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Search of human proteins with 194018482
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194018482 NLR family, pyrin domain containing 4 [Homo
sapiens]
(994 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 2023 0.0
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens] 792 0.0
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 741 0.0
gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens] 586 e-167
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho... 540 e-153
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom... 540 e-153
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 539 e-153
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 525 e-149
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 501 e-141
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 487 e-137
gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens] 477 e-134
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 474 e-133
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 466 e-131
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 462 e-130
gi|188536002 NLR family, pyrin domain containing 3 isoform d [Ho... 451 e-126
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof... 446 e-125
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 433 e-121
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 320 5e-87
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 320 5e-87
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 320 5e-87
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 318 2e-86
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 318 2e-86
gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens] 301 2e-81
gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens] 226 8e-59
gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Ho... 188 2e-47
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 184 3e-46
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens] 184 3e-46
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens] 184 3e-46
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens] 184 3e-46
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens] 184 3e-46
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 2023 bits (5241), Expect = 0.0
Identities = 994/994 (100%), Positives = 994/994 (100%)
Query: 1 MAASFFSDFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLI 60
MAASFFSDFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLI
Sbjct: 1 MAASFFSDFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLI 60
Query: 61 KHYEEQQAWNITLRIFQKMDRKDLCMKVMRERTGYTKTYQAHAKQKFSRLWSSKSVTEIH 120
KHYEEQQAWNITLRIFQKMDRKDLCMKVMRERTGYTKTYQAHAKQKFSRLWSSKSVTEIH
Sbjct: 61 KHYEEQQAWNITLRIFQKMDRKDLCMKVMRERTGYTKTYQAHAKQKFSRLWSSKSVTEIH 120
Query: 121 LYFEEEVKQEECDHLDRLFAPKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRD 180
LYFEEEVKQEECDHLDRLFAPKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRD
Sbjct: 121 LYFEEEVKQEECDHLDRLFAPKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRD 180
Query: 181 RFLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGL 240
RFLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGL
Sbjct: 181 RFLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGL 240
Query: 241 NEPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPR 300
NEPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPR
Sbjct: 241 NEPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPR 300
Query: 301 GFNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKD 360
GFNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKD
Sbjct: 301 GFNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKD 360
Query: 361 LALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLR 420
LALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLR
Sbjct: 361 LALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLR 420
Query: 421 RNGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDHPHPAVRCV 480
RNGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDHPHPAVRCV
Sbjct: 421 RNGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDHPHPAVRCV 480
Query: 481 QELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKLDAFFGFQLSQEIKQQIHQCLKSLGE 540
QELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKLDAFFGFQLSQEIKQQIHQCLKSLGE
Sbjct: 481 QELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKLDAFFGFQLSQEIKQQIHQCLKSLGE 540
Query: 541 RGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLKYCSSLR 600
RGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLKYCSSLR
Sbjct: 541 RGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLKYCSSLR 600
Query: 601 KLCFSVQNVFKKEDEHSSTSDYSLICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCN 660
KLCFSVQNVFKKEDEHSSTSDYSLICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCN
Sbjct: 601 KLCFSVQNVFKKEDEHSSTSDYSLICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCN 660
Query: 661 QLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNY 720
QLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNY
Sbjct: 661 QLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNY 720
Query: 721 PAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQLDTGVPLLCEALCSPDTV 780
PAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQLDTGVPLLCEALCSPDTV
Sbjct: 721 PAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQLDTGVPLLCEALCSPDTV 780
Query: 781 LVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDS 840
LVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDS
Sbjct: 781 LVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDS 840
Query: 841 LCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGL 900
LCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGL
Sbjct: 841 LCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGL 900
Query: 901 EECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKT 960
EECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKT
Sbjct: 901 EECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKT 960
Query: 961 DFDEETQALLTAEEERNPNLTITDDCDTITRVEI 994
DFDEETQALLTAEEERNPNLTITDDCDTITRVEI
Sbjct: 961 DFDEETQALLTAEEERNPNLTITDDCDTITRVEI 994
>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
Length = 991
Score = 792 bits (2046), Expect = 0.0
Identities = 413/986 (41%), Positives = 626/986 (63%), Gaps = 14/986 (1%)
Query: 1 MAASFFSDFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLI 60
MA SFFSDFGL+WYL+EL+KEEF KFKE LKQ + ELK IPW E+KKAS+E++A LL
Sbjct: 1 MAESFFSDFGLLWYLKELRKEEFWKFKELLKQPLEKFELKPIPWAELKKASKEDVAKLLD 60
Query: 61 KHYEEQQAWNITLRIFQKMDRKDLCMKVMRERTGYTKTYQAHAKQKFSRLWSSKSVTEIH 120
KHY +QAW +TL +F +++RKDL K E Y+ H K+ F +W ++ +
Sbjct: 61 KHYPGKQAWEVTLNLFLQINRKDLWTKAQEEMRNKLNPYRKHMKETFQLIWEKETCLHVP 120
Query: 121 LYFEEEVKQEECDHLDRLFAPKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRD 180
+F +E + E L+ + A + TV+++GP GIGKTTLL K+M+ W++ +++D
Sbjct: 121 EHFYKETMKNEYKELNDAYT---AAARRHTVVLEGPDGIGKTTLLRKVMLDWAEGNLWKD 177
Query: 181 RFLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGL 240
RF + F+ E+ + TSL +L+SR+WP+ + I +I SQPER+LF++D FE+L+ L
Sbjct: 178 RFTFVFFLNVCEMNGIAETSLLELLSRDWPESSEKIEDIFSQPERILFIMDGFEQLKFNL 237
Query: 241 NEPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPR 300
+ +DL D +++P+ ++LSSLL+KKMLPE+SLLIA+ + ++ + ++ +
Sbjct: 238 -QLKADLSDDWRQRQPMPIILSSLLQKKMLPESSLLIALGKLAMQKHYFMLRHPKLIKLL 296
Query: 301 GFNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKD 360
GF+ES++ YF FF + +A++ FN VR++ LF +C P CW++CT +KQ +++G+D
Sbjct: 297 GFSESEKKSYFSYFFGEKSKALKVFNFVRDNGPLFILCHNPFTCWLVCTCVKQRLERGED 356
Query: 361 LALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLR 420
L + Q+TT +Y+SF+ +F P + +LK+LC+LAAEG+WT TF F DLR
Sbjct: 357 LEINSQNTTYLYASFLTTVFKAGSQSFPPKVNRARLKSLCALAAEGIWTYTFVFSHGDLR 416
Query: 421 RNGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDHPHPAVRCV 480
RNG+ +++ +G ++L + G+ + F+H+CIQEFCAA+FYLLK D P+PA+ +
Sbjct: 417 RNGLSESEGVMWVGMRLLQRRGD---CFAFMHLCIQEFCAAMFYLLKRPKDDPNPAIGSI 473
Query: 481 QELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKLDAFFGFQLSQEIKQQIHQCLKSLGE 540
+L+ A+ + + +G F+ G+ ++ L+ FGF LS+++KQ+I QCL+SL +
Sbjct: 474 TQLVRASVVQPQTL-LTQVGIFMFGISTEEIVSMLETSFGFPLSKDLKQEITQCLESLSQ 532
Query: 541 RGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLKYCSSLR 600
+ + +F LFE Q+ FV + +N +E +I + LV++++CLK+C L
Sbjct: 533 CEADREAIAFQELFIGLFETQEKEFVTKVMNFFEEVFIYIGNIEHLVIASFCLKHCQHLT 592
Query: 601 KLCFSVQNVFKKEDEHSSTSDYS--LICWHHICSVLTTSGHLRELQVQDSTLSESTFVTW 658
L V+N+F D+ SDY+ L+ W +CS+ T+ + + L +++++L + +
Sbjct: 593 TLRMCVENIFP--DDSGCISDYNEKLVYWRELCSMFITNKNFQILDMENTSLDDPSLAIL 650
Query: 659 CNQLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDAL 718
C L P C+L+KL +V F G LF+ + + P LK LS T LS+ DIR LC+ L
Sbjct: 651 CKALAQPVCKLRKLIFTSVYF-GHDSELFKAVLHNPHLKLLSLYGTSLSQSDIRHLCETL 709
Query: 719 NYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQL-DTGVPLLCEALCSP 777
+P ++EL L C +S CE +A +L N KL +L++ N L D G+ LLCEAL
Sbjct: 710 KHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHS 769
Query: 778 DTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCC 837
L LML +C L+ C+ ISE+LL +KS+ LDL +N L+D G+ +LC ALKHP C
Sbjct: 770 HCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCS 829
Query: 838 LDSLCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEI 897
+ L L+ CF+T+ C+D+A+ LI N LK L++G NEIGD GV+ LC AL H C+LE
Sbjct: 830 IRELWLMGCFLTSDSCKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLEC 889
Query: 898 LGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGL 957
LGL+ C +T CC D+A+ L KTL+ LNL LD VVVLCEAL HP+CALQ+LGL
Sbjct: 890 LGLQTCPITRACCDDIAAALIACKTLRSLNLDWIALDADAVVVLCEALSHPDCALQMLGL 949
Query: 958 RKTDFDEETQALLTAEEERNPNLTIT 983
K+ FDEETQ +L + EE+ P+LTI+
Sbjct: 950 HKSGFDEETQKILMSVEEKIPHLTIS 975
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 741 bits (1914), Expect = 0.0
Identities = 412/1076 (38%), Positives = 617/1076 (57%), Gaps = 91/1076 (8%)
Query: 2 AASFFSDFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIK 61
++SFF DFGL+ YLEEL KEE FK LK+ T++ E PW EVKKA RE+LANL+ K
Sbjct: 6 SSSFFPDFGLLLYLEELNKEELNTFKLFLKE-TMEPEHGLTPWNEVKKARREDLANLMKK 64
Query: 62 HYEEQQAWNITLRIFQKMDRKDLCMKVMRE-------------RTGYTKT---------- 98
+Y ++AW+++L+IF KM+ KDLC + E + G T+
Sbjct: 65 YYPGEKAWSVSLKIFGKMNLKDLCERAKEEINWSAQTIGPDDAKAGETQEDQEAVLGDGT 124
Query: 99 -YQAHAKQKFSRLWSSKSVTEIHLYFEEEVKQEECDHLDRLF-APKEAGKQPRTVIIQGP 156
Y+ K+KF W KS+ F + +++ L+ LF + G QP+ V++QG
Sbjct: 125 EYRNRIKEKFCITWDKKSLAGKPEDFHHGIAEKDRKLLEHLFDVDVKTGAQPQIVVLQGA 184
Query: 157 QGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELPPTSLADLISREWPDPAAPI 216
G+GKTTL+ K M+ W++ +++ RF Y FY RE+ +L S A LIS++WP PI
Sbjct: 185 AGVGKTTLVRKAMLDWAEGSLYQQRFKYVFYLNGREINQLKERSFAQLISKDWPSTEGPI 244
Query: 217 TEIVSQPERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLL 276
EI+ QP LLF+IDSF+EL EP+ LC D ++ PV L+SSLLRK MLPEASLL
Sbjct: 245 EEIMYQPSSLLFIIDSFDELNFAFEEPEFALCEDWTQEHPVSFLMSSLLRKVMLPEASLL 304
Query: 277 IAIKPVCPKELRDQVTISEIYQPRGFNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFS 336
+ + K L+ + + G +E R Y FF+D + AM+ F+ ++ +E LFS
Sbjct: 305 VTTRLTTSKRLKQLLKNHHYVELLGMSEDAREEYIYQFFEDKRWAMKVFSSLKSNEMLFS 364
Query: 337 ICQIPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQL 396
+CQ+PL+CW CT LKQ+M+KG D+ LTCQ+TT++++ ++ +LFTP P+ Q QL
Sbjct: 365 MCQVPLVCWAACTCLKQQMEKGGDVTLTCQTTTALFTCYISSLFTPVDGGSPSLPNQAQL 424
Query: 397 KALCSLAAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKILLKYGERESSYVFLHVCIQ 456
+ LC +AA+G+WT T+ F ++LRR G+ +D+ + + + I+ K E E+ YVF H+ +Q
Sbjct: 425 RRLCQVAAKGIWTMTYVFYRENLRRLGLTQSDVSSFMDSNIIQKDAEYENCYVFTHLHVQ 484
Query: 457 EFCAALFYLLKSHLDHPHPAVRCVQELL-VANFEKARRAHWIFLGCFLTGLLNKKEQEKL 515
EF AA+FY+LK + +P+ + ++L + + H + CFL GLLN+ ++L
Sbjct: 485 EFFAAMFYMLKGSWEAGNPSCQPFEDLKSLLQSTSYKDPHLTQMKCFLFGLLNEDRVKQL 544
Query: 516 DAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQE 575
+ F ++S +IK ++ QC++ LG Q+ L +F+CL+E QD AF+ QA+ +
Sbjct: 545 ERTFNCKMSLKIKSKLLQCMEVLGNSDYSPSQLGFLELFHCLYETQDKAFISQAMRCFPK 604
Query: 576 ANFHIIDNVDLVVSAYCLKYCSSLRKLCFSVQNVFKKEDEHSST------SDYSLICWHH 629
+I + + L+VS++CLK+C LR + SV VF+K+ +S D CW
Sbjct: 605 VAINICEKIHLLVSSFCLKHCRCLRTIRLSVTVVFEKKILKTSLPTNTWDGDRITHCWQD 664
Query: 630 ICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSVLLFEV 689
+CSVL T+ HLREL + S L +S ++LRHP+C+LQKL + ++F +
Sbjct: 665 LCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITFPDGCQDISTS 724
Query: 690 LFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTN 749
L + +L +L + + + ++SLC+AL +P ++ L L +C+L+ C ++ L
Sbjct: 725 LIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIR 784
Query: 750 NKKLTYLNVSCNQL-DTGVPLLCEAL---------------------------------- 774
++ L +LN+S N L D GV LLCEAL
Sbjct: 785 SQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKR 844
Query: 775 ----CSPDTVL-------------------VYLMLAFCHLSEQCCEYISEMLLRNKSVRY 811
C D VL L+L CH + EY+S LL NKS+ +
Sbjct: 845 LTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTH 904
Query: 812 LDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQI 871
LDL +N L+D G+K LC+ +HP C L L L+ C +T A C DLAS +++N NL+ L +
Sbjct: 905 LDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDL 964
Query: 872 GCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLN 931
G N++ D GV++LC AL + +C ++ LGLE CGLTS CC+DL+S L C+K L ++NLT N
Sbjct: 965 GNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQN 1024
Query: 932 TLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCD 987
TL + G+V L + L+ P+C LQVLGL K FDEE Q LL A NP+L I DC+
Sbjct: 1025 TLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHLIIKPDCN 1080
>gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]
Length = 1033
Score = 586 bits (1511), Expect = e-167
Identities = 346/989 (34%), Positives = 538/989 (54%), Gaps = 22/989 (2%)
Query: 1 MAASFFSDFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLI 60
MA S +DF L+WYLE L +EF+ FK++L + L +L Q P ++ K EELAN+L
Sbjct: 1 MAESDSTDFDLLWYLENLSDKEFQSFKKYLARKILDFKLPQFPLIQMTK---EELANVLP 57
Query: 61 KHYEEQQAWNITLRIFQKMDRKDLCMKVMRERTGYTKTYQAHAKQKFSRLWSSKSVTEIH 120
YE Q WN+ IF M ++DLC K++ R + +A ++KF W S + + H
Sbjct: 58 ISYEGQYIWNMLFSIFSMMRKEDLCRKIIGRRNRNQEACKAVMRRKFMLQWESHTFGKFH 117
Query: 121 LYFEEEVKQEECDHLDRLF-APKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFR 179
F +V + L + + V + G + GKT ++ ++ W ++++
Sbjct: 118 YKFFRDVSSDVFYILQLAYDSTSYYSANNLNVFLMGERASGKTIVINLAVLRWIKGEMWQ 177
Query: 180 DRFLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGG 239
+ Y + E+ ++ +SLA+LI+++WPD API +I+S P++LLF+++ + ++
Sbjct: 178 NMISYVVHLTAHEINQMTNSSLAELIAKDWPDGQAPIADILSDPKKLLFILEDLDNIRFE 237
Query: 240 LNEPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQP 299
LN +S LC + +K P+ VLL SLL++KM P LI+ +P ++ + +
Sbjct: 238 LNVNESALCSNSTQKVPIPVLLVSLLKRKMAPGCWFLISSRPTRGNNVKTFLKEVDCCTT 297
Query: 300 RGFNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGK 359
+ R +YF FFKD +RA A LV E E L +C++ +LCWI CT LK++M KG+
Sbjct: 298 LQLSNGKREIYFNSFFKDRQRASAALQLVHEDEILVGLCRVAILCWITCTVLKRQMDKGR 357
Query: 360 DLALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQ--LKALCSLAAEGMWTDTFEFCED 417
D L CQ+ T +++ F+ + T E G T H LK LC LAA G++ T F +
Sbjct: 358 DFQLCCQTPTDLHAHFLADALTSEA--GLTANQYHLGLLKRLCLLAAGGLFLSTLNFSGE 415
Query: 418 DLRRNGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDHPHPAV 477
DLR G +AD+ L ILL + Y F+H+ +QEFC A+ +L+ P+ +
Sbjct: 416 DLRCVGFTEADVSVLQAANILLPSNTHKDRYKFIHLNVQEFCTAIAFLMAV----PNYLI 471
Query: 478 RCVQELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKLDAFFGFQLSQ--EIKQQIHQCL 535
E+ + +F F+ GLLN ++ L+ FG+QL K +
Sbjct: 472 PSGSREYKEKREQYSDFNQVFT--FIFGLLNANRRKILETSFGYQLPMVDSFKWYSVGYM 529
Query: 536 KSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLKY 595
K L +P+ + +FYCL+E ++ FVK V+ L E ++ + D++VS YCL Y
Sbjct: 530 KHLDR--DPEKLTHHMPLFYCLYENREEEFVKTIVDALMEVTVYLQSDKDMMVSLYCLDY 587
Query: 596 CSSLRKLCFSVQNVFKKED---EHSSTSDYSLICWHHICSVLTTSGHLRELQVQDSTLSE 652
C LR L SVQ +F+ ++ +++ SL+ W ICS+ T LREL + D+ L+
Sbjct: 588 CCHLRTLKLSVQRIFQNKEPLIRPTASQMKSLVYWREICSLFYTMESLRELHIFDNDLNG 647
Query: 653 STFVTWCNQLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIR 712
+ L H SC+L+ L ++ VS + L + L L YLS T +S +
Sbjct: 648 ISERILSKALEHSSCKLRTLKLSYVSTASGFEDLLKALARNRSLTYLSINCTSISLNMFS 707
Query: 713 SLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQLDT-GVPLLC 771
L D L+ P + L+L+ C L +CE +A LL + L L +S N L + G+ +LC
Sbjct: 708 LLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMNILC 767
Query: 772 EALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEAL 831
+AL P+ L+ L+L FC L+E CC + +LL + ++R LDL N LK+ G+ + L
Sbjct: 768 DALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPL 827
Query: 832 KHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHT 891
P C L+ L L CF ++ C+ +A + +N+ L+ L+IG N+I D G+QLLC L H
Sbjct: 828 LFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHP 887
Query: 892 DCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECA 951
+C L +GLEEC LTS CC+ LASVLT +KTL++LNL N L + GV L E+L P+C
Sbjct: 888 NCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCV 947
Query: 952 LQVLGLRKTDFDEETQALLTAEEERNPNL 980
L+V+GL T + +TQ LL +ER P+L
Sbjct: 948 LKVVGLPLTGLNTQTQQLLMTVKERKPSL 976
>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 540 bits (1391), Expect = e-153
Identities = 347/1049 (33%), Positives = 537/1049 (51%), Gaps = 111/1049 (10%)
Query: 14 YLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWNITL 73
YLE+L+ + +KFK HL+ Q +P + +KA +LA L+I E++AW + +
Sbjct: 13 YLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAV 72
Query: 74 RIFQKMDRKDLCMKVMRE------------------------------------------ 91
IF ++R+DL K R+
Sbjct: 73 WIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKM 132
Query: 92 RTGYTKTYQAHAKQKF-------SRLWSSKSV----TEIHLYFEEEVKQEE--------- 131
+ Y K Y+ + + +F +RL S S+ T + L E +QE
Sbjct: 133 KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
Query: 132 ---CDH------LDRLFAPKEAGKQP-RTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDR 181
C+ ++ LF P + +P TV+ QG GIGKT L K+M+ W+ +++DR
Sbjct: 193 TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
Query: 182 FLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGLN 241
F Y FY CRE+ + SL DLI PDP PI +IV +P R+LF++D F+ELQG +
Sbjct: 253 FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
Query: 242 EPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRG 301
E LC D + +LLSSL+RKK+LPEASLLI +PV ++L+ + + G
Sbjct: 313 EHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILG 372
Query: 302 FNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDL 361
F+E+ R YF +F D +A AF+L++E+E LF++C IPL+CWI+CT LKQ+M+ GK L
Sbjct: 373 FSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSL 432
Query: 362 ALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLRR 421
A T ++TT+VY F+ +L P G H L LCSLAA+G+W F E DLR
Sbjct: 433 AQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAH-LWGLCSLAADGIWNQKILFEESDLRN 491
Query: 422 NGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDH----PHPAV 477
+G+ AD+ A L + K + E Y F+H+ QEF AA++YLL+ + P +
Sbjct: 492 HGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRL 551
Query: 478 RCVQE---LLVANFEKARRAHWIFLGCFLTGLLNKKEQEKLDAFFGFQLSQEIKQQIHQC 534
+ +L+ N+ K + + IF+ FL GL+N++ L+ ++SQ+I+ ++ +
Sbjct: 552 KLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKW 611
Query: 535 LKSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLK 594
++ + Q Q L +FYCL+EMQ+ FV++A++ + ++ +D +VS++C++
Sbjct: 612 IEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIE 671
Query: 595 YCSSLRKLCFSVQNVFKKEDEHSSTSDYSLICWHHICSVLTTSGHLRELQVQDSTLSEST 654
C + L + KE+E R L + L S+
Sbjct: 672 NCHRVESLSLGFLHNMPKEEEEEEKEG-------------------RHLDMVQCVLPSSS 712
Query: 655 FVTWCNQLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIRSL 714
+ L +N+ S LF VL L L + L +R L
Sbjct: 713 HAACSHGL-----------VNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVL 761
Query: 715 CDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQL-DTGVPLLCEA 773
C+ L +P N++ L L C LS C ++ +L++N+KL L++S N L D G+ LLC
Sbjct: 762 CETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVG 821
Query: 774 LCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKH 833
L L L L C L+ CC+ ++ +L + S+ L + N L D G+ LCE K+
Sbjct: 822 LKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKN 881
Query: 834 PDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDC 893
P C L L LV +T+ C L+S L +NQNL L + N +GD G++LLC L H DC
Sbjct: 882 PQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDC 941
Query: 894 RLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQ 953
+L++L L+ C LTS CC DL+++LT S++L++L+L N L GV++ CE L+ C LQ
Sbjct: 942 KLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQ 1001
Query: 954 VLGLRKTDFDEETQALLTAEEERNPNLTI 982
LGL + F+ ET++ L +E P LT+
Sbjct: 1002 NLGLSEMYFNYETKSALETLQEEKPELTV 1030
>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
sapiens]
Length = 1036
Score = 540 bits (1391), Expect = e-153
Identities = 347/1049 (33%), Positives = 537/1049 (51%), Gaps = 111/1049 (10%)
Query: 14 YLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWNITL 73
YLE+L+ + +KFK HL+ Q +P + +KA +LA L+I E++AW + +
Sbjct: 13 YLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAV 72
Query: 74 RIFQKMDRKDLCMKVMRE------------------------------------------ 91
IF ++R+DL K R+
Sbjct: 73 WIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKM 132
Query: 92 RTGYTKTYQAHAKQKF-------SRLWSSKSV----TEIHLYFEEEVKQEE--------- 131
+ Y K Y+ + + +F +RL S S+ T + L E +QE
Sbjct: 133 KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
Query: 132 ---CDH------LDRLFAPKEAGKQP-RTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDR 181
C+ ++ LF P + +P TV+ QG GIGKT L K+M+ W+ +++DR
Sbjct: 193 TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
Query: 182 FLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGLN 241
F Y FY CRE+ + SL DLI PDP PI +IV +P R+LF++D F+ELQG +
Sbjct: 253 FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
Query: 242 EPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRG 301
E LC D + +LLSSL+RKK+LPEASLLI +PV ++L+ + + G
Sbjct: 313 EHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILG 372
Query: 302 FNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDL 361
F+E+ R YF +F D +A AF+L++E+E LF++C IPL+CWI+CT LKQ+M+ GK L
Sbjct: 373 FSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSL 432
Query: 362 ALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLRR 421
A T ++TT+VY F+ +L P G H L LCSLAA+G+W F E DLR
Sbjct: 433 AQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAH-LWGLCSLAADGIWNQKILFEESDLRN 491
Query: 422 NGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDH----PHPAV 477
+G+ AD+ A L + K + E Y F+H+ QEF AA++YLL+ + P +
Sbjct: 492 HGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRL 551
Query: 478 RCVQE---LLVANFEKARRAHWIFLGCFLTGLLNKKEQEKLDAFFGFQLSQEIKQQIHQC 534
+ +L+ N+ K + + IF+ FL GL+N++ L+ ++SQ+I+ ++ +
Sbjct: 552 KLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKW 611
Query: 535 LKSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLK 594
++ + Q Q L +FYCL+EMQ+ FV++A++ + ++ +D +VS++C++
Sbjct: 612 IEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIE 671
Query: 595 YCSSLRKLCFSVQNVFKKEDEHSSTSDYSLICWHHICSVLTTSGHLRELQVQDSTLSEST 654
C + L + KE+E R L + L S+
Sbjct: 672 NCHRVESLSLGFLHNMPKEEEEEEKEG-------------------RHLDMVQCVLPSSS 712
Query: 655 FVTWCNQLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIRSL 714
+ L +N+ S LF VL L L + L +R L
Sbjct: 713 HAACSHGL-----------VNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVL 761
Query: 715 CDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQL-DTGVPLLCEA 773
C+ L +P N++ L L C LS C ++ +L++N+KL L++S N L D G+ LLC
Sbjct: 762 CETLQHPGCNIRRLWLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVG 821
Query: 774 LCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKH 833
L L L L C L+ CC+ ++ +L + S+ L + N L D G+ LCE K+
Sbjct: 822 LKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKN 881
Query: 834 PDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDC 893
P C L L LV +T+ C L+S L +NQNL L + N +GD G++LLC L H DC
Sbjct: 882 PQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDC 941
Query: 894 RLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQ 953
+L++L L+ C LTS CC DL+++LT S++L++L+L N L GV++ CE L+ C LQ
Sbjct: 942 KLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQ 1001
Query: 954 VLGLRKTDFDEETQALLTAEEERNPNLTI 982
LGL + F+ ET++ L +E P LT+
Sbjct: 1002 NLGLSEMYFNYETKSALETLQEEKPELTV 1030
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 539 bits (1388), Expect = e-153
Identities = 349/1052 (33%), Positives = 547/1052 (51%), Gaps = 85/1052 (8%)
Query: 11 LMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWN 70
L YLEEL+ E +KFK +L T +L +IPW ++KA E+A LLI H+ ++AW
Sbjct: 13 LSTYLEELEAVELKKFKLYLGTAT-ELGEGKIPWGSMEKAGPLEMAQLLITHFGPEEAWR 71
Query: 71 ITLRIFQKMDRKDLCMKVMRE-----------------------------RTGYTKTYQA 101
+ L F++++RKDL + RE R +TY+
Sbjct: 72 LALSTFERINRKDLWERGQREDLVRDTPPGGPSSLGNQSTCLLEVSLVTPRKDPQETYRD 131
Query: 102 HAKQKFSRLWSSKSV------------TEIHLYFEE----EVKQEECD------------ 133
+ ++KF RL ++ T + L E +V+Q+ D
Sbjct: 132 YVRRKF-RLMEDRNARLGECVNLSHRYTRLLLVKEHSNPMQVQQQLLDTGRGHARTVGHQ 190
Query: 134 ----HLDRLFAP-KEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYF 188
++ LF P +E + PRTV++QG GIGK+ L K+M+ W+D K+F+ RF Y FY
Sbjct: 191 ASPIKIETLFEPDEERPEPPRTVVMQGAAGIGKSMLAHKVMLDWADGKLFQGRFDYLFYI 250
Query: 189 CCRELRE-LPPTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGLNEPDSDL 247
CRE+ + S+ DLI WP+P+AP+ E++ PERLLF+ID F+EL+ ++P
Sbjct: 251 NCREMNQSATECSMQDLIFSCWPEPSAPLQELIRVPERLLFIIDGFDELKPSFHDPQGPW 310
Query: 248 CGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRGFNESDR 307
C EKRP ++LL+SL+RKK+LPE SLLI +P ++L + + GF+E++R
Sbjct: 311 CLCWEEKRPTELLLNSLIRKKLLPELSLLITTRPTALEKLHRLLEHPRHVEILGFSEAER 370
Query: 308 LVYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDLALTCQS 367
YF +F + ++A + FN VR++E LF++C +PL+CW++CT L+Q+++ G L T ++
Sbjct: 371 KEYFYKYFHNAEQAGQVFNYVRDNEPLFTMCFVPLVCWVVCTCLQQQLEGGGLLRQTSRT 430
Query: 368 TTSVYSSFVFNLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLRRNGVVDA 427
TT+VY ++ +L P+ P Q + LCSLAA+G+W F E DLR++G+
Sbjct: 431 TTAVYMLYLLSLMQPKPG-APRLQPPPNQRGLCSLAADGLWNQKILFEEQDLRKHGLDGE 489
Query: 428 DIPALLGTKILLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDHPHPAVRCVQELLVAN 487
D+ A L I K E Y F+H+ QEF AA++Y+L P + L+
Sbjct: 490 DVSAFLNMNIFQKDINCERYYSFIHLSFQEFFAAMYYILDEGEGGAGPDQDVTR--LLTE 547
Query: 488 FEKARRAHWIFLGCFLTGLLNKKEQEKLDAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQ 547
+ + R+ FL GLLN++ + L+ +++S IK + Q ++S + Q
Sbjct: 548 YAFSERSFLALTSRFLFGLLNEETRSHLEKSLCWKVSPHIKMDLLQWIQSKAQSDGSTLQ 607
Query: 548 VDSLAIFYCLFEMQDPAFVKQAVNLLQE-ANFHIIDNVDLVVSAYCLKYCSSLRKLCF-- 604
SL F CL+E+Q+ F++QA++ Q +I ++ +VS++CLK C S + L
Sbjct: 608 QGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQVLHLYG 667
Query: 605 SVQNVFKKEDEHSSTSDYSLICW------------HHICSVLTTSGHLRELQVQDSTLSE 652
+ + ++ S ++L+ H+ + L T+ +L EL + + L
Sbjct: 668 ATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGS 727
Query: 653 STFVTWCNQLRHPSCRLQKLGINNVSFSGQSVL-LFEVLFYQPDLKYLSFTLTKLSRDDI 711
C LRHP+C+LQ L + S + L L +L + + + +
Sbjct: 728 RGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGM 787
Query: 712 RSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQL-DTGVPLL 770
LC+ L +P ++ + L C L C+ +A +L N L L+++ N L D G+ LL
Sbjct: 788 MLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLL 847
Query: 771 CEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEA 830
C+ L P L L L C L+ C+ ++ L N+S+R LDLS N L D G+ LCE
Sbjct: 848 CQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEG 907
Query: 831 LKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTH 890
L+HP C L +L L C + +A CE L+ L +N NL+ L + N++GD G+ LL L H
Sbjct: 908 LRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQH 967
Query: 891 TDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPEC 950
CRL+ L L+ CGLT+ C++L L ++TL L LT N L TGV +LC+ L HP C
Sbjct: 968 PACRLQKLWLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGC 1027
Query: 951 ALQVLGLRKTDFDEETQALLTAEEERNPNLTI 982
L+VL L D ++ T + L A P L I
Sbjct: 1028 KLRVLWLFGMDLNKMTHSRLAALRVTKPYLDI 1059
Score = 100 bits (249), Expect = 7e-21
Identities = 50/131 (38%), Positives = 82/131 (62%)
Query: 854 EDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDL 913
E LA+AL +N NL L + N +G GV+LLC+ L H +C+L+ L L+ C ++S+ C+DL
Sbjct: 703 EHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDL 762
Query: 914 ASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAE 973
++ L +K L +++L+ N + G+++LCE LRHP+C LQ++ LRK + + +
Sbjct: 763 SAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASV 822
Query: 974 EERNPNLTITD 984
NP+L D
Sbjct: 823 LGTNPHLVELD 833
Score = 48.1 bits (113), Expect = 4e-05
Identities = 35/100 (35%), Positives = 46/100 (46%), Gaps = 3/100 (3%)
Query: 885 CRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEA 944
C A HT L + E L + LA+ L + L +L+L N L GV +LC+
Sbjct: 680 CSAGAHT---LLVQLPERTVLLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQG 736
Query: 945 LRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITD 984
LRHP C LQ L L++ L+A N NLT D
Sbjct: 737 LRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMD 776
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 525 bits (1353), Expect = e-149
Identities = 318/877 (36%), Positives = 483/877 (55%), Gaps = 12/877 (1%)
Query: 89 MRERTGYTKTYQAHAKQKFSRLWSSKSVTEIHLYFEEEVKQEECDHLDRLFAPKEAGKQP 148
M E + + Y+ + K + W + S + H+Y K E + L RL P Q
Sbjct: 170 MLEEADHRRKYRENMKAELLETWDNISWPKDHVYIRNTSKDEH-EELQRLLDPNRTRAQA 228
Query: 149 RTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELPPTSLADLISRE 208
+T+++ G G+GKTTL M+ M+ W++ +F+ RF Y FY C ++R + T+ A+LIS +
Sbjct: 229 QTIVLVGRAGVGKTTLAMQAMLHWANGVLFQQRFSYVFYLSCHKIRYMKETTFAELISLD 288
Query: 209 WPDPAAPITEIVSQPERLLFVIDSFEEL----QGGLNEPDSDLCGDLMEKRPVQVLLSSL 264
WPD API E +SQPE+LLF+ID FEE+ + D C D ++ PV +L SL
Sbjct: 289 WPDFDAPIEEFMSQPEKLLFIIDGFEEIIISESRSESLDDGSPCTDWYQELPVTKILHSL 348
Query: 265 LRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRGFNESDRLVYFCCFFKDPKRAMEA 324
L+K+++P A+LLI IK ++L+ + Q GF D VYF F D +
Sbjct: 349 LKKELVPLATLLITIKTWFVRDLKASLVNPCFVQITGFTGDDLRVYFMRHFDDSSEVEKI 408
Query: 325 FNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVFNLFTPEG 384
+R++E LF C P++CW +C+ LKQ + DL Q+TTS+Y+ F NLF+
Sbjct: 409 LQQLRKNETLFHSCSAPMVCWTVCSCLKQPKVRYYDLQSITQTTTSLYAYFFSNLFSTAE 468
Query: 385 AEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKILLKYGER 444
+ Q +ALCSLA EG+W+ F F ++D G+ I +L IL K +
Sbjct: 469 VDLADDSWPGQWRALCSLAIEGLWSMNFTFNKEDTEIEGLEVPFIDSLYEFNILQKINDC 528
Query: 445 ESSYVFLHVCIQEFCAALFYLLKSHLDH-PHPAVRCVQELLVANFEKARRAHWIFLGCFL 503
F H+ QEF AA+ ++L+ + PH ++L+ + + A+W + F
Sbjct: 529 GGCTTFTHLSFQEFFAAMSFVLEEPREFPPHSTKPQEMKMLLQHVLLDKEAYWTPVVLFF 588
Query: 504 TGLLNKKEQEKLDAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQVDSLAIFYCLFEMQDP 563
GLLNK +L+ ++S + +++ + + LG+ + Q L +F+CL E Q+
Sbjct: 589 FGLLNKNIARELEDTLHCKISPRVMEELLKWGEELGKAESASLQFHILRLFHCLHESQEE 648
Query: 564 AFVKQAVNLLQEANFHIIDNVDLVVSAYCLKYCSSLRKLCFSV-QNVFKKEDEHSSTS-- 620
F K+ + + E + +I+++ +L S++CLK+C L KL SV ++ +++ E TS
Sbjct: 649 DFTKKMLGRIFEVDLNILEDEELQASSFCLKHCKRLNKLRLSVSSHILERDLEILETSKF 708
Query: 621 DYSLICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFS 680
D + W+ ICS L T+ +L EL + +S L S+ C L++P C++QKL +V+
Sbjct: 709 DSRMHAWNSICSTLVTNENLHELDLSNSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPE 768
Query: 681 GQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDC 740
L L L +L+F+ KL + + AL + A N+K L L C+LS C
Sbjct: 769 WVLQDLIIALQGNSKLTHLNFSSNKLGM-TVPLILKALRHSACNLKYLCLEKCNLSAASC 827
Query: 741 EVLAGLLTNNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYI 799
+ LA LT+ + +T L + N+L D G+ LLC AL P L L L FC L+ C+++
Sbjct: 828 QDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHL 887
Query: 800 SEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASA 859
S+ LL+N+S+ +L+LS N L+DEG+K LCEAL PD L SL L C T GC +LA+A
Sbjct: 888 SDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANA 947
Query: 860 LISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTC 919
L N N+KIL +G N++ D GV+LLC AL L LGL +C LT+ CC+ L SVL+
Sbjct: 948 LSHNHNVKILDLGENDLQDDGVKLLCEAL-KPHRALHTLGLAKCNLTTACCQHLFSVLSS 1006
Query: 920 SKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLG 956
SK+L LNL N LD GV +LC+AL+ C LQ LG
Sbjct: 1007 SKSLVNLNLLGNELDTDGVKMLCKALKKSTCRLQKLG 1043
Score = 52.8 bits (125), Expect = 2e-06
Identities = 37/134 (27%), Positives = 59/134 (44%), Gaps = 7/134 (5%)
Query: 10 GLMWYLEELKKEEFRKFKEHLKQMTL-------QLELKQIPWTEVKKASREELANLLIKH 62
GL+ YL L + + +FK L+ L Q +IPW ++ A L+ LL +H
Sbjct: 16 GLLPYLMALDQYQLEEFKLCLEPQQLMDFWSAPQGHFPRIPWANLRAADPLNLSFLLDEH 75
Query: 63 YEEQQAWNITLRIFQKMDRKDLCMKVMRERTGYTKTYQAHAKQKFSRLWSSKSVTEIHLY 122
+ + QAW + L IFQ M+ LC KV E +T + + + +
Sbjct: 76 FPKGQAWKVVLGIFQTMNLTSLCEKVRAEMKENVQTQELQDPTQEDLEMLEAAAGNMQTQ 135
Query: 123 FEEEVKQEECDHLD 136
++ QEE D L+
Sbjct: 136 GCQDPNQEELDELE 149
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 501 bits (1289), Expect = e-141
Identities = 346/1060 (32%), Positives = 530/1060 (50%), Gaps = 95/1060 (8%)
Query: 1 MAASFFSDFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLI 60
M +S F L LE+L ++E KFK + +L EL++IP EV KA ++L +L
Sbjct: 1 MVSSAQMGFNLQALLEQLSQDELSKFKYLITTFSLAHELQKIPHKEVDKADGKQLVEILT 60
Query: 61 KHYEEQQAWNITLRIFQ---KMD-------------------RKDLCMKVMR-------- 90
H + +L++F+ +MD RK L + + R
Sbjct: 61 THCDSYWVEMASLQVFEKMHRMDLSERAKDEVREAALKSFNKRKPLSLGITRKERPPLDV 120
Query: 91 ---------ERTGYTKTY----------------------QAHAKQKFSRLWSSKSVTEI 119
E +T+T + K KF +W S
Sbjct: 121 DEMLERFKTEAQAFTETKGNVICLGKEVFKGKKPDKDNRCRYILKTKFREMWKSWPGDSK 180
Query: 120 HLYFEEEVKQEECDHLDRLFAPKEA-GKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIF 178
E +V E L P+ G TV++ GP G+GKTTL KLM+ W+++ +
Sbjct: 181 ----EVQVMAERYKMLIPFSNPRVLPGPFSYTVVLYGPAGLGKTTLAQKLMLDWAEDNLI 236
Query: 179 RDRFLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQG 238
+F Y FY CREL L P S A+L+ R+WP+ I I++Q ++LFVID F+EL
Sbjct: 237 H-KFKYAFYLSCRELSRLGPCSFAELVFRDWPELQDDIPHILAQARKILFVIDGFDELGA 295
Query: 239 GLNEPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQ 298
D+CGD +K+PV VLL SLL + MLP+A+LL+ +P ++LR +
Sbjct: 296 APGALIEDICGDWEKKKPVPVLLGSLLNRVMLPKAALLVTTRPRALRDLRILAEEPIYIR 355
Query: 299 PRGFNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKG 358
GF E DR YF F D +AM AF L+R + LF + P +CWI+CT+LK +M+KG
Sbjct: 356 VEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGSAPAVCWIVCTTLKLQMEKG 415
Query: 359 KDLALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDD 418
+D TC + T ++ F+ + F P+GA Q + L+ L LAA+G+W T +D
Sbjct: 416 EDPVPTCLTRTGLFLRFLCSRF-PQGA-----QLRGALRTLSLLAAQGLWAQTSVLHRED 469
Query: 419 LRRNGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDHPHPA-- 476
L R GV ++D+ L IL + + Y F+H+ Q+F ALFY L+ +
Sbjct: 470 LERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFLTALFYTLEKEEEEDRDGHT 529
Query: 477 --VRCVQELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKLDAFFGFQLSQEIKQQIHQC 534
+ VQ+LL + E+ R I G + GL N+K ++L+A FG ++S +IKQ++ +C
Sbjct: 530 WDIGDVQKLL-SGVERLRNPDLIQAGYYSFGLANEKRAKELEATFGCRMSPDIKQELLRC 588
Query: 535 LKSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLK 594
+ +G D + CL+E Q+ VK+ + +E + H+ + VD+V S++C+K
Sbjct: 589 --DISCKGGHSTVTDLQELLGCLYESQEEELVKEVMAQFKEISLHL-NAVDVVPSSFCVK 645
Query: 595 YCSSLRKLCFSV------QNVFKKED----EHSSTSDYSLICWHHICSVLTTSGHLRELQ 644
+C +L+K+ V +NV E E S + L W +CS+ ++ L L
Sbjct: 646 HCRNLQKMSLQVIKENLPENVTASESDAEVERSQDDQHMLPFWTDLCSIFGSNKDLMGLA 705
Query: 645 VQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQPDLKYLSFTLT 704
+ DS LS S C Q+ +C LQ++ N+S + L L + YL TL
Sbjct: 706 INDSFLSASLVRILCEQIASDTCHLQRVVFKNISPADAHRNLCLALRGHKTVTYL--TLQ 763
Query: 705 KLSRDDI-RSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQL 763
+DD+ +LC+ L +P N++ L LV+C + L+ L N+ LT +N+S N+L
Sbjct: 764 GNDQDDMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNEL 823
Query: 764 -DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDE 822
D G LL L P L L L CHL+E C+ ++ +L+ ++ + +L L+ N + +
Sbjct: 824 LDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNT 883
Query: 823 GLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQ 882
G+K LCE L++P+C L +L L C IT+ GC DL L +L L +G N IG G++
Sbjct: 884 GVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMK 943
Query: 883 LLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLC 942
LC AL C L L L C + C+DL S L+C+++L L+L N L +GV +L
Sbjct: 944 FLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLF 1003
Query: 943 EALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTI 982
E L L+ L L+ DF++E LL EE+NP L I
Sbjct: 1004 ETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEEKNPQLII 1043
Score = 129 bits (325), Expect = 1e-29
Identities = 94/252 (37%), Positives = 123/252 (48%), Gaps = 21/252 (8%)
Query: 743 LAGLLTNNKKLTYLNVSCNQLDTG-VPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISE 801
L + +NK L L ++ + L V +LCE + S DT CHL + IS
Sbjct: 691 LCSIFGSNKDLMGLAINDSFLSASLVRILCEQIAS-DT---------CHLQRVVFKNISP 740
Query: 802 M---------LLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAG 852
L +K+V YL L N +D+ LCE L+HP+C L L LV C T
Sbjct: 741 ADAHRNLCLALRGHKTVTYLTLQGND-QDDMFPALCEVLRHPECNLRYLGLVSCSATTQQ 799
Query: 853 CEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKD 912
DL+ AL NQ+L + + NE+ D G +LL L H C L+ L LE C LT CKD
Sbjct: 800 WADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKD 859
Query: 913 LASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTA 972
LA+VL S+ L L L N + +TGV LCE LR+PEC LQ L L D + LT
Sbjct: 860 LAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTK 919
Query: 973 EEERNPNLTITD 984
+ +L D
Sbjct: 920 LLQEKSSLLCLD 931
Score = 49.7 bits (117), Expect = 1e-05
Identities = 41/133 (30%), Positives = 60/133 (45%), Gaps = 2/133 (1%)
Query: 855 DLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLA 914
DL S SN++L L I + + V++LC + C L+ + + + ++L
Sbjct: 690 DLCSIFGSNKDLMGLAINDSFLSASLVRILCEQIASDTCHLQRVVFKNIS-PADAHRNLC 748
Query: 915 SVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEE 974
L KT+ L L N D LCE LRHPEC L+ LGL + A L+
Sbjct: 749 LALRGHKTVTYLTLQGNDQDDM-FPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLAL 807
Query: 975 ERNPNLTITDDCD 987
E N +LT + D
Sbjct: 808 EVNQSLTCVNLSD 820
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 487 bits (1254), Expect = e-137
Identities = 305/965 (31%), Positives = 486/965 (50%), Gaps = 87/965 (9%)
Query: 94 GYTKTYQAHAKQKFSRLWSSKSVTEIHLYFEEEVKQ-EECDHLDRLFAPKEAGKQPRTVI 152
G T Y++H KF+ ++ FE E L F G +PRTV+
Sbjct: 230 GDTWDYKSHVMTKFAE------EEDVRRSFENTAADWPEMQTLAGAFDSDRWGFRPRTVV 283
Query: 153 IQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELPPTSLADLISREWPDP 212
+ G GIGK+ L ++++ W+ +++ F Y F+ RE++ +S+ + ISREWPD
Sbjct: 284 LHGKSGIGKSALARRIVLCWAQGGLYQGMFSYVFFLPVREMQRKKESSVTEFISREWPDS 343
Query: 213 AAPITEIVSQPERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPVQVLLSSLLRKKMLPE 272
AP+TEI+S+PERLLF+ID F++L LN D+ LC D EK+P L+ SLLRK +LPE
Sbjct: 344 QAPVTEIMSRPERLLFIIDGFDDLGSVLNN-DTKLCKDWAEKQPPFTLIRSLLRKVLLPE 402
Query: 273 ASLLIAIKPVCPKELRDQVTISEIYQPRGFNESDRLVYFCCFFKDPKRAMEAFNLVRESE 332
+ L++ ++ V ++L+ +V RG + R+ + + + +
Sbjct: 403 SFLIVTVRDVGTEKLKSEVVSPRYLLVRGISGEQRIHLLLERGIGEHQKTQGLRAIMNNR 462
Query: 333 QLFSICQIPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVFNLFTPEGAEGPTPQT 392
+L CQ+P + ++C +L+ + G+ +A Q+ T ++++FVF+ TP G
Sbjct: 463 ELLDQCQVPAVGSLICVALQLQDVVGESVAPFNQTLTGLHAAFVFHQLTPRGVVRRCLNL 522
Query: 393 QHQ--LKALCSLAAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKILLKYGERESSYVF 450
+ + LK C +A EG+W F DDL G+ ++++ AL ILL E Y F
Sbjct: 523 EERVVLKRFCRMAVEGVWNRKSVFDGDDLMVQGLGESELRALFHMNILLPDSHCEEYYTF 582
Query: 451 LHVCIQEFCAALFYLLKSHLDHPHPAVRCVQ------ELLVANFEKARRAHWIFLGCFLT 504
H+ +Q+FCAAL+Y+L+ P V+ EL A F H +++ FL
Sbjct: 583 FHLSLQDFCAALYYVLEGLEIEPALCPLYVEKTKRSMELKQAGF----HIHSLWMKRFLF 638
Query: 505 GLLNKKEQEKLDAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQVDSLAIFYCLFEMQDPA 564
GL+++ + L+ G + +KQ++ + LG++ N D+L F+CLFE QD
Sbjct: 639 GLVSEDVRRPLEVLLGCPVPLGVKQKLLHWVSLLGQQPNATTPGDTLDAFHCLFETQDKE 698
Query: 565 FVKQAVNLLQEANFHIIDNVDLVVSAYCLKYCSSLRKLCFSVQNVFKKEDEHSS------ 618
FV+ A+N QE I N+DL+ S++CL++C LRK+ V+ +F +++ +
Sbjct: 699 FVRLALNSFQEVWLPINQNLDLIASSFCLQHCPYLRKIRVDVKGIFPRDESAEACPVVPL 758
Query: 619 -TSDYSLI--CWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGIN 675
D +LI W CS+L T HLR+L + S L+E T C +LRHP+C++Q L
Sbjct: 759 WMRDKTLIEEQWEDFCSMLGTHPHLRQLDLGSSILTERAMKTLCAKLRHPTCKIQTLMFR 818
Query: 676 NVSFSGQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYP-------------- 721
N + L+ ++ +L+ L+ T L +D+R C+AL +P
Sbjct: 819 NAQITPGVQHLWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGL 878
Query: 722 -----------------------AGN--------------------VKELALVNCHLSPI 738
AGN +++L L +C ++
Sbjct: 879 THACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITAT 938
Query: 739 DCEVLAGLLTNNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCE 797
C+ LA L +N+ LT+L +S N L + GV LLC ++ P L LML CHL C
Sbjct: 939 GCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCG 998
Query: 798 YISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLA 857
+++ L+ N + +L LS N ++D G+K LCE ++ P C L L LVKC +TAA CE L+
Sbjct: 999 FLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLS 1058
Query: 858 SALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVL 917
+ +++LK L + N +GD GV LC L + L LGL+ CGLTS CC+ L+ L
Sbjct: 1059 CVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLAL 1118
Query: 918 TCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERN 977
+C++ L LNL N G++ LC A P LQ++GL K + + + LL +
Sbjct: 1119 SCNRHLTSLNLVQNNFSPKGMMKLCSAFACPTSNLQIIGLWKWQYPVQIRKLLEEVQLLK 1178
Query: 978 PNLTI 982
P + I
Sbjct: 1179 PRVVI 1183
Score = 62.8 bits (151), Expect = 2e-09
Identities = 39/108 (36%), Positives = 58/108 (53%), Gaps = 7/108 (6%)
Query: 6 FSDFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEE 65
FS +GL W L EL KEEF+ FKE LK+ + + IP E++ A+ E LA LL ++Y
Sbjct: 60 FSSYGLQWCLYELDKEEFQTFKELLKKKSSESTTCSIPQFEIENANVECLALLLHEYYGA 119
Query: 66 QQAWNITLRIFQKMDRKDLCMKVMRERTGY-------TKTYQAHAKQK 106
AW ++ IF+ M+ + L K + + T T Q +K+K
Sbjct: 120 SLAWATSISIFENMNLRTLSEKARDDMKRHSPEDPEATMTDQGPSKEK 167
>gi|33667040 NLR family, pyrin domain containing 8 [Homo sapiens]
Length = 1048
Score = 477 bits (1227), Expect = e-134
Identities = 312/973 (32%), Positives = 495/973 (50%), Gaps = 46/973 (4%)
Query: 10 GLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAW 69
G+M Y+ + EE ++FK+ L L I W +V+ AS E+ +LLI+ + ++AW
Sbjct: 40 GVMLYMRNVSHEELQRFKQ-LLLTELSTGTMPITWDQVETASWAEVVHLLIERFPGRRAW 98
Query: 70 NITLRIFQKMDRKDLCMKVMRE-------------------------RTGYTKTYQAHAK 104
++T IF M+ +C+ V RE +G + Y+++
Sbjct: 99 DVTSNIFAIMNCDKMCVVVRREINAILPTLEPEDLNVGETQVNLEEGESGKIRRYKSNVM 158
Query: 105 QKFSRLWSSKSVTEIHL-YFEEEVKQEECDHLDRLFAPKEA-GKQPRTVIIQGPQGIGKT 162
+KF +W + +F + V + E ++L L PK G+QP+TV IQG GIGKT
Sbjct: 159 EKFFPIWDITTWPGNQRDFFYQGVHRHE-EYLPCLLLPKRPQGRQPKTVAIQGAPGIGKT 217
Query: 163 TLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQ 222
L K+M W+ NK + + FYF C+E+ + S ++LI ++WP +++I+S+
Sbjct: 218 ILAKKVMFEWARNKFYAHKRWCAFYFHCQEVNQTTDQSFSELIEQKWPGSQDLVSKIMSK 277
Query: 223 PERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPV 282
P++LL ++D FEEL L + DL D +K P VLLSSLL K MLPEA+LLI I+
Sbjct: 278 PDQLLLLLDGFEELTSTLIDRLEDLSEDWRQKLPGSVLLSSLLSKTMLPEATLLIMIRFT 337
Query: 283 CPKELRDQVTISEIYQPRGFNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPL 342
+ + + + GFN +++ YF +F + + + E+ LFS+C++P+
Sbjct: 338 SWQTCKPLLKCPSLVTLPGFNTMEKIKYFQMYFGHTEEGDQVLSFAMENTILFSMCRVPV 397
Query: 343 LCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKALCSL 402
+CW++C+ LKQ+M++G +L +C + TSV+ ++ +LF Q QL+ LC L
Sbjct: 398 VCWMVCSGLKQQMERGNNLTQSCPNATSVFVRYISSLFPTRAENFSRKIHQAQLEGLCHL 457
Query: 403 AAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAAL 462
AA+ MW + ++DL + + A LG IL + E YVF V QEF AAL
Sbjct: 458 AADSMWHRKWVLGKEDLEEAKLDQTGVTAFLGMSILRRIAGEEDHYVFTLVTFQEFFAAL 517
Query: 463 FYLL--KSHLDHPHPAVRCVQELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKLDAFFG 520
FY+L L + H + L+A+ + +++ +G FL G LN+ ++ F
Sbjct: 518 FYVLCFPQRLKNFHVLSHVNIQRLIAS-PRGSKSYLSHMGLFLFGFLNEACASAVEQSFQ 576
Query: 521 FQLSQEIKQQIHQCLKSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQEANFHI 580
++S K+++ + + L + P +FYCL E+++ AFV QA+N + I
Sbjct: 577 CKVSFGNKRKLLKVIPLLHKCDPPSPGSGVPQLFYCLHEIREEAFVSQALNDYHKVVLRI 636
Query: 581 IDNVDLVVSAYCLKYCSSLRKLCFSVQNVFKKEDEHSSTSDYSLIC---------WHHIC 631
+N ++ VSA+CLK C L ++ +V F + SS+S W +C
Sbjct: 637 GNNKEVQVSAFCLKRCQYLHEVELTVTLNFMNVWKLSSSSHPGSEAPESNGLHRWWQDLC 696
Query: 632 SVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSVLLFEVLF 691
SV T+ L L + +S L LRHP C+LQKL + V+ + + L VL
Sbjct: 697 SVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLIGVLT 756
Query: 692 YQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNK 751
L+YL ++ ++ LC L P ++ L L +C +P L L N
Sbjct: 757 GNQHLRYLEIQHVEVESKAVKLLCRVLRSPRCRLQCLRLEDCLATPRIWTDLGNNLQGNG 816
Query: 752 KLTYLNVSCNQLDTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRY 811
L L + N L+ C A L L + C+L++ CE ++ L ++K + +
Sbjct: 817 HLKTLILRKNSLEN-----CGAYYLSVAQLERLSIENCNLTQLTCESLASCLRQSKMLTH 871
Query: 812 LDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQI 871
L L+ N LKDEG K + AL H C L L L KC +T C+D+ SAL N+ LK L +
Sbjct: 872 LSLAENALKDEGAKHIWNALPHLRCPLQRLVLRKCDLTFNCCQDMISALCKNKTLKSLDL 931
Query: 872 GCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLN 931
N + D GV LLC AL + DC L+IL LE C TS CC+ +AS+L ++ L+ L+L+ N
Sbjct: 932 SFNSLKDDGVILLCEALKNPDCTLQILELENCLFTSICCQAMASMLRKNQHLRHLDLSKN 991
Query: 932 TLDHTGVVVLCEA 944
+ G++ LCEA
Sbjct: 992 AIGVYGILTLCEA 1004
Score = 38.1 bits (87), Expect = 0.041
Identities = 22/60 (36%), Positives = 32/60 (53%)
Query: 911 KDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALL 970
+DL SV + L+ L +T + L + L ALRHP+C LQ L LR+ + Q L+
Sbjct: 693 QDLCSVFATNDKLEVLTMTNSVLGPPFLKALAAALRHPQCKLQKLLLRRVNSTMLNQDLI 752
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7 isoform
3 [Homo sapiens]
Length = 1037
Score = 474 bits (1220), Expect = e-133
Identities = 336/1048 (32%), Positives = 530/1048 (50%), Gaps = 99/1048 (9%)
Query: 8 DFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQ 67
++ L LE+L ++E + FK L L+ L++ PW+EV++A ++LA +L+ E
Sbjct: 7 EWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENW 66
Query: 68 AWNITLRIFQKMDRKDLCMKVMRE-------------RTGYTKTYQAHAKQKFSRLWSSK 114
N T+ I ++M+ +LC E G + AK W +
Sbjct: 67 IRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWRN- 125
Query: 115 SVTEIHLYFEEEVKQEECDHL-------DRLFAPKEAGKQPR-----TVIIQGPQGIGKT 162
S+ + L ++ Q + D+ ++ F P + PR TV++ GP G+GKT
Sbjct: 126 SMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKT 185
Query: 163 TLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQ 222
TL K M+ W+D + Y FY C+EL + P S A+LIS++WP+ I I++Q
Sbjct: 186 TLAKKCMLDWTDCNL-SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQ 244
Query: 223 PERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPV 282
+R+LFV+D +EL+ D+CGD +K+PV VLL SLL++KMLP A+LL+ +
Sbjct: 245 AQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTR-- 302
Query: 283 CPKELRDQVTISE--IY-QPRGFNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQ 339
P+ LRD +++ IY + GF E DR YF F D +AM AF L+R + LF +
Sbjct: 303 -PRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGS 361
Query: 340 IPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKAL 399
P +CWI+CT+LK +M+KG+D TC + T ++ F+ + F P+GA Q + L+ L
Sbjct: 362 APAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRF-PQGA-----QLRGALRTL 415
Query: 400 CSLAAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFC 459
LAA+G+W F +DL R GV ++D+ L IL + + Y F+H+ Q+F
Sbjct: 416 SLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFL 475
Query: 460 AALFYLLKSHLDHPHPA----VRCVQELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKL 515
ALFY L+ + VQ+LL + E+ + I +G FL GL N+K ++L
Sbjct: 476 TALFYALEKEEGEDRDGHAWDIGDVQKLL-SGEERLKNPDLIQVGHFLFGLANEKRAKEL 534
Query: 516 DAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQE 575
+A FG ++S +IKQ++ QC L P D + CL+E Q+ K V +E
Sbjct: 535 EATFGCRMSPDIKQELLQCKAHL-HANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKE 593
Query: 576 ANFHIIDNVDLVVSAYCLKYCSSLRKLCFSV-QNVFKKE------DEHSSTSDY------ 622
+ H+ + +++ ++ LK+C L+KL V + VF + D Y
Sbjct: 594 ISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLENYMDFELDIEFERCTYLTIPNW 653
Query: 623 ------SLICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINN 676
SL W CS+ +++ +L+ L+V+ S LS+S+ C+ + +C LQK+ I N
Sbjct: 654 ARQDLRSLRLWTDFCSLFSSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKN 713
Query: 677 VSFSGQSVLLFEVLFYQPDLKYLSF--------TLTKLS--------RDDIRSLCDALNY 720
V+ PD Y F TLT L+ R + LCD L
Sbjct: 714 VT---------------PDTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRN 758
Query: 721 PAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCN-QLDTGVPLLCEALCSPDT 779
N++ L L +P +L N+ L +L +S N LD G LL + + P
Sbjct: 759 HKCNLQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKH 818
Query: 780 VLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLD 839
L L L C L+E C+ ++ +L+ +K + +L L+ N + D G+K LCE L +PDC L
Sbjct: 819 FLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQ 878
Query: 840 SLCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILG 899
+L L +C IT GC L+ AL +L L + N+I G+ +LC+AL + +C L+ L
Sbjct: 879 TLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLR 937
Query: 900 LEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRK 959
L C L C+ L S L ++ L+ L+L N L +G++ L LR +L++L L+
Sbjct: 938 LWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKT 997
Query: 960 TDFDEETQALLTAEEERNPNLTITDDCD 987
+ + E + LL +E+NP LTI DC+
Sbjct: 998 YETNLEIKKLLEEVKEKNPKLTI--DCN 1023
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform
1 [Homo sapiens]
Length = 1009
Score = 466 bits (1200), Expect = e-131
Identities = 331/1030 (32%), Positives = 526/1030 (51%), Gaps = 91/1030 (8%)
Query: 8 DFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQ 67
++ L LE+L ++E + FK L L+ L++ PW+EV++A ++LA +L+ E
Sbjct: 7 EWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENW 66
Query: 68 AWNITLRIFQKMDRKDLCMKVMRE-------------RTGYTKTYQAHAKQKFSRLWSSK 114
N T+ I ++M+ +LC E G + AK W +
Sbjct: 67 IRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWRN- 125
Query: 115 SVTEIHLYFEEEVKQEECDHL-------DRLFAPKEAGKQPR-----TVIIQGPQGIGKT 162
S+ + L ++ Q + D+ ++ F P + PR TV++ GP G+GKT
Sbjct: 126 SMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKT 185
Query: 163 TLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQ 222
TL K M+ W+D + Y FY C+EL + P S A+LIS++WP+ I I++Q
Sbjct: 186 TLAKKCMLDWTDCNL-SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQ 244
Query: 223 PERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPV 282
+R+LFV+D +EL+ D+CGD +K+PV VLL SLL++KMLP A+LL+ +
Sbjct: 245 AQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTR-- 302
Query: 283 CPKELRDQVTISE--IY-QPRGFNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQ 339
P+ LRD +++ IY + GF E DR YF F D +AM AF L+R + LF +
Sbjct: 303 -PRALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGS 361
Query: 340 IPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKAL 399
P +CWI+CT+LK +M+KG+D TC + T ++ F+ + F P+GA Q + L+ L
Sbjct: 362 APAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRF-PQGA-----QLRGALRTL 415
Query: 400 CSLAAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFC 459
LAA+G+W F +DL R GV ++D+ L IL + + Y F+H+ Q+F
Sbjct: 416 SLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFL 475
Query: 460 AALFYLLKSHLDHPHPA----VRCVQELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKL 515
ALFY L+ + VQ+LL + E+ + I +G FL GL N+K ++L
Sbjct: 476 TALFYALEKEEGEDRDGHAWDIGDVQKLL-SGEERLKNPDLIQVGHFLFGLANEKRAKEL 534
Query: 516 DAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQE 575
+A FG ++S +IKQ++ QC L P D + CL+E Q+ K V +E
Sbjct: 535 EATFGCRMSPDIKQELLQCKAHL-HANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKE 593
Query: 576 ANFHIIDNVDLVVSAYCLKYCSSLRKLCFSV-QNVFKKEDEHSSTSDYSLICWHHICSVL 634
+ H+ + +++ ++ LK+C L+KL V + VF + + D+ L
Sbjct: 594 ISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLE-----NYMDFEL-----DIEFE 643
Query: 635 TTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQP 694
+++ +L+ L+V+ S LS+S+ C+ + +C LQK+ I NV+ P
Sbjct: 644 SSNSNLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVT---------------P 688
Query: 695 DLKYLSF--------TLTKLS--------RDDIRSLCDALNYPAGNVKELALVNCHLSPI 738
D Y F TLT L+ R + LCD L N++ L L +P
Sbjct: 689 DTAYRDFCLAFIGKKTLTHLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPE 748
Query: 739 DCEVLAGLLTNNKKLTYLNVSCN-QLDTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCE 797
+L N+ L +L +S N LD G LL + + P L L L C L+E C+
Sbjct: 749 QWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCK 808
Query: 798 YISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLA 857
++ +L+ +K + +L L+ N + D G+K LCE L +PDC L +L L +C IT GC L+
Sbjct: 809 DLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLS 868
Query: 858 SALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVL 917
AL +L L + N+I G+ +LC+AL + +C L+ L L C L C+ L S L
Sbjct: 869 EALQEACSLTNLDLSINQIAR-GLWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSAL 927
Query: 918 TCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERN 977
++ L+ L+L N L +G++ L LR +L++L L+ + + E + LL +E+N
Sbjct: 928 LSNQKLETLDLGQNHLWKSGIIKLFGVLRQRTGSLKILRLKTYETNLEIKKLLEEVKEKN 987
Query: 978 PNLTITDDCD 987
P LTI DC+
Sbjct: 988 PKLTI--DCN 995
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 462 bits (1189), Expect = e-130
Identities = 307/945 (32%), Positives = 472/945 (49%), Gaps = 116/945 (12%)
Query: 14 YLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWNITL 73
YLE+L+ + +KFK HL+ Q +P + +KA +LA L+I E++AW + +
Sbjct: 13 YLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAV 72
Query: 74 RIFQKMDRKDLCMKVMRE------------------------------------------ 91
IF ++R+DL K R+
Sbjct: 73 WIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKM 132
Query: 92 RTGYTKTYQAHAKQKF-------SRLWSSKSV----TEIHLYFEEEVKQEE--------- 131
+ Y K Y+ + + +F +RL S S+ T + L E +QE
Sbjct: 133 KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
Query: 132 ---CDH------LDRLFAPKEAGKQP-RTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDR 181
C+ ++ LF P + +P TV+ QG GIGKT L K+M+ W+ +++DR
Sbjct: 193 TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
Query: 182 FLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGLN 241
F Y FY CRE+ + SL DLI PDP PI +IV +P R+LF++D F+ELQG +
Sbjct: 253 FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
Query: 242 EPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRG 301
E LC D + +LLSSL+RKK+LPEASLLI +PV ++L+ + + G
Sbjct: 313 EHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILG 372
Query: 302 FNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDL 361
F+E+ R YF +F D +A AF+L++E+E LF++C IPL+CWI+CT LKQ+M+ GK L
Sbjct: 373 FSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSL 432
Query: 362 ALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLRR 421
A T ++TT+VY F+ +L P G H L LCSLAA+G+W F E DLR
Sbjct: 433 AQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAH-LWGLCSLAADGIWNQKILFEESDLRN 491
Query: 422 NGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAALFYLLK-----------SHL 470
+G+ AD+ A L + K + E Y F+H+ QEF AA++YLL+ S L
Sbjct: 492 HGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRL 551
Query: 471 DHPHPAVRCVQELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKLDAFFGFQLSQEIKQQ 530
P V +L+ N+ K + + IF+ FL GL+N++ L+ ++SQ+I+ +
Sbjct: 552 KLPSRDV----TVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLE 607
Query: 531 IHQCLKSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSA 590
+ + ++ + Q Q L +FYCL+EMQ+ FV++A++ + ++ +D +VS+
Sbjct: 608 LLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSS 667
Query: 591 YCLKYCSSLRKLCFSVQNVFKKEDEHSS-------------TSDYSLICWHHIC------ 631
+C++ C + L + KE+E S C H +
Sbjct: 668 FCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLVNSHLTS 727
Query: 632 -------SVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSV 684
SVL+TS L EL + D++L + C L+HP C +++L + S +
Sbjct: 728 SFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECC 787
Query: 685 L-LFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVL 743
+ VL L L + L IR LC L + N+K+L LVN L+ + C L
Sbjct: 788 FDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSAL 847
Query: 744 AGLLTNNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEM 802
+ +L+ N+ LT+L + N L D G+ LLCE L PD L L L C+L+ CC +S +
Sbjct: 848 SSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 907
Query: 803 LLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCF 847
L ++S+R L L N L D G+ CE LK C L +L L + +
Sbjct: 908 LTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMY 952
Score = 195 bits (495), Expect = 2e-49
Identities = 109/254 (42%), Positives = 154/254 (60%), Gaps = 1/254 (0%)
Query: 730 LVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAF 788
LVN HL+ C L +L+ ++ LT L++S N L D G+ +LCE L P + L L
Sbjct: 720 LVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGR 779
Query: 789 CHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFI 848
C LS +CC IS +L N+ + LDLS N L D G++ LC LKH C L L LV +
Sbjct: 780 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGL 839
Query: 849 TAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTST 908
T+ C L+S L +NQNL L + N +GD G++LLC L H DC+L++L L+ C LTS
Sbjct: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 899
Query: 909 CCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQA 968
CC DL+++LT S++L++L+L N L GV++ CE L+ C LQ LGL + F+ ET++
Sbjct: 900 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 959
Query: 969 LLTAEEERNPNLTI 982
L +E P LT+
Sbjct: 960 ALETLQEEKPELTV 973
Score = 54.3 bits (129), Expect = 6e-07
Identities = 32/85 (37%), Positives = 49/85 (57%), Gaps = 3/85 (3%)
Query: 881 VQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVV 940
VQ + + +H C GL LTS+ C+ L SVL+ S++L +L+L+ N+L G+ V
Sbjct: 704 VQCVLPSSSHAACSH---GLVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRV 760
Query: 941 LCEALRHPECALQVLGLRKTDFDEE 965
LCE L+HP C ++ L L + E
Sbjct: 761 LCETLQHPGCNIRRLWLGRCGLSHE 785
Score = 40.0 bits (92), Expect = 0.011
Identities = 20/65 (30%), Positives = 38/65 (58%), Gaps = 1/65 (1%)
Query: 626 CWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSVL 685
CW + ++LT+S LR+L + ++ L + + +C L+ SC LQ LG++ + F+ ++
Sbjct: 901 CWD-LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 959
Query: 686 LFEVL 690
E L
Sbjct: 960 ALETL 964
>gi|188536002 NLR family, pyrin domain containing 3 isoform d [Homo
sapiens]
Length = 979
Score = 451 bits (1159), Expect = e-126
Identities = 304/945 (32%), Positives = 470/945 (49%), Gaps = 116/945 (12%)
Query: 14 YLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWNITL 73
YLE+L+ + +KFK HL+ Q +P + +KA +LA L+I E++AW + +
Sbjct: 13 YLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAV 72
Query: 74 RIFQKMDRKDLCMKVMRE------------------------------------------ 91
IF ++R+DL K R+
Sbjct: 73 WIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKM 132
Query: 92 RTGYTKTYQAHAKQKF-------SRLWSSKSV----TEIHLYFEEEVKQEE--------- 131
+ Y K Y+ + + +F +RL S S+ T + L E +QE
Sbjct: 133 KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
Query: 132 ---CDH------LDRLFAPKEAGKQP-RTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDR 181
C+ ++ LF P + +P TV+ QG GIGKT L K+M+ W+ +++DR
Sbjct: 193 TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
Query: 182 FLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGLN 241
F Y FY CRE+ + SL DLI PDP PI +IV +P R+LF++D F+ELQG +
Sbjct: 253 FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
Query: 242 EPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRG 301
E LC D + +LLSSL+RKK+LPEASLLI +PV ++L+ + + G
Sbjct: 313 EHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILG 372
Query: 302 FNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDL 361
F+E+ R YF +F D +A AF+L++E+E LF++C IPL+CWI+CT LKQ+M+ GK L
Sbjct: 373 FSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSL 432
Query: 362 ALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLRR 421
A T ++TT+VY F+ +L P G H L LCSLAA+G+W F E DLR
Sbjct: 433 AQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAH-LWGLCSLAADGIWNQKILFEESDLRN 491
Query: 422 NGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAALFYLLK-----------SHL 470
+G+ AD+ A L + K + E Y F+H+ QEF AA++YLL+ S L
Sbjct: 492 HGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRL 551
Query: 471 DHPHPAVRCVQELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKLDAFFGFQLSQEIKQQ 530
P V +L+ N+ K + + IF+ FL GL+N++ L+ ++SQ+I+ +
Sbjct: 552 KLPSRDV----TVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLE 607
Query: 531 IHQCLKSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSA 590
+ + ++ + Q Q L +FYCL+EMQ+ FV++A++ + ++ +D +VS+
Sbjct: 608 LLKWIEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSS 667
Query: 591 YCLKYCSSLRKLCFSVQNVFKKEDE--------------------HSSTS------DYSL 624
+C++ C + L + KE+E H++ S S
Sbjct: 668 FCIENCHRVESLSLGFLHNMPKEEEEEEKEGRHLDMVQCVLPSSSHAACSHGLGRCGLSH 727
Query: 625 ICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSV 684
C I VL+++ L EL + D+ L + C L+H C L+KL + + +
Sbjct: 728 ECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACC 787
Query: 685 L-LFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVL 743
L VL L L L + LC+ P N+++L LVN L+ + C L
Sbjct: 788 QDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSAL 847
Query: 744 AGLLTNNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEM 802
+ +L+ N+ LT+L + N L D G+ LLCE L PD L L L C+L+ CC +S +
Sbjct: 848 SSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTL 907
Query: 803 LLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCF 847
L ++S+R L L N L D G+ CE LK C L +L L + +
Sbjct: 908 LTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMY 952
Score = 180 bits (457), Expect = 5e-45
Identities = 102/254 (40%), Positives = 150/254 (59%), Gaps = 1/254 (0%)
Query: 730 LVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAF 788
L C LS C ++ +L++N+KL L++S N L D G+ LLC L L L L
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVS 779
Query: 789 CHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFI 848
C L+ CC+ ++ +L + S+ L + N L D G+ LCE K+P C L L LV +
Sbjct: 780 CCLTSACCQDLASVLSTSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGL 839
Query: 849 TAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTST 908
T+ C L+S L +NQNL L + N +GD G++LLC L H DC+L++L L+ C LTS
Sbjct: 840 TSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSH 899
Query: 909 CCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQA 968
CC DL+++LT S++L++L+L N L GV++ CE L+ C LQ LGL + F+ ET++
Sbjct: 900 CCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 959
Query: 969 LLTAEEERNPNLTI 982
L +E P LT+
Sbjct: 960 ALETLQEEKPELTV 973
Score = 50.1 bits (118), Expect = 1e-05
Identities = 28/77 (36%), Positives = 44/77 (57%), Gaps = 3/77 (3%)
Query: 881 VQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVV 940
VQ + + +H C GL CGL+ CC D++ VL+ ++ L +L+L+ N L G+ +
Sbjct: 704 VQCVLPSSSHAACSH---GLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRL 760
Query: 941 LCEALRHPECALQVLGL 957
LC L+H C L+ L L
Sbjct: 761 LCVGLKHLLCNLKKLWL 777
Score = 40.0 bits (92), Expect = 0.011
Identities = 20/65 (30%), Positives = 38/65 (58%), Gaps = 1/65 (1%)
Query: 626 CWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSVL 685
CW + ++LT+S LR+L + ++ L + + +C L+ SC LQ LG++ + F+ ++
Sbjct: 901 CWD-LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 959
Query: 686 LFEVL 690
E L
Sbjct: 960 ALETL 964
>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
2 [Homo sapiens]
Length = 980
Score = 446 bits (1146), Expect = e-125
Identities = 319/1016 (31%), Positives = 513/1016 (50%), Gaps = 92/1016 (9%)
Query: 8 DFGLMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQ 67
++ L LE+L ++E + FK L L+ L++ PW+EV++A ++LA +L+ E
Sbjct: 7 EWTLQTLLEQLNEDELKSFKSLLWAFPLEDVLQKTPWSEVEEADGKKLAEILVNTSSENW 66
Query: 68 AWNITLRIFQKMDRKDLCMKVMRE-------------RTGYTKTYQAHAKQKFSRLWSSK 114
N T+ I ++M+ +LC E G + AK W +
Sbjct: 67 IRNATVNILEEMNLTELCKMAKAEMMEDGQVQEIDNPELGDAEEDSELAKPGEKEGWRN- 125
Query: 115 SVTEIHLYFEEEVKQEECDHL-------DRLFAPKEAGKQPR-----TVIIQGPQGIGKT 162
S+ + L ++ Q + D+ ++ F P + PR TV++ GP G+GKT
Sbjct: 126 SMEKQSLVWKNTFWQGDIDNFHDDVTLRNQRFIPFLNPRTPRKLTPYTVVLHGPAGVGKT 185
Query: 163 TLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQ 222
TL K M+ W+D + Y FY C+EL + P S A+LIS++WP+ I I++Q
Sbjct: 186 TLAKKCMLDWTDCNL-SPTLRYAFYLSCKELSRMGPCSFAELISKDWPELQDDIPSILAQ 244
Query: 223 PERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPV 282
+R+LFV+D +EL+ D+CGD +K+PV VLL SLL++KMLP A+LL+ +P
Sbjct: 245 AQRILFVVDGLDELKVPPGALIQDICGDWEKKKPVPVLLGSLLKRKMLPRAALLVTTRP- 303
Query: 283 CPKELRDQVTISE--IY-QPRGFNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQ 339
+ LRD +++ IY + GF E DR YF F D +AM AF L+R + LF +
Sbjct: 304 --RALRDLQLLAQQPIYVRVEGFLEEDRRAYFLRHFGDEDQAMRAFELMRSNAALFQLGS 361
Query: 340 IPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKAL 399
P +CWI+CT+LK +M+KG+D TC + T ++ F+ + F P+GA Q + L+ L
Sbjct: 362 APAVCWIVCTTLKLQMEKGEDPVPTCLTRTGLFLRFLCSRF-PQGA-----QLRGALRTL 415
Query: 400 CSLAAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFC 459
LAA+G+W F +DL R GV ++D+ L IL + + Y F+H+ Q+F
Sbjct: 416 SLLAAQGLWAQMSVFHREDLERLGVQESDLRLFLDGDILRQDRVSKGCYSFIHLSFQQFL 475
Query: 460 AALFYLLKSHLDHPHPA----VRCVQELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKL 515
ALFY L+ + VQ+LL E+ + I +G FL GL N+K ++L
Sbjct: 476 TALFYALEKEEGEDRDGHAWDIGDVQKLLSGE-ERLKNPDLIQVGHFLFGLANEKRAKEL 534
Query: 516 DAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQE 575
+A FG ++S +IKQ++ QC L P D + CL+E Q+ K V +E
Sbjct: 535 EATFGCRMSPDIKQELLQCKAHL-HANKPLSVTDLKEVLGCLYESQEEELAKVVVAPFKE 593
Query: 576 ANFHIIDNVDLVVSAYCLKYCSSLRKLCFSV-QNVFKKEDEHSSTSDYSLICWHHICSVL 634
+ H+ + +++ ++ LK+C L+KL V + VF + + D+ L C+ L
Sbjct: 594 ISIHLTNTSEVMHCSFSLKHCQDLQKLSLQVAKGVFLE-----NYMDFELDIEFERCTYL 648
Query: 635 TTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQP 694
T R+ S + +C+ FS S
Sbjct: 649 TIPNWARQ-----DLRSLRLWTDFCSL-----------------FSSNS----------- 675
Query: 695 DLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLT 754
+LK+L + LS +R LCD + +++++ + N + + K LT
Sbjct: 676 NLKFLEVKQSFLSDSSVRILCDHVTRSTCHLQKVEIKNVTPDTAYRDFCLAFI-GKKTLT 734
Query: 755 YLNVS--CNQLDTGVPLLCEALCSPDTVLVYLMLA-FCHLSEQCCEYISEMLLRNKSVRY 811
+L ++ T + +LC+ L + L YL L C EQ E+ +L N+S+++
Sbjct: 735 HLTLAGHIEWERTMMLMLCDLLRNHKCNLQYLRLGGHCATPEQWAEFFY-VLKANQSLKH 793
Query: 812 LDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQI 871
L LSANVL DEG L + + P L L L C +T A C+DLA+ L+ ++ L L +
Sbjct: 794 LRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCL 853
Query: 872 GCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLN 931
N IGD GV+ LC L++ DC+L+ L L++C +T C+ L+ L + +L L+L++N
Sbjct: 854 AKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSIN 913
Query: 932 TLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITDDCD 987
+ G+ +LC+AL +P C L+ L L+ + + E + LL +E+NP LTI DC+
Sbjct: 914 QIAR-GLWILCQALENPNCNLKHLRLKTYETNLEIKKLLEEVKEKNPKLTI--DCN 966
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 433 bits (1114), Expect = e-121
Identities = 293/916 (31%), Positives = 456/916 (49%), Gaps = 115/916 (12%)
Query: 14 YLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWNITL 73
YLE+L+ + +KFK HL+ Q +P + +KA +LA L+I E++AW + +
Sbjct: 13 YLEDLEDVDLKKFKMHLEDYPPQKGCIPLPRGQTEKADHVDLATLMIDFNGEEKAWAMAV 72
Query: 74 RIFQKMDRKDLCMKVMRE------------------------------------------ 91
IF ++R+DL K R+
Sbjct: 73 WIFAAINRRDLYEKAKRDEPKWGSDNARVSNPTVICQEDSIEEEWMGLLEYLSRISICKM 132
Query: 92 RTGYTKTYQAHAKQKF-------SRLWSSKSV----TEIHLYFEEEVKQEE--------- 131
+ Y K Y+ + + +F +RL S S+ T + L E +QE
Sbjct: 133 KKDYRKKYRKYVRSRFQCIEDRNARLGESVSLNKRYTRLRLIKEHRSQQEREQELLAIGK 192
Query: 132 ---CDH------LDRLFAPKEAGKQP-RTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDR 181
C+ ++ LF P + +P TV+ QG GIGKT L K+M+ W+ +++DR
Sbjct: 193 TKTCESPVSPIKMELLFDPDDEHSEPVHTVVFQGAAGIGKTILARKMMLDWASGTLYQDR 252
Query: 182 FLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGLN 241
F Y FY CRE+ + SL DLI PDP PI +IV +P R+LF++D F+ELQG +
Sbjct: 253 FDYLFYIHCREVSLVTQRSLGDLIMSCCPDPNPPIHKIVRKPSRILFLMDGFDELQGAFD 312
Query: 242 EPDSDLCGDLMEKRPVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRG 301
E LC D + +LLSSL+RKK+LPEASLLI +PV ++L+ + + G
Sbjct: 313 EHIGPLCTDWQKAERGDILLSSLIRKKLLPEASLLITTRPVALEKLQHLLDHPRHVEILG 372
Query: 302 FNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDL 361
F+E+ R YF +F D +A AF+L++E+E LF++C IPL+CWI+CT LKQ+M+ GK L
Sbjct: 373 FSEAKRKEYFFKYFSDEAQARAAFSLIQENEVLFTMCFIPLVCWIVCTGLKQQMESGKSL 432
Query: 362 ALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLRR 421
A T ++TT+VY F+ +L P G H L LCSLAA+G+W F E DLR
Sbjct: 433 AQTSKTTTAVYVFFLSSLLQPRGGSQEHGLCAH-LWGLCSLAADGIWNQKILFEESDLRN 491
Query: 422 NGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDH----PHPAV 477
+G+ AD+ A L + K + E Y F+H+ QEF AA++YLL+ + P +
Sbjct: 492 HGLQKADVSAFLRMNLFQKEVDCEKFYSFIHMTFQEFFAAMYYLLEEEKEGRTNVPGSRL 551
Query: 478 RCVQE---LLVANFEKARRAHWIFLGCFLTGLLNKKEQEKLDAFFGFQLSQEIKQQIHQC 534
+ +L+ N+ K + + IF+ FL GL+N++ L+ ++SQ+I+ ++ +
Sbjct: 552 KLPSRDVTVLLENYGKFEKGYLIFVVRFLFGLVNQERTSYLEKKLSCKISQQIRLELLKW 611
Query: 535 LKSLGERGNPQGQVDSLAIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLK 594
++ + Q Q L +FYCL+EMQ+ FV++A++ + ++ +D +VS++C++
Sbjct: 612 IEVKAKAKKLQIQPSQLELFYCLYEMQEEDFVQRAMDYFPKIEINLSTRMDHMVSSFCIE 671
Query: 595 YCSSLRKLCFSVQNVFKKEDEHSSTSDYSLICWHHICSVLTTSGHLRELQVQDSTLSEST 654
C + L + KE+E R L + L S+
Sbjct: 672 NCHRVESLSLGFLHNMPKEEEEEEKEG-------------------RHLDMVQCVLPSSS 712
Query: 655 FVTWCNQLRHPSCR--LQKLGINNVSFSGQSVLLFEVLFYQPDLKYLSFTLTKLSRDDIR 712
H +C L + G+++ S+ VL L L + L IR
Sbjct: 713 ---------HAACSHGLGRCGLSHECCFDISL----VLSSNQKLVELDLSDNALGDFGIR 759
Query: 713 SLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQL-DTGVPLLC 771
LC L + N+K+L LVN L+ + C L+ +L+ N+ LT+L + N L D G+ LLC
Sbjct: 760 LLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLC 819
Query: 772 EALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEAL 831
E L PD L L L C+L+ CC +S +L ++S+R L L N L D G+ CE L
Sbjct: 820 EGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVL 879
Query: 832 KHPDCCLDSLCLVKCF 847
K C L +L L + +
Sbjct: 880 KQQSCLLQNLGLSEMY 895
Score = 164 bits (416), Expect = 3e-40
Identities = 87/197 (44%), Positives = 122/197 (61%)
Query: 786 LAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVK 845
L C LS +CC IS +L N+ + LDLS N L D G++ LC LKH C L L LV
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVN 779
Query: 846 CFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGL 905
+T+ C L+S L +NQNL L + N +GD G++LLC L H DC+L++L L+ C L
Sbjct: 780 SGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNL 839
Query: 906 TSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEE 965
TS CC DL+++LT S++L++L+L N L GV++ CE L+ C LQ LGL + F+ E
Sbjct: 840 TSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYE 899
Query: 966 TQALLTAEEERNPNLTI 982
T++ L +E P LT+
Sbjct: 900 TKSALETLQEEKPELTV 916
Score = 118 bits (296), Expect = 2e-26
Identities = 70/174 (40%), Positives = 101/174 (58%), Gaps = 1/174 (0%)
Query: 730 LVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAF 788
L C LS C ++ +L++N+KL L++S N L D G+ LLC L L L L
Sbjct: 720 LGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVN 779
Query: 789 CHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFI 848
L+ CC +S +L N+++ +L L N L D+G+K LCE L HPDC L L L C +
Sbjct: 780 SGLTSVCCSALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNL 839
Query: 849 TAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEE 902
T+ C DL++ L S+Q+L+ L +G N++GD+GV + C L C L+ LGL E
Sbjct: 840 TSHCCWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSE 893
Score = 53.9 bits (128), Expect = 7e-07
Identities = 33/101 (32%), Positives = 53/101 (52%), Gaps = 3/101 (2%)
Query: 881 VQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVV 940
VQ + + +H C GL CGL+ CC D++ VL+ ++ L +L+L+ N L G+ +
Sbjct: 704 VQCVLPSSSHAACSH---GLGRCGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRL 760
Query: 941 LCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLT 981
LC L+H C L+ L L + + L++ N NLT
Sbjct: 761 LCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLT 801
Score = 40.0 bits (92), Expect = 0.011
Identities = 20/65 (30%), Positives = 38/65 (58%), Gaps = 1/65 (1%)
Query: 626 CWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSVL 685
CW + ++LT+S LR+L + ++ L + + +C L+ SC LQ LG++ + F+ ++
Sbjct: 844 CWD-LSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKS 902
Query: 686 LFEVL 690
E L
Sbjct: 903 ALETL 907
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 320 bits (819), Expect = 5e-87
Identities = 221/677 (32%), Positives = 354/677 (52%), Gaps = 47/677 (6%)
Query: 138 LFAPKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELP 197
LF P ++PR VI+QG GIGK+TL ++ AW +++ DRF + FYF CREL +
Sbjct: 317 LFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSK 376
Query: 198 PTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPV 257
SLA+LI ++ API +I+S+PERLLF++D +E L EP S+LC + +P
Sbjct: 377 VVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPA 436
Query: 258 QVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRGFNESDRLVYFCCFFKD 317
LL SLL K +LPEAS LI + + L + + + GF+ES R YF +F D
Sbjct: 437 DALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTD 496
Query: 318 PKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVF 377
++A+ AF LV+ +++L+++C +P + W+ CT L Q+M++ + L LT ++TT++ ++
Sbjct: 497 ERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLA 556
Query: 378 NLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKI 437
+ GP QL+ LCSLAAEG+W F DDLR++G+ A I L I
Sbjct: 557 QALQAQPL-GP------QLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGI 609
Query: 438 LLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDHPHPAVRCVQELLVANFEKARRAHWI 497
L ++ SY F+H+C QEF AA+ Y+L+ + C+ +L EK A+ I
Sbjct: 610 LQEH-PIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHS-NCIIDL-----EKTLEAYGI 662
Query: 498 --FLGC----FLTGLLNKKEQEKLDAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQVDSL 551
G FL GLL+ + + +++ F +LSQ + + Q + SL P SL
Sbjct: 663 HGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWVPSLQLLLQPH----SL 716
Query: 552 AIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLKYCSSLRKLCFSVQNVFK 611
+CL+E ++ F+ Q + +E + +++L+V +C+K+ ++KL
Sbjct: 717 ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKL------QLI 770
Query: 612 KEDEHSSTSDYSLIC-----------WHHICSVLTTSGHLRELQVQDSTLSESTFVTWCN 660
+ +H ST +++ W + SVL + +L+EL + ++LS S + C
Sbjct: 771 EGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCK 830
Query: 661 QLRHPSCRLQKLGINNVSFSGQSV--LLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDAL 718
LR P C L+ L + + + L F + Q L L + L+ + LC L
Sbjct: 831 TLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ-TLTELDLSFNVLTDAGAKHLCQRL 889
Query: 719 NYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQL-DTGVPLLCEALCSP 777
P+ ++ L LV+C L+ C+ LA +L+ + L L++ N L D GV LLCE L P
Sbjct: 890 RQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHP 949
Query: 778 DTVLVYLMLAFCHLSEQ 794
L+ L L LS++
Sbjct: 950 ACKLIRLGLDQTTLSDE 966
Score = 153 bits (386), Expect = 9e-37
Identities = 80/186 (43%), Positives = 113/186 (60%)
Query: 797 EYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDL 856
+ + +L ++++ LDLS N L +K+LC+ L+ P C L++L L C +TA C+DL
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 857 ASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASV 916
A L +NQ L L + N + D G + LC+ L C+L+ L L CGLTS CC+DLASV
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 917 LTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEER 976
L+ S +L++L+L N LD GV +LCE LRHP C L LGL +T +E + L A E+
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQE 977
Query: 977 NPNLTI 982
P L I
Sbjct: 978 KPQLLI 983
Score = 115 bits (287), Expect = 3e-25
Identities = 68/177 (38%), Positives = 104/177 (58%), Gaps = 1/177 (0%)
Query: 741 EVLAGLLTNNKKLTYLNVSCNQLD-TGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYI 799
++L +L + L L++S N L + V LC+ L P +L L LA C L+ + C+ +
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 800 SEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASA 859
+ L N+++ LDLS NVL D G K LC+ L+ P C L L LV C +T+ C+DLAS
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 860 LISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASV 916
L ++ +LK L + N + DVGV+LLC L H C+L LGL++ L+ ++L ++
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRAL 974
Score = 79.3 bits (194), Expect = 2e-14
Identities = 46/110 (41%), Positives = 60/110 (54%)
Query: 848 ITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTS 907
+T A + L S L +NLK L + N + V+ LC+ L C LE L L CGLT+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 908 TCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGL 957
CKDLA L ++TL +L+L+ N L G LC+ LR P C LQ L L
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQL 901
Score = 47.4 bits (111), Expect = 7e-05
Identities = 27/89 (30%), Positives = 48/89 (53%), Gaps = 1/89 (1%)
Query: 11 LMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWN 70
L YLE LKKEE ++F+ L + +K S E+A+ L+ Y EQ+AW+
Sbjct: 9 LACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAWD 68
Query: 71 ITLRIFQKMDRKDLCMKVMRERTGYTKTY 99
+ L +++M + LC + +E G++ ++
Sbjct: 69 LALHTWEQMGLRSLCAQA-QEGAGHSPSF 96
Score = 42.7 bits (99), Expect = 0.002
Identities = 26/72 (36%), Positives = 36/72 (50%)
Query: 913 LASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTA 972
L SVL ++ L++L+L+ N+L H+ V LC+ LR P C L+ L L E L
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 973 EEERNPNLTITD 984
N LT D
Sbjct: 860 GLRANQTLTELD 871
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 320 bits (819), Expect = 5e-87
Identities = 221/677 (32%), Positives = 354/677 (52%), Gaps = 47/677 (6%)
Query: 138 LFAPKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELP 197
LF P ++PR VI+QG GIGK+TL ++ AW +++ DRF + FYF CREL +
Sbjct: 317 LFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSK 376
Query: 198 PTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPV 257
SLA+LI ++ API +I+S+PERLLF++D +E L EP S+LC + +P
Sbjct: 377 VVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPA 436
Query: 258 QVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRGFNESDRLVYFCCFFKD 317
LL SLL K +LPEAS LI + + L + + + GF+ES R YF +F D
Sbjct: 437 DALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTD 496
Query: 318 PKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVF 377
++A+ AF LV+ +++L+++C +P + W+ CT L Q+M++ + L LT ++TT++ ++
Sbjct: 497 ERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLA 556
Query: 378 NLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKI 437
+ GP QL+ LCSLAAEG+W F DDLR++G+ A I L I
Sbjct: 557 QALQAQPL-GP------QLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGI 609
Query: 438 LLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDHPHPAVRCVQELLVANFEKARRAHWI 497
L ++ SY F+H+C QEF AA+ Y+L+ + C+ +L EK A+ I
Sbjct: 610 LQEH-PIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHS-NCIIDL-----EKTLEAYGI 662
Query: 498 --FLGC----FLTGLLNKKEQEKLDAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQVDSL 551
G FL GLL+ + + +++ F +LSQ + + Q + SL P SL
Sbjct: 663 HGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWVPSLQLLLQPH----SL 716
Query: 552 AIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLKYCSSLRKLCFSVQNVFK 611
+CL+E ++ F+ Q + +E + +++L+V +C+K+ ++KL
Sbjct: 717 ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKL------QLI 770
Query: 612 KEDEHSSTSDYSLIC-----------WHHICSVLTTSGHLRELQVQDSTLSESTFVTWCN 660
+ +H ST +++ W + SVL + +L+EL + ++LS S + C
Sbjct: 771 EGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCK 830
Query: 661 QLRHPSCRLQKLGINNVSFSGQSV--LLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDAL 718
LR P C L+ L + + + L F + Q L L + L+ + LC L
Sbjct: 831 TLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ-TLTELDLSFNVLTDAGAKHLCQRL 889
Query: 719 NYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQL-DTGVPLLCEALCSP 777
P+ ++ L LV+C L+ C+ LA +L+ + L L++ N L D GV LLCE L P
Sbjct: 890 RQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHP 949
Query: 778 DTVLVYLMLAFCHLSEQ 794
L+ L L LS++
Sbjct: 950 ACKLIRLGLDQTTLSDE 966
Score = 153 bits (386), Expect = 9e-37
Identities = 80/186 (43%), Positives = 113/186 (60%)
Query: 797 EYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDL 856
+ + +L ++++ LDLS N L +K+LC+ L+ P C L++L L C +TA C+DL
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 857 ASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASV 916
A L +NQ L L + N + D G + LC+ L C+L+ L L CGLTS CC+DLASV
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 917 LTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEER 976
L+ S +L++L+L N LD GV +LCE LRHP C L LGL +T +E + L A E+
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQE 977
Query: 977 NPNLTI 982
P L I
Sbjct: 978 KPQLLI 983
Score = 115 bits (287), Expect = 3e-25
Identities = 68/177 (38%), Positives = 104/177 (58%), Gaps = 1/177 (0%)
Query: 741 EVLAGLLTNNKKLTYLNVSCNQLD-TGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYI 799
++L +L + L L++S N L + V LC+ L P +L L LA C L+ + C+ +
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 800 SEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASA 859
+ L N+++ LDLS NVL D G K LC+ L+ P C L L LV C +T+ C+DLAS
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 860 LISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASV 916
L ++ +LK L + N + DVGV+LLC L H C+L LGL++ L+ ++L ++
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRAL 974
Score = 79.3 bits (194), Expect = 2e-14
Identities = 46/110 (41%), Positives = 60/110 (54%)
Query: 848 ITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTS 907
+T A + L S L +NLK L + N + V+ LC+ L C LE L L CGLT+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 908 TCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGL 957
CKDLA L ++TL +L+L+ N L G LC+ LR P C LQ L L
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQL 901
Score = 47.4 bits (111), Expect = 7e-05
Identities = 27/89 (30%), Positives = 48/89 (53%), Gaps = 1/89 (1%)
Query: 11 LMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWN 70
L YLE LKKEE ++F+ L + +K S E+A+ L+ Y EQ+AW+
Sbjct: 9 LACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAWD 68
Query: 71 ITLRIFQKMDRKDLCMKVMRERTGYTKTY 99
+ L +++M + LC + +E G++ ++
Sbjct: 69 LALHTWEQMGLRSLCAQA-QEGAGHSPSF 96
Score = 42.7 bits (99), Expect = 0.002
Identities = 26/72 (36%), Positives = 36/72 (50%)
Query: 913 LASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTA 972
L SVL ++ L++L+L+ N+L H+ V LC+ LR P C L+ L L E L
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 973 EEERNPNLTITD 984
N LT D
Sbjct: 860 GLRANQTLTELD 871
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 320 bits (819), Expect = 5e-87
Identities = 221/677 (32%), Positives = 354/677 (52%), Gaps = 47/677 (6%)
Query: 138 LFAPKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELP 197
LF P ++PR VI+QG GIGK+TL ++ AW +++ DRF + FYF CREL +
Sbjct: 317 LFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSK 376
Query: 198 PTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPV 257
SLA+LI ++ API +I+S+PERLLF++D +E L EP S+LC + +P
Sbjct: 377 VVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPA 436
Query: 258 QVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRGFNESDRLVYFCCFFKD 317
LL SLL K +LPEAS LI + + L + + + GF+ES R YF +F D
Sbjct: 437 DALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTD 496
Query: 318 PKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVF 377
++A+ AF LV+ +++L+++C +P + W+ CT L Q+M++ + L LT ++TT++ ++
Sbjct: 497 ERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLA 556
Query: 378 NLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKI 437
+ GP QL+ LCSLAAEG+W F DDLR++G+ A I L I
Sbjct: 557 QALQAQPL-GP------QLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGI 609
Query: 438 LLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDHPHPAVRCVQELLVANFEKARRAHWI 497
L ++ SY F+H+C QEF AA+ Y+L+ + C+ +L EK A+ I
Sbjct: 610 LQEH-PIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHS-NCIIDL-----EKTLEAYGI 662
Query: 498 --FLGC----FLTGLLNKKEQEKLDAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQVDSL 551
G FL GLL+ + + +++ F +LSQ + + Q + SL P SL
Sbjct: 663 HGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWVPSLQLLLQPH----SL 716
Query: 552 AIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLKYCSSLRKLCFSVQNVFK 611
+CL+E ++ F+ Q + +E + +++L+V +C+K+ ++KL
Sbjct: 717 ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKL------QLI 770
Query: 612 KEDEHSSTSDYSLIC-----------WHHICSVLTTSGHLRELQVQDSTLSESTFVTWCN 660
+ +H ST +++ W + SVL + +L+EL + ++LS S + C
Sbjct: 771 EGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCK 830
Query: 661 QLRHPSCRLQKLGINNVSFSGQSV--LLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDAL 718
LR P C L+ L + + + L F + Q L L + L+ + LC L
Sbjct: 831 TLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ-TLTELDLSFNVLTDAGAKHLCQRL 889
Query: 719 NYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQL-DTGVPLLCEALCSP 777
P+ ++ L LV+C L+ C+ LA +L+ + L L++ N L D GV LLCE L P
Sbjct: 890 RQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHP 949
Query: 778 DTVLVYLMLAFCHLSEQ 794
L+ L L LS++
Sbjct: 950 ACKLIRLGLDQTTLSDE 966
Score = 153 bits (386), Expect = 9e-37
Identities = 80/186 (43%), Positives = 113/186 (60%)
Query: 797 EYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDL 856
+ + +L ++++ LDLS N L +K+LC+ L+ P C L++L L C +TA C+DL
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 857 ASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASV 916
A L +NQ L L + N + D G + LC+ L C+L+ L L CGLTS CC+DLASV
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 917 LTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEER 976
L+ S +L++L+L N LD GV +LCE LRHP C L LGL +T +E + L A E+
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRALEQE 977
Query: 977 NPNLTI 982
P L I
Sbjct: 978 KPQLLI 983
Score = 115 bits (287), Expect = 3e-25
Identities = 68/177 (38%), Positives = 104/177 (58%), Gaps = 1/177 (0%)
Query: 741 EVLAGLLTNNKKLTYLNVSCNQLD-TGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYI 799
++L +L + L L++S N L + V LC+ L P +L L LA C L+ + C+ +
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 800 SEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASA 859
+ L N+++ LDLS NVL D G K LC+ L+ P C L L LV C +T+ C+DLAS
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 860 LISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASV 916
L ++ +LK L + N + DVGV+LLC L H C+L LGL++ L+ ++L ++
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQTTLSDEMRQELRAL 974
Score = 79.3 bits (194), Expect = 2e-14
Identities = 46/110 (41%), Positives = 60/110 (54%)
Query: 848 ITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTS 907
+T A + L S L +NLK L + N + V+ LC+ L C LE L L CGLT+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 908 TCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGL 957
CKDLA L ++TL +L+L+ N L G LC+ LR P C LQ L L
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQL 901
Score = 47.4 bits (111), Expect = 7e-05
Identities = 27/89 (30%), Positives = 48/89 (53%), Gaps = 1/89 (1%)
Query: 11 LMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWN 70
L YLE LKKEE ++F+ L + +K S E+A+ L+ Y EQ+AW+
Sbjct: 9 LACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAWD 68
Query: 71 ITLRIFQKMDRKDLCMKVMRERTGYTKTY 99
+ L +++M + LC + +E G++ ++
Sbjct: 69 LALHTWEQMGLRSLCAQA-QEGAGHSPSF 96
Score = 42.7 bits (99), Expect = 0.002
Identities = 26/72 (36%), Positives = 36/72 (50%)
Query: 913 LASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTA 972
L SVL ++ L++L+L+ N+L H+ V LC+ LR P C L+ L L E L
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 973 EEERNPNLTITD 984
N LT D
Sbjct: 860 GLRANQTLTELD 871
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 318 bits (814), Expect = 2e-86
Identities = 218/667 (32%), Positives = 349/667 (52%), Gaps = 47/667 (7%)
Query: 138 LFAPKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELP 197
LF P ++PR VI+QG GIGK+TL ++ AW +++ DRF + FYF CREL +
Sbjct: 317 LFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSK 376
Query: 198 PTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPV 257
SLA+LI ++ API +I+S+PERLLF++D +E L EP S+LC + +P
Sbjct: 377 VVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPA 436
Query: 258 QVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRGFNESDRLVYFCCFFKD 317
LL SLL K +LPEAS LI + + L + + + GF+ES R YF +F D
Sbjct: 437 DALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTD 496
Query: 318 PKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVF 377
++A+ AF LV+ +++L+++C +P + W+ CT L Q+M++ + L LT ++TT++ ++
Sbjct: 497 ERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLA 556
Query: 378 NLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKI 437
+ GP QL+ LCSLAAEG+W F DDLR++G+ A I L I
Sbjct: 557 QALQAQPL-GP------QLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGI 609
Query: 438 LLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDHPHPAVRCVQELLVANFEKARRAHWI 497
L ++ SY F+H+C QEF AA+ Y+L+ + C+ +L EK A+ I
Sbjct: 610 LQEH-PIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHS-NCIIDL-----EKTLEAYGI 662
Query: 498 --FLGC----FLTGLLNKKEQEKLDAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQVDSL 551
G FL GLL+ + + +++ F +LSQ + + Q + SL P SL
Sbjct: 663 HGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWVPSLQLLLQPH----SL 716
Query: 552 AIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLKYCSSLRKLCFSVQNVFK 611
+CL+E ++ F+ Q + +E + +++L+V +C+K+ ++KL
Sbjct: 717 ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKL------QLI 770
Query: 612 KEDEHSSTSDYSLIC-----------WHHICSVLTTSGHLRELQVQDSTLSESTFVTWCN 660
+ +H ST +++ W + SVL + +L+EL + ++LS S + C
Sbjct: 771 EGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCK 830
Query: 661 QLRHPSCRLQKLGINNVSFSGQSV--LLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDAL 718
LR P C L+ L + + + L F + Q L L + L+ + LC L
Sbjct: 831 TLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ-TLTELDLSFNVLTDAGAKHLCQRL 889
Query: 719 NYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQL-DTGVPLLCEALCSP 777
P+ ++ L LV+C L+ C+ LA +L+ + L L++ N L D GV LLCE L P
Sbjct: 890 RQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHP 949
Query: 778 DTVLVYL 784
L+ L
Sbjct: 950 ACKLIRL 956
Score = 140 bits (353), Expect = 6e-33
Identities = 76/177 (42%), Positives = 106/177 (59%), Gaps = 2/177 (1%)
Query: 797 EYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDL 856
+ + +L ++++ LDLS N L +K+LC+ L+ P C L++L L C +TA C+DL
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 857 ASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASV 916
A L +NQ L L + N + D G + LC+ L C+L+ L L CGLTS CC+DLASV
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 917 LTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAE 973
L+ S +L++L+L N LD GV +LCE LRHP C L LG K T+ L T E
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG--KPSVMTPTEGLDTGE 972
Score = 110 bits (274), Expect = 9e-24
Identities = 65/160 (40%), Positives = 94/160 (58%), Gaps = 1/160 (0%)
Query: 741 EVLAGLLTNNKKLTYLNVSCNQLD-TGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYI 799
++L +L + L L++S N L + V LC+ L P +L L LA C L+ + C+ +
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 800 SEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASA 859
+ L N+++ LDLS NVL D G K LC+ L+ P C L L LV C +T+ C+DLAS
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 860 LISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILG 899
L ++ +LK L + N + DVGV+LLC L H C+L LG
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
Score = 79.3 bits (194), Expect = 2e-14
Identities = 46/110 (41%), Positives = 60/110 (54%)
Query: 848 ITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTS 907
+T A + L S L +NLK L + N + V+ LC+ L C LE L L CGLT+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 908 TCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGL 957
CKDLA L ++TL +L+L+ N L G LC+ LR P C LQ L L
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQL 901
Score = 47.4 bits (111), Expect = 7e-05
Identities = 27/89 (30%), Positives = 48/89 (53%), Gaps = 1/89 (1%)
Query: 11 LMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWN 70
L YLE LKKEE ++F+ L + +K S E+A+ L+ Y EQ+AW+
Sbjct: 9 LACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAWD 68
Query: 71 ITLRIFQKMDRKDLCMKVMRERTGYTKTY 99
+ L +++M + LC + +E G++ ++
Sbjct: 69 LALHTWEQMGLRSLCAQA-QEGAGHSPSF 96
Score = 42.7 bits (99), Expect = 0.002
Identities = 26/72 (36%), Positives = 36/72 (50%)
Query: 913 LASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTA 972
L SVL ++ L++L+L+ N+L H+ V LC+ LR P C L+ L L E L
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 973 EEERNPNLTITD 984
N LT D
Sbjct: 860 GLRANQTLTELD 871
Score = 42.4 bits (98), Expect = 0.002
Identities = 40/146 (27%), Positives = 68/146 (46%), Gaps = 14/146 (9%)
Query: 532 HQCLKSLGER-GNPQGQVDSLAIFYCLF---EMQDPAFVKQAVNLLQEANFHIIDNVDLV 587
H +KSL + P+ +++L + C + +D AF +A L E + + +++
Sbjct: 822 HSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDL----SFNVL 877
Query: 588 VSAYCLKYCSSLRKLCFSVQNVFKKEDEHSSTSDYSLICWHHICSVLTTSGHLRELQVQD 647
A C LR+ +Q + + TSD C + SVL+ S L+EL +Q
Sbjct: 878 TDAGAKHLCQRLRQPSCKLQRL--QLVSCGLTSD----CCQDLASVLSASPSLKELDLQQ 931
Query: 648 STLSESTFVTWCNQLRHPSCRLQKLG 673
+ L + C LRHP+C+L +LG
Sbjct: 932 NNLDDVGVRLLCEGLRHPACKLIRLG 957
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 318 bits (814), Expect = 2e-86
Identities = 218/667 (32%), Positives = 349/667 (52%), Gaps = 47/667 (7%)
Query: 138 LFAPKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELP 197
LF P ++PR VI+QG GIGK+TL ++ AW +++ DRF + FYF CREL +
Sbjct: 317 LFGPGLDTQEPRIVILQGAAGIGKSTLARQVKEAWGRGQLYGDRFQHVFYFSCRELAQSK 376
Query: 198 PTSLADLISREWPDPAAPITEIVSQPERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPV 257
SLA+LI ++ API +I+S+PERLLF++D +E L EP S+LC + +P
Sbjct: 377 VVSLAELIGKDGTATPAPIRQILSRPERLLFILDGVDEPGWVLQEPSSELCLHWSQPQPA 436
Query: 258 QVLLSSLLRKKMLPEASLLIAIKPVCPKELRDQVTISEIYQPRGFNESDRLVYFCCFFKD 317
LL SLL K +LPEAS LI + + L + + + GF+ES R YF +F D
Sbjct: 437 DALLGSLLGKTILPEASFLITARTTALQNLIPSLEQARWVEVLGFSESSRKEYFYRYFTD 496
Query: 318 PKRAMEAFNLVRESEQLFSICQIPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVF 377
++A+ AF LV+ +++L+++C +P + W+ CT L Q+M++ + L LT ++TT++ ++
Sbjct: 497 ERQAIRAFRLVKSNKELWALCLVPWVSWLACTCLMQQMKRKEKLTLTSKTTTTLCLHYLA 556
Query: 378 NLFTPEGAEGPTPQTQHQLKALCSLAAEGMWTDTFEFCEDDLRRNGVVDADIPALLGTKI 437
+ GP QL+ LCSLAAEG+W F DDLR++G+ A I L I
Sbjct: 557 QALQAQPL-GP------QLRDLCSLAAEGIWQKKTLFSPDDLRKHGLDGAIISTFLKMGI 609
Query: 438 LLKYGERESSYVFLHVCIQEFCAALFYLLKSHLDHPHPAVRCVQELLVANFEKARRAHWI 497
L ++ SY F+H+C QEF AA+ Y+L+ + C+ +L EK A+ I
Sbjct: 610 LQEH-PIPLSYSFIHLCFQEFFAAMSYVLEDEKGRGKHS-NCIIDL-----EKTLEAYGI 662
Query: 498 --FLGC----FLTGLLNKKEQEKLDAFFGFQLSQEIKQQIHQCLKSLGERGNPQGQVDSL 551
G FL GLL+ + + +++ F +LSQ + + Q + SL P SL
Sbjct: 663 HGLFGASTTRFLLGLLSDEGEREMENIFHCRLSQ--GRNLMQWVPSLQLLLQPH----SL 716
Query: 552 AIFYCLFEMQDPAFVKQAVNLLQEANFHIIDNVDLVVSAYCLKYCSSLRKLCFSVQNVFK 611
+CL+E ++ F+ Q + +E + +++L+V +C+K+ ++KL
Sbjct: 717 ESLHCLYETRNKTFLTQVMAHFEEMGMCVETDMELLVCTFCIKFSRHVKKL------QLI 770
Query: 612 KEDEHSSTSDYSLIC-----------WHHICSVLTTSGHLRELQVQDSTLSESTFVTWCN 660
+ +H ST +++ W + SVL + +L+EL + ++LS S + C
Sbjct: 771 EGRQHRSTWSPTMVVLFRWVPVTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCK 830
Query: 661 QLRHPSCRLQKLGINNVSFSGQSV--LLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDAL 718
LR P C L+ L + + + L F + Q L L + L+ + LC L
Sbjct: 831 TLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQ-TLTELDLSFNVLTDAGAKHLCQRL 889
Query: 719 NYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQL-DTGVPLLCEALCSP 777
P+ ++ L LV+C L+ C+ LA +L+ + L L++ N L D GV LLCE L P
Sbjct: 890 RQPSCKLQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHP 949
Query: 778 DTVLVYL 784
L+ L
Sbjct: 950 ACKLIRL 956
Score = 140 bits (353), Expect = 6e-33
Identities = 76/177 (42%), Positives = 106/177 (59%), Gaps = 2/177 (1%)
Query: 797 EYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDL 856
+ + +L ++++ LDLS N L +K+LC+ L+ P C L++L L C +TA C+DL
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 857 ASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASV 916
A L +NQ L L + N + D G + LC+ L C+L+ L L CGLTS CC+DLASV
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 917 LTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAE 973
L+ S +L++L+L N LD GV +LCE LRHP C L LG K T+ L T E
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG--KPSVMTPTEGLDTGE 972
Score = 110 bits (274), Expect = 9e-24
Identities = 65/160 (40%), Positives = 94/160 (58%), Gaps = 1/160 (0%)
Query: 741 EVLAGLLTNNKKLTYLNVSCNQLD-TGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYI 799
++L +L + L L++S N L + V LC+ L P +L L LA C L+ + C+ +
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 800 SEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASA 859
+ L N+++ LDLS NVL D G K LC+ L+ P C L L LV C +T+ C+DLAS
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 860 LISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILG 899
L ++ +LK L + N + DVGV+LLC L H C+L LG
Sbjct: 918 LSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLG 957
Score = 79.3 bits (194), Expect = 2e-14
Identities = 46/110 (41%), Positives = 60/110 (54%)
Query: 848 ITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTS 907
+T A + L S L +NLK L + N + V+ LC+ L C LE L L CGLT+
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 908 TCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGL 957
CKDLA L ++TL +L+L+ N L G LC+ LR P C LQ L L
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQL 901
Score = 47.4 bits (111), Expect = 7e-05
Identities = 27/89 (30%), Positives = 48/89 (53%), Gaps = 1/89 (1%)
Query: 11 LMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWN 70
L YLE LKKEE ++F+ L + +K S E+A+ L+ Y EQ+AW+
Sbjct: 9 LACYLEFLKKEELKEFQLLLANKAHSRSSSGETPAQPEKTSGMEVASYLVAQYGEQRAWD 68
Query: 71 ITLRIFQKMDRKDLCMKVMRERTGYTKTY 99
+ L +++M + LC + +E G++ ++
Sbjct: 69 LALHTWEQMGLRSLCAQA-QEGAGHSPSF 96
Score = 42.7 bits (99), Expect = 0.002
Identities = 26/72 (36%), Positives = 36/72 (50%)
Query: 913 LASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTA 972
L SVL ++ L++L+L+ N+L H+ V LC+ LR P C L+ L L E L
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 973 EEERNPNLTITD 984
N LT D
Sbjct: 860 GLRANQTLTELD 871
Score = 42.4 bits (98), Expect = 0.002
Identities = 40/146 (27%), Positives = 68/146 (46%), Gaps = 14/146 (9%)
Query: 532 HQCLKSLGER-GNPQGQVDSLAIFYCLF---EMQDPAFVKQAVNLLQEANFHIIDNVDLV 587
H +KSL + P+ +++L + C + +D AF +A L E + + +++
Sbjct: 822 HSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDL----SFNVL 877
Query: 588 VSAYCLKYCSSLRKLCFSVQNVFKKEDEHSSTSDYSLICWHHICSVLTTSGHLRELQVQD 647
A C LR+ +Q + + TSD C + SVL+ S L+EL +Q
Sbjct: 878 TDAGAKHLCQRLRQPSCKLQRL--QLVSCGLTSD----CCQDLASVLSASPSLKELDLQQ 931
Query: 648 STLSESTFVTWCNQLRHPSCRLQKLG 673
+ L + C LRHP+C+L +LG
Sbjct: 932 NNLDDVGVRLLCEGLRHPACKLIRLG 957
>gi|21264320 NLR family, pyrin domain containing 6 [Homo sapiens]
Length = 892
Score = 301 bits (772), Expect = 2e-81
Identities = 243/854 (28%), Positives = 400/854 (46%), Gaps = 89/854 (10%)
Query: 11 LMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWN 70
L+ LEEL +E+ ++F+ L+ + + + IPW +++A +LA L + Y + A
Sbjct: 22 LLAALEELSQEQLKRFRHKLRDVGP--DGRSIPWGRLERADAVDLAEQLAQFYGPEPALE 79
Query: 71 ITLRIFQKMDRKDLCMKVMRER--------------TGYTKTYQAHAKQKFSRLWS---- 112
+ + ++ D +D+ ++ R + Y K Y+ H Q +R+
Sbjct: 80 VARKTLKRADARDVAAQLQERRLQRLGLGSGTLLSVSEYKKKYREHVLQLHARVKERNAR 139
Query: 113 ----SKSVTEIHLYFEEEVKQE----------------ECDHLDRLFAPKEAGKQPRTVI 152
+K T++ + E +E + +RLF E G++P TV+
Sbjct: 140 SVKITKRFTKLLIAPESAAPEEALGPAEEPEPGRARRSDTHTFNRLFRRDEEGRRPLTVV 199
Query: 153 IQGPQGIGKTTLLMKLMMAWSDNKIFRDRFLYTFYFCCRELRELPPT-SLADLISREWPD 211
+QGP GIGKT K++ W+ K+++ + + F+ C EL E P T SLADLI + PD
Sbjct: 200 LQGPAGIGKTMAAKKILYDWAAGKLYQGQVDFAFFMPCGELLERPGTRSLADLILDQCPD 259
Query: 212 PAAPITEIVSQPERLLFVIDSFEELQGGLNEPDSDLCGDLMEKRPVQVLLSSLLRKKMLP 271
AP+ ++++QP+RLLF++D +EL L P++ C D E +L LL K +LP
Sbjct: 260 RGAPVPQMLAQPQRLLFILDGADELPA-LGGPEAAPCTDPFEAASGARVLGGLLSKALLP 318
Query: 272 EASLLIAIKPVCPKELRDQVTISEIYQPRGFNESDRLVYFCCFFKDPKRAMEAFNLVRES 331
A LL+ + P L+ ++ + + RGF++ D+ YF FF+D +RA A+ V+E+
Sbjct: 319 TALLLVTTRAAAPGRLQGRLCSPQCAEVRGFSDKDKKKYFYKFFRDERRAERAYRFVKEN 378
Query: 332 EQLFSICQIPLLCWILCTSLKQEMQKGKDLALTCQSTTSVYSSFVFN-LFTPEGAEGPTP 390
E LF++C +P +CWI+CT L+Q+++ G+DL+ T ++TTSVY F+ + L + A+G P
Sbjct: 379 ETLFALCFVPFVCWIVCTVLRQQLELGRDLSRTSKTTTSVYLLFITSVLSSAPVADG--P 436
Query: 391 QTQHQLKALCSLAAEGMWTDTFEFCEDDLRRNGVVDADIPAL-LGTKILLKYGERESSYV 449
+ Q L+ LC LA EG+ +F E +L + + + + L L K L E E +Y
Sbjct: 437 RLQGDLRNLCRLAREGVLGRRAQFAEKELEQLELRGSKVQTLFLSKKELPGVLETEVTYQ 496
Query: 450 FLHVCIQEFCAALFYLLKSHLDHPHPAVRCVQELLVANFEKARRAHWIFLGCFLTGLLNK 509
F+ QEF AAL YLL+ P A V LL + + +H + FL GLL+
Sbjct: 497 FIDQSFQEFLAALSYLLEDG-GVPRTAAGGVGTLLRGDAQP--HSHLVLTTRFLFGLLSA 553
Query: 510 KEQEKLDAFFGFQLSQEIKQ------------------QIHQCLKSLGERGNPQGQVDS- 550
+ ++ FG +S+ +KQ ++ + K L + P+ + +
Sbjct: 554 ERMRDIERHFGCMVSERVKQEALRWVQGQGQGCPGVAPEVTEGAKGLEDTEEPEEEEEGE 613
Query: 551 -----LAIFYCLFEMQDPAFVKQAVNLLQEANFHIID--NVDLVVSAYCLKYCSSLRKL- 602
L + YCL+E Q+ AFV+QA+ E + +D+ V +YC++ C + + L
Sbjct: 614 EPNYPLELLYCLYETQEDAFVRQALCRFPELALQRVRFCRMDVAVLSYCVRCCPAGQALR 673
Query: 603 CFSVQNVFKKEDEHSSTSDYSLICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQL 662
S + V +E + S + + G Q L S +
Sbjct: 674 LISCRLVAAQEKKKKSLGK----------RLQASLGGGSSSQGTTKQLPASLLHPLFQAM 723
Query: 663 RHPSCRLQKLGINNVSFSGQSVL-LFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYP 721
P C L L +++ L E L P L L +LS +R L + L +P
Sbjct: 724 TDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSEGLAWP 783
Query: 722 AGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQLDTG-VPLLCEALCSPDTV 780
V+ + V + L G+L + LT L++S QL V LC L
Sbjct: 784 QCRVQTVR-VQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQHQGCG 842
Query: 781 LVYLMLAFCHLSEQ 794
L L LA LSEQ
Sbjct: 843 LQTLSLASVELSEQ 856
Score = 67.0 bits (162), Expect = 8e-11
Identities = 50/164 (30%), Positives = 77/164 (46%), Gaps = 9/164 (5%)
Query: 824 LKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQL 883
L L +A+ P C L SL L C + A C DL+ AL + L L + N + + G+++
Sbjct: 716 LHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRM 775
Query: 884 LCRALTHTDCRLEILGLE----ECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVV 939
L L CR++ + ++ + GL + L +L S L L+L+ L V
Sbjct: 776 LSEGLAWPQCRVQTVRVQLPDPQRGL-----QYLVGMLRQSPALTTLDLSGCQLPAPMVT 830
Query: 940 VLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTIT 983
LC L+H C LQ L L + E++ L A + P+L IT
Sbjct: 831 YLCAVLQHQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVIT 874
Score = 51.6 bits (122), Expect = 4e-06
Identities = 32/101 (31%), Positives = 47/101 (46%), Gaps = 1/101 (0%)
Query: 884 LCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCE 943
L +A+T C L L L C L C+DL+ L + L +L L N L G+ +L E
Sbjct: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
Query: 944 ALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITD 984
L P+C +Q + ++ D Q L ++P LT D
Sbjct: 779 GLAWPQCRVQTVRVQLPDPQRGLQ-YLVGMLRQSPALTTLD 818
Score = 51.2 bits (121), Expect = 5e-06
Identities = 41/147 (27%), Positives = 64/147 (43%), Gaps = 1/147 (0%)
Query: 770 LCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCE 829
L +A+ P L L L+ C L + C +SE L ++ L L N L + GL+ L E
Sbjct: 719 LFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHNRLSEAGLRMLSE 778
Query: 830 ALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALT 889
L P C + ++ V+ G + L L + L L + ++ V LC L
Sbjct: 779 GLAWPQCRVQTV-RVQLPDPQRGLQYLVGMLRQSPALTTLDLSGCQLPAPMVTYLCAVLQ 837
Query: 890 HTDCRLEILGLEECGLTSTCCKDLASV 916
H C L+ L L L+ ++L +V
Sbjct: 838 HQGCGLQTLSLASVELSEQSLQELQAV 864
Score = 46.2 bits (108), Expect = 2e-04
Identities = 45/172 (26%), Positives = 75/172 (43%), Gaps = 10/172 (5%)
Query: 702 TLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCN 761
T +L + L A+ P ++ L L +C L C L+ L LT L + N
Sbjct: 707 TTKQLPASLLHPLFQAMTDPLCHLSSLTLSHCKLPDAVCRDLSEALRAAPALTELGLLHN 766
Query: 762 QL-DTGVPLLCEAL----CSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSA 816
+L + G+ +L E L C TV V L ++ +Y+ ML ++ ++ LDLS
Sbjct: 767 RLSEAGLRMLSEGLAWPQCRVQTVRVQLPDP-----QRGLQYLVGMLRQSPALTTLDLSG 821
Query: 817 NVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKI 868
L + LC L+H C L +L L ++ ++L + + +L I
Sbjct: 822 CQLPAPMVTYLCAVLQHQGCGLQTLSLASVELSEQSLQELQAVKRAKPDLVI 873
>gi|28827807 NLR family, pyrin domain containing 10 [Homo sapiens]
Length = 655
Score = 226 bits (576), Expect = 8e-59
Identities = 159/543 (29%), Positives = 279/543 (51%), Gaps = 32/543 (5%)
Query: 11 LMWYLEELKKEEFRKFKEHLKQMTLQLELKQIPWTEVKKASREELANLLIKHYEEQQAWN 70
L+W L +L++ +F+K K +L+ MTL + E++ +LA LLI Y E++A
Sbjct: 13 LLWALSDLEENDFKKLKFYLRDMTLSEGQPPLARGELEGLIPVDLAELLISKYGEKEAVK 72
Query: 71 ITLRIFQKMDRKDL-------CM----KVMRERTGYTKTYQ-AHAKQKFSRLW-----SS 113
+ L+ + M+ +L C+ +V RE + +Q A +++++ SS
Sbjct: 73 VVLKGLKVMNLLELVDQLSHICLHDYREVYREHVRCLEEWQEAGVNGRYNQVLLVAKPSS 132
Query: 114 KSVTEIHLYFEEEVKQEECDHLDRLF-APKEAGKQPRTVIIQGPQGIGKTTLLMKLMMAW 172
+S + F E+ + E ++ LF + ++ P V++QG G GKTTL K+++ W
Sbjct: 133 ESPESLACPFPEQ--ELESVTVEALFDSGEKPSLAPSLVVLQGSAGTGKTTLARKMVLDW 190
Query: 173 SDNKIFRDRFLYTFYFCCRELRELPPTSLADLISREWPDPAAPITEIVSQPERLLFVIDS 232
+ ++ RF Y FY C+E+ L + L L+ D AP+TEI+ QPERLLF++D
Sbjct: 191 ATGTLYPGRFDYVFYVSCKEVVLLLESKLEQLLFWCCGDNQAPVTEILRQPERLLFILDG 250
Query: 233 FEELQGGLNEPDSDLCGDLMEKR---PVQVLLSSLLRKKMLPEASLLIAIKPVCPKELRD 289
F+ELQ E ++KR P + LL L+R+ LP SLLI +P+ + L
Sbjct: 251 FDELQRPFEEK--------LKKRGLSPKESLLHLLIRRHTLPTCSLLITTRPLALRNLEP 302
Query: 290 QVTISEIYQPRGFNESDRLVYFCCFFKDPKRAMEAFNLVRESEQLFSICQIPLLCWILCT 349
+ + GF+E +R YF +F D K+A AF++V++++ L+ CQ+P +CW++C+
Sbjct: 303 LLKQARHVHILGFSEEERARYFSSYFTDEKQADRAFDIVQKNDILYKACQVPGICWVVCS 362
Query: 350 SLKQEMQKGKDLALTCQSTTSVYSSFVFNLFTPEGAEGPTPQTQHQ-LKALCSLAAEGMW 408
L+ +M++GK + T +++T ++ ++V P+ G + ++H+ L++LCSLAAEG+
Sbjct: 363 WLQGQMERGKVVLETPRNSTDIFMAYVSTFLPPDDDGGCSELSRHRVLRSLCSLAAEGIQ 422
Query: 409 TDTFEFCEDDLRRNGVVDADIPALLGTKILLKYGERESSYVFLHVCIQEFCAALFYLLKS 468
F F E +LR++ + + A L + + Y F H+ Q+F A+ YL+K
Sbjct: 423 HQRFLFEEAELRKHNLDGPRLAAFLSSNDYQLGLAIKKFYSFRHISFQDFFHAMSYLVKE 482
Query: 469 HLDHPHPAVRCVQELLVANFEKARRAHWIFLGCFLTGLLNKKEQEKLDAFFGFQLSQEIK 528
R + L+ E+ FL + K L+ F F++S +
Sbjct: 483 DQSRLGKESRREVQRLLEVKEQEGNDEMTLTMQFLLDISKKDSFSNLELKFCFRISPCLA 542
Query: 529 QQI 531
Q +
Sbjct: 543 QDL 545
>gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Homo
sapiens]
Length = 287
Score = 188 bits (477), Expect = 2e-47
Identities = 107/258 (41%), Positives = 149/258 (57%), Gaps = 1/258 (0%)
Query: 726 KELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQLD-TGVPLLCEALCSPDTVLVYL 784
+ L L C +S CE L+ L NK LT +++S N + G+ LLCE L P L +
Sbjct: 28 QRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMI 87
Query: 785 MLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLV 844
L C L C+ ++ +L N + LDL+ N L+D GL+ LC+ L+HP C L +L L
Sbjct: 88 QLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLK 147
Query: 845 KCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECG 904
C +TAA C++LAS L NQ+L+ L + NE+GD+GV LLC L H C+L+ L L+ CG
Sbjct: 148 ICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCG 207
Query: 905 LTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDE 964
LT+ C++L L ++TL L LT N L TGV +LC+ L HP C L+VL L D ++
Sbjct: 208 LTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNK 267
Query: 965 ETQALLTAEEERNPNLTI 982
T + L A P L I
Sbjct: 268 MTHSRLAALRVTKPYLDI 285
Score = 106 bits (265), Expect = 9e-23
Identities = 78/246 (31%), Positives = 115/246 (46%), Gaps = 5/246 (2%)
Query: 630 ICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSF-SGQSVLLFE 688
+ + L + +L + + + + + C LRHP CRLQ + + SG +
Sbjct: 45 LSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMAS 104
Query: 689 VLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLT 748
VL P L L T L +R LC L +P ++ L L C L+ C+ LA L+
Sbjct: 105 VLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLS 164
Query: 749 NNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNK 807
N+ L L++S N+L D GV LLCE L P L L L C L+ + CE + L N+
Sbjct: 165 VNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFTLGINQ 224
Query: 808 SVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLK 867
++ L L+ N L D G++ LC+ L HP C L L L + LA+ ++
Sbjct: 225 TLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLFGMDLNKMTHSRLAALRVTK---P 281
Query: 868 ILQIGC 873
L IGC
Sbjct: 282 YLDIGC 287
Score = 65.1 bits (157), Expect = 3e-10
Identities = 31/91 (34%), Positives = 55/91 (60%)
Query: 894 RLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNTLDHTGVVVLCEALRHPECALQ 953
R + L L+ C ++S+ C+DL++ L +K L +++L+ N + G+++LCE LRHP+C LQ
Sbjct: 26 RRQRLWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQ 85
Query: 954 VLGLRKTDFDEETQALLTAEEERNPNLTITD 984
++ LRK + + + NP+L D
Sbjct: 86 MIQLRKCQLESGACQEMASVLGTNPHLVELD 116
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 184 bits (468), Expect = 3e-46
Identities = 116/355 (32%), Positives = 183/355 (51%), Gaps = 2/355 (0%)
Query: 630 ICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSVL-LFE 688
+ S L T L+EL + D+ L ++ C L P CRL+KL + S S S L
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 689 VLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLT 748
VL +PD K L+ + ++ +R LC L ++ L L +C ++ +C L G++
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 749 NNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNK 807
+ L L + N+L D G+ LC L P + L L + C ++ + C + +L +
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 808 SVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLK 867
S++ L L+ N L DEG + LCE L P C L+SL + C TAA C +S L N+ L
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 868 ILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLN 927
LQI N + D GV+ LC+ L L +L L +C ++ + C LA+ L + +L++L+
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Query: 928 LTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTI 982
L+ N L G++ L E++R P C L+ L L + EE + L A E+ P+L +
Sbjct: 405 LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 177 bits (450), Expect = 3e-44
Identities = 117/357 (32%), Positives = 175/357 (49%), Gaps = 2/357 (0%)
Query: 630 ICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSV-LLFE 688
I S L + L EL ++ + L + L+ PSC++QKL + N +G +L
Sbjct: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
Query: 689 VLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLT 748
L P L+ L + L ++ LC+ L P +++L L C LS CE LA +L
Sbjct: 108 TLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLR 167
Query: 749 NNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNK 807
L VS N + + GV +LC+ L L L L C ++ C + ++
Sbjct: 168 AKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKA 227
Query: 808 SVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLK 867
S+R L L +N L D G+ LC L HP L +L + +C ITA GC DL L + ++LK
Sbjct: 228 SLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLK 287
Query: 868 ILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLN 927
L + NE+GD G +LLC L C+LE L ++ C T+ CC +SVL ++ L +L
Sbjct: 288 ELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQ 347
Query: 928 LTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITD 984
++ N L+ GV LC+ L P L+VL L D + + + L A N +L D
Sbjct: 348 ISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Score = 167 bits (423), Expect = 5e-41
Identities = 104/330 (31%), Positives = 163/330 (49%), Gaps = 16/330 (4%)
Query: 640 LRELQVQDSTLSESTF------VTWCNQLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQ 693
++ L +Q LS++ + + C +R C L + ++S L
Sbjct: 5 IQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDIS---------SALRVN 55
Query: 694 PDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKL 753
P L L+ +L + + L P+ +++L+L NC L+ C VL+ L L
Sbjct: 56 PALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTL 115
Query: 754 TYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYL 812
L++S N L D G+ LLCE L P L L L +C LS CE ++ +L + L
Sbjct: 116 QELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKEL 175
Query: 813 DLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQIG 872
+S N + + G++ LC+ LK C L++L L C +T+ C DL + S +L+ L +G
Sbjct: 176 TVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALG 235
Query: 873 CNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNT 932
N++GDVG+ LC L H RL L + ECG+T+ C DL VL ++L++L+L N
Sbjct: 236 SNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNE 295
Query: 933 LDHTGVVVLCEALRHPECALQVLGLRKTDF 962
L G +LCE L P C L+ L ++ F
Sbjct: 296 LGDEGARLLCETLLEPGCQLESLWVKSCSF 325
Score = 34.3 bits (77), Expect = 0.60
Identities = 28/116 (24%), Positives = 49/116 (42%), Gaps = 1/116 (0%)
Query: 622 YSLICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSG 681
++ C H SVL + L ELQ+ ++ L ++ C L P L+ L + + S
Sbjct: 325 FTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSD 384
Query: 682 QSV-LLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLS 736
S L L L+ L + L I L +++ P +++L L + + S
Sbjct: 385 SSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWS 440
>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 184 bits (468), Expect = 3e-46
Identities = 116/355 (32%), Positives = 183/355 (51%), Gaps = 2/355 (0%)
Query: 630 ICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSVL-LFE 688
+ S L T L+EL + D+ L ++ C L P CRL+KL + S S S L
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 689 VLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLT 748
VL +PD K L+ + ++ +R LC L ++ L L +C ++ +C L G++
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 749 NNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNK 807
+ L L + N+L D G+ LC L P + L L + C ++ + C + +L +
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 808 SVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLK 867
S++ L L+ N L DEG + LCE L P C L+SL + C TAA C +S L N+ L
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 868 ILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLN 927
LQI N + D GV+ LC+ L L +L L +C ++ + C LA+ L + +L++L+
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Query: 928 LTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTI 982
L+ N L G++ L E++R P C L+ L L + EE + L A E+ P+L +
Sbjct: 405 LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 177 bits (450), Expect = 3e-44
Identities = 117/357 (32%), Positives = 175/357 (49%), Gaps = 2/357 (0%)
Query: 630 ICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSV-LLFE 688
I S L + L EL ++ + L + L+ PSC++QKL + N +G +L
Sbjct: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
Query: 689 VLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLT 748
L P L+ L + L ++ LC+ L P +++L L C LS CE LA +L
Sbjct: 108 TLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLR 167
Query: 749 NNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNK 807
L VS N + + GV +LC+ L L L L C ++ C + ++
Sbjct: 168 AKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKA 227
Query: 808 SVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLK 867
S+R L L +N L D G+ LC L HP L +L + +C ITA GC DL L + ++LK
Sbjct: 228 SLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLK 287
Query: 868 ILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLN 927
L + NE+GD G +LLC L C+LE L ++ C T+ CC +SVL ++ L +L
Sbjct: 288 ELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQ 347
Query: 928 LTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITD 984
++ N L+ GV LC+ L P L+VL L D + + + L A N +L D
Sbjct: 348 ISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Score = 167 bits (423), Expect = 5e-41
Identities = 104/330 (31%), Positives = 163/330 (49%), Gaps = 16/330 (4%)
Query: 640 LRELQVQDSTLSESTF------VTWCNQLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQ 693
++ L +Q LS++ + + C +R C L + ++S L
Sbjct: 5 IQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDIS---------SALRVN 55
Query: 694 PDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKL 753
P L L+ +L + + L P+ +++L+L NC L+ C VL+ L L
Sbjct: 56 PALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTL 115
Query: 754 TYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYL 812
L++S N L D G+ LLCE L P L L L +C LS CE ++ +L + L
Sbjct: 116 QELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKEL 175
Query: 813 DLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQIG 872
+S N + + G++ LC+ LK C L++L L C +T+ C DL + S +L+ L +G
Sbjct: 176 TVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALG 235
Query: 873 CNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNT 932
N++GDVG+ LC L H RL L + ECG+T+ C DL VL ++L++L+L N
Sbjct: 236 SNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNE 295
Query: 933 LDHTGVVVLCEALRHPECALQVLGLRKTDF 962
L G +LCE L P C L+ L ++ F
Sbjct: 296 LGDEGARLLCETLLEPGCQLESLWVKSCSF 325
Score = 34.3 bits (77), Expect = 0.60
Identities = 28/116 (24%), Positives = 49/116 (42%), Gaps = 1/116 (0%)
Query: 622 YSLICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSG 681
++ C H SVL + L ELQ+ ++ L ++ C L P L+ L + + S
Sbjct: 325 FTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSD 384
Query: 682 QSV-LLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLS 736
S L L L+ L + L I L +++ P +++L L + + S
Sbjct: 385 SSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWS 440
>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 184 bits (468), Expect = 3e-46
Identities = 116/355 (32%), Positives = 183/355 (51%), Gaps = 2/355 (0%)
Query: 630 ICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSVL-LFE 688
+ S L T L+EL + D+ L ++ C L P CRL+KL + S S S L
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 689 VLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLT 748
VL +PD K L+ + ++ +R LC L ++ L L +C ++ +C L G++
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 749 NNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNK 807
+ L L + N+L D G+ LC L P + L L + C ++ + C + +L +
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 808 SVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLK 867
S++ L L+ N L DEG + LCE L P C L+SL + C TAA C +S L N+ L
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 868 ILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLN 927
LQI N + D GV+ LC+ L L +L L +C ++ + C LA+ L + +L++L+
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Query: 928 LTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTI 982
L+ N L G++ L E++R P C L+ L L + EE + L A E+ P+L +
Sbjct: 405 LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 177 bits (450), Expect = 3e-44
Identities = 117/357 (32%), Positives = 175/357 (49%), Gaps = 2/357 (0%)
Query: 630 ICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSV-LLFE 688
I S L + L EL ++ + L + L+ PSC++QKL + N +G +L
Sbjct: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
Query: 689 VLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLT 748
L P L+ L + L ++ LC+ L P +++L L C LS CE LA +L
Sbjct: 108 TLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLR 167
Query: 749 NNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNK 807
L VS N + + GV +LC+ L L L L C ++ C + ++
Sbjct: 168 AKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKA 227
Query: 808 SVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLK 867
S+R L L +N L D G+ LC L HP L +L + +C ITA GC DL L + ++LK
Sbjct: 228 SLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLK 287
Query: 868 ILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLN 927
L + NE+GD G +LLC L C+LE L ++ C T+ CC +SVL ++ L +L
Sbjct: 288 ELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQ 347
Query: 928 LTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITD 984
++ N L+ GV LC+ L P L+VL L D + + + L A N +L D
Sbjct: 348 ISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Score = 167 bits (423), Expect = 5e-41
Identities = 104/330 (31%), Positives = 163/330 (49%), Gaps = 16/330 (4%)
Query: 640 LRELQVQDSTLSESTF------VTWCNQLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQ 693
++ L +Q LS++ + + C +R C L + ++S L
Sbjct: 5 IQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDIS---------SALRVN 55
Query: 694 PDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKL 753
P L L+ +L + + L P+ +++L+L NC L+ C VL+ L L
Sbjct: 56 PALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTL 115
Query: 754 TYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYL 812
L++S N L D G+ LLCE L P L L L +C LS CE ++ +L + L
Sbjct: 116 QELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKEL 175
Query: 813 DLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQIG 872
+S N + + G++ LC+ LK C L++L L C +T+ C DL + S +L+ L +G
Sbjct: 176 TVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALG 235
Query: 873 CNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNT 932
N++GDVG+ LC L H RL L + ECG+T+ C DL VL ++L++L+L N
Sbjct: 236 SNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNE 295
Query: 933 LDHTGVVVLCEALRHPECALQVLGLRKTDF 962
L G +LCE L P C L+ L ++ F
Sbjct: 296 LGDEGARLLCETLLEPGCQLESLWVKSCSF 325
Score = 34.3 bits (77), Expect = 0.60
Identities = 28/116 (24%), Positives = 49/116 (42%), Gaps = 1/116 (0%)
Query: 622 YSLICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSG 681
++ C H SVL + L ELQ+ ++ L ++ C L P L+ L + + S
Sbjct: 325 FTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSD 384
Query: 682 QSV-LLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLS 736
S L L L+ L + L I L +++ P +++L L + + S
Sbjct: 385 SSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWS 440
>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 184 bits (468), Expect = 3e-46
Identities = 116/355 (32%), Positives = 183/355 (51%), Gaps = 2/355 (0%)
Query: 630 ICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSVL-LFE 688
+ S L T L+EL + D+ L ++ C L P CRL+KL + S S S L
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 689 VLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLT 748
VL +PD K L+ + ++ +R LC L ++ L L +C ++ +C L G++
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 749 NNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNK 807
+ L L + N+L D G+ LC L P + L L + C ++ + C + +L +
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 808 SVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLK 867
S++ L L+ N L DEG + LCE L P C L+SL + C TAA C +S L N+ L
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 868 ILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLN 927
LQI N + D GV+ LC+ L L +L L +C ++ + C LA+ L + +L++L+
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Query: 928 LTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTI 982
L+ N L G++ L E++R P C L+ L L + EE + L A E+ P+L +
Sbjct: 405 LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 177 bits (450), Expect = 3e-44
Identities = 117/357 (32%), Positives = 175/357 (49%), Gaps = 2/357 (0%)
Query: 630 ICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSV-LLFE 688
I S L + L EL ++ + L + L+ PSC++QKL + N +G +L
Sbjct: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
Query: 689 VLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLT 748
L P L+ L + L ++ LC+ L P +++L L C LS CE LA +L
Sbjct: 108 TLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLR 167
Query: 749 NNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNK 807
L VS N + + GV +LC+ L L L L C ++ C + ++
Sbjct: 168 AKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKA 227
Query: 808 SVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLK 867
S+R L L +N L D G+ LC L HP L +L + +C ITA GC DL L + ++LK
Sbjct: 228 SLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLK 287
Query: 868 ILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLN 927
L + NE+GD G +LLC L C+LE L ++ C T+ CC +SVL ++ L +L
Sbjct: 288 ELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQ 347
Query: 928 LTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITD 984
++ N L+ GV LC+ L P L+VL L D + + + L A N +L D
Sbjct: 348 ISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Score = 167 bits (423), Expect = 5e-41
Identities = 104/330 (31%), Positives = 163/330 (49%), Gaps = 16/330 (4%)
Query: 640 LRELQVQDSTLSESTF------VTWCNQLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQ 693
++ L +Q LS++ + + C +R C L + ++S L
Sbjct: 5 IQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDIS---------SALRVN 55
Query: 694 PDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKL 753
P L L+ +L + + L P+ +++L+L NC L+ C VL+ L L
Sbjct: 56 PALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTL 115
Query: 754 TYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYL 812
L++S N L D G+ LLCE L P L L L +C LS CE ++ +L + L
Sbjct: 116 QELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKEL 175
Query: 813 DLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQIG 872
+S N + + G++ LC+ LK C L++L L C +T+ C DL + S +L+ L +G
Sbjct: 176 TVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALG 235
Query: 873 CNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNT 932
N++GDVG+ LC L H RL L + ECG+T+ C DL VL ++L++L+L N
Sbjct: 236 SNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNE 295
Query: 933 LDHTGVVVLCEALRHPECALQVLGLRKTDF 962
L G +LCE L P C L+ L ++ F
Sbjct: 296 LGDEGARLLCETLLEPGCQLESLWVKSCSF 325
Score = 34.3 bits (77), Expect = 0.60
Identities = 28/116 (24%), Positives = 49/116 (42%), Gaps = 1/116 (0%)
Query: 622 YSLICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSG 681
++ C H SVL + L ELQ+ ++ L ++ C L P L+ L + + S
Sbjct: 325 FTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSD 384
Query: 682 QSV-LLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLS 736
S L L L+ L + L I L +++ P +++L L + + S
Sbjct: 385 SSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWS 440
>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 184 bits (468), Expect = 3e-46
Identities = 116/355 (32%), Positives = 183/355 (51%), Gaps = 2/355 (0%)
Query: 630 ICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSVL-LFE 688
+ S L T L+EL + D+ L ++ C L P CRL+KL + S S S L
Sbjct: 105 LSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLAS 164
Query: 689 VLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLT 748
VL +PD K L+ + ++ +R LC L ++ L L +C ++ +C L G++
Sbjct: 165 VLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVA 224
Query: 749 NNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNK 807
+ L L + N+L D G+ LC L P + L L + C ++ + C + +L +
Sbjct: 225 SKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKE 284
Query: 808 SVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLK 867
S++ L L+ N L DEG + LCE L P C L+SL + C TAA C +S L N+ L
Sbjct: 285 SLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLL 344
Query: 868 ILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLN 927
LQI N + D GV+ LC+ L L +L L +C ++ + C LA+ L + +L++L+
Sbjct: 345 ELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Query: 928 LTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTI 982
L+ N L G++ L E++R P C L+ L L + EE + L A E+ P+L +
Sbjct: 405 LSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRV 459
Score = 177 bits (450), Expect = 3e-44
Identities = 117/357 (32%), Positives = 175/357 (49%), Gaps = 2/357 (0%)
Query: 630 ICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSGQSV-LLFE 688
I S L + L EL ++ + L + L+ PSC++QKL + N +G +L
Sbjct: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
Query: 689 VLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLT 748
L P L+ L + L ++ LC+ L P +++L L C LS CE LA +L
Sbjct: 108 TLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLR 167
Query: 749 NNKKLTYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNK 807
L VS N + + GV +LC+ L L L L C ++ C + ++
Sbjct: 168 AKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKA 227
Query: 808 SVRYLDLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLK 867
S+R L L +N L D G+ LC L HP L +L + +C ITA GC DL L + ++LK
Sbjct: 228 SLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLK 287
Query: 868 ILQIGCNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLN 927
L + NE+GD G +LLC L C+LE L ++ C T+ CC +SVL ++ L +L
Sbjct: 288 ELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQ 347
Query: 928 LTLNTLDHTGVVVLCEALRHPECALQVLGLRKTDFDEETQALLTAEEERNPNLTITD 984
++ N L+ GV LC+ L P L+VL L D + + + L A N +L D
Sbjct: 348 ISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELD 404
Score = 167 bits (423), Expect = 5e-41
Identities = 104/330 (31%), Positives = 163/330 (49%), Gaps = 16/330 (4%)
Query: 640 LRELQVQDSTLSESTF------VTWCNQLRHPSCRLQKLGINNVSFSGQSVLLFEVLFYQ 693
++ L +Q LS++ + + C +R C L + ++S L
Sbjct: 5 IQSLDIQCEELSDARWAELLPLLQQCQVVRLDDCGLTEARCKDIS---------SALRVN 55
Query: 694 PDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLSPIDCEVLAGLLTNNKKL 753
P L L+ +L + + L P+ +++L+L NC L+ C VL+ L L
Sbjct: 56 PALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTL 115
Query: 754 TYLNVSCNQL-DTGVPLLCEALCSPDTVLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYL 812
L++S N L D G+ LLCE L P L L L +C LS CE ++ +L + L
Sbjct: 116 QELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKEL 175
Query: 813 DLSANVLKDEGLKTLCEALKHPDCCLDSLCLVKCFITAAGCEDLASALISNQNLKILQIG 872
+S N + + G++ LC+ LK C L++L L C +T+ C DL + S +L+ L +G
Sbjct: 176 TVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALG 235
Query: 873 CNEIGDVGVQLLCRALTHTDCRLEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNT 932
N++GDVG+ LC L H RL L + ECG+T+ C DL VL ++L++L+L N
Sbjct: 236 SNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNE 295
Query: 933 LDHTGVVVLCEALRHPECALQVLGLRKTDF 962
L G +LCE L P C L+ L ++ F
Sbjct: 296 LGDEGARLLCETLLEPGCQLESLWVKSCSF 325
Score = 34.3 bits (77), Expect = 0.60
Identities = 28/116 (24%), Positives = 49/116 (42%), Gaps = 1/116 (0%)
Query: 622 YSLICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQKLGINNVSFSG 681
++ C H SVL + L ELQ+ ++ L ++ C L P L+ L + + S
Sbjct: 325 FTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSD 384
Query: 682 QSV-LLFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNYPAGNVKELALVNCHLS 736
S L L L+ L + L I L +++ P +++L L + + S
Sbjct: 385 SSCSSLAATLLANHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYDIYWS 440
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.323 0.137 0.420
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 38,025,586
Number of Sequences: 37866
Number of extensions: 1733229
Number of successful extensions: 5746
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 60
Number of HSP's successfully gapped in prelim test: 36
Number of HSP's that attempted gapping in prelim test: 4877
Number of HSP's gapped (non-prelim): 284
length of query: 994
length of database: 18,247,518
effective HSP length: 112
effective length of query: 882
effective length of database: 14,006,526
effective search space: 12353755932
effective search space used: 12353755932
T: 11
A: 40
X1: 16 ( 7.5 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (22.0 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.