Search of human proteins with 19882209

Search of human proteins with 19882209

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|19882209 interleukin 1 receptor accessory protein isoform 2
[Homo sapiens]
         (356 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|19882209 interleukin 1 receptor accessory protein isoform 2 [...   747   0.0  
gi|4504661 interleukin 1 receptor accessory protein isoform 1 [H...   733   0.0  
gi|11225607 interleukin 1 receptor accessory protein-like 2 [Hom...   160   2e-39
gi|7657232 interleukin 1 receptor accessory protein-like 1 precu...   154   1e-37
gi|27894334 interleukin 1 receptor, type II precursor [Homo sapi...    92   9e-19
gi|4758598 interleukin 1 receptor, type II precursor [Homo sapiens]    92   9e-19
gi|4504659 interleukin 1 receptor, type I precursor [Homo sapiens]     83   4e-16
gi|27894328 interleukin 1 receptor-like 1 isoform 2 precursor [H...    80   4e-15
gi|27894324 interleukin 1 receptor-like 1 isoform 1 precursor [H...    80   4e-15
gi|4504655 interleukin 18 receptor 1 precursor [Homo sapiens]          70   4e-12
gi|4504657 interleukin 18 receptor accessory protein precursor [...    68   1e-11
gi|28416902 interleukin 1 receptor-like 2 precursor [Homo sapiens]     66   5e-11
gi|148886752 immunoglobulin superfamily, member 9B [Homo sapiens]      43   4e-04
gi|118572606 hemicentin 1 [Homo sapiens]                               42   8e-04
gi|110349719 titin isoform N2-A [Homo sapiens]                         40   0.003
gi|28373126 contactin 4 isoform c precursor [Homo sapiens]             40   0.004
gi|28373122 contactin 4 isoform a precursor [Homo sapiens]             40   0.004
gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]                    39   0.007
gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]                    39   0.007
gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]                    39   0.007
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo...    39   0.009
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor...    39   0.009
gi|122937205 carcinoembryonic antigen-related cell adhesion mole...    35   0.10 
gi|98986445 carcinoembryonic antigen-related cell adhesion molec...    35   0.13 
gi|75709184 contactin 3 [Homo sapiens]                                 35   0.13 
gi|7657361 contactin 6 [Homo sapiens]                                  35   0.13 
gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42...    34   0.23 
gi|209977117 unc-5 homolog D [Homo sapiens]                            34   0.23 
gi|11321597 kinase insert domain receptor precursor [Homo sapiens]     33   0.30 
gi|119220552 sidekick 1 [Homo sapiens]                                 33   0.30 

>gi|19882209 interleukin 1 receptor accessory protein isoform 2
           [Homo sapiens]
          Length = 356

 Score =  747 bits (1929), Expect = 0.0
 Identities = 356/356 (100%), Positives = 356/356 (100%)

Query: 1   MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST 60
           MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST
Sbjct: 1   MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST 60

Query: 61  AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT 120
           AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT
Sbjct: 61  AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT 120

Query: 121 YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG 180
           YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG
Sbjct: 121 YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG 180

Query: 181 CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA 240
           CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA
Sbjct: 181 CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA 240

Query: 241 VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE 300
           VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE
Sbjct: 241 VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE 300

Query: 301 SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKGNRCGQ 356
           SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKGNRCGQ
Sbjct: 301 SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQKGNRCGQ 356


>gi|4504661 interleukin 1 receptor accessory protein isoform 1 [Homo
           sapiens]
          Length = 570

 Score =  733 bits (1892), Expect = 0.0
 Identities = 350/350 (100%), Positives = 350/350 (100%)

Query: 1   MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST 60
           MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST
Sbjct: 1   MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST 60

Query: 61  AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT 120
           AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT
Sbjct: 61  AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT 120

Query: 121 YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG 180
           YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG
Sbjct: 121 YCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMG 180

Query: 181 CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA 240
           CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA
Sbjct: 181 CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA 240

Query: 241 VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE 300
           VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE
Sbjct: 241 VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE 300

Query: 301 SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQK 350
           SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQK
Sbjct: 301 SISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQK 350


>gi|11225607 interleukin 1 receptor accessory protein-like 2 [Homo
           sapiens]
          Length = 686

 Score =  160 bits (404), Expect = 2e-39
 Identities = 108/357 (30%), Positives = 172/357 (48%), Gaps = 21/357 (5%)

Query: 1   MTLLWC-VVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYS 59
           + L+ C VVS     + + ++ + C DW +D ++       EP R+KC LF  +++ NYS
Sbjct: 7   LALVVCSVVSTNLKMVSKRNSVDGCIDWSVD-LKTYMALAGEPVRVKCALFYSYIRTNYS 65

Query: 60  TAHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNT 119
           TA S GL L+WY  +   DLEEPI F   E R+SKE+D +WF      D+G YTC+LRN+
Sbjct: 66  TAQSTGLRLMWY--KNKGDLEEPIIFS--EVRMSKEEDSIWFHSAEAQDSGFYTCVLRNS 121

Query: 120 TYCSKVAFPLEVVQKDS--CFNSPMKLPVHKLYIEYG----IQRITCPNVDGYFPSSVKP 173
           TYC KV+  L V + +S  C+NS ++      Y+E       + I+CP++D +  S  +P
Sbjct: 122 TYCMKVSMSLTVAENESGLCYNSRIR------YLEKSEVTKRKEISCPDMDDFKKSDQEP 175

Query: 174 TITWYMGCYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKV 233
            + WY  C      + +I +G  L        + GNYTC + Y   G+    T  L V  
Sbjct: 176 DVVWYKECKPKMWRSIIIQKGNALLIQEVQEEDGGNYTCELKY--EGKLVRRTTELKVTA 233

Query: 234 VGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDIT 293
           + + K    P+    N   V + + G+ L IPC  +F F  +S   ++W    K  +++ 
Sbjct: 234 LLTDK-PPKPLFPMENQPSVIDVQLGKPLNIPCKAFFGFSGESGPMIYWMKGEKFIEELA 292

Query: 294 IDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQK 350
             +   E         E   ++  I     E    +Y CH  +  G    +  +++K
Sbjct: 293 GHIREGEIRLLKEHLGEKEVELALIFDSVVEADLANYTCHVENRNGRKHASVLLRKK 349


>gi|7657232 interleukin 1 receptor accessory protein-like 1
           precursor [Homo sapiens]
          Length = 696

 Score =  154 bits (389), Expect = 1e-37
 Identities = 97/300 (32%), Positives = 154/300 (51%), Gaps = 22/300 (7%)

Query: 1   MTLLWCVVSLYFYGILQSDASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYST 60
           + LL+   +     + +  +++ C DW +D +++ QV   EP RIKC LF  +++ NYS 
Sbjct: 8   LILLYATFTQSLKVVTKRGSADGCTDWSID-IKKYQVLVGEPVRIKCALFYGYIRTNYSL 66

Query: 61  AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT 120
           A SAGL+L+WY +    D EEPI F    +R+SKE+D +WFRPTLL D+G Y C++RN+T
Sbjct: 67  AQSAGLSLMWYKSSGPGDFEEPIAF--DGSRMSKEEDSIWFRPTLLQDSGLYACVIRNST 124

Query: 121 YCSKVAFPLEVVQKDS--CFNSPMKLPVHKLYIEYG----IQRITCPNVDGYFPSSVKPT 174
           YC KV+  L V + D+  C+NS MK      Y E       + I+C +++ +   + +P 
Sbjct: 125 YCMKVSISLTVGENDTGLCYNSKMK------YFEKAELSKSKEISCRDIEDFLLPTREPE 178

Query: 175 ITWYMGCYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVV 234
           I WY  C       +++ +   L        + GNYTC + Y   G     T  LTV   
Sbjct: 179 ILWYKECRTKTWRPSIVFKRDTLLIREVREDDIGNYTCELKY--GGFVVRRTTELTVT-- 234

Query: 235 GSPKNAVPPVIHSPNDH--VVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDI 292
            +P    PP +  P +    + E + G+   + C  +F +  D    ++W    K  +D+
Sbjct: 235 -APLTDKPPKLLYPMESKLTIQETQLGDSANLTCRAFFGYSGDVSPLIYWMKGEKFIEDL 293


>gi|27894334 interleukin 1 receptor, type II precursor [Homo
           sapiens]
          Length = 398

 Score = 91.7 bits (226), Expect = 9e-19
 Identities = 73/318 (22%), Positives = 127/318 (39%), Gaps = 20/318 (6%)

Query: 20  ASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDL 79
           A+  C   G    R+ ++ E EP  ++CP   ++L  + S      + L W+     R +
Sbjct: 24  AARSCRFRGRHYKREFRL-EGEPVALRCPQVPYWLWASVSPR----INLTWHKNDSARTV 78

Query: 80  EEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFN 139
                    E R+  +   LW  P L  D+G Y C  RN +YC K++  L V +    F 
Sbjct: 79  PGE-----EETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFL 133

Query: 140 SPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPEGMNLSF 199
             +  P        G+  + CP++  +        I WY     +   N         + 
Sbjct: 134 PFISYPQILTLSTSGV--LVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTH 191

Query: 200 LI---ALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEK 256
           L+     + + G Y CV+T+   G+ +++TR++ +++    +  + PVI SP   +    
Sbjct: 192 LLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETI-PVIISPLKTI--SA 248

Query: 257 EPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTE-DETRTQI 315
             G  L IPC V+          +WWT +    +       + E      +E +E   ++
Sbjct: 249 SLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPRQEYSENNENYIEV 308

Query: 316 -LSIKKVTSEDLKRSYVC 332
            L    VT EDL   + C
Sbjct: 309 PLIFDPVTREDLHMDFKC 326


>gi|4758598 interleukin 1 receptor, type II precursor [Homo sapiens]
          Length = 398

 Score = 91.7 bits (226), Expect = 9e-19
 Identities = 73/318 (22%), Positives = 127/318 (39%), Gaps = 20/318 (6%)

Query: 20  ASERCDDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDL 79
           A+  C   G    R+ ++ E EP  ++CP   ++L  + S      + L W+     R +
Sbjct: 24  AARSCRFRGRHYKREFRL-EGEPVALRCPQVPYWLWASVSPR----INLTWHKNDSARTV 78

Query: 80  EEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFN 139
                    E R+  +   LW  P L  D+G Y C  RN +YC K++  L V +    F 
Sbjct: 79  PGE-----EETRMWAQDGALWLLPALQEDSGTYVCTTRNASYCDKMSIELRVFENTDAFL 133

Query: 140 SPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPEGMNLSF 199
             +  P        G+  + CP++  +        I WY     +   N         + 
Sbjct: 134 PFISYPQILTLSTSGV--LVCPDLSEFTRDKTDVKIQWYKDSLLLDKDNEKFLSVRGTTH 191

Query: 200 LI---ALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEK 256
           L+     + + G Y CV+T+   G+ +++TR++ +++    +  + PVI SP   +    
Sbjct: 192 LLVHDVALEDAGYYRCVLTFAHEGQQYNITRSIELRIKKKKEETI-PVIISPLKTI--SA 248

Query: 257 EPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTE-DETRTQI 315
             G  L IPC V+          +WWT +    +       + E      +E +E   ++
Sbjct: 249 SLGSRLTIPCKVFLGTGTPLTTMLWWTANDTHIESAYPGGRVTEGPRQEYSENNENYIEV 308

Query: 316 -LSIKKVTSEDLKRSYVC 332
            L    VT EDL   + C
Sbjct: 309 PLIFDPVTREDLHMDFKC 326


>gi|4504659 interleukin 1 receptor, type I precursor [Homo sapiens]
          Length = 569

 Score = 82.8 bits (203), Expect = 4e-16
 Identities = 65/284 (22%), Positives = 127/284 (44%), Gaps = 29/284 (10%)

Query: 67  TLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVA 126
           T+ WY      D + P++     +RI + K+ LWF P  + D+G+Y C++RN++YC ++ 
Sbjct: 54  TITWY----KDDSKTPVSTE-QASRIHQHKEKLWFVPAKVEDSGHYYCVVRNSSYCLRIK 108

Query: 127 FPLEVVQKDS--CFNS----PMKLPVHKLYIEYGIQRITCPNVDGY-FPSSVKPTITWYM 179
              + V+ +   C+N+      KLPV       G   + CP ++ +   ++  P + WY 
Sbjct: 109 ISAKFVENEPNLCYNAQAIFKQKLPV------AGDGGLVCPYMEFFKNENNELPKLQWYK 162

Query: 180 GCYKIQNFNNVIPEGMNLSFLIALIS--NNGNYTCVVTYPENGRTFHLTRTLTVKVVGSP 237
            C K    +N+   G+    ++  ++  + GNYTC  +Y   G+ + +TR +    +   
Sbjct: 163 DC-KPLLLDNIHFSGVKDRLIVMNVAEKHRGNYTCHASYTYLGKQYPITRVIEFITLEEN 221

Query: 238 KNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGK--KPDDITID 295
           K   P ++   N+    E + G ++ + C V         +  +W  +G     DD  + 
Sbjct: 222 KPTRPVIVSPANE--TMEVDLGSQIQLICNVTGQL----SDIAYWKWNGSVIDEDDPVLG 275

Query: 296 VTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKG 339
                  + +     T   +L+I ++ S   K  + C A++  G
Sbjct: 276 EDYYSVENPANKRRSTLITVLNISEIESRFYKHPFTCFAKNTHG 319


>gi|27894328 interleukin 1 receptor-like 1 isoform 2 precursor [Homo
           sapiens]
          Length = 328

 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 72/292 (24%), Positives = 124/292 (42%), Gaps = 23/292 (7%)

Query: 67  TLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVA 126
           T+ WY+++ ++ +  P   R   NR+     +L F P  + D+G YTC++R+ T+     
Sbjct: 45  TVDWYYSQTNKSI--PTQER---NRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGY 99

Query: 127 FPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQN 186
             + + +K S  N P  L    +       +I CP +D Y   +    + W+  C  +Q 
Sbjct: 100 ANVTIYKKQSDCNVPDYLMYSTVSGSEKNSKIYCPTIDLY---NWTAPLEWFKNCQALQG 156

Query: 187 FNNVIPEGMNLSFLI---ALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPP 243
                    + SFL+    +  + G+YTC   + ENG  + +T T +  V      ++ P
Sbjct: 157 SRY----RAHKSFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFTVKDEQGFSLFP 212

Query: 244 VIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDD-----ITIDVTI 298
           VI +P  + + E E G+   + C+  F         V W ++G K  D     I  +   
Sbjct: 213 VIGAPAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQ 272

Query: 299 NESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQK 350
           N+S S+          +L I  V  EDL   Y C A +  G      ++ +K
Sbjct: 273 NQSFSNGLA---CLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVRLSRK 321


>gi|27894324 interleukin 1 receptor-like 1 isoform 1 precursor [Homo
           sapiens]
          Length = 556

 Score = 79.7 bits (195), Expect = 4e-15
 Identities = 72/292 (24%), Positives = 124/292 (42%), Gaps = 23/292 (7%)

Query: 67  TLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVA 126
           T+ WY+++ ++ +  P   R   NR+     +L F P  + D+G YTC++R+ T+     
Sbjct: 45  TVDWYYSQTNKSI--PTQER---NRVFASGQLLKFLPAAVADSGIYTCIVRSPTFNRTGY 99

Query: 127 FPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQN 186
             + + +K S  N P  L    +       +I CP +D Y   +    + W+  C  +Q 
Sbjct: 100 ANVTIYKKQSDCNVPDYLMYSTVSGSEKNSKIYCPTIDLY---NWTAPLEWFKNCQALQG 156

Query: 187 FNNVIPEGMNLSFLI---ALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPP 243
                    + SFL+    +  + G+YTC   + ENG  + +T T +  V      ++ P
Sbjct: 157 SRY----RAHKSFLVIDNVMTEDAGDYTCKFIHNENGANYSVTATRSFTVKDEQGFSLFP 212

Query: 244 VIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDD-----ITIDVTI 298
           VI +P  + + E E G+   + C+  F         V W ++G K  D     I  +   
Sbjct: 213 VIGAPAQNEIKEVEIGKNANLTCSACFGKGTQFLAAVLWQLNGTKITDFGEPRIQQEEGQ 272

Query: 299 NESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQK 350
           N+S S+          +L I  V  EDL   Y C A +  G      ++ +K
Sbjct: 273 NQSFSNGLA---CLDMVLRIADVKEEDLLLQYDCLALNLHGLRRHTVRLSRK 321


>gi|4504655 interleukin 18 receptor 1 precursor [Homo sapiens]
          Length = 541

 Score = 69.7 bits (169), Expect = 4e-12
 Identities = 85/322 (26%), Positives = 136/322 (42%), Gaps = 35/322 (10%)

Query: 35  IQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTL-IWYWTRQDRDLEEPINFRLPENRIS 93
           I V E EP  +K          + S AH    T   WY +   ++  E +N R   +RI+
Sbjct: 28  ITVVEGEPFYLK--------HCSCSLAHEIETTTKSWYKSSGSQEHVE-LNPR-SSSRIA 77

Query: 94  KEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQ--KDSCFNSPMKLPVHKLYI 151
               VL F P  LNDTG+Y   ++N T   K    L V++  K SCF    +    K+  
Sbjct: 78  LHDCVLEFWPVELNDTGSYFFQMKNYTQKWK----LNVIRRNKHSCFTE--RQVTSKIVE 131

Query: 152 EYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPE-GMNLSFLIALISNNGNY 210
                +ITC N   Y+ + V  T + Y  C K+   NN  P    N  F      + G Y
Sbjct: 132 VKKFFQITCEN--SYYQTLVNST-SLYKNCKKLLLENNKNPTIKKNAEF-----EDQGYY 183

Query: 211 TCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYF 270
           +CV     NG+ F++T+T  + +V    N VP ++    +HV  E   G+ + + C    
Sbjct: 184 SCVHFLHHNGKLFNITKTFNITIVEDRSNIVPVLLGPKLNHVAVEL--GKNVRLNC---- 237

Query: 271 SFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSY 330
           S L++  + ++W    +   D  I       I     +    +++L I+ +   +L   Y
Sbjct: 238 SALLNEEDVIYWMFGEENGSDPNIHEEKEMRIMTPEGKWHA-SKVLRIENIGESNLNVLY 296

Query: 331 VCHARSAKGEVAKAAKVKQKGN 352
            C   S  G   K+  + +K +
Sbjct: 297 NCTVASTGGTDTKSFILVRKAD 318


>gi|4504657 interleukin 18 receptor accessory protein precursor
           [Homo sapiens]
          Length = 599

 Score = 67.8 bits (164), Expect = 1e-11
 Identities = 66/291 (22%), Positives = 123/291 (42%), Gaps = 29/291 (9%)

Query: 70  WYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLR------NTTYCS 123
           WY    + D  E I    P   I ++K  L F    +N++G+Y C  +      +   C 
Sbjct: 84  WYQQPSNGDPLEDIRKSYPH--IIQDKCTLHFLTPGVNNSGSYICRPKMIKSPYDVACCV 141

Query: 124 KVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQ-RITCPNVDGYFPSSVKPTITWYMG-- 180
           K+   ++     SC  S      HK  +  G    I+CP++     +   P +TWY    
Sbjct: 142 KMILEVKPQTNASCEYSAS----HKQDLLLGSTGSISCPSLSCQSDAQ-SPAVTWYKNGK 196

Query: 181 CYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNA 240
              ++  N ++ + +          + G Y C  T  +   ++ +   + V+ +      
Sbjct: 197 LLSVERSNRIVVDEV-------YDYHQGTYVCDYTQSDTVSSWTVRAVVQVRTIVGDTKL 249

Query: 241 VPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINE 300
            P ++    D +  E E G+ L I C   F F       + W I   K  D+  +V++ E
Sbjct: 250 KPDILDPVEDTL--EVELGKPLTISCKARFGFERVFNPVIKWYI---KDSDLEWEVSVPE 304

Query: 301 SISHSRT-EDETRTQILSIKKVTSEDLKRSYVCHARSAKGEVAKAAKVKQK 350
           + S   T +DE   + + ++KVT  DL+R +VC  +++ G   ++ ++K+K
Sbjct: 305 AKSIKSTLKDEIIERNIILEKVTQRDLRRKFVCFVQNSIGNTTQSVQLKEK 355


>gi|28416902 interleukin 1 receptor-like 2 precursor [Homo sapiens]
          Length = 575

 Score = 65.9 bits (159), Expect = 5e-11
 Identities = 68/285 (23%), Positives = 126/285 (44%), Gaps = 28/285 (9%)

Query: 63  SAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYC 122
           S  +++ WY        + P++ ++ ++RI +++  + F P    D+G Y C+++    C
Sbjct: 49  SGEVSVTWY----KNSSKIPVS-KIIQSRIHQDETWILFLPMEWGDSGVYQCVIKGRDSC 103

Query: 123 SKVAFPLEVVQKDSCFNSPMKLP----VHKLYIEYG-IQRITCPNVDGYFPSS-VKPTIT 176
            ++   L V +K  C  S   LP     +K  +  G    +TC     +FP S V   I 
Sbjct: 104 HRIHVNLTVFEKHWCDTSIGGLPNLSDEYKQILHLGKDDSLTC---HLHFPKSCVLGPIK 160

Query: 177 WYMGCYKIQNFNNVIPEGMNLSFLIALIS--NNGNYTCVVTYPENGRTFHLTRTLTVKVV 234
           WY  C +I+     +   +    L++ +S  + GNY C      +G+ + +   +TV + 
Sbjct: 161 WYKDCNEIKGERFTV---LETRLLVSNVSAEDRGNYACQAILTHSGKQYEVLNGITVSIT 217

Query: 235 --GSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDI 292
                  +VP +I+ P +H + E + G  L++ C V  +   D+ N   W ++    DD 
Sbjct: 218 ERAGYGGSVPKIIY-PKNHSI-EVQLGTTLIVDCNV--TDTKDNTNLRCWRVNNTLVDDY 273

Query: 293 TID-VTINESISH--SRTEDETRTQILSIKKVTSEDLKRSYVCHA 334
             +   I E +    S  E    T  ++  +V  ED    ++CHA
Sbjct: 274 YDESKRIREGVETHVSFREHNLYTVNITFLEVKMEDYGLPFMCHA 318


>gi|148886752 immunoglobulin superfamily, member 9B [Homo sapiens]
          Length = 1349

 Score = 43.1 bits (100), Expect = 4e-04
 Identities = 61/213 (28%), Positives = 86/213 (40%), Gaps = 31/213 (14%)

Query: 61  AHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTT 120
           A+   LT  WYW  ++   +  +  R+   RI  +  ++ FR     D+G YTC+  N+ 
Sbjct: 254 AYPGNLTYTWYWQDENVYFQNDLKLRV---RILIDGTLIIFR-VKPEDSGKYTCVPSNSL 309

Query: 121 YCSKVAFPLEVVQKDS-CFNSPMKLPVHKLYIEYGIQR-ITCPNVDGYFPSSVKPTITWY 178
             S  A     VQ  +   N P   PV  +Y+  GI   I CP VD   P++V   + W 
Sbjct: 310 GRSPSASAYLTVQYPARVLNMP---PV--IYVPVGIHGYIRCP-VDAEPPATV---VKWN 360

Query: 179 MGCYKIQ---NFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVG 235
                +Q   N    + E  ++    A     G YTCV   P N        TL      
Sbjct: 361 KDGRPLQVEKNLGWTLMEDGSIRIEEATEEALGTYTCV---PYN--------TLGTMGQS 409

Query: 236 SPKNAV--PPVIHSPNDHVVYEKEPGEELLIPC 266
           +P   V   P   +      Y +E G ELLIPC
Sbjct: 410 APARLVLKDPPYFTVLPGWEYRQEAGRELLIPC 442


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score = 42.0 bits (97), Expect = 8e-04
 Identities = 62/261 (23%), Positives = 95/261 (36%), Gaps = 35/261 (13%)

Query: 91   RISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLY 150
            RI     +L    T + D G YTC++RN     +  F L V+        P  +      
Sbjct: 2434 RILSGGRMLRLMQTTMEDAGQYTCVVRNAAGEERKIFGLSVL-------VPPHIVGENTL 2486

Query: 151  IEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQ--NFNNVIPEGMNLSFLIALISNNG 208
             +  ++      +      +  P ITW+     +Q    +++I  G  L      + + G
Sbjct: 2487 EDVKVKEKQSVTLTCEVTGNPVPEITWHKDGQPLQEDEAHHIISGGRFLQITNVQVPHTG 2546

Query: 209  NYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTV 268
             YTC+ + P      H +R+ ++ V  SP  A      +P D  V    P     + C  
Sbjct: 2547 RYTCLASSPAG----HKSRSFSLNVFVSPTIAGVGSDGNPEDVTVILNSPTS---LVCEA 2599

Query: 269  YFSFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTEDETRT-QILSIKKVTSEDLK 327
            Y          + W  DG          T  ES  + R     RT QIL+      ED  
Sbjct: 2600 Y----SYPPATITWFKDG----------TPLESNRNIRILPGGRTLQILN----AQEDNA 2641

Query: 328  RSYVCHARSAKGEVAKAAKVK 348
              Y C A +  GE+ K  +VK
Sbjct: 2642 GRYSCVATNEAGEMIKHYEVK 2662



 Score = 41.6 bits (96), Expect = 0.001
 Identities = 35/133 (26%), Positives = 55/133 (41%), Gaps = 12/133 (9%)

Query: 98   VLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQR 157
            +L    T + D G Y C+  NT   +K  F L V    S      +   +   +      
Sbjct: 2927 ILQILNTQITDIGRYVCVAENTAGSAKKYFNLNVHVPPSVIGPKSE---NLTVVVNNFIS 2983

Query: 158  ITCPNVDGYFPSSVKPTITWYMGCYKIQNFNN--VIPEGMNLSFLIALISNNGNYTCVVT 215
            +TC  V G+ P    P ++W      I+   N  ++P G  L  + A +S+ G YTC+  
Sbjct: 2984 LTC-EVSGFPP----PDLSWLKNEQPIKLNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAI 3038

Query: 216  YP--ENGRTFHLT 226
                E+ + F LT
Sbjct: 3039 NQAGESKKKFSLT 3051



 Score = 38.1 bits (87), Expect = 0.012
 Identities = 68/303 (22%), Positives = 108/303 (35%), Gaps = 79/303 (26%)

Query: 67   TLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVA 126
            +L WY   Q    ++ +N       I+     L  +   ++DTG YTC+  N     ++ 
Sbjct: 2705 SLSWYKDGQPLKSDDHVN-------IAANGHTLQIKEAQISDTGRYTCVASNIAGEDELD 2757

Query: 127  FPLEVV----------------------QKDSCFNSPMKLPVHKLYIEYGIQRITCPNVD 164
            F + +                        KD   N+P+ L     Y E            
Sbjct: 2758 FDVNIQVPPSFQKLWEIGNMLDTGRNGEAKDVIINNPISL-----YCETN---------- 2802

Query: 165  GYFPSSVKPTITWYMGCYKIQNFNNVI--PEGMNLSFLIALISNNGNYTCVVTYPENGRT 222
                ++  PT+TWY   + + + + V+  P G  L    A + + G YTCV    E G  
Sbjct: 2803 ----AAPPPTLTWYKDGHPLTSSDKVLILPGGRVLQIPRAKVEDAGRYTCVAV-NEAGED 2857

Query: 223  FHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKE--PGEELLIPCTVYFSFLMDSRNEV 280
               +    V+V+      VPP+I   N  +  E      +  LI C    S     RN  
Sbjct: 2858 ---SLQYDVRVL------VPPIIKGANSDLPEEVTVLVNKSALIEC--LSSGSPAPRNS- 2905

Query: 281  WWTIDGKKPDDITIDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGE 340
             W  DG+      ++   ++ +S+ R      TQI  I +         YVC A +  G 
Sbjct: 2906 -WQKDGQP----LLEDDHHKFLSNGRILQILNTQITDIGR---------YVCVAENTAGS 2951

Query: 341  VAK 343
              K
Sbjct: 2952 AKK 2954



 Score = 37.4 bits (85), Expect = 0.021
 Identities = 39/180 (21%), Positives = 67/180 (37%), Gaps = 14/180 (7%)

Query: 72   WTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEV 131
            W + D    +P+N      +I     VL    TLL D G YTC+  N    ++    L V
Sbjct: 1860 WLKDD----QPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATNAAGETQQHIQLHV 1915

Query: 132  VQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNV- 190
             +  S  ++   L  ++  +     ++ C         +  P ITWY     +    ++ 
Sbjct: 1916 HEPPSLEDAGKML--NETVLVSNPVQLECKAA-----GNPVPVITWYKDNRLLSGSTSMT 1968

Query: 191  -IPEGMNLSFLIALISNNGNYTCVVTYPENG-RTFHLTRTLTVKVVGSPKNAVPPVIHSP 248
             +  G  +    A IS+ G Y CV          F+  +      +    N V  V+++P
Sbjct: 1969 FLNRGQIIDIESAQISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAVVVNNP 2028



 Score = 37.4 bits (85), Expect = 0.021
 Identities = 40/140 (28%), Positives = 59/140 (42%), Gaps = 13/140 (9%)

Query: 107  NDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGY 166
            +D+GNYTC+  N    ++  + L +    S   + +   V  L  E     + C N +G 
Sbjct: 3217 SDSGNYTCIASNMEGKAQKYYFLSIQVPPSVAGAEIPSDVSVLLGEN--VELVC-NANG- 3272

Query: 167  FPSSVKPTITWYMGCYKIQNFNN----VIPEGMNLSFLIALISNNGNYTCVVTYP--ENG 220
             P+   P I W      I +       V   G  L+   AL S+ G YTCV T P  E  
Sbjct: 3273 IPT---PLIQWLKDGKPIASGETERIRVSANGSTLNIYGALTSDTGKYTCVATNPAGEED 3329

Query: 221  RTFHLTRTLTVKVVGSPKNA 240
            R F+L   +T  + G+   A
Sbjct: 3330 RIFNLNVYVTPTIRGNKDEA 3349



 Score = 37.0 bits (84), Expect = 0.027
 Identities = 36/149 (24%), Positives = 62/149 (41%), Gaps = 12/149 (8%)

Query: 92   ISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYI 151
            I  E  +L  +   ++DTG Y C+  N    +   + L V    S   +  + P +   +
Sbjct: 2341 ILDEGHILQLKNIHVSDTGRYVCVAVNVAGMTDKKYDLSVHAPPSIIGN-HRSPENISVV 2399

Query: 152  EYGIQRITCPNVDGYFPSSVK-PTITWYMGCYKIQNFNNV--IPEGMNLSFLIALISNNG 208
            E     +TC        S +  P+ITW+   + +   N+V  +  G  L  +   + + G
Sbjct: 2400 EKNSVSLTCE------ASGIPLPSITWFKDGWPVSLSNSVRILSGGRMLRLMQTTMEDAG 2453

Query: 209  NYTCVV--TYPENGRTFHLTRTLTVKVVG 235
             YTCVV     E  + F L+  +   +VG
Sbjct: 2454 QYTCVVRNAAGEERKIFGLSVLVPPHIVG 2482



 Score = 35.8 bits (81), Expect = 0.060
 Identities = 34/147 (23%), Positives = 58/147 (39%), Gaps = 9/147 (6%)

Query: 106  LNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDG 165
            ++D G YTC+  N    SK  F L V    S     +K    +      ++  T  +++ 
Sbjct: 3027 VSDGGEYTCIAINQAGESKKKFSLTVYVPPS-----IKDHDSESLSVVNVREGTSVSLEC 3081

Query: 166  YFPSSVKPTITWYMGCYKIQNFNNV--IPEGMNLSFLIALISNNGNYTC--VVTYPENGR 221
               +   P ITWY     I    +V  + +G  L    A +S+ G Y C  +     + +
Sbjct: 3082 ESNAVPPPVITWYKNGRMITESTHVEILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDK 3141

Query: 222  TFHLTRTLTVKVVGSPKNAVPPVIHSP 248
             FHL   +   + G  +  +   I +P
Sbjct: 3142 NFHLNVYVPPSIEGPEREVIVETISNP 3168



 Score = 34.3 bits (77), Expect = 0.18
 Identities = 34/139 (24%), Positives = 59/139 (42%), Gaps = 14/139 (10%)

Query: 106  LNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDG 165
            ++D G Y C+  N+   +++ + L+V    S   S   + V    +     R+ C     
Sbjct: 1983 ISDAGIYKCVAINSAGATELFYSLQVHVAPSISGSNNMVAV----VVNNPVRLECEARG- 2037

Query: 166  YFPSSVKPTITWYMGCYKIQNFNN---VIPEGMNLSFLIALISNNGNYTCVVTYP--ENG 220
              P+   P++TW      + +F+N   V+  G  L+   A IS+ G YTCV      E  
Sbjct: 2038 -IPA---PSLTWLKDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVNAAGEKQ 2093

Query: 221  RTFHLTRTLTVKVVGSPKN 239
            R   L   +   ++G  +N
Sbjct: 2094 RDIDLRVYVPPNIMGEEQN 2112



 Score = 34.3 bits (77), Expect = 0.18
 Identities = 32/132 (24%), Positives = 55/132 (41%), Gaps = 14/132 (10%)

Query: 92   ISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYI 151
            I  +  +L  +   ++DTG Y C   N        F L V    S     ++ P  ++ +
Sbjct: 3108 ILADGQMLHIKKAEVSDTGQYVCRAINVAGRDDKNFHLNVYVPPS-----IEGPEREVIV 3162

Query: 152  EYGIQRITCP-NVDGYFPSSVKPTITWYMGCYKIQNFNN----VIPEGMNLSFLIALISN 206
            E     +T   +  G  P    PTI W     +I+N ++    ++  G  L    +  S+
Sbjct: 3163 ETISNPVTLTCDATGIPP----PTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSD 3218

Query: 207  NGNYTCVVTYPE 218
            +GNYTC+ +  E
Sbjct: 3219 SGNYTCIASNME 3230



 Score = 33.1 bits (74), Expect = 0.39
 Identities = 63/265 (23%), Positives = 96/265 (36%), Gaps = 48/265 (18%)

Query: 89   ENRISKEKDVLWFRPTLLNDTGNYTCMLRN------TTYCSKVAFPLEVVQKDSCFNSPM 142
            E+ +S     L       +D G YTC+  N      T     V  P  V   +  +N+  
Sbjct: 1216 EHHVSNPDGTLSIDQATPSDAGIYTCVATNIAGTDETEITLHVQEPPTVEDLEPPYNTTF 1275

Query: 143  KLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFN---NVIPEGMNLSF 199
            +  V    IE+      CP        + KPTI W     ++       +++ +G  L  
Sbjct: 1276 QERVANQRIEF-----PCP-----AKGTPKPTIKWLHNGRELTGREPGISILEDGTLLVI 1325

Query: 200  LIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPG 259
                  +NG Y CV    E G T    R   +KV       VPPVI         +KE  
Sbjct: 1326 ASVTPYDNGEYICVAV-NEAGTT---ERKYNLKV------HVPPVIK--------DKEQ- 1366

Query: 260  EELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRT-EDETRTQILSI 318
                       S L++    ++  ++G  P  I +    N  ++ S T +     +IL +
Sbjct: 1367 -------VTNVSVLLNQLTNLFCEVEG-TPSPIIMWYKDNVQVTESSTIQTVNNGKILKL 1418

Query: 319  KKVTSEDLKRSYVCHARSAKGEVAK 343
             + T ED  R Y C A +  G   K
Sbjct: 1419 FRATPEDAGR-YSCKAINIAGTSQK 1442



 Score = 31.2 bits (69), Expect = 1.5
 Identities = 31/115 (26%), Positives = 44/115 (38%), Gaps = 15/115 (13%)

Query: 106  LNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRIT--CPNV 163
            +++TG Y CM  NT    K  F + V    +  +S +   V   Y    +Q I    PN 
Sbjct: 1797 VSNTGLYRCMAANTAGDHKKEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIANGIPN- 1855

Query: 164  DGYFPSSVKPTITWYMGCYKI---QNFNNVIPEGMNLSFLIALISNNGNYTCVVT 215
                     P+ITW      +   Q    +   G  L     L+ + G YTCV T
Sbjct: 1856 ---------PSITWLKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVAT 1901



 Score = 30.8 bits (68), Expect = 1.9
 Identities = 37/155 (23%), Positives = 59/155 (38%), Gaps = 23/155 (14%)

Query: 97   DVLWFRPTLLNDTGNYTCMLRNTT------YCSKVAFPLEVVQKDSCFNSPMKLPVHKLY 150
            +VL      + DTG YTC+  +        Y  +V  P  +   D     P  + V +  
Sbjct: 3582 EVLRISTAQVEDTGRYTCLASSPAGDDDKEYLVRVHVPPNIAGTD----EPRDITVLR-- 3635

Query: 151  IEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNV--IPEGMNLSFLIALISNNG 208
                 +++T        P    P ITW     ++Q    V  +  G  L    A + +  
Sbjct: 3636 ----NRQVTLECKSDAVP---PPVITWLRNGERLQATPRVRILSGGRYLQINNADLGDTA 3688

Query: 209  NYTCVVT--YPENGRTFHLTRTLTVKVVGSPKNAV 241
            NYTCV +    +  R F LT  +   + G P++ V
Sbjct: 3689 NYTCVASNIAGKTTREFILTVNVPPNIKGGPQSLV 3723



 Score = 30.4 bits (67), Expect = 2.5
 Identities = 41/178 (23%), Positives = 61/178 (34%), Gaps = 27/178 (15%)

Query: 95   EKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYG 154
            E   L  +   + DTG Y CM  N     +    L+V    S    P  + V        
Sbjct: 3764 ENGFLHIQSAHVTDTGRYLCMATNAAGTDRRRIDLQVHVPPSIAPGPTNMTV-----IVN 3818

Query: 155  IQRITCPNVDGYFPSSVKPTITWYMGCYKI-----QNFNNVIPEGMNLSFLIALISNNGN 209
            +Q        G      KP+I W    + +     QN   ++  G +L  +   + +   
Sbjct: 3819 VQTTLACEATGI----PKPSINWRKNGHLLNVDQNQNSYRLLSSG-SLVIISPSVDDTAT 3873

Query: 210  YTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCT 267
            Y C VT          T  LTV+V        P +   P D +V +  P    +I CT
Sbjct: 3874 YECTVT--NGAGDDKRTVDLTVQV-------PPSIADEPTDFLVTKHAPA---VITCT 3919



 Score = 29.6 bits (65), Expect = 4.3
 Identities = 61/279 (21%), Positives = 98/279 (35%), Gaps = 62/279 (22%)

Query: 72   WTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEV 131
            W +  R + E I  R+     S    + + +P    D G+YTCM  N    S  +  L V
Sbjct: 4112 WHKDGRAIVESIRQRVLS---SGSLQIAFVQP---GDAGHYTCMAANVAGSSSTSTKLTV 4165

Query: 132  VQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITW---------YMGCY 182
                     P        Y      +   P V    P+   P I W          +G Y
Sbjct: 4166 ------HVPPRIRSTEGHYTVNENSQAILPCVADGIPT---PAINWKKDNVLLANLLGKY 4216

Query: 183  KIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVP 242
              + +  +I E +       ++ ++G YTCV     N      T T+++ V     + +P
Sbjct: 4217 TAEPYGELILENV-------VLEDSGFYTCVA----NNAAGEDTHTVSLTV-----HVLP 4260

Query: 243  PVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINESI 302
                 P D        GE+L + C      L     ++ W              T N +I
Sbjct: 4261 TFTELPGD---VSLNKGEQLRLSCKATGIPL----PKLTW--------------TFNNNI 4299

Query: 303  SHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAKGEV 341
              +  +       L I++V+ ED   +YVC A ++ G V
Sbjct: 4300 IPAHFDSVNGHSELVIERVSKED-SGTYVCTAENSVGFV 4337


>gi|110349719 titin isoform N2-A [Homo sapiens]
          Length = 33423

 Score = 40.0 bits (92), Expect = 0.003
 Identities = 62/244 (25%), Positives = 91/244 (37%), Gaps = 54/244 (22%)

Query: 107  NDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGY 166
            +D GNYTC+  N     +    L V +  S    P  L V              P  +  
Sbjct: 5865 SDMGNYTCVAANVAGSDECRAVLTVQEPPSFVKEPEPLEV-------------LPGKNVT 5911

Query: 167  FPSSVKPT----ITWYMGCYKIQN-------FNNVIPEGMNLSFLIALISNNGNYTCVVT 215
            F S ++ T    + W+ G  ++         F + + E   L      IS +G YTCVV+
Sbjct: 5912 FTSVIRGTPPFKVNWFRGARELVKGDRCNIYFEDTVAE---LELFNIDISQSGEYTCVVS 5968

Query: 216  YPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMD 275
               N      T  L VK   +        +   +DH V   EPG+ +++  T Y   L  
Sbjct: 5969 --NNAGQASCTTRLFVKEPAA-------FLKRLSDHSV---EPGKSIILEST-YTGTLPI 6015

Query: 276  SRNEVWWTIDGKKPDDITIDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHAR 335
            S   V W  DG        ++T +E  +   TE   +T IL I   T  D  + Y C   
Sbjct: 6016 S---VTWKKDG-------FNITTSEKCNIVTTE---KTCILEILNSTKRDAGQ-YSCEIE 6061

Query: 336  SAKG 339
            +  G
Sbjct: 6062 NEAG 6065



 Score = 40.0 bits (92), Expect = 0.003
 Identities = 63/249 (25%), Positives = 105/249 (42%), Gaps = 48/249 (19%)

Query: 107  NDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGY 166
            +D+G+YTC+  N     + + PL V +  S    P  + V           +T  NV   
Sbjct: 7747 SDSGDYTCIATNMAGSDECSAPLTVREPPSFVQKPDPMDV-----------LTGTNVT-- 7793

Query: 167  FPSSVKPT----ITWYMGCYKI---QNFNNVIPEGM-NLSFLIALISNNGNYTCVVTYPE 218
            F S VK T    ++W+ G  ++      N  + + +  L       S +G YTC+V+  E
Sbjct: 7794 FTSIVKGTPPFSVSWFKGSSELVPGDRCNVSLEDSVAELELFDVDTSQSGEYTCIVS-NE 7852

Query: 219  NGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRN 278
             G+    T  L +K       A    +   ND   Y  E G+ L++  T    F      
Sbjct: 7853 AGKA-SCTTHLYIK-------APAKFVKRLND---YSIEKGKPLILEGT----FTGTPPI 7897

Query: 279  EVWWTIDGKKPDDITIDVTINESISHSRTEDETRTQILSIKKVTSEDLKRSYVCHARSAK 338
             V W  +G       I+VT ++  + + TE   ++ IL I   T ED  + Y C+  +A 
Sbjct: 7898 SVTWKKNG-------INVTPSQRCNITTTE---KSAILEIPSSTVEDAGQ-YNCYIENAS 7946

Query: 339  GEVAKAAKV 347
            G+ + +A++
Sbjct: 7947 GKDSCSAQI 7955



 Score = 33.9 bits (76), Expect = 0.23
 Identities = 40/165 (24%), Positives = 64/165 (38%), Gaps = 33/165 (20%)

Query: 66   LTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNT--TYCS 123
            +T+ WY  + D  L     +R      +     L F    +ND+G YTC   N+  T  S
Sbjct: 6108 ITVSWY--KGDTKLRPTPEYR---TYFTNNVATLVFNKVNINDSGEYTCKAENSIGTASS 6162

Query: 124  KVAFPLEVVQKDSCFNSPMK-------LPVHKLYIEYGIQRITCPNVDGYFPSSVKPTIT 176
            K  F ++  Q    F   +K       LPV           +TC  ++G  P  V     
Sbjct: 6163 KTVFRIQERQLPPSFARQLKDIEQTVGLPV----------TLTC-RLNGSAPIQV----C 6207

Query: 177  WYMGCYKIQNFNNV----IPEGMNLSFLIALISNNGNYTCVVTYP 217
            WY     +++  N+    +     L  L   +S++G Y+C  + P
Sbjct: 6208 WYRDGVLLRDDENLQTSFVDNVATLKILQTDLSHSGQYSCSASNP 6252



 Score = 30.0 bits (66), Expect = 3.3
 Identities = 29/119 (24%), Positives = 47/119 (39%), Gaps = 13/119 (10%)

Query: 106  LNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDG 165
            +ND GN+TC   N+      +  L V +  S    P    V             C  +  
Sbjct: 4177 MNDAGNFTCRATNSVGSKDSSGALIVQEPPSFVTKPGSKDVLP-------GSAVC--LKS 4227

Query: 166  YFPSSVKPTITWYMGCYKIQNFNN--VIPEGMNLSFLIALI--SNNGNYTCVVTYPENG 220
             F  S   TI W+ G  ++ +  +  +  E +  S  + L+  S++G YTC V+    G
Sbjct: 4228 TFQGSTPLTIRWFKGNKELVSGGSCYITKEALESSLELYLVKTSDSGTYTCKVSNVAGG 4286



 Score = 29.3 bits (64), Expect = 5.6
 Identities = 23/86 (26%), Positives = 41/86 (47%), Gaps = 17/86 (19%)

Query: 140  SPMKLPVHKLYIEYGIQRITCP---------NVDGYFPSSVKPTITWYMGCYKIQ---NF 187
            +P+++PV    +  G++ +T           ++ GY PS   PT+TWY   Y+I+   +F
Sbjct: 934  APVEIPVTPPTLVSGLKNVTVIEGESVTLECHISGY-PS---PTVTWYREDYQIESSIDF 989

Query: 188  NNVIPEGM-NLSFLIALISNNGNYTC 212
                  G+  L    A   ++G +TC
Sbjct: 990  QITFQSGIARLMIREAFAEDSGRFTC 1015



 Score = 28.9 bits (63), Expect = 7.4
 Identities = 21/91 (23%), Positives = 40/91 (43%), Gaps = 7/91 (7%)

Query: 41   EPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEKDVLW 100
            EP+RI     + F ++      S  + ++WY  + + +++E   FR+          VL 
Sbjct: 7312 EPSRIVKQ--DEFTRYECKIGGSPEIKVLWY--KDETEIQESSKFRMS---FVDSVAVLE 7364

Query: 101  FRPTLLNDTGNYTCMLRNTTYCSKVAFPLEV 131
                 + D+G+YTC   N    +  +  L+V
Sbjct: 7365 MHNLSVEDSGDYTCEAHNAAGSASSSTSLKV 7395



 Score = 28.9 bits (63), Expect = 7.4
 Identities = 14/46 (30%), Positives = 22/46 (47%)

Query: 99    LWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKL 144
             L  R T + DTG YT  L+N T  +     + ++ K      P+K+
Sbjct: 29796 LTIRETTIRDTGEYTLELKNVTGTTSETIKVIILDKPGPPTGPIKI 29841


>gi|28373126 contactin 4 isoform c precursor [Homo sapiens]
          Length = 698

 Score = 39.7 bits (91), Expect = 0.004
 Identities = 52/196 (26%), Positives = 75/196 (38%), Gaps = 31/196 (15%)

Query: 87  LPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPV 146
           L  +RI  E+  L      L+D G Y C+  N          L V+     F+  +    
Sbjct: 29  LTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTL---- 84

Query: 147 HKLYIEYGIQRITCPNVDGYF------PSSVKPTITWYMGCYKI-QNFNNVIPEGMNLSF 199
                   ++R+T   V G         +S KP  TW  G   + +N    I E  NL  
Sbjct: 85  --------LKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRI 136

Query: 200 LIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPG 259
           +    S+ G+YTC+ T   +  T   T  L VK     +  VPP   S  D  V     G
Sbjct: 137 INVTKSDAGSYTCIAT--NHFGTASSTGNLVVK--DPTRVMVPP---SSMDVTV-----G 184

Query: 260 EELLIPCTVYFSFLMD 275
           E +++PC V     +D
Sbjct: 185 ESIVLPCQVTHDHSLD 200


>gi|28373122 contactin 4 isoform a precursor [Homo sapiens]
          Length = 1026

 Score = 39.7 bits (91), Expect = 0.004
 Identities = 52/196 (26%), Positives = 75/196 (38%), Gaps = 31/196 (15%)

Query: 87  LPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPV 146
           L  +RI  E+  L      L+D G Y C+  N          L V+     F+  +    
Sbjct: 357 LTRDRIQIEQGTLNITIVNLSDAGMYQCLAENKHGVIFSNAELSVIAVGPDFSRTL---- 412

Query: 147 HKLYIEYGIQRITCPNVDGYF------PSSVKPTITWYMGCYKI-QNFNNVIPEGMNLSF 199
                   ++R+T   V G         +S KP  TW  G   + +N    I E  NL  
Sbjct: 413 --------LKRVTLVKVGGEVVIECKPKASPKPVYTWKKGRDILKENERITISEDGNLRI 464

Query: 200 LIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPG 259
           +    S+ G+YTC+ T   +  T   T  L VK     +  VPP   S  D  V     G
Sbjct: 465 INVTKSDAGSYTCIAT--NHFGTASSTGNLVVK--DPTRVMVPP---SSMDVTV-----G 512

Query: 260 EELLIPCTVYFSFLMD 275
           E +++PC V     +D
Sbjct: 513 ESIVLPCQVTHDHSLD 528



 Score = 34.3 bits (77), Expect = 0.18
 Identities = 63/236 (26%), Positives = 89/236 (37%), Gaps = 31/236 (13%)

Query: 37  VFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDLEEPINFRLPENRISKEK 96
           +F  EP+ +  PL     K   +            W     D++  ++FR        E 
Sbjct: 27  IFIQEPSPVMFPLDSEEKKVKLNCEVKGNPKPHIRWKLNGTDVDTGMDFRYSV----VEG 82

Query: 97  DVLWFRPTLLNDTGNYTCMLRNT--TYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYG 154
            +L   P    D G Y C   N+  T  S+ A  L+    D+ F +  +  V    +  G
Sbjct: 83  SLLINNPNKTQDAGTYQCTATNSFGTIVSREA-KLQFAYLDN-FKTRTRSTVS---VRRG 137

Query: 155 IQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNN--VIPEGMNLSFLIALISNNGNYTC 212
              +    + G  P S + +  W    Y     N   V  E  NL       S+ GNYTC
Sbjct: 138 QGMVL---LCGPPPHSGELSYAWIFNEYPSYQDNRRFVSQETGNLYIAKVEKSDVGNYTC 194

Query: 213 VVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTV 268
           VVT   N  T H       KV+G P    P ++   ND V+ E EP  E+  P TV
Sbjct: 195 VVT---NTVTNH-------KVLGPP---TPLILR--NDGVMGEYEPKIEVQFPETV 235


>gi|169178458 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3874

 Score = 38.9 bits (89), Expect = 0.007
 Identities = 32/137 (23%), Positives = 67/137 (48%), Gaps = 11/137 (8%)

Query: 108  DTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYF 167
            D+G Y+C+  N    ++  F +EV+   S  N  ++  +  L  +     + C NV G+ 
Sbjct: 1226 DSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVL--DGQTAHLMC-NVTGH- 1281

Query: 168  PSSVKPTITWYMGCYKIQ--NFNNVIPEGMNLSFLIALISNNGNYTCVV--TYPENGRTF 223
                +P +TW+     +   + +++ P+G+ L  L A +S+ G+Y+C+      E  + F
Sbjct: 1282 ---PQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHF 1338

Query: 224  HLTRTLTVKVVGSPKNA 240
             L+  L   ++G  +++
Sbjct: 1339 QLSVLLAPTILGGAEDS 1355



 Score = 33.1 bits (74), Expect = 0.39
 Identities = 47/207 (22%), Positives = 76/207 (36%), Gaps = 42/207 (20%)

Query: 92  ISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYI 151
           +S +  VL      L+D G+Y C+  N    +++ + L  V        P  LP   + +
Sbjct: 743 VSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLR-VNVPPRITLPPSLP-GPVLV 800

Query: 152 EYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFN----NVIPEGMNLSFLIALISNN 207
              + R+TC N  G    +  PT+ W      +         V P G  L+   A  S++
Sbjct: 801 NTPV-RLTC-NATG----APSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDS 854

Query: 208 GNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCT 267
           G Y+CV                 V  VG  +  V   +H P   +      GEEL +   
Sbjct: 855 GRYSCV----------------AVSAVGEDRQDVVLQVHMPPSIL------GEELNVSVV 892

Query: 268 VYFSFLMDSRNEV-------WWTIDGK 287
              S  ++ ++         WW  DG+
Sbjct: 893 ANESVALECQSHAMPPPVLSWWK-DGR 918



 Score = 32.7 bits (73), Expect = 0.51
 Identities = 38/145 (26%), Positives = 59/145 (40%), Gaps = 15/145 (10%)

Query: 106 LNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDG 165
           L D G YTC   N    SK    L+V+   +        PV+K  +E     + C    G
Sbjct: 666 LRDEGIYTCAATNLAGESKREVALKVLVPPNIEPG----PVNKAVLENASVTLEC-LASG 720

Query: 166 YFPSSVKPTITWYMGCYKIQNFNNVI--PEGMNLSFLIALISNNGNYTCVVTYPENGRTF 223
             P    P ++W+ G   + ++  V    +G  L    A +S+ G+Y CV +      + 
Sbjct: 721 VPP----PDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVAS--NVAGST 774

Query: 224 HLTRTLTVKVVGSPKNAVPPVIHSP 248
            L   L V V   P+  +PP +  P
Sbjct: 775 ELRYGLRVNV--PPRITLPPSLPGP 797



 Score = 29.3 bits (64), Expect = 5.6
 Identities = 50/222 (22%), Positives = 84/222 (37%), Gaps = 34/222 (15%)

Query: 72   WTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEV 131
            W R    L+E  + + PE         L  +     D+G+Y+C  RN    + VAF +E+
Sbjct: 2424 WHRDGIVLQEDAHTQFPERG-----RFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEI 2478

Query: 132  VQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFN--- 188
                +  + P   P   + +    Q    P      P+   P ++W      +   +   
Sbjct: 2479 HTVPTIRSGP---PAVNVSVN---QTALLPCQADGVPA---PLVSWRKDRVPLDPRSPRF 2529

Query: 189  NVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSP 248
             ++PEG +L     L  + G+Y C+ +   +  +    R L V          P +  SP
Sbjct: 2530 EILPEG-SLRIQPVLAQDAGHYLCLAS--NSAGSDRQGRDLRVL-------EPPAIAPSP 2579

Query: 249  NDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPD 290
            ++  +    P    L+PC    S        VWW  DG+K D
Sbjct: 2580 SNLTLTAHTPA---LLPCEASGS---PKPLVVWWK-DGQKLD 2614


>gi|239749684 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 5065

 Score = 38.9 bits (89), Expect = 0.007
 Identities = 32/137 (23%), Positives = 67/137 (48%), Gaps = 11/137 (8%)

Query: 108  DTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYF 167
            D+G Y+C+  N    ++  F +EV+   S  N  ++  +  L  +     + C NV G+ 
Sbjct: 2417 DSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVL--DGQTAHLMC-NVTGH- 2472

Query: 168  PSSVKPTITWYMGCYKIQ--NFNNVIPEGMNLSFLIALISNNGNYTCVV--TYPENGRTF 223
                +P +TW+     +   + +++ P+G+ L  L A +S+ G+Y+C+      E  + F
Sbjct: 2473 ---PQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHF 2529

Query: 224  HLTRTLTVKVVGSPKNA 240
             L+  L   ++G  +++
Sbjct: 2530 QLSVLLAPTILGGAEDS 2546



 Score = 33.1 bits (74), Expect = 0.39
 Identities = 47/207 (22%), Positives = 76/207 (36%), Gaps = 42/207 (20%)

Query: 92   ISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYI 151
            +S +  VL      L+D G+Y C+  N    +++ + L  V        P  LP   + +
Sbjct: 1934 VSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLR-VNVPPRITLPPSLP-GPVLV 1991

Query: 152  EYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFN----NVIPEGMNLSFLIALISNN 207
               + R+TC N  G    +  PT+ W      +         V P G  L+   A  S++
Sbjct: 1992 NTPV-RLTC-NATG----APSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDS 2045

Query: 208  GNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCT 267
            G Y+CV                 V  VG  +  V   +H P   +      GEEL +   
Sbjct: 2046 GRYSCV----------------AVSAVGEDRQDVVLQVHMPPSIL------GEELNVSVV 2083

Query: 268  VYFSFLMDSRNEV-------WWTIDGK 287
               S  ++ ++         WW  DG+
Sbjct: 2084 ANESVALECQSHAMPPPVLSWWK-DGR 2109



 Score = 32.7 bits (73), Expect = 0.51
 Identities = 38/145 (26%), Positives = 59/145 (40%), Gaps = 15/145 (10%)

Query: 106  LNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDG 165
            L D G YTC   N    SK    L+V+   +        PV+K  +E     + C    G
Sbjct: 1857 LRDEGIYTCAATNLAGESKREVALKVLVPPNIEPG----PVNKAVLENASVTLEC-LASG 1911

Query: 166  YFPSSVKPTITWYMGCYKIQNFNNVI--PEGMNLSFLIALISNNGNYTCVVTYPENGRTF 223
              P    P ++W+ G   + ++  V    +G  L    A +S+ G+Y CV +      + 
Sbjct: 1912 VPP----PDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVAS--NVAGST 1965

Query: 224  HLTRTLTVKVVGSPKNAVPPVIHSP 248
             L   L V V   P+  +PP +  P
Sbjct: 1966 ELRYGLRVNV--PPRITLPPSLPGP 1988



 Score = 29.3 bits (64), Expect = 5.6
 Identities = 50/222 (22%), Positives = 84/222 (37%), Gaps = 34/222 (15%)

Query: 72   WTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEV 131
            W R    L+E  + + PE         L  +     D+G+Y+C  RN    + VAF +E+
Sbjct: 3615 WHRDGIVLQEDAHTQFPERG-----RFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEI 3669

Query: 132  VQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFN--- 188
                +  + P   P   + +    Q    P      P+   P ++W      +   +   
Sbjct: 3670 HTVPTIRSGP---PAVNVSVN---QTALLPCQADGVPA---PLVSWRKDRVPLDPRSPRF 3720

Query: 189  NVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSP 248
             ++PEG +L     L  + G+Y C+ +   +  +    R L V          P +  SP
Sbjct: 3721 EILPEG-SLRIQPVLAQDAGHYLCLAS--NSAGSDRQGRDLRVL-------EPPAIAPSP 3770

Query: 249  NDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPD 290
            ++  +    P    L+PC    S        VWW  DG+K D
Sbjct: 3771 SNLTLTAHTPA---LLPCEASGS---PKPLVVWWK-DGQKLD 3805


>gi|169177000 PREDICTED: hemicentin 2 [Homo sapiens]
          Length = 3783

 Score = 38.9 bits (89), Expect = 0.007
 Identities = 32/137 (23%), Positives = 67/137 (48%), Gaps = 11/137 (8%)

Query: 108  DTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYF 167
            D+G Y+C+  N    ++  F +EV+   S  N  ++  +  L  +     + C NV G+ 
Sbjct: 1135 DSGLYSCLASNEAGEARRNFSVEVLVPPSIENEDLEEVIKVL--DGQTAHLMC-NVTGH- 1190

Query: 168  PSSVKPTITWYMGCYKIQ--NFNNVIPEGMNLSFLIALISNNGNYTCVV--TYPENGRTF 223
                +P +TW+     +   + +++ P+G+ L  L A +S+ G+Y+C+      E  + F
Sbjct: 1191 ---PQPKLTWFKDGRPLARGDAHHISPDGVLLQVLQANLSSAGHYSCIAANAVGEKTKHF 1247

Query: 224  HLTRTLTVKVVGSPKNA 240
             L+  L   ++G  +++
Sbjct: 1248 QLSVLLAPTILGGAEDS 1264



 Score = 33.1 bits (74), Expect = 0.39
 Identities = 47/207 (22%), Positives = 76/207 (36%), Gaps = 42/207 (20%)

Query: 92  ISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYI 151
           +S +  VL      L+D G+Y C+  N    +++ + L  V        P  LP   + +
Sbjct: 652 VSVDGRVLRIEQAQLSDAGSYRCVASNVAGSTELRYGLR-VNVPPRITLPPSLP-GPVLV 709

Query: 152 EYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFN----NVIPEGMNLSFLIALISNN 207
              + R+TC N  G    +  PT+ W      +         V P G  L+   A  S++
Sbjct: 710 NTPV-RLTC-NATG----APSPTLMWLKDGNPVSPAGTPGLQVFPGGRVLTLASARASDS 763

Query: 208 GNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCT 267
           G Y+CV                 V  VG  +  V   +H P   +      GEEL +   
Sbjct: 764 GRYSCV----------------AVSAVGEDRQDVVLQVHMPPSIL------GEELNVSVV 801

Query: 268 VYFSFLMDSRNEV-------WWTIDGK 287
              S  ++ ++         WW  DG+
Sbjct: 802 ANESVALECQSHAMPPPVLSWWK-DGR 827



 Score = 32.7 bits (73), Expect = 0.51
 Identities = 38/145 (26%), Positives = 59/145 (40%), Gaps = 15/145 (10%)

Query: 106 LNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDG 165
           L D G YTC   N    SK    L+V+   +        PV+K  +E     + C    G
Sbjct: 575 LRDEGIYTCAATNLAGESKREVALKVLVPPNIEPG----PVNKAVLENASVTLEC-LASG 629

Query: 166 YFPSSVKPTITWYMGCYKIQNFNNVI--PEGMNLSFLIALISNNGNYTCVVTYPENGRTF 223
             P    P ++W+ G   + ++  V    +G  L    A +S+ G+Y CV +      + 
Sbjct: 630 VPP----PDVSWFKGHQPVSSWMGVTVSVDGRVLRIEQAQLSDAGSYRCVAS--NVAGST 683

Query: 224 HLTRTLTVKVVGSPKNAVPPVIHSP 248
            L   L V V   P+  +PP +  P
Sbjct: 684 ELRYGLRVNV--PPRITLPPSLPGP 706



 Score = 29.3 bits (64), Expect = 5.6
 Identities = 25/110 (22%), Positives = 43/110 (39%), Gaps = 4/110 (3%)

Query: 108  DTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYF 167
            D G YTC++ N    +   + +EV+   S         V    ++  +        + + 
Sbjct: 1324 DAGQYTCVVTNELGEAVKNYHVEVLIPPSISKDDPLAEVGVKEVKTKVNSTLTLECESW- 1382

Query: 168  PSSVKPTITWYMGCYKIQNFNN--VIPEGMNLSFLIALISNNGNYTCVVT 215
             +   PTI WY     +   +   V+ EG  L      +S++G Y CV T
Sbjct: 1383 -AVPPPTIRWYKDGQPVTPSSRLQVLGEGRLLQIQPTQVSDSGRYLCVAT 1431



 Score = 29.3 bits (64), Expect = 5.6
 Identities = 50/222 (22%), Positives = 84/222 (37%), Gaps = 34/222 (15%)

Query: 72   WTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEV 131
            W R    L+E  + + PE         L  +     D+G+Y+C  RN    + VAF +E+
Sbjct: 2333 WHRDGIVLQEDAHTQFPERG-----RFLQLQALSTADSGDYSCTARNAAGSTSVAFRVEI 2387

Query: 132  VQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFN--- 188
                +  + P   P   + +    Q    P      P+   P ++W      +   +   
Sbjct: 2388 HTVPTIRSGP---PAVNVSVN---QTALLPCQADGVPA---PLVSWRKDRVPLDPRSPRF 2438

Query: 189  NVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSP 248
             ++PEG +L     L  + G+Y C+ +   +  +    R L V          P +  SP
Sbjct: 2439 EILPEG-SLRIQPVLAQDAGHYLCLAS--NSAGSDRQGRDLRVL-------EPPAIAPSP 2488

Query: 249  NDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPD 290
            ++  +    P    L+PC    S        VWW  DG+K D
Sbjct: 2489 SNLTLTAHTPA---LLPCEASGS---PKPLVVWWK-DGQKLD 2523


>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2a [Homo sapiens]
          Length = 1394

 Score = 38.5 bits (88), Expect = 0.009
 Identities = 56/284 (19%), Positives = 106/284 (37%), Gaps = 48/284 (16%)

Query: 71  YWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLE 130
           YW +    +++       E RIS     L    T  +D G YTC+  N     + + P E
Sbjct: 182 YWKKDKVRIDDK------EERISIRGGKLMISNTRKSDAGMYTCVGTNMV-GERDSDPAE 234

Query: 131 VVQKDSCFNSP--MKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFN 188
           +    + F  P  ++ P++++ +E       C  V G      +PT+ W      +    
Sbjct: 235 L----TVFERPTFLRRPINQVVLEEEAVEFRC-QVQG----DPQPTVRWKKDDADLPRGR 285

Query: 189 NVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSP 248
             I +   L     + ++ G Y C+            + TLTV+       A P  +  P
Sbjct: 286 YDIKDDYTLRIKKTMSTDEGTYMCIA--ENRVGKMEASATLTVR-------APPQFVVRP 336

Query: 249 NDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTE 308
            D +V +   G  +  PC        + +  V+W  +G +          N    +   +
Sbjct: 337 RDQIVAQ---GRTVTFPCET----KGNPQPAVFWQKEGSQ----------NLLFPNQPQQ 379

Query: 309 DETRTQILSIKKVTSEDLKRS----YVCHARSAKGEVAKAAKVK 348
             +R  +     +T  +++RS    Y+C A +  G +   A+++
Sbjct: 380 PNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLE 423


>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
           ROBO2b [Homo sapiens]
          Length = 1378

 Score = 38.5 bits (88), Expect = 0.009
 Identities = 56/284 (19%), Positives = 106/284 (37%), Gaps = 48/284 (16%)

Query: 71  YWTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLE 130
           YW +    +++       E RIS     L    T  +D G YTC+  N     + + P E
Sbjct: 166 YWKKDKVRIDDK------EERISIRGGKLMISNTRKSDAGMYTCVGTNMV-GERDSDPAE 218

Query: 131 VVQKDSCFNSP--MKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFN 188
           +    + F  P  ++ P++++ +E       C  V G      +PT+ W      +    
Sbjct: 219 L----TVFERPTFLRRPINQVVLEEEAVEFRC-QVQG----DPQPTVRWKKDDADLPRGR 269

Query: 189 NVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSP 248
             I +   L     + ++ G Y C+            + TLTV+       A P  +  P
Sbjct: 270 YDIKDDYTLRIKKTMSTDEGTYMCIA--ENRVGKMEASATLTVR-------APPQFVVRP 320

Query: 249 NDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTE 308
            D +V +   G  +  PC        + +  V+W  +G +          N    +   +
Sbjct: 321 RDQIVAQ---GRTVTFPCET----KGNPQPAVFWQKEGSQ----------NLLFPNQPQQ 363

Query: 309 DETRTQILSIKKVTSEDLKRS----YVCHARSAKGEVAKAAKVK 348
             +R  +     +T  +++RS    Y+C A +  G +   A+++
Sbjct: 364 PNSRCSVSPTGDLTITNIQRSDAGYYICQALTVAGSILAKAQLE 407


>gi|122937205 carcinoembryonic antigen-related cell adhesion
           molecule 18 [Homo sapiens]
          Length = 398

 Score = 35.0 bits (79), Expect = 0.10
 Identities = 47/218 (21%), Positives = 86/218 (39%), Gaps = 31/218 (14%)

Query: 70  WYWTRQDRDLEEPINFRLPE-----------NRISKEKDVLWFRPTLLNDTGNYTCMLRN 118
           WYW   D      I+ + P             R+++E  +L  RPT LNDTGNYT  +  
Sbjct: 122 WYWGANDSAGNMIISHKPPSAQQPGPMYTGRERVNREGSLL-IRPTALNDTGNYTVRVVA 180

Query: 119 TTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGYFPSSVKPTITWY 178
                +    LEV++      S + + V+   +   +  +    +           ITWY
Sbjct: 181 GNETQRATGWLEVLE----LGSNLGISVNASSLVENMDSVAADCLTNV------TNITWY 230

Query: 179 MGCYKIQNFN--NVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGS 236
           +      + +   + P+G  L  L     +      + ++PE    F  +  +++ V   
Sbjct: 231 VNDVPTSSSDRMTISPDGKTLVILRVSRYDRTIQCMIESFPE---IFQRSERISLTVAYG 287

Query: 237 PKNAVPPVIHSPND-HVVYEKEPGEELLIPCTVYFSFL 273
           P   +  +  +P+D + +   E G ++ + C  Y SFL
Sbjct: 288 PDYVL--LRSNPDDFNGIVTAEIGSQVEMECICY-SFL 322


>gi|98986445 carcinoembryonic antigen-related cell adhesion molecule
           5 preproprotein [Homo sapiens]
          Length = 702

 Score = 34.7 bits (78), Expect = 0.13
 Identities = 34/153 (22%), Positives = 61/153 (39%), Gaps = 22/153 (14%)

Query: 88  PENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCF--NSPMKLP 145
           P  ++S     L       ND   Y C ++N+   ++     + V  D  +  ++P+  P
Sbjct: 545 PRLQLSNGNRTLTLFNVTRNDARAYVCGIQNSVSANRS----DPVTLDVLYGPDTPIISP 600

Query: 146 VHKLYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNVIPEGMNLSFLIALIS 205
               Y+      ++C +      S+  P  +W +         N IP+       IA I+
Sbjct: 601 PDSSYLSGANLNLSCHSA-----SNPSPQYSWRI---------NGIPQQHTQVLFIAKIT 646

Query: 206 --NNGNYTCVVTYPENGRTFHLTRTLTVKVVGS 236
             NNG Y C V+    GR   + +++TV   G+
Sbjct: 647 PNNNGTYACFVSNLATGRNNSIVKSITVSASGT 679


>gi|75709184 contactin 3 [Homo sapiens]
          Length = 1028

 Score = 34.7 bits (78), Expect = 0.13
 Identities = 59/270 (21%), Positives = 102/270 (37%), Gaps = 39/270 (14%)

Query: 89  ENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHK 148
           E R   E   L      + D+G + C+  N       +  L+VV     F+   K P+ K
Sbjct: 361 EERTQIENGALTISNLSVTDSGMFQCIAENKHGLVYSSAELKVVASAPDFS---KNPMKK 417

Query: 149 LYIEYGIQRITCPNVDGYFPSSVKPTITWYMGCYKIQNFNNV--IPEGMNLSFLIALISN 206
           L     +Q  +  ++D    +S +   +W  G   +Q    +  + +G  L       ++
Sbjct: 418 LV---QVQVGSLVSLDCKPRASPRALSSWKKGDVSVQEHERISLLNDG-GLKIANVTKAD 473

Query: 207 NGNYTCVVT--YPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLI 264
            G YTC+    + +   T HL  T   ++  +P N    V              GE +++
Sbjct: 474 AGTYTCMAENQFGKANGTTHLVVTEPTRITLAPSNMDVSV--------------GESVIL 519

Query: 265 PCTVYFSFLMDSRNEVWWTIDGKKPDDITIDVTINESISHSRTEDETRTQILSIKKVTSE 324
           PC V    L+D      W  +G   D         +  SH      + +  L I+ +   
Sbjct: 520 PCQVQHDPLLDI--IFTWYFNGALAD-------FKKDGSHFEKVGGSSSGDLMIRNI--- 567

Query: 325 DLKRS--YVCHARSAKGEVAKAAKVKQKGN 352
            LK S  YVC  ++    V+ AA +  +G+
Sbjct: 568 QLKHSGKYVCMVQTGVDSVSSAADLIVRGS 597



 Score = 30.0 bits (66), Expect = 3.3
 Identities = 24/64 (37%), Positives = 32/64 (50%), Gaps = 15/64 (23%)

Query: 205 SNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLI 264
           S+ GNYTCVVT          +     +V+GSP    P V+ S  D V+ E EP  E+  
Sbjct: 189 SDVGNYTCVVT----------SMVTNARVLGSP---TPLVLRS--DGVMGEYEPKIEVQF 233

Query: 265 PCTV 268
           P T+
Sbjct: 234 PETL 237


>gi|7657361 contactin 6 [Homo sapiens]
          Length = 1028

 Score = 34.7 bits (78), Expect = 0.13
 Identities = 55/204 (26%), Positives = 80/204 (39%), Gaps = 33/204 (16%)

Query: 70  WY-WTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFP 128
           WY W +    L        PE RI  E   L      ++D+G Y C   N          
Sbjct: 348 WYTWLKNGERLN-------PEERIQIENGTLIITMLNVSDSGVYQCAAENKYQIIYANAE 400

Query: 129 LEVVQKDSCFN-SPMKLPVHKLYIEYGIQ-RITC-PNVDGYFPSSVKPTITWYMGCYKIQ 185
           L V+     F+ SP+K    K +++ G    I C PN    FP   +  I+W  G   ++
Sbjct: 401 LRVLASAPDFSKSPVK---KKSFVQVGGDIVIGCKPNA---FP---RAAISWKRGTETLR 451

Query: 186 NFNNV-IPEGMNLSFLIALISNNGNYTCVVTYPENGRTFHLTRTLTVKVVGSPKNAVPPV 244
               + + E  +L       S+ G+YTC+ T      T   T +L VK     +  V  V
Sbjct: 452 QSKRIFLLEDGSLKIYNITRSDAGSYTCIAT--NQFGTAKNTGSLIVK-----ERTVITV 504

Query: 245 IHSPNDHVVYEKEPGEELLIPCTV 268
             S  D  V     GE +++PC V
Sbjct: 505 PPSKMDVTV-----GESIVLPCQV 523



 Score = 28.5 bits (62), Expect = 9.6
 Identities = 24/96 (25%), Positives = 38/96 (39%), Gaps = 19/96 (19%)

Query: 25  DDWGLDTMRQIQVFEDEPARIKCPLFEHFLKFNYSTAHSAGLTLIWYWTRQDRDLEEPIN 84
           +D+   T   + V E +   + C    HF   +Y+            WT  D  L     
Sbjct: 122 EDFETKTRSTVSVREGQGVVLLCGPPPHFGDLSYA------------WTFNDNPL----- 164

Query: 85  FRLPENR--ISKEKDVLWFRPTLLNDTGNYTCMLRN 118
           +   +NR  +S+E   L+      +D GNYTC + N
Sbjct: 165 YVQEDNRRFVSQETGNLYIAKVEPSDVGNYTCFITN 200


>gi|20127422 Down syndrome cell adhesion molecule isoform CHD2-42
           precursor [Homo sapiens]
          Length = 2012

 Score = 33.9 bits (76), Expect = 0.23
 Identities = 61/251 (24%), Positives = 102/251 (40%), Gaps = 39/251 (15%)

Query: 107 NDTGNYTCMLRNTTYCSKVAFPLEVVQKDSCFNSPMKLPVHKLYIEYGIQRITCPNVDGY 166
           +D+G+Y C + N    +KV   L V Q      SP      K+    G Q     +V G 
Sbjct: 286 SDSGSYVCEVSNRYGTAKVIGRLYVKQPLKATISP-----RKVKSSVGSQVSLSCSVTG- 339

Query: 167 FPSSVKPTITWYMGCYKIQNFNNVIPEGMNLSFLI---ALISNNGNYTCVVTYPENGRTF 223
              +    ++WY     +    NV   G+N   LI    + S+ G Y C V      R  
Sbjct: 340 ---TEDQELSWYRNGEILNPGKNVRITGINHENLIMDHMVKSDGGAYQCFV------RKD 390

Query: 224 HLTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVYFSFLMDSRNEVWWT 283
            L+    V+VV   ++  P +I + ++ VV    P E + + C V  + L      + WT
Sbjct: 391 KLSAQDYVQVV--LEDGTPKIISAFSEKVV---SPAEPVSLMCNVKGTPL----PTITWT 441

Query: 284 IDGKKPDDITIDVTINESISHSRTEDET-RTQILSIKKVTSEDLKRS--YVCHARSAKGE 340
           +D         D  I +  SH  ++  T    ++S   ++S  ++    Y C A ++ G 
Sbjct: 442 LD---------DDPILKGGSHRISQMITSEGNVVSYLNISSSQVRDGGVYRCTANNSAGV 492

Query: 341 VAKAAKVKQKG 351
           V   A++  +G
Sbjct: 493 VLYQARINVRG 503


>gi|209977117 unc-5 homolog D [Homo sapiens]
          Length = 953

 Score = 33.9 bits (76), Expect = 0.23
 Identities = 17/39 (43%), Positives = 22/39 (56%)

Query: 80  EEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRN 118
           EEPI+    EN  ++    L  R   L+D+GNYTCM  N
Sbjct: 197 EEPIDSEQDENIDTRADHNLIIRQARLSDSGNYTCMAAN 235


>gi|11321597 kinase insert domain receptor precursor [Homo sapiens]
          Length = 1356

 Score = 33.5 bits (75), Expect = 0.30
 Identities = 45/165 (27%), Positives = 65/165 (39%), Gaps = 18/165 (10%)

Query: 107 NDTGNYTCMLRNTTYCSKVAFPLEVVQKDS-CFNSPMKLPVHKLYIEYGIQRITCP-NVD 164
           +D G YTC   +     K +  + V +K    F S M+  V     E    R+  P    
Sbjct: 300 SDQGLYTCAASSGLMTKKNSTFVRVHEKPFVAFGSGMESLVEATVGE----RVRIPAKYL 355

Query: 165 GYFPSSVKPTITWYMGCYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFH 224
           GY P    P I WY     +++ N+ I  G  L+ +     + GNYT ++T P +     
Sbjct: 356 GYPP----PEIKWYKNGIPLES-NHTIKAGHVLTIMEVSERDTGNYTVILTNPISKEKQS 410

Query: 225 LTRTLTVKVVGSPKNAVPPVIHSPNDHVVYEKEPGEELLIPCTVY 269
              +L V V   P       + SP D   Y    G    + CTVY
Sbjct: 411 HVVSLVVYV---PPQIGEKSLISPVDSYQY----GTTQTLTCTVY 448


>gi|119220552 sidekick 1 [Homo sapiens]
          Length = 2213

 Score = 33.5 bits (75), Expect = 0.30
 Identities = 28/89 (31%), Positives = 37/89 (41%), Gaps = 18/89 (20%)

Query: 172 KPTITWYM-------GCYKIQNFNNVIPEGMNLSFLIALISNNGNYTCVVTYPENGRTFH 224
           KP ITW         G  +I  F  ++ E   L      I + GNYTC     E   + +
Sbjct: 508 KPAITWKRENHILASGSVRIPRF--MLLESGGLQIAPVFIQDAGNYTCYAANTEG--SLN 563

Query: 225 LTRTLTVKVVGSPKNAVPPVIHSPNDHVV 253
            + TLTV    S       ++H P DHVV
Sbjct: 564 ASATLTVWNRTS-------IVHPPEDHVV 585



 Score = 29.6 bits (65), Expect = 4.3
 Identities = 20/70 (28%), Positives = 29/70 (41%), Gaps = 2/70 (2%)

Query: 72  WTRQDRDLEEPINFRLPENRISKEKDVLWFRPTLLNDTGNYTCMLRNTTYCSKVAFPLEV 131
           W R++  L    + R+P   +  E   L   P  + D GNYTC   NT      +  L V
Sbjct: 513 WKRENHILASG-SVRIPRFMLL-ESGGLQIAPVFIQDAGNYTCYAANTEGSLNASATLTV 570

Query: 132 VQKDSCFNSP 141
             + S  + P
Sbjct: 571 WNRTSIVHPP 580


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.136    0.431 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 14,278,502
Number of Sequences: 37866
Number of extensions: 665916
Number of successful extensions: 1893
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 29
Number of HSP's successfully gapped in prelim test: 69
Number of HSP's that attempted gapping in prelim test: 1586
Number of HSP's gapped (non-prelim): 344
length of query: 356
length of database: 18,247,518
effective HSP length: 103
effective length of query: 253
effective length of database: 14,347,320
effective search space: 3629871960
effective search space used: 3629871960
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.