Search of human proteins with 194018492

Search of human proteins with 194018492

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|194018492 transmembrane protease, serine 11F [Homo sapiens]
         (438 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|194018492 transmembrane protease, serine 11F [Homo sapiens]        885   0.0  
gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo ...   355   6e-98
gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo ...   351   6e-97
gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]       349   2e-96
gi|40254871 transmembrane protease, serine 11E [Homo sapiens]         349   3e-96
gi|4758508 transmembrane protease, serine 11D [Homo sapiens]          333   1e-91
gi|187761337 transmembrane protease, serine 11B [Homo sapiens]        320   1e-87
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa...   208   7e-54
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa...   208   7e-54
gi|223942069 enterokinase precursor [Homo sapiens]                    195   6e-50
gi|33695155 hepsin [Homo sapiens]                                     195   8e-50
gi|4504481 hepsin [Homo sapiens]                                      195   8e-50
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap...   195   8e-50
gi|11415040 matriptase [Homo sapiens]                                 193   2e-49
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]             188   7e-48
gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sap...   187   2e-47
gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sa...   186   3e-47
gi|33667063 transmembrane protease, serine 9 [Homo sapiens]           186   5e-47
gi|148613878 acrosin precursor [Homo sapiens]                         185   8e-47
gi|4503627 coagulation factor XI precursor [Homo sapiens]             184   2e-46
gi|117956391 protease, serine, 33 [Homo sapiens]                      181   9e-46
gi|170932492 transmembrane protease, serine 5 [Homo sapiens]          181   1e-45
gi|222831592 transmembrane protease, serine 7 [Homo sapiens]          180   2e-45
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]           179   3e-45
gi|21614531 testisin isoform 2 [Homo sapiens]                         177   2e-44
gi|13994276 marapsin [Homo sapiens]                                   175   6e-44
gi|5803197 testisin isoform 1 [Homo sapiens]                          175   6e-44
gi|110815798 ovochymase 1 [Homo sapiens]                              173   2e-43
gi|116256363 transmembrane protease, serine 13 [Homo sapiens]         173   3e-43
gi|11545839 protease, serine, 22 [Homo sapiens]                       173   3e-43

>gi|194018492 transmembrane protease, serine 11F [Homo sapiens]
          Length = 438

 Score =  885 bits (2287), Expect = 0.0
 Identities = 438/438 (100%), Positives = 438/438 (100%)

Query: 1   MMYAPVEFSEAEFSRAEYQRKQQFWDSVRLALFTLAIVAIIGIAIGIVTHFVVEDDKSFY 60
           MMYAPVEFSEAEFSRAEYQRKQQFWDSVRLALFTLAIVAIIGIAIGIVTHFVVEDDKSFY
Sbjct: 1   MMYAPVEFSEAEFSRAEYQRKQQFWDSVRLALFTLAIVAIIGIAIGIVTHFVVEDDKSFY 60

Query: 61  YLASFKVTNIKYKENYGIRSSREFIERSHQIERMMSRIFRHSSVGGRFIKSHVIKLSPDE 120
           YLASFKVTNIKYKENYGIRSSREFIERSHQIERMMSRIFRHSSVGGRFIKSHVIKLSPDE
Sbjct: 61  YLASFKVTNIKYKENYGIRSSREFIERSHQIERMMSRIFRHSSVGGRFIKSHVIKLSPDE 120

Query: 121 QGVDILIVLIFRYPSTDSAEQIKKKIEKALYQSLKTKQLSLTINKPSFRLTPIDSKKMRN 180
           QGVDILIVLIFRYPSTDSAEQIKKKIEKALYQSLKTKQLSLTINKPSFRLTPIDSKKMRN
Sbjct: 121 QGVDILIVLIFRYPSTDSAEQIKKKIEKALYQSLKTKQLSLTINKPSFRLTPIDSKKMRN 180

Query: 181 LLNSRCGIRMTSSNMPLPASSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISN 240
           LLNSRCGIRMTSSNMPLPASSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISN
Sbjct: 181 LLNSRCGIRMTSSNMPLPASSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISN 240

Query: 241 TWLLTAAHCFWKNKDPTQWIATFGATITPPAVKRNVRKIILHENYHRETNENDIALVQLS 300
           TWLLTAAHCFWKNKDPTQWIATFGATITPPAVKRNVRKIILHENYHRETNENDIALVQLS
Sbjct: 241 TWLLTAAHCFWKNKDPTQWIATFGATITPPAVKRNVRKIILHENYHRETNENDIALVQLS 300

Query: 301 TGVEFSNIVQRVCLPDSSIKLPPKTSVFVTGFGSIVDDGPIQNTLRQARVETISTDVCNR 360
           TGVEFSNIVQRVCLPDSSIKLPPKTSVFVTGFGSIVDDGPIQNTLRQARVETISTDVCNR
Sbjct: 301 TGVEFSNIVQRVCLPDSSIKLPPKTSVFVTGFGSIVDDGPIQNTLRQARVETISTDVCNR 360

Query: 361 KDVYDGLITPGMLCAGFMEGKIDACKGDSGGPLVYDNHDIWYIVGIVSWGQSCALPKKPG 420
           KDVYDGLITPGMLCAGFMEGKIDACKGDSGGPLVYDNHDIWYIVGIVSWGQSCALPKKPG
Sbjct: 361 KDVYDGLITPGMLCAGFMEGKIDACKGDSGGPLVYDNHDIWYIVGIVSWGQSCALPKKPG 420

Query: 421 VYTRVTKYRDWIASKTGM 438
           VYTRVTKYRDWIASKTGM
Sbjct: 421 VYTRVTKYRDWIASKTGM 438


>gi|167466252 transmembrane protease, serine 11A isoform 2 [Homo
           sapiens]
          Length = 418

 Score =  355 bits (910), Expect = 6e-98
 Identities = 188/439 (42%), Positives = 268/439 (61%), Gaps = 22/439 (5%)

Query: 1   MMYAPVEFSEAEFSRAEYQRKQQFWDSVRLALFTLAIVAIIGIAIGIVTHFVVEDDKSFY 60
           MMY  V F           R  + W    L + +L +VA+    IG++ HF+V D K  Y
Sbjct: 1   MMYRTVGFGTRS-------RNLKPWMIAVLIVLSLTVVAV---TIGLLVHFLVFDQKKEY 50

Query: 61  YLASFKVTNIKYKENYGIRSSREFIERSHQIERMMSRIFRHSSVGGRFIKSHVIKLSPDE 120
           Y  SFK+ + +   N+G  ++ +  +     E ++  IF  S+    +IK+ V++L+P+E
Sbjct: 51  YHGSFKILDPQINNNFGQSNTYQLKDLRETTENLVDEIFIDSAWKKNYIKNQVVRLTPEE 110

Query: 121 QGVDILIVLIFRYPSTDSAEQIKKKIEKALYQSLKTKQLSLTINKPSFRLTPIDSKKMRN 180
            GV + ++++F++PST+     +KKI+  L Q ++  + +L IN  S ++  + S     
Sbjct: 111 DGVKVDVIMVFQFPSTEQRAVREKKIQSILNQKIRNLR-ALPINASSVQVNAMSSSTGEL 169

Query: 181 LLNSRCGIRMTSSNMPLPASSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISN 240
            + + CG R+   N+         RI  G   A +  WPWQASLQ   + HQCGA+LISN
Sbjct: 170 TVQASCGKRVVPLNV--------NRIASG-VIAPKAAWPWQASLQY-DNIHQCGATLISN 219

Query: 241 TWLLTAAHCFWKNKDPTQWIATFGATITPPAVKRNVRKIILHENYHRETNENDIALVQLS 300
           TWL+TAAHCF K K+P QW  +FG  I PP +KRNVR+ I+HE Y     E DIA+VQ+S
Sbjct: 220 TWLVTAAHCFQKYKNPHQWTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVVQVS 279

Query: 301 TGVEFSNIVQRVCLPDSSIKLPPKTSVFVTGFGSIVDDGPIQNTLRQARVETISTDVCNR 360
           + V FS+ ++++CLP++S    P  +V +TGFG++   G  QN LR+ARV+ IS DVC +
Sbjct: 280 SRVTFSDDIRQICLPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDVCKQ 339

Query: 361 KDVYDGLITPGMLCAGFMEGKIDACKGDSGGPLV-YDNHDIWYIVGIVSWGQSCALPKKP 419
             VY   I PGM CAG+MEG  DAC+GDSGGPLV  D  D WY++GIVSWG +C    KP
Sbjct: 340 PQVYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQKDKP 399

Query: 420 GVYTRVTKYRDWIASKTGM 438
           GVYT+VT YR+WIASKTG+
Sbjct: 400 GVYTQVTYYRNWIASKTGI 418


>gi|167466250 transmembrane protease, serine 11A isoform 1 [Homo
           sapiens]
          Length = 421

 Score =  351 bits (901), Expect = 6e-97
 Identities = 189/442 (42%), Positives = 270/442 (61%), Gaps = 25/442 (5%)

Query: 1   MMYAPVEFSEAEFSRAEYQRKQQFWDSVRLALFTLAIVAIIGIAIGIVTHFVVEDDKSFY 60
           MMY  V F           R  + W    L + +L +VA+    IG++ HF+V D K  Y
Sbjct: 1   MMYRTVGFGTRS-------RNLKPWMIAVLIVLSLTVVAV---TIGLLVHFLVFDQKKEY 50

Query: 61  YLASFKVTNIKYKENYGIRSSREFIERSHQIERMMSR---IFRHSSVGGRFIKSHVIKLS 117
           Y  SFK+ + +   N+G  ++ +  +     E ++S+   IF  S+    +IK+ V++L+
Sbjct: 51  YHGSFKILDPQINNNFGQSNTYQLKDLRETTENLVSQVDEIFIDSAWKKNYIKNQVVRLT 110

Query: 118 PDEQGVDILIVLIFRYPSTDSAEQIKKKIEKALYQSLKTKQLSLTINKPSFRLTPIDSKK 177
           P+E GV + ++++F++PST+     +KKI+  L Q ++  + +L IN  S ++  + S  
Sbjct: 111 PEEDGVKVDVIMVFQFPSTEQRAVREKKIQSILNQKIRNLR-ALPINASSVQVNAMSSST 169

Query: 178 MRNLLNSRCGIRMTSSNMPLPASSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASL 237
               + + CG R+   N+         RI  G   A +  WPWQASLQ   + HQCGA+L
Sbjct: 170 GELTVQASCGKRVVPLNV--------NRIASG-VIAPKAAWPWQASLQY-DNIHQCGATL 219

Query: 238 ISNTWLLTAAHCFWKNKDPTQWIATFGATITPPAVKRNVRKIILHENYHRETNENDIALV 297
           ISNTWL+TAAHCF K K+P QW  +FG  I PP +KRNVR+ I+HE Y     E DIA+V
Sbjct: 220 ISNTWLVTAAHCFQKYKNPHQWTVSFGTKINPPLMKRNVRRFIIHEKYRSAAREYDIAVV 279

Query: 298 QLSTGVEFSNIVQRVCLPDSSIKLPPKTSVFVTGFGSIVDDGPIQNTLRQARVETISTDV 357
           Q+S+ V FS+ ++++CLP++S    P  +V +TGFG++   G  QN LR+ARV+ IS DV
Sbjct: 280 QVSSRVTFSDDIRQICLPEASASFQPNLTVHITGFGALYYGGESQNDLREARVKIISDDV 339

Query: 358 CNRKDVYDGLITPGMLCAGFMEGKIDACKGDSGGPLV-YDNHDIWYIVGIVSWGQSCALP 416
           C +  VY   I PGM CAG+MEG  DAC+GDSGGPLV  D  D WY++GIVSWG +C   
Sbjct: 340 CKQPQVYGNDIKPGMFCAGYMEGIYDACRGDSGGPLVTRDLKDTWYLIGIVSWGDNCGQK 399

Query: 417 KKPGVYTRVTKYRDWIASKTGM 438
            KPGVYT+VT YR+WIASKTG+
Sbjct: 400 DKPGVYTQVTYYRNWIASKTGI 421


>gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]
          Length = 423

 Score =  349 bits (896), Expect = 2e-96
 Identities = 184/421 (43%), Positives = 256/421 (60%), Gaps = 10/421 (2%)

Query: 20  RKQQFWDSVRLALFTLAIVAIIGIAIGIVTHFVVEDDKSFY-YLASFKVTNIKYKENYGI 78
           RK+  W+   + L     + ++ + IG+  H+V  + K  Y Y ++   T  K    +G 
Sbjct: 11  RKRVCWEPWVIGLVIFISLIVLAVCIGLTVHYVRYNQKKTYNYYSTLSFTTDKLYAEFGR 70

Query: 79  RSSREFIERSHQIERMMSRIFRHSSVGGRFIKSHVIKLSPDEQGVDILIVLIFRYPSTDS 138
            +S  F E S ++E M+   F  S +   F+KS VIK S  + GV   ++LI R+ ST+ 
Sbjct: 71  EASNNFTEMSQRLESMVKNAFYKSPLREEFVKSQVIKFSQQKHGVLAHMLLICRFHSTED 130

Query: 139 AEQIKKKIEKALYQSLKTKQLSLTINKPSFRLTPIDSKKMRNLLNSRCGIRMTSSNMPLP 198
            E + K ++  L++ L+       ++  S ++  I+  +  + LN  CG R + +     
Sbjct: 131 PETVDKIVQLVLHEKLQDAVGPPKVDPQSVKIKKINKTETDSYLNHCCGTRRSKT----- 185

Query: 199 ASSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDPTQ 258
               + RIV G E   EGEWPWQASLQ  GS H+CGA+LI+ TWL++AAHCF   K+P +
Sbjct: 186 -LGQSLRIVGGTEVE-EGEWPWQASLQWDGS-HRCGATLINATWLVSAAHCFTTYKNPAR 242

Query: 259 WIATFGATITPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCLPDSS 318
           W A+FG TI P  +KR +R+II+HE Y   +++ DI+L +LS+ V ++N V RVCLPD+S
Sbjct: 243 WTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPDAS 302

Query: 319 IKLPPKTSVFVTGFGSIVDDGPIQNTLRQARVETISTDVCNRKDVYDGLITPGMLCAGFM 378
            +  P   +FVTGFG++ +DG  QN LRQA+V  I    CN    Y+  ITP MLCAG +
Sbjct: 303 YEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAGSL 362

Query: 379 EGKIDACKGDSGGPLV-YDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDWIASKTG 437
           EGK DAC+GDSGGPLV  D  DIWY+ GIVSWG  CA P KPGVYTRVT  RDWI SKTG
Sbjct: 363 EGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSKTG 422

Query: 438 M 438
           +
Sbjct: 423 I 423


>gi|40254871 transmembrane protease, serine 11E [Homo sapiens]
          Length = 423

 Score =  349 bits (895), Expect = 3e-96
 Identities = 184/421 (43%), Positives = 256/421 (60%), Gaps = 10/421 (2%)

Query: 20  RKQQFWDSVRLALFTLAIVAIIGIAIGIVTHFVVEDDKSFY-YLASFKVTNIKYKENYGI 78
           RK+  W+   + L     + ++ + IG+  H+V  + K  Y Y ++   T  K    +G 
Sbjct: 11  RKRVCWEPWVIGLVIFISLIVLAVCIGLTVHYVRYNQKKTYNYYSTLSFTTDKLYAEFGR 70

Query: 79  RSSREFIERSHQIERMMSRIFRHSSVGGRFIKSHVIKLSPDEQGVDILIVLIFRYPSTDS 138
            +S  F E S ++E M+   F  S +   F+KS VIK S  + GV   ++LI R+ ST+ 
Sbjct: 71  EASNNFTEMSQRLESMVKNAFYKSPLREEFVKSQVIKFSQQKHGVLAHMLLICRFHSTED 130

Query: 139 AEQIKKKIEKALYQSLKTKQLSLTINKPSFRLTPIDSKKMRNLLNSRCGIRMTSSNMPLP 198
            E + K ++  L++ L+       ++  S ++  I+  +  + LN  CG R + +     
Sbjct: 131 PETVDKIVQLVLHEKLQDAVGPPKVDPHSVKIKKINKTETDSYLNHCCGTRRSKT----- 185

Query: 199 ASSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDPTQ 258
               + RIV G E   EGEWPWQASLQ  GS H+CGA+LI+ TWL++AAHCF   K+P +
Sbjct: 186 -LGQSLRIVGGTEVE-EGEWPWQASLQWDGS-HRCGATLINATWLVSAAHCFTTYKNPAR 242

Query: 259 WIATFGATITPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCLPDSS 318
           W A+FG TI P  +KR +R+II+HE Y   +++ DI+L +LS+ V ++N V RVCLPD+S
Sbjct: 243 WTASFGVTIKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPDAS 302

Query: 319 IKLPPKTSVFVTGFGSIVDDGPIQNTLRQARVETISTDVCNRKDVYDGLITPGMLCAGFM 378
            +  P   +FVTGFG++ +DG  QN LRQA+V  I    CN    Y+  ITP MLCAG +
Sbjct: 303 YEFQPGDVMFVTGFGALKNDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAGSL 362

Query: 379 EGKIDACKGDSGGPLV-YDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDWIASKTG 437
           EGK DAC+GDSGGPLV  D  DIWY+ GIVSWG  CA P KPGVYTRVT  RDWI SKTG
Sbjct: 363 EGKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWITSKTG 422

Query: 438 M 438
           +
Sbjct: 423 I 423


>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
          Length = 418

 Score =  333 bits (855), Expect = 1e-91
 Identities = 175/417 (41%), Positives = 254/417 (60%), Gaps = 11/417 (2%)

Query: 23  QFWDSVRLALFTLAIVAIIGIAIGIVTHFVVEDDKSFYYLASFKVTNIKYKENYGIRSSR 82
           +F +   +    +A V I+ + I ++ +F+  D KS++Y +SF++ N++Y       +++
Sbjct: 12  RFLNPYVVCFIVVAGVVILAVTIALLVYFLAFDQKSYFYRSSFQLLNVEYNSQLNSPATQ 71

Query: 83  EFIERSHQIERMMSRIFRHSSVGGRFIKSHVIKLSPDEQGVDILIVLIFRYPSTDSAEQI 142
           E+   S +IE ++++ F+ S++  +FI++HV KL  D  GV   +V+ F++   ++   +
Sbjct: 72  EYRTLSGRIESLITKTFKESNLRNQFIRAHVAKLRQDGSGVRADVVMKFQFTRNNNGASM 131

Query: 143 KKKIEKALYQSLKTKQLSLTINKPSFRLTPIDSKKMRNLLNSRCGIRMTSSNMPLPASSS 202
           K +IE  L Q L     +L IN PS  +T +  +   N L + CG        P   + S
Sbjct: 132 KSRIESVLRQMLNNSG-NLEIN-PSTEITSLTDQAAANWLINECGAG------PDLITLS 183

Query: 203 TQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDPTQWIAT 262
            QRI+ G E A EG WPWQ SL+L  + H CG SLI+N W+LTAAHCF  N +P  WIAT
Sbjct: 184 EQRILGGTE-AEEGSWPWQVSLRL-NNAHHCGGSLINNMWILTAAHCFRSNSNPRDWIAT 241

Query: 263 FGATITPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCLPDSSIKLP 322
            G + T P ++  VR I++H NY   T+ENDIALV+L   V F+  +  VCLP ++  +P
Sbjct: 242 SGISTTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFTKDIHSVCLPAATQNIP 301

Query: 323 PKTSVFVTGFGSIVDDGPIQNTLRQARVETISTDVCNRKDVYDGLITPGMLCAGFMEGKI 382
           P ++ +VTG+G+    G     LRQ +V  IS DVCN    Y+G I  GMLCAG  +G +
Sbjct: 302 PGSTAYVTGWGAQEYAGHTVPELRQGQVRIISNDVCNAPHSYNGAILSGMLCAGVPQGGV 361

Query: 383 DACKGDSGGPLVY-DNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDWIASKTGM 438
           DAC+GDSGGPLV  D+  +W+IVGIVSWG  C LP KPGVYTRVT Y DWI  +TG+
Sbjct: 362 DACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYTRVTAYLDWIRQQTGI 418


>gi|187761337 transmembrane protease, serine 11B [Homo sapiens]
          Length = 416

 Score =  320 bits (821), Expect = 1e-87
 Identities = 166/421 (39%), Positives = 247/421 (58%), Gaps = 14/421 (3%)

Query: 19  QRKQQFWDSVRLALFTLAIVAIIGIAIGIVTHFVVEDDKSFYYLASFKVTNIKYKENYGI 78
           QR    W ++      L + AI+G+ IG++ HF+  + K++YY   F ++ + Y +N   
Sbjct: 9   QRSWPLWTTI---FIFLGVAAILGVTIGLLVHFLAVE-KTYYYQGDFHISGVTYNDNCEN 64

Query: 79  RSSREFIERSHQIERMMSRIFRHSSVGGRFIKSHVIKLSPDEQGVDILIVLIFRYPSTDS 138
            +S+     S  IE  M   F++SS+   ++KS VIKL P+  G ++ + L F++P  + 
Sbjct: 65  AASQASTNLSKDIETKMLNAFQNSSIYKEYVKSEVIKLLPNANGSNVQLQLKFKFPPAEG 124

Query: 139 AEQIKKKIEKALYQSLKTKQLSLTINKPSFRLTPIDSKKMRNLLNSRCGIRMTSSNMPLP 198
              ++ KI+  L+Q LK    S      S +L  I       L N+ CG ++ +S +   
Sbjct: 125 VS-MRTKIKAKLHQMLKNNMASWNAVPASIKLMEISKAASEMLTNNCCGRQVANSII--- 180

Query: 199 ASSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDPTQ 258
              +  +IV G+ +++EG WPWQAS+Q  G  H CGASLIS+ WLL+AAHCF K  +   
Sbjct: 181 ---TGNKIVNGK-SSLEGAWPWQASMQWKGR-HYCGASLISSRWLLSAAHCFAKKNNSKD 235

Query: 259 WIATFGATITPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCLPDSS 318
           W   FG  +  P + R V+ II HENY      +DIALVQL+  V F+  ++++CLP++ 
Sbjct: 236 WTVNFGIVVNKPYMTRKVQNIIFHENYSSPGLHDDIALVQLAEEVSFTEYIRKICLPEAK 295

Query: 319 IKLPPKTSVFVTGFGSIVDDGPIQNTLRQARVETISTDVCNRKDVYDGLITPGMLCAGFM 378
           +KL    +V VTG+G++  +G     L++  ++ I   +CN    Y G +T  MLCAGFM
Sbjct: 296 MKLSENDNVVVTGWGTLYMNGSFPVILQEDFLKIIDNKICNASYAYSGFVTDTMLCAGFM 355

Query: 379 EGKIDACKGDSGGPLVY-DNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDWIASKTG 437
            G+ DAC+ DSGGPL Y D+ +IW++VGIVSWG  C    KPGVYTRVT YR+WI SKTG
Sbjct: 356 SGEADACQNDSGGPLAYPDSRNIWHLVGIVSWGDGCGKKNKPGVYTRVTSYRNWITSKTG 415

Query: 438 M 438
           +
Sbjct: 416 L 416


>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
           sapiens]
          Length = 529

 Score =  208 bits (530), Expect = 7e-54
 Identities = 110/286 (38%), Positives = 161/286 (56%), Gaps = 14/286 (4%)

Query: 151 YQSLKTKQLSLTINKPSFRLTPIDSKKMRNLLNSRCGIRMTSSNMPLPASSSTQRIVQGR 210
           +  L T   ++ I K  +      SK + +L    CG+ + SS           RIV G 
Sbjct: 246 FMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQ--------SRIVGG- 296

Query: 211 ETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKN-KDPTQWIATFGA---T 266
           E+A+ G WPWQ SL  + + H CG S+I+  W++TAAHC  K   +P  W A  G    +
Sbjct: 297 ESALPGAWPWQVSLH-VQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQS 355

Query: 267 ITPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCLPDSSIKLPPKTS 326
                    V K+I H NY  +T  NDIAL++L   + F+++V+ VCLP+  + L P+  
Sbjct: 356 FMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQL 415

Query: 327 VFVTGFGSIVDDGPIQNTLRQARVETISTDVCNRKDVYDGLITPGMLCAGFMEGKIDACK 386
            +++G+G+  + G     L  A+V  I T  CN + VYD LITP M+CAGF++G +D+C+
Sbjct: 416 CWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQ 475

Query: 387 GDSGGPLVYDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDWI 432
           GDSGGPLV   ++IW+++G  SWG  CA   +PGVY  V  + DWI
Sbjct: 476 GDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWI 521


>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
           sapiens]
          Length = 492

 Score =  208 bits (530), Expect = 7e-54
 Identities = 110/286 (38%), Positives = 161/286 (56%), Gaps = 14/286 (4%)

Query: 151 YQSLKTKQLSLTINKPSFRLTPIDSKKMRNLLNSRCGIRMTSSNMPLPASSSTQRIVQGR 210
           +  L T   ++ I K  +      SK + +L    CG+ + SS           RIV G 
Sbjct: 209 FMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQ--------SRIVGG- 259

Query: 211 ETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKN-KDPTQWIATFGA---T 266
           E+A+ G WPWQ SL  + + H CG S+I+  W++TAAHC  K   +P  W A  G    +
Sbjct: 260 ESALPGAWPWQVSLH-VQNVHVCGGSIITPEWIVTAAHCVEKPLNNPWHWTAFAGILRQS 318

Query: 267 ITPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCLPDSSIKLPPKTS 326
                    V K+I H NY  +T  NDIAL++L   + F+++V+ VCLP+  + L P+  
Sbjct: 319 FMFYGAGYQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQL 378

Query: 327 VFVTGFGSIVDDGPIQNTLRQARVETISTDVCNRKDVYDGLITPGMLCAGFMEGKIDACK 386
            +++G+G+  + G     L  A+V  I T  CN + VYD LITP M+CAGF++G +D+C+
Sbjct: 379 CWISGWGATEEKGKTSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQ 438

Query: 387 GDSGGPLVYDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDWI 432
           GDSGGPLV   ++IW+++G  SWG  CA   +PGVY  V  + DWI
Sbjct: 439 GDSGGPLVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWI 484


>gi|223942069 enterokinase precursor [Homo sapiens]
          Length = 1019

 Score =  195 bits (496), Expect = 6e-50
 Identities = 100/271 (36%), Positives = 162/271 (59%), Gaps = 11/271 (4%)

Query: 170  LTPIDSKKMRNLLNSRCGIRMTSSNMPLPASSSTQRIVQGRETAMEGEWPWQASLQLIGS 229
            LTP       +L+  +C  +  S    L A   T +IV G   A EG WPW   L   G 
Sbjct: 751  LTPSQQCLQDSLIRLQCNHK--SCGKKLAAQDITPKIVGG-SNAKEGAWPWVVGLYY-GG 806

Query: 230  GHQCGASLISNTWLLTAAHCFW-KNKDPTQWIATFGATI-----TPPAVKRNVRKIILHE 283
               CGASL+S+ WL++AAHC + +N +P++W A  G  +     +P  V R + +I+++ 
Sbjct: 807  RLLCGASLVSSDWLVSAAHCVYGRNLEPSKWTAILGLHMKSNLTSPQTVPRLIDEIVINP 866

Query: 284  NYHRETNENDIALVQLSTGVEFSNIVQRVCLPDSSIKLPPKTSVFVTGFGSIVDDGPIQN 343
            +Y+R   +NDIA++ L   V +++ +Q +CLP+ +   PP  +  + G+G++V  G   N
Sbjct: 867  HYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGTTAN 926

Query: 344  TLRQARVETISTDVCNRKDVYDGLITPGMLCAGFMEGKIDACKGDSGGPLVYDNHDIWYI 403
             L++A V  +S + C ++ + +  IT  M+CAG+ EG ID+C+GDSGGPL+   ++ W++
Sbjct: 927  ILQEADVPLLSNERCQQQ-MPEYNITENMICAGYEEGGIDSCQGDSGGPLMCQENNRWFL 985

Query: 404  VGIVSWGQSCALPKKPGVYTRVTKYRDWIAS 434
             G+ S+G  CALP +PGVY RV+++ +WI S
Sbjct: 986  AGVTSFGYKCALPNRPGVYARVSRFTEWIQS 1016


>gi|33695155 hepsin [Homo sapiens]
          Length = 417

 Score =  195 bits (495), Expect = 8e-50
 Identities = 108/241 (44%), Positives = 145/241 (60%), Gaps = 15/241 (6%)

Query: 205 RIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCF-WKNKDPTQWIATF 263
           RIV GR+T++ G WPWQ SL+  G+ H CG SL+S  W+LTAAHCF  +N+  ++W    
Sbjct: 162 RIVGGRDTSL-GRWPWQVSLRYDGA-HLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFA 219

Query: 264 GATI--TPPAVKRNVRKIILHENY------HRETNENDIALVQLSTGVEFSNIVQRVCLP 315
           GA    +P  ++  V+ ++ H  Y      + E N NDIALV LS+ +  +  +Q VCLP
Sbjct: 220 GAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLP 279

Query: 316 DSSIKLPPKTSVFVTGFGSIVDDGPIQNTLRQARVETISTDVCNRKDVYDGLITPGMLCA 375
            +   L       VTG+G+    G     L++ARV  IS DVCN  D Y   I P M CA
Sbjct: 280 AAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCA 339

Query: 376 GFMEGKIDACKGDSGGPLVYDNH----DIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDW 431
           G+ EG IDAC+GDSGGP V ++       W + GIVSWG  CAL +KPGVYT+V+ +R+W
Sbjct: 340 GYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREW 399

Query: 432 I 432
           I
Sbjct: 400 I 400


>gi|4504481 hepsin [Homo sapiens]
          Length = 417

 Score =  195 bits (495), Expect = 8e-50
 Identities = 108/241 (44%), Positives = 145/241 (60%), Gaps = 15/241 (6%)

Query: 205 RIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCF-WKNKDPTQWIATF 263
           RIV GR+T++ G WPWQ SL+  G+ H CG SL+S  W+LTAAHCF  +N+  ++W    
Sbjct: 162 RIVGGRDTSL-GRWPWQVSLRYDGA-HLCGGSLLSGDWVLTAAHCFPERNRVLSRWRVFA 219

Query: 264 GATI--TPPAVKRNVRKIILHENY------HRETNENDIALVQLSTGVEFSNIVQRVCLP 315
           GA    +P  ++  V+ ++ H  Y      + E N NDIALV LS+ +  +  +Q VCLP
Sbjct: 220 GAVAQASPHGLQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLP 279

Query: 316 DSSIKLPPKTSVFVTGFGSIVDDGPIQNTLRQARVETISTDVCNRKDVYDGLITPGMLCA 375
            +   L       VTG+G+    G     L++ARV  IS DVCN  D Y   I P M CA
Sbjct: 280 AAGQALVDGKICTVTGWGNTQYYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCA 339

Query: 376 GFMEGKIDACKGDSGGPLVYDNH----DIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDW 431
           G+ EG IDAC+GDSGGP V ++       W + GIVSWG  CAL +KPGVYT+V+ +R+W
Sbjct: 340 GYPEGGIDACQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREW 399

Query: 432 I 432
           I
Sbjct: 400 I 400


>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
           sapiens]
          Length = 454

 Score =  195 bits (495), Expect = 8e-50
 Identities = 100/233 (42%), Positives = 138/233 (59%), Gaps = 5/233 (2%)

Query: 203 TQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDPTQWIAT 262
           + RIV G  + +  +WPWQASLQ  G  H CG S+I+  W++TAAHC +    P  W   
Sbjct: 214 SSRIVGGNMSLLS-QWPWQASLQFQGY-HLCGGSVITPLWIITAAHCVYDLYLPKSWTIQ 271

Query: 263 FG--ATITPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCLPDSSIK 320
            G  + +  PA    V KI+ H  Y  +   NDIAL++L+  + F+ ++Q VCLP+S   
Sbjct: 272 VGLVSLLDNPAPSHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEEN 331

Query: 321 LPPKTSVFVTGFGSIVDD-GPIQNTLRQARVETISTDVCNRKDVYDGLITPGMLCAGFME 379
            P     + +G+G+  D  G     L  A V  IS  +CN +DVY G+I+P MLCAG++ 
Sbjct: 332 FPDGKVCWTSGWGATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLT 391

Query: 380 GKIDACKGDSGGPLVYDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDWI 432
           G +D+C+GDSGGPLV     +W +VG  S+G  CA   KPGVYTRVT + DWI
Sbjct: 392 GGVDSCQGDSGGPLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWI 444


>gi|11415040 matriptase [Homo sapiens]
          Length = 855

 Score =  193 bits (491), Expect = 2e-49
 Identities = 106/264 (40%), Positives = 150/264 (56%), Gaps = 23/264 (8%)

Query: 186 CGIRMTSSNMPLPASSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLT 245
           CG+R          S + Q  V G   A EGEWPWQ SL  +G GH CGASLIS  WL++
Sbjct: 604 CGLR----------SFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLISPNWLVS 653

Query: 246 AAHCF-----WKNKDPTQWIATFG-----ATITPPAVKRNVRKIILHENYHRETNENDIA 295
           AAHC+     ++  DPTQW A  G         P   +R +++II H  ++  T + DIA
Sbjct: 654 AAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFTFDYDIA 713

Query: 296 LVQLSTGVEFSNIVQRVCLPDSSIKLPPKTSVFVTGFGSIVDDGPIQNTLRQARVETIST 355
           L++L    E+S++V+ +CLPD+S   P   +++VTG+G     G     L++  +  I+ 
Sbjct: 714 LLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGTGALILQKGEIRVINQ 773

Query: 356 DVCNRKDVYDGLITPGMLCAGFMEGKIDACKGDSGGPLVYDNHD-IWYIVGIVSWGQSCA 414
             C  +++    ITP M+C GF+ G +D+C+GDSGGPL     D   +  G+VSWG  CA
Sbjct: 774 TTC--ENLLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQAGVVSWGDGCA 831

Query: 415 LPKKPGVYTRVTKYRDWIASKTGM 438
              KPGVYTR+  +RDWI   TG+
Sbjct: 832 QRNKPGVYTRLPLFRDWIKENTGV 855


>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
          Length = 638

 Score =  188 bits (478), Expect = 7e-48
 Identities = 103/252 (40%), Positives = 144/252 (57%), Gaps = 9/252 (3%)

Query: 191 TSSNMPLPASSSTQRIVQGRETAMEGEWPWQASLQ--LIGSGHQCGASLISNTWLLTAAH 248
           T  N      +ST RIV G  ++  GEWPWQ SLQ  L    H CG SLI + W+LTAAH
Sbjct: 377 TGDNSVCTTKTST-RIVGGTNSSW-GEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAH 434

Query: 249 CFWKNKDPTQWIATFG----ATITPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVE 304
           CF        W    G    + IT       +++II+H+NY      +DIAL++L   + 
Sbjct: 435 CFDGLPLQDVWRIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLN 494

Query: 305 FSNIVQRVCLPDSSIKLPPKTSVFVTGFGSIVDDGPIQNTLRQARVETISTDVCNRKDVY 364
           ++   + +CLP         T+ +VTG+G   + G IQN L++  +  ++ + C +K   
Sbjct: 495 YTEFQKPICLPSKGDTSTIYTNCWVTGWGFSKEKGEIQNILQKVNIPLVTNEEC-QKRYQ 553

Query: 365 DGLITPGMLCAGFMEGKIDACKGDSGGPLVYDNHDIWYIVGIVSWGQSCALPKKPGVYTR 424
           D  IT  M+CAG+ EG  DACKGDSGGPLV  ++ +W +VGI SWG+ CA  ++PGVYT+
Sbjct: 554 DYKITQRMVCAGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTK 613

Query: 425 VTKYRDWIASKT 436
           V +Y DWI  KT
Sbjct: 614 VAEYMDWILEKT 625


>gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo
           sapiens]
          Length = 437

 Score =  187 bits (475), Expect = 2e-47
 Identities = 107/286 (37%), Positives = 155/286 (54%), Gaps = 20/286 (6%)

Query: 164 NKPSFR---LTPIDSKKMRNLLNSRCGIRMTSSNMPLPASS-------------STQRIV 207
           +KP+FR   + P     +  +  +   +RM +S+ P  + S              T R+V
Sbjct: 147 SKPTFRAVEIGPDQDLDVVEITENSQELRMRNSSGPCLSGSLVSLHCLACGKSLKTPRVV 206

Query: 208 QGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDPTQWIATFGATI 267
            G E +++  WPWQ S+Q     H CG S++   W+LTAAHCF K+ D   W    G+  
Sbjct: 207 GGEEASVDS-WPWQVSIQY-DKQHVCGGSILDPHWVLTAAHCFRKHTDVFNWKVRAGSDK 264

Query: 268 TPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCLPDSSIKLPPKTSV 327
                   V KII+ E       +NDIAL++L   + FS  V+ +CLP    +L P T +
Sbjct: 265 LGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDEELTPATPL 324

Query: 328 FVTGFGSIVDDG-PIQNTLRQARVETISTDVCNRKDVYDGLITPGMLCAGFMEGKIDACK 386
           ++ G+G    +G  + + L QA V+ I +  CN  D Y G +T  M+CAG  EG +D C+
Sbjct: 325 WIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIPEGGVDTCQ 384

Query: 387 GDSGGPLVYDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDWI 432
           GDSGGPL+Y + D W++VGIVSWG  C  P  PGVYT+V+ Y +WI
Sbjct: 385 GDSGGPLMYQS-DQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 429


>gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo
           sapiens]
          Length = 432

 Score =  186 bits (473), Expect = 3e-47
 Identities = 98/234 (41%), Positives = 136/234 (58%), Gaps = 4/234 (1%)

Query: 200 SSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDPTQW 259
           S  T R+V G E +++  WPWQ S+Q     H CG S++   W+LTAAHCF K+ D   W
Sbjct: 194 SLKTPRVVGGEEASVDS-WPWQVSIQY-DKQHVCGGSILDPHWVLTAAHCFRKHTDVFNW 251

Query: 260 IATFGATITPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCLPDSSI 319
               G+          V KII+ E       +NDIAL++L   + FS  V+ +CLP    
Sbjct: 252 KVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDNDIALMKLQFPLTFSGTVRPICLPFFDE 311

Query: 320 KLPPKTSVFVTGFGSIVDDG-PIQNTLRQARVETISTDVCNRKDVYDGLITPGMLCAGFM 378
           +L P T +++ G+G    +G  + + L QA V+ I +  CN  D Y G +T  M+CAG  
Sbjct: 312 ELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVTEKMMCAGIP 371

Query: 379 EGKIDACKGDSGGPLVYDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDWI 432
           EG +D C+GDSGGPL+Y + D W++VGIVSWG  C  P  PGVYT+V+ Y +WI
Sbjct: 372 EGGVDTCQGDSGGPLMYQS-DQWHVVGIVSWGYGCGGPSTPGVYTKVSAYLNWI 424


>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
          Length = 1059

 Score =  186 bits (471), Expect = 5e-47
 Identities = 99/245 (40%), Positives = 153/245 (62%), Gaps = 10/245 (4%)

Query: 198 PASSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDPT 257
           PA     RIV G E A  GE+PWQASL+     H CGA++I+  WL++AAHCF + +DPT
Sbjct: 195 PAWRMAGRIVGGME-ASPGEFPWQASLRE-NKEHFCGAAIINARWLVSAAHCFNEFQDPT 252

Query: 258 QWIATFGATI----TPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVC 313
           +W+A  GAT         V+  V +I+ H  Y+ +T + D+A+++L++ + F   +Q VC
Sbjct: 253 KWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRHIQPVC 312

Query: 314 LPDSSIKLPPKTSVFVTGFGSIVDDGPIQ-NTLRQARVETISTDVCNRKDVYDGLITPGM 372
           LP ++   PP     ++G+G + +D  ++   L++A VE +   +C    +Y   +T  M
Sbjct: 313 LPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALC--ASLYGHSLTDRM 370

Query: 373 LCAGFMEGKIDACKGDSGGPLVYDN-HDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDW 431
           +CAG+++GK+D+C+GDSGGPLV +     +++ GIVSWG  CA  ++PGVY RVT+ RDW
Sbjct: 371 VCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVTRLRDW 430

Query: 432 IASKT 436
           I   T
Sbjct: 431 ILEAT 435



 Score =  178 bits (452), Expect = 8e-45
 Identities = 97/237 (40%), Positives = 133/237 (56%), Gaps = 6/237 (2%)

Query: 199  ASSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDPTQ 258
            A ++  RIV G   A  GEWPWQ SL L    H+CGA L++  WLL+AAHCF    DP Q
Sbjct: 820  APAALTRIVGG-SAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGDPKQ 878

Query: 259  WIATFGATITPPAVKR--NVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCLPD 316
            W A  G      A  +   V +I  H  Y+  T + D+AL++L+  V  S +V+ +CLP+
Sbjct: 879  WAAFLGTPFLSGAEGQLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVRPICLPE 938

Query: 317  SSIKLPPKTSVFVTGFGSIVDDGPIQNTLRQARVETISTDVCNRKDVYDGLITPGMLCAG 376
             + + P  T   +TG+GS+ + G +   L++A V  +S   C R   Y   I+  MLCAG
Sbjct: 939  PAPRPPDGTRCVITGWGSVREGGSMARQLQKAAVRLLSEQTCRR--FYPVQISSRMLCAG 996

Query: 377  FMEGKIDACKGDSGGPLV-YDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDWI 432
            F +G +D+C GD+GGPL   +    W + G+ SWG  C  P  PGVYTRV   R WI
Sbjct: 997  FPQGGVDSCSGDAGGPLACREPSGRWVLTGVTSWGYGCGRPHFPGVYTRVAAVRGWI 1053



 Score =  162 bits (411), Expect = 4e-40
 Identities = 94/241 (39%), Positives = 142/241 (58%), Gaps = 11/241 (4%)

Query: 198 PASSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDPT 257
           PA     R+V G   A  GE PWQ SL+  GS H CGA+++ + WLL+AAHCF   K   
Sbjct: 496 PAMEKPTRVVGGFGAA-SGEVPWQVSLKE-GSRHFCGATVVGDRWLLSAAHCFNHTK-VE 552

Query: 258 QWIATFGAT----ITPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVC 313
           Q  A  G      +    VK  +R+++LH  Y+    + D+A+++L++ + F+  +Q VC
Sbjct: 553 QVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAFNKYIQPVC 612

Query: 314 LPDSSIKLPPKTSVFVTGFGSIVDDGPIQ-NTLRQARVETISTDVCNRKDVYDGLITPGM 372
           LP +  K P      ++G+G+  +    +   L++A V  I    C+   +Y+  +T  M
Sbjct: 613 LPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTCSV--LYNFSLTDRM 670

Query: 373 LCAGFMEGKIDACKGDSGGPLVYDNHD-IWYIVGIVSWGQSCALPKKPGVYTRVTKYRDW 431
           +CAGF+EGK+D+C+GDSGGPL  +    ++Y+ GIVSWG  CA  KKPGVYTR+T+ + W
Sbjct: 671 ICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYTRITRLKGW 730

Query: 432 I 432
           I
Sbjct: 731 I 731


>gi|148613878 acrosin precursor [Homo sapiens]
          Length = 421

 Score =  185 bits (469), Expect = 8e-47
 Identities = 102/250 (40%), Positives = 138/250 (55%), Gaps = 18/250 (7%)

Query: 205 RIVQGRETAMEGEWPWQASLQLIGSG----HQCGASLISNTWLLTAAHCFWKNKDPTQWI 260
           RIV G+  A  G WPW  SLQ+        H CG SL+++ W+LTAAHCF    +   W 
Sbjct: 42  RIVGGK-AAQHGAWPWMVSLQIFTYNSHRYHTCGGSLLNSRWVLTAAHCFVGKNNVHDWR 100

Query: 261 ATFGAT---------ITPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQR 311
             FGA          +  P  +R V KII+HE Y+  T  NDIALV+++  +     +  
Sbjct: 101 LVFGAKEITYGNNKPVKAPLQERYVEKIIIHEKYNSATEGNDIALVEITPPISCGRFIGP 160

Query: 312 VCLPDSSIKLPPKT-SVFVTGFGSIVDDGPIQNT-LRQARVETISTDVCNRKDVYDGLIT 369
            CLP     LP  + S +V G+G I +  P  ++ L +ARV+ I  D+CN    Y+G + 
Sbjct: 161 GCLPHFKAGLPRGSQSCWVAGWGYIEEKAPRPSSILMEARVDLIDLDLCNSTQWYNGRVQ 220

Query: 370 PGMLCAGFMEGKIDACKGDSGGPLVY--DNHDIWYIVGIVSWGQSCALPKKPGVYTRVTK 427
           P  +CAG+  GKID C+GDSGGPL+        + +VGI SWG  CA  K+PG+YT    
Sbjct: 221 PTNVCAGYPVGKIDTCQGDSGGPLMCKDSKESAYVVVGITSWGVGCARAKRPGIYTATWP 280

Query: 428 YRDWIASKTG 437
           Y +WIASK G
Sbjct: 281 YLNWIASKIG 290


>gi|4503627 coagulation factor XI precursor [Homo sapiens]
          Length = 625

 Score =  184 bits (466), Expect = 2e-46
 Identities = 99/267 (37%), Positives = 155/267 (58%), Gaps = 14/267 (5%)

Query: 181 LLNSRCGIRMTSSNMPLPASSSTQRI---VQGRETAMEGEWPWQASLQLIG--SGHQCGA 235
           +L+ R GI   +  +    +  T +I   + G   ++ GEWPWQ +L        H CG 
Sbjct: 359 ILHGRGGISGYTLRLCKMDNECTTKIKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGG 418

Query: 236 SLISNTWLLTAAHCFWKNKDPTQWIATFGATITPPAVKRN-----VRKIILHENYHRETN 290
           S+I N W+LTAAHCF+  + P + +  +   +    +K +     V++II+H+ Y    +
Sbjct: 419 SIIGNQWILTAAHCFYGVESP-KILRVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAES 477

Query: 291 ENDIALVQLSTGVEFSNIVQRVCLPDSSIKLPPKTSVFVTGFGSIVDDGPIQNTLRQARV 350
             DIAL++L T V +++  + +CLP    +    T  +VTG+G       IQNTL++A++
Sbjct: 478 GYDIALLKLETTVNYTDSQRPICLPSKGDRNVIYTDCWVTGWGYRKLRDKIQNTLQKAKI 537

Query: 351 ETISTDVCNRKDVYDG-LITPGMLCAGFMEGKIDACKGDSGGPLVYDNHDIWYIVGIVSW 409
             ++ + C ++  Y G  IT  M+CAG+ EG  DACKGDSGGPL   ++++W++VGI SW
Sbjct: 538 PLVTNEECQKR--YRGHKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSW 595

Query: 410 GQSCALPKKPGVYTRVTKYRDWIASKT 436
           G+ CA  ++PGVYT V +Y DWI  KT
Sbjct: 596 GEGCAQRERPGVYTNVVEYVDWILEKT 622


>gi|117956391 protease, serine, 33 [Homo sapiens]
          Length = 280

 Score =  181 bits (460), Expect = 9e-46
 Identities = 102/246 (41%), Positives = 142/246 (57%), Gaps = 15/246 (6%)

Query: 203 TQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDPTQWIAT 262
           + RIV GR+   +GEWPWQAS+Q  G+ H CG SLI+  W+LTAAHCF +   P ++   
Sbjct: 34  SSRIVGGRD-GRDGEWPWQASIQHRGA-HVCGGSLIAPQWVLTAAHCFPRRALPAEYRVR 91

Query: 263 FGA----TITPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCLPDSS 318
            GA    + +P  +   VR+++L  +Y  +    D+AL+QL   V  S  VQ VCLP   
Sbjct: 92  LGALRLGSTSPRTLSVPVRRVLLPPDYSEDGARGDLALLQLRRPVPLSARVQPVCLPVPG 151

Query: 319 IKLPPKTSVFVTGFGSIVDDGPIQN--TLRQARVETISTDVCNR-----KDV--YDGLIT 369
            + PP T   VTG+GS+    P+     L+  RV  + +  C+       DV   + ++ 
Sbjct: 152 ARPPPGTPCRVTGWGSLRPGVPLPEWRPLQGVRVPLLDSRTCDGLYHVGADVPQAERIVL 211

Query: 370 PGMLCAGFMEGKIDACKGDSGGPLVYDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYR 429
           PG LCAG+ +G  DAC+GDSGGPL       W +VG+VSWG+ CALP +PGVYT V  Y 
Sbjct: 212 PGSLCAGYPQGHKDACQGDSGGPLTCLQSGSWVLVGVVSWGKGCALPNRPGVYTSVATYS 271

Query: 430 DWIASK 435
            WI ++
Sbjct: 272 PWIQAR 277


>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
          Length = 457

 Score =  181 bits (459), Expect = 1e-45
 Identities = 103/265 (38%), Positives = 151/265 (56%), Gaps = 21/265 (7%)

Query: 175 SKKMRNLLNSRCGIRMTSSNMPLPASSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCG 234
           S ++ +L  S CG R  +S           RIV G+  A  G WPWQAS+ L G  H CG
Sbjct: 198 SGQVVSLRCSECGARPLAS-----------RIVGGQSVA-PGRWPWQASVAL-GFRHTCG 244

Query: 235 ASLISNTWLLTAAHCF--WKNKDPTQWIATFGATITPPAVKRN----VRKIILHENYHRE 288
            S+++  W++TAAHC   ++    + W    G  ++  AV+ +    V +II H  Y  +
Sbjct: 245 GSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGL-VSHSAVRPHQGALVERIIPHPLYSAQ 303

Query: 289 TNENDIALVQLSTGVEFSNIVQRVCLPDSSIKLPPKTSVFVTGFGSIVDDGPIQNTLRQA 348
            ++ D+AL++L T + FS+ V  VCLP      P  +  +V+G+G         + + Q 
Sbjct: 304 NHDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQD 363

Query: 349 RVETI-STDVCNRKDVYDGLITPGMLCAGFMEGKIDACKGDSGGPLVYDNHDIWYIVGIV 407
            V  + ST +CN   VY G +TP MLCAG+++G+ DAC+GDSGGPLV  + D W +VG+V
Sbjct: 364 TVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVV 423

Query: 408 SWGQSCALPKKPGVYTRVTKYRDWI 432
           SWG+ CA P  PGVY +V ++ DWI
Sbjct: 424 SWGRGCAEPNHPGVYAKVAEFLDWI 448


>gi|222831592 transmembrane protease, serine 7 [Homo sapiens]
          Length = 717

 Score =  180 bits (457), Expect = 2e-45
 Identities = 107/242 (44%), Positives = 142/242 (58%), Gaps = 13/242 (5%)

Query: 199 ASSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNK--DP 256
           +SS+  RI+ G +T +EG WPWQ SL  +GS + CGAS+IS  WLL+AAHCF  N+  DP
Sbjct: 473 SSSALHRIIGGTDT-LEGGWPWQVSLHFVGSAY-CGASVISREWLLSAAHCFHGNRLSDP 530

Query: 257 TQWIATFGATITPPA-VKRNVRKIILHENYHRETNENDIALVQLSTG--VEFSNIVQRVC 313
           T W A  G  +   A     VR+I++HE Y+ +T + DIAL+QLS         ++Q +C
Sbjct: 531 TPWTAHLGMYVQGNAKFVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQPIC 590

Query: 314 LPDSSIKLPPKTSVFVTGFGSIVD-DGPIQNTLRQARVETISTDVCNRKDVYDGLITPGM 372
           +P +  ++      +VTG+G   + D      L+QA VE I   +C     Y G+IT  M
Sbjct: 591 IPPTGQRVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLC--VSTY-GIITSRM 647

Query: 373 LCAGFMEGKIDACKGDSGGPLV--YDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRD 430
           LCAG M GK DACKGDSGGPL     +   W + GIVSWG     P  PGVYTRV+ +  
Sbjct: 648 LCAGIMSGKRDACKGDSGGPLSCRRKSDGKWILTGIVSWGHGSGRPNFPGVYTRVSNFVP 707

Query: 431 WI 432
           WI
Sbjct: 708 WI 709



 Score = 37.7 bits (86), Expect = 0.021
 Identities = 21/98 (21%), Positives = 51/98 (52%)

Query: 65  FKVTNIKYKENYGIRSSREFIERSHQIERMMSRIFRHSSVGGRFIKSHVIKLSPDEQGVD 124
           F++TNI++   Y  + SREF+  S  ++++++ ++  S+    + +S V  +S ++ G+ 
Sbjct: 2   FRITNIEFLPEYRQKESREFLSVSRTVQQVINLVYTTSAFSKFYEQSVVADVSNNKGGLL 61

Query: 125 ILIVLIFRYPSTDSAEQIKKKIEKALYQSLKTKQLSLT 162
           +   ++F  P        +  +   L  S++T  ++ T
Sbjct: 62  VHFWIVFVMPRAKGHIFCEDCVAAILKDSIQTSIINRT 99


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score =  179 bits (455), Expect = 3e-45
 Identities = 99/237 (41%), Positives = 141/237 (59%), Gaps = 11/237 (4%)

Query: 203 TQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNK--DPTQWI 260
           + RIV G  ++ EGEWPWQASLQ+ G  H CG +LI++ W++TAAHCF ++       W 
Sbjct: 574 SSRIVGGAVSS-EGEWPWQASLQVRGR-HICGGALIADRWVITAAHCFQEDSMASTVLWT 631

Query: 261 ATFGATIT----PPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCLPD 316
              G        P  V   V +++LH  +  ++++ D+AL+QL   V  S  V+ VCLP 
Sbjct: 632 VFLGKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRPVCLPA 691

Query: 317 SSIKLPPKTSVFVTGFGSIVDDGPIQNTLRQARVETISTDVCNRKDVYDGLITPGMLCAG 376
            S    P    ++TG+G++ + GPI N L++  V+ I  D+C+  +VY   +TP MLCAG
Sbjct: 692 RSHFFEPGLHCWITGWGALREGGPISNALQKVDVQLIPQDLCS--EVYRYQVTPRMLCAG 749

Query: 377 FMEGKIDACKGDSGGPLVYDN-HDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDWI 432
           + +GK DAC+GDSGGPLV       W++ G+VSWG  C  P   GVYTR+T    WI
Sbjct: 750 YRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVISWI 806


>gi|21614531 testisin isoform 2 [Homo sapiens]
          Length = 312

 Score =  177 bits (449), Expect = 2e-44
 Identities = 106/277 (38%), Positives = 151/277 (54%), Gaps = 33/277 (11%)

Query: 181 LLNSRCGIRMTSSNMPLPASSS------TQRIVQGRETAMEGEWPWQASLQLIGSGHQCG 234
           LL +R G+R   S    P S        T RIV G +  + G WPWQ SL+L  S H CG
Sbjct: 11  LLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAEL-GRWPWQGSLRLWDS-HVCG 68

Query: 235 ASLISNTWLLTAAHCFWKN-KDPTQWIATFGATITPPA--------VKRNVRKIILHENY 285
            SL+S+ W LTAAHCF  +  DP+ W+  FG   + P+         +  V  I L   Y
Sbjct: 69  VSLLSHRWALTAAHCFETDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSPRY 128

Query: 286 HRETNENDIALVQLSTGVEFSNIVQRVCLPDSSIKLPPKTSVFVTGFGSIVDDG--PIQN 343
               +  DIALV+LS  V ++  +Q +CL  S+ +   +T  +VTG+G I +D   P  +
Sbjct: 129 -LGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPSPH 187

Query: 344 TLRQARVETISTDVCN--------RKDVYDGLITPGMLCAGFMEGKIDACKGDSGGPLVY 395
           TL++ +V  I+  +CN        RKD++       M+CAG  +G  DAC GDSGGPL  
Sbjct: 188 TLQEVQVAIINNSMCNHLFLKYSFRKDIFGD-----MVCAGNAQGGKDACFGDSGGPLAC 242

Query: 396 DNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDWI 432
           + + +WY +G+VSWG  C  P +PGVYT ++ + +WI
Sbjct: 243 NKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWI 279


>gi|13994276 marapsin [Homo sapiens]
          Length = 290

 Score =  175 bits (444), Expect = 6e-44
 Identities = 103/241 (42%), Positives = 135/241 (56%), Gaps = 15/241 (6%)

Query: 205 RIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDPTQWIATFG 264
           R+V G++T  EGEWPWQ S+Q  GS H CG SLI+  W+LTAAHCF    + + +    G
Sbjct: 34  RMVGGQDT-QEGEWPWQVSIQRNGS-HFCGGSLIAEQWVLTAAHCFRNTSETSLYQVLLG 91

Query: 265 ATIT----PPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCLPDSSIK 320
           A       P A+   VR++  +  Y    +  D+ALV+L   V F+N +  VCLPD S+ 
Sbjct: 92  ARQLVQPGPHAMYARVRQVESNPLYQGTASSADVALVELEAPVPFTNYILPVCLPDPSVI 151

Query: 321 LPPKTSVFVTGFGSIVDDG--PIQNTLRQARVETISTDVCN---RKDVYDGL----ITPG 371
                + +VTG+GS  ++   P    L++  V  I T  CN    KD   G     I   
Sbjct: 152 FETGMNCWVTGWGSPSEEDLLPEPRILQKLAVPIIDTPKCNLLYSKDTEFGYQPKTIKND 211

Query: 372 MLCAGFMEGKIDACKGDSGGPLVYDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDW 431
           MLCAGF EGK DACKGDSGGPLV      W   G++SWG+ CA   +PGVY RVT + +W
Sbjct: 212 MLCAGFEEGKKDACKGDSGGPLVCLVGQSWLQAGVISWGEGCARQNRPGVYIRVTAHHNW 271

Query: 432 I 432
           I
Sbjct: 272 I 272


>gi|5803197 testisin isoform 1 [Homo sapiens]
          Length = 314

 Score =  175 bits (444), Expect = 6e-44
 Identities = 106/279 (37%), Positives = 150/279 (53%), Gaps = 35/279 (12%)

Query: 181 LLNSRCGIRMTSSNMPLPASSS------TQRIVQGRETAMEGEWPWQASLQLIGSGHQCG 234
           LL +R G+R   S    P S        T RIV G +  + G WPWQ SL+L  S H CG
Sbjct: 11  LLLARAGLRKPESQEAAPLSGPCGRRVITSRIVGGEDAEL-GRWPWQGSLRLWDS-HVCG 68

Query: 235 ASLISNTWLLTAAHCFWKNKD---PTQWIATFGATITPPA--------VKRNVRKIILHE 283
            SL+S+ W LTAAHCF    D   P+ W+  FG   + P+         +  V  I L  
Sbjct: 69  VSLLSHRWALTAAHCFETYSDLSDPSGWMVQFGQLTSMPSFWSLQAYYTRYFVSNIYLSP 128

Query: 284 NYHRETNENDIALVQLSTGVEFSNIVQRVCLPDSSIKLPPKTSVFVTGFGSIVDDG--PI 341
            Y    +  DIALV+LS  V ++  +Q +CL  S+ +   +T  +VTG+G I +D   P 
Sbjct: 129 RY-LGNSPYDIALVKLSAPVTYTKHIQPICLQASTFEFENRTDCWVTGWGYIKEDEALPS 187

Query: 342 QNTLRQARVETISTDVCN--------RKDVYDGLITPGMLCAGFMEGKIDACKGDSGGPL 393
            +TL++ +V  I+  +CN        RKD++       M+CAG  +G  DAC GDSGGPL
Sbjct: 188 PHTLQEVQVAIINNSMCNHLFLKYSFRKDIFGD-----MVCAGNAQGGKDACFGDSGGPL 242

Query: 394 VYDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRDWI 432
             + + +WY +G+VSWG  C  P +PGVYT ++ + +WI
Sbjct: 243 ACNKNGLWYQIGVVSWGVGCGRPNRPGVYTNISHHFEWI 281


>gi|110815798 ovochymase 1 [Homo sapiens]
          Length = 1134

 Score =  173 bits (439), Expect = 2e-43
 Identities = 105/286 (36%), Positives = 159/286 (55%), Gaps = 18/286 (6%)

Query: 160 SLTINKPSFRLTPIDS--KKMRNLLNSRCGIRMTSSNMPLPASSSTQRIVQGRETAMEGE 217
           S ++NK   +L P ++    ++ +L+  CGI       P  +     R + G E A    
Sbjct: 533 SESLNKFEPKLPPQNNPVSTVKAILHDVCGI-------PPFSPQWLSRRIAGGEEACPHC 585

Query: 218 WPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDPTQWIATFGA----TITPPAVK 273
           WPWQ  L+ +G  +QCG ++I+  W+LTAAHC     +P  W    G             
Sbjct: 586 WPWQVGLRFLGD-YQCGGAIINPVWILTAAHCVQLKNNPLSWTIIAGDHDRNLKESTEQV 644

Query: 274 RNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQRVCLPDSSIKLPPKTSVFVTGFG 333
           R  + II+HE+++  + ++DIAL+QLS+ +E++++V+ VCLP S+  L       VTG+G
Sbjct: 645 RRAKHIIVHEDFNTLSYDSDIALIQLSSPLEYNSVVRPVCLPHSAEPLFSSEICAVTGWG 704

Query: 334 SIVDDGPIQNTLRQARVETISTDVCNRK--DVYDGLITPGMLCAGF-MEGKIDACKGDSG 390
           SI  DG + + L+Q +V  +  +VC       + G IT  M+CAGF   G+ D C+GDSG
Sbjct: 705 SISADGGLASRLQQIQVHVLEREVCEHTYYSAHPGGITEKMICAGFAASGEKDFCQGDSG 764

Query: 391 GPLVYDNHDIWYIV-GIVSWGQSCALPKKPGVYTRVTKYRDWIASK 435
           GPLV  + +  +++ GIVSWG  C  P KPGV+ RV  + DWI SK
Sbjct: 765 GPLVCRHENGPFVLYGIVSWGAGCVQPWKPGVFARVMIFLDWIQSK 810



 Score =  126 bits (317), Expect = 3e-29
 Identities = 96/273 (35%), Positives = 128/273 (46%), Gaps = 24/273 (8%)

Query: 182 LNSRCGIRMTSSNMPLPASSST--QRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLIS 239
           L  +CGIRM +     PA  S    RI   R + + G  PWQ SL+     H CG SLI 
Sbjct: 21  LGLKCGIRMVNMKSKEPAVGSRFFSRISSWRNSTVTGH-PWQVSLKS-DEHHFCGGSLIQ 78

Query: 240 NTWLLTAAHCF--WKNKDPTQWIATFGATITPPAVKRN----VRKIILHENYH-RETNEN 292
              ++TAAHC      K       T G        K+     V KII H  Y+ RE    
Sbjct: 79  EDRVVTAAHCLDSLSEKQLKNITVTSGEYSLFQKDKQEQNIPVSKIITHPEYNSREYMSP 138

Query: 293 DIALVQLSTGVEFSNIVQRVCLPDSSIKLPPKTSVFVTGFGSIVDDGPIQNTLRQARVET 352
           DIAL+ L   V+F N VQ +CLPDS  K+ P      +G+G I       N L++  +  
Sbjct: 139 DIALLYLKHKVKFGNAVQPICLPDSDDKVEPGILCLSSGWGKISKTSEYSNVLQEMELPI 198

Query: 353 ISTDVCNR--KDVYDGLITPGMLCAGFMEGKIDACKGDSGGPLV-YDNHDIWYIVGIVSW 409
           +    CN   K +    +   MLCAGF +  +DAC+GDSGGPLV      IW + GI SW
Sbjct: 199 MDDRACNTVLKSMNLPPLGRTMLCAGFPDWGMDACQGDSGGPLVCRRGGGIWILAGITSW 258

Query: 410 GQSCALPKKP----------GVYTRVTKYRDWI 432
              CA    P          G++++V++  D+I
Sbjct: 259 VAGCAGGSVPVRNNHVKASLGIFSKVSELMDFI 291


>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
          Length = 567

 Score =  173 bits (438), Expect = 3e-43
 Identities = 106/305 (34%), Positives = 157/305 (51%), Gaps = 22/305 (7%)

Query: 137 DSAEQIKKKIEKALYQSLKTKQLSLTINKPSFRLTPIDSKKMRNLLNSRCGIRMTSSNMP 196
           +SA +  +   +    S    + + TI + S   +   S++  +L  S CG+R       
Sbjct: 269 ESAHRTTEVAHRDFANSFSILRYNSTIQE-SLHRSECPSQRYISLQCSHCGLR------- 320

Query: 197 LPASSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTAAHCFWKNKDP 256
               + T RIV G   A + +WPWQ SL   G+ H CG +LI   W+LTAAHCF+  ++ 
Sbjct: 321 ----AMTGRIVGGA-LASDSKWPWQVSLHF-GTTHICGGTLIDAQWVLTAAHCFFVTREK 374

Query: 257 TQ-----WIATFGATITPPAVKRNVRKIILHENYHRETNENDIALVQLSTGVEFSNIVQR 311
                  +  T      P A   ++ +II++ NY  E ++ DIAL++LS  +  S  +  
Sbjct: 375 VLEGWKVYAGTSNLHQLPEAA--SIAEIIINSNYTDEEDDYDIALMRLSKPLTLSAHIHP 432

Query: 312 VCLPDSSIKLPPKTSVFVTGFGSIVD-DGPIQNTLRQARVETISTDVCNRKDVYDGLITP 370
            CLP          + ++TGFG   + D      LR+ +V  I    CN   VYD  +TP
Sbjct: 433 ACLPMHGQTFSLNETCWITGFGKTRETDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTP 492

Query: 371 GMLCAGFMEGKIDACKGDSGGPLVYDNHDIWYIVGIVSWGQSCALPKKPGVYTRVTKYRD 430
            M+CAG + G  D+C+GDSGGPLV + ++ WY+ G+ SWG  C    KPGVYT+VT+   
Sbjct: 493 RMMCAGDLRGGRDSCQGDSGGPLVCEQNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLP 552

Query: 431 WIASK 435
           WI SK
Sbjct: 553 WIYSK 557


>gi|11545839 protease, serine, 22 [Homo sapiens]
          Length = 317

 Score =  173 bits (438), Expect = 3e-43
 Identities = 100/257 (38%), Positives = 152/257 (59%), Gaps = 15/257 (5%)

Query: 190 MTSSNMPLP-ASSSTQRI--VQGRETAMEGEWPWQASLQLIGSGHQCGASLISNTWLLTA 246
           + ++ +P+P A    Q++  V G E + + EWPW  S+Q  G+ H C  SL+++ W++TA
Sbjct: 30  LNAARIPVPPACGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGT-HHCAGSLLTSRWVITA 88

Query: 247 AHCFWKNKD-PTQWIATFGA-TITPP---AVKRNVRKIILHENYH-RETNENDIALVQLS 300
           AHCF  N + P  +    GA  +  P   + K  V  +  H  Y  +E    DIALV+L 
Sbjct: 89  AHCFKDNLNKPYLFSVLLGAWQLGNPGSRSQKVGVAWVEPHPVYSWKEGACADIALVRLE 148

Query: 301 TGVEFSNIVQRVCLPDSSIKLPPKTSVFVTGFGSIVDDGPIQN--TLRQARVETISTDVC 358
             ++FS  V  +CLPD+SI LPP T  +++G+GSI D  P+ +  TL++ +V  I ++VC
Sbjct: 149 RSIQFSERVLPICLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVC 208

Query: 359 NR---KDVYDGLITPGMLCAGFMEGKIDACKGDSGGPLVYDNHDIWYIVGIVSWGQSCAL 415
           +    +    G IT  MLCAG++EG+ DAC GDSGGPL+      W + GI+SWG+ CA 
Sbjct: 209 SHLYWRGAGQGPITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAE 268

Query: 416 PKKPGVYTRVTKYRDWI 432
             +PGVY  ++ +R W+
Sbjct: 269 RNRPGVYISLSAHRSWV 285


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.135    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,685,801
Number of Sequences: 37866
Number of extensions: 643612
Number of successful extensions: 1979
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 164
Number of HSP's successfully gapped in prelim test: 13
Number of HSP's that attempted gapping in prelim test: 1312
Number of HSP's gapped (non-prelim): 226
length of query: 438
length of database: 18,247,518
effective HSP length: 105
effective length of query: 333
effective length of database: 14,271,588
effective search space: 4752438804
effective search space used: 4752438804
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.