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Search of human proteins with 19482174
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|19482174 cullin 2 [Homo sapiens]
(745 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|19482174 cullin 2 [Homo sapiens] 1489 0.0
gi|32307161 cullin 1 [Homo sapiens] 515 e-146
gi|4503165 cullin 3 [Homo sapiens] 315 1e-85
gi|121114302 cullin 4B isoform 2 [Homo sapiens] 308 9e-84
gi|121114298 cullin 4B isoform 1 [Homo sapiens] 308 9e-84
gi|40254446 Vasopressin-activated calcium-mobilizing receptor-1 ... 292 7e-79
gi|57165424 cullin 4A isoform 1 [Homo sapiens] 286 6e-77
gi|11140811 cullin 4A isoform 2 [Homo sapiens] 278 2e-74
gi|7019327 anaphase-promoting complex subunit 2 [Homo sapiens] 51 3e-06
gi|24308456 ELMO/CED-12 domain containing 2 [Homo sapiens] 35 0.25
gi|169218008 PREDICTED: similar to anaphase-promoting complex su... 33 0.96
gi|18093112 ABT1-associated protein [Homo sapiens] 33 0.96
gi|41281612 zinc finger protein 828 [Homo sapiens] 33 1.3
gi|58535451 CDK5 regulatory subunit associated protein 2 isoform... 32 1.6
gi|55769583 progesterone-induced blocking factor 1 [Homo sapiens] 32 1.6
gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1 precu... 31 4.8
gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2 pre... 31 4.8
gi|50658071 phosphodiesterase 4D interacting protein isoform 5 [... 31 4.8
gi|93102364 SWAP-70 protein [Homo sapiens] 30 6.2
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 30 6.2
gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens] 30 6.2
gi|14702171 DNA directed RNA polymerase II polypeptide C [Homo s... 30 6.2
gi|118918407 spectrin repeat containing, nuclear envelope 2 isof... 30 8.1
gi|118918403 spectrin repeat containing, nuclear envelope 2 isof... 30 8.1
gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo ... 30 8.1
gi|111548666 SNF2 histone linker PHD RING helicase isoform a [Ho... 30 8.1
gi|27436873 SNF2 histone linker PHD RING helicase isoform b [Hom... 30 8.1
gi|150010552 FK506 binding protein 15, 133kDa [Homo sapiens] 30 8.1
>gi|19482174 cullin 2 [Homo sapiens]
Length = 745
Score = 1489 bits (3856), Expect = 0.0
Identities = 745/745 (100%), Positives = 745/745 (100%)
Query: 1 MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTE 60
MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTE
Sbjct: 1 MSLKPRVVDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTE 60
Query: 61 TKIFLENHVRHLHKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTE 120
TKIFLENHVRHLHKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTE
Sbjct: 61 TKIFLENHVRHLHKRVLESEEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTE 120
Query: 121 ADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV 180
ADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV
Sbjct: 121 ADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKV 180
Query: 181 IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVL 240
IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVL
Sbjct: 181 IHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVL 240
Query: 241 GRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMANMYVL 300
GRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMANMYVL
Sbjct: 241 GRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMANMYVL 300
Query: 301 LRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG 360
LRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG
Sbjct: 301 LRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNG 360
Query: 361 DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFIT 420
DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFIT
Sbjct: 361 DQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFIT 420
Query: 421 VFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDM 480
VFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDM
Sbjct: 421 VFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDM 480
Query: 481 SVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF 540
SVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF
Sbjct: 481 SVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMF 540
Query: 541 ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQ 600
ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQ
Sbjct: 541 ELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQ 600
Query: 601 DSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKD 660
DSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKD
Sbjct: 601 DSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKD 660
Query: 661 TPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKK 720
TPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKK
Sbjct: 661 TPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKK 720
Query: 721 CIEVLIDKQYIERSQASADEYSYVA 745
CIEVLIDKQYIERSQASADEYSYVA
Sbjct: 721 CIEVLIDKQYIERSQASADEYSYVA 745
>gi|32307161 cullin 1 [Homo sapiens]
Length = 776
Score = 515 bits (1327), Expect = e-146
Identities = 285/779 (36%), Positives = 450/779 (57%), Gaps = 58/779 (7%)
Query: 8 VDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEP--------------- 52
+ D+ W+ L I+ V + + ++ + + ++ +Y C + +
Sbjct: 15 IGLDQIWDDLRAGIQQVYTRQSMAKSRYMELYTHVYNYCTSVHQSNQARGAGVPPSKSKK 74
Query: 53 ---------LGERLYTETKIFLENHVRHLHKRVLE-SEEQVLVMYHRYWEEYSKGADYMD 102
+G LY K FL+N++ +L K + +E VL Y + WE+Y + ++
Sbjct: 75 GQTPGGAQFVGLELYKRLKEFLKNYLTNLLKDGEDLMDESVLKFYTQQWEDYRFSSKVLN 134
Query: 103 CLYRYLNTQFIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRM 162
+ YLN ++++ E D + + + EI LAL WR + PL +
Sbjct: 135 GICAYLNRHWVRR----ECD--------EGRKGIYEIYSLALVTWRDCLFRPLNKQVTNA 182
Query: 163 LLREIKNDRGGEDPNQKVIHGVINSFVHV-----EQYKKKFPLKFYQEIFESPFLTETGE 217
+L+ I+ +R GE N ++I GV+ S+V + + + K L Y+E FES FL +T
Sbjct: 183 VLKLIEKERNGETINTRLISGVVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTER 242
Query: 218 YYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQF 277
+Y +E++ LQ++ ++YM+K RL +E+ R + YLH S+ ++ +C+Q ++ HL+
Sbjct: 243 FYTRESTEFLQQNPVTEYMKKAEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKHLEI 302
Query: 278 LHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQE--NM 335
H E N++ +K D+ MY L+ + GL + + L+ HIH++GL A + N
Sbjct: 303 FHTEFQNLLDADKNEDLGRMYNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALND 362
Query: 336 PTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNY----REPKSVCKAPELL 391
P ++V++VL+VH K+ L+ + N D F++ALDKA +N + +S K+PELL
Sbjct: 363 PKMYVQTVLDVHKKYNALVMSAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELL 422
Query: 392 AKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSM 451
A+YCD+LLKKS+K E E+ED L + VFKYI+DKDVFQKFYA+MLAKRL+H S S
Sbjct: 423 ARYCDSLLKKSSKNPEEAELEDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASD 482
Query: 452 DSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYV 511
D+E +MI+KLKQACG+E+TSKL RM+ D+ VS DLN +F + N + L + F I V
Sbjct: 483 DAEASMISKLKQACGFEYTSKLQRMFQDIGVSKDLNEQFKKHLTNSE---PLDLDFSIQV 539
Query: 512 LQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGK 571
L +G+WP Q S TFA+P ELE+S Q F FY+ SGRKLTWL+ L GE+ N
Sbjct: 540 LSSGSWPFQQ--SCTFALPSELERSYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKN 597
Query: 572 PYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKED 631
Y +T+QMA+LL +N + + ++L DSTQ+ L + ++ LL K++ + E +
Sbjct: 598 RYTLQASTFQMAILLQYNTEDAYTVQQLTDSTQIKMDILAQVLQILLKSKLLVLEDENAN 657
Query: 632 ID-----AESSFSLNMNFSSKRTKFKITTSMQKDTPQEMEQTRSAVDEDRKMYLQAAIVR 686
+D ++ L + + +K+ + I M+ + QE E T ++EDRK+ +QAAIVR
Sbjct: 658 VDEVELKPDTLIKLYLGYKNKKLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVR 717
Query: 687 IMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA 745
IMK RKVL+H L+ EV++Q +RF P + +IKKCI++LI+K+Y+ER D YSY+A
Sbjct: 718 IMKMRKVLKHQQLLGEVLTQLSSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA 776
>gi|4503165 cullin 3 [Homo sapiens]
Length = 768
Score = 315 bits (807), Expect = 1e-85
Identities = 205/728 (28%), Positives = 374/728 (51%), Gaps = 65/728 (8%)
Query: 54 GERLYTETKIFLENH-VRHLHKRVLES-EEQVLVMYHRYWEEYSKGADYMDCLYRYLNTQ 111
GE+LYT + + H + + + VL S L ++ W ++ + + Y++
Sbjct: 70 GEKLYTGLREVVTEHLINKVREDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRV 129
Query: 112 FIKKNKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDR 171
++++N + Y G + + ++ G + + L+ L+ M+ RE K +
Sbjct: 130 YVQQNNVENV---YNLGLIIFRDQVVRYGCIR---------DHLRQTLLDMIARERKGE- 176
Query: 172 GGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESN 231
V G I + + Y+E FE+PFL + E+++ E+ L E++
Sbjct: 177 -------VVDRGAIRNACQMLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENS 229
Query: 232 CSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAECHN-----II 286
S Y++KV R+ +E R L S+ ++ ++ +++ H++ + E N ++
Sbjct: 230 ASVYIKKVEARINEEIERVMHCLDKSTEEPIVKVVERELISKHMKTI-VEMENSGLVHML 288
Query: 287 RQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEV 346
+ K D+ MY L V GL M + + +++ ++G S + P +++ +L++
Sbjct: 289 KNGKTEDLGCMYKLFSRVPNGLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDL 348
Query: 347 HGKFVQLINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGM 406
+F + + N D+ F + +N ++PE L+ + D+ LKK KG+
Sbjct: 349 KSRFDRFLLESFNNDRLFKQTIAGDFEYFLNLNS-----RSPEYLSLFIDDKLKKGVKGL 403
Query: 407 TENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACG 466
TE EVE L + +F+++ +KDVF+++Y + LA+RL+ S+S DSE+ MI+KLK CG
Sbjct: 404 TEQEVETILDKAMVLFRFMQEKDVFERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECG 463
Query: 467 YEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDL-GISFQIYVLQAGAWPLTQAPSS 525
+FTSKL M+ DMS+S ++F + Q T + L G+ + VL G WP TQ+ +
Sbjct: 464 CQFTSKLEGMFRDMSISNTTMDEFRQHL--QATGVSLGGVDLTVRVLTTGYWP-TQSATP 520
Query: 526 TFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLG--------------- 570
IP + ++F FY SGR+LT H++ + ++ + G
Sbjct: 521 KCNIPPAPRHAFEIFRRFYLAKHSGRQLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGA 580
Query: 571 -------KPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLL----D 619
+ ++ V+T+QM +L+ FNN E +++E+Q T + E+EL + ++SL
Sbjct: 581 QVTGSNTRKHILQVSTFQMTILMLFNNREKYTFEEIQQETDIPERELVRALQSLACGKPT 640
Query: 620 VKMINHDSEKEDIDAESSFSLNMNFSSK--RTKFKITTSMQKDTPQEMEQTRSAVDEDRK 677
+++ + + ++I+ F++N F+SK R K + + Q ++ E ++TR VD+DRK
Sbjct: 641 QRVLTKEPKSKEIENGHIFTVNDQFTSKLHRVKIQTVAAKQGESDPERKETRQKVDDDRK 700
Query: 678 MYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQAS 737
++AAIVRIMK+RK ++HN L+ EV Q +ARF PS +IKK IE LI+++Y+ R+
Sbjct: 701 HEIEAAIVRIMKSRKKMQHNVLVAEVTQQLKARFLPSPVVIKKRIEGLIEREYLARTPED 760
Query: 738 ADEYSYVA 745
Y+YVA
Sbjct: 761 RKVYTYVA 768
>gi|121114302 cullin 4B isoform 2 [Homo sapiens]
Length = 895
Score = 308 bits (790), Expect = 9e-84
Identities = 212/743 (28%), Positives = 381/743 (51%), Gaps = 51/743 (6%)
Query: 11 DETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVR 70
DETW KL ++A+ + + + + + LC + LY + + E+H++
Sbjct: 196 DETWQKLKEAVEAIQNSTSI-KYNLEELYQAVENLC---SYKISANLYKQLRQICEDHIK 251
Query: 71 -HLHKRVLESEEQVLVM--YHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGY 127
+H+ +S + VL + R W+ + + + ++ +L+ ++ +N +
Sbjct: 252 AQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSM--------- 302
Query: 128 GGVDMNEPLMEIGELALDMWRKLMV--EPLQAILIRMLLREIKNDRGGEDPNQKVIHGVI 185
L I ++ L+++R ++ + +Q I +L I+ +R GE ++ ++ ++
Sbjct: 303 --------LPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLL 354
Query: 186 NSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKD 245
+ L+ YQ+ FE FL ET Y E L+QE +Y+ V RL++
Sbjct: 355 SMLSD---------LQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEE 405
Query: 246 EEIRCRKYLHPSSYTKVIHECQQRMVADHLQ-FLHAECHNIIRQEKKNDMANMYVLLRAV 304
E R YL ++ +I +++++ +HL L +N++ + + D++ +Y L V
Sbjct: 406 EADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRV 465
Query: 305 STGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNGDQHF 364
G+ ++Q+ +I G +T + E T+ V+ +L+ K +I+ ++ F
Sbjct: 466 RGGVQVLLQQWIEYIKAFG--STIVINPEKDKTM-VQELLDFKDKVDHIIDICFLKNEKF 522
Query: 365 MSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKY 424
++A+ +A + +N R K EL+AKY D+ L+ K T+ E+E L + +F++
Sbjct: 523 INAMKEAFETFINKRPNKPA----ELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRF 578
Query: 425 IDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSA 484
I KDVF+ FY + LAKRL+ G S S+D+E++M++KLK CG FTSKL M+ DM +S
Sbjct: 579 IYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSK 638
Query: 485 DLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFY 544
D+ +F +++NQ+ + I + +L G WP T P +P E+ K ++F+ FY
Sbjct: 639 DIMIQFKQYMQNQN--VPGNIELTVNILTMGYWP-TYVPMEVH-LPPEMVKLQEIFKTFY 694
Query: 545 SQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQ 604
SGRKL W L +K + V+ +Q VLL FN E S +E++ +T
Sbjct: 695 LGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATG 754
Query: 605 MNEKELTKTIKSLL--DVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKDTP 662
+ + EL +T++SL +++ + + +DI+ F N +F K + KI K+T
Sbjct: 755 IEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETV 814
Query: 663 QEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCI 722
+E T V +DR+ + AAIVRIMK RK L HN L+ EV +Q + P + +KK I
Sbjct: 815 EEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKP--ADLKKRI 872
Query: 723 EVLIDKQYIERSQASADEYSYVA 745
E LID+ Y+ER + + ++Y+Y+A
Sbjct: 873 ESLIDRDYMERDKENPNQYNYIA 895
>gi|121114298 cullin 4B isoform 1 [Homo sapiens]
Length = 913
Score = 308 bits (790), Expect = 9e-84
Identities = 212/743 (28%), Positives = 381/743 (51%), Gaps = 51/743 (6%)
Query: 11 DETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLENHVR 70
DETW KL ++A+ + + + + + LC + LY + + E+H++
Sbjct: 214 DETWQKLKEAVEAIQNSTSI-KYNLEELYQAVENLC---SYKISANLYKQLRQICEDHIK 269
Query: 71 -HLHKRVLESEEQVLVM--YHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQYGY 127
+H+ +S + VL + R W+ + + + ++ +L+ ++ +N +
Sbjct: 270 AQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYVLQNSM--------- 320
Query: 128 GGVDMNEPLMEIGELALDMWRKLMV--EPLQAILIRMLLREIKNDRGGEDPNQKVIHGVI 185
L I ++ L+++R ++ + +Q I +L I+ +R GE ++ ++ ++
Sbjct: 321 --------LPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLL 372
Query: 186 NSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKD 245
+ L+ YQ+ FE FL ET Y E L+QE +Y+ V RL++
Sbjct: 373 SMLSD---------LQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEE 423
Query: 246 EEIRCRKYLHPSSYTKVIHECQQRMVADHLQ-FLHAECHNIIRQEKKNDMANMYVLLRAV 304
E R YL ++ +I +++++ +HL L +N++ + + D++ +Y L V
Sbjct: 424 EADRLITYLDQTTQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRV 483
Query: 305 STGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNGDQHF 364
G+ ++Q+ +I G +T + E T+ V+ +L+ K +I+ ++ F
Sbjct: 484 RGGVQVLLQQWIEYIKAFG--STIVINPEKDKTM-VQELLDFKDKVDHIIDICFLKNEKF 540
Query: 365 MSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKY 424
++A+ +A + +N R K EL+AKY D+ L+ K T+ E+E L + +F++
Sbjct: 541 INAMKEAFETFINKRPNKPA----ELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRF 596
Query: 425 IDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSA 484
I KDVF+ FY + LAKRL+ G S S+D+E++M++KLK CG FTSKL M+ DM +S
Sbjct: 597 IYGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSK 656
Query: 485 DLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFY 544
D+ +F +++NQ+ + I + +L G WP T P +P E+ K ++F+ FY
Sbjct: 657 DIMIQFKQYMQNQN--VPGNIELTVNILTMGYWP-TYVPMEVH-LPPEMVKLQEIFKTFY 712
Query: 545 SQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQ 604
SGRKL W L +K + V+ +Q VLL FN E S +E++ +T
Sbjct: 713 LGKHSGRKLQWQSTLGHCVLKAEFKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATG 772
Query: 605 MNEKELTKTIKSLL--DVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKDTP 662
+ + EL +T++SL +++ + + +DI+ F N +F K + KI K+T
Sbjct: 773 IEDGELRRTLQSLACGKARVLAKNPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETV 832
Query: 663 QEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCI 722
+E T V +DR+ + AAIVRIMK RK L HN L+ EV +Q + P + +KK I
Sbjct: 833 EEQASTTERVFQDRQYQIDAAIVRIMKMRKTLSHNLLVSEVYNQLKFPVKP--ADLKKRI 890
Query: 723 EVLIDKQYIERSQASADEYSYVA 745
E LID+ Y+ER + + ++Y+Y+A
Sbjct: 891 ESLIDRDYMERDKENPNQYNYIA 913
>gi|40254446 Vasopressin-activated calcium-mobilizing receptor-1
[Homo sapiens]
Length = 780
Score = 292 bits (748), Expect = 7e-79
Identities = 212/787 (26%), Positives = 383/787 (48%), Gaps = 68/787 (8%)
Query: 8 VDFDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTETKIFLEN 67
+ F++ W+ + + ++ E V + W D FSD++A+C+ + + +++ K +
Sbjct: 13 LQFEDKWDFMRPIVLKLLRQESVTKQQWFDLFSDVHAVCL-WDDKGPAKIHQALKEDILE 71
Query: 68 HVRHLHKRVLESEEQVLVM--YHRYWEEYSKGADYMDCLYRYLNTQFIKKNKLTEADLQY 125
++ RVL ++ ++ Y W ++ D + + L + K +
Sbjct: 72 FIKQAQARVLSHQDDTALLKAYIVEWRKFFTQCDILPKPFCQLEITLMGKQGSNKKS--- 128
Query: 126 GYGGVDMNEPLMEIGELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKVIHGVI 185
N + +L LD W + + ++ L ++ + +R GE + +++ GV
Sbjct: 129 -------NVEDSIVRKLMLDTWNESIFSNIKNRLQDSAMKLVHAERLGEAFDSQLVIGVR 181
Query: 186 NSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKD 245
S+V++ + L+ Y++ FE +L T +Y+ +A + LQ++ YM+ +LK+
Sbjct: 182 ESYVNLCSNPED-KLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKE 240
Query: 246 EEIRCRKYLHP----SSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMANMYVLL 301
EE R +YL +S ++ C +V + + AEC +I++ + + M+ L+
Sbjct: 241 EEKRALRYLETRRECNSVEALMECCVNALVTSFKETILAECQGMIKRNETEKLHLMFSLM 300
Query: 302 RAVSTGLPHMIQELQNHIHDEGLR----ATSNLTQENMPTLFVESVLEVHGKFVQLINTV 357
V G+ M+++L+ HI GL A +T ++ +VE +L + +F +L+
Sbjct: 301 DKVPNGIEPMLKDLEEHIISAGLADMVAAAETITTDSEK--YVEQLLTLFNRFSKLVKEA 358
Query: 358 LNGDQHFMSALDKALTSVVN------------------YREPKSVCKAPELLAKYCDNLL 399
D F++A DKA +VVN +P+S C PELLA YCD LL
Sbjct: 359 FQDDPRFLTARDKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKC--PELLANYCDMLL 416
Query: 400 KKS--AKGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAM 457
+K+ +K +T E+E +L + V KY+ +KDVF +++ L +RLI +S + EE M
Sbjct: 417 RKTPLSKKLTSEEIEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENM 476
Query: 458 INKLKQA-CGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGA 516
+ L++ ++ +KL RM+ D+ VS DLN F KN + S I +L AGA
Sbjct: 477 VEWLREVGMPADYVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPAD-SVNIKILNAGA 535
Query: 517 WPLTQAPSSTF-AIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVA 575
W +++ F ++P ELE + E FY ++ SGRKL W H + G + Y
Sbjct: 536 W--SRSSEKVFVSLPTELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDL 593
Query: 576 MVTTYQMAVLLAFNNS--ETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHD------- 626
VTT+Q+AVL A+N E +S++ L+ +T++ + EL +T+ SL+ +
Sbjct: 594 EVTTFQLAVLFAWNQRPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYEPQ 653
Query: 627 -SEKEDIDAESSFSLNMNFS-------SKRTKFKITTSMQKDTPQEMEQTRSAVDEDRKM 678
+ +D + FS+N FS KR K + +Q T + E+ + + R +
Sbjct: 654 VNSPKDFTEGTLFSVNQEFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRIL 713
Query: 679 YLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLIDKQYIERSQASA 738
Q AI++IMK RK + + L E++ + F P MIK+ IE LI+ +YI R ++
Sbjct: 714 RTQEAIIQIMKMRKKISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDI 773
Query: 739 DEYSYVA 745
+ + Y+A
Sbjct: 774 NTFIYMA 780
>gi|57165424 cullin 4A isoform 1 [Homo sapiens]
Length = 759
Score = 286 bits (731), Expect = 6e-77
Identities = 212/756 (28%), Positives = 370/756 (48%), Gaps = 61/756 (8%)
Query: 4 KPRVVD--FDETWNKLLTTIKAVVMLEYVERATWNDRFSDIYALCVAYPEPLGERLYTET 61
+PR+ D +TW KL ++AV + R + + + LC P+ LY +
Sbjct: 51 RPRLPDNYTQDTWRKLHEAVRAVQSSTSI-RYNLEELYQAVENLCSHKVSPM---LYKQL 106
Query: 62 KIFLENHVRHLHKRVLESEEQVL--VMY----HRYWEEYSKGADYMDCLYRYLNTQFIKK 115
+ E+HV+ ++L E L V++ + W+++ + + ++ +L+ ++ +
Sbjct: 107 RQACEDHVQ---AQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYVLQ 163
Query: 116 NKLTEADLQYGYGGVDMNEPLMEIGELALDMWRKLMVEP--LQAILIRMLLREIKNDRGG 173
N L I ++ L+++R ++ +Q+ I +L I+ +R G
Sbjct: 164 NST-----------------LPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSG 206
Query: 174 EDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCS 233
E ++ ++ ++ ++ YK F LKF L ET Y E L+QE
Sbjct: 207 EAVDRSLLRSLLGMLSDLQVYKDSFELKF---------LEETNCLYAAEGQRLMQEREVP 257
Query: 234 QYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQ-FLHAECHNIIRQEKKN 292
+Y+ V RL++E R YL S+ +I +++++ +HL L +++ + +
Sbjct: 258 EYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVP 317
Query: 293 DMANMYVLLRAVSTGLPHMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQ 352
D+A MY L V G ++Q +I G N ++ V+ +L+ K
Sbjct: 318 DLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKD---MVQDLLDFKDKVDH 374
Query: 353 LINTVLNGDQHFMSALDKALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVE 412
+I ++ F++ + ++ + +N R K EL+AK+ D+ L+ K T+ E+E
Sbjct: 375 VIEVCFQKNERFVNLMKESFETFINKRPNKPA----ELIAKHVDSKLRAGNKEATDEELE 430
Query: 413 DRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSK 472
L + +F++I KDVF+ FY + LAKRL+ G S S+D+E++M++KLK CG FTSK
Sbjct: 431 RTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSK 490
Query: 473 LHRMYTDMSVSADLNNKFNNFIKNQDTVIDLG-ISFQIYVLQAGAWPLTQAPSSTFAIPQ 531
L M+ DM +S D+ F ++NQ D G I + +L G WP T P P
Sbjct: 491 LEGMFKDMELSKDIMVHFKQHMQNQS---DSGPIDLTVNILTMGYWP-TYTPMEVHLTP- 545
Query: 532 ELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNS 591
E+ K ++F+ FY SGRKL W L +K + V+ +Q VLL FN
Sbjct: 546 EMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEG 605
Query: 592 ETVSYKELQDSTQMNEKELTKTIKSLL--DVKMINHDSEKEDIDAESSFSLNMNFSSKRT 649
+ S++E++ +T + + EL +T++SL +++ + ++++ F N F K
Sbjct: 606 DGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLF 665
Query: 650 KFKITTSMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRA 709
+ KI K+T +E T V +DR+ + AAIVRIMK RK L HN L+ E+ +Q +
Sbjct: 666 RIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKF 725
Query: 710 RFNPSISMIKKCIEVLIDKQYIERSQASADEYSYVA 745
P +KK IE LID+ Y+ER + + ++Y YVA
Sbjct: 726 PVKP--GDLKKRIESLIDRDYMERDKDNPNQYHYVA 759
>gi|11140811 cullin 4A isoform 2 [Homo sapiens]
Length = 659
Score = 278 bits (710), Expect = 2e-74
Identities = 188/619 (30%), Positives = 315/619 (50%), Gaps = 29/619 (4%)
Query: 133 NEPLMEIGELALDMWRKLMVEP--LQAILIRMLLREIKNDRGGEDPNQKVIHGVINSFVH 190
N L I ++ L+++R ++ +Q+ I +L I+ +R GE ++ ++ ++
Sbjct: 64 NSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSD 123
Query: 191 VEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRC 250
++ YK F LKF L ET Y E L+QE +Y+ V RL++E R
Sbjct: 124 LQVYKDSFELKF---------LEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRV 174
Query: 251 RKYLHPSSYTKVIHECQQRMVADHLQ-FLHAECHNIIRQEKKNDMANMYVLLRAVSTGLP 309
YL S+ +I +++++ +HL L +++ + + D+A MY L V G
Sbjct: 175 ITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQ 234
Query: 310 HMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALD 369
++Q +I G N ++ V+ +L+ K +I ++ F++ +
Sbjct: 235 ALLQHWSEYIKTFGTAIVINPEKDKD---MVQDLLDFKDKVDHVIEVCFQKNERFVNLMK 291
Query: 370 KALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKD 429
++ + +N R K EL+AK+ D+ L+ K T+ E+E L + +F++I KD
Sbjct: 292 ESFETFINKRPNKPA----ELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKD 347
Query: 430 VFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNK 489
VF+ FY + LAKRL+ G S S+D+E++M++KLK CG FTSKL M+ DM +S D+
Sbjct: 348 VFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVH 407
Query: 490 FNNFIKNQDTVIDLG-ISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHF 548
F ++NQ D G I + +L G WP T P P E+ K ++F+ FY
Sbjct: 408 FKQHMQNQS---DSGPIDLTVNILTMGYWP-TYTPMEVHLTP-EMIKLQEVFKAFYLGKH 462
Query: 549 SGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEK 608
SGRKL W L +K + V+ +Q VLL FN + S++E++ +T + +
Sbjct: 463 SGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDS 522
Query: 609 ELTKTIKSLL--DVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKDTPQEME 666
EL +T++SL +++ + ++++ F N F K + KI K+T +E
Sbjct: 523 ELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQV 582
Query: 667 QTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLI 726
T V +DR+ + AAIVRIMK RK L HN L+ E+ +Q + P +KK IE LI
Sbjct: 583 STTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKP--GDLKKRIESLI 640
Query: 727 DKQYIERSQASADEYSYVA 745
D+ Y+ER + + ++Y YVA
Sbjct: 641 DRDYMERDKDNPNQYHYVA 659
>gi|7019327 anaphase-promoting complex subunit 2 [Homo sapiens]
Length = 822
Score = 51.2 bits (121), Expect = 3e-06
Identities = 42/202 (20%), Positives = 82/202 (40%), Gaps = 5/202 (2%)
Query: 404 KGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQ 463
K ++ D ++ ++++ KD+F Y +LA RL+H S S + E + LK
Sbjct: 491 KSSSKRRSSDIISLLVSIY---GSKDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKL 547
Query: 464 ACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAP 523
G M DM+ S +N + + +L + WP +
Sbjct: 548 RFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFGVYAVILSSEFWPPFK-- 605
Query: 524 SSTFAIPQELEKSVQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMA 583
+P+++ +++ + Y Q + R L+W H L + + + VT Q
Sbjct: 606 DEKLEVPEDIRAALEAYCKKYEQLKAMRTLSWKHTLGLVTMDVELADRTLSVAVTPVQAV 665
Query: 584 VLLAFNNSETVSYKELQDSTQM 605
+LL F + + + +EL + +M
Sbjct: 666 ILLYFQDQASWTLEELSKAVKM 687
>gi|24308456 ELMO/CED-12 domain containing 2 [Homo sapiens]
Length = 293
Score = 35.0 bits (79), Expect = 0.25
Identities = 22/92 (23%), Positives = 45/92 (48%), Gaps = 6/92 (6%)
Query: 537 VQMFELFYSQHFSGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSY 596
+ ++E FY HF + WL TG+ ++ + YV T+++ L ++ +
Sbjct: 3 ISLWEFFYG-HFFRFWMKWLLRQMTGKCELQRIFDTYVGAQRTHRIENSLTYSKN----- 56
Query: 597 KELQDSTQMNEKELTKTIKSLLDVKMINHDSE 628
K LQ +T + + E+ K + ++ K IN + +
Sbjct: 57 KVLQKATHVVQSEVDKYVDDIMKEKNINPEKD 88
>gi|169218008 PREDICTED: similar to anaphase-promoting complex
subunit 2 [Homo sapiens]
Length = 430
Score = 33.1 bits (74), Expect = 0.96
Identities = 28/143 (19%), Positives = 55/143 (38%), Gaps = 5/143 (3%)
Query: 404 KGMTENEVEDRLTSFITVFKYIDDKDVFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQ 463
K ++ D ++ ++++ KD+F Y +LA RL+H S S + E + LK
Sbjct: 265 KSSSKRRSSDIISLLVSIY---GSKDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKL 321
Query: 464 ACGYEFTSKLHRMYTDMSVSADLNNKFNNFIKNQDTVIDLGISFQIYVLQAGAWPLTQAP 523
G M DM+ S +N + + +L + WP
Sbjct: 322 RFGEAPMHFCEVMLKDMADSRRINANIREEDEKRPAEEQPPFGVYAVILSSEFWP--PFK 379
Query: 524 SSTFAIPQELEKSVQMFELFYSQ 546
+P+++ +++ + Y Q
Sbjct: 380 DEKLEVPEDIRAALEAYCKKYEQ 402
>gi|18093112 ABT1-associated protein [Homo sapiens]
Length = 851
Score = 33.1 bits (74), Expect = 0.96
Identities = 22/121 (18%), Positives = 54/121 (44%), Gaps = 13/121 (10%)
Query: 586 LAFNNSETVSYKELQDSTQMNEKELTKT--IKSLLDVKMINHDSEKEDIDAESS------ 637
L+ +S+ +S K+++ +KE+ ++ + K NH + D ++S
Sbjct: 81 LSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANHKGSENKTDLDNSIGIKKM 140
Query: 638 -----FSLNMNFSSKRTKFKITTSMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKARK 692
F ++ N S K+ + T +K+ ++ T + E+++ L + I+K+ +
Sbjct: 141 KTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSSLEEKQRTLDSGTSEIVKSPR 200
Query: 693 V 693
+
Sbjct: 201 I 201
>gi|41281612 zinc finger protein 828 [Homo sapiens]
Length = 812
Score = 32.7 bits (73), Expect = 1.3
Identities = 26/112 (23%), Positives = 48/112 (42%), Gaps = 17/112 (15%)
Query: 597 KELQDST--QMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKIT 654
K+ Q+S+ +++ E KT +D+K S++E +D ES ++FS + +
Sbjct: 621 KDNQESSDAELSSSEYIKTDLDAMDIKGQESSSDQEQVDVES-----IDFSKENKMDMTS 675
Query: 655 TSMQKDTPQEMEQTRSAVDEDR----------KMYLQAAIVRIMKARKVLRH 696
++ Q E+ + + E+ K Y + R MK VL H
Sbjct: 676 PEQSRNVLQFTEEKEAFISEEEIAKYMKRGKGKYYCKICCCRAMKKGAVLHH 727
>gi|58535451 CDK5 regulatory subunit associated protein 2 isoform a
[Homo sapiens]
Length = 1893
Score = 32.3 bits (72), Expect = 1.6
Identities = 57/261 (21%), Positives = 107/261 (40%), Gaps = 23/261 (8%)
Query: 167 IKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNL 226
IK R + N K+ + V +E ++++ +E E+ L + G ++ L
Sbjct: 1467 IKGSRDKQKENDKLRESLSRKTVSLEHLQREYAS--VKE--ENERLQKEGSEKERHNQQL 1522
Query: 227 LQESNCS-QYMEKVLGRLKDEEIRCRKYLHPSS-----YTKVIHECQQRMVADHLQFLHA 280
+QE CS Q + +V EE++ R+ L + +V + +++ +H + A
Sbjct: 1523 IQEVRCSGQELSRV-----QEEVKLRQQLLSQNDKLLQSLRVELKAYEKLDEEHRRLREA 1577
Query: 281 ECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQE---LQNHIHDEGLRATSNLTQENMPT 337
Q+ D+ ++ + ++A+ L I+ LQ+ + ++ R QE T
Sbjct: 1578 SGEGWKGQDPFRDLHSLLMEIQALRLQLERSIETSSTLQSRLKEQLARGAEK-AQEGALT 1636
Query: 338 LFVESVLEVHGKFVQLINTVLNGDQHFMSALDKA-LTSVVNYREPKSVCKAPELLAKYCD 396
L V++V V L +GD++ M + + L PKSV + P L D
Sbjct: 1637 LAVQAVSIPE---VPLQPDKHDGDKYPMESDNSFDLFDSSQAVTPKSVSETPPLSGNDTD 1693
Query: 397 NLLKKSAKGMTENEVEDRLTS 417
+L S T RL +
Sbjct: 1694 SLSCDSGSSATSTPCVSRLVT 1714
>gi|55769583 progesterone-induced blocking factor 1 [Homo sapiens]
Length = 757
Score = 32.3 bits (72), Expect = 1.6
Identities = 49/212 (23%), Positives = 81/212 (38%), Gaps = 44/212 (20%)
Query: 559 LCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEKELTKTIKSLL 618
+C +VK N L + Q+ L + +Y E+Q Q EL T K L+
Sbjct: 198 ICELQVKKNILAEEL--STNKNQLKQLTETYEEDRKNYSEVQIRCQRLALELADT-KQLI 254
Query: 619 ---DVKMINHDSEKEDIDA---------------ESSFSLNMNFSSKRTKFKIT-----T 655
D + N+D K + DA E+S + S+ +K +T T
Sbjct: 255 QQGDYRQENYDKVKSERDALEQEVIELRRKHEILEASHMIQTKERSELSKEVVTLEQTVT 314
Query: 656 SMQKDTP----QEME-QTRSAVDEDRKMYLQAAIVRIMKARKVL-------------RHN 697
+QKD Q ME R A +EDR LQA + KAR+ + +
Sbjct: 315 LLQKDKEYLNRQNMELSVRCAHEEDRLERLQAQLEESKKAREEMYEKYVASRDHYKTEYE 374
Query: 698 ALIQEVISQSRARFNPSISMIKKCIEVLIDKQ 729
+ + + Q R + N I ++ + +++
Sbjct: 375 NKLHDELEQIRLKTNQEIDQLRNASREMYERE 406
>gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1
precursor [Homo sapiens]
Length = 513
Score = 30.8 bits (68), Expect = 4.8
Identities = 22/86 (25%), Positives = 37/86 (43%), Gaps = 6/86 (6%)
Query: 589 NNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSKR 648
N T SY E Q+ + +E++ + T+ +S +E D+ESS SLN + S
Sbjct: 367 NPDPTTSYVEDQEDSDSSEEDSSHTLSHS------KSESREEQADSESSESLNFSEESPE 420
Query: 649 TKFKITTSMQKDTPQEMEQTRSAVDE 674
+ +S Q+ S +E
Sbjct: 421 SPEDENSSSQEGLQSHSSSAESQSEE 446
>gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2
precursor [Homo sapiens]
Length = 497
Score = 30.8 bits (68), Expect = 4.8
Identities = 22/86 (25%), Positives = 37/86 (43%), Gaps = 6/86 (6%)
Query: 589 NNSETVSYKELQDSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSKR 648
N T SY E Q+ + +E++ + T+ +S +E D+ESS SLN + S
Sbjct: 351 NPDPTTSYVEDQEDSDSSEEDSSHTLSHS------KSESREEQADSESSESLNFSEESPE 404
Query: 649 TKFKITTSMQKDTPQEMEQTRSAVDE 674
+ +S Q+ S +E
Sbjct: 405 SPEDENSSSQEGLQSHSSSAESQSEE 430
>gi|50658071 phosphodiesterase 4D interacting protein isoform 5
[Homo sapiens]
Length = 1132
Score = 30.8 bits (68), Expect = 4.8
Identities = 40/163 (24%), Positives = 70/163 (42%), Gaps = 30/163 (18%)
Query: 141 ELALDMWRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVEQYKKKFPL 200
ELAL M + L +P+Q+ L +K+ G P + GV + F++
Sbjct: 289 ELALSMIKGLDYKPIQSPRGSRLPIPVKSSLPGAKPGPSMTDGVSSGFLN---------- 338
Query: 201 KFYQEIFESPFLTETGEYYKQEASNL--LQESNCSQYMEKVLGRLKDEEIRCRKY-LHPS 257
+ + ++++P Y E S+L L + C Y+ + + +E ++ +K H +
Sbjct: 339 RSLKPLYKTPV------SYPLELSDLQELWDDLCEDYLPLRVQPMTEELLKQQKLNSHET 392
Query: 258 SYTKVIHECQQRMVADHLQFL-----HAECHNIIRQEKKNDMA 295
+ T QQ + HL L E N I QEK N+M+
Sbjct: 393 TIT------QQSVSDSHLAELQEKIQQTEATNKILQEKLNEMS 429
>gi|93102364 SWAP-70 protein [Homo sapiens]
Length = 585
Score = 30.4 bits (67), Expect = 6.2
Identities = 34/143 (23%), Positives = 61/143 (42%), Gaps = 13/143 (9%)
Query: 597 KELQDSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTS 656
KELQ + + ++EL K L + + EK+ + + + +R K I
Sbjct: 342 KELQAANESKQQELEAVRKKLEEAASRAAEEEKKRLQTQVELQARFSTELEREKL-IRQQ 400
Query: 657 MQKDTPQ---EMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNP 713
M++ Q E+EQ V E MYL ++ +A + R +E + + +AR
Sbjct: 401 MEEQVAQKSSELEQYLQRVRELEDMYL-----KLQEALEDERQARQDEETVRKLQARLLE 455
Query: 714 SISMIKKCIEVLIDKQYIERSQA 736
S + +E K ++E+ QA
Sbjct: 456 EESSKRAELE----KWHLEQQQA 474
>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
Length = 3907
Score = 30.4 bits (67), Expect = 6.2
Identities = 26/120 (21%), Positives = 55/120 (45%), Gaps = 7/120 (5%)
Query: 598 ELQDSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFK--ITT 655
ELQ+ +E+ L + K S +E + + K ++F+ I
Sbjct: 361 ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQ 420
Query: 656 SMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSI 715
M+++T +++EQ R+ +DE MY Q + MK + +H A ++E+ ++ + ++
Sbjct: 421 RMEQETQRKLEQLRAELDE---MYGQQIVQ--MKQELIRQHMAQMEEMKTRHKGEMENAL 475
>gi|22538393 A-kinase anchor protein 9 isoform 3 [Homo sapiens]
Length = 3899
Score = 30.4 bits (67), Expect = 6.2
Identities = 26/120 (21%), Positives = 55/120 (45%), Gaps = 7/120 (5%)
Query: 598 ELQDSTQMNEKELTKTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFK--ITT 655
ELQ+ +E+ L + K S +E + + K ++F+ I
Sbjct: 361 ELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQ 420
Query: 656 SMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSI 715
M+++T +++EQ R+ +DE MY Q + MK + +H A ++E+ ++ + ++
Sbjct: 421 RMEQETQRKLEQLRAELDE---MYGQQIVQ--MKQELIRQHMAQMEEMKTRHKGEMENAL 475
>gi|14702171 DNA directed RNA polymerase II polypeptide C [Homo
sapiens]
Length = 275
Score = 30.4 bits (67), Expect = 6.2
Identities = 23/102 (22%), Positives = 49/102 (48%), Gaps = 4/102 (3%)
Query: 617 LLDVKMINHDSEKEDIDAESS--FSLNMNFSSKRTKFKITTSMQKDTPQEMEQTRSAVDE 674
++D + D E+ E S F+L++ + +T+ + + ++P+ + T D
Sbjct: 78 IVDKLQYSRDCTCEEFCPECSVEFTLDVRCNEDQTRHVTSRDLISNSPRVIPVTSRNRDN 137
Query: 675 DRKMYLQAAIVRIMKARK--VLRHNALIQEVISQSRARFNPS 714
D Y++ + I+K RK LR A ++ + A++NP+
Sbjct: 138 DPNDYVEQDDILIVKLRKGQELRLRAYAKKGFGKEHAKWNPT 179
>gi|118918407 spectrin repeat containing, nuclear envelope 2 isoform
5 [Homo sapiens]
Length = 6907
Score = 30.0 bits (66), Expect = 8.1
Identities = 61/327 (18%), Positives = 137/327 (41%), Gaps = 47/327 (14%)
Query: 147 WRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVE-QYKKKFPLKFYQE 205
WRKL+ + + + ++++ K D+ D + ++ + V + P + Q
Sbjct: 658 WRKLVSKTQLEMNLPLMIK--KQDQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQN 715
Query: 206 IFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHE 265
I + GE +++E + ++ +EK++G+++ E + L + E
Sbjct: 716 I-------KAGEKHEKENEEFTGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDDVDTSMEE 768
Query: 266 CQQRMVADHLQF--LHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEG 323
+ ++A F L A ++++ + +N +++ ++TGL IQE + +
Sbjct: 769 SLKHLIAKGSMFDELMARSEDMLQMDIQN-ISSQESFQHVLTTGLQAKIQEAKEKVQINV 827
Query: 324 LR---ATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYRE 380
++ A NLT + P L + +E K +L + ++ Q ++ RE
Sbjct: 828 VKLIAALKNLTDVS-PDLDIRLKMEESQK--ELESYMMRAQQ------------LLGQRE 872
Query: 381 PKSVCKAPELLAKYCDNLLKKSAKGMTE-----NEVEDRLTSFITVFKYIDDKDVFQKFY 435
EL++K+ + L+ + K + + E+++ +T I + +DV K+
Sbjct: 873 SPG-----ELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKW- 926
Query: 436 ARMLAKRLIHGLSMSMDSEEAMINKLK 462
+ L H LS+ + + I K K
Sbjct: 927 -----ESLHHELSLYVQQLKIDIEKGK 948
>gi|118918403 spectrin repeat containing, nuclear envelope 2 isoform
1 [Homo sapiens]
Length = 6885
Score = 30.0 bits (66), Expect = 8.1
Identities = 61/327 (18%), Positives = 137/327 (41%), Gaps = 47/327 (14%)
Query: 147 WRKLMVEPLQAILIRMLLREIKNDRGGEDPNQKVIHGVINSFVHVE-QYKKKFPLKFYQE 205
WRKL+ + + + ++++ K D+ D + ++ + V + P + Q
Sbjct: 658 WRKLVSKTQLEMNLPLMIK--KQDQPTFDNSGNILSKEEKATVEFSTDMSVELPENYNQN 715
Query: 206 IFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRCRKYLHPSSYTKVIHE 265
I + GE +++E + ++ +EK++G+++ E + L + E
Sbjct: 716 I-------KAGEKHEKENEEFTGQLKVAKDVEKLIGQVEIWEAEAKSVLDQDDVDTSMEE 768
Query: 266 CQQRMVADHLQF--LHAECHNIIRQEKKNDMANMYVLLRAVSTGLPHMIQELQNHIHDEG 323
+ ++A F L A ++++ + +N +++ ++TGL IQE + +
Sbjct: 769 SLKHLIAKGSMFDELMARSEDMLQMDIQN-ISSQESFQHVLTTGLQAKIQEAKEKVQINV 827
Query: 324 LR---ATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALDKALTSVVNYRE 380
++ A NLT + P L + +E K +L + ++ Q ++ RE
Sbjct: 828 VKLIAALKNLTDVS-PDLDIRLKMEESQK--ELESYMMRAQQ------------LLGQRE 872
Query: 381 PKSVCKAPELLAKYCDNLLKKSAKGMTE-----NEVEDRLTSFITVFKYIDDKDVFQKFY 435
EL++K+ + L+ + K + + E+++ +T I + +DV K+
Sbjct: 873 SPG-----ELISKHKEALIISNTKSLAKYLKAVEELKNNVTEDIKMSLEEKSRDVCAKW- 926
Query: 436 ARMLAKRLIHGLSMSMDSEEAMINKLK 462
+ L H LS+ + + I K K
Sbjct: 927 -----ESLHHELSLYVQQLKIDIEKGK 948
>gi|153791472 MAP/microtubule affinity-regulating kinase 1 [Homo
sapiens]
Length = 795
Score = 30.0 bits (66), Expect = 8.1
Identities = 26/101 (25%), Positives = 46/101 (45%), Gaps = 10/101 (9%)
Query: 601 DSTQMNEKELTKTIKSLLDVKMINHDSEK---EDIDAESSFSLNMNFSSKRTKFKITTS- 656
D TQ+N L K + + +K++NH + E I+ E + L M ++S F +
Sbjct: 92 DKTQLNPTSLQKLFREVRIMKILNHPNIVKLFEVIETEKTLYLVMEYASGGEVFDYLVAH 151
Query: 657 ---MQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVL 694
+K+ + Q SAV + Y+ + R +KA +L
Sbjct: 152 GRMKEKEARAKFRQIVSAVQYCHQKYI---VHRDLKAENLL 189
>gi|111548666 SNF2 histone linker PHD RING helicase isoform a [Homo
sapiens]
Length = 1687
Score = 30.0 bits (66), Expect = 8.1
Identities = 41/184 (22%), Positives = 74/184 (40%), Gaps = 17/184 (9%)
Query: 241 GRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMANMYVL 300
GRL++E + R++ T+V E QQ + + H + R+ N + V+
Sbjct: 1102 GRLEEEAKQLREHYMSKCNTEVA-EAQQALYP-----VQQTIHELQRKIHSNSPWWLNVI 1155
Query: 301 LRAVSTGLPH-MIQELQNHIHDEGLRATSNLTQENMPTLFVESV-LEVHGKFVQLINTVL 358
RA+ + ++Q ++N I + T L+ F+ + +E K +L+ +
Sbjct: 1156 HRAIEFTIDEELVQRVRNEITSNYKQQTGKLSMSEKGLQFLLTTQMEELNKCQKLVREAV 1215
Query: 359 NGDQHFMSALDKALTSVVNYREPKS------VCKAPELLAKYCDNLLKKSAKGMT---EN 409
+ S +V + R + CKA EL +Y L + KG T E
Sbjct: 1216 KNLEGPPSRNVIESATVCHLRPARLPLNCCVFCKADELFTEYESKLFSNTVKGQTAIFEE 1275
Query: 410 EVED 413
+ED
Sbjct: 1276 MIED 1279
>gi|27436873 SNF2 histone linker PHD RING helicase isoform b [Homo
sapiens]
Length = 1659
Score = 30.0 bits (66), Expect = 8.1
Identities = 41/184 (22%), Positives = 74/184 (40%), Gaps = 17/184 (9%)
Query: 241 GRLKDEEIRCRKYLHPSSYTKVIHECQQRMVADHLQFLHAECHNIIRQEKKNDMANMYVL 300
GRL++E + R++ T+V E QQ + + H + R+ N + V+
Sbjct: 1102 GRLEEEAKQLREHYMSKCNTEVA-EAQQALYP-----VQQTIHELQRKIHSNSPWWLNVI 1155
Query: 301 LRAVSTGLPH-MIQELQNHIHDEGLRATSNLTQENMPTLFVESV-LEVHGKFVQLINTVL 358
RA+ + ++Q ++N I + T L+ F+ + +E K +L+ +
Sbjct: 1156 HRAIEFTIDEELVQRVRNEITSNYKQQTGKLSMSEKGLQFLLTTQMEELNKCQKLVREAV 1215
Query: 359 NGDQHFMSALDKALTSVVNYREPKS------VCKAPELLAKYCDNLLKKSAKGMT---EN 409
+ S +V + R + CKA EL +Y L + KG T E
Sbjct: 1216 KNLEGPPSRNVIESATVCHLRPARLPLNCCVFCKADELFTEYESKLFSNTVKGQTAIFEE 1275
Query: 410 EVED 413
+ED
Sbjct: 1276 MIED 1279
>gi|150010552 FK506 binding protein 15, 133kDa [Homo sapiens]
Length = 1219
Score = 30.0 bits (66), Expect = 8.1
Identities = 25/100 (25%), Positives = 47/100 (47%), Gaps = 17/100 (17%)
Query: 598 ELQDSTQMNEKELT--KTIKSLLDVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITT 655
ELQ++++ + + K + L++K+ + + E D+ E SL N S ++ K
Sbjct: 696 ELQETSEQAQSKFKSEKQNRKQLELKVTSLEEELTDLRVEKE-SLEKNLSERKKK----- 749
Query: 656 SMQKDTPQEMEQTRSAVDEDRKMYLQAAIVRIMKARKVLR 695
+ QE Q +DE RK Y + + K R++L+
Sbjct: 750 -----SAQERSQAEEEIDEIRKSYQE----ELDKLRQLLK 780
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.133 0.380
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 24,794,661
Number of Sequences: 37866
Number of extensions: 1031665
Number of successful extensions: 2916
Number of sequences better than 10.0: 28
Number of HSP's better than 10.0 without gapping: 9
Number of HSP's successfully gapped in prelim test: 19
Number of HSP's that attempted gapping in prelim test: 2852
Number of HSP's gapped (non-prelim): 41
length of query: 745
length of database: 18,247,518
effective HSP length: 110
effective length of query: 635
effective length of database: 14,082,258
effective search space: 8942233830
effective search space used: 8942233830
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 66 (30.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.