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Search of human proteins with 194294521
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
(1697 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194294521 intersectin 2 isoform 1 [Homo sapiens] 3386 0.0
gi|194294523 intersectin 2 isoform 3 [Homo sapiens] 3318 0.0
gi|194294525 intersectin 2 isoform 2 [Homo sapiens] 2463 0.0
gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens] 1951 0.0
gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens] 1155 0.0
gi|10864047 epidermal growth factor receptor pathway substrate 1... 151 5e-36
gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo... 127 1e-28
gi|4503593 epidermal growth factor receptor pathway substrate 15... 125 3e-28
gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens] 125 3e-28
gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens] 125 3e-28
gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens] 125 3e-28
gi|148746195 trichohyalin [Homo sapiens] 121 7e-27
gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 120 1e-26
gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 120 1e-26
gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [... 114 6e-25
gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [... 114 6e-25
gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [... 114 6e-25
gi|194473700 Src homology 3 domain-containing guanine nucleotide... 112 3e-24
gi|23308553 spermatogenesis associated 13 [Homo sapiens] 109 3e-23
gi|163792208 Rho guanine exchange factor 16 [Homo sapiens] 109 3e-23
gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 ... 107 1e-22
gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 ... 107 1e-22
gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [H... 107 1e-22
gi|166064038 PAK-interacting exchange factor beta isoform a [Hom... 106 2e-22
gi|166064036 PAK-interacting exchange factor beta isoform d [Hom... 106 2e-22
gi|166064034 PAK-interacting exchange factor beta isoform c [Hom... 106 2e-22
gi|22027528 PAK-interacting exchange factor beta isoform b [Homo... 106 2e-22
gi|4505573 PAK-interacting exchange factor beta isoform a [Homo ... 106 2e-22
gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 ... 105 5e-22
gi|19923327 neuroepithelial cell transforming gene 1 isoform 2 [... 105 5e-22
>gi|194294521 intersectin 2 isoform 1 [Homo sapiens]
Length = 1697
Score = 3386 bits (8780), Expect = 0.0
Identities = 1697/1697 (100%), Positives = 1697/1697 (100%)
Query: 1 MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA 60
MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA
Sbjct: 1 MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA 60
Query: 61 EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG 120
EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG
Sbjct: 61 EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG 120
Query: 121 SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI 180
SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI
Sbjct: 121 SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI 180
Query: 181 PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV 240
PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV
Sbjct: 181 PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV 240
Query: 241 PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE 300
PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE
Sbjct: 241 PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE 300
Query: 301 EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP 360
EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP
Sbjct: 301 EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP 360
Query: 361 VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL 420
VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL
Sbjct: 361 VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL 420
Query: 421 ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE
Sbjct: 421 ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
Query: 481 IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL 540
IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL
Sbjct: 481 IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL 540
Query: 541 QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD 600
QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD
Sbjct: 541 QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD 600
Query: 601 ALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLA 660
ALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLA
Sbjct: 601 ALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLA 660
Query: 661 LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ 720
LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ
Sbjct: 661 LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ 720
Query: 721 EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS 780
EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS
Sbjct: 721 EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS 780
Query: 781 GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA 840
GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA
Sbjct: 781 GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA 840
Query: 841 TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN 900
TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN
Sbjct: 841 TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN 900
Query: 901 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK 960
LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK
Sbjct: 901 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK 960
Query: 961 REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG 1020
REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG
Sbjct: 961 REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG 1020
Query: 1021 SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI 1080
SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI
Sbjct: 1021 SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI 1080
Query: 1081 LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA 1140
LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA
Sbjct: 1081 LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA 1140
Query: 1141 NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL 1200
NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL
Sbjct: 1141 NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL 1200
Query: 1201 DTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKEL 1260
DTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKEL
Sbjct: 1201 DTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKEL 1260
Query: 1261 IMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTD 1320
IMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTD
Sbjct: 1261 IMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTD 1320
Query: 1321 EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL 1380
EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL
Sbjct: 1321 EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL 1380
Query: 1381 ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGK 1440
ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGK
Sbjct: 1381 ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGK 1440
Query: 1441 LYKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLV 1500
LYKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLV
Sbjct: 1441 LYKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLV 1500
Query: 1501 KLPTDPSSDEPVFHISHIDRVYTLRTDNINERTAWVQKIKAASEQYIDTEKKKREKAYQA 1560
KLPTDPSSDEPVFHISHIDRVYTLRTDNINERTAWVQKIKAASEQYIDTEKKKREKAYQA
Sbjct: 1501 KLPTDPSSDEPVFHISHIDRVYTLRTDNINERTAWVQKIKAASEQYIDTEKKKREKAYQA 1560
Query: 1561 RSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNC 1620
RSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNC
Sbjct: 1561 RSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNC 1620
Query: 1621 QFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQESKGPMTRRLLLHEVPTG 1680
QFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQESKGPMTRRLLLHEVPTG
Sbjct: 1621 QFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQESKGPMTRRLLLHEVPTG 1680
Query: 1681 EVWVRFDLQLFEQKTLL 1697
EVWVRFDLQLFEQKTLL
Sbjct: 1681 EVWVRFDLQLFEQKTLL 1697
>gi|194294523 intersectin 2 isoform 3 [Homo sapiens]
Length = 1670
Score = 3318 bits (8602), Expect = 0.0
Identities = 1670/1697 (98%), Positives = 1670/1697 (98%), Gaps = 27/1697 (1%)
Query: 1 MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA 60
MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA
Sbjct: 1 MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA 60
Query: 61 EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG 120
EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG
Sbjct: 61 EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG 120
Query: 121 SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI 180
SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI
Sbjct: 121 SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI 180
Query: 181 PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV 240
PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV
Sbjct: 181 PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV 240
Query: 241 PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE 300
PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE
Sbjct: 241 PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE 300
Query: 301 EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP 360
EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP
Sbjct: 301 EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP 360
Query: 361 VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL 420
VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL
Sbjct: 361 VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL 420
Query: 421 ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE
Sbjct: 421 ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
Query: 481 IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL 540
IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL
Sbjct: 481 IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL 540
Query: 541 QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD 600
QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD
Sbjct: 541 QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD 600
Query: 601 ALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLA 660
ALEKETASKLSEMDSFNNQLK ELRETYNTQQLA
Sbjct: 601 ALEKETASKLSEMDSFNNQLK---------------------------ELRETYNTQQLA 633
Query: 661 LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ 720
LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ
Sbjct: 634 LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ 693
Query: 721 EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS 780
EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS
Sbjct: 694 EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS 753
Query: 781 GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA 840
GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA
Sbjct: 754 GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA 813
Query: 841 TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN 900
TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN
Sbjct: 814 TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN 873
Query: 901 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK 960
LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK
Sbjct: 874 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK 933
Query: 961 REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG 1020
REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG
Sbjct: 934 REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG 993
Query: 1021 SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI 1080
SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI
Sbjct: 994 SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI 1053
Query: 1081 LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA 1140
LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA
Sbjct: 1054 LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA 1113
Query: 1141 NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL 1200
NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL
Sbjct: 1114 NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL 1173
Query: 1201 DTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKEL 1260
DTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKEL
Sbjct: 1174 DTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKEL 1233
Query: 1261 IMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTD 1320
IMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTD
Sbjct: 1234 IMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTD 1293
Query: 1321 EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL 1380
EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL
Sbjct: 1294 EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL 1353
Query: 1381 ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGK 1440
ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGK
Sbjct: 1354 ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGK 1413
Query: 1441 LYKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLV 1500
LYKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLV
Sbjct: 1414 LYKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLV 1473
Query: 1501 KLPTDPSSDEPVFHISHIDRVYTLRTDNINERTAWVQKIKAASEQYIDTEKKKREKAYQA 1560
KLPTDPSSDEPVFHISHIDRVYTLRTDNINERTAWVQKIKAASEQYIDTEKKKREKAYQA
Sbjct: 1474 KLPTDPSSDEPVFHISHIDRVYTLRTDNINERTAWVQKIKAASEQYIDTEKKKREKAYQA 1533
Query: 1561 RSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNC 1620
RSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNC
Sbjct: 1534 RSQKTSGIGRLMVHVIEATELKACKPNGKSNPYCEISMGSQSYTTRTIQDTLNPKWNFNC 1593
Query: 1621 QFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQESKGPMTRRLLLHEVPTG 1680
QFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQESKGPMTRRLLLHEVPTG
Sbjct: 1594 QFFIKDLYQDVLCLTLFDRDQFSPDDFLGRTEIPVAKIRTEQESKGPMTRRLLLHEVPTG 1653
Query: 1681 EVWVRFDLQLFEQKTLL 1697
EVWVRFDLQLFEQKTLL
Sbjct: 1654 EVWVRFDLQLFEQKTLL 1670
>gi|194294525 intersectin 2 isoform 2 [Homo sapiens]
Length = 1249
Score = 2463 bits (6384), Expect = 0.0
Identities = 1236/1242 (99%), Positives = 1238/1242 (99%)
Query: 1 MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA 60
MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA
Sbjct: 1 MMAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLA 60
Query: 61 EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG 120
EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG
Sbjct: 61 EIWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMG 120
Query: 121 SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI 180
SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI
Sbjct: 121 SMPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPI 180
Query: 181 PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV 240
PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV
Sbjct: 181 PYSSSTLPHGSSYSLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAV 240
Query: 241 PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE 300
PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE
Sbjct: 241 PQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAE 300
Query: 301 EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP 360
EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP
Sbjct: 301 EFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLP 360
Query: 361 VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL 420
VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL
Sbjct: 361 VTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQL 420
Query: 421 ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE
Sbjct: 421 ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQELLNQKNREQEE 480
Query: 481 IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL 540
IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL
Sbjct: 481 IVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQL 540
Query: 541 QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD 600
QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD
Sbjct: 541 QQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLD 600
Query: 601 ALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLA 660
ALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLA
Sbjct: 601 ALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLA 660
Query: 661 LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ 720
LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ
Sbjct: 661 LEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQ 720
Query: 721 EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS 780
EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS
Sbjct: 721 EEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNS 780
Query: 781 GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA 840
GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA
Sbjct: 781 GDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPKKALLPPTVSLSA 840
Query: 841 TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN 900
TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN
Sbjct: 841 TSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPGSVSPIHGQGQVVEN 900
Query: 901 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK 960
LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK
Sbjct: 901 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGWFPKSYVKIIPGSEVK 960
Query: 961 REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG 1020
REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG
Sbjct: 961 REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQKDGEWWTG 1020
Query: 1021 SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI 1080
SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI
Sbjct: 1021 SIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLI 1080
Query: 1081 LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA 1140
LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA
Sbjct: 1081 LILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSERATPAFHPVCQVIAMYDYAA 1140
Query: 1141 NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL 1200
NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL
Sbjct: 1141 NNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTL 1200
Query: 1201 DTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAES 1242
DTMQPIERKRQGYIHELIQTEERYMADLQLVVEV + +A S
Sbjct: 1201 DTMQPIERKRQGYIHELIQTEERYMADLQLVVEVRRLLLASS 1242
>gi|47717123 intersectin 1 isoform ITSN-l [Homo sapiens]
Length = 1721
Score = 1951 bits (5055), Expect = 0.0
Identities = 1049/1783 (58%), Positives = 1296/1783 (72%), Gaps = 154/1783 (8%)
Query: 2 MAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAE 61
MAQFPT G ++WAIT EER KHD+QF +LKP G+ITGDQARNFF QSGLP PVLA+
Sbjct: 1 MAQFPTPFGGSLDIWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQ 60
Query: 62 IWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGS 121
IWAL+D+N DG+MDQ EFSIAMKLIKLKLQG QLP LPP+MKQ P+ A FGMG
Sbjct: 61 IWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPA-FGMGG 119
Query: 122 MPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLP---NGTASLIQPL 178
+ ++ P+T+++ G+ +P + M LV SV T+++P NG +IQPL
Sbjct: 120 IASMP---------PLTAVAPVPMGS-IPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPL 169
Query: 179 P-IPYSSSTLPHGSSYSLMMGGFG-GASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTS 236
P + ++TLP SS+S G +QKAQS D+ S +
Sbjct: 170 PAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSF-DVASVPPVA--------------- 213
Query: 237 EWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQ 296
EWAVPQ +RLKYRQ FN+ DK+MSG+L+G QAR L+QS+L Q QLA+IW L+D+D DG+
Sbjct: 214 EWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGK 273
Query: 297 LKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFR---GGKQIDSINGT-----LPSYQ 348
L AEEFILAMHL D+A +GQPLP LPPE +PPSFR G I I+ T LP
Sbjct: 274 LTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEP 333
Query: 349 KMQEEEPQ--KKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWER 406
+++E+ Q KKLPVTFEDK++ N+ERGN+ELEKRRQAL+EQQ++E ER AQ E+ E ER
Sbjct: 334 VLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQER 393
Query: 407 KQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIR 466
K+RE QEQE K+QLELEK+LEKQRELERQREEERRK+IERREAAK+ELERQR+LEWER R
Sbjct: 394 KERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNR 453
Query: 467 RQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVL 526
RQELLNQ+N+EQE+IV L +KKK L ELEALN K Q+ G+LQD+R + TQ+ E+E
Sbjct: 454 RQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIEST 513
Query: 527 DKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTP-DSGVSLLHKKS 585
+K +L I EI LQQ+LQE Q L L+PEKQ+LN+++K +Q ++ DS V+L K++
Sbjct: 514 NKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTL--KRA 571
Query: 586 LEKEELC-QRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLF 644
LE +EL Q L++QLD +EKET SKL E+D FNNQLK
Sbjct: 572 LEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQLK----------------------- 608
Query: 645 LLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLW 704
ELRE +N QQL ++ + +R K KE ERK +EL ++K +EA R+A++ ++ W
Sbjct: 609 ----ELREIHNKQQLQKQKSMEAERLKQKEQERKIIELEKQK---EEAQRRAQE-RDKQW 660
Query: 705 KENLRKEEE--------EKQKRLQEEKTQEKIQEEERKAE----------EKQRKDKDTL 746
E++++E+E E++K +EE ++K EE+ K E + Q K +
Sbjct: 661 LEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAV 720
Query: 747 KAE----EKKRETASV-----LVNYRALYPFEARNHDEMSFNSGDIIQV-----DEKTVG 792
+A EK T S +V YRALYPFE+R+HDE++ GDI+ V DE G
Sbjct: 721 QAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTG 780
Query: 793 EPGWLYGSFQGNFGWFPCNYVEKMPSSE----------NEKAVSPKKALLPPTVSLSATS 842
EPGWL G +G GWFP NY EK+P +E + A +PK AL L+ TS
Sbjct: 781 EPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTS 840
Query: 843 T-------------SSEPLSSNQPASVTDYQN-VSFSNLTVNTSWQ--KKSAFTRTVSPG 886
+ S+ P S+N+ ++ + +LTV ++ Q ++SAFT + G
Sbjct: 841 SEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATG 900
Query: 887 SV-SPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGW 945
S SP+ GQG+ VE L+AQAL W AKKDNHLNF+K+D+ITVLEQQ+ WWFGEV G +GW
Sbjct: 901 SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGW 960
Query: 946 FPKSYVKIIPGSEVKR--------EEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEP 997
FPKSYVK+I G K E P +L + P + GEE+IA+Y Y S E
Sbjct: 961 FPKSYVKLISGPIRKSTSMDSGSSESPASLKRVAS--PAAKPVVSGEEFIAMYTYESSEQ 1018
Query: 998 GDLTFTEGEEILVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEI 1057
GDLTF +G+ ILVT+KDG+WWTG++GD++G+FPSNYV+ KD E G+A K+G+ KKPEI
Sbjct: 1019 GDLTFQQGDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEI 1078
Query: 1058 AQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGP 1117
AQV ++Y A+G EQL+LAPGQLILI KKN GWW+GELQARGKKRQ GWFPA++VKLL P
Sbjct: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSP 1138
Query: 1118 SSERATPAFHP-------VCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEIN 1170
+ + TP P VCQVI MYDY A N+DEL+F+KGQ+INV+NK+DPDWW+GE+N
Sbjct: 1139 GTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN 1198
Query: 1171 GVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQL 1230
G GLFPSNYVK+TTD DPSQQWC+DL LD + P ERKRQGYIHELI TEE Y+ DLQL
Sbjct: 1199 GQVGLFPSNYVKLTTDMDPSQQWCSDLHLLDMLTPTERKRQGYIHELIVTEENYVNDLQL 1258
Query: 1231 VVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDI 1290
V E+FQK + ES LTE E+A+IFVNWKELIM N KLLKALRVRKK GEKMPV+MIGDI
Sbjct: 1259 VTEIFQKPLMESELLTEKEVAMIFVNWKELIMCNIKLLKALRVRKKMSGEKMPVKMIGDI 1318
Query: 1291 LAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKP 1350
L+A+L HMQ YIRFCS QLNGAAL+QQKTDE DFKEF+K+LA DPRCKGMPLSSF+LKP
Sbjct: 1319 LSAQLPHMQPYIRFCSRQLNGAALIQQKTDEAPDFKEFVKRLAMDPRCKGMPLSSFILKP 1378
Query: 1351 MQRITRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQA 1410
MQR+TRYPL+I++ILENTPE+H DHS LK ALE+AEELCSQVNEGVREKENSDRLEWIQA
Sbjct: 1379 MQRVTRYPLIIKNILENTPENHPDHSHLKHALEKAEELCSQVNEGVREKENSDRLEWIQA 1438
Query: 1411 HVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYKTKSNKELHGFLFNDFLLLTYMVKQFAV 1470
HVQCEGL+EQL+FNS+TNCLGPRK LHSGKLYK KSNKEL+GFLFNDFLLLT + K
Sbjct: 1439 HVQCEGLSEQLVFNSVTNCLGPRKFLHSGKLYKAKSNKELYGFLFNDFLLLTQITKPLG- 1497
Query: 1471 SSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTDNIN 1530
SSG++K+FS KSN Q+KMYKTPIFLNEVLVKLPTDPS DEP+FHISHIDRVYTLR ++IN
Sbjct: 1498 SSGTDKVFSPKSNLQYKMYKTPIFLNEVLVKLPTDPSGDEPIFHISHIDRVYTLRAESIN 1557
Query: 1531 ERTAWVQKIKAASEQYIDTEKKKREKAYQARSQKTSGIGRLMVHVIEATELKACKPNGKS 1590
ERTAWVQKIKAASE YI+TEKKKREKAY RSQ+ +GIGRLMV+V+E ELK C+ +GKS
Sbjct: 1558 ERTAWVQKIKAASELYIETEKKKREKAYLVRSQRATGIGRLMVNVVEGIELKPCRSHGKS 1617
Query: 1591 NPYCEISMGSQSYTTRTIQDTLNPKWNFNCQFFIKDLYQDVLCLTLFDRDQFSPDDFLGR 1650
NPYCE++MGSQ + T+TIQDTLNPKWN NCQFFI+DL Q+VLC+T+F+RDQFSPDDFLGR
Sbjct: 1618 NPYCEVTMGSQCHITKTIQDTLNPKWNSNCQFFIRDLEQEVLCITVFERDQFSPDDFLGR 1677
Query: 1651 TEIPVAKIRTEQESKGPMTRRLLLHEVPTGEVWVRFDLQLFEQ 1693
TEI VA I+ +Q SKGP+T+ LLLHEVPTGE+ VR DLQLF++
Sbjct: 1678 TEIRVADIKKDQGSKGPVTKCLLLHEVPTGEIVVRLDLQLFDE 1720
>gi|47717125 intersectin 1 isoform ITSN-s [Homo sapiens]
Length = 1220
Score = 1155 bits (2988), Expect = 0.0
Identities = 662/1282 (51%), Positives = 852/1282 (66%), Gaps = 153/1282 (11%)
Query: 2 MAQFPTAMNGGPNMWAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAE 61
MAQFPT G ++WAIT EER KHD+QF +LKP G+ITGDQARNFF QSGLP PVLA+
Sbjct: 1 MAQFPTPFGGSLDIWAITVEERAKHDQQFHSLKPISGFITGDQARNFFFQSGLPQPVLAQ 60
Query: 62 IWALSDLNKDGKMDQQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGS 121
IWAL+D+N DG+MDQ EFSIAMKLIKLKLQG QLP LPP+MKQ P+ A FGMG
Sbjct: 61 IWALADMNNDGRMDQVEFSIAMKLIKLKLQGYQLPSALPPVMKQQPVAISSAPA-FGMGG 119
Query: 122 MPNLSIPQPLPPAAPITSLSSATSGTNLPPLMMPTPLVPSVSTSSLP---NGTASLIQPL 178
+ ++ P+T+++ G+ +P + M LV SV T+++P NG +IQPL
Sbjct: 120 IASMP---------PLTAVAPVPMGS-IPVVGMSPTLVSSVPTAAVPPLANGAPPVIQPL 169
Query: 179 P-IPYSSSTLPHGSSYSLMMGGFG-GASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTS 236
P + ++TLP SS+S G +QKAQS D+ S +
Sbjct: 170 PAFAHPAATLPKSSSFSRSGPGSQLNTKLQKAQSF-DVASVPPVA--------------- 213
Query: 237 EWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQ 296
EWAVPQ +RLKYRQ FN+ DK+MSG+L+G QAR L+QS+L Q QLA+IW L+D+D DG+
Sbjct: 214 EWAVPQSSRLKYRQLFNSHDKTMSGHLTGPQARTILMQSSLPQAQLASIWNLSDIDQDGK 273
Query: 297 LKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFR---GGKQIDSINGT-----LPSYQ 348
L AEEFILAMHL D+A +GQPLP LPPE +PPSFR G I I+ T LP
Sbjct: 274 LTAEEFILAMHLIDVAMSGQPLPPVLPPEYIPPSFRRVRSGSGISVISSTSVDQRLPEEP 333
Query: 349 KMQEEEPQ--KKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWER 406
+++E+ Q KKLPVTFEDK++ N+ERGN+ELEKRRQAL+EQQ++E ER AQ E+ E ER
Sbjct: 334 VLEDEQQQLEKKLPVTFEDKKRENFERGNLELEKRRQALLEQQRKEQERLAQLERAEQER 393
Query: 407 KQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIR 466
K+RE QEQE K+QLELEK+LEKQRELERQREEERRK+IERREAAK+ELERQR+LEWER R
Sbjct: 394 KERERQEQERKRQLELEKQLEKQRELERQREEERRKEIERREAAKRELERQRQLEWERNR 453
Query: 467 RQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVL 526
RQELLNQ+N+EQE+IV L +KKK L ELEALN K Q+ G+LQD+R + TQ+ E+E
Sbjct: 454 RQELLNQRNKEQEDIVVLKAKKKTLEFELEALNDKKHQLEGKLQDIRCRLTTQRQEIEST 513
Query: 527 DKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNT-PDSGVSLLHKKS 585
+K +L I EI LQQ+LQE Q L L+PEKQ+LN+++K +Q ++ DS V+L K++
Sbjct: 514 NKSRELRIAEITHLQQQLQESQQMLGRLIPEKQILNDQLKQVQQNSLHRDSLVTL--KRA 571
Query: 586 LEKEELC-QRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLF 644
LE +EL Q L++QLD +EKET SKL E+D FNNQ
Sbjct: 572 LEAKELARQHLRDQLDEVEKETRSKLQEIDIFNNQ------------------------- 606
Query: 645 LLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLW 704
LKELRE +N QQL ++ + +R K KE ERK +EL +K ++EA R+A Q ++ W
Sbjct: 607 --LKELREIHNKQQLQKQKSMEAERLKQKEQERKIIEL---EKQKEEAQRRA-QERDKQW 660
Query: 705 KENLRKEEE--------EKQKRLQEEKTQEKIQEEERKAE----------EKQRKDKDTL 746
E++++E+E E++K +EE ++K EE+ K E + Q K +
Sbjct: 661 LEHVQQEDEHQRPRKLHEEEKLKREESVKKKDGEEKGKQEAQDKLGRLFHQHQEPAKPAV 720
Query: 747 KA----EEKKRETASV-----LVNYRALYPFEARNHDEMSFNSGDIIQ-----VDEKTVG 792
+A EK T S +V YRALYPFE+R+HDE++ GDI+ VDE G
Sbjct: 721 QAPWSTAEKGPLTISAQENVKVVYYRALYPFESRSHDEITIQPGDIVMVKGEWVDESQTG 780
Query: 793 EPGWLYGSFQGNFGWFPCNYVEKMPSSE----------NEKAVSPKKALLPPTVSLSATS 842
EPGWL G +G GWFP NY EK+P +E + A +PK AL L+ TS
Sbjct: 781 EPGWLGGELKGKTGWFPANYAEKIPENEVPAPVKPVTDSTSAPAPKLALRETPAPLAVTS 840
Query: 843 -------------TSSEPLSSNQPASVTDYQN-VSFSNLTVNTSWQ--KKSAFTRTVSPG 886
+S+ P S+N+ ++ + +LTV ++ Q ++SAFT + G
Sbjct: 841 SEPSTTPNNWADFSSTWPTSTNEKPETDNWDAWAAQPSLTVPSAGQLRQRSAFTPATATG 900
Query: 887 -SVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQENWWFGEVHGGRGW 945
S SP+ GQG+ VE L+AQAL W AKKDNHLNF+K+D+ITVLEQQ+ WWFGEV G +GW
Sbjct: 901 SSPSPVLGQGEKVEGLQAQALYPWRAKKDNHLNFNKNDVITVLEQQDMWWFGEVQGQKGW 960
Query: 946 FPKSYVKIIPGSEVK--------REEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEP 997
FPKSYVK+I G K E P +L + P + GEE+IA+Y Y S E
Sbjct: 961 FPKSYVKLISGPIRKSTSMDSGSSESPASLKRVAS--PAAKPVVSGEEFIAMYTYESSEQ 1018
Query: 998 GDLTFTEGEEILVTQKDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSASKSGASNKKPEI 1057
GDLTF +G+ ILVT+KDG+WWTG++GD++G+FPSNYV+ KD E G+A K+G+ KKPEI
Sbjct: 1019 GDLTFQQGDVILVTKKDGDWWTGTVGDKAGVFPSNYVRLKDSEGSGTAGKTGSLGKKPEI 1078
Query: 1058 AQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGP 1117
AQV ++Y A+G EQL+LAPGQLILI KKN GWW+GELQARGKKRQ GWFPA++VKLL P
Sbjct: 1079 AQVIASYTATGPEQLTLAPGQLILIRKKNPGGWWEGELQARGKKRQIGWFPANYVKLLSP 1138
Query: 1118 SSERATPAFHP-------VCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEIN 1170
+ + TP P VCQVI MYDY A N+DEL+F+KGQ+INV+NK+DPDWW+GE+N
Sbjct: 1139 GTSKITPTEPPKSTALAAVCQVIGMYDYTAQNDDELAFNKGQIINVLNKEDPDWWKGEVN 1198
Query: 1171 GVTGLFPSNYVKMTTDSDPSQQ 1192
G GLFPSNYVK+TTD DPSQQ
Sbjct: 1199 GQVGLFPSNYVKLTTDMDPSQQ 1220
>gi|10864047 epidermal growth factor receptor pathway substrate
15-like 1 [Homo sapiens]
Length = 864
Score = 151 bits (382), Expect = 5e-36
Identities = 143/547 (26%), Positives = 246/547 (44%), Gaps = 110/547 (20%)
Query: 16 WAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMD 75
WA+ EE+ K D F++L P G ++GD+ + + S LP VL +W LSD++KDG +D
Sbjct: 121 WAVRVEEKAKFDGIFESLLPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLSDIDKDGHLD 180
Query: 76 QQEFSIAMKLIKLKLQGQQLPVVLPPIMKQPPMFSPLISARFGMGSMPNLSIPQPLPPAA 135
+ EF++AM L+ L+ +P+P A
Sbjct: 181 RDEFAVAMHLVYRALE------------------------------------KEPVPSA- 203
Query: 136 PITSLSSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPIPYSS--STLPHGSSY 193
LPP ++P PS ++ G ++ P P S ST HGS
Sbjct: 204 -------------LPPSLIP----PSKRKKTVFPGAVPVLPASPPPKDSLRSTPSHGSVS 246
Query: 194 SLMMGGFGGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFN 253
SL S+ S S SL P T W VP ++++ + F
Sbjct: 247 SL-------------------NSTGSLSPKHSLKQTQP---TVNWVVPVADKMRFDEIFL 284
Query: 254 TLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMH-LTDMA 312
D + GY+SG + + + S L+Q LA IW LAD G+L ++F LAM+ +
Sbjct: 285 KTDLDLDGYVSGQEVKEIFMHSGLTQNLLAHIWALADTRQTGKLSKDQFALAMYFIQQKV 344
Query: 313 KAGQPLPLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYE 372
G P L P++VPPS RG DS +G+L S E K+L ++ + E
Sbjct: 345 SKGIDPPQVLSPDMVPPSERGTPGPDS-SGSLGS----GEFTGVKELDDISQEIAQLQRE 399
Query: 373 RGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQREL 432
+ ++E + R + E+ R+ + Q+ + + +R+ LQE E +KQ + + RL+ E+
Sbjct: 400 KYSLEQDIREK---EEAIRQKTSEVQELQNDLDRETSSLQELEAQKQ-DAQDRLD---EM 452
Query: 433 ERQREEERRKDIERREAAKQELERQRRLEWE-RIRRQELLNQK---NREQEEIVRLNSKK 488
++Q+ + R + R+ + E + L+ + + + +L +Q+ NR + E+ RL ++
Sbjct: 453 DQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQEE 512
Query: 489 KNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQE----L 544
L ++A GR+Q + K + T+ E+ Q ++ ++ + +QE L
Sbjct: 513 TQLEQSIQA---------GRVQLETIIKSLKSTQDEI--NQARSKLSQLHESRQEAHRSL 561
Query: 545 QEYQNKL 551
++Y L
Sbjct: 562 EQYDQVL 568
Score = 75.1 bits (183), Expect = 5e-13
Identities = 39/103 (37%), Positives = 58/103 (56%), Gaps = 1/103 (0%)
Query: 230 SPKTGTSEWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLA 289
+P + + WAV + K+ F +L ++G LSG + + L+ S L L +W L+
Sbjct: 113 TPPSAEAHWAVRVEEKAKFDGIFESL-LPINGLLSGDKVKPVLMNSKLPLDVLGRVWDLS 171
Query: 290 DVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFR 332
D+D DG L +EF +AMHL A +P+P LPP L+PPS R
Sbjct: 172 DIDKDGHLDRDEFAVAMHLVYRALEKEPVPSALPPSLIPPSKR 214
Score = 47.8 bits (112), Expect = 9e-05
Identities = 49/209 (23%), Positives = 92/209 (44%), Gaps = 23/209 (11%)
Query: 442 KDIERREAAKQELERQRRLEWERIRR-----QELLNQKNREQEEIVRLNSKKKNLHLELE 496
++I + + K LE+ R + E IR+ QEL N +RE + L ++K++ L+
Sbjct: 391 QEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDRLD 450
Query: 497 ALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVP 556
++ + ++ L DVR K Q + + L Q + ++K + +L +++L L
Sbjct: 451 EMDQQKAKLRDMLSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNRLQQ 510
Query: 557 EKQLLNER-----------IKNMQFS----NTPDSGVSLLHKKSLEKEELCQRLKEQLDA 601
E+ L + IK+++ + N S +S LH+ E ++ + LD
Sbjct: 511 EETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQYDQVLDG 570
Query: 602 LEKET---ASKLSEMDSFNNQLKCGNMDD 627
+ + LSE S + G MDD
Sbjct: 571 AHGASLTDLANLSEGVSLAERGSFGAMDD 599
Score = 45.1 bits (105), Expect = 6e-04
Identities = 27/85 (31%), Positives = 43/85 (50%), Gaps = 1/85 (1%)
Query: 248 YRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMH 307
Y + +D + +G + +A L +S LS L IW LAD +G G L + F +A+
Sbjct: 19 YESYYKQVDPAYTGRVGASEAALFLKKSGLSDIILGKIWDLADPEGKGFLDKQGFYVALR 78
Query: 308 LTDMAKAGQPLPLT-LPPELVPPSF 331
L A++G + L+ L + PP F
Sbjct: 79 LVACAQSGHEVTLSNLNLSMPPPKF 103
Score = 39.3 bits (90), Expect = 0.033
Identities = 33/176 (18%), Positives = 86/176 (48%), Gaps = 4/176 (2%)
Query: 505 ISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNER 564
IS + ++ +K + + ++ ++ + E+++LQ +L + L L +KQ +R
Sbjct: 389 ISQEIAQLQREKYSLEQDIREKEEAIRQKTSEVQELQNDLDRETSSLQELEAQKQDAQDR 448
Query: 565 IKNM--QFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKC 622
+ M Q + D +S + +K ++ ++ LK Q+ + E + S+ +++ ++L
Sbjct: 449 LDEMDQQKAKLRDM-LSDVRQKCQDETQMISSLKTQIQSQESDLKSQEDDLNRAKSELNR 507
Query: 623 GNMDDSVL-QCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIER 677
+++ L Q + + L + LK ++ N + L QL++ +++ + +E+
Sbjct: 508 LQQEETQLEQSIQAGRVQLETIIKSLKSTQDEINQARSKLSQLHESRQEAHRSLEQ 563
>gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo
sapiens]
Length = 1544
Score = 127 bits (318), Expect = 1e-28
Identities = 105/368 (28%), Positives = 185/368 (50%), Gaps = 32/368 (8%)
Query: 1189 PSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEG 1248
P+ Q + L ++P E KRQ I+EL TE ++ L+++ +VF +R++ G L+
Sbjct: 767 PNWQQLVSREVLLGLKPCEIKRQEVINELFYTERAHVRTLKVLDQVFYQRVSREGILSPS 826
Query: 1249 EMALIFVNWKELIMSNTKL---LKALRVRKKTGGEKMPVQMIGDILAA--------ELSH 1297
E+ IF N ++++ + L +KA+R R +T + IG+ L +L H
Sbjct: 827 ELRKIFSNLEDILQLHIGLNEQMKAVRKRNETS----VIDQIGEDLLTWFSGPGEEKLKH 882
Query: 1298 MQAYIRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRY 1357
A FCS Q +++ + +D+ F+ F++ S+P C+ + L + MQR+T+Y
Sbjct: 883 AAA--TFCSNQPFALEMIKSRQKKDSRFQTFVQDAESNPLCRRLQLKDIIPTQMQRLTKY 940
Query: 1358 PLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEG- 1416
PLL+ +I + T E + +K A + ++ + VN+ V+E EN RLE Q +
Sbjct: 941 PLLLDNIAKYT-EWPTEREKVKKAADHCRQILNYVNQAVKEAENKQRLEDYQRRLDTSSL 999
Query: 1417 -LAEQLIFNSLTNC-LGPRKLLHSGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQFAVS 1471
L+E L N L RK++H G L +K +K +L+ L D L+L V
Sbjct: 1000 KLSEYPNVEELRNLDLTKRKMIHEGPLVWKVNRDKTIDLYTLLLEDILVLLQKQDDRLVL 1059
Query: 1472 SGSEKLFSSKSNAQFKMYKTPIFLNEVLVK-LPTDPSSDEPVFHISHID---RVYTLRTD 1527
K+ +S ++++ + I L+ VLV+ + TD ++ +F IS D ++Y L
Sbjct: 1060 RCHSKILASTADSK-HTFSPVIKLSTVLVRQVATD---NKALFVISMSDNGAQIYELVAQ 1115
Query: 1528 NINERTAW 1535
++E+T W
Sbjct: 1116 TVSEKTVW 1123
>gi|4503593 epidermal growth factor receptor pathway substrate 15
isoform A [Homo sapiens]
Length = 896
Score = 125 bits (314), Expect = 3e-28
Identities = 131/526 (24%), Positives = 224/526 (42%), Gaps = 52/526 (9%)
Query: 25 KHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMDQQEFSIAMK 84
K+ RQ D + G + A F +SGLP +L +IW L+D + G +++QEF +A++
Sbjct: 21 KYYRQVDT--GNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALR 78
Query: 85 LIKLKLQGQQLPVVLPPIMKQPPMF----SPLISARFGMGSMPNLSIPQPLPPAAPITSL 140
L+ G ++ + + PP F SPL+ + +P P+ I
Sbjct: 79 LVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAAELPWAVKPEDKAKYDAIFDS 138
Query: 141 SSATSGTNLPPLMMPTPLVPSVSTSSLPNGTASLIQPLPIPYSSSTLPHGSSYSLMMGGF 200
S +G + + P + S LP + L + S + H G
Sbjct: 139 LSPVNG-----FLSGDKVKPVLLNSKLP------VDILGRVWELSDIDHD-------GML 180
Query: 201 GGASIQKAQSLIDLGSSSSTSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSMS 260
A L+ + P + W V + KY + F DK M
Sbjct: 181 DRDEFAVAMFLVYCALEKEPVPMSLPPALVPPSKRKTWVVSPAEKAKYDEIFLKTDKDMD 240
Query: 261 GYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMHLTD--MAKAGQPL 318
G++SG + R L++ L T LA IW+L D G+L ++F LA HL + K P
Sbjct: 241 GFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDP- 299
Query: 319 PLTLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMEL 378
P L PE++PPS R Q +I G+ P + + K+L + E+ N+E
Sbjct: 300 PHVLTPEMIPPSDRASLQ-KNIIGSSP----VADFSAIKELDTLNNEIVDLQREKNNVEQ 354
Query: 379 EKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREE 438
+ + + +Q+ + Q E + ++LQ Q+ + Q L++ E++ +LE Q +E
Sbjct: 355 DLKEKEDTIKQRTSEVQDLQDEVQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQLKE 414
Query: 439 ERRKDIERRE---AAKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLEL 495
R+K E + + K EL Q +I E + + +EE+ RL + L +
Sbjct: 415 VRKKCAEEAQLISSLKAELTSQE----SQISTYE--EELAKAREELSRLQQETAELEESV 468
Query: 496 EALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQ 541
E SG+ Q L++ Q ++ E+ Q +++ME+K L+
Sbjct: 469 E---------SGKAQLEPLQQHLQDSQQEISSMQ--MKLMEMKDLE 503
Score = 93.6 bits (231), Expect = 1e-18
Identities = 112/481 (23%), Positives = 189/481 (39%), Gaps = 92/481 (19%)
Query: 220 TSSTASLSGNSPKTGTSEWAVPQPTRLKYRQKFNTLDKSMSGYLSGFQARNALLQSNLSQ 279
TSS +SG S WAV + KY F++L ++G+LSG + + LL S L
Sbjct: 106 TSSPLLISGTS--AAELPWAVKPEDKAKYDAIFDSLSP-VNGFLSGDKVKPVLLNSKLPV 162
Query: 280 TQLATIWTLADVDGDGQLKAEEFILAMHLTDMAKAGQPLPLTLPPELVPPSFRGGKQIDS 339
L +W L+D+D DG L +EF +AM L A +P+P++LPP LVP
Sbjct: 163 DILGRVWELSDIDHDGMLDRDEFAVAMFLVYCALEKEPVPMSLPPALVP----------- 211
Query: 340 INGTLPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQ-REAERKAQ 398
P K+ KA Y+ ++ +K + + RE K
Sbjct: 212 ---------------PSKRKTWVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTG 256
Query: 399 KEK----EEWERKQRELQEQEWKKQLELEKRLEKQRELE-----RQREEERRKDIERREA 449
W + + K Q L L Q+ ++ E +R
Sbjct: 257 LPSTLLAHIWSLCDTKDCGKLSKDQFALAFHLISQKLIKGIDPPHVLTPEMIPPSDRASL 316
Query: 450 AKQELERQRRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRL 509
K + ++ I+ + LN EIV L +K N+ +L+ +Q + +
Sbjct: 317 QKNIIGSSPVADFSAIKELDTLNN------EIVDLQREKNNVEQDLKEKEDTIKQRTSEV 370
Query: 510 QDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQ 569
QD++ + Q + T L+ +LQ + Q+ Q L L +K L E++K ++
Sbjct: 371 QDLQDEVQRENTNLQ--------------KLQAQKQQVQELLDELDEQKAQLEEQLKEVR 416
Query: 570 FSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSV 629
KK E+ +L LK +L + E + ++ E+ +
Sbjct: 417 -------------KKCAEEAQLISSLKAELTSQESQISTYEEELAKAREE---------- 453
Query: 630 LQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLE 689
L+ L EL E+ + + LE L + +D +EI +++LM+ K LE
Sbjct: 454 ----------LSRLQQETAELEESVESGKAQLEPLQQHLQDSQQEISSMQMKLMEMKDLE 503
Query: 690 D 690
+
Sbjct: 504 N 504
Score = 85.9 bits (211), Expect = 3e-16
Identities = 35/91 (38%), Positives = 59/91 (64%)
Query: 16 WAITSEERTKHDRQFDNLKPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKMD 75
WA+ E++ K+D FD+L P G+++GD+ + L S LP +L +W LSD++ DG +D
Sbjct: 122 WAVKPEDKAKYDAIFDSLSPVNGFLSGDKVKPVLLNSKLPVDILGRVWELSDIDHDGMLD 181
Query: 76 QQEFSIAMKLIKLKLQGQQLPVVLPPIMKQP 106
+ EF++AM L+ L+ + +P+ LPP + P
Sbjct: 182 RDEFAVAMFLVYCALEKEPVPMSLPPALVPP 212
Score = 64.7 bits (156), Expect = 7e-10
Identities = 35/93 (37%), Positives = 54/93 (58%), Gaps = 2/93 (2%)
Query: 16 WAITSEERTKHDRQFDNL-KPSGGYITGDQARNFFLQSGLPAPVLAEIWALSDLNKDGKM 74
W ++ E+ K+D F K G+++G + R FL++GLP+ +LA IW+L D GK+
Sbjct: 218 WVVSPAEKAKYDEIFLKTDKDMDGFVSGLEVREIFLKTGLPSTLLAHIWSLCDTKDCGKL 277
Query: 75 DQQEFSIAMKLIKLKL-QGQQLPVVLPPIMKQP 106
+ +F++A LI KL +G P VL P M P
Sbjct: 278 SKDQFALAFHLISQKLIKGIDPPHVLTPEMIPP 310
Score = 46.2 bits (108), Expect = 3e-04
Identities = 36/126 (28%), Positives = 55/126 (43%), Gaps = 12/126 (9%)
Query: 248 YRQKFNTLDKSMSGYLSGFQARNALLQSNLSQTQLATIWTLADVDGDGQLKAEEFILAMH 307
Y + + +D +G + A L +S L L IW LAD DG G L +EF +A+
Sbjct: 19 YEKYYRQVDTGNTGRVLASDAAAFLKKSGLPDLILGKIWDLADTDGKGILNKQEFFVALR 78
Query: 308 LTDMAKAGQPLPL-TLPPELVPPSFRGGKQIDSINGTLPSYQKMQEEEPQKKLPVTFEDK 366
L A+ G + L +L + PP F I+GT + +LP + +
Sbjct: 79 LVACAQNGLEVSLSSLNLAVPPPRFHDTSSPLLISGTSAA-----------ELPWAVKPE 127
Query: 367 RKANYE 372
KA Y+
Sbjct: 128 DKAKYD 133
Score = 34.3 bits (77), Expect = 1.1
Identities = 37/151 (24%), Positives = 67/151 (44%), Gaps = 22/151 (14%)
Query: 608 SKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKI 667
S + E+D+ NN++ + L NN+ LKE +T + ++ L
Sbjct: 330 SAIKELDTLNNEI-------------VDLQREKNNVEQDLKEKEDTIKQRTSEVQDLQDE 376
Query: 668 KRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQ------KRLQE 721
+ + +++ + + Q ++L DE + Q +E L KE +K EE Q L
Sbjct: 377 VQRENTNLQKLQAQKQQVQELLDELDEQKAQLEEQL-KEVRKKCAEEAQLISSLKAELTS 435
Query: 722 EKTQEKIQEEE--RKAEEKQRKDKDTLKAEE 750
+++Q EEE + EE R ++T + EE
Sbjct: 436 QESQISTYEEELAKAREELSRLQQETAELEE 466
>gi|193083145 SH3 domain containing 19 isoform c [Homo sapiens]
Length = 731
Score = 125 bits (314), Expect = 3e-28
Identities = 97/318 (30%), Positives = 152/318 (47%), Gaps = 43/318 (13%)
Query: 890 PIHGQGQVVENLK-AQALCSWTAKKDNHLNFSKHDIITVLEQQE-NWWFGEVHGGRGWFP 947
P H Q V A L + A++ + LN + +I+ +LE+ + +W+ G G FP
Sbjct: 427 PSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFP 486
Query: 948 KSYVKII----PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFT 1003
+YVK+I G KRE S+ G +A + Y + +L+F+
Sbjct: 487 ANYVKVIIDIPEGGNGKRE------------CVSSHCVKGSRCVARFEYIGEQKDELSFS 534
Query: 1004 EGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFG----------------SA 1045
EGE I++ + + EW G + R+GIFP N+V+P +D + G S
Sbjct: 535 EGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSG 594
Query: 1046 SKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKG 1105
S S ++ E + ++ A S+ LS G I IL++ S W +G LQ R +G
Sbjct: 595 SNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR-----EG 649
Query: 1106 WFPASHVKLLGPSSERATPAFHPVCQVI-AMYDYAANNEDELSFSKGQLINVMNKDDPDW 1164
FPA V+ P+ ++ A P + A+YD+ NEDELSF G +I + D DW
Sbjct: 650 IFPAVFVRPC-PAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDW 708
Query: 1165 WQGEINGVTGLFPSNYVK 1182
GE+ G +G+FP NY++
Sbjct: 709 MSGELMGKSGIFPKNYIQ 726
Score = 92.8 bits (229), Expect = 3e-18
Identities = 96/399 (24%), Positives = 165/399 (41%), Gaps = 70/399 (17%)
Query: 816 MPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQK 875
+P+ + V P++ PP LSAT S++ L N+ +S D Q SNL S K
Sbjct: 297 IPTQQPPTKVPPER---PPPPKLSATRRSNKKLPFNRSSSDMDLQKKQ-SNLATGLSKAK 352
Query: 876 KSAFTR--TVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN 933
F V P P H + + + D++ +L+Q EN
Sbjct: 353 SQVFKNQDPVLPPRPKPGH---------------------PLYSKYMRGDVLVMLKQTEN 391
Query: 934 WWFGEVHG-GRGWFPKSYVKII-PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYP 991
+ G G S +KII P E R P A + A ++V L+
Sbjct: 392 NYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAV-----VLHD 446
Query: 992 YSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFGSASKSG 1049
+ + + DL T GE + + +K D +W+ G+ ++ GIFP+NYVK D G+ +
Sbjct: 447 FPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKREC 506
Query: 1050 ASNK--KPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWF 1107
S+ K Y+ ++LS + G++I++ + W +GE++ R G F
Sbjct: 507 VSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR-----TGIF 561
Query: 1108 PASHVKLLGPSSERATPAFHPVCQVI------------------------AMYDYAANNE 1143
P + V+ P + T + + + A++ + A
Sbjct: 562 PLNFVE---PVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETS 618
Query: 1144 DELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1182
D+LSF +G I ++ + D DW +G + G+FP+ +V+
Sbjct: 619 DDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR 657
Score = 78.6 bits (192), Expect = 5e-14
Identities = 52/184 (28%), Positives = 93/184 (50%), Gaps = 22/184 (11%)
Query: 1035 KPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGE 1094
+P D SGA + A V + A + L+L G+++ +L+K + W++G
Sbjct: 423 RPNDPSHAQKPVDSGAPH-----AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGN 477
Query: 1095 LQARGKKRQKGWFPASHVKLL-----GPSSERATPAFHPV--CQVIAMYDYAANNEDELS 1147
+ Q G FPA++VK++ G + +R + H V + +A ++Y +DELS
Sbjct: 478 C-----RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELS 532
Query: 1148 FSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIE 1207
FS+G++I + + +W +GE+ G TG+FP N+V+ D S L T P++
Sbjct: 533 FSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTS-----GANVLSTKVPLK 587
Query: 1208 RKRQ 1211
K++
Sbjct: 588 TKKE 591
Score = 73.6 bits (179), Expect = 2e-12
Identities = 75/304 (24%), Positives = 124/304 (40%), Gaps = 54/304 (17%)
Query: 765 LYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE---KMPSSEN 821
L+ F A D+++ SG+I+ + EK + W G+ + G FP NYV+ +P N
Sbjct: 444 LHDFPAEQVDDLNLTSGEIVYLLEKI--DTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 501
Query: 822 EKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTR 881
K ++ + V S E + + + VN W + R
Sbjct: 502 GK----RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR 557
Query: 882 T-VSP-GSVSPIH-----------------------GQGQVVENLKA---QALCSWTAKK 913
T + P V P+ G V +L A +AL S+TA+
Sbjct: 558 TGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAET 617
Query: 914 DNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVN 972
+ L+F + D I +LE+ +W G + G FP +V+ P E +++ A V
Sbjct: 618 SDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA------EAKSMLAIVP 671
Query: 973 KKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPS 1031
K G + ALY + +L+F G+ I + D +W +G + +SGIFP
Sbjct: 672 K---------GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPK 722
Query: 1032 NYVK 1035
NY++
Sbjct: 723 NYIQ 726
Score = 55.8 bits (133), Expect = 3e-07
Identities = 53/212 (25%), Positives = 93/212 (43%), Gaps = 23/212 (10%)
Query: 764 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 823
A + + DE+SF+ G+II + E E W G +G G FP N+VE +
Sbjct: 519 ARFEYIGEQKDELSFSEGEIIILKEYVNEE--WARGEVRGRTGIFPLNFVEPVEDYPTSG 576
Query: 824 A-VSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLT------------VN 870
A V K L S +++ L + ++ + + +L+ ++
Sbjct: 577 ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLD 636
Query: 871 TSWQKKSAFTRT-VSPGS-VSPIHGQGQ-----VVENLKAQALCSWTAKKDNHLNFSKHD 923
+ W + R + P V P + + V + KA+AL + + ++ L+F D
Sbjct: 637 SDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGD 696
Query: 924 IITVLEQ-QENWWFGEVHGGRGWFPKSYVKII 954
IIT LE ++W GE+ G G FPK+Y++ +
Sbjct: 697 IITELESVDDDWMSGELMGKSGIFPKNYIQFL 728
Score = 53.9 bits (128), Expect = 1e-06
Identities = 32/121 (26%), Positives = 62/121 (51%), Gaps = 16/121 (13%)
Query: 1077 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSE--RATP-----AFHPV 1129
G ++++LK+ + + + + K G S +K++ P E R+ P A PV
Sbjct: 380 GDVLVMLKQTENNYLECQ-----KGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPV 434
Query: 1130 CQ----VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTT 1185
+ ++D+ A D+L+ + G+++ ++ K D DW++G G+FP+NYVK+
Sbjct: 435 DSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII 494
Query: 1186 D 1186
D
Sbjct: 495 D 495
Score = 46.6 bits (109), Expect = 2e-04
Identities = 22/52 (42%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE 814
+ALY F N DE+SF +GDII E + W+ G G G FP NY++
Sbjct: 677 KALYDFRGENEDELSFKAGDIITELESV--DDDWMSGELMGKSGIFPKNYIQ 726
Score = 40.0 bits (92), Expect = 0.019
Identities = 36/148 (24%), Positives = 64/148 (43%), Gaps = 15/148 (10%)
Query: 682 LMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRK 741
++ K+ + +E AR +G+ ++ N E E K+ + +K +
Sbjct: 539 IILKEYVNEEWARGEVRGRTGIFPLNF-VEPVEDYPTSGANVLSTKVPLKTKKEDSGSNS 597
Query: 742 DKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSF 801
++L AE + AL+ F A D++SF GD IQ+ E+ + W G
Sbjct: 598 QVNSLPAEWCE-----------ALHSFTAETSDDLSFKRGDRIQILERL--DSDWCRGRL 644
Query: 802 QGNFGWFPCNYVEKMPS-SENEKAVSPK 828
Q G FP +V P+ +++ A+ PK
Sbjct: 645 QDREGIFPAVFVRPCPAEAKSMLAIVPK 672
>gi|193083143 SH3 domain containing 19 isoform b [Homo sapiens]
Length = 767
Score = 125 bits (314), Expect = 3e-28
Identities = 97/318 (30%), Positives = 152/318 (47%), Gaps = 43/318 (13%)
Query: 890 PIHGQGQVVENLK-AQALCSWTAKKDNHLNFSKHDIITVLEQQE-NWWFGEVHGGRGWFP 947
P H Q V A L + A++ + LN + +I+ +LE+ + +W+ G G FP
Sbjct: 463 PSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFP 522
Query: 948 KSYVKII----PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFT 1003
+YVK+I G KRE S+ G +A + Y + +L+F+
Sbjct: 523 ANYVKVIIDIPEGGNGKRE------------CVSSHCVKGSRCVARFEYIGEQKDELSFS 570
Query: 1004 EGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFG----------------SA 1045
EGE I++ + + EW G + R+GIFP N+V+P +D + G S
Sbjct: 571 EGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSG 630
Query: 1046 SKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKG 1105
S S ++ E + ++ A S+ LS G I IL++ S W +G LQ R +G
Sbjct: 631 SNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR-----EG 685
Query: 1106 WFPASHVKLLGPSSERATPAFHPVCQVI-AMYDYAANNEDELSFSKGQLINVMNKDDPDW 1164
FPA V+ P+ ++ A P + A+YD+ NEDELSF G +I + D DW
Sbjct: 686 IFPAVFVRPC-PAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDW 744
Query: 1165 WQGEINGVTGLFPSNYVK 1182
GE+ G +G+FP NY++
Sbjct: 745 MSGELMGKSGIFPKNYIQ 762
Score = 92.8 bits (229), Expect = 3e-18
Identities = 96/399 (24%), Positives = 165/399 (41%), Gaps = 70/399 (17%)
Query: 816 MPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQK 875
+P+ + V P++ PP LSAT S++ L N+ +S D Q SNL S K
Sbjct: 333 IPTQQPPTKVPPER---PPPPKLSATRRSNKKLPFNRSSSDMDLQKKQ-SNLATGLSKAK 388
Query: 876 KSAFTR--TVSPGSVSPIHGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN 933
F V P P H + + + D++ +L+Q EN
Sbjct: 389 SQVFKNQDPVLPPRPKPGH---------------------PLYSKYMRGDVLVMLKQTEN 427
Query: 934 WWFGEVHG-GRGWFPKSYVKII-PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYP 991
+ G G S +KII P E R P A + A ++V L+
Sbjct: 428 NYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAV-----VLHD 482
Query: 992 YSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFGSASKSG 1049
+ + + DL T GE + + +K D +W+ G+ ++ GIFP+NYVK D G+ +
Sbjct: 483 FPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGNGKREC 542
Query: 1050 ASNK--KPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKGWF 1107
S+ K Y+ ++LS + G++I++ + W +GE++ R G F
Sbjct: 543 VSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR-----TGIF 597
Query: 1108 PASHVKLLGPSSERATPAFHPVCQVI------------------------AMYDYAANNE 1143
P + V+ P + T + + + A++ + A
Sbjct: 598 PLNFVE---PVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETS 654
Query: 1144 DELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1182
D+LSF +G I ++ + D DW +G + G+FP+ +V+
Sbjct: 655 DDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR 693
Score = 78.6 bits (192), Expect = 5e-14
Identities = 52/184 (28%), Positives = 93/184 (50%), Gaps = 22/184 (11%)
Query: 1035 KPKDQESFGSASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGE 1094
+P D SGA + A V + A + L+L G+++ +L+K + W++G
Sbjct: 459 RPNDPSHAQKPVDSGAPH-----AVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGN 513
Query: 1095 LQARGKKRQKGWFPASHVKLL-----GPSSERATPAFHPV--CQVIAMYDYAANNEDELS 1147
+ Q G FPA++VK++ G + +R + H V + +A ++Y +DELS
Sbjct: 514 C-----RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCVKGSRCVARFEYIGEQKDELS 568
Query: 1148 FSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSDPSQQWCADLQTLDTMQPIE 1207
FS+G++I + + +W +GE+ G TG+FP N+V+ D S L T P++
Sbjct: 569 FSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTS-----GANVLSTKVPLK 623
Query: 1208 RKRQ 1211
K++
Sbjct: 624 TKKE 627
Score = 73.6 bits (179), Expect = 2e-12
Identities = 75/304 (24%), Positives = 124/304 (40%), Gaps = 54/304 (17%)
Query: 765 LYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE---KMPSSEN 821
L+ F A D+++ SG+I+ + EK + W G+ + G FP NYV+ +P N
Sbjct: 480 LHDFPAEQVDDLNLTSGEIVYLLEKI--DTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 537
Query: 822 EKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTR 881
K ++ + V S E + + + VN W + R
Sbjct: 538 GK----RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR 593
Query: 882 T-VSP-GSVSPIH-----------------------GQGQVVENLKA---QALCSWTAKK 913
T + P V P+ G V +L A +AL S+TA+
Sbjct: 594 TGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAET 653
Query: 914 DNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVN 972
+ L+F + D I +LE+ +W G + G FP +V+ P E +++ A V
Sbjct: 654 SDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA------EAKSMLAIVP 707
Query: 973 KKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPS 1031
K G + ALY + +L+F G+ I + D +W +G + +SGIFP
Sbjct: 708 K---------GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPK 758
Query: 1032 NYVK 1035
NY++
Sbjct: 759 NYIQ 762
Score = 55.8 bits (133), Expect = 3e-07
Identities = 53/212 (25%), Positives = 93/212 (43%), Gaps = 23/212 (10%)
Query: 764 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 823
A + + DE+SF+ G+II + E E W G +G G FP N+VE +
Sbjct: 555 ARFEYIGEQKDELSFSEGEIIILKEYVNEE--WARGEVRGRTGIFPLNFVEPVEDYPTSG 612
Query: 824 A-VSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLT------------VN 870
A V K L S +++ L + ++ + + +L+ ++
Sbjct: 613 ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLD 672
Query: 871 TSWQKKSAFTRT-VSPGS-VSPIHGQGQ-----VVENLKAQALCSWTAKKDNHLNFSKHD 923
+ W + R + P V P + + V + KA+AL + + ++ L+F D
Sbjct: 673 SDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGD 732
Query: 924 IITVLEQ-QENWWFGEVHGGRGWFPKSYVKII 954
IIT LE ++W GE+ G G FPK+Y++ +
Sbjct: 733 IITELESVDDDWMSGELMGKSGIFPKNYIQFL 764
Score = 53.9 bits (128), Expect = 1e-06
Identities = 32/121 (26%), Positives = 62/121 (51%), Gaps = 16/121 (13%)
Query: 1077 GQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLLGPSSE--RATP-----AFHPV 1129
G ++++LK+ + + + + K G S +K++ P E R+ P A PV
Sbjct: 416 GDVLVMLKQTENNYLECQ-----KGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPV 470
Query: 1130 CQ----VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTT 1185
+ ++D+ A D+L+ + G+++ ++ K D DW++G G+FP+NYVK+
Sbjct: 471 DSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVII 530
Query: 1186 D 1186
D
Sbjct: 531 D 531
Score = 46.6 bits (109), Expect = 2e-04
Identities = 22/52 (42%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE 814
+ALY F N DE+SF +GDII E + W+ G G G FP NY++
Sbjct: 713 KALYDFRGENEDELSFKAGDIITELESV--DDDWMSGELMGKSGIFPKNYIQ 762
Score = 40.0 bits (92), Expect = 0.019
Identities = 36/148 (24%), Positives = 64/148 (43%), Gaps = 15/148 (10%)
Query: 682 LMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRK 741
++ K+ + +E AR +G+ ++ N E E K+ + +K +
Sbjct: 575 IILKEYVNEEWARGEVRGRTGIFPLNF-VEPVEDYPTSGANVLSTKVPLKTKKEDSGSNS 633
Query: 742 DKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSF 801
++L AE + AL+ F A D++SF GD IQ+ E+ + W G
Sbjct: 634 QVNSLPAEWCE-----------ALHSFTAETSDDLSFKRGDRIQILERL--DSDWCRGRL 680
Query: 802 QGNFGWFPCNYVEKMPS-SENEKAVSPK 828
Q G FP +V P+ +++ A+ PK
Sbjct: 681 QDREGIFPAVFVRPCPAEAKSMLAIVPK 708
>gi|193083141 SH3 domain containing 19 isoform a [Homo sapiens]
Length = 790
Score = 125 bits (314), Expect = 3e-28
Identities = 97/318 (30%), Positives = 152/318 (47%), Gaps = 43/318 (13%)
Query: 890 PIHGQGQVVENLK-AQALCSWTAKKDNHLNFSKHDIITVLEQQE-NWWFGEVHGGRGWFP 947
P H Q V A L + A++ + LN + +I+ +LE+ + +W+ G G FP
Sbjct: 486 PSHAQKPVDSGAPHAVVLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFP 545
Query: 948 KSYVKII----PGSEVKREEPEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFT 1003
+YVK+I G KRE S+ G +A + Y + +L+F+
Sbjct: 546 ANYVKVIIDIPEGGNGKRE------------CVSSHCVKGSRCVARFEYIGEQKDELSFS 593
Query: 1004 EGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFG----------------SA 1045
EGE I++ + + EW G + R+GIFP N+V+P +D + G S
Sbjct: 594 EGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSG 653
Query: 1046 SKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQKG 1105
S S ++ E + ++ A S+ LS G I IL++ S W +G LQ R +G
Sbjct: 654 SNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLDSDWCRGRLQDR-----EG 708
Query: 1106 WFPASHVKLLGPSSERATPAFHPVCQVI-AMYDYAANNEDELSFSKGQLINVMNKDDPDW 1164
FPA V+ P+ ++ A P + A+YD+ NEDELSF G +I + D DW
Sbjct: 709 IFPAVFVRPC-PAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGDIITELESVDDDW 767
Query: 1165 WQGEINGVTGLFPSNYVK 1182
GE+ G +G+FP NY++
Sbjct: 768 MSGELMGKSGIFPKNYIQ 785
Score = 95.5 bits (236), Expect = 4e-19
Identities = 99/404 (24%), Positives = 171/404 (42%), Gaps = 57/404 (14%)
Query: 816 MPSSENEKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQK 875
+P+ + V P++ PP LSAT S++ L N+ +S D Q SNL S K
Sbjct: 333 IPTQQPPTKVPPER---PPPPKLSATRRSNKKLPFNRSSSDMDLQKKQ-SNLATGLSKAK 388
Query: 876 KSAFTR--TVSPGSVSPIHG-----QGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVL 928
F V P P H V + + + S + L+ + D++ +L
Sbjct: 389 SQVFKNQDPVLPPRPKPGHPLYSKYMLSVPHGIANEDIVS---QNPGELSCKRGDVLVML 445
Query: 929 EQQENWWFGEVHG-GRGWFPKSYVKII-PGSEVKREEPEALYAAVNKKPTSAAYSVGEEY 986
+Q EN + G G S +KII P E R P A + A ++V
Sbjct: 446 KQTENNYLECQKGEDTGRVHLSQMKIITPLDEHLRSRPNDPSHAQKPVDSGAPHAV---- 501
Query: 987 IALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPSNYVKP-KDQESFGS 1044
L+ + + + DL T GE + + +K D +W+ G+ ++ GIFP+NYVK D G+
Sbjct: 502 -VLHDFPAEQVDDLNLTSGEIVYLLEKIDTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 560
Query: 1045 ASKSGASNK--KPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKR 1102
+ S+ K Y+ ++LS + G++I++ + W +GE++ R
Sbjct: 561 GKRECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR---- 616
Query: 1103 QKGWFPASHVKLLGPSSERATPAFHPVCQVI------------------------AMYDY 1138
G FP + V+ P + T + + + A++ +
Sbjct: 617 -TGIFPLNFVE---PVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSF 672
Query: 1139 AANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVK 1182
A D+LSF +G I ++ + D DW +G + G+FP+ +V+
Sbjct: 673 TAETSDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVR 716
Score = 80.5 bits (197), Expect = 1e-14
Identities = 66/264 (25%), Positives = 124/264 (46%), Gaps = 32/264 (12%)
Query: 964 PEALYAAVNKKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEE-ILVTQKDGEWWTGSI 1022
P+ + +K S + + E I S PG+L+ G+ +++ Q + +
Sbjct: 403 PKPGHPLYSKYMLSVPHGIANEDIV-----SQNPGELSCKRGDVLVMLKQTENNYLECQK 457
Query: 1023 GDRSG---IFPSNYVKPKDQESFGSASKSGASNKKPEIAQVTSAYV-----ASGSEQLSL 1074
G+ +G + + P D E S + +KP + A V A + L+L
Sbjct: 458 GEDTGRVHLSQMKIITPLD-EHLRSRPNDPSHAQKPVDSGAPHAVVLHDFPAEQVDDLNL 516
Query: 1075 APGQLILILKKNTSGWWQGELQARGKKRQKGWFPASHVKLL-----GPSSERATPAFHPV 1129
G+++ +L+K + W++G + Q G FPA++VK++ G + +R + H V
Sbjct: 517 TSGEIVYLLEKIDTDWYRGNC-----RNQIGIFPANYVKVIIDIPEGGNGKRECVSSHCV 571
Query: 1130 --CQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDS 1187
+ +A ++Y +DELSFS+G++I + + +W +GE+ G TG+FP N+V+ D
Sbjct: 572 KGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGRTGIFPLNFVEPVEDY 631
Query: 1188 DPSQQWCADLQTLDTMQPIERKRQ 1211
S L T P++ K++
Sbjct: 632 PTS-----GANVLSTKVPLKTKKE 650
Score = 73.6 bits (179), Expect = 2e-12
Identities = 75/304 (24%), Positives = 124/304 (40%), Gaps = 54/304 (17%)
Query: 765 LYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE---KMPSSEN 821
L+ F A D+++ SG+I+ + EK + W G+ + G FP NYV+ +P N
Sbjct: 503 LHDFPAEQVDDLNLTSGEIVYLLEKI--DTDWYRGNCRNQIGIFPANYVKVIIDIPEGGN 560
Query: 822 EKAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTR 881
K ++ + V S E + + + VN W + R
Sbjct: 561 GK----RECVSSHCVKGSRCVARFEYIGEQKDELSFSEGEIIILKEYVNEEWARGEVRGR 616
Query: 882 T-VSP-GSVSPIH-----------------------GQGQVVENLKA---QALCSWTAKK 913
T + P V P+ G V +L A +AL S+TA+
Sbjct: 617 TGIFPLNFVEPVEDYPTSGANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAET 676
Query: 914 DNHLNFSKHDIITVLEQ-QENWWFGEVHGGRGWFPKSYVKIIPGSEVKREEPEALYAAVN 972
+ L+F + D I +LE+ +W G + G FP +V+ P E +++ A V
Sbjct: 677 SDDLSFKRGDRIQILERLDSDWCRGRLQDREGIFPAVFVRPCPA------EAKSMLAIVP 730
Query: 973 KKPTSAAYSVGEEYIALYPYSSVEPGDLTFTEGEEILVTQK-DGEWWTGSIGDRSGIFPS 1031
K G + ALY + +L+F G+ I + D +W +G + +SGIFP
Sbjct: 731 K---------GRKAKALYDFRGENEDELSFKAGDIITELESVDDDWMSGELMGKSGIFPK 781
Query: 1032 NYVK 1035
NY++
Sbjct: 782 NYIQ 785
Score = 55.8 bits (133), Expect = 3e-07
Identities = 53/212 (25%), Positives = 93/212 (43%), Gaps = 23/212 (10%)
Query: 764 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENEK 823
A + + DE+SF+ G+II + E E W G +G G FP N+VE +
Sbjct: 578 ARFEYIGEQKDELSFSEGEIIILKEYVNEE--WARGEVRGRTGIFPLNFVEPVEDYPTSG 635
Query: 824 A-VSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLT------------VN 870
A V K L S +++ L + ++ + + +L+ ++
Sbjct: 636 ANVLSTKVPLKTKKEDSGSNSQVNSLPAEWCEALHSFTAETSDDLSFKRGDRIQILERLD 695
Query: 871 TSWQKKSAFTRT-VSPGS-VSPIHGQGQ-----VVENLKAQALCSWTAKKDNHLNFSKHD 923
+ W + R + P V P + + V + KA+AL + + ++ L+F D
Sbjct: 696 SDWCRGRLQDREGIFPAVFVRPCPAEAKSMLAIVPKGRKAKALYDFRGENEDELSFKAGD 755
Query: 924 IITVLEQ-QENWWFGEVHGGRGWFPKSYVKII 954
IIT LE ++W GE+ G G FPK+Y++ +
Sbjct: 756 IITELESVDDDWMSGELMGKSGIFPKNYIQFL 787
Score = 46.6 bits (109), Expect = 2e-04
Identities = 22/52 (42%), Positives = 29/52 (55%), Gaps = 2/52 (3%)
Query: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVE 814
+ALY F N DE+SF +GDII E + W+ G G G FP NY++
Sbjct: 736 KALYDFRGENEDELSFKAGDIITELESV--DDDWMSGELMGKSGIFPKNYIQ 785
Score = 40.0 bits (92), Expect = 0.019
Identities = 36/148 (24%), Positives = 64/148 (43%), Gaps = 15/148 (10%)
Query: 682 LMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRK 741
++ K+ + +E AR +G+ ++ N E E K+ + +K +
Sbjct: 598 IILKEYVNEEWARGEVRGRTGIFPLNF-VEPVEDYPTSGANVLSTKVPLKTKKEDSGSNS 656
Query: 742 DKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSF 801
++L AE + AL+ F A D++SF GD IQ+ E+ + W G
Sbjct: 657 QVNSLPAEWCE-----------ALHSFTAETSDDLSFKRGDRIQILERL--DSDWCRGRL 703
Query: 802 QGNFGWFPCNYVEKMPS-SENEKAVSPK 828
Q G FP +V P+ +++ A+ PK
Sbjct: 704 QDREGIFPAVFVRPCPAEAKSMLAIVPK 731
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 121 bits (303), Expect = 7e-27
Identities = 102/450 (22%), Positives = 221/450 (49%), Gaps = 60/450 (13%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQR-----------EAERK 396
+K+QEEEPQ++ + E+++ ER EL + RQ +QQQR E ER+
Sbjct: 258 EKLQEEEPQRQRELQEEEEQLRKLER--QELRRERQEEEQQQQRLRREQQLRRKQEEERR 315
Query: 397 AQKEKEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELER 456
Q+E+ ++++RE QE+ ++QL E+ ++++L R++EEERR+ RRE ++ E+
Sbjct: 316 EQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQ 375
Query: 457 QRRLEWERIRRQEL-------------LNQKNREQEEIVRLNSKKKNLHLELEALNGKHQ 503
Q R E + R Q+L Q+ R ++++ R ++ L E +H+
Sbjct: 376 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHE 435
Query: 504 QISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQEL-----QEYQNKLIYLVPEK 558
Q + + + K+ Q+ + L ++ + E E ++ +Q+L +E + + + L E+
Sbjct: 436 QKHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEE 495
Query: 559 QLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLK----------EQLDALEKETAS 608
+ + + Q + K+ E+E L QRL+ E+ + L K
Sbjct: 496 RREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEE 555
Query: 609 KLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQL-YKI 667
K E + +LK + + L +E R ++ E+L ++
Sbjct: 556 KRLEQERREQRLKREQEE-------------RRDQLLKREEERRQQRLKREQEERLEQRL 602
Query: 668 KRDKLKEIERKRLELMQKKKLEDEAAR-----KAKQGKENLWKENLRKEEEEKQKRLQEE 722
KR++++ +E++ + K+ E E R K+++ +E ++ R+++E +++RL+ E
Sbjct: 603 KREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKRE 662
Query: 723 KTQEKIQEEERKAEEKQRKDKDTLKAEEKK 752
+ +E++++ ++ E++R++++ + E+++
Sbjct: 663 EEEERLEQRLKREHEEERREQELAEEEQEQ 692
Score = 112 bits (281), Expect = 2e-24
Identities = 112/434 (25%), Positives = 208/434 (47%), Gaps = 49/434 (11%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQK-------- 399
Q EE Q++ E++ K R E EK Q L E++Q + +AQ+
Sbjct: 797 QLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGL 856
Query: 400 -EKEEWERKQRELQEQEWKKQLE---------------LEKRLEKQRELERQREEERRKD 443
E +E R Q + ++Q+W+ QLE L+++L K+++L ++ EEE +++
Sbjct: 857 QEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQRE 916
Query: 444 IERREAAKQELERQRRLEWERIRRQELLNQKNRE---QEEIVRLNSKKKNLHLELEALNG 500
ER + +QE ERQ R E + + +E L ++ RE ++E R K K L + E L G
Sbjct: 917 -EREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLG 975
Query: 501 KHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQL 560
+ + R + R KK ++ EL+ ++Q E E ++ Q+ ++Y+ K E+QL
Sbjct: 976 EEPE--KRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQL 1033
Query: 561 LNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQL 620
L E + + ++ +EE Q+ +EQL E+ET + + +
Sbjct: 1034 LREEREKRRLQE---------RERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEE 1084
Query: 621 KCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRL 680
+ ++ +L+ +E +QL E+ K +R +L+ R+
Sbjct: 1085 ELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEE 1144
Query: 681 ELMQKKK--LEDEAARKAKQGKENLWK--ENLRKEE-----EEKQKRLQEEKTQEKIQEE 731
E+ Q+++ L +E ++ +Q E ++ E L++EE EE++KR QE + Q + +EE
Sbjct: 1145 EVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEE 1204
Query: 732 ERKAEEKQR-KDKD 744
++ + KQR +D+D
Sbjct: 1205 LQRQKRKQRYRDED 1218
Score = 110 bits (274), Expect = 2e-23
Identities = 103/405 (25%), Positives = 202/405 (49%), Gaps = 42/405 (10%)
Query: 378 LEKRRQALMEQQQREAERK----AQKEKEEWERKQ-------RELQEQEWKKQLELEKRL 426
LE RR+ E+QQ+ ER+ ++E++EW +++ +LQE+E ++Q EL++
Sbjct: 216 LELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEE 275
Query: 427 EKQRELERQR-EEERRKDIERREAAKQELERQRRLEWERIRRQELLN--QKNREQEEIVR 483
E+ R+LERQ ER+++ ++++ ++E + +R+ E ER +QE Q+ REQ+E R
Sbjct: 276 EQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERR 335
Query: 484 LNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEVLDKQCDLEIMEIKQLQQE 543
++ E + Q+ R Q +R +++ ++ E ++ +Q ++++ QQ
Sbjct: 336 EQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQL 395
Query: 544 LQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLK----EQL 599
+E Q + + +Q L + + H++ E+E QRLK E+
Sbjct: 396 RREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERR 455
Query: 600 DALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQL 659
D L++E ++ E + QLK ++ +L L+E E QQ
Sbjct: 456 DWLKREEETERHEQERRKQQLKRDQEEER------------RERWLKLEE--EERREQQE 501
Query: 660 ALEQLYKIKRDKLKEIERKRLE----LMQKKKLEDEAARKAKQGKENLWK--ENLRKEEE 713
EQ + ++++ +E KR E L Q+ + E + R+ ++ +E L K E R E+E
Sbjct: 502 RREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQE 561
Query: 714 EKQKRLQEEKTQEKIQ----EEERKAEEKQRKDKDTLKAEEKKRE 754
+++RL+ E+ + + Q EEER+ + +R+ ++ L+ K+ E
Sbjct: 562 RREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREE 606
Score = 108 bits (270), Expect = 4e-23
Identities = 109/435 (25%), Positives = 218/435 (50%), Gaps = 34/435 (7%)
Query: 346 SYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQRE--AERKAQKEK-- 401
++++ QEEE ++ ++ + K+ ERG L R L EQ++R+ AE + Q+E+
Sbjct: 754 AHRQQQEEEQRRDFTWQWQAEEKS--ERGRQRL-SARPPLREQRERQLRAEERQQREQRF 810
Query: 402 --EEWERKQRELQEQEWKKQ---LELEKRLEKQRELERQREEE--RRKDIERREAAKQEL 454
EE E++QR Q +E +K+ LE E++L+++ ++ +EEE ++D ERR + +Q
Sbjct: 811 LPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRR 870
Query: 455 ERQRR--LEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDV 512
+++ R LE ER RR+ L K QE+ L +++ L E E L + ++ R +
Sbjct: 871 DQKWRWQLEEERKRRRHTLYAKPALQEQ---LRKEQQLLQEEEEELQREEREKRRRQEQE 927
Query: 513 RLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSN 572
R ++ ++ + E ++Q E E ++ Q+ ++Y+ E+QLL E
Sbjct: 928 RQYREEEQLQQE--EEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEE-------- 977
Query: 573 TPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQC 632
P+ +K +EE Q+ +EQL E+E + + + + ++ +L+
Sbjct: 978 -PEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLRE 1036
Query: 633 LLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKK--LED 690
+E +QL E+ +R +L+ RK EL Q+++ L +
Sbjct: 1037 EREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLRE 1096
Query: 691 EAARKAKQGKENLWK--ENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKA 748
E ++ +Q +E + E L++EEE+ + +E++ +++++ + R+ EE Q++++ L+
Sbjct: 1097 EPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLRE 1156
Query: 749 EEKKRETASVLVNYR 763
E +KR + YR
Sbjct: 1157 EPEKRRRQELERQYR 1171
Score = 100 bits (249), Expect = 1e-20
Identities = 103/443 (23%), Positives = 218/443 (49%), Gaps = 48/443 (10%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERK 407
Q+++ EE ++ + E++R+ +R E E+RRQ L++ +++E R+ Q +E+ ER+
Sbjct: 600 QRLKREEVER---LEQEERREQRLKREEPE-EERRQQLLKSEEQEERRQQQLRREQQERR 655
Query: 408 QRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIER-REAAKQELER-QRRLEWERI 465
++ L+ +E ++ LE+RL+++ E ER+ +E ++ E+ RE K + + Q +LE E
Sbjct: 656 EQRLKREE--EEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEAD 713
Query: 466 RRQELLNQK-------NREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQT 518
RQ + + R QE+ + ++ L + E + QQ + +D + Q
Sbjct: 714 ARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQA 773
Query: 519 -QKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPE-------KQLLNERIKNMQF 570
+K+E + E ++ Q +E Q + +PE ++ ER K +QF
Sbjct: 774 EEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQF 833
Query: 571 SNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVL 630
L ++ L++ E Q+L+E+ D L+++ + S+ + + + ++
Sbjct: 834 ---------LEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKR 884
Query: 631 QCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKR-------LELM 683
+ L L ++LR+ Q E+L + +R+K + E++R L+
Sbjct: 885 R-----RHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQE 939
Query: 684 QKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERK---AEEKQR 740
+++ L +E ++ +Q +E ++++ + +++E+Q L EE + + QE E+K EE Q+
Sbjct: 940 EEQLLREEREKRRRQERERQYRKDKKLQQKEEQ-LLGEEPEKRRRQEREKKYREEEELQQ 998
Query: 741 KDKDTLKAEEKKRETASVLVNYR 763
+++ L+ E +KR YR
Sbjct: 999 EEEQLLREEREKRRRQEWERQYR 1021
Score = 99.4 bits (246), Expect = 3e-20
Identities = 102/436 (23%), Positives = 216/436 (49%), Gaps = 56/436 (12%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERK 407
++ +++E +++ + E+K+ ER EKRR+ +++ RE E+ Q+ +E+ R+
Sbjct: 1300 EREEQKEAKRRDRKSQEEKQLLREERE----EKRRRQETDRKFREEEQLLQEREEQPLRR 1355
Query: 408 Q---RELQEQEWKKQLELEKRLEKQRELERQ-------REEERRKDIERREAAKQELERQ 457
Q R+ +E+E + Q + K LE+++ L RQ +EE++ + ER + +Q+ +R+
Sbjct: 1356 QERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRK 1415
Query: 458 RRLEWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKH------QQISGRLQD 511
R E +++ RQE + E++++ R ++K L E + +H +Q+ ++
Sbjct: 1416 FREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREE 1475
Query: 512 VRLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNER-----IK 566
+L +Q + + ++Q + + K +QEL+ + + +L E+QL ++ ++
Sbjct: 1476 QQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQ 1535
Query: 567 NMQFSNTPDSGVSLLH---KKSLEKEELCQ-RLKEQLDALEKETASKLSEMDSFNNQLKC 622
Q + G +K E+E+L Q R ++QL E++ +L E + +
Sbjct: 1536 EEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQER 1595
Query: 623 GNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDK--LKEIERKRL 680
M+D ++LR QQL E+ K + D+ L+E E ++L
Sbjct: 1596 KFMEDE-------------------QQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQL 1636
Query: 681 ELMQ--KKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEK 738
+ +K LE+E + ++ ++ L + RK EE+Q + E+ Q + QE +RK E+
Sbjct: 1637 HRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREE 1696
Query: 739 QRKDKDTLKAEEKKRE 754
+++ L+ +E++R+
Sbjct: 1697 EQQ----LRRQERERK 1708
Score = 99.0 bits (245), Expect = 3e-20
Identities = 107/476 (22%), Positives = 230/476 (48%), Gaps = 80/476 (16%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERK 407
Q++ +EE ++ E +R+ ER E E+ +Q + + E E++ ++E+E RK
Sbjct: 903 QQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRK 962
Query: 408 QRELQEQEWKKQL---ELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWER 464
++LQ++E +QL E EKR ++RE + + EEE ++ E + ++E E++RR EWER
Sbjct: 963 DKKLQQKE--EQLLGEEPEKRRRQEREKKYREEEELQQ--EEEQLLREEREKRRRQEWER 1018
Query: 465 IRRQELLNQKNREQEEIVRLNSKKKNL------HLELEALNGKHQQISGRLQDVR----- 513
R++ ++ +E+E+++R +K+ L + E E L + +Q+ G ++ R
Sbjct: 1019 QYRKK--DELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076
Query: 514 -----------------LKKQTQKTELEVLDKQCDLEIMEIKQLQQEL------------ 544
L+++ +K + ++QC E E++Q +++L
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQERERQC-REEEELQQEEEQLLREEREKRRRQE 1135
Query: 545 --QEYQNKLIYLVPEKQLLNE-----RIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKE 597
++Y+ + E+QLL E R + ++ + + ++ L +E+ +R +
Sbjct: 1136 LERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQER 1195
Query: 598 QLDALEKETASKLSEMDSFNNQLKCGNM--------DDSVLQCLLSLLSCLNNLFLLLKE 649
+ E+E + + ++ + ++ +++V + N F L++
Sbjct: 1196 ERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLED 1255
Query: 650 LRETYNTQQLALEQLYKIKRDKLKEIERKRLE-----LMQKKKLEDEAARKAKQ--GKEN 702
+ Q L+ L ++++ +E ER+R + ++++LE E ++AK+ K
Sbjct: 1256 SQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQ 1315
Query: 703 LWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQ-----RKDKDTLKAEEKKR 753
K+ LR+E EEK++R ++T K +EEE+ +E++ R+++D EE+ R
Sbjct: 1316 EEKQLLREEREEKRRR---QETDRKFREEEQLLQEREEQPLRRQERDRKFREEELR 1368
Score = 97.1 bits (240), Expect = 1e-19
Identities = 116/474 (24%), Positives = 226/474 (47%), Gaps = 70/474 (14%)
Query: 351 QEEEPQKKLPVTFEDKRKANYERGNMEL-----EKRRQALMEQQQREAERKAQKEKEEWE 405
QEEE +++ E++R+ ER +L E+R Q L Q++ E ++ + +++
Sbjct: 480 QEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLR 539
Query: 406 RKQRELQEQEWKKQLELEKRLEKQRELER-QREEERRKD--IERREAAKQEL---ERQRR 459
R+Q E +EQ K+ E EKRLE++R +R +RE+E R+D ++R E +Q+ E++ R
Sbjct: 540 REQEERREQLLKR--EEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEER 597
Query: 460 LEWERIRRQEL--LNQKNREQEEIVRLN---SKKKNLHLELEALNGKHQQISGRLQDVRL 514
LE +R++R+E+ L Q+ R ++ + R +++ L E + QQ+ Q+ R
Sbjct: 598 LE-QRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERRE 656
Query: 515 KKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNM------ 568
++ ++ E E L+++ E E ++ +QEL E E++ ERIK+
Sbjct: 657 QRLKREEEEERLEQRLKREHEEERR-EQELAE---------EEQEQARERIKSRIPKWQW 706
Query: 569 QFSNTPDSGVSLLH---------KKSLEKEELCQRLKEQLDALEKETASKLSEMDS---- 615
Q + D+ S ++ ++ E+EE +R + +L E+E A + + +
Sbjct: 707 QLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRD 766
Query: 616 FNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEI 675
F Q + + Q L + L+E RE +QL E+ + ++ L E
Sbjct: 767 FTWQWQAEEKSERGRQRLSARPP--------LREQRE----RQLRAEERQQREQRFLPEE 814
Query: 676 ERKRLELMQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKA 735
E K Q+++ E E +E + + E+ ++LQEE+ + +E R++
Sbjct: 815 EEKEQRRRQRREREKEL---------QFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRS 865
Query: 736 EEKQRKDKDTLKAEEKKRETASVLVNYRALYPFEARNHDEMSFNSGDIIQVDEK 789
+E++R K + EE+++ L AL + R ++ + +Q +E+
Sbjct: 866 QEQRRDQKWRWQLEEERKRRRHTLYAKPALQE-QLRKEQQLLQEEEEELQREER 918
Score = 96.7 bits (239), Expect = 2e-19
Identities = 100/439 (22%), Positives = 220/439 (50%), Gaps = 37/439 (8%)
Query: 344 LPSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQK-EKE 402
L Q++ ++ Q+K E+++ ERG + R + E++Q ER+ Q+ ++
Sbjct: 1518 LEEEQQLHRQQRQRKF--LQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQ 1575
Query: 403 EWERKQRELQEQEWKKQLELEKRLEKQRELERQR-EEERRKDIERREAAKQELERQRRLE 461
E +RK R L+EQ+ ++Q + K +E +++L RQ +++ R++ +R+ ++L ++R E
Sbjct: 1576 ERDRKFR-LEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQER--E 1632
Query: 462 WERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKT 521
+++ RQE ++K E+E +R +++ L + + + +Q+ ++ +L++Q +
Sbjct: 1633 EQQLHRQER-DRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDR 1691
Query: 522 ELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLL 581
+ ++Q + E K LQ+E Q + +L E++ L + + Q
Sbjct: 1692 KFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQER------ 1745
Query: 582 HKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLN 641
++K LE+E+L +EQ +E K E + + ++ L+ S +
Sbjct: 1746 YRKILEEEQLRPEREEQ-QLRRQERDRKFREEEQLRQE-----REEQQLRSQES-----D 1794
Query: 642 NLFLLLKELRETYNTQQLALEQL---YKIKRDKLK---EIERKRLELMQKKKLEDEAA-- 693
F ++LR+ QQL +Q Y+ + ++L+ + +R R E ++ + E++ A
Sbjct: 1795 RKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQ 1854
Query: 694 RKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKD----TLKAE 749
K+++ ++ LW+E +K +E++++L+EE + + +EE+R + + K ++ E
Sbjct: 1855 EKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLE 1914
Query: 750 EKKRETASVLVNYRALYPF 768
+ ASV V LY +
Sbjct: 1915 PGTHQFASVPVRSSPLYEY 1933
Score = 95.5 bits (236), Expect = 4e-19
Identities = 95/412 (23%), Positives = 212/412 (51%), Gaps = 33/412 (8%)
Query: 364 EDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERKQRELQEQE-----WKK 418
+++++A + L+ RRQ E Q+R R Q E+E +R++++ QEQE ++
Sbjct: 96 DEEKRARCDGKESLLQDRRQE--EDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEE 153
Query: 419 QLELEKRLEKQ------RELERQREE-----ERRKDIERREAAKQELERQRRLEWERIRR 467
Q E ++RLE++ EL RQR+E ERR + E+ ++ K E + + E++RR
Sbjct: 154 QSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGH-ETEEFPDEEQLRR 212
Query: 468 QEL--LNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTELEV 525
+EL L +K RE+++ R ++ + E E + ++ R ++ +L+++ + + E+
Sbjct: 213 RELLELRRKGREEKQQQR-RERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQREL 271
Query: 526 LDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKS 585
+++ L +E ++L++E QE + + L E+QL R + + + ++
Sbjct: 272 QEEEEQLRKLERQELRRERQEEEQQQQRLRREQQL--RRKQEEERREQQEERREQQERRE 329
Query: 586 LEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFL 645
++E Q+L+ + + ++ + E + QL+ ++ Q L
Sbjct: 330 QQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRRE--Q 387
Query: 646 LLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKAKQGKENLWK 705
L+ ++ QQL EQ + ++ +E + +R + +++++ E+ +K +Q + +
Sbjct: 388 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERR---E 444
Query: 706 ENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDT----LKAEEKKR 753
+ L++E+EE++ L+ E+ E+ ++E RK + K+ ++++ LK EE++R
Sbjct: 445 QRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEER 496
Score = 94.7 bits (234), Expect = 7e-19
Identities = 97/429 (22%), Positives = 207/429 (48%), Gaps = 32/429 (7%)
Query: 351 QEEEPQKKLPVTFEDKRKANYERGNME--LEKRRQALMEQQQREAERKAQKEKEEWERKQ 408
QEE Q++L +++R+ +R E LE+R + E+++RE E +++++ ER +
Sbjct: 639 QEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIK 698
Query: 409 RELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEWERIRRQ 468
+ + +W+ + E + R K R++E +RR R+E ++ R+ L+W+ R
Sbjct: 699 SRIPKWQWQLESEADARQSKVYSRPRKQEGQRR----RQEQEEKRRRRESELQWQEEER- 753
Query: 469 ELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGR--LQDVRLKKQTQKTELEVL 526
+R+Q+E + E ++ G+ Q++S R L++ R ++Q + E +
Sbjct: 754 -----AHRQQQEEEQRRDFTWQWQAEEKSERGR-QRLSARPPLREQR-ERQLRAEERQQR 806
Query: 527 DKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSL 586
+++ E E +Q +++ +E + +L +L E+Q L R + Q D ++
Sbjct: 807 EQRFLPEEEEKEQRRRQRREREKELQFLEEEEQ-LQRRERAQQLQEEEDGLQEDQERRRS 865
Query: 587 EKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLL 646
+++ Q+ + QL+ K L + QL+ + +LQ L
Sbjct: 866 QEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR---KEQQLLQEEEEELQREEREKRR 922
Query: 647 LKELRETYNTQ---QLALEQLYKIKRDKLKEIER-------KRLELMQKKKLEDEAARKA 696
+E Y + Q EQL + +R+K + ER K+L+ +++ L +E ++
Sbjct: 923 RQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRR 982
Query: 697 KQGKENLWK--ENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKAEEKKRE 754
+Q +E ++ E L++EEE+ + +E++ +++ + + RK +E Q++++ L+ E +KR
Sbjct: 983 RQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRR 1042
Query: 755 TASVLVNYR 763
YR
Sbjct: 1043 LQERERQYR 1051
Score = 94.7 bits (234), Expect = 7e-19
Identities = 106/422 (25%), Positives = 201/422 (47%), Gaps = 54/422 (12%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEW--- 404
+K +EEE Q L D++ E+ E+ R+ L E+QQ ER + +EE
Sbjct: 1414 RKFREEEQQ--LSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQ 1471
Query: 405 ERKQRELQEQEW-KKQLELEKRLEKQRELERQREEERRKDIERRE--AAKQELERQRRL- 460
ER++++L QE +K LE E++L +Q + RE+E R R+ +Q+L RQ+R
Sbjct: 1472 EREEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQR 1531
Query: 461 ----EWERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKK 516
E +++RRQE Q+ ++++ R +++ L E E QQ+S + +D + +
Sbjct: 1532 KFLQEEQQLRRQERGQQRRQDRDRKFR---EEEQLRQERE-----EQQLSRQERDRKFRL 1583
Query: 517 QTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDS 576
+ QK + +++ + ++++ + + Q Q + ++QLL ER + Q
Sbjct: 1584 EEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQER-EEQQLHRQERD 1642
Query: 577 GVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSL 636
L + L ++E Q+L+ D +E L E + QL+ D
Sbjct: 1643 RKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEE--QQLRRQERD---------- 1690
Query: 637 LSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKKLEDEAARKA 696
++ RE QQL ++ +R L+E ++ R + +++K E+E R+
Sbjct: 1691 -----------RKFRE--EEQQLRRQER---ERKFLQEEQQLRRQELERKFREEEQLRQE 1734
Query: 697 KQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEE----KQRKDKDTLKAEEKK 752
+ ++ +E RK EE+Q R + E+ Q + QE +RK E +Q +++ L+++E
Sbjct: 1735 TEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESD 1794
Query: 753 RE 754
R+
Sbjct: 1795 RK 1796
Score = 93.6 bits (231), Expect = 1e-18
Identities = 97/425 (22%), Positives = 202/425 (47%), Gaps = 39/425 (9%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQR--EAERKAQKEKEEWE 405
Q +QE E Q+ E RK E + ++R + EQ+ R E ERK +E+++
Sbjct: 1468 QLLQEREEQQLHRQ--ERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLH 1525
Query: 406 RKQRE---LQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRLEW 462
R+QR+ LQE++ ++ E ++ + R+ + + EE+ R++ E ++ ++QE +R+ RLE
Sbjct: 1526 RQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEE 1585
Query: 463 ERIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTE 522
+++RRQE +K E E+ +R ++ L E + + +Q+ ++ +L +Q + +
Sbjct: 1586 QKVRRQE-QERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRK 1644
Query: 523 L-------------EVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQ 569
+ L D + E +QL QE +E Q L +++ R + Q
Sbjct: 1645 FLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQ-----LRRQERDRKFREEEQQ 1699
Query: 570 FSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSV 629
L ++ L ++EL ++ +E+ ++ +L + + L+ +
Sbjct: 1700 LRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPER 1759
Query: 630 LQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERK-RLELMQKKKL 688
+ L + F ++LR+ QQL + +E +RK R E +++
Sbjct: 1760 EEQQLRRQE-RDRKFREEEQLRQEREEQQL-----------RSQESDRKFREEEQLRQER 1807
Query: 689 EDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDTLKA 748
E++ R ++ + W+E + EE++Q+ QE Q + +E+ E+ +R++++ +
Sbjct: 1808 EEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQE 1867
Query: 749 EEKKR 753
EE+KR
Sbjct: 1868 EEQKR 1872
Score = 90.5 bits (223), Expect = 1e-17
Identities = 94/433 (21%), Positives = 207/433 (47%), Gaps = 73/433 (16%)
Query: 351 QEEEPQKKLPVTFEDKRKANYERGNM---ELEKRRQALMEQQQREAERKAQKEKEEWERK 407
+E+ +++L + ++ + E + E EKRR+ +E+Q RE E + Q+E+E+ R+
Sbjct: 1128 REKRRRQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYRE-EEELQQEEEQLLRE 1186
Query: 408 QRELQEQEWKKQLELEKRLEKQRELERQREEERRKDI------ERREAAK--------QE 453
++E + QE ++Q E+ L++Q+ +R R+E++R D+ E+ A + +E
Sbjct: 1187 EQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRE 1246
Query: 454 LERQRRLEWERIR-------RQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQIS 506
E+ R+LE ++R Q LL ++ E R ++++ H E + +Q
Sbjct: 1247 NEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKE 1306
Query: 507 GRLQDVRLKKQTQKTELEVLDK----QCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLN 562
+ +D + +++ Q E +K + D + E +QL QE +E L +++
Sbjct: 1307 AKRRDRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREE--QPLRRQERDRKFRE 1364
Query: 563 ERIKNMQFSNTPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKC 622
E +++ + +K LE+E+ +R + + L++E QL+C
Sbjct: 1365 EELRHQEQG-----------RKFLEEEQRLRRQERERKFLKEE------------QQLRC 1401
Query: 623 GNMDDSVLQCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLEL 682
+ + Q ++ + QQL+ ++ + R++ +++ R+ E
Sbjct: 1402 QEREQQLRQD---------------RDRKFREEEQQLSRQERDRKFREEEQQVRRQERE- 1445
Query: 683 MQKKKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKD 742
+K LE+E + ++ ++ +E L +E EE+Q QE + +E++ + +E+ RK
Sbjct: 1446 --RKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQERDRKF 1503
Query: 743 KD-TLKAEEKKRE 754
++ L+++E +R+
Sbjct: 1504 REQELRSQEPERK 1516
Score = 87.0 bits (214), Expect = 1e-16
Identities = 103/424 (24%), Positives = 199/424 (46%), Gaps = 32/424 (7%)
Query: 349 KMQEEEPQKKLPVTFEDK-RKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERK 407
K QEEE + + + E + R+ ER L++ + +EQ++RE K ++E+ +
Sbjct: 520 KRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLL 579
Query: 408 QRELQEQEWKKQLELEKRLE---KQRELERQREEERRKDIERREAAKQELERQR-RLEWE 463
+RE + ++ + + E E+RLE K+ E+ER +EERR+ +RE ++E +Q + E +
Sbjct: 580 KREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQ 639
Query: 464 RIRRQELLNQKNREQEEIVRLNSKKKNLHLELEALNGKHQQISGRLQDVRLKKQTQKTEL 523
RRQ+ Q REQ+E K++ LE Q++ ++ R +++ + E
Sbjct: 640 EERRQQ---QLRREQQERREQRLKREEEEERLE------QRLKREHEEERREQELAEEEQ 690
Query: 524 EVLDKQCDLEIMEIK-QLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLH 582
E ++ I + + QL+ E Q+K +Y P KQ +R + Q L
Sbjct: 691 EQARERIKSRIPKWQWQLESEADARQSK-VYSRPRKQ-EGQRRRQEQEEKRRRRESELQW 748
Query: 583 KKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNN 642
++ Q +++ D + A + SE + + Q
Sbjct: 749 QEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQ 808
Query: 643 LFLLLKELRETYNTQQLALEQLYKIKRDKLKEIERKRLELMQKKK--LEDEAARKAKQGK 700
FL +E +E Q+ E+ + ++ + R+R + +Q+++ L+++ R+ Q +
Sbjct: 809 RFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQ 868
Query: 701 ENLWKENLRKEEEEKQKR--------LQEE--KTQEKIQEEERKAEEKQRKDKDTLKAEE 750
K + EEE K++R LQE+ K Q+ +QEEE EE QR++++ + +E
Sbjct: 869 RRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEE---EELQREEREKRRRQE 925
Query: 751 KKRE 754
++R+
Sbjct: 926 QERQ 929
Score = 84.7 bits (208), Expect = 7e-16
Identities = 101/428 (23%), Positives = 198/428 (46%), Gaps = 38/428 (8%)
Query: 348 QKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKEKEEWERK 407
+++Q+EE Q L E +R+ ER E E+ +Q E++Q E + ++ ++E ER+
Sbjct: 1084 EELQQEEEQL-LREEPEKRRRQERERQCREEEELQQ---EEEQLLREEREKRRRQELERQ 1139
Query: 408 QRELQEQEWKKQLELEKRLEKQR--ELERQREEERRKDIERREAAKQELERQRRLEWER- 464
RE +E + +++ L + EK+R ELERQ EE E + ++E E+ RR E ER
Sbjct: 1140 YREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEK-RRQERERQ 1198
Query: 465 IRRQELLNQKNREQEEIVRLNSKKKNLHLELEA------------LNGKHQQISGRLQDV 512
R +E L ++ R+Q R ++ +L + E G+ + +L+D
Sbjct: 1199 YREEEELQRQKRKQR--YRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDS 1256
Query: 513 RLKKQTQKTELEVLDKQCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSN 572
+L+ + + +L+ L L + + +QE + +Q + + E+QL E K + +
Sbjct: 1257 QLRDRQSQQDLQHL-----LGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRD 1311
Query: 573 TPDSGVSLLHKKSLEKEELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQC 632
L ++ E+EE +R + E+E + E Q + + L+
Sbjct: 1312 RKSQEEKQLLRE--EREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRH 1369
Query: 633 LLSLLSCLNNLFLLLKELRE---TYNTQQLAL----EQLYKIKRDKLKEIERKRLELMQK 685
L L ++ RE QQL +QL + + K +E E++ +
Sbjct: 1370 QEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERD 1429
Query: 686 KKLEDEAARKAKQGKENLWKENLRKEEEEKQKRLQEEKTQEKIQEEERKAEEKQRKDKDT 745
+K +E + +Q +E + E ++ +E+ ++ +EE ++ +QE E + +Q +D+
Sbjct: 1430 RKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREE--EQLLQEREEQQLHRQERDRKF 1487
Query: 746 LKAEEKKR 753
L+ E++ R
Sbjct: 1488 LEEEQQLR 1495
Score = 84.7 bits (208), Expect = 7e-16
Identities = 112/436 (25%), Positives = 206/436 (47%), Gaps = 51/436 (11%)
Query: 345 PSYQKMQEEEPQKKLPVTFEDKRKANYERGNMELEKRRQALMEQQQREAERKAQKE---- 400
P ++ QE E Q + E+ ++ + E EKRR+ +E+Q RE E Q+E
Sbjct: 1098 PEKRRRQERERQCREE---EELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLL 1154
Query: 401 KEEWERKQRELQEQEWKKQLELEKRLEKQRELERQREEERRKDIERREAAKQELERQRRL 460
+EE E+++R+ E++++++ EL+ +++ +L R+ +E+RR++ ER+ ++EL+RQ+R
Sbjct: 1155 REEPEKRRRQELERQYREEEELQ---QEEEQLLREEQEKRRQERERQYREEEELQRQKRK 1211
Query: 461 EWERI--RRQELLNQKNREQEEIVRLNS-----KKKNLHLELEALNGKHQQISGRLQDVR 513
+ R +R +L Q E+E VR N ++ +LE + +Q LQ +
Sbjct: 1212 QRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLL 1271
Query: 514 LKKQTQKTELEVLD-KQCDLEIMEIKQLQQELQ-EYQNKLIYLVPEKQLLNERIKNMQFS 571
++Q + E E +Q D E +QL++E Q E + + EKQLL E + +
Sbjct: 1272 GEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRR 1331
Query: 572 NTPDSGVSLLHKKSLEKEELCQRLKEQ-LDALEKETASKLSEMDSFNNQLKCGNMDDSVL 630
D +K E+E+L Q +EQ L E++ + E+ K
Sbjct: 1332 QETD-------RKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRK--------- 1375
Query: 631 QCLLSLLSCLNNLFLLLKELRETYNTQQLALEQLYKIKRD-KLKEIERKRLELMQKKKLE 689
L L K L+E + EQ + RD K +E E++ + +K
Sbjct: 1376 --FLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFR 1433
Query: 690 DEAARKAKQGKENLWKEN---LRKE------EEEKQKRLQEEKTQEKIQEEERKAEEKQ- 739
+E + +Q +E + E LR+E EEE+ + +EE+ + + + + EE+Q
Sbjct: 1434 EEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQ 1493
Query: 740 --RKDKDTLKAEEKKR 753
R+++D E++ R
Sbjct: 1494 LRRQERDRKFREQELR 1509
Score = 81.6 bits (200), Expect = 6e-15
Identities = 98/418 (23%), Positives = 187/418 (44%), Gaps = 40/418 (9%)
Query: 373 RGNMELEKRRQALMEQQQREAERKAQK---------EKEEWERKQRELQEQEWKKQLELE 423
R + + L EQQ+R+ E++ ++ E+E+ ER++++ ++ +K E +
Sbjct: 1259 RDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEK 1318
Query: 424 KRLEKQRELERQREEERRKDIERREAAKQELERQ--RRLEWER-IRRQELLNQ----KNR 476
+ L ++RE E++R +E + E QE E Q RR E +R R +EL +Q K
Sbjct: 1319 QLLREERE-EKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFL 1377
Query: 477 EQEEIVRLNSKKKNLHLELEAL--NGKHQQI------SGRLQDVRLKKQTQKTELEVLDK 528
E+E+ +R +++ E + L + QQ+ R ++ +L +Q + + ++
Sbjct: 1378 EEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQ 1437
Query: 529 QCDLEIMEIKQLQQELQEYQNKLIYLVPEKQLLNERIKNMQFSNTPDSGVSLLHKKSLEK 588
Q + E K L++E Q Q + E+QLL ER + Q L ++ L +
Sbjct: 1438 QVRRQERERKFLEEEQQLRQERHRKFREEEQLLQER-EEQQLHRQERDRKFLEEEQQLRR 1496
Query: 589 EELCQRLKEQLDALEKETASKLSEMDSFNNQLKCGNMDDSVLQCLLSLLSCLNNLFLLLK 648
+E ++ +EQ ++ L E + Q + Q K
Sbjct: 1497 QERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRK 1556
Query: 649 ELRETYNTQQLALEQLYKIKRDKLKEIERK--RLELMQKKKLEDEAARKAKQGKENLWKE 706
E Q+ +QL + +RD+ +E + R + ++K +EDE + ++G++ L +E
Sbjct: 1557 FREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQE 1616
Query: 707 NLRKEEEEKQKRLQEEKTQEKIQEEERK------------AEEKQRKDKDTLKAEEKK 752
RK E++Q + E+ Q QE +RK E++ R D+D EE++
Sbjct: 1617 RDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQ 1674
>gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2
[Homo sapiens]
Length = 1562
Score = 120 bits (301), Expect = 1e-26
Identities = 92/353 (26%), Positives = 171/353 (48%), Gaps = 24/353 (6%)
Query: 1207 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTK 1266
E RQ I+EL TE ++ L+++ +F +RM + + E+A +F N ELI +
Sbjct: 772 EIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNS 831
Query: 1267 LLKALRVRKKTGGEKMPVQMIGDILAAELSH------MQAYIRFCSCQLNGAALLQQKTD 1320
+A+ KK E ++ I D++ A Q +FCS Q L++ K
Sbjct: 832 WCEAM---KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQR 888
Query: 1321 EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL 1380
+++ F+ F+++ S P+C+ + L ++ MQR+T+YPLL+ SI+++T ++H L
Sbjct: 889 KESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCR 948
Query: 1381 ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGL---AEQLIFNSLTNCLGPRKLLH 1437
A ++ E+ VNE V++ EN RLE Q + L + L + L RK++H
Sbjct: 949 ARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIH 1008
Query: 1438 SGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIF 1494
G L ++ +K +LH L D L+L + + K S+++ + + +
Sbjct: 1009 EGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSK-QTFSPVLK 1067
Query: 1495 LNEVLVKLPTDPSSDEPVFHISHIDR-----VYTLRTDNINERTAWVQKIKAA 1542
LN VL++ ++D+ F I + +Y L +++ W++ ++ A
Sbjct: 1068 LNAVLIR---SVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEA 1117
>gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1
[Homo sapiens]
Length = 1522
Score = 120 bits (301), Expect = 1e-26
Identities = 92/353 (26%), Positives = 171/353 (48%), Gaps = 24/353 (6%)
Query: 1207 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTK 1266
E RQ I+EL TE ++ L+++ +F +RM + + E+A +F N ELI +
Sbjct: 732 EIDRQEVINELFVTEASHLRTLRVLDLIFYQRMKKENLMPREELARLFPNLPELIEIHNS 791
Query: 1267 LLKALRVRKKTGGEKMPVQMIGDILAAELSH------MQAYIRFCSCQLNGAALLQQKTD 1320
+A+ KK E ++ I D++ A Q +FCS Q L++ K
Sbjct: 792 WCEAM---KKLREEGPIIKEISDLMLARFDGPAREELQQVAAQFCSYQSIALELIKTKQR 848
Query: 1321 EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL 1380
+++ F+ F+++ S P+C+ + L ++ MQR+T+YPLL+ SI+++T ++H L
Sbjct: 849 KESRFQLFMQEAESHPQCRRLQLRDLIISEMQRLTKYPLLLESIIKHTEGGTSEHEKLCR 908
Query: 1381 ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGL---AEQLIFNSLTNCLGPRKLLH 1437
A ++ E+ VNE V++ EN RLE Q + L + L + L RK++H
Sbjct: 909 ARDQCREILKYVNEAVKQTENRHRLEGYQKRLDATALERASNPLAAEFKSLDLTTRKMIH 968
Query: 1438 SGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIF 1494
G L ++ +K +LH L D L+L + + K S+++ + + +
Sbjct: 969 EGPLTWRISKDKTLDLHVLLLEDLLVLLQKQDEKLLLKCHSKTAVGSSDSK-QTFSPVLK 1027
Query: 1495 LNEVLVKLPTDPSSDEPVFHISHIDR-----VYTLRTDNINERTAWVQKIKAA 1542
LN VL++ ++D+ F I + +Y L +++ W++ ++ A
Sbjct: 1028 LNAVLIR---SVATDKRAFFIICTSKLGPPQIYELVALTSSDKNTWMELLEEA 1077
>gi|39777606 Rho guanine nucleotide exchange factor 1 isoform 1 [Homo
sapiens]
Length = 927
Score = 114 bits (286), Expect = 6e-25
Identities = 94/367 (25%), Positives = 172/367 (46%), Gaps = 15/367 (4%)
Query: 1181 VKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMA 1240
+++ + P + TL ++ + KRQ I EL+ TE ++ L+++ ++F + MA
Sbjct: 403 LELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMA 462
Query: 1241 ESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA 1300
E F E+ IF + ELI ++ L L R++ G ++ IGD+L A +
Sbjct: 463 ECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYL--IEEIGDVLLARFDGAEG 520
Query: 1301 Y------IRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRI 1354
RFCS Q L+ K +D F F+++ S PRC+ + L + MQR+
Sbjct: 521 SWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRL 580
Query: 1355 TRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQC 1414
T+YPLL++SI +NT E + ++LA E E+ VN+ VR+ E+ RL+ Q +
Sbjct: 581 TKYPLLLQSIGQNT-EEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 639
Query: 1415 EGL---AEQLIFNSLTNCLGPRKLLHSGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQF 1468
L ++ ++ + +KL+H G L ++ +K E+H L +D LLL +
Sbjct: 640 SHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDER 699
Query: 1469 AVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTDN 1528
+ + + + + + + + ++ TD + +F ++Y L
Sbjct: 700 LLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQT 759
Query: 1529 INERTAW 1535
++ER W
Sbjct: 760 VSERKNW 766
>gi|39777604 Rho guanine nucleotide exchange factor 1 isoform 3 [Homo
sapiens]
Length = 879
Score = 114 bits (286), Expect = 6e-25
Identities = 94/367 (25%), Positives = 172/367 (46%), Gaps = 15/367 (4%)
Query: 1181 VKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMA 1240
+++ + P + TL ++ + KRQ I EL+ TE ++ L+++ ++F + MA
Sbjct: 355 LELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMA 414
Query: 1241 ESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA 1300
E F E+ IF + ELI ++ L L R++ G ++ IGD+L A +
Sbjct: 415 ECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYL--IEEIGDVLLARFDGAEG 472
Query: 1301 Y------IRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRI 1354
RFCS Q L+ K +D F F+++ S PRC+ + L + MQR+
Sbjct: 473 SWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRL 532
Query: 1355 TRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQC 1414
T+YPLL++SI +NT E + ++LA E E+ VN+ VR+ E+ RL+ Q +
Sbjct: 533 TKYPLLLQSIGQNT-EEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 591
Query: 1415 EGL---AEQLIFNSLTNCLGPRKLLHSGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQF 1468
L ++ ++ + +KL+H G L ++ +K E+H L +D LLL +
Sbjct: 592 SHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDER 651
Query: 1469 AVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTDN 1528
+ + + + + + + + ++ TD + +F ++Y L
Sbjct: 652 LLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQT 711
Query: 1529 INERTAW 1535
++ER W
Sbjct: 712 VSERKNW 718
>gi|15011972 Rho guanine nucleotide exchange factor 1 isoform 2 [Homo
sapiens]
Length = 912
Score = 114 bits (286), Expect = 6e-25
Identities = 94/367 (25%), Positives = 172/367 (46%), Gaps = 15/367 (4%)
Query: 1181 VKMTTDSDPSQQWCADLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMA 1240
+++ + P + TL ++ + KRQ I EL+ TE ++ L+++ ++F + MA
Sbjct: 388 LELEPEEPPGWRELVPPDTLHSLPKSQVKRQEVISELLVTEAAHVRMLRVLHDLFFQPMA 447
Query: 1241 ESGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA 1300
E F E+ IF + ELI ++ L L R++ G ++ IGD+L A +
Sbjct: 448 ECLFFPLEELQNIFPSLDELIEVHSLFLDRLMKRRQESGYL--IEEIGDVLLARFDGAEG 505
Query: 1301 Y------IRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRI 1354
RFCS Q L+ K +D F F+++ S PRC+ + L + MQR+
Sbjct: 506 SWFQKISSRFCSRQSFALEQLKAKQRKDPRFCAFVQEAESRPRCRRLQLKDMIPTEMQRL 565
Query: 1355 TRYPLLIRSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQC 1414
T+YPLL++SI +NT E + ++LA E E+ VN+ VR+ E+ RL+ Q +
Sbjct: 566 TKYPLLLQSIGQNT-EEPTEREKVELAAECCREILHHVNQAVRDMEDLLRLKDYQRRLDL 624
Query: 1415 EGL---AEQLIFNSLTNCLGPRKLLHSGKL-YKTKSNK--ELHGFLFNDFLLLTYMVKQF 1468
L ++ ++ + +KL+H G L ++ +K E+H L +D LLL +
Sbjct: 625 SHLRQSSDPMLSEFKNLDITKKKLVHEGPLTWRVTKDKAVEVHVLLLDDLLLLLQRQDER 684
Query: 1469 AVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVKLPTDPSSDEPVFHISHIDRVYTLRTDN 1528
+ + + + + + + + ++ TD + +F ++Y L
Sbjct: 685 LLLKSHSRTLTPTPDGKTMLRPVLRLTSAMTREVATDHKAFYVLFTWDQEAQIYELVAQT 744
Query: 1529 INERTAW 1535
++ER W
Sbjct: 745 VSERKNW 751
>gi|194473700 Src homology 3 domain-containing guanine nucleotide
exchange factor [Homo sapiens]
Length = 871
Score = 112 bits (280), Expect = 3e-24
Identities = 75/272 (27%), Positives = 137/272 (50%), Gaps = 21/272 (7%)
Query: 1202 TMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELI 1261
T+ ERKRQ I E+I +E Y+ L++++ +F+ S +T+ E +F N ++
Sbjct: 432 TVSQEERKRQEAIFEVISSEHSYLLSLEILIRMFKNSKELSDTMTKTERHHLFSNITDVC 491
Query: 1262 MSNTKLLKALRVRKKTGGEKMPVQMIGDILAAEL-SHMQAYIRFCSCQLNGAALLQQKTD 1320
++ K L R + + + I DI+ S Y+++C+ ++ LQ+
Sbjct: 492 EASKKFFIELEARHQNN---IFIDDISDIVEKHTASTFDPYVKYCTNEVYQQRTLQKLLA 548
Query: 1321 EDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKL 1380
+ FKE L ++ S C+ +P+ SFL+ PMQR+TR PLL+ +I + TP+ + K
Sbjct: 549 TNPSFKEVLSRIESHEDCRNLPMISFLILPMQRVTRLPLLMDTICQKTPKDSPKYEVCKR 608
Query: 1381 ALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGK 1440
AL+ +L NEG R+ E ++ + I + ++ + L+ +S R L+ G+
Sbjct: 609 ALKEVSKLVRLCNEGARKMERTEMMYTINSQLEFKIKPFPLVSSS-------RWLVKRGE 661
Query: 1441 L----------YKTKSNKELHGFLFNDFLLLT 1462
L + S ++++ FLFND L++T
Sbjct: 662 LTAYVEDTVLFSRRTSKQQVYFFLFNDVLIIT 693
Score = 39.3 bits (90), Expect = 0.033
Identities = 19/70 (27%), Positives = 36/70 (51%), Gaps = 3/70 (4%)
Query: 1044 SASKSGASNKKPEIAQVTSAYVASGSEQLSLAPGQLILILKKNTSGWWQGELQARGKKRQ 1103
S+ K A ++ ++ A ++LSL ++LI ++ + GW++GE R + +
Sbjct: 780 SSGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGE---RLRDGE 836
Query: 1104 KGWFPASHVK 1113
+GWFP K
Sbjct: 837 RGWFPMECAK 846
Score = 32.7 bits (73), Expect = 3.1
Identities = 17/50 (34%), Positives = 28/50 (56%), Gaps = 3/50 (6%)
Query: 908 SWTAKKDNHLNFSKHDIITVLEQ-QENWWFGE--VHGGRGWFPKSYVKII 954
S+TAK+ + L+ D++ + ++ + W+ GE G RGWFP K I
Sbjct: 799 SFTAKQPDELSLQVADVVLIYQRVSDGWYEGERLRDGERGWFPMECAKEI 848
Score = 31.2 bits (69), Expect = 9.0
Identities = 21/79 (26%), Positives = 33/79 (41%), Gaps = 2/79 (2%)
Query: 1109 ASHVKLLGPSSERATPAFHPVCQVIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGE 1168
A + LG SS + + QV + + A DELS ++ + + W++GE
Sbjct: 771 ARWITALGHSSGKPPADRTSLTQVEIVRSFTAKQPDELSLQVADVVLIYQRVSDGWYEGE 830
Query: 1169 --INGVTGLFPSNYVKMTT 1185
+G G FP K T
Sbjct: 831 RLRDGERGWFPMECAKEIT 849
>gi|23308553 spermatogenesis associated 13 [Homo sapiens]
Length = 652
Score = 109 bits (272), Expect = 3e-23
Identities = 89/343 (25%), Positives = 159/343 (46%), Gaps = 28/343 (8%)
Query: 1134 AMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTD----SDP 1189
A++D+ ++ EL F G +I V+ + DWW G FP+++V++ + S+
Sbjct: 154 ALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVRLRVNQEELSEN 213
Query: 1190 SQQWCADLQTLDTMQPIERK-------RQGYIHELIQTEERYMADLQLVVEVFQKRMAE- 1241
S ++ Q + Q R R I E++ TE Y+ L+ + E + ++ +
Sbjct: 214 SSSTPSEEQDEEASQSRHRHCENKQQMRTNVIREIMDTERVYIKHLRDICEGYIRQCRKH 273
Query: 1242 SGFLTEGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAY 1301
+G T ++A IF N +++ K LK L K+ E+ + IG Y
Sbjct: 274 TGMFTVAQLATIFGNIEDIYKFQRKFLKDLE--KQYNKEEPHLSEIGSCFLQNQEGFAIY 331
Query: 1302 IRFCSCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLI 1361
+C+ GA L + ++ F + + + + FLL P+Q+I +YPL +
Sbjct: 332 SEYCNNH-PGACLELANLMKQGKYRHFFEACRLLQQMIDIAIDGFLLTPVQKICKYPLQL 390
Query: 1362 RSILENTPESHADHSSLKLALERAEELCSQVNEGVREKENSDRL-EWIQAHVQCEGLAEQ 1420
+L+ T + H D+S++K A E + + +NE R+ E+ D++ W + V EGL
Sbjct: 391 AELLKYTTQEHGDYSNIKAAYEAMKNVACLINERKRKLESIDKIARWQVSIVGWEGL--D 448
Query: 1421 LIFNSLTNCLGPRKLLHSGKLYK-TKSNKELHG--FLFNDFLL 1460
++ S +L+HSG+L K TK K FLF+ L+
Sbjct: 449 ILDRS-------SELIHSGELTKITKQGKSQQRTFFLFDHQLV 484
Score = 43.9 bits (102), Expect = 0.001
Identities = 34/121 (28%), Positives = 57/121 (47%), Gaps = 14/121 (11%)
Query: 838 LSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRTVSPG----SVSPIHG 893
+ A++ SS+ +P+++ D N S + + Q A R + PG +++ +
Sbjct: 92 MRASNVSSD--GGTEPSALVD-DNGSEEDFSYEDLCQ---ASPRYLQPGGEQLAINELIS 145
Query: 894 QGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLE-QQENWWFGEVHGGRGWFPKSYVK 952
G VV A+AL D L F D+I VLE ++WW+G WFP S+V+
Sbjct: 146 DGNVV---CAEALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVR 202
Query: 953 I 953
+
Sbjct: 203 L 203
Score = 36.2 bits (82), Expect = 0.28
Identities = 21/73 (28%), Positives = 39/73 (53%), Gaps = 2/73 (2%)
Query: 988 ALYPYSSVEPGDLTFTEGEEILVTQKDG-EWWTGSIGDRSGIFPSNYVKPK-DQESFGSA 1045
AL+ + +++ +L F G+ I V + +WW G D+ FP+++V+ + +QE
Sbjct: 154 ALWDHVTMDDQELGFKAGDVIQVLEASNKDWWWGRSEDKEAWFPASFVRLRVNQEELSEN 213
Query: 1046 SKSGASNKKPEIA 1058
S S S ++ E A
Sbjct: 214 SSSTPSEEQDEEA 226
Score = 34.7 bits (78), Expect = 0.81
Identities = 17/57 (29%), Positives = 27/57 (47%), Gaps = 2/57 (3%)
Query: 764 ALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSE 820
AL+ + E+ F +GD+IQV E W +G + WFP ++V + E
Sbjct: 154 ALWDHVTMDDQELGFKAGDVIQVLE--ASNKDWWWGRSEDKEAWFPASFVRLRVNQE 208
>gi|163792208 Rho guanine exchange factor 16 [Homo sapiens]
Length = 709
Score = 109 bits (272), Expect = 3e-23
Identities = 82/291 (28%), Positives = 137/291 (47%), Gaps = 26/291 (8%)
Query: 1196 DLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFV 1255
+L LD + ERKRQ + E++ +E Y L ++VE F + +T+ E +F
Sbjct: 271 ELGILDQLSTEERKRQEAMFEILTSEFSYQHSLSILVEEFLQSKELRATVTQMEHHHLFS 330
Query: 1256 NWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELS-HMQAYIRFCSCQLNGAAL 1314
N +++ ++ + + L R K ++ V+ I DIL H YI +CS ++
Sbjct: 331 NILDVLGASQRFFEDLEQRHKA---QVLVEDISDILEEHAEKHFHPYIAYCSNEVYQQRT 387
Query: 1315 LQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHAD 1374
LQ+ + F+E L+++ P C G+P+ SFL+ PMQR+TR PLL+ ++ T
Sbjct: 388 LQKLISSNAAFREALREIERRPACGGLPMLSFLILPMQRVTRLPLLMDTLCLKTQGHSER 447
Query: 1375 HSSLKLALERAEELCSQVNEGVREKENSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRK 1434
+ + AL+ +L Q NEG E +++ + + + SL R
Sbjct: 448 YKAASRALKAISKLVRQCNEGAHRMERMEQMYTLHTQLDFSKV------KSLPLISASRW 501
Query: 1435 LLHSGKLY---------KTKSNKELHGFLFNDFLLLT-------YMVKQFA 1469
LL G+L+ K S + FLFND L++T YMV+ +A
Sbjct: 502 LLKRGELFLVEETGLFRKIASRPTCYLFLFNDVLVVTKKKSEESYMVQDYA 552
Score = 38.5 bits (88), Expect = 0.056
Identities = 15/46 (32%), Positives = 28/46 (60%), Gaps = 2/46 (4%)
Query: 911 AKKDNHLNFSKHDIITVLEQQENWWFGE--VHGGRGWFPKSYVKII 954
AK+ + + + D++ VL+Q++ W +GE G GWFP+ + + I
Sbjct: 642 AKQADEVTLQQADVVLVLQQEDGWLYGERLRDGETGWFPEDFARFI 687
>gi|190885497 Rho guanine nucleotide exchange factor 3 isoform 2 [Homo
sapiens]
Length = 532
Score = 107 bits (267), Expect = 1e-22
Identities = 89/298 (29%), Positives = 148/298 (49%), Gaps = 33/298 (11%)
Query: 1207 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTK 1266
E KRQ I EL Q EE + DL+L + + M + +TE E+ IF LI + +
Sbjct: 126 EIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEE 185
Query: 1267 LLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFK 1326
LL LR +K G + +G IL L + +Y +CS Q+ ALL K +D +
Sbjct: 186 LLSQLRDVRKPDGS---TEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKK-QDHRVQ 241
Query: 1327 EFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAE 1386
+FL++ P + + L +FL P R+ +YPLL+R IL +TP + D L+ A+ +
Sbjct: 242 DFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQ 301
Query: 1387 ELCSQVNEGVREKE---NSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYK 1443
+ +++N E E +RL +++ EG + LI +S R L G+L K
Sbjct: 302 GIVAEINTKTGESECRYYKERLLYLE-----EGQKDSLIDSS-------RVLCCHGEL-K 348
Query: 1444 TKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVK 1501
+LH FLF + L++T V + +E+L +++Y+ PI + ++L++
Sbjct: 349 NNRGVKLHVFLFQEVLVITRAV------THNEQLC-------YQLYRQPIPVKDLLLE 393
>gi|190885495 Rho guanine nucleotide exchange factor 3 isoform 1 [Homo
sapiens]
Length = 558
Score = 107 bits (267), Expect = 1e-22
Identities = 89/298 (29%), Positives = 148/298 (49%), Gaps = 33/298 (11%)
Query: 1207 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTK 1266
E KRQ I EL Q EE + DL+L + + M + +TE E+ IF LI + +
Sbjct: 152 EIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEE 211
Query: 1267 LLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFK 1326
LL LR +K G + +G IL L + +Y +CS Q+ ALL K +D +
Sbjct: 212 LLSQLRDVRKPDGS---TEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKK-QDHRVQ 267
Query: 1327 EFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAE 1386
+FL++ P + + L +FL P R+ +YPLL+R IL +TP + D L+ A+ +
Sbjct: 268 DFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQ 327
Query: 1387 ELCSQVNEGVREKE---NSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYK 1443
+ +++N E E +RL +++ EG + LI +S R L G+L K
Sbjct: 328 GIVAEINTKTGESECRYYKERLLYLE-----EGQKDSLIDSS-------RVLCCHGEL-K 374
Query: 1444 TKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVK 1501
+LH FLF + L++T V + +E+L +++Y+ PI + ++L++
Sbjct: 375 NNRGVKLHVFLFQEVLVITRAV------THNEQLC-------YQLYRQPIPVKDLLLE 419
>gi|9506401 Rho guanine nucleotide exchange factor 3 isoform 3 [Homo
sapiens]
Length = 526
Score = 107 bits (267), Expect = 1e-22
Identities = 89/298 (29%), Positives = 148/298 (49%), Gaps = 33/298 (11%)
Query: 1207 ERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFVNWKELIMSNTK 1266
E KRQ I EL Q EE + DL+L + + M + +TE E+ IF LI + +
Sbjct: 120 EIKRQEAIFELSQGEEDLIEDLKLAKKAYHDPMLKLSIMTEQELNQIFGTLDSLIPLHEE 179
Query: 1267 LLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALLQQKTDEDTDFK 1326
LL LR +K G + +G IL L + +Y +CS Q+ ALL K +D +
Sbjct: 180 LLSQLRDVRKPDGS---TEHVGPILVGWLPCLSSYDSYCSNQVAAKALLDHKK-QDHRVQ 235
Query: 1327 EFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADHSSLKLALERAE 1386
+FL++ P + + L +FL P R+ +YPLL+R IL +TP + D L+ A+ +
Sbjct: 236 DFLQRCLESPFSRKLDLWNFLDIPRSRLVKYPLLLREILRHTPNDNPDQQHLEEAINIIQ 295
Query: 1387 ELCSQVNEGVREKE---NSDRLEWIQAHVQCEGLAEQLIFNSLTNCLGPRKLLHSGKLYK 1443
+ +++N E E +RL +++ EG + LI +S R L G+L K
Sbjct: 296 GIVAEINTKTGESECRYYKERLLYLE-----EGQKDSLIDSS-------RVLCCHGEL-K 342
Query: 1444 TKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTPIFLNEVLVK 1501
+LH FLF + L++T V + +E+L +++Y+ PI + ++L++
Sbjct: 343 NNRGVKLHVFLFQEVLVITRAV------THNEQLC-------YQLYRQPIPVKDLLLE 387
>gi|166064038 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 106 bits (264), Expect = 2e-22
Identities = 73/275 (26%), Positives = 135/275 (49%), Gaps = 13/275 (4%)
Query: 1132 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSD-PS 1190
V A +++ NEDELSFSKG +I+V ++ WW+G +NG TG FPSNYV+ S+ P
Sbjct: 11 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV 70
Query: 1191 QQWCADLQT----LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLT 1246
L++ DT + + +++TE Y +LQ V+ + + + S L+
Sbjct: 71 SPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLS 130
Query: 1247 EGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA-YIRFC 1305
++ + N +E+ L+++L K + Q +G + M+ Y+ +C
Sbjct: 131 SANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ---QRVGGCFLNLMPQMKTLYLTYC 187
Query: 1306 SCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSIL 1365
+ + +L + ++E +F E K AS P + L++ L KP R+ +YP L++ +
Sbjct: 188 ANHPSAVNVLTEHSEELGEFME--TKGASSPGI--LVLTTGLSKPFMRLDKYPTLLKELE 243
Query: 1366 ENTPESHADHSSLKLALERAEELCSQVNEGVREKE 1400
+ + H D ++ ++ + L +Q E + KE
Sbjct: 244 RHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKE 278
Score = 64.7 bits (156), Expect = 7e-10
Identities = 40/105 (38%), Positives = 51/105 (48%), Gaps = 15/105 (14%)
Query: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 822
RA + F+ N DE+SF+ GD+I V V E GW G+ G GWFP NYV ++ +S E
Sbjct: 12 RAKFNFQQTNEDELSFSKGDVIHVTR--VEEGGWWEGTLNGRTGWFPSNYVREVKAS--E 67
Query: 823 KAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNL 867
K VSPK L S P + A Y NV N+
Sbjct: 68 KPVSPKSGTL-----------KSPPKGFDTTAINKSYYNVVLQNI 101
Score = 48.1 bits (113), Expect = 7e-05
Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 1/70 (1%)
Query: 988 ALYPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSAS 1046
A + + +L+F++G+ I VT+ ++G WW G++ R+G FPSNYV+ +
Sbjct: 13 AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP 72
Query: 1047 KSGASNKKPE 1056
KSG P+
Sbjct: 73 KSGTLKSPPK 82
Score = 47.4 bits (111), Expect = 1e-04
Identities = 22/59 (37%), Positives = 35/59 (59%), Gaps = 1/59 (1%)
Query: 901 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSYVKIIPGSE 958
L +A ++ ++ L+FSK D+I V +E WW G ++G GWFP +YV+ + SE
Sbjct: 9 LVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASE 67
>gi|166064036 PAK-interacting exchange factor beta isoform d [Homo
sapiens]
Length = 753
Score = 106 bits (264), Expect = 2e-22
Identities = 73/275 (26%), Positives = 135/275 (49%), Gaps = 13/275 (4%)
Query: 1132 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSD-PS 1190
V A +++ NEDELSFSKG +I+V ++ WW+G +NG TG FPSNYV+ S+ P
Sbjct: 139 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV 198
Query: 1191 QQWCADLQT----LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLT 1246
L++ DT + + +++TE Y +LQ V+ + + + S L+
Sbjct: 199 SPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLS 258
Query: 1247 EGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA-YIRFC 1305
++ + N +E+ L+++L K + Q +G + M+ Y+ +C
Sbjct: 259 SANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ---QRVGGCFLNLMPQMKTLYLTYC 315
Query: 1306 SCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSIL 1365
+ + +L + ++E +F E K AS P + L++ L KP R+ +YP L++ +
Sbjct: 316 ANHPSAVNVLTEHSEELGEFME--TKGASSPGI--LVLTTGLSKPFMRLDKYPTLLKELE 371
Query: 1366 ENTPESHADHSSLKLALERAEELCSQVNEGVREKE 1400
+ + H D ++ ++ + L +Q E + KE
Sbjct: 372 RHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKE 406
Score = 64.7 bits (156), Expect = 7e-10
Identities = 40/105 (38%), Positives = 51/105 (48%), Gaps = 15/105 (14%)
Query: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 822
RA + F+ N DE+SF+ GD+I V V E GW G+ G GWFP NYV ++ +S E
Sbjct: 140 RAKFNFQQTNEDELSFSKGDVIHVTR--VEEGGWWEGTLNGRTGWFPSNYVREVKAS--E 195
Query: 823 KAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNL 867
K VSPK L S P + A Y NV N+
Sbjct: 196 KPVSPKSGTL-----------KSPPKGFDTTAINKSYYNVVLQNI 229
Score = 50.1 bits (118), Expect = 2e-05
Identities = 46/188 (24%), Positives = 82/188 (43%), Gaps = 20/188 (10%)
Query: 783 IIQVDEKTVGEP-GWLYGSFQGNFGWFPCNYVEKMPSSENEKAVSPK--------KALLP 833
+++ +KT+ +P G+L S + G C +E++ EK +L
Sbjct: 16 VLESPKKTISDPEGFLQASLKD--GVVLCRLLERLLPGTIEKTFDANDLYQGQNFNKVLS 73
Query: 834 PTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNLTVNTSWQKKSAFTRT--VSPGSVSPI 891
V+L+ + S + A + ++ SF +L +S TRT + G +
Sbjct: 74 SLVTLNKVTADIGLGSDSVCARPSSHRIKSFDSLG------SQSLHTRTSKLFQGQYRSL 127
Query: 892 HGQGQVVENLKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSY 950
L +A ++ ++ L+FSK D+I V +E WW G ++G GWFP +Y
Sbjct: 128 DMTDNSNNQLVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNY 187
Query: 951 VKIIPGSE 958
V+ + SE
Sbjct: 188 VREVKASE 195
Score = 48.1 bits (113), Expect = 7e-05
Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 1/70 (1%)
Query: 988 ALYPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSAS 1046
A + + +L+F++G+ I VT+ ++G WW G++ R+G FPSNYV+ +
Sbjct: 141 AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP 200
Query: 1047 KSGASNKKPE 1056
KSG P+
Sbjct: 201 KSGTLKSPPK 210
>gi|166064034 PAK-interacting exchange factor beta isoform c [Homo
sapiens]
Length = 803
Score = 106 bits (264), Expect = 2e-22
Identities = 73/275 (26%), Positives = 135/275 (49%), Gaps = 13/275 (4%)
Query: 1132 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSD-PS 1190
V A +++ NEDELSFSKG +I+V ++ WW+G +NG TG FPSNYV+ S+ P
Sbjct: 189 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV 248
Query: 1191 QQWCADLQT----LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLT 1246
L++ DT + + +++TE Y +LQ V+ + + + S L+
Sbjct: 249 SPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLS 308
Query: 1247 EGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA-YIRFC 1305
++ + N +E+ L+++L K + Q +G + M+ Y+ +C
Sbjct: 309 SANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ---QRVGGCFLNLMPQMKTLYLTYC 365
Query: 1306 SCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSIL 1365
+ + +L + ++E +F E K AS P + L++ L KP R+ +YP L++ +
Sbjct: 366 ANHPSAVNVLTEHSEELGEFME--TKGASSPGI--LVLTTGLSKPFMRLDKYPTLLKELE 421
Query: 1366 ENTPESHADHSSLKLALERAEELCSQVNEGVREKE 1400
+ + H D ++ ++ + L +Q E + KE
Sbjct: 422 RHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKE 456
Score = 64.7 bits (156), Expect = 7e-10
Identities = 40/105 (38%), Positives = 51/105 (48%), Gaps = 15/105 (14%)
Query: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 822
RA + F+ N DE+SF+ GD+I V V E GW G+ G GWFP NYV ++ +S E
Sbjct: 190 RAKFNFQQTNEDELSFSKGDVIHVTR--VEEGGWWEGTLNGRTGWFPSNYVREVKAS--E 245
Query: 823 KAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNL 867
K VSPK L S P + A Y NV N+
Sbjct: 246 KPVSPKSGTL-----------KSPPKGFDTTAINKSYYNVVLQNI 279
Score = 48.1 bits (113), Expect = 7e-05
Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 1/70 (1%)
Query: 988 ALYPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSAS 1046
A + + +L+F++G+ I VT+ ++G WW G++ R+G FPSNYV+ +
Sbjct: 191 AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP 250
Query: 1047 KSGASNKKPE 1056
KSG P+
Sbjct: 251 KSGTLKSPPK 260
Score = 47.4 bits (111), Expect = 1e-04
Identities = 22/59 (37%), Positives = 35/59 (59%), Gaps = 1/59 (1%)
Query: 901 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSYVKIIPGSE 958
L +A ++ ++ L+FSK D+I V +E WW G ++G GWFP +YV+ + SE
Sbjct: 187 LVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASE 245
>gi|22027528 PAK-interacting exchange factor beta isoform b [Homo
sapiens]
Length = 782
Score = 106 bits (264), Expect = 2e-22
Identities = 73/275 (26%), Positives = 135/275 (49%), Gaps = 13/275 (4%)
Query: 1132 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSD-PS 1190
V A +++ NEDELSFSKG +I+V ++ WW+G +NG TG FPSNYV+ S+ P
Sbjct: 168 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV 227
Query: 1191 QQWCADLQT----LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLT 1246
L++ DT + + +++TE Y +LQ V+ + + + S L+
Sbjct: 228 SPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLS 287
Query: 1247 EGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA-YIRFC 1305
++ + N +E+ L+++L K + Q +G + M+ Y+ +C
Sbjct: 288 SANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ---QRVGGCFLNLMPQMKTLYLTYC 344
Query: 1306 SCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSIL 1365
+ + +L + ++E +F E K AS P + L++ L KP R+ +YP L++ +
Sbjct: 345 ANHPSAVNVLTEHSEELGEFME--TKGASSPGI--LVLTTGLSKPFMRLDKYPTLLKELE 400
Query: 1366 ENTPESHADHSSLKLALERAEELCSQVNEGVREKE 1400
+ + H D ++ ++ + L +Q E + KE
Sbjct: 401 RHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKE 435
Score = 64.7 bits (156), Expect = 7e-10
Identities = 40/105 (38%), Positives = 51/105 (48%), Gaps = 15/105 (14%)
Query: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 822
RA + F+ N DE+SF+ GD+I V V E GW G+ G GWFP NYV ++ +S E
Sbjct: 169 RAKFNFQQTNEDELSFSKGDVIHVTR--VEEGGWWEGTLNGRTGWFPSNYVREVKAS--E 224
Query: 823 KAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNL 867
K VSPK L S P + A Y NV N+
Sbjct: 225 KPVSPKSGTL-----------KSPPKGFDTTAINKSYYNVVLQNI 258
Score = 48.1 bits (113), Expect = 7e-05
Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 1/70 (1%)
Query: 988 ALYPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSAS 1046
A + + +L+F++G+ I VT+ ++G WW G++ R+G FPSNYV+ +
Sbjct: 170 AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP 229
Query: 1047 KSGASNKKPE 1056
KSG P+
Sbjct: 230 KSGTLKSPPK 239
Score = 47.4 bits (111), Expect = 1e-04
Identities = 22/59 (37%), Positives = 35/59 (59%), Gaps = 1/59 (1%)
Query: 901 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSYVKIIPGSE 958
L +A ++ ++ L+FSK D+I V +E WW G ++G GWFP +YV+ + SE
Sbjct: 166 LVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASE 224
>gi|4505573 PAK-interacting exchange factor beta isoform a [Homo
sapiens]
Length = 646
Score = 106 bits (264), Expect = 2e-22
Identities = 73/275 (26%), Positives = 135/275 (49%), Gaps = 13/275 (4%)
Query: 1132 VIAMYDYAANNEDELSFSKGQLINVMNKDDPDWWQGEINGVTGLFPSNYVKMTTDSD-PS 1190
V A +++ NEDELSFSKG +I+V ++ WW+G +NG TG FPSNYV+ S+ P
Sbjct: 11 VRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPV 70
Query: 1191 QQWCADLQT----LDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLT 1246
L++ DT + + +++TE Y +LQ V+ + + + S L+
Sbjct: 71 SPKSGTLKSPPKGFDTTAINKSYYNVVLQNILETENEYSKELQTVLSTYLRPLQTSEKLS 130
Query: 1247 EGEMALIFVNWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQA-YIRFC 1305
++ + N +E+ L+++L K + Q +G + M+ Y+ +C
Sbjct: 131 SANISYLMGNLEEICSFQQMLVQSLEECTKLPEAQ---QRVGGCFLNLMPQMKTLYLTYC 187
Query: 1306 SCQLNGAALLQQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSIL 1365
+ + +L + ++E +F E K AS P + L++ L KP R+ +YP L++ +
Sbjct: 188 ANHPSAVNVLTEHSEELGEFME--TKGASSPGI--LVLTTGLSKPFMRLDKYPTLLKELE 243
Query: 1366 ENTPESHADHSSLKLALERAEELCSQVNEGVREKE 1400
+ + H D ++ ++ + L +Q E + KE
Sbjct: 244 RHMEDYHTDRQDIQKSMAAFKNLSAQCQEVRKRKE 278
Score = 64.7 bits (156), Expect = 7e-10
Identities = 40/105 (38%), Positives = 51/105 (48%), Gaps = 15/105 (14%)
Query: 763 RALYPFEARNHDEMSFNSGDIIQVDEKTVGEPGWLYGSFQGNFGWFPCNYVEKMPSSENE 822
RA + F+ N DE+SF+ GD+I V V E GW G+ G GWFP NYV ++ +S E
Sbjct: 12 RAKFNFQQTNEDELSFSKGDVIHVTR--VEEGGWWEGTLNGRTGWFPSNYVREVKAS--E 67
Query: 823 KAVSPKKALLPPTVSLSATSTSSEPLSSNQPASVTDYQNVSFSNL 867
K VSPK L S P + A Y NV N+
Sbjct: 68 KPVSPKSGTL-----------KSPPKGFDTTAINKSYYNVVLQNI 101
Score = 48.1 bits (113), Expect = 7e-05
Identities = 23/70 (32%), Positives = 39/70 (55%), Gaps = 1/70 (1%)
Query: 988 ALYPYSSVEPGDLTFTEGEEILVTQ-KDGEWWTGSIGDRSGIFPSNYVKPKDQESFGSAS 1046
A + + +L+F++G+ I VT+ ++G WW G++ R+G FPSNYV+ +
Sbjct: 13 AKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASEKPVSP 72
Query: 1047 KSGASNKKPE 1056
KSG P+
Sbjct: 73 KSGTLKSPPK 82
Score = 47.4 bits (111), Expect = 1e-04
Identities = 22/59 (37%), Positives = 35/59 (59%), Gaps = 1/59 (1%)
Query: 901 LKAQALCSWTAKKDNHLNFSKHDIITVLEQQEN-WWFGEVHGGRGWFPKSYVKIIPGSE 958
L +A ++ ++ L+FSK D+I V +E WW G ++G GWFP +YV+ + SE
Sbjct: 9 LVVRAKFNFQQTNEDELSFSKGDVIHVTRVEEGGWWEGTLNGRTGWFPSNYVREVKASE 67
>gi|114145479 neuroepithelial cell transforming gene 1 isoform 1 [Homo
sapiens]
Length = 596
Score = 105 bits (261), Expect = 5e-22
Identities = 96/369 (26%), Positives = 170/369 (46%), Gaps = 52/369 (14%)
Query: 1196 DLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFV 1255
D+ +++ E +RQ I+E+ + E+ + DL+L + + M + ++E E+ IF
Sbjct: 161 DITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFG 220
Query: 1256 NWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALL 1315
+ I + LL + K G V+ IG IL + L + AY +CS QL ALL
Sbjct: 221 DLDSYIPLHEDLLTRIGEATKPDGT---VEQIGHILVSWLPRLNAYRGYCSNQLAAKALL 277
Query: 1316 QQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADH 1375
QK +D ++FL++ P + + L SFL P R+ +YPLL++ IL++TP+ H D
Sbjct: 278 DQKK-QDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDV 336
Query: 1376 SSLKLALERAEELCSQVNEGVREKENS---DRLEWIQAHVQCEGLAEQLIFNSLTNCLGP 1432
L+ A+ + + S +N E E D+LE++ + + +
Sbjct: 337 QLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRDPRIEASKV---------- 386
Query: 1433 RKLLHSGKLYKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTP 1492
LL G+L ++KS +L+ FLF D L+LT V + +++Y+ P
Sbjct: 387 --LLCHGEL-RSKSGHKLYIFLFQDILVLTRPV-------------TRNERHSYQVYRQP 430
Query: 1493 IFLNEVLVKLPTDP------------SSDEPV-------FHISHIDRVYTLRTDNINERT 1533
I + E++++ D S+ E FH + +TL+ +++ +
Sbjct: 431 IPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQ 490
Query: 1534 AWVQKIKAA 1542
W I+AA
Sbjct: 491 QWFNCIRAA 499
>gi|19923327 neuroepithelial cell transforming gene 1 isoform 2 [Homo
sapiens]
Length = 542
Score = 105 bits (261), Expect = 5e-22
Identities = 96/369 (26%), Positives = 170/369 (46%), Gaps = 52/369 (14%)
Query: 1196 DLQTLDTMQPIERKRQGYIHELIQTEERYMADLQLVVEVFQKRMAESGFLTEGEMALIFV 1255
D+ +++ E +RQ I+E+ + E+ + DL+L + + M + ++E E+ IF
Sbjct: 107 DITMKESLTTREIRRQEAIYEMSRGEQDLIEDLKLARKAYHDPMLKLSIMSEEELTHIFG 166
Query: 1256 NWKELIMSNTKLLKALRVRKKTGGEKMPVQMIGDILAAELSHMQAYIRFCSCQLNGAALL 1315
+ I + LL + K G V+ IG IL + L + AY +CS QL ALL
Sbjct: 167 DLDSYIPLHEDLLTRIGEATKPDGT---VEQIGHILVSWLPRLNAYRGYCSNQLAAKALL 223
Query: 1316 QQKTDEDTDFKEFLKKLASDPRCKGMPLSSFLLKPMQRITRYPLLIRSILENTPESHADH 1375
QK +D ++FL++ P + + L SFL P R+ +YPLL++ IL++TP+ H D
Sbjct: 224 DQKK-QDPRVQDFLQRCLESPFSRKLDLWSFLDIPRSRLVKYPLLLKEILKHTPKEHPDV 282
Query: 1376 SSLKLALERAEELCSQVNEGVREKENS---DRLEWIQAHVQCEGLAEQLIFNSLTNCLGP 1432
L+ A+ + + S +N E E D+LE++ + + +
Sbjct: 283 QLLEDAILIIQGVLSDINLKKGESECQYYIDKLEYLDEKQRDPRIEASKV---------- 332
Query: 1433 RKLLHSGKLYKTKSNKELHGFLFNDFLLLTYMVKQFAVSSGSEKLFSSKSNAQFKMYKTP 1492
LL G+L ++KS +L+ FLF D L+LT V + +++Y+ P
Sbjct: 333 --LLCHGEL-RSKSGHKLYIFLFQDILVLTRPV-------------TRNERHSYQVYRQP 376
Query: 1493 IFLNEVLVKLPTDP------------SSDEPV-------FHISHIDRVYTLRTDNINERT 1533
I + E++++ D S+ E FH + +TL+ +++ +
Sbjct: 377 IPVQELVLEDLQDGDVRMGGSFRGAFSNSEKAKNIFRIRFHDPSPAQSHTLQANDVFHKQ 436
Query: 1534 AWVQKIKAA 1542
W I+AA
Sbjct: 437 QWFNCIRAA 445
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.313 0.130 0.372
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 66,091,848
Number of Sequences: 37866
Number of extensions: 3314675
Number of successful extensions: 74862
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 1192
Number of HSP's successfully gapped in prelim test: 1545
Number of HSP's that attempted gapping in prelim test: 18285
Number of HSP's gapped (non-prelim): 22741
length of query: 1697
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1581
effective length of database: 13,855,062
effective search space: 21904853022
effective search space used: 21904853022
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 69 (31.2 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.