Search of human proteins with 194097386

Search of human proteins with 194097386

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|194097386 gamma-aminobutyric acid (GABA) receptor, rho 1
[Homo sapiens]
         (479 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|194097386 gamma-aminobutyric acid (GABA) receptor, rho 1 [Hom...   976   0.0  
gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2 prec...   668   0.0  
gi|157743288 gamma-aminobutyric acid (GABA) receptor, rho 3 [Hom...   556   e-158
gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3 is...   330   1e-90
gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3 iso...   330   1e-90
gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2 iso...   322   6e-88
gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1 p...   318   7e-87
gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta pre...   311   6e-85
gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2 is...   302   4e-82
gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo s...   287   1e-77
gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens]       275   5e-74
gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo...   275   7e-74
gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]       275   7e-74
gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]         275   7e-74
gi|119372310 glycine receptor, alpha 1 isoform 2 precursor [Homo...   273   3e-73
gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens]       268   1e-71
gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens]       266   3e-71
gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precurso...   262   6e-70
gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precur...   262   6e-70
gi|218156328 glycine receptor, alpha 4 precursor [Homo sapiens]       253   3e-67
gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform ...   252   6e-67
gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3 ...   251   1e-66
gi|157389018 gamma-aminobutyric acid A receptor, alpha 6 precurs...   250   2e-66
gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform ...   248   9e-66
gi|4504023 glycine receptor, beta [Homo sapiens]                      246   4e-65
gi|4557603 gamma-aminobutyric acid A receptor, alpha 3 precursor...   241   8e-64
gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo s...   241   1e-63
gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precurs...   241   1e-63
gi|4503861 gamma-aminobutyric acid (GABA) A receptor, alpha 5 pr...   237   2e-62
gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precurso...   233   4e-61

>gi|194097386 gamma-aminobutyric acid (GABA) receptor, rho 1 [Homo
           sapiens]
          Length = 479

 Score =  976 bits (2523), Expect = 0.0
 Identities = 479/479 (100%), Positives = 479/479 (100%)

Query: 1   MLAVPNMRFGIFLLWWGWVLATESRMHWPGREVHEMSKKGRPQRQRREVHEDAHKQVSPI 60
           MLAVPNMRFGIFLLWWGWVLATESRMHWPGREVHEMSKKGRPQRQRREVHEDAHKQVSPI
Sbjct: 1   MLAVPNMRFGIFLLWWGWVLATESRMHWPGREVHEMSKKGRPQRQRREVHEDAHKQVSPI 60

Query: 61  LRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTM 120
           LRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTM
Sbjct: 61  LRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTM 120

Query: 121 TLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRV 180
           TLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRV
Sbjct: 121 TLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRV 180

Query: 181 QPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTD 240
           QPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTD
Sbjct: 181 QPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTD 240

Query: 241 ERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSW 300
           ERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSW
Sbjct: 241 ERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSW 300

Query: 301 VSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVL 360
           VSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVL
Sbjct: 301 VSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVL 360

Query: 361 EYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKP 420
           EYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKP
Sbjct: 361 EYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKP 420

Query: 421 DRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIFS 479
           DRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIFS
Sbjct: 421 DRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIFS 479


>gi|153266866 gamma-aminobutyric acid (GABA) receptor, rho 2
           precursor [Homo sapiens]
          Length = 490

 Score =  668 bits (1724), Expect = 0.0
 Identities = 331/445 (74%), Positives = 380/445 (85%), Gaps = 7/445 (1%)

Query: 41  RPQRQRREVHEDAHKQVSPILRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVG 100
           +P+R+R     +  K  S + +++ D+TK    K +QLLR+D+HDFSMRP FGGPAIPVG
Sbjct: 47  KPKRKRWTGQVEMPKP-SHLYKKNLDVTKIRKGKPQQLLRVDEHDFSMRPAFGGPAIPVG 105

Query: 101 VDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFF 160
           VDVQVESLDSISEVDMDFTMTLYLRHYWKDERL+F S +N SMTFDGRLVKKIWVPD+FF
Sbjct: 106 VDVQVESLDSISEVDMDFTMTLYLRHYWKDERLAFSSASNKSMTFDGRLVKKIWVPDVFF 165

Query: 161 VHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYA 220
           VHSKRSF HDTTTDN+MLRV PDG VLYS+R+TVTAMCNMDFS FPLD+QTCSLE+ESYA
Sbjct: 166 VHSKRSFTHDTTTDNIMLRVFPDGHVLYSMRITVTAMCNMDFSHFPLDSQTCSLELESYA 225

Query: 221 YTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRH 280
           YT++DLMLYWK G++SLKTDE+ISLSQFLIQ+FHTT++LAFYSSTGWYNRLYINFTLRRH
Sbjct: 226 YTDEDLMLYWKNGDESLKTDEKISLSQFLIQKFHTTSRLAFYSSTGWYNRLYINFTLRRH 285

Query: 281 IFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSY 340
           IFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARV LGITTVLTM+TIITGVNASMPRVSY
Sbjct: 286 IFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVSLGITTVLTMTTIITGVNASMPRVSY 345

Query: 341 IKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGN 400
           +KAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKE+KLREK PC  G+   +T MLDG+
Sbjct: 346 VKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKERKLREKFPCMCGMLHSKTMMLDGS 405

Query: 401 YSDGEVNDLDNY----MPENGEKPDRMMVQLTLASERSSPQRKSQRSSYVSMRI--DTHA 454
           YS+ E N L  Y    +    E+ D+++V L L+ E ++ ++K         RI  +THA
Sbjct: 406 YSESEANSLAGYPRSHILTEEERQDKIVVHLGLSGEANAARKKGLLKGQTGFRIFQNTHA 465

Query: 455 IDKYSRIIFPAAYILFNLIYWSIFS 479
           IDKYSR+IFPA+YI FNLIYWS+FS
Sbjct: 466 IDKYSRLIFPASYIFFNLIYWSVFS 490


>gi|157743288 gamma-aminobutyric acid (GABA) receptor, rho 3 [Homo
           sapiens]
          Length = 467

 Score =  556 bits (1433), Expect = e-158
 Identities = 275/418 (65%), Positives = 325/418 (77%), Gaps = 2/418 (0%)

Query: 63  RSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTL 122
           +  D TK+   K EQLL I+D+DF+MRPGFGG  +PVG+DV VES+DSISE +MDFTMT 
Sbjct: 49  KKDDSTKARPQKYEQLLHIEDNDFAMRPGFGGSPVPVGIDVHVESIDSISETNMDFTMTF 108

Query: 123 YLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQP 182
           YLRHYWKDERLSFPST N SMTFD RL +KIWVPD+FFVHSKRSFIHDTT +N+MLRV P
Sbjct: 109 YLRHYWKDERLSFPSTANKSMTFDHRLTRKIWVPDIFFVHSKRSFIHDTTMENIMLRVHP 168

Query: 183 DGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDER 242
           DG VL SLR+TV+AMC MDFSRFPLDTQ CSLE+ESYAY EDDLMLYWK GN SL T+E 
Sbjct: 169 DGNVLLSLRITVSAMCFMDFSRFPLDTQNCSLELESYAYNEDDLMLYWKHGNKSLNTEEH 228

Query: 243 ISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVS 302
           +SLSQF I++F  ++ LAFYSSTGWYNRL+INF LRRH+FFF+LQTYFPA LMVMLSWVS
Sbjct: 229 MSLSQFFIEDFSASSGLAFYSSTGWYNRLFINFVLRRHVFFFVLQTYFPAILMVMLSWVS 288

Query: 303 FWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEY 362
           FWIDRRAVPARV LGITTVLTMSTIIT V+ASMP+VSY+KAVD+YLWVS +FVFLSV+EY
Sbjct: 289 FWIDRRAVPARVSLGITTVLTMSTIITAVSASMPQVSYLKAVDVYLWVSSLFVFLSVIEY 348

Query: 363 AAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDR 422
           AAVNYLTTV+ERK+ K   K+     +   +    DG Y D E++     +  N E   R
Sbjct: 349 AAVNYLTTVEERKQFKKTGKISRMYNIDAVQAMAFDGCYHDSEIDMDQTSLSLNSEDFMR 408

Query: 423 MMVQLTLASERSSPQRKSQRSSYVSMRI--DTHAIDKYSRIIFPAAYILFNLIYWSIF 478
                + +++ S  +R+     +V   I  + H ID YSRI+FP  YILFNL YW ++
Sbjct: 409 RKSICSPSTDSSRIKRRKSLGGHVGRIILENNHVIDTYSRILFPIVYILFNLFYWGVY 466


>gi|12548788 gamma-aminobutyric acid (GABA) A receptor, beta 3
           isoform 2 precursor [Homo sapiens]
          Length = 473

 Score =  330 bits (847), Expect = 1e-90
 Identities = 176/423 (41%), Positives = 268/423 (63%), Gaps = 33/423 (7%)

Query: 84  HDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSM 143
           +D  +RP FGGP + VG+++ + S+D +SEV+MD+T+T+Y + YW+D+RL++ S   L++
Sbjct: 48  YDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAY-SGIPLNL 106

Query: 144 TFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFS 203
           T D R+  ++WVPD +F++ K+SF+H  T  N M+R+ PDG VLY LR+T TA C MD  
Sbjct: 107 TLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLR 166

Query: 204 RFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYS 263
           R+PLD Q C+LEIESY YT DD+  YW+ G+ ++   ERI L QF I E    ++   + 
Sbjct: 167 RYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVF- 225

Query: 264 STGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLT 323
           +TG Y RL ++F L+R+I +F+LQTY P+ L+ +LSWVSFWI+  A  ARV LGITTVLT
Sbjct: 226 ATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLT 285

Query: 324 MSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQ-ERKEQKLREK 382
           M+TI T +  ++P++ Y+KA+D+YL   FVFVFL++LEYA VNY+   +  ++++KL EK
Sbjct: 286 MTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEK 345

Query: 383 LPC---------TSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKP---DRMMVQLTLA 430
                       ++ +      +L       E+N++   + +        D   +Q    
Sbjct: 346 TAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQ 405

Query: 431 S-----------ERSSPQRKS---QRSSYVSMRI----DTHAIDKYSRIIFPAAYILFNL 472
           S           +RS P +K+   +RSS + ++I    D +AID++SRI+FP  + LFNL
Sbjct: 406 SMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNL 465

Query: 473 IYW 475
           +YW
Sbjct: 466 VYW 468


>gi|4503867 gamma-aminobutyric acid (GABA) A receptor, beta 3
           isoform 1 precursor [Homo sapiens]
          Length = 473

 Score =  330 bits (847), Expect = 1e-90
 Identities = 176/423 (41%), Positives = 268/423 (63%), Gaps = 33/423 (7%)

Query: 84  HDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSM 143
           +D  +RP FGGP + VG+++ + S+D +SEV+MD+T+T+Y + YW+D+RL++ S   L++
Sbjct: 48  YDIRLRPDFGGPPVCVGMNIDIASIDMVSEVNMDYTLTMYFQQYWRDKRLAY-SGIPLNL 106

Query: 144 TFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFS 203
           T D R+  ++WVPD +F++ K+SF+H  T  N M+R+ PDG VLY LR+T TA C MD  
Sbjct: 107 TLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLR 166

Query: 204 RFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYS 263
           R+PLD Q C+LEIESY YT DD+  YW+ G+ ++   ERI L QF I E    ++   + 
Sbjct: 167 RYPLDEQNCTLEIESYGYTTDDIEFYWRGGDKAVTGVERIELPQFSIVEHRLVSRNVVF- 225

Query: 264 STGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLT 323
           +TG Y RL ++F L+R+I +F+LQTY P+ L+ +LSWVSFWI+  A  ARV LGITTVLT
Sbjct: 226 ATGAYPRLSLSFRLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLT 285

Query: 324 MSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQ-ERKEQKLREK 382
           M+TI T +  ++P++ Y+KA+D+YL   FVFVFL++LEYA VNY+   +  ++++KL EK
Sbjct: 286 MTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFLALLEYAFVNYIFFGRGPQRQKKLAEK 345

Query: 383 LPC---------TSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKP---DRMMVQLTLA 430
                       ++ +      +L       E+N++   + +        D   +Q    
Sbjct: 346 TAKAKNDRSKSESNRVDAHGNILLTSLEVHNEMNEVSGGIGDTRNSAISFDNSGIQYRKQ 405

Query: 431 S-----------ERSSPQRKS---QRSSYVSMRI----DTHAIDKYSRIIFPAAYILFNL 472
           S           +RS P +K+   +RSS + ++I    D +AID++SRI+FP  + LFNL
Sbjct: 406 SMPREGHGRFLGDRSLPHKKTHLRRRSSQLKIKIPDLTDVNAIDRWSRIVFPFTFSLFNL 465

Query: 473 IYW 475
           +YW
Sbjct: 466 VYW 468


>gi|4503865 gamma-aminobutyric acid (GABA) A receptor, beta 2
           isoform 2 [Homo sapiens]
          Length = 474

 Score =  322 bits (824), Expect = 6e-88
 Identities = 174/428 (40%), Positives = 260/428 (60%), Gaps = 41/428 (9%)

Query: 84  HDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSM 143
           +D  +RP FGGP + VG+++ + S+D +SEV+MD+T+T+Y +  W+D+RLS+ +   L++
Sbjct: 47  YDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSY-NVIPLNL 105

Query: 144 TFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFS 203
           T D R+  ++WVPD +F++ K+SF+H  T  N M+R+ PDG VLY LR+T TA C MD  
Sbjct: 106 TLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLR 165

Query: 204 RFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYS 263
           R+PLD Q C+LEIESY YT DD+  YW+  ++++    +I L QF I ++   TK   + 
Sbjct: 166 RYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVF- 224

Query: 264 STGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLT 323
           STG Y RL ++F L+R+I +F+LQTY P+ L+ +LSWVSFWI+  A  ARV LGITTVLT
Sbjct: 225 STGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLT 284

Query: 324 MSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKLREKL 383
           M+TI T +  ++P++ Y+KA+D+YL   FVFVF+++LEYA VNY+   +  + QK   + 
Sbjct: 285 MTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQKKAAEK 344

Query: 384 PCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGE-----------KPDRMMVQLTLAS- 431
             ++     R   LD N  D   N L + +    E            P   M+    +S 
Sbjct: 345 AASANNEKMR---LDVNKMDPHENILLSTLEIKNEMATSEAVMGLGDPRSTMLAYDASSI 401

Query: 432 -----------------ERSSPQRKS---QRSSYVSMRI----DTHAIDKYSRIIFPAAY 467
                            ER   Q+KS   +R+S + + I    D +AID++SRI FP  +
Sbjct: 402 QYRKAGLPRHSFGRNALERHVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVF 461

Query: 468 ILFNLIYW 475
             FN++YW
Sbjct: 462 SFFNIVYW 469


>gi|194097327 gamma-aminobutyric acid (GABA) A receptor, beta 1
           precursor [Homo sapiens]
          Length = 474

 Score =  318 bits (815), Expect = 7e-87
 Identities = 175/431 (40%), Positives = 252/431 (58%), Gaps = 48/431 (11%)

Query: 84  HDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSM 143
           +D  +RP FGGP + VG+ + V S+D +SEV+MD+T+T+Y +  WKD+RLS+ S   L++
Sbjct: 48  YDIRLRPDFGGPPVDVGMRIDVASIDMVSEVNMDYTLTMYFQQSWKDKRLSY-SGIPLNL 106

Query: 144 TFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFS 203
           T D R+  ++WVPD +F++ K+SF+H  T  N M+R+ PDG VLY LR+T TA C MD  
Sbjct: 107 TLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLR 166

Query: 204 RFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYS 263
           R+PLD Q C+LEIESY YT DD+  YW  G  ++    +I L QF I ++   +K   ++
Sbjct: 167 RYPLDEQNCTLEIESYGYTTDDIEFYWNGGEGAVTGVNKIELPQFSIVDYKMVSKKVEFT 226

Query: 264 STGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLT 323
            TG Y RL ++F L+R+I +F+LQTY P+TL+ +LSWVSFWI+  A  ARV LGITTVLT
Sbjct: 227 -TGAYPRLSLSFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAARVALGITTVLT 285

Query: 324 MSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNY---------------- 367
           M+TI T +  ++P++ Y+KA+DIYL   FVFVFL++LEYA VNY                
Sbjct: 286 MTTISTHLRETLPKIPYVKAIDIYLMGCFVFVFLALLEYAFVNYIFFGKGPQKKGASKQD 345

Query: 368 -----------------------LTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDG 404
                                  L+T++ R E    E L   S    P+  M    YS  
Sbjct: 346 QSANEKNKLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVS---DPKATM----YSYD 398

Query: 405 EVNDLDNYMPENGEKPDRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFP 464
             +        + E   R + +  + S+    +R SQ    +    D ++IDK+SR+ FP
Sbjct: 399 SASIQYRKPLSSREAYGRALDRHGVPSKGRIRRRASQLKVKIPDLTDVNSIDKWSRMFFP 458

Query: 465 AAYILFNLIYW 475
             + LFN++YW
Sbjct: 459 ITFSLFNVVYW 469


>gi|34734071 gamma-aminobutyric acid (GABA) A receptor, delta
           precursor [Homo sapiens]
          Length = 452

 Score =  311 bits (798), Expect = 6e-85
 Identities = 153/401 (38%), Positives = 247/401 (61%), Gaps = 11/401 (2%)

Query: 87  SMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFD 146
           + RPG GGP + V + ++V S+D ISE +M++TMT++L   W+D RLS+  TN  ++  D
Sbjct: 54  NFRPGIGGPPVNVALALEVASIDHISEANMEYTMTVFLHQSWRDSRLSYNHTNE-TLGLD 112

Query: 147 GRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFP 206
            R V K+W+PD F V++K ++ HD T +N ++R+QPDG +LYS+R+T T  C+MD +++P
Sbjct: 113 SRFVDKLWLPDTFIVNAKSAWFHDVTVENKLIRLQPDGVILYSIRITSTVACDMDLAKYP 172

Query: 207 LDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTG 266
           +D Q C L++ESY Y+ +D++ YW +  + +   +++ L+QF I  +  TT+L  + S G
Sbjct: 173 MDEQECMLDLESYGYSSEDIVYYWSESQEHIHGLDKLQLAQFTITSYRFTTELMNFKSAG 232

Query: 267 WYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMST 326
            + RL ++F LRR+   +++Q+Y P+ L+V +SWVSFWI + AVPARV LGITTVLTM+T
Sbjct: 233 QFPRLSLHFHLRRNRGVYIIQSYMPSVLLVAMSWVSFWISQAAVPARVSLGITTVLTMTT 292

Query: 327 IITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKLREKLPCT 386
           ++    +S+PR S IKA+D+Y W+ +VFVF +++EYA  ++      RK+QK + K+   
Sbjct: 293 LMVSARSSLPRASAIKALDVYFWICYVFVFAALVEYAFAHF--NADYRKKQKAKVKVSRP 350

Query: 387 SGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMM-------VQLTLASERSSPQRK 439
                 R A++  + S   V             P  +M       V+     +  + +  
Sbjct: 351 RAEMDVRNAIVLFSLSAAGVTQELAISRRQRRVPGNLMGSYRSVGVETGETKKEGAARSG 410

Query: 440 SQRSSYVSMR-IDTHAIDKYSRIIFPAAYILFNLIYWSIFS 479
            Q      +R ID   ID Y+R +FPAA+   N+IYW+ ++
Sbjct: 411 GQGGIRARLRPIDADTIDIYARAVFPAAFAAVNVIYWAAYA 451


>gi|12548785 gamma-aminobutyric acid (GABA) A receptor, beta 2
           isoform 1 [Homo sapiens]
          Length = 512

 Score =  302 bits (774), Expect = 4e-82
 Identities = 142/295 (48%), Positives = 210/295 (71%), Gaps = 2/295 (0%)

Query: 84  HDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSM 143
           +D  +RP FGGP + VG+++ + S+D +SEV+MD+T+T+Y +  W+D+RLS+ +   L++
Sbjct: 47  YDIRLRPDFGGPPVAVGMNIDIASIDMVSEVNMDYTLTMYFQQAWRDKRLSY-NVIPLNL 105

Query: 144 TFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFS 203
           T D R+  ++WVPD +F++ K+SF+H  T  N M+R+ PDG VLY LR+T TA C MD  
Sbjct: 106 TLDNRVADQLWVPDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITTTAACMMDLR 165

Query: 204 RFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYS 263
           R+PLD Q C+LEIESY YT DD+  YW+  ++++    +I L QF I ++   TK   + 
Sbjct: 166 RYPLDEQNCTLEIESYGYTTDDIEFYWRGDDNAVTGVTKIELPQFSIVDYKLITKKVVF- 224

Query: 264 STGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLT 323
           STG Y RL ++F L+R+I +F+LQTY P+ L+ +LSWVSFWI+  A  ARV LGITTVLT
Sbjct: 225 STGSYPRLSLSFKLKRNIGYFILQTYMPSILITILSWVSFWINYDASAARVALGITTVLT 284

Query: 324 MSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQK 378
           M+TI T +  ++P++ Y+KA+D+YL   FVFVF+++LEYA VNY+   +  + QK
Sbjct: 285 MTTINTHLRETLPKIPYVKAIDMYLMGCFVFVFMALLEYALVNYIFFGRGPQRQK 339



 Score = 42.7 bits (99), Expect = 7e-04
 Identities = 31/109 (28%), Positives = 54/109 (49%), Gaps = 8/109 (7%)

Query: 368 LTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQL 427
           L+T++ + E    E +    GL  PR+ ML   Y    +      +P +     R  ++ 
Sbjct: 406 LSTLEIKNEMATSEAV---MGLGDPRSTMLA--YDASSIQYRKAGLPRHSF--GRNALER 458

Query: 428 TLASERSSPQRK-SQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYW 475
            +A ++S  +R+ SQ    +    D +AID++SRI FP  +  FN++YW
Sbjct: 459 HVAQKKSRLRRRASQLKITIPDLTDVNAIDRWSRIFFPVVFSFFNIVYW 507


>gi|7657106 gamma-aminobutyric acid (GABA) A receptor, pi [Homo
           sapiens]
          Length = 440

 Score =  287 bits (735), Expect = 1e-77
 Identities = 151/409 (36%), Positives = 242/409 (59%), Gaps = 41/409 (10%)

Query: 88  MRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDG 147
           +RP FGG  + + + + + S+ SISE +MD+T T+YLR  W D+RL F    N S T D 
Sbjct: 52  LRPNFGGEPVQIALTLDIASISSISESNMDYTATIYLRQRWMDQRLVFEG--NKSFTLDA 109

Query: 148 RLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPL 207
           RLV+ +WVPD + V SK+SF+H+ T  N ++R+  +G VLY+LR+T T  CNMD S++P+
Sbjct: 110 RLVEFLWVPDTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTTVACNMDLSKYPM 169

Query: 208 DTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGW 267
           DTQTC L++ES+ Y  +D+   W +GNDS++  E + L+Q+ I+ + T    +    TG 
Sbjct: 170 DTQTCKLQLESWGYDGNDVEFTWLRGNDSVRGLEHLRLAQYTIERYFTLVTRS-QQETGN 228

Query: 268 YNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTI 327
           Y RL + F LRR++ +F+L+TY P+T +V+LSWVSFWI   +VPAR  +G+TTVL+M+T+
Sbjct: 229 YTRLVLQFELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPARTCIGVTTVLSMTTL 288

Query: 328 ITGVNASMPRVS-YIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQ----ERKEQKLREK 382
           + G   S+P  + +IKA+D+YL + F FVF ++LEYA  +Y +  Q    +R   K  E+
Sbjct: 289 MIGSRTSLPNTNCFIKAIDVYLGICFSFVFGALLEYAVAHYSSLQQMAAKDRGTTKEVEE 348

Query: 383 LPCTSGLPPPRTAML-------------DGNYSDGEVNDLDNYMPENGEKPDRMMVQLTL 429
           +  T+ +    ++               + +YSD  +   D +     EK  R++   T+
Sbjct: 349 VSITNIINSSISSFKRKISFASIEISSDNVDYSDLTMKTSDKFKFVFREKMGRIVDYFTI 408

Query: 430 ASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIF 478
            +  +                    +D YS+++FP  ++L N+ YW+ +
Sbjct: 409 QNPSN--------------------VDHYSKLLFPLIFMLANVFYWAYY 437


>gi|169646728 glycine receptor, alpha 2 isoform B [Homo sapiens]
          Length = 452

 Score =  275 bits (704), Expect = 5e-74
 Identities = 151/416 (36%), Positives = 240/416 (57%), Gaps = 16/416 (3%)

Query: 63  RSPDITKSPLTKSEQLL-RIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMT 121
           + P  T SP    ++L+ R   +D  +RP F GP + V  ++ + S  SI+E  MD+ + 
Sbjct: 36  KQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVN 95

Query: 122 LYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQ 181
           ++LR  W D RL++    + S+  D  ++  IW PD+FF + K +  HD TTDN +LR+ 
Sbjct: 96  IFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRIS 155

Query: 182 PDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDE 241
            +GKVLYS+R+T+T  C MD   FP+D QTC++++ES+ YT +DL+  W   +  ++  E
Sbjct: 156 KNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEW-LSDGPVQVAE 214

Query: 242 RISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWV 301
            ++L QF+++E         + +TG +  + + F L R + ++L+Q Y P+ L+V+LSWV
Sbjct: 215 GLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWV 274

Query: 302 SFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLE 361
           SFWI+  A PARV LGITTVLTM+T  +G  AS+P+VSY+KA+DI++ V  +FVF ++LE
Sbjct: 275 SFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLE 334

Query: 362 YAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPD 421
           YAAVN+++  Q ++  +LR +          R    +    +   N     M    +  D
Sbjct: 335 YAAVNFVSR-QHKEFLRLRRR--------QKRQNKEEDVTRESRFNFSGYGMGHCLQVKD 385

Query: 422 RMMVQLTLASERSSPQRKSQ--RSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYW 475
              V+ T A+    P +     +  +V        ID  SR  FP A+++FN+ YW
Sbjct: 386 GTAVKATPANPLPQPPKDGDAIKKKFVDR---AKRIDTISRAAFPLAFLIFNIFYW 438


>gi|225903367 glycine receptor, alpha 1 isoform 1 precursor [Homo
           sapiens]
          Length = 457

 Score =  275 bits (703), Expect = 7e-74
 Identities = 151/421 (35%), Positives = 243/421 (57%), Gaps = 9/421 (2%)

Query: 63  RSPDITKSPLTKSEQLL-RIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMT 121
           RS     SP    ++L+ R   +D  +RP F GP + V  ++ + S  SI+E  MD+ + 
Sbjct: 30  RSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVN 89

Query: 122 LYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQ 181
           ++LR  W D RL++    + S+  D  ++  IW PD+FF + K +  H+ TTDN +LR+ 
Sbjct: 90  IFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRIS 149

Query: 182 PDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDE 241
            +G VLYS+R+T+T  C MD   FP+D QTC +++ES+ YT +DL+  W++   +++  +
Sbjct: 150 RNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQE-QGAVQVAD 208

Query: 242 RISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWV 301
            ++L QF+++E         + +TG +  +   F L R + ++L+Q Y P+ L+V+LSW+
Sbjct: 209 GLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWI 268

Query: 302 SFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLE 361
           SFWI+  A PARV LGITTVLTM+T  +G  AS+P+VSY+KA+DI++ V  +FVF ++LE
Sbjct: 269 SFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLE 328

Query: 362 YAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYM-PENGEKP 420
           YAAVN+   V  + ++ LR +        P      +    +G  N     M P   +  
Sbjct: 329 YAAVNF---VSRQHKELLRFRRKRRHHKSPMLNLFQEDEAGEGRFNFSAYGMGPACLQAK 385

Query: 421 DRMMVQLTLASERSSPQRKSQRSSYVSMRI---DTHAIDKYSRIIFPAAYILFNLIYWSI 477
           D + V+    S  ++P     +S     ++       IDK SRI FP A+++FN+ YW I
Sbjct: 386 DGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWII 445

Query: 478 F 478
           +
Sbjct: 446 Y 446


>gi|169646723 glycine receptor, alpha 2 isoform A [Homo sapiens]
          Length = 452

 Score =  275 bits (703), Expect = 7e-74
 Identities = 150/416 (36%), Positives = 240/416 (57%), Gaps = 16/416 (3%)

Query: 63  RSPDITKSPLTKSEQLL-RIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMT 121
           + P  T SP    ++L+ R   +D  +RP F GP + V  ++ + S  S++E  MD+ + 
Sbjct: 36  KQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVN 95

Query: 122 LYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQ 181
           ++LR  W D RL++    + S+  D  ++  IW PD+FF + K +  HD TTDN +LR+ 
Sbjct: 96  IFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRIS 155

Query: 182 PDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDE 241
            +GKVLYS+R+T+T  C MD   FP+D QTC++++ES+ YT +DL+  W   +  ++  E
Sbjct: 156 KNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEW-LSDGPVQVAE 214

Query: 242 RISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWV 301
            ++L QF+++E         + +TG +  + + F L R + ++L+Q Y P+ L+V+LSWV
Sbjct: 215 GLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWV 274

Query: 302 SFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLE 361
           SFWI+  A PARV LGITTVLTM+T  +G  AS+P+VSY+KA+DI++ V  +FVF ++LE
Sbjct: 275 SFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLE 334

Query: 362 YAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPD 421
           YAAVN+++  Q ++  +LR +          R    +    +   N     M    +  D
Sbjct: 335 YAAVNFVSR-QHKEFLRLRRR--------QKRQNKEEDVTRESRFNFSGYGMGHCLQVKD 385

Query: 422 RMMVQLTLASERSSPQRKSQ--RSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYW 475
              V+ T A+    P +     +  +V        ID  SR  FP A+++FN+ YW
Sbjct: 386 GTAVKATPANPLPQPPKDGDAIKKKFVDR---AKRIDTISRAAFPLAFLIFNIFYW 438


>gi|4504021 glycine receptor, alpha 2 isoform A [Homo sapiens]
          Length = 452

 Score =  275 bits (703), Expect = 7e-74
 Identities = 150/416 (36%), Positives = 240/416 (57%), Gaps = 16/416 (3%)

Query: 63  RSPDITKSPLTKSEQLL-RIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMT 121
           + P  T SP    ++L+ R   +D  +RP F GP + V  ++ + S  S++E  MD+ + 
Sbjct: 36  KQPSQTLSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSVTETTMDYRVN 95

Query: 122 LYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQ 181
           ++LR  W D RL++    + S+  D  ++  IW PD+FF + K +  HD TTDN +LR+ 
Sbjct: 96  IFLRQQWNDSRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHDVTTDNKLLRIS 155

Query: 182 PDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDE 241
            +GKVLYS+R+T+T  C MD   FP+D QTC++++ES+ YT +DL+  W   +  ++  E
Sbjct: 156 KNGKVLYSIRLTLTLSCPMDLKNFPMDVQTCTMQLESFGYTMNDLIFEW-LSDGPVQVAE 214

Query: 242 RISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWV 301
            ++L QF+++E         + +TG +  + + F L R + ++L+Q Y P+ L+V+LSWV
Sbjct: 215 GLTLPQFILKEEKELGYCTKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWV 274

Query: 302 SFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLE 361
           SFWI+  A PARV LGITTVLTM+T  +G  AS+P+VSY+KA+DI++ V  +FVF ++LE
Sbjct: 275 SFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLE 334

Query: 362 YAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPD 421
           YAAVN+++  Q ++  +LR +          R    +    +   N     M    +  D
Sbjct: 335 YAAVNFVSR-QHKEFLRLRRR--------QKRQNKEEDVTRESRFNFSGYGMGHCLQVKD 385

Query: 422 RMMVQLTLASERSSPQRKSQ--RSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYW 475
              V+ T A+    P +     +  +V        ID  SR  FP A+++FN+ YW
Sbjct: 386 GTAVKATPANPLPQPPKDGDAIKKKFVDR---AKRIDTISRAAFPLAFLIFNIFYW 438


>gi|119372310 glycine receptor, alpha 1 isoform 2 precursor [Homo
           sapiens]
          Length = 449

 Score =  273 bits (698), Expect = 3e-73
 Identities = 151/421 (35%), Positives = 244/421 (57%), Gaps = 17/421 (4%)

Query: 63  RSPDITKSPLTKSEQLL-RIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMT 121
           RS     SP    ++L+ R   +D  +RP F GP + V  ++ + S  SI+E  MD+ + 
Sbjct: 30  RSAPKPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVSCNIFINSFGSIAETTMDYRVN 89

Query: 122 LYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQ 181
           ++LR  W D RL++    + S+  D  ++  IW PD+FF + K +  H+ TTDN +LR+ 
Sbjct: 90  IFLRQQWNDPRLAYNEYPDDSLDLDPSMLDSIWKPDLFFANEKGAHFHEITTDNKLLRIS 149

Query: 182 PDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDE 241
            +G VLYS+R+T+T  C MD   FP+D QTC +++ES+ YT +DL+  W++   +++  +
Sbjct: 150 RNGNVLYSIRITLTLACPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEWQE-QGAVQVAD 208

Query: 242 RISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWV 301
            ++L QF+++E         + +TG +  +   F L R + ++L+Q Y P+ L+V+LSW+
Sbjct: 209 GLTLPQFILKEEKDLRYCTKHYNTGKFTCIEARFHLERQMGYYLIQMYIPSLLIVILSWI 268

Query: 302 SFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLE 361
           SFWI+  A PARV LGITTVLTM+T  +G  AS+P+VSY+KA+DI++ V  +FVF ++LE
Sbjct: 269 SFWINMDAAPARVGLGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLE 328

Query: 362 YAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYM-PENGEKP 420
           YAAVN+++  Q ++  + R K          R    +    +G  N     M P   +  
Sbjct: 329 YAAVNFVSR-QHKELLRFRRK----------RRHHKEDEAGEGRFNFSAYGMGPACLQAK 377

Query: 421 DRMMVQLTLASERSSPQRKSQRSSYVSMRI---DTHAIDKYSRIIFPAAYILFNLIYWSI 477
           D + V+    S  ++P     +S     ++       IDK SRI FP A+++FN+ YW I
Sbjct: 378 DGISVKGANNSNTTNPPPAPSKSPEEMRKLFIQRAKKIDKISRIGFPMAFLIFNMFYWII 437

Query: 478 F 478
           +
Sbjct: 438 Y 438


>gi|110347433 glycine receptor, alpha 3 isoform b [Homo sapiens]
          Length = 449

 Score =  268 bits (684), Expect = 1e-71
 Identities = 150/418 (35%), Positives = 239/418 (57%), Gaps = 18/418 (4%)

Query: 63  RSPDITKSPLTKSEQLL-RIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMT 121
           RS     SP    ++L+ R   +D  +RP F GP + V  ++ + S  SI+E  MD+ + 
Sbjct: 35  RSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVN 94

Query: 122 LYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQ 181
           ++LR  W D RL++    + S+  D  ++  IW PD+FF + K +  H+ TTDN +LR+ 
Sbjct: 95  IFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIF 154

Query: 182 PDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDE 241
            +G VLYS+R+T+T  C MD   FP+D QTC +++ES+ YT +DL+  W +    ++  E
Sbjct: 155 KNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEW-QDEAPVQVAE 213

Query: 242 RISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWV 301
            ++L QFL++E         + +TG +  + + F L R + ++L+Q Y P+ L+V+LSWV
Sbjct: 214 GLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWV 273

Query: 302 SFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLE 361
           SFWI+  A PARV LGITTVLTM+T  +G  AS+P+VSY+KA+DI++ V  +FVF ++LE
Sbjct: 274 SFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLE 333

Query: 362 YAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGE-VNDLDNYMPENGEKP 420
           YAAVN+++   +   +  R++      +   R +     Y  G  +   D   P+    P
Sbjct: 334 YAAVNFVSRQHKELLRFRRKRKNKDDEVRESRFSFT--AYGMGPCLQAKDGMTPKGPNHP 391

Query: 421 DRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIF 478
            ++M +        SP     R  ++        ID  SR  FP A+++FN+ YW I+
Sbjct: 392 VQVMPK--------SPD--EMRKVFIDR---AKKIDTISRACFPLAFLIFNIFYWVIY 436


>gi|110347441 glycine receptor, alpha 3 isoform a [Homo sapiens]
          Length = 464

 Score =  266 bits (680), Expect = 3e-71
 Identities = 148/420 (35%), Positives = 235/420 (55%), Gaps = 7/420 (1%)

Query: 63  RSPDITKSPLTKSEQLL-RIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMT 121
           RS     SP    ++L+ R   +D  +RP F GP + V  ++ + S  SI+E  MD+ + 
Sbjct: 35  RSRSAPMSPSDFLDKLMGRTSGYDARIRPNFKGPPVNVTCNIFINSFGSIAETTMDYRVN 94

Query: 122 LYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQ 181
           ++LR  W D RL++    + S+  D  ++  IW PD+FF + K +  H+ TTDN +LR+ 
Sbjct: 95  IFLRQKWNDPRLAYSEYPDDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIF 154

Query: 182 PDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDE 241
            +G VLYS+R+T+T  C MD   FP+D QTC +++ES+ YT +DL+  W +    ++  E
Sbjct: 155 KNGNVLYSIRLTLTLSCPMDLKNFPMDVQTCIMQLESFGYTMNDLIFEW-QDEAPVQVAE 213

Query: 242 RISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWV 301
            ++L QFL++E         + +TG +  + + F L R + ++L+Q Y P+ L+V+LSWV
Sbjct: 214 GLTLPQFLLKEEKDLRYCTKHYNTGKFTCIEVRFHLERQMGYYLIQMYIPSLLIVILSWV 273

Query: 302 SFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLE 361
           SFWI+  A PARV LGITTVLTM+T  +G  AS+P+VSY+KA+DI++ V  +FVF ++LE
Sbjct: 274 SFWINMDAAPARVALGITTVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFSALLE 333

Query: 362 YAAVNYLTTVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPD 421
           YAAVN+++   +   +  R++   T      +         D EV +        G  P 
Sbjct: 334 YAAVNFVSRQHKELLRFRRKRKNKTEAFALEKFYRFSD--MDDEVRESRFSFTAYGMGPC 391

Query: 422 RMMVQLTLASERSSPQRKSQRSSYVSMRI---DTHAIDKYSRIIFPAAYILFNLIYWSIF 478
                       + P +   +S     ++       ID  SR  FP A+++FN+ YW I+
Sbjct: 392 LQAKDGMTPKGPNHPVQVMPKSPDEMRKVFIDRAKKIDTISRACFPLAFLIFNIFYWVIY 451


>gi|31742490 gamma-aminobutyric acid A receptor, gamma 1 precursor
           [Homo sapiens]
          Length = 465

 Score =  262 bits (669), Expect = 6e-70
 Identities = 152/416 (36%), Positives = 233/416 (56%), Gaps = 16/416 (3%)

Query: 64  SPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLY 123
           +P I +  +T+    L +  +D  +RP  G     +  DV V S+  +  ++M++T+ + 
Sbjct: 56  APKIHEGDITQILNSL-LQGYDNKLRPDIGVRPTVIETDVYVNSIGPVDPINMEYTIDII 114

Query: 124 LRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPD 183
               W D RL F ST  + M  +  +V KIW+PD FF +S++S  H  TT N +LR+  D
Sbjct: 115 FAQTWFDSRLKFNSTMKVLM-LNSNMVGKIWIPDTFFRNSRKSDAHWITTPNRLLRIWND 173

Query: 184 GKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERI 243
           G+VLY+LR+T+ A C +    FP+D  +C LE  SY Y ++++   WKK +  +   +  
Sbjct: 174 GRVLYTLRLTINAECYLQLHNFPMDEHSCPLEFSSYGYPKNEIEYKWKKPSVEVADPKYW 233

Query: 244 SLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSF 303
            L QF       +T++  ++ +G Y  + I F L R + +F +QTY P  L V+LSWVSF
Sbjct: 234 RLYQFAFVGLRNSTEIT-HTISGDYVIMTIFFDLSRRMGYFTIQTYIPCILTVVLSWVSF 292

Query: 304 WIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYA 363
           WI++ AVPAR  LGITTVLTM+T+ T    S+P+VSY+ A+D+++ V F+FVF +++EY 
Sbjct: 293 WINKDAVPARTSLGITTVLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFAALMEYG 352

Query: 364 AVNYLTTVQE----RKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEK 419
            ++Y T+ Q+     K++KL+ K   T GL P  T +   N S   V   D+Y  +  E 
Sbjct: 353 TLHYFTSNQKGKTATKDRKLKNKASMTPGLHPGSTLIPMNNIS---VPQEDDYGYQCLEG 409

Query: 420 PDRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYW 475
            D           R+   R+ +      + I    ID YSRI FP A+ LFNL+YW
Sbjct: 410 KDCASFFCCFEDCRTGSWREGR------IHIRIAKIDSYSRIFFPTAFALFNLVYW 459


>gi|8924258 gamma-aminobutyric acid (GABA) receptor, theta precursor
           [Homo sapiens]
          Length = 632

 Score =  262 bits (669), Expect = 6e-70
 Identities = 124/324 (38%), Positives = 202/324 (62%), Gaps = 2/324 (0%)

Query: 84  HDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSM 143
           +D  +RP FGG  +PV + + V S++ ISE++MD+T+T++    WKD RL++  T  L++
Sbjct: 70  YDVRLRPNFGGAPVPVRISIYVTSIEQISEMNMDYTITMFFHQTWKDSRLAYYETT-LNL 128

Query: 144 TFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFS 203
           T D R+ +K+WVPD +F++SK +F+HD T +N + ++ PDG V Y +R+T TA C++D  
Sbjct: 129 TLDYRMHEKLWVPDCYFLNSKDAFVHDVTVENRVFQLHPDGTVRYGIRLTTTAACSLDLH 188

Query: 204 RFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYS 263
           +FP+D Q C+L +ESY YT +D++L+W    +++   E + + QF      T T    Y 
Sbjct: 189 KFPMDKQACNLVVESYGYTVEDIILFWDDNGNAIHMTEELHIPQFTFLG-RTITSKEVYF 247

Query: 264 STGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLT 323
            TG Y RL + F ++R +  +L+Q Y+P  L  + SW+SFW++  +  ARV +G+T++L 
Sbjct: 248 YTGSYIRLILKFQVQREVNSYLVQVYWPTVLTTITSWISFWMNYDSSAARVTIGLTSMLI 307

Query: 324 MSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKLREKL 383
           ++TI + +   +P +S IKA+DIY+ V   FVFLS+LEY  +NYL   +  + Q  R + 
Sbjct: 308 LTTIDSHLRDKLPNISCIKAIDIYILVCLFFVFLSLLEYVYINYLFYSRGPRRQPRRHRR 367

Query: 384 PCTSGLPPPRTAMLDGNYSDGEVN 407
           P           ++ GN  DG +N
Sbjct: 368 PRRVIARYRYQQVVVGNVQDGLIN 391



 Score = 35.8 bits (81), Expect = 0.088
 Identities = 12/21 (57%), Positives = 18/21 (85%)

Query: 455 IDKYSRIIFPAAYILFNLIYW 475
           +DK+SR +FP A+ LFN++YW
Sbjct: 607 VDKWSRFLFPLAFGLFNIVYW 627


>gi|218156328 glycine receptor, alpha 4 precursor [Homo sapiens]
          Length = 417

 Score =  253 bits (646), Expect = 3e-67
 Identities = 121/303 (39%), Positives = 197/303 (65%), Gaps = 1/303 (0%)

Query: 80  RIDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTN 139
           R   +D  +RP F GP + V  ++ + S  SI++  MD+ + ++LR  W D RLS+    
Sbjct: 54  RTSGYDARIRPNFKGPPVNVTCNIFINSFSSITKTTMDYRVNVFLRQQWNDPRLSYREYP 113

Query: 140 NLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCN 199
           + S+  D  ++  IW PD+FF + K +  H+ TTDN +LR+  +G VLYS+R+T+   C 
Sbjct: 114 DDSLDLDPSMLDSIWKPDLFFANEKGANFHEVTTDNKLLRIFKNGNVLYSIRLTLILSCL 173

Query: 200 MDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKL 259
           MD   FP+D QTC++++ES+ YT  DL+  W +   +++  E ++L QF++++       
Sbjct: 174 MDLKNFPMDIQTCTMQLESFGYTMKDLVFEWLEDAPAVQVAEGLTLPQFILRDEKDLGCC 233

Query: 260 AFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGIT 319
             + +TG +  + + F L R + ++L+Q Y P+ L+V+LSWVSFWI+  A PARV LGIT
Sbjct: 234 TKHYNTGKFTCIEVKFHLERQMGYYLIQMYIPSLLIVILSWVSFWINMDAAPARVGLGIT 293

Query: 320 TVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKL 379
           TVLTM+T  +G  AS+P+VSY+KA+DI++ V  +FVF ++LEYAA+N+++  Q ++  +L
Sbjct: 294 TVLTMTTQSSGSRASLPKVSYVKAIDIWMAVCLLFVFAALLEYAAINFVSR-QHKEFIRL 352

Query: 380 REK 382
           R +
Sbjct: 353 RRR 355


>gi|38788135 gamma-aminobutyric acid A receptor, gamma 2 isoform 2
           precursor [Homo sapiens]
          Length = 467

 Score =  252 bits (643), Expect = 6e-67
 Identities = 137/396 (34%), Positives = 225/396 (56%), Gaps = 9/396 (2%)

Query: 81  IDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNN 140
           ++ +D  +RP  G     +  D+ V S+  ++ ++M++T+ ++    W D RL F ST  
Sbjct: 74  LEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIK 133

Query: 141 LSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNM 200
           + +  +  +V KIW+PD FF +SK++  H  TT N MLR+  DG+VLY+LR+T+ A C +
Sbjct: 134 V-LRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQL 192

Query: 201 DFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLA 260
               FP+D  +C LE  SY Y  ++++  WK+ +  +       L QF       TT++ 
Sbjct: 193 QLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVV 252

Query: 261 FYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITT 320
             +++G Y  + + F L R + +F +QTY P TL+V+LSWVSFWI++ AVPAR  LGITT
Sbjct: 253 -KTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITT 311

Query: 321 VLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQE-RKEQKL 379
           VLTM+T+ T    S+P+VSY+ A+D+++ V F+FVF +++EY  ++Y  + ++  K++  
Sbjct: 312 VLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDK 371

Query: 380 REKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQLTLASERSSPQRK 439
           ++K P  +    PR+A +  N +       + Y  E  +  D           R+   R 
Sbjct: 372 KKKNPAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFEDCRTGAWRH 431

Query: 440 SQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYW 475
            +      + I    +D Y+RI FP A+ LFNL+YW
Sbjct: 432 GR------IHIRIAKMDSYARIFFPTAFCLFNLVYW 461


>gi|110347416 gamma-aminobutyric acid (GABA) A receptor, gamma 3
           [Homo sapiens]
          Length = 467

 Score =  251 bits (640), Expect = 1e-66
 Identities = 152/455 (33%), Positives = 238/455 (52%), Gaps = 31/455 (6%)

Query: 41  RPQRQRREVHEDAHKQVSPILRRSPDITKSPLTKSEQLLRIDDHDFSMRPGFGGPAIPVG 100
           R ++   + +ED+      +L      T   L  ++ LLR  ++D  +RP  G     + 
Sbjct: 18  RSRKVEEDEYEDSSSNQKWVLAPKSQDTDVTLILNK-LLR--EYDKKLRPDIGIKPTVID 74

Query: 101 VDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFF 160
           VD+ V S+  +S ++M++ + ++    W D RL F ST  + +T +  +V  IW+PD  F
Sbjct: 75  VDIYVNSIGPVSSINMEYQIDIFFAQTWTDSRLRFNSTMKI-LTLNSNMVGLIWIPDTIF 133

Query: 161 VHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYA 220
            +SK +  H  TT N +LR+  DGK+LY+LR+T+ A C +    FP+D  +C L   SY 
Sbjct: 134 RNSKTAEAHWITTPNQLLRIWNDGKILYTLRLTINAECQLQLHNFPMDEHSCPLIFSSYG 193

Query: 221 YTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRH 280
           Y +++++  W+K +      +   L QF       TT++   +S G Y  + I F L R 
Sbjct: 194 YPKEEMIYRWRKNSVEAADQKSWRLYQFDFMGLRNTTEIVT-TSAGDYVVMTIYFELSRR 252

Query: 281 IFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSY 340
           + +F +QTY P  L V+LSWVSFWI + A PAR  LGITTVLTM+T+ T    S+PRVSY
Sbjct: 253 MGYFTIQTYIPCILTVVLSWVSFWIKKDATPARTALGITTVLTMTTLSTIARKSLPRVSY 312

Query: 341 IKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKLREKL--PCTS----------- 387
           + A+D+++ V F+FVF +++EYA +NY ++ ++    K    L  P +S           
Sbjct: 313 VTAMDLFVTVCFLFVFAALMEYATLNYYSSCRKPTTTKKTTSLLHPDSSRWIPERISLQA 372

Query: 388 -------GLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQLTLASERSSPQRKS 440
                   + PP TAM+  N S       D  + E  +  D           +S   RK 
Sbjct: 373 PSNYSLLDMRPPPTAMITLNNSVYWQEFEDTCVYECLDGKDCQSFFCCYEECKSGSWRKG 432

Query: 441 QRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYW 475
           +      + ID   +D YSR+ FP +++LFNL+YW
Sbjct: 433 R------IHIDILELDSYSRVFFPTSFLLFNLVYW 461


>gi|157389018 gamma-aminobutyric acid A receptor, alpha 6 precursor
           [Homo sapiens]
          Length = 453

 Score =  250 bits (638), Expect = 2e-66
 Identities = 144/413 (34%), Positives = 226/413 (54%), Gaps = 27/413 (6%)

Query: 81  IDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNN 140
           ++ +D  +RPGFGG    V  D+ V S   +S+V+M++TM ++ R  W DERL F     
Sbjct: 40  LEGYDNRLRPGFGGAVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWTDERLKFGGPTE 99

Query: 141 LSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNM 200
           + ++ +  +V KIW PD FF + K+S  H+ TT N + R+  +G +LY++R+T+ A C M
Sbjct: 100 I-LSLNNLMVSKIWTPDTFFRNGKKSIAHNMTTPNKLFRIMQNGTILYTMRLTINADCPM 158

Query: 201 DFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGN--DSLKTDERISLSQF-LIQEFHTTT 257
               FP+D   C L+  SYAY + +++  WKKG        +E  SL Q+ LI +  T +
Sbjct: 159 RLVNFPMDGHACPLKFGSYAYPKSEIIYTWKKGPLYSVEVPEESSSLLQYDLIGQ--TVS 216

Query: 258 KLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLG 317
                S+TG Y  + + F L+R + +F++Q Y P  + V+LS VSFWI++ +VPAR   G
Sbjct: 217 SETIKSNTGEYVIMTVYFHLQRKMGYFMIQIYTPCIMTVILSQVSFWINKESVPARTVFG 276

Query: 318 ITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQ 377
           ITTVLTM+T+      S+P+VSY  A+D ++ V F FVF +++E+AAVNY T +Q +K +
Sbjct: 277 ITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNLQTQKAK 336

Query: 378 KLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQLTLASERSSPQ 437
           +  +        PP  T        + E+       P++     + +  L+L    SS  
Sbjct: 337 RKAQ-----FAAPPTVTISKATEPLEAEI----VLHPDSKYHLKKRITSLSLPIVSSSEA 387

Query: 438 RKSQRSSYVSMRI------------DTHAIDKYSRIIFPAAYILFNLIYWSIF 478
            K    + +                 T  ID+YSRI+FP A+  FNL+YW ++
Sbjct: 388 NKVLTRAPILQSTPVTPPPLSPAFGGTSKIDQYSRILFPVAFAGFNLVYWVVY 440


>gi|38788155 gamma-aminobutyric acid A receptor, gamma 2 isoform 1
           precursor [Homo sapiens]
          Length = 475

 Score =  248 bits (633), Expect = 9e-66
 Identities = 139/404 (34%), Positives = 225/404 (55%), Gaps = 17/404 (4%)

Query: 81  IDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNN 140
           ++ +D  +RP  G     +  D+ V S+  ++ ++M++T+ ++    W D RL F ST  
Sbjct: 74  LEGYDNKLRPDIGVKPTLIHTDMYVNSIGPVNAINMEYTIDIFFAQTWYDRRLKFNSTIK 133

Query: 141 LSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNM 200
           + +  +  +V KIW+PD FF +SK++  H  TT N MLR+  DG+VLY+LR+T+ A C +
Sbjct: 134 V-LRLNSNMVGKIWIPDTFFRNSKKADAHWITTPNRMLRIWNDGRVLYTLRLTIDAECQL 192

Query: 201 DFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEFHTTTKLA 260
               FP+D  +C LE  SY Y  ++++  WK+ +  +       L QF       TT++ 
Sbjct: 193 QLHNFPMDEHSCPLEFSSYGYPREEIVYQWKRSSVEVGDTRSWRLYQFSFVGLRNTTEVV 252

Query: 261 FYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITT 320
             +++G Y  + + F L R + +F +QTY P TL+V+LSWVSFWI++ AVPAR  LGITT
Sbjct: 253 -KTTSGDYVVMSVYFDLSRRMGYFTIQTYIPCTLIVVLSWVSFWINKDAVPARTSLGITT 311

Query: 321 VLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQKLR 380
           VLTM+T+ T    S+P+VSY+ A+D+++ V F+FVF +++EY  ++Y  + ++  + K +
Sbjct: 312 VLTMTTLSTIARKSLPKVSYVTAMDLFVSVCFIFVFSALVEYGTLHYFVSNRKPSKDKDK 371

Query: 381 EK----LPCTSGLPP-----PRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQLTLAS 431
           +K    L   S   P     PR+A +  N +       + Y  E  +  D          
Sbjct: 372 KKKNPLLRMFSFKAPTIDIRPRSATIQMNNATHLQERDEEYGYECLDGKDCASFFCCFED 431

Query: 432 ERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYW 475
            R+   R  +      + I    +D Y+RI FP A+ LFNL+YW
Sbjct: 432 CRTGAWRHGR------IHIRIAKMDSYARIFFPTAFCLFNLVYW 469


>gi|4504023 glycine receptor, beta [Homo sapiens]
          Length = 497

 Score =  246 bits (627), Expect = 4e-65
 Identities = 161/488 (32%), Positives = 260/488 (53%), Gaps = 64/488 (13%)

Query: 37  SKKGRPQRQRREVHEDAHKQVSPILRRSPDITKSPLTKSEQLLR--IDDHDFSMRPGFGG 94
           SKKG+ ++++          + P  + + D+ + P   +  +L   +  +D  +RP F G
Sbjct: 27  SKKGKGKKKQ---------YLCPSQQSAEDLARVPANSTSNILNRLLVSYDPRIRPNFKG 77

Query: 95  PAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPST--NNLSMTFDGRLVKK 152
             + V V++ + S  SI E  MD+ + ++LR  W D RL  PS    + ++T D  + K 
Sbjct: 78  IPVDVVVNIFINSFGSIQETTMDYRVNIFLRQKWNDPRLKLPSDFRGSDALTVDPTMYKC 137

Query: 153 IWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNMDFSRFPLDTQTC 212
           +W PD+FF + K +  HD T +N++L +  DG VL S+R+++T  C +D + FP+DTQ C
Sbjct: 138 LWKPDLFFANEKSANFHDVTQENILLFIFRDGDVLVSMRLSITLSCPLDLTLFPMDTQRC 197

Query: 213 SLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQ----EFHTTTKLAFYSSTGWY 268
            +++ES+ YT DDL   W+ G D ++  E+I+L QF I+    E+   TK  +Y  TG+Y
Sbjct: 198 KMQLESFGYTTDDLRFIWQSG-DPVQL-EKIALPQFDIKKEDIEYGNCTK--YYKGTGYY 253

Query: 269 NRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGITTVLTMSTII 328
             + + FTLRR + F+++  Y P  L+V+LSW+SFWI+  A  ARVPLGI +VL++++  
Sbjct: 254 TCVEVIFTLRRQVGFYMMGVYAPTLLIVVLSWLSFWINPDASAARVPLGIFSVLSLASEC 313

Query: 329 TGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKE-QKLR------- 380
           T + A +P+VSY+KA+D++L    +F F S++EYA V  +    +R E +K R       
Sbjct: 314 TTLAAELPKVSYVKALDVWLIACLLFGFASLVEYAVVQVMLNNPKRVEAEKARIAKAEQA 373

Query: 381 -------EKLPCTSGLPPP-----------RTAMLDGNYSDGEVNDLD--NYMPENGE-- 418
                   K    +G   P           R   +  + SD   ND      +P + E  
Sbjct: 374 DGKGGNVAKKNTVNGTGTPVHISTLQVGETRCKKVCTSKSDLRSNDFSIVGSLPRDFELS 433

Query: 419 ------KPDRMMVQLTLASERSSPQRKSQRSSYVSMRIDTHA--IDKYSRIIFPAAYILF 470
                 KP  + V   L   ++   +K   +  V   I T A  ID Y+R +FP  ++ F
Sbjct: 434 NYDCYGKP--IEVNNGLGKSQAKNNKKPPPAKPV---IPTAAKRIDLYARALFPFCFLFF 488

Query: 471 NLIYWSIF 478
           N+IYWSI+
Sbjct: 489 NVIYWSIY 496


>gi|4557603 gamma-aminobutyric acid A receptor, alpha 3 precursor
           [Homo sapiens]
          Length = 492

 Score =  241 bits (616), Expect = 8e-64
 Identities = 144/428 (33%), Positives = 233/428 (54%), Gaps = 20/428 (4%)

Query: 65  PDITKSPLTKSEQLLR--IDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTL 122
           PD +   +T   ++L   +D +D  +RPG G     V  D+ V S   +S+ DM++T+ +
Sbjct: 57  PDDSTDNITIFTRILDRLLDGYDNRLRPGLGDAVTEVKTDIYVTSFGPVSDTDMEYTIDV 116

Query: 123 YLRHYWKDERLSFPSTNNLSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQP 182
           + R  W DERL F     + +  +  L  KIW PD FF + K+S  H+ TT N +LR+  
Sbjct: 117 FFRQTWHDERLKFDGPMKI-LPLNNLLASKIWTPDTFFHNGKKSVAHNMTTPNKLLRLVD 175

Query: 183 DGKVLYSLRVTVTAMCNMDFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKG-NDSLKTDE 241
           +G +LY++R+T+ A C M    FP+D   C L+  SYAYT  +++  W  G N S++  +
Sbjct: 176 NGTLLYTMRLTIHAECPMHLEDFPMDVHACPLKFGSYAYTTAEVVYSWTLGKNKSVEVAQ 235

Query: 242 RIS-LSQFLIQEFHTTTKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSW 300
             S L+Q+ +      T++   SSTG Y  +  +F L+R I +F++QTY P  + V+LS 
Sbjct: 236 DGSRLNQYDLLGHVVGTEI-IRSSTGEYVVMTTHFHLKRKIGYFVIQTYLPCIMTVILSQ 294

Query: 301 VSFWIDRRAVPARVPLGITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVL 360
           VSFW++R +VPAR   G+TTVLTM+T+      S+P+V+Y  A+D ++ V + FVF +++
Sbjct: 295 VSFWLNRESVPARTVFGVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALI 354

Query: 361 EYAAVNYLT----TVQERKEQKLREKLPCTSGLPPPRTA----MLDGNYSDGEVNDLDNY 412
           E+A VNY T      + +K  +  E    T   P  +T+    ++   Y      D +  
Sbjct: 355 EFATVNYFTKRSWAWEGKKVPEALEMKKKTPAAPAKKTSTTFNIVGTTYPINLAKDTEFS 414

Query: 413 MPENGEKPDRMMVQLTLASERSSPQRKS--QRSSYVSMRIDTHAIDKYSRIIFPAAYILF 470
               G  P        +AS +++  + S  +  +Y S+      +DK SRIIFP  + +F
Sbjct: 415 TISKGAAPSASSTPTIIASPKATYVQDSPTETKTYNSV----SKVDKISRIIFPVLFAIF 470

Query: 471 NLIYWSIF 478
           NL+YW+ +
Sbjct: 471 NLVYWATY 478


>gi|167000817 gamma-aminobutyric acid A receptor, alpha 2 [Homo
           sapiens]
          Length = 451

 Score =  241 bits (614), Expect = 1e-63
 Identities = 137/414 (33%), Positives = 221/414 (53%), Gaps = 39/414 (9%)

Query: 81  IDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNN 140
           +D +D  +RPG G     V  ++ V S   +S+ DM++T+ ++ R  WKDERL F    N
Sbjct: 50  LDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMN 109

Query: 141 LSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNM 200
           + +  +  +  KIW PD FF + K+S  H+ T  N +LR+Q DG +LY++R+TV A C M
Sbjct: 110 I-LRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPM 168

Query: 201 DFSRFPLDTQTCSLEIESYAYTEDDLMLYWK-KGNDSLKT---DERISLSQFLIQEFHTT 256
               FP+D  +C L+  SYAYT  ++   W    +DS++      R++    L Q     
Sbjct: 169 HLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKE 228

Query: 257 TKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPL 316
           T     SSTG Y  +  +F L+R I +F++QTY P  + V+LS VSFW++R +VPAR   
Sbjct: 229 T---IKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVF 285

Query: 317 GITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLT------- 369
           G+TTVLTM+T+      S+P+V+Y  A+D ++ V + FVF +++E+A VNY T       
Sbjct: 286 GVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWD 345

Query: 370 ---TVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQ 426
               V ++K++K               + M+  N        + NY P   + P  ++  
Sbjct: 346 GKSVVNDKKKEK--------------ASVMIQNN---AYAVAVANYAPNLSKDP--VLST 386

Query: 427 LTLASERSSPQRKSQRSSYVSMRI--DTHAIDKYSRIIFPAAYILFNLIYWSIF 478
           ++ ++    P +K +     + +       ID+ SRI+FP  +  FNL+YW+ +
Sbjct: 387 ISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRMSRIVFPVLFGTFNLVYWATY 440


>gi|167000751 gamma-aminobutyric acid A receptor, alpha 2 precursor
           [Homo sapiens]
          Length = 451

 Score =  241 bits (614), Expect = 1e-63
 Identities = 137/414 (33%), Positives = 221/414 (53%), Gaps = 39/414 (9%)

Query: 81  IDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNN 140
           +D +D  +RPG G     V  ++ V S   +S+ DM++T+ ++ R  WKDERL F    N
Sbjct: 50  LDGYDNRLRPGLGDSITEVFTNIYVTSFGPVSDTDMEYTIDVFFRQKWKDERLKFKGPMN 109

Query: 141 LSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNM 200
           + +  +  +  KIW PD FF + K+S  H+ T  N +LR+Q DG +LY++R+TV A C M
Sbjct: 110 I-LRLNNLMASKIWTPDTFFHNGKKSVAHNMTMPNKLLRIQDDGTLLYTMRLTVQAECPM 168

Query: 201 DFSRFPLDTQTCSLEIESYAYTEDDLMLYWK-KGNDSLKT---DERISLSQFLIQEFHTT 256
               FP+D  +C L+  SYAYT  ++   W    +DS++      R++    L Q     
Sbjct: 169 HLEDFPMDAHSCPLKFGSYAYTTSEVTYIWTYNASDSVQVAPDGSRLNQYDLLGQSIGKE 228

Query: 257 TKLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPL 316
           T     SSTG Y  +  +F L+R I +F++QTY P  + V+LS VSFW++R +VPAR   
Sbjct: 229 T---IKSSTGEYTVMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVF 285

Query: 317 GITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLT------- 369
           G+TTVLTM+T+      S+P+V+Y  A+D ++ V + FVF +++E+A VNY T       
Sbjct: 286 GVTTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWD 345

Query: 370 ---TVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPENGEKPDRMMVQ 426
               V ++K++K               + M+  N        + NY P   + P  ++  
Sbjct: 346 GKSVVNDKKKEK--------------ASVMIQNN---AYAVAVANYAPNLSKDP--VLST 386

Query: 427 LTLASERSSPQRKSQRSSYVSMRI--DTHAIDKYSRIIFPAAYILFNLIYWSIF 478
           ++ ++    P +K +     + +       ID+ SRI+FP  +  FNL+YW+ +
Sbjct: 387 ISKSATTPEPNKKPENKPAEAKKTFNSVSKIDRMSRIVFPVLFGTFNLVYWATY 440


>gi|4503861 gamma-aminobutyric acid (GABA) A receptor, alpha 5
           precursor [Homo sapiens]
          Length = 462

 Score =  237 bits (604), Expect = 2e-62
 Identities = 135/412 (32%), Positives = 221/412 (53%), Gaps = 34/412 (8%)

Query: 81  IDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNN 140
           +D +D  +RPG G     V  D+ V S   +S+ +M++T+ ++ R  WKDERL F     
Sbjct: 57  LDGYDNRLRPGLGERITQVRTDIYVTSFGPVSDTEMEYTIDVFFRQSWKDERLRFKGPMQ 116

Query: 141 LSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNM 200
             +  +  L  KIW PD FF + K+S  H+ TT N +LR++ DG +LY++R+T++A C M
Sbjct: 117 -RLPLNNLLASKIWTPDTFFHNGKKSIAHNMTTPNKLLRLEDDGTLLYTMRLTISAECPM 175

Query: 201 DFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDS--LKTDERISLSQFLIQEFHTTTK 258
               FP+D   C L+  SYAY   +++  W  G+    +  ++   L+Q+ +      T+
Sbjct: 176 QLEDFPMDAHACPLKFGSYAYPNSEVVYVWTNGSTKSVVVAEDGSRLNQYHLMGQTVGTE 235

Query: 259 LAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLGI 318
               +STG Y  +  +F L+R I +F++QTY P  + V+LS VSFW++R +VPAR   G+
Sbjct: 236 -NISTSTGEYTIMTAHFHLKRKIGYFVIQTYLPCIMTVILSQVSFWLNRESVPARTVFGV 294

Query: 319 TTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLT--------- 369
           TTVLTM+T+      S+P+V+Y  A+D ++ V + FVF +++E+A VNY T         
Sbjct: 295 TTVLTMTTLSISARNSLPKVAYATAMDWFIAVCYAFVFSALIEFATVNYFTKRGWAWDGK 354

Query: 370 -TVQERKEQKLREKLPCTSGLPPPRTAMLDGNYSDGEVNDLDNYMPEN--GEKPDRMMVQ 426
             ++  K +K RE +   S             ++ G+++   N   E       +   V 
Sbjct: 355 KALEAAKIKKKREVILNKS----------TNAFTTGKMSHPPNIPKEQTPAGTSNTTSVS 404

Query: 427 LTLASERSSPQRKSQRSSYVSMRIDTHAIDKYSRIIFPAAYILFNLIYWSIF 478
           +  + E++S  +K+  S           IDK SRI+FP  +  FNL+YW+ +
Sbjct: 405 VKPSEEKTSESKKTYNS--------ISKIDKMSRIVFPVLFGTFNLVYWATY 448


>gi|34452723 gamma-aminobutyric acid A receptor, alpha 4 precursor
           [Homo sapiens]
          Length = 554

 Score =  233 bits (593), Expect = 4e-61
 Identities = 119/307 (38%), Positives = 184/307 (59%), Gaps = 6/307 (1%)

Query: 81  IDDHDFSMRPGFGGPAIPVGVDVQVESLDSISEVDMDFTMTLYLRHYWKDERLSFPSTNN 140
           +D +D  +RPGFGGP   V  D+ V S   +S+V+M++TM ++ R  W D+RL +     
Sbjct: 56  LDGYDNRLRPGFGGPVTEVKTDIYVTSFGPVSDVEMEYTMDVFFRQTWIDKRLKYDGPIE 115

Query: 141 LSMTFDGRLVKKIWVPDMFFVHSKRSFIHDTTTDNVMLRVQPDGKVLYSLRVTVTAMCNM 200
           + +  +  +V K+W PD FF + K+S  H+ T  N + R+  +G +LY++R+T++A C M
Sbjct: 116 I-LRLNNMMVTKVWTPDTFFRNGKKSVSHNMTAPNKLFRIMRNGTILYTMRLTISAECPM 174

Query: 201 DFSRFPLDTQTCSLEIESYAYTEDDLMLYWKKGNDSLKTDERISLSQFLIQEF---HTTT 257
               FP+D   C L+  SYAY + +++  W KG +  K+ E    S  L+Q      T +
Sbjct: 175 RLVDFPMDGHACPLKFGSYAYPKSEMIYTWTKGPE--KSVEVPKESSSLVQYDLIGQTVS 232

Query: 258 KLAFYSSTGWYNRLYINFTLRRHIFFFLLQTYFPATLMVMLSWVSFWIDRRAVPARVPLG 317
                S TG Y  + + F LRR + +F++QTY P  + V+LS VSFWI++ +VPAR   G
Sbjct: 233 SETIKSITGEYIVMTVYFHLRRKMGYFMIQTYIPCIMTVILSQVSFWINKESVPARTVFG 292

Query: 318 ITTVLTMSTIITGVNASMPRVSYIKAVDIYLWVSFVFVFLSVLEYAAVNYLTTVQERKEQ 377
           ITTVLTM+T+      S+P+VSY  A+D ++ V F FVF +++E+AAVNY T +Q  K +
Sbjct: 293 ITTVLTMTTLSISARHSLPKVSYATAMDWFIAVCFAFVFSALIEFAAVNYFTNIQMEKAK 352

Query: 378 KLREKLP 384
           +   K P
Sbjct: 353 RKTSKPP 359



 Score = 38.1 bits (87), Expect = 0.018
 Identities = 13/27 (48%), Positives = 20/27 (74%)

Query: 452 THAIDKYSRIIFPAAYILFNLIYWSIF 478
           T  IDKY+RI+FP  +  FN++YW ++
Sbjct: 515 TSKIDKYARILFPVTFGAFNMVYWVVY 541


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.323    0.136    0.420 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,618,590
Number of Sequences: 37866
Number of extensions: 764660
Number of successful extensions: 2744
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 61
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 2561
Number of HSP's gapped (non-prelim): 97
length of query: 479
length of database: 18,247,518
effective HSP length: 106
effective length of query: 373
effective length of database: 14,233,722
effective search space: 5309178306
effective search space used: 5309178306
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.5 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.