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Search of human proteins with 195972883
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens]
(777 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens] 1576 0.0
gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens] 1516 0.0
gi|19115964 phospholipase C delta 3 [Homo sapiens] 760 0.0
gi|14249340 phospholipase C, delta 4 [Homo sapiens] 689 0.0
gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens] 484 e-136
gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens] 484 e-136
gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens] 466 e-131
gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens] 466 e-131
gi|25188201 phospholipase C, zeta 1 [Homo sapiens] 460 e-129
gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens] 360 4e-99
gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens] 360 4e-99
gi|12083581 phosphoinositide-specific phospholipase C beta 1 iso... 328 2e-89
gi|33356544 phosphoinositide-specific phospholipase C beta 1 iso... 328 2e-89
gi|95147333 phospholipase C, beta 2 [Homo sapiens] 322 8e-88
gi|78499633 phospholipase C, eta 2 [Homo sapiens] 303 3e-82
gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens] 293 4e-79
gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens] 293 4e-79
gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens] 293 4e-79
gi|11386139 phospholipase C beta 3 [Homo sapiens] 291 2e-78
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 241 2e-63
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 224 2e-58
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 224 2e-58
gi|117168250 phospholipase C, epsilon 1 [Homo sapiens] 219 1e-56
gi|209447073 synaptotagmin I [Homo sapiens] 45 3e-04
gi|5032139 synaptotagmin I [Homo sapiens] 45 3e-04
gi|209447070 synaptotagmin I [Homo sapiens] 45 3e-04
gi|21361472 neural precursor cell expressed, developmentally dow... 44 6e-04
gi|222352090 neural precursor cell expressed, developmentally do... 44 6e-04
gi|222352088 neural precursor cell expressed, developmentally do... 44 6e-04
gi|222352086 neural precursor cell expressed, developmentally do... 44 6e-04
>gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens]
Length = 777
Score = 1576 bits (4081), Expect = 0.0
Identities = 777/777 (100%), Positives = 777/777 (100%)
Query: 1 MQCLGIRSRSRSRELYLQERSLKVAALNGRRLGLQDDEDLQALLKGSQLLKVKSSSWRRE 60
MQCLGIRSRSRSRELYLQERSLKVAALNGRRLGLQDDEDLQALLKGSQLLKVKSSSWRRE
Sbjct: 1 MQCLGIRSRSRSRELYLQERSLKVAALNGRRLGLQDDEDLQALLKGSQLLKVKSSSWRRE 60
Query: 61 RFYKLQEDCKTIWQESRKVMRTPESQLFSIEDIQEVRMGHRTEGLEKFARDVPEDRCFSI 120
RFYKLQEDCKTIWQESRKVMRTPESQLFSIEDIQEVRMGHRTEGLEKFARDVPEDRCFSI
Sbjct: 61 RFYKLQEDCKTIWQESRKVMRTPESQLFSIEDIQEVRMGHRTEGLEKFARDVPEDRCFSI 120
Query: 121 VFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNK 180
VFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNK
Sbjct: 121 VFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNK 180
Query: 181 MSFKELQNFLKELNIQVDDSYARKIFRECDHSQTDSLEDEEIEAFYKMLTQRVEIDRTFA 240
MSFKELQNFLKELNIQVDDSYARKIFRECDHSQTDSLEDEEIEAFYKMLTQRVEIDRTFA
Sbjct: 181 MSFKELQNFLKELNIQVDDSYARKIFRECDHSQTDSLEDEEIEAFYKMLTQRVEIDRTFA 240
Query: 241 EAAGSGETLSVDQLVTFLQHQQREEAAGPALALSLIERYEPSETAKAQRQMTKDGFLMYL 300
EAAGSGETLSVDQLVTFLQHQQREEAAGPALALSLIERYEPSETAKAQRQMTKDGFLMYL
Sbjct: 241 EAAGSGETLSVDQLVTFLQHQQREEAAGPALALSLIERYEPSETAKAQRQMTKDGFLMYL 300
Query: 301 LSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRC 360
LSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRC
Sbjct: 301 LSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRC 360
Query: 361 LELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQR 420
LELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQR
Sbjct: 361 LELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQR 420
Query: 421 VMARHLHAILGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVV 480
VMARHLHAILGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVV
Sbjct: 421 VMARHLHAILGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVV 480
Query: 481 SDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYE 540
SDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYE
Sbjct: 481 SDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYE 540
Query: 541 MASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNF 600
MASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNF
Sbjct: 541 MASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNF 600
Query: 601 QTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQ 660
QTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQ
Sbjct: 601 QTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQ 660
Query: 661 QLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLAL 720
QLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLAL
Sbjct: 661 QLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLAL 720
Query: 721 IRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD 777
IRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD
Sbjct: 721 IRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD 777
>gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens]
Length = 756
Score = 1516 bits (3926), Expect = 0.0
Identities = 745/745 (100%), Positives = 745/745 (100%)
Query: 33 GLQDDEDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRTPESQLFSIED 92
GLQDDEDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRTPESQLFSIED
Sbjct: 12 GLQDDEDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRTPESQLFSIED 71
Query: 93 IQEVRMGHRTEGLEKFARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHH 152
IQEVRMGHRTEGLEKFARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHH
Sbjct: 72 IQEVRMGHRTEGLEKFARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHH 131
Query: 153 SGSMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHS 212
SGSMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHS
Sbjct: 132 SGSMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHS 191
Query: 213 QTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALA 272
QTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALA
Sbjct: 192 QTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALA 251
Query: 273 LSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSH 332
LSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSH
Sbjct: 252 LSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSH 311
Query: 333 NTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLR 392
NTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLR
Sbjct: 312 NTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLR 371
Query: 393 AIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSLPSPEQL 452
AIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSLPSPEQL
Sbjct: 372 AIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSLPSPEQL 431
Query: 453 KGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQE 512
KGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQE
Sbjct: 432 KGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQE 491
Query: 513 LSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIY 572
LSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIY
Sbjct: 492 LSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIY 551
Query: 573 PAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDP 632
PAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDP
Sbjct: 552 PAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDP 611
Query: 633 NGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQ 692
NGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQ
Sbjct: 612 NGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQ 671
Query: 693 TAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYR 752
TAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYR
Sbjct: 672 TAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYR 731
Query: 753 HVHLMSKNGDQHPSATLFVKISLQD 777
HVHLMSKNGDQHPSATLFVKISLQD
Sbjct: 732 HVHLMSKNGDQHPSATLFVKISLQD 756
>gi|19115964 phospholipase C delta 3 [Homo sapiens]
Length = 789
Score = 760 bits (1962), Expect = 0.0
Identities = 382/750 (50%), Positives = 515/750 (68%), Gaps = 17/750 (2%)
Query: 30 RRLGLQDDEDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRTPESQLFS 89
+++GL +DED++A+L+GS+L K++S +W +ER Y+LQED ++W + R++ R P +F
Sbjct: 52 KKMGLTEDEDVRAMLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQ-RRIPRAPSQHIFF 110
Query: 90 IEDIQEVRMGHRTEGLEKFARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKI 149
++ I+ VR GH++EGL +F RC +I FK +R LDL AP+ +AQ WV GL K+
Sbjct: 111 VQHIEAVREGHQSEGLRRFGGAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKL 170
Query: 150 IHHSGSMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFREC 209
+M QR++L HWIHS L +AD N+D+KMSFKE+++ L+ +N+ ++D YA +F+EC
Sbjct: 171 RARLDAMSQRERLDHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKEC 230
Query: 210 DHSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGP 269
DHS D LE EIE F + L +R E++ F + +G LS +L+ FL+ Q EE A
Sbjct: 231 DHSNNDRLEGAEIEEFLRRLLKRPELEEIFHQYSGEDRVLSAPELLEFLE-DQGEEGATL 289
Query: 270 ALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVS 329
A A LI+ YE +ETAK MT DGF+MYLLS +G+A H V+QDM QPL+HY +S
Sbjct: 290 ARAQQLIQTYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFIS 349
Query: 330 SSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCD 389
SSHNTYL + Q+ GPSSTEAY+RA +GCRC+ELDCW+GP EP+IYHG+T TSKILF D
Sbjct: 350 SSHNTYLTDSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRD 409
Query: 390 VLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVT-NSLPS 448
V++A+RD+AF SPYPVILSLENHC LEQQ MARHL ILG ML+ + LD LPS
Sbjct: 410 VVQAVRDHAFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEELPS 469
Query: 449 PEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLR 508
PEQLKG++L+KGKKL G + ++DE E E EA R K +
Sbjct: 470 PEQLKGRVLVKGKKLPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQRRLAK------Q 523
Query: 509 LAQELSDMVIYCKSVHFGGF-SSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGH 567
++ ELS + +YC + +P P +++S SE +A +L++E+GN FVRHN
Sbjct: 524 ISPELSALAVYCHATRLRTLHPAPNAPQPC--QVSSLSERKAKKLIREAGNSFVRHNARQ 581
Query: 568 LSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPA 627
L+R+YP G R +S+NYSP EMWN GCQ+VALNFQTPG EMD+ GRF NG CGYVLKPA
Sbjct: 582 LTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVLKPA 641
Query: 628 FLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNK-NSIVDPKVTVEIHGVSR 686
LR P+ TF+P + P R L+I+V++ QQLPK+N K +SIVDP V +EIHGV
Sbjct: 642 CLRQPDSTFDP----EYPGPPRTTLSIQVLTAQQLPKLNAEKPHSIVDPLVRIEIHGVPA 697
Query: 687 DVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNS 746
D A ++T + NNGFNP W F++ P+LAL+RF+VEDYDA+S NDF+GQ T+PL+S
Sbjct: 698 DCARQETDYVLNNGFNPRWGQTLQFQLRAPELALVRFVVEDYDATSPNDFVGQFTLPLSS 757
Query: 747 LKQGYRHVHLMSKNGDQHPSATLFVKISLQ 776
LKQGYRH+HL+SK+G ATLF++I +Q
Sbjct: 758 LKQGYRHIHLLSKDGASLSPATLFIQIRIQ 787
>gi|14249340 phospholipase C, delta 4 [Homo sapiens]
Length = 762
Score = 689 bits (1778), Expect = 0.0
Identities = 364/756 (48%), Positives = 496/756 (65%), Gaps = 21/756 (2%)
Query: 34 LQDDEDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTIWQESRKVMRTPESQLFSIEDI 93
L D+DL + +G + KV+S SW++ R+++LQ D T+W + R FSI D+
Sbjct: 9 LTTDQDLLLMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQA--RGSAKPSFSISDV 66
Query: 94 QEVRMGHRTEGLEKFARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHS 153
+ +R GH +E L A ++P ++ F+IVF +R+ LDL+A S +AQ W+ GL ++
Sbjct: 67 ETIRNGHDSELLRSLAEELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLV 126
Query: 154 GSMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQ 213
SMD +++L W+ ++ DKN+D KMSF+E+Q L +N+++D YA +F+ D SQ
Sbjct: 127 TSMDHQERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAADTSQ 186
Query: 214 TDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALAL 273
+ +LE EE FYK LT+R E+ F + G+ L++ + + FLQ +Q+E LAL
Sbjct: 187 SGTLEGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELAL 246
Query: 274 SLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHN 333
LI+RYEPS++ K + ++ DGFL YL S DG F+ A +YQDM QPL+HY + SSHN
Sbjct: 247 ELIDRYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSHN 306
Query: 334 TYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRA 393
TYL+ DQL G SS E YIRAL +GCRC+E+D WDGP+ EP++YHG+T TS+ILF DV+
Sbjct: 307 TYLVGDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVAT 366
Query: 394 IRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGV-TNSLPSPEQL 452
+ YAF+ S YPVILSLE HC+ EQQ+ MARHL ILG LL+ LDGV LPSPE+L
Sbjct: 367 VAQYAFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEEL 426
Query: 453 KGKILLKGKKL---GGLLPPGGEGGPEATVVSDEDEAA-----EMEDEAVRSRVQHKPKE 504
+ KIL+KGKKL L E PE +E E A E E E +Q+K K+
Sbjct: 427 RRKILVKGKKLTLEEDLEYEEEEAEPEL----EESELALESQFETEPEPQEQNLQNKDKK 482
Query: 505 DKLR--LAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVR 562
K + L LS +VIY KSV F F+ FYE++SFSE +A RL++E+GN FV+
Sbjct: 483 KKSKPILCPALSSLVIYLKSVSFRSFTH-SKEHYHFYEISSFSETKAKRLIKEAGNEFVQ 541
Query: 563 HNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGY 622
HN LSR+YP+G RTDSSNY+P E+WN GCQ+VA+N QT G EMD+ G F+ NG CGY
Sbjct: 542 HNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAMNMQTAGLEMDICDGHFRQNGGCGY 601
Query: 623 VLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNK-NSIVDPKVTVEI 681
VLKP FLRD +F+P P+ A+ L I+VISGQQLPKV+K K SIVDP V V+I
Sbjct: 602 VLKPDFLRDIQSSFHPEK-PISPFKAQTLL-IQVISGQQLPKVDKTKEGSIVDPLVKVQI 659
Query: 682 HGVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQST 741
GV D A ++T + NNGFNP+W F V+VP+LA++RF+V DYD S+NDFIGQ T
Sbjct: 660 FGVRLDTARQETNYVENNGFNPYWGQTLCFRVLVPELAMLRFVVMDYDWKSRNDFIGQYT 719
Query: 742 IPLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD 777
+P ++QGYRH+HL+SK+G A++FV I +Q+
Sbjct: 720 LPWTCMQQGYRHIHLLSKDGISLRPASIFVYICIQE 755
>gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens]
Length = 1127
Score = 484 bits (1247), Expect = e-136
Identities = 287/753 (38%), Positives = 431/753 (57%), Gaps = 29/753 (3%)
Query: 40 LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFSIEDIQEVRM 98
+ ++++GS+L KV+S+S R++ L D +++ W+ S+K E I+ I+EVR
Sbjct: 140 INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRT 196
Query: 99 GHRTEGLEK--FARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSG-S 155
G T+ + + ED FS+++ + +LDL+A S A WV GL +I + +
Sbjct: 197 GKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHT 256
Query: 156 MDQRQKLQH-----WIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFREC- 209
+D + Q W+ + D + ++ ++ LN + S F+E
Sbjct: 257 LDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELH 316
Query: 210 ---DHSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEA 266
D + T+ ++E IE F+++ T R EI + + + E L L+ FL+ +Q
Sbjct: 317 KSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH 375
Query: 267 AGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHY 326
++L +I +YEPS+ + + ++ DGF YL+S D F H++V QDM QPLSHY
Sbjct: 376 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHY 435
Query: 327 LVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKIL 386
++SSHNTYL+EDQ GPS YIRAL GCR +ELD WDGP+ EP+IY G+T TS+I+
Sbjct: 436 FINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIV 495
Query: 387 FCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSL 446
F V+ I YAF AS YP+IL LENHC+++QQ+VM +H+ +LG L + + L
Sbjct: 496 FRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEESYL 555
Query: 447 PSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQ--HKPKE 504
PSP+ LKGKIL+K KKL G EG V+DEDE AEM + ++ +
Sbjct: 556 PSPDVLKGKILIKAKKLSSNC-SGVEGD-----VTDEDEGAEMSQRMGKENMEQPNNVPV 609
Query: 505 DKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHN 564
+ +L +ELS++V CKSV F F Q ++E+ SF+E A + E+ FV +N
Sbjct: 610 KRFQLCKELSELVSICKSVQFKEF-QVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYN 668
Query: 565 VGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVL 624
L+R++P+ R DSSN +P + W GCQIVA+NFQTPG MD+ G F+ NG CGYVL
Sbjct: 669 KRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVL 728
Query: 625 KPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKN--KNSIVDPKVTVEIH 682
+PA +R+ F+ P + + L+I++ISGQ PK + K +VDP V VEIH
Sbjct: 729 RPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIH 788
Query: 683 GVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTI 742
G+ D A ++T + NG P +D F F++ +P+LA++RF+V D D ++FIGQ TI
Sbjct: 789 GIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQYTI 847
Query: 743 PLNSLKQGYRHVHLMSKNGDQHPSATLFVKISL 775
P L+ GYRHV L S G+ A+LFV +++
Sbjct: 848 PFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 880
>gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens]
Length = 1001
Score = 484 bits (1247), Expect = e-136
Identities = 287/753 (38%), Positives = 431/753 (57%), Gaps = 29/753 (3%)
Query: 40 LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFSIEDIQEVRM 98
+ ++++GS+L KV+S+S R++ L D +++ W+ S+K E I+ I+EVR
Sbjct: 14 INSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKK---DSEKAKIDIKSIKEVRT 70
Query: 99 GHRTEGLEK--FARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSG-S 155
G T+ + + ED FS+++ + +LDL+A S A WV GL +I + +
Sbjct: 71 GKNTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHT 130
Query: 156 MDQRQKLQH-----WIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFREC- 209
+D + Q W+ + D + ++ ++ LN + S F+E
Sbjct: 131 LDMLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELH 190
Query: 210 ---DHSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEA 266
D + T+ ++E IE F+++ T R EI + + + E L L+ FL+ +Q
Sbjct: 191 KSKDKAGTEVTKEEFIEVFHELCT-RPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAH 249
Query: 267 AGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHY 326
++L +I +YEPS+ + + ++ DGF YL+S D F H++V QDM QPLSHY
Sbjct: 250 INEEISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHY 309
Query: 327 LVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKIL 386
++SSHNTYL+EDQ GPS YIRAL GCR +ELD WDGP+ EP+IY G+T TS+I+
Sbjct: 310 FINSSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIV 369
Query: 387 FCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSL 446
F V+ I YAF AS YP+IL LENHC+++QQ+VM +H+ +LG L + + L
Sbjct: 370 FRSVIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEESYL 429
Query: 447 PSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQ--HKPKE 504
PSP+ LKGKIL+K KKL G EG V+DEDE AEM + ++ +
Sbjct: 430 PSPDVLKGKILIKAKKLSSNC-SGVEGD-----VTDEDEGAEMSQRMGKENMEQPNNVPV 483
Query: 505 DKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHN 564
+ +L +ELS++V CKSV F F Q ++E+ SF+E A + E+ FV +N
Sbjct: 484 KRFQLCKELSELVSICKSVQFKEF-QVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYN 542
Query: 565 VGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVL 624
L+R++P+ R DSSN +P + W GCQIVA+NFQTPG MD+ G F+ NG CGYVL
Sbjct: 543 KRFLARVFPSPMRIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVL 602
Query: 625 KPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKN--KNSIVDPKVTVEIH 682
+PA +R+ F+ P + + L+I++ISGQ PK + K +VDP V VEIH
Sbjct: 603 RPAIMREEVSFFSANTKDSVPGVSPQLLHIKIISGQNFPKPKGSGAKGDVVDPYVYVEIH 662
Query: 683 GVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTI 742
G+ D A ++T + NG P +D F F++ +P+LA++RF+V D D ++FIGQ TI
Sbjct: 663 GIPADCAEQRTKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIG-DEFIGQYTI 721
Query: 743 PLNSLKQGYRHVHLMSKNGDQHPSATLFVKISL 775
P L+ GYRHV L S G+ A+LFV +++
Sbjct: 722 PFECLQTGYRHVPLQSLTGEVLAHASLFVHVAI 754
>gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens]
Length = 1095
Score = 466 bits (1199), Expect = e-131
Identities = 291/745 (39%), Positives = 412/745 (55%), Gaps = 30/745 (4%)
Query: 46 GSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFSIEDIQEVRMGHRTEG 104
G +L KV+ +S RF+ L D + + W+ S+K + E I I+E+R+G TE
Sbjct: 118 GCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDL---EKAKLDISAIKEIRLGKNTET 174
Query: 105 LEK--FARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSGS----MDQ 158
A + ED FSI+ + +LDL+A S A WV GL ++ S M+
Sbjct: 175 FRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEG 234
Query: 159 RQKLQH--WIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQ--- 213
Q W+ + AD + + M +K+LN + ++ R F+E S+
Sbjct: 235 NQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSKEKL 294
Query: 214 -TDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALA 272
T E+E EAF ++ T R E+ + + + E L + L+ FL+ +Q +
Sbjct: 295 TTRVTEEEFCEAFCELCT-RPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITEDIC 353
Query: 273 LSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSH 332
L +I RYE SE + + + DGF YLLS++ F ++V QDM QPLSHY +++SH
Sbjct: 354 LDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASH 413
Query: 333 NTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLR 392
NTYL+EDQ GP+ YIRAL GCR +ELD DG + EPI+ + T+ + F V+
Sbjct: 414 NTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSVIE 473
Query: 393 AIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSLPSPEQL 452
I +AF AS YP+IL L NHC+L QQ+VMA+ + + G L + LPSPE+L
Sbjct: 474 VINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSESYLPSPEKL 533
Query: 453 KGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQE 512
K I++KGKKL P EG V+DEDE AEM + R V + ++ ++RL +E
Sbjct: 534 KRMIIVKGKKLPS-DPDVLEG-----EVTDEDEEAEM---SRRMSVDYNGEQKQIRLCRE 584
Query: 513 LSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIY 572
LSD+V CKSV + F Q ++EM SFSE A R+ E FV +N LSRIY
Sbjct: 585 LSDLVSICKSVQYRDFEL-SMKSQNYWEMCSFSETEASRIANEYPEDFVNYNKKFLSRIY 643
Query: 573 PAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDP 632
P+ R DSSN +P + WN GCQIVA+NFQTPGP MD++ G F NG CGYVL+P+ +RD
Sbjct: 644 PSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDE 703
Query: 633 NGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNK--NKNSIVDPKVTVEIHGVSRDVAS 690
F+ P + L+I++ISGQ PK K ++DP V +EIHG+ D +
Sbjct: 704 VSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIPADCSE 763
Query: 691 RQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQG 750
++T + N NP +D F F+V +P+LA+IRF+V D D ++FIGQ TIP L+ G
Sbjct: 764 QRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIG-DEFIGQYTIPFECLQPG 822
Query: 751 YRHVHLMSKNGDQHPSATLFVKISL 775
YRHV L S GD TLFV I++
Sbjct: 823 YRHVPLRSFVGDIMEHVTLFVHIAI 847
>gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens]
Length = 997
Score = 466 bits (1199), Expect = e-131
Identities = 291/745 (39%), Positives = 412/745 (55%), Gaps = 30/745 (4%)
Query: 46 GSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFSIEDIQEVRMGHRTEG 104
G +L KV+ +S RF+ L D + + W+ S+K + E I I+E+R+G TE
Sbjct: 20 GCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDL---EKAKLDISAIKEIRLGKNTET 76
Query: 105 LEK--FARDVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKIIHHSGS----MDQ 158
A + ED FSI+ + +LDL+A S A WV GL ++ S M+
Sbjct: 77 FRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLDFMEG 136
Query: 159 RQKLQH--WIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQ--- 213
Q W+ + AD + + M +K+LN + ++ R F+E S+
Sbjct: 137 NQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKSKEKL 196
Query: 214 -TDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALA 272
T E+E EAF ++ T R E+ + + + E L + L+ FL+ +Q +
Sbjct: 197 TTRVTEEEFCEAFCELCT-RPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITEDIC 255
Query: 273 LSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSH 332
L +I RYE SE + + + DGF YLLS++ F ++V QDM QPLSHY +++SH
Sbjct: 256 LDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYINASH 315
Query: 333 NTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLR 392
NTYL+EDQ GP+ YIRAL GCR +ELD DG + EPI+ + T+ + F V+
Sbjct: 316 NTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRSVIE 375
Query: 393 AIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDGVTNSLPSPEQL 452
I +AF AS YP+IL L NHC+L QQ+VMA+ + + G L + LPSPE+L
Sbjct: 376 VINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSESYLPSPEKL 435
Query: 453 KGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQE 512
K I++KGKKL P EG V+DEDE AEM + R V + ++ ++RL +E
Sbjct: 436 KRMIIVKGKKLPS-DPDVLEG-----EVTDEDEEAEM---SRRMSVDYNGEQKQIRLCRE 486
Query: 513 LSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIY 572
LSD+V CKSV + F Q ++EM SFSE A R+ E FV +N LSRIY
Sbjct: 487 LSDLVSICKSVQYRDFEL-SMKSQNYWEMCSFSETEASRIANEYPEDFVNYNKKFLSRIY 545
Query: 573 PAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDP 632
P+ R DSSN +P + WN GCQIVA+NFQTPGP MD++ G F NG CGYVL+P+ +RD
Sbjct: 546 PSAMRIDSSNLNPQDFWNCGCQIVAMNFQTPGPMMDLHTGWFLQNGGCGYVLRPSIMRDE 605
Query: 633 NGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNK--NKNSIVDPKVTVEIHGVSRDVAS 690
F+ P + L+I++ISGQ PK K ++DP V +EIHG+ D +
Sbjct: 606 VSYFSANTKGILPGVSPLALHIKIISGQNFPKPKGACAKGDVIDPYVCIEIHGIPADCSE 665
Query: 691 RQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQG 750
++T + N NP +D F F+V +P+LA+IRF+V D D ++FIGQ TIP L+ G
Sbjct: 666 QRTKTVQQNSDNPIFDETFEFQVNLPELAMIRFVVLDDDYIG-DEFIGQYTIPFECLQPG 724
Query: 751 YRHVHLMSKNGDQHPSATLFVKISL 775
YRHV L S GD TLFV I++
Sbjct: 725 YRHVPLRSFVGDIMEHVTLFVHIAI 749
>gi|25188201 phospholipase C, zeta 1 [Homo sapiens]
Length = 608
Score = 460 bits (1184), Expect = e-129
Identities = 254/600 (42%), Positives = 352/600 (58%), Gaps = 7/600 (1%)
Query: 174 DKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQTDSLEDEEIEAFYKMLTQRV 233
D + K++ ++ Q L++L+I+ + ++IF++ D + + EE A Y+++T R
Sbjct: 12 DDFRGGKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLKQGRITIEEFRAIYRIITHRE 71
Query: 234 EIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALALSLIERYEPSETAKAQRQMTK 293
EI F + + + L L FL +Q A+A +I++YEP E + QM+
Sbjct: 72 EIIEIFNTYSENRKILLASNLAQFLTQEQYAAEMSKAIAFEIIQKYEPIEEVRKAHQMSL 131
Query: 294 DGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRA 353
+GF Y+ S + F R+VYQDM PL+ Y +SSSHNTYL+ DQL GPS Y+ A
Sbjct: 132 EGFTRYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSA 191
Query: 354 LCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENH 413
L KGCRCLE+DCWDG EP++YHGYT TSK+LF V++AI YAF S YPV+LSLENH
Sbjct: 192 LVKGCRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENH 251
Query: 414 CTLEQQRVMARHLHAILGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKLGGLLPPGGEG 473
C+ QQ VMA +L A G LL+ LD ++LPSPE LK KIL+K KK+G L
Sbjct: 252 CSTAQQEVMADNLQATFGESLLSDMLDDFPDTLPSPEALKFKILVKNKKIGTLKETHERK 311
Query: 474 GPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVHFGGFSSPGT 533
G + + + E + V + K K KL++A LSD+VIY K+ F F
Sbjct: 312 GSDKRGDNQDKETGVKKLPGV--MLFKKKKTRKLKIALALSDLVIYTKAEKFKSFQH-SR 368
Query: 534 PGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGC 593
Q F E S E +A +L + + F+ H ++RIYP R DSSN++P E WN GC
Sbjct: 369 LYQQFNENNSIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQEFWNIGC 428
Query: 594 QIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLN 653
Q+VALNFQTPG MD+ G+F DNG GY+LKP FLR+ FNP + +G L
Sbjct: 429 QMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNPSNIKEG---MPITLT 485
Query: 654 IRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEFAFEV 713
IR+ISG QLP + + N D V +E+ GV D +QT VI N F+P W+ F F +
Sbjct: 486 IRLISGIQLPLTHSSSNK-GDSLVIIEVFGVPNDQMKQQTRVIKKNAFSPRWNETFTFII 544
Query: 714 VVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSATLFVKI 773
VP+LALIRF+VE + N+F+GQ T+PL + +GYR + L S+ G+ A+LFV +
Sbjct: 545 HVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRRIPLFSRMGESLEPASLFVYV 604
>gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens]
Length = 1194
Score = 360 bits (923), Expect = 4e-99
Identities = 246/732 (33%), Positives = 363/732 (49%), Gaps = 110/732 (15%)
Query: 131 LIAPSPADAQHWVLGLHKIIHHSGSMDQRQKL---QHW--------------IHSCLRKA 173
++A +P + WV GL IIH+ + + +HW + S R
Sbjct: 114 MVAENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTF 173
Query: 174 DKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQTDSLEDEEIEAFYKMLTQRV 233
K K+ F+ L KEL + + D + + E+ + + R
Sbjct: 174 ASGKTEKVIFQAL----KELGLPSGKN---------DEIEPTAFSYEKFYELTQKICPRT 220
Query: 234 EIDRTFAEAAGSG-ETLSVDQLVTFLQHQQREEAAGPAL--------ALSLIERYEPSET 284
+I+ F + G + L+VDQLV+FL QR+ L A+ +IE YEP E
Sbjct: 221 DIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDED 280
Query: 285 AKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNTYLLEDQLAGP 344
K + ++ DGF YL+S + + L +YQ+M PL+HY +SSSHNTYL Q G
Sbjct: 281 LKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGK 340
Query: 345 SSTEAYIRALCKGCRCLELDCWD--GPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKAS 402
SS E Y + L GCRC+ELDCWD G +QEPII HG + ILF DV++AI++ AF S
Sbjct: 341 SSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTS 400
Query: 403 PYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDG----VTNSLPSPEQLKGKILL 458
YPVILS ENHC+ QQ M+++ + G +LL + L+ +LPSP LK KIL+
Sbjct: 401 EYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILI 460
Query: 459 KGKKLG-----------GLLPPGGEGGPEATVVSDED----EAAEMEDEA---------- 493
K K+L + GE A ++ D++ E+A+ E+EA
Sbjct: 461 KNKRLKPEVEKKQLEALRSMMEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNEL 520
Query: 494 ------VRSRVQHKPKEDKLRLAQE-------------------LSDMVIYCKSVHFGGF 528
+ V + K+ + + E LS M+ Y + V F GF
Sbjct: 521 SADDLGHKEAVANSVKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGF 580
Query: 529 SSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEM 588
Y M+SF+E+ L L+ FV +N +SRIYP G R DSSNY P
Sbjct: 581 -HVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIF 639
Query: 589 WNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWA 648
WN GCQ+V+LN+QTP M + QG+F+ NG+CGY+LKP F+R P+ TF+P +
Sbjct: 640 WNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVI 699
Query: 649 RKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQ--TAVITNNGFNPWWD 706
+++VISGQ L + + V V+++G+ D ++ T ++ NNG NP ++
Sbjct: 700 AATCSVQVISGQFL------SDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYN 753
Query: 707 TE-FAF-EVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQH 764
E F F +V++PDLA++R V D N IGQ +PL+ L+ GYRH+ L ++
Sbjct: 754 EESFVFRKVILPDLAVLRIAVYD----DNNKLIGQRILPLDGLQAGYRHISLRNEGNKPL 809
Query: 765 PSATLFVKISLQ 776
T+F I L+
Sbjct: 810 SLPTIFCNIVLK 821
>gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens]
Length = 1175
Score = 360 bits (923), Expect = 4e-99
Identities = 246/732 (33%), Positives = 363/732 (49%), Gaps = 110/732 (15%)
Query: 131 LIAPSPADAQHWVLGLHKIIHHSGSMDQRQKL---QHW--------------IHSCLRKA 173
++A +P + WV GL IIH+ + + +HW + S R
Sbjct: 114 MVAENPEVTKQWVEGLRSIIHNFRANNVSPMTCLKKHWMKLAFMTNTNGKIPVRSITRTF 173
Query: 174 DKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQTDSLEDEEIEAFYKMLTQRV 233
K K+ F+ L KEL + + D + + E+ + + R
Sbjct: 174 ASGKTEKVIFQAL----KELGLPSGKN---------DEIEPTAFSYEKFYELTQKICPRT 220
Query: 234 EIDRTFAEAAGSG-ETLSVDQLVTFLQHQQREEAAGPAL--------ALSLIERYEPSET 284
+I+ F + G + L+VDQLV+FL QR+ L A+ +IE YEP E
Sbjct: 221 DIEDLFKKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDED 280
Query: 285 AKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNTYLLEDQLAGP 344
K + ++ DGF YL+S + + L +YQ+M PL+HY +SSSHNTYL Q G
Sbjct: 281 LKKKGLISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGK 340
Query: 345 SSTEAYIRALCKGCRCLELDCWD--GPNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKAS 402
SS E Y + L GCRC+ELDCWD G +QEPII HG + ILF DV++AI++ AF S
Sbjct: 341 SSVEMYRQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTS 400
Query: 403 PYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLDG----VTNSLPSPEQLKGKILL 458
YPVILS ENHC+ QQ M+++ + G +LL + L+ +LPSP LK KIL+
Sbjct: 401 EYPVILSFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILI 460
Query: 459 KGKKLG-----------GLLPPGGEGGPEATVVSDED----EAAEMEDEA---------- 493
K K+L + GE A ++ D++ E+A+ E+EA
Sbjct: 461 KNKRLKPEVEKKQLEALRSMMEAGESASPANILEDDNEEEIESADQEEEAHPEFKFGNEL 520
Query: 494 ------VRSRVQHKPKEDKLRLAQE-------------------LSDMVIYCKSVHFGGF 528
+ V + K+ + + E LS M+ Y + V F GF
Sbjct: 521 SADDLGHKEAVANSVKKGLVTVEDEQAWMASYKYVGATTNIHPYLSTMINYAQPVKFQGF 580
Query: 529 SSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEM 588
Y M+SF+E+ L L+ FV +N +SRIYP G R DSSNY P
Sbjct: 581 -HVAEERNIHYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIF 639
Query: 589 WNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWA 648
WN GCQ+V+LN+QTP M + QG+F+ NG+CGY+LKP F+R P+ TF+P +
Sbjct: 640 WNAGCQMVSLNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVI 699
Query: 649 RKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQ--TAVITNNGFNPWWD 706
+++VISGQ L + + V V+++G+ D ++ T ++ NNG NP ++
Sbjct: 700 AATCSVQVISGQFL------SDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYN 753
Query: 707 TE-FAF-EVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQH 764
E F F +V++PDLA++R V D N IGQ +PL+ L+ GYRH+ L ++
Sbjct: 754 EESFVFRKVILPDLAVLRIAVYD----DNNKLIGQRILPLDGLQAGYRHISLRNEGNKPL 809
Query: 765 PSATLFVKISLQ 776
T+F I L+
Sbjct: 810 SLPTIFCNIVLK 821
>gi|12083581 phosphoinositide-specific phospholipase C beta 1
isoform a [Homo sapiens]
Length = 1216
Score = 328 bits (840), Expect = 2e-89
Identities = 223/617 (36%), Positives = 316/617 (51%), Gaps = 67/617 (10%)
Query: 212 SQTDSLEDEEI-----EAFYKMLTQRVEIDRTFAE-AAGSGETLSVDQLVTFLQHQQRE- 264
S+ DS+ E+ F L R EID F+E A S L+VDQ++ F+ +QR+
Sbjct: 197 SRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDP 256
Query: 265 ---EAAGPALALS----LIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQ 317
E P L LIE+YEP+ + + Q++ DGF+ YL + S + +
Sbjct: 257 RLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNE 316
Query: 318 DMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDG--PNQEPII 375
DM QPLSHY ++SSHNTYL QLAG SS E Y + L GCRC+ELDCW G +EP+I
Sbjct: 317 DMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVI 376
Query: 376 YHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHC-TLEQQRVMARHLHAILGPML 434
HG+T T++I F +V+ AI + AFK SP+P++LS ENH + +QQ MA + I G L
Sbjct: 377 THGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDAL 436
Query: 435 LNRPLD------GVTNSLPSPEQLKGKILLKGKK------------------------LG 464
L PL+ GV LPSP L KIL+K KK
Sbjct: 437 LMEPLEKYPLESGV--PLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSS 494
Query: 465 GLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVH 524
+ P G EA SD+D+ +D+ +S + + +E+S++V Y + V
Sbjct: 495 SMFEPSSPGAGEADTESDDDDD---DDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVK 551
Query: 525 FGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYS 584
F F ++F EM+SF E + L L +S FV +N LSRIYP G R DSSNY
Sbjct: 552 FESFEISKKRNKSF-EMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYM 610
Query: 585 PVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQG 644
P WN GCQ+VALNFQT M + G ++ NG GY LKP F+R P+ F+P
Sbjct: 611 PQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIV 670
Query: 645 PWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASR--QTAVITNNGFN 702
L++++ISGQ L + V V V++ G+ D + +T N N
Sbjct: 671 DGIVANTLSVKIISGQFL------SDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVN 724
Query: 703 PWWDTE-FAF-EVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKN 760
P W+ E F +VV+P LA +R V Y+ K FIG +P+ +++ GY ++ L ++
Sbjct: 725 PVWEEEPIVFKKVVLPTLACLRIAV--YEEGGK--FIGHRILPVQAIRPGYHYICLRNER 780
Query: 761 GDQHPSATLFVKISLQD 777
+FV I ++D
Sbjct: 781 NQPLTLPAVFVYIEVKD 797
>gi|33356544 phosphoinositide-specific phospholipase C beta 1
isoform b [Homo sapiens]
Length = 1173
Score = 328 bits (840), Expect = 2e-89
Identities = 223/617 (36%), Positives = 316/617 (51%), Gaps = 67/617 (10%)
Query: 212 SQTDSLEDEEI-----EAFYKMLTQRVEIDRTFAE-AAGSGETLSVDQLVTFLQHQQRE- 264
S+ DS+ E+ F L R EID F+E A S L+VDQ++ F+ +QR+
Sbjct: 197 SRNDSIPQEDFTPEVYRVFLNNLCPRPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDP 256
Query: 265 ---EAAGPALALS----LIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQ 317
E P L LIE+YEP+ + + Q++ DGF+ YL + S + +
Sbjct: 257 RLNEILYPPLKQEQVQVLIEKYEPNNSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNE 316
Query: 318 DMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDG--PNQEPII 375
DM QPLSHY ++SSHNTYL QLAG SS E Y + L GCRC+ELDCW G +EP+I
Sbjct: 317 DMSQPLSHYFINSSHNTYLTAGQLAGNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVI 376
Query: 376 YHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHC-TLEQQRVMARHLHAILGPML 434
HG+T T++I F +V+ AI + AFK SP+P++LS ENH + +QQ MA + I G L
Sbjct: 377 THGFTMTTEISFKEVIEAIAECAFKTSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDAL 436
Query: 435 LNRPLD------GVTNSLPSPEQLKGKILLKGKK------------------------LG 464
L PL+ GV LPSP L KIL+K KK
Sbjct: 437 LMEPLEKYPLESGV--PLPSPMDLMYKILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSS 494
Query: 465 GLLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVH 524
+ P G EA SD+D+ +D+ +S + + +E+S++V Y + V
Sbjct: 495 SMFEPSSPGAGEADTESDDDDD---DDDCKKSSMDEGTAGSEAMATEEMSNLVNYIQPVK 551
Query: 525 FGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYS 584
F F ++F EM+SF E + L L +S FV +N LSRIYP G R DSSNY
Sbjct: 552 FESFEISKKRNKSF-EMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYM 610
Query: 585 PVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQG 644
P WN GCQ+VALNFQT M + G ++ NG GY LKP F+R P+ F+P
Sbjct: 611 PQLFWNAGCQMVALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIV 670
Query: 645 PWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASR--QTAVITNNGFN 702
L++++ISGQ L + V V V++ G+ D + +T N N
Sbjct: 671 DGIVANTLSVKIISGQFL------SDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVN 724
Query: 703 PWWDTE-FAF-EVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKN 760
P W+ E F +VV+P LA +R V Y+ K FIG +P+ +++ GY ++ L ++
Sbjct: 725 PVWEEEPIVFKKVVLPTLACLRIAV--YEEGGK--FIGHRILPVQAIRPGYHYICLRNER 780
Query: 761 GDQHPSATLFVKISLQD 777
+FV I ++D
Sbjct: 781 NQPLTLPAVFVYIEVKD 797
>gi|95147333 phospholipase C, beta 2 [Homo sapiens]
Length = 1185
Score = 322 bits (825), Expect = 8e-88
Identities = 219/610 (35%), Positives = 312/610 (51%), Gaps = 70/610 (11%)
Query: 223 EAFYKMLTQRVEIDRTFAEAAGSGET-LSVDQLVTFLQHQQREEA--------AGPALAL 273
++F L R EID F + ++ + L F+ +QR+ A P
Sbjct: 209 KSFLMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQ 268
Query: 274 SLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHN 333
LI++YEPS + Q++ +G + +L + S + ++ DM QPL+HY ++SSHN
Sbjct: 269 GLIDKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHN 328
Query: 334 TYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDG--PNQEPIIYHGYTFTSKILFCDVL 391
TYL Q +G SS E Y + L GCRC+ELDCW G P++EPII HG+T T+ I F + +
Sbjct: 329 TYLTAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAI 388
Query: 392 RAIRDYAFKASPYPVILSLENHC-TLEQQRVMARHLHAILGPMLLNRPLD------GVTN 444
AI + AFK SPYP+ILS ENH + QQ MA + I G MLL PL+ GV
Sbjct: 389 EAIAESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVP- 447
Query: 445 SLPSPEQLKGKILLKGKK----------------LGGLLPPGGEGGPEATVVSDEDEAAE 488
LPSPE L+GKIL+K KK G PP G E TV + E E E
Sbjct: 448 -LPSPEDLRGKILIKNKKNQFSGPTSSSKDTGGEAEGSSPPSAPAG-EGTVWAGE-EGTE 504
Query: 489 MEDEAVRSRVQHKP---KEDKLRLAQ--------------ELSDMVIYCKSVHFGGFSSP 531
+E+E V + + E++++ Q E+S +V Y + F F
Sbjct: 505 LEEEEVEEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFS 564
Query: 532 GTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNG 591
++ Y ++SF+E +A LL ++ FV +N +SRIYP G R DSSNY P WN
Sbjct: 565 AQKNRS-YVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNA 623
Query: 592 GCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKR 651
GCQ+VALNFQT M F+ NG GY+LK F+R P+ FNP ++ +
Sbjct: 624 GCQMVALNFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATT 683
Query: 652 LNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVI--TNNGFNPWWDTE- 708
L+I VISGQ L + + V V VE+ G+ D R + + N NP W E
Sbjct: 684 LSITVISGQFLSERS------VRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEP 737
Query: 709 FAFE-VVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSA 767
F FE +++P+LA +R V + N F+G IP+N+L GY H+ L S++
Sbjct: 738 FVFEKILMPELASLRVAVME----EGNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMP 793
Query: 768 TLFVKISLQD 777
LF+ + ++D
Sbjct: 794 ALFIFLEMKD 803
>gi|78499633 phospholipase C, eta 2 [Homo sapiens]
Length = 1416
Score = 303 bits (777), Expect = 3e-82
Identities = 185/470 (39%), Positives = 263/470 (55%), Gaps = 16/470 (3%)
Query: 31 RLGLQDDEDLQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFS 89
+LG + + A+ +G Q++K++ S RFY L E I W+ SRK E S
Sbjct: 37 QLGPLVERCMGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRK----NEKAKIS 92
Query: 90 IEDIQEVRMGHRTEGLEKFAR-DVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHK 148
I+ IQEV G ++E +++ + CFSI R +LDL++ S A+ WV GL
Sbjct: 93 IDSIQEVSEGRQSEVFQRYPDGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRY 152
Query: 149 I---IHHSGSMDQRQKLQ-HWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARK 204
+ I S+ +RQ+ + W+ +ADKN D +S E+ L +LN+ + ++
Sbjct: 153 LMAGISDEDSLARRQRTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQ 212
Query: 205 IFRECD-HSQTDSLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQR 263
+FRE D +L EE AFYKM++ R ++ + + L L FLQ +Q+
Sbjct: 213 MFREADTDDHQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQK 272
Query: 264 EEAAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPL 323
+IE++EP K++ + DGF Y S G F+ H V+QDM QPL
Sbjct: 273 MAGVTLESCQDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPL 332
Query: 324 SHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTS 383
SHY ++SSHNTYL+ DQL S + Y L GCRC+E+DCWDGP+ EPI++HGYT TS
Sbjct: 333 SHYFITSSHNTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTS 392
Query: 384 KILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPML-LNRPLDGV 442
KILF DV+ I YAF + YPVILS+ENHC++ QQ+ MA++L ILG L L+
Sbjct: 393 KILFKDVIETINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSED 452
Query: 443 TNSLPSPEQLKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDE 492
+LPSP+ LKGKIL+KGKKL + E G VSDED A E++D+
Sbjct: 453 ATTLPSPQMLKGKILVKGKKLPANISEDAEEGE----VSDEDSADEIDDD 498
Score = 211 bits (537), Expect = 2e-54
Identities = 120/306 (39%), Positives = 179/306 (58%), Gaps = 18/306 (5%)
Query: 476 EATVVSDEDEAAEMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVHFGGFSSPGTPG 535
+A V + DE + R + K ++L++ LSD+V Y KSV
Sbjct: 592 KAASVEEGDEGQDSPGGQSRGATRQKKT---MKLSRALSDLVKYTKSVATHDIEMEAASS 648
Query: 536 QAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQI 595
++++SFSE +A ++LQ+ ++R N LSRIYP+ +R DSSNY+P WN GCQ+
Sbjct: 649 ---WQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQPFWNAGCQM 705
Query: 596 VALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLNIR 655
VALN+Q+ G + + + +F NG CGYVLKP + G FNP + P +K+L +R
Sbjct: 706 VALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCM--CQGVFNPNSEDPLPGQLKKQLVLR 763
Query: 656 VISGQQLPKVNK----NKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEFAF 711
+ISGQQLPK ++ I+DP V VEI G+ D + QT V+ +NGFNP W+ F
Sbjct: 764 IISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTWEETLVF 823
Query: 712 EVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSATLFV 771
V +P++AL+RFLV D+D + DFIGQ T+ +S+ GYRHV+L + A++FV
Sbjct: 824 MVHMPEIALVRFLVWDHDPIGR-DFIGQRTLAFSSMMPGYRHVYL-----EGMEEASIFV 877
Query: 772 KISLQD 777
+++ D
Sbjct: 878 HVAVSD 883
>gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens]
Length = 1002
Score = 293 bits (750), Expect = 4e-79
Identities = 170/461 (36%), Positives = 260/461 (56%), Gaps = 16/461 (3%)
Query: 40 LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFSIEDIQEVRM 98
+ + G+Q++K+K + R + L E + W+ SRK E I+ I +V
Sbjct: 19 MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRK----SEKAKILIDSIYKVTE 74
Query: 99 GHRTEGLEKFAR-DVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKI---IHHSG 154
G ++E + A + CF+I + +LDLI +P +A+ W+ GL + I
Sbjct: 75 GRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDED 134
Query: 155 SMDQRQKLQ-HWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQ 213
S+ +RQ+ W+ +ADKN D ++ +E+ + +LN+ + R++F+E D +
Sbjct: 135 SLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDE 194
Query: 214 TD-SLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALA 272
+L EE FYKM++ R ++ + + L+V++L FL+ +Q+
Sbjct: 195 NQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYC 254
Query: 273 LSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSH 332
L +I+++E SE K + + +GF ++ S F+ H VYQDM QPL +Y ++SSH
Sbjct: 255 LDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSH 314
Query: 333 NTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLR 392
NTYL DQL S + Y R L +GCRC+E+DCWDGP+ EP+++HGYT TSKILF DV+
Sbjct: 315 NTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVE 374
Query: 393 AIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLD-GVTNSLPSPEQ 451
I +AF + +PVILS+ENHC+++QQR +A++L I G L +D G LPSP+
Sbjct: 375 TINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQS 434
Query: 452 LKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDE 492
LKGKIL+KGKKL L E G VSDED A E+EDE
Sbjct: 435 LKGKILVKGKKLPYHLGDDAEEGE----VSDEDSADEIEDE 471
Score = 210 bits (534), Expect = 5e-54
Identities = 117/275 (42%), Positives = 171/275 (62%), Gaps = 16/275 (5%)
Query: 507 LRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVG 566
++L +ELSD+V+Y SV GT G SFSE RA +++Q+ F+ +N
Sbjct: 595 MKLCRELSDLVVYTNSVAAQDIVDDGTTGNVL----SFSETRAHQVVQQKSEQFMIYNQK 650
Query: 567 HLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKP 626
L+RIYP+ +R DSSN++P+ WN GCQ+VALN+Q+ G M + + +F+ NG CGYVLKP
Sbjct: 651 QLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKP 710
Query: 627 AFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPK----VNKNKNSIVDPKVTVEIH 682
+ GTFNP + P +K+L ++VISGQQLPK + ++ I+DP V VEI
Sbjct: 711 QQM--CKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEII 768
Query: 683 GVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTI 742
G+ D QT V+ +NGFNP W+ F V +P++AL+RFLV D+D + DF+GQ T+
Sbjct: 769 GLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGR-DFVGQRTV 827
Query: 743 PLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD 777
+SL GYRHV+L + A++FV I++ +
Sbjct: 828 TFSSLVPGYRHVYL-----EGLTEASIFVHITINE 857
>gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens]
Length = 1693
Score = 293 bits (750), Expect = 4e-79
Identities = 170/461 (36%), Positives = 260/461 (56%), Gaps = 16/461 (3%)
Query: 40 LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFSIEDIQEVRM 98
+ + G+Q++K+K + R + L E + W+ SRK E I+ I +V
Sbjct: 19 MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRK----SEKAKILIDSIYKVTE 74
Query: 99 GHRTEGLEKFAR-DVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKI---IHHSG 154
G ++E + A + CF+I + +LDLI +P +A+ W+ GL + I
Sbjct: 75 GRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDED 134
Query: 155 SMDQRQKLQ-HWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQ 213
S+ +RQ+ W+ +ADKN D ++ +E+ + +LN+ + R++F+E D +
Sbjct: 135 SLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDE 194
Query: 214 TD-SLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALA 272
+L EE FYKM++ R ++ + + L+V++L FL+ +Q+
Sbjct: 195 NQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYC 254
Query: 273 LSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSH 332
L +I+++E SE K + + +GF ++ S F+ H VYQDM QPL +Y ++SSH
Sbjct: 255 LDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSH 314
Query: 333 NTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLR 392
NTYL DQL S + Y R L +GCRC+E+DCWDGP+ EP+++HGYT TSKILF DV+
Sbjct: 315 NTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVE 374
Query: 393 AIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLD-GVTNSLPSPEQ 451
I +AF + +PVILS+ENHC+++QQR +A++L I G L +D G LPSP+
Sbjct: 375 TINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQS 434
Query: 452 LKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDE 492
LKGKIL+KGKKL L E G VSDED A E+EDE
Sbjct: 435 LKGKILVKGKKLPYHLGDDAEEGE----VSDEDSADEIEDE 471
Score = 210 bits (534), Expect = 5e-54
Identities = 117/275 (42%), Positives = 171/275 (62%), Gaps = 16/275 (5%)
Query: 507 LRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVG 566
++L +ELSD+V+Y SV GT G SFSE RA +++Q+ F+ +N
Sbjct: 595 MKLCRELSDLVVYTNSVAAQDIVDDGTTGNVL----SFSETRAHQVVQQKSEQFMIYNQK 650
Query: 567 HLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKP 626
L+RIYP+ +R DSSN++P+ WN GCQ+VALN+Q+ G M + + +F+ NG CGYVLKP
Sbjct: 651 QLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKP 710
Query: 627 AFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPK----VNKNKNSIVDPKVTVEIH 682
+ GTFNP + P +K+L ++VISGQQLPK + ++ I+DP V VEI
Sbjct: 711 QQM--CKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEII 768
Query: 683 GVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTI 742
G+ D QT V+ +NGFNP W+ F V +P++AL+RFLV D+D + DF+GQ T+
Sbjct: 769 GLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGR-DFVGQRTV 827
Query: 743 PLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD 777
+SL GYRHV+L + A++FV I++ +
Sbjct: 828 TFSSLVPGYRHVYL-----EGLTEASIFVHITINE 857
>gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens]
Length = 1655
Score = 293 bits (750), Expect = 4e-79
Identities = 170/461 (36%), Positives = 260/461 (56%), Gaps = 16/461 (3%)
Query: 40 LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFSIEDIQEVRM 98
+ + G+Q++K+K + R + L E + W+ SRK E I+ I +V
Sbjct: 1 MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRK----SEKAKILIDSIYKVTE 56
Query: 99 GHRTEGLEKFAR-DVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKI---IHHSG 154
G ++E + A + CF+I + +LDLI +P +A+ W+ GL + I
Sbjct: 57 GRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDED 116
Query: 155 SMDQRQKLQ-HWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQ 213
S+ +RQ+ W+ +ADKN D ++ +E+ + +LN+ + R++F+E D +
Sbjct: 117 SLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDE 176
Query: 214 TD-SLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALA 272
+L EE FYKM++ R ++ + + L+V++L FL+ +Q+
Sbjct: 177 NQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYC 236
Query: 273 LSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSH 332
L +I+++E SE K + + +GF ++ S F+ H VYQDM QPL +Y ++SSH
Sbjct: 237 LDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSH 296
Query: 333 NTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLR 392
NTYL DQL S + Y R L +GCRC+E+DCWDGP+ EP+++HGYT TSKILF DV+
Sbjct: 297 NTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVE 356
Query: 393 AIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLD-GVTNSLPSPEQ 451
I +AF + +PVILS+ENHC+++QQR +A++L I G L +D G LPSP+
Sbjct: 357 TINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQS 416
Query: 452 LKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDE 492
LKGKIL+KGKKL L E G VSDED A E+EDE
Sbjct: 417 LKGKILVKGKKLPYHLGDDAEEGE----VSDEDSADEIEDE 453
Score = 210 bits (534), Expect = 5e-54
Identities = 117/275 (42%), Positives = 171/275 (62%), Gaps = 16/275 (5%)
Query: 507 LRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVG 566
++L +ELSD+V+Y SV GT G SFSE RA +++Q+ F+ +N
Sbjct: 577 MKLCRELSDLVVYTNSVAAQDIVDDGTTGNVL----SFSETRAHQVVQQKSEQFMIYNQK 632
Query: 567 HLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKP 626
L+RIYP+ +R DSSN++P+ WN GCQ+VALN+Q+ G M + + +F+ NG CGYVLKP
Sbjct: 633 QLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKP 692
Query: 627 AFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPK----VNKNKNSIVDPKVTVEIH 682
+ GTFNP + P +K+L ++VISGQQLPK + ++ I+DP V VEI
Sbjct: 693 QQM--CKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEII 750
Query: 683 GVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTI 742
G+ D QT V+ +NGFNP W+ F V +P++AL+RFLV D+D + DF+GQ T+
Sbjct: 751 GLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGR-DFVGQRTV 809
Query: 743 PLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD 777
+SL GYRHV+L + A++FV I++ +
Sbjct: 810 TFSSLVPGYRHVYL-----EGLTEASIFVHITINE 839
>gi|11386139 phospholipase C beta 3 [Homo sapiens]
Length = 1234
Score = 291 bits (744), Expect = 2e-78
Identities = 222/680 (32%), Positives = 323/680 (47%), Gaps = 104/680 (15%)
Query: 172 KADKNKDNKMSFKELQNFLKELNIQVD---DSYARKIFRECDHSQTDSLEDEEIEAFYKM 228
K N+D ++ K + +V+ +S K F + + D E E F
Sbjct: 161 KLQVNQDGRIPVKNILKMFSADKKRVETALESCGLK-FNRSESIRPDEFSLEIFERFLNK 219
Query: 229 LTQRVEIDRTFAEAAGSGET-LSVDQLVTFLQHQQREEAAG--------PALALSLIERY 279
L R +ID+ E G+ L+++QL+ F+ +QR+ P+ A LIE+Y
Sbjct: 220 LCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLRPSQARLLIEKY 279
Query: 280 EPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSHNTYLLED 339
EP++ + QM+ +GF YL + L + DM QPLS Y ++SSHNTYL
Sbjct: 280 EPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFINSSHNTYLTAG 339
Query: 340 QLAGPSSTEAYIRALCKGCRCLELDCWDG--PNQEPIIYHGYTFTSKILFCDVLRAIRDY 397
QLAG SS E Y +AL GCRC+ELD W G P +EP I HG+T T+++ DVL AI +
Sbjct: 340 QLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVPLRDVLEAIAET 399
Query: 398 AFKASPYPVILSLENHC-TLEQQRVMARHLHA---------------------------I 429
AFK SPYPVILS ENH + +QQ MA + + +
Sbjct: 400 AFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLAPGVPLPSPQDL 459
Query: 430 LGPMLLN------------------RPLDGVTNSL--------PSPEQLKGKI------L 457
+G +L+ RPL+ ++L PS QL L
Sbjct: 460 MGRILVKNKKRHRPSAGGPDSAGRKRPLEQSNSALSESSAATEPSSPQLGSPSSDSCPGL 519
Query: 458 LKGKKLGGLLPP-------GGEG--------GPEATVVSDEDEAAEMEDEAVRSRVQHKP 502
G+++G P G EG GP +EDE E + + +
Sbjct: 520 SNGEEVGLEKPSLEPQKSLGDEGLNRGPYVLGPADREDEEEDEEEEEQTDPKKPTTDEGT 579
Query: 503 KEDKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVR 562
++ +E+S +V Y + V F F + + F EM+SF E +A+ L +S FV
Sbjct: 580 ASSEVNATEEMSTLVNYIEPVKFKSFEAARKRNKCF-EMSSFVETKAMEQLTKSPMEFVE 638
Query: 563 HNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGY 622
+N LSRIYP G R DSSNY P WN GCQ+VALNFQT M + G F+ NG GY
Sbjct: 639 YNKQQLSRIYPKGTRVDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGY 698
Query: 623 VLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIH 682
+LKP F+R P+ +F+P L ++VISGQ L + V V V++
Sbjct: 699 LLKPEFMRRPDKSFDPFTEVIVDGIVANALRVKVISGQFL------SDRKVGIYVEVDMF 752
Query: 683 GVSRDVASR-QTAVITNNGFNPWWDTE-FAF-EVVVPDLALIRFLVEDYDASSKNDFIGQ 739
G+ D + +T N FNP WD E F F +VV+P LA +R + ++ K F+G
Sbjct: 753 GLPVDTRRKYRTRTSQGNSFNPVWDEEPFDFPKVVLPTLASLR--IAAFEEGGK--FVGH 808
Query: 740 STIPLNSLKQGYRHVHLMSK 759
+P+++++ GY +V L ++
Sbjct: 809 RILPVSAIRSGYHYVCLRNE 828
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 241 bits (614), Expect = 2e-63
Identities = 150/395 (37%), Positives = 221/395 (55%), Gaps = 22/395 (5%)
Query: 90 IEDIQEVRMGHRTEGLEKF-ARDVPEDRCFSIVFKDQ--RNTLDLIAPSPADAQHWVLGL 146
I +I+E+R G ++ E+ A ED CF+I++ Q +TL L A S DA +W+ GL
Sbjct: 67 IMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAADSKEDAVNWLSGL 126
Query: 147 HKIIHHSG-SMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDS-YARK 204
KI+H + ++ W+ + D+ + N +S +EL+ L +N +V + + +
Sbjct: 127 -KILHQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTILPLINFKVSSAKFLKD 185
Query: 205 IFRECDHSQTDSLEDEEIEAFYK--MLTQRVEIDRTFAEAAG----------SGETLSVD 252
F E + D L E+ FYK M Q+ I F + + + +
Sbjct: 186 KFVEIG-AHKDELSFEQFHLFYKKLMFEQQKSILDEFKKDSSVFILGNTDRPDASAVYLH 244
Query: 253 QLVTFLQHQQREEAAGPALALS--LIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSL 310
FL H+Q+E A + + + + + A+ + D FL YL S + S +
Sbjct: 245 DFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPFLFVDEFLTYLFSRENSIWDE 304
Query: 311 AHRRV-YQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGP 369
+ V QDM PLSHY +SSSHNTYL DQL SS EAYIR L GCRC+ELDCWDGP
Sbjct: 305 KYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLRSESSPEAYIRCLRMGCRCIELDCWDGP 364
Query: 370 NQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAI 429
+ +P+IYHG+T T+KI F DV++AI+D+AF S +PVILS+E HC++EQQR MA+ +
Sbjct: 365 DGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTSSFPVILSIEEHCSVEQQRHMAKAFKEV 424
Query: 430 LGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKLG 464
G +LL +P + + LPSP QL+ KI++K KKLG
Sbjct: 425 FGDLLLTKPTEASADQLPSPSQLREKIIIKHKKLG 459
Score = 147 bits (372), Expect = 3e-35
Identities = 101/321 (31%), Positives = 159/321 (49%), Gaps = 28/321 (8%)
Query: 466 LLPPGGEGGPEATVVSDEDEAAEMEDEAVRSRV-QHKPKEDKLR-------LAQELSDMV 517
+L P +G P +D E +++R + KE+ ++ +A ELSD+V
Sbjct: 875 ILEPKQQGDPPVEFATDRVEELFEWFQSIREITWKIDTKENNMKYWEKNQSIAIELSDLV 934
Query: 518 IYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVGHLSRIYPAGWR 577
+YCK + F E+ SF E +A ++++ +++N L+R+YP G R
Sbjct: 935 VYCKPT---SKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKGLTRVYPKGQR 991
Query: 578 TDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKPAFLR----DPN 633
DSSNY P +W G Q+VALNFQT M + F NG GYVL+P +R DP
Sbjct: 992 VDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPESMRTEKYDPM 1051
Query: 634 GTFNPRALAQGPWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQT 693
+ R + L ++V+ + LPK+ + SI P V VEI G D +T
Sbjct: 1052 PPESQRKILM-------TLTVKVLGARHLPKLGR---SIACPFVEVEICGAEYDNNKFKT 1101
Query: 694 AVITNNGFNPWW---DTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQG 750
V+ +NG +P W + FE+ P+LA +RF+V + D S +F+ +T P+ ++K G
Sbjct: 1102 TVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLAHATYPIKAVKSG 1161
Query: 751 YRHVHLMSKNGDQHPSATLFV 771
+R V L + + A+L V
Sbjct: 1162 FRSVPLKNGYSEDIELASLLV 1182
>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
Length = 1291
Score = 224 bits (571), Expect = 2e-58
Identities = 137/395 (34%), Positives = 220/395 (55%), Gaps = 24/395 (6%)
Query: 90 IEDIQEVRMGHRTEGLEKFARDVP----EDRCFSIVF--KDQRNTLDLIAPSPADAQHWV 143
I +I+E+R G + +++ D + CF I++ + + TL L A S + W+
Sbjct: 75 IREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWI 134
Query: 144 LGLHKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDS-YA 202
GL ++ + +++ W+ D+N+++++S K+L+N L ++N +V + +
Sbjct: 135 KGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFL 194
Query: 203 RKIFRECDHSQTDSLEDEEIEAFYKML-TQRVEIDRTFAEAAG--SGET-----LSVDQL 254
R+ + + D + + + ++ + + +D F EA+ +GE +S+ +
Sbjct: 195 RERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEF 254
Query: 255 VTFLQHQQREEAAGPALALSLIERYEPSETAKAQRQMTK-----DGFLMYLLSADGSAFS 309
FL Q E A L ++ + S R++ + D F+ +L S + S ++
Sbjct: 255 QQFLLDYQGELWAVDRLQ---VQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWN 311
Query: 310 LAHRRVYQD-MGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDG 368
V D M PLSHY +SSSHNTYL DQ + SS EAY R L GCRC+ELDCWDG
Sbjct: 312 SQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDG 371
Query: 369 PNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHA 428
P+ P+IYHG+T T+KI F DVL I+++AF AS YPVILS+E+HC++ QQR MA++
Sbjct: 372 PDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKK 431
Query: 429 ILGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKL 463
+LG LL +P++ + LPSP QLK KIL+K KKL
Sbjct: 432 VLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKL 466
Score = 176 bits (446), Expect = 7e-44
Identities = 105/290 (36%), Positives = 159/290 (54%), Gaps = 8/290 (2%)
Query: 488 EMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSEN 547
E+ A + K E + ++A ELS++V+YC+ V F GT + +M+SF E
Sbjct: 928 EVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDE-EKIGTERACYRDMSSFPET 986
Query: 548 RALRLLQES-GNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPE 606
+A + + ++ G F+++N LSRIYP G R DSSNY P+ MW G Q+VALNFQTP
Sbjct: 987 KAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKP 1046
Query: 607 MDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVN 666
M + Q F CGYVL+P+ +RD F+P + ++I V+ + LP
Sbjct: 1047 MQMNQALFMTGRHCGYVLQPSTMRDE--AFDPFDKSSLRGLEPCAISIEVLGARHLP--- 1101
Query: 667 KNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTE-FAFEVVVPDLALIRFLV 725
KN IV P V +E+ G D ++T + +NG NP W + F F++ P+ A +RF+V
Sbjct: 1102 KNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVV 1161
Query: 726 EDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSATLFVKISL 775
+ D S +F+ Q+T P+ LK GYR V L + + A+L +KI +
Sbjct: 1162 YEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDI 1211
>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
Length = 1290
Score = 224 bits (571), Expect = 2e-58
Identities = 137/395 (34%), Positives = 220/395 (55%), Gaps = 24/395 (6%)
Query: 90 IEDIQEVRMGHRTEGLEKFARDVP----EDRCFSIVF--KDQRNTLDLIAPSPADAQHWV 143
I +I+E+R G + +++ D + CF I++ + + TL L A S + W+
Sbjct: 75 IREIKEIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWI 134
Query: 144 LGLHKIIHHSGSMDQRQKLQHWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDS-YA 202
GL ++ + +++ W+ D+N+++++S K+L+N L ++N +V + +
Sbjct: 135 KGLTWLMEDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFL 194
Query: 203 RKIFRECDHSQTDSLEDEEIEAFYKML-TQRVEIDRTFAEAAG--SGET-----LSVDQL 254
R+ + + D + + + ++ + + +D F EA+ +GE +S+ +
Sbjct: 195 RERLTDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLPEF 254
Query: 255 VTFLQHQQREEAAGPALALSLIERYEPSETAKAQRQMTK-----DGFLMYLLSADGSAFS 309
FL Q E A L ++ + S R++ + D F+ +L S + S ++
Sbjct: 255 QQFLLDYQGELWAVDRLQ---VQEFMLSFLRDPLREIEEPYFFLDEFVTFLFSKENSVWN 311
Query: 310 LAHRRVYQD-MGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDG 368
V D M PLSHY +SSSHNTYL DQ + SS EAY R L GCRC+ELDCWDG
Sbjct: 312 SQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIELDCWDG 371
Query: 369 PNQEPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHA 428
P+ P+IYHG+T T+KI F DVL I+++AF AS YPVILS+E+HC++ QQR MA++
Sbjct: 372 PDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNMAQYFKK 431
Query: 429 ILGPMLLNRPLDGVTNSLPSPEQLKGKILLKGKKL 463
+LG LL +P++ + LPSP QLK KIL+K KKL
Sbjct: 432 VLGDTLLTKPVEISADGLPSPNQLKRKILIKHKKL 466
Score = 176 bits (446), Expect = 7e-44
Identities = 105/290 (36%), Positives = 159/290 (54%), Gaps = 8/290 (2%)
Query: 488 EMEDEAVRSRVQHKPKEDKLRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSEN 547
E+ A + K E + ++A ELS++V+YC+ V F GT + +M+SF E
Sbjct: 928 EVAQTADARLTEGKIMERRKKIALELSELVVYCRPVPFDE-EKIGTERACYRDMSSFPET 986
Query: 548 RALRLLQES-GNGFVRHNVGHLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPE 606
+A + + ++ G F+++N LSRIYP G R DSSNY P+ MW G Q+VALNFQTP
Sbjct: 987 KAEKYVNKAKGKKFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKP 1046
Query: 607 MDVYQGRFQDNGACGYVLKPAFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPKVN 666
M + Q F CGYVL+P+ +RD F+P + ++I V+ + LP
Sbjct: 1047 MQMNQALFMTGRHCGYVLQPSTMRDE--AFDPFDKSSLRGLEPCAISIEVLGARHLP--- 1101
Query: 667 KNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTE-FAFEVVVPDLALIRFLV 725
KN IV P V +E+ G D ++T + +NG NP W + F F++ P+ A +RF+V
Sbjct: 1102 KNGRGIVCPFVEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVV 1161
Query: 726 EDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQHPSATLFVKISL 775
+ D S +F+ Q+T P+ LK GYR V L + + A+L +KI +
Sbjct: 1162 YEEDMFSDQNFLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDI 1211
>gi|117168250 phospholipase C, epsilon 1 [Homo sapiens]
Length = 2302
Score = 219 bits (557), Expect = 1e-56
Identities = 195/668 (29%), Positives = 288/668 (43%), Gaps = 161/668 (24%)
Query: 253 QLVTFLQHQQREEAAGPALALSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAH 312
QL FL + Q E + LS+I+++EPS + Q M+ +GF +L+ + A
Sbjct: 1328 QLNDFLVNCQGEHCTYDEI-LSIIQKFEPSISMCHQGLMSFEGFARFLMDKENFASKNDE 1386
Query: 313 RRV-YQDMGQPLSHYLVSSSHNTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQ 371
+ +++ PLS+Y + SSHNTYL QL G SS E Y + L +GCR +ELDCWDG +
Sbjct: 1387 SQENIKELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDGDDG 1446
Query: 372 EPIIYHGYTFTSKILFCDVLRAIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILG 431
PIIYHG+T T+KI F +V+ AI AF S P+I+S+ENHC+L QQR MA + G
Sbjct: 1447 MPIIYHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEIFKTVFG 1506
Query: 432 PMLLNRPLDGVTNS----LPSPEQLKGKILLKGKKLGGLLPP------------------ 469
L+ + L S LPSP+QL+ K+LLK KKL P
Sbjct: 1507 EKLVTKFLFETDFSDDPMLPSPDQLRKKVLLKNKKLKAHQTPVDILKQKAHQLASMQVQA 1566
Query: 470 --GGEGGPE-ATVVSDEDEAAE--------MEDEAVRSRVQHKPKEDKL----------- 507
GG P A +EDE E +D + R ++K DKL
Sbjct: 1567 YNGGNANPRPANNEEEEDEEDEYDYDYESLSDDNILEDRPENKSCNDKLQFEYNEEIPKR 1626
Query: 508 ---------------------------------RLAQELSDMVIYCKSVHFGGFS----- 529
++A ELSD+VIYC++V F G S
Sbjct: 1627 IKKADNSACNKGKVYDMELGEEFYLDQNKKESRQIAPELSDLVIYCQAVKFPGLSTLNAS 1686
Query: 530 -----------------SPG--TPGQ--AFYEMASFSENRALRLLQESGNGFVRHNVG-- 566
+PG +PG+ +F + + S +R E + +
Sbjct: 1687 GSSRGKERKSRKSIFGNNPGRMSPGETASFNKTSGKSSCEGIRQTWEESSSPLNPTTSLS 1746
Query: 567 ---------HLSRIYPAGWRTDSSNYSPVEMWNGGCQIV-------ALNFQTPGPEMDVY 610
H+S + + YS + CQ++ ++ P P M
Sbjct: 1747 AIIRTPKCYHISSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRIDSSNPNPLMFWL 1806
Query: 611 QG--------------------RFQDNGACGYVLKPAFLRDPN----GTFNP--RAL-AQ 643
G F+ NG CGYVLKP L D N F+P R L +
Sbjct: 1807 HGIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQKFSPLERDLDSM 1866
Query: 644 GPWWARKRLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNP 703
P ++ ++SGQ + NS+ P + V++ G+ D +T I N NP
Sbjct: 1867 DP----AVYSLTIVSGQNVCP----SNSMGSPCIEVDVLGMPLDSCHFRTKPIHRNTLNP 1918
Query: 704 WWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSLKQGYRHVHLMSKNGDQ 763
W+ +F F V DL +RF V + ++S+ Q IPL +LK+GYRH+ L + + +
Sbjct: 1919 MWNEQFLFHVHFEDLVFLRFAVVENNSSA---VTAQRIIPLKALKRGYRHLQLRNLHNEV 1975
Query: 764 HPSATLFV 771
++LF+
Sbjct: 1976 LEISSLFI 1983
>gi|209447073 synaptotagmin I [Homo sapiens]
Length = 422
Score = 44.7 bits (104), Expect = 3e-04
Identities = 28/105 (26%), Positives = 52/105 (49%), Gaps = 5/105 (4%)
Query: 651 RLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEFA 710
+L + ++ + L K++ + DP V + + + + ++T I N NP+++ F+
Sbjct: 289 KLTVVILEAKNLKKMDVG--GLSDPYVKIHLMQNGKRLKKKKTT-IKKNTLNPYYNESFS 345
Query: 711 FEVVVPDLALIRFLVE--DYDASSKNDFIGQSTIPLNSLKQGYRH 753
FEV + ++ +V DYD KND IG+ + NS RH
Sbjct: 346 FEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRH 390
Score = 38.1 bits (87), Expect = 0.031
Identities = 27/103 (26%), Positives = 50/103 (48%), Gaps = 7/103 (6%)
Query: 651 RLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEFA 710
+L + +I +LP ++ S DP V V + D + + NP ++ +F
Sbjct: 158 QLLVGIIQAAELPALDMGGTS--DPYVKVFL---LPDKKKKFETKVHRKTLNPVFNEQFT 212
Query: 711 FEVVVPDLA--LIRFLVEDYDASSKNDFIGQSTIPLNSLKQGY 751
F+V +L + V D+D SK+D IG+ +P+N++ G+
Sbjct: 213 FKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGH 255
>gi|5032139 synaptotagmin I [Homo sapiens]
Length = 422
Score = 44.7 bits (104), Expect = 3e-04
Identities = 28/105 (26%), Positives = 52/105 (49%), Gaps = 5/105 (4%)
Query: 651 RLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEFA 710
+L + ++ + L K++ + DP V + + + + ++T I N NP+++ F+
Sbjct: 289 KLTVVILEAKNLKKMDVG--GLSDPYVKIHLMQNGKRLKKKKTT-IKKNTLNPYYNESFS 345
Query: 711 FEVVVPDLALIRFLVE--DYDASSKNDFIGQSTIPLNSLKQGYRH 753
FEV + ++ +V DYD KND IG+ + NS RH
Sbjct: 346 FEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRH 390
Score = 38.1 bits (87), Expect = 0.031
Identities = 27/103 (26%), Positives = 50/103 (48%), Gaps = 7/103 (6%)
Query: 651 RLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEFA 710
+L + +I +LP ++ S DP V V + D + + NP ++ +F
Sbjct: 158 QLLVGIIQAAELPALDMGGTS--DPYVKVFL---LPDKKKKFETKVHRKTLNPVFNEQFT 212
Query: 711 FEVVVPDLA--LIRFLVEDYDASSKNDFIGQSTIPLNSLKQGY 751
F+V +L + V D+D SK+D IG+ +P+N++ G+
Sbjct: 213 FKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGH 255
>gi|209447070 synaptotagmin I [Homo sapiens]
Length = 422
Score = 44.7 bits (104), Expect = 3e-04
Identities = 28/105 (26%), Positives = 52/105 (49%), Gaps = 5/105 (4%)
Query: 651 RLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEFA 710
+L + ++ + L K++ + DP V + + + + ++T I N NP+++ F+
Sbjct: 289 KLTVVILEAKNLKKMDVG--GLSDPYVKIHLMQNGKRLKKKKTT-IKKNTLNPYYNESFS 345
Query: 711 FEVVVPDLALIRFLVE--DYDASSKNDFIGQSTIPLNSLKQGYRH 753
FEV + ++ +V DYD KND IG+ + NS RH
Sbjct: 346 FEVPFEQIQKVQVVVTVLDYDKIGKNDAIGKVFVGYNSTGAELRH 390
Score = 38.1 bits (87), Expect = 0.031
Identities = 27/103 (26%), Positives = 50/103 (48%), Gaps = 7/103 (6%)
Query: 651 RLNIRVISGQQLPKVNKNKNSIVDPKVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEFA 710
+L + +I +LP ++ S DP V V + D + + NP ++ +F
Sbjct: 158 QLLVGIIQAAELPALDMGGTS--DPYVKVFL---LPDKKKKFETKVHRKTLNPVFNEQFT 212
Query: 711 FEVVVPDLA--LIRFLVEDYDASSKNDFIGQSTIPLNSLKQGY 751
F+V +L + V D+D SK+D IG+ +P+N++ G+
Sbjct: 213 FKVPYSELGGKTLVMAVYDFDRFSKHDIIGEFKVPMNTVDFGH 255
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 43.9 bits (102), Expect = 6e-04
Identities = 33/98 (33%), Positives = 54/98 (55%), Gaps = 6/98 (6%)
Query: 652 LNIRVISGQQLPKVNKNKNSIVDP--KVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEF 709
L ++V+SG L K K+ DP K+++ + +R++A QT I NP W+ EF
Sbjct: 22 LRVKVVSGIDLAK--KDIFGASDPYVKLSLYVADENRELALVQTKTIKKT-LNPKWNEEF 78
Query: 710 AFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSL 747
F V + L+ F V D + +++DF+GQ +PL+ L
Sbjct: 79 YFRVNPSNHRLL-FEVFDENRLTRDDFLGQVDVPLSHL 115
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 43.9 bits (102), Expect = 6e-04
Identities = 33/98 (33%), Positives = 54/98 (55%), Gaps = 6/98 (6%)
Query: 652 LNIRVISGQQLPKVNKNKNSIVDP--KVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEF 709
L ++V+SG L K K+ DP K+++ + +R++A QT I NP W+ EF
Sbjct: 14 LRVKVVSGIDLAK--KDIFGASDPYVKLSLYVADENRELALVQTKTIKKT-LNPKWNEEF 70
Query: 710 AFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSL 747
F V + L+ F V D + +++DF+GQ +PL+ L
Sbjct: 71 YFRVNPSNHRLL-FEVFDENRLTRDDFLGQVDVPLSHL 107
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 43.9 bits (102), Expect = 6e-04
Identities = 33/98 (33%), Positives = 54/98 (55%), Gaps = 6/98 (6%)
Query: 652 LNIRVISGQQLPKVNKNKNSIVDP--KVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEF 709
L ++V+SG L K K+ DP K+++ + +R++A QT I NP W+ EF
Sbjct: 14 LRVKVVSGIDLAK--KDIFGASDPYVKLSLYVADENRELALVQTKTIKKT-LNPKWNEEF 70
Query: 710 AFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSL 747
F V + L+ F V D + +++DF+GQ +PL+ L
Sbjct: 71 YFRVNPSNHRLL-FEVFDENRLTRDDFLGQVDVPLSHL 107
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 43.9 bits (102), Expect = 6e-04
Identities = 33/98 (33%), Positives = 54/98 (55%), Gaps = 6/98 (6%)
Query: 652 LNIRVISGQQLPKVNKNKNSIVDP--KVTVEIHGVSRDVASRQTAVITNNGFNPWWDTEF 709
L ++V+SG L K K+ DP K+++ + +R++A QT I NP W+ EF
Sbjct: 22 LRVKVVSGIDLAK--KDIFGASDPYVKLSLYVADENRELALVQTKTIKKT-LNPKWNEEF 78
Query: 710 AFEVVVPDLALIRFLVEDYDASSKNDFIGQSTIPLNSL 747
F V + L+ F V D + +++DF+GQ +PL+ L
Sbjct: 79 YFRVNPSNHRLL-FEVFDENRLTRDDFLGQVDVPLSHL 115
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.403
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 30,661,402
Number of Sequences: 37866
Number of extensions: 1443207
Number of successful extensions: 4569
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 36
Number of HSP's successfully gapped in prelim test: 86
Number of HSP's that attempted gapping in prelim test: 4297
Number of HSP's gapped (non-prelim): 221
length of query: 777
length of database: 18,247,518
effective HSP length: 110
effective length of query: 667
effective length of database: 14,082,258
effective search space: 9392866086
effective search space used: 9392866086
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.