Search of human proteins with 198041928

Search of human proteins with 198041928

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo
sapiens]
         (766 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]  1543   0.0  
gi|24797153 faciogenital dysplasia protein [Homo sapiens]             644   0.0  
gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]   595   e-170
gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]   506   e-143
gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]   506   e-143
gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]   301   2e-81
gi|194018497 FYVE, RhoGEF and PH domain containing 5 [Homo sapiens]   236   6e-62
gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo sa...   182   1e-45
gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform...   165   1e-40
gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R...   111   3e-24
gi|21735572 epithelial cell transforming sequence 2 oncogene pro...   102   2e-21
gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]          100   9e-21
gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]          100   9e-21
gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a [...   100   9e-21
gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b [...   100   9e-21
gi|166197690 neuronal guanine nucleotide exchange factor isoform...    97   6e-20
gi|166197688 neuronal guanine nucleotide exchange factor isoform...    97   6e-20
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]                96   2e-19
gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Hom...    94   6e-19
gi|164565408 common-site lymphoma/leukemia guanine nucleotide ex...    92   2e-18
gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]             92   2e-18
gi|23308553 spermatogenesis associated 13 [Homo sapiens]               91   5e-18
gi|45439359 triple functional domain (PTPRF interacting) [Homo s...    90   7e-18
gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]           89   2e-17
gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]            89   2e-17
gi|13375827 phafin 2 [Homo sapiens]                                    89   2e-17
gi|194473700 Src homology 3 domain-containing guanine nucleotide...    87   4e-17
gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]              86   1e-16
gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]             85   2e-16
gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like...    84   5e-16

>gi|198041928 FYVE, RhoGEF and PH domain containing 4 [Homo sapiens]
          Length = 766

 Score = 1543 bits (3996), Expect = 0.0
 Identities = 766/766 (100%), Positives = 766/766 (100%)

Query: 1   MEEIKPASASCVSKEKPSKVSDLISRFEGGSSLSNYSDLKKESAVNLNAPRTPGRHGLTT 60
           MEEIKPASASCVSKEKPSKVSDLISRFEGGSSLSNYSDLKKESAVNLNAPRTPGRHGLTT
Sbjct: 1   MEEIKPASASCVSKEKPSKVSDLISRFEGGSSLSNYSDLKKESAVNLNAPRTPGRHGLTT 60

Query: 61  TPQQKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASE 120
           TPQQKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASE
Sbjct: 61  TPQQKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASE 120

Query: 121 PLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQE 180
           PLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQE
Sbjct: 121 PLLDTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEERGAETETKVQE 180

Query: 181 RENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEA 240
           RENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEA
Sbjct: 181 RENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEA 240

Query: 241 NRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYG 300
           NRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYG
Sbjct: 241 NRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYG 300

Query: 301 EYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLK 360
           EYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLK
Sbjct: 301 EYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLK 360

Query: 361 DYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPS 420
           DYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPS
Sbjct: 361 DYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPS 420

Query: 421 NELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVE 480
           NELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVE
Sbjct: 421 NELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVE 480

Query: 481 TQNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDI 540
           TQNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDI
Sbjct: 481 TQNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDI 540

Query: 541 HSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQL 600
           HSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQL
Sbjct: 541 HSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQL 600

Query: 601 EYDGGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQ 660
           EYDGGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQ
Sbjct: 601 EYDGGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQ 660

Query: 661 KAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSF 720
           KAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSF
Sbjct: 661 KAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSF 720

Query: 721 AADSEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC 766
           AADSEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC
Sbjct: 721 AADSEELKQKWLKVILLAVTGETPGGPNEHPATLDDHPEPKKKSEC 766


>gi|24797153 faciogenital dysplasia protein [Homo sapiens]
          Length = 961

 Score =  644 bits (1660), Expect = 0.0
 Identities = 324/602 (53%), Positives = 436/602 (72%), Gaps = 16/602 (2%)

Query: 173 ETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVF 232
           E E   +E E  +  + +  +++   ++ T +QK+  IANELL TE+AYV+RL LLDQVF
Sbjct: 340 EEEDDEEEEEEKDREIPVPLMERQESVELTVQQKVFHIANELLQTEKAYVSRLHLLDQVF 399

Query: 233 YCKLLEEA-NRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQK 291
             +LLEEA NR SFPA++V+ IFSNI SI  FH +FLLPELEKRM+EW+  PRIGDILQK
Sbjct: 400 CARLLEEARNRSSFPADVVHGIFSNICSIYCFHQQFLLPELEKRMEEWDRYPRIGDILQK 459

Query: 292 LAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQR 351
           LAPFLKMYGEYVK FD A+ELV   TER  QFK ++ E+QK++ CG+LTLQHHMLEPVQR
Sbjct: 460 LAPFLKMYGEYVKNFDRAVELVNTWTERSTQFKVIIHEVQKEEACGNLTLQHHMLEPVQR 519

Query: 352 IPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLG 411
           IPRYE+LLKDYL KLP  S D  DA+KSLE+I+TAA HSN+AIRKME + KLL++YE+LG
Sbjct: 520 IPRYELLLKDYLLKLPHGSPDSKDAQKSLELIATAAEHSNAAIRKMERMHKLLKVYELLG 579

Query: 412 EEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRV 471
            EEDIV+P+ ELIKEG ILKL+A+N + Q+RYL LFN+ LLYCVP+  L+G KF+VR R+
Sbjct: 580 GEEDIVSPTKELIKEGHILKLSAKNGTTQDRYLILFNDRLLYCVPRLRLLGQKFSVRARI 639

Query: 472 GIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFR 531
            +DGM++ E+ N   P TF VSGK+R+LELQA + ++K++W++A+  T+    Q  ETF+
Sbjct: 640 DVDGMELKESSNLNLPRTFLVSGKQRSLELQARTEEEKKDWVQAINSTLLKHEQTLETFK 699

Query: 532 ---NAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYV 588
              +   +D D        +LGKRAP  IR+ EVTMCM+C+EPFN++T+RRHHC+ACG+V
Sbjct: 700 LLNSTNREDEDTPPNSPNVDLGKRAPTPIREKEVTMCMRCQEPFNSITKRRHHCKACGHV 759

Query: 589 VCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSE-------EKKRKGILEIESAEVS 641
           VC KCS+++A+L YD  + ++VC DCY  + G   S         ++R+ ILE +++  +
Sbjct: 760 VCGKCSEFRARLVYDNNRSNRVCTDCYVALHGVPGSSPACSQHTPQRRRSILEKQASVAA 819

Query: 642 GNSVVCSFLQYMEK-SKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVV--DE 698
            NSV+CSFL YMEK  K W KAW V+P+ +PLVLY+YGAPQDV+AQ ++PL+G+ V   E
Sbjct: 820 ENSVICSFLHYMEKGGKGWHKAWFVVPENEPLVLYIYGAPQDVKAQRSLPLIGFEVGPPE 879

Query: 699 MPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTGET--PGGPNEHPATLDD 756
                D  H FK+TQS     F+ ++EEL+++W+ V+  A  G+T  PG        +++
Sbjct: 880 AGERPDRRHVFKITQSHLSWYFSPETEELQRRWMAVLGRAGRGDTFCPGPTLSEDREMEE 939

Query: 757 HP 758
            P
Sbjct: 940 AP 941


>gi|189217917 FYVE, RhoGEF and PH domain containing 2 [Homo sapiens]
          Length = 655

 Score =  595 bits (1533), Expect = e-170
 Identities = 296/548 (54%), Positives = 399/548 (72%), Gaps = 9/548 (1%)

Query: 209 KIANELLLTERAYVNRLDLLDQVFYCKLLEEANRG-SFPAEMVNKIFSNISSINAFHSKF 267
           KI  ELL TE+AYV RL LLDQVF+ +LL+ A    +FP ++V  IFSNISSI  FHS+F
Sbjct: 105 KIVQELLETEQAYVARLHLLDQVFFQELLKTARSSKAFPEDVVRVIFSNISSIYQFHSQF 164

Query: 268 LLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVV 327
            LPEL++R+ +W   PRIGD++QKLAPFLKMY EYVK F+ A EL+   T++ P F+ V+
Sbjct: 165 FLPELQRRLDDWTANPRIGDVIQKLAPFLKMYSEYVKNFERAAELLATWTDKSPLFQEVL 224

Query: 328 EEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAA 387
             IQ  +  GSLTLQHHMLEPVQRIPRYE+LLK+Y++KLP  + D  DA+K+L++I +AA
Sbjct: 225 TRIQSSEASGSLTLQHHMLEPVQRIPRYELLLKEYIQKLPAQAPDQADAQKALDMIFSAA 284

Query: 388 SHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLF 447
            HSN+AI +ME L+ L E+Y+ LG E+DIV+PSN L++EG +LK++ R     ERYLFLF
Sbjct: 285 QHSNAAITEMERLQDLWEVYQRLGLEDDIVDPSNTLLREGPVLKISFRRNDPMERYLFLF 344

Query: 448 NNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQ 507
           NNMLLYCVP+   VG++F VRTR+ + GMK+ E  + E+PH+F VSGK+RTLELQA S +
Sbjct: 345 NNMLLYCVPRVIQVGAQFQVRTRIDVAGMKVRELMDAEFPHSFLVSGKQRTLELQARSQE 404

Query: 508 DKEEWIKALQETIDAFHQRHETFRNAI-AKDNDI-HSEVSTAELGKRAPRWIRDNEVTMC 565
           +   W++A Q  ID   +R+ETF+ A    + DI   E+ + ELG RAP+W+RD  VTMC
Sbjct: 405 EMISWMQAFQAAIDQIEKRNETFKAAAQGPEGDIQEQELQSEELGLRAPQWVRDKMVTMC 464

Query: 566 MKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISG--FTD 623
           M+C+EPFNALTRRRHHCRACGYVVC +CSDY+A+L+YD  + ++VC  CY  ++G    +
Sbjct: 465 MRCQEPFNALTRRRHHCRACGYVVCARCSDYRAELKYDDNRPNRVCLHCYAFLTGNVLPE 524

Query: 624 SEEKKRKGILEIESAEVSGNSVVCSFLQYM--EKSKPWQKAWCVIPKQDPLVLYMYGAPQ 681
           ++E KR+GILE  S+     S++CSFLQ +  +  K   + WCVIP+ DPLVLY+Y APQ
Sbjct: 525 AKEDKRRGILEKGSSATPDQSLMCSFLQLIGDKWGKSGPRGWCVIPRDDPLVLYVYAAPQ 584

Query: 682 DVRAQATIPLLGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVTG 741
           D+RA  +IPLLGY V   P+    P  F+L QS  +++F A++EELK +W+K +  A +G
Sbjct: 585 DMRAHTSIPLLGYQVTVGPQGD--PRVFQLQQSGQLYTFKAETEELKGRWVKAMERAASG 642

Query: 742 ETPGGPNE 749
            +P  PN+
Sbjct: 643 WSPSWPND 650


>gi|134133248 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score =  506 bits (1303), Expect = e-143
 Identities = 278/608 (45%), Positives = 379/608 (62%), Gaps = 49/608 (8%)

Query: 164 VLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVN 223
           V P EE  ++   +       +   +   L QH     +  QKL  IA ELL TE  YV 
Sbjct: 120 VTPQEEADSDVGEEPDSENTPQKADKDAGLAQH-----SGPQKLLHIAQELLHTEETYVK 174

Query: 224 RLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRM-QEWETT 282
           RL LLDQVF  +L +       P E++  IFSNISSI+ FH +FLLPEL+ R+ +EW+T 
Sbjct: 175 RLHLLDQVFCTRLTD----AGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTN 230

Query: 283 PRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQ 342
           PR+GDILQKLAPFLKMYGEYVK FD A+ LV   T+R P FK VV  IQKQ++CG+LTLQ
Sbjct: 231 PRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQ 290

Query: 343 HHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKK 402
           HHMLEPVQR+PRYE+LLKDYL++LP D+ D  DA++SLE+ISTAA+HSN+AIRK+E + K
Sbjct: 291 HHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHK 350

Query: 403 LLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVG 462
           LLE+YE LG EEDIVNP+NELIKEGQI KL+A+N + Q+R+LFLFN+M+LYCVPK  L+G
Sbjct: 351 LLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMG 410

Query: 463 SKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDA 522
            KF+VR ++ I G+++ +       HTF ++G++R+LELQ  + ++K+EWI+ +Q TI+ 
Sbjct: 411 QKFSVREKMDISGLQVQDIVKPNTAHTFIITGRKRSLELQTRTEEEKKEWIQIIQATIEK 470

Query: 523 FHQRHETFR---NAIAKDND------------------IHSEVSTAELG----KRAPRWI 557
             Q  ETF+    A ++D D                  + +E S+   G    K + +  
Sbjct: 471 HKQNSETFKAFGGAFSQDEDPSLSPDMPITSTSPVEPVVTTEGSSGAAGLEPRKLSSKTR 530

Query: 558 RDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQI 617
           RD E   C  C E FN++T+RRHHC+ CG V+C KCS++KA    +  + S+VC+DC+  
Sbjct: 531 RDKEKQSCKSCGETFNSITKRRHHCKLCGAVICGKCSEFKA----ENSRQSRVCRDCFLT 586

Query: 618 ISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMY 677
                +S EK      +         S++C  L+  E  + W + W  IP  DP VL++ 
Sbjct: 587 QPVAPESTEKTPTADPQ--------PSLLCGPLRLSESGETWSEVWAAIPMSDPQVLHLQ 638

Query: 678 GAPQDVRAQATIPL--LGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVI 735
           G  QD R   TIPL      V +     D  H +KL  +K     +A S EL+Q+WL+ +
Sbjct: 639 GGSQDGRLPRTIPLPSCKLSVPDPEERLDSGHVWKLQWAKQSWYLSASSAELQQQWLETL 698

Query: 736 LLAVTGET 743
             A  G+T
Sbjct: 699 STAAHGDT 706


>gi|134133265 FYVE, RhoGEF and PH domain containing 3 [Homo sapiens]
          Length = 725

 Score =  506 bits (1303), Expect = e-143
 Identities = 278/608 (45%), Positives = 379/608 (62%), Gaps = 49/608 (8%)

Query: 164 VLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVN 223
           V P EE  ++   +       +   +   L QH     +  QKL  IA ELL TE  YV 
Sbjct: 120 VTPQEEADSDVGEEPDSENTPQKADKDAGLAQH-----SGPQKLLHIAQELLHTEETYVK 174

Query: 224 RLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRM-QEWETT 282
           RL LLDQVF  +L +       P E++  IFSNISSI+ FH +FLLPEL+ R+ +EW+T 
Sbjct: 175 RLHLLDQVFCTRLTD----AGIPPEVIMGIFSNISSIHRFHGQFLLPELKTRITEEWDTN 230

Query: 283 PRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQ 342
           PR+GDILQKLAPFLKMYGEYVK FD A+ LV   T+R P FK VV  IQKQ++CG+LTLQ
Sbjct: 231 PRLGDILQKLAPFLKMYGEYVKNFDRAVGLVSTWTQRSPLFKDVVHSIQKQEVCGNLTLQ 290

Query: 343 HHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKK 402
           HHMLEPVQR+PRYE+LLKDYL++LP D+ D  DA++SLE+ISTAA+HSN+AIRK+E + K
Sbjct: 291 HHMLEPVQRVPRYELLLKDYLKRLPQDAPDRKDAERSLELISTAANHSNAAIRKVEKMHK 350

Query: 403 LLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVG 462
           LLE+YE LG EEDIVNP+NELIKEGQI KL+A+N + Q+R+LFLFN+M+LYCVPK  L+G
Sbjct: 351 LLEVYEQLGGEEDIVNPANELIKEGQIQKLSAKNGTPQDRHLFLFNSMILYCVPKLRLMG 410

Query: 463 SKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDA 522
            KF+VR ++ I G+++ +       HTF ++G++R+LELQ  + ++K+EWI+ +Q TI+ 
Sbjct: 411 QKFSVREKMDISGLQVQDIVKPNTAHTFIITGRKRSLELQTRTEEEKKEWIQIIQATIEK 470

Query: 523 FHQRHETFR---NAIAKDND------------------IHSEVSTAELG----KRAPRWI 557
             Q  ETF+    A ++D D                  + +E S+   G    K + +  
Sbjct: 471 HKQNSETFKAFGGAFSQDEDPSLSPDMPITSTSPVEPVVTTEGSSGAAGLEPRKLSSKTR 530

Query: 558 RDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQI 617
           RD E   C  C E FN++T+RRHHC+ CG V+C KCS++KA    +  + S+VC+DC+  
Sbjct: 531 RDKEKQSCKSCGETFNSITKRRHHCKLCGAVICGKCSEFKA----ENSRQSRVCRDCFLT 586

Query: 618 ISGFTDSEEKKRKGILEIESAEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMY 677
                +S EK      +         S++C  L+  E  + W + W  IP  DP VL++ 
Sbjct: 587 QPVAPESTEKTPTADPQ--------PSLLCGPLRLSESGETWSEVWAAIPMSDPQVLHLQ 638

Query: 678 GAPQDVRAQATIPL--LGYVVDEMPRSADLPHSFKLTQSKSVHSFAADSEELKQKWLKVI 735
           G  QD R   TIPL      V +     D  H +KL  +K     +A S EL+Q+WL+ +
Sbjct: 639 GGSQDGRLPRTIPLPSCKLSVPDPEERLDSGHVWKLQWAKQSWYLSASSAELQQQWLETL 698

Query: 736 LLAVTGET 743
             A  G+T
Sbjct: 699 STAAHGDT 706


>gi|154240686 FYVE, RhoGEF and PH domain containing 6 [Homo sapiens]
          Length = 1430

 Score =  301 bits (770), Expect = 2e-81
 Identities = 200/631 (31%), Positives = 317/631 (50%), Gaps = 55/631 (8%)

Query: 142  PTTDSCDGNASDSSYRTPGIGPVLPLEER---GAETETKVQERENGE-SPLELEQLDQHH 197
            P        AS       G+G +   EE     ++ +    E   GE  PLE +Q D+ +
Sbjct: 808  PRHQHSSSGASQEEQNDLGLGDLPSDEEEIINSSDEDDVSSESSKGEPDPLEDKQ-DEDN 866

Query: 198  EMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPA---EMVNKIF 254
             MK     K+H IA E++ +E+ +V+ L LL   F   +   + +   P     ++N+I 
Sbjct: 867  GMKS----KVHHIAKEIMSSEKVFVDVLKLLHIDFRDAVAHASRQLGKPVIEDRILNQIL 922

Query: 255  SNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVK 314
              +  +   + + LL ELE+RM  W    RI DI  K  P+LKMY  Y+K FD  + L+ 
Sbjct: 923  YYLPQLYELN-RDLLKELEERMLHWTEQQRIADIFVKKGPYLKMYSTYIKEFDKNIALLD 981

Query: 315  NMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWN 374
               ++ P F +VV E +    C +L L+H++L+PVQRIP+Y +LL DYL+ L  D+ D+ 
Sbjct: 982  EQCKKNPGFAAVVREFEMSPRCANLALKHYLLKPVQRIPQYRLLLTDYLKNLIEDAGDYR 1041

Query: 375  DAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAA 434
            D + +L ++   A+H+N  +++ +N +KL++I   L    +IV P    +KEG ++KL+ 
Sbjct: 1042 DTQDALAVVIEVANHANDTMKQGDNFQKLMQIQYSLNGHHEIVQPGRVFLKEGILMKLSR 1101

Query: 435  RNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSG 494
            +    Q R  FLFN+ LLY  P   +    + +   + + GMK+ +   E Y +  ++  
Sbjct: 1102 K--VMQPRMFFLFNDALLYTTP---VQSGMYKLNNMLSLAGMKVRKPTQEAYQNELKIES 1156

Query: 495  KERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDN-DIHSEVSTAELGKRA 553
             ER+  L ASSA +++EW++A+   I+ + ++  TF  + + D  D  ++   + LG +A
Sbjct: 1157 VERSFILSASSATERDEWLEAISRAIEEYAKKRITFCPSRSLDEADSENKEEVSPLGSKA 1216

Query: 554  PRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKD 613
            P WI D   TMCM C   F  LT RRHHCRACG +VC  CS  K  L+Y   + ++VC+ 
Sbjct: 1217 PIWIPDTRATMCMICTSEF-TLTWRRHHCRACGKIVCQACSSNKYGLDYLKNQPARVCEH 1275

Query: 614  CYQIISGFTDSEEKKRKG---------------ILEIESA-----------EVSGNSVVC 647
            C+Q +    D +   R G               +  I S            EVS N+   
Sbjct: 1276 CFQELQKL-DHQHSPRIGSPGNHKSPSSALSSVLHSIPSGRKQKKIPAALKEVSANTEDS 1334

Query: 648  SFLQYMEKS----KPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSA 703
            S   Y+ +S    KPW+  W VI  +   VLY Y A +DV A  + PLLG+ V ++    
Sbjct: 1335 SMSGYLYRSKGNKKPWKHFWFVIKNK---VLYTYAASEDVAALESQPLLGFTVIQVKDEN 1391

Query: 704  DLPHSFKLTQSKSV-HSFAADSEELKQKWLK 733
                 F+L     + + F A+     QKW++
Sbjct: 1392 SESKVFQLLHKNMLFYVFKAEDAHSAQKWIE 1422


>gi|194018497 FYVE, RhoGEF and PH domain containing 5 [Homo sapiens]
          Length = 1462

 Score =  236 bits (602), Expect = 6e-62
 Identities = 169/636 (26%), Positives = 298/636 (46%), Gaps = 71/636 (11%)

Query: 150  NASDSSYRTPGIGPVLPLEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHK 209
            +A    Y+   I    P E+  ++ E +  E E+  S       D     K   + +   
Sbjct: 842  SAYTEPYKVCPISSAAPKEDLTSDEEQRSSEEEDSASR------DPSVTHKVEGQSRALV 895

Query: 210  IANELLLTERAYVNRLDLLDQVFYCKLL------EEANRGSFPAEMVNKIFSNISSINAF 263
            IA ELL +E+AYV  L  L+  F+  ++      +   R +   E + +  S + +I+  
Sbjct: 896  IAQELLSSEKAYVEMLQHLNLDFHGAVMRALDDMDHEGRDTLAREELRQGLSELPAIHDL 955

Query: 264  HSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQF 323
            H   +L ELE+R+  WE+  ++ D+          +  ++  FD  + L+       P+ 
Sbjct: 956  HQG-ILEELEERLSNWESQQKVADVFLAREQGFDHHATHILQFDRYLGLLSENCLHSPRL 1014

Query: 324  KSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEII 383
             + V E ++    GS T +H +L  VQR+ +Y++LL DYL  L PDS ++++ + +L +I
Sbjct: 1015 AAAVREFEQSVQGGSQTAKHRLLRVVQRLFQYQVLLTDYLNNLCPDSAEYDNTQGALSLI 1074

Query: 384  STAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERY 443
            S     +N ++ + ENL+KL+ I   +  + D++ P  E +KEG ++K+  +N   + R+
Sbjct: 1075 SKVTDRANDSMEQGENLQKLVHIEHSVRGQGDLLQPGREFLKEGTLMKVTGKN--RRPRH 1132

Query: 444  LFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERTLELQA 503
            LFL N++LLY  P+      K+ ++  + +  MK+     E+ P+  ++   E  L L A
Sbjct: 1133 LFLMNDVLLYTYPQ---KDGKYRLKNTLAVANMKVSRPVMEKVPYALKIETSESCLMLSA 1189

Query: 504  SSAQDKEEWIKALQETI--DAFHQRHETFRNAIAKDNDIHSEVSTAELGKRAPRWIRDNE 561
            SS  +++EW   L   +  D   Q    F +++    +I   +  + LG+R P  +    
Sbjct: 1190 SSCAERDEWYGCLSRALPEDYKAQALAAFHHSV----EIRERLGVS-LGERPPTLVPVTH 1244

Query: 562  VTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDC------- 614
            V MCM C   F +LT RRHHC ACG +VC  CS  K  L+Y   +++KVC  C       
Sbjct: 1245 VMMCMNCGCDF-SLTLRRHHCHACGKIVCRNCSRNKYPLKYLKDRMAKVCDGCFGELKKR 1303

Query: 615  --------------------------------YQIISGFTDSEEKKRKGILEIESAEVSG 642
                                            +Q I+  T  ++KK    L   +A   G
Sbjct: 1304 GRAVPGLMRERPVSMSFPLSSPRFSGSAFSSVFQSINPSTFKKQKKVPSALTEVAASGEG 1363

Query: 643  NSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVV--DEMP 700
            +++     +     + W+K W VI  +   VLY Y A +D  A  ++PLLG+ +  ++  
Sbjct: 1364 SAISGYLSRCKRGKRHWKKLWFVIKGK---VLYTYMASEDKVALESMPLLGFTIAPEKEE 1420

Query: 701  RSADLPHSFKLTQSKSV-HSFAADSEELKQKWLKVI 735
             S+++   F L   K++ +SF A+     Q+W++ +
Sbjct: 1421 GSSEVGPIFHLYHKKTLFYSFKAEDTNSAQRWIEAM 1456



 Score = 35.4 bits (80), Expect = 0.20
 Identities = 51/203 (25%), Positives = 73/203 (35%), Gaps = 34/203 (16%)

Query: 2   EEIKPASASCVSKEKPSKVSDLISRFEGGSSLSNYSDLKKESAVNLNAPRTPGRHGLTTT 61
           +E    + + VS E  ++  +   R EGG +         E +V   AP  PG   L+  
Sbjct: 80  DEGSVGNKALVSPESSAEEEE--EREEGGEACGLEGTGAGEDSV---APAAPGAGALSRE 134

Query: 62  PQQKLLSQHLPQRQGNDTDKTQGAQTCVANGVMAAQNQMECEEEKAATLSSDTSIQASEP 121
            ++           G D       + C        Q     EEEK      + S++ S P
Sbjct: 135 GEE-----------GTDLALEDEGEGCADEPGTLEQVSRSEEEEKLVQPHRECSLEDSGP 183

Query: 122 ----------LLDTHIVNGERDETATAPASPTTDSCDGNAS-DSSYRTPGIGPVLPLEER 170
                     LL  HI +GE  E    P     D  +G AS D +    G GP  P E+ 
Sbjct: 184 WAGEGVFQSDLLLPHI-HGEDQEPPDTPGEAEEDDEEGCASTDPAGADEGSGPDRPTEDM 242

Query: 171 GAETETKVQERENGESPLELEQL 193
           G + E      +  E P E E+L
Sbjct: 243 GQDAE------DTSEEPPEKEEL 259


>gi|7662310 FERM, RhoGEF and pleckstrin domain protein 2 [Homo
            sapiens]
          Length = 1054

 Score =  182 bits (461), Expect = 1e-45
 Identities = 167/611 (27%), Positives = 266/611 (43%), Gaps = 93/611 (15%)

Query: 182  ENGESPLELEQLDQHHEMKETNEQKLHK---------IANELLLTERAYVNRLDLLDQVF 232
            E G SPL    L          E+  HK         I  E+L TER Y+  L+++   F
Sbjct: 502  EQGSSPLLSPVLSDAGGAGMDCEEPRHKRVPADEAYFIVKEILATERTYLKDLEVITVWF 561

Query: 233  YCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWE---------TTP 283
               +++E    + PA ++  +FSNI  I  FH  FL  E+E+R+  WE         +  
Sbjct: 562  RSAVVKE---DAMPATLMTLLFSNIDPIYEFHRGFLR-EVEQRLALWEGPSKAHTKGSHQ 617

Query: 284  RIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQH 343
            RIGDIL +    LK +  Y +  D  +  ++  T+R  + ++V +E + QK+C  L L  
Sbjct: 618  RIGDILLRNMRQLKEFTSYFQRHDEVLTELEKATKRCKKLEAVYKEFELQKVC-YLPLNT 676

Query: 344  HMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKL 403
             +L+P+QR+  Y +LL+       P   D+ D   +L+ I+   +     + ++ENL+KL
Sbjct: 677  FLLKPIQRLLHYRLLLRRLCGHYSPGHHDYADCHDALKAITEVTTTLQHILIRLENLQKL 736

Query: 404  LEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGS 463
             E+   L   E+++ P  E I+EG + KL  +    Q+R  FLF++MLLY   K     S
Sbjct: 737  TELQRDLVGIENLIAPGREFIREGCLHKLTKK--GLQQRMFFLFSDMLLY-TSKGVAGTS 793

Query: 464  KFTVRTRVGIDGMKIVETQNE-EYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDA 522
             F +R  + + GM + E+ NE   PH F +   ++T+ + AS+  +KE+W+  L   I A
Sbjct: 794  HFRIRGLLPLQGMLVEESDNEWSVPHCFTIYAAQKTIVVAASTRLEKEKWMLDLNSAIQA 853

Query: 523  FHQRHETF-----RNAIAKDNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTR 577
                 +T      R    +     +EVS  +  +   R +R              ++L  
Sbjct: 854  AKSGGDTAPALPGRTVCTRPPRSPNEVSLEQESEDDARGVR--------------SSLEG 899

Query: 578  RRHHCRACGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRKGILEIES 637
               H       VCW          Y    +S+         +  + + E +  G L    
Sbjct: 900  HGQHRANTTMHVCW----------YRNTSVSR---------ADHSAAVENQLSGYL---- 936

Query: 638  AEVSGNSVVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVD 697
                        L+  + S  WQK W V        L+ Y   QD    A++PLLGY V 
Sbjct: 937  ------------LRKFKNSHGWQKLWVVFTN---FCLFFYKTHQDDYPLASLPLLGYSV- 980

Query: 698  EMPRSADLPHS---FKLTQSKSVHSFAADSEELKQKWLKVILLAVTGETPGGPNEHPATL 754
             +PR AD  H    FKL     V+ F A+S+   ++W++VI  A            P+ +
Sbjct: 981  SIPREADGIHKDYVFKLQFKSHVYFFRAESKYTFERWMEVIQGA-----SSSAGRAPSIV 1035

Query: 755  DDHPEPKKKSE 765
             D P+P    E
Sbjct: 1036 QDGPQPSSGLE 1046


>gi|5031633 FERM, RhoGEF, and pleckstrin domain protein 1 isoform 1
            [Homo sapiens]
          Length = 1045

 Score =  165 bits (418), Expect = 1e-40
 Identities = 152/638 (23%), Positives = 278/638 (43%), Gaps = 80/638 (12%)

Query: 124  DTHIVNGERDETATAPASPTTDSCDGNASDSSYRTPGIGPVLPLEER-GAETETKVQERE 182
            +  +V     ++   P  P+T S  G+   S       G V P             ++  
Sbjct: 451  EEEVVKDRTQQSKPQPPQPSTGSLTGSPHLSELSVNSQGGVAPANVTLSPNLSPDTKQAS 510

Query: 183  NGESPLELEQL------DQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKL 236
               SPL  +Q       +     K     K + IA E+  TER Y+  L+++   F   +
Sbjct: 511  PLISPLLNDQACPRTDDEDEGRRKRFPTDKAYFIAKEVSTTERTYLKDLEVITSWFQSTV 570

Query: 237  LEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTP--------RIGDI 288
             +E    + P  + + IF N   ++ FH+ FL  E+E+R+  WE           RIGD+
Sbjct: 571  SKE---DAMPEALKSLIFPNFEPLHKFHTNFL-KEIEQRLALWEGRSNAQIRDYQRIGDV 626

Query: 289  LQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEP 348
            + K    +K    ++     A+E ++N  +   + ++   + + QK+C  L L   +L P
Sbjct: 627  MLKNIQGMKHLAAHLWKHSEALEALENGIKSSRRLENFCRDFELQKVC-YLPLNTFLLRP 685

Query: 349  VQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYE 408
            + R+  Y+ +L+   +  PP   D+ D + +L  I+   +  +  + KMEN +KL E+ +
Sbjct: 686  LHRLMHYKQVLERLCKHHPPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHELKK 745

Query: 409  MLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVR 468
             L   +++V P  E I+ G + KL+ +    Q+R  FLFN++LLY   +     ++F V 
Sbjct: 746  DLIGIDNLVVPGREFIRLGSLSKLSGK--GLQQRMFFLFNDVLLY-TSRGLTASNQFKVH 802

Query: 469  TRVGIDGMKIVETQNE-EYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRH 527
             ++ + GM I E+++E   PH   + G+ +++ + ASS  + E+W++ +Q  ID   +  
Sbjct: 803  GQLPLYGMTIEESEDEWGVPHCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAIDLAEKSS 862

Query: 528  ETFRNAIAK---DNDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRA 584
                  +A    DN    E + A+         +++E  +         +L R+  H   
Sbjct: 863  SPAPEFLASSPPDNKSPDEATAAD---------QESEDDL----SASRTSLERQAPHRGN 909

Query: 585  CGYVVCWKCSDYKAQLEYDGGKLSKVCKDCYQIISGFTDSEEKKRKGILEIESAEVSGNS 644
                VCW  +   + +++                              + +E+ ++SGN 
Sbjct: 910  TMVHVCWHRNTSVSMVDFS-----------------------------IAVEN-QLSGN- 938

Query: 645  VVCSFLQYMEKSKPWQKAWCVIPKQDPLVLYMYGAPQDVRAQATIPLLGYVVDEMPRSAD 704
                 L+  + S  WQK W V        L+ Y + QD    A++PLLGY +     S +
Sbjct: 939  ----LLRKFKNSNGWQKLWVVFTN---FCLFFYKSHQDNHPLASLPLLGYSLTIPSESEN 991

Query: 705  L--PHSFKLTQSKSVHSFAADSEELKQKWLKVILLAVT 740
            +   + FKL     V+ F A+SE   ++W++VI  A +
Sbjct: 992  IQKDYVFKLHFKSHVYYFRAESEYTFERWMEVIRSATS 1029


>gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac
           exchange factor 1 [Homo sapiens]
          Length = 1659

 Score =  111 bits (277), Expect = 3e-24
 Identities = 92/386 (23%), Positives = 181/386 (46%), Gaps = 42/386 (10%)

Query: 210 IANELLLTERAYVNRLDLLDQVFYCKLLE---EANRGSFPAEMVNKIFSNISSINAFHSK 266
           + NE+L TER YV  L  L   F  ++ +   ++       E V  +FSNI  I   H  
Sbjct: 53  VLNEILGTERDYVGTLRFLQSAFLHRIRQNVADSVEKGLTEENVKVLFSNIEDILEVHKD 112

Query: 267 FLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSV 326
           FL         E ++   +G++  K      +Y EY    + A+ L+  +  +IP  ++ 
Sbjct: 113 FLAALEYCLHPEPQSQHELGNVFLKFKDKFCVYEEYCSNHEKALRLLVELN-KIPTVRAF 171

Query: 327 VEE--IQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIIS 384
           +    +   +    + L+ ++L P+QRI +Y +LLK+  ++ P    D    + +L+ + 
Sbjct: 172 LLSCMLLGGRKTTDIPLEGYLLSPIQRICKYPLLLKELAKRTPGKHPDHPAVQSALQAMK 231

Query: 385 TAASHSNSAIRKMENLKKLLEIYEML--GEEEDIVNPSNELIKEGQILKLAARNTSAQER 442
           T  S+ N   R+ME L+ L ++   +   E  ++ +   +L+ +G +LK++A N   QER
Sbjct: 232 TVCSNINETKRQMEKLEALEQLQSHIEGWEGSNLTDICTQLLLQGTLLKISAGN--IQER 289

Query: 443 YLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDG----------MKIVETQNEE------Y 486
             FLF+N+L+YC  K  + GSK + +    I+G           +++E +N E      +
Sbjct: 290 AFFLFDNLLVYCKRKSRVTGSKKSTKRTKSINGSLYIFRGRINTEVMEVENVEDGTADYH 349

Query: 487 PHTFQV--------SGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDN 538
            + + V        + K +     A +A++K++W+ A+        ++ E+ +  + +D 
Sbjct: 350 SNGYTVTNGWKIHNTAKNKWFVCMAKTAEEKQKWLDAIIRE----REQRESLKLGMERD- 404

Query: 539 DIHSEVSTAELGKRAPRWIRDNEVTM 564
              + V  AE G++    + + +V +
Sbjct: 405 ---AYVMIAEKGEKLYHMMMNKKVNL 427


>gi|21735572 epithelial cell transforming sequence 2 oncogene
           protein [Homo sapiens]
          Length = 883

 Score =  102 bits (253), Expect = 2e-21
 Identities = 74/285 (25%), Positives = 137/285 (48%), Gaps = 6/285 (2%)

Query: 184 GESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRG 243
           G++P    +  +      + +    ++A EL  TE  YVN L  + Q+F   L EE  RG
Sbjct: 399 GDTPKSCTKSSKSSTPVPSKQSARWQVAKELYQTESNYVNILATIIQLFQVPLEEEGQRG 458

Query: 244 S--FPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFL-KMYG 300
                 E +  IF +I  I   H+K +  +LE  +  W+ +  IGDI  K +  L K Y 
Sbjct: 459 GPILAPEEIKTIFGSIPDIFDVHTK-IKDDLEDLIVNWDESKSIGDIFLKYSKDLVKTYP 517

Query: 301 EYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLK 360
            +V  F+ + E +    ++ P+F + ++  Q +  CG  +L   ++ PVQR+P   +LL 
Sbjct: 518 PFVNFFEMSKETIIKCEKQKPRFHAFLKINQAKPECGRQSLVELLIRPVQRLPSVALLLN 577

Query: 361 DYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLE-IYEMLGEEEDIVNP 419
           D  +    ++ D +  +K++  +    +H N   RK E  K++ + +YE+ G   ++++ 
Sbjct: 578 DLKKHTADENPDKSTLEKAIGSLKEVMTHINEDKRKTEAQKQIFDVVYEVDGCPANLLSS 637

Query: 420 SNELIKEGQILKLAARNTSAQERY-LFLFNNMLLYCVPKFSLVGS 463
              L++  + + L        E+  LFLFN+ L     +  ++G+
Sbjct: 638 HRSLVQRVETISLGEHPCDRGEQVTLFLFNDCLEIARKRHKVIGT 682


>gi|47578117 DEP domain containing 2 isoform b [Homo sapiens]
          Length = 979

 Score = 99.8 bits (247), Expect = 9e-21
 Identities = 82/336 (24%), Positives = 154/336 (45%), Gaps = 35/336 (10%)

Query: 210 IANELLLTERAYVNRLDLLDQVFYCKLLEEANRG---SFPAEMVNKIFSNISSINAFHSK 266
           + +EL  TER YV  L+ L   F  ++ + A      +   E V  +FSNI  I A H +
Sbjct: 27  VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86

Query: 267 FLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSV 326
           FL    E    E      +G          ++Y EY    + A +L+  + +     +++
Sbjct: 87  FLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNK----IRTI 142

Query: 327 VEEIQKQKICGS-----LTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLE 381
              +    + G      + L+ +++ P+QRI +Y ++LK+ L++ P    D+    ++L+
Sbjct: 143 RTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQ 202

Query: 382 IISTAASHSNSAIRKMENLKKLLEIYEML--GEEEDIVNPSNELIKEGQILKLAARNTSA 439
            +    S+ N A R+ME L+ L E    +   E  +I +   E++  G +LK+++ N   
Sbjct: 203 AMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGN--I 260

Query: 440 QERYLFLFNNMLLYCV--------PKFSLVGSKFTVRTRVGIDGMKI--VETQNEEYPHT 489
           QER  FLF+N+L+YC          K S  G ++  R R+  + M++  V+    ++  +
Sbjct: 261 QERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSS 320

Query: 490 FQV---------SGKERTLELQASSAQDKEEWIKAL 516
             +         + K +     A + ++K EW +A+
Sbjct: 321 GHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAI 356


>gi|47578115 DEP domain containing 2 isoform a [Homo sapiens]
          Length = 1606

 Score = 99.8 bits (247), Expect = 9e-21
 Identities = 82/336 (24%), Positives = 154/336 (45%), Gaps = 35/336 (10%)

Query: 210 IANELLLTERAYVNRLDLLDQVFYCKLLEEANRG---SFPAEMVNKIFSNISSINAFHSK 266
           + +EL  TER YV  L+ L   F  ++ + A      +   E V  +FSNI  I A H +
Sbjct: 27  VLSELQKTERDYVGTLEFLVSAFLHRMNQCAASKVDKNVTEETVKMLFSNIEDILAVHKE 86

Query: 267 FLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSV 326
           FL    E    E      +G          ++Y EY    + A +L+  + +     +++
Sbjct: 87  FLKVVEECLHPEPNAQQEVGTCFLHFKDKFRIYDEYCSNHEKAQKLLLELNK----IRTI 142

Query: 327 VEEIQKQKICGS-----LTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLE 381
              +    + G      + L+ +++ P+QRI +Y ++LK+ L++ P    D+    ++L+
Sbjct: 143 RTFLLNCMLLGGRKNTDVPLEGYLVTPIQRICKYPLILKELLKRTPRKHSDYAAVMEALQ 202

Query: 382 IISTAASHSNSAIRKMENLKKLLEIYEML--GEEEDIVNPSNELIKEGQILKLAARNTSA 439
            +    S+ N A R+ME L+ L E    +   E  +I +   E++  G +LK+++ N   
Sbjct: 203 AMKAVCSNINEAKRQMEKLEVLEEWQSHIEGWEGSNITDTCTEMLMCGVLLKISSGN--I 260

Query: 440 QERYLFLFNNMLLYCV--------PKFSLVGSKFTVRTRVGIDGMKI--VETQNEEYPHT 489
           QER  FLF+N+L+YC          K S  G ++  R R+  + M++  V+    ++  +
Sbjct: 261 QERVFFLFDNLLVYCKRKHRRLKNSKASTDGHRYLFRGRINTEVMEVENVDDGTADFHSS 320

Query: 490 FQV---------SGKERTLELQASSAQDKEEWIKAL 516
             +         + K +     A + ++K EW +A+
Sbjct: 321 GHIVVNGWKIHNTAKNKWFVCMAKTPEEKHEWFEAI 356


>gi|15011979 Rho guanine nucleotide exchange factor 4 isoform a
           [Homo sapiens]
          Length = 690

 Score = 99.8 bits (247), Expect = 9e-21
 Identities = 80/353 (22%), Positives = 155/353 (43%), Gaps = 35/353 (9%)

Query: 198 EMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNI 257
           E + + +Q    + NE+L TER Y+  L  + + +  +  + A+   F  E +  IF NI
Sbjct: 276 EAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADM--FSEEQLRTIFGNI 333

Query: 258 SSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMT 317
             I      F+    ++  +E      +G    +     ++Y EY     NA   +  +T
Sbjct: 334 EDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLT 393

Query: 318 ERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAK 377
            ++ ++    E  +  +    ++L   +L PVQ+I +Y + L + L+   P   D+ D +
Sbjct: 394 -KLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVE 452

Query: 378 KSLEIISTAASHSNSAIRKMENLKKLLEIYEMLG--EEEDIVNPSNELIKEGQILKLAAR 435
            +L  +   A   N   R++EN+ K+ +    +   E ED++  S+ELI  G++ ++   
Sbjct: 453 AALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQP 512

Query: 436 NTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGK 495
              +Q+R  FLF++ L+YC  K  L       + R+ +DG+++V+ ++          GK
Sbjct: 513 QAKSQQRMFFLFDHQLIYC-KKDLLRRDVLYYKGRLDMDGLEVVDLED----------GK 561

Query: 496 ERTLELQASSA-------------------QDKEEWIKALQETIDAFHQRHET 529
           +R L +   +A                   + K+ W+KA     +      ET
Sbjct: 562 DRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQET 614


>gi|15011981 Rho guanine nucleotide exchange factor 4 isoform b
           [Homo sapiens]
          Length = 670

 Score = 99.8 bits (247), Expect = 9e-21
 Identities = 80/353 (22%), Positives = 155/353 (43%), Gaps = 35/353 (9%)

Query: 198 EMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNI 257
           E + + +Q    + NE+L TER Y+  L  + + +  +  + A+   F  E +  IF NI
Sbjct: 276 EAQSSKDQMRTNVINEILSTERDYIKHLRDICEGYVRQCRKRADM--FSEEQLRTIFGNI 333

Query: 258 SSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMT 317
             I      F+    ++  +E      +G    +     ++Y EY     NA   +  +T
Sbjct: 334 EDIYRCQKAFVKALEQRFNRERPHLSELGACFLEHQADFQIYSEYCNNHPNACVELSRLT 393

Query: 318 ERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAK 377
            ++ ++    E  +  +    ++L   +L PVQ+I +Y + L + L+   P   D+ D +
Sbjct: 394 -KLSKYVYFFEACRLLQKMIDISLDGFLLTPVQKICKYPLQLAELLKYTHPQHRDFKDVE 452

Query: 378 KSLEIISTAASHSNSAIRKMENLKKLLEIYEMLG--EEEDIVNPSNELIKEGQILKLAAR 435
            +L  +   A   N   R++EN+ K+ +    +   E ED++  S+ELI  G++ ++   
Sbjct: 453 AALHAMKNVAQLINERKRRLENIDKIAQWQSSIEDWEGEDLLVRSSELIYSGELTRVTQP 512

Query: 436 NTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGK 495
              +Q+R  FLF++ L+YC  K  L       + R+ +DG+++V+ ++          GK
Sbjct: 513 QAKSQQRMFFLFDHQLIYC-KKDLLRRDVLYYKGRLDMDGLEVVDLED----------GK 561

Query: 496 ERTLELQASSA-------------------QDKEEWIKALQETIDAFHQRHET 529
           +R L +   +A                   + K+ W+KA     +      ET
Sbjct: 562 DRDLHVSIKNAFRLHRGATGDSHLLCTRKPEQKQRWLKAFAREREQVQLDQET 614


>gi|166197690 neuronal guanine nucleotide exchange factor isoform 2
           [Homo sapiens]
          Length = 618

 Score = 97.1 bits (240), Expect = 6e-20
 Identities = 100/398 (25%), Positives = 176/398 (44%), Gaps = 57/398 (14%)

Query: 166 PLEERGAETETKVQERENGESPLELEQLDQ-------HH-----------------EMKE 201
           P  E   E E + +E E   SP E + L Q       H                  E+ +
Sbjct: 117 PASEDTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQ 176

Query: 202 TNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSIN 261
             E KL +   EL+ +E +Y   L+LL   F     E   +   P+E  + +FSN+  + 
Sbjct: 177 PEEIKLQEAMFELVTSEASYYKSLNLLVSHFMEN--ERIRKILHPSE-AHILFSNVLDVL 233

Query: 262 AFHSKFLLPELEKRMQEWETTPRIGDILQKLAP-FLKMYGEYVKGFDNAMELVKNMTERI 320
           A   +FLL ELE RM+E      + DI+ + A     +Y  YV          K + +  
Sbjct: 234 AVSERFLL-ELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEK 292

Query: 321 PQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDS---LDWNDAK 377
             F+ ++ +++    C  L     ++ P QRI R ++L+++ L+++   S       DA 
Sbjct: 293 AAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALDAH 352

Query: 378 KSLEIISTAASHSNSAIRKMENLKKLLEIYEMLG---EEEDIVNPSNELIKEGQILKLAA 434
           K LE++  A    N  +RKM   ++++ I + +    +   I++ S  L+K+G++ +++ 
Sbjct: 353 KELEMVVKAC---NEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSG 409

Query: 435 RNTSA--------QERYLFLFNNMLLYCVPKFSLVGSKFTVRTRV--GIDGMKIVETQNE 484
             TS          E YLFLFN++L+ C     + G K+ V      G+  ++ +E Q +
Sbjct: 410 PKTSRTLRTKKLFHEIYLFLFNDLLVIC---RQIPGDKYQVFDSAPRGLLRVEELEDQGQ 466

Query: 485 EYPHTF------QVSGKERTLELQASSAQDKEEWIKAL 516
              + F          +E T  L+ASS  + + W+ +L
Sbjct: 467 TLANVFILRLLENADDREATYMLKASSQSEMKRWMTSL 504


>gi|166197688 neuronal guanine nucleotide exchange factor isoform 1
           [Homo sapiens]
          Length = 710

 Score = 97.1 bits (240), Expect = 6e-20
 Identities = 100/398 (25%), Positives = 176/398 (44%), Gaps = 57/398 (14%)

Query: 166 PLEERGAETETKVQERENGESPLELEQLDQ-------HH-----------------EMKE 201
           P  E   E E + +E E   SP E + L Q       H                  E+ +
Sbjct: 209 PASEDTPEEEEEEEEEEEPASPPERKTLPQICLLSNPHSRFNLWQDLPEIRSSGVLEILQ 268

Query: 202 TNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSIN 261
             E KL +   EL+ +E +Y   L+LL   F     E   +   P+E  + +FSN+  + 
Sbjct: 269 PEEIKLQEAMFELVTSEASYYKSLNLLVSHFMEN--ERIRKILHPSE-AHILFSNVLDVL 325

Query: 262 AFHSKFLLPELEKRMQEWETTPRIGDILQKLAP-FLKMYGEYVKGFDNAMELVKNMTERI 320
           A   +FLL ELE RM+E      + DI+ + A     +Y  YV          K + +  
Sbjct: 326 AVSERFLL-ELEHRMEENIVISDVCDIVYRYAADHFSVYITYVSNQTYQERTYKQLLQEK 384

Query: 321 PQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDS---LDWNDAK 377
             F+ ++ +++    C  L     ++ P QRI R ++L+++ L+++   S       DA 
Sbjct: 385 AAFRELIAQLELDPKCRGLPFSSFLILPFQRITRLKLLVQNILKRVEERSERECTALDAH 444

Query: 378 KSLEIISTAASHSNSAIRKMENLKKLLEIYEMLG---EEEDIVNPSNELIKEGQILKLAA 434
           K LE++  A    N  +RKM   ++++ I + +    +   I++ S  L+K+G++ +++ 
Sbjct: 445 KELEMVVKAC---NEGVRKMSRTEQMISIQKKMEFKIKSVPIISHSRWLLKQGELQQMSG 501

Query: 435 RNTSA--------QERYLFLFNNMLLYCVPKFSLVGSKFTVRTRV--GIDGMKIVETQNE 484
             TS          E YLFLFN++L+ C     + G K+ V      G+  ++ +E Q +
Sbjct: 502 PKTSRTLRTKKLFHEIYLFLFNDLLVIC---RQIPGDKYQVFDSAPRGLLRVEELEDQGQ 558

Query: 485 EYPHTF------QVSGKERTLELQASSAQDKEEWIKAL 516
              + F          +E T  L+ASS  + + W+ +L
Sbjct: 559 TLANVFILRLLENADDREATYMLKASSQSEMKRWMTSL 596


>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
          Length = 1721

 Score = 95.5 bits (236), Expect = 2e-19
 Identities = 86/353 (24%), Positives = 149/353 (42%), Gaps = 35/353 (9%)

Query: 198  EMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNI 257
            +M    E+K     +EL++TE  YVN L L+ ++F   L+E         + V  IF N 
Sbjct: 1229 DMLTPTERKRQGYIHELIVTEENYVNDLQLVTEIFQKPLMESE---LLTEKEVAMIFVNW 1285

Query: 258  SSINAFHSKFLLPELEKRMQEWETTP--RIGDILQKLAPFLKMYGEYVKGFDNAMELVKN 315
              +   + K L     ++    E  P   IGDIL    P ++ Y  +     N   L++ 
Sbjct: 1286 KELIMCNIKLLKALRVRKKMSGEKMPVKMIGDILSAQLPHMQPYIRFCSRQLNGAALIQQ 1345

Query: 316  MTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWND 375
             T+  P FK  V+ +     C  + L   +L+P+QR+ RY +++K+ L   P +  D + 
Sbjct: 1346 KTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKPMQRVTRYPLIIKNILENTPENHPDHSH 1405

Query: 376  AKKSLEIISTAASHSNSAIRKMENLKKLLEI---YEMLGEEEDIVNPS-------NELIK 425
             K +LE      S  N  +R+ EN  +L  I    +  G  E +V  S        + + 
Sbjct: 1406 LKHALEKAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLSEQLVFNSVTNCLGPRKFLH 1465

Query: 426  EGQILKLAARNTSAQERYLFLFNNMLLYC---------------VPKFSLVGSKFTVRTR 470
             G++ K      S +E Y FLFN+ LL                  PK +L    +     
Sbjct: 1466 SGKLYKA----KSNKELYGFLFNDFLLLTQITKPLGSSGTDKVFSPKSNLQYKMYKTPIF 1521

Query: 471  VGIDGMKIVETQNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAF 523
            +    +K+    + + P  F +S  +R   L+A S  ++  W++ ++   + +
Sbjct: 1522 LNEVLVKLPTDPSGDEP-IFHISHIDRVYTLRAESINERTAWVQKIKAASELY 1573


>gi|21361458 Rho guanine nucleotide exchange factor (GEF) 17 [Homo
            sapiens]
          Length = 2063

 Score = 93.6 bits (231), Expect = 6e-19
 Identities = 69/250 (27%), Positives = 119/250 (47%), Gaps = 10/250 (4%)

Query: 210  IANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLL 269
            +A  LL TE++YV  L  L Q +   L +  N       +V++IF  I  +   H +FL 
Sbjct: 1070 VAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFL- 1128

Query: 270  PELEKRMQEWETTPRIGDILQKLAP---FLKMYGEYVKGFDNAMELVKNMTERIPQFKSV 326
             ++   MQ W    ++G +L +       + +Y  Y+  F NA + V+   E  P F   
Sbjct: 1129 EQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKF 1188

Query: 327  VEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTA 386
            +E+  ++       L   M++PVQRIPRYE+L+KD L+  P D  D     ++   I   
Sbjct: 1189 LEQSMRENK-EKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQV 1247

Query: 387  ASHSNSAIRKMENLKK----LLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQER 442
            A   N  +R  E  ++    L EI   +   ED+  P    +++  ++++ A     ++R
Sbjct: 1248 AERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIG-GKKDR 1306

Query: 443  YLFLFNNMLL 452
             LFLF ++++
Sbjct: 1307 SLFLFTDLIV 1316


>gi|164565408 common-site lymphoma/leukemia guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 1386

 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 118/444 (26%), Positives = 191/444 (43%), Gaps = 44/444 (9%)

Query: 134 ETATAPASPTTDSCDGNASDSSYRTPGI-GPVLPLEERGAETETKVQERENGESPLELEQ 192
           ET TAPA+PT  S  G+ S +S  T G  G   P    G          E    P     
Sbjct: 33  ETRTAPAAPTMASPRGSGSSTSLSTVGSEGDPAP----GPTPACSASRPEPLPGPPIRLH 88

Query: 193 LDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNK 252
           L            +L ++A E++ TERAYV  L  + + +   LL+    G    E V  
Sbjct: 89  LSPVGIPGSARPSRLERVAREIVETERAYVRDLRSIVEDYLGPLLDGGVLG-LSVEQVGT 147

Query: 253 IFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMEL 312
           +F+NI  I  F S+ LL +LE       +   I +   + +    +Y  Y   + +++ L
Sbjct: 148 LFANIEDIYEFSSE-LLEDLENS----SSAGGIAECFVQRSEDFDIYTLYCMNYPSSLAL 202

Query: 313 VKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLP--PDS 370
           ++ ++   P    + E  ++ ++  SL LQ  +L+PVQRI +Y +LL++  +     P +
Sbjct: 203 LRELSLSPPAALWLQE--RQAQLRHSLPLQSFLLKPVQRILKYHLLLQELGKHWAEGPGT 260

Query: 371 LDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGE-EEDIVNPSNELIKEGQI 429
                 ++++  ++  A + N   RK E+  +L E+   LG      ++   EL+ EG  
Sbjct: 261 GGREMVEEAIVSMTAVAWYINDMKRKQEHAARLQEVQRRLGGWTGPELSAFGELVLEGAF 320

Query: 430 LKLAARNTSAQ--ERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKIVETQNEEYP 487
                     +  ER LFLF+ MLL    +    G ++T +  +    + + E+  +  P
Sbjct: 321 RGGGGGGPRLRGGERLLFLFSRMLLVAKRR----GLEYTYKGHIFCCNLSVSESPRD--P 374

Query: 488 HTFQVSG----KERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAK----DND 539
             F+VS     K R L LQA + ++K  WI  LQ     F + H     A AK    +N 
Sbjct: 375 LGFKVSDLTIPKHRHL-LQAKNQEEKRLWIHCLQR---LFFENHPASIPAKAKQVLLENS 430

Query: 540 IHS--------EVSTAELGKRAPR 555
           +H         E  T  LG   PR
Sbjct: 431 LHCAPKSKPVLEPLTPPLGSPRPR 454


>gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]
          Length = 709

 Score = 91.7 bits (226), Expect = 2e-18
 Identities = 88/360 (24%), Positives = 163/360 (45%), Gaps = 45/360 (12%)

Query: 188 LELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPA 247
           +EL  LDQ      T E+K  +   E+L +E +Y + L +L + F   L  +  R +   
Sbjct: 270 VELGILDQ----LSTEERKRQEAMFEILTSEFSYQHSLSILVEEF---LQSKELRATVTQ 322

Query: 248 EMVNKIFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFD 307
              + +FSNI  +     +F   +LE+R +       I DIL++ A   K +  Y+    
Sbjct: 323 MEHHHLFSNILDVLGASQRFF-EDLEQRHKAQVLVEDISDILEEHAE--KHFHPYIAYCS 379

Query: 308 NAMELVKNMTERIPQ---FKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLR 364
           N +   + + + I     F+  + EI+++  CG L +   ++ P+QR+ R  +L+     
Sbjct: 380 NEVYQQRTLQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCL 439

Query: 365 KLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLG----EEEDIVNPS 420
           K    S  +  A ++L+ IS      N    +ME ++++  ++  L     +   +++ S
Sbjct: 440 KTQGHSERYKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKVKSLPLISAS 499

Query: 421 NELIKEGQIL---------KLAARNTSAQERYLFLFNNMLLYCVPKF--SLVGSKFTVRT 469
             L+K G++          K+A+R T     YLFLFN++L+    K   S +   +    
Sbjct: 500 RWLLKRGELFLVEETGLFRKIASRPTC----YLFLFNDVLVVTKKKSEESYMVQDYAQMN 555

Query: 470 RVGIDGMKIVE-------TQNEEYPHTFQVS------GKERTLELQASSAQDKEEWIKAL 516
            + ++ ++  E        ++   PH FQV+      G++  L L + SA D+  WI AL
Sbjct: 556 HIQVEKIEPSELPLPGGGNRSSSVPHPFQVTLLRNSEGRQEQLLLSSDSASDRARWIVAL 615


>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
          Length = 652

 Score = 90.5 bits (223), Expect = 5e-18
 Identities = 91/393 (23%), Positives = 173/393 (44%), Gaps = 42/393 (10%)

Query: 167 LEERGAETETKVQERENGESPLELEQLDQHHEMKETNEQKLHKIANELLLTERAYVNRL- 225
           L E  + T ++ Q+ E  +S          H   E  +Q    +  E++ TER Y+  L 
Sbjct: 210 LSENSSSTPSEEQDEEASQS---------RHRHCENKQQMRTNVIREIMDTERVYIKHLR 260

Query: 226 DLLD-QVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWET-TP 283
           D+ +  +  C+     + G F    +  IF NI  I  F  KF L +LEK+  + E    
Sbjct: 261 DICEGYIRQCR----KHTGMFTVAQLATIFGNIEDIYKFQRKF-LKDLEKQYNKEEPHLS 315

Query: 284 RIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQH 343
            IG    +      +Y EY      A   + N+ ++  +++   E  +  +    + +  
Sbjct: 316 EIGSCFLQNQEGFAIYSEYCNNHPGACLELANLMKQ-GKYRHFFEACRLLQQMIDIAIDG 374

Query: 344 HMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKL 403
            +L PVQ+I +Y + L + L+    +  D+++ K + E +   A   N   RK+E++ K+
Sbjct: 375 FLLTPVQKICKYPLQLAELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKI 434

Query: 404 L--EIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLV 461
              ++  +  E  DI++ S+ELI  G++ K+  +  S Q+R  FLF++ L+ C  K  L 
Sbjct: 435 ARWQVSIVGWEGLDILDRSSELIHSGELTKITKQGKS-QQRTFFLFDHQLVSC-KKDLLR 492

Query: 462 GSKFTVRTRVGIDGMKIVETQ-------NEEYPHTFQVSGK--ERTLELQASSAQDKEEW 512
                 + R+ +D M++V+         N    + F++  +  +      A   +DK  W
Sbjct: 493 RDMLYYKGRLDMDEMELVDLGDGRDKDCNLSVKNAFKLVSRTTDEVYLFCAKKQEDKARW 552

Query: 513 IKALQETIDAFHQRHETFRNAIAKDNDIHSEVS 545
           ++A  +            R  + +D ++  E+S
Sbjct: 553 LQACADE-----------RRRVQEDKEMGMEIS 574


>gi|45439359 triple functional domain (PTPRF interacting) [Homo
            sapiens]
          Length = 3097

 Score = 90.1 bits (222), Expect = 7e-18
 Identities = 86/353 (24%), Positives = 165/353 (46%), Gaps = 39/353 (11%)

Query: 193  LDQHHEMKETNEQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNK 252
            +D+  E K ++ ++ H +  EL+ TER YV  L  + + +   + E+      P +M  K
Sbjct: 1956 IDEMEERKSSSLKRRHYVLQELVETERDYVRDLGYVVEGYMALMKEDG----VPDDMKGK 2011

Query: 253  ---IFSNISSINAFHSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNA 309
               +F NI  I  +H  F L ELEK +++ E   ++G +  K    L MY  Y +    +
Sbjct: 2012 DKIVFGNIHQIYDWHRDFFLGELEKCLEDPE---KLGSLFVKHERRLHMYIAYCQNKPKS 2068

Query: 310  MELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPD 369
              +V        ++     E  KQ++   L L   +++PVQRI +Y++LLKD+L+     
Sbjct: 2069 EHIVS-------EYIDTFFEDLKQRLGHRLQLTDLLIKPVQRIMKYQLLLKDFLKYSKKA 2121

Query: 370  SLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQI 429
            SLD ++ ++++E++       N           ++ +  + G +  IV     L+++  +
Sbjct: 2122 SLDTSELERAVEVMCIVPRRCND----------MMNVGRLQGFDGKIVAQGKLLLQDTFL 2171

Query: 430  L--KLAARNTSAQERYLFLFNNMLLYCVP-----KFSLVGSKFTVRTRVGIDGM-KIVET 481
            +  + A      +ER +FLF  ++++  P      FS+ G  F    +V    + + VE 
Sbjct: 2172 VTDQDAGLLPRCRERRIFLFEQIVIFSEPLDKKKGFSMPGFLFKNSIKVSCLCLEENVEN 2231

Query: 482  QNEEYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAI 534
               ++  T +      T  L +SS   ++ WI  + + ++  +QR+  F NA+
Sbjct: 2232 DPCKFALTSRTGDVVETFILHSSSPSVRQTWIHEINQILE--NQRN--FLNAL 2280



 Score = 85.9 bits (211), Expect = 1e-16
 Identities = 87/346 (25%), Positives = 158/346 (45%), Gaps = 41/346 (11%)

Query: 189  ELEQLDQHHEMKETNEQKLHK---IANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSF 245
            E++  D  HE+ E   +   +   I  EL+ TE+AYV  L      +  ++         
Sbjct: 1272 EVKLRDAAHELNEEKRKSARRKEFIMAELIQTEKAYVRDLRECMDTYLWEMTSGVEE--I 1329

Query: 246  PAEMVNK---IFSNISSINAFHSKFLLPELEKRMQEWETTPR-IGDILQKLAPFLKMYGE 301
            P  +VNK   IF N+  I  FH+   L ELEK    +E  P  +G      A   +MY  
Sbjct: 1330 PPGIVNKELIIFGNMQEIYEFHNNIFLKELEK----YEQLPEDVGHCFVTWADKFQMYVT 1385

Query: 302  YVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKD 361
            Y K   ++ +L+      +    S  +EIQ++    + ++  ++++PVQRI +Y++LLK+
Sbjct: 1386 YCKNKPDSTQLI------LEHAGSYFDEIQQRHGLAN-SISSYLIKPVQRITKYQLLLKE 1438

Query: 362  YLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSN 421
             L           + K  LE++ +    +N A          + +  + G +E+I +   
Sbjct: 1439 LLTCCEEGK---GEIKDGLEVMLSVPKRANDA----------MHLSMLEGFDENIESQGE 1485

Query: 422  ELIKEG-QILKLAARNTSAQERYLFLFNNMLLYCVP-KFSLVGSKFTVRTRVGIDGMKIV 479
             +++E  Q+          +ER+LFLF   L++    K S   SK+  ++++    + + 
Sbjct: 1486 LILQESFQVWDPKTLIRKGRERHLFLFEMSLVFSKEVKDSSGRSKYLYKSKLFTSELGVT 1545

Query: 480  ETQNEEYPHTF-----QVSGKERTLELQASSAQDKEEWIKALQETI 520
            E   E  P  F     +    +  + L+ASS ++K++WIK ++E I
Sbjct: 1546 E-HVEGDPCKFALWVGRTPTSDNKIVLKASSIENKQDWIKHIREVI 1590


>gi|148839466 kalirin, RhoGEF kinase isoform 1 [Homo sapiens]
          Length = 2986

 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 90/355 (25%), Positives = 166/355 (46%), Gaps = 39/355 (10%)

Query: 210  IANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNK---IFSNISSINAFHSK 266
            + NEL+ TE+ YV  L ++ + F  ++ E+      P +M  K   +F NI  I  +H  
Sbjct: 1933 VLNELVQTEKDYVKDLGIVVEGFMKRIEEKG----VPEDMRGKDKIVFGNIHQIYDWHKD 1988

Query: 267  FLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSV 326
            F L ELEK +QE +   R+  +  K    L +Y  Y +    +  +V        ++ + 
Sbjct: 1989 FFLAELEKCIQEQD---RLAQLFIKHERKLHIYVWYCQNKPRSEYIVA-------EYDAY 2038

Query: 327  VEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTA 386
             EE+ KQ+I   LTL   +++P+QRI +Y++LLKD+LR      L+ +D +K++E++   
Sbjct: 2039 FEEV-KQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLV 2097

Query: 387  ASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFL 446
                N     M NL +L      L  +  ++      + E      A   +  +ER +FL
Sbjct: 2098 PKRCND----MMNLGRLQGFEGTLTAQGKLLQQDTFYVIELD----AGMQSRTKERRVFL 2149

Query: 447  FNNMLLY--CVPKFSLV-GSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERT--LEL 501
            F  ++++   + K SL  G  F    ++      ++E   +  P  F +  +E +  + L
Sbjct: 2150 FEQIVIFSELLRKGSLTPGYMFKRSIKM---NYLVLEENVDNDPCKFALMNRETSERVVL 2206

Query: 502  QASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDI-HSEVSTAELGKRAPR 555
            QA++A  ++ W++ + + ++        F NA+    +    E STA +  +  R
Sbjct: 2207 QAANADIQQAWVQDINQVLET----QRDFLNALQSPIEYQRKERSTAVMRSQPAR 2257



 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 92/351 (26%), Positives = 164/351 (46%), Gaps = 45/351 (12%)

Query: 186  SPLELEQLDQHHEMKETNEQKLHK---IANELLLTERAYVNRLDLLDQVFYCKLLEEANR 242
            S  E++  D +HE+ E   +   K   I  ELL TE+AYV  L    + +  ++      
Sbjct: 1258 SDREVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEE 1317

Query: 243  GSFPAEMVNK---IFSNISSINAFHSKFLLPELEKRMQEWETTPR-IGDILQKLAPFLKM 298
               P  ++NK   IF NI  I  FH+   L ELEK    +E  P  +G      A   +M
Sbjct: 1318 --IPPGILNKEHIIFGNIQEIYDFHNNIFLKELEK----YEQLPEDVGHCFVTWADKFQM 1371

Query: 299  YGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEML 358
            Y  Y K   ++ +L+      +    +  +EIQ++    + ++  ++++PVQRI +Y++L
Sbjct: 1372 YVTYCKNKPDSNQLI------LEHAGTFFDEIQQRHGLAN-SISSYLIKPVQRITKYQLL 1424

Query: 359  LKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSA--IRKMENLKKLLEIY-EMLGEEED 415
            LK+ L           + K  LE++ +    +N A  +  +E   + L++  E++ ++  
Sbjct: 1425 LKELLTCCEEGK---GELKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAF 1481

Query: 416  IVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVP-KFSLVGSKFTVRTRVGID 474
             V     LI++G            +ER+LFLF   L++    K S   +K+  + ++   
Sbjct: 1482 QVWDPKSLIRKG------------RERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTS 1529

Query: 475  GMKIVETQNEEYPHTFQV-SGK----ERTLELQASSAQDKEEWIKALQETI 520
             + + E   E  P  F + SG+    +    L+AS+ + K+EWIK ++E I
Sbjct: 1530 ELGVTE-HVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNIREVI 1579


>gi|68362740 kalirin, RhoGEF kinase isoform 3 [Homo sapiens]
          Length = 1289

 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 90/355 (25%), Positives = 166/355 (46%), Gaps = 39/355 (10%)

Query: 210 IANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNK---IFSNISSINAFHSK 266
           + NEL+ TE+ YV  L ++ + F  ++ E+      P +M  K   +F NI  I  +H  
Sbjct: 236 VLNELVQTEKDYVKDLGIVVEGFMKRIEEKG----VPEDMRGKDKIVFGNIHQIYDWHKD 291

Query: 267 FLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERIPQFKSV 326
           F L ELEK +QE +   R+  +  K    L +Y  Y +    +  +V        ++ + 
Sbjct: 292 FFLAELEKCIQEQD---RLAQLFIKHERKLHIYVWYCQNKPRSEYIVA-------EYDAY 341

Query: 327 VEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTA 386
            EE+ KQ+I   LTL   +++P+QRI +Y++LLKD+LR      L+ +D +K++E++   
Sbjct: 342 FEEV-KQEINQRLTLSDFLIKPIQRITKYQLLLKDFLRYSEKAGLECSDIEKAVELMCLV 400

Query: 387 ASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFL 446
               N     M NL +L      L  +  ++      + E      A   +  +ER +FL
Sbjct: 401 PKRCND----MMNLGRLQGFEGTLTAQGKLLQQDTFYVIELD----AGMQSRTKERRVFL 452

Query: 447 FNNMLLY--CVPKFSLV-GSKFTVRTRVGIDGMKIVETQNEEYPHTFQVSGKERT--LEL 501
           F  ++++   + K SL  G  F    ++      ++E   +  P  F +  +E +  + L
Sbjct: 453 FEQIVIFSELLRKGSLTPGYMFKRSIKM---NYLVLEENVDNDPCKFALMNRETSERVVL 509

Query: 502 QASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKDNDI-HSEVSTAELGKRAPR 555
           QA++A  ++ W++ + + ++        F NA+    +    E STA +  +  R
Sbjct: 510 QAANADIQQAWVQDINQVLET----QRDFLNALQSPIEYQRKERSTAVMRSQPAR 560


>gi|13375827 phafin 2 [Homo sapiens]
          Length = 249

 Score = 89.0 bits (219), Expect = 2e-17
 Identities = 52/202 (25%), Positives = 96/202 (47%), Gaps = 22/202 (10%)

Query: 419 PSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVRTRVGIDGMKI 478
           P   LI EG + KL  +   A  R  FLFN++L+Y      +   K+  +  + ++ + I
Sbjct: 32  PGRVLIGEGVLTKLCRKKPKA--RQFFLFNDILVY--GNIVIQKKKYNKQHIIPLENVTI 87

Query: 479 VETQNE-EYPHTFQVSGKERTLELQASSAQDKEEWIKALQETIDAFHQRHETFRNAIAKD 537
              ++E +  + + +    ++  + A++A +K EW+  + + +                 
Sbjct: 88  DSIKDEGDLRNGWLIKTPTKSFAVYAATATEKSEWMNHINKCV----------------- 130

Query: 538 NDIHSEVSTAELGKRAPRWIRDNEVTMCMKCKEPFNALTRRRHHCRACGYVVCWKCSDYK 597
            D+ S+       + A  W+ D+E T+CM+C++       RRHHCR CG+VVC  CS+ +
Sbjct: 131 TDLLSKSGKTPSNEHAAVWVPDSEATVCMRCQKAKFTPVNRRHHCRKCGFVVCGPCSEKR 190

Query: 598 AQLEYDGGKLSKVCKDCYQIIS 619
             L     K  ++C  CY ++S
Sbjct: 191 FLLPSQSSKPVRICDFCYDLLS 212


>gi|194473700 Src homology 3 domain-containing guanine nucleotide
           exchange factor [Homo sapiens]
          Length = 871

 Score = 87.4 bits (215), Expect = 4e-17
 Identities = 72/261 (27%), Positives = 128/261 (49%), Gaps = 18/261 (6%)

Query: 204 EQKLHKIANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAF 263
           E+K  +   E++ +E +Y+  L++L ++F  K  +E +      E  + +FSNI+ +   
Sbjct: 437 ERKRQEAIFEVISSEHSYLLSLEILIRMF--KNSKELSDTMTKTER-HHLFSNITDVCEA 493

Query: 264 HSKFLLPELEKRMQEWETTPRIGDILQKLAPFLKMYGEYVKGFDNAMELVKNMTERI--- 320
             KF + ELE R Q       I DI++K       +  YVK   N +   + + + +   
Sbjct: 494 SKKFFI-ELEARHQNNIFIDDISDIVEKHTA--STFDPYVKYCTNEVYQQRTLQKLLATN 550

Query: 321 PQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSL 380
           P FK V+  I+  + C +L +   ++ P+QR+ R  +L+    +K P DS  +   K++L
Sbjct: 551 PSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKRAL 610

Query: 381 EIISTAASHSNSAIRKMENLKKLLEIYEMLG---EEEDIVNPSNELIKEGQILK------ 431
           + +S      N   RKME  + +  I   L    +   +V+ S  L+K G++        
Sbjct: 611 KEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSSRWLVKRGELTAYVEDTV 670

Query: 432 LAARNTSAQERYLFLFNNMLL 452
           L +R TS Q+ Y FLFN++L+
Sbjct: 671 LFSRRTSKQQVYFFLFNDVLI 691


>gi|7662108 Cdc42 guanine exchange factor 9 [Homo sapiens]
          Length = 516

 Score = 86.3 bits (212), Expect = 1e-16
 Identities = 95/387 (24%), Positives = 167/387 (43%), Gaps = 40/387 (10%)

Query: 180 ERENGESPLELEQLDQHHEMK------ETNEQKLHKIANELLLTERAYVNRL-DLLDQVF 232
           E E G S ++   LD + +        +  +Q    + NE++ TER Y+  L D+ +   
Sbjct: 71  EVEEGPSDVQNGHLDPNSDCLCLGRPLQNRDQMRANVINEIMSTERHYIKHLKDICEG-- 128

Query: 233 YCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLLPELEKRMQEWET-TPRIGDILQK 291
           Y K   +  R  F  E +  IF NI  I  F   F+  +LEK+    +     IG    +
Sbjct: 129 YLKQCRK-RRDMFSDEQLKVIFGNIEDIYRFQMGFVR-DLEKQYNNDDPHLSEIGPCFLE 186

Query: 292 LAPFLKMYGEYVKG-FDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQ 350
                 +Y EY     D  MEL K M +   Q       + +Q I   + +   +L PVQ
Sbjct: 187 HQDGFWIYSEYCNNHLDACMELSKLMKDSRYQHFFEACRLLQQMI--DIAIDGFLLTPVQ 244

Query: 351 RIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSAIRKMENLKKLLEIYEML 410
           +I +Y + L + L+    D  D+     +L ++       N   R++EN+ K+ +    +
Sbjct: 245 KICKYPLQLAELLKYTAQDHSDYRYVAAALAVMRNVTQQINERKRRLENIDKIAQWQASV 304

Query: 411 --GEEEDIVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVPKFSLVGSKFTVR 468
              E EDI++ S+ELI  G++  +       Q+R  FLF++ ++ C  K  +       +
Sbjct: 305 LDWEGEDILDRSSELIYTGEMAWIYQPYGRNQQRVFFLFDHQMVLC-KKDLIRRDILYYK 363

Query: 469 TRVGIDGMKIVETQ-------NEEYPHTFQVSGKERTLELQ---ASSAQDKEEWIKALQE 518
            R+ +D  ++V+ +       N    + F++  KE T E+    A   ++K  W++A +E
Sbjct: 364 GRIDMDKYEVVDIEDGRDDDFNVSMKNAFKLHNKE-TEEIHLFFAKKLEEKIRWLRAFRE 422

Query: 519 TIDAFHQRHETFRNAIAKDNDIHSEVS 545
                       R  + +D  I  E+S
Sbjct: 423 E-----------RKMVQEDEKIGFEIS 438


>gi|4504335 kalirin, RhoGEF kinase isoform 2 [Homo sapiens]
          Length = 1663

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 92/351 (26%), Positives = 164/351 (46%), Gaps = 45/351 (12%)

Query: 186  SPLELEQLDQHHEMKETNEQKLHK---IANELLLTERAYVNRLDLLDQVFYCKLLEEANR 242
            S  E++  D +HE+ E   +   K   I  ELL TE+AYV  L    + +  ++      
Sbjct: 1258 SDREVKLRDANHEVNEEKRKSARKKEFIMAELLQTEKAYVRDLHECLETYLWEMTSGVEE 1317

Query: 243  GSFPAEMVNK---IFSNISSINAFHSKFLLPELEKRMQEWETTPR-IGDILQKLAPFLKM 298
               P  ++NK   IF NI  I  FH+   L ELEK    +E  P  +G      A   +M
Sbjct: 1318 --IPPGILNKEHIIFGNIQEIYDFHNNIFLKELEK----YEQLPEDVGHCFVTWADKFQM 1371

Query: 299  YGEYVKGFDNAMELVKNMTERIPQFKSVVEEIQKQKICGSLTLQHHMLEPVQRIPRYEML 358
            Y  Y K   ++ +L+      +    +  +EIQ++    + ++  ++++PVQRI +Y++L
Sbjct: 1372 YVTYCKNKPDSNQLI------LEHAGTFFDEIQQRHGLAN-SISSYLIKPVQRITKYQLL 1424

Query: 359  LKDYLRKLPPDSLDWNDAKKSLEIISTAASHSNSA--IRKMENLKKLLEIY-EMLGEEED 415
            LK+ L           + K  LE++ +    +N A  +  +E   + L++  E++ ++  
Sbjct: 1425 LKELLTCCEEGK---GELKDGLEVMLSVPKKANDAMHVSMLEGFDENLDVQGELILQDAF 1481

Query: 416  IVNPSNELIKEGQILKLAARNTSAQERYLFLFNNMLLYCVP-KFSLVGSKFTVRTRVGID 474
             V     LI++G            +ER+LFLF   L++    K S   +K+  + ++   
Sbjct: 1482 QVWDPKSLIRKG------------RERHLFLFEISLVFSKEIKDSSGHTKYVYKNKLLTS 1529

Query: 475  GMKIVETQNEEYPHTFQV-SGK----ERTLELQASSAQDKEEWIKALQETI 520
             + + E   E  P  F + SG+    +    L+AS+ + K+EWIK ++E I
Sbjct: 1530 ELGVTE-HVEGDPCKFALWSGRTPSSDNKTVLKASNIETKQEWIKNIREVI 1579


>gi|58761492 Rho guanine nucleotide exchange factor (GEF) 10-like
           isoform 1 [Homo sapiens]
          Length = 1279

 Score = 84.0 bits (206), Expect = 5e-16
 Identities = 75/304 (24%), Positives = 141/304 (46%), Gaps = 44/304 (14%)

Query: 210 IANELLLTERAYVNRLDLLDQVFYCKLLEEANRGSFPAEMVNKIFSNISSINAFHSKFLL 269
           I   ++ +E +YV  L  + Q +   L+E   + +  A     +F  +  I   HS F +
Sbjct: 320 ILGSIVQSEGSYVESLKRILQDYRNPLMEMEPK-ALSARKCQVVFFRVKEILHCHSMFQI 378

Query: 270 PELEKRMQEWETTPRIGDILQKLAPFLK-----MYGEYVKGFDNAMELVKNMTERIPQFK 324
             L  R+ EW++T +IGD+   +A F K     +Y +YV  F +AM ++K      P F 
Sbjct: 379 A-LSSRVAEWDSTEKIGDLF--VASFSKSMVLDVYSDYVNNFTSAMSIIKKACLTKPAF- 434

Query: 325 SVVEEIQKQKICGS--LTLQHHMLEPVQRIPRYEMLLKDYLRKLPPDSLDWNDAKKSLEI 382
             +E ++++++C    +TL   M++P+QR P++ +LL+D L+  P    D    + +L  
Sbjct: 435 --LEFLKRRQVCSPDRVTLYGLMVKPIQRFPQFILLLQDMLKNTPRGHPDRLSLQLALTE 492

Query: 383 ISTAASHSNSAIRKMENLKKLLEIYEMLGEEEDIVNPSNELIKEGQILKLAARNTS---- 438
           + T A   N   R  + + ++ ++ + + +   +    N+L+  GQ   L     +    
Sbjct: 493 LETLAEKLNEQKRLADQVAEIQQLTKSVSDRSSL----NKLLTSGQRQLLLCETLTETVY 548

Query: 439 --------AQERYLFLFNNMLLYCVPKF------------SLV--GSKFTVRTRVGIDGM 476
                   ++ER +FL N+ML+     F            SLV  G K+ V+    +  +
Sbjct: 549 GDRGQLIKSKERRVFLLNDMLVCANINFKPANHRGQLEISSLVPLGPKYVVKWNTALPQV 608

Query: 477 KIVE 480
           ++VE
Sbjct: 609 QVVE 612


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.130    0.376 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,239,958
Number of Sequences: 37866
Number of extensions: 1399473
Number of successful extensions: 4803
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 136
Number of HSP's successfully gapped in prelim test: 146
Number of HSP's that attempted gapping in prelim test: 4272
Number of HSP's gapped (non-prelim): 450
length of query: 766
length of database: 18,247,518
effective HSP length: 110
effective length of query: 656
effective length of database: 14,082,258
effective search space: 9237961248
effective search space used: 9237961248
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.