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Search of human proteins with 19913406
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19913406 DNA topoisomerase II, alpha isozyme [Homo sapiens]
(1531 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19913406 DNA topoisomerase II, alpha isozyme [Homo sapiens] 3072 0.0
gi|19913408 DNA topoisomerase II, beta isozyme [Homo sapiens] 2112 0.0
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1... 74 1e-12
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 70 2e-11
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 62 3e-09
gi|104526627 triadin [Homo sapiens] 59 4e-08
gi|55741677 SET domain containing 1A [Homo sapiens] 55 4e-07
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens] 55 7e-07
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens] 55 7e-07
gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sap... 53 2e-06
gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sap... 53 2e-06
gi|217330641 IWS1 homolog [Homo sapiens] 53 3e-06
gi|55956788 nucleolin [Homo sapiens] 52 6e-06
gi|7661950 SH2 domain binding protein 1 [Homo sapiens] 50 1e-05
gi|115334679 retinoblastoma-binding protein 1 isoform III [Homo ... 50 1e-05
gi|115334673 retinoblastoma-binding protein 1 isoform II [Homo s... 50 1e-05
gi|115334677 retinoblastoma-binding protein 1 isoform I [Homo sa... 50 1e-05
gi|4557509 cylicin 2 [Homo sapiens] 50 2e-05
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens] 49 3e-05
gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithora... 49 4e-05
gi|122937247 unc-13 homolog A [Homo sapiens] 48 8e-05
gi|150170670 piccolo isoform 2 [Homo sapiens] 47 1e-04
gi|150378539 piccolo isoform 1 [Homo sapiens] 47 1e-04
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 47 2e-04
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 47 2e-04
gi|87299628 biorientation of chromosomes in cell division 1-like... 46 2e-04
gi|156104891 general transcription factor IIF, polypeptide 1, 74... 46 2e-04
gi|125656165 THO complex 2 [Homo sapiens] 46 3e-04
gi|33356174 pinin, desmosome associated protein [Homo sapiens] 46 3e-04
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 46 3e-04
>gi|19913406 DNA topoisomerase II, alpha isozyme [Homo sapiens]
Length = 1531
Score = 3072 bits (7965), Expect = 0.0
Identities = 1531/1531 (100%), Positives = 1531/1531 (100%)
Query: 1 MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQ 60
MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQ
Sbjct: 1 MEVSPLQPVNENMQVNKIKKNEDAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQ 60
Query: 61 MWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWN 120
MWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWN
Sbjct: 61 MWVYDEDVGINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWN 120
Query: 121 NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE 180
NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE
Sbjct: 121 NGKGIPVVEHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVE 180
Query: 181 TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMV 240
TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMV
Sbjct: 181 TASREYKKMFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMV 240
Query: 241 RRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVC 300
RRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVC
Sbjct: 241 RRAYDIAGSTKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVC 300
Query: 301 LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM 360
LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM
Sbjct: 301 LTMSEKGFQQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHM 360
Query: 361 WIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ 420
WIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ
Sbjct: 361 WIFVNALIENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQ 420
Query: 421 VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDK 480
VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDK
Sbjct: 421 VQLNKKCSAVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDK 480
Query: 481 YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT 540
YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT
Sbjct: 481 YGVFPLRGKILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMT 540
Query: 541 DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS 600
DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS
Sbjct: 541 DQDQDGSHIKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKS 600
Query: 601 STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD 660
STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD
Sbjct: 601 STPNHKKWKVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDD 660
Query: 661 RKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD 720
RKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD
Sbjct: 661 RKEWLTNFMEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVD 720
Query: 721 GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN 780
GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN
Sbjct: 721 GLKPGQRKVLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNN 780
Query: 781 LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEW 840
LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEW
Sbjct: 781 LNLLQPIGQFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEW 840
Query: 841 YIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIE 900
YIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIE
Sbjct: 841 YIPIIPMVLINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIE 900
Query: 901 ELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY 960
ELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY
Sbjct: 901 ELAPNQYVISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREY 960
Query: 961 HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR 1020
HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR
Sbjct: 961 HTDTTVKFVVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILR 1020
Query: 1021 DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR 1080
DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR
Sbjct: 1021 DFFELRLKYYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQR 1080
Query: 1081 GYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEK 1140
GYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEK
Sbjct: 1081 GYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEK 1140
Query: 1141 KDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKA 1200
KDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKA
Sbjct: 1141 KDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKA 1200
Query: 1201 KGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQ 1260
KGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQ
Sbjct: 1201 KGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQ 1260
Query: 1261 RLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRA 1320
RLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRA
Sbjct: 1261 RLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRA 1320
Query: 1321 ATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLE 1380
ATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLE
Sbjct: 1321 ATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLE 1380
Query: 1381 ADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKG 1440
ADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKG
Sbjct: 1381 ADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKG 1440
Query: 1441 TKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHM 1500
TKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHM
Sbjct: 1441 TKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHM 1500
Query: 1501 DFDSAVAPRAKSVRAKKPIKYLEESDEDDLF 1531
DFDSAVAPRAKSVRAKKPIKYLEESDEDDLF
Sbjct: 1501 DFDSAVAPRAKSVRAKKPIKYLEESDEDDLF 1531
>gi|19913408 DNA topoisomerase II, beta isozyme [Homo sapiens]
Length = 1621
Score = 2112 bits (5471), Expect = 0.0
Identities = 1092/1599 (68%), Positives = 1259/1599 (78%), Gaps = 96/1599 (6%)
Query: 16 NKIKKNE-------DAKKRLSVERIYQKKTQLEHILLRPDTYIGSVELVTQQMWVYDEDV 68
N KK E D+ K+LSVER+YQKKTQLEHILLRPDTYIGSVE +TQ MWVYDEDV
Sbjct: 25 NAAKKEESETANKNDSSKKLSVERVYQKKTQLEHILLRPDTYIGSVEPLTQFMWVYDEDV 84
Query: 69 GINYREVTFVPGLYKIFDEILVNAADNKQRDPKMSCIRVTIDPENNLISIWNNGKGIPVV 128
G+N REVTFVPGLYKIFDEILVNAADNKQRD M+CI+V+IDPE+N+ISIWNNGKGIPVV
Sbjct: 85 GMNCREVTFVPGLYKIFDEILVNAADNKQRDKNMTCIKVSIDPESNIISIWNNGKGIPVV 144
Query: 129 EHKVEKMYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETASREYKK 188
EHKVEK+YVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETA +EYK
Sbjct: 145 EHKVEKVYVPALIFGQLLTSSNYDDDEKKVTGGRNGYGAKLCNIFSTKFTVETACKEYKH 204
Query: 189 MFKQTWMDNMGRAGEMELKPFNGEDYTCITFQPDLSKFKMQSLDKDIVALMVRRAYDIAG 248
FKQTWM+NM + E ++K F+GEDYTCITFQPDLSKFKM+ LDKDIVALM RRAYD+AG
Sbjct: 205 SFKQTWMNNMMKTSEAKIKHFDGEDYTCITFQPDLSKFKMEKLDKDIVALMTRRAYDLAG 264
Query: 249 STKDVKVFLNGNKLPVKGFRSYVDMYLKDKLDETGNSLKVIHEQVNHRWEVCLTMSEKGF 308
S + VKV NG KLPV GFRSYVD+Y+KDKLDETG +LKVIHE N RW+VCLT+SEKGF
Sbjct: 265 SCRGVKVMFNGKKLPVNGFRSYVDLYVKDKLDETGVALKVIHELANERWDVCLTLSEKGF 324
Query: 309 QQISFVNSIATSKGGRHVDYVADQIVTKLVDVVKKKNKGGVAVKAHQVKNHMWIFVNALI 368
QQISFVNSIAT+KGGRHVDYV DQ+V KL++VVKKKNK GV+VK QVKNH+W+F+N LI
Sbjct: 325 QQISFVNSIATTKGGRHVDYVVDQVVGKLIEVVKKKNKAGVSVKPFQVKNHIWVFINCLI 384
Query: 369 ENPTFDSQTKENMTLQPKSFGSTCQLSEKFIKAAIGCGIVESILNWVKFKAQVQLNKKCS 428
ENPTFDSQTKENMTLQPKSFGS CQLSEKF KAA CGIVESILNWVKFKAQ QLNKKCS
Sbjct: 385 ENPTFDSQTKENMTLQPKSFGSKCQLSEKFFKAASNCGIVESILNWVKFKAQTQLNKKCS 444
Query: 429 AVKHNRIKGIPKLDDANDAGGRNSTECTLILTEGDSAKTLAVSGLGVVGRDKYGVFPLRG 488
+VK+++IKGIPKLDDANDAGG++S ECTLILTEGDSAK+LAVSGLGV+GRD+YGVFPLRG
Sbjct: 445 SVKYSKIKGIPKLDDANDAGGKHSLECTLILTEGDSAKSLAVSGLGVIGRDRYGVFPLRG 504
Query: 489 KILNVREASHKQIMENAEINNIIKIVGLQYKKNYEDEDSLKTLRYGKIMIMTDQDQDGSH 548
KILNVREASHKQIMENAEINNIIKIVGLQYKK+Y+D +SLKTLRYGKIMIMTDQDQDGSH
Sbjct: 505 KILNVREASHKQIMENAEINNIIKIVGLQYKKSYDDAESLKTLRYGKIMIMTDQDQDGSH 564
Query: 549 IKGLLINFIHHNWPSLLRHRFLEEFITPIVKVSKNKQEMAFYSLPEFEEWKSSTPNHKKW 608
IKGLLINFIHHNWPSLL+H FLEEFITPIVK SKNKQE++FYS+PEF+EWK N K W
Sbjct: 565 IKGLLINFIHHNWPSLLKHGFLEEFITPIVKASKNKQELSFYSIPEFDEWKKHIENQKAW 624
Query: 609 KVKYYKGLGTSTSKEAKEYFADMKRHRIQFKYSGPEDDAAISLAFSKKQIDDRKEWLTNF 668
K+KYYKGLGTST+KEAKEYFADM+RHRI F+Y+GPEDDAAI+LAFSKK+IDDRKEWLTNF
Sbjct: 625 KIKYYKGLGTSTAKEAKEYFADMERHRILFRYAGPEDDAAITLAFSKKKIDDRKEWLTNF 684
Query: 669 MEDRRQRKLLGLPEDYLYGQTTTYLTYNDFINKELILFSNSDNERSIPSMVDGLKPGQRK 728
MEDRRQR+L GLPE +LYG T +LTYNDFINKELILFSNSDNERSIPS+VDG KPGQRK
Sbjct: 685 MEDRRQRRLHGLPEQFLYGTATKHLTYNDFINKELILFSNSDNERSIPSLVDGFKPGQRK 744
Query: 729 VLFTCFKRNDKREVKVAQLAGSVAEMSSYHHGEMSLMMTIINLAQNFVGSNNLNLLQPIG 788
VLFTCFKRNDKREVKVAQLAGSVAEMS+YHHGE +LMMTI+NLAQNFVGSNN+NLLQPIG
Sbjct: 745 VLFTCFKRNDKREVKVAQLAGSVAEMSAYHHGEQALMMTIVNLAQNFVGSNNINLLQPIG 804
Query: 789 QFGTRLHGGKDSASPRYIFTMLSSLARLLFPPKDDHTLKFLYDDNQRVEPEWYIPIIPMV 848
QFGTRLHGGKD+ASPRYIFTMLS+LARLLFP DD+ LKFLYDDNQRVEPEWYIPIIPMV
Sbjct: 805 QFGTRLHGGKDAASPRYIFTMLSTLARLLFPAVDDNLLKFLYDDNQRVEPEWYIPIIPMV 864
Query: 849 LINGAEGIGTGWSCKIPNFDVREIVNNIRRLMDGEEPLPMLPSYKNFKGTIEELAPNQYV 908
LINGAEGIGTGW+CK+PN+D REIVNN+RR++DG +P PMLP+YKNFKGTI+EL NQY
Sbjct: 865 LINGAEGIGTGWACKLPNYDAREIVNNVRRMLDGLDPHPMLPNYKNFKGTIQELGQNQYA 924
Query: 909 ISGEVAILNSTTIEISELPVRTWTQTYKEQVLEPMLNGTEKTPPLITDYREYHTDTTVKF 968
+SGE+ +++ T+EI+ELPVRTWTQ YKEQVLEPMLNGT+KTP LI+DY+EYHTDTTVKF
Sbjct: 925 VSGEIFVVDRNTVEITELPVRTWTQVYKEQVLEPMLNGTDKTPALISDYKEYHTDTTVKF 984
Query: 969 VVKMTEEKLAEAERVGLHKVFKLQTSLTCNSMVLFDHVGCLKKYDTVLDILRDFFELRLK 1028
VVKMTEEKLA+AE GLHKVFKLQT+LTCNSMVLFDH+GCLKKY+TV DIL++FF+LRL
Sbjct: 985 VVKMTEEKLAQAEAAGLHKVFKLQTTLTCNSMVLFDHMGCLKKYETVQDILKEFFDLRLS 1044
Query: 1029 YYGLRKEWLLGMLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVK 1088
YYGLRKEWL+GMLGAES KLNNQARFILEKI GKI IEN+ KK+LI++L+QRGY+SDPVK
Sbjct: 1045 YYGLRKEWLVGMLGAESTKLNNQARFILEKIQGKITIENRSKKDLIQMLVQRGYESDPVK 1104
Query: 1089 AWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLR 1148
AWKEAQ+K +E+E + N+ + SDS T SGP FNY+L+M LW LTKEK +EL + R
Sbjct: 1105 AWKEAQEKAAEEDETQ---NQHDDSSSDSGTPSGPDFNYILNMSLWSLTKEKVEELIKQR 1161
Query: 1149 NEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKG-----GKAKGK 1203
+ K +E++ LKRKSPSDLWKEDLA F+EEL+ VE++E++D G+ GK GK K K
Sbjct: 1162 DAKGREVNDLKRKSPSDLWKEDLAAFVEELDKVESQEREDVLAGMSGKAIKGKVGKPKVK 1221
Query: 1204 KTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNE------NTEGSPQEDGVELEG 1257
K Q+ E +PSP G+R+IP IT MKA+A KK KK K + E + G +EG
Sbjct: 1222 KLQLEETMPSPYGRRIIPEIT-AMKADASKKLLKKKKGDLDTAAVKVEFDEEFSGAPVEG 1280
Query: 1258 L------------KQRLEKKQKREPGTKTKKQTTLAFKP-IKKGKKRNPWSDSESDRSSD 1304
K K++K+EPGT+ +K T + KP KK KKRNPWSD ES SD
Sbjct: 1281 AGEEALTPSVPINKGPKPKREKKEPGTRVRKTPTSSGKPSAKKVKKRNPWSDDESKSESD 1340
Query: 1305 --ESNFDVPPRETEPRRAAT-KTKFTMDLDSDEDFSDFDEKTDD---------------- 1345
E+ V PR++ RRAA + K+T D +ED D D+ DD
Sbjct: 1341 LEETEPVVIPRDSLLRRAAAERPKYTFDFSEEED-DDADDDDDDNNDLEELKVKASPITN 1399
Query: 1346 ---EDFVPSDA--------SPPKTKTSPKLSNKELKPQ--------KSVVSDLEADDVKG 1386
++FVPSD SP K+K +P+ S + K Q S E D K
Sbjct: 1400 DGEDEFVPSDGLDKDEYTFSPGKSKATPEKSLHDKKSQDFGNLFSFPSYSQKSEDDSAKF 1459
Query: 1387 SVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPA 1446
S + T+ VP K V AAK +S T K + APK K A
Sbjct: 1460 DSNEEDSASVFSPSFGLKQTDKVPSKTV-----AAKKGKPSSDTVPKPKRAPKQKKVVEA 1514
Query: 1447 LNS------GVSQKPDPAKTKNR--RKRKPSTSD-DSDSNFEKIVSKAVTSKKSKGES-- 1495
+NS G+ +K K K R +KRK S S+ + D N + SK TSKK K S
Sbjct: 1515 VNSDSDSEFGIPKKTTTPKGKGRGAKKRKASGSENEGDYNPGRKTSK-TTSKKPKKTSFD 1573
Query: 1496 -----DDFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDD 1529
D F DF + ++ RA+K +KY ESDE++
Sbjct: 1574 QDSDVDIFPSDFPTEPPSLPRTGRARKEVKYFAESDEEE 1612
Score = 41.2 bits (95), Expect = 0.008
Identities = 65/270 (24%), Positives = 110/270 (40%), Gaps = 41/270 (15%)
Query: 1090 WKEAQQKVPDEEENEESDNEKETEKSDSVTDSG-----PTFNYLLDMPLWYLTKEKKDEL 1144
+ E + D+++++ +D E+ K+ +T+ G P+ D + K K
Sbjct: 1369 FSEEEDDDADDDDDDNNDLEELKVKASPITNDGEDEFVPSDGLDKDEYTFSPGKSKATPE 1428
Query: 1145 CRLRNEKEQELDTL-KRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKAKGK 1203
L ++K Q+ L S S ++D A F ++ E+ V P G K K
Sbjct: 1429 KSLHDKKSQDFGNLFSFPSYSQKSEDDSAKF-------DSNEEDSASVFSPSFGLKQTDK 1481
Query: 1204 KTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELE------- 1256
++ + + +G+ P K + K KK ++ N++ S E G+ +
Sbjct: 1482 VP--SKTVAAKKGK---PSSDTVPKPKRAPKQKKVVEAVNSD-SDSEFGIPKKTTTPKGK 1535
Query: 1257 --GLKQRLEKKQKRE----PGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDV 1310
G K+R + E PG KT K T+ KK KK + D +SD S+F
Sbjct: 1536 GRGAKKRKASGSENEGDYNPGRKTSKTTS------KKPKKTS--FDQDSDVDIFPSDFPT 1587
Query: 1311 -PPRETEPRRAATKTKFTMDLDSDEDFSDF 1339
PP RA + K+ + D +ED DF
Sbjct: 1588 EPPSLPRTGRARKEVKYFAESDEEEDDVDF 1617
>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
[Homo sapiens]
Length = 651
Score = 73.6 bits (179), Expect = 1e-12
Identities = 113/500 (22%), Positives = 189/500 (37%), Gaps = 61/500 (12%)
Query: 1060 DGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDE---EENEESDNEKETEKSD 1116
+ K I+E K K+ Q D P+K+ E +Q + E N ES N K K+
Sbjct: 143 ESKQIVEEKTKR-------QNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNC 195
Query: 1117 SVTD---------SGPTFNYLLDMPLWYLTKEK--KDELCRLRNEKEQELDTLKRKSPSD 1165
S D + F + + P L + K D + + +E +D L SD
Sbjct: 196 SQKDKKDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSD 255
Query: 1166 LWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITI 1225
+ ++ +K + K K KK+ AE S ++ ++
Sbjct: 256 DESINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKV-- 313
Query: 1226 EMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKKQKREPGTKTKKQTTLAFKPI 1285
K +K +KKK ++TE + E G + K +R+ K KK+ K
Sbjct: 314 --KKNVKKDDKKKDVKKDTESTDAESG----------DSKDERKDTKKDKKKLKKDDK-- 359
Query: 1286 KKGKKRNPWS-DSES----DRSSDESNFDVPPRETEPRRAATKTKFTMDLDS-------- 1332
KK K+ P S D+ES D +D N + + ++ A K F+ D +S
Sbjct: 360 KKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQ 419
Query: 1333 -DEDFSDFDEKTDDEDFVPSDASPPKTKTSPK-LSNKELKPQKSVVSDLEADDVKGSVPL 1390
DE D KTD++ V +D + PK S K K +K D + DD K
Sbjct: 420 KDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDA-- 477
Query: 1391 SSSPPATHFPDETEITNPVPKKNVTVKKTAAK-----SQSSTSTTGAKKRAAPKGTKRDP 1445
+ +T + E+ KK+ KK + K ++ T +T A+ + K +
Sbjct: 478 KKNAESTEMESDLELKK--DKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTS 535
Query: 1446 ALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSA 1505
G + + + K K+K SD + +N + ++ + + F+ + A
Sbjct: 536 TKIKGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKA 595
Query: 1506 VAPRAKSVRAKKPIKYLEES 1525
R R K P+ E S
Sbjct: 596 STGRVPPSREKPPLPACEPS 615
Score = 40.8 bits (94), Expect = 0.010
Identities = 72/348 (20%), Positives = 122/348 (35%), Gaps = 53/348 (15%)
Query: 1228 KAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKKQKREPGTKTKKQTTLAFKPI-- 1285
K +K KK K+E G+P + + +G + K+ KTK+Q P+
Sbjct: 107 KTHLKKAEYKKSKDEKG-GTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTPLKS 165
Query: 1286 ----------KKGKKRNPWS-------------DSESDRSSDESNFDVPPRETEPRRAAT 1322
K + NP S D + ++S ++N + + P++
Sbjct: 166 SHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNNPKKDLK 225
Query: 1323 KTKFTMDLDSD--------EDFSDFDEKTDDEDF--------VPSDASPPKTKTSPKLSN 1366
++K + D S+ DF ++DDE + S + K +
Sbjct: 226 RSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYSLKYTKYTK 285
Query: 1367 KELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSS 1426
K+ K SD E++D K + S D+ + V K + + S+
Sbjct: 286 KDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKK--KDVKKDTESTDAESGDSKDE 343
Query: 1427 TSTT-----GAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKI 1481
T KK K TK+ P S A+ +R +K S +DD + +KI
Sbjct: 344 RKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKI 403
Query: 1482 VSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDD 1529
S S+ E + D + KK +K EES + D
Sbjct: 404 ----TFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDAD 447
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 70.1 bits (170), Expect = 2e-11
Identities = 103/465 (22%), Positives = 174/465 (37%), Gaps = 54/465 (11%)
Query: 1102 ENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRK 1161
+N+ S+ + K+ T + LLD+ ++L K E +L+ K+
Sbjct: 24 DNQLSEVANKFAKATGATQQDANASSLLDIYSFWLKSAKVPER-KLQANGPVAKKAKKKA 82
Query: 1162 SPSDLWKEDLATFIEELEAVEAKEKQ--DEQVGLPGKGGKAKGKKTQMAEVLPSP---RG 1216
S SD ED + EE++ AK+ ++VGLP AK ++ +E
Sbjct: 83 SSSD--SEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEED 140
Query: 1217 QRVIP-RITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKKQKREPGTKTK 1275
Q+ P + ++ +A+A K KK K+ +++ + + K ++ + TK
Sbjct: 141 QKKQPVQKGVKPQAKAAKAPPKKAKSSDSDSDSSSEDEPPKNQKPKITPVTVKAQ-TKAP 199
Query: 1276 KQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFD---VPPRETEPRRAATK-------TK 1325
+ A I GK + S S S SSD+S + P++T P++ T
Sbjct: 200 PKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATT 259
Query: 1326 FTMDLDSDEDFSDFDEKTDDEDFV----------PSDASPPKTKTSPKLSNKELKPQKSV 1375
T S ED S +E+ + P A PPK + K ++ Q+ V
Sbjct: 260 PTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEKQQPV 319
Query: 1376 VSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKR 1435
S ++ D S P T T P P K + + S+ A +
Sbjct: 320 ESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDDEAPSK 379
Query: 1436 AA---------PKGTKRDPALNSGVSQKPDPA---KTKNRRKRKPSTSDDSDSNFEKIVS 1483
A P T + PA+ + K K R+ S+ ++S S+ E+
Sbjct: 380 PAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTK 439
Query: 1484 KAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDED 1528
K V + K K A A A S+ AK+ + +S D
Sbjct: 440 KMVATTKPK------------ATAKAALSLPAKQAPQGSRDSSSD 472
Score = 47.0 bits (110), Expect = 1e-04
Identities = 77/343 (22%), Positives = 123/343 (35%), Gaps = 47/343 (13%)
Query: 1221 PRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKKQKREPGTKTKKQT-- 1278
P+ T+ K K K + S ED E +Q+ K K P + +
Sbjct: 239 PKKTVPKKQVVAKAPVKAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAP 298
Query: 1279 ----TLAFKPIKKG-KKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMD---- 1329
+L +P KK +K+ P SE SSDES+ + P +A T
Sbjct: 299 PPKKSLGTQPPKKAVEKQQPVESSED--SSDESDSSSEEEKKPPTKAVVSKATTKPPPAK 356
Query: 1330 --LDSDEDFSDFDEKTDDEDFVPSDAS---------PPKTKTSPKLS-----------NK 1367
+S D SD D DDE PS + P T SP + +
Sbjct: 357 KAAESSSDSSDSDSSEDDE--APSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQ 414
Query: 1368 ELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDET-EITNPVPKKNVTVKKTAAKSQS- 1425
+L +K+ S E + + AT P T + +P K + S S
Sbjct: 415 KLLTRKADSSSSEEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSD 474
Query: 1426 STSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKA 1485
S+S+ +++ + K+ P +G + PA K + ++S DS+ E+
Sbjct: 475 SSSSEEEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEE----- 529
Query: 1486 VTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDED 1528
+K KG+ A A + + K K EE +E+
Sbjct: 530 --EEKLKGKGSP-RPQAPKANGTSALTAQNGKAAKNSEEEEEE 569
Score = 33.9 bits (76), Expect = 1.2
Identities = 42/195 (21%), Positives = 74/195 (37%), Gaps = 5/195 (2%)
Query: 1101 EENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKR 1160
EE S E++T+K + T T L +P + +D + +E +
Sbjct: 427 EEESSSSEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSEEEEEKTS 486
Query: 1161 KSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVI 1220
KS + +A + AK+ + E ++ ++ ++ + SPR Q
Sbjct: 487 KSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKL-KGKGSPRPQAPK 545
Query: 1221 PRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKKQKREPGT----KTKK 1276
T + A+ K K + E + + LK+R + + +E T K K
Sbjct: 546 ANGTSALTAQNGKAAKNSEEEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQAKKIKL 605
Query: 1277 QTTLAFKPIKKGKKR 1291
QT F KKG+KR
Sbjct: 606 QTPNTFPKRKKGEKR 620
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 62.4 bits (150), Expect = 3e-09
Identities = 98/488 (20%), Positives = 175/488 (35%), Gaps = 38/488 (7%)
Query: 1047 KLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENE-E 1105
K+ + + I K + KI + K +KE + V Q + +E +++ +EE E E
Sbjct: 428 KIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEE 487
Query: 1106 SDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSD 1165
E+E E + T S P P K+E K E + + KSP++
Sbjct: 488 GGEEEEAEGGEEETKSPPAEE--AASPEKEAKSPVKEEAKSPAEAKSPEKE--EAKSPAE 543
Query: 1166 LWKEDLATFIEELEA---VEAKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPR 1222
+ + A + EA EAK + E+ P + + K+ E SP + +
Sbjct: 544 VKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEK 603
Query: 1223 ITIEMKAEA------------EKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKKQKREP 1270
+K EA E K+ ++K+ SP ++ + + EK++ + P
Sbjct: 604 AKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSP 663
Query: 1271 GTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDL 1330
K K K +K K +S +++ V P +A + K
Sbjct: 664 -EKAKSPVKAEAKSPEKAKS----PVKAEAKSPEKAKSPVKEEAKSPEKAKSPVK----- 713
Query: 1331 DSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPL 1390
+ + +E P A P K K K P+K+ D+++ + K
Sbjct: 714 EEAKSPEKAKSPVKEEAKTPEKAKSP-VKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKE 772
Query: 1391 SSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSG 1450
+ PA FP++ + K+ K+ K + K+ K ++
Sbjct: 773 EARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQE 832
Query: 1451 VSQKPDPAKTKNRR-KRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAVAPR 1509
V K P K + + P T + DS E+ K K + + + + P+
Sbjct: 833 VKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKE------PAVEKPK 886
Query: 1510 AKSVRAKK 1517
V AKK
Sbjct: 887 ESKVEAKK 894
Score = 60.8 bits (146), Expect = 9e-09
Identities = 86/426 (20%), Positives = 162/426 (38%), Gaps = 57/426 (13%)
Query: 1085 DPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDEL 1144
+ K+ + + K P++ ++ E + K EK+ S + P+ K +
Sbjct: 636 EKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAK 695
Query: 1145 CRLRNE-----------KEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGL 1193
++ E KE+ K KSP KE+ T + V+ + K E+
Sbjct: 696 SPVKEEAKSPEKAKSPVKEEAKSPEKAKSPV---KEEAKTPEKAKSPVKEEAKSPEKAKS 752
Query: 1194 PGKGG----KAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQ 1249
P K K+ KT E SP + + +K E + K K + +P+
Sbjct: 753 PEKAKTLDVKSPEAKTPAKEEARSP-ADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPE 811
Query: 1250 EDGVELEGLKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFD 1309
++ + E +K +++++K + K K+ P KK ++ + +++ D +
Sbjct: 812 KEIPKKEEVKSPVKEEEKPQE-VKVKE-------PPKKAEEEKAPATPKTEEKKDSKKEE 863
Query: 1310 VPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKEL 1369
P +E + K + ++ + E+ +D+ VP+ K K ++
Sbjct: 864 APKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVK---EDA 920
Query: 1370 KP-QKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTS 1428
KP +K+ V+ E DD K P + P++ + KK KT AK++
Sbjct: 921 KPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDK 980
Query: 1429 TTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTS 1488
T +S++P K K + K S++D DS K KA
Sbjct: 981 T---------------------LSKEPS--KPKAEKAEKSSSTDQKDS---KPPEKATED 1014
Query: 1489 KKSKGE 1494
K +KG+
Sbjct: 1015 KAAKGK 1020
Score = 55.1 bits (131), Expect = 5e-07
Identities = 74/319 (23%), Positives = 132/319 (41%), Gaps = 40/319 (12%)
Query: 1214 PRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKKQKREPGTK 1273
P G IP ++ +K ++E+K K K+E +E E + ++ E+++K +
Sbjct: 423 PEGLPKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEK-----E 477
Query: 1274 TKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSD 1333
K++ +GK+ + E++ +E+ PP E AA+ K +
Sbjct: 478 AKEE---------EGKEEEGGEEEEAEGGEEETK--SPPAE----EAASPEKEAKSPVKE 522
Query: 1334 EDFSDFDEKTDDEDFVPSDA---SPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPL 1390
E S + K+ +++ S A SP K K+ K K KS E ++ K +
Sbjct: 523 EAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSP----EKEEAKSPAEV 578
Query: 1391 SSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSG 1450
SP P + E +P K+ K+ K + AK A K ++ A +
Sbjct: 579 -KSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEE-------AKSPAEAKSPVKEEAKSPA 630
Query: 1451 VSQKPDPAKTKNRRKRK-PSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAVAPR 1509
+ P+ AK+ + + K P + + K KA + K++ +S + S V
Sbjct: 631 EVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPE---KAKSPVKAE 687
Query: 1510 AKS-VRAKKPIKYLEESDE 1527
AKS +AK P+K +S E
Sbjct: 688 AKSPEKAKSPVKEEAKSPE 706
Score = 52.0 bits (123), Expect = 4e-06
Identities = 104/509 (20%), Positives = 184/509 (36%), Gaps = 55/509 (10%)
Query: 1069 PKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYL 1128
P+KE + + K+ ++ + K P E ++ E E++ S ++
Sbjct: 512 PEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEE 571
Query: 1129 LDMPLWYLTKEKKDELCRLRNEKEQELDTL-KRKSPSDLWKEDLATFIEELEAVEAKEKQ 1187
P + EK + + E + K KSP KE+ + E V+ + K
Sbjct: 572 AKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPV---KEEAKSPAEAKSPVKEEAKS 628
Query: 1188 DEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKN------ 1241
+V P K ++ + E SP + + +AE K+ +K K+
Sbjct: 629 PAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEA 688
Query: 1242 ---ENTEGSPQEDGVELEGLKQRLEKKQK-----REPGTKTKKQTTLAFKPIKKGKK--- 1290
E + +E+ E K ++++ K + P + K A P+K+ K
Sbjct: 689 KSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPE 748
Query: 1291 --RNPWSDSESDRSSDESNFDVP-----PRETEPRRAAT----------KTKFTMDLDSD 1333
++P D S E+ P + P +A + K K + D+
Sbjct: 749 KAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAK 808
Query: 1334 EDFSDFDEKTDDEDFVPSDASPP--KTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLS 1391
+ +K + + V + P K K PK + +E P + + D K P
Sbjct: 809 APEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEE-KKDSKKEEAPKK 867
Query: 1392 SSP-PATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRD--PALN 1448
+P P E + P K V KK A+ + T K+ A K D P
Sbjct: 868 EAPKPKVEEKKEPAVEKPKESK-VEAKKEEAEDKKKVPTP-EKEAPAKVEVKEDAKPKEK 925
Query: 1449 SGVSQK-PDPAKTK------NRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHMD 1501
+ V++K PD AK K +++ P D + +K K T K+K + +
Sbjct: 926 TEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKE 985
Query: 1502 FDSAVAPRAK--SVRAKKPIKYLEESDED 1528
A +A+ S +K K E++ ED
Sbjct: 986 PSKPKAEKAEKSSSTDQKDSKPPEKATED 1014
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 58.9 bits (141), Expect = 4e-08
Identities = 109/503 (21%), Positives = 199/503 (39%), Gaps = 95/503 (18%)
Query: 1066 ENKPKKELIKVLIQRGYDSDPVK---AWKEAQQKVPDEEENEESDNEKETEKSDSVTDSG 1122
E K KKE+ +G + VK A + QK P + + +E D EK D
Sbjct: 215 EEKTKKEV------KGGKQEKVKQTAAKVKEVQKTPSKPKEKE-DKEKAAVSKHEQKDQY 267
Query: 1123 PTFNYLLDM----------------PLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDL 1166
Y++D+ PL + EKE E ++K S+
Sbjct: 268 AFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSET 327
Query: 1167 WK---EDLATFIEELEAVEAKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRI 1223
K ED+ E+ A++ ++K+ PGK + K ++A + + +
Sbjct: 328 KKKEKEDIKKKSEKETAIDVEKKE------PGKASETKQGTVKIAAQAAAKKDE------ 375
Query: 1224 TIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKKQKR-EPGTKTKKQTTLAF 1282
K E KK KK + E +G QE KK+K EP KK+ ++
Sbjct: 376 ----KKEDSKKTKKPAEVEQPKGKKQE-------------KKEKHVEPAKSPKKEHSV-- 416
Query: 1283 KPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFS----- 1337
P K K ++++R+ +E V ++ P + KT T++ + ++ S
Sbjct: 417 -PSDKQVK------AKTERAKEEIGA-VSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSS 468
Query: 1338 ---DFDEKTDDEDFVPSDASP--PKTKTSPKLSN--KELKPQKSVVSDLEADDVKGSVPL 1390
D + E+ VP+ P+TK K+S KE+KP+ + + + + +
Sbjct: 469 ILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKK 528
Query: 1391 SSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSG 1450
+ P + + P+K V+ K K +K A PK TK+
Sbjct: 529 EAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTAKPKPTKK----AEH 584
Query: 1451 VSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAVAPRA 1510
++P KT + TS+ ++S +K ++ K+SK ++D H+ + V+ R
Sbjct: 585 REREPPSIKTDKPKPTPKGTSEVTESGKKK---TEISEKESKEKADMKHLR-EEKVSTRK 640
Query: 1511 KSV------RAKKPIKYLEESDE 1527
+S+ +A+KP + ++ ++
Sbjct: 641 ESLQLHNVTKAEKPARVSKDVED 663
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 55.5 bits (132), Expect = 4e-07
Identities = 77/350 (22%), Positives = 132/350 (37%), Gaps = 36/350 (10%)
Query: 1134 WYLTKEKKD---ELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQ 1190
W+ +KE+K + + KE++ + K K P L D A +
Sbjct: 826 WWESKEEKAKPFQNAAKQQAKEEDKEKTKLKEPGLLSLVDWA----------------KS 869
Query: 1191 VGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQE 1250
G G A G + A LPS + +R P E A EK+ + E E P++
Sbjct: 870 GGTTGIEAFAFGSGLRGALRLPSFKVKRKEPSEISE--ASEEKRPRPSTPAEEDEDDPEQ 927
Query: 1251 DGVELEGLKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDV 1310
+ E + + ++ E KT+ + +F +G++ + S SE D DE + +
Sbjct: 928 EKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEED 987
Query: 1311 PPRETEPRRAATKTKFTMDLDSDED-------FSDFDEKTD--DEDFVPSDASPPKTKTS 1361
RE +T+ + D + D ++D D + D + S +S + +S
Sbjct: 988 EDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSS 1047
Query: 1362 PKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPP-ATHFPDETEITNPVPKKNVTVKKTA 1420
S+ +S D E ++ ++P +S PP P + PVP++ T
Sbjct: 1048 SSSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTP 1107
Query: 1421 AKSQ--SSTSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKP 1468
Q S G + + P R P +G P PA + R P
Sbjct: 1108 LPEQEASPARPAGPTEESPPSAPLRPPEPPAG---PPAPAPRPDERPSSP 1154
>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
Length = 2454
Score = 54.7 bits (130), Expect = 7e-07
Identities = 97/452 (21%), Positives = 175/452 (38%), Gaps = 65/452 (14%)
Query: 1084 SDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDE 1143
SD + Q K EE+ + SD +K+ K + +S L +++E
Sbjct: 936 SDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLP---------EREE 986
Query: 1144 LCRLRNEKEQ--------ELDTLKRKSPSDLWKEDLATFIEE-------LEAVEAKEKQD 1188
+C +Q E + K + + K++L+ + E+ ++ E K+ ++
Sbjct: 987 ICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKN 1046
Query: 1189 EQVGLPGKGGKAKGKKTQMAEVLPSPRGQRV-------------IPRITI-EMKAEAEKK 1234
G K K GK ++ + S ++ + RI + E + + K+
Sbjct: 1047 GAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKR 1106
Query: 1235 NKKKIKNENTEGSPQEDGVELEGLKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPW 1294
N K+I++ ++ +E + + KQR K+K K KK+ +L + K K+ +
Sbjct: 1107 NTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVI-VKEKKRNSL--RTSTKRKQADIT 1163
Query: 1295 SDSESDRSSDESNF---------DVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDD 1345
S S SD D+ N + P TE ++ T F DE S T D
Sbjct: 1164 SSSSSDIEDDDQNSIGEGSSDEQKIKP-VTENLVLSSHTGFCQS-SGDEALSKSVPVTVD 1221
Query: 1346 EDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEI 1405
+D D + P+ + + K+ +E+K S D +DD + P + E
Sbjct: 1222 DD---DDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEA 1278
Query: 1406 TNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAK-TKNRR 1464
N V ++ + S+ S + K T D KP K K R
Sbjct: 1279 KNQVNSES------DSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRN 1332
Query: 1465 KRKPSTSDDSDSNFEKIVSKAVTSKKSKGESD 1496
+RK S+ D DS+F++ V+ + S+ E +
Sbjct: 1333 RRKVSSEDSEDSDFQE---SGVSEEVSESEDE 1361
Score = 49.7 bits (117), Expect = 2e-05
Identities = 55/264 (20%), Positives = 110/264 (41%), Gaps = 25/264 (9%)
Query: 1083 DSDPVKAWKEAQQKVPDEEENEESDNEKETEK-SDSVTDSGPTFNYLLDMPLWYLTKEKK 1141
D +P + K ++ + +EE+ N+ +E SDS P + + L ++ +
Sbjct: 1255 DDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGES 1314
Query: 1142 DELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKAK 1201
E + + ++ +E+ R+ S ED + F E + E E +DEQ +
Sbjct: 1315 GEEKKTKPKEHKEVKGRNRRKVSSEDSED-SDFQESGVSEEVSESEDEQ-----RPRTRS 1368
Query: 1202 GKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQR 1261
KK ++ E S + ++ RI ++ + +E K+ + + E E +E+ E E ++
Sbjct: 1369 AKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEE--EEE 1426
Query: 1262 LEKKQKREPGTKTKK------------QTTLAFKPIKKGKKRNPWSDSESDRSSDESNFD 1309
E + PG KK +T A K ++ +KR +E +R ++
Sbjct: 1427 DENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKR----IAEREREREKLREV 1482
Query: 1310 VPPRETEPRRAATKTKFTMDLDSD 1333
+ + P + TK +D D +
Sbjct: 1483 IEIEDASPTKCPITTKLVLDEDEE 1506
Score = 41.6 bits (96), Expect = 0.006
Identities = 95/452 (21%), Positives = 169/452 (37%), Gaps = 66/452 (14%)
Query: 1095 QKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQE 1154
Q VP EE+ E +KSD +E + E + + +
Sbjct: 438 QNVPTEEQRTNKSTGGEHKKSDR-------------------KEEPQYEPANTSEDLDMD 478
Query: 1155 LDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQV-GLPGKGGKAKGKKTQMAEVLPS 1213
+ ++ P D++ E+L T A+E + D Q G G + + ++
Sbjct: 479 IVSVPSSVPEDIF-ENLET------AMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKD 531
Query: 1214 PRG---QRVIPRITIEM--KAEAEKKNKKKIKNENTEGSPQE-DGVELEGLKQRLEKKQK 1267
RG + ++T E+ K + IK + + PQ+ DG + GL +LEK
Sbjct: 532 NRGGIKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGL 591
Query: 1268 REPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPR-ETEPRRAATKTKF 1326
+ + + ++E +ES+ PR +T P R T+T
Sbjct: 592 GQENSDNEHLV-----------------ENEVSLLLEESDLRRSPRVKTTPLRRPTETN- 633
Query: 1327 TMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSN----KELKPQKSVVSDLEAD 1382
+ +SDE+ ++ K + VP + + + N K K ++S D +D
Sbjct: 634 PVTSNSDEECNE-TVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSD 692
Query: 1383 DVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKR-AAPKGT 1441
+ L +H N + + T+ K+Q+ G +KR ++ G+
Sbjct: 693 SDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDL--KTQAGKDDKGKRKRKSSTSGS 750
Query: 1442 KRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFE-KIVSK---AVTSKKSKGESDD 1497
D G S K K R+ + S++ DS+ E K +SK A T+KK + D
Sbjct: 751 DFDT--KKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKD 808
Query: 1498 FHMDFDSAVAPRAKSVRAKKPIKYLEESDEDD 1529
F D + + + K +K +E DD
Sbjct: 809 FDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDD 840
Score = 38.1 bits (87), Expect = 0.066
Identities = 41/194 (21%), Positives = 83/194 (42%), Gaps = 39/194 (20%)
Query: 1230 EAEKKNKKKIKNENTEGSP-QEDGVELEGLKQRLEKKQKREPGTKTKKQTTLAF--KPIK 1286
E + +N++K+ +E++E S QE GV ++ E + ++ P T++ K+ L + K
Sbjct: 1327 EVKGRNRRKVSSEDSEDSDFQESGVS----EEVSESEDEQRPRTRSAKKAELEENQRSYK 1382
Query: 1287 KGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDE 1346
+ KKR E S ++SN + E E +E+ + +E+ ++E
Sbjct: 1383 QKKKRRRIKVQEDSSSENKSNSEEEEEEKE----------------EEEEEEEEEEEEEE 1426
Query: 1347 DFVPSDASPPK---------------TKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLS 1391
D SP K T+T L +E + ++ + E + ++ + +
Sbjct: 1427 DENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIE 1486
Query: 1392 SSPPATHFPDETEI 1405
+ P T P T++
Sbjct: 1487 DASP-TKCPITTKL 1499
Score = 37.4 bits (85), Expect = 0.11
Identities = 69/342 (20%), Positives = 127/342 (37%), Gaps = 36/342 (10%)
Query: 1040 MLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPD 1099
+LG S K + + EK K N K L ++ ++ + + KE Q
Sbjct: 1058 LLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSS 1117
Query: 1100 EEENEES-DNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTL 1158
+ E S DN+K+ +++ S + + KEKK R +++Q +
Sbjct: 1118 SDAEESSEDNKKKKQRTSSKKKA-------------VIVKEKKRNSLRTSTKRKQA--DI 1162
Query: 1159 KRKSPSDLWKEDLATFIE------ELEAVEAKEKQDEQVGLPGKGGKAKGKKTQMAEVLP 1212
S SD+ +D + E +++ V G G K+ V
Sbjct: 1163 TSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDD 1222
Query: 1213 SPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKKQKREPGT 1272
RI +M E K N ++ +++ P+E K+R K+ + PG
Sbjct: 1223 DDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEG-------KKRTGKQNEENPGD 1275
Query: 1273 KTKK-----QTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFT 1327
+ K ++ + KK + R+ + S ES + + E + + +
Sbjct: 1276 EEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRK 1335
Query: 1328 MDLDSDEDFSDFDEKTDDEDFVPS-DASPPKTKTSPKLSNKE 1368
+ + ED SDF E E+ S D P+T+++ K +E
Sbjct: 1336 VSSEDSED-SDFQESGVSEEVSESEDEQRPRTRSAKKAELEE 1376
Score = 34.3 bits (77), Expect = 0.95
Identities = 29/119 (24%), Positives = 54/119 (45%), Gaps = 10/119 (8%)
Query: 1068 KPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNY 1127
K KK+ ++ +Q S+ +E +++ +EEE EE + E+E +++D G
Sbjct: 1382 KQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRK- 1440
Query: 1128 LLDMPLWYLTKEKKDELCR--LRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAK 1184
+ K KD+ R +N ++E + KR + + +E L IE +A K
Sbjct: 1441 -------KIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTK 1492
>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
Length = 2492
Score = 54.7 bits (130), Expect = 7e-07
Identities = 97/452 (21%), Positives = 175/452 (38%), Gaps = 65/452 (14%)
Query: 1084 SDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDE 1143
SD + Q K EE+ + SD +K+ K + +S L +++E
Sbjct: 974 SDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLP---------EREE 1024
Query: 1144 LCRLRNEKEQ--------ELDTLKRKSPSDLWKEDLATFIEE-------LEAVEAKEKQD 1188
+C +Q E + K + + K++L+ + E+ ++ E K+ ++
Sbjct: 1025 ICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDSSEDKKSKN 1084
Query: 1189 EQVGLPGKGGKAKGKKTQMAEVLPSPRGQRV-------------IPRITI-EMKAEAEKK 1234
G K K GK ++ + S ++ + RI + E + + K+
Sbjct: 1085 GAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKR 1144
Query: 1235 NKKKIKNENTEGSPQEDGVELEGLKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPW 1294
N K+I++ ++ +E + + KQR K+K K KK+ +L + K K+ +
Sbjct: 1145 NTKEIQSGSSSSDAEESSEDNKKKKQRTSSKKKAVI-VKEKKRNSL--RTSTKRKQADIT 1201
Query: 1295 SDSESDRSSDESNF---------DVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDD 1345
S S SD D+ N + P TE ++ T F DE S T D
Sbjct: 1202 SSSSSDIEDDDQNSIGEGSSDEQKIKP-VTENLVLSSHTGFCQS-SGDEALSKSVPVTVD 1259
Query: 1346 EDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEI 1405
+D D + P+ + + K+ +E+K S D +DD + P + E
Sbjct: 1260 DD---DDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEA 1316
Query: 1406 TNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAK-TKNRR 1464
N V ++ + S+ S + K T D KP K K R
Sbjct: 1317 KNQVNSES------DSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRN 1370
Query: 1465 KRKPSTSDDSDSNFEKIVSKAVTSKKSKGESD 1496
+RK S+ D DS+F++ V+ + S+ E +
Sbjct: 1371 RRKVSSEDSEDSDFQE---SGVSEEVSESEDE 1399
Score = 49.7 bits (117), Expect = 2e-05
Identities = 55/264 (20%), Positives = 110/264 (41%), Gaps = 25/264 (9%)
Query: 1083 DSDPVKAWKEAQQKVPDEEENEESDNEKETEK-SDSVTDSGPTFNYLLDMPLWYLTKEKK 1141
D +P + K ++ + +EE+ N+ +E SDS P + + L ++ +
Sbjct: 1293 DDEPEEGKKRTGKQNEENPGDEEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGES 1352
Query: 1142 DELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKAK 1201
E + + ++ +E+ R+ S ED + F E + E E +DEQ +
Sbjct: 1353 GEEKKTKPKEHKEVKGRNRRKVSSEDSED-SDFQESGVSEEVSESEDEQ-----RPRTRS 1406
Query: 1202 GKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQR 1261
KK ++ E S + ++ RI ++ + +E K+ + + E E +E+ E E ++
Sbjct: 1407 AKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEE--EEE 1464
Query: 1262 LEKKQKREPGTKTKK------------QTTLAFKPIKKGKKRNPWSDSESDRSSDESNFD 1309
E + PG KK +T A K ++ +KR +E +R ++
Sbjct: 1465 DENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKR----IAEREREREKLREV 1520
Query: 1310 VPPRETEPRRAATKTKFTMDLDSD 1333
+ + P + TK +D D +
Sbjct: 1521 IEIEDASPTKCPITTKLVLDEDEE 1544
Score = 41.6 bits (96), Expect = 0.006
Identities = 95/452 (21%), Positives = 169/452 (37%), Gaps = 66/452 (14%)
Query: 1095 QKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQE 1154
Q VP EE+ E +KSD +E + E + + +
Sbjct: 476 QNVPTEEQRTNKSTGGEHKKSDR-------------------KEEPQYEPANTSEDLDMD 516
Query: 1155 LDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQV-GLPGKGGKAKGKKTQMAEVLPS 1213
+ ++ P D++ E+L T A+E + D Q G G + + ++
Sbjct: 517 IVSVPSSVPEDIF-ENLET------AMEVQSSVDHQGDGSSGTEQEVESSSVKLNISSKD 569
Query: 1214 PRG---QRVIPRITIEM--KAEAEKKNKKKIKNENTEGSPQE-DGVELEGLKQRLEKKQK 1267
RG + ++T E+ K + IK + + PQ+ DG + GL +LEK
Sbjct: 570 NRGGIKSKTTAKVTKELYVKLTPVSLSNSPIKGADCQEVPQDKDGYKSCGLNPKLEKCGL 629
Query: 1268 REPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPR-ETEPRRAATKTKF 1326
+ + + ++E +ES+ PR +T P R T+T
Sbjct: 630 GQENSDNEHLV-----------------ENEVSLLLEESDLRRSPRVKTTPLRRPTETN- 671
Query: 1327 TMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSN----KELKPQKSVVSDLEAD 1382
+ +SDE+ ++ K + VP + + + N K K ++S D +D
Sbjct: 672 PVTSNSDEECNE-TVKEKQKLSVPVRKKDKRNSSDSAIDNPKPNKLPKSKQSETVDQNSD 730
Query: 1383 DVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKR-AAPKGT 1441
+ L +H N + + T+ K+Q+ G +KR ++ G+
Sbjct: 731 SDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDL--KTQAGKDDKGKRKRKSSTSGS 788
Query: 1442 KRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFE-KIVSK---AVTSKKSKGESDD 1497
D G S K K R+ + S++ DS+ E K +SK A T+KK + D
Sbjct: 789 DFDT--KKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKKRIPNTKD 846
Query: 1498 FHMDFDSAVAPRAKSVRAKKPIKYLEESDEDD 1529
F D + + + K +K +E DD
Sbjct: 847 FDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDD 878
Score = 38.1 bits (87), Expect = 0.066
Identities = 41/194 (21%), Positives = 83/194 (42%), Gaps = 39/194 (20%)
Query: 1230 EAEKKNKKKIKNENTEGSP-QEDGVELEGLKQRLEKKQKREPGTKTKKQTTLAF--KPIK 1286
E + +N++K+ +E++E S QE GV ++ E + ++ P T++ K+ L + K
Sbjct: 1365 EVKGRNRRKVSSEDSEDSDFQESGVS----EEVSESEDEQRPRTRSAKKAELEENQRSYK 1420
Query: 1287 KGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDE 1346
+ KKR E S ++SN + E E +E+ + +E+ ++E
Sbjct: 1421 QKKKRRRIKVQEDSSSENKSNSEEEEEEKE----------------EEEEEEEEEEEEEE 1464
Query: 1347 DFVPSDASPPK---------------TKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLS 1391
D SP K T+T L +E + ++ + E + ++ + +
Sbjct: 1465 DENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIE 1524
Query: 1392 SSPPATHFPDETEI 1405
+ P T P T++
Sbjct: 1525 DASP-TKCPITTKL 1537
Score = 37.4 bits (85), Expect = 0.11
Identities = 69/342 (20%), Positives = 127/342 (37%), Gaps = 36/342 (10%)
Query: 1040 MLGAESAKLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPD 1099
+LG S K + + EK K N K L ++ ++ + + KE Q
Sbjct: 1096 LLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSS 1155
Query: 1100 EEENEES-DNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTL 1158
+ E S DN+K+ +++ S + + KEKK R +++Q +
Sbjct: 1156 SDAEESSEDNKKKKQRTSSKKKA-------------VIVKEKKRNSLRTSTKRKQA--DI 1200
Query: 1159 KRKSPSDLWKEDLATFIE------ELEAVEAKEKQDEQVGLPGKGGKAKGKKTQMAEVLP 1212
S SD+ +D + E +++ V G G K+ V
Sbjct: 1201 TSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDD 1260
Query: 1213 SPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKKQKREPGT 1272
RI +M E K N ++ +++ P+E K+R K+ + PG
Sbjct: 1261 DDDDNDPENRIAKKMLLEEIKANLSSDEDGSSDDEPEEG-------KKRTGKQNEENPGD 1313
Query: 1273 KTKK-----QTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFT 1327
+ K ++ + KK + R+ + S ES + + E + + +
Sbjct: 1314 EEAKNQVNSESDSDSEESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRK 1373
Query: 1328 MDLDSDEDFSDFDEKTDDEDFVPS-DASPPKTKTSPKLSNKE 1368
+ + ED SDF E E+ S D P+T+++ K +E
Sbjct: 1374 VSSEDSED-SDFQESGVSEEVSESEDEQRPRTRSAKKAELEE 1414
Score = 34.3 bits (77), Expect = 0.95
Identities = 29/119 (24%), Positives = 54/119 (45%), Gaps = 10/119 (8%)
Query: 1068 KPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNY 1127
K KK+ ++ +Q S+ +E +++ +EEE EE + E+E +++D G
Sbjct: 1420 KQKKKRRRIKVQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRK- 1478
Query: 1128 LLDMPLWYLTKEKKDELCR--LRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAK 1184
+ K KD+ R +N ++E + KR + + +E L IE +A K
Sbjct: 1479 -------KIRKILKDDKLRTETQNALKEEEERRKRIAEREREREKLREVIEIEDASPTK 1530
>gi|33620716 retinoblastoma-binding protein 6 isoform 2 [Homo sapiens]
Length = 1758
Score = 53.1 bits (126), Expect = 2e-06
Identities = 82/382 (21%), Positives = 148/382 (38%), Gaps = 76/382 (19%)
Query: 1182 EAKEKQDEQVGLPGKGGK-------AKGKKTQ---MAEVLPSPRGQR------------- 1218
++KEK+ E GKG K KG++++ E+L + R R
Sbjct: 881 KSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSL 940
Query: 1219 -VIP----------------RITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQR 1261
V+P IT + +E +K+ + K K + + + DG + K+
Sbjct: 941 FVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAV-SKKEN 999
Query: 1262 LEKKQK--REPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDV--PPR---- 1313
+ K K +E ++++ + PIKK K+ P +D+ SS + + + PR
Sbjct: 1000 IVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHS 1059
Query: 1314 -------ETEP-RRAATKTKFTMDLDSDE-DFSDFDEKTDDEDFVPSD--ASPPKTKTSP 1362
ET+P + K ++ D+ S++ + K +E P D K KT
Sbjct: 1060 KSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEE 1119
Query: 1363 KLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPAT----HFPDETEITNPVPKKNVTVKK 1418
K +K+ + +S LE ++ P P T P++ +I+ P K + + +
Sbjct: 1120 KGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNR 1179
Query: 1419 TAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNF 1478
K ST K + K S K K K + +RK + ++ S S
Sbjct: 1180 ETGKKIGSTENISNTKEPSEK--------LESTSSKVKQEKVKGKVRRKVTGTEGSSSTL 1231
Query: 1479 EKIVSKAVTS----KKSKGESD 1496
S + T +KS+ ++D
Sbjct: 1232 VDYTSTSSTGGSPVRKSEEKTD 1253
Score = 47.4 bits (111), Expect = 1e-04
Identities = 77/308 (25%), Positives = 111/308 (36%), Gaps = 46/308 (14%)
Query: 1228 KAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKKQKREP-GTKTKKQTTLAFKPIK 1286
K KK++K+ K E +EG + +E ++ REP G + K +L P +
Sbjct: 895 KGNKHKKHRKRRKGEESEGFLNPELLETS--------RKSREPTGVEENKTDSLFVLPSR 946
Query: 1287 KGKK--RNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDF----- 1339
R+ D+ES S D R+ +P+ KTK D + +
Sbjct: 947 DDATPVRDEPMDAESITFKSVSEKDKRERD-KPKAKGDKTKRKNDGSAVSKKENIVKPAK 1005
Query: 1340 --DEKTDDEDFVPSDASPPKTKT---SPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSP 1394
EK D E + PP K +PK N KS S + + + G+ P
Sbjct: 1006 GPQEKVDGERERSPRSEPPIKKAKEETPKTDNT-----KSSSSSQKDEKITGT------P 1054
Query: 1395 PATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQK 1454
H E P K VKK +K S T +++A K P N G +K
Sbjct: 1055 RKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRK 1114
Query: 1455 PDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVT-----SKKSKGESDDFHMDFDSAVAPR 1509
R+ + D +S+ KI VT S K K E D MD
Sbjct: 1115 --------RKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKI 1166
Query: 1510 AKSVRAKK 1517
+ S AKK
Sbjct: 1167 SLSAPAKK 1174
Score = 37.4 bits (85), Expect = 0.11
Identities = 80/387 (20%), Positives = 138/387 (35%), Gaps = 67/387 (17%)
Query: 1163 PSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKA-KGKKTQMAEVLPSPRGQRVIP 1221
P W +D + E+ E K + + GK K T+ + ++ P
Sbjct: 1283 PQSKWDKD------DFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYP------- 1329
Query: 1222 RITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKKQKREPGTKTKKQTTLA 1281
E ++E +K +K K+ + E E K + R+ K+
Sbjct: 1330 ----EKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKEN---- 1381
Query: 1282 FKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFS-DFD 1340
P K+ P +S DR +++ NF + ++ R + K T S++DF+ + D
Sbjct: 1382 --PEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTR-ASSNKDFTPNRD 1438
Query: 1341 EKTD------------DE--DFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLEADDVKG 1386
+KTD DE + SP + K S S ++ KP++ DL
Sbjct: 1439 KKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDS--ASGQKNKPREE--RDLPKKGTGD 1494
Query: 1387 SVPLSSSPPATHFPDETEITNPVPKKN---VTVKKTAAKSQSSTSTTGAKKRAAPKGTKR 1443
S +SSP P + + T + N +V K K + A+ G K
Sbjct: 1495 SKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREK-HVLEARNNKESSGNKL 1553
Query: 1444 DPALNSGVSQ---------------KPDPAKTKNRRKRKPSTSDDSDSNFE----KIVSK 1484
LN +Q KP P + + R T + ++ FE + S+
Sbjct: 1554 LYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSE 1613
Query: 1485 AVTSKKSKGESDDFHMDFDSAVAPRAK 1511
+ S K + S + D + +AK
Sbjct: 1614 SNVSVKEEESSGNISKDLKDKIVEKAK 1640
Score = 37.0 bits (84), Expect = 0.15
Identities = 54/247 (21%), Positives = 95/247 (38%), Gaps = 46/247 (18%)
Query: 1091 KEAQQKVPDEEENEESDNEKET-EKSDSVTDSGPTFNYLLDMPLWYLTKEK-KDELCRLR 1148
K ++ ++N D EK E ++ SG Y+L+ P + KE+ ++ +
Sbjct: 1518 KRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKST 1577
Query: 1149 NEKEQELDTLKRKSPSDLWKE-DLATFIEELEAVEAKE----KQDEQVGLPGKG------ 1197
+ + +L R S SDL +E D A F + +++ K++E G K
Sbjct: 1578 VKPKPQLSHSSRLS-SDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIV 1636
Query: 1198 ---------------GKAKGKKTQMAEVLPS----PRGQRVIPRITIEMKAEAEKKNKKK 1238
G ++ + V PS P G + + AE++ KKK
Sbjct: 1637 EKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKK 1696
Query: 1239 IKNENTEGSPQEDGVELEGLKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSE 1298
K E + K + KK K+ GT+ + + + K KK K+N D E
Sbjct: 1697 KKKEKKKHK-----------KHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKN--KDKE 1743
Query: 1299 SDRSSDE 1305
++ D+
Sbjct: 1744 KEKEKDD 1750
>gi|33620769 retinoblastoma-binding protein 6 isoform 1 [Homo sapiens]
Length = 1792
Score = 53.1 bits (126), Expect = 2e-06
Identities = 82/382 (21%), Positives = 148/382 (38%), Gaps = 76/382 (19%)
Query: 1182 EAKEKQDEQVGLPGKGGK-------AKGKKTQ---MAEVLPSPRGQR------------- 1218
++KEK+ E GKG K KG++++ E+L + R R
Sbjct: 915 KSKEKESENAPGDGKGNKHKKHRKRRKGEESEGFLNPELLETSRKSREPTGVEENKTDSL 974
Query: 1219 -VIP----------------RITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQR 1261
V+P IT + +E +K+ + K K + + + DG + K+
Sbjct: 975 FVLPSRDDATPVRDEPMDAESITFKSVSEKDKRERDKPKAKGDKTKRKNDGSAV-SKKEN 1033
Query: 1262 LEKKQK--REPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDV--PPR---- 1313
+ K K +E ++++ + PIKK K+ P +D+ SS + + + PR
Sbjct: 1034 IVKPAKGPQEKVDGERERSPRSEPPIKKAKEETPKTDNTKSSSSSQKDEKITGTPRKAHS 1093
Query: 1314 -------ETEP-RRAATKTKFTMDLDSDE-DFSDFDEKTDDEDFVPSD--ASPPKTKTSP 1362
ET+P + K ++ D+ S++ + K +E P D K KT
Sbjct: 1094 KSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRKRKTEE 1153
Query: 1363 KLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPAT----HFPDETEITNPVPKKNVTVKK 1418
K +K+ + +S LE ++ P P T P++ +I+ P K + + +
Sbjct: 1154 KGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKISLSAPAKKIKLNR 1213
Query: 1419 TAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNF 1478
K ST K + K S K K K + +RK + ++ S S
Sbjct: 1214 ETGKKIGSTENISNTKEPSEK--------LESTSSKVKQEKVKGKVRRKVTGTEGSSSTL 1265
Query: 1479 EKIVSKAVTS----KKSKGESD 1496
S + T +KS+ ++D
Sbjct: 1266 VDYTSTSSTGGSPVRKSEEKTD 1287
Score = 47.4 bits (111), Expect = 1e-04
Identities = 77/308 (25%), Positives = 111/308 (36%), Gaps = 46/308 (14%)
Query: 1228 KAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKKQKREP-GTKTKKQTTLAFKPIK 1286
K KK++K+ K E +EG + +E ++ REP G + K +L P +
Sbjct: 929 KGNKHKKHRKRRKGEESEGFLNPELLETS--------RKSREPTGVEENKTDSLFVLPSR 980
Query: 1287 KGKK--RNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDF----- 1339
R+ D+ES S D R+ +P+ KTK D + +
Sbjct: 981 DDATPVRDEPMDAESITFKSVSEKDKRERD-KPKAKGDKTKRKNDGSAVSKKENIVKPAK 1039
Query: 1340 --DEKTDDEDFVPSDASPPKTKT---SPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSP 1394
EK D E + PP K +PK N KS S + + + G+ P
Sbjct: 1040 GPQEKVDGERERSPRSEPPIKKAKEETPKTDNT-----KSSSSSQKDEKITGT------P 1088
Query: 1395 PATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQK 1454
H E P K VKK +K S T +++A K P N G +K
Sbjct: 1089 RKAHSKSAKEHQETKPVKEEKVKKDYSKDVKSEKLTTKEEKAKKPNEKNKPLDNKGEKRK 1148
Query: 1455 PDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVT-----SKKSKGESDDFHMDFDSAVAPR 1509
R+ + D +S+ KI VT S K K E D MD
Sbjct: 1149 --------RKTEEKGVDKDFESSSMKISKLEVTEIVKPSPKRKMEPDTEKMDRTPEKDKI 1200
Query: 1510 AKSVRAKK 1517
+ S AKK
Sbjct: 1201 SLSAPAKK 1208
Score = 37.4 bits (85), Expect = 0.11
Identities = 80/387 (20%), Positives = 138/387 (35%), Gaps = 67/387 (17%)
Query: 1163 PSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKA-KGKKTQMAEVLPSPRGQRVIP 1221
P W +D + E+ E K + + GK K T+ + ++ P
Sbjct: 1317 PQSKWDKD------DFESEEEDVKSTQPISSVGKPASVIKNVSTKPSNIVKYP------- 1363
Query: 1222 RITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKKQKREPGTKTKKQTTLA 1281
E ++E +K +K K+ + E E K + R+ K+
Sbjct: 1364 ----EKESEPSEKIQKFTKDVSHEIIQHEVKSSKNSASSEKGKTKDRDYSVLEKEN---- 1415
Query: 1282 FKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFS-DFD 1340
P K+ P +S DR +++ NF + ++ R + K T S++DF+ + D
Sbjct: 1416 --PEKRKNSTQPEKESNLDRLNEQGNFKSLSQSSKEARTSDKHDSTR-ASSNKDFTPNRD 1472
Query: 1341 EKTD------------DE--DFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLEADDVKG 1386
+KTD DE + SP + K S S ++ KP++ DL
Sbjct: 1473 KKTDYDTREYSSSKRRDEKNELTRRKDSPSRNKDS--ASGQKNKPREE--RDLPKKGTGD 1528
Query: 1387 SVPLSSSPPATHFPDETEITNPVPKKN---VTVKKTAAKSQSSTSTTGAKKRAAPKGTKR 1443
S +SSP P + + T + N +V K K + A+ G K
Sbjct: 1529 SKKSNSSPSRDRKPHDHKATYDTKRPNEETKSVDKNPCKDREK-HVLEARNNKESSGNKL 1587
Query: 1444 DPALNSGVSQ---------------KPDPAKTKNRRKRKPSTSDDSDSNFE----KIVSK 1484
LN +Q KP P + + R T + ++ FE + S+
Sbjct: 1588 LYILNPPETQVEKEQITGQIDKSTVKPKPQLSHSSRLSSDLTRETDEAAFEPDYNESDSE 1647
Query: 1485 AVTSKKSKGESDDFHMDFDSAVAPRAK 1511
+ S K + S + D + +AK
Sbjct: 1648 SNVSVKEEESSGNISKDLKDKIVEKAK 1674
Score = 37.0 bits (84), Expect = 0.15
Identities = 54/247 (21%), Positives = 95/247 (38%), Gaps = 46/247 (18%)
Query: 1091 KEAQQKVPDEEENEESDNEKET-EKSDSVTDSGPTFNYLLDMPLWYLTKEK-KDELCRLR 1148
K ++ ++N D EK E ++ SG Y+L+ P + KE+ ++ +
Sbjct: 1552 KRPNEETKSVDKNPCKDREKHVLEARNNKESSGNKLLYILNPPETQVEKEQITGQIDKST 1611
Query: 1149 NEKEQELDTLKRKSPSDLWKE-DLATFIEELEAVEAKE----KQDEQVGLPGKG------ 1197
+ + +L R S SDL +E D A F + +++ K++E G K
Sbjct: 1612 VKPKPQLSHSSRLS-SDLTRETDEAAFEPDYNESDSESNVSVKEEESSGNISKDLKDKIV 1670
Query: 1198 ---------------GKAKGKKTQMAEVLPS----PRGQRVIPRITIEMKAEAEKKNKKK 1238
G ++ + V PS P G + + AE++ KKK
Sbjct: 1671 EKAKESLDTAAVVQVGISRNQSHSSPSVSPSRSHSPSGSQTRSHSSSASSAESQDSKKKK 1730
Query: 1239 IKNENTEGSPQEDGVELEGLKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSE 1298
K E + K + KK K+ GT+ + + + K KK K+N D E
Sbjct: 1731 KKKEKKKHK-----------KHKKHKKHKKHAGTEVELEKSQKHKHKKKKSKKN--KDKE 1777
Query: 1299 SDRSSDE 1305
++ D+
Sbjct: 1778 KEKEKDD 1784
>gi|217330641 IWS1 homolog [Homo sapiens]
Length = 819
Score = 52.8 bits (125), Expect = 3e-06
Identities = 100/435 (22%), Positives = 165/435 (37%), Gaps = 83/435 (19%)
Query: 1097 VPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELD 1156
V ENE SD E K VTDS D PL + + E L +K+ + +
Sbjct: 45 VERHSENETSDREDGLPKGHHVTDSEN------DEPLNLNASDSESE--ELHRQKDSDSE 96
Query: 1157 TLKRKSP--SDLWKEDLATFIEELEAVEAK-----EKQDEQVGLPGKG--------GKAK 1201
+ +R P SD ED+ + E+ E + + ++E++ L G GK
Sbjct: 97 SEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEEL-LNGHASDSENEDVGKHP 155
Query: 1202 GKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQR 1261
+++ E+ SP +E E K +I + +E P+ + E +
Sbjct: 156 ASDSEIEELQKSPASD-----------SETEDALKPQISDSESEEPPRHQASDSENEEPP 204
Query: 1262 LEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESD-----RSSDESNFDVP-PRET 1315
+ E K Q SDSES+ ++SD N ++P PR +
Sbjct: 205 KPRMSDSESEELPKPQV----------------SDSESEEPPRHQASDSENEELPKPRIS 248
Query: 1316 EPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPK--LSNKELK-PQ 1372
+ D +++E ++ ED + AS + + PK +S+ E + PQ
Sbjct: 249 DSESEDPPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQ 308
Query: 1373 KSVVSDLEADDV---KGSVPLSSSPPATHFPDETEITNP-------VPKK---NVTVKKT 1419
K SD E +D K + ++TE+ N + +K + ++
Sbjct: 309 KGPASDSETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEE 368
Query: 1420 AAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFE 1479
K Q S K+ K KR A+ +S D K ++ R S +DDSDS+
Sbjct: 369 EHKKQKMDSDEDEKEGEEEKVAKRKAAV---LSDSEDEEKASAKKSRVVSDADDSDSD-- 423
Query: 1480 KIVSKAVTSKKSKGE 1494
AV+ K K E
Sbjct: 424 -----AVSDKSGKRE 433
Score = 32.0 bits (71), Expect = 4.7
Identities = 63/307 (20%), Positives = 113/307 (36%), Gaps = 46/307 (14%)
Query: 1091 KEAQQKVPDEEENEE------SDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDEL 1144
+E + + ENEE SD+E E V+DS + P + + +EL
Sbjct: 188 EEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESE-----EPPRHQASDSENEEL 242
Query: 1145 CRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKAKGKK 1204
+ R + D R SD E+L + E +D P + + +
Sbjct: 243 PKPRISDSESEDP-PRHQASDSENEELPK-----PRISDSESED-----PPRNQASDSEN 291
Query: 1205 TQMAEVLPSPR---GQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQR 1261
E LP PR + P+ +E E ++ K K E+ + S +E+ +G
Sbjct: 292 ----EELPKPRVSDSESEGPQKGPASDSETEDASRHKQKPESDDDSDREN----KGEDTE 343
Query: 1262 LEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFD-----VPPRETE 1316
++ +K+ + ++ KK+ SD + +E + E E
Sbjct: 344 MQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDEDEKEGEEEKVAKRKAAVLSDSEDE 403
Query: 1317 PRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVV 1376
+ +A K++ D D + + D+ E + SD S + + KEL +K+
Sbjct: 404 EKASAKKSRVVSDADDSDSDAVSDKSGKREKTIASD--------SEEEAGKELSDKKNEE 455
Query: 1377 SDLEADD 1383
DL D
Sbjct: 456 KDLFGSD 462
>gi|55956788 nucleolin [Homo sapiens]
Length = 710
Score = 51.6 bits (122), Expect = 6e-06
Identities = 83/378 (21%), Positives = 141/378 (37%), Gaps = 37/378 (9%)
Query: 1144 LCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKAKGK 1203
+ +L + + D K P +ED EE+ E + E+V +P K GK K
Sbjct: 1 MVKLAKAGKNQGDPKKMAPPPKEVEEDSED--EEMSEDEEDDSSGEEVVIPQKKGK-KAA 57
Query: 1204 KTQMAEVLPSPRGQRVIPR------ITIEMKAEAE--KKNKKKIKNENTEG----SPQED 1251
T +V+ SP + + +T KA A KK K T G +P +
Sbjct: 58 ATSAKKVVVSPTKKVAVATPAKKAAVTPGKKAAATPAKKTVTPAKAVTTPGKKGATPGKA 117
Query: 1252 GVELEGLKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVP 1311
V G K + + G KK+ + + + + D E D DE ++
Sbjct: 118 LVATPGKKGAAIPAKGAKNGKNAKKEDS------DEEEDDDSEEDEEDDEDEDEDEDEIE 171
Query: 1312 PRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKL----SNK 1367
P + AA ++ D D ++D D D++ DD + + +P K K + K+ +
Sbjct: 172 PAAMKAAAAAPASEDEDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKKAAKVVPVKAKN 231
Query: 1368 ELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSST 1427
+ + D + DD +E E PV + KK AK +++
Sbjct: 232 VAEDEDEEEDDEDEDDDDDEDDEDDDDEDDEEEEEEEEEEPVKEAPGKRKKEMAKQKAAP 291
Query: 1428 STTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVT 1487
K+ +GT+ A N V + K+ + K SD N +V +
Sbjct: 292 EA----KKQKVEGTEPTTAFNLFVG---NLNFNKSAPELKTGISDVFAKNDLAVVDVRIG 344
Query: 1488 SKKSKGESDDFHMDFDSA 1505
+ G ++DF+SA
Sbjct: 345 MTRKFG-----YVDFESA 357
Score = 49.7 bits (117), Expect = 2e-05
Identities = 67/329 (20%), Positives = 118/329 (35%), Gaps = 56/329 (17%)
Query: 1085 DPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDEL 1144
DP K ++ D E+ E S++E++ + V + +KK +
Sbjct: 13 DPKKMAPPPKEVEEDSEDEEMSEDEEDDSSGEEV-----------------VIPQKKGKK 55
Query: 1145 CRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKE--KQDEQVGLPGKGGKAKG 1202
+ K+ + K+ + + K+ T ++ A AK+ + V PGK G G
Sbjct: 56 AAATSAKKVVVSPTKKVAVATPAKKAAVTPGKKAAATPAKKTVTPAKAVTTPGKKGATPG 115
Query: 1203 KKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRL 1262
K P +G A K K KN E S +E+ + E ++
Sbjct: 116 K---ALVATPGKKG------------AAIPAKGAKNGKNAKKEDSDEEEDDDSEEDEEDD 160
Query: 1263 EKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAAT 1322
E + + E + A P + + D E D +E + + ET P +
Sbjct: 161 EDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDDEEDDSEEEAMETTPAKGKK 220
Query: 1323 KTKFT-------------------MDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPK 1363
K D D DED D D++ D+E+ + P K +P
Sbjct: 221 AAKVVPVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDDDEDDEEEEEEEEEEP--VKEAPG 278
Query: 1364 LSNKELKPQKSVVSDLEADDVKGSVPLSS 1392
KE+ QK+ + + V+G+ P ++
Sbjct: 279 KRKKEMAKQKA-APEAKKQKVEGTEPTTA 306
Score = 32.3 bits (72), Expect = 3.6
Identities = 35/172 (20%), Positives = 70/172 (40%), Gaps = 16/172 (9%)
Query: 1086 PVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELC 1145
PVKA A+ + +E++ +E D++ E ++ D D + P+ ++K E+
Sbjct: 226 PVKAKNVAEDEDEEEDDEDEDDDDDEDDEDDDDEDDEEEEEEEEEEPVKEAPGKRKKEMA 285
Query: 1146 RLRNEKEQELDTLKRKSPSDLWK------------EDLATFIEELEAVEAKEKQDEQVGL 1193
+ + E + ++ P+ + +L T I ++ A D ++G+
Sbjct: 286 KQKAAPEAKKQKVEGTEPTTAFNLFVGNLNFNKSAPELKTGISDVFAKNDLAVVDVRIGM 345
Query: 1194 PGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEK-KNKKKIKNENT 1244
K G + + E G +V E+K E K K+ KK ++ T
Sbjct: 346 TRKFGYVDFESAEDLEKALELTGLKVFGN---EIKLEKPKGKDSKKERDART 394
>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
Length = 1173
Score = 50.4 bits (119), Expect = 1e-05
Identities = 79/353 (22%), Positives = 144/353 (40%), Gaps = 39/353 (11%)
Query: 1138 KEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAV-----EAKEKQDEQVG 1192
+E++ EL R + KEQE L+ K E A ++E+ + + E + ++++ G
Sbjct: 845 QEQEKELLRQKLLKEQEEKRLREKEEQKKLLEQRAQYVEKTKNILMFTGETEATKEKKRG 904
Query: 1193 LPGKGGKAKGKKTQMAEV--------LPSPRGQRVIPRITIEMKAEAEK--KNKKKIKNE 1242
G GG+ K + E LP + ++ E + E E+ + KKK +
Sbjct: 905 --GGGGRRSKKGGEFDEFVNDDTDDDLPISKKKKRRKGSGSEQEGEDEEGGERKKKKRRR 962
Query: 1243 NTEGSPQEDGVELEGLKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRS 1302
+ +G D E E + KK++ K K P KGK ++ S SD S
Sbjct: 963 HPKGEEGSDDDETENGPK--PKKRRPPKAEKKKAPKPERLPPSMKGKIKSKAIISSSDDS 1020
Query: 1303 SDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSP 1362
SDE + E PR + + + DSDE DE+ SD+ + K+
Sbjct: 1021 SDEDKLKIAD-EGHPRNSNSNS------DSDE-----DEQRKKCASSESDSDENQNKSGS 1068
Query: 1363 KLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAK 1422
+ + +P++ SD ++D + S P + D + + V+ +
Sbjct: 1069 EAGSPR-RPRRQ-RSDQDSDSDQPS--RKRRPSGSEQSDNESVQSGRSHSGVSENDSRPA 1124
Query: 1423 SQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSD 1475
S S+ S +++ + +G+ + SG +P+ + + + SDDSD
Sbjct: 1125 SPSAESDHESERGSDNEGSGQ----GSGNESEPEGSNNEASDRGSEHGSDDSD 1173
Score = 42.0 bits (97), Expect = 0.005
Identities = 68/296 (22%), Positives = 112/296 (37%), Gaps = 61/296 (20%)
Query: 1226 EMKAEAEKKNKKKIKNENTEGSPQEDGV-----ELEGLKQRLEKKQKREPGTKTKK---- 1276
E K EK+ +KK+ + + + + E E K EKK+ G ++KK
Sbjct: 861 EEKRLREKEEQKKLLEQRAQYVEKTKNILMFTGETEATK---EKKRGGGGGRRSKKGGEF 917
Query: 1277 -----QTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLD 1331
T PI K KKR S SE + +E R+ + RR K
Sbjct: 918 DEFVNDDTDDDLPISKKKKRRKGSGSEQEGEDEEGG----ERKKKKRRRHPK-------- 965
Query: 1332 SDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLS 1391
E+ SD DE ++ P K P + K+ P+ + +K +S
Sbjct: 966 -GEEGSDDDE---------TENGPKPKKRRPPKAEKKKAPKPERLPPSMKGKIKSKAIIS 1015
Query: 1392 SSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGV 1451
SS ++ D+ +I + +N + S S + +K+ A + D N
Sbjct: 1016 SSDDSSD-EDKLKIADEGHPRN-------SNSNSDSDEDEQRKKCASSESDSDENQNKSG 1067
Query: 1452 SQKPDPAKTKNRR------------KRKPSTSDDSDSNFEKIVSKAVTSKKSKGES 1495
S+ P + + +R KR+PS S+ SD+ E + S S S+ +S
Sbjct: 1068 SEAGSPRRPRRQRSDQDSDSDQPSRKRRPSGSEQSDN--ESVQSGRSHSGVSENDS 1121
>gi|115334679 retinoblastoma-binding protein 1 isoform III [Homo
sapiens]
Length = 1188
Score = 50.4 bits (119), Expect = 1e-05
Identities = 77/357 (21%), Positives = 133/357 (37%), Gaps = 47/357 (13%)
Query: 1142 DELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKAK 1201
+E CR N + + + + K + K+DL +EE ++ + E P + +
Sbjct: 397 EEYCRSANIQFRTVHHHEPKVKEE--KKDLEESMEEALKLDQEMPLTEVKSEPEENIDSN 454
Query: 1202 GKKTQMAEVLPSPRGQRVIPRITIEMKAE-AEKKNKKKIKNENTEGSPQEDGVELEGLKQ 1260
+ + L SPRG+R I R +K E E+K + K+K+ +TE +D E
Sbjct: 455 SESEREEIELKSPRGRRRIARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYE------ 508
Query: 1261 RLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRA 1320
EKK+ + L K K K++ +SD+ SDE E R
Sbjct: 509 TAEKKE---------NELLLGRKNTPKQKEKKIKKQEDSDKDSDEE------EEKSQERE 553
Query: 1321 ATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLE 1380
T++K + + DE+ D P T T K+ K QK + ++
Sbjct: 554 ETESKCDSEGEEDEE----------------DMEPCLTGTKVKVKYGRGKTQKIYEASIK 597
Query: 1381 ADDVKGSVPL------SSSPPATHFPDETEITNPVPKKNVTVK-KTAAKSQSSTSTTGAK 1433
+ ++ L + + I P+ K K K AK++ + +
Sbjct: 598 STEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKR 657
Query: 1434 KRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKK 1490
K + P L S +S +K S S SDS E + K + +++
Sbjct: 658 DEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDSETEDALEKNLINEE 714
Score = 40.4 bits (93), Expect = 0.013
Identities = 101/482 (20%), Positives = 172/482 (35%), Gaps = 99/482 (20%)
Query: 1086 PVKAWKEAQQKVPDEEENEESDNEKETEK---------------------------SDSV 1118
P K K+ + D E++E+ D E++ K SDS
Sbjct: 637 PKKKQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSC 696
Query: 1119 TDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEEL 1178
+ T + L+ L KDEL + N + +LD K + + KE+ T ++ L
Sbjct: 697 SSDSETED-ALEKNLINEELSLKDELEKNENLNDDKLDEENPKISAHILKENDRTQMQPL 755
Query: 1179 EAVEAKEKQDEQV--------------------GLPGKGGKAKGKKTQMAEVLPSPRGQR 1218
E ++ + ++EQ+ GKG ++K K + + S GQ
Sbjct: 756 ETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQN 815
Query: 1219 VIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKK--QKREPGTKTKK 1276
E EA + N+N S ED ++ +++L++K + P K +
Sbjct: 816 ---EAGSEPHIEAHSLELSSLDNKNF-SSATEDEIDQCVKEKKLKRKILGQSSPEKKIRI 871
Query: 1277 QTTLAFKPIKKGKKRNPWSDSESDRSSD-ESNFDVPPRETE--PRRAATKTKFTMDLDSD 1333
+ + ++ + SE ++ + E +F+ RE E P A + L S+
Sbjct: 872 ENGMEMTNTVSQERTSDCIGSEGMKNLNFEQHFE---RENEGMPSLIAESNQCIQQLTSE 928
Query: 1334 EDFSDFDEKT-----DDEDFVP-------------SDASPPKTKTSPKLSNKELKPQKSV 1375
S +E +DED +P D K KTS + E S+
Sbjct: 929 RFDSPAEETVNIPLKEDEDAMPLIGPETLVCHEVDLDDLDEKDKTSIEDVAVESSESNSL 988
Query: 1376 VSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQ----------- 1424
VS A S + P T DE+ + V A +SQ
Sbjct: 989 VSIPPALPPVVQHNFSVASPLTLSQDESRSVKSESDITIEVDSIAEESQEGLCERESANG 1048
Query: 1425 -------SSTSTTGAKKRAAPKGTKRDPALNSGV---SQKPDPAKTKNRRKRKPSTSDDS 1474
+ S ++ + KG KR NSG+ QK P +T K + + +D+
Sbjct: 1049 FETNVASGTCSIIVQERESREKGQKRPSDGNSGLMAKKQKRTPKRTSAAAKNEKNGTDEL 1108
Query: 1475 DS 1476
D+
Sbjct: 1109 DN 1110
>gi|115334673 retinoblastoma-binding protein 1 isoform II [Homo
sapiens]
Length = 1203
Score = 50.4 bits (119), Expect = 1e-05
Identities = 77/357 (21%), Positives = 133/357 (37%), Gaps = 47/357 (13%)
Query: 1142 DELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKAK 1201
+E CR N + + + + K + K+DL +EE ++ + E P + +
Sbjct: 397 EEYCRSANIQFRTVHHHEPKVKEE--KKDLEESMEEALKLDQEMPLTEVKSEPEENIDSN 454
Query: 1202 GKKTQMAEVLPSPRGQRVIPRITIEMKAE-AEKKNKKKIKNENTEGSPQEDGVELEGLKQ 1260
+ + L SPRG+R I R +K E E+K + K+K+ +TE +D E
Sbjct: 455 SESEREEIELKSPRGRRRIARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYE------ 508
Query: 1261 RLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRA 1320
EKK+ + L K K K++ +SD+ SDE E R
Sbjct: 509 TAEKKE---------NELLLGRKNTPKQKEKKIKKQEDSDKDSDEE------EEKSQERE 553
Query: 1321 ATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLE 1380
T++K + + DE+ D P T T K+ K QK + ++
Sbjct: 554 ETESKCDSEGEEDEE----------------DMEPCLTGTKVKVKYGRGKTQKIYEASIK 597
Query: 1381 ADDVKGSVPL------SSSPPATHFPDETEITNPVPKKNVTVK-KTAAKSQSSTSTTGAK 1433
+ ++ L + + I P+ K K K AK++ + +
Sbjct: 598 STEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKR 657
Query: 1434 KRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKK 1490
K + P L S +S +K S S SDS E + K + +++
Sbjct: 658 DEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDSETEDALEKNLINEE 714
Score = 39.3 bits (90), Expect = 0.030
Identities = 104/483 (21%), Positives = 170/483 (35%), Gaps = 100/483 (20%)
Query: 1086 PVKAWKEAQQKVPDEEENEESDNEKETEK---------------------------SDSV 1118
P K K+ + D E++E+ D E++ K SDS
Sbjct: 637 PKKKQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSC 696
Query: 1119 TDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEEL 1178
+ T + L+ L KDEL + N + +LD K + + KE+ T ++ L
Sbjct: 697 SSDSETED-ALEKNLINEELSLKDELEKNENLNDDKLDEENPKISAHILKENDRTQMQPL 755
Query: 1179 EAVEAKEKQDEQV--------------------GLPGKGGKAKGKKTQMAEVLPSPRGQR 1218
E ++ + ++EQ+ GKG ++K K + + S GQ
Sbjct: 756 ETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQN 815
Query: 1219 VIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKK--QKREPGTKTKK 1276
E EA + N+N S ED ++ +++L++K + P K +
Sbjct: 816 ---EAGSEPHIEAHSLELSSLDNKNF-SSATEDEIDQCVKEKKLKRKILGQSSPEKKIRI 871
Query: 1277 QTTLAFKPIKKGKKRNPWSDSESDRSSD-ESNFDVPPRETE--PRRAATKTKFTMDLDSD 1333
+ + ++ + SE ++ + E +F+ RE E P A + L S+
Sbjct: 872 ENGMEMTNTVSQERTSDCIGSEGMKNLNFEQHFE---RENEGMPSLIAESNQCIQQLTSE 928
Query: 1334 EDFSDFDEKT-----DDEDFVP-------------SDASPPKTKTSPKLSNKELKPQKSV 1375
S +E +DED +P D K KTS + E S+
Sbjct: 929 RFDSPAEETVNIPLKEDEDAMPLIGPETLVCHEVDLDDLDEKDKTSIEDVAVESSESNSL 988
Query: 1376 VSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQ----------- 1424
VS A S + P T DE+ + V A +SQ
Sbjct: 989 VSIPPALPPVVQHNFSVASPLTLSQDESRSVKSESDITIEVDSIAEESQEGLCERESANG 1048
Query: 1425 -------SSTSTTGAKKRAAPKGTKRDPALNSGV---SQKPDPAKTKNRRK-RKPSTSDD 1473
+ S ++ + KG KR NSG+ QK P +T K K T
Sbjct: 1049 FETNVASGTCSIIVQERESREKGQKRPSDGNSGLMAKKQKRTPKRTSAAAKNEKNGTGQS 1108
Query: 1474 SDS 1476
SDS
Sbjct: 1109 SDS 1111
>gi|115334677 retinoblastoma-binding protein 1 isoform I [Homo
sapiens]
Length = 1257
Score = 50.4 bits (119), Expect = 1e-05
Identities = 77/357 (21%), Positives = 133/357 (37%), Gaps = 47/357 (13%)
Query: 1142 DELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKAK 1201
+E CR N + + + + K + K+DL +EE ++ + E P + +
Sbjct: 397 EEYCRSANIQFRTVHHHEPKVKEE--KKDLEESMEEALKLDQEMPLTEVKSEPEENIDSN 454
Query: 1202 GKKTQMAEVLPSPRGQRVIPRITIEMKAE-AEKKNKKKIKNENTEGSPQEDGVELEGLKQ 1260
+ + L SPRG+R I R +K E E+K + K+K+ +TE +D E
Sbjct: 455 SESEREEIELKSPRGRRRIARDVNSIKKEIEEEKTEDKLKDNDTENKDVDDDYE------ 508
Query: 1261 RLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRA 1320
EKK+ + L K K K++ +SD+ SDE E R
Sbjct: 509 TAEKKE---------NELLLGRKNTPKQKEKKIKKQEDSDKDSDEE------EEKSQERE 553
Query: 1321 ATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLE 1380
T++K + + DE+ D P T T K+ K QK + ++
Sbjct: 554 ETESKCDSEGEEDEE----------------DMEPCLTGTKVKVKYGRGKTQKIYEASIK 597
Query: 1381 ADDVKGSVPL------SSSPPATHFPDETEITNPVPKKNVTVK-KTAAKSQSSTSTTGAK 1433
+ ++ L + + I P+ K K K AK++ + +
Sbjct: 598 STEIDDGEVLYLVHYYGWNVRYDEWVKADRIIWPLDKGGPKKKQKKKAKNKEDSEKDEKR 657
Query: 1434 KRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKK 1490
K + P L S +S +K S S SDS E + K + +++
Sbjct: 658 DEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSCSSDSETEDALEKNLINEE 714
Score = 39.3 bits (90), Expect = 0.030
Identities = 104/483 (21%), Positives = 170/483 (35%), Gaps = 100/483 (20%)
Query: 1086 PVKAWKEAQQKVPDEEENEESDNEKETEK---------------------------SDSV 1118
P K K+ + D E++E+ D E++ K SDS
Sbjct: 637 PKKKQKKKAKNKEDSEKDEKRDEERQKSKRGRPPLKSTLSSNMPYGLSKTANSEGKSDSC 696
Query: 1119 TDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEEL 1178
+ T + L+ L KDEL + N + +LD K + + KE+ T ++ L
Sbjct: 697 SSDSETED-ALEKNLINEELSLKDELEKNENLNDDKLDEENPKISAHILKENDRTQMQPL 755
Query: 1179 EAVEAKEKQDEQV--------------------GLPGKGGKAKGKKTQMAEVLPSPRGQR 1218
E ++ + ++EQ+ GKG ++K K + + S GQ
Sbjct: 756 ETLKLEVGENEQIVQIFGNKMEKTEEVKKEAEKSPKGKGRRSKTKDLSLEIIKISSFGQN 815
Query: 1219 VIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKK--QKREPGTKTKK 1276
E EA + N+N S ED ++ +++L++K + P K +
Sbjct: 816 ---EAGSEPHIEAHSLELSSLDNKNF-SSATEDEIDQCVKEKKLKRKILGQSSPEKKIRI 871
Query: 1277 QTTLAFKPIKKGKKRNPWSDSESDRSSD-ESNFDVPPRETE--PRRAATKTKFTMDLDSD 1333
+ + ++ + SE ++ + E +F+ RE E P A + L S+
Sbjct: 872 ENGMEMTNTVSQERTSDCIGSEGMKNLNFEQHFE---RENEGMPSLIAESNQCIQQLTSE 928
Query: 1334 EDFSDFDEKT-----DDEDFVP-------------SDASPPKTKTSPKLSNKELKPQKSV 1375
S +E +DED +P D K KTS + E S+
Sbjct: 929 RFDSPAEETVNIPLKEDEDAMPLIGPETLVCHEVDLDDLDEKDKTSIEDVAVESSESNSL 988
Query: 1376 VSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQ----------- 1424
VS A S + P T DE+ + V A +SQ
Sbjct: 989 VSIPPALPPVVQHNFSVASPLTLSQDESRSVKSESDITIEVDSIAEESQEGLCERESANG 1048
Query: 1425 -------SSTSTTGAKKRAAPKGTKRDPALNSGV---SQKPDPAKTKNRRK-RKPSTSDD 1473
+ S ++ + KG KR NSG+ QK P +T K K T
Sbjct: 1049 FETNVASGTCSIIVQERESREKGQKRPSDGNSGLMAKKQKRTPKRTSAAAKNEKNGTGQS 1108
Query: 1474 SDS 1476
SDS
Sbjct: 1109 SDS 1111
>gi|4557509 cylicin 2 [Homo sapiens]
Length = 348
Score = 50.1 bits (118), Expect = 2e-05
Identities = 58/229 (25%), Positives = 99/229 (43%), Gaps = 37/229 (16%)
Query: 1078 IQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLT 1137
I++G + + + A K++++ D E+ ++S E E EK + D+ +
Sbjct: 147 IEKGKE-EKLDAKKDSKKGKKDAEKGKDSATESEDEKGGAKKDNKKDKKD---------S 196
Query: 1138 KEKKDELCRLRNEKE-QELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGK 1196
+ KD EK E D+ K K S K+ EL+AV+A EK+DE GK
Sbjct: 197 NKGKDSATESEGEKGGTEKDSKKGKKDSKKGKDSAI----ELQAVKADEKKDED----GK 248
Query: 1197 GGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELE 1256
KG +++ A + A+ KK KK K ++ S +D V+ E
Sbjct: 249 KDANKGDESKDA-----------------KKDAKEIKKGKKDKKKPSSTDSDSKDDVKKE 291
Query: 1257 GLKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDE 1305
K+ K K+ T+K++ + K KK K++ D++ + DE
Sbjct: 292 S-KKDATKDAKKVAKKDTEKESADSKKDAKKNAKKDAKKDAKKNAKKDE 339
Score = 47.4 bits (111), Expect = 1e-04
Identities = 78/352 (22%), Positives = 134/352 (38%), Gaps = 32/352 (9%)
Query: 1122 GPTFNYLLDMPLWYLTKEK-KDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEA 1180
GP NY+ P+ L+K+ + L K Q T +R PS + +++ + I+E E
Sbjct: 12 GPYDNYI---PVSELSKKSWNQQHFALLFPKPQRPGTKRRSKPSQI-RDNTVSIIDE-EQ 66
Query: 1181 VEAKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMK---AEAEKKNKK 1237
+ +Q P ++ + ++ V + R Q + P T+E+ AE KK +
Sbjct: 67 LRGDRRQ------PLWMYRSLMRISERPSVYLAARRQPLKPTRTVEVDSKAAEIGKKGED 120
Query: 1238 KIKNENTEGSPQEDGVELEGLKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDS 1297
K ++T S E LKQ + +K + K K++ A K KKGKK
Sbjct: 121 KTTQKDTTDSESE-------LKQGKKDSKKGKDIEKGKEEKLDAKKDSKKGKKDAEKGKD 173
Query: 1298 ESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPK 1357
+ S DE + + + + + + ++ ++ D K +D S +
Sbjct: 174 SATESEDEKGGAKKDNKKDKKDSNKGKDSATESEGEKGGTEKDSKKGKKDSKKGKDSAIE 233
Query: 1358 TKTSPKLSNKELKPQKSVVSDLEADDVKGSV------PLSSSPPATHFPDETEITNPVPK 1411
+ K+ +K E+ D K P++ D + K
Sbjct: 234 LQAVKADEKKDEDGKKDANKGDESKDAKKDAKEIKKGKKDKKKPSSTDSDSKDDVKKESK 293
Query: 1412 KNVT--VKKTAAKSQSSTSTTGAK--KRAAPKGTKRDPALNSGVSQKPDPAK 1459
K+ T KK A K S K K+ A K K+D N+ +K D K
Sbjct: 294 KDATKDAKKVAKKDTEKESADSKKDAKKNAKKDAKKDAKKNAKKDEKKDAKK 345
>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
Length = 1301
Score = 49.3 bits (116), Expect = 3e-05
Identities = 53/254 (20%), Positives = 96/254 (37%), Gaps = 21/254 (8%)
Query: 1287 KGKKRNPWSDS-----------ESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDED 1335
KGK + SDS SD S +SN ++ + + + D + D
Sbjct: 544 KGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSD 603
Query: 1336 FSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPP 1395
SD + +D D SD+S K+ +S S+ KS SD + D + S S
Sbjct: 604 SSDSSDSSDSSD--SSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSN 661
Query: 1396 ATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKP 1455
+++ D ++ ++ +++ S SS S+ + + ++ + +S S
Sbjct: 662 SSNSSDSSDSSDS--------SDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSS 713
Query: 1456 DPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRA 1515
D + + N +S+ SDS+ S + S S SD S + + S +
Sbjct: 714 DSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDS 773
Query: 1516 KKPIKYLEESDEDD 1529
SD +D
Sbjct: 774 SDSSDSSNSSDSND 787
Score = 46.2 bits (108), Expect = 2e-04
Identities = 55/241 (22%), Positives = 93/241 (38%), Gaps = 9/241 (3%)
Query: 1295 SDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDE-DFSDFDEKTDDEDFVPSDA 1353
SDS+S SSD SN + ++ + + DSD + SD +D D S
Sbjct: 816 SDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSN 875
Query: 1354 SPPKTKTSP--KLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPK 1411
S + +S + SN S SD ++ D S S S +++ D +E +N
Sbjct: 876 SSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNS---SDSSDSSNSSDSSESSNSSDN 932
Query: 1412 KNVTVKKTAA-KSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPST 1470
N + ++ S SS S+ + + + + +S S D + + + S+
Sbjct: 933 SNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSS 992
Query: 1471 --SDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDED 1528
SD SDS+ S + S S SD + S + + S + + SD
Sbjct: 993 DSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1052
Query: 1529 D 1529
D
Sbjct: 1053 D 1053
Score = 45.8 bits (107), Expect = 3e-04
Identities = 45/212 (21%), Positives = 84/212 (39%), Gaps = 5/212 (2%)
Query: 1295 SDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDAS 1354
SDS+S SSD SN + ++ ++ + + D D S+ + +D D S S
Sbjct: 708 SDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDS 767
Query: 1355 PPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNV 1414
+ +S + + ++ D S S+S ++ D ++ ++ +
Sbjct: 768 SDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSS---DSSDSSDSDSSNSS 824
Query: 1415 TVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDS 1474
++ S SS S+ + + G+ D + S S D + + + S SD S
Sbjct: 825 DSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDS-SDSS 883
Query: 1475 DSNFEKIVS-KAVTSKKSKGESDDFHMDFDSA 1505
DSN S + +S S +S D DS+
Sbjct: 884 DSNESSNSSDSSDSSNSSDSDSSDSSNSSDSS 915
Score = 41.2 bits (95), Expect = 0.008
Identities = 59/400 (14%), Positives = 130/400 (32%), Gaps = 23/400 (5%)
Query: 1099 DEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTL 1158
D +++ SD+ ++ SDS +DS + + + + D + D+
Sbjct: 589 DSSDSDSSDSSNSSDSSDS-SDSSDSSD----------SSDSSDSKSDSSKSESDSSDSD 637
Query: 1159 KRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQR 1218
+ SD D + + ++ + D + + ++ S
Sbjct: 638 SKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSN 697
Query: 1219 VIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKKQKREPGTKTKKQT 1278
++++ + N N+ S + + + + +
Sbjct: 698 SSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSD 757
Query: 1279 TLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDS--DEDF 1336
+ N S+S SSD S+ + ++ + + DS D
Sbjct: 758 S--------SDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDS 809
Query: 1337 SDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPA 1396
SD + +D + SD+S + S SN S SD D S+S +
Sbjct: 810 SDSSDSSDSDSSNSSDSS--NSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDS 867
Query: 1397 THFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKPD 1456
+ D + ++ + ++ S S++++ + + + + NS S +
Sbjct: 868 SDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESS 927
Query: 1457 PAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESD 1496
+ + ++SD SDS+ S + S S SD
Sbjct: 928 NSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSD 967
Score = 41.2 bits (95), Expect = 0.008
Identities = 38/204 (18%), Positives = 74/204 (36%), Gaps = 1/204 (0%)
Query: 1295 SDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDAS 1354
SDS S +S+ E+ ++ + + D D SD + +D D S S
Sbjct: 1064 SDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNS 1123
Query: 1355 PPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNV 1414
+ +S + + E+ D S S S ++ D ++ ++ +
Sbjct: 1124 SDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDS 1183
Query: 1415 TVKKTAA-KSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDD 1473
+ ++ S SS S+ + + + + +S S + N +SD
Sbjct: 1184 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDS 1243
Query: 1474 SDSNFEKIVSKAVTSKKSKGESDD 1497
SDS+ S + S S +S+D
Sbjct: 1244 SDSSNSSDSSDSSDSSDSTSDSND 1267
Score = 40.8 bits (94), Expect = 0.010
Identities = 44/238 (18%), Positives = 89/238 (37%), Gaps = 4/238 (1%)
Query: 1295 SDSESDRSSDESNF-DVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDA 1353
+ S+S SSD SN D + ++ + + D D SD + ++ D S
Sbjct: 952 NSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1011
Query: 1354 SPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKN 1413
S + +S ++ + ++ D S S S +++ D ++ ++ +
Sbjct: 1012 SSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSD 1071
Query: 1414 VTVKKTAAKSQSSTSTTGAKKRA--APKGTKRDPALNSGVSQKPDPAKTKNRRKRKPSTS 1471
+ ++ S S+ ++ + + + D + +S S D + + N S S
Sbjct: 1072 SSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDS-S 1130
Query: 1472 DDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDD 1529
D SDS+ S + S +S SD S + + S + + SD D
Sbjct: 1131 DSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSD 1188
Score = 40.4 bits (93), Expect = 0.013
Identities = 80/398 (20%), Positives = 142/398 (35%), Gaps = 49/398 (12%)
Query: 1177 ELEAVEAKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNK 1236
E++ + + ++ G+P G + + TQ L +RV RIT E + A K++
Sbjct: 316 EVDGDKTSKSEENSAGIPEDNGSQRIEDTQK---LNHRESKRVENRITKESETHAVGKSQ 372
Query: 1237 KK---IK----------------NENTEGSPQ------EDGVELEGLKQRLEKK-QKREP 1270
K IK NE E Q + V+ +G +E QK EP
Sbjct: 373 DKGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEP 432
Query: 1271 GTKTKKQTTLAFKPIKKGKKRNPWSDS----ESDRSSDESNFDVPPRETEPRRAATKTKF 1326
G K T G + D + SSDESN + ++++
Sbjct: 433 GNKVGHSNT-GSDSNSDGYDSYDFDDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDA 491
Query: 1327 TMDLDSDEDF---SDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLEADD 1383
+ + D +D SD DD+ SD + + + N + S ++ D
Sbjct: 492 SYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSD 551
Query: 1384 VKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKR 1443
S +SS + ++ +N + + ++ S S +S + ++
Sbjct: 552 SDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSS 611
Query: 1444 DPALNSGVSQ-KPDPAKTKNRRKRKPS-----------TSDDSDSNFEKIVSKAVTSKKS 1491
D + +S S K D +K+++ S +SD+SDS+ S + S S
Sbjct: 612 DSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDS 671
Query: 1492 KGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDD 1529
SD S + + S + + + SD D
Sbjct: 672 SDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSD 709
Score = 40.4 bits (93), Expect = 0.013
Identities = 44/238 (18%), Positives = 85/238 (35%), Gaps = 6/238 (2%)
Query: 1292 NPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPS 1351
N S+S SSD S+ ++ ++ + + D D SD + +D D S
Sbjct: 1029 NSSDSSDSSDSSDSSDSS----DSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSES 1084
Query: 1352 DASPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPK 1411
S + +S + + ++ D S S S ++ D ++ +N
Sbjct: 1085 SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDS 1144
Query: 1412 KNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPSTS 1471
+ + +++ S SS S+ + + + + NS S + + +S
Sbjct: 1145 SDSS--ESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSS 1202
Query: 1472 DDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDD 1529
D SDS+ S + S S SD + S + + S + + SD D
Sbjct: 1203 DSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSD 1260
Score = 39.7 bits (91), Expect = 0.023
Identities = 42/213 (19%), Positives = 77/213 (36%), Gaps = 10/213 (4%)
Query: 1297 SESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPP 1356
SES SSD SN ++ ++ + + D D SD +D D S S
Sbjct: 1082 SESSDSSDSSNSS----DSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSD 1137
Query: 1357 KTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTV 1416
+ +S + E ++ D S S S +++ D ++ ++ + +
Sbjct: 1138 SSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSD 1197
Query: 1417 KKTAAKSQSSTSTTGAKKRA-----APKGTKRDPALNSGVSQKPDPAKTKNRRKRKPSTS 1471
++ S S+ ++ + + + D +S S D + + N S S
Sbjct: 1198 SSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDS-S 1256
Query: 1472 DDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDS 1504
D SDS + SK G ++ D DS
Sbjct: 1257 DSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDS 1289
Score = 39.3 bits (90), Expect = 0.030
Identities = 47/239 (19%), Positives = 88/239 (36%), Gaps = 7/239 (2%)
Query: 1295 SDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDS-DEDFSDFDEKTDDEDFVPSDA 1353
+ S+S SSD SN ++ ++ + + +S D D SD +D D S
Sbjct: 863 NSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNSSDSSD---SSN 919
Query: 1354 SPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKN 1413
S +++S N + ++ D S S+S +++ D ++ + +
Sbjct: 920 SSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDS 979
Query: 1414 VTVKKTAAKSQSSTSTTGA-KKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPST-- 1470
++ S SS S+ + ++ D + +S S + + + N S+
Sbjct: 980 SNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDS 1039
Query: 1471 SDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDD 1529
SD SDS+ S + S S SD S + + S + SD D
Sbjct: 1040 SDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSD 1098
Score = 39.3 bits (90), Expect = 0.030
Identities = 48/243 (19%), Positives = 93/243 (38%), Gaps = 8/243 (3%)
Query: 1292 NPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPS 1351
N SES SSD SN ++ ++ + + D + D S+ + +D S
Sbjct: 919 NSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSN-SSDSSNSSDSSNSSDSSDSNSSDSS 977
Query: 1352 DASPPKTKTSPKLSNKELKPQKSVVSDLEAD-----DVKGSVPLSSSPPATHFPDETEIT 1406
D+S + S+ S S +D D S S+S +++ D ++ +
Sbjct: 978 DSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSS 1037
Query: 1407 NPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKR 1466
+ + + ++ S +S+ ++ + ++ D + +S S+ D + + N
Sbjct: 1038 DSSDSSDSSDSSDSSDSSNSSDSSDSSD-SSDSSDSSDSSDSSDSSESSDSSDSSNSSDS 1096
Query: 1467 KPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYLEESD 1526
S SD SDS+ S + S S SD S + + S + + + SD
Sbjct: 1097 SDS-SDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSD 1155
Query: 1527 EDD 1529
D
Sbjct: 1156 SSD 1158
Score = 36.2 bits (82), Expect = 0.25
Identities = 44/213 (20%), Positives = 83/213 (38%), Gaps = 10/213 (4%)
Query: 1292 NPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDS-DEDFSDFDEKTDDEDFVP 1350
N S+S SSD S+ ++ ++ + + DS D SD + +D +
Sbjct: 664 NSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNS 723
Query: 1351 SDASPPKTKTSPKLSNKELKPQKSVVSDL-EADDVKGSVPLSSSPPATHFPDETEITNPV 1409
SD+ + S SN S S+ ++ D S S S ++ D ++ +N
Sbjct: 724 SDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSS 783
Query: 1410 PKKNVTVKKTAA-KSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKP 1468
+ + ++ S SS S+ + + + D + +S S D + + N
Sbjct: 784 DSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSN------ 837
Query: 1469 STSDDSDSNFEKIVSKAVTSKKSKGESDDFHMD 1501
+SD SDS+ S + +S +S + D
Sbjct: 838 -SSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSD 869
>gi|21361272 myeloid/lymphoid or mixed-lineage leukemia (trithorax
homolog, Drosophila); translocated to, 1 [Homo sapiens]
Length = 559
Score = 48.9 bits (115), Expect = 4e-05
Identities = 60/263 (22%), Positives = 105/263 (39%), Gaps = 26/263 (9%)
Query: 1281 AFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETE-PRRAATKTKFTMDLDSDEDFSDF 1339
AF KK K + D+ + S V E PR+ + + +L+ ++ S
Sbjct: 168 AFSDPKKTKPSHGSKDANKESSKTSKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSK 227
Query: 1340 DEKTD-DEDFVPSDASPPKTKTS---PKLSNKELKPQKSVVSDLEADDVKGSVPLS-SSP 1394
D E +P + P K + PK++ KE K LE+ KG P P
Sbjct: 228 DTSRKLGEGRLPKEEKAPPPKAAFKEPKMALKETK--------LESTSPKGGPPPPPPPP 279
Query: 1395 P--ATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSG-- 1450
P ++ P + P KK KK+++K S T + ++ + + PA +
Sbjct: 280 PRASSKRPATADSPKPSAKKQ---KKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSST 336
Query: 1451 ----VSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSAV 1506
V + +P + K + + S S+D +++F+ +++ S S DF+ +
Sbjct: 337 RGEKVKAESEPREAKKALEVEESNSED-EASFKSESAQSSPSNSSSSSDSSSDSDFEPSQ 395
Query: 1507 APRAKSVRAKKPIKYLEESDEDD 1529
+R+ EESDEDD
Sbjct: 396 NHSQGPLRSMVEDLQSEESDEDD 418
Score = 36.6 bits (83), Expect = 0.19
Identities = 64/299 (21%), Positives = 104/299 (34%), Gaps = 45/299 (15%)
Query: 1084 SDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDE 1143
S P K KE +++ + E++ S E E E++ S D T K E
Sbjct: 192 SKPHKVTKEHRERPRKDSESKSSSKELEREQAKSSKD----------------TSRKLGE 235
Query: 1144 LCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKAKG- 1202
RL E++ K P KE +LE+ K P + +
Sbjct: 236 -GRLPKEEKAPPPKAAFKEPKMALKET------KLESTSPKGGPPPPPPPPPRASSKRPA 288
Query: 1203 -----KKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNEN-TEGSPQEDGVELE 1256
K + + S +G R P + + + +KK K+++ T G + E
Sbjct: 289 TADSPKPSAKKQKKSSSKGSRSAPGTSPRTSSSSSFSDKKPAKDKSSTRGEKVKAESEPR 348
Query: 1257 GLKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNF-------D 1309
K+ LE ++ + K + P + SDS+ + S + S D
Sbjct: 349 EAKKALEVEESNSEDEASFKSESAQSSPSNSSSSSDSSSDSDFEPSQNHSQGPLRSMVED 408
Query: 1310 VPPRETEP------RRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSP 1362
+ E++ AA KT DS FSD + + +PS PP K P
Sbjct: 409 LQSEESDEDDSSSGEEAAGKTN--PGRDSRLSFSDSESDNSADSSLPSREPPPPQKPPP 465
>gi|122937247 unc-13 homolog A [Homo sapiens]
Length = 1791
Score = 47.8 bits (112), Expect = 8e-05
Identities = 43/164 (26%), Positives = 72/164 (43%), Gaps = 9/164 (5%)
Query: 1098 PDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDE-LCRLRNEKEQELD 1156
PDE + SD E E ++ DS + +Y D P W +E+ +E L E+E D
Sbjct: 370 PDEHSLQGSDMEDERDR-DSYHSCHSSVSYHKDSPRWDQDEEELEEDLEDFLEEEELPED 428
Query: 1157 TLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLP----GKGGKAKGKKTQ---MAE 1209
+ + + +DL ++ + + A+ K +++ LP GK KA T+ MA+
Sbjct: 429 EEELEEEEEEVPDDLGSYAQREDVAVAEPKDFKRISLPPAAPGKEDKAPVAPTEAPDMAK 488
Query: 1210 VLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGV 1253
V P P +P +AE K + E+ EG +D +
Sbjct: 489 VAPKPATPDKVPAAEQIPEAEPPKDEESFRPREDEEGQEGQDSM 532
>gi|150170670 piccolo isoform 2 [Homo sapiens]
Length = 4935
Score = 47.0 bits (110), Expect = 1e-04
Identities = 79/339 (23%), Positives = 136/339 (40%), Gaps = 62/339 (18%)
Query: 1048 LNNQARFILEKIDGKI----IIENKPKKELIKVLIQRGYDSDP------VKAWKEAQQKV 1097
L +Q + EK++G++ + E K + ++ L S P K KE Q
Sbjct: 1265 LKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPP 1324
Query: 1098 ----PDEEENEESDNEKETEKSDSVTDSGP---------------TFNYLLDMPLWYLTK 1138
PD+ E + EKE +KSD+ + P + L ++P T
Sbjct: 1325 CTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTD 1384
Query: 1139 EKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGG 1198
E KD L L+ K+ SPSDL K + +T + LEA +A DE+
Sbjct: 1385 E-KDILKGLK--KDSFSQESSPSSPSDLAKLE-STVLSILEA-QASTLADEK-------- 1431
Query: 1199 KAKGKKTQMAEVLP-SPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEG 1257
KKTQ EV P P+ Q ++ ++ ++ K+ + E + ++ ++
Sbjct: 1432 --SEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPS 1489
Query: 1258 LKQRLEKKQ-------KREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDV 1310
K EK + +REP ++ + P+ + K+R S SD E +
Sbjct: 1490 SKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGS 1549
Query: 1311 PPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFV 1349
E R K +++ +DED S ++D++F+
Sbjct: 1550 GEEEDFIR------KQIIEMSADEDASG----SEDDEFI 1578
Score = 32.7 bits (73), Expect = 2.8
Identities = 38/151 (25%), Positives = 55/151 (36%), Gaps = 11/151 (7%)
Query: 1350 PSDASPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPV 1409
P PP P L P EAD + P P D+ + +
Sbjct: 698 PEPKKPPPLVKQPTLHGS---PSAKAKQPPEADSLSKPAP-PKEPSVPSEQDKAPVADDK 753
Query: 1410 PKKNVTVKKTAAKSQSSTSTT----GAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRK 1465
PK+ VK T SS++TT + K + K P L + S KP + K
Sbjct: 754 PKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTD-SAKPSQSFPPTGEK 812
Query: 1466 RKP--STSDDSDSNFEKIVSKAVTSKKSKGE 1494
P S + ++ KI+S S +SKG+
Sbjct: 813 VSPFDSKAIPRPASDSKIISHPGPSSESKGQ 843
Score = 32.3 bits (72), Expect = 3.6
Identities = 78/393 (19%), Positives = 143/393 (36%), Gaps = 70/393 (17%)
Query: 1181 VEAKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNK---- 1236
V+ +KQ+++V K + +K + +V + +++ P +T + K E K K
Sbjct: 1154 VKLVKKQEQEV-------KTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKAS 1206
Query: 1237 ----KKIKNENTEGSPQEDGVELEGLKQRLEKK------QKREPGTKT------------ 1274
KK E + P+E+ + E K LE+K +K P KT
Sbjct: 1207 ALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLK 1266
Query: 1275 --------KKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTK- 1325
K + +A K +++GK+ P + E S + P+E + K +
Sbjct: 1267 SQVQIAEEKLEGRVAPKTVQEGKQ--PQTKMEGLPSGTPQSL---PKEDDKTTKTIKEQP 1321
Query: 1326 ---FTMDLDSDEDFSDFDEKTDDEDFVPSDASP--PKTKTSPKLSNKELKPQKSVVSDLE 1380
T D E + EK DD+ S P P+ + S+ + + L
Sbjct: 1322 QPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLI 1381
Query: 1381 ADDVKGSVPLSSSPPATHFPDETEITNP--VPKKNVTVKKTAAKSQSSTSTTGAKKRAAP 1438
D K + F E+ ++P + K TV S+ + ++K+ P
Sbjct: 1382 PTDEK---DILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQP 1438
Query: 1439 KGTKRDPALNSGVSQKPDPAK--TKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESD 1496
+ + +Q T + + K S + D+ F+K + + S K E
Sbjct: 1439 HEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDT-FKKDSQQDIPSSKDHKEKS 1497
Query: 1497 DFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDD 1529
+F D + ++P +EES E +
Sbjct: 1498 EFVDDITT----------RREPYDSVEESSESE 1520
Score = 31.6 bits (70), Expect = 6.2
Identities = 55/241 (22%), Positives = 91/241 (37%), Gaps = 21/241 (8%)
Query: 1247 SPQEDGVELEGLKQRLEKKQKREP-GTKTKKQTTLAFKPIKK--GKKRNPWSDSESDRS- 1302
S E E KQ++ +K++ +P G KPI K G R+P + +S
Sbjct: 180 SDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSI 239
Query: 1303 ---SDESNFDVPPRETEPRRAATKTKFT--MDLDSDEDFSDFDEKTDD-------EDFVP 1350
E PP +P + T+T T L D S K D + +P
Sbjct: 240 SSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLP 299
Query: 1351 SDASPPKTKTSP-KLSNKELKPQKSVVSDLEADDVKGSV--PLSSSPPATHFPDETEITN 1407
S + PP + +P K ++ +KS + + PL+ P P + T
Sbjct: 300 SPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTT 359
Query: 1408 PVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRK 1467
P + + K A Q + S + ++ PK + P + +Q+P PAK ++
Sbjct: 360 KPPAQPLGPAKPPA--QQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGT 417
Query: 1468 P 1468
P
Sbjct: 418 P 418
>gi|150378539 piccolo isoform 1 [Homo sapiens]
Length = 5142
Score = 47.0 bits (110), Expect = 1e-04
Identities = 79/339 (23%), Positives = 136/339 (40%), Gaps = 62/339 (18%)
Query: 1048 LNNQARFILEKIDGKI----IIENKPKKELIKVLIQRGYDSDP------VKAWKEAQQKV 1097
L +Q + EK++G++ + E K + ++ L S P K KE Q
Sbjct: 1265 LKSQVQIAEEKLEGRVAPKTVQEGKQPQTKMEGLPSGTPQSLPKEDDKTTKTIKEQPQPP 1324
Query: 1098 ----PDEEENEESDNEKETEKSDSVTDSGP---------------TFNYLLDMPLWYLTK 1138
PD+ E + EKE +KSD+ + P + L ++P T
Sbjct: 1325 CTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLIPTD 1384
Query: 1139 EKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGG 1198
E KD L L+ K+ SPSDL K + +T + LEA +A DE+
Sbjct: 1385 E-KDILKGLK--KDSFSQESSPSSPSDLAKLE-STVLSILEA-QASTLADEK-------- 1431
Query: 1199 KAKGKKTQMAEVLP-SPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEG 1257
KKTQ EV P P+ Q ++ ++ ++ K+ + E + ++ ++
Sbjct: 1432 --SEKKTQPHEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDTFKKDSQQDIPS 1489
Query: 1258 LKQRLEKKQ-------KREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDV 1310
K EK + +REP ++ + P+ + K+R S SD E +
Sbjct: 1490 SKDHKEKSEFVDDITTRREPYDSVEESSESENSPVPQRKRRTSVGSSSSDEYKQEDSQGS 1549
Query: 1311 PPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFV 1349
E R K +++ +DED S ++D++F+
Sbjct: 1550 GEEEDFIR------KQIIEMSADEDASG----SEDDEFI 1578
Score = 32.7 bits (73), Expect = 2.8
Identities = 38/151 (25%), Positives = 55/151 (36%), Gaps = 11/151 (7%)
Query: 1350 PSDASPPKTKTSPKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPV 1409
P PP P L P EAD + P P D+ + +
Sbjct: 698 PEPKKPPPLVKQPTLHGS---PSAKAKQPPEADSLSKPAP-PKEPSVPSEQDKAPVADDK 753
Query: 1410 PKKNVTVKKTAAKSQSSTSTT----GAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRK 1465
PK+ VK T SS++TT + K + K P L + S KP + K
Sbjct: 754 PKQPKMVKPTTDLVSSSSATTKPDIPSSKVQSQAEEKTTPPLKTD-SAKPSQSFPPTGEK 812
Query: 1466 RKP--STSDDSDSNFEKIVSKAVTSKKSKGE 1494
P S + ++ KI+S S +SKG+
Sbjct: 813 VSPFDSKAIPRPASDSKIISHPGPSSESKGQ 843
Score = 32.3 bits (72), Expect = 3.6
Identities = 78/393 (19%), Positives = 143/393 (36%), Gaps = 70/393 (17%)
Query: 1181 VEAKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNK---- 1236
V+ +KQ+++V K + +K + +V + +++ P +T + K E K K
Sbjct: 1154 VKLVKKQEQEV-------KTEAEKVILEKVKETLSMEKIPPMVTTDQKQEESKLEKDKAS 1206
Query: 1237 ----KKIKNENTEGSPQEDGVELEGLKQRLEKK------QKREPGTKT------------ 1274
KK E + P+E+ + E K LE+K +K P KT
Sbjct: 1207 ALQEKKPLPEEKKLIPEEEKIRSEEKKPLLEEKKPTPEDKKLLPEAKTSAPEEQKHDLLK 1266
Query: 1275 --------KKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTK- 1325
K + +A K +++GK+ P + E S + P+E + K +
Sbjct: 1267 SQVQIAEEKLEGRVAPKTVQEGKQ--PQTKMEGLPSGTPQSL---PKEDDKTTKTIKEQP 1321
Query: 1326 ---FTMDLDSDEDFSDFDEKTDDEDFVPSDASP--PKTKTSPKLSNKELKPQKSVVSDLE 1380
T D E + EK DD+ S P P+ + S+ + + L
Sbjct: 1322 QPPCTAKPDQVEPGKEKTEKEDDKSDTSSSQQPKSPQGLSDTGYSSDGISSSLGEIPSLI 1381
Query: 1381 ADDVKGSVPLSSSPPATHFPDETEITNP--VPKKNVTVKKTAAKSQSSTSTTGAKKRAAP 1438
D K + F E+ ++P + K TV S+ + ++K+ P
Sbjct: 1382 PTDEK---DILKGLKKDSFSQESSPSSPSDLAKLESTVLSILEAQASTLADEKSEKKTQP 1438
Query: 1439 KGTKRDPALNSGVSQKPDPAK--TKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESD 1496
+ + +Q T + + K S + D+ F+K + + S K E
Sbjct: 1439 HEVSPEQPKDQEKTQSLSETLEITISEEEIKESQEERKDT-FKKDSQQDIPSSKDHKEKS 1497
Query: 1497 DFHMDFDSAVAPRAKSVRAKKPIKYLEESDEDD 1529
+F D + ++P +EES E +
Sbjct: 1498 EFVDDITT----------RREPYDSVEESSESE 1520
Score = 31.6 bits (70), Expect = 6.2
Identities = 55/241 (22%), Positives = 91/241 (37%), Gaps = 21/241 (8%)
Query: 1247 SPQEDGVELEGLKQRLEKKQKREP-GTKTKKQTTLAFKPIKK--GKKRNPWSDSESDRS- 1302
S E E KQ++ +K++ +P G KPI K G R+P + +S
Sbjct: 180 SDSEASQEETTKKQKVVQKEQGKPEGIIKPPLQQQPPKPIPKQQGPGRDPLQQDGTPKSI 239
Query: 1303 ---SDESNFDVPPRETEPRRAATKTKFT--MDLDSDEDFSDFDEKTDD-------EDFVP 1350
E PP +P + T+T T L D S K D + +P
Sbjct: 240 SSQQPEKIKSQPPGTGKPIQGPTQTPQTDHAKLPLQRDASRPQTKQADIVRGESVKPSLP 299
Query: 1351 SDASPPKTKTSP-KLSNKELKPQKSVVSDLEADDVKGSV--PLSSSPPATHFPDETEITN 1407
S + PP + +P K ++ +KS + + PL+ P P + T
Sbjct: 300 SPSKPPIQQPTPGKPPAQQPGHEKSQPGPAKPPAQPSGLTKPLAQQPGTVKPPVQPPGTT 359
Query: 1408 PVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRK 1467
P + + K A Q + S + ++ PK + P + +Q+P PAK ++
Sbjct: 360 KPPAQPLGPAKPPA--QQTGSEKPSSEQPGPKALAQPPGVGKTPAQQPGPAKPPTQQVGT 417
Query: 1468 P 1468
P
Sbjct: 418 P 418
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 [Homo
sapiens]
Length = 916
Score = 46.6 bits (109), Expect = 2e-04
Identities = 68/312 (21%), Positives = 120/312 (38%), Gaps = 39/312 (12%)
Query: 1199 KAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGL 1258
K + +K++M E L + + + + MK E KK + K E E +E + +
Sbjct: 461 KVEDEKSEMEEALTA-----ITEELAVSMKEE--KKEAAEEKEEEPEAEEEEVAAKKSPV 513
Query: 1259 KQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSD--SESDRSSDESNFDVPPRETE 1316
K + K E G K +++ + +G K + + SE + SS++ + ETE
Sbjct: 514 KATAPEV-KEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETE 572
Query: 1317 PR----RAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQ 1372
A K + ++ S+E + + D + P A P K+ + K P+
Sbjct: 573 AEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPK 632
Query: 1373 KSVVSDLEAD------DVKGSVPLSSSP-------PATHFPDETEITNPVPKKNVTVKKT 1419
V ++ + KG P+ SP P + P E + +PVPK V K+
Sbjct: 633 SPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKS 692
Query: 1420 AAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFE 1479
A+ G +K K K P ++ P ++K + E
Sbjct: 693 KAEVGK-----GEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVK-------E 740
Query: 1480 KIVSKAVTSKKS 1491
+ V++ VT KS
Sbjct: 741 EAVAEVVTITKS 752
Score = 40.8 bits (94), Expect = 0.010
Identities = 111/488 (22%), Positives = 182/488 (37%), Gaps = 112/488 (22%)
Query: 1066 ENKPKKELIKVLIQRGYDSDPVKAW----KEAQQKVPDEEENEESDNEKETEKSDSVTDS 1121
E +P+ E +V ++ PVKA KE + + +EE EE + E E KSD +
Sbjct: 496 EEEPEAEEEEVAAKKS----PVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEG 551
Query: 1122 GPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAV 1181
G KE E + E EQE + ++ EE EA
Sbjct: 552 GS-------------EKEGSSE----KEEGEQEEGETEAEAEG-----------EEAEAK 583
Query: 1182 EAKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKN 1241
E K+ +++ + K K + E SP +P K+ E+K K +
Sbjct: 584 EEKKVEEKSEEVATKEELVADAKVEKPEKAKSP-----VP------KSPVEEKGKSPVPK 632
Query: 1242 ENTEGSPQEDGVELEGLKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDR 1301
SP E+ + K +E+K K P K+ + +KGK S +
Sbjct: 633 -----SPVEEKGKSPVPKSPVEEKGK-SPVPKSPVE--------EKGK-------SPVSK 671
Query: 1302 SSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTS 1361
S E P ++ A +K + +E+ + E +E + P
Sbjct: 672 SPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKP------ 725
Query: 1362 PKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDET-EITNPVPKKNVTVKKTA 1420
K++ +K S ++ + V V ++ S H ET E P+ ++ +K
Sbjct: 726 -----KDVPEKKKAESPVKEEAVAEVVTITKS-VKVHLEKETKEEGKPLQQEK---EKEK 776
Query: 1421 AKSQSSTSTTGAKKRAAPKGT-KRDPALNSGVSQKPD-----PAKTKNRRKRKP------ 1468
A + + G+ K A KG+ K D A+N V K + K R + K
Sbjct: 777 AGGEGGSEEEGSDKGA--KGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGL 834
Query: 1469 --STSDD---SDSNFEK-IVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYL 1522
S +D+ D + EK +V+K V S+G D A KSV + ++
Sbjct: 835 DLSPADEKKGGDKSEEKVVVTKTVEKITSEGG--------DGATKYITKSVTVTQKVEEH 886
Query: 1523 EESDEDDL 1530
EE+ E+ L
Sbjct: 887 EETFEEKL 894
Score = 33.5 bits (75), Expect = 1.6
Identities = 52/245 (21%), Positives = 100/245 (40%), Gaps = 42/245 (17%)
Query: 1056 LEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKS 1115
+E+ K + +KE + ++ + V+ +E + VP++++ E E+ +
Sbjct: 687 VEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEV 746
Query: 1116 DSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQEL--------DTLKRKSPSDLW 1167
++T S +L KE K+E L+ EKE+E + K
Sbjct: 747 VTITKSVKV----------HLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSR 796
Query: 1168 KEDLATFIEELEAVEAKEKQDEQVGLPGKG-GKAKGKKTQMAEVLPSPRGQRVIPRITIE 1226
KED+A E VE KE+ +++ G G + KG T ++ P+ +
Sbjct: 797 KEDIAVNGE----VEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPA------------D 840
Query: 1227 MKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKK----QKREPGTKTKKQTTLAF 1282
K +K +K + + E E G +G + + K QK E +T ++ ++
Sbjct: 841 EKKGGDKSEEKVVVTKTVEKITSEGG---DGATKYITKSVTVTQKVEEHEETFEEKLVST 897
Query: 1283 KPIKK 1287
K ++K
Sbjct: 898 KKVEK 902
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 [Homo
sapiens]
Length = 540
Score = 46.6 bits (109), Expect = 2e-04
Identities = 68/312 (21%), Positives = 120/312 (38%), Gaps = 39/312 (12%)
Query: 1199 KAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGL 1258
K + +K++M E L + + + + MK E KK + K E E +E + +
Sbjct: 85 KVEDEKSEMEEALTA-----ITEELAVSMKEE--KKEAAEEKEEEPEAEEEEVAAKKSPV 137
Query: 1259 KQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSD--SESDRSSDESNFDVPPRETE 1316
K + K E G K +++ + +G K + + SE + SS++ + ETE
Sbjct: 138 KATAPEV-KEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETE 196
Query: 1317 PR----RAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQ 1372
A K + ++ S+E + + D + P A P K+ + K P+
Sbjct: 197 AEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPK 256
Query: 1373 KSVVSDLEAD------DVKGSVPLSSSP-------PATHFPDETEITNPVPKKNVTVKKT 1419
V ++ + KG P+ SP P + P E + +PVPK V K+
Sbjct: 257 SPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKS 316
Query: 1420 AAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFE 1479
A+ G +K K K P ++ P ++K + E
Sbjct: 317 KAEVGK-----GEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVK-------E 364
Query: 1480 KIVSKAVTSKKS 1491
+ V++ VT KS
Sbjct: 365 EAVAEVVTITKS 376
Score = 40.8 bits (94), Expect = 0.010
Identities = 111/488 (22%), Positives = 182/488 (37%), Gaps = 112/488 (22%)
Query: 1066 ENKPKKELIKVLIQRGYDSDPVKAW----KEAQQKVPDEEENEESDNEKETEKSDSVTDS 1121
E +P+ E +V ++ PVKA KE + + +EE EE + E E KSD +
Sbjct: 120 EEEPEAEEEEVAAKKS----PVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEG 175
Query: 1122 GPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAV 1181
G KE E + E EQE + ++ EE EA
Sbjct: 176 GS-------------EKEGSSE----KEEGEQEEGETEAEAEG-----------EEAEAK 207
Query: 1182 EAKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKN 1241
E K+ +++ + K K + E SP +P K+ E+K K +
Sbjct: 208 EEKKVEEKSEEVATKEELVADAKVEKPEKAKSP-----VP------KSPVEEKGKSPVPK 256
Query: 1242 ENTEGSPQEDGVELEGLKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDR 1301
SP E+ + K +E+K K P K+ + +KGK S +
Sbjct: 257 -----SPVEEKGKSPVPKSPVEEKGK-SPVPKSPVE--------EKGK-------SPVSK 295
Query: 1302 SSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTS 1361
S E P ++ A +K + +E+ + E +E + P
Sbjct: 296 SPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKP------ 349
Query: 1362 PKLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDET-EITNPVPKKNVTVKKTA 1420
K++ +K S ++ + V V ++ S H ET E P+ ++ +K
Sbjct: 350 -----KDVPEKKKAESPVKEEAVAEVVTITKS-VKVHLEKETKEEGKPLQQEK---EKEK 400
Query: 1421 AKSQSSTSTTGAKKRAAPKGT-KRDPALNSGVSQKPD-----PAKTKNRRKRKP------ 1468
A + + G+ K A KG+ K D A+N V K + K R + K
Sbjct: 401 AGGEGGSEEEGSDKGA--KGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGL 458
Query: 1469 --STSDD---SDSNFEK-IVSKAVTSKKSKGESDDFHMDFDSAVAPRAKSVRAKKPIKYL 1522
S +D+ D + EK +V+K V S+G D A KSV + ++
Sbjct: 459 DLSPADEKKGGDKSEEKVVVTKTVEKITSEGG--------DGATKYITKSVTVTQKVEEH 510
Query: 1523 EESDEDDL 1530
EE+ E+ L
Sbjct: 511 EETFEEKL 518
Score = 33.5 bits (75), Expect = 1.6
Identities = 52/245 (21%), Positives = 100/245 (40%), Gaps = 42/245 (17%)
Query: 1056 LEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKS 1115
+E+ K + +KE + ++ + V+ +E + VP++++ E E+ +
Sbjct: 311 VEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKAESPVKEEAVAEV 370
Query: 1116 DSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQEL--------DTLKRKSPSDLW 1167
++T S +L KE K+E L+ EKE+E + K
Sbjct: 371 VTITKSVKV----------HLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSR 420
Query: 1168 KEDLATFIEELEAVEAKEKQDEQVGLPGKG-GKAKGKKTQMAEVLPSPRGQRVIPRITIE 1226
KED+A E VE KE+ +++ G G + KG T ++ P+ +
Sbjct: 421 KEDIAVNGE----VEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPA------------D 464
Query: 1227 MKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKK----QKREPGTKTKKQTTLAF 1282
K +K +K + + E E G +G + + K QK E +T ++ ++
Sbjct: 465 EKKGGDKSEEKVVVTKTVEKITSEGG---DGATKYITKSVTVTQKVEEHEETFEEKLVST 521
Query: 1283 KPIKK 1287
K ++K
Sbjct: 522 KKVEK 526
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 46.2 bits (108), Expect = 2e-04
Identities = 79/434 (18%), Positives = 160/434 (36%), Gaps = 43/434 (9%)
Query: 1068 KPKKELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNY 1127
K KKE + S+ + K+ +Q E E+ + +EK + K+ +V + F+
Sbjct: 336 KEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEVESLKLPSEKNSNKAKTVEGTKEDFS- 394
Query: 1128 LLDMPLWYLT-----KEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVE 1182
L+D + LT +L + E+E+ T ++ +D E
Sbjct: 395 LIDSDVDGLTDITVSSVHTSDLSSFEEDTEEEVVTSDSMEEGEITSDD-----------E 443
Query: 1183 AKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNE 1242
K KQ++ + K K + A V + E+ E +++ K K E
Sbjct: 444 EKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEE 503
Query: 1243 NTEGSPQEDGVELEGLKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRS 1302
+ + +++LE+K+K++ KTK T KG+ R+ ES
Sbjct: 504 RL--------LRRQINREKLEEKRKQK-AEKTKSSKT-------KGQGRSSVDLEESSTK 547
Query: 1303 SDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSP 1362
S E +E R + K + +D + +E + + D S KTS
Sbjct: 548 SLEPK-AARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSKKKQQYEED-SKETLKTSE 605
Query: 1363 KLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAK 1422
+++ K +L+ K S PA + + + ++ ++ +
Sbjct: 606 HCEKEKISSSK----ELKHVHAKS----EPSKPARRLSESLHVVDENKNESKLEREHKRR 657
Query: 1423 SQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIV 1482
+ + G ++ + KR + +++P K+ + ++ D + + ++
Sbjct: 658 TSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKDDSETPHLKSLL 717
Query: 1483 SKAVTSKKSKGESD 1496
K V S K K E +
Sbjct: 718 KKEVKSSKEKPERE 731
Score = 38.5 bits (88), Expect = 0.050
Identities = 62/345 (17%), Positives = 137/345 (39%), Gaps = 24/345 (6%)
Query: 1091 KEAQQKVPDEEENEESDNEKETEKSDSVT--DSGPTFNYLLDMPLWYLTKEKKDELCRLR 1148
K++QQ ++ E ++ E+ SV D P Y++ + KE + RL
Sbjct: 774 KQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDE-NVRKENNKKERRLS 832
Query: 1149 NEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDE-QVGLPGKGGKAKGKKTQM 1207
EK + +R S S + K+ L + + E E + + + K ++
Sbjct: 833 AEKTKAEHKSRRSSDSKIQKDSLGSKQHGITLQRRSESYSEDKCDMDSTNMDSNLKPEEV 892
Query: 1208 AEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEK--- 1264
+ ++ ++ K++ + K K ++ E EG+ ++ ++ E+
Sbjct: 893 VHKEKRRTKSLLEEKLVLKSKSKTQGKQVKVVETELQEGATKQATTPKPDKEKNTEENDS 952
Query: 1265 KQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKT 1324
+++R+ + K +P+ + + S + SS + + + + + +T T
Sbjct: 953 EKQRKSKVEDKPFEETGVEPVLETASSSAHSTQKD--SSHRAKLPLAKEKYKSDKDSTST 1010
Query: 1325 KFTMDLD----------SDEDFSDFDE-KTDDEDFVPSDASPPKTKTSPKLSNKELKPQ- 1372
+ L S +D DE K+DD+D D+S K + + L K+L +
Sbjct: 1011 RLERKLSDGHKSRSLKHSSKDIKKKDENKSDDKDGKEVDSSHEKARGNSSLMEKKLSRRL 1070
Query: 1373 -KSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTV 1416
++ L + KG L+++ +T P + + P ++T+
Sbjct: 1071 CENRRGSLSQEMAKGEEKLAANTLST--PSGSSLQRPKKSGDMTL 1113
Score = 34.7 bits (78), Expect = 0.73
Identities = 86/442 (19%), Positives = 159/442 (35%), Gaps = 64/442 (14%)
Query: 1095 QKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQE 1154
Q+ + E+ N K +E++ S PT + D +++ D+ + +
Sbjct: 213 QEASAARASTETSNAKTSERASKKLPSQPTTDTSTDKER--TSEDMADKEKSTADSGGEG 270
Query: 1155 LDTL-KRKSPSDLW--KEDLATFIEELEAVEAKEKQDEQVGLPGKGGKAKGKKTQMAEVL 1211
L+T K + SDL E++ + +E + K +Q + + K K T E
Sbjct: 271 LETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQ-----ESSEQKNKSTDKGEKK 325
Query: 1212 PSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKKQKREPG 1271
P K E +K+ K+K + + ED +K K E
Sbjct: 326 PDSNE-----------KGERKKEKKEKTEKKFDHSKKSED-----------TQKVKDEKQ 363
Query: 1272 TKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLD 1331
K K+ +L K K ++ D S +S+ D T T+
Sbjct: 364 AKEKEVESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVD------------GLTDITVSSV 411
Query: 1332 SDEDFSDFDEKTDDEDFVPSDASPPKTKTS---PKLSNKELKPQKSVVSDLEADDVKGSV 1388
D S F+E T +E+ V SD+ TS K + K Q S S+ + V+ +
Sbjct: 412 HTSDLSSFEEDT-EEEVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAY 470
Query: 1389 PLSSSPPATHFPD-ETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPAL 1447
+ ++ D + E+T ++++ +K + + +++ K K +
Sbjct: 471 VHKPYLYSKYYSDSDDELTVEQRRQSIAKEKEERLLRRQINREKLEEKRKQKAEKTKSSK 530
Query: 1448 NSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIV--SKAVTSKKSKGESDDFHMDFDSA 1505
G + + + + +P + + E+ V K SKK K +S
Sbjct: 531 TKGQGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDS---------- 580
Query: 1506 VAPRAKSVRAKKPIKYLEESDE 1527
R +KK +Y E+S E
Sbjct: 581 ---RNVEENSKKKQQYEEDSKE 599
>gi|156104891 general transcription factor IIF, polypeptide 1, 74kDa
[Homo sapiens]
Length = 517
Score = 46.2 bits (108), Expect = 2e-04
Identities = 84/338 (24%), Positives = 127/338 (37%), Gaps = 52/338 (15%)
Query: 1148 RNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKAKGKKTQM 1207
++E E+E + R+ S+L DL +E + +A + E+ G+ KAK K
Sbjct: 187 QDEDEEEKEKRGRRKASELRIHDLEDDLEM--SSDASDASGEE---GGRVPKAKKKA--- 238
Query: 1208 AEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGSPQED--GVELEGLKQRLEKK 1265
P +G R +KK KK +E E S D G E++ +
Sbjct: 239 ----PLAKGGR-------------KKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSS 281
Query: 1266 QKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPP----RETEPRRAA 1321
Q+ EP +K K ++ P E SS+ES + PP E E ++A
Sbjct: 282 QE-EPESKAKAPQ----------QEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAP 330
Query: 1322 TKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLEA 1381
T + DS E+ SD E++D + S K KT PK K S
Sbjct: 331 TPQEKKRRKDSSEE-SDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGT 389
Query: 1382 DDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGT 1441
+G S+ A ++ + + +P T +S S ST P
Sbjct: 390 PSAEGGSTSSTLRAAASKLEQGKRVSEMPAAKRLRLDTGPQSLSGKST------PQPPSG 443
Query: 1442 KRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFE 1479
K P NSG Q + A + RKP T+ D F+
Sbjct: 444 KTTP--NSGDVQVTEDA-VRRYLTRKPMTTKDLLKKFQ 478
Score = 36.2 bits (82), Expect = 0.25
Identities = 48/210 (22%), Positives = 83/210 (39%), Gaps = 23/210 (10%)
Query: 1286 KKGKKRNPWSDSESDRSSDES-NFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTD 1344
++ K N +S + R D+ + D +E RR A++ + DL+ D + S
Sbjct: 166 RRNKVLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIH-DLEDDLEMSSDASDAS 224
Query: 1345 DEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLEA------DDVKGSVPLSSSPPATH 1398
E+ PK K L+ K +K SD EA D +G S ++
Sbjct: 225 GEE----GGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSS 280
Query: 1399 FPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNSGVSQKPDPA 1458
+E E P++ K +S SS + K P+ K + ++ A
Sbjct: 281 SQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKP---PEEDKEE--------EEEKKA 329
Query: 1459 KTKNRRKRKPSTSDDSDSNFEKIVSKAVTS 1488
T +KR+ +S++SDS+ E + +S
Sbjct: 330 PTPQEKKRRKDSSEESDSSEESDIDSEASS 359
>gi|125656165 THO complex 2 [Homo sapiens]
Length = 1593
Score = 45.8 bits (107), Expect = 3e-04
Identities = 72/377 (19%), Positives = 136/377 (36%), Gaps = 26/377 (6%)
Query: 1138 KEKKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDE-------- 1189
K ++ C ++ + T K S + + ++E + + KEK+ E
Sbjct: 1229 KSRERSQCGVKAVNKASSTTPKGNSSNGNSGSNSNKAVKENDKEKGKEKEKEKKEKTPAT 1288
Query: 1190 --QVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNENTEGS 1247
+ + GK GK K K+ + P+ + R T E +++K+ +K K E +
Sbjct: 1289 TPEARVLGKDGKEKPKEER-----PNKDEKA---RETKERTPKSDKEKEKFKKEEKAKDE 1340
Query: 1248 PQEDGVELEGLKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSSDESN 1307
+ V K E+++++EP + + K KG ++ P S S S
Sbjct: 1341 KFKTTVPNAESKSTQEREREKEPSRERDIAKEMKSKENVKGGEKTPVSGS---LKSPVPR 1397
Query: 1308 FDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPK-LSN 1366
D+P E E +R T + S S + K + PP +K+ + +
Sbjct: 1398 SDIPEPEREQKRRKIDTHPSPSHSSTVKDSLIELKESSAKLYINHTPPPLSKSKEREMDK 1457
Query: 1367 KELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSS 1426
K+L + + E D K H ++ E+ + K+ T S+
Sbjct: 1458 KDLDKSRERSREREKKDEKDR----KERKRDHSNNDREVPPDLTKRRKEENGTMGVSKHK 1513
Query: 1427 TSTTGAKKRAAPKGTKRDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAV 1486
+ + K +++ + +SG + D K++ K +S + EKI K
Sbjct: 1514 SESPCESPYPNEKDKEKNKSKSSGKEKGSDSFKSEKMDKISSGGKKESRHDKEKIEKKEK 1573
Query: 1487 TSKKSKGESDDFHMDFD 1503
E H D
Sbjct: 1574 RDSSGGKEEKKHHKSSD 1590
>gi|33356174 pinin, desmosome associated protein [Homo sapiens]
Length = 717
Score = 45.8 bits (107), Expect = 3e-04
Identities = 86/448 (19%), Positives = 183/448 (40%), Gaps = 34/448 (7%)
Query: 1091 KEAQQKVPDEEENEESDNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNE 1150
++ Q V +EE+ E + K ++ + + ++G N D+ + +E++ E+ + ++
Sbjct: 292 EKEHQVVRNEEQKAEQEEGKVAQREEELEETGNQHN---DVEIEEAGEEEEKEIAIVHSD 348
Query: 1151 KEQELDTLKRKSPSDLWKEDLATFIEELEAVEAKEKQDEQVG-LPGKGGKAKGKKTQMA- 1208
E+E + ++K ++ E EE E E++++QD Q + + K +A
Sbjct: 349 AEKEQEEEEQKQEMEVKME------EETEVRESEKQQDSQPEEVMDVLEMVENVKHVIAD 402
Query: 1209 -EVLPSPRGQRVIPRITIEMKAEAEKKNKKKIK--NENTEGSPQEDGVELEGLKQRLEKK 1265
EV+ + R + V P E E E + + +I+ E SP ++ V +++ E+K
Sbjct: 403 QEVMETNRVESVEPSEN-EASKELEPEMEFEIEPDKECKSLSPGKENVSALDMEKESEEK 461
Query: 1266 QKRE--PGTKTKKQTTLAFKP-IKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAAT 1322
+++E P + Q +P ++ + P S+ ++ + V +P T
Sbjct: 462 EEKESEPQPEPVAQPQPQSQPQLQLQSQSQPVLQSQPPSQPEDLSLAV----LQPTPQVT 517
Query: 1323 KTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLEAD 1382
+ + + L +DF K + P P++K+ K ++ ++ S +
Sbjct: 518 QEQGHL-LPERKDFPVESVKLTEVPVEPVLTVHPESKSKTKTRSRSRGRARNKTSKSRSR 576
Query: 1383 DVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTK 1442
S SSS ++ + ++ + + S SS+ST+G+ R + T
Sbjct: 577 SSSSSSSSSSSTSSSSGSSSSSGSS----------SSRSSSSSSSSTSGSSSRDSSSSTS 626
Query: 1443 RDPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESD-DFHMD 1501
S + K+RR D S SK +S+ +KG D + D
Sbjct: 627 SSSESRSRSRGRGHNRDRKHRRSVDRKRRDTSGLERSHKSSKGGSSRDTKGSKDKNSRSD 686
Query: 1502 FDSAVAPRAKSVRAKKPIKYLEESDEDD 1529
+++ ++S + + +SD D
Sbjct: 687 RKRSISESSRSGKRSSRSERDRKSDRKD 714
Score = 34.7 bits (78), Expect = 0.73
Identities = 75/382 (19%), Positives = 147/382 (38%), Gaps = 38/382 (9%)
Query: 1084 SDPVKAWKEAQQKVPDEEENEESDNEKETEK-SDSVTDSGPTFNYLLDMPLWYLTKEKKD 1142
SD K +E +QK E + EE +E+EK DS + +++ + ++
Sbjct: 347 SDAEKEQEEEEQKQEMEVKMEEETEVRESEKQQDSQPEEVMDVLEMVENVKHVIADQEVM 406
Query: 1143 ELCRLRNEKEQELDTLKRKSPS--------------DLWKEDLATFIEELEAVEAKEKQD 1188
E R+ + + E + K P KE+++ E E+ E +EK+
Sbjct: 407 ETNRVESVEPSENEASKELEPEMEFEIEPDKECKSLSPGKENVSALDMEKESEEKEEKES 466
Query: 1189 EQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVI---PRITIEMKAEAEKKNKKKIKNENTE 1245
E P A+ + ++ + Q V+ P E + A + ++ E
Sbjct: 467 E----PQPEPVAQPQPQSQPQLQLQSQSQPVLQSQPPSQPEDLSLAVLQPTPQVTQEQGH 522
Query: 1246 GSPQEDGVELEGLKQR---LEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRS 1302
P+ +E +K +E P +K+K +T + +G+ RN S S S RS
Sbjct: 523 LLPERKDFPVESVKLTEVPVEPVLTVHPESKSKTKT----RSRSRGRARNKTSKSRS-RS 577
Query: 1303 SDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFSDFDEKTDDEDFVPSDASPPKTKTSP 1362
S S+ + +++ + S S + D S +S ++++
Sbjct: 578 SSSSSSSSSSTSSSSGSSSSSGSSSSRSSSSSSSSTSGSSSRDSSSSTSSSSESRSRSRG 637
Query: 1363 KLSNKELKPQKSVVSDLEADDVKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAK 1422
+ N++ K ++SV D + D G L S ++ + K + + +K +
Sbjct: 638 RGHNRDRKHRRSV--DRKRRDTSG---LERSHKSSKGGSSRDTKGSKDKNSRSDRK---R 689
Query: 1423 SQSSTSTTGAKKRAAPKGTKRD 1444
S S +S +G + + + K D
Sbjct: 690 SISESSRSGKRSSRSERDRKSD 711
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 45.8 bits (107), Expect = 3e-04
Identities = 65/276 (23%), Positives = 112/276 (40%), Gaps = 51/276 (18%)
Query: 1079 QRGYDSDPVKAWKEAQQKVPDEE----ENEESDNEKETEKSDSVTDSGPTFNYL------ 1128
Q+ + + +K +E + K +EE E E +KE E+ + + G
Sbjct: 358 QKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARA 417
Query: 1129 -LDMPLWYLTKE-----KKDELCRLRNEKEQELDTLKRKSPSDLWKEDLATFIEELEAVE 1182
+ L L + KD L + R E D ++K P L ++++ +E AVE
Sbjct: 418 RAEATLKLLQAQGVEVPSKDSLPKKRPIYE---DKKRKKIPQQLESKEVSESMELCAAVE 474
Query: 1183 A------------------KEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRIT 1224
+E+ E GL A ++T+ E G +V
Sbjct: 475 VMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVE------GNKV----H 524
Query: 1225 IEMKAEAEKKNKKKIKNENTEGSPQEDGVELEGLKQRLEKKQKREPGTKTKKQ-TTLAFK 1283
IE+K E++ +++ + E E S +E+ E EG + E ++ E + K TL K
Sbjct: 525 IEVKENPEEEEEEEEEEEEDEESEEEE--EEEGESEGSEGDEEDEKVSDEKDSGKTLDKK 582
Query: 1284 PIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRR 1319
P K+ + + DS+ DR+ +E +D R E RR
Sbjct: 583 PSKEMSSDSEY-DSDDDRTKEERAYDKAKRRIEKRR 617
Score = 44.7 bits (104), Expect = 7e-04
Identities = 97/501 (19%), Positives = 180/501 (35%), Gaps = 70/501 (13%)
Query: 1047 KLNNQARFILEKIDGKIIIENKPKKELIKVLIQRGYDSDPVKAWKEAQQKV-PDEEENEE 1105
K ++ + L K+ K +E K + + QR ++ + VK+ V P EE E
Sbjct: 241 KKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAE 300
Query: 1106 S------DNEKETEKSDSVTDSGPTFNYLLDMPLWYLTKEKKDELCRLRNEKEQELDTLK 1159
+ DNE + +K D K+KK E + EKE+E K
Sbjct: 301 TPTAAEDDNEGDKKKKDK--------------------KKKKGE----KEEKEKE----K 332
Query: 1160 RKSPSDLWKEDLATFIEELEAVEAKEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRV 1219
+K PS + + + +L+ E ++K++E+ + ++ E+ + +
Sbjct: 333 KKGPSKATVKAMQEALAKLKEEEERQKREEEERI-----------KRLEELEAKRKEEER 381
Query: 1220 IPRITIEMKAEAEKKNKKKIKNEN--TEGSPQEDGVELEGLKQRLEKKQKREPGTKTKKQ 1277
+ + E K + EK+ K+++K E S +E E + L+ + P K
Sbjct: 382 LEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVP----SKD 437
Query: 1278 TTLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFTMDLDSDEDFS 1337
+ +PI + KKR + ES E + K + ++ +E+
Sbjct: 438 SLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEED 497
Query: 1338 DFDEKTDDEDFVPSDASPPK---------TKTSPKLSNKELKPQKSVVSDLEADDVKGSV 1388
D DD + + SD K K +P+ +E + ++ E ++ +G
Sbjct: 498 TEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGES 557
Query: 1389 PLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALN 1448
S +E E + T+ K +K SS S + + D A
Sbjct: 558 EGSEG------DEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKR 611
Query: 1449 SGVSQKPDPAKTKNRRK-RKP--STSDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSA 1505
++ + +K N K R P D+ KI+ K + GE+ +
Sbjct: 612 RIEKRRLEHSKNVNTEKLRAPIICVLGHVDTGKTKILDKLRHTHVQDGEAGGITQQIGAT 671
Query: 1506 VAPRAKSVRAKKPIKYLEESD 1526
P K IK + +
Sbjct: 672 NVPLEAINEQTKMIKNFDREN 692
Score = 40.8 bits (94), Expect = 0.010
Identities = 65/325 (20%), Positives = 125/325 (38%), Gaps = 41/325 (12%)
Query: 1232 EKKNKKK-------IKNENTEGSPQEDGVE----------LEGLKQRLEKKQKREPGTKT 1274
+KK KKK I E E S + G++ E ++ K K++ G K
Sbjct: 44 KKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKG 103
Query: 1275 KKQT-------TLAFKPIKKGKKRNPWSDSESDRSSDESNFDVPPRETEPRRAATKTKFT 1327
KKQ+ L K K K P + S S D+ +F+ P++ + + + K+
Sbjct: 104 KKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSG-SDDDDDFNKLPKKAKGKAQKSNKKWD 162
Query: 1328 MDLDSDEDFSDFDEK----TDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLEADD 1383
+ +++ E+ + E SD K K N++ KP ++ S E DD
Sbjct: 163 GSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKK--NQKNKPGPNIESGNEDDD 220
Query: 1384 VKGSVPLSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKR 1443
+ + A E + + ++ ++K K + T K+ +
Sbjct: 221 ASFKIKTVAQKKAEKKERERKKRD---EEKAKLRKLKEKEELETGKKDQSKQKESQRKFE 277
Query: 1444 DPALNSGVSQKPDPAKTKNRRKRKPSTSDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFD 1503
+ + S V+ + P+ ++D + +K K KK KGE ++ + +
Sbjct: 278 EETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDK----KKKKGEKEE--KEKE 331
Query: 1504 SAVAPRAKSVRA-KKPIKYLEESDE 1527
P +V+A ++ + L+E +E
Sbjct: 332 KKKGPSKATVKAMQEALAKLKEEEE 356
Score = 39.3 bits (90), Expect = 0.030
Identities = 60/323 (18%), Positives = 121/323 (37%), Gaps = 48/323 (14%)
Query: 1072 ELIKVLIQRGYDSDPVKAWKEAQQKVPDEEENEE---SDNEKETEKSDSVTDSGPTFNYL 1128
+++K L + ++ +KA +E P E EE D +K+ +K + L
Sbjct: 57 DILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEEL 116
Query: 1129 LDMPLWYLTKEKKDELCRLR----NEKEQELDTLKRKSPSDLWKEDLA-TFIEELEAVEA 1183
D +K KK ++ ++ + + + L +K+ K + EE E
Sbjct: 117 EDKD----SKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSK 172
Query: 1184 KEKQDEQVGLPGKGGKAKGKKTQMAEVLPSPRGQRVIPRITIEMKAEAEKKNKKKIKNEN 1243
K K+ ++ G+ G + E L S +GQ KKN+K N
Sbjct: 173 KIKERSRINSSGESGD------ESDEFLQSRKGQ---------------KKNQKNKPGPN 211
Query: 1244 TEGSPQEDGVELEGLKQRLEKKQKREPGTKTKKQTTLAFKPIKKGKKRNPWSDSESDRSS 1303
E ++D + +K +K+E K + + + +K+ ++ +S +
Sbjct: 212 IESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKE 271
Query: 1304 DESNFDVPPRETEPRRAATKTKFTMD---LDSDEDFSDFDEKTDDE---DFVPSDASPPK 1357
+ F+ K+K T+D + + E+ ++ +D+ D D K
Sbjct: 272 SQRKFE---------EETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKK 322
Query: 1358 TKTSPKLSNKELKPQKSVVSDLE 1380
+ K K+ P K+ V ++
Sbjct: 323 GEKEEKEKEKKKGPSKATVKAMQ 345
Score = 36.6 bits (83), Expect = 0.19
Identities = 51/207 (24%), Positives = 80/207 (38%), Gaps = 30/207 (14%)
Query: 1331 DSDEDFSDFDEKTDDEDFVPSDASPPKTKTSPKLSNKELKPQKSVVSDLEADDV-KGSVP 1389
DS +D D D + + A K + K K+ K +K D + DD+ K
Sbjct: 11 DSTKDDIDLDALAAEIE----GAGAAKEQEPQKSKGKKKKEKKK--QDFDEDDILKELEE 64
Query: 1390 LSSSPPATHFPDETEITNPVPKKNVTVKKTAAKSQSSTSTTGAKKRAAPKGTKRDPALNS 1449
LS ET V VK T + TS KK+ KG K+ + +
Sbjct: 65 LSLEAQGIKADRET----------VAVKPTENNEEEFTSKD--KKKKGQKGKKQ--SFDD 110
Query: 1450 GVSQKPDPAKTKNRRKRKPS----TSDDSDSNFEKIVSKAVTSKKSKGESDDFHMDFDSA 1505
S++ + +K+++ KP + D D +F K+ KA K K + + D
Sbjct: 111 NDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKA----KGKAQKSNKKWDGSEE 166
Query: 1506 VAPRAKSVRAKKPIKYLEES-DEDDLF 1531
+K ++ + I ES DE D F
Sbjct: 167 DEDNSKKIKERSRINSSGESGDESDEF 193
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.132 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 58,494,655
Number of Sequences: 37866
Number of extensions: 2774048
Number of successful extensions: 13664
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 43
Number of HSP's successfully gapped in prelim test: 586
Number of HSP's that attempted gapping in prelim test: 11002
Number of HSP's gapped (non-prelim): 2473
length of query: 1531
length of database: 18,247,518
effective HSP length: 115
effective length of query: 1416
effective length of database: 13,892,928
effective search space: 19672386048
effective search space used: 19672386048
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.