BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens] (1693 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens] 3412 0.0 gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens] 3322 0.0 gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens] 2025 0.0 gi|78499633 phospholipase C, eta 2 [Homo sapiens] 1211 0.0 gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens] 344 5e-94 gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens] 344 5e-94 gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens] 339 2e-92 gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens] 339 2e-92 gi|14249340 phospholipase C, delta 4 [Homo sapiens] 337 8e-92 gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens] 330 9e-90 gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens] 330 9e-90 gi|117168250 phospholipase C, epsilon 1 [Homo sapiens] 307 5e-83 gi|19115964 phospholipase C delta 3 [Homo sapiens] 295 3e-79 gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens] 293 1e-78 gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens] 293 1e-78 gi|11386139 phospholipase C beta 3 [Homo sapiens] 285 2e-76 gi|25188201 phospholipase C, zeta 1 [Homo sapiens] 244 5e-64 gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] 239 2e-62 gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] 239 2e-62 gi|117320537 phospholipase C, gamma 2 [Homo sapiens] 235 3e-61 gi|12083581 phosphoinositide-specific phospholipase C beta 1 iso... 174 7e-43 gi|33356544 phosphoinositide-specific phospholipase C beta 1 iso... 174 7e-43 gi|95147333 phospholipase C, beta 2 [Homo sapiens] 169 2e-41 gi|209862851 plastin 3 [Homo sapiens] 45 6e-04 gi|7549809 plastin 3 [Homo sapiens] 45 6e-04 gi|11067753 calcium binding protein 5 [Homo sapiens] 45 8e-04 gi|223278387 calmodulin-like 5 [Homo sapiens] 44 0.001 gi|4885111 calmodulin-like 3 [Homo sapiens] 44 0.002 gi|58218968 calmodulin 3 [Homo sapiens] 42 0.005 gi|4502549 calmodulin 2 [Homo sapiens] 42 0.005 >gi|195972871 phospholipase C eta 1 isoform a [Homo sapiens] Length = 1693 Score = 3412 bits (8848), Expect = 0.0 Identities = 1693/1693 (100%), Positives = 1693/1693 (100%) Query: 1 MADLEVYKNLSPEKVERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSE 60 MADLEVYKNLSPEKVERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSE Sbjct: 1 MADLEVYKNLSPEKVERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSE 60 Query: 61 KAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWI 120 KAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWI Sbjct: 61 KAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWI 120 Query: 121 TGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPR 180 TGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPR Sbjct: 121 TGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPR 180 Query: 181 RKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFL 240 RKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFL Sbjct: 181 RKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFL 240 Query: 241 KVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQD 300 KVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQD Sbjct: 241 KVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQD 300 Query: 301 MDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHG 360 MDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHG Sbjct: 301 MDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHG 360 Query: 361 YTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSS 420 YTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSS Sbjct: 361 YTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSS 420 Query: 421 VDTGECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSN 480 VDTGECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSN Sbjct: 421 VDTGECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSN 480 Query: 481 GTTEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESG 540 GTTEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESG Sbjct: 481 GTTEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESG 540 Query: 541 KKSHGRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRE 600 KKSHGRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRE Sbjct: 541 KKSHGRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRE 600 Query: 601 LSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY 660 LSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY Sbjct: 601 LSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY 660 Query: 661 RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNP 720 RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNP Sbjct: 661 RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNP 720 Query: 721 FSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTR 780 FSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTR Sbjct: 721 FSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTR 780 Query: 781 VVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVY 840 VVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVY Sbjct: 781 VVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVY 840 Query: 841 LEGLTEASIFVHITINEIYGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHSS 900 LEGLTEASIFVHITINEIYGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHSS Sbjct: 841 LEGLTEASIFVHITINEIYGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHSS 900 Query: 901 SENNSHYVRKRSIGDRILRRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRT 960 SENNSHYVRKRSIGDRILRRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRT Sbjct: 901 SENNSHYVRKRSIGDRILRRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRT 960 Query: 961 TRSLQARPVSMPVDRNLLGALSLPVSETAKDIEGKENSLAEDKDGRRKGKASIKDPHFLN 1020 TRSLQARPVSMPVDRNLLGALSLPVSETAKDIEGKENSLAEDKDGRRKGKASIKDPHFLN Sbjct: 961 TRSLQARPVSMPVDRNLLGALSLPVSETAKDIEGKENSLAEDKDGRRKGKASIKDPHFLN 1020 Query: 1021 FNKKLSSSSSALLHKDTSQGDTIVSTAHMSVTGEQLGMSSPRGGRTTSNATSNCQENPCP 1080 FNKKLSSSSSALLHKDTSQGDTIVSTAHMSVTGEQLGMSSPRGGRTTSNATSNCQENPCP Sbjct: 1021 FNKKLSSSSSALLHKDTSQGDTIVSTAHMSVTGEQLGMSSPRGGRTTSNATSNCQENPCP 1080 Query: 1081 SKSLSPKQHLAPDPVVNPTQDLHGVKIKEKGNPEDFVEGKSILSGSVLSHSNLEIKNLEG 1140 SKSLSPKQHLAPDPVVNPTQDLHGVKIKEKGNPEDFVEGKSILSGSVLSHSNLEIKNLEG Sbjct: 1081 SKSLSPKQHLAPDPVVNPTQDLHGVKIKEKGNPEDFVEGKSILSGSVLSHSNLEIKNLEG 1140 Query: 1141 NRGKGRAATSFSLSDVSMLCSDIPDLHSTAILQESVISHLIDNVTLTNENEPGSSISALI 1200 NRGKGRAATSFSLSDVSMLCSDIPDLHSTAILQESVISHLIDNVTLTNENEPGSSISALI Sbjct: 1141 NRGKGRAATSFSLSDVSMLCSDIPDLHSTAILQESVISHLIDNVTLTNENEPGSSISALI 1200 Query: 1201 GQFDETNNQALTVVSHLHNTSVMSGHCPLPSLGLKMPIKHGFCKGKSKSSFLCSSPELIA 1260 GQFDETNNQALTVVSHLHNTSVMSGHCPLPSLGLKMPIKHGFCKGKSKSSFLCSSPELIA Sbjct: 1201 GQFDETNNQALTVVSHLHNTSVMSGHCPLPSLGLKMPIKHGFCKGKSKSSFLCSSPELIA 1260 Query: 1261 LSSSETTKHATNTVYETTCTPISKTKPDDDLSSKAKTAALESNLPGSPNTSRGWLPKSPT 1320 LSSSETTKHATNTVYETTCTPISKTKPDDDLSSKAKTAALESNLPGSPNTSRGWLPKSPT Sbjct: 1261 LSSSETTKHATNTVYETTCTPISKTKPDDDLSSKAKTAALESNLPGSPNTSRGWLPKSPT 1320 Query: 1321 KGEDWETLKSCSPASSPDLTLEDVIADPTLCFNSGESSLVEIDGESENLSLTTCEYRREG 1380 KGEDWETLKSCSPASSPDLTLEDVIADPTLCFNSGESSLVEIDGESENLSLTTCEYRREG Sbjct: 1321 KGEDWETLKSCSPASSPDLTLEDVIADPTLCFNSGESSLVEIDGESENLSLTTCEYRREG 1380 Query: 1381 TSQLASPLKLKYNQGVVEHFQRGLRNGYCKETLRPSVPEIFNNIQDVKTQSISYLAYQGA 1440 TSQLASPLKLKYNQGVVEHFQRGLRNGYCKETLRPSVPEIFNNIQDVKTQSISYLAYQGA Sbjct: 1381 TSQLASPLKLKYNQGVVEHFQRGLRNGYCKETLRPSVPEIFNNIQDVKTQSISYLAYQGA 1440 Query: 1441 GFVHNHFSDSDAKMFQTCVPQQSSAQDMHVPVPKQLAHLPLPALKLPSPCKSKSLGDLTS 1500 GFVHNHFSDSDAKMFQTCVPQQSSAQDMHVPVPKQLAHLPLPALKLPSPCKSKSLGDLTS Sbjct: 1441 GFVHNHFSDSDAKMFQTCVPQQSSAQDMHVPVPKQLAHLPLPALKLPSPCKSKSLGDLTS 1500 Query: 1501 EDIACNFESKYQCISKSFVTTGIRDKKGVTVKTKSLEPIDALTEQLRKLVSFDQEDNCQV 1560 EDIACNFESKYQCISKSFVTTGIRDKKGVTVKTKSLEPIDALTEQLRKLVSFDQEDNCQV Sbjct: 1501 EDIACNFESKYQCISKSFVTTGIRDKKGVTVKTKSLEPIDALTEQLRKLVSFDQEDNCQV 1560 Query: 1561 LYSKQDANQLPRALVRKLSSRSQSRVRNIASRAKEKQEANKQKVPNPSNGAGVVLRNKPS 1620 LYSKQDANQLPRALVRKLSSRSQSRVRNIASRAKEKQEANKQKVPNPSNGAGVVLRNKPS Sbjct: 1561 LYSKQDANQLPRALVRKLSSRSQSRVRNIASRAKEKQEANKQKVPNPSNGAGVVLRNKPS 1620 Query: 1621 APTPAVNRHSTGSYIAGYLKNTKGGGLEGRGIPEGACTALHYGHVDQFCSDNSVLQTEPS 1680 APTPAVNRHSTGSYIAGYLKNTKGGGLEGRGIPEGACTALHYGHVDQFCSDNSVLQTEPS Sbjct: 1621 APTPAVNRHSTGSYIAGYLKNTKGGGLEGRGIPEGACTALHYGHVDQFCSDNSVLQTEPS 1680 Query: 1681 SDDKPEIYFLLRL 1693 SDDKPEIYFLLRL Sbjct: 1681 SDDKPEIYFLLRL 1693 >gi|57863298 phospholipase C eta 1 isoform b [Homo sapiens] Length = 1655 Score = 3322 bits (8614), Expect = 0.0 Identities = 1655/1675 (98%), Positives = 1655/1675 (98%), Gaps = 20/1675 (1%) Query: 19 MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQS 78 MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQS Sbjct: 1 MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQS 60 Query: 79 EIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAK 138 EIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAK Sbjct: 61 EIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAK 120 Query: 139 RQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGT 198 RQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGT Sbjct: 121 RQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGT 180 Query: 199 LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDII 258 LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDII Sbjct: 181 LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDII 240 Query: 259 KKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYL 318 KKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYL Sbjct: 241 KKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYL 300 Query: 319 TGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINK 378 TGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINK Sbjct: 301 TGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINK 360 Query: 379 HAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGK 438 HAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGK Sbjct: 361 HAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGK 420 Query: 439 ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESL 498 ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESL Sbjct: 421 ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESL 480 Query: 499 LKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSHGRSLMTNFGKHKKT 558 LKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSHGRSLMTNFGKHKKT Sbjct: 481 LKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSHGRSLMTNFGKHKKT 540 Query: 559 TKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVD 618 TKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVD Sbjct: 541 TKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVD 600 Query: 619 DGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQ 678 DGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQ Sbjct: 601 DGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQ 660 Query: 679 LVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKV 738 LVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKV Sbjct: 661 LVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKV 720 Query: 739 ISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFT 798 ISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFT Sbjct: 721 ISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFT 780 Query: 799 VHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEI 858 VHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEI Sbjct: 781 VHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFVHITINEI 840 Query: 859 YGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHSSSENNSHYVRKRSIGDRIL 918 YG KNRQLQGLKGLFNKNPRHSSSENNSHYVRKRSIGDRIL Sbjct: 841 YG--------------------KNRQLQGLKGLFNKNPRHSSSENNSHYVRKRSIGDRIL 880 Query: 919 RRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRTTRSLQARPVSMPVDRNLL 978 RRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRTTRSLQARPVSMPVDRNLL Sbjct: 881 RRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRTTRSLQARPVSMPVDRNLL 940 Query: 979 GALSLPVSETAKDIEGKENSLAEDKDGRRKGKASIKDPHFLNFNKKLSSSSSALLHKDTS 1038 GALSLPVSETAKDIEGKENSLAEDKDGRRKGKASIKDPHFLNFNKKLSSSSSALLHKDTS Sbjct: 941 GALSLPVSETAKDIEGKENSLAEDKDGRRKGKASIKDPHFLNFNKKLSSSSSALLHKDTS 1000 Query: 1039 QGDTIVSTAHMSVTGEQLGMSSPRGGRTTSNATSNCQENPCPSKSLSPKQHLAPDPVVNP 1098 QGDTIVSTAHMSVTGEQLGMSSPRGGRTTSNATSNCQENPCPSKSLSPKQHLAPDPVVNP Sbjct: 1001 QGDTIVSTAHMSVTGEQLGMSSPRGGRTTSNATSNCQENPCPSKSLSPKQHLAPDPVVNP 1060 Query: 1099 TQDLHGVKIKEKGNPEDFVEGKSILSGSVLSHSNLEIKNLEGNRGKGRAATSFSLSDVSM 1158 TQDLHGVKIKEKGNPEDFVEGKSILSGSVLSHSNLEIKNLEGNRGKGRAATSFSLSDVSM Sbjct: 1061 TQDLHGVKIKEKGNPEDFVEGKSILSGSVLSHSNLEIKNLEGNRGKGRAATSFSLSDVSM 1120 Query: 1159 LCSDIPDLHSTAILQESVISHLIDNVTLTNENEPGSSISALIGQFDETNNQALTVVSHLH 1218 LCSDIPDLHSTAILQESVISHLIDNVTLTNENEPGSSISALIGQFDETNNQALTVVSHLH Sbjct: 1121 LCSDIPDLHSTAILQESVISHLIDNVTLTNENEPGSSISALIGQFDETNNQALTVVSHLH 1180 Query: 1219 NTSVMSGHCPLPSLGLKMPIKHGFCKGKSKSSFLCSSPELIALSSSETTKHATNTVYETT 1278 NTSVMSGHCPLPSLGLKMPIKHGFCKGKSKSSFLCSSPELIALSSSETTKHATNTVYETT Sbjct: 1181 NTSVMSGHCPLPSLGLKMPIKHGFCKGKSKSSFLCSSPELIALSSSETTKHATNTVYETT 1240 Query: 1279 CTPISKTKPDDDLSSKAKTAALESNLPGSPNTSRGWLPKSPTKGEDWETLKSCSPASSPD 1338 CTPISKTKPDDDLSSKAKTAALESNLPGSPNTSRGWLPKSPTKGEDWETLKSCSPASSPD Sbjct: 1241 CTPISKTKPDDDLSSKAKTAALESNLPGSPNTSRGWLPKSPTKGEDWETLKSCSPASSPD 1300 Query: 1339 LTLEDVIADPTLCFNSGESSLVEIDGESENLSLTTCEYRREGTSQLASPLKLKYNQGVVE 1398 LTLEDVIADPTLCFNSGESSLVEIDGESENLSLTTCEYRREGTSQLASPLKLKYNQGVVE Sbjct: 1301 LTLEDVIADPTLCFNSGESSLVEIDGESENLSLTTCEYRREGTSQLASPLKLKYNQGVVE 1360 Query: 1399 HFQRGLRNGYCKETLRPSVPEIFNNIQDVKTQSISYLAYQGAGFVHNHFSDSDAKMFQTC 1458 HFQRGLRNGYCKETLRPSVPEIFNNIQDVKTQSISYLAYQGAGFVHNHFSDSDAKMFQTC Sbjct: 1361 HFQRGLRNGYCKETLRPSVPEIFNNIQDVKTQSISYLAYQGAGFVHNHFSDSDAKMFQTC 1420 Query: 1459 VPQQSSAQDMHVPVPKQLAHLPLPALKLPSPCKSKSLGDLTSEDIACNFESKYQCISKSF 1518 VPQQSSAQDMHVPVPKQLAHLPLPALKLPSPCKSKSLGDLTSEDIACNFESKYQCISKSF Sbjct: 1421 VPQQSSAQDMHVPVPKQLAHLPLPALKLPSPCKSKSLGDLTSEDIACNFESKYQCISKSF 1480 Query: 1519 VTTGIRDKKGVTVKTKSLEPIDALTEQLRKLVSFDQEDNCQVLYSKQDANQLPRALVRKL 1578 VTTGIRDKKGVTVKTKSLEPIDALTEQLRKLVSFDQEDNCQVLYSKQDANQLPRALVRKL Sbjct: 1481 VTTGIRDKKGVTVKTKSLEPIDALTEQLRKLVSFDQEDNCQVLYSKQDANQLPRALVRKL 1540 Query: 1579 SSRSQSRVRNIASRAKEKQEANKQKVPNPSNGAGVVLRNKPSAPTPAVNRHSTGSYIAGY 1638 SSRSQSRVRNIASRAKEKQEANKQKVPNPSNGAGVVLRNKPSAPTPAVNRHSTGSYIAGY Sbjct: 1541 SSRSQSRVRNIASRAKEKQEANKQKVPNPSNGAGVVLRNKPSAPTPAVNRHSTGSYIAGY 1600 Query: 1639 LKNTKGGGLEGRGIPEGACTALHYGHVDQFCSDNSVLQTEPSSDDKPEIYFLLRL 1693 LKNTKGGGLEGRGIPEGACTALHYGHVDQFCSDNSVLQTEPSSDDKPEIYFLLRL Sbjct: 1601 LKNTKGGGLEGRGIPEGACTALHYGHVDQFCSDNSVLQTEPSSDDKPEIYFLLRL 1655 >gi|195972873 phospholipase C eta 1 isoform c [Homo sapiens] Length = 1002 Score = 2025 bits (5246), Expect = 0.0 Identities = 999/1001 (99%), Positives = 1000/1001 (99%) Query: 1 MADLEVYKNLSPEKVERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSE 60 MADLEVYKNLSPEKVERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSE Sbjct: 1 MADLEVYKNLSPEKVERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSE 60 Query: 61 KAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWI 120 KAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWI Sbjct: 61 KAKILIDSIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWI 120 Query: 121 TGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPR 180 TGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPR Sbjct: 121 TGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPR 180 Query: 181 RKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFL 240 RKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFL Sbjct: 181 RKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFL 240 Query: 241 KVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQD 300 KVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQD Sbjct: 241 KVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQD 300 Query: 301 MDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHG 360 MDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHG Sbjct: 301 MDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHG 360 Query: 361 YTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSS 420 YTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSS Sbjct: 361 YTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSS 420 Query: 421 VDTGECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSN 480 VDTGECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSN Sbjct: 421 VDTGECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSN 480 Query: 481 GTTEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESG 540 GTTEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESG Sbjct: 481 GTTEHQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESG 540 Query: 541 KKSHGRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRE 600 KKSHGRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRE Sbjct: 541 KKSHGRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRE 600 Query: 601 LSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY 660 LSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY Sbjct: 601 LSDLVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY 660 Query: 661 RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNP 720 RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNP Sbjct: 661 RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNP 720 Query: 721 FSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTR 780 FSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTR Sbjct: 721 FSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTR 780 Query: 781 VVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVY 840 VVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVY Sbjct: 781 VVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVY 840 Query: 841 LEGLTEASIFVHITINEIYGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHSS 900 LEGLTEASIFVHITINEIYGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHSS Sbjct: 841 LEGLTEASIFVHITINEIYGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHSS 900 Query: 901 SENNSHYVRKRSIGDRILRRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRT 960 SENNSHYVRKRSIGDRILRRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRT Sbjct: 901 SENNSHYVRKRSIGDRILRRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRT 960 Query: 961 TRSLQARPVSMPVDRNLLGALSLPVSETAKDIEGKENSLAE 1001 TRSLQARPVSMPVDRNLLGALSLPVSETAKDIEGKENSL + Sbjct: 961 TRSLQARPVSMPVDRNLLGALSLPVSETAKDIEGKENSLVQ 1001 >gi|78499633 phospholipase C, eta 2 [Homo sapiens] Length = 1416 Score = 1211 bits (3133), Expect = 0.0 Identities = 599/944 (63%), Positives = 741/944 (78%), Gaps = 30/944 (3%) Query: 15 VERCMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIYKVTE 74 VERCM MQ G QM+KL+ G+KGLVR +YLDEHR+ +RWRPSRK+EKAKI IDSI +V+E Sbjct: 42 VERCMGAMQEGMQMVKLRGGSKGLVRFYYLDEHRSCIRWRPSRKNEKAKISIDSIQEVSE 101 Query: 75 GRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDED 134 GRQSE+F R +G+FDP+CCF+IYHG+H ESLDL++++ E ARTW+TGL+YLMAGISDED Sbjct: 102 GRQSEVFQRYPDGSFDPNCCFSIYHGSHRESLDLVSTSSEVARTWVTGLRYLMAGISDED 161 Query: 135 SLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDE 194 SLA+RQRT DQW+KQTF+EADKNGDG L+I E+ QL+HKLNVNLPR++V+QMF+EADTD+ Sbjct: 162 SLARRQRTRDQWLKQTFDEADKNGDGSLSIGEVLQLLHKLNVNLPRQRVKQMFREADTDD 221 Query: 195 NQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYC 254 +QGTL FEEFC FYKMMS RRDLYLL+L+YS+ KDHL L +FL+VEQKM VT + C Sbjct: 222 HQGTLGFEEFCAFYKMMSTRRDLYLLMLTYSNHKDHLDAASLQRFLQVEQKMAGVTLESC 281 Query: 255 LDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSH 314 DII++FE ENK K +LGI+GFTN+ RSPA DIFNP HH V+QDM QPL +Y+I SSH Sbjct: 282 QDIIEQFEPCPENKSKGLLGIDGFTNYTRSPAGDIFNPEHHHVHQDMTQPLSHYFITSSH 341 Query: 315 NTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVE 374 NTYL GDQL+SQS+VDMYA VLQ GCRCVEVDCWDGPDGEP+VHHGYTLTSKILF+DV+E Sbjct: 342 NTYLVGDQLMSQSRVDMYAWVLQAGCRCVEVDCWDGPDGEPIVHHGYTLTSKILFKDVIE 401 Query: 375 TINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQS 434 TINK+AF+KNE+PVILSIENHCS+ QQ+K+AQYL I GDKLDLSSV + + LPSPQ Sbjct: 402 TINKYAFIKNEYPVILSIENHCSVIQQKKMAQYLTDILGDKLDLSSVSSEDATTLPSPQM 461 Query: 435 LKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKK 494 LKGKILVKGKKLP ++ +DAEEGEVSDEDSADEI+D+CK L+ T +VE+ ++K Sbjct: 462 LKGKILVKGKKLPANISEDAEEGEVSDEDSADEIDDDCKL-LNGDASTNRKRVENTAKRK 520 Query: 495 LESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKE--SGKKSHGRSLMTNF 552 L+SL+KES+IRD EDP++F+V L + G + ++ + E + +GR ++ +F Sbjct: 521 LDSLIKESKIRDCEDPNNFSVSTLSPSGKLGRKSKAEEDVESGEDAGASRRNGRLVVGSF 580 Query: 553 GKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVA 612 + KK K+ S ++ ++ Q S GGQ R++KTMKL R LSDLV YT SVA Sbjct: 581 SRRKKKGSKLKKAASVEEGDEGQDS---PGGQSRGATRQKKTMKLSRALSDLVKYTKSVA 637 Query: 613 AQDI-VDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLP 671 DI ++ ++ V SFSET+AHQ++QQK Q++ +NQ+QL+RIYPS+YR+DSSN+NP P Sbjct: 638 THDIEMEAASSWQVSSFSETKAHQILQQKPAQYLRFNQQQLSRIYPSSYRVDSSNYNPQP 697 Query: 672 YWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDPLPANPK 731 +WNAGCQ+VALNYQSEGRM+QLNRAKF ANG CGYVLKP MC+G FNP S DPLP K Sbjct: 698 FWNAGCQMVALNYQSEGRMLQLNRAKFSANGGCGYVLKPGCMCQGVFNPNSEDPLPGQLK 757 Query: 732 KQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVW 791 KQL+L++ISGQQLPKP DSM GDRGEIIDPFVEVEIIGLPVDC ++QTRVVDDNGFNP W Sbjct: 758 KQLVLRIISGQQLPKPRDSMLGDRGEIIDPFVEVEIIGLPVDCSREQTRVVDDNGFNPTW 817 Query: 792 EETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEGLTEASIFV 851 EETL F VHMPEIALVRFLVWDHDPIGRDF+GQRT+ FSS++PGYRHVYLEG+ EASIFV Sbjct: 818 EETLVFMVHMPEIALVRFLVWDHDPIGRDFIGQRTLAFSSMMPGYRHVYLEGMEEASIFV 877 Query: 852 HITINEIYGKWSPLILNPSYTILHFLGATKNRQLQGLKGLFNKNPRHSSSENNS--HYVR 909 H+ +++I G K +Q GLKGLF + P+ S ++++ Sbjct: 878 HVAVSDISG--------------------KVKQALGLKGLFLRGPKPGSLDSHAAGRPPA 917 Query: 910 KRSIGDRILRRTASAPAKGRKKSKMGFQEMV-EIKDSVSEATRD 952 + S+ RILRRTASAP K +K + GF E+V +D+ S+ D Sbjct: 918 RPSVSQRILRRTASAPTKSQKPGRRGFPELVLGTRDTGSKGVAD 961 Score = 67.4 bits (163), Expect = 1e-10 Identities = 64/184 (34%), Positives = 80/184 (43%), Gaps = 44/184 (23%) Query: 1487 PSPCKSKSLGDLTSEDIACNFESKYQCISKSF-VTTGIRDKKGVTVKTKSLEPIDALTEQ 1545 P KSKSLGDLT++D A +FE + +S S + G R G V+ D LTEQ Sbjct: 1249 PVAAKSKSLGDLTADDFAPSFEGGSRRLSHSLGLPGGTRRVSGPGVRR------DTLTEQ 1302 Query: 1546 LRKLVSFDQEDNCQVLYSKQDANQLPRA---LVRKLSSRSQSRVRNIASRAKEKQEANKQ 1602 LR L F Q + S A + VR+ SSRS SRVR IASRA++ QE ++ Sbjct: 1303 LRWLTVFQQAGDITSPTSLGPAGEGVAGGPGFVRRSSSRSHSRVRAIASRARQAQERQQR 1362 Query: 1603 KVPNPSNGAGVVLRNKPSAPTPAVNRHSTGSYIAGYLKNTKGGGLEGRGIPEGACTALHY 1662 G G +G E RG PEGAC+ H Sbjct: 1363 -----LQGLG-----------------------------RQGPPEEERGTPEGACSVGHE 1388 Query: 1663 GHVD 1666 G VD Sbjct: 1389 GSVD 1392 >gi|221219000 phospholipase C-like 2 isoform 1 [Homo sapiens] Length = 1127 Score = 344 bits (882), Expect = 5e-94 Identities = 189/457 (41%), Positives = 279/457 (61%), Gaps = 9/457 (1%) Query: 18 CMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRK-SEKAKILIDSIYKVTEGR 76 C++ M G+++ K++ ++ R F LD LRW PS+K SEKAKI I SI +V G+ Sbjct: 139 CINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGK 198 Query: 77 QSEIFHRQA-EGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMA-GISDED 134 ++IF C F++ +G + ESLDL+ ++ + A W+TGL+YL++ G D Sbjct: 199 NTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLD 258 Query: 135 SLAKRQ-RTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTD 193 L Q WV Q F E D + G + + Q + LN L K+ F+E Sbjct: 259 MLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKS 318 Query: 194 ENQ-GT-LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTT 251 +++ GT +T EEF + + R ++Y LL+ +S K+ L ++L FL+ EQ + ++ Sbjct: 319 KDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINE 378 Query: 252 DYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIA 311 + L+II K+E S+E + K L I+GFTN++ SP C IF+P H +V QDM QPL +Y+I Sbjct: 379 EISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFIN 438 Query: 312 SSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRD 371 SSHNTYL DQ S + Y R L+ GCR VE+D WDGPD EPV++ G+T+TS+I+FR Sbjct: 439 SSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRS 498 Query: 372 VVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPS 431 V++ INK+AF +E+P+IL +ENHCSI+QQ+ + Q++K + GDKL +S + E LPS Sbjct: 499 VIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEE-SYLPS 557 Query: 432 PQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEI 468 P LKGKIL+K KKL + EG+V+DED E+ Sbjct: 558 PDVLKGKILIKAKKLSSNC--SGVEGDVTDEDEGAEM 592 Score = 227 bits (578), Expect = 8e-59 Identities = 130/331 (39%), Positives = 188/331 (56%), Gaps = 23/331 (6%) Query: 553 GKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRR---------KTMKLCRELSD 603 GK K S + S + + T + G E Q R+G+ K +LC+ELS+ Sbjct: 563 GKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQ--RMGKENMEQPNNVPVKRFQLCKELSE 620 Query: 604 LVVYTNSVAAQDIVDDGTTGN---VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY 660 LV SV ++ V SF+E A + + F+ YN++ L R++PS Sbjct: 621 LVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPM 680 Query: 661 RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT--F 718 RIDSSN NP +W GCQ+VA+N+Q+ G MM LN F+ NGNCGYVL+P M + F Sbjct: 681 RIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFF 740 Query: 719 NPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQ 778 + + D +P + L +K+ISGQ PKP S G +G+++DP+V VEI G+P DC + + Sbjct: 741 SANTKDSVPGVSPQLLHIKIISGQNFPKPKGS--GAKGDVVDPYVYVEIHGIPADCAEQR 798 Query: 779 TRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRH 838 T+ V NG P+++E+ F +++PE+A+VRF+V D D IG +F+GQ T+ F L GYRH Sbjct: 799 TKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRH 858 Query: 839 VYLEGLT-----EASIFVHITINEIYGKWSP 864 V L+ LT AS+FVH+ I G P Sbjct: 859 VPLQSLTGEVLAHASLFVHVAITNRRGGGKP 889 >gi|163644311 phospholipase C-like 2 isoform 2 [Homo sapiens] Length = 1001 Score = 344 bits (882), Expect = 5e-94 Identities = 189/457 (41%), Positives = 279/457 (61%), Gaps = 9/457 (1%) Query: 18 CMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRK-SEKAKILIDSIYKVTEGR 76 C++ M G+++ K++ ++ R F LD LRW PS+K SEKAKI I SI +V G+ Sbjct: 13 CINSMVEGSELKKVRSNSRIYHRYFLLDADMQSLRWEPSKKDSEKAKIDIKSIKEVRTGK 72 Query: 77 QSEIFHRQA-EGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMA-GISDED 134 ++IF C F++ +G + ESLDL+ ++ + A W+TGL+YL++ G D Sbjct: 73 NTDIFRSNGISDQISEDCAFSVIYGENYESLDLVANSADVANIWVTGLRYLISYGKHTLD 132 Query: 135 SLAKRQ-RTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTD 193 L Q WV Q F E D + G + + Q + LN L K+ F+E Sbjct: 133 MLESSQDNMRTSWVSQMFSEIDVDNLGHITLCNAVQCIRNLNPGLKTSKIELKFKELHKS 192 Query: 194 ENQ-GT-LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTT 251 +++ GT +T EEF + + R ++Y LL+ +S K+ L ++L FL+ EQ + ++ Sbjct: 193 KDKAGTEVTKEEFIEVFHELCTRPEIYFLLVQFSSNKEFLDTKDLMMFLEAEQGVAHINE 252 Query: 252 DYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIA 311 + L+II K+E S+E + K L I+GFTN++ SP C IF+P H +V QDM QPL +Y+I Sbjct: 253 EISLEIIHKYEPSKEGQEKGWLSIDGFTNYLMSPDCYIFDPEHKKVCQDMKQPLSHYFIN 312 Query: 312 SSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRD 371 SSHNTYL DQ S + Y R L+ GCR VE+D WDGPD EPV++ G+T+TS+I+FR Sbjct: 313 SSHNTYLIEDQFRGPSDITGYIRALKMGCRSVELDVWDGPDNEPVIYTGHTMTSQIVFRS 372 Query: 372 VVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPS 431 V++ INK+AF +E+P+IL +ENHCSI+QQ+ + Q++K + GDKL +S + E LPS Sbjct: 373 VIDIINKYAFFASEYPLILCLENHCSIKQQKVMVQHMKKLLGDKLYTTSPNVEE-SYLPS 431 Query: 432 PQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEI 468 P LKGKIL+K KKL + EG+V+DED E+ Sbjct: 432 PDVLKGKILIKAKKLSSNC--SGVEGDVTDEDEGAEM 466 Score = 227 bits (578), Expect = 8e-59 Identities = 130/331 (39%), Positives = 188/331 (56%), Gaps = 23/331 (6%) Query: 553 GKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRR---------KTMKLCRELSD 603 GK K S + S + + T + G E Q R+G+ K +LC+ELS+ Sbjct: 437 GKILIKAKKLSSNCSGVEGDVTDEDEGAEMSQ--RMGKENMEQPNNVPVKRFQLCKELSE 494 Query: 604 LVVYTNSVAAQDIVDDGTTGN---VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAY 660 LV SV ++ V SF+E A + + F+ YN++ L R++PS Sbjct: 495 LVSICKSVQFKEFQVSFQVQKYWEVCSFNEVLASKYANENPGDFVNYNKRFLARVFPSPM 554 Query: 661 RIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT--F 718 RIDSSN NP +W GCQ+VA+N+Q+ G MM LN F+ NGNCGYVL+P M + F Sbjct: 555 RIDSSNMNPQDFWKCGCQIVAMNFQTPGLMMDLNIGWFRQNGNCGYVLRPAIMREEVSFF 614 Query: 719 NPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQ 778 + + D +P + L +K+ISGQ PKP S G +G+++DP+V VEI G+P DC + + Sbjct: 615 SANTKDSVPGVSPQLLHIKIISGQNFPKPKGS--GAKGDVVDPYVYVEIHGIPADCAEQR 672 Query: 779 TRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRH 838 T+ V NG P+++E+ F +++PE+A+VRF+V D D IG +F+GQ T+ F L GYRH Sbjct: 673 TKTVHQNGDAPIFDESFEFQINLPELAMVRFVVLDDDYIGDEFIGQYTIPFECLQTGYRH 732 Query: 839 VYLEGLT-----EASIFVHITINEIYGKWSP 864 V L+ LT AS+FVH+ I G P Sbjct: 733 VPLQSLTGEVLAHASLFVHVAITNRRGGGKP 763 >gi|167900452 phospholipase C-like 1 isoform a [Homo sapiens] Length = 1095 Score = 339 bits (869), Expect = 2e-92 Identities = 196/497 (39%), Positives = 293/497 (58%), Gaps = 12/497 (2%) Query: 18 CMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKS-EKAKILIDSIYKVTEGR 76 C+S MQ+G ++ K++ ++ R F LD LRW PS+K EKAK+ I +I ++ G+ Sbjct: 111 CISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGK 170 Query: 77 QSEIFHRQAEGN-FDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDE-D 134 +E F + C F+I HG + ESLDL+ ++ + A W++GL+YL++ D Sbjct: 171 NTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLD 230 Query: 135 SLAKRQRT-HDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTD 193 + Q T W+K FE AD +G+G++ + +L+ +LN L K+R F+E Sbjct: 231 FMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKS 290 Query: 194 ENQGT--LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTT 251 + + T +T EEFC + + R ++Y LL+ S K++L +L FL+ EQ + ++T Sbjct: 291 KEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITE 350 Query: 252 DYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIA 311 D CLDII+++E+SEE + K L I+GFT ++ S CDIF+P +V QDM QPL +YYI Sbjct: 351 DICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYIN 410 Query: 312 SSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRD 371 +SHNTYL DQ + ++ Y R L+ GCR VE+D DG D EP++ + +T+ + FR Sbjct: 411 ASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRS 470 Query: 372 VVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPS 431 V+E INK AFV +E+P+IL + NHCS+ QQ+ +AQ +K +FG+KL + E LPS Sbjct: 471 VIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSE-SYLPS 529 Query: 432 PQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFI 491 P+ LK I+VKGKKLP D EGEV+DED +E E + + Y NG + Sbjct: 530 PEKLKRMIIVKGKKLP--SDPDVLEGEVTDED--EEAEMSRRMSVDY-NGEQKQIRLCRE 584 Query: 492 RKKLESLLKESQIRDKE 508 L S+ K Q RD E Sbjct: 585 LSDLVSICKSVQYRDFE 601 Score = 233 bits (594), Expect = 1e-60 Identities = 129/304 (42%), Positives = 182/304 (59%), Gaps = 18/304 (5%) Query: 568 TDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGN--- 624 TD++E+ + S +K ++LCRELSDLV SV +D + N Sbjct: 556 TDEDEEAEMSRRMS----VDYNGEQKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWE 611 Query: 625 VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNY 684 + SFSET A ++ + E F+ YN+K L+RIYPSA RIDSSN NP +WN GCQ+VA+N+ Sbjct: 612 MCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNF 671 Query: 685 QSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDP---LPANPKKQLILKVISG 741 Q+ G MM L+ F NG CGYVL+P M + + FS + LP L +K+ISG Sbjct: 672 QTPGPMMDLHTGWFLQNGGCGYVLRPSIM-RDEVSYFSANTKGILPGVSPLALHIKIISG 730 Query: 742 QQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHM 801 Q PKP + +G++IDP+V +EI G+P DC + +T+ V N NP+++ET F V++ Sbjct: 731 QNFPKPKGAC--AKGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNL 788 Query: 802 PEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEG-----LTEASIFVHITIN 856 PE+A++RF+V D D IG +F+GQ T+ F L PGYRHV L + ++FVHI I Sbjct: 789 PELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAIT 848 Query: 857 EIYG 860 G Sbjct: 849 NRSG 852 >gi|167900450 phospholipase C-like 1 isoform b [Homo sapiens] Length = 997 Score = 339 bits (869), Expect = 2e-92 Identities = 196/497 (39%), Positives = 293/497 (58%), Gaps = 12/497 (2%) Query: 18 CMSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRKS-EKAKILIDSIYKVTEGR 76 C+S MQ+G ++ K++ ++ R F LD LRW PS+K EKAK+ I +I ++ G+ Sbjct: 13 CISFMQAGCELKKVRPNSRIYNRFFTLDTDLQALRWEPSKKDLEKAKLDISAIKEIRLGK 72 Query: 77 QSEIFHRQAEGN-FDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDE-D 134 +E F + C F+I HG + ESLDL+ ++ + A W++GL+YL++ D Sbjct: 73 NTETFRNNGLADQICEDCAFSILHGENYESLDLVANSADVANIWVSGLRYLVSRSKQPLD 132 Query: 135 SLAKRQRT-HDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTD 193 + Q T W+K FE AD +G+G++ + +L+ +LN L K+R F+E Sbjct: 133 FMEGNQNTPRFMWLKTVFEAADVDGNGIMLEDTSVELIKQLNPTLKEAKIRLKFKEIQKS 192 Query: 194 ENQGT--LTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTT 251 + + T +T EEFC + + R ++Y LL+ S K++L +L FL+ EQ + ++T Sbjct: 193 KEKLTTRVTEEEFCEAFCELCTRPEVYFLLVQISKNKEYLDANDLMLFLEAEQGVTHITE 252 Query: 252 DYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIA 311 D CLDII+++E+SEE + K L I+GFT ++ S CDIF+P +V QDM QPL +YYI Sbjct: 253 DICLDIIRRYELSEEGRQKGFLAIDGFTQYLLSSECDIFDPEQKKVAQDMTQPLSHYYIN 312 Query: 312 SSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRD 371 +SHNTYL DQ + ++ Y R L+ GCR VE+D DG D EP++ + +T+ + FR Sbjct: 313 ASHNTYLIEDQFRGPADINGYIRALKMGCRSVELDVSDGSDNEPILCNRNNMTTHVSFRS 372 Query: 372 VVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPS 431 V+E INK AFV +E+P+IL + NHCS+ QQ+ +AQ +K +FG+KL + E LPS Sbjct: 373 VIEVINKFAFVASEYPLILCLGNHCSLPQQKVMAQQMKKVFGNKLYTEAPLPSE-SYLPS 431 Query: 432 PQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFI 491 P+ LK I+VKGKKLP D EGEV+DED +E E + + Y NG + Sbjct: 432 PEKLKRMIIVKGKKLP--SDPDVLEGEVTDED--EEAEMSRRMSVDY-NGEQKQIRLCRE 486 Query: 492 RKKLESLLKESQIRDKE 508 L S+ K Q RD E Sbjct: 487 LSDLVSICKSVQYRDFE 503 Score = 233 bits (594), Expect = 1e-60 Identities = 129/304 (42%), Positives = 182/304 (59%), Gaps = 18/304 (5%) Query: 568 TDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGN--- 624 TD++E+ + S +K ++LCRELSDLV SV +D + N Sbjct: 458 TDEDEEAEMSRRMS----VDYNGEQKQIRLCRELSDLVSICKSVQYRDFELSMKSQNYWE 513 Query: 625 VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNY 684 + SFSET A ++ + E F+ YN+K L+RIYPSA RIDSSN NP +WN GCQ+VA+N+ Sbjct: 514 MCSFSETEASRIANEYPEDFVNYNKKFLSRIYPSAMRIDSSNLNPQDFWNCGCQIVAMNF 573 Query: 685 QSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGTFNPFSGDP---LPANPKKQLILKVISG 741 Q+ G MM L+ F NG CGYVL+P M + + FS + LP L +K+ISG Sbjct: 574 QTPGPMMDLHTGWFLQNGGCGYVLRPSIM-RDEVSYFSANTKGILPGVSPLALHIKIISG 632 Query: 742 QQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHM 801 Q PKP + +G++IDP+V +EI G+P DC + +T+ V N NP+++ET F V++ Sbjct: 633 QNFPKPKGAC--AKGDVIDPYVCIEIHGIPADCSEQRTKTVQQNSDNPIFDETFEFQVNL 690 Query: 802 PEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEG-----LTEASIFVHITIN 856 PE+A++RF+V D D IG +F+GQ T+ F L PGYRHV L + ++FVHI I Sbjct: 691 PELAMIRFVVLDDDYIGDEFIGQYTIPFECLQPGYRHVPLRSFVGDIMEHVTLFVHIAIT 750 Query: 857 EIYG 860 G Sbjct: 751 NRSG 754 >gi|14249340 phospholipase C, delta 4 [Homo sapiens] Length = 762 Score = 337 bits (863), Expect = 8e-92 Identities = 187/456 (41%), Positives = 277/456 (60%), Gaps = 7/456 (1%) Query: 21 VMQSGTQMIKLKRGTKGLVRLFYL-DEHRTRLRWRPSRKSEKAKILIDSIYKVTEGRQSE 79 +MQ G M K++ + +R F L ++ T R +R S K I + + G SE Sbjct: 17 LMQEGMPMRKVRSKSWKKLRYFRLQNDGMTVWHARQARGSAKPSFSISDVETIRNGHDSE 76 Query: 80 IFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKR 139 + AE FTI +LDL+ ++ EEA+ W+ GL+ L+ ++ D Sbjct: 77 LLRSLAE-ELPLEQGFTIVFHGRRSNLDLMANSVEEAQIWMRGLQLLVDLVTSMD----H 131 Query: 140 QRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTL 199 Q DQW+ F+ DKN DG ++ +E+ +L+H +NV + + +FQ ADT ++ GTL Sbjct: 132 QERLDQWLSDWFQRGDKNQDGKMSFQEVQRLLHLMNVEMDQEYAFSLFQAADTSQS-GTL 190 Query: 200 TFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDIIK 259 EEF FYK ++ R ++ L S+S LT+ E FL+ EQK + T++ L++I Sbjct: 191 EGEEFVQFYKALTKRAEVQELFESFSADGQKLTLLEFLDFLQEEQKERDCTSELALELID 250 Query: 260 KFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLT 319 ++E S+ K+++VL ++GF +++ S DIFNP +YQDM QPL +Y+I SSHNTYL Sbjct: 251 RYEPSDSGKLRHVLSMDGFLSYLCSKDGDIFNPACLPIYQDMTQPLNHYFICSSHNTYLV 310 Query: 320 GDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKH 379 GDQL QS V+ Y R L+ GCRCVEVD WDGP GEPVV+HG+TLTS+ILF+DVV T+ ++ Sbjct: 311 GDQLCGQSSVEGYIRALKRGCRCVEVDVWDGPSGEPVVYHGHTLTSRILFKDVVATVAQY 370 Query: 380 AFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKI 439 AF +++PVILS+E HCS +QQ+ +A++L I G++L +++D QLPSP+ L+ KI Sbjct: 371 AFQTSDYPVILSLETHCSWEQQQTMARHLTEILGEQLLSTTLDGVLPTQLPSPEELRRKI 430 Query: 440 LVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFK 475 LVKGKKL + EE E E E+ E +F+ Sbjct: 431 LVKGKKLTLEEDLEYEEEEAEPELEESELALESQFE 466 Score = 209 bits (531), Expect = 2e-53 Identities = 118/303 (38%), Positives = 180/303 (59%), Gaps = 23/303 (7%) Query: 566 YSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGN- 624 + T+ E Q K+ +++ LC LS LV+Y SV+ + + Sbjct: 465 FETEPEPQEQNLQNKDK-------KKKSKPILCPALSSLVIYLKSVSFRSFTHSKEHYHF 517 Query: 625 --VLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVAL 682 + SFSET+A +++++ +F+ +N QL+R+YPS R DSSN+NP WNAGCQ+VA+ Sbjct: 518 YEISSFSETKAKRLIKEAGNEFVQHNTWQLSRVYPSGLRTDSSNYNPQELWNAGCQMVAM 577 Query: 683 NYQSEGRMMQLNRAKFKANGNCGYVLKPQQM--CKGTFNPFSGDPLPANPKKQLILKVIS 740 N Q+ G M + F+ NG CGYVLKP + + +F+P P+ + L+++VIS Sbjct: 578 NMQTAGLEMDICDGHFRQNGGCGYVLKPDFLRDIQSSFHP--EKPISPFKAQTLLIQVIS 635 Query: 741 GQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVH 800 GQQLPK + G I+DP V+V+I G+ +D + +T V++NGFNP W +TL F V Sbjct: 636 GQQLPKVDKT---KEGSIVDPLVKVQIFGVRLDTARQETNYVENNGFNPYWGQTLCFRVL 692 Query: 801 MPEIALVRFLVWDHDPIGR-DFVGQRTVTFSSLVPGYRHVYL-----EGLTEASIFVHIT 854 +PE+A++RF+V D+D R DF+GQ T+ ++ + GYRH++L L ASIFV+I Sbjct: 693 VPELAMLRFVVMDYDWKSRNDFIGQYTLPWTCMQQGYRHIHLLSKDGISLRPASIFVYIC 752 Query: 855 INE 857 I E Sbjct: 753 IQE 755 >gi|33469933 phospholipase C beta 4 isoform a [Homo sapiens] Length = 1194 Score = 330 bits (845), Expect = 9e-90 Identities = 247/785 (31%), Positives = 387/785 (49%), Gaps = 115/785 (14%) Query: 108 LITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEI 167 ++ NPE + W+ GL+ ++ ++++ W+K F N +G + + I Sbjct: 114 MVAENPEVTKQWVEGLRSIIHNFR-ANNVSPMTCLKKHWMKLAFMT---NTNGKIPVRSI 169 Query: 168 HQLMHKLNVNLPRRKVRQMFQE-----ADTDENQGT-LTFEEFCVFYKMMSLRRDLYLLL 221 + + + Q +E DE + T ++E+F + + R D+ L Sbjct: 170 TRTFAS---GKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLF 226 Query: 222 LSYS-DKKDHLTVEELAQFLKVEQK---MNNVTTDY-----CLDIIKKFEVSEENKVKNV 272 + DK D+LTV++L FL Q+ +N + + + II+ +E E+ K K + Sbjct: 227 KKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGL 286 Query: 273 LGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMY 332 + +GF ++ S E+YQ+MD PL +Y+I+SSHNTYLTG Q +S V+MY Sbjct: 287 ISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMY 346 Query: 333 ARVLQEGCRCVEVDCWDGP--DGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVIL 390 +VL GCRCVE+DCWDG D EP++ HG + + ILF+DV++ I + AFV +E+PVIL Sbjct: 347 RQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVIL 406 Query: 391 SIENHCSIQQQRKIAQYLKGIFGD---KLDLSSVDTGECKQLPSPQSLKGKILVKGKKLP 447 S ENHCS QQ K+++Y + +FGD K L S + LPSP LK KIL+K K+L Sbjct: 407 SFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLK 466 Query: 448 YHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESLLKESQIRDK 507 E+E +K+LE+L + + Sbjct: 467 ------------------PEVE----------------------KKQLEALRSMMEAGES 486 Query: 508 EDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSH--GRSLMTNFGKHKKTT-KSRSK 564 P + E N +S D +E G L + HK+ S K Sbjct: 487 ASPANIL---------EDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKK 537 Query: 565 SYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDI---VDDGT 621 T ++E ++ K G T + LS ++ Y V Q + Sbjct: 538 GLVTVEDEQAWMASYKYVGA---------TTNIHPYLSTMINYAQPVKFQGFHVAEERNI 588 Query: 622 TGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVA 681 N+ SF+E+ ++ + +F+ YN++Q++RIYP R+DSSN+ P +WNAGCQ+V+ Sbjct: 589 HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS 648 Query: 682 LNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCK--GTFNPFSGDPLPANPKKQLILKVI 739 LNYQ+ MQLN+ KF+ NG+CGY+LKP M + TF+PFS P+ ++VI Sbjct: 649 LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI 708 Query: 740 SGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQ--TRVVDDNGFNPVW-EETLT 796 SGQ L + I +VEV++ GLP D + + TR+V +NG NPV+ EE+ Sbjct: 709 SGQFL----------SDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFV 758 Query: 797 F-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEG-----LTEASIF 850 F V +P++A++R V+D + +GQR + L GYRH+ L L+ +IF Sbjct: 759 FRKVILPDLAVLRIAVYDDN---NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIF 815 Query: 851 VHITI 855 +I + Sbjct: 816 CNIVL 820 >gi|33469939 phospholipase C beta 4 isoform b [Homo sapiens] Length = 1175 Score = 330 bits (845), Expect = 9e-90 Identities = 247/785 (31%), Positives = 387/785 (49%), Gaps = 115/785 (14%) Query: 108 LITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEI 167 ++ NPE + W+ GL+ ++ ++++ W+K F N +G + + I Sbjct: 114 MVAENPEVTKQWVEGLRSIIHNFR-ANNVSPMTCLKKHWMKLAFMT---NTNGKIPVRSI 169 Query: 168 HQLMHKLNVNLPRRKVRQMFQE-----ADTDENQGT-LTFEEFCVFYKMMSLRRDLYLLL 221 + + + Q +E DE + T ++E+F + + R D+ L Sbjct: 170 TRTFAS---GKTEKVIFQALKELGLPSGKNDEIEPTAFSYEKFYELTQKICPRTDIEDLF 226 Query: 222 LSYS-DKKDHLTVEELAQFLKVEQK---MNNVTTDY-----CLDIIKKFEVSEENKVKNV 272 + DK D+LTV++L FL Q+ +N + + + II+ +E E+ K K + Sbjct: 227 KKINGDKTDYLTVDQLVSFLNEHQRDPRLNEILFPFYDAKRAMQIIEMYEPDEDLKKKGL 286 Query: 273 LGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMY 332 + +GF ++ S E+YQ+MD PL +Y+I+SSHNTYLTG Q +S V+MY Sbjct: 287 ISSDGFCRYLMSDENAPVFLDRLELYQEMDHPLAHYFISSSHNTYLTGRQFGGKSSVEMY 346 Query: 333 ARVLQEGCRCVEVDCWDGP--DGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVIL 390 +VL GCRCVE+DCWDG D EP++ HG + + ILF+DV++ I + AFV +E+PVIL Sbjct: 347 RQVLLAGCRCVELDCWDGKGEDQEPIITHGKAMCTDILFKDVIQAIKETAFVTSEYPVIL 406 Query: 391 SIENHCSIQQQRKIAQYLKGIFGD---KLDLSSVDTGECKQLPSPQSLKGKILVKGKKLP 447 S ENHCS QQ K+++Y + +FGD K L S + LPSP LK KIL+K K+L Sbjct: 407 SFENHCSKYQQYKMSKYCEDLFGDLLLKQALESHPLEPGRALPSPNDLKRKILIKNKRLK 466 Query: 448 YHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVESFIRKKLESLLKESQIRDK 507 E+E +K+LE+L + + Sbjct: 467 ------------------PEVE----------------------KKQLEALRSMMEAGES 486 Query: 508 EDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSH--GRSLMTNFGKHKKTT-KSRSK 564 P + E N +S D +E G L + HK+ S K Sbjct: 487 ASPANIL---------EDDNEEEIESADQEEEAHPEFKFGNELSADDLGHKEAVANSVKK 537 Query: 565 SYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDI---VDDGT 621 T ++E ++ K G T + LS ++ Y V Q + Sbjct: 538 GLVTVEDEQAWMASYKYVGA---------TTNIHPYLSTMINYAQPVKFQGFHVAEERNI 588 Query: 622 TGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVA 681 N+ SF+E+ ++ + +F+ YN++Q++RIYP R+DSSN+ P +WNAGCQ+V+ Sbjct: 589 HYNMSSFNESVGLGYLKTHAIEFVNYNKRQMSRIYPKGGRVDSSNYMPQIFWNAGCQMVS 648 Query: 682 LNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCK--GTFNPFSGDPLPANPKKQLILKVI 739 LNYQ+ MQLN+ KF+ NG+CGY+LKP M + TF+PFS P+ ++VI Sbjct: 649 LNYQTPDLAMQLNQGKFEYNGSCGYLLKPDFMRRPDRTFDPFSETPVDGVIAATCSVQVI 708 Query: 740 SGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQ--TRVVDDNGFNPVW-EETLT 796 SGQ L + I +VEV++ GLP D + + TR+V +NG NPV+ EE+ Sbjct: 709 SGQFL----------SDKKIGTYVEVDMYGLPTDTIRKEFRTRMVMNNGLNPVYNEESFV 758 Query: 797 F-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEG-----LTEASIF 850 F V +P++A++R V+D + +GQR + L GYRH+ L L+ +IF Sbjct: 759 FRKVILPDLAVLRIAVYDDN---NKLIGQRILPLDGLQAGYRHISLRNEGNKPLSLPTIF 815 Query: 851 VHITI 855 +I + Sbjct: 816 CNIVL 820 >gi|117168250 phospholipase C, epsilon 1 [Homo sapiens] Length = 2302 Score = 307 bits (787), Expect = 5e-83 Identities = 222/667 (33%), Positives = 333/667 (49%), Gaps = 80/667 (11%) Query: 235 ELAQFLKVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNF-MRSPACDIFNPL 293 +L FL V + + T D L II+KFE S + ++ EGF F M N Sbjct: 1328 QLNDFL-VNCQGEHCTYDEILSIIQKFEPSISMCHQGLMSFEGFARFLMDKENFASKNDE 1386 Query: 294 HHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDG 353 E +++ PL YYI SSHNTYLTG QL +S V++Y++VL +GCR VE+DCWDG DG Sbjct: 1387 SQENIKELQLPLSYYYIESSHNTYLTGHQLKGESSVELYSQVLLQGCRSVELDCWDGDDG 1446 Query: 354 EPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFG 413 P+++HG+TLT+KI F++VVE I++ AF+ ++ P+I+SIENHCS+ QQRK+A+ K +FG Sbjct: 1447 MPIIYHGHTLTTKIPFKEVVEAIDRSAFINSDLPIIISIENHCSLPQQRKMAEIFKTVFG 1506 Query: 414 DKL---DLSSVDTGECKQLPSPQSLKGKILVKGKKLPYHL-------------------- 450 +KL L D + LPSP L+ K+L+K KKL H Sbjct: 1507 EKLVTKFLFETDFSDDPMLPSPDQLRKKVLLKNKKLKAHQTPVDILKQKAHQLASMQVQA 1566 Query: 451 --GDDAEEGEVSDEDSADEIEDE----------------------CKFKLHYSNGTTEHQ 486 G +A ++E+ DE EDE C KL + + Sbjct: 1567 YNGGNANPRPANNEEEEDE-EDEYDYDYESLSDDNILEDRPENKSCNDKLQFE---YNEE 1622 Query: 487 VESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHE---GLNAHLKQSPDVKESGKKS 543 + I+K S + ++ D E + F + K + + L+ + VK G + Sbjct: 1623 IPKRIKKADNSACNKGKVYDMELGEEFYLDQNKKESRQIAPELSDLVIYCQAVKFPGLST 1682 Query: 544 HGRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSD 603 S ++ GK +K+ KS + S K G+ G R + E S Sbjct: 1683 LNAS-GSSRGKERKSRKSIFGNNPGRMSPGETASFNKTSGKSSCEGIR----QTWEESSS 1737 Query: 604 LVVYTNSVAAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRID 663 + T S++A I+ ++ S +E A ++ ++ S++ + QL R YP+A RID Sbjct: 1738 PLNPTTSLSA--IIRTPKCYHISSLNENAAKRLCRRYSQKLTQHTACQLLRTYPAATRID 1795 Query: 664 SSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT------ 717 SSN NPL +W G QLVALNYQ++ + LN A F+ANG CGYVLKP + Sbjct: 1796 SSNPNPLMFWLHGIQLVALNYQTDDLPLHLNAAMFEANGGCGYVLKPPVLWDKNCPMYQK 1855 Query: 718 FNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKD 777 F+P D L + L ++SGQ + P +SM P +EV+++G+P+D C Sbjct: 1856 FSPLERD-LDSMDPAVYSLTIVSGQNV-CPSNSMG-------SPCIEVDVLGMPLDSCHF 1906 Query: 778 QTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYR 837 +T+ + N NP+W E F VH ++ +RF V +++ QR + +L GYR Sbjct: 1907 RTKPIHRNTLNPMWNEQFLFHVHFEDLVFLRFAVVENN--SSAVTAQRIIPLKALKRGYR 1964 Query: 838 HVYLEGL 844 H+ L L Sbjct: 1965 HLQLRNL 1971 >gi|19115964 phospholipase C delta 3 [Homo sapiens] Length = 789 Score = 295 bits (755), Expect = 3e-79 Identities = 171/463 (36%), Positives = 260/463 (56%), Gaps = 15/463 (3%) Query: 22 MQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRW--RPSRKSEKAKILIDSIYKVTEGRQSE 79 M G+++ K++ T RL+ L E + + R R + + I V EG QSE Sbjct: 65 MLRGSRLRKIRSRTWHKERLYRLQEDGLSVWFQRRIPRAPSQHIFFVQHIEAVREGHQSE 124 Query: 80 IFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKR 139 R G F P+ C TI ++LDL EEA+ W+ GL L A + D++++R Sbjct: 125 GLRRFG-GAFAPARCLTIAFKGRRKNLDLAAPTAEEAQRWVRGLTKLRARL---DAMSQR 180 Query: 140 QRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTL 199 +R D W+ AD N D ++ +EI L+ +NV++ +F+E D N L Sbjct: 181 ERL-DHWIHSYLHRADSNQDSKMSFKEIKSLLRMVNVDMNDMYAYLLFKECDHSNND-RL 238 Query: 200 TFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDIIK 259 E F + + R +L + YS + L+ EL +FL+ +Q T +I+ Sbjct: 239 EGAEIEEFLRRLLKRPELEEIFHQYSGEDRVLSAPELLEFLE-DQGEEGATLARAQQLIQ 297 Query: 260 KFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLT 319 +E++E K ++ ++GF ++ SP + H V+QDM+QPL +Y+I+SSHNTYLT Sbjct: 298 TYELNETAKQHELMTLDGFMMYLLSPEGAALDNTHTCVFQDMNQPLAHYFISSSHNTYLT 357 Query: 320 GDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKH 379 Q+ S + Y R +GCRCVE+DCW+GP GEPV++HG+TLTSKILFRDVV+ + H Sbjct: 358 DSQIGGPSSTEAYVRAFAQGCRCVELDCWEGPGGEPVIYHGHTLTSKILFRDVVQAVRDH 417 Query: 380 AFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKI 439 AF + +PVILS+ENHC ++QQ +A++L I GD L ++D+ ++LPSP+ LKG++ Sbjct: 418 AFTLSPYPVILSLENHCGLEQQAAMARHLCTILGDMLVTQALDSPNPEELPSPEQLKGRV 477 Query: 440 LVKGKKLPYHLGDDA------EEGEVSDEDSADEIEDECKFKL 476 LVKGKKLP +D EE E DE+ +E+E + +L Sbjct: 478 LVKGKKLPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQRRL 520 Score = 209 bits (532), Expect = 2e-53 Identities = 127/339 (37%), Positives = 192/339 (56%), Gaps = 31/339 (9%) Query: 533 SPDVKESGKKSHGRSLMTNFGKHKKTTKSRSKS-YSTDDEEDTQQSTGKEGGQLYRLGRR 591 +P+ S ++ GR L+ K KK +RS+ + D E+ ++ +E ++ +R Sbjct: 463 NPEELPSPEQLKGRVLV----KGKKLPAARSEDGRALSDREEEEEDDEEEEEEVEAAAQR 518 Query: 592 RKTMKLCRELSDLVVYTNSVAAQDIVDDGTTGN---VLSFSETRAHQVVQQKSEQFMIYN 648 R ++ ELS L VY ++ + + V S SE +A +++++ F+ +N Sbjct: 519 RLAKQISPELSALAVYCHATRLRTLHPAPNAPQPCQVSSLSERKAKKLIREAGNSFVRHN 578 Query: 649 QKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVL 708 +QLTR+YP R++S+N++P WN+GCQLVALN+Q+ G M LN +F NG CGYVL Sbjct: 579 ARQLTRVYPLGLRMNSANYSPQEMWNSGCQLVALNFQTPGYEMDLNAGRFLVNGQCGYVL 638 Query: 709 KPQ--QMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPK----PPDSMFGDRGEIIDPF 762 KP + TF+P P P+ L ++V++ QQLPK P S I+DP Sbjct: 639 KPACLRQPDSTFDP----EYPGPPRTTLSIQVLTAQQLPKLNAEKPHS-------IVDPL 687 Query: 763 VEVEIIGLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIG-RDF 821 V +EI G+P DC + +T V +NGFNP W +TL F + PE+ALVRF+V D+D DF Sbjct: 688 VRIEIHGVPADCARQETDYVLNNGFNPRWGQTLQFQLRAPELALVRFVVEDYDATSPNDF 747 Query: 822 VGQRTVTFSSLVPGYRHVYL-----EGLTEASIFVHITI 855 VGQ T+ SSL GYRH++L L+ A++F+ I I Sbjct: 748 VGQFTLPLSSLKQGYRHIHLLSKDGASLSPATLFIQIRI 786 >gi|90265805 phospholipase C, delta 1 isoform 2 [Homo sapiens] Length = 756 Score = 293 bits (750), Expect = 1e-78 Identities = 170/461 (36%), Positives = 260/461 (56%), Gaps = 16/461 (3%) Query: 19 MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRK----SEKAKILIDSIYKVTE 74 + + G+Q++K+K + R + L E + W+ SRK E I+ I +V Sbjct: 19 LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFSIEDIQEVRM 77 Query: 75 GRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDED 134 G ++E + A + CF+I + +LDLI +P +A+ W+ GL + I Sbjct: 78 GHRTEGLEKFAR-DVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKI---IHHSG 133 Query: 135 SLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDE 194 S+ +RQ+ W+ +ADKN D ++ +E+ + +LN+ + R++F+E D + Sbjct: 134 SMDQRQKLQ-HWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQ 192 Query: 195 NQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYC 254 +L EE FYKM++ R ++ + + L+V++L FL+ +Q+ Sbjct: 193 TD-SLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALA 251 Query: 255 LDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSH 314 L +I+++E SE K + + +GF ++ S F+ H VYQDM QPL +Y ++SSH Sbjct: 252 LSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSH 311 Query: 315 NTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVE 374 NTYL DQL S + Y R L +GCRC+E+DCWDGP+ EP+++HGYT TSKILF DV+ Sbjct: 312 NTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLR 371 Query: 375 TINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQS 434 I +AF + +PVILS+ENHC+++QQR +A++L I G L +D G LPSP+ Sbjct: 372 AIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLD-GVTNSLPSPEQ 430 Query: 435 LKGKILVKGKKLPYHLGDDAEEGE----VSDEDSADEIEDE 471 LKGKIL+KGKKL L E G VSDED A E+EDE Sbjct: 431 LKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDE 471 Score = 210 bits (534), Expect = 1e-53 Identities = 117/275 (42%), Positives = 171/275 (62%), Gaps = 16/275 (5%) Query: 595 MKLCRELSDLVVYTNSVAAQDIVDDGTTGNVL----SFSETRAHQVVQQKSEQFMIYNQK 650 ++L +ELSD+V+Y SV GT G SFSE RA +++Q+ F+ +N Sbjct: 486 LRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVG 545 Query: 651 QLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKP 710 L+RIYP+ +R DSSN++P+ WN GCQ+VALN+Q+ G M + + +F+ NG CGYVLKP Sbjct: 546 HLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKP 605 Query: 711 QQM--CKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEII 768 + GTFNP + P +K+L ++VISGQQLPK + ++ I+DP V VEI Sbjct: 606 AFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPK----VNKNKNSIVDPKVTVEIH 661 Query: 769 GLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGR-DFVGQRTV 827 G+ D QT V+ +NGFNP W+ F V +P++AL+RFLV D+D + DF+GQ T+ Sbjct: 662 GVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTI 721 Query: 828 TFSSLVPGYRHVYL-----EGLTEASIFVHITINE 857 +SL GYRHV+L + A++FV I++ + Sbjct: 722 PLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD 756 >gi|195972883 phospholipase C, delta 1 isoform 1 [Homo sapiens] Length = 777 Score = 293 bits (750), Expect = 1e-78 Identities = 170/461 (36%), Positives = 260/461 (56%), Gaps = 16/461 (3%) Query: 19 MSVMQSGTQMIKLKRGTKGLVRLFYLDEHRTRLRWRPSRK----SEKAKILIDSIYKVTE 74 + + G+Q++K+K + R + L E + W+ SRK E I+ I +V Sbjct: 40 LQALLKGSQLLKVKSSSWRRERFYKLQEDCKTI-WQESRKVMRTPESQLFSIEDIQEVRM 98 Query: 75 GRQSEIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAGISDED 134 G ++E + A + CF+I + +LDLI +P +A+ W+ GL + I Sbjct: 99 GHRTEGLEKFAR-DVPEDRCFSIVFKDQRNTLDLIAPSPADAQHWVLGLHKI---IHHSG 154 Query: 135 SLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDE 194 S+ +RQ+ W+ +ADKN D ++ +E+ + +LN+ + R++F+E D + Sbjct: 155 SMDQRQKLQ-HWIHSCLRKADKNKDNKMSFKELQNFLKELNIQVDDSYARKIFRECDHSQ 213 Query: 195 NQGTLTFEEFCVFYKMMSLRRDLYLLLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYC 254 +L EE FYKM++ R ++ + + L+V++L FL+ +Q+ Sbjct: 214 TD-SLEDEEIEAFYKMLTQRVEIDRTFAEAAGSGETLSVDQLVTFLQHQQREEAAGPALA 272 Query: 255 LDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSH 314 L +I+++E SE K + + +GF ++ S F+ H VYQDM QPL +Y ++SSH Sbjct: 273 LSLIERYEPSETAKAQRQMTKDGFLMYLLSADGSAFSLAHRRVYQDMGQPLSHYLVSSSH 332 Query: 315 NTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVE 374 NTYL DQL S + Y R L +GCRC+E+DCWDGP+ EP+++HGYT TSKILF DV+ Sbjct: 333 NTYLLEDQLAGPSSTEAYIRALCKGCRCLELDCWDGPNQEPIIYHGYTFTSKILFCDVLR 392 Query: 375 TINKHAFVKNEFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQS 434 I +AF + +PVILS+ENHC+++QQR +A++L I G L +D G LPSP+ Sbjct: 393 AIRDYAFKASPYPVILSLENHCTLEQQRVMARHLHAILGPMLLNRPLD-GVTNSLPSPEQ 451 Query: 435 LKGKILVKGKKLPYHLGDDAEEGE----VSDEDSADEIEDE 471 LKGKIL+KGKKL L E G VSDED A E+EDE Sbjct: 452 LKGKILLKGKKLGGLLPPGGEGGPEATVVSDEDEAAEMEDE 492 Score = 210 bits (534), Expect = 1e-53 Identities = 117/275 (42%), Positives = 171/275 (62%), Gaps = 16/275 (5%) Query: 595 MKLCRELSDLVVYTNSVAAQDIVDDGTTGNVL----SFSETRAHQVVQQKSEQFMIYNQK 650 ++L +ELSD+V+Y SV GT G SFSE RA +++Q+ F+ +N Sbjct: 507 LRLAQELSDMVIYCKSVHFGGFSSPGTPGQAFYEMASFSENRALRLLQESGNGFVRHNVG 566 Query: 651 QLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKP 710 L+RIYP+ +R DSSN++P+ WN GCQ+VALN+Q+ G M + + +F+ NG CGYVLKP Sbjct: 567 HLSRIYPAGWRTDSSNYSPVEMWNGGCQIVALNFQTPGPEMDVYQGRFQDNGACGYVLKP 626 Query: 711 QQM--CKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEII 768 + GTFNP + P +K+L ++VISGQQLPK + ++ I+DP V VEI Sbjct: 627 AFLRDPNGTFNPRALAQGPWWARKRLNIRVISGQQLPK----VNKNKNSIVDPKVTVEIH 682 Query: 769 GLPVDCCKDQTRVVDDNGFNPVWEETLTFTVHMPEIALVRFLVWDHDPIGR-DFVGQRTV 827 G+ D QT V+ +NGFNP W+ F V +P++AL+RFLV D+D + DF+GQ T+ Sbjct: 683 GVSRDVASRQTAVITNNGFNPWWDTEFAFEVVVPDLALIRFLVEDYDASSKNDFIGQSTI 742 Query: 828 TFSSLVPGYRHVYL-----EGLTEASIFVHITINE 857 +SL GYRHV+L + A++FV I++ + Sbjct: 743 PLNSLKQGYRHVHLMSKNGDQHPSATLFVKISLQD 777 >gi|11386139 phospholipase C beta 3 [Homo sapiens] Length = 1234 Score = 285 bits (730), Expect = 2e-76 Identities = 227/665 (34%), Positives = 328/665 (49%), Gaps = 71/665 (10%) Query: 200 TFEEFCVFYKMMSLRRDLYLLLLSYSDK-KDHLTVEELAQFLKVEQK---MNNVT----- 250 + E F F + LR D+ +LL K K +LT+E+L F+ +Q+ +N V Sbjct: 209 SLEIFERFLNKLCLRPDIDKILLEIGAKGKPYLTLEQLMDFINQKQRDPRLNEVLYPPLR 268 Query: 251 TDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYI 310 +I+K+E +++ ++ + +EGF+ ++ I ++ DM QPL Y+I Sbjct: 269 PSQARLLIEKYEPNQQFLERDQMSMEGFSRYLGGEENGILPLEALDLSTDMTQPLSAYFI 328 Query: 311 ASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVEVDCWDG--PDGEPVVHHGYTLTSKIL 368 SSHNTYLT QL S V+MY + L GCRCVE+D W G P+ EP + HG+T+T+++ Sbjct: 329 NSSHNTYLTAGQLAGTSSVEMYRQALLWGCRCVELDVWKGRPPEEEPFITHGFTMTTEVP 388 Query: 369 FRDVVETINKHAFVKNEFPVILSIENHC-SIQQQRKIAQYLKGIFGDKLDLSSVD---TG 424 RDV+E I + AF + +PVILS ENH S +QQ K+A+Y + IFGD L + +D Sbjct: 389 LRDVLEAIAETAFKTSPYPVILSFENHVDSAKQQAKMAEYCRSIFGDALLIEPLDKYPLA 448 Query: 425 ECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTE 484 LPSPQ L G+ILVK KK DSA K L SN Sbjct: 449 PGVPLPSPQDLMGRILVKNKK--------RHRPSAGGPDSAGR-----KRPLEQSNSALS 495 Query: 485 HQVESFIRKKLESLLKESQIRDKEDPDSFTVRALLKATHEGLNAHLKQSPDVKESGKKSH 544 S E P S + L GL + P ++ +KS Sbjct: 496 E----------SSAATEPSSPQLGSPSSDSCPGLSNGEEVGL-----EKPSLEP--QKSL 538 Query: 545 GRSLMTNFGKHKKTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDL 604 G + N G + R +DEE+ +Q+ K+ G + E+S L Sbjct: 539 GDEGL-NRGPYVLGPADRED--EEEDEEEEEQTDPKK--PTTDEGTASSEVNATEEMSTL 593 Query: 605 VVYTNSVAAQDIV---DDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYR 661 V Y V + + SF ET+A + + + +F+ YN++QL+RIYP R Sbjct: 594 VNYIEPVKFKSFEAARKRNKCFEMSSFVETKAMEQLTKSPMEFVEYNKQQLSRIYPKGTR 653 Query: 662 IDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCK--GTFN 719 +DSSN+ P +WN GCQLVALN+Q+ MQLN F+ NG GY+LKP+ M + +F+ Sbjct: 654 VDSSNYMPQLFWNVGCQLVALNFQTLDVAMQLNAGVFEYNGRSGYLLKPEFMRRPDKSFD 713 Query: 720 PFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDC-CKDQ 778 PF+ + L +KVISGQ L DR + +VEV++ GLPVD K + Sbjct: 714 PFTEVIVDGIVANALRVKVISGQFL--------SDRK--VGIYVEVDMFGLPVDTRRKYR 763 Query: 779 TRVVDDNGFNPVW-EETLTF-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGY 836 TR N FNPVW EE F V +P +A +R ++ G FVG R + S++ GY Sbjct: 764 TRTSQGNSFNPVWDEEPFDFPKVVLPTLASLRIAAFEE---GGKFVGHRILPVSAIRSGY 820 Query: 837 RHVYL 841 +V L Sbjct: 821 HYVCL 825 >gi|25188201 phospholipase C, zeta 1 [Homo sapiens] Length = 608 Score = 244 bits (623), Expect = 5e-64 Identities = 125/287 (43%), Positives = 187/287 (65%), Gaps = 2/287 (0%) Query: 160 GLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEFCVFYKMMSLRRDLYL 219 G +N+E+ +L+ KL++ V+Q+F++ D + QG +T EEF Y++++ R ++ Sbjct: 17 GKINLEKTQRLLEKLDIRCSYIHVKQIFKDNDRLK-QGRITIEEFRAIYRIITHREEIIE 75 Query: 220 LLLSYSDKKDHLTVEELAQFLKVEQKMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFT 279 + +YS+ + L LAQFL EQ ++ +II+K+E EE + + + +EGFT Sbjct: 76 IFNTYSENRKILLASNLAQFLTQEQYAAEMSKAIAFEIIQKYEPIEEVRKAHQMSLEGFT 135 Query: 280 NFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEG 339 +M S C +F +VYQDM PL +Y+I+SSHNTYL DQLL S + Y L +G Sbjct: 136 RYMDSRECLLFKNECRKVYQDMTHPLNDYFISSSHNTYLVSDQLLGPSDLWGYVSALVKG 195 Query: 340 CRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQ 399 CRC+E+DCWDG EPVV+HGYTLTSK+LF+ V++ I+K+AF+ +++PV+LS+ENHCS Sbjct: 196 CRCLEIDCWDGAQNEPVVYHGYTLTSKLLFKTVIQAIHKYAFMTSDYPVVLSLENHCSTA 255 Query: 400 QQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKILVKGKKL 446 QQ +A L+ FG+ L LS + LPSP++LK KILVK KK+ Sbjct: 256 QQEVMADNLQATFGESL-LSDMLDDFPDTLPSPEALKFKILVKNKKI 301 Score = 187 bits (475), Expect = 7e-47 Identities = 118/313 (37%), Positives = 169/313 (53%), Gaps = 29/313 (9%) Query: 557 KTTKSRSKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTN-----SV 611 K T R S D +D + K G + ++ + +K+ LSDLV+YT S Sbjct: 305 KETHERKGSDKRGDNQDKETGVKKLPGVMLFKKKKTRKLKIALALSDLVIYTKAEKFKSF 364 Query: 612 AAQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLP 671 + N S ET+A ++ + + +F+ + +K +TRIYP A R DSSNFNP Sbjct: 365 QHSRLYQQFNENN--SIGETQARKLSKLRVHEFIFHTRKFITRIYPKATRADSSNFNPQE 422 Query: 672 YWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQ--QMCKGTFNPFS---GDPL 726 +WN GCQ+VALN+Q+ G M L KF NG GY+LKP + K FNP + G P+ Sbjct: 423 FWNIGCQMVALNFQTPGLPMDLQNGKFLDNGGSGYILKPHFLRESKSYFNPSNIKEGMPI 482 Query: 727 PANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKDQTRVVDDNG 786 L +++ISG QLP S ++G D V +E+ G+P D K QTRV+ N Sbjct: 483 ------TLTIRLISGIQLPLTHSS--SNKG---DSLVIIEVFGVPNDQMKQQTRVIKKNA 531 Query: 787 FNPVWEETLTFTVHMPEIALVRFLVWDHDPI-GRDFVGQRTVTFSSLVPGYRHVYL---- 841 F+P W ET TF +H+PE+AL+RF+V I G +F+GQ T+ + GYR + L Sbjct: 532 FSPRWNETFTFIIHVPELALIRFVVEGQGLIAGNEFLGQYTLPLLCMNKGYRRIPLFSRM 591 Query: 842 -EGLTEASIFVHI 853 E L AS+FV++ Sbjct: 592 GESLEPASLFVYV 604 >gi|33598948 phospholipase C, gamma 1 isoform a [Homo sapiens] Length = 1291 Score = 239 bits (609), Expect = 2e-62 Identities = 165/502 (32%), Positives = 259/502 (51%), Gaps = 46/502 (9%) Query: 13 EKVERCMSVMQSGTQMIKL--KRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIY 70 E + C S ++ GT M K+ + + F + ++ W + I I I Sbjct: 21 EVLHLCRS-LEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIREIK 79 Query: 71 KVTEGRQSEIFHRQAEGNF---DPSCCFTIYHGNH--MESLDLITSNPEEARTWITGLKY 125 ++ G+ S F R E D S CF I +G +++L L ++ +E WI GL + Sbjct: 80 EIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTW 139 Query: 126 LMAGISDEDSL-AKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPR-RKV 183 LM ED+L A ++W+++ F D+N + ++ +++ ++ ++N +P R + Sbjct: 140 LM-----EDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFL 194 Query: 184 RQMFQEADTDENQGTLTFEEFCVFYK--MMSLRRDLYLLLLSYSDKKD-------HLTVE 234 R+ D ++ G +T+ +F Y+ M S ++ + L L S + +++ Sbjct: 195 RERL--TDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLP 252 Query: 235 ELAQFLKVEQ---------KMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSP 285 E QFL Q ++ + D +++ E + ++ F F+ S Sbjct: 253 EFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIE-------EPYFFLDEFVTFLFSK 305 Query: 286 ACDIFNPLHHEVYQD-MDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVE 344 ++N V D M+ PL +Y+I+SSHNTYLTGDQ S+S ++ YAR L+ GCRC+E Sbjct: 306 ENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIE 365 Query: 345 VDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKI 404 +DCWDGPDG PV++HG+TLT+KI F DV+ TI +HAFV +E+PVILSIE+HCSI QQR + Sbjct: 366 LDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNM 425 Query: 405 AQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDS 464 AQY K + GD L V+ LPSP LK KIL+K KKL G EE S S Sbjct: 426 AQYFKKVLGDTLLTKPVEI-SADGLPSPNQLKRKILIKHKKLAE--GSAYEEVPTSMMYS 482 Query: 465 ADEIEDECKFKLHYSNGTTEHQ 486 ++I + K + Y H+ Sbjct: 483 ENDISNSIKNGILYLEDPVNHE 504 Score = 172 bits (435), Expect = 3e-42 Identities = 108/280 (38%), Positives = 155/280 (55%), Gaps = 20/280 (7%) Query: 587 RLGRRRKTMKLCRELSDLVVYTNSVAAQDI---VDDGTTGNVLSFSETRAHQVVQQ-KSE 642 ++ RRK K+ ELS+LVVY V + + ++ SF ET+A + V + K + Sbjct: 941 KIMERRK--KIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGK 998 Query: 643 QFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANG 702 +F+ YN+ QL+RIYP R+DSSN++PLP W G QLVALN+Q+ + MQ+N+A F Sbjct: 999 KFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGR 1058 Query: 703 NCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPF 762 +CGYVL+P M F+PF L + ++V+ + LPK RG I+ PF Sbjct: 1059 HCGYVLQPSTMRDEAFDPFDKSSLRGLEPCAISIEVLGARHLPK------NGRG-IVCPF 1111 Query: 763 VEVEIIGLPVDCCKDQTRVVDDNGFNPVW-EETLTFTVHMPEIALVRFLVWDHDPIG-RD 820 VE+E+ G D K +T V DNG NPVW + F + PE A +RF+V++ D ++ Sbjct: 1112 VEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQN 1171 Query: 821 FVGQRTVTFSSLVPGYRHV-----YLEGLTEASIFVHITI 855 F+ Q T L GYR V Y E L AS+ + I I Sbjct: 1172 FLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDI 1211 >gi|33598946 phospholipase C, gamma 1 isoform b [Homo sapiens] Length = 1290 Score = 239 bits (609), Expect = 2e-62 Identities = 165/502 (32%), Positives = 259/502 (51%), Gaps = 46/502 (9%) Query: 13 EKVERCMSVMQSGTQMIKL--KRGTKGLVRLFYLDEHRTRLRWRPSRKSEKAKILIDSIY 70 E + C S ++ GT M K+ + + F + ++ W + I I I Sbjct: 21 EVLHLCRS-LEVGTVMTLFYSKKSQRPERKTFQVKLETRQITWSRGADKIEGAIDIREIK 79 Query: 71 KVTEGRQSEIFHRQAEGNF---DPSCCFTIYHGNH--MESLDLITSNPEEARTWITGLKY 125 ++ G+ S F R E D S CF I +G +++L L ++ +E WI GL + Sbjct: 80 EIRPGKTSRDFDRYQEDPAFRPDQSHCFVILYGMEFRLKTLSLQATSEDEVNMWIKGLTW 139 Query: 126 LMAGISDEDSL-AKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPR-RKV 183 LM ED+L A ++W+++ F D+N + ++ +++ ++ ++N +P R + Sbjct: 140 LM-----EDTLQAPTPLQIERWLRKQFYSVDRNREDRISAKDLKNMLSQVNYRVPNMRFL 194 Query: 184 RQMFQEADTDENQGTLTFEEFCVFYK--MMSLRRDLYLLLLSYSDKKD-------HLTVE 234 R+ D ++ G +T+ +F Y+ M S ++ + L L S + +++ Sbjct: 195 RERL--TDLEQRSGDITYGQFAQLYRSLMYSAQKTMDLPFLEASTLRAGERPELCRVSLP 252 Query: 235 ELAQFLKVEQ---------KMNNVTTDYCLDIIKKFEVSEENKVKNVLGIEGFTNFMRSP 285 E QFL Q ++ + D +++ E + ++ F F+ S Sbjct: 253 EFQQFLLDYQGELWAVDRLQVQEFMLSFLRDPLREIE-------EPYFFLDEFVTFLFSK 305 Query: 286 ACDIFNPLHHEVYQD-MDQPLCNYYIASSHNTYLTGDQLLSQSKVDMYARVLQEGCRCVE 344 ++N V D M+ PL +Y+I+SSHNTYLTGDQ S+S ++ YAR L+ GCRC+E Sbjct: 306 ENSVWNSQLDAVCPDTMNNPLSHYWISSSHNTYLTGDQFSSESSLEAYARCLRMGCRCIE 365 Query: 345 VDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKNEFPVILSIENHCSIQQQRKI 404 +DCWDGPDG PV++HG+TLT+KI F DV+ TI +HAFV +E+PVILSIE+HCSI QQR + Sbjct: 366 LDCWDGPDGMPVIYHGHTLTTKIKFSDVLHTIKEHAFVASEYPVILSIEDHCSIAQQRNM 425 Query: 405 AQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKILVKGKKLPYHLGDDAEEGEVSDEDS 464 AQY K + GD L V+ LPSP LK KIL+K KKL G EE S S Sbjct: 426 AQYFKKVLGDTLLTKPVEI-SADGLPSPNQLKRKILIKHKKLAE--GSAYEEVPTSMMYS 482 Query: 465 ADEIEDECKFKLHYSNGTTEHQ 486 ++I + K + Y H+ Sbjct: 483 ENDISNSIKNGILYLEDPVNHE 504 Score = 172 bits (435), Expect = 3e-42 Identities = 108/280 (38%), Positives = 155/280 (55%), Gaps = 20/280 (7%) Query: 587 RLGRRRKTMKLCRELSDLVVYTNSVAAQDI---VDDGTTGNVLSFSETRAHQVVQQ-KSE 642 ++ RRK K+ ELS+LVVY V + + ++ SF ET+A + V + K + Sbjct: 941 KIMERRK--KIALELSELVVYCRPVPFDEEKIGTERACYRDMSSFPETKAEKYVNKAKGK 998 Query: 643 QFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANG 702 +F+ YN+ QL+RIYP R+DSSN++PLP W G QLVALN+Q+ + MQ+N+A F Sbjct: 999 KFLQYNRLQLSRIYPKGQRLDSSNYDPLPMWICGSQLVALNFQTPDKPMQMNQALFMTGR 1058 Query: 703 NCGYVLKPQQMCKGTFNPFSGDPLPANPKKQLILKVISGQQLPKPPDSMFGDRGEIIDPF 762 +CGYVL+P M F+PF L + ++V+ + LPK RG I+ PF Sbjct: 1059 HCGYVLQPSTMRDEAFDPFDKSSLRGLEPCAISIEVLGARHLPK------NGRG-IVCPF 1111 Query: 763 VEVEIIGLPVDCCKDQTRVVDDNGFNPVW-EETLTFTVHMPEIALVRFLVWDHDPIG-RD 820 VE+E+ G D K +T V DNG NPVW + F + PE A +RF+V++ D ++ Sbjct: 1112 VEIEVAGAEYDSTKQKTEFVVDNGLNPVWPAKPFHFQISNPEFAFLRFVVYEEDMFSDQN 1171 Query: 821 FVGQRTVTFSSLVPGYRHV-----YLEGLTEASIFVHITI 855 F+ Q T L GYR V Y E L AS+ + I I Sbjct: 1172 FLAQATFPVKGLKTGYRAVPLKNNYSEDLELASLLIKIDI 1211 >gi|117320537 phospholipase C, gamma 2 [Homo sapiens] Length = 1265 Score = 235 bits (599), Expect = 3e-61 Identities = 150/443 (33%), Positives = 233/443 (52%), Gaps = 54/443 (12%) Query: 56 SRKSEKAKILID--SIYKVTEGRQSEIFHRQAEGNFDPSCCFTIYHGNH--MESLDLITS 111 S+ ++K + +D I ++ G+ S+ F R CCFTI +G + +L L Sbjct: 55 SKTADKIEGFLDIMEIKEIRPGKNSKDFERAKAVRQKEDCCFTILYGTQFVLSTLSLAAD 114 Query: 112 NPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLM 171 + E+A W++GLK L E A + W+++ D+ +++ E+ ++ Sbjct: 115 SKEDAVNWLSGLKIL----HQEAMNASTPTIIESWLRKQIYSVDQTRRNSISLRELKTIL 170 Query: 172 HKLNVNLPRRK-VRQMFQEADTDENQGTLTFEEFCVFYKMM----------SLRRDLYLL 220 +N + K ++ F E +++ L+FE+F +FYK + ++D + Sbjct: 171 PLINFKVSSAKFLKDKFVEIGAHKDE--LSFEQFHLFYKKLMFEQQKSILDEFKKDSSVF 228 Query: 221 LLSYSDKKD--------------HLTVEELAQFL-KVEQKMNNVTTDYCLDIIKKFEVSE 265 +L +D+ D H E AQ L KV ++M D + + F Sbjct: 229 ILGNTDRPDASAVYLHDFQRFLIHEQQEHWAQDLNKVRERMTKFIDDTMRETAEPF---- 284 Query: 266 ENKVKNVLGIEGFTNFMRSPACDIFNPLHHEV-YQDMDQPLCNYYIASSHNTYLTGDQLL 324 L ++ F ++ S I++ + V QDM+ PL +Y+I+SSHNTYLTGDQL Sbjct: 285 -------LFVDEFLTYLFSRENSIWDEKYDAVDMQDMNNPLSHYWISSSHNTYLTGDQLR 337 Query: 325 SQSKVDMYARVLQEGCRCVEVDCWDGPDGEPVVHHGYTLTSKILFRDVVETINKHAFVKN 384 S+S + Y R L+ GCRC+E+DCWDGPDG+PV++HG+T T+KI F DVV+ I HAFV + Sbjct: 338 SESSPEAYIRCLRMGCRCIELDCWDGPDGKPVIYHGWTRTTKIKFDDVVQAIKDHAFVTS 397 Query: 385 EFPVILSIENHCSIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQLPSPQSLKGKILVKGK 444 FPVILSIE HCS++QQR +A+ K +FGD L L+ QLPSP L+ KI++K K Sbjct: 398 SFPVILSIEEHCSVEQQRHMAKAFKEVFGDLL-LTKPTEASADQLPSPSQLREKIIIKHK 456 Query: 445 KLPYHLGDDAEEGEVSDEDSADE 467 KL + +V+ ED DE Sbjct: 457 KL-----GPRGDVDVNMEDKKDE 474 Score = 169 bits (427), Expect = 3e-41 Identities = 100/273 (36%), Positives = 153/273 (56%), Gaps = 26/273 (9%) Query: 593 KTMKLCRELSDLVVYTNSVA-AQDIVDDGTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQ 651 K + ELSDLVVY + +D +++ + SF ET+A +++QK + YNQK Sbjct: 922 KNQSIAIELSDLVVYCKPTSKTKDNLENPDFREIRSFVETKADSIIRQKPVDLLKYNQKG 981 Query: 652 LTRIYPSAYRIDSSNFNPLPYWNAGCQLVALNYQSEGRMMQLNRAKFKANGNCGYVLKPQ 711 LTR+YP R+DSSN++P W G Q+VALN+Q+ + MQ+N A F NG GYVL+P+ Sbjct: 982 LTRVYPKGQRVDSSNYDPFRLWLCGSQMVALNFQTADKYMQMNHALFSLNGRTGYVLQPE 1041 Query: 712 QMCKGTFNPFSGDPLPANPKKQLIL----KVISGQQLPKPPDSMFGDRGEIIDPFVEVEI 767 M + DP+P ++++++ KV+ + LPK S I PFVEVEI Sbjct: 1042 SMRTEKY-----DPMPPESQRKILMTLTVKVLGARHLPKLGRS-------IACPFVEVEI 1089 Query: 768 IGLPVDCCKDQTRVVDDNGFNPVW---EETLTFTVHMPEIALVRFLVWDHDPIG-RDFVG 823 G D K +T VV+DNG +P+W +E +TF ++ P +A +RF+V++ D +F+ Sbjct: 1090 CGAEYDNNKFKTTVVNDNGLSPIWAPTQEKVTFEIYDPNLAFLRFVVYEEDMFSDPNFLA 1149 Query: 824 QRTVTFSSLVPGYRHV-----YLEGLTEASIFV 851 T ++ G+R V Y E + AS+ V Sbjct: 1150 HATYPIKAVKSGFRSVPLKNGYSEDIELASLLV 1182 >gi|12083581 phosphoinositide-specific phospholipase C beta 1 isoform a [Homo sapiens] Length = 1216 Score = 174 bits (441), Expect = 7e-43 Identities = 119/411 (28%), Positives = 212/411 (51%), Gaps = 35/411 (8%) Query: 102 HMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEA--DKNGD 159 ++ L+L+ E A+ W + L +L + + D ++++ + + + Sbjct: 113 NISHLNLVAFQEEVAKEWTNEVFSLAT------NLLAQNMSRDAFLEKAYTKLKLQVTPE 166 Query: 160 GLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDEN------QGTLTFEEFCVFYKMMSL 213 G + ++ I++L + R++V + + Q T E + VF + Sbjct: 167 GRIPLKNIYRLF-----SADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCP 221 Query: 214 RRDLYLLLLSYSDK-KDHLTVEELAQFLKVEQK---MNNVT-----TDYCLDIIKKFEVS 264 R ++ + + K K +LTV+++ F+ ++Q+ +N + + +I+K+E + Sbjct: 222 RPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPN 281 Query: 265 EENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLL 324 K + ++GF ++ + +P ++ +DM QPL +Y+I SSHNTYLT QL Sbjct: 282 NSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLA 341 Query: 325 SQSKVDMYARVLQEGCRCVEVDCWDG--PDGEPVVHHGYTLTSKILFRDVVETINKHAFV 382 S V+MY +VL GCRCVE+DCW G + EPV+ HG+T+T++I F++V+E I + AF Sbjct: 342 GNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFK 401 Query: 383 KNEFPVILSIENHC-SIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQ---LPSPQSLKGK 438 + FP++LS ENH S +QQ K+A+Y + IFGD L + ++ + LPSP L K Sbjct: 402 TSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYK 461 Query: 439 ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVES 489 ILVK KK + + + + ++S++ S + F+ S G E ES Sbjct: 462 ILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFE-PSSPGAGEADTES 511 Score = 145 bits (366), Expect = 3e-34 Identities = 99/309 (32%), Positives = 161/309 (52%), Gaps = 34/309 (11%) Query: 563 SKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDD--- 619 ++S DD++D ++S+ EG E+S+LV Y V + Sbjct: 509 TESDDDDDDDDCKKSSMDEG-------TAGSEAMATEEMSNLVNYIQPVKFESFEISKKR 561 Query: 620 GTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQL 679 + + SF ET+ + + + +F+ YN+ QL+RIYP R+DSSN+ P +WNAGCQ+ Sbjct: 562 NKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQM 621 Query: 680 VALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT--FNPFSGDPLPANPKKQLILK 737 VALN+Q+ MQ+N ++ NG GY LKP+ M + F+PF+ + L +K Sbjct: 622 VALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVK 681 Query: 738 VISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKD--QTRVVDDNGFNPVW-EET 794 +ISGQ L + + +VEV++ GLPVD + +T+ N NPVW EE Sbjct: 682 IISGQFL----------SDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEP 731 Query: 795 LTF-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYL-----EGLTEAS 848 + F V +P +A +R V++ G F+G R + ++ PGY ++ L + LT + Sbjct: 732 IVFKKVVLPTLACLRIAVYEE---GGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPA 788 Query: 849 IFVHITINE 857 +FV+I + + Sbjct: 789 VFVYIEVKD 797 >gi|33356544 phosphoinositide-specific phospholipase C beta 1 isoform b [Homo sapiens] Length = 1173 Score = 174 bits (441), Expect = 7e-43 Identities = 119/411 (28%), Positives = 212/411 (51%), Gaps = 35/411 (8%) Query: 102 HMESLDLITSNPEEARTWITGLKYLMAGISDEDSLAKRQRTHDQWVKQTFEEA--DKNGD 159 ++ L+L+ E A+ W + L +L + + D ++++ + + + Sbjct: 113 NISHLNLVAFQEEVAKEWTNEVFSLAT------NLLAQNMSRDAFLEKAYTKLKLQVTPE 166 Query: 160 GLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDEN------QGTLTFEEFCVFYKMMSL 213 G + ++ I++L + R++V + + Q T E + VF + Sbjct: 167 GRIPLKNIYRLF-----SADRKRVETALEACSLPSSRNDSIPQEDFTPEVYRVFLNNLCP 221 Query: 214 RRDLYLLLLSYSDK-KDHLTVEELAQFLKVEQK---MNNVT-----TDYCLDIIKKFEVS 264 R ++ + + K K +LTV+++ F+ ++Q+ +N + + +I+K+E + Sbjct: 222 RPEIDNIFSEFGAKSKPYLTVDQMMDFINLKQRDPRLNEILYPPLKQEQVQVLIEKYEPN 281 Query: 265 EENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYLTGDQLL 324 K + ++GF ++ + +P ++ +DM QPL +Y+I SSHNTYLT QL Sbjct: 282 NSLARKGQISVDGFMRYLSGEENGVVSPEKLDLNEDMSQPLSHYFINSSHNTYLTAGQLA 341 Query: 325 SQSKVDMYARVLQEGCRCVEVDCWDG--PDGEPVVHHGYTLTSKILFRDVVETINKHAFV 382 S V+MY +VL GCRCVE+DCW G + EPV+ HG+T+T++I F++V+E I + AF Sbjct: 342 GNSSVEMYRQVLLSGCRCVELDCWKGRTAEEEPVITHGFTMTTEISFKEVIEAIAECAFK 401 Query: 383 KNEFPVILSIENHC-SIQQQRKIAQYLKGIFGDKLDLSSVDTGECKQ---LPSPQSLKGK 438 + FP++LS ENH S +QQ K+A+Y + IFGD L + ++ + LPSP L K Sbjct: 402 TSPFPILLSFENHVDSPKQQAKMAEYCRLIFGDALLMEPLEKYPLESGVPLPSPMDLMYK 461 Query: 439 ILVKGKKLPYHLGDDAEEGEVSDEDSADEIEDECKFKLHYSNGTTEHQVES 489 ILVK KK + + + + ++S++ S + F+ S G E ES Sbjct: 462 ILVKNKKKSHKSSEGSGKKKLSEQASNTYSDSSSMFE-PSSPGAGEADTES 511 Score = 145 bits (366), Expect = 3e-34 Identities = 99/309 (32%), Positives = 161/309 (52%), Gaps = 34/309 (11%) Query: 563 SKSYSTDDEEDTQQSTGKEGGQLYRLGRRRKTMKLCRELSDLVVYTNSVAAQDIVDD--- 619 ++S DD++D ++S+ EG E+S+LV Y V + Sbjct: 509 TESDDDDDDDDCKKSSMDEG-------TAGSEAMATEEMSNLVNYIQPVKFESFEISKKR 561 Query: 620 GTTGNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQL 679 + + SF ET+ + + + +F+ YN+ QL+RIYP R+DSSN+ P +WNAGCQ+ Sbjct: 562 NKSFEMSSFVETKGLEQLTKSPVEFVEYNKMQLSRIYPKGTRVDSSNYMPQLFWNAGCQM 621 Query: 680 VALNYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCKGT--FNPFSGDPLPANPKKQLILK 737 VALN+Q+ MQ+N ++ NG GY LKP+ M + F+PF+ + L +K Sbjct: 622 VALNFQTMDLAMQINMGMYEYNGKSGYRLKPEFMRRPDKHFDPFTEGIVDGIVANTLSVK 681 Query: 738 VISGQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKD--QTRVVDDNGFNPVW-EET 794 +ISGQ L + + +VEV++ GLPVD + +T+ N NPVW EE Sbjct: 682 IISGQFL----------SDKKVGTYVEVDMFGLPVDTRRKAFKTKTSQGNAVNPVWEEEP 731 Query: 795 LTF-TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYL-----EGLTEAS 848 + F V +P +A +R V++ G F+G R + ++ PGY ++ L + LT + Sbjct: 732 IVFKKVVLPTLACLRIAVYEE---GGKFIGHRILPVQAIRPGYHYICLRNERNQPLTLPA 788 Query: 849 IFVHITINE 857 +FV+I + + Sbjct: 789 VFVYIEVKD 797 >gi|95147333 phospholipase C, beta 2 [Homo sapiens] Length = 1185 Score = 169 bits (428), Expect = 2e-41 Identities = 100/253 (39%), Positives = 146/253 (57%), Gaps = 17/253 (6%) Query: 210 MMSL--RRDLYLLLLSYSDK-KDHLTVEELAQFLKVEQKMNNVTT--------DYCLDII 258 +MSL R ++ + SY K K ++T E L +F+ +Q+ + + + D +I Sbjct: 212 LMSLCPRPEIDEIFTSYHAKAKPYMTKEHLTKFINQKQRDSRLNSLLFPPARPDQVQGLI 271 Query: 259 KKFEVSEENKVKNVLGIEGFTNFMRSPACDIFNPLHHEVYQDMDQPLCNYYIASSHNTYL 318 K+E S N + L EG F+ P + ++ DM QPL +Y+I SSHNTYL Sbjct: 272 DKYEPSGINAQRGQLSPEGMVWFLCGPENSVLAQDKLLLHHDMTQPLNHYFINSSHNTYL 331 Query: 319 TGDQLLSQSKVDMYARVLQEGCRCVEVDCWDG--PDGEPVVHHGYTLTSKILFRDVVETI 376 T Q S +MY +VL GCRCVE+DCW G PD EP++ HG+T+T+ I F++ +E I Sbjct: 332 TAGQFSGLSSAEMYRQVLLSGCRCVELDCWKGKPPDEEPIITHGFTMTTDIFFKEAIEAI 391 Query: 377 NKHAFVKNEFPVILSIENHC-SIQQQRKIAQYLKGIFGDKLDLSSVDTGECK---QLPSP 432 + AF + +P+ILS ENH S +QQ K+A+Y + IFGD L ++ K LPSP Sbjct: 392 AESAFKTSPYPIILSFENHVDSPRQQAKMAEYCRTIFGDMLLTEPLEKFPLKPGVPLPSP 451 Query: 433 QSLKGKILVKGKK 445 + L+GKIL+K KK Sbjct: 452 EDLRGKILIKNKK 464 Score = 152 bits (383), Expect = 3e-36 Identities = 125/413 (30%), Positives = 204/413 (49%), Gaps = 39/413 (9%) Query: 570 DEEDTQQSTGKEGGQLYRLGRRRKTMKL----CRELSDLVVY---TNSVAAQDIVDDGTT 622 +EE+ ++S + ++ ++ T L E+S LV Y T V+ + + Sbjct: 511 EEEEEEESGNLDEEEIKKMQSDEGTAGLEVTAYEEMSSLVNYIQPTKFVSFEFSAQKNRS 570 Query: 623 GNVLSFSETRAHQVVQQKSEQFMIYNQKQLTRIYPSAYRIDSSNFNPLPYWNAGCQLVAL 682 + SF+E +A+ ++ + S QF+ YN++Q++RIYP R+DSSN+ P +WNAGCQ+VAL Sbjct: 571 YVISSFTELKAYDLLSKASVQFVDYNKRQMSRIYPKGTRMDSSNYMPQMFWNAGCQMVAL 630 Query: 683 NYQSEGRMMQLNRAKFKANGNCGYVLKPQQMCK--GTFNPFSGDPLPANPKKQLILKVIS 740 N+Q+ MQ N A F+ NG GY+LK + M + FNPFS D + L + VIS Sbjct: 631 NFQTMDLPMQQNMAVFEFNGQSGYLLKHEFMRRPDKQFNPFSVDRIDVVVATTLSITVIS 690 Query: 741 GQQLPKPPDSMFGDRGEIIDPFVEVEIIGLPVDCCKD-QTRV-VDDNGFNPVW-EETLTF 797 GQ L + + +VEVE+ GLP D + +T++ N NPVW EE F Sbjct: 691 GQFLSE----------RSVRTYVEVELFGLPGDPKRRYRTKLSPSTNSINPVWKEEPFVF 740 Query: 798 -TVHMPEIALVRFLVWDHDPIGRDFVGQRTVTFSSLVPGYRHVYLEG-----LTEASIFV 851 + MPE+A +R V + G F+G R + ++L GY H+ L LT ++F+ Sbjct: 741 EKILMPELASLRVAVMEE---GNKFLGHRIIPINALNSGYHHLCLHSESNMPLTMPALFI 797 Query: 852 HITINE-IYGKWSPLILNPSYTILHFLG-ATKNRQLQGLKGLFNKNPRHSSSENNSHYVR 909 + + + I G W+ L + + I F TK+ +L+ G + P +S S Sbjct: 798 FLEMKDYIPGAWADLTVALANPIKFFSAHDTKSVKLKEAMGGLPEKPFPLASPVAS---- 853 Query: 910 KRSIGDRILRRTASAPAKGRKKSKMGFQEMVEIKDSVSEATRDQDGVLRRTTR 962 + + + +PA + +E E + + E R+ GV++ R Sbjct: 854 --QVNGALAPTSNGSPAARAGAREEAMKEAAEPRTASLEELRELKGVVKLQRR 904 >gi|209862851 plastin 3 [Homo sapiens] Length = 630 Score = 45.1 bits (105), Expect = 6e-04 Identities = 26/81 (32%), Positives = 47/81 (58%), Gaps = 5/81 (6%) Query: 134 DSLAKRQRTHDQW--VKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQE-- 189 D +A Q + D+ +K+ F + D N +G + E+H+L + N+ LP KVR++ Q+ Sbjct: 2 DEMATTQISKDELDELKEAFAKVDLNSNGFICDYELHELFKEANMPLPGYKVREIIQKLM 61 Query: 190 ADTDENQ-GTLTFEEFCVFYK 209 D D N+ G ++F+EF ++ Sbjct: 62 LDGDRNKDGKISFDEFVYIFQ 82 >gi|7549809 plastin 3 [Homo sapiens] Length = 630 Score = 45.1 bits (105), Expect = 6e-04 Identities = 26/81 (32%), Positives = 47/81 (58%), Gaps = 5/81 (6%) Query: 134 DSLAKRQRTHDQW--VKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQE-- 189 D +A Q + D+ +K+ F + D N +G + E+H+L + N+ LP KVR++ Q+ Sbjct: 2 DEMATTQISKDELDELKEAFAKVDLNSNGFICDYELHELFKEANMPLPGYKVREIIQKLM 61 Query: 190 ADTDENQ-GTLTFEEFCVFYK 209 D D N+ G ++F+EF ++ Sbjct: 62 LDGDRNKDGKISFDEFVYIFQ 82 >gi|11067753 calcium binding protein 5 [Homo sapiens] Length = 173 Score = 44.7 bits (104), Expect = 8e-04 Identities = 27/69 (39%), Positives = 41/69 (59%), Gaps = 5/69 (7%) Query: 145 QWVKQTFEEADKNGDGLLNIEEIHQLMHK-LNVNLPRRKVRQMFQEADTDENQGTLTFEE 203 Q ++ F+E D NGDG + + E+ Q M + L L R++ ++ +EAD + GT+ FEE Sbjct: 108 QEMRDAFKEFDTNGDGEITLVELQQAMQRLLGERLTPREISEVVREADVN-GDGTVDFEE 166 Query: 204 FCVFYKMMS 212 F KMMS Sbjct: 167 ---FVKMMS 172 >gi|223278387 calmodulin-like 5 [Homo sapiens] Length = 146 Score = 44.3 bits (103), Expect = 0.001 Identities = 26/91 (28%), Positives = 46/91 (50%), Gaps = 3/91 (3%) Query: 148 KQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEFCVF 207 K+ F D +G+G +N +E+ + NL ++R++ E D+D G ++F+EF Sbjct: 14 KKAFSAVDTDGNGTINAQELGAALKATGKNLSEAQLRKLISEVDSD-GDGEISFQEFLTA 72 Query: 208 YKMMSL-RRDLYLLLLSYSDKKD-HLTVEEL 236 K DL + ++ D H+TV+EL Sbjct: 73 AKKARAGLEDLQVAFRAFDQDGDGHITVDEL 103 Score = 43.9 bits (102), Expect = 0.001 Identities = 22/68 (32%), Positives = 41/68 (60%), Gaps = 1/68 (1%) Query: 137 AKRQRTHDQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQ 196 AK+ R + ++ F D++GDG + ++E+ + M L LP+ ++ M +EAD D++ Sbjct: 73 AKKARAGLEDLQVAFRAFDQDGDGHITVDELRRAMAGLGQPLPQEELDAMIREADVDQD- 131 Query: 197 GTLTFEEF 204 G + +EEF Sbjct: 132 GRVNYEEF 139 >gi|4885111 calmodulin-like 3 [Homo sapiens] Length = 149 Score = 43.5 bits (101), Expect = 0.002 Identities = 39/148 (26%), Positives = 71/148 (47%), Gaps = 28/148 (18%) Query: 71 KVTEGRQS-EIFHRQAEGNFDPSCCFTIYHGNHMESLDLITSNPEEARTWITGLKYLMAG 129 +VTE +++ +F + +G C T G M SL NP EA L+ +M+ Sbjct: 9 QVTEFKEAFSLFDKDGDG-----CITTRELGTVMRSLG---QNPTEAE-----LRDMMSE 55 Query: 130 ISDEDS-----------LAKRQRTHD--QWVKQTFEEADKNGDGLLNIEEIHQLMHKLNV 176 I + + +A++ + D + +++ F DK+G+G ++ E+ +M +L Sbjct: 56 IDRDGNGTVDFPEFLGMMARKMKDTDNEEEIREAFRVFDKDGNGFVSAAELRHVMTRLGE 115 Query: 177 NLPRRKVRQMFQEADTDENQGTLTFEEF 204 L +V +M + ADTD G + +EEF Sbjct: 116 KLSDEEVDEMIRAADTD-GDGQVNYEEF 142 >gi|58218968 calmodulin 3 [Homo sapiens] Length = 149 Score = 42.0 bits (97), Expect = 0.005 Identities = 21/57 (36%), Positives = 31/57 (54%), Gaps = 1/57 (1%) Query: 148 KQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEF 204 K+ F DK+GDG + +E+ +M L N +++ M E D D N GT+ F EF Sbjct: 14 KEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGN-GTIDFPEF 69 Score = 40.4 bits (93), Expect = 0.015 Identities = 19/61 (31%), Positives = 35/61 (57%), Gaps = 1/61 (1%) Query: 144 DQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEE 203 ++ +++ F DK+G+G ++ E+ +M L L +V +M +EAD D G + +EE Sbjct: 83 EEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADID-GDGQVNYEE 141 Query: 204 F 204 F Sbjct: 142 F 142 >gi|4502549 calmodulin 2 [Homo sapiens] Length = 149 Score = 42.0 bits (97), Expect = 0.005 Identities = 21/57 (36%), Positives = 31/57 (54%), Gaps = 1/57 (1%) Query: 148 KQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEEF 204 K+ F DK+GDG + +E+ +M L N +++ M E D D N GT+ F EF Sbjct: 14 KEAFSLFDKDGDGTITTKELGTVMRSLGQNPTEAELQDMINEVDADGN-GTIDFPEF 69 Score = 40.4 bits (93), Expect = 0.015 Identities = 19/61 (31%), Positives = 35/61 (57%), Gaps = 1/61 (1%) Query: 144 DQWVKQTFEEADKNGDGLLNIEEIHQLMHKLNVNLPRRKVRQMFQEADTDENQGTLTFEE 203 ++ +++ F DK+G+G ++ E+ +M L L +V +M +EAD D G + +EE Sbjct: 83 EEEIREAFRVFDKDGNGYISAAELRHVMTNLGEKLTDEEVDEMIREADID-GDGQVNYEE 141 Query: 204 F 204 F Sbjct: 142 F 142 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.314 0.131 0.381 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 65,872,156 Number of Sequences: 37866 Number of extensions: 3167533 Number of successful extensions: 9078 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 46 Number of HSP's successfully gapped in prelim test: 156 Number of HSP's that attempted gapping in prelim test: 8655 Number of HSP's gapped (non-prelim): 494 length of query: 1693 length of database: 18,247,518 effective HSP length: 116 effective length of query: 1577 effective length of database: 13,855,062 effective search space: 21849432774 effective search space used: 21849432774 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (22.0 bits) S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.