Guide to the Human Genome
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Search of human proteins with 19743898

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|19743898 receptor tyrosine kinase-like orphan receptor 2
precursor [Homo sapiens]
         (943 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|19743898 receptor tyrosine kinase-like orphan receptor 2 prec...  1950   0.0  
gi|134152725 receptor tyrosine kinase-like orphan receptor 1 iso...  1070   0.0  
gi|134152686 receptor tyrosine kinase-like orphan receptor 1 iso...   520   e-147
gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]    301   2e-81
gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isofo...   246   7e-65
gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isofo...   246   7e-65
gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isofo...   246   9e-65
gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isofo...   239   1e-62
gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isofo...   238   2e-62
gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isofor...   238   2e-62
gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isofo...   238   2e-62
gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]             206   1e-52
gi|119395738 insulin receptor isoform Short precursor [Homo sapi...   205   2e-52
gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]   205   2e-52
gi|62420886 discoidin domain receptor family, member 2 precursor...   204   2e-52
gi|62420884 discoidin domain receptor family, member 2 precursor...   204   2e-52
gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo sap...   204   3e-52
gi|4758280 ephrin receptor EphA4 [Homo sapiens]                       203   5e-52
gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo sapi...   202   9e-52
gi|47524177 fibroblast growth factor receptor 4 isoform 2 precur...   201   3e-51
gi|47524175 fibroblast growth factor receptor 4 isoform 1 precur...   201   3e-51
gi|47524173 fibroblast growth factor receptor 4 isoform 1 precur...   201   3e-51
gi|32528301 EPH receptor B4 precursor [Homo sapiens]                  199   1e-50
gi|4557665 insulin-like growth factor 1 receptor precursor [Homo...   198   2e-50
gi|38327632 discoidin domain receptor family, member 1 isoform b...   198   2e-50
gi|83977450 discoidin domain receptor family, member 1 isoform a...   198   2e-50
gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]   197   3e-50
gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]   197   3e-50
gi|32967311 ephrin receptor EphA2 [Homo sapiens]                      197   4e-50
gi|4758282 ephrin receptor EphA7 [Homo sapiens]                       197   5e-50

>gi|19743898 receptor tyrosine kinase-like orphan receptor 2
           precursor [Homo sapiens]
          Length = 943

 Score = 1950 bits (5051), Expect = 0.0
 Identities = 943/943 (100%), Positives = 943/943 (100%)

Query: 1   MARGSALPRRPLLCIPAVWAAAALLLSVSRTSGEVEVLDPNDPLGPLDGQDGPIPTLKGY 60
           MARGSALPRRPLLCIPAVWAAAALLLSVSRTSGEVEVLDPNDPLGPLDGQDGPIPTLKGY
Sbjct: 1   MARGSALPRRPLLCIPAVWAAAALLLSVSRTSGEVEVLDPNDPLGPLDGQDGPIPTLKGY 60

Query: 61  FLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRL 120
           FLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRL
Sbjct: 61  FLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRL 120

Query: 121 RIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGI 180
           RIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGI
Sbjct: 121 RIQDLDTTDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGI 180

Query: 181 ACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCD 240
           ACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCD
Sbjct: 181 ACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCD 240

Query: 241 ARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANC 300
           ARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANC
Sbjct: 241 ARSRTPKPRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANC 300

Query: 301 MRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGG 360
           MRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGG
Sbjct: 301 MRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGG 360

Query: 361 GHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVPSIAIPLVIAC 420
           GHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVPSIAIPLVIAC
Sbjct: 361 GHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVPSIAIPLVIAC 420

Query: 421 LFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISLSAVRFMEELG 480
           LFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISLSAVRFMEELG
Sbjct: 421 LFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHKQAKLKEISLSAVRFMEELG 480

Query: 481 EDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLL 540
           EDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLL
Sbjct: 481 EDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLL 540

Query: 541 GVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIA 600
           GVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIA
Sbjct: 541 GVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIA 600

Query: 601 AGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMA 660
           AGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMA
Sbjct: 601 AGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMA 660

Query: 661 PEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAW 720
           PEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAW
Sbjct: 661 PEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAW 720

Query: 721 VYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSN 780
           VYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSN
Sbjct: 721 VYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSN 780

Query: 781 VSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPAYGAYLPNFYPV 840
           VSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPAYGAYLPNFYPV
Sbjct: 781 VSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPAYGAYLPNFYPV 840

Query: 841 QIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQNA 900
           QIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQNA
Sbjct: 841 QIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTSMADRAALLSEGADDTQNA 900

Query: 901 PEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA 943
           PEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA
Sbjct: 901 PEDGAQSTVQEAEEEEEGSVPETELLGDCDTLQVDEAQVQLEA 943


>gi|134152725 receptor tyrosine kinase-like orphan receptor 1
           isoform 1 [Homo sapiens]
          Length = 937

 Score = 1070 bits (2766), Expect = 0.0
 Identities = 531/884 (60%), Positives = 656/884 (74%), Gaps = 20/884 (2%)

Query: 8   PRRPLLCIPAVWAAAALLLSVSRTSGEVEVLDPNDPLGPLDGQDGPIPTLKGYFLNFLEP 67
           PRR     P +   AALLL+    + +   L  +  L P    +      K  +L   EP
Sbjct: 4   PRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTLDEP 63

Query: 68  VNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDT 127
           +NNIT   GQTA LHCKV+GNPPP +RW KNDAPVVQEPRR+  R T YGSRLRI++LDT
Sbjct: 64  MNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDT 123

Query: 128 TDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGIACARFIG 187
           TDTGY+QCVATNG + +++TGVLFV+ GP  + +  + D+Y EDGFCQPYRGIACARFIG
Sbjct: 124 TDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGIACARFIG 183

Query: 188 NRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCDARSRTPK 247
           NRT+Y++SL MQGEIEN+ITAAFTMIGTS+HLSD+CSQFAIPS CH+ FP CD  S  PK
Sbjct: 184 NRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSSVPK 243

Query: 248 PRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIGIP- 306
           PR+LCRDECE+LE+ LC+ EY  ARSNP+ILMRL+LP CE LP PESP+AANC+RIGIP 
Sbjct: 244 PRDLCRDECEILENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRIGIPM 303

Query: 307 AERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAYCR 366
           A+ + + H+CYN +G+DYRGT S TKSG QCQPW  Q+PH+H  ++  FPEL GGH+YCR
Sbjct: 304 ADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHSYCR 363

Query: 367 NPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDS---SKMGILYILVPSIAIPLVIACLFF 423
           NPG Q E PWCFT ++N + +LCD+P+C  +DS   +KM ILYILVPS+AIPL IA LFF
Sbjct: 364 NPGNQKEAPWCFTLDENFKSDLCDIPACDSKDSKEKNKMEILYILVPSVAIPLAIALLFF 423

Query: 424 LVCMCRNKQKASASTPQRRQLMASPSQDMEMPLINQHK-QAKLKEISLSAVRFMEELGED 482
            +C+CRN QK S+S P +RQ      Q++EM ++N +K ++K KE+ LSAVRFMEELGE 
Sbjct: 424 FICVCRNNQK-SSSAPVQRQPKHVRGQNVEMSMLNAYKPKSKAKELPLSAVRFMEELGEC 482

Query: 483 RFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGV 542
            FGK+YKGHL+ P   +  Q VAIKTLKD        EF+ EA L A L HPN+VCLLG 
Sbjct: 483 AFGKIYKGHLYLPGM-DHAQLVAIKTLKDYNNPQQWTEFQQEASLMAELHHPNIVCLLGA 541

Query: 543 VTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVG-STDDDRTVKSALEPPDFVHLVAQIAA 601
           VT++QP+ M+F Y + GDLHEFL+MRSPHSDVG S+D+D TVKS+L+  DF+H+  QIAA
Sbjct: 542 VTQEQPVCMLFEYINQGDLHEFLIMRSPHSDVGCSSDEDGTVKSSLDHGDFLHIAIQIAA 601

Query: 602 GMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIRWMAP 661
           GMEYLSSH  VHKDLA RN+L+ ++L+VKISDLGL RE+Y+ADYY++   SLLPIRWM P
Sbjct: 602 GMEYLSSHFFVHKDLAARNILIGEQLHVKISDLGLSREIYSADYYRVQSKSLLPIRWMPP 661

Query: 662 EAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWV 721
           EAIMYGKFS DSDIWS+GVVLWE+FS+GLQPY G+SNQ+V+EM+R RQ+LPC +DCP  +
Sbjct: 662 EAIMYGKFSSDSDIWSFGVVLWEIFSFGLQPYYGFSNQEVIEMVRKRQLLPCSEDCPPRM 721

Query: 722 YALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASNTTQTSSLSTSPVSNV 781
           Y+LM ECWNE PSRRPRFKDIH RLR+W  LS++ SS   SG + TTQT+SLS SPVSN+
Sbjct: 722 YSLMTECWNEIPSRRPRFKDIHVRLRSWEGLSSHTSSTTPSGGNATTQTTSLSASPVSNL 781

Query: 782 SNAR---YVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQPVPAYGAYLPNFY 838
           SN R   Y+ P Q   P  Q     + G I P +P  Q ++P+NGY   P Y A+    Y
Sbjct: 782 SNPRYPNYMFPSQGITPQGQ-----IAGFIGPPIPQNQRFIPINGYPIPPGYAAFPAAHY 836

Query: 839 PVQIPMQMAPQQVPPQMVPKPSSHHSGSGSTSTGYVTTAPSNTS 882
               P ++  Q  PP   PK  S  S SGSTSTG+VT+ PS+ S
Sbjct: 837 QPTGPPRVI-QHCPP---PKSRSPSSASGSTSTGHVTSLPSSGS 876


>gi|134152686 receptor tyrosine kinase-like orphan receptor 1
           isoform 2 [Homo sapiens]
          Length = 393

 Score =  520 bits (1338), Expect = e-147
 Identities = 240/388 (61%), Positives = 295/388 (76%), Gaps = 1/388 (0%)

Query: 8   PRRPLLCIPAVWAAAALLLSVSRTSGEVEVLDPNDPLGPLDGQDGPIPTLKGYFLNFLEP 67
           PRR     P +   AALLL+    + +   L  +  L P    +      K  +L   EP
Sbjct: 4   PRRRGTRPPLLALLAALLLAARGAAAQETELSVSAELVPTSSWNISSELNKDSYLTLDEP 63

Query: 68  VNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDT 127
           +NNIT   GQTA LHCKV+GNPPP +RW KNDAPVVQEPRR+  R T YGSRLRI++LDT
Sbjct: 64  MNNITTSLGQTAELHCKVSGNPPPTIRWFKNDAPVVQEPRRLSFRSTIYGSRLRIRNLDT 123

Query: 128 TDTGYYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYRGIACARFIG 187
           TDTGY+QCVATNG + +++TGVLFV+ GP  + +  + D+Y EDGFCQPYRGIACARFIG
Sbjct: 124 TDTGYFQCVATNGKEVVSSTGVLFVKFGPPPTASPGYSDEYEEDGFCQPYRGIACARFIG 183

Query: 188 NRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPLCDARSRTPK 247
           NRT+Y++SL MQGEIEN+ITAAFTMIGTS+HLSD+CSQFAIPS CH+ FP CD  S  PK
Sbjct: 184 NRTVYMESLHMQGEIENQITAAFTMIGTSSHLSDKCSQFAIPSLCHYAFPYCDETSSVPK 243

Query: 248 PRELCRDECEVLESDLCRQEYTIARSNPLILMRLQLPKCEALPMPESPDAANCMRIGIP- 306
           PR+LCRDECE+LE+ LC+ EY  ARSNP+ILMRL+LP CE LP PESP+AANC+RIGIP 
Sbjct: 244 PRDLCRDECEILENVLCQTEYIFARSNPMILMRLKLPNCEDLPQPESPEAANCIRIGIPM 303

Query: 307 AERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSSTDFPELGGGHAYCR 366
           A+ + + H+CYN +G+DYRGT S TKSG QCQPW  Q+PH+H  ++  FPEL GGH+YCR
Sbjct: 304 ADPINKNHKCYNSTGVDYRGTVSVTKSGRQCQPWNSQYPHTHTFTALRFPELNGGHSYCR 363

Query: 367 NPGGQMEGPWCFTQNKNVRMELCDVPSC 394
           NPG Q E PWCFT ++N + +LCD+P+C
Sbjct: 364 NPGNQKEAPWCFTLDENFKSDLCDIPAC 391


>gi|5031927 skeletal muscle receptor tyrosine kinase [Homo sapiens]
          Length = 869

 Score =  301 bits (771), Expect = 2e-81
 Identities = 206/725 (28%), Positives = 321/725 (44%), Gaps = 99/725 (13%)

Query: 61  FLNFLEPVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRL 120
           F   L    +  +  G    LHC   G P P + W++N   V     +  ++     SRL
Sbjct: 211 FARILRAPESHNVTFGSFVTLHCTATGIPVPTITWIENGNAVSSGSIQESVKDRVIDSRL 270

Query: 121 RIQDLDTTDTGYYQCVATN--GMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPYR 178
           +   L  T  G Y C+ATN  G K  TA     + +     P  +        G+C  YR
Sbjct: 271 Q---LFITKPGLYTCIATNKHGEKFSTAKAAATISIAEWSKPQKD------NKGYCAQYR 321

Query: 179 GIACARFIGNRTIYVDSLQMQGEIENRITAAFTMIGTSTHLSDQCSQFAIPSFCHFVFPL 238
           G  C   +    +   +       E +     T       +S  C   A    C+ +F  
Sbjct: 322 GEVCNAVLAKDALVFLNTSYADPEEAQELLVHTAWNELKVVSPVCRPAAEALLCNHIFQE 381

Query: 239 CDARSRTPKPRELCRDECEVLESDLCRQEYTIARSNP------LILMRLQLPKCEALPMP 292
           C      P P  +CR+ C  ++   C +E+ +             +  L +P+C  LP  
Sbjct: 382 CSP-GVVPTPIPICREYCLAVKELFCAKEWLVMEEKTHRGLYRSEMHLLSVPECSKLPSM 440

Query: 293 ESPDAANCMRIGIPAERLGRYHQCYNGSGMDYRGTASTTKSGHQCQPWALQHPHSHHLSS 352
              D   C R+          H  YN   +      +++K                   S
Sbjct: 441 HW-DPTACARLP---------HLDYNKENLKTFPPMTSSKP------------------S 472

Query: 353 TDFPELGGGHAYCRNPGGQMEGPWCFTQNKNVRMELCDVPSCSPRDSSKMGILYILVPSI 412
            D P L    +                             S S   +  M ++  ++ S 
Sbjct: 473 VDIPNLPSSSS----------------------------SSFSVSPTYSMTVIISIMSSF 504

Query: 413 AIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDM-----------EMPLINQHK 461
           AI +++       C  R + K          L   PS+ +            MPL+   K
Sbjct: 505 AIFVLLTITTLYCCRRRKQWKNKKRESAAVTLTTLPSELLLDRLHPNPMYQRMPLLLNPK 564

Query: 462 QAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEF 521
              L E   + + ++ ++GE  FG+V++    G  P E    VA+K LK++A   ++ +F
Sbjct: 565 LLSL-EYPRNNIEYVRDIGEGAFGRVFQARAPGLLPYEPFTMVAVKMLKEEASADMQADF 623

Query: 522 RHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDR 581
           + EA L A   +PN+V LLGV    +P+ ++F Y ++GDL+EFL   SPH+    +  D 
Sbjct: 624 QREAALMAEFDNPNIVKLLGVCAVGKPMCLLFEYMAYGDLNEFLRSMSPHTVCSLSHSDL 683

Query: 582 TVKSALEPP--------DFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISD 633
           ++++ +  P        + + +  Q+AAGM YLS    VH+DLATRN LV + + VKI+D
Sbjct: 684 SMRAQVSSPGPPPLSCAEQLCIARQVAAGMAYLSERKFVHRDLATRNCLVGENMVVKIAD 743

Query: 634 LGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPY 693
            GL R +Y+ADYYK   N  +PIRWM PE+I Y +++ +SD+W+YGVVLWE+FSYGLQPY
Sbjct: 744 FGLSRNIYSADYYKANENDAIPIRWMPPESIFYNRYTTESDVWAYGVVLWEIFSYGLQPY 803

Query: 694 CGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRL-----RA 748
            G ++++V+  +R+  +L CP++CP  +Y LM  CW++ P+ RP F  IH  L     RA
Sbjct: 804 YGMAHEEVIYYVRDGNILSCPENCPVELYNLMRLCWSKLPADRPSFTSIHRILERMCERA 863

Query: 749 WGNLS 753
            G +S
Sbjct: 864 EGTVS 868



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 31/77 (40%), Positives = 46/77 (59%), Gaps = 4/77 (5%)

Query: 67  PVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLD 126
           P  N+ I++G  A+L C   GNP P+V W+K D+P+ +  R  ++   E GS LRI ++ 
Sbjct: 126 PPINVKIIEGLKAVLPCTTMGNPKPSVSWIKGDSPLRENSRIAVL---ESGS-LRIHNVQ 181

Query: 127 TTDTGYYQCVATNGMKT 143
             D G Y+CVA N + T
Sbjct: 182 KEDAGQYRCVAKNSLGT 198



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 26/91 (28%), Positives = 41/91 (45%), Gaps = 3/91 (3%)

Query: 67  PVNNITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLD 126
           P+  +  +  + A   C V   P P + W +N   +     R  IR  E G  L I  ++
Sbjct: 33  PLETVDALVEEVATFMCAVESYPQPEISWTRNKILIKLFDTRYSIR--ENGQLLTILSVE 90

Query: 127 TTDTGYYQCVATNGM-KTITATGVLFVRLGP 156
            +D G Y C A NG+   + + G L V++ P
Sbjct: 91  DSDDGIYCCTANNGVGGAVESCGALQVKMKP 121


>gi|65506745 neurotrophic tyrosine kinase, receptor, type 2 isoform
           c precursor [Homo sapiens]
          Length = 822

 Score =  246 bits (628), Expect = 7e-65
 Identities = 125/270 (46%), Positives = 169/270 (62%), Gaps = 4/270 (1%)

Query: 478 ELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVV 537
           ELGE  FGKV+    +   P +    VA+KTLKD ++   R++F  EA L   LQH ++V
Sbjct: 543 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNA-RKDFHREAELLTNLQHEHIV 601

Query: 538 CLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVA 597
              GV  +  PL M+F Y  HGDL++FL    P + + +  +  T    L     +H+  
Sbjct: 602 KFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPT---ELTQSQMLHIAQ 658

Query: 598 QIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIR 657
           QIAAGM YL+S H VH+DLATRN LV + L VKI D G+ R+VY+ DYY++ G+++LPIR
Sbjct: 659 QIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIR 718

Query: 658 WMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDC 717
           WM PE+IMY KF+ +SD+WS GVVLWE+F+YG QP+   SN +V+E I   +VL  P  C
Sbjct: 719 WMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTC 778

Query: 718 PAWVYALMIECWNEFPSRRPRFKDIHSRLR 747
           P  VY LM+ CW   P  R   K IH+ L+
Sbjct: 779 PQEVYELMLGCWQREPHMRKNIKGIHTLLQ 808



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 30/109 (27%), Positives = 51/109 (46%), Gaps = 9/109 (8%)

Query: 70  NITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTD 129
           N+T+ +G++  L C VAG+P PN+ W      V     + +   +     LRI ++ + D
Sbjct: 205 NLTVEEGKSITLSCSVAGDPVPNMYW-----DVGNLVSKHMNETSHTQGSLRITNISSDD 259

Query: 130 TG-YYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPY 177
           +G    CVA N +     +  L V   PT +   +   D+H   +C P+
Sbjct: 260 SGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH---WCIPF 305



 Score = 30.4 bits (67), Expect = 8.1
 Identities = 29/112 (25%), Positives = 46/112 (41%), Gaps = 12/112 (10%)

Query: 71  ITIVQGQTAILHC----KVAGNPPPNVRWLKNDAPVVQEPRRI-----IIRKTEYGSRLR 121
           IT ++  T+  H      V GNP P ++W  N A ++ E + I     +   TEY   L+
Sbjct: 289 ITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGA-ILNESKYICTKIHVTNHTEYHGCLQ 347

Query: 122 IQDLDTTDTGYYQCVATN--GMKTITATGVLFVRLGPTHSPNHNFQDDYHED 171
           + +    + G Y  +A N  G      +       G     N N+ D  +ED
Sbjct: 348 LDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYED 399


>gi|21361306 neurotrophic tyrosine kinase, receptor, type 2 isoform
           a precursor [Homo sapiens]
          Length = 838

 Score =  246 bits (628), Expect = 7e-65
 Identities = 125/270 (46%), Positives = 169/270 (62%), Gaps = 4/270 (1%)

Query: 478 ELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVV 537
           ELGE  FGKV+    +   P +    VA+KTLKD ++   R++F  EA L   LQH ++V
Sbjct: 559 ELGEGAFGKVFLAECYNLCPEQDKILVAVKTLKDASDNA-RKDFHREAELLTNLQHEHIV 617

Query: 538 CLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVA 597
              GV  +  PL M+F Y  HGDL++FL    P + + +  +  T    L     +H+  
Sbjct: 618 KFYGVCVEGDPLIMVFEYMKHGDLNKFLRAHGPDAVLMAEGNPPT---ELTQSQMLHIAQ 674

Query: 598 QIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIR 657
           QIAAGM YL+S H VH+DLATRN LV + L VKI D G+ R+VY+ DYY++ G+++LPIR
Sbjct: 675 QIAAGMVYLASQHFVHRDLATRNCLVGENLLVKIGDFGMSRDVYSTDYYRVGGHTMLPIR 734

Query: 658 WMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDC 717
           WM PE+IMY KF+ +SD+WS GVVLWE+F+YG QP+   SN +V+E I   +VL  P  C
Sbjct: 735 WMPPESIMYRKFTTESDVWSLGVVLWEIFTYGKQPWYQLSNNEVIECITQGRVLQRPRTC 794

Query: 718 PAWVYALMIECWNEFPSRRPRFKDIHSRLR 747
           P  VY LM+ CW   P  R   K IH+ L+
Sbjct: 795 PQEVYELMLGCWQREPHMRKNIKGIHTLLQ 824



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 30/109 (27%), Positives = 51/109 (46%), Gaps = 9/109 (8%)

Query: 70  NITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTD 129
           N+T+ +G++  L C VAG+P PN+ W      V     + +   +     LRI ++ + D
Sbjct: 205 NLTVEEGKSITLSCSVAGDPVPNMYW-----DVGNLVSKHMNETSHTQGSLRITNISSDD 259

Query: 130 TG-YYQCVATNGMKTITATGVLFVRLGPTHSPNHNFQDDYHEDGFCQPY 177
           +G    CVA N +     +  L V   PT +   +   D+H   +C P+
Sbjct: 260 SGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHH---WCIPF 305



 Score = 30.4 bits (67), Expect = 8.1
 Identities = 29/112 (25%), Positives = 46/112 (41%), Gaps = 12/112 (10%)

Query: 71  ITIVQGQTAILHC----KVAGNPPPNVRWLKNDAPVVQEPRRI-----IIRKTEYGSRLR 121
           IT ++  T+  H      V GNP P ++W  N A ++ E + I     +   TEY   L+
Sbjct: 289 ITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGA-ILNESKYICTKIHVTNHTEYHGCLQ 347

Query: 122 IQDLDTTDTGYYQCVATN--GMKTITATGVLFVRLGPTHSPNHNFQDDYHED 171
           + +    + G Y  +A N  G      +       G     N N+ D  +ED
Sbjct: 348 LDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYED 399


>gi|59889560 neurotrophic tyrosine kinase, receptor, type 3 isoform
           b precursor [Homo sapiens]
          Length = 825

 Score =  246 bits (627), Expect = 9e-65
 Identities = 127/294 (43%), Positives = 176/294 (59%), Gaps = 2/294 (0%)

Query: 458 NQHK-QAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGP 516
           N HK    ++ I    +    ELGE  FGKV+    +  +P +    VA+K LKD     
Sbjct: 522 NCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAA 581

Query: 517 LREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGS 576
            R++F+ EA L   LQH ++V   GV     PL M+F Y  HGDL++FL    P + +  
Sbjct: 582 -RKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILV 640

Query: 577 TDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGL 636
               R  K  L     +H+ +QIA+GM YL+S H VH+DLATRN LV   L VKI D G+
Sbjct: 641 DGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGM 700

Query: 637 FREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGY 696
            R+VY+ DYY++ G+++LPIRWM PE+IMY KF+ +SD+WS+GV+LWE+F+YG QP+   
Sbjct: 701 SRDVYSTDYYRVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVILWEIFTYGKQPWFQL 760

Query: 697 SNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAWG 750
           SN +V+E I   +VL  P  CP  VY +M+ CW   P +R   K+I+  L A G
Sbjct: 761 SNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEIYKILHALG 814



 Score = 35.8 bits (81), Expect = 0.19
 Identities = 20/88 (22%), Positives = 41/88 (46%), Gaps = 1/88 (1%)

Query: 70  NITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTD 129
           N+T+ +G  A++ C  +G+P P+V W+      +   +  +     +   L + ++ + D
Sbjct: 218 NLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSED 277

Query: 130 TGY-YQCVATNGMKTITATGVLFVRLGP 156
            G+   C+A N +    A+  L V   P
Sbjct: 278 NGFTLTCIAENVVGMSNASVALTVYYPP 305



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 23/88 (26%), Positives = 38/88 (43%), Gaps = 8/88 (9%)

Query: 67  PVNNITIVQGQTAILHC---KVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYG----SR 119
           P   +++ + +  + HC    V GNPPP + WL N  P ++E + I +   + G      
Sbjct: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQP-LRESKIIHVEYYQEGEISEGC 362

Query: 120 LRIQDLDTTDTGYYQCVATNGMKTITAT 147
           L        + G Y  +A N + T   T
Sbjct: 363 LLFNKPTHYNNGNYTLIAKNPLGTANQT 390


>gi|59889562 neurotrophic tyrosine kinase, receptor, type 3 isoform
           a precursor [Homo sapiens]
          Length = 839

 Score =  239 bits (609), Expect = 1e-62
 Identities = 128/308 (41%), Positives = 176/308 (57%), Gaps = 16/308 (5%)

Query: 458 NQHK-QAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGP 516
           N HK    ++ I    +    ELGE  FGKV+    +  +P +    VA+K LKD     
Sbjct: 522 NCHKPDTYVQHIKRRDIVLKRELGEGAFGKVFLAECYNLSPTKDKMLVAVKALKDPTLAA 581

Query: 517 LREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGS 576
            R++F+ EA L   LQH ++V   GV     PL M+F Y  HGDL++FL    P + +  
Sbjct: 582 -RKDFQREAELLTNLQHEHIVKFYGVCGDGDPLIMVFEYMKHGDLNKFLRAHGPDAMILV 640

Query: 577 TDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGL 636
               R  K  L     +H+ +QIA+GM YL+S H VH+DLATRN LV   L VKI D G+
Sbjct: 641 DGQPRQAKGELGLSQMLHIASQIASGMVYLASQHFVHRDLATRNCLVGANLLVKIGDFGM 700

Query: 637 FREVYAADYYKLL--------------GNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVL 682
            R+VY+ DYY+L               G+++LPIRWM PE+IMY KF+ +SD+WS+GV+L
Sbjct: 701 SRDVYSTDYYRLFNPSGNDFCIWCEVGGHTMLPIRWMPPESIMYRKFTTESDVWSFGVIL 760

Query: 683 WEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDI 742
           WE+F+YG QP+   SN +V+E I   +VL  P  CP  VY +M+ CW   P +R   K+I
Sbjct: 761 WEIFTYGKQPWFQLSNTEVIECITQGRVLERPRVCPKEVYDVMLGCWQREPQQRLNIKEI 820

Query: 743 HSRLRAWG 750
           +  L A G
Sbjct: 821 YKILHALG 828



 Score = 35.8 bits (81), Expect = 0.19
 Identities = 20/88 (22%), Positives = 41/88 (46%), Gaps = 1/88 (1%)

Query: 70  NITIVQGQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTD 129
           N+T+ +G  A++ C  +G+P P+V W+      +   +  +     +   L + ++ + D
Sbjct: 218 NLTVREGDNAVITCNGSGSPLPDVDWIVTGLQSINTHQTNLNWTNVHAINLTLVNVTSED 277

Query: 130 TGY-YQCVATNGMKTITATGVLFVRLGP 156
            G+   C+A N +    A+  L V   P
Sbjct: 278 NGFTLTCIAENVVGMSNASVALTVYYPP 305



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 23/88 (26%), Positives = 38/88 (43%), Gaps = 8/88 (9%)

Query: 67  PVNNITIVQGQTAILHC---KVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYG----SR 119
           P   +++ + +  + HC    V GNPPP + WL N  P ++E + I +   + G      
Sbjct: 304 PPRVVSLEEPELRLEHCIEFVVRGNPPPTLHWLHNGQP-LRESKIIHVEYYQEGEISEGC 362

Query: 120 LRIQDLDTTDTGYYQCVATNGMKTITAT 147
           L        + G Y  +A N + T   T
Sbjct: 363 LLFNKPTHYNNGNYTLIAKNPLGTANQT 390


>gi|59889558 neurotrophic tyrosine kinase, receptor, type 1 isoform
           1 [Homo sapiens]
          Length = 790

 Score =  238 bits (607), Expect = 2e-62
 Identities = 119/271 (43%), Positives = 169/271 (62%), Gaps = 2/271 (0%)

Query: 478 ELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVV 537
           ELGE  FGKV+        P +    VA+K LK+ +E   R++F+ EA L   LQH ++V
Sbjct: 509 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA-RQDFQREAELLTMLQHQHIV 567

Query: 538 CLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVA 597
              GV T+ +PL M+F Y  HGDL+ FL    P + + +  +D      L     + + +
Sbjct: 568 RFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGED-VAPGPLGLGQLLAVAS 626

Query: 598 QIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIR 657
           Q+AAGM YL+  H VH+DLATRN LV   L VKI D G+ R++Y+ DYY++ G ++LPIR
Sbjct: 627 QVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIR 686

Query: 658 WMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDC 717
           WM PE+I+Y KF+ +SD+WS+GVVLWE+F+YG QP+   SN + ++ I   + L  P  C
Sbjct: 687 WMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRAC 746

Query: 718 PAWVYALMIECWNEFPSRRPRFKDIHSRLRA 748
           P  VYA+M  CW   P +R   KD+H+RL+A
Sbjct: 747 PPEVYAIMRGCWQREPQQRHSIKDVHARLQA 777


>gi|4585712 neurotrophic tyrosine kinase, receptor, type 1 isoform 2
           [Homo sapiens]
          Length = 796

 Score =  238 bits (607), Expect = 2e-62
 Identities = 119/271 (43%), Positives = 169/271 (62%), Gaps = 2/271 (0%)

Query: 478 ELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVV 537
           ELGE  FGKV+        P +    VA+K LK+ +E   R++F+ EA L   LQH ++V
Sbjct: 515 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA-RQDFQREAELLTMLQHQHIV 573

Query: 538 CLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVA 597
              GV T+ +PL M+F Y  HGDL+ FL    P + + +  +D      L     + + +
Sbjct: 574 RFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGED-VAPGPLGLGQLLAVAS 632

Query: 598 QIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIR 657
           Q+AAGM YL+  H VH+DLATRN LV   L VKI D G+ R++Y+ DYY++ G ++LPIR
Sbjct: 633 QVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIR 692

Query: 658 WMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDC 717
           WM PE+I+Y KF+ +SD+WS+GVVLWE+F+YG QP+   SN + ++ I   + L  P  C
Sbjct: 693 WMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRAC 752

Query: 718 PAWVYALMIECWNEFPSRRPRFKDIHSRLRA 748
           P  VYA+M  CW   P +R   KD+H+RL+A
Sbjct: 753 PPEVYAIMRGCWQREPQQRHSIKDVHARLQA 783


>gi|56118210 neurotrophic tyrosine kinase, receptor, type 1 isoform
           3 [Homo sapiens]
          Length = 760

 Score =  238 bits (607), Expect = 2e-62
 Identities = 119/271 (43%), Positives = 169/271 (62%), Gaps = 2/271 (0%)

Query: 478 ELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAMLRARLQHPNVV 537
           ELGE  FGKV+        P +    VA+K LK+ +E   R++F+ EA L   LQH ++V
Sbjct: 479 ELGEGAFGKVFLAECHNLLPEQDKMLVAVKALKEASESA-RQDFQREAELLTMLQHQHIV 537

Query: 538 CLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHLVA 597
              GV T+ +PL M+F Y  HGDL+ FL    P + + +  +D      L     + + +
Sbjct: 538 RFFGVCTEGRPLLMVFEYMRHGDLNRFLRSHGPDAKLLAGGED-VAPGPLGLGQLLAVAS 596

Query: 598 QIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLPIR 657
           Q+AAGM YL+  H VH+DLATRN LV   L VKI D G+ R++Y+ DYY++ G ++LPIR
Sbjct: 597 QVAAGMVYLAGLHFVHRDLATRNCLVGQGLVVKIGDFGMSRDIYSTDYYRVGGRTMLPIR 656

Query: 658 WMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDC 717
           WM PE+I+Y KF+ +SD+WS+GVVLWE+F+YG QP+   SN + ++ I   + L  P  C
Sbjct: 657 WMPPESILYRKFTTESDVWSFGVVLWEIFTYGKQPWYQLSNTEAIDCITQGRELERPRAC 716

Query: 718 PAWVYALMIECWNEFPSRRPRFKDIHSRLRA 748
           P  VYA+M  CW   P +R   KD+H+RL+A
Sbjct: 717 PPEVYAIMRGCWQREPQQRHSIKDVHARLQA 747


>gi|4758284 ephrin receptor EphB1 precursor [Homo sapiens]
          Length = 984

 Score =  206 bits (523), Expect = 1e-52
 Identities = 122/287 (42%), Positives = 163/287 (56%), Gaps = 26/287 (9%)

Query: 466 KEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEA 525
           KEI +S V+  E +G   FG+VYKG L    PG++   VAIKTLK       R +F  EA
Sbjct: 612 KEIDVSFVKIEEVIGAGEFGEVYKGRL--KLPGKREIYVAIKTLKAGYSEKQRRDFLSEA 669

Query: 526 MLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKS 585
            +  +  HPN++ L GVVTK +P+ +I  +  +G L  FL            D   TV  
Sbjct: 670 SIMGQFDHPNIIRLEGVVTKSRPVMIITEFMENGALDSFL---------RQNDGQFTVIQ 720

Query: 586 ALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAAD- 644
                  V ++  IAAGM+YL+  + VH+DLA RN+LV   L  K+SD GL R  Y  D 
Sbjct: 721 ------LVGMLRGIAAGMKYLAEMNYVHRDLAARNILVNSNLVCKVSDFGLSR--YLQDD 772

Query: 645 -----YYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQ 699
                Y   LG  + P+RW APEAI Y KF+  SD+WSYG+V+WEV S+G +PY   SNQ
Sbjct: 773 TSDPTYTSSLGGKI-PVRWTAPEAIAYRKFTSASDVWSYGIVMWEVMSFGERPYWDMSNQ 831

Query: 700 DVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRL 746
           DV+  I     LP P DCPA ++ LM++CW +  + RPRF +I + L
Sbjct: 832 DVINAIEQDYRLPPPMDCPAALHQLMLDCWQKDRNSRPRFAEIVNTL 878


>gi|119395738 insulin receptor isoform Short precursor [Homo sapiens]
          Length = 1370

 Score =  205 bits (521), Expect = 2e-52
 Identities = 110/281 (39%), Positives = 159/281 (56%), Gaps = 6/281 (2%)

Query: 467  EISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAM 526
            E+S   +  + ELG+  FG VY+G+      GE    VA+KT+ + A    R EF +EA 
Sbjct: 1005 EVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEAS 1064

Query: 527  LRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSA 586
            +       +VV LLGVV+K QP  ++    +HGDL  +L    P ++        T++  
Sbjct: 1065 VMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQ-- 1122

Query: 587  LEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYY 646
                + + + A+IA GM YL++   VH+DLA RN +V     VKI D G+ R++Y  DYY
Sbjct: 1123 ----EMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYY 1178

Query: 647  KLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIR 706
            +  G  LLP+RWMAPE++  G F+  SD+WS+GVVLWE+ S   QPY G SN+ V++ + 
Sbjct: 1179 RKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVM 1238

Query: 707  NRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLR 747
            +   L  PD+CP  V  LM  CW   P  RP F +I + L+
Sbjct: 1239 DGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLK 1279


>gi|119395736 insulin receptor isoform Long precursor [Homo sapiens]
          Length = 1382

 Score =  205 bits (521), Expect = 2e-52
 Identities = 110/281 (39%), Positives = 159/281 (56%), Gaps = 6/281 (2%)

Query: 467  EISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAM 526
            E+S   +  + ELG+  FG VY+G+      GE    VA+KT+ + A    R EF +EA 
Sbjct: 1017 EVSREKITLLRELGQGSFGMVYEGNARDIIKGEAETRVAVKTVNESASLRERIEFLNEAS 1076

Query: 527  LRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSA 586
            +       +VV LLGVV+K QP  ++    +HGDL  +L    P ++        T++  
Sbjct: 1077 VMKGFTCHHVVRLLGVVSKGQPTLVVMELMAHGDLKSYLRSLRPEAENNPGRPPPTLQ-- 1134

Query: 587  LEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYY 646
                + + + A+IA GM YL++   VH+DLA RN +V     VKI D G+ R++Y  DYY
Sbjct: 1135 ----EMIQMAAEIADGMAYLNAKKFVHRDLAARNCMVAHDFTVKIGDFGMTRDIYETDYY 1190

Query: 647  KLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIR 706
            +  G  LLP+RWMAPE++  G F+  SD+WS+GVVLWE+ S   QPY G SN+ V++ + 
Sbjct: 1191 RKGGKGLLPVRWMAPESLKDGVFTTSSDMWSFGVVLWEITSLAEQPYQGLSNEQVLKFVM 1250

Query: 707  NRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLR 747
            +   L  PD+CP  V  LM  CW   P  RP F +I + L+
Sbjct: 1251 DGGYLDQPDNCPERVTDLMRMCWQFNPKMRPTFLEIVNLLK 1291


>gi|62420886 discoidin domain receptor family, member 2 precursor
           [Homo sapiens]
          Length = 855

 Score =  204 bits (520), Expect = 2e-52
 Identities = 119/310 (38%), Positives = 172/310 (55%), Gaps = 25/310 (8%)

Query: 461 KQAKLKEISLSAVRFMEELGEDRFGKVYKGHLFG-----------PAPGEQTQAVAIKTL 509
           K   ++E     + F E+LGE +FG+V+   + G                Q   VA+K L
Sbjct: 551 KDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKML 610

Query: 510 KDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRS 569
           +  A    R +F  E  + +RL+ PN++ LL V   D PL MI  Y  +GDL++FL    
Sbjct: 611 RADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHE 670

Query: 570 PHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNV 629
           P +   S+ D RTV       +   +  QIA+GM+YLSS + VH+DLATRN LV     +
Sbjct: 671 PPNS--SSSDVRTVSYT----NLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTI 724

Query: 630 KISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSY- 688
           KI+D G+ R +Y+ DYY++ G ++LPIRWM+ E+I+ GKF+  SD+W++GV LWE F++ 
Sbjct: 725 KIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFC 784

Query: 689 GLQPYCGYSNQDVVEMI------RNRQV-LPCPDDCPAWVYALMIECWNEFPSRRPRFKD 741
             QPY   S++ V+E        + RQ  LP P  CP  VY LM+ CW      RP F++
Sbjct: 785 QEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQE 844

Query: 742 IHSRLRAWGN 751
           IH  L   G+
Sbjct: 845 IHLLLLQQGD 854


>gi|62420884 discoidin domain receptor family, member 2 precursor
           [Homo sapiens]
          Length = 855

 Score =  204 bits (520), Expect = 2e-52
 Identities = 119/310 (38%), Positives = 172/310 (55%), Gaps = 25/310 (8%)

Query: 461 KQAKLKEISLSAVRFMEELGEDRFGKVYKGHLFG-----------PAPGEQTQAVAIKTL 509
           K   ++E     + F E+LGE +FG+V+   + G                Q   VA+K L
Sbjct: 551 KDVAVEEFPRKLLTFKEKLGEGQFGEVHLCEVEGMEKFKDKDFALDVSANQPVLVAVKML 610

Query: 510 KDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRS 569
           +  A    R +F  E  + +RL+ PN++ LL V   D PL MI  Y  +GDL++FL    
Sbjct: 611 RADANKNARNDFLKEIKIMSRLKDPNIIHLLAVCITDDPLCMITEYMENGDLNQFLSRHE 670

Query: 570 PHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNV 629
           P +   S+ D RTV       +   +  QIA+GM+YLSS + VH+DLATRN LV     +
Sbjct: 671 PPNS--SSSDVRTVSYT----NLKFMATQIASGMKYLSSLNFVHRDLATRNCLVGKNYTI 724

Query: 630 KISDLGLFREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSY- 688
           KI+D G+ R +Y+ DYY++ G ++LPIRWM+ E+I+ GKF+  SD+W++GV LWE F++ 
Sbjct: 725 KIADFGMSRNLYSGDYYRIQGRAVLPIRWMSWESILLGKFTTASDVWAFGVTLWETFTFC 784

Query: 689 GLQPYCGYSNQDVVEMI------RNRQV-LPCPDDCPAWVYALMIECWNEFPSRRPRFKD 741
             QPY   S++ V+E        + RQ  LP P  CP  VY LM+ CW      RP F++
Sbjct: 785 QEQPYSQLSDEQVIENTGEFFRDQGRQTYLPQPAICPDSVYKLMLSCWRRDTKNRPSFQE 844

Query: 742 IHSRLRAWGN 751
           IH  L   G+
Sbjct: 845 IHLLLLQQGD 854


>gi|111118978 ephrin receptor EphB2 isoform 1 precursor [Homo
           sapiens]
          Length = 986

 Score =  204 bits (519), Expect = 3e-52
 Identities = 127/344 (36%), Positives = 178/344 (51%), Gaps = 31/344 (9%)

Query: 416 LVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEMPLI---------NQHKQAKLK 466
           L+   +  +VC  R  ++A +    + Q   S      M +          N+  +   K
Sbjct: 555 LIAVVVIAIVCNRRGFERADSEYTDKLQHYTSGHMTPGMKIYIDPFTYEDPNEAVREFAK 614

Query: 467 EISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAM 526
           EI +S V+  + +G   FG+V  GHL    PG++   VAIKTLK       R +F  EA 
Sbjct: 615 EIDISCVKIEQVIGAGEFGEVCSGHL--KLPGKREIFVAIKTLKSGYTEKQRRDFLSEAS 672

Query: 527 LRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSA 586
           +  +  HPNV+ L GVVTK  P+ +I  +  +G L  FL            D   TV   
Sbjct: 673 IMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFL---------RQNDGQFTVIQ- 722

Query: 587 LEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFR----EVYA 642
                 V ++  IAAGM+YL+  + VH+DLA RN+LV   L  K+SD GL R    +   
Sbjct: 723 -----LVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTSD 777

Query: 643 ADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVV 702
             Y   LG  + PIRW APEAI Y KF+  SD+WSYG+V+WEV SYG +PY   +NQDV+
Sbjct: 778 PTYTSALGGKI-PIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDVI 836

Query: 703 EMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRL 746
             I     LP P DCP+ ++ LM++CW +  + RP+F  I + L
Sbjct: 837 NAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTL 880


>gi|4758280 ephrin receptor EphA4 [Homo sapiens]
          Length = 986

 Score =  203 bits (517), Expect = 5e-52
 Identities = 138/392 (35%), Positives = 195/392 (49%), Gaps = 26/392 (6%)

Query: 391 VPSCSPRDSSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQ 450
           VPS    D +   +L + V    + +VI    F++   R+K   +       + +    +
Sbjct: 535 VPSRIIGDGANSTVLLVSVSGSVVLVVILIAAFVISRRRSKYSKAKQEADEEKHLNQGVR 594

Query: 451 DMEMPLI----NQHKQAKLKEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAI 506
               P      NQ  +   KEI  S ++  + +G   FG+V  G L    PG++   VAI
Sbjct: 595 TYVDPFTYEDPNQAVREFAKEIDASCIKIEKVIGVGEFGEVCSGRL--KVPGKREICVAI 652

Query: 507 KTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLV 566
           KTLK       R +F  EA +  +  HPN++ L GVVTK +P+ +I  Y  +G L  FL 
Sbjct: 653 KTLKAGYTDKQRRDFLSEASIMGQFDHPNIIHLEGVVTKCKPVMIITEYMENGSLDAFL- 711

Query: 567 MRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDK 626
                      +D R     L     V ++  I +GM+YLS    VH+DLA RN+LV   
Sbjct: 712 ---------RKNDGRFTVIQL-----VGMLRGIGSGMKYLSDMSYVHRDLAARNILVNSN 757

Query: 627 LNVKISDLGLFR--EVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWE 684
           L  K+SD G+ R  E      Y   G  + PIRW APEAI Y KF+  SD+WSYG+V+WE
Sbjct: 758 LVCKVSDFGMSRVLEDDPEAAYTTRGGKI-PIRWTAPEAIAYRKFTSASDVWSYGIVMWE 816

Query: 685 VFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHS 744
           V SYG +PY   SNQDV++ I     LP P DCP  ++ LM++CW +  S RP+F  I +
Sbjct: 817 VMSYGERPYWDMSNQDVIKAIEEGYRLPPPMDCPIALHQLMLDCWQKERSDRPKFGQIVN 876

Query: 745 RLRAWGNLSNYNSSAQTSGASNTTQTSSLSTS 776
            L     + N NS  +T   S+   T+ L  S
Sbjct: 877 MLDKL--IRNPNSLKRTGTESSRPNTALLDPS 906


>gi|21396504 ephrin receptor EphB2 isoform 2 precursor [Homo
           sapiens]
          Length = 987

 Score =  202 bits (515), Expect = 9e-52
 Identities = 118/285 (41%), Positives = 159/285 (55%), Gaps = 22/285 (7%)

Query: 466 KEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEA 525
           KEI +S V+  + +G   FG+V  GHL    PG++   VAIKTLK       R +F  EA
Sbjct: 615 KEIDISCVKIEQVIGAGEFGEVCSGHL--KLPGKREIFVAIKTLKSGYTEKQRRDFLSEA 672

Query: 526 MLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKS 585
            +  +  HPNV+ L GVVTK  P+ +I  +  +G L  FL            D   TV  
Sbjct: 673 SIMGQFDHPNVIHLEGVVTKSTPVMIITEFMENGSLDSFL---------RQNDGQFTVIQ 723

Query: 586 ALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFR----EVY 641
                  V ++  IAAGM+YL+  + VH+DLA RN+LV   L  K+SD GL R    +  
Sbjct: 724 ------LVGMLRGIAAGMKYLADMNYVHRDLAARNILVNSNLVCKVSDFGLSRFLEDDTS 777

Query: 642 AADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDV 701
              Y   LG  + PIRW APEAI Y KF+  SD+WSYG+V+WEV SYG +PY   +NQDV
Sbjct: 778 DPTYTSALGGKI-PIRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMTNQDV 836

Query: 702 VEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRL 746
           +  I     LP P DCP+ ++ LM++CW +  + RP+F  I + L
Sbjct: 837 INAIEQDYRLPPPMDCPSALHQLMLDCWQKDRNHRPKFGQIVNTL 881


>gi|47524177 fibroblast growth factor receptor 4 isoform 2 precursor
           [Homo sapiens]
          Length = 762

 Score =  201 bits (510), Expect = 3e-51
 Identities = 107/267 (40%), Positives = 155/267 (58%), Gaps = 3/267 (1%)

Query: 479 LGEDRFGKVYKGHLFG--PAPGEQTQAVAIKTLKDKA-EGPLREEFRHEAMLRARLQHPN 535
           LGE  FG+V +   FG  PA  +Q   VA+K LKD A +  L +      +++   +H N
Sbjct: 433 LGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKN 492

Query: 536 VVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHL 595
           ++ LLGV T++ PL +I    + G+L EFL  R P     S D  R+ +  L  P  V  
Sbjct: 493 IINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSC 552

Query: 596 VAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLP 655
             Q+A GM+YL S   +H+DLA RNVLV +   +KI+D GL R V+  DYYK   N  LP
Sbjct: 553 AYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLP 612

Query: 656 IRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPD 715
           ++WMAPEA+    ++  SD+WS+G++LWE+F+ G  PY G   +++  ++R    +  P 
Sbjct: 613 VKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPP 672

Query: 716 DCPAWVYALMIECWNEFPSRRPRFKDI 742
            CP  +Y LM ECW+  PS+RP FK +
Sbjct: 673 HCPPELYGLMRECWHAAPSQRPTFKQL 699



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 27/85 (31%), Positives = 37/85 (43%)

Query: 76  GQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQC 135
           G T    C  AGNP P +RWLK+      E R   IR       L ++ +  +D G Y C
Sbjct: 165 GNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTC 224

Query: 136 VATNGMKTITATGVLFVRLGPTHSP 160
           +  N + +I    +L V     H P
Sbjct: 225 LVENAVGSIRYNYLLDVLERSPHRP 249



 Score = 35.0 bits (79), Expect = 0.33
 Identities = 24/83 (28%), Positives = 37/83 (44%), Gaps = 12/83 (14%)

Query: 70  NITIVQGQTAILHCKVAGNPPPNVRWLK-----------NDAPVVQEPRRIIIRKTEYGS 118
           N T V G    L CKV  +  P+++WLK           +  P VQ  +   I  +E   
Sbjct: 258 NTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEV-E 316

Query: 119 RLRIQDLDTTDTGYYQCVATNGM 141
            L ++++   D G Y C+A N +
Sbjct: 317 VLYLRNVSAEDAGEYTCLAGNSI 339


>gi|47524175 fibroblast growth factor receptor 4 isoform 1 precursor
           [Homo sapiens]
          Length = 802

 Score =  201 bits (510), Expect = 3e-51
 Identities = 107/267 (40%), Positives = 155/267 (58%), Gaps = 3/267 (1%)

Query: 479 LGEDRFGKVYKGHLFG--PAPGEQTQAVAIKTLKDKA-EGPLREEFRHEAMLRARLQHPN 535
           LGE  FG+V +   FG  PA  +Q   VA+K LKD A +  L +      +++   +H N
Sbjct: 473 LGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKN 532

Query: 536 VVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHL 595
           ++ LLGV T++ PL +I    + G+L EFL  R P     S D  R+ +  L  P  V  
Sbjct: 533 IINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSC 592

Query: 596 VAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLP 655
             Q+A GM+YL S   +H+DLA RNVLV +   +KI+D GL R V+  DYYK   N  LP
Sbjct: 593 AYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLP 652

Query: 656 IRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPD 715
           ++WMAPEA+    ++  SD+WS+G++LWE+F+ G  PY G   +++  ++R    +  P 
Sbjct: 653 VKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPP 712

Query: 716 DCPAWVYALMIECWNEFPSRRPRFKDI 742
            CP  +Y LM ECW+  PS+RP FK +
Sbjct: 713 HCPPELYGLMRECWHAAPSQRPTFKQL 739



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 27/85 (31%), Positives = 37/85 (43%)

Query: 76  GQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQC 135
           G T    C  AGNP P +RWLK+      E R   IR       L ++ +  +D G Y C
Sbjct: 165 GNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTC 224

Query: 136 VATNGMKTITATGVLFVRLGPTHSP 160
           +  N + +I    +L V     H P
Sbjct: 225 LVENAVGSIRYNYLLDVLERSPHRP 249



 Score = 35.0 bits (79), Expect = 0.33
 Identities = 24/83 (28%), Positives = 37/83 (44%), Gaps = 12/83 (14%)

Query: 70  NITIVQGQTAILHCKVAGNPPPNVRWLK-----------NDAPVVQEPRRIIIRKTEYGS 118
           N T V G    L CKV  +  P+++WLK           +  P VQ  +   I  +E   
Sbjct: 258 NTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEV-E 316

Query: 119 RLRIQDLDTTDTGYYQCVATNGM 141
            L ++++   D G Y C+A N +
Sbjct: 317 VLYLRNVSAEDAGEYTCLAGNSI 339


>gi|47524173 fibroblast growth factor receptor 4 isoform 1 precursor
           [Homo sapiens]
          Length = 802

 Score =  201 bits (510), Expect = 3e-51
 Identities = 107/267 (40%), Positives = 155/267 (58%), Gaps = 3/267 (1%)

Query: 479 LGEDRFGKVYKGHLFG--PAPGEQTQAVAIKTLKDKA-EGPLREEFRHEAMLRARLQHPN 535
           LGE  FG+V +   FG  PA  +Q   VA+K LKD A +  L +      +++   +H N
Sbjct: 473 LGEGCFGQVVRAEAFGMDPARPDQASTVAVKMLKDNASDKDLADLVSEMEVMKLIGRHKN 532

Query: 536 VVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSALEPPDFVHL 595
           ++ LLGV T++ PL +I    + G+L EFL  R P     S D  R+ +  L  P  V  
Sbjct: 533 IINLLGVCTQEGPLYVIVECAAKGNLREFLRARRPPGPDLSPDGPRSSEGPLSFPVLVSC 592

Query: 596 VAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYYKLLGNSLLP 655
             Q+A GM+YL S   +H+DLA RNVLV +   +KI+D GL R V+  DYYK   N  LP
Sbjct: 593 AYQVARGMQYLESRKCIHRDLAARNVLVTEDNVMKIADFGLARGVHHIDYYKKTSNGRLP 652

Query: 656 IRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIRNRQVLPCPD 715
           ++WMAPEA+    ++  SD+WS+G++LWE+F+ G  PY G   +++  ++R    +  P 
Sbjct: 653 VKWMAPEALFDRVYTHQSDVWSFGILLWEIFTLGGSPYPGIPVEELFSLLREGHRMDRPP 712

Query: 716 DCPAWVYALMIECWNEFPSRRPRFKDI 742
            CP  +Y LM ECW+  PS+RP FK +
Sbjct: 713 HCPPELYGLMRECWHAAPSQRPTFKQL 739



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 27/85 (31%), Positives = 37/85 (43%)

Query: 76  GQTAILHCKVAGNPPPNVRWLKNDAPVVQEPRRIIIRKTEYGSRLRIQDLDTTDTGYYQC 135
           G T    C  AGNP P +RWLK+      E R   IR       L ++ +  +D G Y C
Sbjct: 165 GNTVKFRCPAAGNPTPTIRWLKDGQAFHGENRIGGIRLRHQHWSLVMESVVPSDRGTYTC 224

Query: 136 VATNGMKTITATGVLFVRLGPTHSP 160
           +  N + +I    +L V     H P
Sbjct: 225 LVENAVGSIRYNYLLDVLERSPHRP 249



 Score = 35.0 bits (79), Expect = 0.33
 Identities = 24/83 (28%), Positives = 37/83 (44%), Gaps = 12/83 (14%)

Query: 70  NITIVQGQTAILHCKVAGNPPPNVRWLK-----------NDAPVVQEPRRIIIRKTEYGS 118
           N T V G    L CKV  +  P+++WLK           +  P VQ  +   I  +E   
Sbjct: 258 NTTAVVGSDVELLCKVYSDAQPHIQWLKHIVINGSSFGADGFPYVQVLKTADINSSEV-E 316

Query: 119 RLRIQDLDTTDTGYYQCVATNGM 141
            L ++++   D G Y C+A N +
Sbjct: 317 VLYLRNVSAEDAGEYTCLAGNSI 339


>gi|32528301 EPH receptor B4 precursor [Homo sapiens]
          Length = 987

 Score =  199 bits (506), Expect = 1e-50
 Identities = 118/285 (41%), Positives = 160/285 (56%), Gaps = 22/285 (7%)

Query: 466 KEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEA 525
           KEI +S V+  E +G   FG+V +G L   APG++   VAIKTLK       R EF  EA
Sbjct: 608 KEIDVSYVKIEEVIGAGEFGEVCRGRL--KAPGKKESCVAIKTLKGGYTERQRREFLSEA 665

Query: 526 MLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKS 585
            +  + +HPN++ L GVVT   P+ ++  +  +G L  FL +          D   TV  
Sbjct: 666 SIMGQFEHPNIIRLEGVVTNSMPVMILTEFMENGALDSFLRLN---------DGQFTVIQ 716

Query: 586 ALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGL--FREVYAA 643
                  V ++  IA+GM YL+    VH+DLA RN+LV   L  K+SD GL  F E  ++
Sbjct: 717 ------LVGMLRGIASGMRYLAEMSYVHRDLAARNILVNSNLVCKVSDFGLSRFLEENSS 770

Query: 644 D--YYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDV 701
           D  Y   LG  + PIRW APEAI + KF+  SD WSYG+V+WEV S+G +PY   SNQDV
Sbjct: 771 DPTYTSSLGGKI-PIRWTAPEAIAFRKFTSASDAWSYGIVMWEVMSFGERPYWDMSNQDV 829

Query: 702 VEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRL 746
           +  I     LP P DCP  ++ LM++CW +  + RPRF  + S L
Sbjct: 830 INAIEQDYRLPPPPDCPTSLHQLMLDCWQKDRNARPRFPQVVSAL 874


>gi|4557665 insulin-like growth factor 1 receptor precursor [Homo
            sapiens]
          Length = 1367

 Score =  198 bits (504), Expect = 2e-50
 Identities = 107/284 (37%), Positives = 155/284 (54%), Gaps = 12/284 (4%)

Query: 467  EISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAM 526
            E++   +    ELG+  FG VY+G   G    E    VAIKT+ + A    R EF +EA 
Sbjct: 993  EVAREKITMSRELGQGSFGMVYEGVAKGVVKDEPETRVAIKTVNEAASMRERIEFLNEAS 1052

Query: 527  LRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSA 586
            +       +VV LLGVV++ QP  +I    + GDL  +L    P  +             
Sbjct: 1053 VMKEFNCHHVVRLLGVVSQGQPTLVIMELMTRGDLKSYLRSLRPEMENNPV--------- 1103

Query: 587  LEPPDF---VHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAA 643
            L PP     + +  +IA GM YL+++  VH+DLA RN +V +   VKI D G+ R++Y  
Sbjct: 1104 LAPPSLSKMIQMAGEIADGMAYLNANKFVHRDLAARNCMVAEDFTVKIGDFGMTRDIYET 1163

Query: 644  DYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVE 703
            DYY+  G  LLP+RWM+PE++  G F+  SD+WS+GVVLWE+ +   QPY G SN+ V+ 
Sbjct: 1164 DYYRKGGKGLLPVRWMSPESLKDGVFTTYSDVWSFGVVLWEIATLAEQPYQGLSNEQVLR 1223

Query: 704  MIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLR 747
             +    +L  PD+CP  ++ LM  CW   P  RP F +I S ++
Sbjct: 1224 FVMEGGLLDKPDNCPDMLFELMRMCWQYNPKMRPSFLEIISSIK 1267


>gi|38327632 discoidin domain receptor family, member 1 isoform b
           [Homo sapiens]
          Length = 876

 Score =  198 bits (503), Expect = 2e-50
 Identities = 112/295 (37%), Positives = 166/295 (56%), Gaps = 22/295 (7%)

Query: 471 SAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQ-----------AVAIKTLKDKAEGPLRE 519
           S +RF E+LGE +FG+V+   +  P                   VA+K L+  A    R 
Sbjct: 571 SRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARN 630

Query: 520 EFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDV--GST 577
           +F  E  + +RL+ PN++ LLGV  +D PL MI  Y  +GDL++FL           G+ 
Sbjct: 631 DFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAP 690

Query: 578 DDDRTVKS-ALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGL 636
            D +  +   +  P  +H+ AQIA+GM YL++ + VH+DLATRN LV +   +KI+D G+
Sbjct: 691 GDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGM 750

Query: 637 FREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSY-GLQPYCG 695
            R +YA DYY++ G ++LPIRWMA E I+ GKF+  SD+W++GV LWEV      QP+  
Sbjct: 751 SRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQ 810

Query: 696 YSNQDVVEMI------RNRQV-LPCPDDCPAWVYALMIECWNEFPSRRPRFKDIH 743
            +++ V+E        + RQV L  P  CP  +Y LM+ CW+    +RP F  +H
Sbjct: 811 LTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLH 865


>gi|83977450 discoidin domain receptor family, member 1 isoform a
           [Homo sapiens]
          Length = 913

 Score =  198 bits (503), Expect = 2e-50
 Identities = 112/295 (37%), Positives = 166/295 (56%), Gaps = 22/295 (7%)

Query: 471 SAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQ-----------AVAIKTLKDKAEGPLRE 519
           S +RF E+LGE +FG+V+   +  P                   VA+K L+  A    R 
Sbjct: 608 SRLRFKEKLGEGQFGEVHLCEVDSPQDLVSLDFPLNVRKGHPLLVAVKILRPDATKNARN 667

Query: 520 EFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDV--GST 577
           +F  E  + +RL+ PN++ LLGV  +D PL MI  Y  +GDL++FL           G+ 
Sbjct: 668 DFLKEVKIMSRLKDPNIIRLLGVCVQDDPLCMITDYMENGDLNQFLSAHQLEDKAAEGAP 727

Query: 578 DDDRTVKS-ALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGL 636
            D +  +   +  P  +H+ AQIA+GM YL++ + VH+DLATRN LV +   +KI+D G+
Sbjct: 728 GDGQAAQGPTISYPMLLHVAAQIASGMRYLATLNFVHRDLATRNCLVGENFTIKIADFGM 787

Query: 637 FREVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSY-GLQPYCG 695
            R +YA DYY++ G ++LPIRWMA E I+ GKF+  SD+W++GV LWEV      QP+  
Sbjct: 788 SRNLYAGDYYRVQGRAVLPIRWMAWECILMGKFTTASDVWAFGVTLWEVLMLCRAQPFGQ 847

Query: 696 YSNQDVVEMI------RNRQV-LPCPDDCPAWVYALMIECWNEFPSRRPRFKDIH 743
            +++ V+E        + RQV L  P  CP  +Y LM+ CW+    +RP F  +H
Sbjct: 848 LTDEQVIENAGEFFRDQGRQVYLSRPPACPQGLYELMLRCWSRESEQRPPFSQLH 902


>gi|27886593 PTK2 protein tyrosine kinase 2 isoform b [Homo sapiens]
          Length = 1074

 Score =  197 bits (502), Expect = 3e-50
 Identities = 119/359 (33%), Positives = 177/359 (49%), Gaps = 31/359 (8%)

Query: 467 EISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAM 526
           EI    +     +GE +FG V++G    P       AVAIKT K+     +RE+F  EA+
Sbjct: 438 EIQRERIELGRCIGEGQFGDVHQGIYMSPE--NPALAVAIKTCKNCTSDSVREKFLQEAL 495

Query: 527 LRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSA 586
              +  HP++V L+GV+T++ P+ +I   C+ G+L  FL +R               K +
Sbjct: 496 TMRQFDHPHIVKLIGVITEN-PVWIIMELCTLGELRSFLQVR---------------KYS 539

Query: 587 LEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYY 646
           L+    +    Q++  + YL S   VH+D+A RNVLV     VK+ D GL R +  + YY
Sbjct: 540 LDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYY 599

Query: 647 KLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIR 706
           K      LPI+WMAPE+I + +F+  SD+W +GV +WE+  +G++P+ G  N DV+  I 
Sbjct: 600 KA-SKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIE 658

Query: 707 NRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASN 766
           N + LP P +CP  +Y+LM +CW   PSRRPRF ++ ++L             +    S 
Sbjct: 659 NGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESR 718

Query: 767 TTQTSSLSTSPVSNVSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQ 825
              T S  +            G   +APP P     P         P PQ  V  N YQ
Sbjct: 719 RQATVSWDS------------GGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQ 765


>gi|24476013 PTK2 protein tyrosine kinase 2 isoform a [Homo sapiens]
          Length = 1052

 Score =  197 bits (502), Expect = 3e-50
 Identities = 119/359 (33%), Positives = 177/359 (49%), Gaps = 31/359 (8%)

Query: 467 EISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEAM 526
           EI    +     +GE +FG V++G    P       AVAIKT K+     +RE+F  EA+
Sbjct: 416 EIQRERIELGRCIGEGQFGDVHQGIYMSPE--NPALAVAIKTCKNCTSDSVREKFLQEAL 473

Query: 527 LRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKSA 586
              +  HP++V L+GV+T++ P+ +I   C+ G+L  FL +R               K +
Sbjct: 474 TMRQFDHPHIVKLIGVITEN-PVWIIMELCTLGELRSFLQVR---------------KYS 517

Query: 587 LEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVYAADYY 646
           L+    +    Q++  + YL S   VH+D+A RNVLV     VK+ D GL R +  + YY
Sbjct: 518 LDLASLILYAYQLSTALAYLESKRFVHRDIAARNVLVSSNDCVKLGDFGLSRYMEDSTYY 577

Query: 647 KLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVEMIR 706
           K      LPI+WMAPE+I + +F+  SD+W +GV +WE+  +G++P+ G  N DV+  I 
Sbjct: 578 KA-SKGKLPIKWMAPESINFRRFTSASDVWMFGVCMWEILMHGVKPFQGVKNNDVIGRIE 636

Query: 707 NRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHSRLRAWGNLSNYNSSAQTSGASN 766
           N + LP P +CP  +Y+LM +CW   PSRRPRF ++ ++L             +    S 
Sbjct: 637 NGERLPMPPNCPPTLYSLMTKCWAYDPSRRPRFTELKAQLSTILEEEKAQQEERMRMESR 696

Query: 767 TTQTSSLSTSPVSNVSNARYVGPKQKAPPFPQPQFIPMKGQIRPMVPPPQLYVPVNGYQ 825
              T S  +            G   +APP P     P         P PQ  V  N YQ
Sbjct: 697 RQATVSWDS------------GGSDEAPPKPSRPGYPSPRSSEGFYPSPQHMVQTNHYQ 743


>gi|32967311 ephrin receptor EphA2 [Homo sapiens]
          Length = 976

 Score =  197 bits (501), Expect = 4e-50
 Identities = 131/362 (36%), Positives = 190/362 (52%), Gaps = 28/362 (7%)

Query: 395 SPRDSSKMGILYILVPSIAIPLVIACLFFLVCMCRNKQKASASTPQRRQLMASPSQDMEM 454
           SP  S  + ++  +   + + LV+A + F +   R  Q+A  S P+      S       
Sbjct: 528 SPEGSGNLAVIGGVAVGVVLLLVLAGVGFFIHRRRKNQRARQS-PEDVYFSKSEQLKPLK 586

Query: 455 PLINQH-----KQAKLK---EISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAI 506
             ++ H      QA LK   EI  S V   + +G   FG+VYKG L   + G++   VAI
Sbjct: 587 TYVDPHTYEDPNQAVLKFTTEIHPSCVTRQKVIGAGEFGEVYKGML-KTSSGKKEVPVAI 645

Query: 507 KTLKDKAEGPLREEFRHEAMLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLV 566
           KTLK       R +F  EA +  +  H N++ L GV++K +P+ +I  Y  +G L +FL 
Sbjct: 646 KTLKAGYTEKQRVDFLGEAGIMGQFSHHNIIRLEGVISKYKPMMIITEYMENGALDKFL- 704

Query: 567 MRSPHSDVGSTDDDRTVKSALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDK 626
                         R           V ++  IAAGM+YL++ + VH+DLA RN+LV   
Sbjct: 705 --------------REKDGEFSVLQLVGMLRGIAAGMKYLANMNYVHRDLAARNILVNSN 750

Query: 627 LNVKISDLGLFR--EVYAADYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWE 684
           L  K+SD GL R  E      Y   G  + PIRW APEAI Y KF+  SD+WS+G+V+WE
Sbjct: 751 LVCKVSDFGLSRVLEDDPEATYTTSGGKI-PIRWTAPEAISYRKFTSASDVWSFGIVMWE 809

Query: 685 VFSYGLQPYCGYSNQDVVEMIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDIHS 744
           V +YG +PY   SN +V++ I +   LP P DCP+ +Y LM++CW +  +RRP+F DI S
Sbjct: 810 VMTYGERPYWELSNHEVMKAINDGFRLPTPMDCPSAIYQLMMQCWQQERARRPKFADIVS 869

Query: 745 RL 746
            L
Sbjct: 870 IL 871


>gi|4758282 ephrin receptor EphA7 [Homo sapiens]
          Length = 998

 Score =  197 bits (500), Expect = 5e-50
 Identities = 114/279 (40%), Positives = 155/279 (55%), Gaps = 20/279 (7%)

Query: 466 KEISLSAVRFMEELGEDRFGKVYKGHLFGPAPGEQTQAVAIKTLKDKAEGPLREEFRHEA 525
           KE+  S ++    +G   FG+V  G L    PG++  AVAIKTLK       R +F  EA
Sbjct: 626 KELDASCIKIERVIGAGEFGEVCSGRL--KLPGKRDVAVAIKTLKVGYTEKQRRDFLCEA 683

Query: 526 MLRARLQHPNVVCLLGVVTKDQPLSMIFSYCSHGDLHEFLVMRSPHSDVGSTDDDRTVKS 585
            +  +  HPNVV L GVVT+ +P+ ++  +  +G L  FL            D   TV  
Sbjct: 684 SIMGQFDHPNVVHLEGVVTRGKPVMIVIEFMENGALDAFLRKH---------DGQFTVIQ 734

Query: 586 ALEPPDFVHLVAQIAAGMEYLSSHHVVHKDLATRNVLVYDKLNVKISDLGLFREVY--AA 643
                  V ++  IAAGM YL+    VH+DLA RN+LV   L  K+SD GL R +     
Sbjct: 735 ------LVGMLRGIAAGMRYLADMGYVHRDLAARNILVNSNLVCKVSDFGLSRVIEDDPE 788

Query: 644 DYYKLLGNSLLPIRWMAPEAIMYGKFSIDSDIWSYGVVLWEVFSYGLQPYCGYSNQDVVE 703
             Y   G  + P+RW APEAI Y KF+  SD+WSYG+V+WEV SYG +PY   SNQDV++
Sbjct: 789 AVYTTTGGKI-PVRWTAPEAIQYRKFTSASDVWSYGIVMWEVMSYGERPYWDMSNQDVIK 847

Query: 704 MIRNRQVLPCPDDCPAWVYALMIECWNEFPSRRPRFKDI 742
            I     LP P DCPA ++ LM++CW +  + RP+F+ I
Sbjct: 848 AIEEGYRLPAPMDCPAGLHQLMLDCWQKERAERPKFEQI 886


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.319    0.135    0.419 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,774,417
Number of Sequences: 37866
Number of extensions: 2106652
Number of successful extensions: 12140
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 694
Number of HSP's successfully gapped in prelim test: 533
Number of HSP's that attempted gapping in prelim test: 7685
Number of HSP's gapped (non-prelim): 3166
length of query: 943
length of database: 18,247,518
effective HSP length: 112
effective length of query: 831
effective length of database: 14,006,526
effective search space: 11639423106
effective search space used: 11639423106
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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