Guide to the Human Genome
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Search of human proteins with 194272148

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|194272148 epsin 1 isoform a [Homo sapiens]
         (662 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|194272148 epsin 1 isoform a [Homo sapiens]                        1363   0.0  
gi|41350201 epsin 1 isoform c [Homo sapiens]                         1131   0.0  
gi|194248095 epsin 1 isoform b [Homo sapiens]                        1123   0.0  
gi|156671217 epsin 2 isoform a [Homo sapiens]                         488   e-138
gi|157388929 epsin 3 [Homo sapiens]                                   414   e-115
gi|156671215 epsin 2 isoform b [Homo sapiens]                         410   e-114
gi|31377575 ENTH domain containing 1 [Homo sapiens]                   211   1e-54
gi|156671219 epsin 2 isoform c [Homo sapiens]                         189   7e-48
gi|7661968 epsin 4 [Homo sapiens]                                     169   6e-42
gi|163965366 nascent polypeptide-associated complex alpha subuni...    92   2e-18
gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo ...    79   1e-14
gi|110832843 TBP-associated factor 4 [Homo sapiens]                    74   3e-13
gi|72004269 tetra-peptide repeat homeobox [Homo sapiens]               72   1e-12
gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo sapi...    72   2e-12
gi|116284392 mucin 2 precursor [Homo sapiens]                          72   2e-12
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    72   2e-12
gi|146219843 Snf2-related CBP activator protein [Homo sapiens]         71   3e-12
gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo sap...    70   6e-12
gi|149773456 hypothetical protein LOC643314 [Homo sapiens]             69   1e-11
gi|122937267 lemur tyrosine kinase 3 [Homo sapiens]                    69   1e-11
gi|21389357 MAPK-interacting and spindle-stabilizing protein [Ho...    69   1e-11
gi|42544130 splicing factor 1 isoform 1 [Homo sapiens]                 69   2e-11
gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo sap...    68   3e-11
gi|149158690 HLA-B associated transcript-2 [Homo sapiens]              68   3e-11
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   67   4e-11
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   67   4e-11
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   67   4e-11
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    67   4e-11
gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]     67   4e-11
gi|42544125 splicing factor 1 isoform 2 [Homo sapiens]                 67   5e-11

>gi|194272148 epsin 1 isoform a [Homo sapiens]
          Length = 662

 Score = 1363 bits (3528), Expect = 0.0
 Identities = 662/662 (100%), Positives = 662/662 (100%)

Query: 1   MGDQSWLWNQAAPGVRSPVFACSVEKGNVPLVLSEHLAHSRDPGSGAVRFLISPEPWASA 60
           MGDQSWLWNQAAPGVRSPVFACSVEKGNVPLVLSEHLAHSRDPGSGAVRFLISPEPWASA
Sbjct: 1   MGDQSWLWNQAAPGVRSPVFACSVEKGNVPLVLSEHLAHSRDPGSGAVRFLISPEPWASA 60

Query: 61  ILGTSGLLASPVLPAALDAVTCQHLPQPSSGSRPISPRIGALCPLLLQPGTMSTSSLRRQ 120
           ILGTSGLLASPVLPAALDAVTCQHLPQPSSGSRPISPRIGALCPLLLQPGTMSTSSLRRQ
Sbjct: 61  ILGTSGLLASPVLPAALDAVTCQHLPQPSSGSRPISPRIGALCPLLLQPGTMSTSSLRRQ 120

Query: 121 MKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGK 180
           MKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGK
Sbjct: 121 MKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRLNDHGK 180

Query: 181 NWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVREKAKQ 240
           NWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVREKAKQ
Sbjct: 181 NWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVREKAKQ 240

Query: 241 LVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQSSGEEELQLQ 300
           LVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQSSGEEELQLQ
Sbjct: 241 LVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQSSGEEELQLQ 300

Query: 301 LALAMSKEEADQEERIRRGDDLRLQMAIEESKRETGGKEESSLMDLADVFTAPAPAPTTD 360
           LALAMSKEEADQEERIRRGDDLRLQMAIEESKRETGGKEESSLMDLADVFTAPAPAPTTD
Sbjct: 301 LALAMSKEEADQEERIRRGDDLRLQMAIEESKRETGGKEESSLMDLADVFTAPAPAPTTD 360

Query: 361 PWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPW 420
           PWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPW
Sbjct: 361 PWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPW 420

Query: 421 GGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAA 480
           GGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAA
Sbjct: 421 GGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAA 480

Query: 481 GGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGS 540
           GGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGS
Sbjct: 481 GGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGS 540

Query: 541 PPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGP 600
           PPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGP
Sbjct: 541 PPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGP 600

Query: 601 SVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNTNPF 660
           SVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNTNPF
Sbjct: 601 SVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNTNPF 660

Query: 661 LL 662
           LL
Sbjct: 661 LL 662


>gi|41350201 epsin 1 isoform c [Homo sapiens]
          Length = 550

 Score = 1131 bits (2926), Expect = 0.0
 Identities = 550/551 (99%), Positives = 550/551 (99%), Gaps = 1/551 (0%)

Query: 112 MSTSSLRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMI 171
           MSTSSLRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMI
Sbjct: 1   MSTSSLRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMI 60

Query: 172 WKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQG 231
           WKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQG
Sbjct: 61  WKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQG 120

Query: 232 VNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQS 291
           VNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQS
Sbjct: 121 VNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQS 180

Query: 292 SGEEELQLQLALAMSKEEADQEERIRRGDDLRLQMAIEESKRETGGKEESSLMDLADVFT 351
           SGEEELQLQLALAMSKEEADQEERIRRGDDLRLQMAIEESKRETGGKEESSLMDLADVFT
Sbjct: 181 SGEEELQLQLALAMSKEEADQEERIRRGDDLRLQMAIEESKRETGGKEESSLMDLADVFT 240

Query: 352 APAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPAA 411
           APAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPAA
Sbjct: 241 APAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPAA 300

Query: 412 PAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSDPWGGSPAK 471
           PAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSDPWGGSPAK
Sbjct: 301 PAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSDPWGGSPAK 360

Query: 472 PSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGAFDMSGVR 531
           PSTNGTT AGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGAFDMSGVR
Sbjct: 361 PSTNGTT-AGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGAFDMSGVR 419

Query: 532 GSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFL 591
           GSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFL
Sbjct: 420 GSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFL 479

Query: 592 PGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLGGGPGLPPMMPPG 651
           PGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLGGGPGLPPMMPPG
Sbjct: 480 PGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLGGGPGLPPMMPPG 539

Query: 652 PPAPNTNPFLL 662
           PPAPNTNPFLL
Sbjct: 540 PPAPNTNPFLL 550


>gi|194248095 epsin 1 isoform b [Homo sapiens]
          Length = 576

 Score = 1124 bits (2906), Expect = 0.0
 Identities = 551/576 (95%), Positives = 551/576 (95%), Gaps = 25/576 (4%)

Query: 112 MSTSSLRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMI 171
           MSTSSLRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMI
Sbjct: 1   MSTSSLRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMI 60

Query: 172 WKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQG 231
           WKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQG
Sbjct: 61  WKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQG 120

Query: 232 VNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQS 291
           VNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQS
Sbjct: 121 VNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQS 180

Query: 292 SGEEELQLQLALAMSKEEADQ-------------------------EERIRRGDDLRLQM 326
           SGEEELQLQLALAMSKEEADQ                         EERIRRGDDLRLQM
Sbjct: 181 SGEEELQLQLALAMSKEEADQPPSCGPEDDAQLQLALSLSREEHDKEERIRRGDDLRLQM 240

Query: 327 AIEESKRETGGKEESSLMDLADVFTAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPP 386
           AIEESKRETGGKEESSLMDLADVFTAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPP
Sbjct: 241 AIEESKRETGGKEESSLMDLADVFTAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPP 300

Query: 387 VPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPV 446
           VPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPV
Sbjct: 301 VPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPV 360

Query: 447 SGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSS 506
           SGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSS
Sbjct: 361 SGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSS 420

Query: 507 AGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAA 566
           AGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAA
Sbjct: 421 AGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAA 480

Query: 567 LVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPP 626
           LVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPP
Sbjct: 481 LVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPP 540

Query: 627 VPGAPPTYISPLGGGPGLPPMMPPGPPAPNTNPFLL 662
           VPGAPPTYISPLGGGPGLPPMMPPGPPAPNTNPFLL
Sbjct: 541 VPGAPPTYISPLGGGPGLPPMMPPGPPAPNTNPFLL 576


>gi|156671217 epsin 2 isoform a [Homo sapiens]
          Length = 584

 Score =  488 bits (1257), Expect = e-138
 Identities = 304/636 (47%), Positives = 366/636 (57%), Gaps = 137/636 (21%)

Query: 112 MSTSSLRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMI 171
           M+TSS+RRQMKNIV+NYSEAEIKVREATSNDPWGPSSSLM+EIADLTYNVVAFSEIMSM+
Sbjct: 1   MTTSSIRRQMKNIVNNYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVAFSEIMSMV 60

Query: 172 WKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQG 231
           WKRLNDHGKNWRHVYKA+TL++YLIKTGSERV+QQC+EN++A+QTLKDFQY+DRDGKDQG
Sbjct: 61  WKRLNDHGKNWRHVYKALTLLDYLIKTGSERVAQQCRENIFAIQTLKDFQYIDRDGKDQG 120

Query: 232 VNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSA-----AVGSGPP----- 281
           +NVREK+KQLVALL+DE+RL+ ERA ALKTKE++AQ AT   +       GS  P     
Sbjct: 121 INVREKSKQLVALLKDEERLKAERAQALKTKERMAQVATGMGSNQITFGRGSSQPNLSTS 180

Query: 282 -------------------------PEAEQAWPQSSGEEELQLQLALAMSKEEADQEERI 316
                                     E EQA PQ+SGEEELQLQLALAMS+E A+QEER+
Sbjct: 181 HSEQEYGKAGGSPASYHGSTSPRVSSELEQARPQTSGEEELQLQLALAMSREVAEQEERL 240

Query: 317 RRGDDLRLQMAIEESKRET----GGKEESSLMDLADVFTAPAPAPTTDPWGGPAPMAAAV 372
           RRGDDLRLQMA+EES+R+T      KE  SL     +       P++ P           
Sbjct: 241 RRGDDLRLQMALEESRRDTVKIPKKKEHGSLPQQTTLLDLMDALPSSGP----------- 289

Query: 373 PTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPW-----RPAAPAGPSVDPWG-GTPAP 426
             AA  ++PWG        +PWGGPA   ++ DPW     +PAA    S+DPWG  T A 
Sbjct: 290 --AAQKAEPWGPSASTNQTNPWGGPAAPASTSDPWPSFGTKPAA----SIDPWGVPTGAT 343

Query: 427 AAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFD-- 484
                   DPW +S      +G  ASD W              A  +T   + +G F+  
Sbjct: 344 VQSVPKNSDPWAASQQPASSAGKRASDAW-------------GAVSTTKPVSVSGSFELF 390

Query: 485 -----TEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVG 539
                T  D+FS+FD LRT+  T+ S           +P+++ G                
Sbjct: 391 SNLNGTIKDDFSEFDNLRTSKKTAES--------VTSLPSQNNGTTSPDPFESQPLTVAS 442

Query: 540 SPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATG 599
           S P +A        RKTPESFLGPNAALV+LDSLV+RP P    A++ NPFL  G PAT 
Sbjct: 443 SKPSSA--------RKTPESFLGPNAALVNLDSLVTRPAPP---AQSLNPFLAPGAPATS 491

Query: 600 PSVTNPFQPAPPATLTLNQLRLSPV--------------------------PPVPGAPPT 633
             V NPFQ   P  LTLNQLR SPV                           P  GA  +
Sbjct: 492 APV-NPFQVNQPQPLTLNQLRGSPVLGTSTSFGPGPGVESMAVASMTSAAPQPALGATGS 550

Query: 634 YISPLG-------GGPGLPPMMPPGPPAPNTNPFLL 662
            ++PLG       G  G+PP          TNPFLL
Sbjct: 551 SLTPLGPAMMNMVGSVGIPP--SAAQATGTTNPFLL 584


>gi|157388929 epsin 3 [Homo sapiens]
          Length = 632

 Score =  414 bits (1064), Expect = e-115
 Identities = 287/672 (42%), Positives = 354/672 (52%), Gaps = 162/672 (24%)

Query: 112 MSTSSLRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMI 171
           M+TS+LRRQ+KNIVHNYSEAEIKVREATSNDPWGP SSLMSEIADLT+N VAF+E+M M+
Sbjct: 1   MTTSALRRQVKNIVHNYSEAEIKVREATSNDPWGPPSSLMSEIADLTFNTVAFTEVMGML 60

Query: 172 WKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQG 231
           W+RLND GKNWRHVYKA+TL++YL+KTGSERV+ QC+EN+Y +QTLKDFQY+DRDGKDQG
Sbjct: 61  WRRLNDSGKNWRHVYKALTLLDYLLKTGSERVAHQCRENLYTIQTLKDFQYIDRDGKDQG 120

Query: 232 VNVREKAKQLVALLRDEDRLREERAHALKTKEKLA-----------------------QT 268
           VNVREK KQ++ALL+DE+RLR+ER HALKTKE++A                         
Sbjct: 121 VNVREKVKQVMALLKDEERLRQERTHALKTKERMALEGIGIGSGQLGFSRRYGEDYSRSR 180

Query: 269 ATASSAAVGSGPP---PEAEQAWPQSSGEEELQLQLALAMSKEEADQ--EERIRRGDDLR 323
            + SS    S  P    + EQA PQ+SGEEELQLQLALAMS+EEA++       R +DL+
Sbjct: 181 GSPSSYNSSSSSPRYTSDLEQARPQTSGEEELQLQLALAMSREEAEKPVPPASHRDEDLQ 240

Query: 324 LQMAI----------------------------------EESKRETGGKEE------SSL 343
           LQ+A+                                   E +RE   +EE      SS+
Sbjct: 241 LQLALRLSRQEHEKEVRSWQGDGSPMANGAGAVVHHQRDREPEREERKEEEKLKTSQSSI 300

Query: 344 MDLADVFTAPAPAPTT----DPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAP 399
           +DLAD+F      P+T    DPW  P       P    +   WG     P+ADPW  P P
Sbjct: 301 LDLADIFVPALAPPSTHCSADPWDIP----GFRPNTEASGSSWG-----PSADPW-SPIP 350

Query: 400 TP---ASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWT 456
           +    +   PW    P   S +PWG TP   AG  PT DPW        ++ P    P T
Sbjct: 351 SGTVLSRSQPW-DLTPMLSSSEPWGRTPVLPAGP-PTTDPWA-------LNSPHHKLPST 401

Query: 457 PAPAFSDPWGGSPAKPST-NGTTAAGGFDTEPDEFSDFDRLRTALPT-SGSSAGELELLA 514
            A    DPWG S     T  G +    F   P+     + L  ALP+   SS  EL+L  
Sbjct: 402 GA----DPWGASLETSDTPGGASTFDPFAKPPESTETKEGLEQALPSGKPSSPVELDLFG 457

Query: 515 GEVPA------RSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNA-AL 567
              P+      + P A D+    G L EA+  P   A         +TPESFLGP+A +L
Sbjct: 458 DPSPSSKQNGTKEPDALDL----GILGEALTQPSKEARAC------RTPESFLGPSASSL 507

Query: 568 VDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRL-SPVPP 626
           V+LDSLV      P  AK  NPFL G    + PS TNPF    P   TLNQ+R  SP   
Sbjct: 508 VNLDSLVK----APQVAKTRNPFLTG---LSAPSPTNPFGAGEPGRPTLNQMRTGSPALG 560

Query: 627 VPGAP--------------PTYISPLGGGPGLP---------------PMMP-------- 649
           + G P              P  +S +  G  LP               P++P        
Sbjct: 561 LAGGPVGAPLGSMTYSASLPLPLSSVPAGLTLPASVSVFPQAGAFAPQPLLPTPSSAGPR 620

Query: 650 PGPPAPNTNPFL 661
           P PP   TNPFL
Sbjct: 621 PPPPQTGTNPFL 632


>gi|156671215 epsin 2 isoform b [Homo sapiens]
          Length = 641

 Score =  410 bits (1053), Expect = e-114
 Identities = 281/681 (41%), Positives = 350/681 (51%), Gaps = 170/681 (24%)

Query: 112 MSTSSLRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMI 171
           M+TSS+RRQMKNIV+NYSEAEIKVREATSNDPWGPSSSLM+EIADLTYNVVAFSEIMSM+
Sbjct: 1   MTTSSIRRQMKNIVNNYSEAEIKVREATSNDPWGPSSSLMTEIADLTYNVVAFSEIMSMV 60

Query: 172 WKRLNDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQG 231
           WKRLNDHGKNWRHVYKA+TL++YLIKTGSERV+QQC+EN++A+QTLKDFQY+DRDGKDQG
Sbjct: 61  WKRLNDHGKNWRHVYKALTLLDYLIKTGSERVAQQCRENIFAIQTLKDFQYIDRDGKDQG 120

Query: 232 VNVREKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSA-----AVGSGPP----P 282
           +NVREK+KQLVALL+DE+RL+ ERA ALKTKE++AQ AT   +       GS  P     
Sbjct: 121 INVREKSKQLVALLKDEERLKAERAQALKTKERMAQVATGMGSNQITFGRGSSQPNLSTS 180

Query: 283 EAEQAWPQSSG-------------------------EEELQ---------LQLALAMSKE 308
            +EQ + ++ G                          EELQ           L LA S+ 
Sbjct: 181 HSEQEYGKAGGSPASYHGSPEASLCPQHRTGAPLGQSEELQPLSQRHPFLPHLGLA-SRP 239

Query: 309 EADQE------ERIRRGDDLRLQMAIEESKRETGGKEESSL------------------- 343
             D        +R  R    R+   +E+++ +T G+EE  L                   
Sbjct: 240 NGDWSQPCLTCDRAARATSPRVSSELEQARPQTSGEEELQLQLALAMSREVAEQEERLRR 299

Query: 344 -------MDLADVFTAPAPAPTTDPWGGPAPMAA------AVPTAAPT---SDPWGGPPV 387
                  M L +        P     G             A+P++ P    ++PWG    
Sbjct: 300 GDDLRLQMALEESRRDTVKIPKKKEHGSLPQQTTLLDLMDALPSSGPAAQKAEPWGPSAS 359

Query: 388 PPAADPWGGPAPTPASGDPW-----RPAAPAGPSVDPWG-GTPAPAAGEGPTPDPWGSSD 441
               +PWGGPA   ++ DPW     +PAA    S+DPWG  T A         DPW +S 
Sbjct: 360 TNQTNPWGGPAAPASTSDPWPSFGTKPAA----SIDPWGVPTGATVQSVPKNSDPWAASQ 415

Query: 442 GGVPVSGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFD-------TEPDEFSDFD 494
                +G  ASD W              A  +T   + +G F+       T  D+FS+FD
Sbjct: 416 QPASSAGKRASDAW-------------GAVSTTKPVSVSGSFELFSNLNGTIKDDFSEFD 462

Query: 495 RLRTALPTSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTR 554
            LRT+  T+ S           +P+++ G                S P +A        R
Sbjct: 463 NLRTSKKTAES--------VTSLPSQNNGTTSPDPFESQPLTVASSKPSSA--------R 506

Query: 555 KTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATL 614
           KTPESFLGPNAALV+LDSLV+RP P    A++ NPFL  G PAT   V NPFQ   P  L
Sbjct: 507 KTPESFLGPNAALVNLDSLVTRPAPP---AQSLNPFLAPGAPATSAPV-NPFQVNQPQPL 562

Query: 615 TLNQLRLSPV--------------------------PPVPGAPPTYISPLG-------GG 641
           TLNQLR SPV                           P  GA  + ++PLG       G 
Sbjct: 563 TLNQLRGSPVLGTSTSFGPGPGVESMAVASMTSAAPQPALGATGSSLTPLGPAMMNMVGS 622

Query: 642 PGLPPMMPPGPPAPNTNPFLL 662
            G+PP          TNPFLL
Sbjct: 623 VGIPP--SAAQATGTTNPFLL 641


>gi|31377575 ENTH domain containing 1 [Homo sapiens]
          Length = 607

 Score =  211 bits (538), Expect = 1e-54
 Identities = 98/163 (60%), Positives = 129/163 (79%)

Query: 116 SLRRQMKNIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKRL 175
           + RRQ+KN V NYS+AEIKVREATSNDPWGPSSSLM +I+DLT+N ++ SEIM+M+W RL
Sbjct: 2   AFRRQVKNFVKNYSDAEIKVREATSNDPWGPSSSLMLDISDLTFNTISLSEIMNMLWHRL 61

Query: 176 NDHGKNWRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVR 235
           NDHGKNWRHVYK++TLM+YLIK GS++V Q C+E    +QTLKDFQ++D  GKDQG  +R
Sbjct: 62  NDHGKNWRHVYKSLTLMDYLIKNGSKKVIQHCREGFCNLQTLKDFQHIDEAGKDQGYYIR 121

Query: 236 EKAKQLVALLRDEDRLREERAHALKTKEKLAQTATASSAAVGS 278
           EK+KQ++ LL DE  L +ER  A +T+++ + +   S   +GS
Sbjct: 122 EKSKQVITLLMDEPLLCKEREVACRTRQRTSHSILFSKRQLGS 164


>gi|156671219 epsin 2 isoform c [Homo sapiens]
          Length = 356

 Score =  189 bits (480), Expect = 7e-48
 Identities = 147/408 (36%), Positives = 186/408 (45%), Gaps = 102/408 (25%)

Query: 305 MSKEEADQEERIRRGDDLRLQMAIEESKRET----GGKEESSLMDLADVFTAPAPAPTTD 360
           MS+E A+QEER+RRGDDLRLQMA+EES+R+T      KE  SL     +       P++ 
Sbjct: 1   MSREVAEQEERLRRGDDLRLQMALEESRRDTVKIPKKKEHGSLPQQTTLLDLMDALPSSG 60

Query: 361 PWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPW-----RPAAPAGP 415
           P             AA  ++PWG        +PWGGPA   ++ DPW     +PAA    
Sbjct: 61  P-------------AAQKAEPWGPSASTNQTNPWGGPAAPASTSDPWPSFGTKPAA---- 103

Query: 416 SVDPWG-GTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSDPWGGSPAKPST 474
           S+DPWG  T A         DPW +S      +G  ASD W              A  +T
Sbjct: 104 SIDPWGVPTGATVQSVPKNSDPWAASQQPASSAGKRASDAW-------------GAVSTT 150

Query: 475 NGTTAAGGFD-------TEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGAFDM 527
              + +G F+       T  D+FS+FD LRT+  T+ S           +P+++ G    
Sbjct: 151 KPVSVSGSFELFSNLNGTIKDDFSEFDNLRTSKKTAES--------VTSLPSQNNGTTSP 202

Query: 528 SGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKAS 587
                       S P +A        RKTPESFLGPNAALV+LDSLV+RP P    A++ 
Sbjct: 203 DPFESQPLTVASSKPSSA--------RKTPESFLGPNAALVNLDSLVTRPAPP---AQSL 251

Query: 588 NPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPV----------------------- 624
           NPFL  G PAT   V NPFQ   P  LTLNQLR SPV                       
Sbjct: 252 NPFLAPGAPATSAPV-NPFQVNQPQPLTLNQLRGSPVLGTSTSFGPGPGVESMAVASMTS 310

Query: 625 ---PPVPGAPPTYISPLG-------GGPGLPPMMPPGPPAPNTNPFLL 662
               P  GA  + ++PLG       G  G+PP          TNPFLL
Sbjct: 311 AAPQPALGATGSSLTPLGPAMMNMVGSVGIPP--SAAQATGTTNPFLL 356


>gi|7661968 epsin 4 [Homo sapiens]
          Length = 625

 Score =  169 bits (429), Expect = 6e-42
 Identities = 86/175 (49%), Positives = 118/175 (67%), Gaps = 4/175 (2%)

Query: 123 NIVHNYSEAEIKVREATSNDPWGPSSSLMSEIADLTYNVVAFSEIMSMIWKR-LNDHGKN 181
           N+V NYSE E KVREAT++DPWGPS  LM EIA  T+    F E+M+M+W R L D+ KN
Sbjct: 16  NVVMNYSEIESKVREATNDDPWGPSGQLMGEIAKATFMYEQFPELMNMLWSRMLKDNKKN 75

Query: 182 WRHVYKAMTLMEYLIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVREKAKQL 241
           WR VYK++ L+ YLI+ GSERV    +E++Y +++L+++ +VD  GKDQG+N+R+K K+L
Sbjct: 76  WRRVYKSLLLLAYLIRNGSERVVTSAREHIYDLRSLENYHFVDEHGKDQGINIRQKVKEL 135

Query: 242 VALLRDEDRLREERAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQSSGEEE 296
           V   +D+DRLREER  A K K+K       SS +VG     E     P+S  +EE
Sbjct: 136 VEFAQDDDRLREERKKAKKNKDKY---VGVSSDSVGGFRYSERYDPEPKSKWDEE 187


>gi|163965366 nascent polypeptide-associated complex alpha subunit
            isoform a [Homo sapiens]
          Length = 2078

 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 107/365 (29%), Positives = 128/365 (35%), Gaps = 70/365 (19%)

Query: 351  TAPA---PAPTTDPWGGPAPMAAAVPTAAPTSDPWGGP---------PVPPAA---DPWG 395
            T PA   P+P   P   P P  A+ P AA    P G P         P  PAA    P G
Sbjct: 1010 TPPAVTPPSPKGSPAATPFPKGASTPPAATPPSPKGSPAATPLPKGAPTTPAATLPSPKG 1069

Query: 396  GPAPTPASGDPWRPAAP-----AGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPS 450
            GPA     G P  PAA       GP+     G P P A   P+P       GG+  + P 
Sbjct: 1070 GPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATPPSPK------GGL-ATPPH 1122

Query: 451  ASDPWTPAPAFSDPWGG--------SPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPT 502
               P TPA     P GG        +P  P+    +  GG  T P + +      T    
Sbjct: 1123 KGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSP 1182

Query: 503  SGSSAGELELLAGEVPARSP----GAFDMSGVRGSLAEAVGSPPPA----ATPTP----T 550
             G  A      A   PA +P    G       +G+      +PP      ATP+P    T
Sbjct: 1183 KGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPT 1242

Query: 551  PPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAK----------ASNPFL-----PGGG 595
             P    P    GP  A        + P  TPP  K          A NP +     P GG
Sbjct: 1243 TPAATPPSPKGGP--ATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGG 1300

Query: 596  PATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAP-PTYISPLG--GGPGLPPMMPPGP 652
            PAT P       P PPA    +       PP  GAP P  ++P    G P LP   P   
Sbjct: 1301 PATSPP---KGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTPPSPKGTPTLPATTPSSK 1357

Query: 653  PAPNT 657
              P T
Sbjct: 1358 GGPTT 1362



 Score = 92.0 bits (227), Expect = 2e-18
 Identities = 112/366 (30%), Positives = 132/366 (36%), Gaps = 75/366 (20%)

Query: 353  PAPAPTT------DPWGGPAPMA---AAVPTAAPTSDPWGGP--------PVPPAADPWG 395
            P  APTT       P GGPA  +   A  P AA    P GGP        P+PPAA P  
Sbjct: 1053 PKGAPTTPAATLPSPKGGPATPSLKGAPTPPAATPPSPKGGPATPSPKGAPMPPAATP-- 1110

Query: 396  GPAPTPASGDPWRPAAPAGPSVDP----WGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSA 451
             P+P      P    AP  P+  P     G    P  G   TP     S  G   + P  
Sbjct: 1111 -PSPKGGLATPPHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPK 1169

Query: 452  SDPWTPAPAFSDPWG--------GSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTS 503
              P TPA     P G        G+P  P+    +  GG  T   + +      T     
Sbjct: 1170 GAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPK 1229

Query: 504  GSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTP---TPPTRK----T 556
            G  A      A   PA +P        +G  A    +PPP   PTP   TPP+ K    T
Sbjct: 1230 GGLATPSPKGAPTTPAATP-----PSPKGGPA----TPPPKGAPTPPAATPPSLKGGLAT 1280

Query: 557  PESFLGPNAALVDLDSLVSRPGPTPP-GA---KASNPFLPGGGPATGPSVTNPFQPA--- 609
            P     PN A+V   S    P  +PP GA    A+ P  P G P T P    P  PA   
Sbjct: 1281 PPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPKGSPGTPPPKGAPTPPAVTP 1340

Query: 610  --PPATLTLNQLRLSPVPPVPGAPPTYISPLGGGP--------GLPPMMPPGP------P 653
              P  T TL     +  P   G P T  S  G  P        G P M PP P      P
Sbjct: 1341 PSPKGTPTLP----ATTPSSKGGPTTPSSKEGPTPPAATPSHKGGPAMTPPSPKRGPAIP 1396

Query: 654  APNTNP 659
            +P  +P
Sbjct: 1397 SPKGDP 1402



 Score = 90.1 bits (222), Expect = 6e-18
 Identities = 105/371 (28%), Positives = 135/371 (36%), Gaps = 85/371 (22%)

Query: 351  TAPAPAPTTDPWGG---PAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPAS---- 403
            T PA  P + P GG   P P  A    AA    P GG   PP       PA TP S    
Sbjct: 1127 TTPAATPPS-PKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGG 1185

Query: 404  ----GDPWRPAAPAGPSVDPWGGTPAPAAGEGPT------PDPWGS----SDGGVPVSGP 449
                     P  PA     P GG   P+    PT      P P G     S  G P + P
Sbjct: 1186 LATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTTPAATPPSPKGGLATPSPKGAPTT-P 1244

Query: 450  SASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGE 509
            +A+ P       + P  G+P  P+    +  GG  T P + +    + T     G  A  
Sbjct: 1245 AATPPSPKGGPATPPPKGAPTPPAATPPSLKGGLATPPHKGAPNPAVVTPPSPKGGPATS 1304

Query: 510  LELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTP---TPPTRK--------TPE 558
                A   PA +P +      +GS     G+PPP   PTP   TPP+ K        TP 
Sbjct: 1305 PPKGAPTPPAATPPS-----PKGS----PGTPPPKGAPTPPAVTPPSPKGTPTLPATTPS 1355

Query: 559  SFLGPNAALVDLDSLVSRPGPTPPGAKASN---PFLPGGGPATGPSVTNPF-QPAPPATL 614
            S  GP           S+ GPTPP A  S+   P +    P  GP++ +P   P  PA +
Sbjct: 1356 SKGGPTTPS-------SKEGPTPPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVI 1408

Query: 615  TLNQLRLSPVPPV---------------PGAPPTYI-------SPLGG--------GPGL 644
             L+  + +P  PV               P   P  +       +P GG         P L
Sbjct: 1409 PLSPKK-APATPVTREGAATPSKGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTL 1467

Query: 645  PPMMPPGPPAP 655
            P + PP P  P
Sbjct: 1468 PAVTPPSPKEP 1478



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 101/334 (30%), Positives = 117/334 (35%), Gaps = 51/334 (15%)

Query: 352  APAPAPTTDPWGGPAPMAAAVPT--AAPTSDPWGGPPVPPAA---DPWGGPA-PTPASGD 405
            AP  AP           A A P     P S    G P PPAA    P GGPA P+P    
Sbjct: 904  APKQAPALSMTSSSPKKARATPAPKGIPASPSPKGAPTPPAATPPSPKGGPATPSP---- 959

Query: 406  PWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDP-WTPAPAFSDP 464
             W P  PA     P GG   P+    PTP    ++    P  GP+   P   P P    P
Sbjct: 960  KWAPTPPAATPPSPKGGPATPSPKGAPTPP---AATPPSPKGGPATPSPKGAPTPPAVTP 1016

Query: 465  WGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGA 524
                   PS  G+ AA  F   P   S         P    +A  L   A   PA +   
Sbjct: 1017 -------PSPKGSPAATPF---PKGASTPPAATPPSPKGSPAATPLPKGAPTTPAAT--- 1063

Query: 525  FDMSGVRGSLA--EAVGSP-PPAATPTPTP---PTRKTPESFLGPNAAL--VDLDSLVSR 576
              +   +G  A     G+P PPAATP P+P   P   +P+    P AA        L + 
Sbjct: 1064 --LPSPKGGPATPSLKGAPTPPAATP-PSPKGGPATPSPKGAPMPPAATPPSPKGGLATP 1120

Query: 577  PGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSP---VPPVPGAPPT 633
            P    P   A+ P  P GG AT P    P  PA         L   P    P  P A P 
Sbjct: 1121 PHKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPPSPKGGLATPPPKGAPTTPAATPP 1180

Query: 634  YISPLG--------GGPGLPPMMPPGPPAPNTNP 659
              SP G        G P  P   PP P      P
Sbjct: 1181 --SPKGGLATPSPKGAPTTPAATPPSPKGGLATP 1212



 Score = 77.8 bits (190), Expect = 3e-14
 Identities = 93/331 (28%), Positives = 117/331 (35%), Gaps = 61/331 (18%)

Query: 351  TAPAPAPTTDPWGG---PAPMAAAVPTAAPTSDPWGGP--------PVPPAADP---WGG 396
            T PA  P + P GG   P+P  A    AA    P GGP        P PPAA P    GG
Sbjct: 1219 TTPAATPPS-PKGGLATPSPKGAPTTPAATPPSPKGGPATPPPKGAPTPPAATPPSLKGG 1277

Query: 397  PAPTPASGDP-----WRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSA 451
             A  P  G P       P+   GP+  P  G P P A   P+P        G P + P  
Sbjct: 1278 LATPPHKGAPNPAVVTPPSPKGGPATSPPKGAPTPPAATPPSPK-------GSPGTPPPK 1330

Query: 452  SDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSS-AGEL 510
              P  PA     P  G+P  P+T  ++  G                   PT+ SS  G  
Sbjct: 1331 GAPTPPAVTPPSP-KGTPTLPATTPSSKGG-------------------PTTPSSKEGPT 1370

Query: 511  ELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDL 570
               A       P     S  RG    +    P +    P  P +K P + +    A    
Sbjct: 1371 PPAATPSHKGGPAMTPPSPKRGPAIPSPKGDPTSPAVIPLSP-KKAPATPVTREGAATPS 1429

Query: 571  DSLVSRPGPTPPG-AKASNPFLPGGGPATG--------PSVTNPF---QPAPPATLTLNQ 618
               ++ P  TP    KA     P GGPAT         P+VT P     PAP    T + 
Sbjct: 1430 KGDLTPPAVTPVSLKKAPATSAPKGGPATPSSKGDPTLPAVTPPSPKEPPAPKQVATSSS 1489

Query: 619  LRLSPVPPVPGAPPTYISPLGGGPGLPPMMP 649
             + +P  P P   PT  + +   P   P  P
Sbjct: 1490 PKKAPATPAPMGAPTLPAVIPSSPKEVPATP 1520



 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 95/313 (30%), Positives = 106/313 (33%), Gaps = 56/313 (17%)

Query: 353  PAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDP-WRPAA 411
            P P+    P+    P A   P  AP        P    A P   P   PAS  P   P  
Sbjct: 886  PTPSVVNLPFPKEGP-ATPAPKQAPALSMTSSSPKKARATP--APKGIPASPSPKGAPTP 942

Query: 412  PAGPSVDPWGG--TPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSDPWGGSP 469
            PA     P GG  TP+P     P      S  GG     P  + P  PA     P GG P
Sbjct: 943  PAATPPSPKGGPATPSPKWAPTPPAATPPSPKGGPATPSPKGA-PTPPAATPPSPKGG-P 1000

Query: 470  AKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGAFDMSG 529
            A PS  G        T P             P    +A      A   PA +P       
Sbjct: 1001 ATPSPKGAPTPPAV-TPPS------------PKGSPAATPFPKGASTPPAATP-----PS 1042

Query: 530  VRGSLAEAVGSPPPAATP----TPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAK 585
             +GS         PAATP     PT P    P    GP    +       +  PTPP   
Sbjct: 1043 PKGS---------PAATPLPKGAPTTPAATLPSPKGGPATPSL-------KGAPTPP--- 1083

Query: 586  ASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYI----SPLGGG 641
            A+ P  P GGPAT PS      P PPA    +       PP  GAP T      SP GG 
Sbjct: 1084 AATPPSPKGGPAT-PSPKG--APMPPAATPPSPKGGLATPPHKGAPTTPAATPPSPKGGL 1140

Query: 642  PGLPPMMPPGPPA 654
               PP   P  PA
Sbjct: 1141 ATPPPKGAPTTPA 1153



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 104/379 (27%), Positives = 131/379 (34%), Gaps = 92/379 (24%)

Query: 351  TAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAA-DPWGGPAP-----TPASG 404
            ++P  AP T     PAPM A    A   S P   P  P +  DP    A      TPA+ 
Sbjct: 1488 SSPKKAPAT-----PAPMGAPTLPAVIPSSPKEVPATPSSRRDPIAPTATLLSKKTPATL 1542

Query: 405  DPWRPAAPAGPSVDPWGGTPA-PAAGEGPT----------PDPWGSSDGGVP-------- 445
             P     P   +V     TPA P   E P           P    S+  G P        
Sbjct: 1543 APKEALIPPAMTVPSPKKTPAIPTPKEAPATPSSKEASSPPAVTPSTYKGAPSPKELLIP 1602

Query: 446  --VSGPSASDPWTPAPAFSDPWGGS-PAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPT 502
              V+ PS  +  TP PA + P     PA P+  GT  +      P    D        PT
Sbjct: 1603 PAVTSPSPKEAPTP-PAVTPPSPEKGPATPAPKGTPTSP--PVTPSSLKDS-------PT 1652

Query: 503  SGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPES--- 559
            S +S      +   VP  S G     G   +L E + +P P +TP  T PTRK P++   
Sbjct: 1653 SPASV--TCKMGATVPQASKGLPAKKGPT-ALKEVLVAPAPESTPIITAPTRKGPQTKKS 1709

Query: 560  ----------------FLGPNAALVDL----------------DSLVSRPGP-TPPGAKA 586
                              GP + +                   D+  S  GP  PP +KA
Sbjct: 1710 SATSPPICPDPSAKNGSKGPLSTVAPAPLLPVQKDSSKTAKGKDASHSPKGPLAPPESKA 1769

Query: 587  SNPFLPGGGPATGP---SVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLGGGPG 643
            S P          P   S +    P+PP +L L     SPVP +P  P     P    PG
Sbjct: 1770 STPLTAAAFEKVLPKPESASVSAAPSPPVSLPLAP---SPVPTLP--PKQQFLP--SSPG 1822

Query: 644  LPPMMPPGPPAPNTNPFLL 662
            L    P  P AP     LL
Sbjct: 1823 LVLESPSKPLAPADEDELL 1841



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 90/340 (26%), Positives = 113/340 (33%), Gaps = 46/340 (13%)

Query: 339  EESSLMDLADVFTAPAPAPTT-DPWGGPAPMAAAV-PTAAPTSDPWGGPPVPPAADPWGG 396
            +E +L  L  V TA    P    P    AP+A  V     P S P   P +PPA  P G 
Sbjct: 691  KEGTLTTLPLVPTASENCPVAPSPQNTCAPLATLVLAPEIPKSVP--SPSLPPAGTPPGT 748

Query: 397  PAPTPASGDPWRPAAPAGPSVDPW--GGTPAPAAGEGP------TPDPWG---SSDGGVP 445
                  S         + P   P    G  A A+ +G       +P P G   S     P
Sbjct: 749  KKVDGISHTSALAPVASSPKECPTEDSGASATASSKGTLTYLADSPSPLGVSVSPQTKRP 808

Query: 446  VSGPSASDPWTPAPAFSDPWGGSPAKPS---TNGTTAAGGFDTEPDEFSDFDRLRTALPT 502
             +   ++ P TP    S P   SP + S    N  +  G  D+     S         PT
Sbjct: 809  PTKKGSAGPDTPIGNLSSPV--SPVEASFLPENSLSFQGSKDSPATTHS---------PT 857

Query: 503  SGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRK-TPESFL 561
              S  G          A +P A      +G       +P P+    P P     TP    
Sbjct: 858  PPSPKG----------APTPSAVTPLSPKGVTLPPKETPTPSVVNLPFPKEGPATPAPKQ 907

Query: 562  GPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRL 621
             P  ++       +R  P P G  AS    P G P T P+ T P     PAT +      
Sbjct: 908  APALSMTSSSPKKARATPAPKGIPASPS--PKGAP-TPPAATPPSPKGGPATPSPKWAPT 964

Query: 622  SP--VPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNTNP 659
             P   PP P   P   SP  G P  P   PP P      P
Sbjct: 965  PPAATPPSPKGGPATPSP-KGAPTPPAATPPSPKGGPATP 1003



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 70/302 (23%), Positives = 106/302 (35%), Gaps = 22/302 (7%)

Query: 370 AAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGTPAPAAG 429
           AA PT          PP+  ++ P     PT  +     P AP  PS         P + 
Sbjct: 450 AAAPTTTFEVATCVSPPM--SSGPISNIEPTSPAALVMAPVAPKEPSTQVATTLRIPVSP 507

Query: 430 EGPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGG------F 483
             P P+   +    V V  P+  D  T  PA  +   G+P  P+  G T           
Sbjct: 508 PLPDPEDLKNLPSSVLVKFPTQKDLQT-VPASLE---GAPFSPAQAGLTTKKDPTVLPLV 563

Query: 484 DTEPDEFSDFDRLRTA--LPTSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSP 541
              P     F    ++  +P S  +    + L   +P   P +   S +  + + +V   
Sbjct: 564 QAAPKNSPSFQSTSSSPEIPLSPEATLAKKSLGEPLPIGKPASSMTSPLGVNSSASVIKT 623

Query: 542 PPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPS 601
              A P    P  K+  S + P  A   L+S     G  P  AK ++ +     P    +
Sbjct: 624 DSYAGPDSAGPLLKS--SLITPTVAAFPLES-ADPAGVAPTTAKGTSTYTTTASPFLEGT 680

Query: 602 VTNPFQPAPPATLTLNQLRLSPVP----PVPGAPPTYISPLGGGPGLPPMMPPGPPAPNT 657
           V+   +  P    TL  L L P      PV  +P    +PL     L P +P   P+P+ 
Sbjct: 681 VSLAPKNHPVKEGTLTTLPLVPTASENCPVAPSPQNTCAPL-ATLVLAPEIPKSVPSPSL 739

Query: 658 NP 659
            P
Sbjct: 740 PP 741



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 78/330 (23%), Positives = 115/330 (34%), Gaps = 38/330 (11%)

Query: 352 APAPAPTT---DPWGGPAPMAA---AVPTA----APTSDP-WGGPPVPPAADPWGGP--A 398
           +P P+P+T    P   P P ++   A+P      APT  P   GPP+ PAA     P  A
Sbjct: 65  SPFPSPSTIASTPLEVPFPQSSSGTALPLGTAPEAPTFLPNLIGPPISPAALALASPMIA 124

Query: 399 P----TPASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSA-SD 453
           P    TP+S  P    A A  SV      P P     P       S   + +S P A S+
Sbjct: 125 PTLKGTPSSSAPLALVALAPHSVQKSSAFP-PNLLTSPPSVAVAESGSVITLSAPIAPSE 183

Query: 454 PWT-----PAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPT-----S 503
           P T     P+    +P  G+P+ P    T             S    L    PT     +
Sbjct: 184 PKTNLNKVPSEVVPNP-KGTPSPPCIVSTVPYHCVTPMASIQSGVASLPQTTPTTTLAIA 242

Query: 504 GSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGP 563
                +  + +  +  ++PG+  + G        V  P   +  T + P   + +   GP
Sbjct: 243 SPQVKDTTISSVLISPQNPGSLSLKG-------PVSPPAALSLSTQSLPVVTSSQKTAGP 295

Query: 564 NAALVDLDSLVSRPGPTPPGAKASNPFLPGGGP-ATGPSVTNPFQPAPPATLTLNQLRLS 622
           N       SL S   P    +  S   L   GP A              +T      + S
Sbjct: 296 NTPPDFPISLGSHLAPLHQSSFGSVQLLGQTGPSALSDPTVKTISVDHSSTGASYPSQRS 355

Query: 623 PVPPVPGAPPTYISPLGGGPGLPPMMPPGP 652
            +PP+P       + +   P + P +  GP
Sbjct: 356 VIPPLPSRNEVVPATVAAFPVVAPSVDKGP 385



 Score = 33.9 bits (76), Expect = 0.49
 Identities = 32/133 (24%), Positives = 50/133 (37%), Gaps = 13/133 (9%)

Query: 533 SLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLP 592
           S+  A+G P P   P  +P  ++ P S     +      ++ S P   P    +S   LP
Sbjct: 33  SVTAALGQPGPTLPPPCSPAPQQCPLSAANQASPFPSPSTIASTPLEVPFPQSSSGTALP 92

Query: 593 GG----GPATGPSVTNPFQPAPPATLTLNQLRLSPV---PPVPGAPPTYIS----PLGGG 641
            G     P   P++  P  P  PA L L    ++P     P   AP   ++     +   
Sbjct: 93  LGTAPEAPTFLPNLIGP--PISPAALALASPMIAPTLKGTPSSSAPLALVALAPHSVQKS 150

Query: 642 PGLPPMMPPGPPA 654
              PP +   PP+
Sbjct: 151 SAFPPNLLTSPPS 163


>gi|148762969 myeloid/lymphoid or mixed-lineage leukemia 2 [Homo
            sapiens]
          Length = 5537

 Score = 79.0 bits (193), Expect = 1e-14
 Identities = 91/327 (27%), Positives = 121/327 (37%), Gaps = 43/327 (13%)

Query: 353  PAPAPTTDPWG-GPA-PMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDP--WR 408
            PA  P+ DP+G  PA P+    PTA PT  P+  P   PA  P  G +  P +G P  + 
Sbjct: 2168 PAQVPSQDPFGLAPAYPLEPRFPTAPPTYPPYPSPTGAPAQPPMLGASSRPGAGQPGEFH 2227

Query: 409  PAAPAGP-----SVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSD 463
               P  P     + DP+     P+      P+  G       V G  AS+P    P F +
Sbjct: 2228 TTPPGTPRHQPSTPDPFLKPRCPSLDNLAVPESPG-------VGGGKASEPLLSPPPFGE 2280

Query: 464  PWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEV--PARS 521
                   K    G ++       P      D      P+SG+  G LEL   +V     +
Sbjct: 2281 SRKALEVKKEELGASSP---SYGPPNLGFVDS-----PSSGTHLGGLELKTPDVFKAPLT 2332

Query: 522  PGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRK---TPESFLGPNAALVDLDSLVSRPG 578
            P A  +      L      PPPA    P+PP+      P S+  P A       L  RP 
Sbjct: 2333 PRASQVEPQSPGLGLRPQEPPPAQALAPSPPSHPDIFRPGSYTDPYAQ----PPLTPRPQ 2388

Query: 579  PTPPGAKASNP--FLPGGG----PATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPP 632
            P PP +  + P   LP       PA+  S ++   P  P  L+      SPV P   +P 
Sbjct: 2389 PPPPESCCALPPRSLPSDPFSRVPASPQSQSSSQSPLTPRPLSAEAFCPSPVTPRFQSPD 2448

Query: 633  TY----ISPLGGGPGLPPMMPPGPPAP 655
             Y      P    P  P   PP P  P
Sbjct: 2449 PYSRPPSRPQSRDPFAPLHKPPRPQPP 2475



 Score = 59.7 bits (143), Expect = 8e-09
 Identities = 84/322 (26%), Positives = 114/322 (35%), Gaps = 69/322 (21%)

Query: 354 APAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPAAPA 413
           +P P   P   P       P ++P S     P  PP   P     P+PA   P  P   A
Sbjct: 495 SPPPEESPLSPP-------PESSPFSPLEESPLSPPEESP-----PSPALETPLSPPPEA 542

Query: 414 GPSVDPWGGTP-APAAGEGPTPDPWGSS-----DGGVPVSGPSASDPWTPAPAFS---DP 464
            P   P+  +P +P   E PT  P  +S         P+S P    P +P P  S    P
Sbjct: 543 SPLSPPFEESPLSPPPEELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEASRLFPP 602

Query: 465 WGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGA 524
           +  SP  P    +       + P E S     R + P   S            P  SP +
Sbjct: 603 FEESPLSPPPEESPL-----SPPPEAS-----RLSPPPEDSP-------MSPPPEESPMS 645

Query: 525 FDMSGVRGSLAEAVG--SPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPP 582
                 R S    V   SPPP  +P  +PP  ++P S                   P P 
Sbjct: 646 PPPEVSRLSPLPVVSRLSPPPEESPL-SPPPEESPTS-------------------PPPE 685

Query: 583 GAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLGGGP 642
            ++ S P  P   P + P   +P  P P  +L    L  SP+ P+P  P   + P   GP
Sbjct: 686 ASRLSPP--PEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLPLPEEP--QLCPRSEGP 741

Query: 643 GLPPM-----MPPGPPAPNTNP 659
            L P      + P P  P+ +P
Sbjct: 742 HLSPRPEEPHLSPRPEEPHLSP 763



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 78/300 (26%), Positives = 103/300 (34%), Gaps = 42/300 (14%)

Query: 373 PTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPW------RPAAPAGPSVDPWGGTPAP 426
           P   PT +P     V     P GG   +    +P       +P   AG  ++P     AP
Sbjct: 377 PGDTPTDEP-DALYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLGKAGVQLEPQ--LEAP 433

Query: 427 AAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPA---FSDPWGGSPAKPSTNGTTAAGGF 483
              E P   P   S    P+S P    P +P P     S P    PA P       +   
Sbjct: 434 LNEEMPLLPPPEES----PLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSRPL 489

Query: 484 DTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPP 543
           +  P      +    + P   S    LE      P  SP +           E   SPPP
Sbjct: 490 EESPLSPPP-EESPLSPPPESSPFSPLEESPLSPPEESPPS--------PALETPLSPPP 540

Query: 544 AATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVT 603
            A+P  +PP  ++P S   P   L         P   PP A   +P  P   P + P   
Sbjct: 541 EASPL-SPPFEESPLS--PPPEEL---------PTSPPPEASRLSP-PPEESPMSPPPEE 587

Query: 604 NPFQPAPPATLTLNQLRLSPVPPVPG----APPTYISPLGGGPGLPPMMPPGPPAPNTNP 659
           +P  P P A+        SP+ P P     +PP   S L   P   PM PP   +P + P
Sbjct: 588 SPMSPPPEASRLFPPFEESPLSPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPP 647



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 57/155 (36%), Positives = 64/155 (41%), Gaps = 51/155 (32%)

Query: 537  AVGSPPPAATPT-----PTPPT--RKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNP 589
            A+GSPPPAA PT     PT P     + + FL P A  V        PGP  PG      
Sbjct: 2112 ALGSPPPAAAPTIFIGSPTTPAGLSTSADGFLKPPAGSV--------PGPDSPGELFLK- 2162

Query: 590  FLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPT---YISPLGGGPGLPP 646
             LP   PA  PS  +PF  AP   L          P  P APPT   Y SP  G P  PP
Sbjct: 2163 -LPPQVPAQVPS-QDPFGLAPAYPLE---------PRFPTAPPTYPPYPSPT-GAPAQPP 2210

Query: 647  MM-----------------PPGPP--APNT-NPFL 661
            M+                 PPG P   P+T +PFL
Sbjct: 2211 MLGASSRPGAGQPGEFHTTPPGTPRHQPSTPDPFL 2245



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 70/247 (28%), Positives = 89/247 (36%), Gaps = 30/247 (12%)

Query: 426 PAAGEGPT--PDPWGSSDGGVPVSGPSAS-DPWTPAPAFSD--PWG--GSPAKPSTNGTT 478
           P  G+ PT  PD    +  G P  G   S  P  P P   +  P G  G   +P      
Sbjct: 375 PEPGDTPTDEPDALYVACQGQPKGGHVTSMQPKEPGPLQCEAKPLGKAGVQLEPQLEAPL 434

Query: 479 AAGGFDTEPDEFSDFDRLRTALPTSGS-SAGELELLAGEVPARS-PGAFDMSGVRGSLAE 536
                   P E S         PTS    A  L     E+PA   P A  +S     L E
Sbjct: 435 NEEMPLLPPPEESPLSPPPEESPTSPPPEASRLSPPPEELPASPLPEALHLSR---PLEE 491

Query: 537 AVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPG--G 594
           +  SPPP  +P  +PP   +P S L         +S +S P  +PP      P  P    
Sbjct: 492 SPLSPPPEESPL-SPPPESSPFSPLE--------ESPLSPPEESPPSPALETPLSPPPEA 542

Query: 595 GPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPG-APPTYISPLGGGPGLPPMMPPGPP 653
            P + P   +P  P P       +L  SP P     +PP   SP+   P   PM PP   
Sbjct: 543 SPLSPPFEESPLSPPP------EELPTSPPPEASRLSPPPEESPMSPPPEESPMSPPPEA 596

Query: 654 APNTNPF 660
           +    PF
Sbjct: 597 SRLFPPF 603



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 75/277 (27%), Positives = 100/277 (36%), Gaps = 51/277 (18%)

Query: 363  GGPAPMAAAVPTAAPTSDPWGGPPVPPAA--DPWG-----GPAPT----------PASGD 405
            G P+PM    P A    +P   PPVP      P G     GP PT           A+G+
Sbjct: 2529 GTPSPMRFTFPQAV--GEPSLKPPVPQPGLPPPHGINSHFGPGPTLGKPQSTNYTVATGN 2586

Query: 406  PWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDP---WTPAPAFS 462
                 +P GPS    G +   +    P+  P  + DG +P     AS      +P     
Sbjct: 2587 FHPSGSPLGPSSGSTGESYGLSPLRPPSVLPPPAPDGSLPYLSHGASQRSGITSPVEKRE 2646

Query: 463  DPWGGSPAK------PSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGE 516
            DP  G  +       P T     +G   TE ++     RLR             ELL  +
Sbjct: 2647 DPGTGMGSSLATAELPGTQDPGMSGLSQTELEKQRQRQRLR-------------ELLIRQ 2693

Query: 517  VPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSR 576
               R+    +      + A AVG PP +    P+ P  +       P A   D  SLV  
Sbjct: 2694 QIQRNTLRQEKE-TAAAAAGAVG-PPGSWGAEPSSPAFEQLSRGQTPFAGTQDKSSLVGL 2751

Query: 577  PGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPAT 613
                 P +K S P L   GP + PS     +P PPAT
Sbjct: 2752 -----PPSKLSGPIL---GPGSFPSDDRLSRPPPPAT 2780



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 88/336 (26%), Positives = 116/336 (34%), Gaps = 46/336 (13%)

Query: 353  PAPAPTTDPW-GGPA------PMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGD 405
            P   P+  P  G PA      P  + +P   P S P G P + P   P   P P P    
Sbjct: 885  PPGEPSLSPLLGEPALSEPGEPPLSPLPEELPLS-PSGEPSLSPQLMP---PDPLPPPLS 940

Query: 406  PWRPAAPAGPSVDPWGGTPAP--AAGEGPTPDPWGSSDGGVPVSGP---SASDPWTPAPA 460
            P   AA A P++ P G    P  A G+     P  +     P+S P   + +DP    P 
Sbjct: 941  PIITAA-APPALSPLGELEYPFGAKGDSDPESPLAAPILETPISPPPEANCTDPEPVPPM 999

Query: 461  FSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPAR 520
               P  GSP  P       A     EP        L+ +L    S   +    A  +   
Sbjct: 1000 ILPPSPGSPVGP-------ASPILMEPLPPQCSPLLQHSLVPQNSPPSQCSPPALPLSVP 1052

Query: 521  SP--------GAFDMSGVRGSLAEAVGSPP-PAATPTPTPPTRKTPESFLG-----PNAA 566
            SP        G  D + +     E V  P  PA  P+ T P   +P   L      P  A
Sbjct: 1053 SPLSPIGKVVGVSDEAELHEMETEKVSEPECPALEPSATSPL-PSPMGDLSCPAPSPAPA 1111

Query: 567  LVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPP 626
            L D   L     P   G  A     PG  P  G +  +       + + L+   L+PV P
Sbjct: 1112 LDDFSGLGEDTAPLD-GIDA-----PGSQPEPGQTPGSLASELKGSPVLLDPEELAPVTP 1165

Query: 627  VPGAPPTYISPLGGGPGLPPMMPPGPPAPNTNPFLL 662
            +   P    +   G P      P  P AP T P L+
Sbjct: 1166 MEVYPECKQTAGQGSPCEEQEEPRAPVAP-TPPTLI 1200



 Score = 38.9 bits (89), Expect = 0.015
 Identities = 83/346 (23%), Positives = 113/346 (32%), Gaps = 49/346 (14%)

Query: 354 APAPTTDPWGGP--APMAAAVPTAAPTSDPWGGPPV-PPAADPWGGPAPTPASGDPWRPA 410
           +P P   P   P  A   +  P  +P S P    P+ PP       P P  +   P    
Sbjct: 609 SPPPEESPLSPPPEASRLSPPPEDSPMSPPPEESPMSPPPEVSRLSPLPVVSRLSPPPEE 668

Query: 411 APAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDP---WTPAPAFSDPWGG 467
           +P  P  +    +P P A    +P P  S     P   P++  P       P    P   
Sbjct: 669 SPLSPPPEESPTSPPPEASR-LSPPPEDSPTSPPPEDSPASPPPEDSLMSLPLEESPLLP 727

Query: 468 SPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELEL----------LAGEV 517
            P +P     +        P+E       R   P     A E  L             E 
Sbjct: 728 LPEEPQLCPRSEGPHLSPRPEE--PHLSPRPEEPHLSPQAEEPHLSPQPEEPCLCAVPEE 785

Query: 518 PARSPGAFD--MSGVRGSLAEAVGSPPPAATPTPTPP-----------TRKTPESFLGPN 564
           P  SP A    +S     L  +  +  P  +P P  P           + ++ E  L P 
Sbjct: 786 PHLSPQAEGPHLSPQPEELHLSPQTEEPHLSPVPEEPCLSPQPEESHLSPQSEEPCLSPR 845

Query: 565 AALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPV 624
                L   + +P  +P   K   P  PG  PA       P    PP   +L+ L   P 
Sbjct: 846 PEESHLSPELEKPPLSPRPEKP--PEEPGQCPAPEELPLFP----PPGEPSLSPLLGEPA 899

Query: 625 PPVPGAPPTYISPL--------GGGPGLPP-MMPPGPPAPNTNPFL 661
              PG PP  +SPL         G P L P +MPP P  P  +P +
Sbjct: 900 LSEPGEPP--LSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPII 943



 Score = 37.7 bits (86), Expect = 0.034
 Identities = 67/277 (24%), Positives = 88/277 (31%), Gaps = 63/277 (22%)

Query: 388  PPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVS 447
            P + +P   P P  +   P     P  P  +     P    G+ P P+         P  
Sbjct: 835  PQSEEPCLSPRPEESHLSPELEKPPLSPRPEK----PPEEPGQCPAPEELPL----FPPP 886

Query: 448  GPSASDPWTPAPAFSDPWGGSPAKP-------STNGTTAAGGFDTEPDEFSD--FDRLRT 498
            G  +  P    PA S+P G  P  P       S +G  +       PD         +  
Sbjct: 887  GEPSLSPLLGEPALSEP-GEPPLSPLPEELPLSPSGEPSLSPQLMPPDPLPPPLSPIITA 945

Query: 499  ALPTSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPE 558
            A P + S  GELE   G      P     S +   + E   SPPP A  T          
Sbjct: 946  AAPPALSPLGELEYPFGAKGDSDPE----SPLAAPILETPISPPPEANCTD--------- 992

Query: 559  SFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQ 618
                              P P PP     +P     G   GP+     +P PP    L Q
Sbjct: 993  ------------------PEPVPPMILPPSP-----GSPVGPASPILMEPLPPQCSPLLQ 1029

Query: 619  LRLSPVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAP 655
              L P      +PP+  SP    P L P+  P P +P
Sbjct: 1030 HSLVP----QNSPPSQCSP----PAL-PLSVPSPLSP 1057



 Score = 36.6 bits (83), Expect = 0.076
 Identities = 46/189 (24%), Positives = 70/189 (37%), Gaps = 37/189 (19%)

Query: 279  GPPPEAEQAWP-----QSSGEEELQLQLALA-------MSKEEADQEERIRRGDDLRLQM 326
            GP  ++ Q  P      + G+   QLQ  LA       +S ++  Q + +     L+   
Sbjct: 4176 GPVLQSGQGLPGVGIMPTVGQLRAQLQGVLAKNPQLRHLSPQQQQQLQALLMQRQLQQSQ 4235

Query: 327  AIEESKR-ETGGKEESSLMDLADV------FTAPAPAPTTDPWGGPAPMAAA---VPTAA 376
            A+ ++   +  G + S L  L         F  P   P  +   GP P        P  A
Sbjct: 4236 AVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPGPQTGPLQELGAGPRPQGPPRLPAPPGA 4295

Query: 377  PTSDPWGGP--PVPPAADPW-----------GGPAPTPASGDPWRPAAPA--GPSVDPWG 421
             ++ P  GP  P PP + P                PT A   P  P  P   GP+++P  
Sbjct: 4296 LSTGPVLGPVHPTPPPSSPQEPKRPSQLPSPSSQLPTEAQLPPTHPGTPKPQGPTLEPPP 4355

Query: 422  GTPAPAAGE 430
            G  +PAA +
Sbjct: 4356 GRVSPAAAQ 4364



 Score = 36.6 bits (83), Expect = 0.076
 Identities = 42/134 (31%), Positives = 56/134 (41%), Gaps = 20/134 (14%)

Query: 535  AEAVGSPPPAATP-TPTPPTRKT----PE--SFLGPNAALVDLDSLVSRPG-----PTPP 582
            ++AV   PP   P T T P +      P+   F GP    +       RP      P PP
Sbjct: 4234 SQAVRQTPPYQEPGTQTSPLQGLLGCQPQLGGFPGPQTGPLQELGAGPRPQGPPRLPAPP 4293

Query: 583  GAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYI-SPLGGG 641
            GA ++ P L    P   PS  +P +P  P+ L       S +P     PPT+  +P   G
Sbjct: 4294 GALSTGPVLGPVHPTPPPS--SPQEPKRPSQLPSPS---SQLPTEAQLPPTHPGTPKPQG 4348

Query: 642  PGLPPMMPPGPPAP 655
            P L P  PPG  +P
Sbjct: 4349 PTLEP--PPGRVSP 4360



 Score = 33.9 bits (76), Expect = 0.49
 Identities = 51/210 (24%), Positives = 71/210 (33%), Gaps = 17/210 (8%)

Query: 346  LADVFTAPAPAPTTD------PWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAP 399
            L+ + TA AP   +       P+G         P AAP  +    P  PP       P P
Sbjct: 939  LSPIITAAAPPALSPLGELEYPFGAKGDSDPESPLAAPILET---PISPPPEANCTDPEP 995

Query: 400  TPASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAP 459
             P    P  P +P GP+  P    P P     P   P          S PS   P  PA 
Sbjct: 996  VPPMILPPSPGSPVGPA-SPILMEPLP-----PQCSPLLQHSLVPQNSPPSQCSP--PAL 1047

Query: 460  AFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPA 519
              S P   SP       +  A   + E ++ S+ +        +      +  L+   P+
Sbjct: 1048 PLSVPSPLSPIGKVVGVSDEAELHEMETEKVSEPECPALEPSATSPLPSPMGDLSCPAPS 1107

Query: 520  RSPGAFDMSGVRGSLAEAVGSPPPAATPTP 549
             +P   D SG+    A   G   P + P P
Sbjct: 1108 PAPALDDFSGLGEDTAPLDGIDAPGSQPEP 1137



 Score = 31.6 bits (70), Expect = 2.4
 Identities = 28/90 (31%), Positives = 38/90 (42%), Gaps = 13/90 (14%)

Query: 568  VDLDSLVSRPGPTP-PGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPP 626
            +D+ SL+ +  P P P  + S  +          S   P +P+PP          SP+ P
Sbjct: 4873 LDILSLLKQESPAPEPPTQHSYTYNVSNLDVRQLSAPPPEEPSPPP---------SPLAP 4923

Query: 627  VPGAPPTYISPLGGGPGLPPMMPPGP-PAP 655
             P +PPT   PL   P  P   PP P P P
Sbjct: 4924 SPASPPT--EPLVELPTEPLAEPPVPSPLP 4951



 Score = 30.0 bits (66), Expect = 7.1
 Identities = 23/68 (33%), Positives = 30/68 (44%), Gaps = 2/68 (2%)

Query: 348  DVFTAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPW 407
            DV    AP P  +P   P+P+A + P + PT      P  P A  P   P P  +S +  
Sbjct: 4902 DVRQLSAPPPE-EPSPPPSPLAPS-PASPPTEPLVELPTEPLAEPPVPSPLPLASSPESA 4959

Query: 408  RPAAPAGP 415
            RP   A P
Sbjct: 4960 RPKPRARP 4967


>gi|110832843 TBP-associated factor 4 [Homo sapiens]
          Length = 1085

 Score = 74.3 bits (181), Expect = 3e-13
 Identities = 104/345 (30%), Positives = 120/345 (34%), Gaps = 63/345 (18%)

Query: 363 GGPAPMAAAVPTAAPTSDPWGGPPVPPA--ADPWGGPAPTPASGDPWRPAAPAGPS---- 416
           G PA  A A P A     P   P  PPA  A P GG    P    P RP  PAGP+    
Sbjct: 65  GSPAGAAGAGPAAPAEGAPGAAPEPPPAGRARPGGGGPQRPGPPSPRRPLVPAGPAPPAA 124

Query: 417 ---VDPWGG----TPAPAA---GEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSDPWG 466
                P G      P PAA     GP P P G +    P +  + + P  P P      G
Sbjct: 125 KLRPPPEGSAGSCAPVPAAAAVAAGPEPAPAGPAKPAGPAALAARAGP-GPGPGPGPGPG 183

Query: 467 GSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALP-TSGSSAGELELLAGEVPARSPGAF 525
             P KP+       G   T     +  +    A P  S  + G   LL    PA +PG  
Sbjct: 184 PGPGKPA-----GPGAAQTLNGSAALLNSHHAAAPAVSLVNNGPAALLPLPKPA-APGTV 237

Query: 526 DMS----GVRGSLAEAVGSPP-------PAATPTPTPPT-------------RKTPESFL 561
             +    G     A A  SPP       PAA P P PP                T    +
Sbjct: 238 IQTPPFVGAAAPPAPAAPSPPAAPAPAAPAAAPPPPPPAPATLARPPGHPAGPPTAAPAV 297

Query: 562 GPNAALVDLDSLVSRPGPTP-PGAKASNPFLPGGG-----PATGPSVTNP---FQPAPPA 612
            P AA  +  S  + P P P  G  A     PG G     PA G    +P    Q APPA
Sbjct: 298 PPPAAAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAPAPGVKAESPKRVVQAAPPA 357

Query: 613 TLTLNQLRLSPVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNT 657
             T     L+   P   A    I P   G  LP      PPAP T
Sbjct: 358 AQT-----LAASGPASTAASMVIGPTMQG-ALPSPAAVPPPAPGT 396



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 86/327 (26%), Positives = 111/327 (33%), Gaps = 58/327 (17%)

Query: 353 PAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGP-PVPPAADPWGGPAPTPASG-----DP 406
           PAPA    P  GPA +AA    A P   P  GP P P    P G  A    +G     + 
Sbjct: 152 PAPAGPAKP-AGPAALAAR---AGPGPGPGPGPGPGPGPGKPAGPGAAQTLNGSAALLNS 207

Query: 407 WRPAAPA------GPS----------------VDPWGGTPAPAAGEGPTPDPWGSSDGGV 444
              AAPA      GP+                  P+ G  AP A   P+P          
Sbjct: 208 HHAAAPAVSLVNNGPAALLPLPKPAAPGTVIQTPPFVGAAAPPAPAAPSPPA-----APA 262

Query: 445 PVSGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSG 504
           P +  +A  P  PAPA      G PA P T            P   +       A P   
Sbjct: 263 PAAPAAAPPPPPPAPATLARPPGHPAGPPTAAPA------VPPPAAAQNGGSAGAAPAPA 316

Query: 505 SSAGELELLAGEVPARSPGAFDMSGVRGSLAEAV--GSPPPAATPTPTPPTRKTPESFLG 562
            +AG    ++G+    +  A    GV+    + V   +PP A T   + P        +G
Sbjct: 317 PAAGGPAGVSGQPGPGAAAAAPAPGVKAESPKRVVQAAPPAAQTLAASGPASTAASMVIG 376

Query: 563 PNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPAT-----LTLN 617
           P      +   +  P   PP A  +   LP G      +VT      P AT      TL 
Sbjct: 377 PT-----MQGALPSPAAVPPPAPGTPTGLPKGAAG---AVTQSLSRTPTATTSGIRATLT 428

Query: 618 QLRLSPVPPVPGAPPTYISPLGGGPGL 644
              L+P  P P   PT I      PG+
Sbjct: 429 PTVLAPRLPQPPQNPTNIQNFQLPPGM 455



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 93/344 (27%), Positives = 121/344 (35%), Gaps = 61/344 (17%)

Query: 352 APAPAPTTDPWGG----PAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPW 407
           AP     T P+ G    PAP A + P A   + P   PP PP       PAP   +  P 
Sbjct: 233 APGTVIQTPPFVGAAAPPAPAAPSPPAAPAPAAPAAAPPPPP-------PAPATLARPPG 285

Query: 408 RPAAP--AGPSVDPWGGTPAPA-----AGEGPTPDPWGSSDGGV---PVSGPSASDPWTP 457
            PA P  A P+V P    PA A     AG  P P P      GV   P  G +A+ P  P
Sbjct: 286 HPAGPPTAAPAVPP----PAAAQNGGSAGAAPAPAPAAGGPAGVSGQPGPGAAAAAP-AP 340

Query: 458 APAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPT--------SGSSAGE 509
                 P     A P    T AA G  +          ++ ALP+         G+  G 
Sbjct: 341 GVKAESPKRVVQAAPPAAQTLAASGPASTAASMVIGPTMQGALPSPAAVPPPAPGTPTGL 400

Query: 510 LELLAGEVP---ARSPGAFDMSGVRGSLAEAVGS---PPPAATPT-----PTPPTRKTPE 558
            +  AG V    +R+P A   SG+R +L   V +   P P   PT       PP      
Sbjct: 401 PKGAAGAVTQSLSRTPTA-TTSGIRATLTPTVLAPRLPQPPQNPTNIQNFQLPPGMVLVR 459

Query: 559 SFLG-----PNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPAT 613
           S  G     P  AL  +    ++    P    A  P  P   P    S       AP   
Sbjct: 460 SENGQLLMIPQQALAQMQ---AQAHAQPQTTMAPRPATPTSAPPVQISTVQ----APGTP 512

Query: 614 LTLNQLRLSPVPPVPGAPPTYISP---LGGGPGLPPMMPPGPPA 654
           +   Q+  + +        T + P   L   PG+ P +  G  A
Sbjct: 513 IIARQVTPTTIIKQVSQAQTTVQPSATLQRSPGVQPQLVLGGAA 556


>gi|72004269 tetra-peptide repeat homeobox [Homo sapiens]
          Length = 411

 Score = 72.4 bits (176), Expect = 1e-12
 Identities = 90/325 (27%), Positives = 122/325 (37%), Gaps = 45/325 (13%)

Query: 352 APAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGP------PVPPAADPWGGPAPTPASGD 405
           A A AP   P G    + AA PT       WGGP       +P A  P  GP P P  G 
Sbjct: 50  ASASAPQRGPSG---ILPAAEPTICSLHQAWGGPGCRAQKGIPAALSPGPGPIPAPIPG- 105

Query: 406 PWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSDPW 465
              PA   GP     G  P P  G    P P  +     P+ GP +     P P F  P 
Sbjct: 106 ---PAQIPGPLP---GSIPGPIPGPAQIPSPIPA-----PIPGPISGPVQIPGP-FRGPI 153

Query: 466 GGSPAKPSTNGTTAAGGFD-TEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGA 524
            G  + P+      +G F    P      +      P SG   G + +    +P   PG 
Sbjct: 154 PGPISGPAPIPGPISGPFSGPNPGPIPGPNPGPIPGPISGPIPGPISV---PIPGPIPGP 210

Query: 525 FDMSGVRGSLAEAVGSPPPAATPTPT--PPTRKTPESFLGPNAALV--DLDSLVSRPGPT 580
                + G ++     P P   P P   P     P    GPN  L+   +   +S PGP 
Sbjct: 211 -----ISGPISGPNPGPIPGPIPGPISGPNPGPIPGPISGPNPGLIPGPIPGPISGPGPI 265

Query: 581 PPGAKASNPFLPGGGPATGPS-VTNPFQPAPPATLTLNQLRLSPVPPVPGAPP---TYIS 636
             G   S   +PG G   GP  + +P +   P +L      L+P+   PG+ P   +  +
Sbjct: 266 -IGPIPSPAQIPGPGRLQGPGPILSPGRMRSPGSLP----GLAPILG-PGSGPGSGSVPA 319

Query: 637 PLGGGPGLPPMMPPGPPAPNTNPFL 661
           P+ G   LP   P  P +P+ + FL
Sbjct: 320 PIPGPGSLPAPAPLWPQSPDASDFL 344



 Score = 55.1 bits (131), Expect = 2e-07
 Identities = 39/113 (34%), Positives = 45/113 (39%), Gaps = 8/113 (7%)

Query: 350 FTAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRP 409
           F+ P P P   P  GP P   + P   P S P  GP   P + P  GP P P  G    P
Sbjct: 171 FSGPNPGPIPGPNPGPIPGPISGPIPGPISVPIPGPIPGPISGPISGPNPGPIPGP--IP 228

Query: 410 AAPAGPSVDPWGGT---PAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAP 459
              +GP+  P  G    P P    GP P P     G  P+ GP  S    P P
Sbjct: 229 GPISGPNPGPIPGPISGPNPGLIPGPIPGP---ISGPGPIIGPIPSPAQIPGP 278


>gi|239746149 PREDICTED: hypothetical protein LOC80164 [Homo
           sapiens]
          Length = 816

 Score = 72.0 bits (175), Expect = 2e-12
 Identities = 91/312 (29%), Positives = 118/312 (37%), Gaps = 51/312 (16%)

Query: 365 PAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPT--PASGDPWRPAAPAGP------S 416
           P+P A   P+A           +  +A P   PA +   A G P  PA P+ P      +
Sbjct: 211 PSPAARRRPSAGGGLQRPASRSLSSSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQA 270

Query: 417 VDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTP-APAFSDPWGGSPAKPSTN 475
           + P   TP P     P   P  SS    P++ PS S P +P AP         PA P + 
Sbjct: 271 LRPPQVTP-PRKDAAPALGPLSSS----PLATPSPSAPPSPSAPPSLQTLPSPPATPPSQ 325

Query: 476 GTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGAFDMSGVRGSLA 535
            TT+ G                + LP+       L  LA   P   P          +L 
Sbjct: 326 ATTSLGS--------PTLQATHSFLPSP-----PLSPLATPPPQAPPAL--------ALP 364

Query: 536 EAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGG 595
                P P A+P  +P    +P++   PNA  V L      P P+PP      PF P   
Sbjct: 365 PLQAPPSPPASPPLSPLATPSPQA---PNALAVHLLQAPFSPPPSPP---VQAPFSPPAS 418

Query: 596 PATGPSVTNPFQPAPPATLTLNQLRLSPVPPV-PGAPPTYISPLGGGPGL--PPMM---- 648
           P   PS T P Q APP +L    L++ P PP  P   P+   P    P L  PP+     
Sbjct: 419 PPVSPSATPPSQ-APP-SLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKP 476

Query: 649 -PPGPPAPNTNP 659
            P  PPA  T P
Sbjct: 477 PPQAPPALATPP 488



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 89/318 (27%), Positives = 116/318 (36%), Gaps = 40/318 (12%)

Query: 352 APAPAP-TTDPWGGPAPMAAAVPTAAPTSDPWGGPP-VPPAADPWGGPAPTPASGDPWRP 409
           APA  P ++ P   P+P A   P+A P+      PP  PP+       +PT  +   + P
Sbjct: 284 APALGPLSSSPLATPSPSAPPSPSAPPSLQTLPSPPATPPSQATTSLGSPTLQATHSFLP 343

Query: 410 AAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTP----APAFSDPW 465
           + P  P   P    P PA    P   P  S     P+S  +   P  P          P+
Sbjct: 344 SPPLSPLATPPPQAP-PALALPPLQAP-PSPPASPPLSPLATPSPQAPNALAVHLLQAPF 401

Query: 466 GGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGAF 525
              P+ P     +        P          +A P S  +   L     +VP   P + 
Sbjct: 402 SPPPSPPVQAPFSPPASPPVSP----------SATPPS-QAPPSLAAPPLQVPPSPPASP 450

Query: 526 DMSGVRGSLAEAVGSPPPAATP---TPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPP 582
            MS    S      +PPP A P      PP +  P     P  AL    +  S PG  P 
Sbjct: 451 PMS---PSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQALPSPPA--SFPGQAPF 505

Query: 583 GAKASNPFLP--GGGPATGPSVTNPF---QPAPPATLTLNQLRLSPVPPVPGAPPTYISP 637
              AS P  P     P   P +  P     P+PPA+ TL   R    PP PG P T +S 
Sbjct: 506 SPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRR---PPTPG-PDTSVS- 560

Query: 638 LGGGPGLPPMMPPGPPAP 655
              GP L   + PGPP P
Sbjct: 561 ---GPRLTLALAPGPPPP 575



 Score = 63.5 bits (153), Expect = 6e-10
 Identities = 92/320 (28%), Positives = 113/320 (35%), Gaps = 47/320 (14%)

Query: 365 PAPMAAAVPTAAPTSDPWGGPPVPPAADPWGG--------PAPTPASGDPWRPAAPAGPS 416
           PA  A  + T  P   P   PPV PAA    G        P    A G        + P 
Sbjct: 17  PAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAPR 76

Query: 417 VDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPS-ASDPWTPAPAFSDPWGGSPAKPSTN 475
             P   +  PA+G G    P  ++  G PVS P  AS    P P      G    + S  
Sbjct: 77  AGPTRTSRPPASGRGERAPPAKNTSPG-PVSSPGRASGTTRPGPL-----GQKGLRISAE 130

Query: 476 GTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPAR-SPGAFDMSGVRGSL 534
            T A G     P         R+AL     SAG     +G  P   SP     S   G+ 
Sbjct: 131 ETVARGKATEAPK--------RSAL-----SAGARRDTSGPTPGTPSPAMARRSRAAGT- 176

Query: 535 AEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPT-------PPGAKAS 587
              VG P PA +  P PPT    +S    +       S  +R  P+       P     S
Sbjct: 177 --EVGLPRPAPSARPRPPTEGPRKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLS 234

Query: 588 NPFLPGGGPA-TGPSVTN----PFQPAPPATLTLNQLRLSPV-PPVPGAPPTYISPLGGG 641
           +   P   PA +GPS       P  P+ P    L  LR   V PP   A P  + PL   
Sbjct: 235 SSATPLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPA-LGPLSSS 293

Query: 642 PGLPPMMPPGPPAPNTNPFL 661
           P   P  P  PP+P+  P L
Sbjct: 294 PLATP-SPSAPPSPSAPPSL 312



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 77/314 (24%), Positives = 103/314 (32%), Gaps = 47/314 (14%)

Query: 352 APAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPA- 410
           +P  +P   P   P+P A           P+  PP PP   P+  PA  P S     P+ 
Sbjct: 371 SPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQ 430

Query: 411 APAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGP----SASDPWTPAPAFSDPWG 466
           AP   +  P    P+P A    +P          P++ P    +   P  P    + P  
Sbjct: 431 APPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQLAKPPPQAPPALATPPLQ 490

Query: 467 GSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGA-- 524
             P+ P+    +  G     P        L T  P +        L     P  SP    
Sbjct: 491 ALPSPPA----SFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQA 546

Query: 525 ----------FDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLV 574
                       +SG R +LA A G PP        PP+R    +  GP     DL    
Sbjct: 547 PRRPPTPGPDTSVSGPRLTLALAPGPPP--------PPSRSPSSTLSGP-----DLAGHS 593

Query: 575 SRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPPV-----PG 629
           S    TP   +  +   P GG A  P          PA  +       P PP+     PG
Sbjct: 594 SSATSTPEELRGYDSG-PEGGAAASPPPDAELAACHPAAWS-----RGPAPPLAFRGAPG 647

Query: 630 APPTYISPLGGGPG 643
           AP  +  P   GPG
Sbjct: 648 APLPW--PPATGPG 659



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 40/141 (28%), Positives = 50/141 (35%), Gaps = 19/141 (13%)

Query: 352 APAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAAD--PWGGPAPTPASGDPWRP 409
           A AP P   P   P+   +    A  +S     P      D  P GG A +P        
Sbjct: 567 ALAPGPPPPPSRSPSSTLSGPDLAGHSSSATSTPEELRGYDSGPEGGAAASPPPDAELAA 626

Query: 410 AAPAGPSVDPWGGTPAPAA---GEGPTPDPW------GSSDGGVPVSGPSASDPWTPAPA 460
             PA      W   PAP     G    P PW      GS+DG   +      +  TPAP 
Sbjct: 627 CHPAA-----WSRGPAPPLAFRGAPGAPLPWPPATGPGSADGLCTIYETEGPESATPAPG 681

Query: 461 FSDPWGGSPAKPSTNGTTAAG 481
             DP    P+  ++ G  AAG
Sbjct: 682 ALDP---GPSPGTSGGKAAAG 699


>gi|116284392 mucin 2 precursor [Homo sapiens]
          Length = 5179

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 81/329 (24%), Positives = 114/329 (34%), Gaps = 71/329 (21%)

Query: 351  TAPAPAPTTD----PWGGPAPMAAAVPTAAPTSDPWGGPPV------PPAADPWGGPAPT 400
            T P+P PT+     P   P+P      T  PT+ P   PP+      PP   P   P  T
Sbjct: 1404 TTPSPPPTSTTTLPPTTTPSPPTTTTTTPPPTTTP--SPPITTTTTPPPTTTP-SPPIST 1460

Query: 401  PASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPA 460
              +  P    +P   +  P   TP+P      TP P  +       S P+ +    PA  
Sbjct: 1461 TTTPPPTTTPSPPTTTPSPPTTTPSPPTTTTTTPPPTTTP------SPPTTTPITPPAST 1514

Query: 461  FSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPAR 520
             + P   +P+ P+T  TT        P   +         PTS ++           P  
Sbjct: 1515 TTLPPTTTPSPPTTTTTTPPPTTTPSPPTTTPITP-----PTSTTTLP---------PTT 1560

Query: 521  SPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPT 580
            +P                 SPPP  T TP P T  +P +   P+   +   +      P+
Sbjct: 1561 TP-----------------SPPPTTTTTPPPTTTPSPPTTTTPSPPTITTTTPPPTTTPS 1603

Query: 581  PPGA------KASNPFLPGGGPATGPSVTNPF----QPAPPATLTLNQLRLSPVPPVPGA 630
            PP          + P  P   P T P+ T        P+PP T T      +P P    +
Sbjct: 1604 PPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTT-----TTPPPTTTPS 1658

Query: 631  PPTYISPLGGGPGLPPMMPPGPPAPNTNP 659
            PPT  +P       PP+     P P T P
Sbjct: 1659 PPTTTTP------SPPITTTTTPPPTTTP 1681



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 75/321 (23%), Positives = 108/321 (33%), Gaps = 56/321 (17%)

Query: 351  TAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPA 410
            T P+P PTT P   PA      PT  P+      PP      P     P+P +  P  P 
Sbjct: 1498 TTPSP-PTTTPITPPASTTTLPPTTTPS------PPTTTTTTPPPTTTPSPPTTTPITP- 1549

Query: 411  APAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAP----AFSDPWG 466
             P   +  P   TP+P      TP P          + PS     TP+P      + P  
Sbjct: 1550 -PTSTTTLPPTTTPSPPPTTTTTPPP---------TTTPSPPTTTTPSPPTITTTTPPPT 1599

Query: 467  GSPAKPSTNGTTAAGGFDTEPDEFSDFD--RLRTALPTSGSSAGELELLAGEVPARSPGA 524
             +P+ P+T  TT        P   +        T LP + + +          P  +P  
Sbjct: 1600 TTPSPPTTTTTTPPPTTTPSPPTTTPITPPTSTTTLPPTTTPSPPPTTTTTPPPTTTP-- 1657

Query: 525  FDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDS----LVSRPGPT 580
                           SPP   TP+P   T  TP     P++ +    S     ++ P PT
Sbjct: 1658 ---------------SPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTTMTTPSPT 1702

Query: 581  P-PGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLG 639
              P +  +    P       P  T    P+P  T +     ++ +PP   + P   +PL 
Sbjct: 1703 TTPSSPITTTTTPSSTTTPSPPPTTMTTPSPTTTPSPPTTTMTTLPPTTTSSPLTTTPL- 1761

Query: 640  GGPGLPPMMPPGPPAPNTNPF 660
                     PP    P  +PF
Sbjct: 1762 ---------PPSITPPTFSPF 1773



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 75/338 (22%), Positives = 103/338 (30%), Gaps = 37/338 (10%)

Query: 349  VFTAPAPAPTTDPWGGPAPMAAAVPTAA---PTSDPWGGPP---VPPAADPWGGPAPTPA 402
            + T     PT  P G   P    + T     PT  P G       P        P PTP 
Sbjct: 3925 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3984

Query: 403  SGD-PWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAF 461
                P         +V P   TP P   + PT  P  ++    P   P+ +   T  P  
Sbjct: 3985 GTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 4041

Query: 462  SD------PWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAG 515
            +       P       P+T   T        P          T + T+ +          
Sbjct: 4042 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 4101

Query: 516  EVPARSPGAFDMSGVRGSLAEAVGSPPPAATP-------TPTPPTRKTPESFLGPNAALV 568
            + P  +P     +          G+  P  TP       TPTP    TP     P    +
Sbjct: 4102 QTPTTTP--ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP----TPTGTQTPTTTPI 4155

Query: 569  DLDSLVSRPGPTPPGAKA--SNPFLPGGG--PATGPSVTNPFQPAPPATLTLNQLRLSPV 624
               + V+ P PTP G +   + P        P   P+ T    P   +T  + +L  S  
Sbjct: 4156 TTTTTVT-PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTGPPTHTSTAPIAELTTSNP 4214

Query: 625  PPVPGAPPT---YISPLGGGPGLPPMMPPGPPAPNTNP 659
            PP    P T     SPL     L   +PP     +T P
Sbjct: 4215 PPESSTPQTSRSTSSPLTESTTLLSTLPPAIEMTSTAP 4252



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 73/342 (21%), Positives = 103/342 (30%), Gaps = 42/342 (12%)

Query: 349  VFTAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWR 408
            + T P+P  TT     P    ++  T   T      P  PP       P  TP+      
Sbjct: 1685 ITTTPSPPTTTMTTPSPTTTPSSPITTTTTPSSTTTPSPPPTTMTTPSPTTTPSPPTTTM 1744

Query: 409  PAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPA--PAFSDPWG 466
               P   +  P   TP P +   PT  P+ ++    P         W  +  P F  P G
Sbjct: 1745 TTLPPTTTSSPLTTTPLPPSITPPTFSPFSTTTPTTPCVPLCNWTGWLDSGKPNFHKPGG 1804

Query: 467  GSPAKPSTNGTTAAGGFDTEPDEFSD--FDRLRTALPTSGSSAGELELLAGEVPARSPGA 524
             +       G   A         + D    +L   +    S    + L+      +  G 
Sbjct: 1805 DTELIGDVCGPGWAANISCRATMYPDVPIGQLGQTVVCDVS----VGLICKNEDQKPGGV 1860

Query: 525  FDMS-----GVRGSLAEAVGSPPPAATPT---PTPPT------------RKTPESFLGPN 564
              M+      +     E V  P    T T   PTPPT              TP     P 
Sbjct: 1861 IPMAFCLNYEINVQCCECVTQPTTMTTTTTENPTPPTTTPITTTTTVTPTPTPTGTQTPT 1920

Query: 565  AALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLT------LNQ 618
               +   + V+ P PTP G +      P   P T  +   P  P P  T T         
Sbjct: 1921 TTPITTTTTVT-PTPTPTGTQT-----PTTTPITTTTTVTP-TPTPTGTQTPTTTPITTT 1973

Query: 619  LRLSPVPPVPGAPPTYISPLGGGPGLPPM-MPPGPPAPNTNP 659
              ++P P   G      +P+     + P   P G   P T P
Sbjct: 1974 TTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2015



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 58/284 (20%), Positives = 78/284 (27%), Gaps = 11/284 (3%)

Query: 349  VFTAPAPAPTTDPWGGPAPMAAAVPTAA---PTSDPWGGPP---VPPAADPWGGPAPTPA 402
            + T     PT  P G   P    + T     PT  P G       P        P PTP 
Sbjct: 4017 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 4076

Query: 403  SGD-PWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAF 461
                P         +V P   TP P   + PT  P  ++    P   P+ +   T  P  
Sbjct: 4077 GTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 4133

Query: 462  SDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARS 521
            +         P+   T       T            T  PT+        +     P  +
Sbjct: 4134 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 4193

Query: 522  PGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTP 581
                        +AE   S PP  + TP   +R T          L  L   +      P
Sbjct: 4194 QTGPPTHTSTAPIAELTTSNPPPESSTPQT-SRSTSSPLTESTTLLSTLPPAIEMTSTAP 4252

Query: 582  PGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVP 625
            P    +     GG   + P  T    P  P   T      +P P
Sbjct: 4253 PSTPTAPTTTSGGHTLSPPPSTTTSPPGTPTRGTTTGSSSAPTP 4296



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 71/338 (21%), Positives = 97/338 (28%), Gaps = 43/338 (12%)

Query: 349  VFTAPAPAPTTDPWGGPAPMAAAVPTAA---PTSDPWGGPP---VPPAADPWGGPAPTPA 402
            + T     PT  P G   P    + T     PT  P G       P        P PTP 
Sbjct: 1924 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 1983

Query: 403  SGD-PWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAF 461
                P         +V P   TP P   + PT  P  ++    P   P+ +   T  P  
Sbjct: 1984 GTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 2040

Query: 462  SD------PWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAG 515
            +       P       P+T   T        P          T + T+ +          
Sbjct: 2041 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 2100

Query: 516  EVPARSPGAFDMSGVRGSLAEAVGSPPPA-------ATPTPTPPTRKTPESFLGPNAALV 568
            + P  +P     +           +P           TPTPTP   +TP +        V
Sbjct: 2101 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 2160

Query: 569  DLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLT------LNQLRLS 622
                    P PTP G +      P   P T  +   P  P P  T T           ++
Sbjct: 2161 -------TPTPTPTGTQT-----PTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTTVT 2207

Query: 623  PVPPVPGAPPTYISPLGGGPGLPPM-MPPGPPAPNTNP 659
            P P   G      +P+     + P   P G   P T P
Sbjct: 2208 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2245



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 71/338 (21%), Positives = 97/338 (28%), Gaps = 43/338 (12%)

Query: 349  VFTAPAPAPTTDPWGGPAPMAAAVPTAA---PTSDPWGGPP---VPPAADPWGGPAPTPA 402
            + T     PT  P G   P    + T     PT  P G       P        P PTP 
Sbjct: 2039 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2098

Query: 403  SGD-PWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAF 461
                P         +V P   TP P   + PT  P  ++    P   P+ +   T  P  
Sbjct: 2099 GTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 2155

Query: 462  SD------PWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAG 515
            +       P       P+T   T        P          T + T+ +          
Sbjct: 2156 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 2215

Query: 516  EVPARSPGAFDMSGVRGSLAEAVGSPPPA-------ATPTPTPPTRKTPESFLGPNAALV 568
            + P  +P     +           +P           TPTPTP   +TP +        V
Sbjct: 2216 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 2275

Query: 569  DLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLT------LNQLRLS 622
                    P PTP G +      P   P T  +   P  P P  T T           ++
Sbjct: 2276 -------TPTPTPTGTQT-----PTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTTVT 2322

Query: 623  PVPPVPGAPPTYISPLGGGPGLPPM-MPPGPPAPNTNP 659
            P P   G      +P+     + P   P G   P T P
Sbjct: 2323 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2360



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 71/338 (21%), Positives = 97/338 (28%), Gaps = 43/338 (12%)

Query: 349  VFTAPAPAPTTDPWGGPAPMAAAVPTAA---PTSDPWGGPP---VPPAADPWGGPAPTPA 402
            + T     PT  P G   P    + T     PT  P G       P        P PTP 
Sbjct: 2154 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2213

Query: 403  SGD-PWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAF 461
                P         +V P   TP P   + PT  P  ++    P   P+ +   T  P  
Sbjct: 2214 GTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 2270

Query: 462  SD------PWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAG 515
            +       P       P+T   T        P          T + T+ +          
Sbjct: 2271 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 2330

Query: 516  EVPARSPGAFDMSGVRGSLAEAVGSPPPA-------ATPTPTPPTRKTPESFLGPNAALV 568
            + P  +P     +           +P           TPTPTP   +TP +        V
Sbjct: 2331 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 2390

Query: 569  DLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLT------LNQLRLS 622
                    P PTP G +      P   P T  +   P  P P  T T           ++
Sbjct: 2391 -------TPTPTPTGTQT-----PTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTTVT 2437

Query: 623  PVPPVPGAPPTYISPLGGGPGLPPM-MPPGPPAPNTNP 659
            P P   G      +P+     + P   P G   P T P
Sbjct: 2438 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2475



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 71/338 (21%), Positives = 97/338 (28%), Gaps = 43/338 (12%)

Query: 349  VFTAPAPAPTTDPWGGPAPMAAAVPTAA---PTSDPWGGPP---VPPAADPWGGPAPTPA 402
            + T     PT  P G   P    + T     PT  P G       P        P PTP 
Sbjct: 2269 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2328

Query: 403  SGD-PWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAF 461
                P         +V P   TP P   + PT  P  ++    P   P+ +   T  P  
Sbjct: 2329 GTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 2385

Query: 462  SD------PWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAG 515
            +       P       P+T   T        P          T + T+ +          
Sbjct: 2386 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 2445

Query: 516  EVPARSPGAFDMSGVRGSLAEAVGSPPPA-------ATPTPTPPTRKTPESFLGPNAALV 568
            + P  +P     +           +P           TPTPTP   +TP +        V
Sbjct: 2446 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 2505

Query: 569  DLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLT------LNQLRLS 622
                    P PTP G +      P   P T  +   P  P P  T T           ++
Sbjct: 2506 -------TPTPTPTGTQT-----PTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTTVT 2552

Query: 623  PVPPVPGAPPTYISPLGGGPGLPPM-MPPGPPAPNTNP 659
            P P   G      +P+     + P   P G   P T P
Sbjct: 2553 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2590



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 71/338 (21%), Positives = 97/338 (28%), Gaps = 43/338 (12%)

Query: 349  VFTAPAPAPTTDPWGGPAPMAAAVPTAA---PTSDPWGGPP---VPPAADPWGGPAPTPA 402
            + T     PT  P G   P    + T     PT  P G       P        P PTP 
Sbjct: 2384 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2443

Query: 403  SGD-PWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAF 461
                P         +V P   TP P   + PT  P  ++    P   P+ +   T  P  
Sbjct: 2444 GTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 2500

Query: 462  SD------PWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAG 515
            +       P       P+T   T        P          T + T+ +          
Sbjct: 2501 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 2560

Query: 516  EVPARSPGAFDMSGVRGSLAEAVGSPPPA-------ATPTPTPPTRKTPESFLGPNAALV 568
            + P  +P     +           +P           TPTPTP   +TP +        V
Sbjct: 2561 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 2620

Query: 569  DLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLT------LNQLRLS 622
                    P PTP G +      P   P T  +   P  P P  T T           ++
Sbjct: 2621 -------TPTPTPTGTQT-----PTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTTVT 2667

Query: 623  PVPPVPGAPPTYISPLGGGPGLPPM-MPPGPPAPNTNP 659
            P P   G      +P+     + P   P G   P T P
Sbjct: 2668 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2705



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 71/338 (21%), Positives = 97/338 (28%), Gaps = 43/338 (12%)

Query: 349  VFTAPAPAPTTDPWGGPAPMAAAVPTAA---PTSDPWGGPP---VPPAADPWGGPAPTPA 402
            + T     PT  P G   P    + T     PT  P G       P        P PTP 
Sbjct: 2499 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2558

Query: 403  SGD-PWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAF 461
                P         +V P   TP P   + PT  P  ++    P   P+ +   T  P  
Sbjct: 2559 GTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 2615

Query: 462  SD------PWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAG 515
            +       P       P+T   T        P          T + T+ +          
Sbjct: 2616 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 2675

Query: 516  EVPARSPGAFDMSGVRGSLAEAVGSPPPA-------ATPTPTPPTRKTPESFLGPNAALV 568
            + P  +P     +           +P           TPTPTP   +TP +        V
Sbjct: 2676 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 2735

Query: 569  DLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLT------LNQLRLS 622
                    P PTP G +      P   P T  +   P  P P  T T           ++
Sbjct: 2736 -------TPTPTPTGTQT-----PTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTTVT 2782

Query: 623  PVPPVPGAPPTYISPLGGGPGLPPM-MPPGPPAPNTNP 659
            P P   G      +P+     + P   P G   P T P
Sbjct: 2783 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2820



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 71/338 (21%), Positives = 97/338 (28%), Gaps = 43/338 (12%)

Query: 349  VFTAPAPAPTTDPWGGPAPMAAAVPTAA---PTSDPWGGPP---VPPAADPWGGPAPTPA 402
            + T     PT  P G   P    + T     PT  P G       P        P PTP 
Sbjct: 2614 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2673

Query: 403  SGD-PWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAF 461
                P         +V P   TP P   + PT  P  ++    P   P+ +   T  P  
Sbjct: 2674 GTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 2730

Query: 462  SD------PWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAG 515
            +       P       P+T   T        P          T + T+ +          
Sbjct: 2731 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 2790

Query: 516  EVPARSPGAFDMSGVRGSLAEAVGSPPPA-------ATPTPTPPTRKTPESFLGPNAALV 568
            + P  +P     +           +P           TPTPTP   +TP +        V
Sbjct: 2791 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 2850

Query: 569  DLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLT------LNQLRLS 622
                    P PTP G +      P   P T  +   P  P P  T T           ++
Sbjct: 2851 -------TPTPTPTGTQT-----PTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTTVT 2897

Query: 623  PVPPVPGAPPTYISPLGGGPGLPPM-MPPGPPAPNTNP 659
            P P   G      +P+     + P   P G   P T P
Sbjct: 2898 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2935



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 71/338 (21%), Positives = 97/338 (28%), Gaps = 43/338 (12%)

Query: 349  VFTAPAPAPTTDPWGGPAPMAAAVPTAA---PTSDPWGGPP---VPPAADPWGGPAPTPA 402
            + T     PT  P G   P    + T     PT  P G       P        P PTP 
Sbjct: 2729 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2788

Query: 403  SGD-PWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAF 461
                P         +V P   TP P   + PT  P  ++    P   P+ +   T  P  
Sbjct: 2789 GTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 2845

Query: 462  SD------PWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAG 515
            +       P       P+T   T        P          T + T+ +          
Sbjct: 2846 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 2905

Query: 516  EVPARSPGAFDMSGVRGSLAEAVGSPPPA-------ATPTPTPPTRKTPESFLGPNAALV 568
            + P  +P     +           +P           TPTPTP   +TP +        V
Sbjct: 2906 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 2965

Query: 569  DLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLT------LNQLRLS 622
                    P PTP G +      P   P T  +   P  P P  T T           ++
Sbjct: 2966 -------TPTPTPTGTQT-----PTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTTVT 3012

Query: 623  PVPPVPGAPPTYISPLGGGPGLPPM-MPPGPPAPNTNP 659
            P P   G      +P+     + P   P G   P T P
Sbjct: 3013 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3050



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 71/338 (21%), Positives = 97/338 (28%), Gaps = 43/338 (12%)

Query: 349  VFTAPAPAPTTDPWGGPAPMAAAVPTAA---PTSDPWGGPP---VPPAADPWGGPAPTPA 402
            + T     PT  P G   P    + T     PT  P G       P        P PTP 
Sbjct: 2844 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 2903

Query: 403  SGD-PWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAF 461
                P         +V P   TP P   + PT  P  ++    P   P+ +   T  P  
Sbjct: 2904 GTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 2960

Query: 462  SD------PWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAG 515
            +       P       P+T   T        P          T + T+ +          
Sbjct: 2961 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 3020

Query: 516  EVPARSPGAFDMSGVRGSLAEAVGSPPPA-------ATPTPTPPTRKTPESFLGPNAALV 568
            + P  +P     +           +P           TPTPTP   +TP +        V
Sbjct: 3021 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 3080

Query: 569  DLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLT------LNQLRLS 622
                    P PTP G +      P   P T  +   P  P P  T T           ++
Sbjct: 3081 -------TPTPTPTGTQT-----PTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTTVT 3127

Query: 623  PVPPVPGAPPTYISPLGGGPGLPPM-MPPGPPAPNTNP 659
            P P   G      +P+     + P   P G   P T P
Sbjct: 3128 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3165



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 71/338 (21%), Positives = 97/338 (28%), Gaps = 43/338 (12%)

Query: 349  VFTAPAPAPTTDPWGGPAPMAAAVPTAA---PTSDPWGGPP---VPPAADPWGGPAPTPA 402
            + T     PT  P G   P    + T     PT  P G       P        P PTP 
Sbjct: 2959 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3018

Query: 403  SGD-PWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAF 461
                P         +V P   TP P   + PT  P  ++    P   P+ +   T  P  
Sbjct: 3019 GTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 3075

Query: 462  SD------PWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAG 515
            +       P       P+T   T        P          T + T+ +          
Sbjct: 3076 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 3135

Query: 516  EVPARSPGAFDMSGVRGSLAEAVGSPPPA-------ATPTPTPPTRKTPESFLGPNAALV 568
            + P  +P     +           +P           TPTPTP   +TP +        V
Sbjct: 3136 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 3195

Query: 569  DLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLT------LNQLRLS 622
                    P PTP G +      P   P T  +   P  P P  T T           ++
Sbjct: 3196 -------TPTPTPTGTQT-----PTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTTVT 3242

Query: 623  PVPPVPGAPPTYISPLGGGPGLPPM-MPPGPPAPNTNP 659
            P P   G      +P+     + P   P G   P T P
Sbjct: 3243 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3280



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 71/338 (21%), Positives = 97/338 (28%), Gaps = 43/338 (12%)

Query: 349  VFTAPAPAPTTDPWGGPAPMAAAVPTAA---PTSDPWGGPP---VPPAADPWGGPAPTPA 402
            + T     PT  P G   P    + T     PT  P G       P        P PTP 
Sbjct: 3074 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3133

Query: 403  SGD-PWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAF 461
                P         +V P   TP P   + PT  P  ++    P   P+ +   T  P  
Sbjct: 3134 GTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 3190

Query: 462  SD------PWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAG 515
            +       P       P+T   T        P          T + T+ +          
Sbjct: 3191 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 3250

Query: 516  EVPARSPGAFDMSGVRGSLAEAVGSPPPA-------ATPTPTPPTRKTPESFLGPNAALV 568
            + P  +P     +           +P           TPTPTP   +TP +        V
Sbjct: 3251 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 3310

Query: 569  DLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLT------LNQLRLS 622
                    P PTP G +      P   P T  +   P  P P  T T           ++
Sbjct: 3311 -------TPTPTPTGTQT-----PTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTTVT 3357

Query: 623  PVPPVPGAPPTYISPLGGGPGLPPM-MPPGPPAPNTNP 659
            P P   G      +P+     + P   P G   P T P
Sbjct: 3358 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3395



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 71/338 (21%), Positives = 97/338 (28%), Gaps = 43/338 (12%)

Query: 349  VFTAPAPAPTTDPWGGPAPMAAAVPTAA---PTSDPWGGPP---VPPAADPWGGPAPTPA 402
            + T     PT  P G   P    + T     PT  P G       P        P PTP 
Sbjct: 3189 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3248

Query: 403  SGD-PWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAF 461
                P         +V P   TP P   + PT  P  ++    P   P+ +   T  P  
Sbjct: 3249 GTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 3305

Query: 462  SD------PWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAG 515
            +       P       P+T   T        P          T + T+ +          
Sbjct: 3306 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 3365

Query: 516  EVPARSPGAFDMSGVRGSLAEAVGSPPPA-------ATPTPTPPTRKTPESFLGPNAALV 568
            + P  +P     +           +P           TPTPTP   +TP +        V
Sbjct: 3366 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 3425

Query: 569  DLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLT------LNQLRLS 622
                    P PTP G +      P   P T  +   P  P P  T T           ++
Sbjct: 3426 -------TPTPTPTGTQT-----PTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTTVT 3472

Query: 623  PVPPVPGAPPTYISPLGGGPGLPPM-MPPGPPAPNTNP 659
            P P   G      +P+     + P   P G   P T P
Sbjct: 3473 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3510



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 71/338 (21%), Positives = 97/338 (28%), Gaps = 43/338 (12%)

Query: 349  VFTAPAPAPTTDPWGGPAPMAAAVPTAA---PTSDPWGGPP---VPPAADPWGGPAPTPA 402
            + T     PT  P G   P    + T     PT  P G       P        P PTP 
Sbjct: 3304 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3363

Query: 403  SGD-PWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAF 461
                P         +V P   TP P   + PT  P  ++    P   P+ +   T  P  
Sbjct: 3364 GTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 3420

Query: 462  SD------PWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAG 515
            +       P       P+T   T        P          T + T+ +          
Sbjct: 3421 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 3480

Query: 516  EVPARSPGAFDMSGVRGSLAEAVGSPPPA-------ATPTPTPPTRKTPESFLGPNAALV 568
            + P  +P     +           +P           TPTPTP   +TP +        V
Sbjct: 3481 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 3540

Query: 569  DLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLT------LNQLRLS 622
                    P PTP G +      P   P T  +   P  P P  T T           ++
Sbjct: 3541 -------TPTPTPTGTQT-----PTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTTVT 3587

Query: 623  PVPPVPGAPPTYISPLGGGPGLPPM-MPPGPPAPNTNP 659
            P P   G      +P+     + P   P G   P T P
Sbjct: 3588 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3625



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 71/338 (21%), Positives = 97/338 (28%), Gaps = 43/338 (12%)

Query: 349  VFTAPAPAPTTDPWGGPAPMAAAVPTAA---PTSDPWGGPP---VPPAADPWGGPAPTPA 402
            + T     PT  P G   P    + T     PT  P G       P        P PTP 
Sbjct: 3419 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3478

Query: 403  SGD-PWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAF 461
                P         +V P   TP P   + PT  P  ++    P   P+ +   T  P  
Sbjct: 3479 GTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 3535

Query: 462  SD------PWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAG 515
            +       P       P+T   T        P          T + T+ +          
Sbjct: 3536 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 3595

Query: 516  EVPARSPGAFDMSGVRGSLAEAVGSPPPA-------ATPTPTPPTRKTPESFLGPNAALV 568
            + P  +P     +           +P           TPTPTP   +TP +        V
Sbjct: 3596 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 3655

Query: 569  DLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLT------LNQLRLS 622
                    P PTP G +      P   P T  +   P  P P  T T           ++
Sbjct: 3656 -------TPTPTPTGTQT-----PTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTTVT 3702

Query: 623  PVPPVPGAPPTYISPLGGGPGLPPM-MPPGPPAPNTNP 659
            P P   G      +P+     + P   P G   P T P
Sbjct: 3703 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3740



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 71/338 (21%), Positives = 97/338 (28%), Gaps = 43/338 (12%)

Query: 349  VFTAPAPAPTTDPWGGPAPMAAAVPTAA---PTSDPWGGPP---VPPAADPWGGPAPTPA 402
            + T     PT  P G   P    + T     PT  P G       P        P PTP 
Sbjct: 3534 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3593

Query: 403  SGD-PWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAF 461
                P         +V P   TP P   + PT  P  ++    P   P+ +   T  P  
Sbjct: 3594 GTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 3650

Query: 462  SD------PWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAG 515
            +       P       P+T   T        P          T + T+ +          
Sbjct: 3651 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 3710

Query: 516  EVPARSPGAFDMSGVRGSLAEAVGSPPPA-------ATPTPTPPTRKTPESFLGPNAALV 568
            + P  +P     +           +P           TPTPTP   +TP +        V
Sbjct: 3711 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 3770

Query: 569  DLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLT------LNQLRLS 622
                    P PTP G +      P   P T  +   P  P P  T T           ++
Sbjct: 3771 -------TPTPTPTGTQT-----PTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTTVT 3817

Query: 623  PVPPVPGAPPTYISPLGGGPGLPPM-MPPGPPAPNTNP 659
            P P   G      +P+     + P   P G   P T P
Sbjct: 3818 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3855



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 71/338 (21%), Positives = 97/338 (28%), Gaps = 43/338 (12%)

Query: 349  VFTAPAPAPTTDPWGGPAPMAAAVPTAA---PTSDPWGGPP---VPPAADPWGGPAPTPA 402
            + T     PT  P G   P    + T     PT  P G       P        P PTP 
Sbjct: 3649 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3708

Query: 403  SGD-PWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAF 461
                P         +V P   TP P   + PT  P  ++    P   P+ +   T  P  
Sbjct: 3709 GTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 3765

Query: 462  SD------PWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAG 515
            +       P       P+T   T        P          T + T+ +          
Sbjct: 3766 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 3825

Query: 516  EVPARSPGAFDMSGVRGSLAEAVGSPPPA-------ATPTPTPPTRKTPESFLGPNAALV 568
            + P  +P     +           +P           TPTPTP   +TP +        V
Sbjct: 3826 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 3885

Query: 569  DLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLT------LNQLRLS 622
                    P PTP G +      P   P T  +   P  P P  T T           ++
Sbjct: 3886 -------TPTPTPTGTQT-----PTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTTVT 3932

Query: 623  PVPPVPGAPPTYISPLGGGPGLPPM-MPPGPPAPNTNP 659
            P P   G      +P+     + P   P G   P T P
Sbjct: 3933 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 3970



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 71/338 (21%), Positives = 97/338 (28%), Gaps = 43/338 (12%)

Query: 349  VFTAPAPAPTTDPWGGPAPMAAAVPTAA---PTSDPWGGPP---VPPAADPWGGPAPTPA 402
            + T     PT  P G   P    + T     PT  P G       P        P PTP 
Sbjct: 3764 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3823

Query: 403  SGD-PWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAF 461
                P         +V P   TP P   + PT  P  ++    P   P+ +   T  P  
Sbjct: 3824 GTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 3880

Query: 462  SD------PWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAG 515
            +       P       P+T   T        P          T + T+ +          
Sbjct: 3881 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 3940

Query: 516  EVPARSPGAFDMSGVRGSLAEAVGSPPPA-------ATPTPTPPTRKTPESFLGPNAALV 568
            + P  +P     +           +P           TPTPTP   +TP +        V
Sbjct: 3941 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 4000

Query: 569  DLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLT------LNQLRLS 622
                    P PTP G +      P   P T  +   P  P P  T T           ++
Sbjct: 4001 -------TPTPTPTGTQT-----PTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTTVT 4047

Query: 623  PVPPVPGAPPTYISPLGGGPGLPPM-MPPGPPAPNTNP 659
            P P   G      +P+     + P   P G   P T P
Sbjct: 4048 PTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 4085



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 70/337 (20%), Positives = 96/337 (28%), Gaps = 44/337 (13%)

Query: 349  VFTAPAPAPTTDPWGGPAPMAAAVPTAA---PTSDPWGGPP---VPPAADPWGGPAPTPA 402
            + T     PT  P G   P    + T     PT  P G       P        P PTP 
Sbjct: 3879 ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPT 3938

Query: 403  SGD-PWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAF 461
                P         +V P   TP P   + PT  P  ++    P   P+ +   T  P  
Sbjct: 3939 GTQTPTTTPITTTTTVTP---TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPIT 3995

Query: 462  SD------PWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAG 515
            +       P       P+T   T        P          T + T+ +          
Sbjct: 3996 TTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGT 4055

Query: 516  EVPARSPGAFDMSGVRGSLAEAVGSPPPA-------ATPTPTPPTRKTPESFLGPNAALV 568
            + P  +P     +           +P           TPTPTP   +TP +        V
Sbjct: 4056 QTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTV 4115

Query: 569  DLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLT------LNQLRLS 622
                    P PTP G +      P   P T  +   P  P P  T T           ++
Sbjct: 4116 -------TPTPTPTGTQT-----PTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTTTVT 4162

Query: 623  PVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNTNP 659
            P P   G      +P+     + P   P P    T P
Sbjct: 4163 PTPTPTGTQTPTTTPITTTTTVTP--TPTPTGTQTGP 4197



 Score = 38.5 bits (88), Expect = 0.020
 Identities = 78/349 (22%), Positives = 111/349 (31%), Gaps = 51/349 (14%)

Query: 351  TAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPAS--GDPWR 408
            T P+P  TT P           PT  P+S     P  P        P  TP+S       
Sbjct: 1655 TTPSPPTTTTPSPPITTTTTPPPTTTPSSPITTTPSPPTTTMTTPSPTTTPSSPITTTTT 1714

Query: 409  PAAPAGPSVDPWG-GTPAPAAGEGPTPDPWGSSDGGVP---VSGPSASDPWTPA---PAF 461
            P++   PS  P    TP+P      TP P  ++   +P    S P  + P  P+   P F
Sbjct: 1715 PSSTTTPSPPPTTMTTPSPTT----TPSPPTTTMTTLPPTTTSSPLTTTPLPPSITPPTF 1770

Query: 462  SDPWGGSPAKPSTNGTTAAGGFDTEPDEF----SDFDRLRTAL-PTSGSSAGELELLAGE 516
            S     +P  P        G  D+    F     D + +     P   ++      +  +
Sbjct: 1771 SPFSTTTPTTPCVPLCNWTGWLDSGKPNFHKPGGDTELIGDVCGPGWAANISCRATMYPD 1830

Query: 517  VPARSPGAFDMSGVR-GSLAEAVGSPPPAATP------------------TPTPPTRKTP 557
            VP    G   +  V  G + +     P    P                   PT  T  T 
Sbjct: 1831 VPIGQLGQTVVCDVSVGLICKNEDQKPGGVIPMAFCLNYEINVQCCECVTQPTTMTTTTT 1890

Query: 558  ESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLT-- 615
            E+   P    +   + V+ P PTP G +      P   P T  +   P  P P  T T  
Sbjct: 1891 ENPTPPTTTPITTTTTVT-PTPTPTGTQT-----PTTTPITTTTTVTP-TPTPTGTQTPT 1943

Query: 616  ----LNQLRLSPVPPVPGAPPTYISPLGGGPGLPPM-MPPGPPAPNTNP 659
                     ++P P   G      +P+     + P   P G   P T P
Sbjct: 1944 TTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 1992



 Score = 36.2 bits (82), Expect = 0.099
 Identities = 59/281 (20%), Positives = 84/281 (29%), Gaps = 40/281 (14%)

Query: 399  PTPASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPA 458
            PTP +  P        P       TP P   + PT  P  ++    P   P+ +   T  
Sbjct: 1893 PTPPTTTPITTTTTVTP-------TPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTT 1945

Query: 459  PAFS------DPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELEL 512
            P  +       P       P+T   T        P          T + T+ +       
Sbjct: 1946 PITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTPTP 2005

Query: 513  LAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATP-------TPTPPTRKTPESFLGPNA 565
               + P  +P     +          G+  P  TP       TPTP    TP     P  
Sbjct: 2006 TGTQTPTTTP--ITTTTTVTPTPTPTGTQTPTTTPITTTTTVTPTP----TPTGTQTPTT 2059

Query: 566  ALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLT------LNQL 619
              +   + V+ P PTP G +      P   P T  +   P  P P  T T          
Sbjct: 2060 TPITTTTTVT-PTPTPTGTQT-----PTTTPITTTTTVTP-TPTPTGTQTPTTTPITTTT 2112

Query: 620  RLSPVPPVPGAPPTYISPLGGGPGLPPM-MPPGPPAPNTNP 659
             ++P P   G      +P+     + P   P G   P T P
Sbjct: 2113 TVTPTPTPTGTQTPTTTPITTTTTVTPTPTPTGTQTPTTTP 2153


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo
           sapiens]
          Length = 1124

 Score = 71.6 bits (174), Expect = 2e-12
 Identities = 88/355 (24%), Positives = 117/355 (32%), Gaps = 65/355 (18%)

Query: 350 FTAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPP---AADPWGGPAPTPASGDP 406
           F   +P  T      P+  A+  P + P   P   P  PP   +  P   P  +P +  P
Sbjct: 429 FLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHP 488

Query: 407 WR---------PAAP---------------AGPSVD-PWGGTPAPAAGEGPTPDPWGSSD 441
            +         P AP               A PS+  P      P     P+  P     
Sbjct: 489 LQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLTTPPLENLPSLAPPPLQT 548

Query: 442 GGVPVSGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALP 501
              P++ P    P  PAP    P    P+  +T          T P +         + P
Sbjct: 549 ASAPLTTPHLETPPCPAPC---PLQAPPSPLTTPPPETPSSIATPPPQAPP---ALASPP 602

Query: 502 TSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFL 561
             G  +  L  LA   P   P          +L      P P A+P  +P    +P++  
Sbjct: 603 LQGLPSPPLSPLATPPPQAPPXL--------ALPPLQAPPSPPASPPLSPLATPSPQA-- 652

Query: 562 GPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQ-------------P 608
            PNA  V L      P P+PP      PF P   P   PS T P Q             P
Sbjct: 653 -PNALAVHLLQAPFSPPPSPP---VQAPFSPPASPPVSPSATPPSQAPPSLAAPPLQVPP 708

Query: 609 APPATLTLNQLRLSP--VPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNTNPFL 661
           +PPA+  ++     P   PP   APP  + P    P  PPM P   P P   P L
Sbjct: 709 SPPASPPMSPSATPPPQAPPPLAAPPLQVPP--SPPASPPMSPSATPPPRVPPLL 761



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 88/329 (26%), Positives = 108/329 (32%), Gaps = 82/329 (24%)

Query: 342 SLMDLADVFTAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTP 401
           +L  LA      A AP T P     P  A  P  AP S         P   P   P  TP
Sbjct: 537 NLPSLAPPPLQTASAPLTTPHLETPPCPAPCPLQAPPS---------PLTTP---PPETP 584

Query: 402 ASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAF 461
           +S     P AP   +  P  G P+P      TP P       +P           P  A 
Sbjct: 585 SSIATPPPQAPPALASPPLQGLPSPPLSPLATPPPQAPPXLALP-----------PLQAP 633

Query: 462 SDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARS 521
             P    P  P                       L T  P + ++     L A   P  S
Sbjct: 634 PSPPASPPLSP-----------------------LATPSPQAPNALAVHLLQAPFSPPPS 670

Query: 522 PGAFDMSGVRGSLAEAVGSPP--PAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGP 579
           P             +A  SPP  P  +P+ TPP++  P              SL + P  
Sbjct: 671 PP-----------VQAPFSPPASPPVSPSATPPSQAPP--------------SLAAPPLQ 705

Query: 580 TPPGAKASNPFLPGGGP---ATGPSVTNPFQ--PAPPATLTLNQLRLSP--VPPVPGAPP 632
            PP   AS P  P   P   A  P    P Q  P+PPA+  ++     P  VPP+  APP
Sbjct: 706 VPPSPPASPPMSPSATPPPQAPPPLAAPPLQVPPSPPASPPMSPSATPPPRVPPLLAAPP 765

Query: 633 TYISPLGGGPGLPPMMPPGPPAPNTNPFL 661
             + P    P   PM P   P P   P L
Sbjct: 766 LQVPP--SPPASLPMSPLAKPPPQAPPAL 792



 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 80/311 (25%), Positives = 101/311 (32%), Gaps = 69/311 (22%)

Query: 352 APAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPA- 410
           +P  +P   P   P+P A           P+  PP PP   P+  PA  P S     P+ 
Sbjct: 635 SPPASPPLSPLATPSPQAPNALAVHLLQAPFSPPPSPPVQAPFSPPASPPVSPSATPPSQ 694

Query: 411 APAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSDPWGGSPA 470
           AP   +  P    P+P A    +P          P++ P    P  P+P  S P   S  
Sbjct: 695 APPSLAAPPLQVPPSPPASPPMSPSATPPPQAPPPLAAPPLQVP--PSPPASPPMSPSAT 752

Query: 471 KPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGAFDMSGV 530
            P                       L  A P              +VP   P +  MS  
Sbjct: 753 PPPR------------------VPPLLAAPPL-------------QVPPSPPASLPMS-- 779

Query: 531 RGSLAEAVGSPPPAATPT-PTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNP 589
                  +  PPP A P   TPP +  P     P A+          PG  P    AS P
Sbjct: 780 ------PLAKPPPQAPPALATPPLQALPS----PPASF---------PGQAPFSPSASLP 820

Query: 590 FLPGGGPA--TGPSVTNPF---QPAPPATLTLNQLRLSPVPPVPGAPPTYISP-----LG 639
             P   P     P +  P     P+PPA+ TL   R    PP PG   +   P     L 
Sbjct: 821 MSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQAPRR---PPTPGPDTSVSGPRLTLALA 877

Query: 640 GGPGLPPMMPP 650
            GP  PP   P
Sbjct: 878 PGPPPPPSRSP 888



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 82/324 (25%), Positives = 110/324 (33%), Gaps = 41/324 (12%)

Query: 353 PAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGP--APTPASGDPWRPA 410
           PA  P + P   P P+A   P+A P+       P PPA  P   P    TP    P  P+
Sbjct: 328 PATLPPSPPLATPLPLAPPSPSAPPSLQTL---PSPPATPPSQAPPSMTTPPMQAP--PS 382

Query: 411 APAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDP---WTPAPAFSDPWGG 467
               P +       +P+    P+P    S      +  P+        T +P  +     
Sbjct: 383 LQTIPPIQVPHSLTSPSLQAPPSPLALSSLQATTSLGSPTLQATHSFLTMSPRQTQASLT 442

Query: 468 SPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGAFDM 527
           SP++P++          T PD       L+  L    S   +  L     P  SP     
Sbjct: 443 SPSRPAS----------TPPDS----PPLQAPLSLPASPPLQTSLSPAVSPLSSPLTIHP 488

Query: 528 SGVRGSLAEAVGSPPPAATPTPTPPTRKT--PESFLGPNAALVDLDSLVSRPGPTPPGAK 585
                SLA      P ++   P   T+ +  P S   P A+L     L + P   PP   
Sbjct: 489 LQALSSLASHSPQAPLSSLIMPPLETQSSLAPPSLQTPPASLT-TPPLENLPSLAPP--- 544

Query: 586 ASNPFLPGGGPATGPSVTNPFQPAP--------PATLTLNQLRLSPVPPVPGAPPTYISP 637
              P      P T P +  P  PAP        P T    +   S   P P APP   SP
Sbjct: 545 ---PLQTASAPLTTPHLETPPCPAPCPLQAPPSPLTTPPPETPSSIATPPPQAPPALASP 601

Query: 638 LGGGPGLPPMMPPGPPAPNTNPFL 661
              G   PP+ P   P P   P L
Sbjct: 602 PLQGLPSPPLSPLATPPPQAPPXL 625



 Score = 60.1 bits (144), Expect = 6e-09
 Identities = 95/347 (27%), Positives = 125/347 (36%), Gaps = 44/347 (12%)

Query: 351 TAPAPAP---TTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGG--PAPTPASGD 405
           T  A AP   T  P G P P     P A       G     P A+  GG   A  P S  
Sbjct: 16  TPAARAPGLLTPRPPGSPRPPPPVTPAALRVLGAAGAVGRKPLAERAGGIGGATIPESAP 75

Query: 406 PWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPS-ASDPWTPAPAFSDP 464
              P   AG S       P PA+G G    P  ++  G PVS P  AS    P P     
Sbjct: 76  RAGPTRSAGTSSRNPASRP-PASGRGERAPPAKNTSPG-PVSSPGRASGTTRPGPL---- 129

Query: 465 WGGSPAKPSTNGTTAAGGFDTEPDE--FSDFDRLRTALPTSGSSAGEL---ELLAGE--- 516
            G    + S   T A G     P     S   R  T+ PT G+ +  +      AG    
Sbjct: 130 -GQKGLRISAEETVARGKATEAPKRSALSAGARRDTSGPTPGTPSPAMARRSRAAGTEVG 188

Query: 517 VPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLG----PNAALVDLDS 572
           +P  +P A       G   ++V S    +T  P+P  R+ P +  G     + +L    +
Sbjct: 189 LPRPAPSARPRPPTEGP-RKSVSSASEHSTTEPSPAARRRPSAGGGLQRPASRSLSSSAT 247

Query: 573 LVSRPGPTPPGAKA--------SNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLS-- 622
            +S P  + P A+         S P   G      P VT P + A PA   L+   L+  
Sbjct: 248 PLSSPARSGPSARGTPRAPAHPSQPKPKGLQALRPPQVTPPRKDAAPALGPLSSSPLATP 307

Query: 623 --------PVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNTNPFL 661
                   PVPP   A     + L   P L   +P  PP+P+  P L
Sbjct: 308 SPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSL 354



 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 77/309 (24%), Positives = 110/309 (35%), Gaps = 40/309 (12%)

Query: 352 APAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWR--P 409
           +P  +P+  P     P  AA P   P S P   PP+ P+A P    AP P +  P +  P
Sbjct: 682 SPPVSPSATPPSQAPPSLAAPPLQVPPSPP-ASPPMSPSATP-PPQAPPPLAAPPLQVPP 739

Query: 410 AAPAGPSVDPWGGTPA---PAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSDPWG 466
           + PA P + P    P    P     P   P  S    +P+S  +   P  P    + P  
Sbjct: 740 SPPASPPMSPSATPPPRVPPLLAAPPLQVP-PSPPASLPMSPLAKPPPQAPPALATPPLQ 798

Query: 467 GSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGA-- 524
             P+ P++      G     P        L T  P +        L     P  SP    
Sbjct: 799 ALPSPPAS----FPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSPPASPTLQA 854

Query: 525 ----------FDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLV 574
                       +SG R +LA A G PPP   P+ +P +  +     G +++       +
Sbjct: 855 PRRPPTPGPDTSVSGPRLTLALAPGPPPP---PSRSPSSTLSGPDLAGHSSSATSTPEEL 911

Query: 575 SRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTY 634
                 P G  A++P       A  P+  +   PAPP        R +P  P+P  P T 
Sbjct: 912 RGYDSGPEGGAAASPPPDAELAACHPAAWSR-GPAPPLA-----FRGAPGAPLPWPPAT- 964

Query: 635 ISPLGGGPG 643
                 GPG
Sbjct: 965 ------GPG 967



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 80/300 (26%), Positives = 103/300 (34%), Gaps = 49/300 (16%)

Query: 353  PAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPAAP 412
            P+P P + P   P   +A++P +   + P   PPV  A      P+P PAS     P  P
Sbjct: 801  PSP-PASFPGQAPFSPSASLPMSPLATPPPQAPPVLAAPLLQVPPSP-PASPTLQAPRRP 858

Query: 413  AGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSDPWGGSPAKP 472
              P  D     P       P P P  S      +SGP             D  G S +  
Sbjct: 859  PTPGPDTSVSGPRLTLALAPGPPPPPSRSPSSTLSGP-------------DLAGHSSSAT 905

Query: 473  STNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAG---ELELLAGEVPARSPGAFDMSG 529
            ST            P+E   +D    + P  G++A    + EL A    A S G      
Sbjct: 906  ST------------PEELRGYD----SGPEGGAAASPPPDAELAACHPAAWSRGPAPPLA 949

Query: 530  VRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNP 589
             RG  A     P P AT   +     T     GP +A     +L   P P   G KA+  
Sbjct: 950  FRG--APGAPLPWPPATGPGSADGLCTIYETEGPESATPAPGALDPGPSPGTSGGKAA-- 1005

Query: 590  FLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPP------VPGAPPTYISPLGGGPG 643
                 G   G S  +P Q A    L L  L+ S V        +  A        GGGPG
Sbjct: 1006 ----AGAGAGASSRSPKQ-ARLGELPLGALQASVVQHLLSRTLLLAAAEGAAGGSGGGPG 1060


>gi|146219843 Snf2-related CBP activator protein [Homo sapiens]
          Length = 3230

 Score = 71.2 bits (173), Expect = 3e-12
 Identities = 85/360 (23%), Positives = 122/360 (33%), Gaps = 57/360 (15%)

Query: 351  TAPAPAPTTDPWGGPA------PMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASG 404
            ++P P P + P   P       P+++++P + PT+ P   P   P   P   P    ASG
Sbjct: 1412 SSPMPIPNSSPLASPVSSTVSVPLSSSLPISVPTTLP--APASAPLTIPISAPLTVSASG 1469

Query: 405  D--------PWRPAAPAG---PSVDPWGGTPAPAA---GEGPTPDPWGSSDGGVPV---- 446
                     P  P  PA    PS+ P G +P+ +A   G    P    S   G P+    
Sbjct: 1470 PALLTSVTPPLAPVVPAAPGPPSLAPSGASPSASALTLGLATAPSLSSSQTPGHPLLLAP 1529

Query: 447  -----------SGPSASDPWTPAPAFSDPWGGSPAKPSTNGT---TAAGGFDTEPDEFSD 492
                         P+ S    PA A + P+  +P       +    A+          + 
Sbjct: 1530 TSSHVPGLNSTVAPACSPVLVPASALASPFPSAPNPAPAQASLLAPASSASQALATPLAP 1589

Query: 493  FDRLRTA------------LPTSGSSAGELELLAGE---VPARSPGAFDMSGVRGSLAEA 537
                +TA            LP    S G   +LA     VP  +P +    G   + A  
Sbjct: 1590 MAAPQTAILAPSPAPPLAPLPVLAPSPGAAPVLASSQTPVPVMAPSS--TPGTSLASASP 1647

Query: 538  VGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPA 597
            V +P P   P+ T      P     P+ A     +L     PT  G+  S     G G  
Sbjct: 1648 VPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQTLSLGTGNP 1707

Query: 598  TGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNT 657
             GP  T      P ++L     +   + P P   PT    L   P L P  P GP   +T
Sbjct: 1708 QGPFPTQTLSLTPASSLVPTPAQTLSLAPGPPLGPTQTLSLAPAPPLAPASPVGPAPAHT 1767



 Score = 64.3 bits (155), Expect = 3e-10
 Identities = 86/343 (25%), Positives = 121/343 (35%), Gaps = 51/343 (14%)

Query: 346  LADVFTAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGD 405
            L  V   P P P       P P+   +P +   S    GPP+ PA+ P     P P    
Sbjct: 1019 LGPVPVRPPPGPELSAQPTPGPVPQVLPASLMVSASPAGPPLIPASRP-----PGPVLLP 1073

Query: 406  PWRPAAPAGPSVDP-----WGGT---PAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTP 457
            P +P + + P V P       GT   P P     PTP          P    S   P T 
Sbjct: 1074 PLQPNSGSLPQVLPSPLGVLSGTSRPPTPTLSLKPTPPAPVRLSPAPPPGSSSLLKPLTV 1133

Query: 458  APAFSDPWGGSPAKPSTNGTTAAGGFDT-------EPDEFSDFDRLRTALPTSG-SSAGE 509
             P ++ P    PA  +T  TT A    T        P        ++  LP+    S G+
Sbjct: 1134 PPGYTFP----PAAATTTSTTTATATTTAVPAPTPAPQRLILSPDMQARLPSGEVVSIGQ 1189

Query: 510  LELLAGEVPARSPGA----FDMSGVRGSLAE------AVGSPPPAATPTPTPPTRKTPES 559
            L  LA    A + G+    F + G + +L        AVG P P         +      
Sbjct: 1190 LASLAQRPVANAGGSKPLTFQIQGNKLTLTGAQVRQLAVGQPRPLQRNVVHLVSAGGQHH 1249

Query: 560  FLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAP----PATLT 615
             +   A +  + ++   PGPTP         LP   P+T P+ T    P      P T+ 
Sbjct: 1250 LISQPAHVALIQAVAPTPGPTPVSV------LPSSTPSTTPAPTGLSLPLAANQVPPTMV 1303

Query: 616  LNQ------LRLSPVPPVPGAPPTYISPLGGGPGLPPMMPPGP 652
             N       +R +P   +   PP   +P     GLP ++ P P
Sbjct: 1304 NNTGVVKIVVRQAPRDGLTPVPPLAPAPRPPSSGLPAVLNPRP 1346



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 83/306 (27%), Positives = 108/306 (35%), Gaps = 59/306 (19%)

Query: 364  GPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGT 423
            G AP+  + P   P+S P  GP   P   P   P  +P S     P + + P   P   T
Sbjct: 1391 GAAPLTISSPLHVPSSLP--GPASSPMPIPNSSPLASPVSSTVSVPLSSSLPISVP---T 1445

Query: 424  PAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTP-----APAFSDPWGGSPAKPSTNGTT 478
              PA    P   P  S+   V  SGP+     TP      PA   P   +P+  S + + 
Sbjct: 1446 TLPAPASAPLTIPI-SAPLTVSASGPALLTSVTPPLAPVVPAAPGPPSLAPSGASPSASA 1504

Query: 479  AAGGFDTEPDEFSDFDRLRTAL--PTSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAE 536
               G  T P   S        L  PTS    G    +A   PA SP            A 
Sbjct: 1505 LTLGLATAPSLSSSQTPGHPLLLAPTSSHVPGLNSTVA---PACSPVLVP--------AS 1553

Query: 537  AVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGP 596
            A+ SP P+A P P P       S L P ++                    + P  P   P
Sbjct: 1554 ALASPFPSA-PNPAP----AQASLLAPASSA---------------SQALATPLAPMAAP 1593

Query: 597  ATGPSVTNPFQPAPPATLTLNQLRLSPVP---PVPGAPPTYISPLGGGPGLPPMMPPGPP 653
             T  ++  P  PAPP         L+P+P   P PGA P   S     P + P   PG  
Sbjct: 1594 QT--AILAP-SPAPP---------LAPLPVLAPSPGAAPVLASSQTPVPVMAPSSTPGTS 1641

Query: 654  APNTNP 659
              + +P
Sbjct: 1642 LASASP 1647



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 96/350 (27%), Positives = 120/350 (34%), Gaps = 77/350 (22%)

Query: 335  TGGKEESSLMDLADVFTAPAPAPTTDPWGGP---APMAAAVPTAAPTSDPWGGPPVPPA- 390
            +G    +S + L  + TAP+ + +  P G P   AP ++ VP    T  P   P + PA 
Sbjct: 1496 SGASPSASALTLG-LATAPSLSSSQTP-GHPLLLAPTSSHVPGLNSTVAPACSPVLVPAS 1553

Query: 391  --ADPW-GGPAPTPASGDPWRPAA--------PAGPSVDPWGGTPAPAAGEGPTPDP-WG 438
              A P+   P P PA      PA+        P  P   P     AP+      P P   
Sbjct: 1554 ALASPFPSAPNPAPAQASLLAPASSASQALATPLAPMAAPQTAILAPSPAPPLAPLPVLA 1613

Query: 439  SSDGGVPVSGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTE-PDEFSDFDRLR 497
             S G  PV   S     TP P          A  ST GT+ A       P         +
Sbjct: 1614 PSPGAAPVLASSQ----TPVPVM--------APSSTPGTSLASASPVPAPTPVLAPSSTQ 1661

Query: 498  TALPTSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAAT----------P 547
            T LP    S           P  SP +     +  +LA  +G   P+ T          P
Sbjct: 1662 TMLPAPVPS-----------PLPSPASTQTLALAPALAPTLGGSSPSQTLSLGTGNPQGP 1710

Query: 548  TPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQ 607
             PT     TP S L P  A     +L   PGP P G   +    P   P   P+  +P  
Sbjct: 1711 FPTQTLSLTPASSLVPTPA----QTLSLAPGP-PLGPTQTLSLAPA--PPLAPA--SPVG 1761

Query: 608  PAPPATLTL---------------NQLRLSPVPPVPGAPPTYISPLGGGP 642
            PAP  TLTL                 L LSP  PVP   P     L   P
Sbjct: 1762 PAPAHTLTLAPASSSASLLAPASVQTLTLSPA-PVPTLGPAAAQTLALAP 1810



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 71/273 (26%), Positives = 99/273 (36%), Gaps = 42/273 (15%)

Query: 346  LADVFTAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADP-WGGPAPTP--- 401
            LA     PAP P   P      + A VP+  P+        + PA  P  GG +P+    
Sbjct: 1642 LASASPVPAPTPVLAPSSTQTMLPAPVPSPLPSPASTQTLALAPALAPTLGGSSPSQTLS 1701

Query: 402  -ASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAP- 459
              +G+P  P      S+        PA+   PTP    S   G P+ GP+ +    PAP 
Sbjct: 1702 LGTGNPQGPFPTQTLSL-------TPASSLVPTPAQTLSLAPGPPL-GPTQTLSLAPAPP 1753

Query: 460  -AFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVP 518
             A + P G +PA   T    ++      P            +PT G +A +   LA    
Sbjct: 1754 LAPASPVGPAPAHTLTLAPASSSASLLAPASVQTLTLSPAPVPTLGPAAAQTLALA-PAS 1812

Query: 519  ARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPG 578
             +SP          S A ++      A P P     + P S   P       D+L  R G
Sbjct: 1813 TQSP---------ASQASSLVVSASGAAPLPVTMVSRLPVSKDEP-------DTLTLRSG 1856

Query: 579  PTPPGAKASNPFLPGGGPATGPSVTNPFQPAPP 611
            P  P + A++     GGP          QP PP
Sbjct: 1857 PPSPPSTATS----FGGPRPRR------QPPPP 1879



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 71/258 (27%), Positives = 100/258 (38%), Gaps = 36/258 (13%)

Query: 397  PAPTPASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGV--------PVSG 448
            P PTP S     P++    +  P G +   AA + P   P   ++ GV        P  G
Sbjct: 1267 PGPTPVSV---LPSSTPSTTPAPTGLSLPLAANQVP---PTMVNNTGVVKIVVRQAPRDG 1320

Query: 449  PSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAG 508
             +   P  PAP    P  G PA  +   T   G   T           R  +PT      
Sbjct: 1321 LTPVPPLAPAPR--PPSSGLPAVLNPRPTLTPGRLPTPT-----LGTARAPMPTPTLVRP 1373

Query: 509  ELELL---AGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNA 565
             L+L+   + EV A +PGA  ++ +   L      P PA++P P P    +P +    + 
Sbjct: 1374 LLKLVHSPSPEVSASAPGAAPLT-ISSPLHVPSSLPGPASSPMPIP--NSSPLASPVSST 1430

Query: 566  ALVDLDSLVSRPGPTPPGAKASNPF-LPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPV 624
              V L S +    PT   A AS P  +P   P T          + PA LT     L+PV
Sbjct: 1431 VSVPLSSSLPISVPTTLPAPASAPLTIPISAPLT-------VSASGPALLTSVTPPLAPV 1483

Query: 625  PPVPGAPPTYISPLGGGP 642
             P    PP+ ++P G  P
Sbjct: 1484 VPAAPGPPS-LAPSGASP 1500



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 42/140 (30%), Positives = 55/140 (39%), Gaps = 21/140 (15%)

Query: 522  PGAFDMSGVRGSLAEAVGS---PPPAA--TPTPTPPTRKTPESFLGPNAALVDLDSLVSR 576
            PG      +RG+ AE  G+   P  +A  T + T P R +P     P  A         R
Sbjct: 2391 PGTRVSERLRGARAETQGANHTPVISAHQTRSTTTPPRCSPARERVPRPA--------PR 2442

Query: 577  PGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYIS 636
            P PTP  A A+ P L          V+ P   + P  +T+  + + P PP P   P   S
Sbjct: 2443 PRPTPASAPAAIPAL------VPVPVSAPVPISAPNPITILPVHILPSPPPPSQIPPCSS 2496

Query: 637  PLGGGPG--LPPMMPPGPPA 654
            P    P    PP     PPA
Sbjct: 2497 PACTPPPACTPPPAHTPPPA 2516



 Score = 36.2 bits (82), Expect = 0.099
 Identities = 80/317 (25%), Positives = 99/317 (31%), Gaps = 36/317 (11%)

Query: 353  PAPAPTTDPWGGPAPMAAAVPTAAPTS------DPWGGPPVPPAADPWGGPAPTPASGDP 406
            PA AP   P   P P++A VP +AP             PP P    P   PA TP     
Sbjct: 2447 PASAPAAIPALVPVPVSAPVPISAPNPITILPVHILPSPPPPSQIPPCSSPACTPPPACT 2506

Query: 407  WRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVS-GPSASDPWTPAPAFSDPW 465
              P A   P       TP+     GP   P  +S   +P+   P A      A A + P 
Sbjct: 2507 -PPPAHTPPPAQTCLVTPSSPLLLGPPSVPISASVTNLPLGLRPEAE---LCAQALASPE 2562

Query: 466  G---GSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSP 522
                 S A   T+  +     D  P            L  +  SA  L L AG +P    
Sbjct: 2563 SLELASVASSETSSLSLVPPKDLLPVAVEILPVSEKNLSLT-PSAPSLTLEAGSIP---- 2617

Query: 523  GAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPP 582
                     G   EA  S     T T  P   + P      N   +   +    P   P 
Sbjct: 2618 --------NGQEQEAPDS-AEGTTLTVLPEGEELPLCVSESNGLELPPSAASDEPLQEPL 2668

Query: 583  GA-KASNPFLPGGGPATGPSVTNPFQPAP-PATLTLNQLRLSPVPPVPGAPP-----TYI 635
             A + S        P + P        A   A  T +    SP  P P  PP       +
Sbjct: 2669 EADRTSEELTEAKTPTSSPEKPQELVTAEVAAPSTSSSATSSPEGPSPARPPRRRTSADV 2728

Query: 636  SPLGGGPGLPPMMPPGP 652
               G G G P   PPGP
Sbjct: 2729 EIRGQGTGRPG-QPPGP 2744



 Score = 35.8 bits (81), Expect = 0.13
 Identities = 41/146 (28%), Positives = 55/146 (37%), Gaps = 24/146 (16%)

Query: 531  RGSLAEAVGSPPPAATPTPT---------PPTRKTPESFLGPNAALVDLDSLVSRPGPTP 581
            R  L E   +P P   P P          P  ++   + +  N     L  +  RP   P
Sbjct: 971  RRVLLEVATAPDPPPRPKPVKMKVNRMLQPVPKQEGRTVVVVNNPRAPLGPVPVRP---P 1027

Query: 582  PGAKASNPFLPGGGPATGP-----SVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYI- 635
            PG + S    PG  P   P     S +    P  PA+     + L P+ P  G+ P  + 
Sbjct: 1028 PGPELSAQPTPGPVPQVLPASLMVSASPAGPPLIPASRPPGPVLLPPLQPNSGSLPQVLP 1087

Query: 636  SPLG--GGPGLPPM----MPPGPPAP 655
            SPLG   G   PP     + P PPAP
Sbjct: 1088 SPLGVLSGTSRPPTPTLSLKPTPPAP 1113


>gi|116256453 nuclear receptor co-repressor 2 isoform 1 [Homo sapiens]
          Length = 2524

 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 125/510 (24%), Positives = 178/510 (34%), Gaps = 94/510 (18%)

Query: 137  EATSNDPWGPSSSLMSEIADLTYNVVA--FSEIMSMIWKRLNDHGKNWRHVYKAMTLMEY 194
            EA S +   P  S  +E+A +  N  +    E M    K L +HG+NW  + + +     
Sbjct: 589  EANSEEAITPQQS--AELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMV----- 641

Query: 195  LIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVREKAKQLVALLRDEDRLREE 254
                GS+ VSQ CK N Y       F Y  R   D+              +  + +L+ E
Sbjct: 642  ----GSKTVSQ-CK-NFY-------FNYKKRQNLDE--------------ILQQHKLKME 674

Query: 255  RAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQSSGEEELQLQLALAMSKEEADQEE 314
            +    + K+K A  A +  AA     PP  E    ++SG                 ++EE
Sbjct: 675  KERNARRKKKKAPAAASEEAAF----PPVVEDEEMEASGVS--------------GNEEE 716

Query: 315  RIRRGDDLRLQMAIEESKRETGGKEESSLMDLADVFTAPAP---APTTDPWGGPAPMAAA 371
             +   + L      E  + E  G   +++ + +D  + P+P   A       GP P    
Sbjct: 717  MVEEAEALHAS-GNEVPRGECSGP--ATVNNSSDTESIPSPHTEAAKDTGQNGPKP---- 769

Query: 372  VPTAAPTSDPWGGPPVPPAADPWGGPAPTPAS---GDPWRPAAPAGPSVDPWGGTPAPAA 428
             P       P  GPP PP  D      PTPAS   G P  P AP  PS  P    P    
Sbjct: 770  -PATLGADGPPPGPPTPPPEDIPAPTEPTPASEATGAPTPPPAPPSPSAPP-PVVPKEEK 827

Query: 429  GEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPD 488
             E     P    + G     P+A +         +P      + +  G   A G D E  
Sbjct: 828  EEETAAAP--PVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEG--PAKGKDAEAA 883

Query: 489  EFSDFDRLRTALPTSGSSAGELELLAG----EVPARSPGAFDMSGVRGSLAEAVGSPPPA 544
            E +    L+      GS        +G       + +  A ++    G     + SP P+
Sbjct: 884  EATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPS 943

Query: 545  -ATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPP-GAKASNPFLPGGGPATGPSV 602
              TPT  P    +P+  L       DL  L  R    PP   K   P      P    + 
Sbjct: 944  LLTPTGDPRANASPQKPL-------DLKQLKQRAAAIPPIVTKVHEP------PREDAAP 990

Query: 603  TNPFQPAPPATLTLNQLRLSPVPPVPGAPP 632
            T P  PAPP    L     S  P  PG+ P
Sbjct: 991  TKPAPPAPPPPQNLQP--ESDAPQQPGSSP 1018



 Score = 32.3 bits (72), Expect = 1.4
 Identities = 82/357 (22%), Positives = 113/357 (31%), Gaps = 68/357 (19%)

Query: 262  KEKLAQTATASSAAVGSGPPPEAEQAWPQSSGEEELQLQLALAMSKEEADQEERIRRGDD 321
            +EK  +TA A     G    P A +     +G+ E  ++       EE   + +     +
Sbjct: 825  EEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAE 884

Query: 322  LRLQMAIEESKRETGG-------------KEESSLMDLADV-----------FTAPAPA- 356
               + A++  K+E G                +SS    AD              +P P+ 
Sbjct: 885  ATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSL 944

Query: 357  --PTTDPWGGPAPM-----------AAAVPT------------AAPTSDPWGGPPVPPAA 391
              PT DP    +P            AAA+P             AAPT      PP P   
Sbjct: 945  LTPTGDPRANASPQKPLDLKQLKQRAAAIPPIVTKVHEPPREDAAPTKPAPPAPPPPQNL 1004

Query: 392  DPWGGPAPTPAS---GDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSG 448
             P       P S   G    PA PA    +     PA AA     P        G+P   
Sbjct: 1005 QPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFPV 1064

Query: 449  PS----ASDPWTPAP-AFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTS 503
            P      + P  P P AFS    G P     + T  A      P   S+        P  
Sbjct: 1065 PPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDT--ARPVLPRPPTISN-------PPPL 1115

Query: 504  GSSAGELELLAGEVPARSPG-AFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPES 559
             SSA    +L  ++ A S G +  +       A+A   P     P P  P +  P S
Sbjct: 1116 ISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFS 1172



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 20/60 (33%), Positives = 26/60 (43%), Gaps = 5/60 (8%)

Query: 578 GPTPPGAKASNPFLPGGGPATGP--SVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYI 635
           GP PP    ++   P  GP T P   +  P +P P +  T       P PP P APP  +
Sbjct: 766 GPKPPATLGADG--PPPGPPTPPPEDIPAPTEPTPASEAT-GAPTPPPAPPSPSAPPPVV 822



 Score = 31.6 bits (70), Expect = 2.4
 Identities = 20/54 (37%), Positives = 24/54 (44%), Gaps = 3/54 (5%)

Query: 608 PAPPATLTLNQLRLSPVPPVPG--APPTYISPLGGGPGLPPMMPPGPPAPNTNP 659
           P PPATL  +     P  P P     PT  +P     G  P  PP PP+P+  P
Sbjct: 767 PKPPATLGADGPPPGPPTPPPEDIPAPTEPTPASEATG-APTPPPAPPSPSAPP 819



 Score = 31.2 bits (69), Expect = 3.2
 Identities = 45/192 (23%), Positives = 66/192 (34%), Gaps = 30/192 (15%)

Query: 449  PSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAG 508
            P+A  P++   + S    G P   +   TT++   + + D   D DR R     + ++  
Sbjct: 1769 PTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTSTTTV 1828

Query: 509  ELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALV 568
            E        P   PG    SG  GS     GS     +  P   +     S + P     
Sbjct: 1829 E------HAPIWRPGTEQSSGSSGSSGGGGGS-----SSRPASHSHAHQHSPISPRTQ-- 1875

Query: 569  DLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVP 628
              D+L  RP      +   N  + G        +    +P+ P  L       SPV P  
Sbjct: 1876 --DALQQRP------SVLHNTGMKG--------IITAVEPSTPTVLRSTSTS-SPVRPAA 1918

Query: 629  GAPPTYISPLGG 640
              PP    PLGG
Sbjct: 1919 TFPPATHCPLGG 1930


>gi|149773456 hypothetical protein LOC643314 [Homo sapiens]
          Length = 1427

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 90/320 (28%), Positives = 112/320 (35%), Gaps = 53/320 (16%)

Query: 354  APAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPAA-- 411
            +PA    P   P   AAAVPT    + P    P P   +P    A  P   +P  PAA  
Sbjct: 1028 SPAAAVPPPEEPTSPAAAVPTPEEPTSPAAAVPTP--EEPTSPAAAVPTPEEPTSPAAAV 1085

Query: 412  -----PAGPSVD-PWGGTPAPAAGEGPTPDPWGSSDGGVPV----SGPSASDPWTPAPAF 461
                 P  P+   P    P   A   PTP+   S    VP     + P+A+ P    PAF
Sbjct: 1086 PTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPASPAAAVPTPEEPASPAAAVPTPEEPAF 1145

Query: 462  SDPWGGSP--------AKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELL 513
              P   +P        A P+   + +       P E + F  +   L    S A  +   
Sbjct: 1146 PAPAVPTPEESASAAVAVPTPEESASPAAAVPTPAESASFAAVVATLEEPTSPAASVPTP 1205

Query: 514  AGEVPA----RSPGA-FDMSGVRGSLAEAVGSP-----PPAATPTPTPPTRK-----TPE 558
            A  V       SP A    S    SLA AV +P     P AA PT   PT       TPE
Sbjct: 1206 AAMVATLEEFTSPAASVPTSEEPASLAAAVSNPEEPTSPAAAVPTLEEPTSSAAAVLTPE 1265

Query: 559  SFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQ 618
                P A      S+ +   P  P A  SN   P    A  P+   P   A PA      
Sbjct: 1266 ELSSPAA------SVPTPEEPASPAAAVSNLEEPASPAAAVPT---PEVAAIPAASV--- 1313

Query: 619  LRLSPVPPVPGAPPTYISPL 638
                P P VP  P   + P+
Sbjct: 1314 ----PTPEVPAIPAAAVPPM 1329



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 94/325 (28%), Positives = 120/325 (36%), Gaps = 52/325 (16%)

Query: 354  APAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPAA-- 411
            A  PT +    P   AAAVPT    + P     VPP  +P    A  P   +P  PAA  
Sbjct: 1005 AAVPTPEE---PTSPAAAVPTPEEPTSP--AAAVPPPEEPTSPAAAVPTPEEPTSPAAAV 1059

Query: 412  -----PAGPSVD-PWGGTPAPAAGEGPTPDPWGSSDGGVPV----SGPSASDPWTP---- 457
                 P  P+   P    P   A   PTP+   S    VP     + P+A+ P TP    
Sbjct: 1060 PTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVPTPEEPTSPAAAVP-TPEEPA 1118

Query: 458  APAFSDPWGGSPAKPSTNGTT------AAGGFDTEPDEFSDFDRLRTALPTSGSSAGELE 511
            +PA + P    PA P+    T       A    T  +  S       A+PT   SA    
Sbjct: 1119 SPAAAVPTPEEPASPAAAVPTPEEPAFPAPAVPTPEESAS----AAVAVPTPEESASP-- 1172

Query: 512  LLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLD 571
              A  VP  +  A   + V  +L E   + P A+ PTP      T E F  P A      
Sbjct: 1173 --AAAVPTPAESA-SFAAVVATLEEP--TSPAASVPTPAAMV-ATLEEFTSPAA------ 1220

Query: 572  SLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLS----PVPPV 627
            S+ +   P    A  SNP  P    A  P++  P   A  A LT  +L       P P  
Sbjct: 1221 SVPTSEEPASLAAAVSNPEEPTSPAAAVPTLEEPTSSA-AAVLTPEELSSPAASVPTPEE 1279

Query: 628  PGAPPTYISPLGGGPGLPPMMPPGP 652
            P +P   +S L   P  P    P P
Sbjct: 1280 PASPAAAVSNL-EEPASPAAAVPTP 1303


>gi|122937267 lemur tyrosine kinase 3 [Homo sapiens]
          Length = 1489

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 99/328 (30%), Positives = 116/328 (35%), Gaps = 76/328 (23%)

Query: 360 DPWGGPAPMAAAVPTAAP--TSDPWGGPPVPPAADPWGGPAPTPASGD----PWRPAAP- 412
           DP G PAP A   P+  P   S+ W  P + PA  P+  PA + ASG      W P    
Sbjct: 590 DP-GVPAPQAPQAPSEVPQLVSETWASP-LFPAPRPF--PAQSSASGSFLLSGWDPEGRG 645

Query: 413 AGPSVDPWGGTPAPAAGEGPTPDPW---------GSSDGGVPVS---GPSASDPWTPAPA 460
           AG ++    G PA   GE  T  PW         GSS G    S   GPS   P  P P 
Sbjct: 646 AGETL---AGDPAEVLGERGTA-PWVEEEEEEEEGSSPGEDSSSLGGGPSRRGP-LPCPL 700

Query: 461 FSDPWGGSPAKPSTNGTTAAG-------GFDTEPDEFSDFDRLRTALPTSGSSAGELELL 513
            S   G     P   G   AG       G    P++ S     R          G L  L
Sbjct: 701 CSRE-GACSCLPLERGDAVAGWGGHPALGCPHPPEDDSSLRAER----------GSLADL 749

Query: 514 AGEVPARSPGAF--DMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLD 571
               PA +P  F   + G         G PP    P P P     P +   P +A+    
Sbjct: 750 PMAPPASAPPEFLDPLMGAAAPQYPGRGPPPAPPPPPPPPRAPADPAASPDPPSAVASPG 809

Query: 572 SLVSRPGPTP--PGAKASNPF-----LPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPV 624
           S +S PGP P   G +   PF      PGGG A    V  P              R  P 
Sbjct: 810 SGLSSPGPKPGDSGYETETPFSPEGAFPGGGAAEEEGVPRP--------------RAPPE 855

Query: 625 PPVPGAPPTYISPLGGGPGLPPMMPPGP 652
           PP PGAP          P   P+  PGP
Sbjct: 856 PPDPGAPRP-------PPDPGPLPLPGP 876



 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 99/381 (25%), Positives = 127/381 (33%), Gaps = 120/381 (31%)

Query: 353 PAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADP------------------W 394
           P P P   P+  P P A + P     S P+      P ADP                  W
Sbjct: 451 PPPPPRDGPFPWPWPPAHSAPRPGTLSSPFPLLDGFPGADPDDVLTVTESSRGLNLECLW 510

Query: 395 -----------GGPAPTPASGDPWRPAAPAGP--------SVDPWGGTPAPAAGE----- 430
                      G PA  PAS  P   A P+ P        SV P     +P+        
Sbjct: 511 EKARRGAGRGGGAPAWQPASAPPAPHANPSNPFYEALSTPSVLPVISARSPSVSSEYYIR 570

Query: 431 ----GPTPDP-----WGSSDGGVPV----SGPS-----ASDPWTPAPAFSDPWGGSPAKP 472
               G  P+P     W   D GVP       PS      S+ W  +P F  P    PA+ 
Sbjct: 571 LEEHGSPPEPLFPNDWDPLDPGVPAPQAPQAPSEVPQLVSETWA-SPLFPAP-RPFPAQS 628

Query: 473 STNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGAFDMSGVRG 532
           S +G+    G+D E                 G  AGE   LAG+ PA      ++ G RG
Sbjct: 629 SASGSFLLSGWDPE-----------------GRGAGET--LAGD-PA------EVLGERG 662

Query: 533 SLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTP------PGAKA 586
           +               P     +  E    P      L    SR GP P       GA +
Sbjct: 663 T--------------APWVEEEEEEEEGSSPGEDSSSLGGGPSRRGPLPCPLCSREGACS 708

Query: 587 SNPFLPG---GGPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVP--GAPPTYISPLGG- 640
             P   G    G    P++  P  P   ++L   +  L+ +P  P   APP ++ PL G 
Sbjct: 709 CLPLERGDAVAGWGGHPALGCPHPPEDDSSLRAERGSLADLPMAPPASAPPEFLDPLMGA 768

Query: 641 ------GPGLPPMMPPGPPAP 655
                 G G PP  PP PP P
Sbjct: 769 AAPQYPGRGPPPAPPPPPPPP 789



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 76/283 (26%), Positives = 92/283 (32%), Gaps = 54/283 (19%)

Query: 388  PPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGTPAPAAG--EGPTPDPWGSSDGGVP 445
            PP   PW  P P   + + W PA        P  G PAP       P P    SS  G  
Sbjct: 1047 PPETGPWRAPGPWEKTPESWGPA--------PTIGEPAPETSLERAPAPSAVVSSRNG-- 1096

Query: 446  VSGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGS 505
              G +A  P  PAP               NGT   G     P E     R   A      
Sbjct: 1097 --GETAPGPLGPAP--------------KNGTLEPGTERRAP-ETGGAPRAPGAGRLDLG 1139

Query: 506  SAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATP----------TPTPPTRK 555
            S G   +  G  P   PG+  +    G +      PPP   P           P PP  +
Sbjct: 1140 SGGRAPVGTGTAPGGGPGS-GVDAKAGWVDNTRPQPPPPPLPPPPEAQPRRLEPAPPRAR 1198

Query: 556  ---TPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQ---PA 609
                PE   G   +    D+ +S  G  PP  +   P +P      GP   N  Q     
Sbjct: 1199 PEVAPEGEPGAPDSRAGGDTALSGDG-DPPKPERKGPEMPRLFLDLGPPQGNSEQIKARL 1257

Query: 610  PPATLTLNQLRLSPVP-PVPGAPPTYISPLG------GGPGLP 645
               +L L  L L+P P P P  PP   +  G      GG G P
Sbjct: 1258 SRLSLALPPLTLTPFPGPGPRRPPWEGADAGAAGGEAGGAGAP 1300



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 93/391 (23%), Positives = 118/391 (30%), Gaps = 87/391 (22%)

Query: 339  EESSLMDLADVFTAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPP--------- 389
            E  SL DL     A AP    DP  G          AA    P  GPP  P         
Sbjct: 742  ERGSLADLPMAPPASAPPEFLDPLMG----------AAAPQYPGRGPPPAPPPPPPPPRA 791

Query: 390  AADPWGGPAPTPASGDPWRPAAPAGPSVDPWG-GTPAPAAGEGPTPDPWGSSDGGV--PV 446
             ADP   P P  A   P    +  GP     G  T  P + EG  P    + + GV  P 
Sbjct: 792  PADPAASPDPPSAVASPGSGLSSPGPKPGDSGYETETPFSPEGAFPGGGAAEEEGVPRPR 851

Query: 447  SGPSASDPWTPAPAFSD---PWGGSPAKPS------------------------TNGTTA 479
            + P   DP  P P       P  G   KP+                          G TA
Sbjct: 852  APPEPPDPGAPRPPPDPGPLPLPGPREKPTFVVQVSTEQLLMSLREDVTRNLLGEKGATA 911

Query: 480  -------AGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPA------RSPGAFD 526
                   AG      ++    +R  T L  +G  A  L L    V        R+PG  +
Sbjct: 912  RETGPRKAGRGPGNREKVPGLNRDPTVL-GNGKQAPSLSLPVNGVTVLENGDQRAPGIEE 970

Query: 527  MSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKA 586
             +   G+L               TPP R+      G   +    + ++   G TPP  K+
Sbjct: 971  KAAENGALGSPEREEKVLENGELTPPRREEKALENGELRSPEAGEKVLVNGGLTPP--KS 1028

Query: 587  SNPFLPGGG----------PATGP--------SVTNPFQPAPPATLTLNQLRLSPVPPVP 628
             +     GG          P TGP             + PAP       +  L   P   
Sbjct: 1029 EDKVSENGGLRFPRNTERPPETGPWRAPGPWEKTPESWGPAPTIGEPAPETSLERAP--- 1085

Query: 629  GAPPTYISPLGGGPGLPPMMPPGPPAPNTNP 659
             AP   +S   GG   P  + P P      P
Sbjct: 1086 -APSAVVSSRNGGETAPGPLGPAPKNGTLEP 1115



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 75/335 (22%), Positives = 92/335 (27%), Gaps = 68/335 (20%)

Query: 353  PAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPAAP 412
            P P     P   P  +  A P A P   P G P  P +    GG       GDP +P   
Sbjct: 1175 PPPPLPPPPEAQPRRLEPAPPRARPEVAPEGEPGAPDSRA--GGDTALSGDGDPPKPERK 1232

Query: 413  AGPSVD--------PWGG------------------TPAPAAGEGPTPDPWGSSDGGVPV 446
             GP +         P G                   T  P  G GP   PW  +D G   
Sbjct: 1233 -GPEMPRLFLDLGPPQGNSEQIKARLSRLSLALPPLTLTPFPGPGPRRPPWEGADAGA-- 1289

Query: 447  SGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSS 506
            +G  A     P PA  D                  G D + DE  D +            
Sbjct: 1290 AGGEAGGAGAPGPAEED------------------GEDEDEDEEEDEEAAAPGAAAGPRG 1331

Query: 507  AGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPT------------- 553
             G        V   S  A     +RG L    G+  P  +                    
Sbjct: 1332 PGRARAAPVPVVVSSADADAARPLRGLLKSPRGADEPEDSELERKRKMVSFHGDVTVYLF 1391

Query: 554  -RKTPESFLGPNAALV-DLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVT----NPFQ 607
             ++TP + L   A    D D       PTPP         P      G S       P  
Sbjct: 1392 DQETPTNELSVQAPPEGDTDPSTPPAPPTPPHPATPGDGFPSNDSGFGGSFEWAEDFPLL 1451

Query: 608  PAPPATLTLNQLRLSPVPPVPGAPPTYISPLGGGP 642
            P P   L  ++  +SP    PG P         GP
Sbjct: 1452 PPPGPPLCFSRFSVSPALETPGPPARAPDARPAGP 1486



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 95/402 (23%), Positives = 114/402 (28%), Gaps = 97/402 (24%)

Query: 324  LQMAIEESKRETGGKEES---SLMDLADVFTAPAPAPTTDPWGGPAP----MAAAVPTAA 376
            L+   E    ETGG   +     +DL     AP    T  P GGP       A  V    
Sbjct: 1113 LEPGTERRAPETGGAPRAPGAGRLDLGSGGRAPVGTGTA-PGGGPGSGVDAKAGWVDNTR 1171

Query: 377  PTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPD- 435
            P   P   PP P A      PAP  A  +      P  P     G T     G+ P P+ 
Sbjct: 1172 PQPPPPPLPPPPEAQPRRLEPAPPRARPEVAPEGEPGAPDSRAGGDTALSGDGDPPKPER 1231

Query: 436  --------------PWGSSD----------------GGVPVSGPS-ASDPWTPAPAFSDP 464
                          P G+S+                   P  GP     PW  A A +  
Sbjct: 1232 KGPEMPRLFLDLGPPQGNSEQIKARLSRLSLALPPLTLTPFPGPGPRRPPWEGADAGAA- 1290

Query: 465  WGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGA 524
             GG        G     G D + DE  D +             G        V   S  A
Sbjct: 1291 -GGEAGGAGAPGPAEEDGEDEDEDEEEDEEAAAPGAAAGPRGPGRARAAPVPVVVSSADA 1349

Query: 525  FDMSGVRGSLAEAVGSPPP------------------------AATPTPTPPTRKTPESF 560
                 +RG L    G+  P                          TPT     +  PE  
Sbjct: 1350 DAARPLRGLLKSPRGADEPEDSELERKRKMVSFHGDVTVYLFDQETPTNELSVQAPPEG- 1408

Query: 561  LGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGG-PATGPSVTNPFQPAPPATLTLNQL 619
                    D D       PTPP     +P  PG G P+        F+ A          
Sbjct: 1409 --------DTDPSTPPAPPTPP-----HPATPGDGFPSNDSGFGGSFEWAED-------- 1447

Query: 620  RLSPVPPVPGAPPTYISPLGGGPGLPPMMPPGPP--APNTNP 659
               P+ P PG PP   S     P L     PGPP  AP+  P
Sbjct: 1448 --FPLLPPPG-PPLCFSRFSVSPALE---TPGPPARAPDARP 1483


>gi|21389357 MAPK-interacting and spindle-stabilizing protein [Homo
           sapiens]
          Length = 245

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 91/307 (29%), Positives = 114/307 (37%), Gaps = 77/307 (25%)

Query: 341 SSLMDLADVFTAPAPAPT-----TDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWG 395
           S    LAD     +PA T     T P G P       P   P S+PW  P  P +     
Sbjct: 2   SDEFSLADALPEHSPAKTSAVSNTKP-GQP-------PQGWPGSNPWNNPSAPSSVPSGL 53

Query: 396 GPAPTPASGDPWRPAAPAG--PSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASD 453
            P+ TP++  P+ PA P G  PSV P G  P P       P P+       P SGPS   
Sbjct: 54  PPSATPSTV-PFGPA-PTGMYPSVPPTGPPPGP-------PAPF-------PPSGPSCPP 97

Query: 454 PWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELL 513
           P  P PA           P+  G    G + T    F +  R   A PT  ++AG L   
Sbjct: 98  PGGPYPA-----------PTVPGPGPTGPYPTPNMPFPELPRPYGA-PTDPAAAGPLG-- 143

Query: 514 AGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSL 573
               P  S  +   +   G        P P+  P P PP  + P +   P          
Sbjct: 144 ----PWGSMSSGPWAPGMGGQYPTPNMPYPSPGPYPAPPPPQAPGA--APPVPW------ 191

Query: 574 VSRPGPTPPGA---KASNPFLPGGGPATG--PSVTNPFQ-PAPPATLTLNQLRLSPVPPV 627
               G  PPGA    A  P   G  P  G  P+ +NPFQ P+ P          S  PP+
Sbjct: 192 ----GTVPPGAWGPPAPYPAPTGSYPTPGLYPTPSNPFQVPSGP----------SGAPPM 237

Query: 628 PGAPPTY 634
           PG P +Y
Sbjct: 238 PGGPHSY 244



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 51/188 (27%), Positives = 66/188 (35%), Gaps = 31/188 (16%)

Query: 488 DEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATP 547
           DEFS  D L    P   S+    +   G+ P   PG+   +      +   G PP +ATP
Sbjct: 3   DEFSLADALPEHSPAKTSAVSNTK--PGQPPQGWPGSNPWNNPSAPSSVPSGLPP-SATP 59

Query: 548 TPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQ 607
           +  P           P      +      PGP  P   +     P GGP   P+V  P  
Sbjct: 60  STVPFGP-------APTGMYPSVPPTGPPPGPPAPFPPSGPSCPPPGGPYPAPTVPGPGP 112

Query: 608 PAPPATLTLNQLRLSPVPPVP---GAP--PTYISPLG------GGPGLPPM----MPPGP 652
             P  T  +      P P +P   GAP  P    PLG       GP  P M      P  
Sbjct: 113 TGPYPTPNM------PFPELPRPYGAPTDPAAAGPLGPWGSMSSGPWAPGMGGQYPTPNM 166

Query: 653 PAPNTNPF 660
           P P+  P+
Sbjct: 167 PYPSPGPY 174



 Score = 40.0 bits (92), Expect = 0.007
 Identities = 41/135 (30%), Positives = 49/135 (36%), Gaps = 23/135 (17%)

Query: 542 PPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPF----LPGGGPA 597
           PP   P P PP+  +     GP  A       V  PGPT P    + PF     P G P 
Sbjct: 80  PPPGPPAPFPPSGPSCPPPGGPYPA-----PTVPGPGPTGPYPTPNMPFPELPRPYGAP- 133

Query: 598 TGPSVTNPFQP-----APPATLTLNQLRLSPVPPVPGAPPTYISPLGGGPGLPP-----M 647
           T P+   P  P     + P    +     +P  P P   P    P    PG  P      
Sbjct: 134 TDPAAAGPLGPWGSMSSGPWAPGMGGQYPTPNMPYPSPGPYPAPPPPQAPGAAPPVPWGT 193

Query: 648 MPP---GPPAPNTNP 659
           +PP   GPPAP   P
Sbjct: 194 VPPGAWGPPAPYPAP 208


>gi|42544130 splicing factor 1 isoform 1 [Homo sapiens]
          Length = 639

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 97/356 (27%), Positives = 122/356 (34%), Gaps = 69/356 (19%)

Query: 338 KEESSLMDLADVFTAPAPAPTTDPWGGPA--PMAAAVPTAAPTSDPWGGPPVPPAADPWG 395
           KE  SLM  A++  AP PA +     GPA  P+A+A   AAP ++P      PP+     
Sbjct: 311 KEYLSLM--AELGEAPVPA-SVGSTSGPATTPLASAPRPAAPANNP-----PPPSL---- 358

Query: 396 GPAPTPASGDPWRPAAPAG--PSVDPWGGTPA-PAAGEGPTPDPWGSSDGGVPVSGPSAS 452
               T  S  PW  + P+   P     GG P  P  G    P P  S  GG     P   
Sbjct: 359 --MSTTQSRPPWMNSGPSESRPYHGMHGGGPGGPGGGPHSFPHPLPSLTGGHG-GHPMQH 415

Query: 453 DPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELEL 512
           +P  P P    PW   P  P   G    G     P      D+   + P  GS    L  
Sbjct: 416 NPNGPPP----PWMQPPPPPMNQGPHPPGHHGPPP-----MDQYLGSTPV-GSGVYRLHQ 465

Query: 513 LAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAAT-------------PTPTPPTRKTPES 559
             G +P    G         S     G PPP  +             P P PP+     S
Sbjct: 466 GKGMMPPPPMGMMPPPPPPPS-----GQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASS 520

Query: 560 FLGPNAALVDLDSLVSRPGPTPP------------------GAKASNPFLPGGGPATGPS 601
              P        +  +  G  PP                  G     P  PG  P   P 
Sbjct: 521 TPLPWQQNTTTTTTSAGTGSIPPWQQQQAAAAASPGAPQMQGNPTMVPLPPGVQPPLPPG 580

Query: 602 VTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLG-GGPGLPPM-MPPGPPAP 655
              P  P PP +  +      P PP P  P  +++ +G G  G+PP  MPP PP P
Sbjct: 581 APPPPPPPPPGSAGM-MYAPPPPPPPPMDPSNFVTMMGMGVAGMPPFGMPPAPPPP 635



 Score = 31.6 bits (70), Expect = 2.4
 Identities = 28/93 (30%), Positives = 31/93 (33%), Gaps = 13/93 (13%)

Query: 352 APAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPP-----AADPWGGPAPTPASGDP 406
           A A +P      G   M    P   P   P   PP PP     A   +  P P P   DP
Sbjct: 550 AAAASPGAPQMQGNPTMVPLPPGVQPPLPPGAPPPPPPPPPGSAGMMYAPPPPPPPPMDP 609

Query: 407 WRPAAPAGPSV---DPWGGTPAPAAGEGPTPDP 436
                  G  V    P+G  PAP     P P P
Sbjct: 610 SNFVTMMGMGVAGMPPFGMPPAP-----PPPPP 637


>gi|116256445 nuclear receptor co-repressor 2 isoform 2 [Homo sapiens]
          Length = 2462

 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 142/578 (24%), Positives = 201/578 (34%), Gaps = 119/578 (20%)

Query: 137  EATSNDPWGPSSSLMSEIADLTYNVVA--FSEIMSMIWKRLNDHGKNWRHVYKAMTLMEY 194
            EA S +   P  S  +E+A +  N  +    E M    K L +HG+NW  + + +     
Sbjct: 589  EANSEEAITPQQS--AELASMELNESSRWTEEEMETAKKGLLEHGRNWSAIARMV----- 641

Query: 195  LIKTGSERVSQQCKENMYAVQTLKDFQYVDRDGKDQGVNVREKAKQLVALLRDEDRLREE 254
                GS+ VSQ CK N Y       F Y  R   D+              +  + +L+ E
Sbjct: 642  ----GSKTVSQ-CK-NFY-------FNYKKRQNLDE--------------ILQQHKLKME 674

Query: 255  RAHALKTKEKLAQTATASSAAVGSGPPPEAEQAWPQS--SGEEELQLQLALAMSKEEADQ 312
            +    + K+K A  A +  AA    PP   ++    S  SG EE  ++ A A     +D 
Sbjct: 675  KERNARRKKKKAPAAASEEAAF---PPVVEDEEMEASGVSGNEEEMVEEAEATVNNSSDT 731

Query: 313  EERIRRGDDLRLQMAIEESKRETGGKEESSLMDLADVFTAPAPAPTTDPWGGPAPMAAAV 372
            E          +     E+ ++TG         L      P P PT  P   PAP     
Sbjct: 732  ES---------IPSPHTEAAKDTGQNGPKPPATLGADGPPPGP-PTPPPEDIPAPTE--- 778

Query: 373  PTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGTPAPAAGE-- 430
            PT  P S+  G P  PPA      P P     +     A A P V+       PAA E  
Sbjct: 779  PT--PASEATGAPTPPPAPPSPSAPPPVVPKEEKEEETA-AAPPVEEGEEQKPPAAEELA 835

Query: 431  ---GPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSD------------------PWGGSP 469
               G   +P  S        GP+       A A ++                     G+P
Sbjct: 836  VDTGKAEEPVKSECTEEAEEGPAKGKDAEAAEATAEGALKAEKKEGGSGRATTAKSSGAP 895

Query: 470  AKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGE----------LELLAGEVPA 519
                ++ T +A   D    E  D +RL +  P+  +  G+          L+L   +  A
Sbjct: 896  QDSDSSATCSADEVDEA--EGGDKNRLLSPRPSLLTPTGDPRANASPQKPLDLKQLKQRA 953

Query: 520  RSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGP 579
             +     ++ V     E   +P   A P P PP    PES               S   P
Sbjct: 954  AAIPPIQVTKVHEPPREDA-APTKPAPPAPPPPQNLQPESDAPQQPGSSPRGKSRS---P 1009

Query: 580  TPPGAK-ASNPF-----------LPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPPV 627
             PP  K A  P            LPG  P     +  PF P PP  +    ++ SP  P 
Sbjct: 1010 APPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGL--PF-PVPPREV----IKASPHAPD 1062

Query: 628  PGA----PPTYISPLGGGPGLPPMMPPGPPAPNTNPFL 661
            P A    PP +  PLG      P++P  P   N  P +
Sbjct: 1063 PSAFSYAPPGHPLPLGLHDTARPVLPRPPTISNPPPLI 1100



 Score = 32.0 bits (71), Expect = 1.9
 Identities = 82/358 (22%), Positives = 113/358 (31%), Gaps = 69/358 (19%)

Query: 262  KEKLAQTATASSAAVGSGPPPEAEQAWPQSSGEEELQLQLALAMSKEEADQEERIRRGDD 321
            +EK  +TA A     G    P A +     +G+ E  ++       EE   + +     +
Sbjct: 808  EEKEEETAAAPPVEEGEEQKPPAAEELAVDTGKAEEPVKSECTEEAEEGPAKGKDAEAAE 867

Query: 322  LRLQMAIEESKRETGG-------------KEESSLMDLADV-----------FTAPAPA- 356
               + A++  K+E G                +SS    AD              +P P+ 
Sbjct: 868  ATAEGALKAEKKEGGSGRATTAKSSGAPQDSDSSATCSADEVDEAEGGDKNRLLSPRPSL 927

Query: 357  --PTTDPWGGPAPM-----------AAAVPT-------------AAPTSDPWGGPPVPPA 390
              PT DP    +P            AAA+P              AAPT      PP P  
Sbjct: 928  LTPTGDPRANASPQKPLDLKQLKQRAAAIPPIQVTKVHEPPREDAAPTKPAPPAPPPPQN 987

Query: 391  ADPWGGPAPTPAS---GDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVS 447
              P       P S   G    PA PA    +     PA AA     P        G+P  
Sbjct: 988  LQPESDAPQQPGSSPRGKSRSPAPPADKEAEKPVFFPAFAAEAQKLPGDPPCWTSGLPFP 1047

Query: 448  GPS----ASDPWTPAP-AFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPT 502
             P      + P  P P AFS    G P     + T  A      P   S+        P 
Sbjct: 1048 VPPREVIKASPHAPDPSAFSYAPPGHPLPLGLHDT--ARPVLPRPPTISN-------PPP 1098

Query: 503  SGSSAGELELLAGEVPARSPG-AFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPES 559
              SSA    +L  ++ A S G +  +       A+A   P     P P  P +  P S
Sbjct: 1099 LISSAKHPSVLERQIGAISQGMSVQLHVPYSEHAKAPVGPVTMGLPLPMDPKKLAPFS 1156



 Score = 31.2 bits (69), Expect = 3.2
 Identities = 45/192 (23%), Positives = 66/192 (34%), Gaps = 30/192 (15%)

Query: 449  PSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAG 508
            P+A  P++   + S    G P   +   TT++   + + D   D DR R     + ++  
Sbjct: 1753 PTAPQPFSSRHSSSPLSPGGPTHLTKPTTTSSSERERDRDRERDRDREREKSILTSTTTV 1812

Query: 509  ELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALV 568
            E        P   PG    SG  GS     GS     +  P   +     S + P     
Sbjct: 1813 E------HAPIWRPGTEQSSGSSGSSGGGGGS-----SSRPASHSHAHQHSPISPRTQ-- 1859

Query: 569  DLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVP 628
              D+L  RP      +   N  + G        +    +P+ P  L       SPV P  
Sbjct: 1860 --DALQQRP------SVLHNTGMKG--------IITAVEPSTPTVLRSTSTS-SPVRPAA 1902

Query: 629  GAPPTYISPLGG 640
              PP    PLGG
Sbjct: 1903 TFPPATHCPLGG 1914


>gi|149158690 HLA-B associated transcript-2 [Homo sapiens]
          Length = 2157

 Score = 67.8 bits (164), Expect = 3e-11
 Identities = 101/430 (23%), Positives = 142/430 (33%), Gaps = 96/430 (22%)

Query: 283 EAEQAWPQSSGEEELQLQLALAMSKEEADQEERIRRGDDLRLQMAIEESKRETGGKEESS 342
           E +  W  +  E +   +L  +  ++  D +E    G       + EE   E  GK+ +S
Sbjct: 321 ENDDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGAEGHRDSQSASGEERPPEADGKKGNS 380

Query: 343 LMDLADVFTAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGP-PVPPAADP-------W 394
                         P ++P   P P  A   T+ P     G P P PP   P       W
Sbjct: 381 --------------PNSEP---PTPKTAWAETSRPPETEPGPPAPKPPLPPPHRGPAGNW 423

Query: 395 GGPAPTP-ASGDPWRPAAPAGPSVDPWGGTPAPAAGE----------------------- 430
           G P   P   G P +P AP     + W      ++ E                       
Sbjct: 424 GPPGDYPDRGGPPCKPPAPEDED-EAWRQRRKQSSSEISLAVERARRRREEEERRMQEER 482

Query: 431 --------GPTPDPWGSSDGGV---PVSGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTA 479
                       + +G+ D  +   P + P+A     P PA        PA P  +  T 
Sbjct: 483 RAACAEKLKRLDEKFGAPDKRLKAEPAAPPAAPSTPAPPPAVPKELPAPPAPPPASAPTP 542

Query: 480 AGGFDTEPDEFSDFDRLRTALPTSG-SSAGELELLAGEVPARSPGAFDMSGVRGSLAEAV 538
               +TEP+E +     ++  PT G ++A  L    G   + S G+F+ S V   L    
Sbjct: 543 ----ETEPEEPAQAPPAQST-PTPGVAAAPTLVSGGGSTSSTSSGSFEASPVEPQLPSKE 597

Query: 539 GSPPPAATPTPTP--------------PTRKTPESFLGPNAALVDLDSLVSRPGPTPPGA 584
           G  PP   P PT               PTR+ P   LG       L     R        
Sbjct: 598 GPEPPEEVPPPTTPPVPKVEPKGDGIGPTRQPPSQGLGYPKYQKSLPPRFQRQQQEQLLK 657

Query: 585 KAS----NPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLGG 640
           +           G  P T      P  P+PP  +TL  +   P P  P  PP  + P  G
Sbjct: 658 QQQQHQWQQHQQGSAPPT------PVPPSPPQPVTLGAV---PAPQAPPPPPKALYP--G 706

Query: 641 GPGLPPMMPP 650
             G PP MPP
Sbjct: 707 ALGRPPPMPP 716



 Score = 66.2 bits (160), Expect = 9e-11
 Identities = 109/422 (25%), Positives = 143/422 (33%), Gaps = 78/422 (18%)

Query: 281 PPEAEQAWPQSSGEEELQLQLALAMSKEEADQEERIRRGDDLRLQMAIEESKRETGGKEE 340
           P + ++AW Q   +   ++ LA+  ++   ++EER  R  + R     E+ KR       
Sbjct: 442 PEDEDEAWRQRRKQSSSEISLAVERARRRREEEER--RMQEERRAACAEKLKR------- 492

Query: 341 SSLMDLADVFTAPAPAPTTDPWGGP-APMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAP 399
                L + F AP      +P   P AP   A P A P   P   PP PP A      AP
Sbjct: 493 -----LDEKFGAPDKRLKAEPAAPPAAPSTPAPPPAVPKELP--APPAPPPAS-----AP 540

Query: 400 TPASGDPWRPA-APAGPSVDPWGGTPAP--AAGEGPTPDPWGSSDGGVPVSGPSASDPWT 456
           TP + +P  PA AP   S    G   AP   +G G T      S    PV  P       
Sbjct: 541 TPET-EPEEPAQAPPAQSTPTPGVAAAPTLVSGGGSTSSTSSGSFEASPVE-PQLPSKEG 598

Query: 457 PAPAFSDPWGGSPAKPSTNGT-TAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAG 515
           P P    P   +P  P         G     P +   + + + +LP       + +LL  
Sbjct: 599 PEPPEEVPPPTTPPVPKVEPKGDGIGPTRQPPSQGLGYPKYQKSLPPRFQRQQQEQLLKQ 658

Query: 516 E-----------------VPARSPGAFDMSGVRGSLAEAVGSPPPAA-------TPTPTP 551
           +                 VP   P    +  V    A     PPP A        P P P
Sbjct: 659 QQQHQWQQHQQGSAPPTPVPPSPPQPVTLGAVP---APQAPPPPPKALYPGALGRPPPMP 715

Query: 552 PTRKTPESFLGPNAALVDLDSLVSRPGPT--PPGAKASNPFLPGGGPATGPSVTNPFQPA 609
           P    P   + P    VD   L  RP     PPG   S   +P     +G S + PF   
Sbjct: 716 PMNFDPRWMMIP--PYVDPRLLQGRPPLDFYPPGVHPSG-LVPRERSDSGGSSSEPFDRH 772

Query: 610 PPATLTLNQLRLSPVPP-----------VPGAPPTYISPL-----GGGPGLPPMMPPGPP 653
            PA   L +    PV P            P  P    SPL         G+    PP PP
Sbjct: 773 APA--MLRERGTPPVDPKLAWVGDVFTATPAEPRPLTSPLRQAADEDDKGMRSETPPVPP 830

Query: 654 AP 655
            P
Sbjct: 831 PP 832



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 76/303 (25%), Positives = 103/303 (33%), Gaps = 60/303 (19%)

Query: 376  APTSDPWGGPPVPPAADPWGGPAPTPASG-DPWRPAA---------PAGPSVDPWGGTPA 425
            AP   P   P +P A     GP+P P +  +P R  +           GP V   GGTP 
Sbjct: 1492 APGGHPRHKPGLPQAPQ---GPSPRPPTRYEPQRVNSGLSSDPHFEEPGPMVRGVGGTPR 1548

Query: 426  PAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDT 485
             +AG  P P          P       +   P P  S   G  P  P     +   G  T
Sbjct: 1549 DSAGVSPFPPKRRERP---PRKPELLQEESLPPPHSSGFLGSKPEGPGPQAESRDTG--T 1603

Query: 486  EPDEFSDFDRLRTALPTSGSSAGELEL----------LAGEVPARSPGAFDMSGVRGSLA 535
            E      ++RL TA          +E           +AG   ++S    D+SG      
Sbjct: 1604 EALTPHIWNRLHTATSRKSYRPSSMEPWMEPLSPFEDVAGTEMSQSDSGVDLSG-----D 1658

Query: 536  EAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGG 595
              V S P +   +P    +   E   GP            RPG + P             
Sbjct: 1659 SQVSSGPCSQRSSPDGGLKGAAE---GP----------PKRPGGSSP---------LNAV 1696

Query: 596  PATGPSVTNPFQPAPPATLTLNQLRL---SPVPPVP-GAPPTYISPLGGGPG-LPPMMPP 650
            P  GP  + P +  PPA    ++  L    P+PP P G   +  +  G  PG + P   P
Sbjct: 1697 PCEGPPGSEPPRRPPPAPHDGDRKELPREQPLPPGPIGTERSQRTDRGTEPGPIRPSHRP 1756

Query: 651  GPP 653
            GPP
Sbjct: 1757 GPP 1759



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 81/341 (23%), Positives = 104/341 (30%), Gaps = 70/341 (20%)

Query: 355 PAPTTDPWGGPAPMAAAV-PTAAPTSDPWGGPPVPPAADP------------------W- 394
           P PTT P     P    + PT  P S   G P    +  P                  W 
Sbjct: 606 PPPTTPPVPKVEPKGDGIGPTRQPPSQGLGYPKYQKSLPPRFQRQQQEQLLKQQQQHQWQ 665

Query: 395 ----GGPAPTPASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPS 450
               G   PTP    P +P           G  PAP A   P    +  + G  P   P 
Sbjct: 666 QHQQGSAPPTPVPPSPPQPVT--------LGAVPAPQAPPPPPKALYPGALGRPPPMPPM 717

Query: 451 ASDP-WTPAPAFSDP---WGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSS 506
             DP W   P + DP    G  P      G   +G     P E SD          SG S
Sbjct: 718 NFDPRWMMIPPYVDPRLLQGRPPLDFYPPGVHPSG---LVPRERSD----------SGGS 764

Query: 507 AGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAA 566
           + E          R  G   +      + +   + P    P  +P  +   E   G  + 
Sbjct: 765 SSEPFDRHAPAMLRERGTPPVDPKLAWVGDVFTATPAEPRPLTSPLRQAADEDDKGMRSE 824

Query: 567 LVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTN-PFQPAPPATLT----LNQLRL 621
                   + P P PP   AS P  P  G A GP ++  P +   P  L      +++  
Sbjct: 825 --------TPPVPPPPPYLASYPGFPENG-APGPPISRFPLEEPGPRPLPWPPGSDEVAK 875

Query: 622 SPVPPVPGAPPTYISPLGGGP--GLPPMM-----PPGPPAP 655
              PP    PP   +    GP  G  P         GPP P
Sbjct: 876 IQTPPPKKEPPKEETAQLTGPEAGRKPARGVGSGGQGPPPP 916



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 78/301 (25%), Positives = 100/301 (33%), Gaps = 65/301 (21%)

Query: 368  MAAAVPTAAPTSDPWGG-PPVPPAADPW------GGPAPTPAS-GDPWRPAA---PAGPS 416
            + A+V  A P S  W   P    +A+P       G   P P+S G    P      AGPS
Sbjct: 1785 LTASVTEAIPVSRDWELLPSAAASAEPQSKNLDSGHCVPEPSSSGQRLYPEVFYGSAGPS 1844

Query: 417  VDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSDPWGGSPAKPSTNG 476
                 G        G        + GG     PS   P+   P +  P G +P     +G
Sbjct: 1845 SSQISG--------GAMDSQLHPNSGGFRPGTPSLH-PYRSQPLYLPP-GPAPPSALLSG 1894

Query: 477  TTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAE 536
                G       +F DF  ++         A EL  L        P +F  S        
Sbjct: 1895 LALKG-------QFLDFSTMQ---------ATELGKLPAGGVLYPPPSFLYS-------- 1930

Query: 537  AVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGP 596
                  PA  P+P P T     S L     L       S P    PG ++   FLP G P
Sbjct: 1931 ------PAFCPSPLPDT-----SLLQVRQDLPSPSDFYSTP--LQPGGQSG--FLPSGAP 1975

Query: 597  ATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPN 656
            A    +       P     +N   L P PP P  PP  + P+G     P +    PPAP 
Sbjct: 1976 AQQMLLPMVDSQLP----VVNFGSLPPAPP-PAPPPLSLLPVGPALQPPSLAVRPPPAPA 2030

Query: 657  T 657
            T
Sbjct: 2031 T 2031



 Score = 36.6 bits (83), Expect = 0.076
 Identities = 72/280 (25%), Positives = 87/280 (31%), Gaps = 53/280 (18%)

Query: 346  LADVFTAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGD 405
            + DVFTA    P   P   P   AA        S+    PPVPP       P P  AS  
Sbjct: 792  VGDVFTATPAEPR--PLTSPLRQAADEDDKGMRSET---PPVPP-------PPPYLASYP 839

Query: 406  PWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPW--GSSDGGVPVSGPSASDPWTPAPAFSD 463
             +      GP +  +     P    GP P PW  GS +     + P   +P  P    + 
Sbjct: 840  GFPENGAPGPPISRF-----PLEEPGPRPLPWPPGSDEVAKIQTPPPKKEP--PKEETAQ 892

Query: 464  PWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPG 523
              G    +    G   +GG    P         R   P  GSS                 
Sbjct: 893  LTGPEAGRKPARGV-GSGGQGPPPPRRESRTETRWG-PRPGSSR---------------- 934

Query: 524  AFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPG 583
                   RG   E  G+PP  A P   PP     E    P   L   D     P P P  
Sbjct: 935  -------RGIPPEEPGAPPRRAGPIKKPPPPTKVEEL--PPKPLEQGDETPKPPKPDP-- 983

Query: 584  AKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSP 623
             K +   L  GGP   P   N   PAP      +  R+ P
Sbjct: 984  LKITKGKL--GGPKETPPNGN-LSPAPRLRRDYSYERVGP 1020



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 77/307 (25%), Positives = 101/307 (32%), Gaps = 73/307 (23%)

Query: 334 ETGGKEESSLMDLADVFTAPAPAPTTDP-----W---GGPAPMAAAVPTAA--PTSDPWG 383
           +  G ++ +  +      +  P P+  P     W   GG  P     P +      DP G
Sbjct: 174 QAAGDQDKAAKERESAEQSSGPGPSLRPQNSTTWRDGGGRGPDELEGPDSKLHHGHDPRG 233

Query: 384 G--PPVPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSSD 441
           G  P  PP   P+ G  P P    P+ P  P             P   +GP   P     
Sbjct: 234 GLQPSGPPQFPPYRGMMP-PFMYPPYLPFPP-------------PYGPQGPYRYPTPDGP 279

Query: 442 GGVP-VSGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTAL 500
              P V+GP  S P        +P G    +PS            + D   +FD+L    
Sbjct: 280 SRFPRVAGPRGSGP---PMRLVEPVG----RPSI----------LKEDNLKEFDQLDQEN 322

Query: 501 PTSGSSAGE----LELL--AGEVPARSPGAFDMSGVRGSLAEAVGSPPPAA------TPT 548
               + A E     E L  + E   R        G R S + +    PP A      +P 
Sbjct: 323 DDGWAGAHEEVDYTEKLKFSDEEDGRDSDEEGAEGHRDSQSASGEERPPEADGKKGNSPN 382

Query: 549 PTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFL--PGGGPA--TGPSVTN 604
             PPT KT  +               SRP  T PG  A  P L  P  GPA   GP    
Sbjct: 383 SEPPTPKTAWAE-------------TSRPPETEPGPPAPKPPLPPPHRGPAGNWGPPGDY 429

Query: 605 PFQPAPP 611
           P +  PP
Sbjct: 430 PDRGGPP 436



 Score = 33.9 bits (76), Expect = 0.49
 Identities = 54/220 (24%), Positives = 71/220 (32%), Gaps = 19/220 (8%)

Query: 447 SGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGS- 505
           S P +SD  T  P  S P   S    S          +  P   S       A  T G+ 
Sbjct: 93  SDPKSSDASTAQPPESQPLPASQTPASNQPKRPPAAPENTPLVPSGVKSWAQASVTHGAH 152

Query: 506 -SAGELELLAG-----EVPA-RSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTR---- 554
              G    L       E P  ++ G  D +      AE    P P+  P  +   R    
Sbjct: 153 GDGGRASSLLSRFSREEFPTLQAAGDQDKAAKERESAEQSSGPGPSLRPQNSTTWRDGGG 212

Query: 555 KTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATL 614
           + P+   GP++ L        R G  P G     P+     P   P    P+ P PP   
Sbjct: 213 RGPDELEGPDSKLHHGHD--PRGGLQPSGPPQFPPYRGMMPPFMYP----PYLPFPPPYG 266

Query: 615 TLNQLRLSPVPPVPGAPPTYISPLGGGPGLPPMMPPGPPA 654
                R  P P  P   P    P G GP +  + P G P+
Sbjct: 267 PQGPYRY-PTPDGPSRFPRVAGPRGSGPPMRLVEPVGRPS 305



 Score = 33.9 bits (76), Expect = 0.49
 Identities = 66/271 (24%), Positives = 83/271 (30%), Gaps = 26/271 (9%)

Query: 321  DLRLQMAIEESKRETGGKEESSLMDLADVFTAPAPAPTTDPWGGPAPMAAAVPTAAPTSD 380
            D     A E  K   GG        L      P+P P T            V    P+  
Sbjct: 1903 DFSTMQATELGKLPAGGVLYPPPSFLYSPAFCPSPLPDTS--------LLQVRQDLPSPS 1954

Query: 381  PWGGPPVPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDPWGSS 440
             +   P+ P       P+  PA            P V+     PAP     P P P    
Sbjct: 1955 DFYSTPLQPGGQSGFLPSGAPAQQMLLPMVDSQLPVVNFGSLPPAPP----PAPPPLSLL 2010

Query: 441  DGGVPVSGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTAL 500
              G  +  PS +    PAPA       SPA+P       A     E   F D+ +L + L
Sbjct: 2011 PVGPALQPPSLAVRPPPAPATRVL--PSPARPFPASLGRAELHPVELKPFQDYQKLSSNL 2068

Query: 501  --------PTSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPP 552
                    P +G S   L       P+   G F    V         SPP A    P P 
Sbjct: 2069 GGPGSSRTPPTGRSFSGLNSRLKATPSTYSGVFRTQRVD---LYQQASPPDALRWIPKPW 2125

Query: 553  TRKTPESFLGPNAALVDLDSLVSR-PGPTPP 582
             R  P    GP+    +  S   + PG  PP
Sbjct: 2126 ERTGPPPREGPSRRAEEPGSRGDKEPGLPPP 2156



 Score = 31.2 bits (69), Expect = 3.2
 Identities = 35/113 (30%), Positives = 41/113 (36%), Gaps = 26/113 (23%)

Query: 539  GSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPAT 598
            GS PPA  P P PP    P   +GP    +   SL  RP P P     +   LP      
Sbjct: 1994 GSLPPAPPPAP-PPLSLLP---VGP---ALQPPSLAVRPPPAP-----ATRVLPS----- 2036

Query: 599  GPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLGGGPGLPPMMPPG 651
                     PA P   +L +  L PV   P      +S   GGPG     P G
Sbjct: 2037 ---------PARPFPASLGRAELHPVELKPFQDYQKLSSNLGGPGSSRTPPTG 2080



 Score = 30.0 bits (66), Expect = 7.1
 Identities = 71/269 (26%), Positives = 91/269 (33%), Gaps = 49/269 (18%)

Query: 398  APTPASGDPWR-PAAPAGPSVDPWGGTPAPA---AGEGPTPDPWG-----SSDGGVPVSG 448
            APTP  G   + P AP  P   P   +PAPA   A  G    P G        GG P   
Sbjct: 1124 APTPKEGTLTQVPLAPPPPGAPP---SPAPARFTARGGRVFTPRGVPSRRGRGGGRPP-- 1178

Query: 449  PSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAG 508
            P     W+P PA S     +P KP T     +     EP +        + +   GS+ G
Sbjct: 1179 PQVCPGWSP-PAKSL----APKKPPTGPLPPS----KEPLKEKLIPGPLSPVARGGSNGG 1229

Query: 509  E-LELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPP----------AATPTPTPPTRKTP 557
              + +  GE P R          R   A+    PP           AA  +   P+   P
Sbjct: 1230 SNVGMEDGERPRRR---------RHGRAQQQDKPPRFRRLKQERENAARGSEGKPSLTLP 1280

Query: 558  ESFLGPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLN 617
             S  GP  AL  +        P P  A A +P L                 +   T    
Sbjct: 1281 ASAPGPEEALTTVTV-----APAPRRAAAKSPDLSNQNSDQANEEWETASESSDFTSERR 1335

Query: 618  QLRLSPVPPVPGAPPTYISPLGGGPGLPP 646
              + +P PPV   P    +P GGG G  P
Sbjct: 1336 GDKEAP-PPVLLTPKAVGTPGGGGGGAVP 1363



 Score = 29.6 bits (65), Expect = 9.3
 Identities = 42/169 (24%), Positives = 63/169 (37%), Gaps = 21/169 (12%)

Query: 466  GGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPT-SGSSAGELELLAGEVPARSPGA 524
            GG    P+  G TA+    +E  E+ +  + R    + +GS   E +L   +  A +P  
Sbjct: 1071 GGPNHPPAPRGRTASET-RSEGSEYEEIPKRRRQRGSETGSETHESDLAPSDKEAPTPK- 1128

Query: 525  FDMSGVRGSLAEA-VGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPPG 583
                   G+L +  +  PPP A P+P       P  F      +     + SR G    G
Sbjct: 1129 ------EGTLTQVPLAPPPPGAPPSP------APARFTARGGRVFTPRGVPSRRG--RGG 1174

Query: 584  AKASNPFLPGGGPATGPSVTN--PFQPAPPATLTLNQLRLSPVPPVPGA 630
             +      PG  P          P  P PP+   L + +L P P  P A
Sbjct: 1175 GRPPPQVCPGWSPPAKSLAPKKPPTGPLPPSKEPLKE-KLIPGPLSPVA 1222


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 86/331 (25%), Positives = 107/331 (32%), Gaps = 54/331 (16%)

Query: 351 TAPAPAPTTDPWGGPAPMAAAVPT---AAPTSDPWGGPPVP--PAADPWGGPAPT-PASG 404
           T   PAPTT     P       PT   +APT+     P  P  PA      PAPT P   
Sbjct: 266 TTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP 325

Query: 405 DPWRPAAPAGPSVDPWGGTP---APAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAF 461
            P  P  PA  + +P   TP   AP A + P P              P+ + P  PAP  
Sbjct: 326 TPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAP---------TTPKEPAPTTPKEPAPTT 376

Query: 462 S-DPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPAR 520
           + +P   +P +P+   T +A     EP             PT+  SA            +
Sbjct: 377 TKEPSPTTPKEPAPTTTKSAPTTTKEP------------APTTTKSAPTTPKEPSPTTTK 424

Query: 521 SPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPT 580
            P     +  +         P P     P P T K P     P        +    P PT
Sbjct: 425 EPAP---TTPKEPAPTTPKKPAPTTPKEPAPTTPKEP----APTTTKKPAPTTPKEPAPT 477

Query: 581 PPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQL--------------RLSPVPP 626
            P  K + P  P     T P    P  P  PA  T  +L                +P  P
Sbjct: 478 TP--KETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTP 535

Query: 627 VPGAPPTYISPLGGGPGLPPMMPPGPPAPNT 657
              AP T   P    P  P    P  PAP T
Sbjct: 536 KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTT 566



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 81/325 (24%), Positives = 106/325 (32%), Gaps = 27/325 (8%)

Query: 351 TAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPA 410
           T   PAPTT      AP     P    T +P    P  PA      PAPT     P  P 
Sbjct: 243 TPKEPAPTTTK---SAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPK 299

Query: 411 APAGPSVDPWGGT----PAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAP-AFSDPW 465
            PA  +      T    PAP   + PTP      +       P+ + P  PAP A   P 
Sbjct: 300 EPAPTTPKKPAPTTPKEPAPTTPKEPTPTT--PKEPAPTTKEPAPTTPKEPAPTAPKKPA 357

Query: 466 GGSPAKPS-TNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGA 524
             +P +P+ T     A     EP   +  +   T   ++ ++  E      +    +P  
Sbjct: 358 PTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE 417

Query: 525 FDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPT---- 580
              +  +         P P     P P T K P     P        +   +P PT    
Sbjct: 418 PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEP----APTTPKEPAPTTTKKPAPTTPKE 473

Query: 581 --PPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLR-LSPVPPVPGAP--PTYI 635
             P   K + P  P     T P    P  P  PA  T  +L   +P  P P  P  P   
Sbjct: 474 PAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPT 533

Query: 636 SPLGGGPGL---PPMMPPGPPAPNT 657
           +P    P     P    P  PAP T
Sbjct: 534 TPKAAAPNTPKEPAPTTPKEPAPTT 558



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 86/341 (25%), Positives = 113/341 (33%), Gaps = 40/341 (11%)

Query: 331 SKRETGGKEESSLMDLADVFTAPAPAPTTDPWGGPAPMAAAV---PTAAPTSDPWGGPPV 387
           S +ET   E++S  DLA         PT+     P P A      P      +P    P 
Sbjct: 172 SAKETQSIEKTSAKDLA---------PTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPK 222

Query: 388 PPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGT---PAPAAGEGP---TPDPWGSSD 441
            PA+     P PT     P  P  PA  +      T   PAP   + P   TP     + 
Sbjct: 223 EPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTT 282

Query: 442 GGVPVSGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALP 501
              P    + S P TP     +P   +P KP+   TT      T P E +       A P
Sbjct: 283 TKEPAPTTTKSAPTTP----KEPAPTTPKKPAP--TTPKEPAPTTPKEPTPTTPKEPA-P 335

Query: 502 TSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFL 561
           T+   A            + P     +  +         P P  T  P+P T K P    
Sbjct: 336 TTKEPAPTTPKEPAPTAPKKPAP---TTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTT 392

Query: 562 GPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAP-----PATLTL 616
             +A      +    P PT   +  + P  P       P+ T P +PAP     PA  T 
Sbjct: 393 TKSA-----PTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTP 447

Query: 617 NQLRLSPVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNT 657
            +   +P  P   AP T   P    P  P    P   AP T
Sbjct: 448 KE--PAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTT 486



 Score = 59.7 bits (143), Expect = 8e-09
 Identities = 80/316 (25%), Positives = 100/316 (31%), Gaps = 48/316 (15%)

Query: 351 TAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPA 410
           T   PAPTT     PAP     P  APT+     P  P    P      TP + +   P 
Sbjct: 446 TPKEPAPTTPK--EPAPTTTKKP--APTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPT 501

Query: 411 APAGPSVDPWGGTP---APAAGEGPTP----DPWGSSDGGVPVSGPSASDPWTPA-PAFS 462
            P  P+      TP   AP   E PTP    +P  ++      + P    P TP  PA +
Sbjct: 502 TPEKPAPT----TPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPT 557

Query: 463 DPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSP 522
            P   +P  P     T   G  T P        L+   PT+       EL        + 
Sbjct: 558 TPKEPAPTTPKETAPTTPKG--TAPTT------LKEPAPTTPKKPAPKELAPTTTKEPTS 609

Query: 523 GAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPP 582
              D          A  +P   A  TP  P   TP+             + +  P PT P
Sbjct: 610 TTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG---------TAPTTLKEPAPTTP 660

Query: 583 GAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLGGGP 642
              A     P      GP+ T   +PAP               P   AP T   P    P
Sbjct: 661 KKPAPKELAPT--TTKGPTSTTSDKPAPTT-------------PKETAPTTPKEPAPTTP 705

Query: 643 GLPPMMPPGPPAPNTN 658
             P    P  P P T+
Sbjct: 706 KKPAPTTPETPPPTTS 721



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 81/322 (25%), Positives = 108/322 (33%), Gaps = 63/322 (19%)

Query: 351 TAPAPAPTTDPWGGPAPMAAAVPTA----APTSDPWGGPPVPPAADPWGGPAPTPASGDP 406
           T   PAPTT     P       PT     APT+     P  P    P     PTP + + 
Sbjct: 470 TPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEE 529

Query: 407 WRPAAP--AGPSV--DPWGGTP---APAAGEGPTPDPWGSSDGGVP-------VSGPSAS 452
             P  P  A P+   +P   TP   AP   + P P     +    P       +  P+ +
Sbjct: 530 PAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPT 589

Query: 453 DPWTPAP------AFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPT-SGS 505
            P  PAP         +P   +  KP+   TT  G   T P E +       A  T  G+
Sbjct: 590 TPKKPAPKELAPTTTKEPTSTTCDKPAP--TTPKGTAPTTPKEPAPTTPKEPAPTTPKGT 647

Query: 506 SAGELELLAGEVPAR-SPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPN 564
           +   L+  A   P + +P     +  +G  +     P P  TP  T PT  TP+      
Sbjct: 648 APTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPT-TPKETAPT--TPKE----- 699

Query: 565 AALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATL------TLNQ 618
                       P PT P  K   P  P   P T   V+ P     P T+      +  +
Sbjct: 700 ------------PAPTTP--KKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPE 745

Query: 619 LRLSPVPPV-------PGAPPT 633
           L   P P         PG P T
Sbjct: 746 LSAEPTPKALENSPKEPGVPTT 767



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 67/269 (24%), Positives = 92/269 (34%), Gaps = 25/269 (9%)

Query: 351 TAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPA 410
           T   P PTT     PAP       AAP +     P  P    P     P P +     P 
Sbjct: 518 TPEEPTPTTPE--EPAPTTP--KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPT 573

Query: 411 APAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVS---------GPSASDPWTP-APA 460
            P G +       PAP   + P P     +    P S          P  + P TP  PA
Sbjct: 574 TPKGTAPTTL-KEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA 632

Query: 461 FSDPWGGSPAKP-STNGTTAAGGFDTEPDEFSDFDRLRTAL--PTSGSSAGELELLAGEV 517
            + P   +P  P  T  TT      T P + +  +   T    PTS +S         E 
Sbjct: 633 PTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKET 692

Query: 518 PARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESF-LGPNAALVDLDSLVSR 576
              +P     +  +        +PPP  +   TP T K P +    P+ +  +L +    
Sbjct: 693 APTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSA---- 748

Query: 577 PGPTPPGAKASNPFLPGGGPATGPSVTNP 605
             PTP  A  ++P  PG      P+ T P
Sbjct: 749 -EPTPK-ALENSPKEPGVPTTKTPAATKP 775


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 86/331 (25%), Positives = 107/331 (32%), Gaps = 54/331 (16%)

Query: 351 TAPAPAPTTDPWGGPAPMAAAVPT---AAPTSDPWGGPPVP--PAADPWGGPAPT-PASG 404
           T   PAPTT     P       PT   +APT+     P  P  PA      PAPT P   
Sbjct: 307 TTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP 366

Query: 405 DPWRPAAPAGPSVDPWGGTP---APAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAF 461
            P  P  PA  + +P   TP   AP A + P P              P+ + P  PAP  
Sbjct: 367 TPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAP---------TTPKEPAPTTPKEPAPTT 417

Query: 462 S-DPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPAR 520
           + +P   +P +P+   T +A     EP             PT+  SA            +
Sbjct: 418 TKEPSPTTPKEPAPTTTKSAPTTTKEP------------APTTTKSAPTTPKEPSPTTTK 465

Query: 521 SPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPT 580
            P     +  +         P P     P P T K P     P        +    P PT
Sbjct: 466 EPAP---TTPKEPAPTTPKKPAPTTPKEPAPTTPKEP----APTTTKKPAPTTPKEPAPT 518

Query: 581 PPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQL--------------RLSPVPP 626
            P  K + P  P     T P    P  P  PA  T  +L                +P  P
Sbjct: 519 TP--KETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTP 576

Query: 627 VPGAPPTYISPLGGGPGLPPMMPPGPPAPNT 657
              AP T   P    P  P    P  PAP T
Sbjct: 577 KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTT 607



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 81/325 (24%), Positives = 106/325 (32%), Gaps = 27/325 (8%)

Query: 351 TAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPA 410
           T   PAPTT      AP     P    T +P    P  PA      PAPT     P  P 
Sbjct: 284 TPKEPAPTTTK---SAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPK 340

Query: 411 APAGPSVDPWGGT----PAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAP-AFSDPW 465
            PA  +      T    PAP   + PTP      +       P+ + P  PAP A   P 
Sbjct: 341 EPAPTTPKKPAPTTPKEPAPTTPKEPTPTT--PKEPAPTTKEPAPTTPKEPAPTAPKKPA 398

Query: 466 GGSPAKPS-TNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGA 524
             +P +P+ T     A     EP   +  +   T   ++ ++  E      +    +P  
Sbjct: 399 PTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE 458

Query: 525 FDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPT---- 580
              +  +         P P     P P T K P     P        +   +P PT    
Sbjct: 459 PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEP----APTTPKEPAPTTTKKPAPTTPKE 514

Query: 581 --PPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLR-LSPVPPVPGAP--PTYI 635
             P   K + P  P     T P    P  P  PA  T  +L   +P  P P  P  P   
Sbjct: 515 PAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPT 574

Query: 636 SPLGGGPGL---PPMMPPGPPAPNT 657
           +P    P     P    P  PAP T
Sbjct: 575 TPKAAAPNTPKEPAPTTPKEPAPTT 599



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 86/341 (25%), Positives = 113/341 (33%), Gaps = 40/341 (11%)

Query: 331 SKRETGGKEESSLMDLADVFTAPAPAPTTDPWGGPAPMAAAV---PTAAPTSDPWGGPPV 387
           S +ET   E++S  DLA         PT+     P P A      P      +P    P 
Sbjct: 213 SAKETQSIEKTSAKDLA---------PTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPK 263

Query: 388 PPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGT---PAPAAGEGP---TPDPWGSSD 441
            PA+     P PT     P  P  PA  +      T   PAP   + P   TP     + 
Sbjct: 264 EPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTT 323

Query: 442 GGVPVSGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALP 501
              P    + S P TP     +P   +P KP+   TT      T P E +       A P
Sbjct: 324 TKEPAPTTTKSAPTTP----KEPAPTTPKKPAP--TTPKEPAPTTPKEPTPTTPKEPA-P 376

Query: 502 TSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFL 561
           T+   A            + P     +  +         P P  T  P+P T K P    
Sbjct: 377 TTKEPAPTTPKEPAPTAPKKPAP---TTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTT 433

Query: 562 GPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAP-----PATLTL 616
             +A      +    P PT   +  + P  P       P+ T P +PAP     PA  T 
Sbjct: 434 TKSA-----PTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTP 488

Query: 617 NQLRLSPVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNT 657
            +   +P  P   AP T   P    P  P    P   AP T
Sbjct: 489 KE--PAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTT 527



 Score = 59.7 bits (143), Expect = 8e-09
 Identities = 80/316 (25%), Positives = 100/316 (31%), Gaps = 48/316 (15%)

Query: 351 TAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPA 410
           T   PAPTT     PAP     P  APT+     P  P    P      TP + +   P 
Sbjct: 487 TPKEPAPTTPK--EPAPTTTKKP--APTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPT 542

Query: 411 APAGPSVDPWGGTP---APAAGEGPTP----DPWGSSDGGVPVSGPSASDPWTPA-PAFS 462
            P  P+      TP   AP   E PTP    +P  ++      + P    P TP  PA +
Sbjct: 543 TPEKPAPT----TPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPT 598

Query: 463 DPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSP 522
            P   +P  P     T   G  T P        L+   PT+       EL        + 
Sbjct: 599 TPKEPAPTTPKETAPTTPKG--TAPTT------LKEPAPTTPKKPAPKELAPTTTKEPTS 650

Query: 523 GAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPP 582
              D          A  +P   A  TP  P   TP+             + +  P PT P
Sbjct: 651 TTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG---------TAPTTLKEPAPTTP 701

Query: 583 GAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLGGGP 642
              A     P      GP+ T   +PAP               P   AP T   P    P
Sbjct: 702 KKPAPKELAPT--TTKGPTSTTSDKPAPTT-------------PKETAPTTPKEPAPTTP 746

Query: 643 GLPPMMPPGPPAPNTN 658
             P    P  P P T+
Sbjct: 747 KKPAPTTPETPPPTTS 762



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 81/322 (25%), Positives = 108/322 (33%), Gaps = 63/322 (19%)

Query: 351 TAPAPAPTTDPWGGPAPMAAAVPTA----APTSDPWGGPPVPPAADPWGGPAPTPASGDP 406
           T   PAPTT     P       PT     APT+     P  P    P     PTP + + 
Sbjct: 511 TPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEE 570

Query: 407 WRPAAP--AGPSV--DPWGGTP---APAAGEGPTPDPWGSSDGGVP-------VSGPSAS 452
             P  P  A P+   +P   TP   AP   + P P     +    P       +  P+ +
Sbjct: 571 PAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPT 630

Query: 453 DPWTPAP------AFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPT-SGS 505
            P  PAP         +P   +  KP+   TT  G   T P E +       A  T  G+
Sbjct: 631 TPKKPAPKELAPTTTKEPTSTTCDKPAP--TTPKGTAPTTPKEPAPTTPKEPAPTTPKGT 688

Query: 506 SAGELELLAGEVPAR-SPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPN 564
           +   L+  A   P + +P     +  +G  +     P P  TP  T PT  TP+      
Sbjct: 689 APTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPT-TPKETAPT--TPKE----- 740

Query: 565 AALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATL------TLNQ 618
                       P PT P  K   P  P   P T   V+ P     P T+      +  +
Sbjct: 741 ------------PAPTTP--KKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPE 786

Query: 619 LRLSPVPPV-------PGAPPT 633
           L   P P         PG P T
Sbjct: 787 LSAEPTPKALENSPKEPGVPTT 808



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 67/269 (24%), Positives = 92/269 (34%), Gaps = 25/269 (9%)

Query: 351 TAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPA 410
           T   P PTT     PAP       AAP +     P  P    P     P P +     P 
Sbjct: 559 TPEEPTPTTPE--EPAPTTP--KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPT 614

Query: 411 APAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVS---------GPSASDPWTP-APA 460
            P G +       PAP   + P P     +    P S          P  + P TP  PA
Sbjct: 615 TPKGTAPTTL-KEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA 673

Query: 461 FSDPWGGSPAKP-STNGTTAAGGFDTEPDEFSDFDRLRTAL--PTSGSSAGELELLAGEV 517
            + P   +P  P  T  TT      T P + +  +   T    PTS +S         E 
Sbjct: 674 PTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKET 733

Query: 518 PARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESF-LGPNAALVDLDSLVSR 576
              +P     +  +        +PPP  +   TP T K P +    P+ +  +L +    
Sbjct: 734 APTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSA---- 789

Query: 577 PGPTPPGAKASNPFLPGGGPATGPSVTNP 605
             PTP  A  ++P  PG      P+ T P
Sbjct: 790 -EPTPK-ALENSPKEPGVPTTKTPAATKP 816


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 86/331 (25%), Positives = 107/331 (32%), Gaps = 54/331 (16%)

Query: 351 TAPAPAPTTDPWGGPAPMAAAVPT---AAPTSDPWGGPPVP--PAADPWGGPAPT-PASG 404
           T   PAPTT     P       PT   +APT+     P  P  PA      PAPT P   
Sbjct: 359 TTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP 418

Query: 405 DPWRPAAPAGPSVDPWGGTP---APAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAF 461
            P  P  PA  + +P   TP   AP A + P P              P+ + P  PAP  
Sbjct: 419 TPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAP---------TTPKEPAPTTPKEPAPTT 469

Query: 462 S-DPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPAR 520
           + +P   +P +P+   T +A     EP             PT+  SA            +
Sbjct: 470 TKEPSPTTPKEPAPTTTKSAPTTTKEP------------APTTTKSAPTTPKEPSPTTTK 517

Query: 521 SPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPT 580
            P     +  +         P P     P P T K P     P        +    P PT
Sbjct: 518 EPAP---TTPKEPAPTTPKKPAPTTPKEPAPTTPKEP----APTTTKKPAPTTPKEPAPT 570

Query: 581 PPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQL--------------RLSPVPP 626
            P  K + P  P     T P    P  P  PA  T  +L                +P  P
Sbjct: 571 TP--KETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTP 628

Query: 627 VPGAPPTYISPLGGGPGLPPMMPPGPPAPNT 657
              AP T   P    P  P    P  PAP T
Sbjct: 629 KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTT 659



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 81/325 (24%), Positives = 106/325 (32%), Gaps = 27/325 (8%)

Query: 351 TAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPA 410
           T   PAPTT      AP     P    T +P    P  PA      PAPT     P  P 
Sbjct: 336 TPKEPAPTTTK---SAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPK 392

Query: 411 APAGPSVDPWGGT----PAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAP-AFSDPW 465
            PA  +      T    PAP   + PTP      +       P+ + P  PAP A   P 
Sbjct: 393 EPAPTTPKKPAPTTPKEPAPTTPKEPTPTT--PKEPAPTTKEPAPTTPKEPAPTAPKKPA 450

Query: 466 GGSPAKPS-TNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGA 524
             +P +P+ T     A     EP   +  +   T   ++ ++  E      +    +P  
Sbjct: 451 PTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE 510

Query: 525 FDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPT---- 580
              +  +         P P     P P T K P     P        +   +P PT    
Sbjct: 511 PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEP----APTTPKEPAPTTTKKPAPTTPKE 566

Query: 581 --PPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLR-LSPVPPVPGAP--PTYI 635
             P   K + P  P     T P    P  P  PA  T  +L   +P  P P  P  P   
Sbjct: 567 PAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPT 626

Query: 636 SPLGGGPGL---PPMMPPGPPAPNT 657
           +P    P     P    P  PAP T
Sbjct: 627 TPKAAAPNTPKEPAPTTPKEPAPTT 651



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 86/341 (25%), Positives = 113/341 (33%), Gaps = 40/341 (11%)

Query: 331 SKRETGGKEESSLMDLADVFTAPAPAPTTDPWGGPAPMAAAV---PTAAPTSDPWGGPPV 387
           S +ET   E++S  DLA         PT+     P P A      P      +P    P 
Sbjct: 265 SAKETQSIEKTSAKDLA---------PTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPK 315

Query: 388 PPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGT---PAPAAGEGP---TPDPWGSSD 441
            PA+     P PT     P  P  PA  +      T   PAP   + P   TP     + 
Sbjct: 316 EPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTT 375

Query: 442 GGVPVSGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALP 501
              P    + S P TP     +P   +P KP+   TT      T P E +       A P
Sbjct: 376 TKEPAPTTTKSAPTTP----KEPAPTTPKKPAP--TTPKEPAPTTPKEPTPTTPKEPA-P 428

Query: 502 TSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFL 561
           T+   A            + P     +  +         P P  T  P+P T K P    
Sbjct: 429 TTKEPAPTTPKEPAPTAPKKPAP---TTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTT 485

Query: 562 GPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAP-----PATLTL 616
             +A      +    P PT   +  + P  P       P+ T P +PAP     PA  T 
Sbjct: 486 TKSA-----PTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTP 540

Query: 617 NQLRLSPVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNT 657
            +   +P  P   AP T   P    P  P    P   AP T
Sbjct: 541 KE--PAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTT 579



 Score = 59.7 bits (143), Expect = 8e-09
 Identities = 80/316 (25%), Positives = 100/316 (31%), Gaps = 48/316 (15%)

Query: 351 TAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPA 410
           T   PAPTT     PAP     P  APT+     P  P    P      TP + +   P 
Sbjct: 539 TPKEPAPTTPK--EPAPTTTKKP--APTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPT 594

Query: 411 APAGPSVDPWGGTP---APAAGEGPTP----DPWGSSDGGVPVSGPSASDPWTPA-PAFS 462
            P  P+      TP   AP   E PTP    +P  ++      + P    P TP  PA +
Sbjct: 595 TPEKPAPT----TPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPT 650

Query: 463 DPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSP 522
            P   +P  P     T   G  T P        L+   PT+       EL        + 
Sbjct: 651 TPKEPAPTTPKETAPTTPKG--TAPTT------LKEPAPTTPKKPAPKELAPTTTKEPTS 702

Query: 523 GAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPP 582
              D          A  +P   A  TP  P   TP+             + +  P PT P
Sbjct: 703 TTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG---------TAPTTLKEPAPTTP 753

Query: 583 GAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLGGGP 642
              A     P      GP+ T   +PAP               P   AP T   P    P
Sbjct: 754 KKPAPKELAPT--TTKGPTSTTSDKPAPTT-------------PKETAPTTPKEPAPTTP 798

Query: 643 GLPPMMPPGPPAPNTN 658
             P    P  P P T+
Sbjct: 799 KKPAPTTPETPPPTTS 814



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 81/322 (25%), Positives = 108/322 (33%), Gaps = 63/322 (19%)

Query: 351 TAPAPAPTTDPWGGPAPMAAAVPTA----APTSDPWGGPPVPPAADPWGGPAPTPASGDP 406
           T   PAPTT     P       PT     APT+     P  P    P     PTP + + 
Sbjct: 563 TPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEE 622

Query: 407 WRPAAP--AGPSV--DPWGGTP---APAAGEGPTPDPWGSSDGGVP-------VSGPSAS 452
             P  P  A P+   +P   TP   AP   + P P     +    P       +  P+ +
Sbjct: 623 PAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPT 682

Query: 453 DPWTPAP------AFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPT-SGS 505
            P  PAP         +P   +  KP+   TT  G   T P E +       A  T  G+
Sbjct: 683 TPKKPAPKELAPTTTKEPTSTTCDKPAP--TTPKGTAPTTPKEPAPTTPKEPAPTTPKGT 740

Query: 506 SAGELELLAGEVPAR-SPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPN 564
           +   L+  A   P + +P     +  +G  +     P P  TP  T PT  TP+      
Sbjct: 741 APTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPT-TPKETAPT--TPKE----- 792

Query: 565 AALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATL------TLNQ 618
                       P PT P  K   P  P   P T   V+ P     P T+      +  +
Sbjct: 793 ------------PAPTTP--KKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPE 838

Query: 619 LRLSPVPPV-------PGAPPT 633
           L   P P         PG P T
Sbjct: 839 LSAEPTPKALENSPKEPGVPTT 860



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 67/269 (24%), Positives = 92/269 (34%), Gaps = 25/269 (9%)

Query: 351 TAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPA 410
           T   P PTT     PAP       AAP +     P  P    P     P P +     P 
Sbjct: 611 TPEEPTPTTPE--EPAPTTP--KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPT 666

Query: 411 APAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVS---------GPSASDPWTP-APA 460
            P G +       PAP   + P P     +    P S          P  + P TP  PA
Sbjct: 667 TPKGTAPTTL-KEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA 725

Query: 461 FSDPWGGSPAKP-STNGTTAAGGFDTEPDEFSDFDRLRTAL--PTSGSSAGELELLAGEV 517
            + P   +P  P  T  TT      T P + +  +   T    PTS +S         E 
Sbjct: 726 PTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKET 785

Query: 518 PARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESF-LGPNAALVDLDSLVSR 576
              +P     +  +        +PPP  +   TP T K P +    P+ +  +L +    
Sbjct: 786 APTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSA---- 841

Query: 577 PGPTPPGAKASNPFLPGGGPATGPSVTNP 605
             PTP  A  ++P  PG      P+ T P
Sbjct: 842 -EPTPK-ALENSPKEPGVPTTKTPAATKP 868


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 86/331 (25%), Positives = 107/331 (32%), Gaps = 54/331 (16%)

Query: 351 TAPAPAPTTDPWGGPAPMAAAVPT---AAPTSDPWGGPPVP--PAADPWGGPAPT-PASG 404
           T   PAPTT     P       PT   +APT+     P  P  PA      PAPT P   
Sbjct: 400 TTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPKEPAPTTPKKPAPTTPKEPAPTTPKEP 459

Query: 405 DPWRPAAPAGPSVDPWGGTP---APAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAF 461
            P  P  PA  + +P   TP   AP A + P P              P+ + P  PAP  
Sbjct: 460 TPTTPKEPAPTTKEPAPTTPKEPAPTAPKKPAP---------TTPKEPAPTTPKEPAPTT 510

Query: 462 S-DPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPAR 520
           + +P   +P +P+   T +A     EP             PT+  SA            +
Sbjct: 511 TKEPSPTTPKEPAPTTTKSAPTTTKEP------------APTTTKSAPTTPKEPSPTTTK 558

Query: 521 SPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPT 580
            P     +  +         P P     P P T K P     P        +    P PT
Sbjct: 559 EPAP---TTPKEPAPTTPKKPAPTTPKEPAPTTPKEP----APTTTKKPAPTTPKEPAPT 611

Query: 581 PPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQL--------------RLSPVPP 626
            P  K + P  P     T P    P  P  PA  T  +L                +P  P
Sbjct: 612 TP--KETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPTTP 669

Query: 627 VPGAPPTYISPLGGGPGLPPMMPPGPPAPNT 657
              AP T   P    P  P    P  PAP T
Sbjct: 670 KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTT 700



 Score = 65.9 bits (159), Expect = 1e-10
 Identities = 81/325 (24%), Positives = 106/325 (32%), Gaps = 27/325 (8%)

Query: 351 TAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPA 410
           T   PAPTT      AP     P    T +P    P  PA      PAPT     P  P 
Sbjct: 377 TPKEPAPTTTK---SAPTTPKEPAPTTTKEPAPTTPKEPAPTTTKEPAPTTTKSAPTTPK 433

Query: 411 APAGPSVDPWGGT----PAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAP-AFSDPW 465
            PA  +      T    PAP   + PTP      +       P+ + P  PAP A   P 
Sbjct: 434 EPAPTTPKKPAPTTPKEPAPTTPKEPTPTT--PKEPAPTTKEPAPTTPKEPAPTAPKKPA 491

Query: 466 GGSPAKPS-TNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGA 524
             +P +P+ T     A     EP   +  +   T   ++ ++  E      +    +P  
Sbjct: 492 PTTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTTTKSAPTTTKEPAPTTTKSAPTTPKE 551

Query: 525 FDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPT---- 580
              +  +         P P     P P T K P     P        +   +P PT    
Sbjct: 552 PSPTTTKEPAPTTPKEPAPTTPKKPAPTTPKEP----APTTPKEPAPTTTKKPAPTTPKE 607

Query: 581 --PPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLR-LSPVPPVPGAP--PTYI 635
             P   K + P  P     T P    P  P  PA  T  +L   +P  P P  P  P   
Sbjct: 608 PAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEEPAPT 667

Query: 636 SPLGGGPGL---PPMMPPGPPAPNT 657
           +P    P     P    P  PAP T
Sbjct: 668 TPKAAAPNTPKEPAPTTPKEPAPTT 692



 Score = 60.8 bits (146), Expect = 4e-09
 Identities = 86/341 (25%), Positives = 113/341 (33%), Gaps = 40/341 (11%)

Query: 331 SKRETGGKEESSLMDLADVFTAPAPAPTTDPWGGPAPMAAAV---PTAAPTSDPWGGPPV 387
           S +ET   E++S  DLA         PT+     P P A      P      +P    P 
Sbjct: 306 SAKETQSIEKTSAKDLA---------PTSKVLAKPTPKAETTTKGPALTTPKEPTPTTPK 356

Query: 388 PPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGT---PAPAAGEGP---TPDPWGSSD 441
            PA+     P PT     P  P  PA  +      T   PAP   + P   TP     + 
Sbjct: 357 EPASTTPKEPTPTTIKSAPTTPKEPAPTTTKSAPTTPKEPAPTTTKEPAPTTPKEPAPTT 416

Query: 442 GGVPVSGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALP 501
              P    + S P TP     +P   +P KP+   TT      T P E +       A P
Sbjct: 417 TKEPAPTTTKSAPTTP----KEPAPTTPKKPAP--TTPKEPAPTTPKEPTPTTPKEPA-P 469

Query: 502 TSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFL 561
           T+   A            + P     +  +         P P  T  P+P T K P    
Sbjct: 470 TTKEPAPTTPKEPAPTAPKKPAP---TTPKEPAPTTPKEPAPTTTKEPSPTTPKEPAPTT 526

Query: 562 GPNAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAP-----PATLTL 616
             +A      +    P PT   +  + P  P       P+ T P +PAP     PA  T 
Sbjct: 527 TKSA-----PTTTKEPAPTTTKSAPTTPKEPSPTTTKEPAPTTPKEPAPTTPKKPAPTTP 581

Query: 617 NQLRLSPVPPVPGAPPTYISPLGGGPGLPPMMPPGPPAPNT 657
            +   +P  P   AP T   P    P  P    P   AP T
Sbjct: 582 KE--PAPTTPKEPAPTTTKKPAPTTPKEPAPTTPKETAPTT 620



 Score = 59.7 bits (143), Expect = 8e-09
 Identities = 80/316 (25%), Positives = 100/316 (31%), Gaps = 48/316 (15%)

Query: 351 TAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPA 410
           T   PAPTT     PAP     P  APT+     P  P    P      TP + +   P 
Sbjct: 580 TPKEPAPTTPK--EPAPTTTKKP--APTTPKEPAPTTPKETAPTTPKKLTPTTPEKLAPT 635

Query: 411 APAGPSVDPWGGTP---APAAGEGPTP----DPWGSSDGGVPVSGPSASDPWTPA-PAFS 462
            P  P+      TP   AP   E PTP    +P  ++      + P    P TP  PA +
Sbjct: 636 TPEKPAPT----TPEELAPTTPEEPTPTTPEEPAPTTPKAAAPNTPKEPAPTTPKEPAPT 691

Query: 463 DPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSP 522
            P   +P  P     T   G  T P        L+   PT+       EL        + 
Sbjct: 692 TPKEPAPTTPKETAPTTPKG--TAPTT------LKEPAPTTPKKPAPKELAPTTTKEPTS 743

Query: 523 GAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSLVSRPGPTPP 582
              D          A  +P   A  TP  P   TP+             + +  P PT P
Sbjct: 744 TTCDKPAPTTPKGTAPTTPKEPAPTTPKEPAPTTPKG---------TAPTTLKEPAPTTP 794

Query: 583 GAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLGGGP 642
              A     P      GP+ T   +PAP               P   AP T   P    P
Sbjct: 795 KKPAPKELAPT--TTKGPTSTTSDKPAPTT-------------PKETAPTTPKEPAPTTP 839

Query: 643 GLPPMMPPGPPAPNTN 658
             P    P  P P T+
Sbjct: 840 KKPAPTTPETPPPTTS 855



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 81/322 (25%), Positives = 108/322 (33%), Gaps = 63/322 (19%)

Query: 351 TAPAPAPTTDPWGGPAPMAAAVPTA----APTSDPWGGPPVPPAADPWGGPAPTPASGDP 406
           T   PAPTT     P       PT     APT+     P  P    P     PTP + + 
Sbjct: 604 TPKEPAPTTPKETAPTTPKKLTPTTPEKLAPTTPEKPAPTTPEELAPTTPEEPTPTTPEE 663

Query: 407 WRPAAP--AGPSV--DPWGGTP---APAAGEGPTPDPWGSSDGGVP-------VSGPSAS 452
             P  P  A P+   +P   TP   AP   + P P     +    P       +  P+ +
Sbjct: 664 PAPTTPKAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPTTPKGTAPTTLKEPAPT 723

Query: 453 DPWTPAP------AFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPT-SGS 505
            P  PAP         +P   +  KP+   TT  G   T P E +       A  T  G+
Sbjct: 724 TPKKPAPKELAPTTTKEPTSTTCDKPAP--TTPKGTAPTTPKEPAPTTPKEPAPTTPKGT 781

Query: 506 SAGELELLAGEVPAR-SPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPN 564
           +   L+  A   P + +P     +  +G  +     P P  TP  T PT  TP+      
Sbjct: 782 APTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPT-TPKETAPT--TPKE----- 833

Query: 565 AALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATL------TLNQ 618
                       P PT P  K   P  P   P T   V+ P     P T+      +  +
Sbjct: 834 ------------PAPTTP--KKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPE 879

Query: 619 LRLSPVPPV-------PGAPPT 633
           L   P P         PG P T
Sbjct: 880 LSAEPTPKALENSPKEPGVPTT 901



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 67/269 (24%), Positives = 92/269 (34%), Gaps = 25/269 (9%)

Query: 351 TAPAPAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPA 410
           T   P PTT     PAP       AAP +     P  P    P     P P +     P 
Sbjct: 652 TPEEPTPTTPE--EPAPTTP--KAAAPNTPKEPAPTTPKEPAPTTPKEPAPTTPKETAPT 707

Query: 411 APAGPSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVS---------GPSASDPWTP-APA 460
            P G +       PAP   + P P     +    P S          P  + P TP  PA
Sbjct: 708 TPKGTAPTTL-KEPAPTTPKKPAPKELAPTTTKEPTSTTCDKPAPTTPKGTAPTTPKEPA 766

Query: 461 FSDPWGGSPAKP-STNGTTAAGGFDTEPDEFSDFDRLRTAL--PTSGSSAGELELLAGEV 517
            + P   +P  P  T  TT      T P + +  +   T    PTS +S         E 
Sbjct: 767 PTTPKEPAPTTPKGTAPTTLKEPAPTTPKKPAPKELAPTTTKGPTSTTSDKPAPTTPKET 826

Query: 518 PARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESF-LGPNAALVDLDSLVSR 576
              +P     +  +        +PPP  +   TP T K P +    P+ +  +L +    
Sbjct: 827 APTTPKEPAPTTPKKPAPTTPETPPPTTSEVSTPTTTKEPTTIHKSPDESTPELSA---- 882

Query: 577 PGPTPPGAKASNPFLPGGGPATGPSVTNP 605
             PTP  A  ++P  PG      P+ T P
Sbjct: 883 -EPTPK-ALENSPKEPGVPTTKTPAATKP 909


>gi|209571537 proline-rich protein BstNI subfamily 2 [Homo sapiens]
          Length = 416

 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 84/308 (27%), Positives = 100/308 (32%), Gaps = 45/308 (14%)

Query: 361 PWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPW 420
           P GG  P     P   P   P  G   P    P G P   P  GD  R  +P  P   P 
Sbjct: 62  PQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDKSR--SPRSPPGKPQ 119

Query: 421 GGTPAPAAG---EGPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSDPWGGSPAKPSTNGT 477
           G  P P  G   +GP P P G   G  P  G     P  P         G P  P   G 
Sbjct: 120 G--PPPQGGNQPQGPPPPP-GKPQGPPPQGGNKPQGPPPP---------GKPQGPPPQGD 167

Query: 478 TAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEA 537
             +    + P       + +   P  G+          + P   PG       +G     
Sbjct: 168 NKSRSSRSPPG------KPQGPPPQGGNQP--------QGPPPPPGKPQGPPPQGG--NK 211

Query: 538 VGSPPPAATPTPTPPT--RKTPESFLGPNAALVDLDSLVSRP-GPTPPGAKASNPFLPGG 594
              PPP   P   PP    K+  +   P           ++P GP PP  K   P   GG
Sbjct: 212 PQGPPPPGKPQGPPPQGDNKSQSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGG 271

Query: 595 GPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPTYISPLGG----GPGLPPMMPP 650
               GP      Q  PP   + ++   SP P  P  PP    P GG    GP  PP  P 
Sbjct: 272 NKPQGPPPPGKPQGPPPQGGSKSRSSRSP-PGKPQGPP----PQGGNQPQGPPPPPGKPQ 326

Query: 651 GPPAPNTN 658
           GPP    N
Sbjct: 327 GPPPQGGN 334



 Score = 63.2 bits (152), Expect = 8e-10
 Identities = 82/318 (25%), Positives = 96/318 (30%), Gaps = 59/318 (18%)

Query: 361 PWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWR------PAAPAG 414
           P GG  P     P   P   P  G   P    P G P   P  GD         P  P G
Sbjct: 123 PQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSRSSRSPPGKPQG 182

Query: 415 PSVD----PWGGTPAPAAGEGPTPD----PWGSSDGGVPVSGPSASD------------P 454
           P       P G  P P   +GP P     P G    G P   P   D            P
Sbjct: 183 PPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSPPGKP 242

Query: 455 WTPAP-AFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTSGSSAGELELL 513
             P P   + P G  P      G    GG   +P       + +   P  GS +      
Sbjct: 243 QGPPPQGGNQPQGPPPPPGKPQGPPPQGG--NKPQGPPPPGKPQGPPPQGGSKSRS---- 296

Query: 514 AGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAALVDLDSL 573
                +RSP             +  G PPP   P   PP         G N         
Sbjct: 297 -----SRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQ--------GGNKP------- 336

Query: 574 VSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSPVPPVPGAPPT 633
               GP PPG     P  P GG  +  + + P +P  P     N  +  P PP  G P  
Sbjct: 337 ---QGPPPPGKPQGPP--PQGGSKSRSARSPPGKPQGPPQQEGNNPQ-GPPPPAGGNPQQ 390

Query: 634 YISPLGGGPGLPPMMPPG 651
             +P  G P  PP  P G
Sbjct: 391 PQAPPAGQPQGPPRPPQG 408



 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 73/279 (26%), Positives = 80/279 (28%), Gaps = 50/279 (17%)

Query: 388 PPAADPWGGPAPTPASGDPWRPAAPAGPSVD----PWGGTPAPAAGEGPTPDPWGSSDGG 443
           P  A P GG  P    G P  P  P GP       P G  P P   +GP P       G 
Sbjct: 36  PQGAPPQGGNKP---QGPPSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGP 92

Query: 444 VPVSGPSASDPWTPAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFDRLRTALPTS 503
            P   P    P            G P  P   G     G    P +           P  
Sbjct: 93  PPPGKPQGPPPQGDKSRSPRSPPGKPQGPPPQGGNQPQGPPPPPGK-------PQGPPPQ 145

Query: 504 GSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGP 563
           G +  +     G  P   PG       +G         PP     P P     P+     
Sbjct: 146 GGNKPQ-----GPPP---PGKPQGPPPQGDNKSRSSRSPPGKPQGPPPQGGNQPQ----- 192

Query: 564 NAALVDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSP 623
                         GP PP  K   P   GG    GP      Q  PP     +Q   SP
Sbjct: 193 --------------GPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGDNKSQSARSP 238

Query: 624 VPPVPGAPPTYISPLGG----GPGLPPMMPPGPPAPNTN 658
            P  P  PP    P GG    GP  PP  P GPP    N
Sbjct: 239 -PGKPQGPP----PQGGNQPQGPPPPPGKPQGPPPQGGN 272



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 42/163 (25%), Positives = 52/163 (31%), Gaps = 24/163 (14%)

Query: 330 ESKRETGGKEESSLMDLADVFTAPAPAPTTD----PWGGPAPMAAAVPTAAPTSDPWGG- 384
           +S R   GK +       +    P P P       P GG  P     P       P GG 
Sbjct: 233 QSARSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQGGS 292

Query: 385 --------PPVPPAADPWGGPAPTPASGDPWRPAAPAGPSVDPWGGTPAPAAGEGPTPDP 436
                   P  P    P GG  P      P +P  P     +   G P P   +GP P  
Sbjct: 293 KSRSSRSPPGKPQGPPPQGGNQPQGPPPPPGKPQGPPPQGGNKPQGPPPPGKPQGPPPQG 352

Query: 437 WGSSDG-----GVPVSGP--SASDPWTPAPAFSDPWGGSPAKP 472
              S       G P   P    ++P  P P    P GG+P +P
Sbjct: 353 GSKSRSARSPPGKPQGPPQQEGNNPQGPPP----PAGGNPQQP 391



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 34/118 (28%), Positives = 38/118 (32%), Gaps = 21/118 (17%)

Query: 355 PAPTTDPWGGPAPMAAAVPTAAPTSDPWGGPPVPPAADPWGGPAPTPASGDPWRPAAPAG 414
           P P      GP P     P   P   P G P  PP   P GG     A   P +P  P  
Sbjct: 318 PPPPPGKPQGPPPQGGNKPQGPP---PPGKPQGPP---PQGGSKSRSARSPPGKPQGPPQ 371

Query: 415 PSVDPWGGTPAPAAGEGPTPDPWGSSDGGVPVSGPSASDPWTPAPAFSDPWGGSPAKP 472
              +   G P PA G    P              P A  P  P      P GG P++P
Sbjct: 372 QEGNNPQGPPPPAGGNPQQP------------QAPPAGQPQGPP---RPPQGGRPSRP 414


>gi|42544125 splicing factor 1 isoform 2 [Homo sapiens]
          Length = 638

 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 79/286 (27%), Positives = 105/286 (36%), Gaps = 31/286 (10%)

Query: 383 GGPPVPPAADPWGGPAPTPASGDPWRPAAPAG----PSVDPWGGTPAPAAGEGPTPD-PW 437
           G  PVP +     GPA TP +  P RPAAPA     PS+     +  P    GP+   P+
Sbjct: 321 GEAPVPASVGSTSGPATTPLASAP-RPAAPANNPPPPSLMSTTQSRPPWMNSGPSESRPY 379

Query: 438 GSSDGGVPVSGPSASDPWT---PAPAFSDPWGGSPAKPSTNGTTAAGGFDTEPDEFSDFD 494
               GG P  G     P +   P P+ +   GG P + + NG          P   +   
Sbjct: 380 HGMHGGGP--GGPGGGPHSFPHPLPSLTGGHGGHPMQHNPNGPPPPW-MQPPPPPMNQGP 436

Query: 495 RLRTALPTSGSSAGELELLAGEVPARSPGAFDMSGVRGSLAEAVGSPPPAAT--PTPTPP 552
                 P        ++   G  P  S G + +   +G +      PPP     P P PP
Sbjct: 437 H-----PPGHHGPPPMDQYLGSTPVGS-GVYRLHQGKGMMP-----PPPMGMMPPPPPPP 485

Query: 553 TRKTPESFLGPNAALVDLDSLVSRPGPTPP--GAKASNPFLPGGGPATGPSVTNPFQPAP 610
           + + P    GP   L        +P P PP   + AS+  LP     T  + +      P
Sbjct: 486 SGQPPPPPSGP---LPPWQQQQQQPPPPPPPSSSMASSTPLPWQQNTTTTTTSAGTGSIP 542

Query: 611 PATLTLNQLRLSP-VPPVPGAPPTYISPLGGGPGLPPMMPPGPPAP 655
           P          SP  P + G P     P G  P LPP  PP PP P
Sbjct: 543 PWQQQQAAAAASPGAPQMQGNPTMVPLPPGVQPPLPPGAPPPPPPP 588



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 92/356 (25%), Positives = 110/356 (30%), Gaps = 108/356 (30%)

Query: 338 KEESSLMDLADVFTAPAPAPTTDPWGGPA--PMAAAVPTAAPTSDP-------------- 381
           KE  SLM  A++  AP PA +     GPA  P+A+A   AAP ++P              
Sbjct: 311 KEYLSLM--AELGEAPVPA-SVGSTSGPATTPLASAPRPAAPANNPPPPSLMSTTQSRPP 367

Query: 382 W---------------GGPPVPPAADPWGGPAPTPA-----SGDPWRPAAPAGPSVDPWG 421
           W               GG P  P   P   P P P+      G P +   P GP   PW 
Sbjct: 368 WMNSGPSESRPYHGMHGGGPGGPGGGPHSFPHPLPSLTGGHGGHPMQ-HNPNGPP-PPWM 425

Query: 422 GTPAPAAGEGP------TPDPWGSSDGGVPV----------SGPSASDPWTPAPAFSDPW 465
             P P   +GP       P P     G  PV           G     P    P    P 
Sbjct: 426 QPPPPPMNQGPHPPGHHGPPPMDQYLGSTPVGSGVYRLHQGKGMMPPPPMGMMPPPPPPP 485

Query: 466 GGSPAKPSTNGTTAAGGFDTE---PDEFSDFDRLRTALP------TSGSSAGELELLAGE 516
            G P  P +           +   P   S      T LP      T+ +SAG      G 
Sbjct: 486 SGQPPPPPSGPLPPWQQQQQQPPPPPPPSSSMASSTPLPWQQNTTTTTTSAG-----TGS 540

Query: 517 VP---------ARSPGAFDMSGVRGSLAEAVGSPPPAATPTPTPPTRKTPESFLGPNAAL 567
           +P         A SPGA  M G    +    G  PP     P PP               
Sbjct: 541 IPPWQQQQAAAAASPGAPQMQGNPTMVPLPPGVQPPLPPGAPPPP--------------- 585

Query: 568 VDLDSLVSRPGPTPPGAKASNPFLPGGGPATGPSVTNPFQPAPPATLTLNQLRLSP 623
                      P PP   A     P GG   GPS  +   P P  TL   Q +  P
Sbjct: 586 -----------PPPPPGSAGMMIPPRGG--DGPSHESEDFPRPLVTLPGRQPQQRP 628



 Score = 32.7 bits (73), Expect = 1.1
 Identities = 31/98 (31%), Positives = 36/98 (36%), Gaps = 12/98 (12%)

Query: 351 TAPAPAPTTDPWGGPAPMAAAVPTAA-----PTS---DPWGGPPVPPAADPWGGPAPTPA 402
           T  A   +  PW      AAA P A      PT     P   PP+PP A P   P P  +
Sbjct: 533 TTSAGTGSIPPWQQQQAAAAASPGAPQMQGNPTMVPLPPGVQPPLPPGAPPPPPPPPPGS 592

Query: 403 SGDPWRPAAPAGPSVDPWGGTPAPAA---GEGPTPDPW 437
           +G    P    GPS +     P P     G  P   PW
Sbjct: 593 AGMMIPPRGGDGPSHES-EDFPRPLVTLPGRQPQQRPW 629


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.311    0.131    0.404 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 36,795,620
Number of Sequences: 37866
Number of extensions: 2745038
Number of successful extensions: 36259
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 457
Number of HSP's successfully gapped in prelim test: 1866
Number of HSP's that attempted gapping in prelim test: 14652
Number of HSP's gapped (non-prelim): 12456
length of query: 662
length of database: 18,247,518
effective HSP length: 109
effective length of query: 553
effective length of database: 14,120,124
effective search space: 7808428572
effective search space used: 7808428572
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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