Guide to the Human Genome
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Search of human proteins with 192807332

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|192807332 arsenate resistance protein 2 isoform c [Homo
sapiens]
         (875 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|192807332 arsenate resistance protein 2 isoform c [Homo sapiens]  1816   0.0  
gi|58331218 arsenate resistance protein 2 isoform a [Homo sapiens]   1811   0.0  
gi|192807336 arsenate resistance protein 2 isoform e [Homo sapiens]  1800   0.0  
gi|192807334 arsenate resistance protein 2 isoform d [Homo sapiens]  1795   0.0  
gi|13540523 nucleosomal binding protein 1 [Homo sapiens]               81   4e-15
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    68   3e-11
gi|4759128 solute carrier family 24 (sodium/potassium/calcium ex...    66   1e-10
gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi...    65   4e-10
gi|210032580 SET domain containing 1B [Homo sapiens]                   64   6e-10
gi|221219020 NYD-SP11 protein [Homo sapiens]                           62   2e-09
gi|32484979 adaptor-related protein complex 3, beta 1 subunit [H...    62   3e-09
gi|69354671 ATP-binding cassette, sub-family F, member 1 isoform...    61   4e-09
gi|55741677 SET domain containing 1A [Homo sapiens]                    59   2e-08
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]            59   3e-08
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]            59   3e-08
gi|91206454 hypothetical protein LOC257415 isoform 2 [Homo sapiens]    59   3e-08
gi|91206456 hypothetical protein LOC257415 isoform 1 [Homo sapiens]    59   3e-08
gi|55741709 RNA binding motif protein 25 [Homo sapiens]                57   6e-08
gi|4557509 cylicin 2 [Homo sapiens]                                    57   6e-08
gi|46852388 cell-cycle and apoptosis regulatory protein 1 [Homo ...    57   6e-08
gi|156104891 general transcription factor IIF, polypeptide 1, 74...    57   7e-08
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]     57   1e-07
gi|27734775 hypothetical protein LOC286499 [Homo sapiens]              56   1e-07
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ...    56   2e-07
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ...    56   2e-07
gi|55956788 nucleolin [Homo sapiens]                                   55   2e-07
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              55   2e-07
gi|83921609 hypothetical protein LOC127254 [Homo sapiens]              55   3e-07
gi|168229156 NFKB activating protein [Homo sapiens]                    55   4e-07
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1...    55   4e-07

>gi|192807332 arsenate resistance protein 2 isoform c [Homo sapiens]
          Length = 875

 Score = 1816 bits (4704), Expect = 0.0
 Identities = 875/875 (100%), Positives = 875/875 (100%)

Query: 1   MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDR 60
           MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDR
Sbjct: 1   MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDR 60

Query: 61  NRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQPWGHPDV 120
           NRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQPWGHPDV
Sbjct: 61  NRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQPWGHPDV 120

Query: 121 HIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYNDYKLDFR 180
           HIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYNDYKLDFR
Sbjct: 121 HIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYNDYKLDFR 180

Query: 181 RQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWFDNLLLDI 240
           RQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWFDNLLLDI
Sbjct: 181 RQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWFDNLLLDI 240

Query: 241 DKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGER 300
           DKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGER
Sbjct: 241 DKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGER 300

Query: 301 KTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDD 360
           KTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDD
Sbjct: 301 KTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDD 360

Query: 361 SFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECKPRPLHKTC 420
           SFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECKPRPLHKTC
Sbjct: 361 SFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECKPRPLHKTC 420

Query: 421 SLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICWN 480
           SLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICWN
Sbjct: 421 SLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICWN 480

Query: 481 LQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWASE 540
           LQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWASE
Sbjct: 481 LQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWASE 540

Query: 541 PGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVER 600
           PGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVER
Sbjct: 541 PGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVER 600

Query: 601 DEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVLE 660
           DEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVLE
Sbjct: 601 DEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVLE 660

Query: 661 WQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGKK 720
           WQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGKK
Sbjct: 661 WQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGKK 720

Query: 721 FKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQILPPGL 780
           FKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQILPPGL
Sbjct: 721 FKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQILPPGL 780

Query: 781 TPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFRG 840
           TPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFRG
Sbjct: 781 TPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFRG 840

Query: 841 QGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF 875
           QGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF
Sbjct: 841 QGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF 875


>gi|58331218 arsenate resistance protein 2 isoform a [Homo sapiens]
          Length = 876

 Score = 1811 bits (4692), Expect = 0.0
 Identities = 875/876 (99%), Positives = 875/876 (99%), Gaps = 1/876 (0%)

Query: 1   MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDR 60
           MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDR
Sbjct: 1   MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDR 60

Query: 61  NRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQPWGHPDV 120
           NRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQPWGHPDV
Sbjct: 61  NRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQPWGHPDV 120

Query: 121 HIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYNDYKLDFR 180
           HIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYNDYKLDFR
Sbjct: 121 HIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYNDYKLDFR 180

Query: 181 RQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWFDNLLLDI 240
           RQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWFDNLLLDI
Sbjct: 181 RQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWFDNLLLDI 240

Query: 241 DKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGER 300
           DKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGER
Sbjct: 241 DKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGER 300

Query: 301 KTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDD 360
           KTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDD
Sbjct: 301 KTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDD 360

Query: 361 SFDEGSVSESESESESGQAEEEKEEAE-ALKEKEKPKEEEWEKPKDAAGLECKPRPLHKT 419
           SFDEGSVSESESESESGQAEEEKEEAE ALKEKEKPKEEEWEKPKDAAGLECKPRPLHKT
Sbjct: 361 SFDEGSVSESESESESGQAEEEKEEAEEALKEKEKPKEEEWEKPKDAAGLECKPRPLHKT 420

Query: 420 CSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICW 479
           CSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICW
Sbjct: 421 CSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICW 480

Query: 480 NLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWAS 539
           NLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWAS
Sbjct: 481 NLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWAS 540

Query: 540 EPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVE 599
           EPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVE
Sbjct: 541 EPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVE 600

Query: 600 RDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVL 659
           RDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVL
Sbjct: 601 RDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVL 660

Query: 660 EWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGK 719
           EWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGK
Sbjct: 661 EWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGK 720

Query: 720 KFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQILPPG 779
           KFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQILPPG
Sbjct: 721 KFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQILPPG 780

Query: 780 LTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFR 839
           LTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFR
Sbjct: 781 LTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFR 840

Query: 840 GQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF 875
           GQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF
Sbjct: 841 GQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF 876


>gi|192807336 arsenate resistance protein 2 isoform e [Homo sapiens]
          Length = 871

 Score = 1800 bits (4661), Expect = 0.0
 Identities = 870/875 (99%), Positives = 870/875 (99%), Gaps = 4/875 (0%)

Query: 1   MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDR 60
           MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDR
Sbjct: 1   MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDR 60

Query: 61  NRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQPWGHPDV 120
           NRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQPWGHPDV
Sbjct: 61  NRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQPWGHPDV 120

Query: 121 HIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYNDYKLDFR 180
           HIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYNDYKLDFR
Sbjct: 121 HIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYNDYKLDFR 180

Query: 181 RQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWFDNLLLDI 240
           RQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWFDNLLLDI
Sbjct: 181 RQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWFDNLLLDI 240

Query: 241 DKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGER 300
           DKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGER
Sbjct: 241 DKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGER 300

Query: 301 KTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDD 360
           KTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDD
Sbjct: 301 KTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDD 360

Query: 361 SFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECKPRPLHKTC 420
           SFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECKPRPLHKTC
Sbjct: 361 SFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECKPRPLHKTC 420

Query: 421 SLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICWN 480
           SLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICWN
Sbjct: 421 SLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICWN 480

Query: 481 LQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWASE 540
           LQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWASE
Sbjct: 481 LQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWASE 540

Query: 541 PGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVER 600
           PGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVER
Sbjct: 541 PGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVER 600

Query: 601 DEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVLE 660
           DEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVLE
Sbjct: 601 DEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVLE 660

Query: 661 WQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGKK 720
           WQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGKK
Sbjct: 661 WQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGKK 720

Query: 721 FKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQILPPGL 780
           FKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQ     L
Sbjct: 721 FKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQ----SL 776

Query: 781 TPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFRG 840
           TPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFRG
Sbjct: 777 TPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFRG 836

Query: 841 QGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF 875
           QGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF
Sbjct: 837 QGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF 871


>gi|192807334 arsenate resistance protein 2 isoform d [Homo sapiens]
          Length = 872

 Score = 1795 bits (4649), Expect = 0.0
 Identities = 870/876 (99%), Positives = 870/876 (99%), Gaps = 5/876 (0%)

Query: 1   MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDR 60
           MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDR
Sbjct: 1   MGDSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDR 60

Query: 61  NRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQPWGHPDV 120
           NRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQPWGHPDV
Sbjct: 61  NRRERFSPPRHELSPPQKRMRRDWDEHSSDPYHSGYEMPYAGGGGGPTYGPPQPWGHPDV 120

Query: 121 HIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYNDYKLDFR 180
           HIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYNDYKLDFR
Sbjct: 121 HIMQHHVLPIQARLGSIAEIDLGVPPPVMKTFKEFLLSLDDSVDETEAVKRYNDYKLDFR 180

Query: 181 RQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWFDNLLLDI 240
           RQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWFDNLLLDI
Sbjct: 181 RQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVFLSLMETGWFDNLLLDI 240

Query: 241 DKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGER 300
           DKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGER
Sbjct: 241 DKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGER 300

Query: 301 KTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDD 360
           KTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDD
Sbjct: 301 KTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDD 360

Query: 361 SFDEGSVSESESESESGQAEEEKEEAE-ALKEKEKPKEEEWEKPKDAAGLECKPRPLHKT 419
           SFDEGSVSESESESESGQAEEEKEEAE ALKEKEKPKEEEWEKPKDAAGLECKPRPLHKT
Sbjct: 361 SFDEGSVSESESESESGQAEEEKEEAEEALKEKEKPKEEEWEKPKDAAGLECKPRPLHKT 420

Query: 420 CSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICW 479
           CSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICW
Sbjct: 421 CSLFMRNIAPNISRAEIISLCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICW 480

Query: 480 NLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWAS 539
           NLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWAS
Sbjct: 481 NLQNIRLRECELSPGVNRDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWAS 540

Query: 540 EPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVE 599
           EPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVE
Sbjct: 541 EPGTPPLPTSLPSQNPILKNITDYLIEEVSAEEEELLGSSGGAPPEEPPKEGNPAEINVE 600

Query: 600 RDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVL 659
           RDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVL
Sbjct: 601 RDEKLIKVLDKLLLYLRIVHSLDYYNTCEYPNEDEMPNRCGIIHVRGPMPPNRISHGEVL 660

Query: 660 EWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGK 719
           EWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGK
Sbjct: 661 EWQKTFEEKLTPLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQELGKDKWLCPLSGK 720

Query: 720 KFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQILPPG 779
           KFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQ     
Sbjct: 721 KFKGPEFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQ----S 776

Query: 780 LTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFR 839
           LTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFR
Sbjct: 777 LTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPTGGPPYPHAPYGAGRGNYDAFR 836

Query: 840 GQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF 875
           GQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF
Sbjct: 837 GQGGYPGKPRNRMVRGDPRAIVEYRDLDAPDDVDFF 872


>gi|13540523 nucleosomal binding protein 1 [Homo sapiens]
          Length = 282

 Score = 81.3 bits (199), Expect = 4e-15
 Identities = 49/141 (34%), Positives = 78/141 (55%), Gaps = 8/141 (5%)

Query: 269 EQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDE---KKEDGKQAENDSSN-DDK 324
           ++E+EE+Q  + GE  K+++   G   G  ++  N+K E   +KEDGK+ E+   N +D 
Sbjct: 130 QKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKGNGEDG 189

Query: 325 TKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKE 384
            +K E + ++E++KE  + +  +  K++  K  G D      V E E E E G+ +E   
Sbjct: 190 KEKGEDEKEEEDRKETGDGKENEDGKEKGDKKEGKDV----KVKEDEKEREDGKEDEGGN 245

Query: 385 EAEALKEKEKPKEEEWEKPKD 405
           E EA KEKE  KEEE  K +D
Sbjct: 246 EEEAGKEKEDLKEEEEGKEED 266



 Score = 59.3 bits (142), Expect = 2e-08
 Identities = 39/152 (25%), Positives = 78/152 (51%), Gaps = 22/152 (14%)

Query: 256 KMEGGTEN-DLRILEQEEEEEQAGKPGEPSKKEE----GRAGAGLGDGERKTNDKDEKKE 310
           K E G E+ D +  E  +E++   + GE +K++E    G  G G G+  ++  + ++++E
Sbjct: 141 KGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKGNGEDGKEKGEDEKEEE 200

Query: 311 DGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSES 370
           D K+  +   N+D  +K +    K+ K ++ EKE                  ++G   E 
Sbjct: 201 DRKETGDGKENEDGKEKGDKKEGKDVKVKEDEKER-----------------EDGKEDEG 243

Query: 371 ESESESGQAEEEKEEAEALKEKEKPKEEEWEK 402
            +E E+G+ +E+ +E E  KE+++ KE++ +K
Sbjct: 244 GNEEEAGKEKEDLKEEEEGKEEDEIKEDDGKK 275



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 31/102 (30%), Positives = 53/102 (51%), Gaps = 6/102 (5%)

Query: 258 EGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEK-KEDGKQAE 316
           +G  E+     E E+EEE   + G+  + E+G+      +G+     +DEK +EDGK  E
Sbjct: 183 KGNGEDGKEKGEDEKEEEDRKETGDGKENEDGKEKGDKKEGKDVKVKEDEKEREDGK--E 240

Query: 317 NDSSNDDKTKKSEGD-GDKEEKKEDSEKEAKKSSKKRNRKHS 357
           ++  N+++  K + D  ++EE KE  E E K+   K+    S
Sbjct: 241 DEGGNEEEAGKEKEDLKEEEEGKE--EDEIKEDDGKKEEPQS 280



 Score = 38.5 bits (88), Expect = 0.027
 Identities = 32/148 (21%), Positives = 58/148 (39%), Gaps = 4/148 (2%)

Query: 267 ILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTK 326
           + E ++E        E +K  E +        +     K+E  ED  +   +       +
Sbjct: 63  VAETKQEAVVEEDYNENAKNGEAKITEAPASEKEIVEVKEENIEDATEKGGEKKEAVAAE 122

Query: 327 KSEGDGDKEEKKEDSEK---EAKKSSKKRNRKHSGDDSFDEGSVSESESESESG-QAEEE 382
               + D++E +ED  +   EA K  K    +  G +  +     E   E E G + E+ 
Sbjct: 123 VKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDG 182

Query: 383 KEEAEALKEKEKPKEEEWEKPKDAAGLE 410
           K   E  KEK + ++EE ++ +   G E
Sbjct: 183 KGNGEDGKEKGEDEKEEEDRKETGDGKE 210


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
           sapiens]
          Length = 1152

 Score = 68.2 bits (165), Expect = 3e-11
 Identities = 40/134 (29%), Positives = 69/134 (51%), Gaps = 5/134 (3%)

Query: 270 QEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSE 329
           +EEE E   + GE   +EEG  G G  +GE    + +E++ +G + E +   + + ++ E
Sbjct: 843 EEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEG-EGEEEGEGEGEEEEGE 901

Query: 330 GDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVS----ESESESESGQAEEEKEE 385
           G+G++E + E  E+E +   ++   +  G+   +EG       E E E E G+ E E+EE
Sbjct: 902 GEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEE 961

Query: 386 AEALKEKEKPKEEE 399
            E   E+E   E E
Sbjct: 962 GEGEGEEEGEGEGE 975



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 42/140 (30%), Positives = 75/140 (53%), Gaps = 7/140 (5%)

Query: 269 EQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKE---DGKQAENDSSNDDKT 325
           EQE++E + G   E +++ E       G+GE +  D++E++E   +GK+       + + 
Sbjct: 709 EQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGER 768

Query: 326 KKSEGDGDKEE---KKEDSEKEAKK-SSKKRNRKHSGDDSFDEGSVSESESESESGQAEE 381
           +K EG+  KEE   K+E  E+E  +   ++   +  G++  + G V   E E   G+ EE
Sbjct: 769 EKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREE 828

Query: 382 EKEEAEALKEKEKPKEEEWE 401
           E+EE E  +E+ + +EEE E
Sbjct: 829 EEEEGEGEEEEGEGEEEEGE 848



 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 46/155 (29%), Positives = 76/155 (49%), Gaps = 11/155 (7%)

Query: 258  EGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKE------- 310
            EG  E +    E E EEE+    GE   + EG    G G+GE +   + E++E       
Sbjct: 864  EGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEE 923

Query: 311  DGKQAENDSSNDD---KTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSV 367
            +G++ E +   ++   + +  EG+G++EE + + E+E  +   +   +  G++   EG  
Sbjct: 924  EGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEE 983

Query: 368  SESESESESGQAEEE-KEEAEALKEKEKPKEEEWE 401
             E E E E  + EEE +EE E  +E E   EEE E
Sbjct: 984  EEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEE 1018



 Score = 67.0 bits (162), Expect = 7e-11
 Identities = 42/143 (29%), Positives = 68/143 (47%), Gaps = 10/143 (6%)

Query: 256 KMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQA 315
           K EGG        E E  E + GK     ++EEG      G+GE +  + +E++ +GK  
Sbjct: 808 KEEGG--------EVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGE 859

Query: 316 ENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESE 375
           E     + + +  EG+G+ EE  E+ E E ++  +    +  G+   +E    E E E  
Sbjct: 860 EEGEEGEGEEEGEEGEGEGEE--EEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEG 917

Query: 376 SGQAEEEKEEAEALKEKEKPKEE 398
            G+ EEE EE E   E+E+ + E
Sbjct: 918 EGKGEEEGEEGEGEGEEEEGEGE 940



 Score = 67.0 bits (162), Expect = 7e-11
 Identities = 45/156 (28%), Positives = 78/156 (50%), Gaps = 12/156 (7%)

Query: 258  EGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTND---KDEKKEDGKQ 314
            EG  E +    E EEE E+    GE  + E      G G+GE +  +   ++E + +G++
Sbjct: 855  EGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEE 914

Query: 315  AENDSSNDDKTKKSEGDGDKEE--------KKEDSEKEAKKSSKKRNRKHSGDDSFD-EG 365
             E +   +++ ++ EG+G++EE        + E  E+E +   ++   +  G++  + EG
Sbjct: 915  EEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEG 974

Query: 366  SVSESESESESGQAEEEKEEAEALKEKEKPKEEEWE 401
               E E E E G+ E E+EE E   E+E   EEE E
Sbjct: 975  EEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGE 1010



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 42/156 (26%), Positives = 78/156 (50%), Gaps = 2/156 (1%)

Query: 256 KMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQA 315
           +ME G E +    E+EE + +  +  E   KEEG      G+ E++  ++ +++  GK+ 
Sbjct: 726 EMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEE 785

Query: 316 ENDSSNDD-KTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESES 374
           + +   D  + ++ E +G  EEK+E  E E  +  + +  +   ++   EG   E E E 
Sbjct: 786 KGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEE-GEGEEEEGEGEE 844

Query: 375 ESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLE 410
           E G+ EEE+ E +  +E E+ + EE  +  +  G E
Sbjct: 845 EEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEE 880



 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 43/148 (29%), Positives = 73/148 (49%), Gaps = 5/148 (3%)

Query: 258 EGGTENDLRILEQEEEEEQAGKPGE--PSKKEEGRAGAGLGDG-ERKTNDKDEKKEDGKQ 314
           EG  E +   +E E E+E+  +  E    K+E+G      G+G E +T  + E+KE+G +
Sbjct: 754 EGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGE 813

Query: 315 AENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESES 374
            E     + K ++ E + + E ++E+ E E ++   +        +  +EG   E E E 
Sbjct: 814 VEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGE--EEGEEGEGEEEG 871

Query: 375 ESGQAEEEKEEAEALKEKEKPKEEEWEK 402
           E G+ E E+EE E   E+E   E E E+
Sbjct: 872 EEGEGEGEEEEGEGEGEEEGEGEGEEEE 899



 Score = 65.1 bits (157), Expect = 3e-10
 Identities = 43/159 (27%), Positives = 78/159 (49%), Gaps = 9/159 (5%)

Query: 258  EGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDG----- 312
            EG  E +     + EEEE  GK  E  ++ EG      G+GE +  + + ++E+G     
Sbjct: 899  EGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGE 958

Query: 313  -KQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESE 371
             ++ E +   + + +  EG+G+ EE++ + E E ++  ++   +  G+   +EG     E
Sbjct: 959  EEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGE---EEGEGEGEE 1015

Query: 372  SESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLE 410
             E    + E E EE E   E+E+ +EE  E+ K+  G E
Sbjct: 1016 EEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEE 1054



 Score = 64.3 bits (155), Expect = 5e-10
 Identities = 50/174 (28%), Positives = 81/174 (46%), Gaps = 16/174 (9%)

Query: 255 IKMEGGTENDLRILEQE---EEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDE-KKE 310
           +K+ GG +    IL  +   + E   GK     + E+G  G G G  E  ++  +  + E
Sbjct: 613 VKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDE 672

Query: 311 DGKQAENDSSNDDKTKKSEGD---GDKEE-KKEDSEKEAKKSSKKRNRKHSGDDSFDEGS 366
           + ++ E D    +  +  EG+    +KEE KK D E++ +K  ++ ++K    +  + G 
Sbjct: 673 EREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGE 732

Query: 367 VSESESESESGQAEEE-------KEEAEALK-EKEKPKEEEWEKPKDAAGLECK 412
               E E E G  EEE       KEE E  + E E+ KEE   K ++ AG E K
Sbjct: 733 EEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEK 786



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 39/160 (24%), Positives = 81/160 (50%), Gaps = 17/160 (10%)

Query: 256 KMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRA---GAGLGDGERKTNDKDEKKEDG 312
           +ME   E +  + E+EE +++ G+  E  ++E+G        + +G  + + + E++E  
Sbjct: 685 EMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGD 744

Query: 313 KQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESES 372
           ++ E +   + K    EG+G++ E + + E+  +K  ++  ++  G++  D+G   E E+
Sbjct: 745 REEEEEKEGEGK---EEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEET 801

Query: 373 ES-----------ESGQAEEEKEEAEALKEKEKPKEEEWE 401
           E            E G+ EE K E E  +E+ + +EEE E
Sbjct: 802 EGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGE 841



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 38/134 (28%), Positives = 72/134 (53%), Gaps = 12/134 (8%)

Query: 269  EQEEEEEQAGKPGEPSKKEEGRAGAGLGD-GERKTNDKDEKKEDGK-----QAENDSSND 322
            E EEE E  G+ GE   +EE   G G  + GE +  ++ E +E+G+     + E +   +
Sbjct: 965  EGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGE 1024

Query: 323  DKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEE 382
             + ++ EG+G++EE +E+ E+  K+   + NR++  ++  +EG         E+G+ E E
Sbjct: 1025 VEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKY------QETGEEENE 1078

Query: 383  KEEAEALKEKEKPK 396
            +++ E  K+  K K
Sbjct: 1079 RQDGEEYKKVSKIK 1092



 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 46/164 (28%), Positives = 79/164 (48%), Gaps = 19/164 (11%)

Query: 258  EGGTENDLRILEQEEEEEQAGKPGEPSK-KEEGRAGAGLGD-----GERKTNDKDEKKED 311
            EG  E +    E+EE E +  + GE  + +EEG  G G G+     GE +   + E +E+
Sbjct: 839  EGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEE 898

Query: 312  GKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKK------------SSKKRNRKHSGD 359
              + E +   + + ++ EG+G  EE+ E+ E E ++              ++   +  G+
Sbjct: 899  EGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGE 958

Query: 360  DSFDEG-SVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEK 402
            +   EG    E E E E G+ E E+EE E   E+E+ +EE  E+
Sbjct: 959  EEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEE 1002



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 39/143 (27%), Positives = 68/143 (47%), Gaps = 10/143 (6%)

Query: 270  QEEEEEQAGKPGEPSKKEEGRAGAGLGDGER------KTNDKDEKKEDGKQAENDSSNDD 323
            +EE EE  G+  E   + EG  G G G+ E       +   + E +E+G+    +   + 
Sbjct: 922  EEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEG 981

Query: 324  KTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVS----ESESESESGQA 379
            + ++ EG+G++EE +E+ E+E +   +        ++   EG V     E E E E G+ 
Sbjct: 982  EEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEE 1041

Query: 380  EEEKEEAEALKEKEKPKEEEWEK 402
            E E+ E E   E+ +   EE E+
Sbjct: 1042 EGEEREKEGEGEENRRNREEEEE 1064



 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 55/239 (23%), Positives = 101/239 (42%), Gaps = 5/239 (2%)

Query: 165 ETEAVKRYNDYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNRLRVF 224
           E E  ++    K D   Q+ ++    H+ E     +   +E     +E  G  +      
Sbjct: 693 EKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKE 752

Query: 225 LSLMETGWFDNLLLDIDKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPS 284
               E G  + +  + +K +   K  + A  + +G  E D    E+EE E +  +  E  
Sbjct: 753 GEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGG 812

Query: 285 KKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSE-K 343
           + E G    G G+ E +  + + ++E+G+  E +   +++    EG+G  EE+ E+ E +
Sbjct: 813 EVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEE----EGEGKGEEEGEEGEGE 868

Query: 344 EAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEK 402
           E  +  +    +  G+   +E    E E E   G+ EEE E     +E E   EEE E+
Sbjct: 869 EEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEE 927



 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 40/141 (28%), Positives = 71/141 (50%), Gaps = 9/141 (6%)

Query: 258  EGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAEN 317
            EG  E +    E EEEE +    GE  ++ EG    G G+GE +  + + ++E+G++   
Sbjct: 945  EGEGEEEEGEWEGEEEEGE----GEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGE 1000

Query: 318  DSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESG 377
            +    ++    EG+G+ EE+ E+ E E +   ++   +   ++  +EG   E E E E  
Sbjct: 1001 EEGEGEE----EGEGEGEEE-EEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEEN 1055

Query: 378  QAEEEKEEAEALKEKEKPKEE 398
            +   E+EE E  K +E  +EE
Sbjct: 1056 RRNREEEEEEEGKYQETGEEE 1076



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 36/139 (25%), Positives = 71/139 (51%), Gaps = 6/139 (4%)

Query: 270  QEEEEEQAGKPGEPSKKEE-----GRAGAGLGDGERKTNDKDEKKE-DGKQAENDSSNDD 323
            +EEE E  G+ GE   +EE     G    G G+GE +   + E+ E +G++ E +   ++
Sbjct: 933  EEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEE 992

Query: 324  KTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEK 383
            +  + EG+ + E ++E   +  ++   +   +  G++   EG   E E E E  + E E 
Sbjct: 993  EEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEG 1052

Query: 384  EEAEALKEKEKPKEEEWEK 402
            EE    +E+E+ +E ++++
Sbjct: 1053 EENRRNREEEEEEEGKYQE 1071



 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 43/184 (23%), Positives = 88/184 (47%), Gaps = 20/184 (10%)

Query: 242 KADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGL-GDGER 300
           KA ++ +  D    + +G  E      E  ++EE+     E  +K++GR      G+GE+
Sbjct: 640 KAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEER-----EKGEKDKGRGEMERPGEGEK 694

Query: 301 KTNDKDE------------KKEDGKQAENDSSNDDKTKKSEGDGDKEE--KKEDSEKEAK 346
           +  +K+E            ++E G Q E +   ++  ++  G+G++EE  ++E+ EKE +
Sbjct: 695 ELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGE 754

Query: 347 KSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDA 406
              +    +  G+   +EG   + E   +  + EEE ++ E  +E+ + + EE E+  + 
Sbjct: 755 GKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEV 814

Query: 407 AGLE 410
            G E
Sbjct: 815 EGGE 818



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 32/135 (23%), Positives = 68/135 (50%), Gaps = 8/135 (5%)

Query: 269  EQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTK-- 326
            E EEEEE     GE   + EG  G G G+ E    + +E++++G+  EN  + +++ +  
Sbjct: 1012 EGEEEEE-----GEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEE 1066

Query: 327  -KSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEE 385
             K +  G++E +++D E+  K S  K + K+    ++ + SV+ ++   +  +++   + 
Sbjct: 1067 GKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQRSKMPVQS 1126

Query: 386  AEALKEKEKPKEEEW 400
               LK      ++ W
Sbjct: 1127 KRLLKNGPSGSKKFW 1141



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 42/139 (30%), Positives = 68/139 (48%), Gaps = 17/139 (12%)

Query: 283 PSKKE--EGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKED 340
           P +KE  E   G G+ + E + N+++ K   G++ + +  +DD T K+E      E K  
Sbjct: 587 PEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAE----VSEGKAK 642

Query: 341 SEKEAKKSSKKRNRKHSGDDSFDEGSVSE---SESESESGQAEEEKEEAE--ALKEKEKP 395
           S  EA+   + R     GD + +EGS       + E E G+ ++ + E E     EKE  
Sbjct: 643 SVGEAEDGPEGR-----GDGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELA 697

Query: 396 KEEEWEKPKDAAGLECKPR 414
           ++EEW+K +D    E K R
Sbjct: 698 EKEEWKK-RDGEEQEQKER 715


>gi|4759128 solute carrier family 24 (sodium/potassium/calcium
           exchanger), member 1 [Homo sapiens]
          Length = 1099

 Score = 66.2 bits (160), Expect = 1e-10
 Identities = 48/152 (31%), Positives = 73/152 (48%), Gaps = 14/152 (9%)

Query: 259 GGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAG-----LGDGERKTNDKDEKKEDGK 313
           GG E+   + E E   E  G+ GE + + E    +G      G+GE +T  K E+ ED  
Sbjct: 742 GGQED---VAEAESTGEMPGEEGETAGEGETEEKSGGETQPEGEGETETQGKGEECEDEN 798

Query: 314 QAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSS------KKRNRKHSGDDSFDEGSV 367
           +AE    N+ + +      D E K  + E E+++ S       K + K   D    +G  
Sbjct: 799 EAEGKGDNEGEDEGEIHAEDGEMKGNEGETESQELSAENHGEAKNDEKGVEDGGGSDGGD 858

Query: 368 SESESESESGQAEEEKEEAEALKEKEKPKEEE 399
           SE E E E  Q EEE+EE +  +E+E+ +EEE
Sbjct: 859 SEEEEEEEEEQEEEEEEEEQEEEEEEEEEEEE 890


>gi|239508778 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 123

 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 34/108 (31%), Positives = 60/108 (55%), Gaps = 2/108 (1%)

Query: 299 ERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSG 358
           +++T + +E +E  ++ E +    +K K+   + +K++K +++EK  +K  +++ RK   
Sbjct: 7   KKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKR 66

Query: 359 DDSFDEGSVSESESESESGQAEEEKEEAEALKEKEK--PKEEEWEKPK 404
               +E    E E E E  + EEEKEE    K+K+K   KEEE EK K
Sbjct: 67  KKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKK 114



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 24/93 (25%), Positives = 51/93 (54%), Gaps = 1/93 (1%)

Query: 313 KQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESES 372
           K+ +      ++T+++E + ++EE+KE   KE +K  +K   K       ++    E E 
Sbjct: 1   KKKKKKKKETEETEETE-ETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEE 59

Query: 373 ESESGQAEEEKEEAEALKEKEKPKEEEWEKPKD 405
           +    + +++KEE E  +E+E+ +EE+ E+ K+
Sbjct: 60  KKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKE 92



 Score = 34.3 bits (77), Expect = 0.52
 Identities = 24/70 (34%), Positives = 36/70 (51%), Gaps = 4/70 (5%)

Query: 350 KKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKE-EEWEKPKDAAG 408
           KK+ +K    +  +E   +E E E E  + E+ KE+    KEKEK K+ +E EK K+   
Sbjct: 1   KKKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKR---KEKEKKKKTKETEKRKEKEE 57

Query: 409 LECKPRPLHK 418
            E K +   K
Sbjct: 58  EEKKRKRKRK 67



 Score = 31.2 bits (69), Expect = 4.4
 Identities = 14/66 (21%), Positives = 33/66 (50%)

Query: 17  RRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDRNRRERFSPPRHELSPP 76
           R+E+ + ++ R+R  +++ ++    E +   E     E ++  R R+++    R E    
Sbjct: 52  RKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEE 111

Query: 77  QKRMRR 82
           +K+ RR
Sbjct: 112 KKKKRR 117


>gi|210032580 SET domain containing 1B [Homo sapiens]
          Length = 1923

 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 44/155 (28%), Positives = 79/155 (50%), Gaps = 15/155 (9%)

Query: 259  GGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAEND 318
            GG E++   L +E+E  +  +  E  ++EE        D +  ++D+DE + D    + D
Sbjct: 1032 GGEEDEKESLSEEQESTEEEEEAEEEEEEED-------DDDDDSDDRDESEND----DED 1080

Query: 319  SSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESE--S 376
            ++  + ++K EGD D+EE       +A+ +S   + + S  +S  E S S SE E E  +
Sbjct: 1081 TALSEASEKDEGDSDEEETVSIVTSKAEATSSSESSESSEFESSSESSPSSSEDEEEVVA 1140

Query: 377  GQAEEEKEEAEALKEKEKPK--EEEWEKPKDAAGL 409
             + EEE+EE E + E+       E++E+  + A L
Sbjct: 1141 REEEEEEEEEEMVAEESMASAGPEDFEQDGEEAAL 1175



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 34/156 (21%), Positives = 69/156 (44%), Gaps = 25/156 (16%)

Query: 269  EQEEEEEQAGKPGEPSKKEEGRAGAGLG-------DGERKTNDKDEKKEDGKQAENDSSN 321
            E+E + + A  P E +K++    G           D   + ++K+   E+ +  E +   
Sbjct: 995  ERERDRDMADTPCELAKRDPKGVGVRRRPARPLELDSGGEEDEKESLSEEQESTEEEEEA 1054

Query: 322  DDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSV-------------- 367
            +++ ++ + D D  + +++SE + + ++     +    DS +E +V              
Sbjct: 1055 EEEEEEEDDDDDDSDDRDESENDDEDTALSEASEKDEGDSDEEETVSIVTSKAEATSSSE 1114

Query: 368  ----SESESESESGQAEEEKEEAEALKEKEKPKEEE 399
                SE ES SES  +  E EE    +E+E+ +EEE
Sbjct: 1115 SSESSEFESSSESSPSSSEDEEEVVAREEEEEEEEE 1150



 Score = 38.5 bits (88), Expect = 0.027
 Identities = 36/125 (28%), Positives = 57/125 (45%), Gaps = 14/125 (11%)

Query: 289  GRAGAGLGDGERKT----NDKDEKKE--------DGKQAENDSSNDDKTKKSEGDGDKEE 336
            G  G GLG G R      + K ++KE        D K+    +S D++ ++SE + D++ 
Sbjct: 943  GYEGLGLGIGLRGAIRLPSFKVKRKEPPDTTSSGDQKRLRPSTSVDEEDEESERERDRDM 1002

Query: 337  KKEDSE--KEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEALKEKEK 394
                 E  K   K    R R     +    G   E ES SE  ++ EE+EEAE  +E+E 
Sbjct: 1003 ADTPCELAKRDPKGVGVRRRPARPLELDSGGEEDEKESLSEEQESTEEEEEAEEEEEEED 1062

Query: 395  PKEEE 399
              +++
Sbjct: 1063 DDDDD 1067



 Score = 33.9 bits (76), Expect = 0.68
 Identities = 23/68 (33%), Positives = 27/68 (39%), Gaps = 5/68 (7%)

Query: 759 PALPEIKPAQPPGPAQILPPG--LTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAV 816
           P  P + P  PP P Q   PG  + P LP P   P    P     PP L    G   P +
Sbjct: 685 PGFPPLPPPPPPPPPQ---PGFPMPPPLPPPPPPPPPAHPAVTVPPPPLPAPPGVPPPPI 741

Query: 817 PTGGPPYP 824
               PP+P
Sbjct: 742 LPPLPPFP 749



 Score = 32.7 bits (73), Expect = 1.5
 Identities = 24/69 (34%), Positives = 24/69 (34%), Gaps = 16/69 (23%)

Query: 759 PALPEIKPAQPPGPAQILPPGLTPGLPYPHQTPQGLMPYGQPRPPILGYGAGAVRPAVPT 818
           P  P   P  PP P    PP   PG P P   P    P   P PP          PAV  
Sbjct: 682 PPPPGFPPLPPPPP----PPPPQPGFPMPPPLP----PPPPPPPP--------AHPAVTV 725

Query: 819 GGPPYPHAP 827
             PP P  P
Sbjct: 726 PPPPLPAPP 734



 Score = 31.2 bits (69), Expect = 4.4
 Identities = 25/81 (30%), Positives = 32/81 (39%), Gaps = 9/81 (11%)

Query: 753 LTDAKRPALPEIKPAQP------PGPAQILPPG-LTPGLPYPHQTPQGLMPYGQPRPPIL 805
           ++D + P+ P      P      PG A +  P  L P LP P   P G  P   P PP  
Sbjct: 641 ISDDEMPSAPITSADCPKPMVVTPGAAAVAAPSVLAPTLPLP--PPPGFPPLPPPPPPPP 698

Query: 806 GYGAGAVRPAVPTGGPPYPHA 826
                 + P +P   PP P A
Sbjct: 699 PQPGFPMPPPLPPPPPPPPPA 719



 Score = 30.4 bits (67), Expect = 7.5
 Identities = 25/81 (30%), Positives = 30/81 (37%), Gaps = 11/81 (13%)

Query: 755  DAKRPALPEIKPAQP----PGPAQILPPGLTPGLPYPHQTPQGLMPYGQPRPPILGYGAG 810
            +A+ P  PE  P       P P  +LP  L P LP P        P   P PP       
Sbjct: 1249 EARPPLSPERAPEHDLEVEPEPPMMLPLPLQPPLPPPR-------PPRPPSPPPEPETTD 1301

Query: 811  AVRPAVPTGGPPYPHAPYGAG 831
            A  P+VP       H P+  G
Sbjct: 1302 ASHPSVPPEPLAEDHPPHTPG 1322


>gi|221219020 NYD-SP11 protein [Homo sapiens]
          Length = 2873

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 32/104 (30%), Positives = 65/104 (62%), Gaps = 1/104 (0%)

Query: 302  TNDKDEKKEDGKQAENDSSNDDKTKKSEGDGD-KEEKKEDSEKEAKKSSKKRNRKHSGDD 360
            + +++E++E+ ++ E +   +++ +K E +G+ K+ +KE+ EK+ KK  KK+      ++
Sbjct: 2245 SEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEE 2304

Query: 361  SFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPK 404
             F+E     SE E+ES   EEE+EE+ +L+E+   ++E  +K K
Sbjct: 2305 VFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDREKEILKKEK 2348



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 40/149 (26%), Positives = 74/149 (49%), Gaps = 10/149 (6%)

Query: 267  ILEQEEE---EEQAGKPGEPSK-KEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSND 322
            IL+ EEE   EE+   P    + ++   A  G    E+ ++  DE + +   +E   S  
Sbjct: 2175 ILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLL 2234

Query: 323  DKTKK-----SEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESG 377
            D+ +K     SE + ++EE++E  E+E ++  ++R  +  G++   E    E + + +  
Sbjct: 2235 DELEKQESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEK 2294

Query: 378  QAEEEKEEAEALKEKEK-PKEEEWEKPKD 405
            + EE +E+ E  +EKE+   EEE E   D
Sbjct: 2295 KKEEVQEKEEVFEEKEEIMSEEETESLSD 2323



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 40/145 (27%), Positives = 67/145 (46%), Gaps = 22/145 (15%)

Query: 285  KKEEGRAGAGLGDGERKTNDKDEK--KEDGKQAENDSSN--DDKTKKSEGDGDKEE---- 336
            +K+  R    L +  R+  +K+EK  +E+ K A   S    DD+    EG  ++EE    
Sbjct: 2136 EKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDE---EEGGIEEEEVIPF 2192

Query: 337  --KKEDSEKEAKKSSKKRNRKHSGDDSFD---------EGSVSESESESESGQAEEEKEE 385
              ++    KEAK+  K + +  S  D  +         E  + E E +      EEE+ E
Sbjct: 2193 LKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEERE 2252

Query: 386  AEALKEKEKPKEEEWEKPKDAAGLE 410
             E  +E+E+ +EEE E+ ++  G E
Sbjct: 2253 EEEEREEEEVREEEEERKEEEEGEE 2277



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 102/512 (19%), Positives = 202/512 (39%), Gaps = 69/512 (13%)

Query: 262  ENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQA-ENDSS 320
            E + R+L++EE+  QAG+   P +             E    DK  K E+ KQ  EN  S
Sbjct: 1484 EWEKRLLQEEEKLHQAGEKLSPEE-------------EMLQEDKKLKWEEWKQVWENMLS 1530

Query: 321  NDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAE 380
            +  K ++ + + +   ++E S +  +K  +    +    +      +    + +E  +A+
Sbjct: 1531 SKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHKWARIHRKRARAEKKRAQ 1590

Query: 381  EEK---EEAEALKEKEKPKEEEWEKPKDA-AGLECKPRPLHKTCSLFMRNIAPNISRAEI 436
            EE+   +E E L ++E+   +E  K   A   +    R + +    F +       R E 
Sbjct: 1591 EERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQAEGKFAQKEETLAQRGEK 1650

Query: 437  IS------------LCKRYPGFMRVALSEPQPERRFFRRGWVTFDRSVNIKEICWNLQNI 484
            +S            L K++    +VA  E +  ++  +   V    +  ++E+    QN+
Sbjct: 1651 LSQEAEKLAQKRKKLAKKWE---KVAREEEKLAKKGGKLAEVKNILAQKVEELPQREQNL 1707

Query: 485  RLRECELSPGVN------RDLTRRVRNINGITQHKQIVRNDIKLAAKLIHTLDDRTQLWA 538
              +E EL+  +        +L+ +   +N   +  ++V    KLA       ++    W 
Sbjct: 1708 DWQEKELAQELEELEWDMEELSWKEEELN--QEEGKLVEEKKKLAE------EEEALAWQ 1759

Query: 539  SEPGTPPLPTSLPSQNPILKNITDYLIE--EVSAEEEELLGSSGGAPPEEPPKEGNPAEI 596
             E  +    T L  +  +L    + L +  E   EEEE LG       E+  K     E 
Sbjct: 1760 REKLSEE-ETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRER 1818

Query: 597  NVERDEKLIKVLDKLLLYLRIVHSLDYYNTCE------YPNEDEMPNRCGIIHVRGPMPP 650
             +   E+L K  +K++LY +   + +  N  +         E+ + N+  + H +  +  
Sbjct: 1819 WINSMEELTK--NKMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQ 1876

Query: 651  NRISHGEVLEWQKTFEEKLT----PLLSVRESLSEEEAQKMGRKDPEQEVEKFVTSNTQE 706
             +   G   +     EEKLT     ++  +E L+E E + +       +VE  +    ++
Sbjct: 1877 VKNKLGMFNKILAQVEEKLTQEKETVIKKKEKLAETEKKLV-------QVEDSLAKKQEK 1929

Query: 707  LGKDKWLCPLSGKKFKGPEFVRKHIFNKHAEK 738
            L ++K    L     +G + +R  +     EK
Sbjct: 1930 LAQEKMKLALEKAMVQGKKRLRGELDIAKEEK 1961



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 41/177 (23%), Positives = 77/177 (43%), Gaps = 43/177 (24%)

Query: 234  DNLLLDIDKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGA 293
            ++LL +++K +++    +    + E   E ++R   +EEEE +  + GE  + E+     
Sbjct: 2231 ESLLDELEKQESLSSEEEEEREEEEEREEEEVR---EEEEERKEEEEGEEKQVEK----- 2282

Query: 294  GLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRN 353
               + E+K   K++KKE+ ++            K E   +KEE   + E E         
Sbjct: 2283 --EEEEKKKKKKEKKKEEVQE------------KEEVFEEKEEIMSEEETE--------- 2319

Query: 354  RKHSGDDSFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLE 410
                        S+S+ E E ES   EEE +  + + +KEK  + + ++ K   G E
Sbjct: 2320 ------------SLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRKSLRGRE 2364



 Score = 35.8 bits (81), Expect = 0.18
 Identities = 25/97 (25%), Positives = 45/97 (46%), Gaps = 2/97 (2%)

Query: 324  KTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSG--DDSFDEGSVSESESESESGQAEE 381
            + +K    GDK ++K  S+ +  +S +  + +     D+   + S+S  E E    + E 
Sbjct: 2198 RKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEER 2257

Query: 382  EKEEAEALKEKEKPKEEEWEKPKDAAGLECKPRPLHK 418
            E+EE    +E+ K +EE  EK  +    E K +   K
Sbjct: 2258 EEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEK 2294



 Score = 31.2 bits (69), Expect = 4.4
 Identities = 39/154 (25%), Positives = 69/154 (44%), Gaps = 22/154 (14%)

Query: 257  MEGGTENDLRILE-QEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQA 315
            ++G T+  +R  E    EEEQA K          +A   LG  E +   K  KK    + 
Sbjct: 1329 IQGVTQEVIRHKEVMPREEEQAQK----------KARDMLGLEETQVILKKGKKVIFLEP 1378

Query: 316  ENDSSNDDKTKKSEGDGDKEEKK--EDSEKEAKKSSKKRNR--KHSGDDSFDEGSVSESE 371
             N +   + +KK       EEKK  + S K+ +K+ +K  +  K   + + +E  +SE  
Sbjct: 1379 GNVTMGKEISKK-------EEKKTFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEV 1431

Query: 372  SESESGQAEEEKEEAEALKEKEKPKEEEWEKPKD 405
             E  + + +  K+E + +  +  P  ++W+K  D
Sbjct: 1432 EEMATLEEKVVKQEGKLVMIERTPSWQDWKKAWD 1465



 Score = 30.0 bits (66), Expect = 9.8
 Identities = 19/85 (22%), Positives = 43/85 (50%)

Query: 270  QEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSE 329
            ++EEEE+  K  E  K+E         + E   ++++ +    ++ E +S + ++    E
Sbjct: 2281 EKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCSLEEEVDRE 2340

Query: 330  GDGDKEEKKEDSEKEAKKSSKKRNR 354
             +  K+EK+   +++ +KS + R R
Sbjct: 2341 KEILKKEKQFKLQEQRRKSLRGRER 2365


>gi|32484979 adaptor-related protein complex 3, beta 1 subunit [Homo
           sapiens]
          Length = 1094

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 44/150 (29%), Positives = 72/150 (48%), Gaps = 8/150 (5%)

Query: 266 RILEQEEEEEQAGKPGEPSKKEEGRAGAGLGD-GERKTNDKDEKKEDGKQAENDSSNDD- 323
           +   + EEEE +      S+ E G      G+ GE   +++D  ++   + +++S  +  
Sbjct: 674 KFYSESEEEEDSSDSSSDSESESGSESGEQGESGEEGDSNEDSSEDSSSEQDSESGRESG 733

Query: 324 -KTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFD-EGSVSESESESESGQAEE 381
            + K++     K + K DSE   K++ K +    S D+S   E S S+SESESE    E 
Sbjct: 734 LENKRTAKRNSKAKGKSDSEDGEKENEKSKTSDSSNDESSSIEDSSSDSESESE---PES 790

Query: 382 EKEEAEALKEKE-KPKEEEWEKPKDAAGLE 410
           E E     KEKE K K++     KD + L+
Sbjct: 791 ESESRRVTKEKEKKTKQDRTPLTKDVSLLD 820



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 27/96 (28%), Positives = 44/96 (45%), Gaps = 4/96 (4%)

Query: 314 QAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRK-HSGDDSFDEGSVSESES 372
           +A+ ++S      +SE + D  +   DSE E+   S ++      GD + D    S SE 
Sbjct: 665 KAKQENSAKKFYSESEEEEDSSDSSSDSESESGSESGEQGESGEEGDSNEDSSEDSSSEQ 724

Query: 373 ESESGQ---AEEEKEEAEALKEKEKPKEEEWEKPKD 405
           +SESG+    E ++      K K K   E+ EK  +
Sbjct: 725 DSESGRESGLENKRTAKRNSKAKGKSDSEDGEKENE 760



 Score = 38.1 bits (87), Expect = 0.036
 Identities = 25/80 (31%), Positives = 37/80 (46%), Gaps = 1/80 (1%)

Query: 334 KEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEALKEKE 393
           KE       K+   + K  +     +DS D  S SESES SESG+  E  EE ++ ++  
Sbjct: 658 KEWTPAGKAKQENSAKKFYSESEEEEDSSDSSSDSESESGSESGEQGESGEEGDSNEDSS 717

Query: 394 KPKEEEWEKPKD-AAGLECK 412
           +    E +      +GLE K
Sbjct: 718 EDSSSEQDSESGRESGLENK 737


>gi|69354671 ATP-binding cassette, sub-family F, member 1 isoform a
           [Homo sapiens]
          Length = 845

 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 65/267 (24%), Positives = 119/267 (44%), Gaps = 32/267 (11%)

Query: 148 VMKTFKEFLLSLDDSVDETEAVKRYNDYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVG 207
           + KTF E L   D    E E V +  + +   ++QQ +      +D    R K   D+ G
Sbjct: 37  IKKTFFEELAVEDKQAGEEEKVLKEKEQQQQQQQQQQKK----KRDTRKGRRKKDVDDDG 92

Query: 208 KRRQEARGALQNRLRVFLSLMETGWFDNLLLDIDKADAIVKMLDAAVIKMEGGTENDLRI 267
           + ++     L  RL+  LS+  +          D+ D +         K +GG      I
Sbjct: 93  EEKE-----LMERLKK-LSVPTS----------DEEDEVPAPKPRGGKKTKGGNVFAALI 136

Query: 268 LEQ-EEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTK 326
            +Q EEEEE+   P +P+K E+ R    + + ++       K + GK+ ++      + K
Sbjct: 137 QDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPA----LKGKKGKEEKSKGKAKPQNK 192

Query: 327 KSEGDGDKEEKKED--SEKEAKKSSKKRNRK-HSGDDSFDEGSVSESESESESGQAEEEK 383
            +  D ++E+K+E+   EKE  K  K++ +K   G +   EG     E E E G+++ + 
Sbjct: 193 FAALDNEEEDKEEEIIKEKEPPKQGKEKAKKAEQGSEEEGEG----EEEEEEGGESKADD 248

Query: 384 EEAEALKEKEKPKEEEWEKPKDAAGLE 410
             A   K+++K  +++ E  +  A L+
Sbjct: 249 PYAHLSKKEKKKLKKQMEYERQVASLK 275



 Score = 35.4 bits (80), Expect = 0.23
 Identities = 31/121 (25%), Positives = 52/121 (42%), Gaps = 11/121 (9%)

Query: 295 LGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNR 354
           +GDGE  T+  D+  + GK+       D K KK+  +    E K+  E+E     K++ +
Sbjct: 15  IGDGE-STSPSDKVVKKGKK-------DKKIKKTFFEELAVEDKQAGEEEKVLKEKEQQQ 66

Query: 355 KHSGDDSFDEGSVSESESESESGQAEEEKEEAEALKEKEKP---KEEEWEKPKDAAGLEC 411
           +        +    +   + +     EEKE  E LK+   P   +E+E   PK   G + 
Sbjct: 67  QQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAPKPRGGKKT 126

Query: 412 K 412
           K
Sbjct: 127 K 127



 Score = 32.3 bits (72), Expect = 2.0
 Identities = 28/132 (21%), Positives = 53/132 (40%), Gaps = 13/132 (9%)

Query: 296 GDGERKTNDKDEKKEDGKQAENDSSNDDK-TKKSEGDGDKEEKK------------EDSE 342
           G+ E+   +K+++++  +Q +    +  K  +K + D D EEK+             D E
Sbjct: 53  GEEEKVLKEKEQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEE 112

Query: 343 KEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEK 402
            E      +  +K  G + F      +SE E E  +   +  + E  +  +   EE+   
Sbjct: 113 DEVPAPKPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPAKPEKNRINKAVSEEQQPA 172

Query: 403 PKDAAGLECKPR 414
            K   G E K +
Sbjct: 173 LKGKKGKEEKSK 184



 Score = 32.0 bits (71), Expect = 2.6
 Identities = 34/156 (21%), Positives = 64/156 (41%), Gaps = 26/156 (16%)

Query: 269 EQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKS 328
           +Q  E E  G  GE +   +     G  D + K    +E   + KQA      ++K  K 
Sbjct: 7   QQPPEPEWIGD-GESTSPSDKVVKKGKKDKKIKKTFFEELAVEDKQA----GEEEKVLKE 61

Query: 329 EGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKE---- 384
           +   +++++++  +++ K+ ++K  RK   DD  +E  + E   +     ++EE E    
Sbjct: 62  K---EQQQQQQQQQQKKKRDTRKGRRKKDVDDDGEEKELMERLKKLSVPTSDEEDEVPAP 118

Query: 385 --------------EAEALKEKEKPKEEEWEKPKDA 406
                          A    + E+ +EEE   PK A
Sbjct: 119 KPRGGKKTKGGNVFAALIQDQSEEEEEEEKHPPKPA 154


>gi|55741677 SET domain containing 1A [Homo sapiens]
          Length = 1707

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 49/159 (30%), Positives = 73/159 (45%), Gaps = 15/159 (9%)

Query: 269  EQEEEEEQAGKPG-EPSKKEEGRAGAGLGDGE-RKTNDKDEKKEDGKQAENDSSNDDKTK 326
            EQE+E  + G+PG +P K++E R   G   G+ RK+   D + E+  Q  +   +++  +
Sbjct: 926  EQEKEAGEPGRPGTKPPKRDEER---GKTQGKHRKSFALDSEGEEASQESSSEKDEEDDE 982

Query: 327  KSEGDGDKEE-----KKE----DSEKEAKKSSKKRNRKHSGDDSFDEGSVSESE-SESES 376
            + E D D+EE     KKE    D E E   SS K +     D   D  S SES  S S S
Sbjct: 983  EDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSS 1042

Query: 377  GQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECKPRP 415
              +      + +    E   E+E E+ + AA     P P
Sbjct: 1043 SSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPPP 1081



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 37/165 (22%), Positives = 67/165 (40%), Gaps = 8/165 (4%)

Query: 279  KPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGK--QAENDSSNDDKTKKSEGDGDKEE 336
            K G  +  E    G+GL    R  + K ++KE  +  +A  +      T   E + D E+
Sbjct: 868  KSGGTTGIEAFAFGSGLRGALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQ 927

Query: 337  KKEDSE------KEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEALK 390
            +KE  E      K  K+  ++   +     SF   S  E  S+  S + +EE +E +   
Sbjct: 928  EKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEED 987

Query: 391  EKEKPKEEEWEKPKDAAGLECKPRPLHKTCSLFMRNIAPNISRAE 435
            E  +   +  +K  + +  E +       CSL+  +   N S ++
Sbjct: 988  EDREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSD 1032



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 57/241 (23%), Positives = 87/241 (36%), Gaps = 64/241 (26%)

Query: 190  AHKDEEWFRSKYHPDEVGK------RRQEARGALQNRLRVFLSLMETGWFDNLLLDIDKA 243
            A +DE+    +    E G+      +R E RG  Q + R   +L   G         ++A
Sbjct: 918  AEEDEDDPEQEKEAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEG---------EEA 968

Query: 244  DAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTN 303
                   +++  K E   E D    ++EE  +                          T 
Sbjct: 969  SQ-----ESSSEKDEEDDEEDEEDEDREEAVD--------------------------TT 997

Query: 304  DKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFD 363
             K+ +  DG+  E+DSS+   +  ++ DG+      DS  +++ SS   +   S   S  
Sbjct: 998  KKETEVSDGEDEESDSSS-KCSLYADSDGE-----NDSTSDSESSSSSSSSSSSSSSSSS 1051

Query: 364  EGSVSESESESESGQAEEEKEEAEALKEKEKPKEE---------EWEKPKDAAGLECKPR 414
              S S SES SE    EEE+E   AL     P  E         E   P+  AG    P 
Sbjct: 1052 SSSSSSSESSSED---EEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPL 1108

Query: 415  P 415
            P
Sbjct: 1109 P 1109



 Score = 32.7 bits (73), Expect = 1.5
 Identities = 25/69 (36%), Positives = 27/69 (39%), Gaps = 13/69 (18%)

Query: 759 PALPEIKPAQPPGPAQILPPGLTPGLP--YPHQTPQGLMPYGQPRPPILGYGAGAVRPAV 816
           P  P+  P  PP P    PP     LP  YP   P  L+P   PRP       G   P  
Sbjct: 598 PTPPQQPPPPPPPPPP--PPPYLASLPLGYPPHQPAYLLP---PRPD------GPPPPEY 646

Query: 817 PTGGPPYPH 825
           P   PP PH
Sbjct: 647 PPPPPPPPH 655


>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 245

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 45/177 (25%), Positives = 79/177 (44%), Gaps = 23/177 (12%)

Query: 260 GTENDLRILEQEEEEEQAGKPGEPSKKEEGR-----------------AGAGLGDGERKT 302
           G ++++R  E+E E  + GK    S++++ R                  G     GERK 
Sbjct: 33  GWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKK 92

Query: 303 NDKDEKK----EDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKK-RNRKHS 357
            +++ KK    ++ K+ E       K KK  G   KE K+ + ++E K+  +K R RK  
Sbjct: 93  EERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKE 152

Query: 358 GDDSFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECKPR 414
             +   E    +     + G+ EEE++E E  KE++K +    E+ K+    E + R
Sbjct: 153 EREKERERKERKKRERKQVGEKEEERKEKER-KERKKRERNRKERKKERERKERRER 208



 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 40/150 (26%), Positives = 71/150 (47%), Gaps = 13/150 (8%)

Query: 269 EQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKS 328
           E++ E  +  K GE  K+E  R         ++  +K+++K+  K+    +S + K ++ 
Sbjct: 76  ERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERER 135

Query: 329 EGDGDKEEKKE------DSEKE-AKKSSKKRNRKHSGDDSFDEGSVSESE------SESE 375
           + +  +EE+KE      + EKE  +K  KKR RK  G+   +       E      +  E
Sbjct: 136 KEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKE 195

Query: 376 SGQAEEEKEEAEALKEKEKPKEEEWEKPKD 405
             +  E KE  E  KE++K +E + E+ KD
Sbjct: 196 RKKERERKERRERKKERKKKEERKKERQKD 225



 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 35/153 (22%), Positives = 76/153 (49%), Gaps = 3/153 (1%)

Query: 262 ENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSN 321
           E + +   +E+E ++  +  +  KKE+   G    +G+ +   ++ K+E+ K+ E     
Sbjct: 94  ERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEE 153

Query: 322 DDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEE 381
            +K ++ + +  K E+K+  EKE ++  K+R  +   + +  E    E E +    + +E
Sbjct: 154 REKERERK-ERKKRERKQVGEKEEERKEKERKERKKRERNRKERK-KERERKERRERKKE 211

Query: 382 EKEEAEALKEKEKPKEEEWEKPKDAAGLECKPR 414
            K++ E  KE++K ++  W + K+    E K R
Sbjct: 212 RKKKEERKKERQKDRQTNW-REKERGKRERKER 243



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 35/142 (24%), Positives = 64/142 (45%), Gaps = 6/142 (4%)

Query: 269 EQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDE------KKEDGKQAENDSSND 322
           ++ +E E+  K  +  KKE GR      + ERK   K E      +K++ ++ E +    
Sbjct: 104 KENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKER 163

Query: 323 DKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEE 382
            K ++ +    +EE+KE   KE KK  + R  +    +  +     +   + E  + E +
Sbjct: 164 KKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQ 223

Query: 383 KEEAEALKEKEKPKEEEWEKPK 404
           K+     +EKE+ K E  E+ K
Sbjct: 224 KDRQTNWREKERGKRERKERKK 245



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 27/92 (29%), Positives = 46/92 (50%), Gaps = 3/92 (3%)

Query: 310 EDGKQAENDSSNDDKTKKSEGDGDK--EEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSV 367
           + G Q+E      +   + EG  ++  E KKE  E+E +K  +++ RK        +G  
Sbjct: 31  QPGWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGER 90

Query: 368 SESESESESGQAEEEKEEAEALKEKEKPKEEE 399
            + E E +  + E+E +E E  KEK K KE++
Sbjct: 91  KKEERERKKRRREKENKEGEE-KEKRKKKEKK 121



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 21/85 (24%), Positives = 43/85 (50%)

Query: 6   DEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDRNRRER 65
           +E  R  R +  R++ + ++ RER ER++ +     E +  R+ + R E +  +RNR+ER
Sbjct: 137 EERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKER 196

Query: 66  FSPPRHELSPPQKRMRRDWDEHSSD 90
                 +    +K+ R+  +E   +
Sbjct: 197 KKERERKERRERKKERKKKEERKKE 221



 Score = 37.4 bits (85), Expect = 0.061
 Identities = 20/77 (25%), Positives = 41/77 (53%), Gaps = 5/77 (6%)

Query: 7   EYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDRNRRERF 66
           E  +RRR+K  +E  + ++ ++++++ RG     R    G+ER  + E +  +R  RER 
Sbjct: 96  ERKKRRREKENKEGEEKEKRKKKEKKERG-----RTSKEGKERERKEERKREERKERERK 150

Query: 67  SPPRHELSPPQKRMRRD 83
              R +    ++R +R+
Sbjct: 151 KEEREKERERKERKKRE 167



 Score = 37.4 bits (85), Expect = 0.061
 Identities = 20/61 (32%), Positives = 34/61 (55%), Gaps = 2/61 (3%)

Query: 7   EYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRS--RGEYRDYDRNRRE 64
           E +R+ R K  R R +  + RER ERR       ++ +R +ER+   +  +R+ +R +RE
Sbjct: 180 EKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKERGKRE 239

Query: 65  R 65
           R
Sbjct: 240 R 240



 Score = 36.6 bits (83), Expect = 0.10
 Identities = 21/102 (20%), Positives = 52/102 (50%), Gaps = 2/102 (1%)

Query: 256 KMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQA 315
           + E   + + R  E+E +E +  +  +  +KEE R      + +++  ++ E+K++ ++ 
Sbjct: 144 RKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERK 203

Query: 316 ENDSSNDDKTKKSEGDGDKEEKKEDS--EKEAKKSSKKRNRK 355
           E      ++ KK E   ++++ ++ +  EKE  K  +K  +K
Sbjct: 204 ERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245



 Score = 35.4 bits (80), Expect = 0.23
 Identities = 17/63 (26%), Positives = 37/63 (58%), Gaps = 1/63 (1%)

Query: 3   DSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDRNR 62
           +S+ + +RR R+K +RER + +R RER ++ +  +    E +R + RR +      ++ +
Sbjct: 56  ESERKKERREREKRKRER-EKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEK 114

Query: 63  RER 65
           R++
Sbjct: 115 RKK 117



 Score = 33.9 bits (76), Expect = 0.68
 Identities = 21/66 (31%), Positives = 35/66 (53%), Gaps = 8/66 (12%)

Query: 3   DSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRER---RSRGEYRDYD 59
           + + E + R+  K  RE       RER++R+R     +RE +R RER     +GE +  +
Sbjct: 40  EREREIETRKEGKKERESERKKERREREKRKR-----EREKERKRERGKKEKKGERKKEE 94

Query: 60  RNRRER 65
           R R++R
Sbjct: 95  RERKKR 100



 Score = 32.3 bits (72), Expect = 2.0
 Identities = 20/79 (25%), Positives = 41/79 (51%), Gaps = 5/79 (6%)

Query: 3   DSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDRNR 62
           + + E   +R+ K ++ER     S+E  ER R +   +R+ +  +ER  + E R+ +R R
Sbjct: 106 NKEGEEKEKRKKKEKKERG--RTSKEGKERERKE---ERKREERKERERKKEEREKERER 160

Query: 63  RERFSPPRHELSPPQKRMR 81
           +ER    R ++   ++  +
Sbjct: 161 KERKKRERKQVGEKEEERK 179



 Score = 32.0 bits (71), Expect = 2.6
 Identities = 22/85 (25%), Positives = 41/85 (48%), Gaps = 7/85 (8%)

Query: 7   EYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGE-----YRDYDRN 61
           E  R  ++   RER +  +  ER ER R  +  +RE +R R+ R + E      ++ +R 
Sbjct: 122 ERGRTSKEGKERERKEERKREERKERERKKE--EREKERERKERKKRERKQVGEKEEERK 179

Query: 62  RRERFSPPRHELSPPQKRMRRDWDE 86
            +ER    + E +  +++  R+  E
Sbjct: 180 EKERKERKKRERNRKERKKERERKE 204



 Score = 31.6 bits (70), Expect = 3.4
 Identities = 19/62 (30%), Positives = 31/62 (50%), Gaps = 6/62 (9%)

Query: 25 RSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDRNRRERFSPPRHELSPPQKRMRRDW 84
          R RER+   R +   +RE +R +ERR R      ++ +RER    + E    +K+  R  
Sbjct: 39 REREREIETRKEGKKERESERKKERRER------EKRKREREKERKRERGKKEKKGERKK 92

Query: 85 DE 86
          +E
Sbjct: 93 EE 94


>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 275

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 47/181 (25%), Positives = 83/181 (45%), Gaps = 7/181 (3%)

Query: 256 KMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQA 315
           K E G E + +  E+E++ ++  +     +K+E +       G R+   K E+KE  ++ 
Sbjct: 68  KRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKE--RER 125

Query: 316 ENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESE 375
           EN    + K KK      ++E+K + E+  K+  K++ RK    +   E +  E + E E
Sbjct: 126 ENKQRRERKRKKRRKKKRRKERKREKER-GKRERKRKKRKKEEREKKRERNRKERKKERE 184

Query: 376 SGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECKPRPLHKTCSLFMRNIAPNISRAE 435
             +  E K+E +  KE+ K KE + ++  D        RPL +  S F R     + R  
Sbjct: 185 RKERRERKKERK--KERRKKKERKKDRKTDRQTDSQVFRPLRE--SAFNRVTVTGVFRYR 240

Query: 436 I 436
           I
Sbjct: 241 I 241



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 30/136 (22%), Positives = 63/136 (46%), Gaps = 3/136 (2%)

Query: 269 EQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKS 328
           +++ ++ + GK  E  +KE  +      + ER+   K++KK + KQ       + K KK 
Sbjct: 63  KKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQR---GRRERKKKKE 119

Query: 329 EGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEA 388
             + ++E K+    K  K+  KKR ++   +    +      + + E  + + E+   E 
Sbjct: 120 RKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKER 179

Query: 389 LKEKEKPKEEEWEKPK 404
            KE+E+ +  E +K +
Sbjct: 180 KKERERKERRERKKER 195



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 31/145 (21%), Positives = 71/145 (48%), Gaps = 9/145 (6%)

Query: 269 EQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKS 328
           ++E E+E+  + G+  KK+  +   G  + ERK  ++++++++ ++ E      +K K+ 
Sbjct: 47  KREREKERKRERGKKEKKKRKKRERGK-ERERKRKEREKQRKERREKERRKRKKEKKKRE 105

Query: 329 EGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAE-------- 380
                + E+K+  E++ ++   K+ R+        +    E + E E G+ E        
Sbjct: 106 RKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKK 165

Query: 381 EEKEEAEALKEKEKPKEEEWEKPKD 405
           EE+E+      KE+ KE E ++ ++
Sbjct: 166 EEREKKRERNRKERKKERERKERRE 190



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 35/134 (26%), Positives = 61/134 (45%), Gaps = 9/134 (6%)

Query: 271 EEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEG 330
           + E E+  +  E  K++  R      +  +K   K +K+E GK+ E         K+ E 
Sbjct: 31  QRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERER--------KRKER 82

Query: 331 DGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEALK 390
           +  ++E++E   ++ KK  KKR RK  G     +      E E E+ Q  E K +    K
Sbjct: 83  EKQRKERREKERRKRKKEKKKRERKQRGRRE-RKKKKERKERERENKQRRERKRKKRRKK 141

Query: 391 EKEKPKEEEWEKPK 404
           ++ K ++ E E+ K
Sbjct: 142 KRRKERKREKERGK 155



 Score = 38.1 bits (87), Expect = 0.036
 Identities = 27/93 (29%), Positives = 48/93 (51%), Gaps = 13/93 (13%)

Query: 3   DSDDEYDRRRRDKFRRERSDYDRSRE--------RDERRRGDDWNDREWDRGRERRSRGE 54
           +S+ + +RR R+K +RER + +R RE        R +R RG +   +  +R ++R+ R E
Sbjct: 33  ESERKKERREREKRKRER-EKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERRE 91

Query: 55  ----YRDYDRNRRERFSPPRHELSPPQKRMRRD 83
                R  ++ +RER    R E    ++R  R+
Sbjct: 92  KERRKRKKEKKKRERKQRGRRERKKKKERKERE 124



 Score = 37.0 bits (84), Expect = 0.080
 Identities = 27/87 (31%), Positives = 40/87 (45%), Gaps = 5/87 (5%)

Query: 9   DRRRRDKFRRERSDYDRSRE--RDERRRGDDWNDRE---WDRGRERRSRGEYRDYDRNRR 63
           +R R +K RRER    R ++  R ER+R  +   RE     R +E R +   R+    ++
Sbjct: 122 ERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKK 181

Query: 64  ERFSPPRHELSPPQKRMRRDWDEHSSD 90
           ER    R E    +K+ RR   E   D
Sbjct: 182 ERERKERRERKKERKKERRKKKERKKD 208



 Score = 36.6 bits (83), Expect = 0.10
 Identities = 22/77 (28%), Positives = 42/77 (54%), Gaps = 4/77 (5%)

Query: 10  RRRRDKFR-RERSDYDRSRERDERRRGDDWNDREWDRGRERRSRG---EYRDYDRNRRER 65
           R++R++ + RER   +R ++R ERR  +    ++  + RER+ RG     +  +R  RER
Sbjct: 66  RKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERER 125

Query: 66  FSPPRHELSPPQKRMRR 82
            +  R E    ++R ++
Sbjct: 126 ENKQRRERKRKKRRKKK 142



 Score = 36.6 bits (83), Expect = 0.10
 Identities = 19/76 (25%), Positives = 41/76 (53%), Gaps = 4/76 (5%)

Query: 7   EYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDRNRRERF 66
           E  R+ R+K R+ER + +R + + E+++     +R+    RER+ + E ++ +R  ++R 
Sbjct: 76  ERKRKEREKQRKERREKERRKRKKEKKK----RERKQRGRRERKKKKERKERERENKQRR 131

Query: 67  SPPRHELSPPQKRMRR 82
              R +    ++R  R
Sbjct: 132 ERKRKKRRKKKRRKER 147



 Score = 36.2 bits (82), Expect = 0.14
 Identities = 21/90 (23%), Positives = 38/90 (42%), Gaps = 7/90 (7%)

Query: 313 KQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESES 372
           K      S   K ++      +E +KE   +  KK  KKR ++       + G   E + 
Sbjct: 27  KPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKR-------ERGKERERKR 79

Query: 373 ESESGQAEEEKEEAEALKEKEKPKEEEWEK 402
           +    Q +E +E+    ++KEK K E  ++
Sbjct: 80  KEREKQRKERREKERRKRKKEKKKRERKQR 109



 Score = 35.4 bits (80), Expect = 0.23
 Identities = 23/78 (29%), Positives = 38/78 (48%), Gaps = 2/78 (2%)

Query: 333 DKEEKKEDSEKEAKKSSKKRNRKHS-GDDSFDEGSVSESESESESGQAEEEKEEAEAL-K 390
           + E KKE  E+E +K  +++ RK   G     +    E   E E  + E EK+  E   K
Sbjct: 33  ESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREK 92

Query: 391 EKEKPKEEEWEKPKDAAG 408
           E+ K K+E+ ++ +   G
Sbjct: 93  ERRKRKKEKKKRERKQRG 110



 Score = 35.0 bits (79), Expect = 0.30
 Identities = 21/74 (28%), Positives = 38/74 (51%), Gaps = 1/74 (1%)

Query: 10  RRRRDKFRRERSDYDRSRERDERRRGDDWNDRE-WDRGRERRSRGEYRDYDRNRRERFSP 68
           + RR+K RR+R    + RER +R R +    +E  +R RE + R E +   R +++R   
Sbjct: 87  KERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKE 146

Query: 69  PRHELSPPQKRMRR 82
            + E    ++  +R
Sbjct: 147 RKREKERGKRERKR 160



 Score = 33.9 bits (76), Expect = 0.68
 Identities = 24/85 (28%), Positives = 41/85 (48%), Gaps = 5/85 (5%)

Query: 3   DSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDY---- 58
           + + E  R R  K +++R   +R +ER ER+R +    R+  R +ERR R + +      
Sbjct: 49  EREKERKRERGKKEKKKRKKRERGKER-ERKRKEREKQRKERREKERRKRKKEKKKRERK 107

Query: 59  DRNRRERFSPPRHELSPPQKRMRRD 83
            R RRER      +    + + RR+
Sbjct: 108 QRGRRERKKKKERKERERENKQRRE 132



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 21/84 (25%), Positives = 41/84 (48%), Gaps = 7/84 (8%)

Query: 5   DDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGE-------YRD 57
           + E  +R+++K +RER    R   + ++ R +   + +  R R+R+ R +        R+
Sbjct: 91  EKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKRE 150

Query: 58  YDRNRRERFSPPRHELSPPQKRMR 81
            +R +RER    R +    +KR R
Sbjct: 151 KERGKRERKRKKRKKEEREKKRER 174



 Score = 30.8 bits (68), Expect = 5.7
 Identities = 18/54 (33%), Positives = 29/54 (53%), Gaps = 1/54 (1%)

Query: 7   EYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDR 60
           E  R++R K  RE+      +ER + R   +  +R+ +R +ERR + E R  DR
Sbjct: 157 ERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKE-RKKDR 209



 Score = 30.0 bits (66), Expect = 9.8
 Identities = 18/63 (28%), Positives = 35/63 (55%), Gaps = 2/63 (3%)

Query: 10  RRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDRNRRERFSPP 69
           +  R+K +RER+  +R +ER+ + R +   +R+ +R R+++ R + R  DR    +   P
Sbjct: 165 KEEREK-KRERNRKERKKERERKERRERKKERKKER-RKKKERKKDRKTDRQTDSQVFRP 222

Query: 70  RHE 72
             E
Sbjct: 223 LRE 225


>gi|91206454 hypothetical protein LOC257415 isoform 2 [Homo sapiens]
          Length = 237

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 44/147 (29%), Positives = 71/147 (48%), Gaps = 22/147 (14%)

Query: 266 RILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKT 325
           + L + EE+       E  K  E          +++   K EKK+ G+ + + SS+ D +
Sbjct: 46  KALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSS 105

Query: 326 KKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEE 385
             S  D + E+K     K+ K+  KK+NR H   +S    S+SE+ES+S+          
Sbjct: 106 SSSS-DSEDEDK-----KQGKRRKKKKNRSHKSSES----SMSETESDSK---------- 145

Query: 386 AEALKEKEKPKEEEWEKPKDAAGLECK 412
            ++LK+K+K K+   EK KD  GL  K
Sbjct: 146 -DSLKKKKKSKDGT-EKEKDIKGLSKK 170



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 43/161 (26%), Positives = 80/161 (49%), Gaps = 11/161 (6%)

Query: 257 MEGGTENDLRILEQEEEEEQAGK-PGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQA 315
           + G   +  +   +++E++++G+     S   +  + +   + E K   K  KK+  +  
Sbjct: 71  LSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSH 130

Query: 316 ENDSSNDDKTKKSEGDGDKEEKKE----DSEKEAKKSSKKRNRKHSGDDSFDEGSVSESE 371
           ++  S+  +T+    D  K++KK     + EK+ K  SKKR + +S D      S+SESE
Sbjct: 131 KSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKR-KMYSEDKPLSSESLSESE 189

Query: 372 SESE----SGQAEEEKEEA-EALKEKEKPKEEEWEKPKDAA 407
              E      ++ EE+E+A E  K+K+K K+   +K K AA
Sbjct: 190 YIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAA 230


>gi|91206456 hypothetical protein LOC257415 isoform 1 [Homo sapiens]
          Length = 247

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 44/147 (29%), Positives = 71/147 (48%), Gaps = 22/147 (14%)

Query: 266 RILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKT 325
           + L + EE+       E  K  E          +++   K EKK+ G+ + + SS+ D +
Sbjct: 56  KALAEFEEKMNENWKKELEKHREKLLSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSS 115

Query: 326 KKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEE 385
             S  D + E+K     K+ K+  KK+NR H   +S    S+SE+ES+S+          
Sbjct: 116 SSSS-DSEDEDK-----KQGKRRKKKKNRSHKSSES----SMSETESDSK---------- 155

Query: 386 AEALKEKEKPKEEEWEKPKDAAGLECK 412
            ++LK+K+K K+   EK KD  GL  K
Sbjct: 156 -DSLKKKKKSKDGT-EKEKDIKGLSKK 180



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 43/161 (26%), Positives = 80/161 (49%), Gaps = 11/161 (6%)

Query: 257 MEGGTENDLRILEQEEEEEQAGK-PGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQA 315
           + G   +  +   +++E++++G+     S   +  + +   + E K   K  KK+  +  
Sbjct: 81  LSGSESSSKKRQRKKKEKKKSGRYSSSSSSSSDSSSSSSDSEDEDKKQGKRRKKKKNRSH 140

Query: 316 ENDSSNDDKTKKSEGDGDKEEKKE----DSEKEAKKSSKKRNRKHSGDDSFDEGSVSESE 371
           ++  S+  +T+    D  K++KK     + EK+ K  SKKR + +S D      S+SESE
Sbjct: 141 KSSESSMSETESDSKDSLKKKKKSKDGTEKEKDIKGLSKKR-KMYSEDKPLSSESLSESE 199

Query: 372 SESE----SGQAEEEKEEA-EALKEKEKPKEEEWEKPKDAA 407
              E      ++ EE+E+A E  K+K+K K+   +K K AA
Sbjct: 200 YIEEVRAKKKKSSEEREKATEKTKKKKKHKKHSKKKKKKAA 240


>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
          Length = 843

 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 34/157 (21%), Positives = 73/157 (46%)

Query: 258 EGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAEN 317
           +G  E + + +E+E  E +  +  E  ++E  R      + E++   + E++ D  +   
Sbjct: 295 KGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRT 354

Query: 318 DSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESG 377
              + D+ ++ + D D+E   + ++  ++   K R+R+   +   +     E E E E  
Sbjct: 355 KERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERE 414

Query: 378 QAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECKPR 414
           +  E + E E  K+K++ +EE+ E   +   LE K R
Sbjct: 415 REREREREREREKDKKRDREEDEEDAYERRKLERKLR 451



 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 50/235 (21%), Positives = 98/235 (41%), Gaps = 33/235 (14%)

Query: 204 DEVGKRRQEARGALQNRLRVFLSLM-----ETGWFDNLLLDIDKADAIVKMLDAAVIKME 258
           +E  +R Q  +GA++  +R + S +     E+           K D   +   A +I   
Sbjct: 198 EETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYP 257

Query: 259 GGTENDLRILEQEEE-------------------EEQAGKPG----EPSKKEEGRAGAGL 295
             T+ D+  +E EE+                   EE+ GK      E  K+   R     
Sbjct: 258 LITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERE 317

Query: 296 GDGERKTNDKDEKKEDGKQAENDSSND-----DKTKKSEGDGDKEEKKEDSEKEAKKSSK 350
            + ER+  +++ ++E  ++ E +   +     D+ +  E D D++ +++      + S +
Sbjct: 318 RERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDR 377

Query: 351 KRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKD 405
            ++R  S + S D     E E E E  +  E + E E  +E+E+ +E E +K +D
Sbjct: 378 NKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRD 432



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 31/145 (21%), Positives = 69/145 (47%), Gaps = 8/145 (5%)

Query: 262 ENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGER-KTNDKDEKKEDGKQAENDSS 320
           E + R  E+E E E+  +  +  ++E  R      D +R K  D+D  +E  +  + + S
Sbjct: 319 ERERREREREREREREREKEKERERERERDR----DRDRTKERDRDRDRERDRDRDRERS 374

Query: 321 ND---DKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESG 377
           +D   D+++  E   D+E ++E   +  ++  ++R R+   +   +     E + + +  
Sbjct: 375 SDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDRE 434

Query: 378 QAEEEKEEAEALKEKEKPKEEEWEK 402
           + EE+  E   L+ K + KE  +++
Sbjct: 435 EDEEDAYERRKLERKLREKEAAYQE 459



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 33/91 (36%), Positives = 45/91 (49%), Gaps = 3/91 (3%)

Query: 3   DSDDEYDRRR-RDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRER-RSRGEYRDYDR 60
           + + E +R R RD+ R +  D DR RERD  R  +  +DR  DR R R +SR   R+ +R
Sbjct: 338 EKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERER 397

Query: 61  NR-RERFSPPRHELSPPQKRMRRDWDEHSSD 90
            R RER      E    ++R R    E   D
Sbjct: 398 EREREREREREREREREREREREREREREKD 428



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 30/84 (35%), Positives = 46/84 (54%), Gaps = 9/84 (10%)

Query: 7   EYDRRRRDKFR---RERSDYDRSRERDERRRGDDWNDREWDRGRER-RSRGEYRDYDRNR 62
           E +RR R++ R   RER + +R RER+  R  +   +RE +R R+R R++   RD DR R
Sbjct: 306 EKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRER 365

Query: 63  -----RERFSPPRHELSPPQKRMR 81
                RER S    + S  +++ R
Sbjct: 366 DRDRDRERSSDRNKDRSRSREKSR 389



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 30/160 (18%), Positives = 72/160 (45%), Gaps = 14/160 (8%)

Query: 269 EQEEEEEQAGKPGEPSKKEEGRAGAGLGDGER-----KTNDKDEKKEDGKQAENDSSND- 322
           ++E + ++  +      K+  R+     D ER     +  +++ ++E  ++ E +   + 
Sbjct: 362 DRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERERERERER 421

Query: 323 DKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVS--------ESESES 374
           ++ ++ +   D+EE +ED+ +  K   K R ++ +  +      +         E E+E 
Sbjct: 422 EREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAER 481

Query: 375 ESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECKPR 414
           E  +  E  +EA+ LKE  +  +++ + PK   G   + R
Sbjct: 482 EEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKR 521



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 31/91 (34%), Positives = 44/91 (48%), Gaps = 13/91 (14%)

Query: 3   DSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRER-----------RS 51
           + + E +R R  +  RER + +R R+RD  +  D   DRE DR R+R           RS
Sbjct: 326 EREREREREREKEKERER-ERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRS 384

Query: 52  RGEYRDYDRNR-RERFSPPRHELSPPQKRMR 81
           R + RD +R R RER      E    ++R R
Sbjct: 385 REKSRDRERERERERERERERERERERERER 415



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 39/174 (22%), Positives = 79/174 (45%), Gaps = 12/174 (6%)

Query: 264 DLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDD 323
           ++R  ++  E E+  +  E  ++E  +    L   +    D D+ ++D K     S+   
Sbjct: 465 EIRERKKTREYEKEAEREEERRREMAKEAKRL---KEFLEDYDDDRDDPKYYRG-SALQK 520

Query: 324 KTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEK 383
           + +  E + + +E+    EKE  +  ++R       D   E    E E+E       +++
Sbjct: 521 RLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQE 580

Query: 384 EEAEALKEKEKPKEEEWEKPKDAAGLECKPRPLHKTC---SLFMRNIAPNISRA 434
            E+E  +E+++ KEE+ E+P     +E +  P  K C   +L   + AP++S A
Sbjct: 581 PESEEEEEEKQEKEEKREEP-----MEEEEEPEQKPCLKPTLRPISSAPSVSSA 629



 Score = 37.7 bits (86), Expect = 0.047
 Identities = 29/83 (34%), Positives = 43/83 (51%), Gaps = 9/83 (10%)

Query: 11  RRRDKFRRERSDYDRSRERD-ERRRGDDWNDREWDRGRER-RSRGEYRDYDRNRRERFSP 68
           + R +  +ER + +R RER+ ERR  +   +RE +R +E+ R R   RD DR+R +    
Sbjct: 300 KERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDR 359

Query: 69  PRHELSPPQKRMRRDWD-EHSSD 90
            R       +   RD D E SSD
Sbjct: 360 DR------DRERDRDRDRERSSD 376



 Score = 37.4 bits (85), Expect = 0.061
 Identities = 24/89 (26%), Positives = 42/89 (47%), Gaps = 1/89 (1%)

Query: 3   DSDDEYDRRRRDKFRRERS-DYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDRN 61
           D + E +R R  +  RER  + +R RER+  R  +   D++ DR  +     E R  +R 
Sbjct: 390 DREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLERK 449

Query: 62  RRERFSPPRHELSPPQKRMRRDWDEHSSD 90
            RE+ +  +  L   + R R+   E+  +
Sbjct: 450 LREKEAAYQERLKNWEIRERKKTREYEKE 478



 Score = 36.6 bits (83), Expect = 0.10
 Identities = 24/62 (38%), Positives = 34/62 (54%), Gaps = 2/62 (3%)

Query: 4   SDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRER-RSRGEYRDYDRNR 62
           SD   DR R  +  R+R + +R RER+  R  +   +RE +R RER R R   +D  R+R
Sbjct: 375 SDRNKDRSRSREKSRDR-EREREREREREREREREREREREREREREREREREKDKKRDR 433

Query: 63  RE 64
            E
Sbjct: 434 EE 435



 Score = 35.0 bits (79), Expect = 0.30
 Identities = 29/116 (25%), Positives = 55/116 (47%), Gaps = 25/116 (21%)

Query: 3   DSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGR--------------- 47
           + + E +R R  +  RER + +R RE+D++R  ++  +  ++R +               
Sbjct: 402 ERERERERERERERERER-EREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQER 460

Query: 48  ----ERRSRGEYRDYDRNRRERFSPPRHELSPPQKRMR---RDWDEHSSDP-YHSG 95
               E R R + R+Y++   ER    R E++   KR++    D+D+   DP Y+ G
Sbjct: 461 LKNWEIRERKKTREYEK-EAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRG 515



 Score = 35.0 bits (79), Expect = 0.30
 Identities = 28/147 (19%), Positives = 62/147 (42%), Gaps = 4/147 (2%)

Query: 269 EQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKS 328
           E+E E E+  +  +   +EE    A     ER+  ++  ++++    E   + + + +K 
Sbjct: 416 EREREREREREKDKKRDREEDEEDAY----ERRKLERKLREKEAAYQERLKNWEIRERKK 471

Query: 329 EGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEA 388
             + +KE ++E+  +       KR ++   D   D          +   +  + ++E EA
Sbjct: 472 TREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEA 531

Query: 389 LKEKEKPKEEEWEKPKDAAGLECKPRP 415
            +   K ++EE E+ +     E  P P
Sbjct: 532 DERDRKREKEELEEIRQRLLAEGHPDP 558



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 19/60 (31%), Positives = 30/60 (50%), Gaps = 5/60 (8%)

Query: 11  RRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRER-----RSRGEYRDYDRNRRER 65
           R R++ R    + +R RER+  R  +   +RE +R RE+     R   E   Y+R + ER
Sbjct: 389 RDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKLER 448



 Score = 32.3 bits (72), Expect = 2.0
 Identities = 18/59 (30%), Positives = 31/59 (52%), Gaps = 7/59 (11%)

Query: 6   DEYDRRRRDKFRRERSDYDRSRERDERRRGDDWNDREWDRGRERRSRGEYRDYDRNRRE 64
           D + +   +K ++E+   +  +ER ER       +RE +R RERR R   R+ +R R +
Sbjct: 286 DTHKKLEEEKGKKEKERQEIEKERRER-------ERERERERERREREREREREREREK 337


>gi|4557509 cylicin 2 [Homo sapiens]
          Length = 348

 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 42/141 (29%), Positives = 71/141 (50%), Gaps = 11/141 (7%)

Query: 258 EGGTENDLRILEQEEE-------EEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKE 310
           +GGTE D +  +++ +       E QA K  E  K E+G+  A  GD E K   KD K+ 
Sbjct: 210 KGGTEKDSKKGKKDSKKGKDSAIELQAVKADE-KKDEDGKKDANKGD-ESKDAKKDAKEI 267

Query: 311 DGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSES 370
             K+ + D      T     D  K+E K+D+ K+AKK +KK   K S D   D    ++ 
Sbjct: 268 --KKGKKDKKKPSSTDSDSKDDVKKESKKDATKDAKKVAKKDTEKESADSKKDAKKNAKK 325

Query: 371 ESESESGQAEEEKEEAEALKE 391
           +++ ++ +  ++ E+ +A K+
Sbjct: 326 DAKKDAKKNAKKDEKKDAKKK 346



 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 43/153 (28%), Positives = 76/153 (49%), Gaps = 19/153 (12%)

Query: 269 EQEEEEEQAGKPGEPSKKE--EGRAGAGLGDGERKTNDKDEKK--EDGKQAENDSSNDDK 324
           E E+E+  A K  +  KK+  +G+  A   +GE+   +KD KK  +D K+ ++ +     
Sbjct: 177 ESEDEKGGAKKDNKKDKKDSNKGKDSATESEGEKGGTEKDSKKGKKDSKKGKDSAIELQA 236

Query: 325 TK---KSEGDGDKEEKKEDSEKEAKKSS------KKRNRKHSGDDSFDEGSVSESESESE 375
            K   K + DG K+  K D  K+AKK +      KK  +K S  DS  +  V +   +  
Sbjct: 237 VKADEKKDEDGKKDANKGDESKDAKKDAKEIKKGKKDKKKPSSTDSDSKDDVKKESKKDA 296

Query: 376 SGQAEE------EKEEAEALKEKEKPKEEEWEK 402
           +  A++      EKE A++ K+ +K  +++ +K
Sbjct: 297 TKDAKKVAKKDTEKESADSKKDAKKNAKKDAKK 329



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 39/140 (27%), Positives = 68/140 (48%), Gaps = 13/140 (9%)

Query: 266 RILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKK----EDGKQAENDSSN 321
           R +E + +  + GK GE    ++    +   + E K   KD KK    E GK+ + D+  
Sbjct: 103 RTVEVDSKAAEIGKKGEDKTTQKDTTDS---ESELKQGKKDSKKGKDIEKGKEEKLDAKK 159

Query: 322 DDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEE 381
           D K  K + +  K+   E  ++  K  +KK N+K   D +  +G  S +ESE E G  E+
Sbjct: 160 DSKKGKKDAEKGKDSATESEDE--KGGAKKDNKKDKKDSN--KGKDSATESEGEKGGTEK 215

Query: 382 EKEEAEALKEKEKPKEEEWE 401
           + ++ +  K+ +K K+   E
Sbjct: 216 DSKKGK--KDSKKGKDSAIE 233



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 39/144 (27%), Positives = 70/144 (48%), Gaps = 9/144 (6%)

Query: 268 LEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKK 327
           +E+ +EE+   K  + SKK +  A  G        ++K   K+D K+ + D SN  K   
Sbjct: 147 IEKGKEEKLDAK--KDSKKGKKDAEKGKDSATESEDEKGGAKKDNKKDKKD-SNKGKDSA 203

Query: 328 SEGDGDKEEKKEDSEKEAKKSSKKRN-----RKHSGDDSFDEGSVSESESESESGQAEEE 382
           +E +G+K   ++DS+K  K S K ++     +    D+  DE    ++    ES  A+++
Sbjct: 204 TESEGEKGGTEKDSKKGKKDSKKGKDSAIELQAVKADEKKDEDGKKDANKGDESKDAKKD 263

Query: 383 -KEEAEALKEKEKPKEEEWEKPKD 405
            KE  +  K+K+KP   + +   D
Sbjct: 264 AKEIKKGKKDKKKPSSTDSDSKDD 287



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 37/148 (25%), Positives = 74/148 (50%), Gaps = 10/148 (6%)

Query: 268 LEQEEEEEQAGKPGEPSKKEEGRAGA----GLGDGERKTNDKDEKKEDGKQAENDSSND- 322
           L+Q +++ + GK  E  K+E+  A      G  D E+  +   E +++   A+ D+  D 
Sbjct: 134 LKQGKKDSKKGKDIEKGKEEKLDAKKDSKKGKKDAEKGKDSATESEDEKGGAKKDNKKDK 193

Query: 323 -DKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEE 381
            D  K  +   + E +K  +EK++KK   K++ K   D + +  +V   E + E G+ + 
Sbjct: 194 KDSNKGKDSATESEGEKGGTEKDSKKG--KKDSKKGKDSAIELQAVKADEKKDEDGKKDA 251

Query: 382 EK--EEAEALKEKEKPKEEEWEKPKDAA 407
            K  E  +A K+ ++ K+ + +K K ++
Sbjct: 252 NKGDESKDAKKDAKEIKKGKKDKKKPSS 279



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 26/95 (27%), Positives = 47/95 (49%)

Query: 308 KKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSV 367
           KK + K  + D+++ +   K      K+ K  +  KE K  +KK ++K   D    + S 
Sbjct: 116 KKGEDKTTQKDTTDSESELKQGKKDSKKGKDIEKGKEEKLDAKKDSKKGKKDAEKGKDSA 175

Query: 368 SESESESESGQAEEEKEEAEALKEKEKPKEEEWEK 402
           +ESE E    + + +K++ ++ K K+   E E EK
Sbjct: 176 TESEDEKGGAKKDNKKDKKDSNKGKDSATESEGEK 210



 Score = 38.5 bits (88), Expect = 0.027
 Identities = 24/82 (29%), Positives = 42/82 (51%), Gaps = 7/82 (8%)

Query: 279 KPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDS------SNDDKTKKSEGDG 332
           K G+  KK+     +   D  +K + KD  K+  K A+ D+      S  D  K ++ D 
Sbjct: 268 KKGKKDKKKPSSTDSDSKDDVKKESKKDATKDAKKVAKKDTEKESADSKKDAKKNAKKDA 327

Query: 333 DKEEKKEDSEKEAKKSSKKRNR 354
            K+ KK +++K+ KK +KK+ +
Sbjct: 328 KKDAKK-NAKKDEKKDAKKKGK 348



 Score = 30.0 bits (66), Expect = 9.8
 Identities = 18/58 (31%), Positives = 30/58 (51%), Gaps = 5/58 (8%)

Query: 349 SKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDA 406
           SK       G+D   +   ++SESE + G+ + +K      K+ EK KEE+ +  KD+
Sbjct: 109 SKAAEIGKKGEDKTTQKDTTDSESELKQGKKDSKKG-----KDIEKGKEEKLDAKKDS 161


>gi|46852388 cell-cycle and apoptosis regulatory protein 1 [Homo
           sapiens]
          Length = 1150

 Score = 57.4 bits (137), Expect = 6e-08
 Identities = 39/122 (31%), Positives = 61/122 (50%), Gaps = 17/122 (13%)

Query: 299 ERKTNDKDEKKED--GKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKH 356
           ++K  DK  KK++   K+ E D   D+   K    GD ++KKED ++  K+  +K     
Sbjct: 798 DKKEKDKKSKKDERKDKKEERDDETDEPKPKRRKSGDDKDKKEDRDERKKEDKRK----- 852

Query: 357 SGDDSFDEGSVSESESESESGQAEEEKEEAEALKEKEKPK-EEEWEKPKDAAGLE--CKP 413
             DDS D     + E+E ++ Q E +  EAE  +++E  + EEE  K  D   +   CK 
Sbjct: 853 --DDSKD-----DDETEEDNNQDEYDPMEAEEAEDEEDDRDEEEMTKRDDKRDINRYCKE 905

Query: 414 RP 415
           RP
Sbjct: 906 RP 907



 Score = 34.3 bits (77), Expect = 0.52
 Identities = 23/90 (25%), Positives = 41/90 (45%), Gaps = 3/90 (3%)

Query: 3   DSDDEYDRRRRDKFRRERSDYDRSRERDERRRGDDWND--REWDRGRERRSRGEYRDYDR 60
           + DDE D  +  K R+   D D+  +RDER++ D   D  ++ D   E  ++ EY   + 
Sbjct: 817 ERDDETDEPK-PKRRKSGDDKDKKEDRDERKKEDKRKDDSKDDDETEEDNNQDEYDPMEA 875

Query: 61  NRRERFSPPRHELSPPQKRMRRDWDEHSSD 90
              E     R E    ++  +RD + +  +
Sbjct: 876 EEAEDEEDDRDEEEMTKRDDKRDINRYCKE 905



 Score = 30.4 bits (67), Expect = 7.5
 Identities = 23/60 (38%), Positives = 28/60 (46%), Gaps = 4/60 (6%)

Query: 26  SRERDERRRGDDWNDREWDRGRER---RSRGEYRDYDRNRRERFSPPRHELSPPQKRMRR 82
           SR      RGD   +R+ DR RER   R R   R   R +R R   PR E     +R+RR
Sbjct: 299 SRFSGRNDRGDQVPNRKDDRSRERERERRRSRERSPQR-KRSRERSPRRERERSPRRVRR 357


>gi|156104891 general transcription factor IIF, polypeptide 1, 74kDa
           [Homo sapiens]
          Length = 517

 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 44/152 (28%), Positives = 72/152 (47%), Gaps = 19/152 (12%)

Query: 263 NDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSND 322
           ++LRI + E++ E +    + S +E GR          K   K    + G++ +    +D
Sbjct: 203 SELRIHDLEDDLEMSSDASDASGEEGGRVP--------KAKKKAPLAKGGRKKKKKKGSD 254

Query: 323 DKTKKSEGDGDKEEKKED-------SEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESE 375
           D+  +   DGD E ++ D       S +E  +S  K  ++  G    DE S S  ESE E
Sbjct: 255 DEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEE 314

Query: 376 SGQAEEEKEEAEALKEKEKPKEEEWEKPKDAA 407
               EE+KEE E   EK+ P  +E ++ KD++
Sbjct: 315 K-PPEEDKEEEE---EKKAPTPQEKKRRKDSS 342



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 32/116 (27%), Positives = 49/116 (42%), Gaps = 14/116 (12%)

Query: 288 EGRAGAGLGDGERKTNDKDEKKEDGKQAEN-----DSSNDDKTKKSEGDGDKEEKKEDSE 342
           EG+    + DG   + ++ E K    Q E      D  +D   +  E    +E+K+E+ E
Sbjct: 267 EGQEVDYMSDGSSSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEE 326

Query: 343 KEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEE 398
           K+A    +K+ RK S +         ES+S  ES    E        K+K  PK E
Sbjct: 327 KKAPTPQEKKRRKDSSE---------ESDSSEESDIDSEASSALFMAKKKTPPKRE 373



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 40/160 (25%), Positives = 68/160 (42%), Gaps = 30/160 (18%)

Query: 263 NDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSND 322
           N   I++Q   ++Q     E  K++ GR  A     E + +D ++  E    A + S  +
Sbjct: 172 NHFSIMQQRRLKDQDQDEDEEEKEKRGRRKAS----ELRIHDLEDDLEMSSDASDASGEE 227

Query: 323 DKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFD-------EGSVSESESESE 375
                    G +  K +     AK   KK+ +K S D++F+       EG   +  S+  
Sbjct: 228 ---------GGRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGS 278

Query: 376 SGQAEEEKEEAEALKEKEKPK----------EEEWEKPKD 405
           S   EE + +A+A +++E PK          E E EKP +
Sbjct: 279 SSSQEEPESKAKAPQQEEGPKGVDEQSDSSEESEEEKPPE 318



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 35/126 (27%), Positives = 56/126 (44%), Gaps = 31/126 (24%)

Query: 270 QEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSE 329
           QEE E +A  P    ++EEG  G        + +D  E+ E+ K  E             
Sbjct: 282 QEEPESKAKAP----QQEEGPKGVD------EQSDSSEESEEEKPPE------------- 318

Query: 330 GDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEAL 389
                E+K+E+ EK+A    +K+ RK S ++S    S  ES+ +SE+  A    ++    
Sbjct: 319 -----EDKEEEEEKKAPTPQEKKRRKDSSEES---DSSEESDIDSEASSALFMAKKKTPP 370

Query: 390 KEKEKP 395
           K + KP
Sbjct: 371 KRERKP 376



 Score = 36.6 bits (83), Expect = 0.10
 Identities = 40/146 (27%), Positives = 58/146 (39%), Gaps = 18/146 (12%)

Query: 258 EGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAEN 317
           EG    D +    EE EE+  KP E  K+EE          E+K     EKK     +E 
Sbjct: 296 EGPKGVDEQSDSSEESEEE--KPPEEDKEEE---------EEKKAPTPQEKKRRKDSSEE 344

Query: 318 DSSNDDKTKKSEGDGD--KEEKKEDSEKEAKKS-SKKRNRKHSGDDSFDEGSVSE----S 370
             S+++    SE        +KK   ++E K S    R     G  S + GS S     +
Sbjct: 345 SDSSEESDIDSEASSALFMAKKKTPPKRERKPSGGSSRGNSRPGTPSAEGGSTSSTLRAA 404

Query: 371 ESESESGQAEEEKEEAEALKEKEKPK 396
            S+ E G+   E   A+ L+    P+
Sbjct: 405 ASKLEQGKRVSEMPAAKRLRLDTGPQ 430


>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
          Length = 1020

 Score = 56.6 bits (135), Expect = 1e-07
 Identities = 49/186 (26%), Positives = 81/186 (43%), Gaps = 23/186 (12%)

Query: 251 DAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKE 310
           DA   + E   + +++   +EEE+ Q  K  EP KK E        + +     K E+K+
Sbjct: 806 DAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAE--------EEKAPATPKTEEKK 857

Query: 311 DGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRK------------HSG 358
           D K+ E       K K  E      EK ++S+ EAKK   +  +K               
Sbjct: 858 DSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVK 917

Query: 359 DDSFDEGSVSESESESESGQAEEEK---EEAEALKEKEKPKEEEWEKPKDAAGLECKPRP 415
           +D+  +     ++ E +  +A+E     E+ EA  EK+  KEE+ +KP++    E K + 
Sbjct: 918 EDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKE 977

Query: 416 LHKTCS 421
             KT S
Sbjct: 978 DDKTLS 983



 Score = 50.1 bits (118), Expect = 9e-06
 Identities = 45/176 (25%), Positives = 82/176 (46%), Gaps = 18/176 (10%)

Query: 246 IVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEG--RAGAGLGDGERKTN 303
           +V+  +   + +E  TE + ++ E+  EEE+     E  K+EEG     A  G+ E K+ 
Sbjct: 446 VVEKSEKETVIVEEQTE-ETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEGGEEETKSP 504

Query: 304 DKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFD 363
             +E     K+A++    + K+       +KEE K  +E ++ + +K   ++        
Sbjct: 505 PAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEE------- 557

Query: 364 EGSVSESESESESGQAEEEKEEAEALKEKEK---PKEEEWEKPKDAAGLECKPRPL 416
               ++S  E++S + EE K  AE +K  EK   P +EE + P +A   E    P+
Sbjct: 558 ----AKSPPEAKSPEKEEAKSPAE-VKSPEKAKSPAKEEAKSPAEAKSPEKAKSPV 608



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 42/152 (27%), Positives = 69/152 (45%), Gaps = 7/152 (4%)

Query: 269  EQEEEEEQAGKPGEPSKK-EEGRAGAGLGDGERKTNDKDEKKEDGKQA---ENDSSNDDK 324
            +++ ++E+A K   P  K EE +  A     E K   K E+ ED K+    E ++    +
Sbjct: 856  KKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVE 915

Query: 325  TKKSEGDGDKEE--KKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEE 382
             K+     +K E  KKE  + +AK+ SK   +K +  +  D       + E +     + 
Sbjct: 916  VKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKA 975

Query: 383  KEEAEAL-KEKEKPKEEEWEKPKDAAGLECKP 413
            KE+ + L KE  KPK E+ EK       + KP
Sbjct: 976  KEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKP 1007



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 43/164 (26%), Positives = 72/164 (43%), Gaps = 15/164 (9%)

Query: 258 EGGTENDLRILEQEEEEEQAGKPGEPSK------KEEGRAGAGLGDGERKTNDKDEKKED 311
           EGG E +    E+E +   A +   P K      KEE ++ A     E K+ +K+E K  
Sbjct: 487 EGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPA-----EAKSPEKEEAKSP 541

Query: 312 GKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESE 371
              AE  S    K+   E      E K   ++EAK  ++ ++ + +   + +E   S +E
Sbjct: 542 ---AEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAK-SPAE 597

Query: 372 SESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECKPRP 415
           ++S        KEEA++  E + P +EE + P +    E    P
Sbjct: 598 AKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSP 641



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 47/178 (26%), Positives = 82/178 (46%), Gaps = 16/178 (8%)

Query: 241  DKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQA-GKPGEP---SKKEEGRAGAGLG 296
            +KA A  K  +    K E   + +    + EE++E A  KP E    +KKEE      + 
Sbjct: 845  EKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVP 904

Query: 297  DGERKTNDKDEKKEDGKQAE---------NDSSNDDKTKKSEGDGDKEEKKEDSEKEAKK 347
              E++   K E KED K  E         +D+   + +K +E      EKK+  E++AKK
Sbjct: 905  TPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKK 964

Query: 348  SSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKE-EAEALKEKEKPKEEEWEKPK 404
              +K   +    +  D+ ++S+  S+ ++ +AE+    + +  K  EK  E++  K K
Sbjct: 965  PEEKPKTEAKAKE--DDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDKAAKGK 1020



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 33/139 (23%), Positives = 60/139 (43%), Gaps = 5/139 (3%)

Query: 274 EEQAGKPGEPS--KKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGD 331
           +E+A  P E    +KEE ++ A +   E+    K   KE+ K      S + +  KS  +
Sbjct: 521 KEEAKSPAEAKSPEKEEAKSPAEVKSPEKA---KSPAKEEAKSPPEAKSPEKEEAKSPAE 577

Query: 332 GDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEALKE 391
               EK +   KE  KS  +            E + S +E++S   +  +   E ++ ++
Sbjct: 578 VKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEK 637

Query: 392 KEKPKEEEWEKPKDAAGLE 410
            + P +EE + P+ A   E
Sbjct: 638 AKSPTKEEAKSPEKAKSPE 656



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 36/139 (25%), Positives = 61/139 (43%), Gaps = 11/139 (7%)

Query: 273 EEEQAGKPGEPSKKEEGRAGA---GLGDGERKTNDKDEKKE--DGKQAENDSSNDDKTKK 327
           E+E+A  P E    E+ ++ A        E K+ +K+E K   + K  E   S   +  K
Sbjct: 534 EKEEAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAK 593

Query: 328 SEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAE 387
           S  +    EK +   KE  KS  +            E + S +E +S        KEEA+
Sbjct: 594 SPAEAKSPEKAKSPVKEEAKSPAE------AKSPVKEEAKSPAEVKSPEKAKSPTKEEAK 647

Query: 388 ALKEKEKPKEEEWEKPKDA 406
           + ++ + P++EE + P+ A
Sbjct: 648 SPEKAKSPEKEEAKSPEKA 666



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 35/128 (27%), Positives = 56/128 (43%), Gaps = 5/128 (3%)

Query: 275 EQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDK 334
           E+A  P +   K   +A + L +  +    +  KKE+ K    +     + K  E     
Sbjct: 783 EKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKA 842

Query: 335 EEKKEDS--EKEAKKSSKKRN--RKHSGDDSFDEGSVSESESESESGQAEEEKEEAEALK 390
           EE+K  +  + E KK SKK    +K +     +E      E   ES + E +KEEAE  K
Sbjct: 843 EEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKES-KVEAKKEEAEDKK 901

Query: 391 EKEKPKEE 398
           +   P++E
Sbjct: 902 KVPTPEKE 909



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 38/146 (26%), Positives = 67/146 (45%), Gaps = 9/146 (6%)

Query: 274 EEQAGKPGEPSK--KEEGRAGAGLGDGER-KTNDKDEKK--EDGKQAENDSSNDDKTKKS 328
           +E+A  P E     KEE ++ A +   E+ K+  K+E K  E  K  E + +   +  KS
Sbjct: 609 KEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKS 668

Query: 329 --EGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEE--KE 384
             + +    EK +   K   KS +K       +    E + S  + E++S +  +   KE
Sbjct: 669 PVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKE 728

Query: 385 EAEALKEKEKPKEEEWEKPKDAAGLE 410
           EA+  ++ + P +EE + P+ A   E
Sbjct: 729 EAKTPEKAKSPVKEEAKSPEKAKSPE 754



 Score = 39.3 bits (90), Expect = 0.016
 Identities = 39/152 (25%), Positives = 66/152 (43%), Gaps = 3/152 (1%)

Query: 255 IKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQ 314
           +K E  +    +  E+ +  +      +   KEE R+ A     + K+  K+E K   K 
Sbjct: 740 VKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEK- 798

Query: 315 AENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESES 374
           A++    D K  + E    KEE K   ++E K    K        +     +  ++E + 
Sbjct: 799 AKSPLKEDAKAPEKEIP-KKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKK 857

Query: 375 ESGQAEEEKEEAEALKEKEKPKEEEWEKPKDA 406
           +S + E  K+EA   K +EK KE   EKPK++
Sbjct: 858 DSKKEEAPKKEAPKPKVEEK-KEPAVEKPKES 888



 Score = 38.1 bits (87), Expect = 0.036
 Identities = 38/139 (27%), Positives = 60/139 (43%), Gaps = 7/139 (5%)

Query: 267 ILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTK 326
           + E+ +  E+A  P +   K   +A + + + E K+ +K +  E  K  +  S       
Sbjct: 712 VKEEAKSPEKAKSPVKEEAKTPEKAKSPVKE-EAKSPEKAKSPEKAKTLDVKSPEAKTPA 770

Query: 327 KSEGDGDKE---EKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEK 383
           K E     +   EK +   KE  KS +K       D    E  + + E E +S   EEEK
Sbjct: 771 KEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKE-EVKSPVKEEEK 829

Query: 384 EEAEALKEKEKPKEEEWEK 402
            +   +K KE PK+ E EK
Sbjct: 830 PQE--VKVKEPPKKAEEEK 846



 Score = 37.4 bits (85), Expect = 0.061
 Identities = 33/136 (24%), Positives = 64/136 (47%), Gaps = 11/136 (8%)

Query: 272 EEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQ-AENDSSNDDKTKKSEG 330
           +EE ++    +  +KEE ++ A +   E+    K   KE+ K  AE  S    K+   E 
Sbjct: 555 KEEAKSPPEAKSPEKEEAKSPAEVKSPEKA---KSPAKEEAKSPAEAKSPEKAKSPVKEE 611

Query: 331 DGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEALK 390
                E K   ++EAK  ++ ++ + +        S ++ E++S       EKEEA++ +
Sbjct: 612 AKSPAEAKSPVKEEAKSPAEVKSPEKA-------KSPTKEEAKSPEKAKSPEKEEAKSPE 664

Query: 391 EKEKPKEEEWEKPKDA 406
           + + P + E + P+ A
Sbjct: 665 KAKSPVKAEAKSPEKA 680



 Score = 35.8 bits (81), Expect = 0.18
 Identities = 32/138 (23%), Positives = 58/138 (42%), Gaps = 5/138 (3%)

Query: 272 EEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGD 331
           +EE ++ +  +  +KEE ++        +      EK +   +AE  S    K+   E +
Sbjct: 643 KEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKE-E 701

Query: 332 GDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEALK- 390
               EK +   KE  KS +K       +    E + S  + E++S +  +  E+A+ L  
Sbjct: 702 AKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDV 761

Query: 391 ---EKEKPKEEEWEKPKD 405
              E + P +EE   P D
Sbjct: 762 KSPEAKTPAKEEARSPAD 779



 Score = 35.8 bits (81), Expect = 0.18
 Identities = 41/169 (24%), Positives = 71/169 (42%), Gaps = 7/169 (4%)

Query: 241 DKADAIVKMLDAAVIKMEGGTENDLRILEQEEE--EEQAGKPGEPSKKEEGRAGAGLGDG 298
           +KA + VK    +  K +   + + +  E+ +   +E+A  P E +K  E      +   
Sbjct: 706 EKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSP-EKAKSPEKAKTLDVKSP 764

Query: 299 ERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSG 358
           E KT  K+E +    +    + +  K +    +  K   KED++   K+  KK   K   
Sbjct: 765 EAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPV 824

Query: 359 DDSFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAA 407
            +   E    E + +    +AEEEK  A   K +EK   ++ E PK  A
Sbjct: 825 KE---EEKPQEVKVKEPPKKAEEEKAPATP-KTEEKKDSKKEEAPKKEA 869



 Score = 34.3 bits (77), Expect = 0.52
 Identities = 36/143 (25%), Positives = 59/143 (41%), Gaps = 6/143 (4%)

Query: 269 EQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEK--KEDGKQAENDSSNDDKTK 326
           E+ +  E+A  P +   K   +A + +   E K+ +K +   KE+ K  E   S   +  
Sbjct: 658 EEAKSPEKAKSPVKAEAKSPEKAKSPV-KAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEA 716

Query: 327 KSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDE--GSVSESESESESGQAEEEKE 384
           KS        K+E    E  KS  K   K        E   ++     E+++   EE + 
Sbjct: 717 KSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARS 776

Query: 385 EAEALKEKEK-PKEEEWEKPKDA 406
            A+   EK K P +EE + P+ A
Sbjct: 777 PADKFPEKAKSPVKEEVKSPEKA 799



 Score = 31.6 bits (70), Expect = 3.4
 Identities = 21/68 (30%), Positives = 34/68 (50%), Gaps = 2/68 (2%)

Query: 338 KEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEE--KEEAEALKEKEKP 395
           K  SE++ K   K        ++  +E  V+E  +E E  +A+EE  KEE    +E+ + 
Sbjct: 437 KVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEG 496

Query: 396 KEEEWEKP 403
            EEE + P
Sbjct: 497 GEEETKSP 504


>gi|27734775 hypothetical protein LOC286499 [Homo sapiens]
          Length = 248

 Score = 56.2 bits (134), Expect = 1e-07
 Identities = 42/162 (25%), Positives = 80/162 (49%), Gaps = 8/162 (4%)

Query: 248 KMLDAAVIKMEGGTENDLRILEQEEEEEQAG--KPGEPSKKEEGRAGAGLGDGERKTNDK 305
           K L+ +  K+  G E+  +  E++++ ++         S  +   + +   D E+K   +
Sbjct: 71  KELEKSREKLLSGNESSSKKRERKKKRKKKSCRSSSSSSSSDSSSSSSDSEDEEKKQGKR 130

Query: 306 DEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDS---EKEAKKSSKKRNRKHSGDDSF 362
            +KK++     + SS  +   +S+    K++K +D    EK+ +  SKKR + +  D   
Sbjct: 131 RKKKKNRSYKSSQSSTHESESESKESVKKKKKSKDETEKEKDVRSLSKKRKKSYPDDKPL 190

Query: 363 DEGSVSESESESESGQAEEEK--EEAEALKEKEKPKEEEWEK 402
              S SES+ E E  QA++++  EE E  KEK K K+++  K
Sbjct: 191 SSESSSESDYE-EDVQAKKKRRCEEREQAKEKVKKKKKKQHK 231



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 43/134 (32%), Positives = 61/134 (45%), Gaps = 18/134 (13%)

Query: 279 KPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKK 338
           K  E  KKE  ++   L  G   ++ K E+K+  K+    SS+      S    D     
Sbjct: 64  KMNENWKKELEKSREKLLSGNESSSKKRERKKKRKKKSCRSSS------SSSSSDSSSSS 117

Query: 339 EDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEE 398
            DSE E KK  K+R +K +      + S  ESESES+           E++K+K+K K+E
Sbjct: 118 SDSEDEEKKQGKRRKKKKNRSYKSSQSSTHESESESK-----------ESVKKKKKSKDE 166

Query: 399 EWEKPKDAAGLECK 412
             EK KD   L  K
Sbjct: 167 T-EKEKDVRSLSKK 179



 Score = 39.3 bits (90), Expect = 0.016
 Identities = 27/104 (25%), Positives = 49/104 (47%), Gaps = 6/104 (5%)

Query: 269 EQEEEEEQAGKPGEPSKKEEGRAG--AGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTK 326
           E E E +++ K  + SK E  +      L    +K+   D+       +E+D   D + K
Sbjct: 148 ESESESKESVKKKKKSKDETEKEKDVRSLSKKRKKSYPDDKPLSSESSSESDYEEDVQAK 207

Query: 327 KSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSES 370
           K      + E++E ++++ KK  KK+++KHS       GS  +S
Sbjct: 208 KKR----RCEEREQAKEKVKKKKKKQHKKHSKKKKKKSGSSHKS 247


>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
           [Homo sapiens]
          Length = 916

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 42/146 (28%), Positives = 68/146 (46%), Gaps = 6/146 (4%)

Query: 271 EEEEEQAGKPGEPSKKEEGRAGA----GLGDGERKTNDKDEKKEDGKQAENDSSNDDKTK 326
           EE  E+     E S+ EE          +   E K    +EK+E+ +  E + +      
Sbjct: 454 EEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPV 513

Query: 327 KSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEA 386
           K+     KEE+ E  E+E ++  ++ +     D + + GS  E  SE E G+ EE + EA
Sbjct: 514 KATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEA 573

Query: 387 EALKEKEKPKEEE--WEKPKDAAGLE 410
           EA  E+ + KEE+   EK ++ A  E
Sbjct: 574 EAEGEEAEAKEEKKVEEKSEEVATKE 599



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 40/125 (32%), Positives = 62/125 (49%), Gaps = 9/125 (7%)

Query: 299 ERKTNDKDEKKEDGKQAENDS-SNDDKTKKSEGDGDKEEKKEDSEKE--AKKSSKKRN-- 353
           E K  D+  + E+   A  +  +   K +K E   +KEE+ E  E+E  AKKS  K    
Sbjct: 459 ETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAP 518

Query: 354 --RKHSGDDSFDEGSVSESESE--SESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGL 409
             ++  G+   +EG   E E +  ++S QAEE   E E   EKE+ ++EE E   +A G 
Sbjct: 519 EVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGE 578

Query: 410 ECKPR 414
           E + +
Sbjct: 579 EAEAK 583



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 48/160 (30%), Positives = 75/160 (46%), Gaps = 12/160 (7%)

Query: 258 EGGTENDLRILEQEEEEEQA--GKPGEPSKKEEGRAGAGLGDGERKTND--KDEKKEDGK 313
           EG TE +    E E +EE+    K  E + KEE  A A +   E+  +   K   +E GK
Sbjct: 568 EGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGK 627

Query: 314 QAENDSSNDDKTKKSEGDGDKEEK------KEDSEKEAKKSSKKRNRKHSGDDSFDEGSV 367
                S  ++K K        EEK      K   E++ K    K   +        +  V
Sbjct: 628 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPV 687

Query: 368 SESESESESGQAEEEKEEAEALKE--KEKPKEEEWEKPKD 405
            E++S++E G+ E+++EE + +KE  KE+  E++ EKPKD
Sbjct: 688 EEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKD 727



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 38/147 (25%), Positives = 73/147 (49%), Gaps = 16/147 (10%)

Query: 264 DLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDD 323
           +L +  +EE++E A +  E  + EE    A       K    + K+E+G++ E +   ++
Sbjct: 479 ELAVSMKEEKKEAAEEKEEEPEAEEEEVAA--KKSPVKATAPEVKEEEGEKEEEEGQEEE 536

Query: 324 KTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEK 383
              + E +G K ++ E+   E + SS+K       ++   E   +E+E+E E  +A+EEK
Sbjct: 537 ---EEEDEGAKSDQAEEGGSEKEGSSEK-------EEGEQEEGETEAEAEGEEAEAKEEK 586

Query: 384 EEAEALKE----KEKPKEEEWEKPKDA 406
           +  E  +E    +E   + + EKP+ A
Sbjct: 587 KVEEKSEEVATKEELVADAKVEKPEKA 613



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 41/164 (25%), Positives = 78/164 (47%), Gaps = 18/164 (10%)

Query: 244 DAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTN 303
           +A+  + +   + M+   E      E++EEE +A +    +KK   +A A     E K  
Sbjct: 471 EALTAITEELAVSMK---EEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAP----EVKEE 523

Query: 304 DKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFD 363
           + ++++E+G++ E +     K+ ++E  G   EK+  SEKE  +  +      +      
Sbjct: 524 EGEKEEEEGQEEEEEEDEGAKSDQAEEGGS--EKEGSSEKEEGEQEEGETEAEA------ 575

Query: 364 EGSVSESESESESGQAEEE---KEEAEALKEKEKPKEEEWEKPK 404
           EG  +E++ E +  +  EE   KEE  A  + EKP++ +   PK
Sbjct: 576 EGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPK 619



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 50/166 (30%), Positives = 71/166 (42%), Gaps = 28/166 (16%)

Query: 274 EEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGK----QAENDSSNDDKTKKSE 329
           EE+A  P   S  EE ++ A +G GE+K  ++ E KE  K    + + +   D   KK  
Sbjct: 675 EEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKA 734

Query: 330 GDGDKEEK-----------KEDSEKEAKKSSK-----KRNRKHSGD-DSFDEGS-----V 367
               KEE            K   EKE K+  K     K   K  G+  S +EGS      
Sbjct: 735 ESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKG 794

Query: 368 SESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECKP 413
           S  E  + +G+ E ++E  +  KEK   +EE  EK     GL+  P
Sbjct: 795 SRKEDIAVNGEVEGKEEVEQETKEKGSGREE--EKGVVTNGLDLSP 838



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 39/155 (25%), Positives = 70/155 (45%), Gaps = 12/155 (7%)

Query: 269 EQEEEEEQAGKPGEPSK-------KEEGRAGAGLGDGERKTND---KDEKKEDGKQAEND 318
           E E EEE+      P K       +EEG      G  E +  D   K ++ E+G   +  
Sbjct: 498 EPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEG 557

Query: 319 SSNDDKTKKSEGDGDKEEKKEDSE-KEAKKSSKKRNRKHSGDDSFDEGSVSESESESESG 377
           SS  ++ ++ EG+ + E + E++E KE KK  +K     + ++   +  V + E +++S 
Sbjct: 558 SSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPE-KAKSP 616

Query: 378 QAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECK 412
             +   EE       + P EE+ + P   + +E K
Sbjct: 617 VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEK 651



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 36/159 (22%), Positives = 73/159 (45%), Gaps = 4/159 (2%)

Query: 246 IVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEG--RAGAGLGDGERKTN 303
           +V +  +  + +E  T+ + + L+QE+E+E+AG  GE   +EEG  +   G    +   N
Sbjct: 746 VVTITKSVKVHLEKETKEEGKPLQQEKEKEKAG--GEGGSEEEGSDKGAKGSRKEDIAVN 803

Query: 304 DKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFD 363
            + E KE+ +Q   +  +  + +K       +    D +K   KS +K     + +    
Sbjct: 804 GEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITS 863

Query: 364 EGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEK 402
           EG    ++  ++S    ++ EE E   E++    ++ EK
Sbjct: 864 EGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEK 902



 Score = 34.3 bits (77), Expect = 0.52
 Identities = 43/195 (22%), Positives = 74/195 (37%), Gaps = 24/195 (12%)

Query: 668 KLTPLLSVRESLSEEEAQKM---GRKDPEQEVEKFVTSNTQELGKDKWLCPLSGKKFKGP 724
           K +P+ +    + EEE +K    G+++ E+E E   +   +E G +K     S +K +G 
Sbjct: 509 KKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEK---EGSSEKEEGE 565

Query: 725 --------EFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQIL 776
                   E   +    K  +K+EE  +EVA     + DAK     + K   P  P +  
Sbjct: 566 QEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEK 625

Query: 777 PPGLTPGLPYPH--QTPQGLMPYGQ------PRPPILGYGAGAV--RPAVPTGGPPYPHA 826
                P  P     ++P    P  +      P+ P+   G   V   P       P P +
Sbjct: 626 GKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKS 685

Query: 827 PYGAGRGNYDAFRGQ 841
           P    +   +  +G+
Sbjct: 686 PVEEAKSKAEVGKGE 700


>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
           [Homo sapiens]
          Length = 540

 Score = 55.8 bits (133), Expect = 2e-07
 Identities = 42/146 (28%), Positives = 68/146 (46%), Gaps = 6/146 (4%)

Query: 271 EEEEEQAGKPGEPSKKEEGRAGA----GLGDGERKTNDKDEKKEDGKQAENDSSNDDKTK 326
           EE  E+     E S+ EE          +   E K    +EK+E+ +  E + +      
Sbjct: 78  EEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPV 137

Query: 327 KSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEA 386
           K+     KEE+ E  E+E ++  ++ +     D + + GS  E  SE E G+ EE + EA
Sbjct: 138 KATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEA 197

Query: 387 EALKEKEKPKEEE--WEKPKDAAGLE 410
           EA  E+ + KEE+   EK ++ A  E
Sbjct: 198 EAEGEEAEAKEEKKVEEKSEEVATKE 223



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 40/125 (32%), Positives = 62/125 (49%), Gaps = 9/125 (7%)

Query: 299 ERKTNDKDEKKEDGKQAENDS-SNDDKTKKSEGDGDKEEKKEDSEKE--AKKSSKKRN-- 353
           E K  D+  + E+   A  +  +   K +K E   +KEE+ E  E+E  AKKS  K    
Sbjct: 83  ETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAP 142

Query: 354 --RKHSGDDSFDEGSVSESESE--SESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGL 409
             ++  G+   +EG   E E +  ++S QAEE   E E   EKE+ ++EE E   +A G 
Sbjct: 143 EVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGE 202

Query: 410 ECKPR 414
           E + +
Sbjct: 203 EAEAK 207



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 48/160 (30%), Positives = 75/160 (46%), Gaps = 12/160 (7%)

Query: 258 EGGTENDLRILEQEEEEEQA--GKPGEPSKKEEGRAGAGLGDGERKTND--KDEKKEDGK 313
           EG TE +    E E +EE+    K  E + KEE  A A +   E+  +   K   +E GK
Sbjct: 192 EGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGK 251

Query: 314 QAENDSSNDDKTKKSEGDGDKEEK------KEDSEKEAKKSSKKRNRKHSGDDSFDEGSV 367
                S  ++K K        EEK      K   E++ K    K   +        +  V
Sbjct: 252 SPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPV 311

Query: 368 SESESESESGQAEEEKEEAEALKE--KEKPKEEEWEKPKD 405
            E++S++E G+ E+++EE + +KE  KE+  E++ EKPKD
Sbjct: 312 EEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKD 351



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 38/147 (25%), Positives = 73/147 (49%), Gaps = 16/147 (10%)

Query: 264 DLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDD 323
           +L +  +EE++E A +  E  + EE    A       K    + K+E+G++ E +   ++
Sbjct: 103 ELAVSMKEEKKEAAEEKEEEPEAEEEEVAA--KKSPVKATAPEVKEEEGEKEEEEGQEEE 160

Query: 324 KTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEK 383
              + E +G K ++ E+   E + SS+K       ++   E   +E+E+E E  +A+EEK
Sbjct: 161 ---EEEDEGAKSDQAEEGGSEKEGSSEK-------EEGEQEEGETEAEAEGEEAEAKEEK 210

Query: 384 EEAEALKE----KEKPKEEEWEKPKDA 406
           +  E  +E    +E   + + EKP+ A
Sbjct: 211 KVEEKSEEVATKEELVADAKVEKPEKA 237



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 41/164 (25%), Positives = 78/164 (47%), Gaps = 18/164 (10%)

Query: 244 DAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTN 303
           +A+  + +   + M+   E      E++EEE +A +    +KK   +A A     E K  
Sbjct: 95  EALTAITEELAVSMK---EEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAP----EVKEE 147

Query: 304 DKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFD 363
           + ++++E+G++ E +     K+ ++E  G   EK+  SEKE  +  +      +      
Sbjct: 148 EGEKEEEEGQEEEEEEDEGAKSDQAEEGGS--EKEGSSEKEEGEQEEGETEAEA------ 199

Query: 364 EGSVSESESESESGQAEEE---KEEAEALKEKEKPKEEEWEKPK 404
           EG  +E++ E +  +  EE   KEE  A  + EKP++ +   PK
Sbjct: 200 EGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPK 243



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 50/166 (30%), Positives = 71/166 (42%), Gaps = 28/166 (16%)

Query: 274 EEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGK----QAENDSSNDDKTKKSE 329
           EE+A  P   S  EE ++ A +G GE+K  ++ E KE  K    + + +   D   KK  
Sbjct: 299 EEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKKEEKPKDVPEKKKA 358

Query: 330 GDGDKEEK-----------KEDSEKEAKKSSK-----KRNRKHSGD-DSFDEGS-----V 367
               KEE            K   EKE K+  K     K   K  G+  S +EGS      
Sbjct: 359 ESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGGSEEEGSDKGAKG 418

Query: 368 SESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECKP 413
           S  E  + +G+ E ++E  +  KEK   +EE  EK     GL+  P
Sbjct: 419 SRKEDIAVNGEVEGKEEVEQETKEKGSGREE--EKGVVTNGLDLSP 462



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 39/155 (25%), Positives = 70/155 (45%), Gaps = 12/155 (7%)

Query: 269 EQEEEEEQAGKPGEPSK-------KEEGRAGAGLGDGERKTND---KDEKKEDGKQAEND 318
           E E EEE+      P K       +EEG      G  E +  D   K ++ E+G   +  
Sbjct: 122 EPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEKEG 181

Query: 319 SSNDDKTKKSEGDGDKEEKKEDSE-KEAKKSSKKRNRKHSGDDSFDEGSVSESESESESG 377
           SS  ++ ++ EG+ + E + E++E KE KK  +K     + ++   +  V + E +++S 
Sbjct: 182 SSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPE-KAKSP 240

Query: 378 QAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECK 412
             +   EE       + P EE+ + P   + +E K
Sbjct: 241 VPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEK 275



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 36/159 (22%), Positives = 73/159 (45%), Gaps = 4/159 (2%)

Query: 246 IVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEG--RAGAGLGDGERKTN 303
           +V +  +  + +E  T+ + + L+QE+E+E+AG  GE   +EEG  +   G    +   N
Sbjct: 370 VVTITKSVKVHLEKETKEEGKPLQQEKEKEKAG--GEGGSEEEGSDKGAKGSRKEDIAVN 427

Query: 304 DKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFD 363
            + E KE+ +Q   +  +  + +K       +    D +K   KS +K     + +    
Sbjct: 428 GEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPADEKKGGDKSEEKVVVTKTVEKITS 487

Query: 364 EGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEK 402
           EG    ++  ++S    ++ EE E   E++    ++ EK
Sbjct: 488 EGGDGATKYITKSVTVTQKVEEHEETFEEKLVSTKKVEK 526



 Score = 34.3 bits (77), Expect = 0.52
 Identities = 43/195 (22%), Positives = 74/195 (37%), Gaps = 24/195 (12%)

Query: 668 KLTPLLSVRESLSEEEAQKM---GRKDPEQEVEKFVTSNTQELGKDKWLCPLSGKKFKGP 724
           K +P+ +    + EEE +K    G+++ E+E E   +   +E G +K     S +K +G 
Sbjct: 133 KKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEK---EGSSEKEEGE 189

Query: 725 --------EFVRKHIFNKHAEKIEEVKKEVAFFNNFLTDAKRPALPEIKPAQPPGPAQIL 776
                   E   +    K  +K+EE  +EVA     + DAK     + K   P  P +  
Sbjct: 190 QEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEK 249

Query: 777 PPGLTPGLPYPH--QTPQGLMPYGQ------PRPPILGYGAGAV--RPAVPTGGPPYPHA 826
                P  P     ++P    P  +      P+ P+   G   V   P       P P +
Sbjct: 250 GKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKS 309

Query: 827 PYGAGRGNYDAFRGQ 841
           P    +   +  +G+
Sbjct: 310 PVEEAKSKAEVGKGE 324


>gi|55956788 nucleolin [Homo sapiens]
          Length = 710

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 46/186 (24%), Positives = 79/186 (42%), Gaps = 9/186 (4%)

Query: 256 KMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQA 315
           K +   E D    E EE++E   +  +  +    +A A     E + ++ DE  ED    
Sbjct: 142 KEDSDEEEDDDSEEDEEDDEDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDDDD 201

Query: 316 ENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESE 375
           E D S ++  + +   G K  K    +  AK  ++  + +   +D  D+    + + + E
Sbjct: 202 EEDDSEEEAMETTPAKGKKAAKVVPVK--AKNVAEDEDEEEDDEDEDDDDDEDDEDDDDE 259

Query: 376 SGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECKPRPLHKT-----CSLFMRNIAPN 430
               EEE+EE E    KE P + + E  K  A  E K + +  T      +LF+ N+  N
Sbjct: 260 DD--EEEEEEEEEEPVKEAPGKRKKEMAKQKAAPEAKKQKVEGTEPTTAFNLFVGNLNFN 317

Query: 431 ISRAEI 436
            S  E+
Sbjct: 318 KSAPEL 323



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 36/122 (29%), Positives = 57/122 (46%), Gaps = 7/122 (5%)

Query: 275 EQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDK 334
           ++   PG+      G+ GA +     K N K+ KKED  + E+D S +D+    E D D+
Sbjct: 109 KKGATPGKALVATPGKKGAAIPAKGAK-NGKNAKKEDSDEEEDDDSEEDE----EDDEDE 163

Query: 335 EEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEALKEKEK 394
           +E +++ E  A K++         DD  DE    E + + E   +EEE  E    K K+ 
Sbjct: 164 DEDEDEIEPAAMKAAAAAPASEDEDDEDDED--DEDDDDDEEDDSEEEAMETTPAKGKKA 221

Query: 395 PK 396
            K
Sbjct: 222 AK 223



 Score = 30.0 bits (66), Expect = 9.8
 Identities = 28/120 (23%), Positives = 52/120 (43%), Gaps = 9/120 (7%)

Query: 289 GRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKS 348
           G+ GA  G     T  K       K A+N  +     KK + D   EE+ +DSE++ +  
Sbjct: 108 GKKGATPGKALVATPGKKGAAIPAKGAKNGKN----AKKEDSD---EEEDDDSEEDEEDD 160

Query: 349 SKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAG 408
             +   +   + +  + + +   SE E  + +E+ E+ +   ++E   EEE  +   A G
Sbjct: 161 EDEDEDEDEIEPAAMKAAAAAPASEDEDDEDDEDDEDDD--DDEEDDSEEEAMETTPAKG 218


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 55.5 bits (132), Expect = 2e-07
 Identities = 42/164 (25%), Positives = 74/164 (45%), Gaps = 9/164 (5%)

Query: 251  DAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKE 310
            + A  + EG T+ +  ++E +E EE+A    E  +  E        +GE +   +D    
Sbjct: 1944 EEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDV--- 2000

Query: 311  DGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSES 370
            +  +AE +    ++  + E DG + + K  SE E  +  +   +K  GD   +   V   
Sbjct: 2001 EAPEAEGEMQEAEEEAQPESDGVEAQPK--SEGEEAQEVEGETQKTEGDAQPESDGVEAP 2058

Query: 371  ESESESGQAEEEKEEAEALKEKEK----PKEEEWEKPKDAAGLE 410
            E+E E+ +AE E +EAE     E      +E E E   ++ G+E
Sbjct: 2059 EAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVE 2102



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 38/142 (26%), Positives = 62/142 (43%), Gaps = 9/142 (6%)

Query: 274  EEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGD 333
            +E+ GK    +   E  AG+ LG+ E++     E+ E G Q      N      + GD D
Sbjct: 1770 QEREGK----THNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQD 1825

Query: 334  KEEKKEDSEKEAKKSSKKRNRKHSGDDSFD-EGSVSESES----ESESGQAEEEKEEAEA 388
              +       EA ++  +   +  G ++ + EG   E+E     ESE  +A E + EA+ 
Sbjct: 1826 PGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQP 1885

Query: 389  LKEKEKPKEEEWEKPKDAAGLE 410
              E  +  E EWE   ++ G E
Sbjct: 1886 ESEDVETPEAEWEVQPESEGAE 1907



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 38/164 (23%), Positives = 81/164 (49%), Gaps = 11/164 (6%)

Query: 256  KMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGK-Q 314
            ++EG T+      + E +  +A +  E +++ EG      G+   ++ D D ++ +G+ Q
Sbjct: 2036 EVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQ 2095

Query: 315  AENDSSN----DDKTKKSEG----DGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGS 366
             E++       + + +K+EG    + + E + E    EA ++  +   +  G ++ D  +
Sbjct: 2096 PESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQD--A 2153

Query: 367  VSESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLE 410
              E++ ESE  +A+E +EEA+   E  +  E E E   ++ G+E
Sbjct: 2154 EGEAQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIE 2197



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 30/147 (20%), Positives = 65/147 (44%), Gaps = 1/147 (0%)

Query: 269  EQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKS 328
            E + E E    P    + +    GA   + E++   + E  E  +    D    +  +  
Sbjct: 1882 EAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQ 1941

Query: 329  EGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFD-EGSVSESESESESGQAEEEKEEAE 387
            E +   +E +  ++ E++    +   + +  +S D E    E E++   G+A+ E E+ E
Sbjct: 1942 EAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVE 2001

Query: 388  ALKEKEKPKEEEWEKPKDAAGLECKPR 414
            A + + + +E E E   ++ G+E +P+
Sbjct: 2002 APEAEGEMQEAEEEAQPESDGVEAQPK 2028



 Score = 43.5 bits (101), Expect = 9e-04
 Identities = 44/176 (25%), Positives = 74/176 (42%), Gaps = 14/176 (7%)

Query: 251  DAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGD---GERKTN-DKD 306
            DA   + EG T N       E  E +    G   + E G  G+G  D   GE     D+D
Sbjct: 1766 DAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQD 1825

Query: 307  EKKEDGKQA-ENDSSNDDKTKKSEG------DGDKEEKKEDSEKEAKKSSKKRNRKHSGD 359
              + DG +  E   +  +   +SEG      +GD +E + +++ E++          +  
Sbjct: 1826 PGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQP 1885

Query: 360  DSFDEGSVS---ESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECK 412
            +S D  +     E + ESE  +A E ++EA+   E  +  E E E   ++ G E +
Sbjct: 1886 ESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQ 1941



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 38/164 (23%), Positives = 76/164 (46%), Gaps = 15/164 (9%)

Query: 262  ENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQA----EN 317
            E +++  E+E + E  G   +P  K EG     +    +KT    + + DG +A    E 
Sbjct: 2006 EGEMQEAEEEAQPESDGVEAQP--KSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEE 2063

Query: 318  DSSNDDKTKKSEGDGDKEEKKEDSEK---EAKKSSKKRNRKHS-GDDSFDEG-----SVS 368
                + + +++EG+   E +  D+++   EA+  S+      + G+    EG     +  
Sbjct: 2064 AQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEG 2123

Query: 369  ESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECK 412
            E++ ESE  +A E + EA+   E  + ++ E E   ++ G+E +
Sbjct: 2124 EAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQ 2167



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 31/147 (21%), Positives = 64/147 (43%), Gaps = 4/147 (2%)

Query: 268  LEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKK 327
            +E  E E +A    E  +  E    A   +GE +   +D +  + +      S D +T +
Sbjct: 1835 IEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPE 1894

Query: 328  SEGDGDKEEK---KEDSEKEAKKSSKKRNRKHS-GDDSFDEGSVSESESESESGQAEEEK 383
            +E +   E +     ++EKEA+  ++      + G+D  +       E+E  + +AE + 
Sbjct: 1895 AEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQT 1954

Query: 384  EEAEALKEKEKPKEEEWEKPKDAAGLE 410
            +    + E ++ +EE   + +D   LE
Sbjct: 1955 QPESEVIESQEAEEEAQPESEDVEALE 1981



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 39/186 (20%), Positives = 85/186 (45%), Gaps = 17/186 (9%)

Query: 239  DIDKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRA-----GA 293
            D++  +A  +M +A   + E   E+D    + + E E+A +    ++K EG A     G 
Sbjct: 1999 DVEAPEAEGEMQEA---EEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGV 2055

Query: 294  GLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEE---KKEDSEKEAKKSSK 350
               + E +  + + + ++ +   +  S D   +++EG+   E    +  ++E EA+K+  
Sbjct: 2056 EAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEG 2115

Query: 351  KRNRKHSGDDSFDEGSV------SESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPK 404
                +  G+   +   +       E++ ESE  +A++ + EA+   E  + +E E E   
Sbjct: 2116 IEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQP 2175

Query: 405  DAAGLE 410
            +  G+E
Sbjct: 2176 ELEGVE 2181



 Score = 40.4 bits (93), Expect = 0.007
 Identities = 39/154 (25%), Positives = 69/154 (44%), Gaps = 11/154 (7%)

Query: 269  EQEEEEEQAGKPG---EPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQA----ENDSSN 321
            E +E EE+A       E   K EG     +    +KT    + + DG +A    E     
Sbjct: 2008 EMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEA 2067

Query: 322  DDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSES-ESESESGQAE 380
            + + +++EG+   E +  D++ EA+  ++  +      ++  E   +E  E+    G+A+
Sbjct: 2068 EGEVQEAEGEAHPESEDVDAQ-EAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQ 2126

Query: 381  EEKEEAEALK-EKEKPKEEEWEKPKDAAGLECKP 413
             E E  EA + E E   E E  + +DA G E +P
Sbjct: 2127 PESEGIEAPEAEGEAQPESEGVEAQDAEG-EAQP 2159



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 36/172 (20%), Positives = 78/172 (45%), Gaps = 7/172 (4%)

Query: 238  LDIDKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGD 297
            ++  +A+   +  +  V + EG    +   ++ +E E +A    E  +  E    A   +
Sbjct: 2055 VEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAE 2114

Query: 298  GERKTNDKDEKKEDGKQAENDSSNDDKTKKSEG----DGDKEEKKEDSEKEAKKSSKKRN 353
            G      + E + + +  E   +  +   +SEG    D + E + E    EA+++ ++  
Sbjct: 2115 GIEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEAQ 2174

Query: 354  RKHSGDDSFDEGSVSESESESESGQAEEEKEEAE-ALKEKEKPKEEEWEKPK 404
             +  G ++ +  +  E++ ESE  +A E + EA+  L+  E P+ EE  +P+
Sbjct: 2175 PELEGVEAPE--AEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPE 2224



 Score = 38.9 bits (89), Expect = 0.021
 Identities = 37/162 (22%), Positives = 67/162 (41%), Gaps = 6/162 (3%)

Query: 258  EGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAEN 317
            E   + ++++ E +E  E  G   E  + EE +   GL +   +  +  E + +G+Q E 
Sbjct: 1294 ENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEE 1353

Query: 318  DSSNDDKTKKSEGDGDK----EEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESE 373
                + +    EG  ++    EE KE  E   +  + +   K  G    +EGSV   E  
Sbjct: 1354 AQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLP--EEGSVHGQELS 1411

Query: 374  SESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECKPRP 415
              S    +  +E + ++E+E  +     +P  A G E    P
Sbjct: 1412 EASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTEP 1453



 Score = 37.4 bits (85), Expect = 0.061
 Identities = 33/139 (23%), Positives = 64/139 (46%), Gaps = 9/139 (6%)

Query: 273  EEEQAGKPGEPSKKE-EGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGD 331
            E  +A K  +P  +  E     G  + E +  +  E +E  ++AE  +  + +  +S+ +
Sbjct: 1907 EAPEAEKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQ-E 1965

Query: 332  GDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKE------E 385
             ++E + E  + EA +   +  ++  G+   +   V   E+E E  +AEEE +      E
Sbjct: 1966 AEEEAQPESEDVEALEVEVE-TQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVE 2024

Query: 386  AEALKEKEKPKEEEWEKPK 404
            A+   E E+ +E E E  K
Sbjct: 2025 AQPKSEGEEAQEVEGETQK 2043



 Score = 35.0 bits (79), Expect = 0.30
 Identities = 29/145 (20%), Positives = 66/145 (45%), Gaps = 15/145 (10%)

Query: 268  LEQEEEEEQAGKPGEPSKKEEGRAGA-GLGDGERKTNDKDEKKEDGK-QAENDSSNDDKT 325
            LE E E+E   +  E  + EE    A G    E +  +  E +E+ + ++E+  + + + 
Sbjct: 1925 LETEGEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEV 1984

Query: 326  KKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEE 385
            +  E +G+ + + ED E    +   +   +             E++ ES+  +A+ + E 
Sbjct: 1985 ETQEAEGEAQPESEDVEAPEAEGEMQEAEE-------------EAQPESDGVEAQPKSEG 2031

Query: 386  AEALKEKEKPKEEEWEKPKDAAGLE 410
             EA + + + ++ E +   ++ G+E
Sbjct: 2032 EEAQEVEGETQKTEGDAQPESDGVE 2056



 Score = 33.9 bits (76), Expect = 0.68
 Identities = 41/164 (25%), Positives = 62/164 (37%), Gaps = 14/164 (8%)

Query: 256  KMEGGTENDLRILEQEEEEEQAGKPGEPSKKEE--GRAGAGLGDGERKTNDKDEKKEDGK 313
            K E G + +   LE+ +E E  G+  E ++ EE     G GL +   +  +  E  E G 
Sbjct: 1326 KTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGL 1385

Query: 314  QAEN-DSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESES 372
            Q E  +    ++    EG    +E  E S  + K S +        DD   E     + +
Sbjct: 1386 QGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQE--------DDPVQEEEAGRASA 1437

Query: 373  ESESGQAE---EEKEEAEALKEKEKPKEEEWEKPKDAAGLECKP 413
             +E   AE   E  E    L E +    E     +   GLE  P
Sbjct: 1438 SAEPCPAEGTEEPTEPPSHLSETDPSASERQSGSQLEPGLEKPP 1481



 Score = 33.9 bits (76), Expect = 0.68
 Identities = 30/141 (21%), Positives = 54/141 (38%), Gaps = 26/141 (18%)

Query: 287  EEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAK 346
            +EG  G G    +R   DKD K  + +        + KT  SE     E  + + E E  
Sbjct: 1741 DEGEDGEG---SQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGI 1797

Query: 347  KSSKKRNRKHSGDDSFDEGSVS-----------------------ESESESESGQAEEEK 383
                +   + SG +   +G  +                       E++ ESE  +A E +
Sbjct: 1798 SERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAE 1857

Query: 384  EEAEALKEKEKPKEEEWEKPK 404
             +A+  + + +P+ E+ E P+
Sbjct: 1858 GDAQEAEGEAQPESEDVEAPE 1878



 Score = 30.4 bits (67), Expect = 7.5
 Identities = 32/129 (24%), Positives = 60/129 (46%), Gaps = 11/129 (8%)

Query: 291  AGAGLGDGERKTNDKDEKKEDGKQAEN-DSSNDDKTKKSEGDG---DKEEKKEDSEKEAK 346
            A  GLG G  +    DE  EDG+ ++  +   D K  ++EGD    ++E K  +SE  A 
Sbjct: 1726 AEGGLGPGLSQGPGVDEG-EDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAG 1784

Query: 347  KSSKKRNRKHSG----DDSFDEGSVSESESESESGQ-AEEEKEEAEALKEKEKPKEEEWE 401
                +  ++  G     ++  +GS  E   + E+    +++  +++  +  E P E E E
Sbjct: 1785 SELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAP-EAEGE 1843

Query: 402  KPKDAAGLE 410
               ++ G+E
Sbjct: 1844 AQPESEGVE 1852


>gi|83921609 hypothetical protein LOC127254 [Homo sapiens]
          Length = 1530

 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 47/184 (25%), Positives = 85/184 (46%), Gaps = 26/184 (14%)

Query: 257 MEGGTENDLRILEQEE----EEEQAGKPGEPSKKEEGRAGAGL-GDGERKTNDKDEKKED 311
           +E   EN L+   +E+    EE+Q  K       EEG+A   + G  +   +DK +  + 
Sbjct: 486 LEDDQENTLKYEYEEDFEVDEEKQGEK-----SNEEGQADVQMNGIPQSPLDDKKDNLDP 540

Query: 312 GKQAENDSSNDDKTK---KSEGDGDKEEKKEDSEKEAKKSSKKRNRKHS-GDDSFDEGSV 367
            K++E  S      +   K E DG  E + E+ +++ K +S   +R H    DS DE +V
Sbjct: 541 EKESETSSQKAPDARDNVKDENDGCSESELEEDKQDMKTASSTSSRSHPYSSDSEDESAV 600

Query: 368 SESESESESGQAEE-EKEEAEALKEKEKPKE-----------EEWEKPKDAAGLECKPRP 415
            + E+ ++S   E   +  ++ L E +KP++           E  ++    A +E KP P
Sbjct: 601 GDREAHTDSSTDESARRSSSQELSENDKPRKSHLPIEESLEIEIEDQEITKADVETKPMP 660

Query: 416 LHKT 419
           + ++
Sbjct: 661 IDES 664



 Score = 36.6 bits (83), Expect = 0.10
 Identities = 43/187 (22%), Positives = 71/187 (37%), Gaps = 33/187 (17%)

Query: 247  VKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKPGEP--------SKKEEGRAGAGLGDG 298
            V  L  A    EG  E  + + +  E EE+A    E         SK+E+G   A LG G
Sbjct: 919  VAALREAATSEEGEAEGGVAVSDVGESEEEASIDLEDTGPMEDTASKREDGSEEAILG-G 977

Query: 299  ERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEK---------KEDSEKEAKKSS 349
            E    ++ E      +    +   + ++    +G  EE          KED E E   + 
Sbjct: 978  EEPAKERKEVMRTETRLSPFTGEAEASRMQVSEGSPEEGSLAKEAFLCKEDVEGEEMVTE 1037

Query: 350  KKRNRKHSGDDSFDEG---------------SVSESESESESGQAEEEKEEAEALKEKEK 394
             + NR+    +   +                S+ +++SE E        ++ +A KE++K
Sbjct: 1038 AEANREDDRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQK 1097

Query: 395  PKEEEWE 401
             K EE E
Sbjct: 1098 LKAEEGE 1104



 Score = 32.3 bits (72), Expect = 2.0
 Identities = 42/174 (24%), Positives = 68/174 (39%), Gaps = 21/174 (12%)

Query: 241  DKADAIVKMLDAAVIKMEGGT-ENDLRILEQEEEEEQAGKP--GEPSKKEEGRAGAGLGD 297
            D+ + + K LD A  + +    +  LR  + E EE         E + KEE +  A  G+
Sbjct: 1045 DRKEILPKELDLARERRKAERPKTSLRKTDSEREEVTRANALKDEDAFKEEQKLKAEEGE 1104

Query: 298  GERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEA-----------K 346
             E +   ++E K    +  +D+ N+   + SE   +     EDS KE            +
Sbjct: 1105 TETEVRAEEETKAPPNEMGSDAENEAPVEASELSDNPGLLGEDSLKETVVPIFEATPGFE 1164

Query: 347  KSSKKRN--RKHSGDDSFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEE 398
            KS +     RK  G +      +SE+       + E    E  ALKE  +   E
Sbjct: 1165 KSLENITALRKEGGGE-----RLSEARDTEHKDREELSSRENRALKEGHRQDGE 1213



 Score = 30.8 bits (68), Expect = 5.7
 Identities = 33/151 (21%), Positives = 59/151 (39%), Gaps = 16/151 (10%)

Query: 258  EGGTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAEN 317
            +GG +  LR  E   EE+       P   E+ R        E   ++  E++ED +    
Sbjct: 1261 QGGVDVVLRTQEAVAEED-------PIMAEKFR--------EEAVDEDPEEEEDKECTLE 1305

Query: 318  DSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESG 377
              +  D+  + +GD + E   + +E             H G ++  E +  E E  + S 
Sbjct: 1306 TEAMQDRNSEGDGDMEGEGNTQKNEGMGGGRVVAVEVLHGGGET-AETAAEEREVLAGSE 1364

Query: 378  QAEEEKEEAEALKEKEKPKEEEWEKPKDAAG 408
             AEE+    +A    +  +EE W +  +  G
Sbjct: 1365 TAEEKTIANKASSFSDVAEEETWHQQDELVG 1395


>gi|168229156 NFKB activating protein [Homo sapiens]
          Length = 415

 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 36/127 (28%), Positives = 62/127 (48%), Gaps = 8/127 (6%)

Query: 270 QEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSE 329
           +EE+++++ +  E SKK   +  +     +RK     E  +    +E DSS++D  ++++
Sbjct: 179 EEEKKKKSSRSKERSKKRRKKKSS-----KRKHKKYSEDSDSDSDSETDSSDEDNKRRAK 233

Query: 330 GDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEAEAL 389
               KE+KK+   K+ KK   K++RK S D S  E   S+ E      +   + EE   L
Sbjct: 234 KAKKKEKKKKHRSKKYKKKRSKKSRKESSDSSSKE---SQEEFLENPWKDRTKAEEPSDL 290

Query: 390 KEKEKPK 396
              E PK
Sbjct: 291 IGPEAPK 297



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 45/152 (29%), Positives = 75/152 (49%), Gaps = 17/152 (11%)

Query: 260 GTENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTN---DKDE----KKEDG 312
           G++     L  +E EE   +     ++  G  GA    G    N   D DE    + E+ 
Sbjct: 109 GSDKPWPSLLDKEREESLRQKRLSERERIGELGAPEVWGLSPKNPEPDSDEHTPVEDEEP 168

Query: 313 KQAENDSSNDDKTKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESES 372
           K++   +S  ++ KK +    KE  K+   +  KKSSK++++K+S      E S S+S+S
Sbjct: 169 KKSTTSASTSEEEKKKKSSRSKERSKK---RRKKKSSKRKHKKYS------EDSDSDSDS 219

Query: 373 ESESGQAEEEKEEAEALKEKEKPKEEEWEKPK 404
           E++S   E+ K  A+  K+KEK K+   +K K
Sbjct: 220 ETDSSD-EDNKRRAKKAKKKEKKKKHRSKKYK 250



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 36/144 (25%), Positives = 60/144 (41%), Gaps = 8/144 (5%)

Query: 272 EEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDKTKKSE-- 329
           E +     P E  + ++    A   + E+K      K+   K+ +  SS     K SE  
Sbjct: 154 EPDSDEHTPVEDEEPKKSTTSASTSEEEKKKKSSRSKERSKKRRKKKSSKRKHKKYSEDS 213

Query: 330 ---GDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKEEA 386
               D + +   ED+++ AKK+ KK  +K      + +    +S  ES    ++E +EE 
Sbjct: 214 DSDSDSETDSSDEDNKRRAKKAKKKEKKKKHRSKKYKKKRSKKSRKESSDSSSKESQEEF 273

Query: 387 EALKEKEKPKEEEWEKPKDAAGLE 410
                K++ K EE   P D  G E
Sbjct: 274 LENPWKDRTKAEE---PSDLIGPE 294


>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
           [Homo sapiens]
          Length = 651

 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 56/240 (23%), Positives = 98/240 (40%), Gaps = 30/240 (12%)

Query: 161 DSVDETEAVKRYNDYKLDFRRQQMQDFFLAHKDEEWFRSKYHPDEVGKRRQEARGALQNR 220
           D   +TE+    +    D R+   +D     KD++   +K +P+       +A+ A  + 
Sbjct: 325 DVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDS 384

Query: 221 LRVFLSLMETGWFDNLLLDIDKADAIVKMLDAAVIKMEGGTENDLRILEQEEEEEQAGKP 280
                           L    K D   K  DA  I     +E++L   E +++E++  K 
Sbjct: 385 RN--------------LKKASKNDD--KKKDAKKITFSTDSESELESKESQKDEKKDKKD 428

Query: 281 GEPSKKEEGRAGAGLGDGERKTNDKDEK-KEDGKQAENDSSNDDKTK-------KSEGDG 332
            +   K+  +      D + +     +K K+D K+ + DS  DDK K        +E + 
Sbjct: 429 SKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMES 488

Query: 333 DKEEKKEDSEKEAKKSSKK------RNRKHSGDDSFDEGSVSESESESESGQAEEEKEEA 386
           D E KK+    + KK SKK      R    S D  FDE S +  ++ ++   ++ E EE+
Sbjct: 489 DLELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEES 548



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 32/140 (22%), Positives = 66/140 (47%), Gaps = 2/140 (1%)

Query: 265 LRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSNDDK 324
           LR   Q   +  + K  + +KK+  +      D E  + D  + K+D K+ + +   DDK
Sbjct: 265 LRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAE--SEDSKDAKKDSKKVKKNVKKDDK 322

Query: 325 TKKSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKE 384
            K  + D +  + +    K+ +K +KK  +K   DD   +       +++ESG A++ + 
Sbjct: 323 KKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARN 382

Query: 385 EAEALKEKEKPKEEEWEKPK 404
           ++  LK+  K  +++ +  K
Sbjct: 383 DSRNLKKASKNDDKKKDAKK 402



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 43/163 (26%), Positives = 80/163 (49%), Gaps = 17/163 (10%)

Query: 261 TENDLRILEQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSS 320
           T+ D + L+++++++   K  E +  E G       D +   ND    K   K ++ND  
Sbjct: 347 TKKDKKKLKKDDKKKDTKKYPESTDTESG-------DAKDARNDSRNLK---KASKNDDK 396

Query: 321 NDDKTK-----KSEGDGDKEEKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESE 375
             D  K      SE + + +E ++D EK+ KK SK  N+K   +D     + SE + +S+
Sbjct: 397 KKDAKKITFSTDSESELESKESQKD-EKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSK 455

Query: 376 SGQAEEEKEEAEALK-EKEKPKEEEWEKPKDAAGLECKPRPLH 417
            G+ +E+K + ++ K +K+K  ++  E  +  + LE K    H
Sbjct: 456 KGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKH 498



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 38/148 (25%), Positives = 69/148 (46%), Gaps = 8/148 (5%)

Query: 263 NDLRILEQEEEEEQAGKPGEP---SKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDS 319
           ND R L++  + +   K  +    S   E    +     + K + KD K ++ K  +ND 
Sbjct: 382 NDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDE 441

Query: 320 SNDDKTKKSEGD---GDKEEKK--EDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESES 374
            + D   + +GD   G K+EKK  +DS+K+ KK   K+N + +  +S  E    +  S+ 
Sbjct: 442 ESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKE 501

Query: 375 ESGQAEEEKEEAEALKEKEKPKEEEWEK 402
           + G  ++ K++A    E    + +E  K
Sbjct: 502 KKGSKKDIKKDARKDTESTDAEFDESSK 529



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 38/147 (25%), Positives = 68/147 (46%), Gaps = 26/147 (17%)

Query: 269 EQEEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDS---SNDDKT 325
           E E E +++ K  +  KK+             KT++K   K D +  + DS    +  K 
Sbjct: 410 ESELESKESQKDEKKDKKDS------------KTDNKKSVKNDEESTDADSEPKGDSKKG 457

Query: 326 KKSEGDGDKEEKKEDSEKEAKKSSK----------KRNRKHSGDDSFDEGSV-SESESES 374
           KK E  G K+ KK+D +K+AKK+++          K+++KHS +    +  +  ++  ++
Sbjct: 458 KKDEKKGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKDARKDT 517

Query: 375 ESGQAEEEKEEAEALKEKEKPKEEEWE 401
           ES  AE ++      K   K K  + E
Sbjct: 518 ESTDAEFDESSKTGFKTSTKIKGSDTE 544



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 36/158 (22%), Positives = 75/158 (47%), Gaps = 27/158 (17%)

Query: 271 EEEEEQAGKPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQ------AENDSSNDDK 324
           +++ ++  K    ++ E+ +         +K   KD+KK+D K+      AE+  S D++
Sbjct: 285 KKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDER 344

Query: 325 --TKKSEGDGDKEEKKEDSE-------------KEAKKSSKKRNRKHSGDDSFDE----- 364
             TKK +    K++KK+D++             K+A+  S+   +    DD   +     
Sbjct: 345 KDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKIT 404

Query: 365 -GSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWE 401
             + SESE ES+  Q +E+K++ ++  + +K  + + E
Sbjct: 405 FSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEE 442



 Score = 42.0 bits (97), Expect = 0.002
 Identities = 39/147 (26%), Positives = 63/147 (42%), Gaps = 22/147 (14%)

Query: 279 KPGEPSKKEEGRAGAGLGDGERKTNDKDEKKEDGKQAENDSSN---DDKTKKSEGDGDKE 335
           K  E  K ++ + G  L         KD KK+ G  A N  S    ++KTK+ + + DK 
Sbjct: 111 KKAEYKKSKDEKGGTPL--------KKDSKKKGGSYATNPESKQIVEEKTKR-QNEADKT 161

Query: 336 EKKEDSEKEAKKSSKKRNRKHSGDDSFDEGSVSESESESESGQAEEEKE-EAEALKEKEK 394
             K   E E  K SK  +   +  +S +  +VS++ S+ +   ++  K+   E L  K  
Sbjct: 162 PLKSSHENEQSKKSK--SSSETNPESQNSKTVSKNCSQKDKKDSKNSKKTNTEFLHTKNN 219

Query: 395 PKEEEWEKPKDAAGLECKPRPLHKTCS 421
           PK       KD    +    P+ + CS
Sbjct: 220 PK-------KDLKRSKTSNDPISEICS 239



 Score = 30.0 bits (66), Expect = 9.8
 Identities = 33/143 (23%), Positives = 61/143 (42%), Gaps = 19/143 (13%)

Query: 299 ERKTNDKDEKKEDGKQAENDSSNDDKTKKSEGDGDKEEKK-EDSEKEAKKSSKKRNRKHS 357
           E+K + KD KK+  K  E+  +  D++ K+   G K   K + S+ E+++S  K   K  
Sbjct: 501 EKKGSKKDIKKDARKDTESTDAEFDESSKT---GFKTSTKIKGSDTESEESLYKPGAKKK 557

Query: 358 GDDSFDEGSVSESESESESGQAEEEKEEAEALKEKEKPKEEEWEKPKDAAGLECKPRPLH 417
            D+S  +G+ + S+ E        E +    +  K+    E+ EK         + +P  
Sbjct: 558 IDES--DGTSANSKMEG------LESKRGFRMSSKKTTFNEKGEKASTGRVPPSREKPPL 609

Query: 418 KTCSLFMRNIAPNISRAEIISLC 440
             C        P++   ++  LC
Sbjct: 610 PACE-------PSLPSPKVRRLC 625


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.313    0.135    0.407 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,605,221
Number of Sequences: 37866
Number of extensions: 2709115
Number of successful extensions: 43633
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 749
Number of HSP's successfully gapped in prelim test: 1223
Number of HSP's that attempted gapping in prelim test: 15573
Number of HSP's gapped (non-prelim): 15294
length of query: 875
length of database: 18,247,518
effective HSP length: 111
effective length of query: 764
effective length of database: 14,044,392
effective search space: 10729915488
effective search space used: 10729915488
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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