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Search of human proteins with 195972873
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens]
(1002 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens] 2029 0.0
gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens] 2025 0.0
gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens] 1935 0.0
gi|78499633 phospholipase C, eta 2 [Homo sapiens] 1211 0.0
gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens] 344 3e-94
gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens] 344 3e-94
gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens] 339 9e-93
gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens] 339 9e-93
gi|14249340 phospholipase C, delta 4 [Homo sapiens] 337 4e-92
gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens] 330 5e-90
gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens] 330 5e-90
gi|117168250 phospholipase C, epsilon 1 [Homo sapiens] 307 3e-83
gi|19115964 phospholipase C delta 3 [Homo sapiens] 295 1e-79
gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens] 293 6e-79
gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens] 293 6e-79
gi|11386139 phospholipase C beta 3 [Homo sapiens] 285 1e-76
gi|25188201 phospholipase C, zeta 1 [Homo sapiens] 244 3e-64
gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 239 1e-62
gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 239 1e-62
gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 235 2e-61
gi|12083581 phosphoinositide-specific phospholipase C beta 1 iso... 174 4e-43
gi|33356544 phosphoinositide-specific phospholipase C beta 1 iso... 174 4e-43
gi|95147333 phospholipase C, beta 2 [Homo sapiens] 169 1e-41
gi|209862851 plastin 3 [Homo sapiens] 45 3e-04
gi|7549809 plastin 3 [Homo sapiens] 45 3e-04
gi|11067753 calcium binding protein 5 [Homo sapiens] 45 4e-04
gi|223278387 calmodulin-like 5 [Homo sapiens] 44 6e-04
gi|4885111 calmodulin-like 3 [Homo sapiens] 44 0.001
gi|58218968 calmodulin 3 [Homo sapiens] 42 0.003
gi|4502549 calmodulin 2 [Homo sapiens] 42 0.003
>gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens]
Length = 1002
Score = 2029 bits (5257), Expect = 0.0
Identities = 1002/1002 (100%), Positives = 1002/1002 (100%)
Query: 1 MADLEVYKNLSPEKVERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSE 60
MADLEVYKNLSPEKVERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSE
Sbjct: 1 MADLEVYKNLSPEKVERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSE 60
Query: 61 KAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWI 120
KAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWI
Sbjct: 61 KAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWI 120
Query: 121 TGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPR 180
TGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPR
Sbjct: 121 TGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPR 180
Query: 181 RKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFL 240
RKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFL
Sbjct: 181 RKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFL 240
Query: 241 KVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQD 300
KVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQD
Sbjct: 241 KVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQD 300
Query: 301 MDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHG 360
MDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHG
Sbjct: 301 MDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHG 360
Query: 361 YTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSS 420
YTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSS
Sbjct: 361 YTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSS 420
Query: 421 VDTGECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSN 480
VDTGECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSN
Sbjct: 421 VDTGECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSN 480
Query: 481 GTTEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESG 540
GTTEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESG
Sbjct: 481 GTTEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESG 540
Query: 541 KKSHGRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRE 600
KKSHGRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRE
Sbjct: 541 KKSHGRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRE 600
Query: 601 LSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY 660
LSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY
Sbjct: 601 LSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY 660
Query: 661 RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNP 720
RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNP
Sbjct: 661 RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNP 720
Query: 721 FSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTR 780
FSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTR
Sbjct: 721 FSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTR 780
Query: 781 VVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVY 840
VVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVY
Sbjct: 781 VVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVY 840
Query: 841 LEGLTEASIFVHITINEIYGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHSS 900
LEGLTEASIFVHITINEIYGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHSS
Sbjct: 841 LEGLTEASIFVHITINEIYGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHSS 900
Query: 901 SENNSHYVRKRSIGDRILRRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRT 960
SENNSHYVRKRSIGDRILRRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRT
Sbjct: 901 SENNSHYVRKRSIGDRILRRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRT 960
Query: 961 TRSLQARPVSMPVDRNLLGALSLPVSETAKDIEGKENSLVQI 1002
TRSLQARPVSMPVDRNLLGALSLPVSETAKDIEGKENSLVQI
Sbjct: 961 TRSLQARPVSMPVDRNLLGALSLPVSETAKDIEGKENSLVQI 1002
>gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens]
Length = 1693
Score = 2025 bits (5246), Expect = 0.0
Identities = 999/1001 (99%), Positives = 1000/1001 (99%)
Query: 1 MADLEVYKNLSPEKVERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSE 60
MADLEVYKNLSPEKVERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSE
Sbjct: 1 MADLEVYKNLSPEKVERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSE 60
Query: 61 KAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWI 120
KAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWI
Sbjct: 61 KAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWI 120
Query: 121 TGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPR 180
TGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPR
Sbjct: 121 TGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPR 180
Query: 181 RKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFL 240
RKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFL
Sbjct: 181 RKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFL 240
Query: 241 KVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQD 300
KVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQD
Sbjct: 241 KVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQD 300
Query: 301 MDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHG 360
MDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHG
Sbjct: 301 MDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHG 360
Query: 361 YTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSS 420
YTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSS
Sbjct: 361 YTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSS 420
Query: 421 VDTGECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSN 480
VDTGECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSN
Sbjct: 421 VDTGECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSN 480
Query: 481 GTTEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESG 540
GTTEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESG
Sbjct: 481 GTTEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESG 540
Query: 541 KKSHGRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRE 600
KKSHGRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRE
Sbjct: 541 KKSHGRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRE 600
Query: 601 LSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY 660
LSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY
Sbjct: 601 LSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY 660
Query: 661 RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNP 720
RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNP
Sbjct: 661 RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNP 720
Query: 721 FSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTR 780
FSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTR
Sbjct: 721 FSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTR 780
Query: 781 VVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVY 840
VVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVY
Sbjct: 781 VVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVY 840
Query: 841 LEGLTEASIFVHITINEIYGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHSS 900
LEGLTEASIFVHITINEIYGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHSS
Sbjct: 841 LEGLTEASIFVHITINEIYGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHSS 900
Query: 901 SENNSHYVRKRSIGDRILRRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRT 960
SENNSHYVRKRSIGDRILRRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRT
Sbjct: 901 SENNSHYVRKRSIGDRILRRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRT 960
Query: 961 TRSLQARPVSMPVDRNLLGALSLPVSETAKDIEGKENSLVQ 1001
TRSLQARPVSMPVDRNLLGALSLPVSETAKDIEGKENSL +
Sbjct: 961 TRSLQARPVSMPVDRNLLGALSLPVSETAKDIEGKENSLAE 1001
>gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens]
Length = 1655
Score = 1935 bits (5012), Expect = 0.0
Identities = 961/983 (97%), Positives = 962/983 (97%), Gaps = 20/983 (2%)
Query: 19 MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQS 78
MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQS
Sbjct: 1 MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQS 60
Query: 79 EIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAK 138
EIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAK
Sbjct: 61 EIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAK 120
Query: 139 RQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGT 198
RQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGT
Sbjct: 121 RQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGT 180
Query: 199 LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDII 258
LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDII
Sbjct: 181 LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDII 240
Query: 259 KKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYL 318
KKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYL
Sbjct: 241 KKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYL 300
Query: 319 TGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINK 378
TGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINK
Sbjct: 301 TGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINK 360
Query: 379 HAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGK 438
HAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGK
Sbjct: 361 HAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGK 420
Query: 439 ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESL 498
ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESL
Sbjct: 421 ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESL 480
Query: 499 LKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSHGRSLMTNFGKHKKT 558
LKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSHGRSLMTNFGKHKKT
Sbjct: 481 LKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSHGRSLMTNFGKHKKT 540
Query: 559 TKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVD 618
TKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVD
Sbjct: 541 TKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVD 600
Query: 619 DGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQ 678
DGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQ
Sbjct: 601 DGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQ 660
Query: 679 LVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKV 738
LVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKV
Sbjct: 661 LVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKV 720
Query: 739 ISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFT 798
ISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFT
Sbjct: 721 ISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFT 780
Query: 799 VHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEI 858
VHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEI
Sbjct: 781 VHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEI 840
Query: 859 YGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHSSSENNSHYVRKRSIGDRIL 918
YG KNRQLQGLKGLFNKNPRHSSSENNSHYVRKRSIGDRIL
Sbjct: 841 YG--------------------KNRQLQGLKGLFNKNPRHSSSENNSHYVRKRSIGDRIL 880
Query: 919 RRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRTTRSLQARPVSMPVDRNLL 978
RRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRTTRSLQARPVSMPVDRNLL
Sbjct: 881 RRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRTTRSLQARPVSMPVDRNLL 940
Query: 979 GALSLPVSETAKDIEGKENSLVQ 1001
GALSLPVSETAKDIEGKENSL +
Sbjct: 941 GALSLPVSETAKDIEGKENSLAE 963
>gi|78499633 phospholipase C, eta 2 [Homo sapiens]
Length = 1416
Score = 1211 bits (3133), Expect = 0.0
Identities = 599/944 (63%), Positives = 741/944 (78%), Gaps = 30/944 (3%)
Query: 15 VERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTE 74
VERCM MQ G QM+KL+ G+KGLVR +YLDEHR+ +RWRPSRK+EKAKI IDSI +V+E
Sbjct: 42 VERCMGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRKNEKAKISIDSIQEVSE 101
Query: 75 GRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDED 134
GRQSE+F R +G+FDP+CCF+IYHG+H ESLDL++++ E ARTW+TGL+YLMAGISDED
Sbjct: 102 GRQSEVFQRYPDGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDED 161
Query: 135 SLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDE 194
SLA+RQRT DQW+KQTF+EADKNGDG L+I E+ QL+HKLNVNLPR++V+QMF+EADTD+
Sbjct: 162 SLARRQRTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREADTDD 221
Query: 195 NQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYC 254
+QGTL FEEFC FYKMMS RRDLYLL+L+YS+ KDHL L +FL+VEQKM VT + C
Sbjct: 222 HQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTLESC 281
Query: 255 LDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSH 314
DII++FE ENK K +LGI+GFTN+ RSPA DIFNP HH V+QDM QPL +Y+I SSH
Sbjct: 282 QDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSH 341
Query: 315 NTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVE 374
NTYL GDQL+SQS+VDMYA VLQ GCRCVEVDCWDGPDGEP+VHHGYTLTSKILF+DV+E
Sbjct: 342 NTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIE 401
Query: 375 TINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQS 434
TINK+AF+KNE+PVILSIENHCS+ QQ+K+AQYL I GDKLDLSSV + + LPSPQ
Sbjct: 402 TINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQM 461
Query: 435 LKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKK 494
LKGKILVKGKKLP ++ +DAEEGEVSDEDSADEI+D+CK L+ T +VE+ ++K
Sbjct: 462 LKGKILVKGKKLPANISEDAEEGEVSDEDSADEIDDDCKL-LNGDASTNRKRVENTAKRK 520
Query: 495 LESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKE--SGKKSHGRSLMTNF 552
L+SL+KES+IRD EDP++F+V L + G + ++ + E + +GR ++ +F
Sbjct: 521 LDSLIKESKIRDCEDPNNFSVSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSF 580
Query: 553 GKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVA 612
+ KK K+ S ++ ++ Q S GGQ R++KTMKL R LSDLV YT SVA
Sbjct: 581 SRRKKKGSKLKKAASVEEGDEGQDS---PGGQSRGATRQKKTMKLSRALSDLVKYTKSVA 637
Query: 613 AQDI-VDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLP 671
DI ++ ++ V SFSET+AHQ++QQK Q++ +NQ+QL+RIYPS+YR+DSSN+NP P
Sbjct: 638 THDIEMEAASSWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQP 697
Query: 672 YWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDPLPANPK 731
+WNAGCQ+VALNYQSEGRM+QLNRAKF ANG CGYVLKP MC+G FNP S DPLP K
Sbjct: 698 FWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQGVFNPNSEDPLPGQLK 757
Query: 732 KQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVW 791
KQL+L++ISGQQLPKP DSM GDRGEIIDPFVEVEIIGLPVDC ++QTRVVDDNGFNP W
Sbjct: 758 KQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTW 817
Query: 792 EETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFV 851
EETL F VHMPEIALVRFLVWDHDPIGRDF+GQRT+ FSS++PGYRHVYLEG+ EASIFV
Sbjct: 818 EETLVFMVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYLEGMEEASIFV 877
Query: 852 HITINEIYGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHSSSENNS--HYVR 909
H+ +++I G K +Q GLKGLF + P+ S ++++
Sbjct: 878 HVAVSDISG--------------------KVKQALGLKGLFLRGPKPGSLDSHAAGRPPA 917
Query: 910 KRSIGDRILRRTASAPAKGRKKSKMGFQEMV-EIKDSVSEATRD 952
+ S+ RILRRTASAP K +K + GF E+V +D+ S+ D
Sbjct: 918 RPSVSQRILRRTASAPTKSQKPGRRGFPELVLGTRDTGSKGVAD 961
>gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens]
Length = 1127
Score = 344 bits (882), Expect = 3e-94
Identities = 189/457 (41%), Positives = 279/457 (61%), Gaps = 9/457 (1%)
Query: 18 CMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRK-SEKAKILIDSIYKVTEGR 76
C++ M G+++ K++ ++ R F LD LRW PS+K SEKAKI I SI +V G+
Sbjct: 139 CINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGK 198
Query: 77 QSEIFHRQA-EGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMA-GISDED 134
++IF C F++ +G + ESLDL+ ++ + A W+TGL+YL++ G D
Sbjct: 199 NTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLD 258
Query: 135 SLAKRQ-RTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTD 193
L Q WV Q F E D + G + + Q + LN L K+ F+E
Sbjct: 259 MLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKS 318
Query: 194 ENQ-GT-LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTT 251
+++ GT +T EEF + + R ++Y LL+ +S K+ L ++L FL+ EQ + ++
Sbjct: 319 KDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINE 378
Query: 252 DYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIA 311
+ L+II K+E S+E + K L I+GFTN++ SP C IF+P H +V QDM QPL +Y+I
Sbjct: 379 EISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFIN 438
Query: 312 SSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRD 371
SSHNTYL DQ S + Y R L+ GCR VE+D WDGPD EPV++ G+T+TS+I+FR
Sbjct: 439 SSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRS 498
Query: 372 VVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPS 431
V++ INK+AF +E+P+IL +ENHCSI+QQ+ + Q++K + GDKL +S + E LPS
Sbjct: 499 VIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEE-SYLPS 557
Query: 432 PQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEI 468
P LKGKIL+K KKL + EG+V+DED E+
Sbjct: 558 PDVLKGKILIKAKKLSSNC--SGVEGDVTDEDEGAEM 592
Score = 227 bits (578), Expect = 5e-59
Identities = 130/331 (39%), Positives = 188/331 (56%), Gaps = 23/331 (6%)
Query: 553 GKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRR---------KTMKLCRELSD 603
GK K S + S + + T + G E Q R+G+ K +LC+ELS+
Sbjct: 563 GKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQ--RMGKENMEQPNNVPVKRFQLCKELSE 620
Query: 604 LVVYTNSVAAQDIVDDGTTGN---VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY 660
LV SV ++ V SF+E A + + F+ YN++ L R++PS
Sbjct: 621 LVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPM 680
Query: 661 RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT--F 718
RIDSSN NP +W GCQ+VA+N+Q+ G MM LN F+ NGNCGYVL+P M + F
Sbjct: 681 RIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFF 740
Query: 719 NPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQ 778
+ + D +P + L +K+ISGQ PKP S G +G+++DP+V VEI G+P DC + +
Sbjct: 741 SANTKDSVPGVSPQLLHIKIISGQNFPKPKGS--GAKGDVVDPYVYVEIHGIPADCAEQR 798
Query: 779 TRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRH 838
T+ V NG P+++E+ F +++PE+A+VRF+V D D IG +F+GQ T+ F L GYRH
Sbjct: 799 TKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRH 858
Query: 839 VYLEGLT-----EASIFVHITINEIYGKWSP 864
V L+ LT AS+FVH+ I G P
Sbjct: 859 VPLQSLTGEVLAHASLFVHVAITNRRGGGKP 889
>gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens]
Length = 1001
Score = 344 bits (882), Expect = 3e-94
Identities = 189/457 (41%), Positives = 279/457 (61%), Gaps = 9/457 (1%)
Query: 18 CMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRK-SEKAKILIDSIYKVTEGR 76
C++ M G+++ K++ ++ R F LD LRW PS+K SEKAKI I SI +V G+
Sbjct: 13 CINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGK 72
Query: 77 QSEIFHRQA-EGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMA-GISDED 134
++IF C F++ +G + ESLDL+ ++ + A W+TGL+YL++ G D
Sbjct: 73 NTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLD 132
Query: 135 SLAKRQ-RTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTD 193
L Q WV Q F E D + G + + Q + LN L K+ F+E
Sbjct: 133 MLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKS 192
Query: 194 ENQ-GT-LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTT 251
+++ GT +T EEF + + R ++Y LL+ +S K+ L ++L FL+ EQ + ++
Sbjct: 193 KDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINE 252
Query: 252 DYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIA 311
+ L+II K+E S+E + K L I+GFTN++ SP C IF+P H +V QDM QPL +Y+I
Sbjct: 253 EISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFIN 312
Query: 312 SSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRD 371
SSHNTYL DQ S + Y R L+ GCR VE+D WDGPD EPV++ G+T+TS+I+FR
Sbjct: 313 SSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRS 372
Query: 372 VVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPS 431
V++ INK+AF +E+P+IL +ENHCSI+QQ+ + Q++K + GDKL +S + E LPS
Sbjct: 373 VIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEE-SYLPS 431
Query: 432 PQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEI 468
P LKGKIL+K KKL + EG+V+DED E+
Sbjct: 432 PDVLKGKILIKAKKLSSNC--SGVEGDVTDEDEGAEM 466
Score = 227 bits (578), Expect = 5e-59
Identities = 130/331 (39%), Positives = 188/331 (56%), Gaps = 23/331 (6%)
Query: 553 GKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRR---------KTMKLCRELSD 603
GK K S + S + + T + G E Q R+G+ K +LC+ELS+
Sbjct: 437 GKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQ--RMGKENMEQPNNVPVKRFQLCKELSE 494
Query: 604 LVVYTNSVAAQDIVDDGTTGN---VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY 660
LV SV ++ V SF+E A + + F+ YN++ L R++PS
Sbjct: 495 LVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPM 554
Query: 661 RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT--F 718
RIDSSN NP +W GCQ+VA+N+Q+ G MM LN F+ NGNCGYVL+P M + F
Sbjct: 555 RIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFF 614
Query: 719 NPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQ 778
+ + D +P + L +K+ISGQ PKP S G +G+++DP+V VEI G+P DC + +
Sbjct: 615 SANTKDSVPGVSPQLLHIKIISGQNFPKPKGS--GAKGDVVDPYVYVEIHGIPADCAEQR 672
Query: 779 TRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRH 838
T+ V NG P+++E+ F +++PE+A+VRF+V D D IG +F+GQ T+ F L GYRH
Sbjct: 673 TKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRH 732
Query: 839 VYLEGLT-----EASIFVHITINEIYGKWSP 864
V L+ LT AS+FVH+ I G P
Sbjct: 733 VPLQSLTGEVLAHASLFVHVAITNRRGGGKP 763
>gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens]
Length = 1095
Score = 339 bits (869), Expect = 9e-93
Identities = 196/497 (39%), Positives = 293/497 (58%), Gaps = 12/497 (2%)
Query: 18 CMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKS-EKAKILIDSIYKVTEGR 76
C+S MQ+G ++ K++ ++ R F LD LRW PS+K EKAK+ I +I ++ G+
Sbjct: 111 CISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGK 170
Query: 77 QSEIFHRQAEGN-FDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDE-D 134
+E F + C F+I HG + ESLDL+ ++ + A W++GL+YL++ D
Sbjct: 171 NTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLD 230
Query: 135 SLAKRQRT-HDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTD 193
+ Q T W+K FE AD +G+G++ + +L+ +LN L K+R F+E
Sbjct: 231 FMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKS 290
Query: 194 ENQGT--LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTT 251
+ + T +T EEFC + + R ++Y LL+ S K++L +L FL+ EQ + ++T
Sbjct: 291 KEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITE 350
Query: 252 DYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIA 311
D CLDII+++E+SEE + K L I+GFT ++ S CDIF+P +V QDM QPL +YYI
Sbjct: 351 DICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYIN 410
Query: 312 SSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRD 371
+SHNTYL DQ + ++ Y R L+ GCR VE+D DG D EP++ + +T+ + FR
Sbjct: 411 ASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRS 470
Query: 372 VVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPS 431
V+E INK AFV +E+P+IL + NHCS+ QQ+ +AQ +K +FG+KL + E LPS
Sbjct: 471 VIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSE-SYLPS 529
Query: 432 PQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFI 491
P+ LK I+VKGKKLP D EGEV+DED +E E + + Y NG +
Sbjct: 530 PEKLKRMIIVKGKKLP--SDPDVLEGEVTDED--EEAEMSRRMSVDY-NGEQKQIRLCRE 584
Query: 492 RKKLESLLKESQIRDKE 508
L S+ K Q RD E
Sbjct: 585 LSDLVSICKSVQYRDFE 601
Score = 233 bits (594), Expect = 7e-61
Identities = 129/304 (42%), Positives = 182/304 (59%), Gaps = 18/304 (5%)
Query: 568 TDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGN--- 624
TD++E+ + S +K ++LCRELSDLV SV +D + N
Sbjct: 556 TDEDEEAEMSRRMS----VDYNGEQKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWE 611
Query: 625 VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNY 684
+ SFSET A ++ + E F+ YN+K L+RIYPSA RIDSSN NP +WN GCQ+VA+N+
Sbjct: 612 MCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNF 671
Query: 685 QSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDP---LPANPKKQLILKVISG 741
Q+ G MM L+ F NG CGYVL+P M + + FS + LP L +K+ISG
Sbjct: 672 QTPGPMMDLHTGWFLQNGGCGYVLRPSIM-RDEVSYFSANTKGILPGVSPLALHIKIISG 730
Query: 742 QQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHM 801
Q PKP + +G++IDP+V +EI G+P DC + +T+ V N NP+++ET F V++
Sbjct: 731 QNFPKPKGAC--AKGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNL 788
Query: 802 PEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEG-----LTEASIFVHITIN 856
PE+A++RF+V D D IG +F+GQ T+ F L PGYRHV L + ++FVHI I
Sbjct: 789 PELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAIT 848
Query: 857 EIYG 860
G
Sbjct: 849 NRSG 852
>gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens]
Length = 997
Score = 339 bits (869), Expect = 9e-93
Identities = 196/497 (39%), Positives = 293/497 (58%), Gaps = 12/497 (2%)
Query: 18 CMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKS-EKAKILIDSIYKVTEGR 76
C+S MQ+G ++ K++ ++ R F LD LRW PS+K EKAK+ I +I ++ G+
Sbjct: 13 CISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGK 72
Query: 77 QSEIFHRQAEGN-FDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDE-D 134
+E F + C F+I HG + ESLDL+ ++ + A W++GL+YL++ D
Sbjct: 73 NTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLD 132
Query: 135 SLAKRQRT-HDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTD 193
+ Q T W+K FE AD +G+G++ + +L+ +LN L K+R F+E
Sbjct: 133 FMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKS 192
Query: 194 ENQGT--LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTT 251
+ + T +T EEFC + + R ++Y LL+ S K++L +L FL+ EQ + ++T
Sbjct: 193 KEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITE 252
Query: 252 DYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIA 311
D CLDII+++E+SEE + K L I+GFT ++ S CDIF+P +V QDM QPL +YYI
Sbjct: 253 DICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYIN 312
Query: 312 SSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRD 371
+SHNTYL DQ + ++ Y R L+ GCR VE+D DG D EP++ + +T+ + FR
Sbjct: 313 ASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRS 372
Query: 372 VVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPS 431
V+E INK AFV +E+P+IL + NHCS+ QQ+ +AQ +K +FG+KL + E LPS
Sbjct: 373 VIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSE-SYLPS 431
Query: 432 PQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFI 491
P+ LK I+VKGKKLP D EGEV+DED +E E + + Y NG +
Sbjct: 432 PEKLKRMIIVKGKKLP--SDPDVLEGEVTDED--EEAEMSRRMSVDY-NGEQKQIRLCRE 486
Query: 492 RKKLESLLKESQIRDKE 508
L S+ K Q RD E
Sbjct: 487 LSDLVSICKSVQYRDFE 503
Score = 233 bits (594), Expect = 7e-61
Identities = 129/304 (42%), Positives = 182/304 (59%), Gaps = 18/304 (5%)
Query: 568 TDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGN--- 624
TD++E+ + S +K ++LCRELSDLV SV +D + N
Sbjct: 458 TDEDEEAEMSRRMS----VDYNGEQKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWE 513
Query: 625 VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNY 684
+ SFSET A ++ + E F+ YN+K L+RIYPSA RIDSSN NP +WN GCQ+VA+N+
Sbjct: 514 MCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNF 573
Query: 685 QSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDP---LPANPKKQLILKVISG 741
Q+ G MM L+ F NG CGYVL+P M + + FS + LP L +K+ISG
Sbjct: 574 QTPGPMMDLHTGWFLQNGGCGYVLRPSIM-RDEVSYFSANTKGILPGVSPLALHIKIISG 632
Query: 742 QQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHM 801
Q PKP + +G++IDP+V +EI G+P DC + +T+ V N NP+++ET F V++
Sbjct: 633 QNFPKPKGAC--AKGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNL 690
Query: 802 PEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEG-----LTEASIFVHITIN 856
PE+A++RF+V D D IG +F+GQ T+ F L PGYRHV L + ++FVHI I
Sbjct: 691 PELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAIT 750
Query: 857 EIYG 860
G
Sbjct: 751 NRSG 754
>gi|14249340 phospholipase C, delta 4 [Homo sapiens]
Length = 762
Score = 337 bits (863), Expect = 4e-92
Identities = 187/456 (41%), Positives = 277/456 (60%), Gaps = 7/456 (1%)
Query: 21 VMQSGTQMIKLKRGTKGLVRLFYL-DEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQSE 79
+MQ G M K++ + +R F L ++ T R +R S K I + + G SE
Sbjct: 17 LMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSE 76
Query: 80 IFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKR 139
+ AE FTI +LDL+ ++ EEA+ W+ GL+ L+ ++ D
Sbjct: 77 LLRSLAE-ELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMD----H 131
Query: 140 QRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTL 199
Q DQW+ F+ DKN DG ++ +E+ +L+H +NV + + +FQ ADT ++ GTL
Sbjct: 132 QERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAADTSQS-GTL 190
Query: 200 TFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDIIK 259
EEF FYK ++ R ++ L S+S LT+ E FL+ EQK + T++ L++I
Sbjct: 191 EGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELID 250
Query: 260 KFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLT 319
++E S+ K+++VL ++GF +++ S DIFNP +YQDM QPL +Y+I SSHNTYL
Sbjct: 251 RYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSHNTYLV 310
Query: 320 GDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKH 379
GDQL QS V+ Y R L+ GCRCVEVD WDGP GEPVV+HG+TLTS+ILF+DVV T+ ++
Sbjct: 311 GDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVATVAQY 370
Query: 380 AFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKI 439
AF +++PVILS+E HCS +QQ+ +A++L I G++L +++D QLPSP+ L+ KI
Sbjct: 371 AFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEELRRKI 430
Query: 440 LVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFK 475
LVKGKKL + EE E E E+ E +F+
Sbjct: 431 LVKGKKLTLEEDLEYEEEEAEPELEESELALESQFE 466
Score = 209 bits (531), Expect = 1e-53
Identities = 118/303 (38%), Positives = 180/303 (59%), Gaps = 23/303 (7%)
Query: 566 YSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGN- 624
+ T+ E Q K+ +++ LC LS LV+Y SV+ + +
Sbjct: 465 FETEPEPQEQNLQNKDK-------KKKSKPILCPALSSLVIYLKSVSFRSFTHSKEHYHF 517
Query: 625 --VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVAL 682
+ SFSET+A +++++ +F+ +N QL+R+YPS R DSSN+NP WNAGCQ+VA+
Sbjct: 518 YEISSFSETKAKRLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAM 577
Query: 683 NYQSEGRMMQLNRAKFKANGNCGYVLKPQQM--CKGTFNPFSGDPLPANPKKQLILKVIS 740
N Q+ G M + F+ NG CGYVLKP + + +F+P P+ + L+++VIS
Sbjct: 578 NMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRDIQSSFHP--EKPISPFKAQTLLIQVIS 635
Query: 741 GQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVH 800
GQQLPK + G I+DP V+V+I G+ +D + +T V++NGFNP W +TL F V
Sbjct: 636 GQQLPKVDKT---KEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPYWGQTLCFRVL 692
Query: 801 MPEIALVRFLVWDHDPIGR-DFVGQRTVTFSSLVPGYRHVYL-----EGLTEASIFVHIT 854
+PE+A++RF+V D+D R DF+GQ T+ ++ + GYRH++L L ASIFV+I
Sbjct: 693 VPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRHIHLLSKDGISLRPASIFVYIC 752
Query: 855 INE 857
I E
Sbjct: 753 IQE 755
>gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens]
Length = 1194
Score = 330 bits (845), Expect = 5e-90
Identities = 247/785 (31%), Positives = 387/785 (49%), Gaps = 115/785 (14%)
Query: 108 LITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEI 167
++ NPE + W+ GL+ ++ ++++ W+K F N +G + + I
Sbjct: 114 MVAENPEVTKQWVEGLRSIIHNFR-ANNVSPMTCLKKHWMKLAFMT---NTNGKIPVRSI 169
Query: 168 HQLMHKLNVNLPRRKVRQMFQE-----ADTDENQGT-LTFEEFCVFYKMMSLRRDLYLLL 221
+ + + Q +E DE + T ++E+F + + R D+ L
Sbjct: 170 TRTFAS---GKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLF 226
Query: 222 LSYS-DKKDHLTVEELAQFLKVEQK---MNNVTTDY-----CLDIIKKFEVSEENKVKNV 272
+ DK D+LTV++L FL Q+ +N + + + II+ +E E+ K K +
Sbjct: 227 KKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGL 286
Query: 273 LGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMY 332
+ +GF ++ S E+YQ+MD PL +Y+I+SSHNTYLTG Q +S V+MY
Sbjct: 287 ISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMY 346
Query: 333 ARVLQEGCRCVEVDCWDGP--DGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVIL 390
+VL GCRCVE+DCWDG D EP++ HG + + ILF+DV++ I + AFV +E+PVIL
Sbjct: 347 RQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVIL 406
Query: 391 SIENHCSIQQQRKIAQYLKGIFGD---KLDLSSVDTGECKQLPSPQSLKGKILVKGKKLP 447
S ENHCS QQ K+++Y + +FGD K L S + LPSP LK KIL+K K+L
Sbjct: 407 SFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLK 466
Query: 448 YHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESLLKESQIRDK 507
E+E +K+LE+L + +
Sbjct: 467 ------------------PEVE----------------------KKQLEALRSMMEAGES 486
Query: 508 EDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSH--GRSLMTNFGKHKKTT-KSRSK 564
P + E N +S D +E G L + HK+ S K
Sbjct: 487 ASPANIL---------EDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKK 537
Query: 565 SYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDI---VDDGT 621
T ++E ++ K G T + LS ++ Y V Q +
Sbjct: 538 GLVTVEDEQAWMASYKYVGA---------TTNIHPYLSTMINYAQPVKFQGFHVAEERNI 588
Query: 622 TGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVA 681
N+ SF+E+ ++ + +F+ YN++Q++RIYP R+DSSN+ P +WNAGCQ+V+
Sbjct: 589 HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS 648
Query: 682 LNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCK--GTFNPFSGDPLPANPKKQLILKVI 739
LNYQ+ MQLN+ KF+ NG+CGY+LKP M + TF+PFS P+ ++VI
Sbjct: 649 LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI 708
Query: 740 SGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQ--TRVVDDNGFNPVW-EETLT 796
SGQ L + I +VEV++ GLP D + + TR+V +NG NPV+ EE+
Sbjct: 709 SGQFL----------SDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFV 758
Query: 797 F-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEG-----LTEASIF 850
F V +P++A++R V+D + +GQR + L GYRH+ L L+ +IF
Sbjct: 759 FRKVILPDLAVLRIAVYDDN---NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIF 815
Query: 851 VHITI 855
+I +
Sbjct: 816 CNIVL 820
>gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens]
Length = 1175
Score = 330 bits (845), Expect = 5e-90
Identities = 247/785 (31%), Positives = 387/785 (49%), Gaps = 115/785 (14%)
Query: 108 LITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEI 167
++ NPE + W+ GL+ ++ ++++ W+K F N +G + + I
Sbjct: 114 MVAENPEVTKQWVEGLRSIIHNFR-ANNVSPMTCLKKHWMKLAFMT---NTNGKIPVRSI 169
Query: 168 HQLMHKLNVNLPRRKVRQMFQE-----ADTDENQGT-LTFEEFCVFYKMMSLRRDLYLLL 221
+ + + Q +E DE + T ++E+F + + R D+ L
Sbjct: 170 TRTFAS---GKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLF 226
Query: 222 LSYS-DKKDHLTVEELAQFLKVEQK---MNNVTTDY-----CLDIIKKFEVSEENKVKNV 272
+ DK D+LTV++L FL Q+ +N + + + II+ +E E+ K K +
Sbjct: 227 KKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGL 286
Query: 273 LGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMY 332
+ +GF ++ S E+YQ+MD PL +Y+I+SSHNTYLTG Q +S V+MY
Sbjct: 287 ISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMY 346
Query: 333 ARVLQEGCRCVEVDCWDGP--DGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVIL 390
+VL GCRCVE+DCWDG D EP++ HG + + ILF+DV++ I + AFV +E+PVIL
Sbjct: 347 RQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVIL 406
Query: 391 SIENHCSIQQQRKIAQYLKGIFGD---KLDLSSVDTGECKQLPSPQSLKGKILVKGKKLP 447
S ENHCS QQ K+++Y + +FGD K L S + LPSP LK KIL+K K+L
Sbjct: 407 SFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLK 466
Query: 448 YHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESLLKESQIRDK 507
E+E +K+LE+L + +
Sbjct: 467 ------------------PEVE----------------------KKQLEALRSMMEAGES 486
Query: 508 EDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSH--GRSLMTNFGKHKKTT-KSRSK 564
P + E N +S D +E G L + HK+ S K
Sbjct: 487 ASPANIL---------EDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKK 537
Query: 565 SYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDI---VDDGT 621
T ++E ++ K G T + LS ++ Y V Q +
Sbjct: 538 GLVTVEDEQAWMASYKYVGA---------TTNIHPYLSTMINYAQPVKFQGFHVAEERNI 588
Query: 622 TGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVA 681
N+ SF+E+ ++ + +F+ YN++Q++RIYP R+DSSN+ P +WNAGCQ+V+
Sbjct: 589 HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS 648
Query: 682 LNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCK--GTFNPFSGDPLPANPKKQLILKVI 739
LNYQ+ MQLN+ KF+ NG+CGY+LKP M + TF+PFS P+ ++VI
Sbjct: 649 LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI 708
Query: 740 SGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQ--TRVVDDNGFNPVW-EETLT 796
SGQ L + I +VEV++ GLP D + + TR+V +NG NPV+ EE+
Sbjct: 709 SGQFL----------SDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFV 758
Query: 797 F-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEG-----LTEASIF 850
F V +P++A++R V+D + +GQR + L GYRH+ L L+ +IF
Sbjct: 759 FRKVILPDLAVLRIAVYDDN---NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIF 815
Query: 851 VHITI 855
+I +
Sbjct: 816 CNIVL 820
>gi|117168250 phospholipase C, epsilon 1 [Homo sapiens]
Length = 2302
Score = 307 bits (787), Expect = 3e-83
Identities = 222/667 (33%), Positives = 333/667 (49%), Gaps = 80/667 (11%)
Query: 235 ELAQFLKVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNF-MRSPACDIFNPL 293
+L FL V + + T D L II+KFE S + ++ EGF F M N
Sbjct: 1328 QLNDFL-VNCQGEHCTYDEILSIIQKFEPSISMCHQGLMSFEGFARFLMDKENFASKNDE 1386
Query: 294 HHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDG 353
E +++ PL YYI SSHNTYLTG QL +S V++Y++VL +GCR VE+DCWDG DG
Sbjct: 1387 SQENIKELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDGDDG 1446
Query: 354 EPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFG 413
P+++HG+TLT+KI F++VVE I++ AF+ ++ P+I+SIENHCS+ QQRK+A+ K +FG
Sbjct: 1447 MPIIYHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEIFKTVFG 1506
Query: 414 DKL---DLSSVDTGECKQLPSPQSLKGKILVKGKKLPYHL-------------------- 450
+KL L D + LPSP L+ K+L+K KKL H
Sbjct: 1507 EKLVTKFLFETDFSDDPMLPSPDQLRKKVLLKNKKLKAHQTPVDILKQKAHQLASMQVQA 1566
Query: 451 --GDDAEEGEVSDEDSADEIEDE----------------------CKFKLHYSNGTTEHQ 486
G +A ++E+ DE EDE C KL + +
Sbjct: 1567 YNGGNANPRPANNEEEEDE-EDEYDYDYESLSDDNILEDRPENKSCNDKLQFE---YNEE 1622
Query: 487 VESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHE---GLNAHLKQSPDVKESGKKS 543
+ I+K S + ++ D E + F + K + + L+ + VK G +
Sbjct: 1623 IPKRIKKADNSACNKGKVYDMELGEEFYLDQNKKESRQIAPELSDLVIYCQAVKFPGLST 1682
Query: 544 HGRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSD 603
S ++ GK +K+ KS + S K G+ G R + E S
Sbjct: 1683 LNAS-GSSRGKERKSRKSIFGNNPGRMSPGETASFNKTSGKSSCEGIR----QTWEESSS 1737
Query: 604 LVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRID 663
+ T S++A I+ ++ S +E A ++ ++ S++ + QL R YP+A RID
Sbjct: 1738 PLNPTTSLSA--IIRTPKCYHISSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRID 1795
Query: 664 SSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT------ 717
SSN NPL +W G QLVALNYQ++ + LN A F+ANG CGYVLKP +
Sbjct: 1796 SSNPNPLMFWLHGIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQK 1855
Query: 718 FNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKD 777
F+P D L + L ++SGQ + P +SM P +EV+++G+P+D C
Sbjct: 1856 FSPLERD-LDSMDPAVYSLTIVSGQNV-CPSNSMG-------SPCIEVDVLGMPLDSCHF 1906
Query: 778 QTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYR 837
+T+ + N NP+W E F VH ++ +RF V +++ QR + +L GYR
Sbjct: 1907 RTKPIHRNTLNPMWNEQFLFHVHFEDLVFLRFAVVENN--SSAVTAQRIIPLKALKRGYR 1964
Query: 838 HVYLEGL 844
H+ L L
Sbjct: 1965 HLQLRNL 1971
>gi|19115964 phospholipase C delta 3 [Homo sapiens]
Length = 789
Score = 295 bits (755), Expect = 1e-79
Identities = 171/463 (36%), Positives = 260/463 (56%), Gaps = 15/463 (3%)
Query: 22 MQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRW--RPSRKSEKAKILIDSIYKVTEGRQSE 79
M G+++ K++ T RL+ L E + + R R + + I V EG QSE
Sbjct: 65 MLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAVREGHQSE 124
Query: 80 IFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKR 139
R G F P+ C TI ++LDL EEA+ W+ GL L A + D++++R
Sbjct: 125 GLRRFG-GAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKLRARL---DAMSQR 180
Query: 140 QRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTL 199
+R D W+ AD N D ++ +EI L+ +NV++ +F+E D N L
Sbjct: 181 ERL-DHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECDHSNND-RL 238
Query: 200 TFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDIIK 259
E F + + R +L + YS + L+ EL +FL+ +Q T +I+
Sbjct: 239 EGAEIEEFLRRLLKRPELEEIFHQYSGEDRVLSAPELLEFLE-DQGEEGATLARAQQLIQ 297
Query: 260 KFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLT 319
+E++E K ++ ++GF ++ SP + H V+QDM+QPL +Y+I+SSHNTYLT
Sbjct: 298 TYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLT 357
Query: 320 GDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKH 379
Q+ S + Y R +GCRCVE+DCW+GP GEPV++HG+TLTSKILFRDVV+ + H
Sbjct: 358 DSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVVQAVRDH 417
Query: 380 AFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKI 439
AF + +PVILS+ENHC ++QQ +A++L I GD L ++D+ ++LPSP+ LKG++
Sbjct: 418 AFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEELPSPEQLKGRV 477
Query: 440 LVKGKKLPYHLGDDA------EEGEVSDEDSADEIEDECKFKL 476
LVKGKKLP +D EE E DE+ +E+E + +L
Sbjct: 478 LVKGKKLPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQRRL 520
Score = 209 bits (532), Expect = 1e-53
Identities = 127/339 (37%), Positives = 192/339 (56%), Gaps = 31/339 (9%)
Query: 533 SPDVKESGKKSHGRSLMTNFGKHKKTTKSRSKS-YSTDDEEDTQQSTGKEGGQLYRLGRR 591
+P+ S ++ GR L+ K KK +RS+ + D E+ ++ +E ++ +R
Sbjct: 463 NPEELPSPEQLKGRVLV----KGKKLPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQR 518
Query: 592 RKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGN---VLSFSETRAHQVVQQKSEQFMIYN 648
R ++ ELS L VY ++ + + V S SE +A +++++ F+ +N
Sbjct: 519 RLAKQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHN 578
Query: 649 QKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVL 708
+QLTR+YP R++S+N++P WN+GCQLVALN+Q+ G M LN +F NG CGYVL
Sbjct: 579 ARQLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVL 638
Query: 709 KPQ--QMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPK----PPDSMFGDRGEIIDPF 762
KP + TF+P P P+ L ++V++ QQLPK P S I+DP
Sbjct: 639 KPACLRQPDSTFDP----EYPGPPRTTLSIQVLTAQQLPKLNAEKPHS-------IVDPL 687
Query: 763 VEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIG-RDF 821
V +EI G+P DC + +T V +NGFNP W +TL F + PE+ALVRF+V D+D DF
Sbjct: 688 VRIEIHGVPADCARQETDYVLNNGFNPRWGQTLQFQLRAPELALVRFVVEDYDATSPNDF 747
Query: 822 VGQRTVTFSSLVPGYRHVYL-----EGLTEASIFVHITI 855
VGQ T+ SSL GYRH++L L+ A++F+ I I
Sbjct: 748 VGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLFIQIRI 786
>gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens]
Length = 756
Score = 293 bits (750), Expect = 6e-79
Identities = 170/461 (36%), Positives = 260/461 (56%), Gaps = 16/461 (3%)
Query: 19 MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRK----SEKAKILIDSIYKVTE 74
+ + G+Q++K+K + R + L E + W+ SRK E I+ I +V
Sbjct: 19 LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFSIEDIQEVRM 77
Query: 75 GRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDED 134
G ++E + A + CF+I + +LDLI +P +A+ W+ GL + I
Sbjct: 78 GHRTEGLEKFAR-DVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKI---IHHSG 133
Query: 135 SLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDE 194
S+ +RQ+ W+ +ADKN D ++ +E+ + +LN+ + R++F+E D +
Sbjct: 134 SMDQRQKLQ-HWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQ 192
Query: 195 NQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYC 254
+L EE FYKM++ R ++ + + L+V++L FL+ +Q+
Sbjct: 193 TD-SLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALA 251
Query: 255 LDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSH 314
L +I+++E SE K + + +GF ++ S F+ H VYQDM QPL +Y ++SSH
Sbjct: 252 LSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSH 311
Query: 315 NTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVE 374
NTYL DQL S + Y R L +GCRC+E+DCWDGP+ EP+++HGYT TSKILF DV+
Sbjct: 312 NTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLR 371
Query: 375 TINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQS 434
I +AF + +PVILS+ENHC+++QQR +A++L I G L +D G LPSP+
Sbjct: 372 AIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLD-GVTNSLPSPEQ 430
Query: 435 LKGKILVKGKKLPYHLGDDAEEGE----VSDEDSADEIEDE 471
LKGKIL+KGKKL L E G VSDED A E+EDE
Sbjct: 431 LKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDE 471
Score = 210 bits (534), Expect = 6e-54
Identities = 117/275 (42%), Positives = 171/275 (62%), Gaps = 16/275 (5%)
Query: 595 MKLCRELSDLVVYTNSVAAQDIVDDGTTGNVL----SFSETRAHQVVQQKSEQFMIYNQK 650
++L +ELSD+V+Y SV GT G SFSE RA +++Q+ F+ +N
Sbjct: 486 LRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVG 545
Query: 651 QLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKP 710
L+RIYP+ +R DSSN++P+ WN GCQ+VALN+Q+ G M + + +F+ NG CGYVLKP
Sbjct: 546 HLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKP 605
Query: 711 QQM--CKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEII 768
+ GTFNP + P +K+L ++VISGQQLPK + ++ I+DP V VEI
Sbjct: 606 AFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPK----VNKNKNSIVDPKVTVEIH 661
Query: 769 GLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGR-DFVGQRTV 827
G+ D QT V+ +NGFNP W+ F V +P++AL+RFLV D+D + DF+GQ T+
Sbjct: 662 GVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTI 721
Query: 828 TFSSLVPGYRHVYL-----EGLTEASIFVHITINE 857
+SL GYRHV+L + A++FV I++ +
Sbjct: 722 PLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD 756
>gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens]
Length = 777
Score = 293 bits (750), Expect = 6e-79
Identities = 170/461 (36%), Positives = 260/461 (56%), Gaps = 16/461 (3%)
Query: 19 MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRK----SEKAKILIDSIYKVTE 74
+ + G+Q++K+K + R + L E + W+ SRK E I+ I +V
Sbjct: 40 LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFSIEDIQEVRM 98
Query: 75 GRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDED 134
G ++E + A + CF+I + +LDLI +P +A+ W+ GL + I
Sbjct: 99 GHRTEGLEKFAR-DVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKI---IHHSG 154
Query: 135 SLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDE 194
S+ +RQ+ W+ +ADKN D ++ +E+ + +LN+ + R++F+E D +
Sbjct: 155 SMDQRQKLQ-HWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQ 213
Query: 195 NQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYC 254
+L EE FYKM++ R ++ + + L+V++L FL+ +Q+
Sbjct: 214 TD-SLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALA 272
Query: 255 LDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSH 314
L +I+++E SE K + + +GF ++ S F+ H VYQDM QPL +Y ++SSH
Sbjct: 273 LSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSH 332
Query: 315 NTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVE 374
NTYL DQL S + Y R L +GCRC+E+DCWDGP+ EP+++HGYT TSKILF DV+
Sbjct: 333 NTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLR 392
Query: 375 TINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQS 434
I +AF + +PVILS+ENHC+++QQR +A++L I G L +D G LPSP+
Sbjct: 393 AIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLD-GVTNSLPSPEQ 451
Query: 435 LKGKILVKGKKLPYHLGDDAEEGE----VSDEDSADEIEDE 471
LKGKIL+KGKKL L E G VSDED A E+EDE
Sbjct: 452 LKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDE 492
Score = 210 bits (534), Expect = 6e-54
Identities = 117/275 (42%), Positives = 171/275 (62%), Gaps = 16/275 (5%)
Query: 595 MKLCRELSDLVVYTNSVAAQDIVDDGTTGNVL----SFSETRAHQVVQQKSEQFMIYNQK 650
++L +ELSD+V+Y SV GT G SFSE RA +++Q+ F+ +N
Sbjct: 507 LRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVG 566
Query: 651 QLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKP 710
L+RIYP+ +R DSSN++P+ WN GCQ+VALN+Q+ G M + + +F+ NG CGYVLKP
Sbjct: 567 HLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKP 626
Query: 711 QQM--CKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEII 768
+ GTFNP + P +K+L ++VISGQQLPK + ++ I+DP V VEI
Sbjct: 627 AFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPK----VNKNKNSIVDPKVTVEIH 682
Query: 769 GLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGR-DFVGQRTV 827
G+ D QT V+ +NGFNP W+ F V +P++AL+RFLV D+D + DF+GQ T+
Sbjct: 683 GVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTI 742
Query: 828 TFSSLVPGYRHVYL-----EGLTEASIFVHITINE 857
+SL GYRHV+L + A++FV I++ +
Sbjct: 743 PLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD 777
>gi|11386139 phospholipase C beta 3 [Homo sapiens]
Length = 1234
Score = 285 bits (730), Expect = 1e-76
Identities = 227/665 (34%), Positives = 328/665 (49%), Gaps = 71/665 (10%)
Query: 200 TFEEFCVFYKMMSLRRDLYLLLLSYSDK-KDHLTVEELAQFLKVEQK---MNNVT----- 250
+ E F F + LR D+ +LL K K +LT+E+L F+ +Q+ +N V
Sbjct: 209 SLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLR 268
Query: 251 TDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYI 310
+I+K+E +++ ++ + +EGF+ ++ I ++ DM QPL Y+I
Sbjct: 269 PSQARLLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFI 328
Query: 311 ASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDG--PDGEPVVHHGYTLTSKIL 368
SSHNTYLT QL S V+MY + L GCRCVE+D W G P+ EP + HG+T+T+++
Sbjct: 329 NSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVP 388
Query: 369 FRDVVETINKHAFVKNEFPVILSIENHC-SIQQQRKIAQYLKGIFGDKLDLSSVD---TG 424
RDV+E I + AF + +PVILS ENH S +QQ K+A+Y + IFGD L + +D
Sbjct: 389 LRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLA 448
Query: 425 ECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTE 484
LPSPQ L G+ILVK KK DSA K L SN
Sbjct: 449 PGVPLPSPQDLMGRILVKNKK--------RHRPSAGGPDSAGR-----KRPLEQSNSALS 495
Query: 485 HQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSH 544
S E P S + L GL + P ++ +KS
Sbjct: 496 E----------SSAATEPSSPQLGSPSSDSCPGLSNGEEVGL-----EKPSLEP--QKSL 538
Query: 545 GRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDL 604
G + N G + R +DEE+ +Q+ K+ G + E+S L
Sbjct: 539 GDEGL-NRGPYVLGPADRED--EEEDEEEEEQTDPKK--PTTDEGTASSEVNATEEMSTL 593
Query: 605 VVYTNSVAAQDIV---DDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYR 661
V Y V + + SF ET+A + + + +F+ YN++QL+RIYP R
Sbjct: 594 VNYIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTR 653
Query: 662 IDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCK--GTFN 719
+DSSN+ P +WN GCQLVALN+Q+ MQLN F+ NG GY+LKP+ M + +F+
Sbjct: 654 VDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFD 713
Query: 720 PFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDC-CKDQ 778
PF+ + L +KVISGQ L DR + +VEV++ GLPVD K +
Sbjct: 714 PFTEVIVDGIVANALRVKVISGQFL--------SDRK--VGIYVEVDMFGLPVDTRRKYR 763
Query: 779 TRVVDDNGFNPVW-EETLTF-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGY 836
TR N FNPVW EE F V +P +A +R ++ G FVG R + S++ GY
Sbjct: 764 TRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEE---GGKFVGHRILPVSAIRSGY 820
Query: 837 RHVYL 841
+V L
Sbjct: 821 HYVCL 825
>gi|25188201 phospholipase C, zeta 1 [Homo sapiens]
Length = 608
Score = 244 bits (623), Expect = 3e-64
Identities = 125/287 (43%), Positives = 187/287 (65%), Gaps = 2/287 (0%)
Query: 160 GLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYL 219
G +N+E+ +L+ KL++ V+Q+F++ D + QG +T EEF Y++++ R ++
Sbjct: 17 GKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLK-QGRITIEEFRAIYRIITHREEIIE 75
Query: 220 LLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFT 279
+ +YS+ + L LAQFL EQ ++ +II+K+E EE + + + +EGFT
Sbjct: 76 IFNTYSENRKILLASNLAQFLTQEQYAAEMSKAIAFEIIQKYEPIEEVRKAHQMSLEGFT 135
Query: 280 NFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEG 339
+M S C +F +VYQDM PL +Y+I+SSHNTYL DQLL S + Y L +G
Sbjct: 136 RYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKG 195
Query: 340 CRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQ 399
CRC+E+DCWDG EPVV+HGYTLTSK+LF+ V++ I+K+AF+ +++PV+LS+ENHCS
Sbjct: 196 CRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHCSTA 255
Query: 400 QQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKILVKGKKL 446
QQ +A L+ FG+ L LS + LPSP++LK KILVK KK+
Sbjct: 256 QQEVMADNLQATFGESL-LSDMLDDFPDTLPSPEALKFKILVKNKKI 301
Score = 187 bits (475), Expect = 4e-47
Identities = 118/313 (37%), Positives = 169/313 (53%), Gaps = 29/313 (9%)
Query: 557 KTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTN-----SV 611
K T R S D +D + K G + ++ + +K+ LSDLV+YT S
Sbjct: 305 KETHERKGSDKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKFKSF 364
Query: 612 AAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLP 671
+ N S ET+A ++ + + +F+ + +K +TRIYP A R DSSNFNP
Sbjct: 365 QHSRLYQQFNENN--SIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQE 422
Query: 672 YWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQ--QMCKGTFNPFS---GDPL 726
+WN GCQ+VALN+Q+ G M L KF NG GY+LKP + K FNP + G P+
Sbjct: 423 FWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNPSNIKEGMPI 482
Query: 727 PANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNG 786
L +++ISG QLP S ++G D V +E+ G+P D K QTRV+ N
Sbjct: 483 ------TLTIRLISGIQLPLTHSS--SNKG---DSLVIIEVFGVPNDQMKQQTRVIKKNA 531
Query: 787 FNPVWEETLTFTVHMPEIALVRFLVWDHDPI-GRDFVGQRTVTFSSLVPGYRHVYL---- 841
F+P W ET TF +H+PE+AL+RF+V I G +F+GQ T+ + GYR + L
Sbjct: 532 FSPRWNETFTFIIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRRIPLFSRM 591
Query: 842 -EGLTEASIFVHI 853
E L AS+FV++
Sbjct: 592 GESLEPASLFVYV 604
>gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens]
Length = 1291
Score = 239 bits (609), Expect = 1e-62
Identities = 165/502 (32%), Positives = 259/502 (51%), Gaps = 46/502 (9%)
Query: 13 EKVERCMSVMQSGTQMIKL--KRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIY 70
E + C S ++ GT M K+ + + F + ++ W + I I I
Sbjct: 21 EVLHLCRS-LEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIREIK 79
Query: 71 KVTEGRQSEIFHRQAEGNF---DPSCCFTIYHGNH--MESLDLITSNPEEARTWITGLKY 125
++ G+ S F R E D S CF I +G +++L L ++ +E WI GL +
Sbjct: 80 EIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTW 139
Query: 126 LMAGISDEDSL-AKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPR-RKV 183
LM ED+L A ++W+++ F D+N + ++ +++ ++ ++N +P R +
Sbjct: 140 LM-----EDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFL 194
Query: 184 RQMFQEADTDENQGTLTFEEFCVFYK--MMSLRRDLYLLLLSYSDKKD-------HLTVE 234
R+ D ++ G +T+ +F Y+ M S ++ + L L S + +++
Sbjct: 195 RERL--TDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLP 252
Query: 235 ELAQFLKVEQ---------KMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSP 285
E QFL Q ++ + D +++ E + ++ F F+ S
Sbjct: 253 EFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIE-------EPYFFLDEFVTFLFSK 305
Query: 286 ACDIFNPLHHEVYQD-MDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVE 344
++N V D M+ PL +Y+I+SSHNTYLTGDQ S+S ++ YAR L+ GCRC+E
Sbjct: 306 ENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIE 365
Query: 345 VDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKI 404
+DCWDGPDG PV++HG+TLT+KI F DV+ TI +HAFV +E+PVILSIE+HCSI QQR +
Sbjct: 366 LDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNM 425
Query: 405 AQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDS 464
AQY K + GD L V+ LPSP LK KIL+K KKL G EE S S
Sbjct: 426 AQYFKKVLGDTLLTKPVEI-SADGLPSPNQLKRKILIKHKKLAE--GSAYEEVPTSMMYS 482
Query: 465 ADEIEDECKFKLHYSNGTTEHQ 486
++I + K + Y H+
Sbjct: 483 ENDISNSIKNGILYLEDPVNHE 504
Score = 172 bits (435), Expect = 2e-42
Identities = 108/280 (38%), Positives = 155/280 (55%), Gaps = 20/280 (7%)
Query: 587 RLGRRRKTMKLCRELSDLVVYTNSVAAQDI---VDDGTTGNVLSFSETRAHQVVQQ-KSE 642
++ RRK K+ ELS+LVVY V + + ++ SF ET+A + V + K +
Sbjct: 941 KIMERRK--KIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGK 998
Query: 643 QFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANG 702
+F+ YN+ QL+RIYP R+DSSN++PLP W G QLVALN+Q+ + MQ+N+A F
Sbjct: 999 KFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGR 1058
Query: 703 NCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPF 762
+CGYVL+P M F+PF L + ++V+ + LPK RG I+ PF
Sbjct: 1059 HCGYVLQPSTMRDEAFDPFDKSSLRGLEPCAISIEVLGARHLPK------NGRG-IVCPF 1111
Query: 763 VEVEIIGLPVDCCKDQTRVVDDNGFNPVW-EETLTFTVHMPEIALVRFLVWDHDPIG-RD 820
VE+E+ G D K +T V DNG NPVW + F + PE A +RF+V++ D ++
Sbjct: 1112 VEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQN 1171
Query: 821 FVGQRTVTFSSLVPGYRHV-----YLEGLTEASIFVHITI 855
F+ Q T L GYR V Y E L AS+ + I I
Sbjct: 1172 FLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDI 1211
>gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens]
Length = 1290
Score = 239 bits (609), Expect = 1e-62
Identities = 165/502 (32%), Positives = 259/502 (51%), Gaps = 46/502 (9%)
Query: 13 EKVERCMSVMQSGTQMIKL--KRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIY 70
E + C S ++ GT M K+ + + F + ++ W + I I I
Sbjct: 21 EVLHLCRS-LEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIREIK 79
Query: 71 KVTEGRQSEIFHRQAEGNF---DPSCCFTIYHGNH--MESLDLITSNPEEARTWITGLKY 125
++ G+ S F R E D S CF I +G +++L L ++ +E WI GL +
Sbjct: 80 EIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTW 139
Query: 126 LMAGISDEDSL-AKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPR-RKV 183
LM ED+L A ++W+++ F D+N + ++ +++ ++ ++N +P R +
Sbjct: 140 LM-----EDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFL 194
Query: 184 RQMFQEADTDENQGTLTFEEFCVFYK--MMSLRRDLYLLLLSYSDKKD-------HLTVE 234
R+ D ++ G +T+ +F Y+ M S ++ + L L S + +++
Sbjct: 195 RERL--TDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLP 252
Query: 235 ELAQFLKVEQ---------KMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSP 285
E QFL Q ++ + D +++ E + ++ F F+ S
Sbjct: 253 EFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIE-------EPYFFLDEFVTFLFSK 305
Query: 286 ACDIFNPLHHEVYQD-MDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVE 344
++N V D M+ PL +Y+I+SSHNTYLTGDQ S+S ++ YAR L+ GCRC+E
Sbjct: 306 ENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIE 365
Query: 345 VDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKI 404
+DCWDGPDG PV++HG+TLT+KI F DV+ TI +HAFV +E+PVILSIE+HCSI QQR +
Sbjct: 366 LDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNM 425
Query: 405 AQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDS 464
AQY K + GD L V+ LPSP LK KIL+K KKL G EE S S
Sbjct: 426 AQYFKKVLGDTLLTKPVEI-SADGLPSPNQLKRKILIKHKKLAE--GSAYEEVPTSMMYS 482
Query: 465 ADEIEDECKFKLHYSNGTTEHQ 486
++I + K + Y H+
Sbjct: 483 ENDISNSIKNGILYLEDPVNHE 504
Score = 172 bits (435), Expect = 2e-42
Identities = 108/280 (38%), Positives = 155/280 (55%), Gaps = 20/280 (7%)
Query: 587 RLGRRRKTMKLCRELSDLVVYTNSVAAQDI---VDDGTTGNVLSFSETRAHQVVQQ-KSE 642
++ RRK K+ ELS+LVVY V + + ++ SF ET+A + V + K +
Sbjct: 941 KIMERRK--KIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGK 998
Query: 643 QFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANG 702
+F+ YN+ QL+RIYP R+DSSN++PLP W G QLVALN+Q+ + MQ+N+A F
Sbjct: 999 KFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGR 1058
Query: 703 NCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPF 762
+CGYVL+P M F+PF L + ++V+ + LPK RG I+ PF
Sbjct: 1059 HCGYVLQPSTMRDEAFDPFDKSSLRGLEPCAISIEVLGARHLPK------NGRG-IVCPF 1111
Query: 763 VEVEIIGLPVDCCKDQTRVVDDNGFNPVW-EETLTFTVHMPEIALVRFLVWDHDPIG-RD 820
VE+E+ G D K +T V DNG NPVW + F + PE A +RF+V++ D ++
Sbjct: 1112 VEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQN 1171
Query: 821 FVGQRTVTFSSLVPGYRHV-----YLEGLTEASIFVHITI 855
F+ Q T L GYR V Y E L AS+ + I I
Sbjct: 1172 FLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDI 1211
>gi|117320537 phospholipase C, gamma 2 [Homo sapiens]
Length = 1265
Score = 235 bits (599), Expect = 2e-61
Identities = 150/443 (33%), Positives = 233/443 (52%), Gaps = 54/443 (12%)
Query: 56 SRKSEKAKILID--SIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNH--MESLDLITS 111
S+ ++K + +D I ++ G+ S+ F R CCFTI +G + +L L
Sbjct: 55 SKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAAD 114
Query: 112 NPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLM 171
+ E+A W++GLK L E A + W+++ D+ +++ E+ ++
Sbjct: 115 SKEDAVNWLSGLKIL----HQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTIL 170
Query: 172 HKLNVNLPRRK-VRQMFQEADTDENQGTLTFEEFCVFYKMM----------SLRRDLYLL 220
+N + K ++ F E +++ L+FE+F +FYK + ++D +
Sbjct: 171 PLINFKVSSAKFLKDKFVEIGAHKDE--LSFEQFHLFYKKLMFEQQKSILDEFKKDSSVF 228
Query: 221 LLSYSDKKD--------------HLTVEELAQFL-KVEQKMNNVTTDYCLDIIKKFEVSE 265
+L +D+ D H E AQ L KV ++M D + + F
Sbjct: 229 ILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPF---- 284
Query: 266 ENKVKNVLGIEGFTNFMRSPACDIFNPLHHEV-YQDMDQPLCNYYIASSHNTYLTGDQLL 324
L ++ F ++ S I++ + V QDM+ PL +Y+I+SSHNTYLTGDQL
Sbjct: 285 -------LFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLR 337
Query: 325 SQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKN 384
S+S + Y R L+ GCRC+E+DCWDGPDG+PV++HG+T T+KI F DVV+ I HAFV +
Sbjct: 338 SESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTS 397
Query: 385 EFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKILVKGK 444
FPVILSIE HCS++QQR +A+ K +FGD L L+ QLPSP L+ KI++K K
Sbjct: 398 SFPVILSIEEHCSVEQQRHMAKAFKEVFGDLL-LTKPTEASADQLPSPSQLREKIIIKHK 456
Query: 445 KLPYHLGDDAEEGEVSDEDSADE 467
KL + +V+ ED DE
Sbjct: 457 KL-----GPRGDVDVNMEDKKDE 474
Score = 169 bits (427), Expect = 2e-41
Identities = 100/273 (36%), Positives = 153/273 (56%), Gaps = 26/273 (9%)
Query: 593 KTMKLCRELSDLVVYTNSVA-AQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQ 651
K + ELSDLVVY + +D +++ + SF ET+A +++QK + YNQK
Sbjct: 922 KNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKG 981
Query: 652 LTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQ 711
LTR+YP R+DSSN++P W G Q+VALN+Q+ + MQ+N A F NG GYVL+P+
Sbjct: 982 LTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPE 1041
Query: 712 QMCKGTFNPFSGDPLPANPKKQLIL----KVISGQQLPKPPDSMFGDRGEIIDPFVEVEI 767
M + DP+P ++++++ KV+ + LPK S I PFVEVEI
Sbjct: 1042 SMRTEKY-----DPMPPESQRKILMTLTVKVLGARHLPKLGRS-------IACPFVEVEI 1089
Query: 768 IGLPVDCCKDQTRVVDDNGFNPVW---EETLTFTVHMPEIALVRFLVWDHDPIG-RDFVG 823
G D K +T VV+DNG +P+W +E +TF ++ P +A +RF+V++ D +F+
Sbjct: 1090 CGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLA 1149
Query: 824 QRTVTFSSLVPGYRHV-----YLEGLTEASIFV 851
T ++ G+R V Y E + AS+ V
Sbjct: 1150 HATYPIKAVKSGFRSVPLKNGYSEDIELASLLV 1182
>gi|12083581 phosphoinositide-specific phospholipase C beta 1
isoform a [Homo sapiens]
Length = 1216
Score = 174 bits (441), Expect = 4e-43
Identities = 119/411 (28%), Positives = 212/411 (51%), Gaps = 35/411 (8%)
Query: 102 HMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEA--DKNGD 159
++ L+L+ E A+ W + L +L + + D ++++ + + +
Sbjct: 113 NISHLNLVAFQEEVAKEWTNEVFSLAT------NLLAQNMSRDAFLEKAYTKLKLQVTPE 166
Query: 160 GLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDEN------QGTLTFEEFCVFYKMMSL 213
G + ++ I++L + R++V + + Q T E + VF +
Sbjct: 167 GRIPLKNIYRLF-----SADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCP 221
Query: 214 RRDLYLLLLSYSDK-KDHLTVEELAQFLKVEQK---MNNVT-----TDYCLDIIKKFEVS 264
R ++ + + K K +LTV+++ F+ ++Q+ +N + + +I+K+E +
Sbjct: 222 RPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPN 281
Query: 265 EENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLL 324
K + ++GF ++ + +P ++ +DM QPL +Y+I SSHNTYLT QL
Sbjct: 282 NSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLA 341
Query: 325 SQSKVDMYARVLQEGCRCVEVDCWDG--PDGEPVVHHGYTLTSKILFRDVVETINKHAFV 382
S V+MY +VL GCRCVE+DCW G + EPV+ HG+T+T++I F++V+E I + AF
Sbjct: 342 GNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFK 401
Query: 383 KNEFPVILSIENHC-SIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQ---LPSPQSLKGK 438
+ FP++LS ENH S +QQ K+A+Y + IFGD L + ++ + LPSP L K
Sbjct: 402 TSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYK 461
Query: 439 ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVES 489
ILVK KK + + + + ++S++ S + F+ S G E ES
Sbjct: 462 ILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFE-PSSPGAGEADTES 511
Score = 145 bits (366), Expect = 2e-34
Identities = 99/309 (32%), Positives = 161/309 (52%), Gaps = 34/309 (11%)
Query: 563 SKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDD--- 619
++S DD++D ++S+ EG E+S+LV Y V +
Sbjct: 509 TESDDDDDDDDCKKSSMDEG-------TAGSEAMATEEMSNLVNYIQPVKFESFEISKKR 561
Query: 620 GTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQL 679
+ + SF ET+ + + + +F+ YN+ QL+RIYP R+DSSN+ P +WNAGCQ+
Sbjct: 562 NKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQM 621
Query: 680 VALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT--FNPFSGDPLPANPKKQLILK 737
VALN+Q+ MQ+N ++ NG GY LKP+ M + F+PF+ + L +K
Sbjct: 622 VALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVK 681
Query: 738 VISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKD--QTRVVDDNGFNPVW-EET 794
+ISGQ L + + +VEV++ GLPVD + +T+ N NPVW EE
Sbjct: 682 IISGQFL----------SDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEP 731
Query: 795 LTF-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYL-----EGLTEAS 848
+ F V +P +A +R V++ G F+G R + ++ PGY ++ L + LT +
Sbjct: 732 IVFKKVVLPTLACLRIAVYEE---GGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPA 788
Query: 849 IFVHITINE 857
+FV+I + +
Sbjct: 789 VFVYIEVKD 797
>gi|33356544 phosphoinositide-specific phospholipase C beta 1
isoform b [Homo sapiens]
Length = 1173
Score = 174 bits (441), Expect = 4e-43
Identities = 119/411 (28%), Positives = 212/411 (51%), Gaps = 35/411 (8%)
Query: 102 HMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEA--DKNGD 159
++ L+L+ E A+ W + L +L + + D ++++ + + +
Sbjct: 113 NISHLNLVAFQEEVAKEWTNEVFSLAT------NLLAQNMSRDAFLEKAYTKLKLQVTPE 166
Query: 160 GLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDEN------QGTLTFEEFCVFYKMMSL 213
G + ++ I++L + R++V + + Q T E + VF +
Sbjct: 167 GRIPLKNIYRLF-----SADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCP 221
Query: 214 RRDLYLLLLSYSDK-KDHLTVEELAQFLKVEQK---MNNVT-----TDYCLDIIKKFEVS 264
R ++ + + K K +LTV+++ F+ ++Q+ +N + + +I+K+E +
Sbjct: 222 RPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPN 281
Query: 265 EENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLL 324
K + ++GF ++ + +P ++ +DM QPL +Y+I SSHNTYLT QL
Sbjct: 282 NSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLA 341
Query: 325 SQSKVDMYARVLQEGCRCVEVDCWDG--PDGEPVVHHGYTLTSKILFRDVVETINKHAFV 382
S V+MY +VL GCRCVE+DCW G + EPV+ HG+T+T++I F++V+E I + AF
Sbjct: 342 GNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFK 401
Query: 383 KNEFPVILSIENHC-SIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQ---LPSPQSLKGK 438
+ FP++LS ENH S +QQ K+A+Y + IFGD L + ++ + LPSP L K
Sbjct: 402 TSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYK 461
Query: 439 ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVES 489
ILVK KK + + + + ++S++ S + F+ S G E ES
Sbjct: 462 ILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFE-PSSPGAGEADTES 511
Score = 145 bits (366), Expect = 2e-34
Identities = 99/309 (32%), Positives = 161/309 (52%), Gaps = 34/309 (11%)
Query: 563 SKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDD--- 619
++S DD++D ++S+ EG E+S+LV Y V +
Sbjct: 509 TESDDDDDDDDCKKSSMDEG-------TAGSEAMATEEMSNLVNYIQPVKFESFEISKKR 561
Query: 620 GTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQL 679
+ + SF ET+ + + + +F+ YN+ QL+RIYP R+DSSN+ P +WNAGCQ+
Sbjct: 562 NKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQM 621
Query: 680 VALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT--FNPFSGDPLPANPKKQLILK 737
VALN+Q+ MQ+N ++ NG GY LKP+ M + F+PF+ + L +K
Sbjct: 622 VALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVK 681
Query: 738 VISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKD--QTRVVDDNGFNPVW-EET 794
+ISGQ L + + +VEV++ GLPVD + +T+ N NPVW EE
Sbjct: 682 IISGQFL----------SDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEP 731
Query: 795 LTF-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYL-----EGLTEAS 848
+ F V +P +A +R V++ G F+G R + ++ PGY ++ L + LT +
Sbjct: 732 IVFKKVVLPTLACLRIAVYEE---GGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPA 788
Query: 849 IFVHITINE 857
+FV+I + +
Sbjct: 789 VFVYIEVKD 797
>gi|95147333 phospholipase C, beta 2 [Homo sapiens]
Length = 1185
Score = 169 bits (428), Expect = 1e-41
Identities = 100/253 (39%), Positives = 146/253 (57%), Gaps = 17/253 (6%)
Query: 210 MMSL--RRDLYLLLLSYSDK-KDHLTVEELAQFLKVEQKMNNVTT--------DYCLDII 258
+MSL R ++ + SY K K ++T E L +F+ +Q+ + + + D +I
Sbjct: 212 LMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGLI 271
Query: 259 KKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYL 318
K+E S N + L EG F+ P + ++ DM QPL +Y+I SSHNTYL
Sbjct: 272 DKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYL 331
Query: 319 TGDQLLSQSKVDMYARVLQEGCRCVEVDCWDG--PDGEPVVHHGYTLTSKILFRDVVETI 376
T Q S +MY +VL GCRCVE+DCW G PD EP++ HG+T+T+ I F++ +E I
Sbjct: 332 TAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAI 391
Query: 377 NKHAFVKNEFPVILSIENHC-SIQQQRKIAQYLKGIFGDKLDLSSVDTGECK---QLPSP 432
+ AF + +P+ILS ENH S +QQ K+A+Y + IFGD L ++ K LPSP
Sbjct: 392 AESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSP 451
Query: 433 QSLKGKILVKGKK 445
+ L+GKIL+K KK
Sbjct: 452 EDLRGKILIKNKK 464
Score = 152 bits (383), Expect = 2e-36
Identities = 125/413 (30%), Positives = 204/413 (49%), Gaps = 39/413 (9%)
Query: 570 DEEDTQQSTGKEGGQLYRLGRRRKTMKL----CRELSDLVVY---TNSVAAQDIVDDGTT 622
+EE+ ++S + ++ ++ T L E+S LV Y T V+ + +
Sbjct: 511 EEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRS 570
Query: 623 GNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVAL 682
+ SF+E +A+ ++ + S QF+ YN++Q++RIYP R+DSSN+ P +WNAGCQ+VAL
Sbjct: 571 YVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVAL 630
Query: 683 NYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCK--GTFNPFSGDPLPANPKKQLILKVIS 740
N+Q+ MQ N A F+ NG GY+LK + M + FNPFS D + L + VIS
Sbjct: 631 NFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVIS 690
Query: 741 GQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKD-QTRV-VDDNGFNPVW-EETLTF 797
GQ L + + +VEVE+ GLP D + +T++ N NPVW EE F
Sbjct: 691 GQFLSE----------RSVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVF 740
Query: 798 -TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEG-----LTEASIFV 851
+ MPE+A +R V + G F+G R + ++L GY H+ L LT ++F+
Sbjct: 741 EKILMPELASLRVAVMEE---GNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFI 797
Query: 852 HITINE-IYGKWSPLILNPSYTILHFLG-ATKNRQLQGLKGLFNKNPRHSSSENNSHYVR 909
+ + + I G W+ L + + I F TK+ +L+ G + P +S S
Sbjct: 798 FLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGGLPEKPFPLASPVAS---- 853
Query: 910 KRSIGDRILRRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRTTR 962
+ + + +PA + +E E + + E R+ GV++ R
Sbjct: 854 --QVNGALAPTSNGSPAARAGAREEAMKEAAEPRTASLEELRELKGVVKLQRR 904
>gi|209862851 plastin 3 [Homo sapiens]
Length = 630
Score = 45.1 bits (105), Expect = 3e-04
Identities = 26/81 (32%), Positives = 47/81 (58%), Gaps = 5/81 (6%)
Query: 134 DSLAKRQRTHDQW--VKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQE-- 189
D +A Q + D+ +K+ F + D N +G + E+H+L + N+ LP KVR++ Q+
Sbjct: 2 DEMATTQISKDELDELKEAFAKVDLNSNGFICDYELHELFKEANMPLPGYKVREIIQKLM 61
Query: 190 ADTDENQ-GTLTFEEFCVFYK 209
D D N+ G ++F+EF ++
Sbjct: 62 LDGDRNKDGKISFDEFVYIFQ 82
>gi|7549809 plastin 3 [Homo sapiens]
Length = 630
Score = 45.1 bits (105), Expect = 3e-04
Identities = 26/81 (32%), Positives = 47/81 (58%), Gaps = 5/81 (6%)
Query: 134 DSLAKRQRTHDQW--VKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQE-- 189
D +A Q + D+ +K+ F + D N +G + E+H+L + N+ LP KVR++ Q+
Sbjct: 2 DEMATTQISKDELDELKEAFAKVDLNSNGFICDYELHELFKEANMPLPGYKVREIIQKLM 61
Query: 190 ADTDENQ-GTLTFEEFCVFYK 209
D D N+ G ++F+EF ++
Sbjct: 62 LDGDRNKDGKISFDEFVYIFQ 82
>gi|11067753 calcium binding protein 5 [Homo sapiens]
Length = 173
Score = 44.7 bits (104), Expect = 4e-04
Identities = 27/69 (39%), Positives = 41/69 (59%), Gaps = 5/69 (7%)
Query: 145 QWVKQTFEEADKNGDGLLNIEEIHQLMHK-LNVNLPRRKVRQMFQEADTDENQGTLTFEE 203
Q ++ F+E D NGDG + + E+ Q M + L L R++ ++ +EAD + GT+ FEE
Sbjct: 108 QEMRDAFKEFDTNGDGEITLVELQQAMQRLLGERLTPREISEVVREADVN-GDGTVDFEE 166
Query: 204 FCVFYKMMS 212
F KMMS
Sbjct: 167 ---FVKMMS 172
>gi|223278387 calmodulin-like 5 [Homo sapiens]
Length = 146
Score = 44.3 bits (103), Expect = 6e-04
Identities = 26/91 (28%), Positives = 46/91 (50%), Gaps = 3/91 (3%)
Query: 148 KQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEFCVF 207
K+ F D +G+G +N +E+ + NL ++R++ E D+D G ++F+EF
Sbjct: 14 KKAFSAVDTDGNGTINAQELGAALKATGKNLSEAQLRKLISEVDSD-GDGEISFQEFLTA 72
Query: 208 YKMMSL-RRDLYLLLLSYSDKKD-HLTVEEL 236
K DL + ++ D H+TV+EL
Sbjct: 73 AKKARAGLEDLQVAFRAFDQDGDGHITVDEL 103
Score = 43.9 bits (102), Expect = 8e-04
Identities = 22/68 (32%), Positives = 41/68 (60%), Gaps = 1/68 (1%)
Query: 137 AKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQ 196
AK+ R + ++ F D++GDG + ++E+ + M L LP+ ++ M +EAD D++
Sbjct: 73 AKKARAGLEDLQVAFRAFDQDGDGHITVDELRRAMAGLGQPLPQEELDAMIREADVDQD- 131
Query: 197 GTLTFEEF 204
G + +EEF
Sbjct: 132 GRVNYEEF 139
>gi|4885111 calmodulin-like 3 [Homo sapiens]
Length = 149
Score = 43.5 bits (101), Expect = 0.001
Identities = 39/148 (26%), Positives = 71/148 (47%), Gaps = 28/148 (18%)
Query: 71 KVTEGRQS-EIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAG 129
+VTE +++ +F + +G C T G M SL NP EA L+ +M+
Sbjct: 9 QVTEFKEAFSLFDKDGDG-----CITTRELGTVMRSLG---QNPTEAE-----LRDMMSE 55
Query: 130 ISDEDS-----------LAKRQRTHD--QWVKQTFEEADKNGDGLLNIEEIHQLMHKLNV 176
I + + +A++ + D + +++ F DK+G+G ++ E+ +M +L
Sbjct: 56 IDRDGNGTVDFPEFLGMMARKMKDTDNEEEIREAFRVFDKDGNGFVSAAELRHVMTRLGE 115
Query: 177 NLPRRKVRQMFQEADTDENQGTLTFEEF 204
L +V +M + ADTD G + +EEF
Sbjct: 116 KLSDEEVDEMIRAADTD-GDGQVNYEEF 142
>gi|58218968 calmodulin 3 [Homo sapiens]
Length = 149
Score = 42.0 bits (97), Expect = 0.003
Identities = 21/57 (36%), Positives = 31/57 (54%), Gaps = 1/57 (1%)
Query: 148 KQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEF 204
K+ F DK+GDG + +E+ +M L N +++ M E D D N GT+ F EF
Sbjct: 14 KEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGN-GTIDFPEF 69
Score = 40.4 bits (93), Expect = 0.008
Identities = 19/61 (31%), Positives = 35/61 (57%), Gaps = 1/61 (1%)
Query: 144 DQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEE 203
++ +++ F DK+G+G ++ E+ +M L L +V +M +EAD D G + +EE
Sbjct: 83 EEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADID-GDGQVNYEE 141
Query: 204 F 204
F
Sbjct: 142 F 142
>gi|4502549 calmodulin 2 [Homo sapiens]
Length = 149
Score = 42.0 bits (97), Expect = 0.003
Identities = 21/57 (36%), Positives = 31/57 (54%), Gaps = 1/57 (1%)
Query: 148 KQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEF 204
K+ F DK+GDG + +E+ +M L N +++ M E D D N GT+ F EF
Sbjct: 14 KEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGN-GTIDFPEF 69
Score = 40.4 bits (93), Expect = 0.008
Identities = 19/61 (31%), Positives = 35/61 (57%), Gaps = 1/61 (1%)
Query: 144 DQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEE 203
++ +++ F DK+G+G ++ E+ +M L L +V +M +EAD D G + +EE
Sbjct: 83 EEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADID-GDGQVNYEE 141
Query: 204 F 204
F
Sbjct: 142 F 142
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.134 0.393
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,549,500
Number of Sequences: 37866
Number of extensions: 1733516
Number of successful extensions: 5909
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 57
Number of HSP's successfully gapped in prelim test: 144
Number of HSP's that attempted gapping in prelim test: 5552
Number of HSP's gapped (non-prelim): 393
length of query: 1002
length of database: 18,247,518
effective HSP length: 112
effective length of query: 890
effective length of database: 14,006,526
effective search space: 12465808140
effective search space used: 12465808140
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.