Guide to the Human Genome
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Name: TOP2A Sequence: fasta or formatted (1531aa) NCBI GI: 19913406
Description:

DNA topoisomerase II, alpha isozyme

Referenced in:

Replication Proteins

Composition:

amino acid map
 Amino acid        Percentage    Count  Longest homopolymer
 A alanine             4.7         72           2
 C cysteine            0.8         13           1
 D aspartate           6.7        103           3
 E glutamate           8.0        123           3
 F phenylalanine       3.8         58           2
 G glycine             5.5         84           2
 H histidine           1.6         24           2
 I isoleucine          5.5         84           3
 K lysine             11.7        179           3
 L leucine             8.0        123           2
 M methionine          2.5         39           2
 N asparagine          5.2         79           2
 P proline             4.8         74           2
 Q glutamine           3.7         56           2
 R arginine            4.4         67           2
 S serine              6.9        105           3
 T threonine           5.9         91           3
 V valine              6.3         96           2
 W tryptophan          1.2         18           1
 Y tyrosine            2.8         43           2
Comparative genomics:

Search single species RefSeq proteins at NCBI
   H. sapiens
   M. musculus
   D. rerio
   C. intestinalis
   S. purpuratus
   D. melanogaster
   C. elegans
   A. thaliana
   S. cerevisiae
   E. coli W3110
   A. pernix K1

Search summary

comparative genomics plot

   Figure data

Additional searches of
RefSeq proteins at NCBI

   All
   Eukaryotes
   Bacteria
   Archaea
   Viruses
   Primates
   Mammals
   Vertebrates

Related human proteins:
Protein          Relative score         Description

Self-match            1.000   DNA topoisomerase II, alpha isozyme 
TOP2B                 0.685   DNA topoisomerase II, beta isozyme 
CYLC1                 0.016   cylicin, basic protein of sperm head cytoskeleton 1...
NOLC1                 0.015   nucleolar and coiled-body phosphoprotein 1 
NEFH                  0.012   neurofilament, heavy polypeptide 200kDa 
TRDN                  0.011   triadin 
SETD1A                0.010   SET domain containing 1A 
ATRX                  0.010   transcriptional regulator ATRX isoform 2 
ATRX                  0.010   transcriptional regulator ATRX isoform 1 
RBBP6                 0.009   retinoblastoma-binding protein 6 isoform 2 
RBBP6                 0.009   retinoblastoma-binding protein 6 isoform 1 
IWS1                  0.009   IWS1 homolog 
NCL                   0.009   nucleolin 
CTR9                  0.008   SH2 domain binding protein 1 
ARID4A                0.008   retinoblastoma-binding protein 1 isoform III 
ARID4A                0.008   retinoblastoma-binding protein 1 isoform II 
ARID4A                0.008   retinoblastoma-binding protein 1 isoform I 
CYLC2                 0.008   cylicin 2 
DSPP                  0.008   dentin sialophosphoprotein preproprotein 
MLLT1                 0.008   myeloid/lymphoid or mixed-lineage leukemia (trithora...
UNC13A                0.008   unc-13 homolog A 
PCLO                  0.007   piccolo isoform 2 
PCLO                  0.007   piccolo isoform 1 
NEFM                  0.007   neurofilament, medium polypeptide 150kDa isoform 1 ...
NEFM                  0.007   neurofilament, medium polypeptide 150kDa isoform 2 ...
BOD1L                 0.007   biorientation of chromosomes in cell division 1-like...
GTF2F1                0.007   general transcription factor IIF, polypeptide 1, 74...
THOC2                 0.007   THO complex 2 
PNN                   0.007   pinin, desmosome associated protein 
EIF5B                 0.007   eukaryotic translation initiation factor 5B 
Human BLASTP results (used to prepare the table)

Gene descriptions are from NCBI RefSeq. Search results were obtained with NCBI BLAST and RefSeq entries. When identical proteins are present, the self-match may not be listed first in BLASTP output. In such cases, the table above has been reordered to place it first.

See About the Figures for the scoring system used in the figure above right. The same scoring system was used in the table of BLASTP results.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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