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Search of human proteins with 194018478
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|194018478 TBC1 domain family, member 2B isoform a [Homo
sapiens]
(963 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens] 1943 0.0
gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens] 1818 0.0
gi|222352143 TBC1 domain family, member 2 [Homo sapiens] 612 e-175
gi|29648315 small G protein signaling modulator 3 [Homo sapiens] 204 2e-52
gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Ho... 155 1e-37
gi|38570101 TBC1 domain family, member 8B (with GRAM domain) iso... 147 4e-35
gi|156231067 TBC1 domain family, member 8 [Homo sapiens] 145 2e-34
gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens] 141 3e-33
gi|45597177 TBC1 domain family, member 9B (with GRAM domain) iso... 138 3e-32
gi|45597175 TBC1 domain family, member 9B (with GRAM domain) iso... 138 3e-32
gi|239750884 PREDICTED: hypothetical protein [Homo sapiens] 125 1e-28
gi|89038491 PREDICTED: hypothetical protein [Homo sapiens] 125 1e-28
gi|38348348 TBC1 domain family, member 10C [Homo sapiens] 125 2e-28
gi|21687020 ecotropic viral integration site 5-like isoform 2 [H... 124 4e-28
gi|169209032 PREDICTED: hypothetical protein [Homo sapiens] 124 4e-28
gi|13994322 TBC1 domain family, member 10A [Homo sapiens] 122 2e-27
gi|167614488 TBC1 domain family, member 10B [Homo sapiens] 122 2e-27
gi|229577000 ecotropic viral integration site 5-like isoform 1 [... 119 2e-26
gi|68299759 ecotropic viral integration site 5 [Homo sapiens] 115 3e-25
gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo... 111 4e-24
gi|239755853 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 109 1e-23
gi|239750365 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 109 1e-23
gi|239744669 PREDICTED: TBC1 domain family, member 30 [Homo sapi... 109 1e-23
gi|164519084 RAB GTPase activating protein 1 [Homo sapiens] 107 7e-23
gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member... 106 9e-23
gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens] 100 7e-21
gi|38570103 TBC1 domain family, member 8B (with GRAM domain) iso... 100 7e-21
gi|114688046 TBC1 domain family, member 4 [Homo sapiens] 100 7e-21
gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens] 99 1e-20
gi|14149985 TBC1 domain family, member 3F [Homo sapiens] 86 1e-16
>gi|194018478 TBC1 domain family, member 2B isoform a [Homo sapiens]
Length = 963
Score = 1943 bits (5033), Expect = 0.0
Identities = 963/963 (100%), Positives = 963/963 (100%)
Query: 1 MPGAGARAEEGGGGGEGAAQGAAAEPGAGPAREPARLCGYLQKLSGKGPLRGYRSRWFVF 60
MPGAGARAEEGGGGGEGAAQGAAAEPGAGPAREPARLCGYLQKLSGKGPLRGYRSRWFVF
Sbjct: 1 MPGAGARAEEGGGGGEGAAQGAAAEPGAGPAREPARLCGYLQKLSGKGPLRGYRSRWFVF 60
Query: 61 DARRCYLYYFKSPQDALPLGHLDIADACFSYQGPDEAAEPGTEPPAHFQVHSAGAVTVLK 120
DARRCYLYYFKSPQDALPLGHLDIADACFSYQGPDEAAEPGTEPPAHFQVHSAGAVTVLK
Sbjct: 61 DARRCYLYYFKSPQDALPLGHLDIADACFSYQGPDEAAEPGTEPPAHFQVHSAGAVTVLK 120
Query: 121 APNRQLMTYWLQELQQKRWEYCNSLDMVKWDSRTSPTPGDFPKGLVARDNTDLIYPHPNA 180
APNRQLMTYWLQELQQKRWEYCNSLDMVKWDSRTSPTPGDFPKGLVARDNTDLIYPHPNA
Sbjct: 121 APNRQLMTYWLQELQQKRWEYCNSLDMVKWDSRTSPTPGDFPKGLVARDNTDLIYPHPNA 180
Query: 181 SAEKARNVLAVETVPGELVGEQAANQPAPGHPNSINFYSLKQWGNELKNSMSSFRPGRGH 240
SAEKARNVLAVETVPGELVGEQAANQPAPGHPNSINFYSLKQWGNELKNSMSSFRPGRGH
Sbjct: 181 SAEKARNVLAVETVPGELVGEQAANQPAPGHPNSINFYSLKQWGNELKNSMSSFRPGRGH 240
Query: 241 NDSRRTVFYTNEEWELLDPTPKDLEESIVQEEKKKLTPEGNKGVTGSGFPFDFGRNPYKG 300
NDSRRTVFYTNEEWELLDPTPKDLEESIVQEEKKKLTPEGNKGVTGSGFPFDFGRNPYKG
Sbjct: 241 NDSRRTVFYTNEEWELLDPTPKDLEESIVQEEKKKLTPEGNKGVTGSGFPFDFGRNPYKG 300
Query: 301 KRPLKDIIGSYKNRHSSGDPSSEGTSGSGSVSIRKPASEMQLQVQSQQEELEQLKKDLSS 360
KRPLKDIIGSYKNRHSSGDPSSEGTSGSGSVSIRKPASEMQLQVQSQQEELEQLKKDLSS
Sbjct: 301 KRPLKDIIGSYKNRHSSGDPSSEGTSGSGSVSIRKPASEMQLQVQSQQEELEQLKKDLSS 360
Query: 361 QKELVRLLQQTVRSSQYDKYFTSSRLCEGVPKDTLELLHQKDDQILGLTSQLERFSLEKE 420
QKELVRLLQQTVRSSQYDKYFTSSRLCEGVPKDTLELLHQKDDQILGLTSQLERFSLEKE
Sbjct: 361 QKELVRLLQQTVRSSQYDKYFTSSRLCEGVPKDTLELLHQKDDQILGLTSQLERFSLEKE 420
Query: 421 SLQQEVRTLKSKVGELNEQLGMLMETIQAKDEVIIKLSEGEGNGPPPTVAPSSPSVVPVA 480
SLQQEVRTLKSKVGELNEQLGMLMETIQAKDEVIIKLSEGEGNGPPPTVAPSSPSVVPVA
Sbjct: 421 SLQQEVRTLKSKVGELNEQLGMLMETIQAKDEVIIKLSEGEGNGPPPTVAPSSPSVVPVA 480
Query: 481 RDQLELDRLKDNLQGYKTQNKFLNKEILELSALRRNAERRERDLMAKYSSLEAKLCQIES 540
RDQLELDRLKDNLQGYKTQNKFLNKEILELSALRRNAERRERDLMAKYSSLEAKLCQIES
Sbjct: 481 RDQLELDRLKDNLQGYKTQNKFLNKEILELSALRRNAERRERDLMAKYSSLEAKLCQIES 540
Query: 541 KYLILLQEMKTPVCSEDQGPTREVIAQLLEDALQVESQEQPEQAFVKPHLVSEYDIYGFR 600
KYLILLQEMKTPVCSEDQGPTREVIAQLLEDALQVESQEQPEQAFVKPHLVSEYDIYGFR
Sbjct: 541 KYLILLQEMKTPVCSEDQGPTREVIAQLLEDALQVESQEQPEQAFVKPHLVSEYDIYGFR 600
Query: 601 TVPEDDEEEKLVAKVRALDLKTLYLTENQEVSTGVKWENYFASTVNREMMCSPELKNLIR 660
TVPEDDEEEKLVAKVRALDLKTLYLTENQEVSTGVKWENYFASTVNREMMCSPELKNLIR
Sbjct: 601 TVPEDDEEEKLVAKVRALDLKTLYLTENQEVSTGVKWENYFASTVNREMMCSPELKNLIR 660
Query: 661 AGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELDLLRTLPN 720
AGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELDLLRTLPN
Sbjct: 661 AGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELDLLRTLPN 720
Query: 721 NKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFWCLVTIVE 780
NKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFWCLVTIVE
Sbjct: 721 NKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFWCLVTIVE 780
Query: 781 VFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVDSV 840
VFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVDSV
Sbjct: 781 VFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVDSV 840
Query: 841 VSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLRYFTRTILDARK 900
VSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLRYFTRTILDARK
Sbjct: 841 VSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLRYFTRTILDARK 900
Query: 901 LISISFGDLNPFPLRQIRNRRAYHLEKVRLELTELEAIREDFLRERDTSPDKGELVSDEE 960
LISISFGDLNPFPLRQIRNRRAYHLEKVRLELTELEAIREDFLRERDTSPDKGELVSDEE
Sbjct: 901 LISISFGDLNPFPLRQIRNRRAYHLEKVRLELTELEAIREDFLRERDTSPDKGELVSDEE 960
Query: 961 EDT 963
EDT
Sbjct: 961 EDT 963
>gi|194018476 TBC1 domain family, member 2B isoform b [Homo sapiens]
Length = 914
Score = 1818 bits (4710), Expect = 0.0
Identities = 899/899 (100%), Positives = 899/899 (100%)
Query: 1 MPGAGARAEEGGGGGEGAAQGAAAEPGAGPAREPARLCGYLQKLSGKGPLRGYRSRWFVF 60
MPGAGARAEEGGGGGEGAAQGAAAEPGAGPAREPARLCGYLQKLSGKGPLRGYRSRWFVF
Sbjct: 1 MPGAGARAEEGGGGGEGAAQGAAAEPGAGPAREPARLCGYLQKLSGKGPLRGYRSRWFVF 60
Query: 61 DARRCYLYYFKSPQDALPLGHLDIADACFSYQGPDEAAEPGTEPPAHFQVHSAGAVTVLK 120
DARRCYLYYFKSPQDALPLGHLDIADACFSYQGPDEAAEPGTEPPAHFQVHSAGAVTVLK
Sbjct: 61 DARRCYLYYFKSPQDALPLGHLDIADACFSYQGPDEAAEPGTEPPAHFQVHSAGAVTVLK 120
Query: 121 APNRQLMTYWLQELQQKRWEYCNSLDMVKWDSRTSPTPGDFPKGLVARDNTDLIYPHPNA 180
APNRQLMTYWLQELQQKRWEYCNSLDMVKWDSRTSPTPGDFPKGLVARDNTDLIYPHPNA
Sbjct: 121 APNRQLMTYWLQELQQKRWEYCNSLDMVKWDSRTSPTPGDFPKGLVARDNTDLIYPHPNA 180
Query: 181 SAEKARNVLAVETVPGELVGEQAANQPAPGHPNSINFYSLKQWGNELKNSMSSFRPGRGH 240
SAEKARNVLAVETVPGELVGEQAANQPAPGHPNSINFYSLKQWGNELKNSMSSFRPGRGH
Sbjct: 181 SAEKARNVLAVETVPGELVGEQAANQPAPGHPNSINFYSLKQWGNELKNSMSSFRPGRGH 240
Query: 241 NDSRRTVFYTNEEWELLDPTPKDLEESIVQEEKKKLTPEGNKGVTGSGFPFDFGRNPYKG 300
NDSRRTVFYTNEEWELLDPTPKDLEESIVQEEKKKLTPEGNKGVTGSGFPFDFGRNPYKG
Sbjct: 241 NDSRRTVFYTNEEWELLDPTPKDLEESIVQEEKKKLTPEGNKGVTGSGFPFDFGRNPYKG 300
Query: 301 KRPLKDIIGSYKNRHSSGDPSSEGTSGSGSVSIRKPASEMQLQVQSQQEELEQLKKDLSS 360
KRPLKDIIGSYKNRHSSGDPSSEGTSGSGSVSIRKPASEMQLQVQSQQEELEQLKKDLSS
Sbjct: 301 KRPLKDIIGSYKNRHSSGDPSSEGTSGSGSVSIRKPASEMQLQVQSQQEELEQLKKDLSS 360
Query: 361 QKELVRLLQQTVRSSQYDKYFTSSRLCEGVPKDTLELLHQKDDQILGLTSQLERFSLEKE 420
QKELVRLLQQTVRSSQYDKYFTSSRLCEGVPKDTLELLHQKDDQILGLTSQLERFSLEKE
Sbjct: 361 QKELVRLLQQTVRSSQYDKYFTSSRLCEGVPKDTLELLHQKDDQILGLTSQLERFSLEKE 420
Query: 421 SLQQEVRTLKSKVGELNEQLGMLMETIQAKDEVIIKLSEGEGNGPPPTVAPSSPSVVPVA 480
SLQQEVRTLKSKVGELNEQLGMLMETIQAKDEVIIKLSEGEGNGPPPTVAPSSPSVVPVA
Sbjct: 421 SLQQEVRTLKSKVGELNEQLGMLMETIQAKDEVIIKLSEGEGNGPPPTVAPSSPSVVPVA 480
Query: 481 RDQLELDRLKDNLQGYKTQNKFLNKEILELSALRRNAERRERDLMAKYSSLEAKLCQIES 540
RDQLELDRLKDNLQGYKTQNKFLNKEILELSALRRNAERRERDLMAKYSSLEAKLCQIES
Sbjct: 481 RDQLELDRLKDNLQGYKTQNKFLNKEILELSALRRNAERRERDLMAKYSSLEAKLCQIES 540
Query: 541 KYLILLQEMKTPVCSEDQGPTREVIAQLLEDALQVESQEQPEQAFVKPHLVSEYDIYGFR 600
KYLILLQEMKTPVCSEDQGPTREVIAQLLEDALQVESQEQPEQAFVKPHLVSEYDIYGFR
Sbjct: 541 KYLILLQEMKTPVCSEDQGPTREVIAQLLEDALQVESQEQPEQAFVKPHLVSEYDIYGFR 600
Query: 601 TVPEDDEEEKLVAKVRALDLKTLYLTENQEVSTGVKWENYFASTVNREMMCSPELKNLIR 660
TVPEDDEEEKLVAKVRALDLKTLYLTENQEVSTGVKWENYFASTVNREMMCSPELKNLIR
Sbjct: 601 TVPEDDEEEKLVAKVRALDLKTLYLTENQEVSTGVKWENYFASTVNREMMCSPELKNLIR 660
Query: 661 AGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELDLLRTLPN 720
AGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELDLLRTLPN
Sbjct: 661 AGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELDLLRTLPN 720
Query: 721 NKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFWCLVTIVE 780
NKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFWCLVTIVE
Sbjct: 721 NKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFWCLVTIVE 780
Query: 781 VFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVDSV 840
VFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVDSV
Sbjct: 781 VFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVDSV 840
Query: 841 VSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLRYFTRTILDAR 899
VSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLRYFTRTILDAR
Sbjct: 841 VSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLRYFTRTILDAR 899
>gi|222352143 TBC1 domain family, member 2 [Homo sapiens]
Length = 917
Score = 612 bits (1577), Expect = e-175
Identities = 380/966 (39%), Positives = 561/966 (58%), Gaps = 90/966 (9%)
Query: 1 MPGAGARAEEGGGGGEGAAQGAAAEPGAGPARE------------PARLCGYLQKLSGKG 48
M GAG A E G+ + +A +P P E P +LCGYL K GKG
Sbjct: 1 MEGAGENAPESSSSAPGSEE-SARDPQVPPPEEESGDCARSLEAVPKKLCGYLSKFGGKG 59
Query: 49 PLRGYRSRWFVFDARRCYLYYFKSPQDALPLGHLDIADACFSYQGPDEAAEPGTEPPAHF 108
P+RG++SRWF +D R+C LYY ++ QDA PL +D++ A F + AE G F
Sbjct: 60 PIRGWKSRWFFYDERKCQLYYSRTAQDANPLDSIDLSSAVFDCKAD---AEEGI-----F 111
Query: 109 QVHSAGAVTVLKAPNRQLMTYWLQELQQKRWEYCNSLDMVKWDSRTSPTPGDFPKGLVAR 168
++ + V LKA +Q M YWLQ+LQ KRWE+ NS P P P +A
Sbjct: 112 EIKTPSRVITLKAATKQAMLYWLQQLQMKRWEFHNS----------PPAPPATPDAALAG 161
Query: 169 DNTDLIYPHPNASAEKARNVLAVETVPGELVGEQAANQPAPGHPNSINFYSLKQWGNELK 228
+ L AE + V+T PG LVG AA QP P N SLK G E++
Sbjct: 162 NGPVLHLELGQEEAELEEFLCPVKTPPG-LVGVAAALQPFPALQN----ISLKHLGTEIQ 216
Query: 229 NSMSSFRPGRGHNDSRRTVFYTNEEWELLDPTPKDLEESIVQEEKKKLTPEGNKGVTGSG 288
N+M + R G+ ++ T +P +D +S E +++ P + T
Sbjct: 217 NTMHNIR---GNKQAQGTGH---------EPPGEDSPQS--GEPQREEQPLASDASTPGR 262
Query: 289 FPFDFGRNPYKGKRPLKDIIGSYK-NRHSSGDPS-SEGTSGSGSVSIRKPASEMQLQVQS 346
P D +P +P I + K R ++ P SEG + + + Q +V +
Sbjct: 263 EPED---SPKPAPKPSLTISFAQKAKRQNNTFPFFSEGITRNRTA---------QEKVAA 310
Query: 347 QQEELEQLKKDLSSQKELVRLLQQTVRSSQYDKYFTSSRLCEGVPKDTLELLHQKDDQIL 406
++++ L K+L SQKELV++L + + ++Q +K +S+ L KD LEL+ K QI
Sbjct: 311 LEQQVLMLTKELKSQKELVKILHKALEAAQQEKRASSAYLAAAEDKDRLELVRHKVRQIA 370
Query: 407 GLTSQLERFSLEKESLQQEVRTLKSKVGELNEQLGMLMETIQAKDEVIIKLSEG--EGNG 464
L ++E E+ESL + +V EL + + +LM+ AK +VI KLSE +
Sbjct: 371 ELGRRVEALEQERESLAHTASLREQQVQELQQHVQLLMDKNHAKQQVICKLSEKVTQDFT 430
Query: 465 PPPTVAPSSPSVV--PVARDQLELDRLKDNLQGYKTQNKFLNKEILELSALRRNAERRER 522
PP +P P Q +++ LKD+++ Y+TQN FLN EI +++ + R +E+
Sbjct: 431 HPPDQSPLRPDAANRDFLSQQGKIEHLKDDMEAYRTQNCFLNSEIHQVTKIWRKVAEKEK 490
Query: 523 DLMAKYSSLEAKLCQIESKYLILLQEMKTPVCSEDQGPTREVIAQLLEDALQVESQEQPE 582
L+ K + L+A+ CQ+ESKYL L+ ++ + ++ E++ QL+++ALQ E+ E
Sbjct: 491 ALLTKCAYLQARNCQVESKYLAGLRRLQEAL-GDEASECSELLRQLVQEALQWEAGEASS 549
Query: 583 QAFVKPHLVSEYDIYGFRTVPEDDEEE-KLVAKVRALDLKTLYLTENQEVSTGVKWENYF 641
+ ++ +S+YD YGF TVP+ + E+ KL+AK++AL+ ++ +L + V ++ E +
Sbjct: 550 DS-IELSPISKYDEYGFLTVPDYEVEDLKLLAKIQALESRSHHLLGLEAVDRPLR-ERWA 607
Query: 642 ASTVNREMMCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALE 701
A +++ S ELK L+RAG+P EHR +VW+W V H R +T PG +Q LL +
Sbjct: 608 ALG---DLVPSAELKQLLRAGVPREHRPRVWRWLV--HLRVQHLHT-PGCYQELLSRGQA 661
Query: 702 KQNPASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAV 761
+++PA++QIELDL RT PNNKH++CPTS KLR VLLAFSW+NP IGYCQGLNRL A+
Sbjct: 662 REHPAARQIELDLNRTFPNNKHFTCPTSSFPDKLRRVLLAFSWQNPTIGYCQGLNRLAAI 721
Query: 762 ALLYLEQED-AFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQY 820
ALL LE+E+ AFWCLV IVE MP DYY TL SQVDQRV +DL+SEKLPRL H Q+
Sbjct: 722 ALLVLEEEESAFWCLVAIVETIMPADYYCNTLTASQVDQRVLQDLLSEKLPRLMAHLGQH 781
Query: 821 KVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQD 880
VD +L+TFNWFLVVF DS++S+IL ++WD+FLYEG KY E+EIL+LQ+
Sbjct: 782 HVDLSLVTFNWFLVVFADSLISNILLRVWDAFLYEGT-----------KYNEKEILRLQN 830
Query: 881 SMSIFKYLRYFTRTILDARKLISISFGDLNPFPLRQIRNRRAYHLEKVRLELTELEAIRE 940
+ I++YLR+FT+TI ++RKL++I+F D+NPF ++Q+R R H E++ EL ELE ++
Sbjct: 831 GLEIYQYLRFFTKTISNSRKLMNIAFNDMNPFRMKQLRQLRMVHRERLEAELRELEQLKA 890
Query: 941 DFLRER 946
++L R
Sbjct: 891 EYLERR 896
>gi|29648315 small G protein signaling modulator 3 [Homo sapiens]
Length = 749
Score = 204 bits (520), Expect = 2e-52
Identities = 128/387 (33%), Positives = 197/387 (50%), Gaps = 30/387 (7%)
Query: 551 TPVCSEDQGPTREVIAQ--LLEDALQVESQEQPEQAFVKPHLVSEYDIYGFRTVPEDDEE 608
TP C T + Q L + + ES EQPE YD +GFR E+ +E
Sbjct: 6 TPACGPFSALTPSIWPQEILAKYTQKEESAEQPE---------FYYDEFGFRVYKEEGDE 56
Query: 609 --EKLVAKVRALD--------LKTLYLTENQEVSTGVKWENYFASTVNREMMCSPELKNL 658
L+A ++ L T N +V + W+ S E +L++L
Sbjct: 57 PGSSLLANSPLMEDAPQRLRWQAHLEFTHNHDVGD-LTWDKIAVSLPRSE-----KLRSL 110
Query: 659 IRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELDLLRTL 718
+ AGIPH R ++W +K ++ +++ + + A+KQIE DLLRT+
Sbjct: 111 VLAGIPHGMRPQLWMRLSGALQKKRNSELS---YREIVKNSSNDETIAAKQIEKDLLRTM 167
Query: 719 PNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFWCLVTI 778
P+N ++ S G+ +LR VL A +W P+IGYCQG + A LL+LE+EDAFW + I
Sbjct: 168 PSNACFASMGSIGVPRLRRVLRALAWLYPEIGYCQGTGMVAACLLLFLEEEDAFWMMSAI 227
Query: 779 VEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVD 838
+E +P Y++ TLLG Q DQRV R L+ + LPRL +++ ++ +LIT +WFL F
Sbjct: 228 IEDLLPASYFSTTLLGVQTDQRVLRHLIVQYLPRLDKLLQEHDIELSLITLHWFLTAFAS 287
Query: 839 SVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLRYFTRTILDA 898
V +L +IWD F YEG +V+F+ L + KEEE+++ ++S SIF L + DA
Sbjct: 288 VVDIKLLLRIWDLFFYEGSRVLFQLTLGMLHLKEEELIQSENSASIFNTLSDIPSQMEDA 347
Query: 899 RKLISISFGDLNPFPLRQIRNRRAYHL 925
L+ ++ + +R HL
Sbjct: 348 ELLLGVAMRLAGSLTDVAVETQRRKHL 374
>gi|139394668 TBC1 domain family, member 9 (with GRAM domain) [Homo
sapiens]
Length = 1266
Score = 155 bits (393), Expect = 1e-37
Identities = 99/285 (34%), Positives = 160/285 (56%), Gaps = 15/285 (5%)
Query: 637 WENYFASTVNREMMCSPE-LKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTL 695
W+ +FA M E + L+ GIP R ++W K T PG+++ L
Sbjct: 489 WKIHFAEYGQGICMYRTEKTRELVLKGIPESMRGELWLLLSGAINEKA---THPGYYEDL 545
Query: 696 LQKALEKQNPASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGL 755
++K++ K N A+++IE DL R+LP +H + GI LR VL A+++RNP+IGYCQ +
Sbjct: 546 VEKSMGKYNLATEEIERDLHRSLP--EHPAFQNEMGIAALRRVLTAYAFRNPNIGYCQAM 603
Query: 756 NRLVAVALLYLEQEDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHG 815
N + +V LLY ++E+AFW LV + E +P DYY ++G+ VDQ VF +L + +P+L+
Sbjct: 604 NIVTSVLLLYAKEEEAFWLLVALCERMLP-DYYNTRVVGALVDQGVFEELARDYVPQLYD 662
Query: 816 HFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEI 875
+ V T I+ +WFL +F+ + + + D F YEG KVIF+ ALA+ +++
Sbjct: 663 CMQDLGVIST-ISLSWFLTLFLSVMPFESAVVVVDCFFYEGIKVIFQLALAVLDANVDKL 721
Query: 876 LKLQD---SMSIF-KYLRYFTR---TILDARKLISISFGDLNPFP 913
L +D +M++ +YL T T+ L S+ D+ P+P
Sbjct: 722 LNCKDDGEAMTVLGRYLDSVTNKDSTLPPIPHLHSLLSDDVEPYP 766
>gi|38570101 TBC1 domain family, member 8B (with GRAM domain)
isoform a [Homo sapiens]
Length = 1120
Score = 147 bits (372), Expect = 4e-35
Identities = 99/324 (30%), Positives = 164/324 (50%), Gaps = 17/324 (5%)
Query: 570 EDALQVESQEQPEQAFVKPHLVSEYDIYGFRTVPEDDEEEKLVAKVRALDLKTLYLTENQ 629
E A+ ES E P F L S+ R + E L+ +L+TL +
Sbjct: 401 ELAISSESTE-PSDNFEVQSLTSQ------RECSKTVNTEALMTVFHPQNLETLNSKMLK 453
Query: 630 EVSTGVKWENYFASTVNR-EMMCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDN-T 687
E W+ FA M + + ++L+ GIP R ++W + D T
Sbjct: 454 EKMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWML----FSGAVNDMAT 509
Query: 688 EPGHFQTLLQKALEKQNPASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNP 747
P ++ +++++L N A+++IE DL R+LP + + T GI LR VL A+++RNP
Sbjct: 510 NPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDT--GISALRRVLTAYAYRNP 567
Query: 748 DIGYCQGLNRLVAVALLYLEQEDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMS 807
IGYCQ +N L +V LLY ++E+AFW LV + E +P DY+ + ++G+ VDQ VF +L+
Sbjct: 568 KIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCERMLP-DYFNRRIIGALVDQAVFEELIR 626
Query: 808 EKLPRLHGHFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALAL 867
+ LP+L H ++ ++ +WFL +F+ + + + D F Y+G K I + LA+
Sbjct: 627 DHLPQLTEHMTDMTF-FSSVSLSWFLTLFISVLPIESAVNVVDCFFYDGIKAILQLGLAI 685
Query: 868 FKYKEEEILKLQDSMSIFKYLRYF 891
Y +++L +D L F
Sbjct: 686 LDYNLDKLLTCKDDAEAVTALNRF 709
>gi|156231067 TBC1 domain family, member 8 [Homo sapiens]
Length = 1140
Score = 145 bits (366), Expect = 2e-34
Identities = 85/256 (33%), Positives = 135/256 (52%), Gaps = 8/256 (3%)
Query: 637 WENYFASTVNREMMCSPE-LKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTL 695
W ++F M E ++ L+ GIP R ++W D T + PG++ L
Sbjct: 479 WNDHFVEYGRTVCMFRTEKIRKLVAMGIPESLRGRLWLLFSDAVTDLA---SHPGYYGNL 535
Query: 696 LQKALEKQNPASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGL 755
++++L K +++IE DL R+LP +H + GI LR VL A++ RNP IGYCQ +
Sbjct: 536 VEESLGKCCLVTEEIERDLHRSLP--EHPAFQNETGIAALRRVLTAYAHRNPKIGYCQSM 593
Query: 756 NRLVAVALLYLEQEDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHG 815
N L +V LLY ++E+AFW LV + E +P DY+ ++G+QVDQ VF +L+ LP L
Sbjct: 594 NILTSVLLLYTKEEEAFWLLVAVCERMLP-DYFNHRVIGAQVDQSVFEELIKGHLPELAE 652
Query: 816 HFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEI 875
H ++ +WFL +F+ + + + D F Y+G K IF+ LA+ + E++
Sbjct: 653 HMNDLSA-LASVSLSWFLTLFLSIMPLESAVNVVDCFFYDGIKAIFQLGLAVLEANAEDL 711
Query: 876 LKLQDSMSIFKYLRYF 891
+D L F
Sbjct: 712 CSSKDDGQALMILSRF 727
>gi|118722351 growth hormone regulated TBC protein 1 [Homo sapiens]
Length = 336
Score = 141 bits (355), Expect = 3e-33
Identities = 85/245 (34%), Positives = 131/245 (53%), Gaps = 10/245 (4%)
Query: 652 SPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQ-I 710
S +K +R G+P EHR++VW + + PG++ LLQ ++NP + I
Sbjct: 58 SRTVKRYVRKGVPLEHRARVWMVLSGAQAQM---DQNPGYYHQLLQG---ERNPRLEDAI 111
Query: 711 ELDLLRTLPNNKHYSCPTSEGIQK-LRNVLLAFSWRNPDIGYCQGLNRLVAVALLYL-EQ 768
DL RT P+N + T +Q+ L NVLLA+ N +GYCQG+N + +L +
Sbjct: 112 RTDLNRTFPDNVKFRKTTDPCLQRTLYNVLLAYGHHNQGVGYCQGMNFIAGYLILITNNE 171
Query: 769 EDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLIT 828
E++FW L +V +P DYY+ +LG + DQ V +L+ KLP + E+ V +TL+
Sbjct: 172 EESFWLLDALVGRILP-DYYSPAMLGLKTDQEVLGELVRAKLPAVGALMERLGVLWTLLV 230
Query: 829 FNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYL 888
WF+ +FVD + + + +IWD EG K+IFR AL L K +E IL+ I
Sbjct: 231 SRWFICLFVDILPVETVLRIWDCLFNEGSKIIFRVALTLIKQHQELILEATSVPDICDKF 290
Query: 889 RYFTR 893
+ T+
Sbjct: 291 KQITK 295
>gi|45597177 TBC1 domain family, member 9B (with GRAM domain)
isoform b [Homo sapiens]
Length = 1233
Score = 138 bits (347), Expect = 3e-32
Identities = 82/232 (35%), Positives = 130/232 (56%), Gaps = 7/232 (3%)
Query: 649 MMCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASK 708
M + + + L+ GIP R ++W T PG++ L++K+ K + A++
Sbjct: 495 MYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMV---THPGYYAELVEKSTGKYSLATE 551
Query: 709 QIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQ 768
+IE DL R++P +H + GI LR VL A+++RNP IGYCQ +N + +V LLY +
Sbjct: 552 EIERDLHRSMP--EHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSE 609
Query: 769 EDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLIT 828
E+AFW LV + E +P DYY ++G+ VDQ +F +L + LP+L + V + I+
Sbjct: 610 EEAFWLLVALCERMLP-DYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGV-ISSIS 667
Query: 829 FNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQD 880
+WFL +F+ + + I D F YEG KVI + ALA+ E++L D
Sbjct: 668 LSWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSD 719
>gi|45597175 TBC1 domain family, member 9B (with GRAM domain)
isoform a [Homo sapiens]
Length = 1250
Score = 138 bits (347), Expect = 3e-32
Identities = 82/232 (35%), Positives = 130/232 (56%), Gaps = 7/232 (3%)
Query: 649 MMCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASK 708
M + + + L+ GIP R ++W T PG++ L++K+ K + A++
Sbjct: 495 MYRTAKTRALVLKGIPESLRGELWLLFSGAWNEMV---THPGYYAELVEKSTGKYSLATE 551
Query: 709 QIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQ 768
+IE DL R++P +H + GI LR VL A+++RNP IGYCQ +N + +V LLY +
Sbjct: 552 EIERDLHRSMP--EHPAFQNELGIAALRRVLTAYAFRNPTIGYCQAMNIVTSVLLLYGSE 609
Query: 769 EDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLIT 828
E+AFW LV + E +P DYY ++G+ VDQ +F +L + LP+L + V + I+
Sbjct: 610 EEAFWLLVALCERMLP-DYYNTRVVGALVDQGIFEELTRDFLPQLSEKMQDLGV-ISSIS 667
Query: 829 FNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQD 880
+WFL +F+ + + I D F YEG KVI + ALA+ E++L D
Sbjct: 668 LSWFLTLFLSVMPFESAVVIVDCFFYEGIKVILQVALAVLDANMEQLLGCSD 719
>gi|239750884 PREDICTED: hypothetical protein [Homo sapiens]
Length = 85
Score = 125 bits (315), Expect = 1e-28
Identities = 62/64 (96%), Positives = 63/64 (98%)
Query: 900 KLISISFGDLNPFPLRQIRNRRAYHLEKVRLELTELEAIREDFLRERDTSPDKGELVSDE 959
KLISISFGDLNPFP+RQIRNRRAYHLEKVRLELTELEAIREDFL ERDTSPDKGELVSDE
Sbjct: 22 KLISISFGDLNPFPVRQIRNRRAYHLEKVRLELTELEAIREDFLHERDTSPDKGELVSDE 81
Query: 960 EEDT 963
EEDT
Sbjct: 82 EEDT 85
>gi|89038491 PREDICTED: hypothetical protein [Homo sapiens]
Length = 85
Score = 125 bits (315), Expect = 1e-28
Identities = 62/64 (96%), Positives = 63/64 (98%)
Query: 900 KLISISFGDLNPFPLRQIRNRRAYHLEKVRLELTELEAIREDFLRERDTSPDKGELVSDE 959
KLISISFGDLNPFP+RQIRNRRAYHLEKVRLELTELEAIREDFL ERDTSPDKGELVSDE
Sbjct: 22 KLISISFGDLNPFPVRQIRNRRAYHLEKVRLELTELEAIREDFLHERDTSPDKGELVSDE 81
Query: 960 EEDT 963
EEDT
Sbjct: 82 EEDT 85
>gi|38348348 TBC1 domain family, member 10C [Homo sapiens]
Length = 446
Score = 125 bits (313), Expect = 2e-28
Identities = 77/235 (32%), Positives = 119/235 (50%), Gaps = 9/235 (3%)
Query: 635 VKWENYFASTVNREMMCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQT 694
V+ +++ T++R ++K R GIP R++ W H + PG +Q
Sbjct: 68 VEMTSHWEKTMSRRYK---KVKMQCRKGIPSALRARCWPLLCGAHVCQ---KNSPGTYQE 121
Query: 695 LLQKALEKQNPASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQG 754
L + + Q + I DL R P ++ + P G Q L VL A++ P+ GYCQ
Sbjct: 122 LAEAPGDPQ--WMETIGRDLHRQFPLHEMFVSPQGHGQQGLLQVLKAYTLYRPEQGYCQA 179
Query: 755 LNRLVAVALLYLEQEDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLH 814
+ AV L++L E+AFWCLV I EV++P YY + ++D VF L+ LP +H
Sbjct: 180 QGPVAAVLLMHLPPEEAFWCLVQICEVYLP-GYYGPHMEAVRLDAEVFMALLRRLLPHVH 238
Query: 815 GHFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFK 869
H +Q V L WFL +F S+ + ++WD+FL EG +V+FR L L +
Sbjct: 239 KHLQQVGVGPLLYLPEWFLCLFARSLPFPTVLRVWDAFLSEGARVLFRVGLTLVR 293
>gi|21687020 ecotropic viral integration site 5-like isoform 2 [Homo
sapiens]
Length = 794
Score = 124 bits (311), Expect = 4e-28
Identities = 84/317 (26%), Positives = 160/317 (50%), Gaps = 23/317 (7%)
Query: 655 LKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELDL 714
LK LIR GIPH R+ VW+ K+ + L+ +P K I D+
Sbjct: 108 LKELIRKGIPHHFRAIVWQLLCSATDMPVKNQ---------YSELLKMSSPCEKLIRRDI 158
Query: 715 LRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFWC 774
RT P ++ + S G + L NV+ A+S + ++GYCQG +V + L+ + +E+AF
Sbjct: 159 ARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCV 218
Query: 775 LVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLV 834
V +++ + R+ + ++ + F ++ E+LP L+ HF ++ +WFL
Sbjct: 219 FVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLT 278
Query: 835 VFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKL-QDSMSIFKYLRYFTR 893
+F+ + + +++D F+YEG +++FR LAL + + E+++L + MS +YF R
Sbjct: 279 LFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQLDMEGMS-----QYFQR 333
Query: 894 TI---LDA--RKLISISFG-DLNPFPLRQIRNRRAYHLEKVRLELTELEAIRED--FLRE 945
I D+ KL+ ++ NP ++++ A K E E++ +R + L++
Sbjct: 334 VIPHQFDSCPDKLVLKAYQVKYNPKKMKRLEKEYAAMKSKEMEEQIEIKRLRTENRLLKQ 393
Query: 946 RDTSPDKGELVSDEEED 962
R + +KG++ +E +
Sbjct: 394 RIETLEKGQVTRAQEAE 410
>gi|169209032 PREDICTED: hypothetical protein [Homo sapiens]
Length = 85
Score = 124 bits (311), Expect = 4e-28
Identities = 61/64 (95%), Positives = 63/64 (98%)
Query: 900 KLISISFGDLNPFPLRQIRNRRAYHLEKVRLELTELEAIREDFLRERDTSPDKGELVSDE 959
KLISISFGDLNPFP+RQIRN+RAYHLEKVRLELTELEAIREDFL ERDTSPDKGELVSDE
Sbjct: 22 KLISISFGDLNPFPVRQIRNQRAYHLEKVRLELTELEAIREDFLHERDTSPDKGELVSDE 81
Query: 960 EEDT 963
EEDT
Sbjct: 82 EEDT 85
>gi|13994322 TBC1 domain family, member 10A [Homo sapiens]
Length = 508
Score = 122 bits (305), Expect = 2e-27
Identities = 104/413 (25%), Positives = 166/413 (40%), Gaps = 51/413 (12%)
Query: 550 KTPVCSEDQGPTREVIAQLLEDALQVESQEQPEQAFVKPHLVSEYDIYGFRTVPEDDEEE 609
+ P E TRE +AQ + A E + D +GF + E
Sbjct: 11 RAPAAGESLSGTRESLAQGPDAATTDELSSLGSDSEANGFAERRIDKFGFIVGSQGAE-- 68
Query: 610 KLVAKVRALDLKTLYLTENQEVSTGVKWENYFASTVNREMMCSPELKNLIRAGIPHEHRS 669
+ + L+ L E++ + W+ + A + ++ + GIP R
Sbjct: 69 ---GALEEVPLEVLRQRESKWLDMLNNWDKWMAKKHKK-------IRLRCQKGIPPSLRG 118
Query: 670 KVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQ----IELDLLRTLPNNKHYS 725
+ W++ K K PG F L +P + IE DL R P ++ +
Sbjct: 119 RAWQYLSGG---KVKLQQNPGKFDEL------DMSPGDPKWLDVIERDLHRQFPFHEMFV 169
Query: 726 CPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFWCLVTIVEVFMPR 785
G Q L VL A++ P+ GYCQ + AV L+++ E AFWCLV I E ++P
Sbjct: 170 SRGGHGQQDLFRVLKAYTLYRPEEGYCQAQAPIAAVLLMHMPAEQAFWCLVQICEKYLP- 228
Query: 786 DYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVDSVVSDIL 845
YY++ L Q+D + L+ + P H H + K+D L WF+ F ++ +
Sbjct: 229 GYYSEKLEAIQLDGEILFSLLQKVSPVAHKHLSRQKIDPLLYMTEWFMCAFSRTLPWSSV 288
Query: 846 FKIWDSFLYEGPKVIFRFALALFKY---KEEEILKLQDSMSIFKYLRYFTRTILDARKLI 902
++WD F EG K+IFR L L K+ E++ Q + LR + I+ L+
Sbjct: 289 LRVWDMFFCEGVKIIFRVGLVLLKHALGSPEKVKACQGQYETIERLRSLSPKIMQEAFLV 348
Query: 903 SISFGDLNPFPLRQIRNRRAYHLEKVRLELTELEAIREDFLRERDTSPDKGEL 955
E V L +TE + RE ++ R +GEL
Sbjct: 349 Q----------------------EVVELPVTERQIEREHLIQLRRWQETRGEL 379
>gi|167614488 TBC1 domain family, member 10B [Homo sapiens]
Length = 808
Score = 122 bits (305), Expect = 2e-27
Identities = 75/256 (29%), Positives = 126/256 (49%), Gaps = 14/256 (5%)
Query: 635 VKWENYFASTVNREMMCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQT 694
+KW + F++ ++K R GIP R+K W++ + + N PG F+
Sbjct: 333 LKWLDMFSNWDKWLSRRFQKVKLRCRKGIPSSLRAKAWQY-LSNSKELLEQN--PGKFEE 389
Query: 695 LLQKALEKQNPASKQ----IELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIG 750
L ++ P + IE DL R P ++ ++ G Q L +L A++ PD G
Sbjct: 390 L------ERAPGDPKWLDVIEKDLHRQFPFHEMFAARGGHGQQDLYRILKAYTIYRPDEG 443
Query: 751 YCQGLNRLVAVALLYLEQEDAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKL 810
YCQ + AV L+++ E AFWCLV I + ++P YY+ L Q+D +F L+
Sbjct: 444 YCQAQAPVAAVLLMHMPAEQAFWCLVQICDKYLP-GYYSAGLEAIQLDGEIFFALLRRAS 502
Query: 811 PRLHGHFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKY 870
P H H + ++D L WF+ +F ++ + ++WD F EG K+IFR AL L ++
Sbjct: 503 PLAHRHLRRQRIDPVLYMTEWFMCIFARTLPWASVLRVWDMFFCEGVKIIFRVALVLLRH 562
Query: 871 KEEEILKLQDSMSIFK 886
+ KL+ +++
Sbjct: 563 TLGSVEKLRSCQGMYE 578
>gi|229577000 ecotropic viral integration site 5-like isoform 1
[Homo sapiens]
Length = 805
Score = 119 bits (297), Expect = 2e-26
Identities = 82/307 (26%), Positives = 154/307 (50%), Gaps = 23/307 (7%)
Query: 655 LKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELDL 714
LK LIR GIPH R+ VW+ K+ + L+ +P K I D+
Sbjct: 108 LKELIRKGIPHHFRAIVWQLLCSATDMPVKNQ---------YSELLKMSSPCEKLIRRDI 158
Query: 715 LRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFWC 774
RT P ++ + S G + L NV+ A+S + ++GYCQG +V + L+ + +E+AF
Sbjct: 159 ARTYPEHEFFKGQDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFCV 218
Query: 775 LVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLV 834
V +++ + R+ + ++ + F ++ E+LP L+ HF ++ +WFL
Sbjct: 219 FVRLMQEYRLRELFKPSMAELGLCIYQFEYMLQEQLPDLNTHFRSQSFHTSMYASSWFLT 278
Query: 835 VFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKL-QDSMSIFKYLRYFTR 893
+F+ + + +++D F+YEG +++FR LAL + + E+++L + MS +YF R
Sbjct: 279 LFLTTFPLPVATRVFDIFMYEGLEIVFRVGLALLQVNQAELMQLDMEGMS-----QYFQR 333
Query: 894 TI---LDA--RKLISISFG-DLNPFPLRQIRNRRAYHLEKVRLELTELEAIRED--FLRE 945
I D+ KL+ ++ NP ++++ A K E E++ +R + L++
Sbjct: 334 VIPHQFDSCPDKLVLKAYQVKYNPKKMKRLEKEYAAMKSKEMEEQIEIKRLRTENRLLKQ 393
Query: 946 RDTSPDK 952
R + +K
Sbjct: 394 RIETLEK 400
>gi|68299759 ecotropic viral integration site 5 [Homo sapiens]
Length = 810
Score = 115 bits (287), Expect = 3e-25
Identities = 78/314 (24%), Positives = 151/314 (48%), Gaps = 15/314 (4%)
Query: 654 ELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELD 713
++K L+ GIPH R+ VW+ + KD + L+ +P K I D
Sbjct: 155 QVKELVHKGIPHHFRAIVWQLLCSAQSMPIKDQ---------YSELLKMTSPCEKLIRRD 205
Query: 714 LLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFW 773
+ RT P + + S G + L NV+ A+S + ++GYCQG +V + L+ + +E+AF
Sbjct: 206 IARTYPEHNFFKEKDSLGQEVLFNVMKAYSLVDREVGYCQGSAFIVGLLLMQMPEEEAFC 265
Query: 774 CLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFL 833
V +++ + R+ + ++ + F ++ E LP L HF+ ++ +WFL
Sbjct: 266 VFVKLMQDYRLRELFKPSMAELGLCMYQFECMIQEHLPELFVHFQSQSFHTSMYASSWFL 325
Query: 834 VVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLRYFTR 893
+F+ + I +I+D F+ EG +++FR LAL + + E+++L D + ++ +
Sbjct: 326 TIFLTTFPLPIATRIFDIFMSEGLEIVFRVGLALLQMNQAELMQL-DMEGMLQHFQKVIP 384
Query: 894 TILDA--RKLISISFG-DLNPFPLRQIRNRRAYHLEKVRLELTELEAIRED--FLRERDT 948
D KLI ++ N ++++ K E E++ +R + L++R
Sbjct: 385 HQFDGVPDKLIQAAYQVKYNSKKMKKLEKEYTTIKTKEMEEQVEIKRLRTENRLLKQRIE 444
Query: 949 SPDKGELVSDEEED 962
+ +K + S+ ED
Sbjct: 445 TLEKHKCSSNYNED 458
>gi|78217386 RAB GTPase activating protein 1-like isoform A [Homo
sapiens]
Length = 815
Score = 111 bits (277), Expect = 4e-24
Identities = 74/238 (31%), Positives = 113/238 (47%), Gaps = 15/238 (6%)
Query: 655 LKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQK---ALEKQNPASKQIE 711
L L+++G+P R++VW+ H DN Q +L + + K + I
Sbjct: 531 LSTLVKSGVPEALRAEVWQLLAGCH-----DN------QAMLDRYRILITKDSAQESVIT 579
Query: 712 LDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDA 771
D+ RT P + ++ +G + L + A+S + DIGYCQG + L AV LL++ +E A
Sbjct: 580 RDIHRTFPAHDYFKDTGGDGQESLYKICKAYSVYDEDIGYCQGQSFLAAVLLLHMPEEQA 639
Query: 772 FWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNW 831
F LV I+ + RD Y LM E+LP LH HF ++ + W
Sbjct: 640 FCVLVKIMYDYGLRDLYRNNFEDLHCKFYQLERLMQEQLPDLHSHFSDLNLEAHMYASQW 699
Query: 832 FLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLR 889
FL +F ++F I D L EG +IF ALAL K +E++L+ D K+ R
Sbjct: 700 FLTLFTAKFPLCMVFHIIDLLLCEGLNIIFHVALALLKTSKEDLLQ-ADFEGALKFFR 756
>gi|239755853 PREDICTED: TBC1 domain family, member 30 [Homo
sapiens]
Length = 761
Score = 109 bits (273), Expect = 1e-23
Identities = 79/293 (26%), Positives = 137/293 (46%), Gaps = 31/293 (10%)
Query: 659 IRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELDLLRTL 718
+ GIP E R KVW D + + + +T+ E+ NP + + +++ L
Sbjct: 83 LSTGIPKEWRRKVWLTLADHYLHSIAIDWD----KTMRFTFNERSNPDDDSMGIQIVKDL 138
Query: 719 PNNKHYSCPTSEGIQK---LRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLE--QEDAFW 773
S E Q L+ VLLA++ N +GYCQG N L A+ L +E + DA
Sbjct: 139 HRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALK 198
Query: 774 CLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQ------------YK 821
++ +++ +P Y+ L VD VFRDL+ KLP L H + Y+
Sbjct: 199 IMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYE 258
Query: 822 VDYT-LITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQD 880
T + T WFL +F + + + KIWDS +EG ++I R +LA++ E+I +
Sbjct: 259 PPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQIECCET 318
Query: 881 SMSIFKYLRYFTRTILD-----ARKLISISFGDLNPFP---LRQIRNRRAYHL 925
+ + + T+ +L+ + +L+ + + PFP L ++R + Y++
Sbjct: 319 ADEFYSTMGRLTQEMLENDLLQSHELMQTVY-SMAPFPFPQLAELREKYTYNI 370
>gi|239750365 PREDICTED: TBC1 domain family, member 30 [Homo
sapiens]
Length = 761
Score = 109 bits (273), Expect = 1e-23
Identities = 79/293 (26%), Positives = 137/293 (46%), Gaps = 31/293 (10%)
Query: 659 IRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELDLLRTL 718
+ GIP E R KVW D + + + +T+ E+ NP + + +++ L
Sbjct: 83 LSTGIPKEWRRKVWLTLADHYLHSIAIDWD----KTMRFTFNERSNPDDDSMGIQIVKDL 138
Query: 719 PNNKHYSCPTSEGIQK---LRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLE--QEDAFW 773
S E Q L+ VLLA++ N +GYCQG N L A+ L +E + DA
Sbjct: 139 HRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALK 198
Query: 774 CLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQ------------YK 821
++ +++ +P Y+ L VD VFRDL+ KLP L H + Y+
Sbjct: 199 IMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYE 258
Query: 822 VDYT-LITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQD 880
T + T WFL +F + + + KIWDS +EG ++I R +LA++ E+I +
Sbjct: 259 PPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQIECCET 318
Query: 881 SMSIFKYLRYFTRTILD-----ARKLISISFGDLNPFP---LRQIRNRRAYHL 925
+ + + T+ +L+ + +L+ + + PFP L ++R + Y++
Sbjct: 319 ADEFYSTMGRLTQEMLENDLLQSHELMQTVY-SMAPFPFPQLAELREKYTYNI 370
>gi|239744669 PREDICTED: TBC1 domain family, member 30 [Homo
sapiens]
Length = 761
Score = 109 bits (273), Expect = 1e-23
Identities = 79/293 (26%), Positives = 137/293 (46%), Gaps = 31/293 (10%)
Query: 659 IRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELDLLRTL 718
+ GIP E R KVW D + + + +T+ E+ NP + + +++ L
Sbjct: 83 LSTGIPKEWRRKVWLTLADHYLHSIAIDWD----KTMRFTFNERSNPDDDSMGIQIVKDL 138
Query: 719 PNNKHYSCPTSEGIQK---LRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLE--QEDAFW 773
S E Q L+ VLLA++ N +GYCQG N L A+ L +E + DA
Sbjct: 139 HRTGCSSYCGQEAEQDRVVLKRVLLAYARWNKTVGYCQGFNILAALILEVMEGNEGDALK 198
Query: 774 CLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQ------------YK 821
++ +++ +P Y+ L VD VFRDL+ KLP L H + Y+
Sbjct: 199 IMIYLIDKVLPESYFVNNLRALSVDMAVFRDLLRMKLPELSQHLDTLQRTANKESGGGYE 258
Query: 822 VDYT-LITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQD 880
T + T WFL +F + + + KIWDS +EG ++I R +LA++ E+I +
Sbjct: 259 PPLTNVFTMQWFLTLFATCLPNQTVLKIWDSVFFEGSEIILRVSLAIWAKLGEQIECCET 318
Query: 881 SMSIFKYLRYFTRTILD-----ARKLISISFGDLNPFP---LRQIRNRRAYHL 925
+ + + T+ +L+ + +L+ + + PFP L ++R + Y++
Sbjct: 319 ADEFYSTMGRLTQEMLENDLLQSHELMQTVY-SMAPFPFPQLAELREKYTYNI 370
>gi|164519084 RAB GTPase activating protein 1 [Homo sapiens]
Length = 1069
Score = 107 bits (266), Expect = 7e-23
Identities = 84/317 (26%), Positives = 140/317 (44%), Gaps = 24/317 (7%)
Query: 654 ELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELD 713
+L +L+R G+P R +VW+ H H + + K++P I D
Sbjct: 558 QLSSLVRNGVPEALRGEVWQLLAGCHNND--------HLVEKYRILITKESPQDSAITRD 609
Query: 714 LLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFW 773
+ RT P + ++ +G L + A+S + +IGYCQG + L AV LL++ +E AF
Sbjct: 610 INRTFPAHDYFKDTGGDGQDSLYKICKAYSVYDEEIGYCQGQSFLAAVLLLHMPEEQAFS 669
Query: 774 CLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFL 833
LV I+ + R+ + + LM E +P L+ HF ++ + WFL
Sbjct: 670 VLVKIMFDYGLRELFKQNFEDLHCKFYQLERLMQEYIPDLYNHFLDISLEAHMYASQWFL 729
Query: 834 VVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLRYFT- 892
+F ++F I D L EG VIF AL L K ++++L L D K+ R
Sbjct: 730 TLFTAKFPLYMVFHIIDLLLCEGISVIFNVALGLLKTSKDDLL-LTDFEGALKFFRVQLP 788
Query: 893 ---RTILDARKLISISFGDLNPFPLRQIRNRRAYHLEKVRLELTELEAIRED----FLRE 945
R+ +A+KL+ ++ +I ++ EK + E +A +ED F RE
Sbjct: 789 KRYRSEENAKKLMELACN-------MKISQKKLKKYEKEYHTMREQQAQQEDPIERFERE 841
Query: 946 RDTSPDKGELVSDEEED 962
+ + E +D
Sbjct: 842 NRRLQEANMRLEQENDD 858
Score = 32.3 bits (72), Expect = 2.2
Identities = 21/99 (21%), Positives = 46/99 (46%), Gaps = 1/99 (1%)
Query: 352 EQLKKDLSSQK-ELVRLLQQTVRSSQYDKYFTSSRLCEGVPKDTLELLHQKDDQILGLTS 410
E+L+K ++ K E+ ++ Q+ + ++F +G+ L D++ L +
Sbjct: 946 ERLEKQQTANKVEIEKIRQKVDDCERCREFFNKEGRVKGISSTKEVLDEDTDEEKETLKN 1005
Query: 411 QLERFSLEKESLQQEVRTLKSKVGELNEQLGMLMETIQA 449
QL LE + ++ + K+ +L LG+ + +QA
Sbjct: 1006 QLREMELELAQTKLQLVEAECKIQDLEHHLGLALNEVQA 1044
>gi|50658061 TBC1 (tre-2/USP6, BUB2, cdc16) domain family, member 1
[Homo sapiens]
Length = 1168
Score = 106 bits (265), Expect = 9e-23
Identities = 72/295 (24%), Positives = 145/295 (49%), Gaps = 15/295 (5%)
Query: 605 DDEEEKLVAKVRALDLKTLYLTENQEVSTGVK-----WENYFASTVNREMMCSPE-LKNL 658
+ E +KL A L K L L + +E++ +K WE ++ ++ E + +
Sbjct: 738 EKENQKLQASENDLLNKRLKL-DYEEITPCLKEVTTVWEKMLSTPGRSKIKFDMEKMHSA 796
Query: 659 IRAGIPHEHRSKVWKWCVD----RHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELDL 714
+ G+P HR ++WK+ + +H K + ++ LL++ +Q+ I +DL
Sbjct: 797 VGQGVPRHHRGEIWKFLAEQFHLKHQFPSKQQPKDVPYKELLKQLTSQQH----AILIDL 852
Query: 715 LRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFWC 774
RT P + ++S G L N+L A+S + ++GYCQGL+ + + LL++ +E+AF
Sbjct: 853 GRTFPTHPYFSAQLGAGQLSLYNILKAYSLLDQEVGYCQGLSFVAGILLLHMSEEEAFKM 912
Query: 775 LVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWFLV 834
L ++ R Y ++ Q+ L+ + L+ H E++++ +L WFL
Sbjct: 913 LKFLMFDMGLRKQYRPDMIILQIQMYQLSRLLHDYHRDLYNHLEEHEIGPSLYAAPWFLT 972
Query: 835 VFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLR 889
+F + +++D +G +VIF+ AL+L + IL+ ++ +I +++
Sbjct: 973 MFASQFPLGFVARVFDMIFLQGTEVIFKVALSLLGSHKPLILQHENLETIVDFIK 1027
Score = 30.8 bits (68), Expect = 6.4
Identities = 38/148 (25%), Positives = 65/148 (43%), Gaps = 25/148 (16%)
Query: 365 VRLLQQTVRSSQYDKYFTSSRLCEGVPKDTLELLHQKDDQILGLTSQLERFSLEKE---S 421
V +QQT ++ ++LCEG P L+ LH+ ++I G+ S + L+K
Sbjct: 373 VAAVQQTAKAP--------AQLCEGCP---LQSLHKLCERIEGMNSSKTKLELQKHLTTL 421
Query: 422 LQQEVRTLKSKVGEL---NEQ------LGMLMETIQAKDEVIIKLSEGEGNGPPPTVAPS 472
QE T+ +V +L NEQ + L + K + I + GE A +
Sbjct: 422 TNQEQATIFEEVQKLRPRNEQRENELIISFLRCLYEEKQKEHIHI--GEMKQTSQMAAEN 479
Query: 473 SPSVVPVARDQLELDRLKDNLQGYKTQN 500
S +P + + LD LK+ + T++
Sbjct: 480 IGSELPPSATRFRLDMLKNKAKRSLTES 507
>gi|122937432 USP6 N-terminal like isoform 2 [Homo sapiens]
Length = 845
Score = 100 bits (249), Expect = 7e-21
Identities = 86/363 (23%), Positives = 168/363 (46%), Gaps = 35/363 (9%)
Query: 549 MKTPVCSEDQGPT--------REVIAQLLEDALQVESQEQP--EQAFVKPHLVSEYDIYG 598
M+T QG T ++V +L ++ ++ ++ E A ++P ++Y +Y
Sbjct: 1 MRTEAVVNSQGQTDYLTKDSDQDVALKLAQERAEIVAKYDRGREGAEIEPWEDADYLVYK 60
Query: 599 ----FRTVPEDDEEEKLVAKVRALDLKTLYLTENQEVSTGVKWENYFASTVNREMMCSPE 654
F + E++ + VA R L+ T+ ++ G WE Y N E +
Sbjct: 61 VTDRFGFLHEEELPDHNVAVERQKHLEIERTTKWLKMLKG--WEKY----KNTE-----K 109
Query: 655 LKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQKALEKQNPASKQIELDL 714
I GIP + R +VW ++ K K+ T + L+ +P +QI+LD+
Sbjct: 110 FHRRIYKGIPLQLRGEVWALLLE--IPKMKEETRD--LYSKLKHRARGCSPDIRQIDLDV 165
Query: 715 LRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQEDAFWC 774
RT ++ + Q L +VL A+S N ++GYCQG++++ A+ L+Y+ +EDAFW
Sbjct: 166 NRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQITALLLMYMNEEDAFWA 225
Query: 775 LVTIVE--VFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITFNWF 832
LV + ++ + Q ++++ L +L H + ++ + T WF
Sbjct: 226 LVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQHLDSQEIYTSFYTMKWF 285
Query: 833 LVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLRYFT 892
F+D + +IWD +++EG +V+ + + K ++ ++KL S+ + + +F
Sbjct: 286 FQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHLMKL----SMEELVEFFQ 341
Query: 893 RTI 895
T+
Sbjct: 342 ETL 344
>gi|38570103 TBC1 domain family, member 8B (with GRAM domain)
isoform b [Homo sapiens]
Length = 632
Score = 100 bits (249), Expect = 7e-21
Identities = 73/228 (32%), Positives = 116/228 (50%), Gaps = 16/228 (7%)
Query: 570 EDALQVESQEQPEQAFVKPHLVSEYDIYGFRTVPEDDEEEKLVAKVRALDLKTLYLTENQ 629
E A+ ES E P F L S+ R + E L+ +L+TL +
Sbjct: 401 ELAISSESTE-PSDNFEVQSLTSQ------RECSKTVNTEALMTVFHPQNLETLNSKMLK 453
Query: 630 EVSTGVKWENYFASTVNR-EMMCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDN-T 687
E W+ FA M + + ++L+ GIP R ++W + D T
Sbjct: 454 EKMKEQSWKILFAECGRGVSMFRTKKTRDLVVRGIPETLRGELWML----FSGAVNDMAT 509
Query: 688 EPGHFQTLLQKALEKQNPASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNP 747
P ++ +++++L N A+++IE DL R+LP + + T GI LR VL A+++RNP
Sbjct: 510 NPDYYTEVVEQSLGTCNLATEEIERDLRRSLPEHPAFQSDT--GISALRRVLTAYAYRNP 567
Query: 748 DIGYCQGLNRLVAVALLYLEQEDAFWCLVTIVEVFMPRDYYTKTLLGS 795
IGYCQ +N L +V LLY ++E+AFW LV + E +P DY+ + ++GS
Sbjct: 568 KIGYCQAMNILTSVLLLYAKEEEAFWLLVAVCERMLP-DYFNRRIIGS 614
>gi|114688046 TBC1 domain family, member 4 [Homo sapiens]
Length = 1298
Score = 100 bits (249), Expect = 7e-21
Identities = 60/240 (25%), Positives = 119/240 (49%), Gaps = 8/240 (3%)
Query: 654 ELKNLIRAGIPHEHRSKVWKWCVD----RHTRKFKDNTEPGHFQTLLQKALEKQNPASKQ 709
++ L++ G+P R ++W++ RH K ++ LL++ +Q+
Sbjct: 910 DIHTLLKEGVPKSRRGEIWQFLALQYRLRHRLPNKQQPPDISYKELLKQLTAQQHA---- 965
Query: 710 IELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNRLVAVALLYLEQE 769
I +DL RT P + ++S G L N+L A+S + ++GYCQG++ + V LL++ +E
Sbjct: 966 ILVDLGRTFPTHPYFSVQLGPGQLSLFNLLKAYSLLDKEVGYCQGISFVAGVLLLHMSEE 1025
Query: 770 DAFWCLVTIVEVFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHGHFEQYKVDYTLITF 829
AF L ++ R Y ++ Q+ L+ + L+ H E+ ++ +L
Sbjct: 1026 QAFEMLKFLMYDLGFRKQYRPDMMSLQIQMYQLSRLLHDYHRDLYNHLEENEISPSLYAA 1085
Query: 830 NWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEILKLQDSMSIFKYLR 889
WFL +F + +++D +G +VIF+ AL+L +E I++ + +I ++L+
Sbjct: 1086 PWFLTLFASQFSLGFVARVFDIIFLQGTEVIFKVALSLLSSQETLIMECESFENIVEFLK 1145
>gi|7661864 USP6 N-terminal like isoform 1 [Homo sapiens]
Length = 828
Score = 99.4 bits (246), Expect = 1e-20
Identities = 79/320 (24%), Positives = 151/320 (47%), Gaps = 25/320 (7%)
Query: 582 EQAFVKPHLVSEYDIYG----FRTVPEDDEEEKLVAKVRALDLKTLYLTENQEVSTGVKW 637
E A ++P ++Y +Y F + E++ + VA R L+ T+ ++ G W
Sbjct: 27 EGAEIEPWEDADYLVYKVTDRFGFLHEEELPDHNVAVERQKHLEIERTTKWLKMLKG--W 84
Query: 638 ENYFASTVNREMMCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTEPGHFQTLLQ 697
E Y N E + I GIP + R +VW ++ K K+ T + L+
Sbjct: 85 EKY----KNTE-----KFHRRIYKGIPLQLRGEVWALLLE--IPKMKEETRD--LYSKLK 131
Query: 698 KALEKQNPASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPDIGYCQGLNR 757
+P +QI+LD+ RT ++ + Q L +VL A+S N ++GYCQG+++
Sbjct: 132 HRARGCSPDIRQIDLDVNRTFRDHIMFRDRYGVKQQSLFHVLAAYSIYNTEVGYCQGMSQ 191
Query: 758 LVAVALLYLEQEDAFWCLVTIVE--VFMPRDYYTKTLLGSQVDQRVFRDLMSEKLPRLHG 815
+ A+ L+Y+ +EDAFW LV + ++ + Q ++++ L +L
Sbjct: 192 ITALLLMYMNEEDAFWALVKLFSGPKHAMHGFFVQGFPKLLRFQEHHEKILNKFLSKLKQ 251
Query: 816 HFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRFALALFKYKEEEI 875
H + ++ + T WF F+D + +IWD +++EG +V+ + + K ++ +
Sbjct: 252 HLDSQEIYTSFYTMKWFFQCFLDRTPFTLNLRIWDIYIFEGERVLTAMSYTILKLHKKHL 311
Query: 876 LKLQDSMSIFKYLRYFTRTI 895
+KL S+ + + +F T+
Sbjct: 312 MKL----SMEELVEFFQETL 327
>gi|14149985 TBC1 domain family, member 3F [Homo sapiens]
Length = 549
Score = 86.3 bits (212), Expect = 1e-16
Identities = 60/254 (23%), Positives = 122/254 (48%), Gaps = 14/254 (5%)
Query: 629 QEVSTGVKWENYFASTVNREMMCSPELKNLIRAGIPHEHRSKVWKWCVDRHTRKFKDNTE 688
+E+S KW + + S +L + G+P R +W ++ K K+
Sbjct: 70 REISRKSKWVDMLGDW--EKYKSSRKLIDRAYKGMPMNIRGPMWSVLLNTEEMKLKN--- 124
Query: 689 PGHFQTLLQKALEKQNPASKQIELDLLRTLPNNKHYSCPTSEGIQKLRNVLLAFSWRNPD 748
PG +Q + +K +K + ++I+ D+ TL + + ++L ++LLA+ NP+
Sbjct: 125 PGRYQIMKEKG-KKSSEHIQRIDRDVSGTLRKHIFFRDRYGTKQRELLHILLAYEEYNPE 183
Query: 749 IGYCQGLNRLVAVALLYLEQEDAFWCLVTIV--EVFMPRDYYTK---TLLGSQVDQRVFR 803
+GYC+ L+ + A+ LLYL +EDAFW LV ++ E + +++ T+ G Q Q
Sbjct: 184 VGYCRDLSHIAALFLLYLPEEDAFWALVQLLASERHSLQGFHSPNGGTVQGLQDQQ---E 240
Query: 804 DLMSEKLPRLHGHFEQYKVDYTLITFNWFLVVFVDSVVSDILFKIWDSFLYEGPKVIFRF 863
+++ P+ GH ++ + + + +D + + ++WD +L EG + +
Sbjct: 241 HVVATSQPKTMGHQDKKDLCGQCSPLGCLIRILIDGISLGLTLRLWDVYLVEGEQALMPI 300
Query: 864 ALALFKYKEEEILK 877
FK +++ + K
Sbjct: 301 TRIAFKVQQKRLTK 314
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.134 0.394
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 40,237,405
Number of Sequences: 37866
Number of extensions: 2007267
Number of successful extensions: 14599
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 176
Number of HSP's successfully gapped in prelim test: 505
Number of HSP's that attempted gapping in prelim test: 12566
Number of HSP's gapped (non-prelim): 2158
length of query: 963
length of database: 18,247,518
effective HSP length: 112
effective length of query: 851
effective length of database: 14,006,526
effective search space: 11919553626
effective search space used: 11919553626
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.