Search of human proteins with 195972859

Search of human proteins with 195972859

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]
         (399 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]                     814   0.0  
gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]                       809   0.0  
gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]                     691   0.0  
gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]                       686   0.0  
gi|4758968 cytohesin 3 [Homo sapiens]                                 671   0.0  
gi|7019505 cytohesin 4 [Homo sapiens]                                 583   e-166
gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange pr...   187   1e-47
gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange...   179   5e-45
gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]      167   1e-41
gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]       167   1e-41
gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]                 160   2e-39
gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]       153   3e-37
gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]       153   3e-37
gi|4758416 golgi-specific brefeldin A resistant guanine nucleoti...   144   1e-34
gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]    111   1e-24
gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]      110   3e-24
gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6 ...   109   5e-24
gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6...   109   5e-24
gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]    107   1e-23
gi|48928044 F-box only protein 8 [Homo sapiens]                        93   4e-19
gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo sa...    66   5e-11
gi|158631203 dual adaptor of phosphotyrosine and 3-phosphoinosit...    57   3e-08
gi|239047795 pleckstrin homology domain containing, family A mem...    57   4e-08
gi|145312241 differentially expressed in FDCP 6 homolog [Homo sa...    56   7e-08
gi|24432056 hypothetical protein LOC144717 [Homo sapiens]              55   1e-07
gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]             54   2e-07
gi|93102364 SWAP-70 protein [Homo sapiens]                             54   3e-07
gi|50234893 pleckstrin homology domain containing, family A (pho...    54   3e-07
gi|31377720 pleckstrin homology domain containing, family A (pho...    54   3e-07
gi|55741447 pleckstrin homology domain containing, family H (wit...    52   9e-07

>gi|195972859 cytohesin 2 isoform 2 [Homo sapiens]
          Length = 399

 Score =  814 bits (2102), Expect = 0.0
 Identities = 399/399 (100%), Positives = 399/399 (100%)

Query: 1   MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQ 60
           MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQ
Sbjct: 1   MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQ 60

Query: 61  RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREE 120
           RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREE
Sbjct: 61  RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREE 120

Query: 121 LNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQ 180
           LNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQ
Sbjct: 121 LNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQ 180

Query: 181 STDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRN 240
           STDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRN
Sbjct: 181 STDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRN 240

Query: 241 EPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPR 300
           EPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPR
Sbjct: 241 EPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPR 300

Query: 301 GIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQ 360
           GIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQ
Sbjct: 301 GIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQ 360

Query: 361 EEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP 399
           EEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP
Sbjct: 361 EEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP 399


>gi|8670546 cytohesin 2 isoform 1 [Homo sapiens]
          Length = 400

 Score =  809 bits (2090), Expect = 0.0
 Identities = 399/400 (99%), Positives = 399/400 (99%), Gaps = 1/400 (0%)

Query: 1   MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQ 60
           MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQ
Sbjct: 1   MEDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQ 60

Query: 61  RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREE 120
           RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREE
Sbjct: 61  RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREE 120

Query: 121 LNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQ 180
           LNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQ
Sbjct: 121 LNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQ 180

Query: 181 STDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRN 240
           STDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRN
Sbjct: 181 STDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRN 240

Query: 241 EPFKIPEDDGNDLTHTFFNPDREGWLLKL-GGRVKTWKRRWFILTDNCLYYFEYTTDKEP 299
           EPFKIPEDDGNDLTHTFFNPDREGWLLKL GGRVKTWKRRWFILTDNCLYYFEYTTDKEP
Sbjct: 241 EPFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEP 300

Query: 300 RGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPT 359
           RGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPT
Sbjct: 301 RGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPT 360

Query: 360 QEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP 399
           QEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP
Sbjct: 361 QEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKKQEQP 400


>gi|110349763 cytohesin 1 isoform 2 [Homo sapiens]
          Length = 397

 Score =  691 bits (1783), Expect = 0.0
 Identities = 328/394 (83%), Positives = 365/394 (92%)

Query: 2   EDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQR 61
           ED  Y P DLT EER ELENIRRRKQELL +IQRL++E++E  +E+E L + E  K +QR
Sbjct: 3   EDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQR 62

Query: 62  NRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREEL 121
           N+++AMGRKKFNMDPKKGIQFL+EN+LL+NT E+IA+FLYKGEGLNKTAIGDYLGER+E 
Sbjct: 63  NKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEF 122

Query: 122 NLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQS 181
           N+ VLHAFV+LHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYC CN GVFQS
Sbjct: 123 NIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQS 182

Query: 182 TDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNE 241
           TDTCYVLSFA+IMLNTSLHNPNV+DKP +ERF+AMNRGIN+GGDLPEELLRNLY+SI+NE
Sbjct: 183 TDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNE 242

Query: 242 PFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRG 301
           PFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRG
Sbjct: 243 PFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRG 302

Query: 302 IIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQE 361
           IIPLENLSIREV+D +KPNCFELYIP+NK Q+IKACKTEADGRVVEGNH VYRISAPT E
Sbjct: 303 IIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTPE 362

Query: 362 EKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKK 395
           EK+EWIK I+AA+S DPFYEMLAARKK++S  K+
Sbjct: 363 EKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKR 396


>gi|4758964 cytohesin 1 isoform 1 [Homo sapiens]
          Length = 398

 Score =  686 bits (1771), Expect = 0.0
 Identities = 328/395 (83%), Positives = 365/395 (92%), Gaps = 1/395 (0%)

Query: 2   EDGVYEPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQR 61
           ED  Y P DLT EER ELENIRRRKQELL +IQRL++E++E  +E+E L + E  K +QR
Sbjct: 3   EDDSYVPSDLTAEERQELENIRRRKQELLADIQRLKDEIAEVANEIENLGSTEERKNMQR 62

Query: 62  NRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREEL 121
           N+++AMGRKKFNMDPKKGIQFL+EN+LL+NT E+IA+FLYKGEGLNKTAIGDYLGER+E 
Sbjct: 63  NKQVAMGRKKFNMDPKKGIQFLIENDLLKNTCEDIAQFLYKGEGLNKTAIGDYLGERDEF 122

Query: 122 NLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQS 181
           N+ VLHAFV+LHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYC CN GVFQS
Sbjct: 123 NIQVLHAFVELHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCQCNNGVFQS 182

Query: 182 TDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNE 241
           TDTCYVLSFA+IMLNTSLHNPNV+DKP +ERF+AMNRGIN+GGDLPEELLRNLY+SI+NE
Sbjct: 183 TDTCYVLSFAIIMLNTSLHNPNVKDKPTVERFIAMNRGINDGGDLPEELLRNLYESIKNE 242

Query: 242 PFKIPEDDGNDLTHTFFNPDREGWLLKL-GGRVKTWKRRWFILTDNCLYYFEYTTDKEPR 300
           PFKIPEDDGNDLTHTFFNPDREGWLLKL GGRVKTWKRRWFILTDNCLYYFEYTTDKEPR
Sbjct: 243 PFKIPEDDGNDLTHTFFNPDREGWLLKLGGGRVKTWKRRWFILTDNCLYYFEYTTDKEPR 302

Query: 301 GIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQ 360
           GIIPLENLSIREV+D +KPNCFELYIP+NK Q+IKACKTEADGRVVEGNH VYRISAPT 
Sbjct: 303 GIIPLENLSIREVEDSKKPNCFELYIPDNKDQVIKACKTEADGRVVEGNHTVYRISAPTP 362

Query: 361 EEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKKK 395
           EEK+EWIK I+AA+S DPFYEMLAARKK++S  K+
Sbjct: 363 EEKEEWIKCIKAAISRDPFYEMLAARKKKVSSTKR 397


>gi|4758968 cytohesin 3 [Homo sapiens]
          Length = 399

 Score =  671 bits (1731), Expect = 0.0
 Identities = 321/397 (80%), Positives = 365/397 (91%), Gaps = 4/397 (1%)

Query: 2   EDGVYE----PPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSK 57
           EDG  E    P DL+ EER EL +IRRRK+EL+ +I+RL+ E++E M+E++ L + E SK
Sbjct: 3   EDGGGEGGGVPEDLSLEEREELLDIRRRKKELIDDIERLKYEIAEVMTEIDNLTSVEESK 62

Query: 58  TLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGE 117
           T QRN+++AMGRKKFNMDPKKGIQFL+EN+LLQ++PE++A+FLYKGEGLNKT IGDYLGE
Sbjct: 63  TTQRNKQIAMGRKKFNMDPKKGIQFLIENDLLQSSPEDVAQFLYKGEGLNKTVIGDYLGE 122

Query: 118 REELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPG 177
           R+E N+ VL AFV+LHEF DLNLVQALRQFLWSFRLPGEAQKIDRMMEAFA RYCLCNPG
Sbjct: 123 RDEFNIKVLQAFVELHEFADLNLVQALRQFLWSFRLPGEAQKIDRMMEAFASRYCLCNPG 182

Query: 178 VFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDS 237
           VFQSTDTCYVLSFA+IMLNTSLHN NVRDKP  ERF+AMNRGINEGGDLPEELLRNLY+S
Sbjct: 183 VFQSTDTCYVLSFAIIMLNTSLHNHNVRDKPTAERFIAMNRGINEGGDLPEELLRNLYES 242

Query: 238 IRNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDK 297
           I+NEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDK
Sbjct: 243 IKNEPFKIPEDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDK 302

Query: 298 EPRGIIPLENLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISA 357
           EPRGIIPLENLSIREV+DPRKPNCFELY P++KGQ+IKACKTEADGRVVEGNH+VYRISA
Sbjct: 303 EPRGIIPLENLSIREVEDPRKPNCFELYNPSHKGQVIKACKTEADGRVVEGNHVVYRISA 362

Query: 358 PTQEEKDEWIKSIQAAVSVDPFYEMLAARKKRISVKK 394
           P+ EEK+EW+KSI+A++S DPFY+MLA RK+RI+ KK
Sbjct: 363 PSPEEKEEWMKSIKASISRDPFYDMLATRKRRIANKK 399


>gi|7019505 cytohesin 4 [Homo sapiens]
          Length = 394

 Score =  583 bits (1502), Expect = e-166
 Identities = 270/388 (69%), Positives = 335/388 (86%)

Query: 7   EPPDLTPEERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLEANEGSKTLQRNRKMA 66
           EP +L+  E  EL+ I+  +++LL +IQ+L++E+++  ++++  E+ E S+  Q+ +++ 
Sbjct: 7   EPAELSSGETEELQRIKWHRKQLLEDIQKLKDEIADVFAQIDCFESAEESRMAQKEKELC 66

Query: 67  MGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLAVL 126
           +GRKKFNMDP KGIQ+ +E++LL    ++IARFLYKGEGLNKTAIG YLGER+ +NL VL
Sbjct: 67  IGRKKFNMDPAKGIQYFIEHKLLTPDVQDIARFLYKGEGLNKTAIGTYLGERDPINLQVL 126

Query: 127 HAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCY 186
            AFVD HEF +LNLVQALRQFLWSFRLPGEAQKIDRMMEAFA RYCLCNPGVFQSTDTCY
Sbjct: 127 QAFVDCHEFANLNLVQALRQFLWSFRLPGEAQKIDRMMEAFATRYCLCNPGVFQSTDTCY 186

Query: 187 VLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSIRNEPFKIP 246
           VLSF++IMLNTSLHNPNVRD+P  ERFV+MNRGIN G DLPE+ LRNL+DSI++EPF IP
Sbjct: 187 VLSFSIIMLNTSLHNPNVRDRPPFERFVSMNRGINNGSDLPEDQLRNLFDSIKSEPFSIP 246

Query: 247 EDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLE 306
           EDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFE+TTDKEPRGIIPLE
Sbjct: 247 EDDGNDLTHTFFNPDREGWLLKLGGRVKTWKRRWFILTDNCLYYFEFTTDKEPRGIIPLE 306

Query: 307 NLSIREVDDPRKPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEW 366
           NLS+++VDDP+KP C ELY P+ +GQ IKACKT+ DGRVVEG H  YRISA + EE+D+W
Sbjct: 307 NLSVQKVDDPKKPFCLELYNPSCRGQKIKACKTDGDGRVVEGKHESYRISATSAEERDQW 366

Query: 367 IKSIQAAVSVDPFYEMLAARKKRISVKK 394
           I+SI+A+++  PFY++++ RKK+I+ K+
Sbjct: 367 IESIRASITRVPFYDLVSTRKKKIASKQ 394


>gi|51479145 brefeldin A-inhibited guanine nucleotide-exchange
           protein 1 [Homo sapiens]
          Length = 1849

 Score =  187 bits (475), Expect = 1e-47
 Identities = 93/206 (45%), Positives = 140/206 (67%), Gaps = 3/206 (1%)

Query: 45  SEVEGLEANEGSKTLQRNRKMA-MGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKG 103
           +++ G +  E  + L++ +++   G   FN  PK+GIQ+L E  +L  TPE+IA+FL++ 
Sbjct: 681 TQMSGTDNPEQFEVLKQQKEIIEQGIDLFNKKPKRGIQYLQEQGMLGTTPEDIAQFLHQE 740

Query: 104 EGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRM 163
           E L+ T +G++LG+ ++ N  V++A+VD H+F+  + V ALR FL  FRLPGEAQKIDR+
Sbjct: 741 ERLDSTQVGEFLGDNDKFNKEVMYAYVDQHDFSGKDFVSALRMFLEGFRLPGEAQKIDRL 800

Query: 164 MEAFAQRYCLCNPG--VFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGIN 221
           ME FA RY  CN G  +F S DT YVL++++IML T LH+P V++K   E+++ MNRGIN
Sbjct: 801 MEKFAARYLECNQGQTLFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGIN 860

Query: 222 EGGDLPEELLRNLYDSIRNEPFKIPE 247
           +  DLPEE L  +Y+ I  +   + E
Sbjct: 861 DSKDLPEEYLSAIYNEIAGKKISMKE 886


>gi|150417986 ADP-ribosylation factor guanine nucleotide-exchange
           factor 2 [Homo sapiens]
          Length = 1785

 Score =  179 bits (453), Expect = 5e-45
 Identities = 90/190 (47%), Positives = 127/190 (66%), Gaps = 2/190 (1%)

Query: 60  QRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGERE 119
           Q+   +  G + FN  PK+GIQFL E  +L  + E+IA+FL++ E L+ T +GD+LG+  
Sbjct: 642 QQKEIIEHGIELFNKKPKRGIQFLQEQGMLGTSVEDIAQFLHQEERLDSTQVGDFLGDSA 701

Query: 120 ELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPG-- 177
             N  V++A+VD  +F +   V ALR FL  FRLPGEAQKIDR+ME FA RY  CN G  
Sbjct: 702 RFNKEVMYAYVDQLDFCEKEFVSALRTFLEGFRLPGEAQKIDRLMEKFAARYIECNQGQT 761

Query: 178 VFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDS 237
           +F S DT YVL++++IML T LH+P V++K   E+++ MNRGIN+  DLPEE L ++Y+ 
Sbjct: 762 LFASADTAYVLAYSIIMLTTDLHSPQVKNKMTKEQYIKMNRGINDSKDLPEEYLSSIYEE 821

Query: 238 IRNEPFKIPE 247
           I  +   + E
Sbjct: 822 IEGKKIAMKE 831


>gi|197304786 IQ motif and Sec7 domain 1 isoform a [Homo sapiens]
          Length = 1114

 Score =  167 bits (424), Expect = 1e-41
 Identities = 84/199 (42%), Positives = 132/199 (66%), Gaps = 6/199 (3%)

Query: 56  SKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYL 115
           S  + R R   +G   FN  P+KG+Q+L+E   + +TP  +A FL + +GL++  IG++L
Sbjct: 505 SNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFL 564

Query: 116 GERE-ELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLC 174
           G R+ + N  VL   VD  +F+ + L +ALR+F    R+ GEAQK++R++EAF+QRYC+C
Sbjct: 565 GNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCIC 624

Query: 175 NPGV---FQSTDTCYVLSFAVIMLNTSLHNPNVRD--KPGLERFVAMNRGINEGGDLPEE 229
           NPGV   F++ DT ++L+FA+I+LNT +++PNV+   K  LE F+   RG+++G D+P E
Sbjct: 625 NPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPRE 684

Query: 230 LLRNLYDSIRNEPFKIPED 248
           +L  +Y+ IR    K  ED
Sbjct: 685 MLMGIYERIRKRELKTNED 703


>gi|50582989 IQ motif and Sec7 domain 1 isoform b [Homo sapiens]
          Length = 963

 Score =  167 bits (424), Expect = 1e-41
 Identities = 84/199 (42%), Positives = 132/199 (66%), Gaps = 6/199 (3%)

Query: 56  SKTLQRNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYL 115
           S  + R R   +G   FN  P+KG+Q+L+E   + +TP  +A FL + +GL++  IG++L
Sbjct: 519 SNDVIRKRHYRIGLNLFNKKPEKGVQYLIERGFVPDTPVGVAHFLLQRKGLSRQMIGEFL 578

Query: 116 GERE-ELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLC 174
           G R+ + N  VL   VD  +F+ + L +ALR+F    R+ GEAQK++R++EAF+QRYC+C
Sbjct: 579 GNRQKQFNRDVLDCVVDEMDFSTMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCIC 638

Query: 175 NPGV---FQSTDTCYVLSFAVIMLNTSLHNPNVRD--KPGLERFVAMNRGINEGGDLPEE 229
           NPGV   F++ DT ++L+FA+I+LNT +++PNV+   K  LE F+   RG+++G D+P E
Sbjct: 639 NPGVVRQFRNPDTIFILAFAIILLNTDMYSPNVKPERKMKLEDFIKNLRGVDDGEDIPRE 698

Query: 230 LLRNLYDSIRNEPFKIPED 248
           +L  +Y+ IR    K  ED
Sbjct: 699 MLMGIYERIRKRELKTNED 717


>gi|71143127 IQ motif and Sec7 domain 3 [Homo sapiens]
          Length = 759

 Score =  160 bits (404), Expect = 2e-39
 Identities = 80/194 (41%), Positives = 129/194 (66%), Gaps = 6/194 (3%)

Query: 61  RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGE-RE 119
           R R   +G   FN++P KGIQFL+    + +TP  +A FL + +GL++  IG++LG  ++
Sbjct: 348 RKRLYRIGLNLFNINPDKGIQFLISRGFIPDTPIGVAHFLLQRKGLSRQMIGEFLGNSKK 407

Query: 120 ELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGV- 178
           + N  VL   VD  +F+ + L +ALR+F    R+ GEAQK++R++EAF+QRYC+CNP V 
Sbjct: 408 QFNRDVLDCVVDEMDFSSMELDEALRKFQAHIRVQGEAQKVERLIEAFSQRYCMCNPEVV 467

Query: 179 --FQSTDTCYVLSFAVIMLNTSLHNPNVRD--KPGLERFVAMNRGINEGGDLPEELLRNL 234
             F + DT ++L+FA+I+LNT +++PN++   K  LE F+   RG+++G D+P EL+  +
Sbjct: 468 QQFHNPDTIFILAFAIILLNTDMYSPNIKPDRKMMLEDFIRNLRGVDDGADIPRELVVGI 527

Query: 235 YDSIRNEPFKIPED 248
           Y+ I+ +  K  ED
Sbjct: 528 YERIQQKELKSNED 541


>gi|53832026 IQ motif and Sec7 domain 2 isoform 2 [Homo sapiens]
          Length = 949

 Score =  153 bits (386), Expect = 3e-37
 Identities = 76/194 (39%), Positives = 127/194 (65%), Gaps = 6/194 (3%)

Query: 61  RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGERE- 119
           + R   +G   FN  P+KGIQ+L+E   L +TP  +A F+ + +GL++  IG++LG R+ 
Sbjct: 548 QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK 607

Query: 120 ELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGV- 178
           + N  VL   VD  +F+ ++L  ALR+F    R+ GEAQK++R++EAF+QRYC+CNP + 
Sbjct: 608 QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV 667

Query: 179 --FQSTDTCYVLSFAVIMLNTSLHNPNVR--DKPGLERFVAMNRGINEGGDLPEELLRNL 234
             F++ DT ++L+FA+I+LNT +++P+V+   K  L+ F+   RG++ G D+P +LL  +
Sbjct: 668 RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI 727

Query: 235 YDSIRNEPFKIPED 248
           Y  I+    +  +D
Sbjct: 728 YQRIQGRELRTNDD 741


>gi|162138911 IQ motif and Sec7 domain 2 isoform1 [Homo sapiens]
          Length = 1488

 Score =  153 bits (386), Expect = 3e-37
 Identities = 76/194 (39%), Positives = 127/194 (65%), Gaps = 6/194 (3%)

Query: 61  RNRKMAMGRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGERE- 119
           + R   +G   FN  P+KGIQ+L+E   L +TP  +A F+ + +GL++  IG++LG R+ 
Sbjct: 753 QRRHYRIGLNLFNKKPEKGIQYLIERGFLSDTPVGVAHFILERKGLSRQMIGEFLGNRQK 812

Query: 120 ELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNPGV- 178
           + N  VL   VD  +F+ ++L  ALR+F    R+ GEAQK++R++EAF+QRYC+CNP + 
Sbjct: 813 QFNRDVLDCVVDEMDFSSMDLDDALRKFQSHIRVQGEAQKVERLIEAFSQRYCVCNPALV 872

Query: 179 --FQSTDTCYVLSFAVIMLNTSLHNPNVR--DKPGLERFVAMNRGINEGGDLPEELLRNL 234
             F++ DT ++L+FA+I+LNT +++P+V+   K  L+ F+   RG++ G D+P +LL  +
Sbjct: 873 RQFRNPDTIFILAFAIILLNTDMYSPSVKAERKMKLDDFIKNLRGVDNGEDIPRDLLVGI 932

Query: 235 YDSIRNEPFKIPED 248
           Y  I+    +  +D
Sbjct: 933 YQRIQGRELRTNDD 946


>gi|4758416 golgi-specific brefeldin A resistant guanine nucleotide
           exchange factor 1 [Homo sapiens]
          Length = 1859

 Score =  144 bits (363), Expect = 1e-34
 Identities = 80/195 (41%), Positives = 122/195 (62%), Gaps = 11/195 (5%)

Query: 61  RNRKMAMGRKKFNMDPKKGIQFLVENELL----QNTPEEIARFLYKGEGLNKTAIGDYLG 116
           + + +  G ++FN  PKKGIQFL E  LL     NT  E+A++L +   L+K  IG+++ 
Sbjct: 699 KKKLLITGTEQFNQKPKKGIQFLQEKGLLTIPMDNT--EVAQWLRENPRLDKKMIGEFVS 756

Query: 117 EREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPGEAQKIDRMMEAFAQRYCLCNP 176
           +R+ ++L  L +FV    F  L L +ALR +L +FRLPGEA  I R++EAF +R+  CN 
Sbjct: 757 DRKNIDL--LESFVSTFSFQGLRLDEALRLYLEAFRLPGEAPVIQRLLEAFTERWMNCNG 814

Query: 177 GVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPG---LERFVAMNRGINEGGDLPEELLRN 233
             F ++D C+ L++AVIMLNT  HN NVR +     LE F    +G+N G D  +++L +
Sbjct: 815 SPFANSDACFSLAYAVIMLNTDQHNHNVRKQNAPMTLEEFRKNLKGVNGGKDFEQDILED 874

Query: 234 LYDSIRNEPFKIPED 248
           +Y +I+NE   +PE+
Sbjct: 875 MYHAIKNEEIVMPEE 889


>gi|56788370 pleckstrin and Sec7 domain containing 4 [Homo sapiens]
          Length = 1056

 Score =  111 bits (277), Expect = 1e-24
 Identities = 91/343 (26%), Positives = 150/343 (43%), Gaps = 75/343 (21%)

Query: 96  IARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPG 155
           +A  LY+ EG  K+ +  YL +  + + AV   ++   +F   +L +ALR FL +  L G
Sbjct: 591 LASRLYRLEGFRKSEVAAYLQKNNDFSRAVAEEYLSFFQFGGQSLDRALRSFLQALVLSG 650

Query: 156 EAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVA 215
           E Q+ +R++  F++R+  CNPG+F S D+ + L+ A+++LNT LH  N+      + F+ 
Sbjct: 651 ETQERERILYQFSRRFHHCNPGIFPSVDSVHTLTCAIMLLNTDLHGQNIGKSMSCQEFIT 710

Query: 216 MNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDDGNDLTHTFFNPD-------------- 261
              G+ +GG+ P+ELL+ LY SIR+E  +   D+ +        P               
Sbjct: 711 NLNGLRDGGNFPKELLKALYWSIRSEKLEWAVDEEDTARPEKAQPSLPAGKMSKPFLQLA 770

Query: 262 --------REGWLLK-----LGGRVKTW-KRRW----FILTDNCLYYFEYTTDKEPRGII 303
                   ++G L +       G+   W KR W     +L    LY+ +   D    G  
Sbjct: 771 QDPTVPTYKQGILARKMHQDADGKKTPWGKRGWKMFHTLLRGMVLYFLKQGEDHCLEG-- 828

Query: 304 PLENLSIREVDDP---------------RKPNCFELYIPNNKGQLIKACKTEADGRVVEG 348
             E+L  + VD+P               +KP+ F+L                AD R    
Sbjct: 829 --ESLVGQMVDEPVGVHHSLATPATHYTKKPHVFQL--------------RTADWR---- 868

Query: 349 NHMVYRISAPTQEEKDEWIKSIQAAV---SVDPFYEMLAARKK 388
              +Y   APT +E   WI  I  A    S  PF   + ++++
Sbjct: 869 ---LYLFQAPTAKEMSSWIARINLAAATHSAPPFPAAVGSQRR 908


>gi|56790299 pleckstrin and Sec7 domain containing [Homo sapiens]
          Length = 1024

 Score =  110 bits (274), Expect = 3e-24
 Identities = 56/156 (35%), Positives = 88/156 (56%)

Query: 94  EEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRL 153
           + +A+ LY+ +G  K  +  +LG+  + +  V   ++    FT + L QALR FL    L
Sbjct: 559 QRLAKRLYRLDGFRKADVARHLGKNNDFSKLVAGEYLKFFVFTGMTLDQALRVFLKELAL 618

Query: 154 PGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERF 213
            GE Q+ +R++  F+QRY  CNP    S D  + L+ A+++LNT LH  N+  +     F
Sbjct: 619 MGETQERERVLAHFSQRYFQCNPEALSSEDGAHTLTCALMLLNTDLHGHNIGKRMTCGDF 678

Query: 214 VAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDD 249
           +    G+N+GGD P ELL+ LY SI+NE  +   D+
Sbjct: 679 IGNLEGLNDGGDFPRELLKALYSSIKNEKLQWAIDE 714


>gi|45827716 ADP-ribosylation factor guanine nucleotide factor 6
           isoform b [Homo sapiens]
          Length = 513

 Score =  109 bits (272), Expect = 5e-24
 Identities = 54/156 (34%), Positives = 92/156 (58%)

Query: 94  EEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRL 153
           + +A+ LY+ +   ++ +  +LG+  E +  V   ++   +FT + L Q+LR F  +F L
Sbjct: 52  KRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSL 111

Query: 154 PGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERF 213
            GE Q+ +R++  F+ RY  CNP    S D  + L+ A+++LNT LH  N+  K   + F
Sbjct: 112 VGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEF 171

Query: 214 VAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDD 249
           +A  +G+NEG D  ++LL+ LY+SI+NE  +   DD
Sbjct: 172 IANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDD 207


>gi|117606360 ADP-ribosylation factor guanine nucleotide factor 6
           isoform a [Homo sapiens]
          Length = 1047

 Score =  109 bits (272), Expect = 5e-24
 Identities = 54/156 (34%), Positives = 92/156 (58%)

Query: 94  EEIARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRL 153
           + +A+ LY+ +   ++ +  +LG+  E +  V   ++   +FT + L Q+LR F  +F L
Sbjct: 586 KRLAKRLYQLDRFKRSDVAKHLGKNNEFSKLVAEEYLKFFDFTGMTLDQSLRYFFKAFSL 645

Query: 154 PGEAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERF 213
            GE Q+ +R++  F+ RY  CNP    S D  + L+ A+++LNT LH  N+  K   + F
Sbjct: 646 VGETQERERVLIHFSNRYFYCNPDTIASQDGVHCLTCAIMLLNTDLHGHNIGKKMTCQEF 705

Query: 214 VAMNRGINEGGDLPEELLRNLYDSIRNEPFKIPEDD 249
           +A  +G+NEG D  ++LL+ LY+SI+NE  +   DD
Sbjct: 706 IANLQGVNEGVDFSKDLLKALYNSIKNEKLEWAVDD 741


>gi|14150035 pleckstrin and Sec7 domain containing 2 [Homo sapiens]
          Length = 771

 Score =  107 bits (268), Expect = 1e-23
 Identities = 58/156 (37%), Positives = 92/156 (58%), Gaps = 2/156 (1%)

Query: 96  IARFLYKGEGLNKTAIGDYLGEREELNLAVLHAFVDLHEFTDLNLVQALRQFLWSFRLPG 155
           +AR LY  EG  +  +   LG+  E +  V   ++   +F+ L L  ALR FL +F L G
Sbjct: 317 LARRLYHLEGFQRCDVARQLGKNNEFSRLVAGEYLSFFDFSGLTLDGALRTFLKAFPLMG 376

Query: 156 EAQKIDRMMEAFAQRYCLCNPGVFQSTDTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVA 215
           E Q+ +R++  F++RYC CNP    S D  + L+ A+++LNT LH  N+  K   ++F+A
Sbjct: 377 ETQERERVLTHFSRRYCQCNPDDSTSEDGIHTLTCALMLLNTDLHGHNIGKKMSCQQFIA 436

Query: 216 MNRGINEGGDLPEELLRNLYDSIRNEPFK--IPEDD 249
               +N+G D  ++LL+ LY+SI+NE  +  I ED+
Sbjct: 437 NLDQLNDGQDFAKDLLKTLYNSIKNEKLEWAIDEDE 472


>gi|48928044 F-box only protein 8 [Homo sapiens]
          Length = 319

 Score = 93.2 bits (230), Expect = 4e-19
 Identities = 54/176 (30%), Positives = 95/176 (53%), Gaps = 11/176 (6%)

Query: 68  GRKKFNMDPKKGIQFLVENELLQNTPEEIARFLYKGEGLNKTAIGDYLGEREELNLAVLH 127
           G   FN +P +G+ + +   +L ++P+EIA+F++    LN   +  YL ER +    VL 
Sbjct: 142 GSLTFNANPDEGVNYFMSKGILDDSPKEIAKFIFCTRTLNWKKLRIYLDERRD----VLD 197

Query: 128 AFVDLHEFTDLNLVQALRQFLWSFRLPGE-AQKIDRMMEAFAQRYCLCNPGVFQ----ST 182
             V LH F +  L  ALR+F      P E  + ++ ++  F+ R+C CNP + +    S 
Sbjct: 198 DLVTLHNFRNQFLPNALREFFRHIHAPEERGEYLETLITKFSHRFCACNPDLMRELGLSP 257

Query: 183 DTCYVLSFAVIMLNTSLHNPNVRDKPGLERFVAMNRGINEGGDLPEELLRNLYDSI 238
           D  YVL +++I+L+  L +P+V++K     F+   R      ++ E+ + +LYD+I
Sbjct: 258 DAVYVLCYSLILLSIDLTSPHVKNKMSKREFIRNTR--RAAQNISEDFVGHLYDNI 311


>gi|111154092 Rho GTPase activating protein 24 isoform 1 [Homo
           sapiens]
          Length = 748

 Score = 66.2 bits (160), Expect = 5e-11
 Identities = 38/111 (34%), Positives = 54/111 (48%), Gaps = 10/111 (9%)

Query: 264 GWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNCFE 323
           GWL K GG VKTW  RWF+L  + LYYF+   + +P G I L    + E        C E
Sbjct: 24  GWLRKQGGFVKTWHTRWFVLKGDQLYYFKDEDETKPLGTIFLPGNKVSE------HPCNE 77

Query: 324 LYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAV 374
                N G+ +       D   +  NH  Y + A TQ + ++W+KSI+  +
Sbjct: 78  ----ENPGKFLFEVVPGGDRDRMTANHESYLLMASTQNDMEDWVKSIRRVI 124


>gi|158631203 dual adaptor of phosphotyrosine and
           3-phosphoinositides [Homo sapiens]
          Length = 280

 Score = 57.0 bits (136), Expect = 3e-08
 Identities = 39/115 (33%), Positives = 50/115 (43%), Gaps = 23/115 (20%)

Query: 262 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVD-DPRKPN 320
           +EG+L K GG VKTWK RWF L  N L YF+     EP  I+ L   S  + D    + N
Sbjct: 167 KEGYLTKQGGLVKTWKTRWFTLHRNELKYFKDQMSPEPIRILDLTECSAVQFDYSQERVN 226

Query: 321 CFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVS 375
           CF L  P                         + + A T  E DEWIK ++  +S
Sbjct: 227 CFCLVFP----------------------FRTFYLCAKTGVEADEWIKILRWKLS 259


>gi|239047795 pleckstrin homology domain containing, family A member
           7 [Homo sapiens]
          Length = 1121

 Score = 56.6 bits (135), Expect = 4e-08
 Identities = 32/115 (27%), Positives = 56/115 (48%), Gaps = 2/115 (1%)

Query: 264 GWLLKLGGR-VKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREV-DDPRKPNC 321
           GWL K     ++ WKRRWF+L D CL+Y++ + ++   G IPL +  I  V  + R    
Sbjct: 169 GWLHKQDSSGMRLWKRRWFVLADYCLFYYKDSREEAVLGSIPLPSYVISPVAPEDRISRK 228

Query: 322 FELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSV 376
           +     +   + +    + A  +  +     Y  SA TQE+ + W++++  A  V
Sbjct: 229 YSFKAVHTGMRALIYNSSTAGSQAEQSGMRTYYFSADTQEDMNAWVRAMNQAAQV 283


>gi|145312241 differentially expressed in FDCP 6 homolog [Homo
           sapiens]
          Length = 631

 Score = 55.8 bits (133), Expect = 7e-08
 Identities = 37/137 (27%), Positives = 62/137 (45%), Gaps = 22/137 (16%)

Query: 262 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNC 321
           ++G+L K G   + W  RWF L  +CL YF     KE RGIIPL+             +C
Sbjct: 219 KQGYLWKRGHLRRNWAERWFQLQPSCLCYFGSEECKEKRGIIPLD------------AHC 266

Query: 322 FELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSVDPFYE 381
               +P+  G+    C        V+  +  Y +SA    ++ EW  +IQ A+ +    E
Sbjct: 267 CVEVLPDRDGKRCMFC--------VKTANRTYEMSASDTRQRQEWTAAIQMAIRLQA--E 316

Query: 382 MLAARKKRISVKKKQEQ 398
              +  K +  K+++++
Sbjct: 317 GKTSLHKDLKQKRREQR 333



 Score = 29.3 bits (64), Expect = 6.6
 Identities = 14/38 (36%), Positives = 24/38 (63%)

Query: 14  EERMELENIRRRKQELLVEIQRLREELSEAMSEVEGLE 51
           E+R + E  R  K+E L+ +Q+L+EE    + E+E L+
Sbjct: 331 EQREQRERRRAAKEEELLRLQQLQEEKERKLQELELLQ 368


>gi|24432056 hypothetical protein LOC144717 [Homo sapiens]
          Length = 249

 Score = 54.7 bits (130), Expect = 1e-07
 Identities = 33/114 (28%), Positives = 53/114 (46%), Gaps = 22/114 (19%)

Query: 261 DREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPN 320
           D  G+L K GGR   + RRWF+L  N L+YFE    +EP G+I LE  ++          
Sbjct: 19  DNAGFLYKKGGRHAAYHRRWFVLRGNMLFYFEDAASREPVGVIILEGCTV---------- 68

Query: 321 CFELYIPNNKGQLIKACKTEADG-RVVEGNHMVYRISAPTQEEKDEWIKSIQAA 373
                      +L++A +  A   R        Y ++A +Q+  + W+K++  A
Sbjct: 69  -----------ELVEAAEEFAFAVRFAGTRARTYVLAAESQDAMEGWVKALSRA 111


>gi|34013590 Rho GTPase activating protein 2 [Homo sapiens]
          Length = 698

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 31/117 (26%), Positives = 60/117 (51%), Gaps = 16/117 (13%)

Query: 262 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREV----DDPR 317
           + GWL K    +K W++RWF+L  + L+Y++   + +P+G I L+   + E+    +DP 
Sbjct: 40  KAGWLKKQRSIMKNWQQRWFVLRGDQLFYYKDKDEIKPQGFISLQGTQVTELPPGPEDPG 99

Query: 318 KPNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAV 374
           K + FE+  P   G+  K          V  N     + A +Q + ++W+++I+  +
Sbjct: 100 K-HLFEI-SPGGAGEREK----------VPANPEALLLMASSQRDMEDWVQAIRRVI 144


>gi|93102364 SWAP-70 protein [Homo sapiens]
          Length = 585

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 40/141 (28%), Positives = 67/141 (47%), Gaps = 29/141 (20%)

Query: 262 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNC 321
           ++G+++K G R K W  RWF+L  N + Y+     K+ +G I L+             NC
Sbjct: 213 KQGYMMKKGHRRKNWTERWFVLKPNIISYYVSEDLKDKKGDILLDE------------NC 260

Query: 322 FELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAV------S 375
               +P+  G   K C       +V+     + ISA  +++K EWI++I + +      S
Sbjct: 261 CVESLPDKDG---KKCLF-----LVKCFDKTFEISASDKKKKQEWIQAIHSTIHLLKLGS 312

Query: 376 VDPFYEMLAARKKRISVKKKQ 396
             P  E   AR++R  ++KKQ
Sbjct: 313 PPPHKE---ARQRRKELRKKQ 330


>gi|50234893 pleckstrin homology domain containing, family A
           (phosphoinositide binding specific) member 1 [Homo
           sapiens]
          Length = 404

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 30/113 (26%), Positives = 57/113 (50%), Gaps = 18/113 (15%)

Query: 262 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNC 321
           + G+ +K G  +K WKRR+F L +N + YF+   +KEP  +IPL     +EV   ++   
Sbjct: 194 KAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPL-----KEVHKVQECKQ 248

Query: 322 FELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAV 374
            ++ + +N  +++   +T             + + A + EE   WIK++  A+
Sbjct: 249 SDIMMRDNLFEIVTTSRT-------------FYVQADSPEEMHSWIKAVSGAI 288


>gi|31377720 pleckstrin homology domain containing, family A
           (phosphoinositide binding specific) member 1 [Homo
           sapiens]
          Length = 404

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 30/113 (26%), Positives = 57/113 (50%), Gaps = 18/113 (15%)

Query: 262 REGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRKPNC 321
           + G+ +K G  +K WKRR+F L +N + YF+   +KEP  +IPL     +EV   ++   
Sbjct: 194 KAGYCVKQGAVMKNWKRRYFQLDENTIGYFKSELEKEPLRVIPL-----KEVHKVQECKQ 248

Query: 322 FELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAV 374
            ++ + +N  +++   +T             + + A + EE   WIK++  A+
Sbjct: 249 SDIMMRDNLFEIVTTSRT-------------FYVQADSPEEMHSWIKAVSGAI 288


>gi|55741447 pleckstrin homology domain containing, family H (with
           MyTH4 domain) member 1 [Homo sapiens]
          Length = 1364

 Score = 52.0 bits (123), Expect = 9e-07
 Identities = 30/118 (25%), Positives = 60/118 (50%), Gaps = 26/118 (22%)

Query: 261 DREGWLLKLGGRVKTWKRRWFILTDNCLYYFEYTTD--KEPRGIIPLENLSIREVDDPRK 318
           ++ G+LLK+G +VKTWKRRWF+L    + Y++  +D  ++P+G + L             
Sbjct: 580 EKSGYLLKMGSQVKTWKRRWFVLRQGQIMYYKSPSDVIRKPQGQVDL------------- 626

Query: 319 PNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAAVSV 376
                    N++ Q+++   ++    + E     Y ++A +    +EWI+ +Q+ + V
Sbjct: 627 ---------NSRCQIVRGEGSQTFQLISE--KKTYYLTADSPSLLEEWIRVLQSLLKV 673



 Score = 38.5 bits (88), Expect = 0.011
 Identities = 36/133 (27%), Positives = 52/133 (39%), Gaps = 14/133 (10%)

Query: 260 PDREGWLLKLG-GRVKTWKRRWFILTDNCLYYFEYTTDKEPRGIIPLENLSIREVDDPRK 318
           P  +GWL K+  G  K     W  L     YY+    DK P G +P+ +  I EVD  R 
Sbjct: 688 PTVKGWLTKVKHGHSKVV---WCALVGKIFYYYRSHEDKRPLGCLPVRDAHIEEVD--RS 742

Query: 319 PNCFELYIPNNKGQLIKACKTEADGRVVEGNHMVYRISAPTQEEKDEWIKSIQAA----- 373
            +  E Y      +L+ +  T     +    H    +   T+ EKD W+  +  A     
Sbjct: 743 CDSDEDYEAGGTRRLLSSHCTLV---IHPTEHSPTYLLIGTKHEKDTWLYHLTVAAGGSS 799

Query: 374 VSVDPFYEMLAAR 386
             V   YE L  +
Sbjct: 800 AKVGTAYEQLIGK 812


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.137    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,755,135
Number of Sequences: 37866
Number of extensions: 714143
Number of successful extensions: 3369
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 123
Number of HSP's successfully gapped in prelim test: 134
Number of HSP's that attempted gapping in prelim test: 3007
Number of HSP's gapped (non-prelim): 498
length of query: 399
length of database: 18,247,518
effective HSP length: 104
effective length of query: 295
effective length of database: 14,309,454
effective search space: 4221288930
effective search space used: 4221288930
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.