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Search of human proteins with 191252801
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|191252801 WDFY family member 4 [Homo sapiens]
(3184 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|191252801 WDFY family member 4 [Homo sapiens] 6391 0.0
gi|31317272 WD repeat and FYVE domain containing 3 isoform 1 [Ho... 1796 0.0
gi|54292123 lysosomal trafficking regulator [Homo sapiens] 380 e-104
gi|148233596 LPS-responsive vesicle trafficking, beach and ancho... 341 6e-93
gi|149944548 neurobeachin-like 2 [Homo sapiens] 337 1e-91
gi|224451124 neurobeachin-like 1 isoform 3 [Homo sapiens] 325 4e-88
gi|149944613 neurobeachin-like 1 isoform 1 [Homo sapiens] 325 4e-88
gi|62422577 neurobeachin [Homo sapiens] 324 7e-88
gi|154240744 neurobeachin-like 1 isoform 2 [Homo sapiens] 315 3e-85
gi|31317268 WD repeat and FYVE domain containing 3 isoform 2 [Ho... 298 6e-80
gi|31543297 neutral sphingomyelinase (N-SMase) activation associ... 273 2e-72
gi|221625547 neutral sphingomyelinase (N-SMase) activation assoc... 273 2e-72
gi|239756689 PREDICTED: WD repeat domain 81 [Homo sapiens] 90 4e-17
gi|239751186 PREDICTED: WD repeat domain 81 [Homo sapiens] 90 4e-17
gi|239745674 PREDICTED: WD repeat domain 81 [Homo sapiens] 90 4e-17
gi|31317270 WD repeat and FYVE domain containing 3 isoform 3 [Ho... 55 8e-07
gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [... 54 3e-06
gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [... 53 5e-06
gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [... 52 9e-06
gi|89886480 zinedin isoform 2 [Homo sapiens] 51 2e-05
gi|89886477 zinedin isoform 1 [Homo sapiens] 51 2e-05
gi|23199987 WD repeat domain 5B [Homo sapiens] 51 2e-05
gi|5174447 guanine nucleotide binding protein (G protein), beta ... 50 3e-05
gi|62234461 Notchless gene homolog isoform a [Homo sapiens] 50 4e-05
gi|18874090 WD repeat domain 48 [Homo sapiens] 50 5e-05
gi|4557741 platelet-activating factor acetylhydrolase, isoform I... 49 6e-05
gi|113865883 WD repeat domain 38 [Homo sapiens] 49 6e-05
gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens] 49 6e-05
gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens] 49 6e-05
gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)... 49 8e-05
>gi|191252801 WDFY family member 4 [Homo sapiens]
Length = 3184
Score = 6391 bits (16581), Expect = 0.0
Identities = 3184/3184 (100%), Positives = 3184/3184 (100%)
Query: 1 MEAEDLSKAEDRNEDPGSKNEGQLAAVQPDVPHGGQSSSPTALWDMLERKFLEYQQLTHK 60
MEAEDLSKAEDRNEDPGSKNEGQLAAVQPDVPHGGQSSSPTALWDMLERKFLEYQQLTHK
Sbjct: 1 MEAEDLSKAEDRNEDPGSKNEGQLAAVQPDVPHGGQSSSPTALWDMLERKFLEYQQLTHK 60
Query: 61 SPIERQKSLLSLLPLFLKAWEHSVGIICFPSLQRLAEDVSDQLAQQLQKALVGKPAEQAR 120
SPIERQKSLLSLLPLFLKAWEHSVGIICFPSLQRLAEDVSDQLAQQLQKALVGKPAEQAR
Sbjct: 61 SPIERQKSLLSLLPLFLKAWEHSVGIICFPSLQRLAEDVSDQLAQQLQKALVGKPAEQAR 120
Query: 121 LAAGQLLWWKGDVDQDGYLLLKSVYVLTGTDSETLGRVAESGLPALLLQCLYLFFVFPLD 180
LAAGQLLWWKGDVDQDGYLLLKSVYVLTGTDSETLGRVAESGLPALLLQCLYLFFVFPLD
Sbjct: 121 LAAGQLLWWKGDVDQDGYLLLKSVYVLTGTDSETLGRVAESGLPALLLQCLYLFFVFPLD 180
Query: 181 KDELLESDLQVQKMFVQMLLNICSDSQGLEGLLSGSELQSLLIATTCLREHSCCFWKEPT 240
KDELLESDLQVQKMFVQMLLNICSDSQGLEGLLSGSELQSLLIATTCLREHSCCFWKEPT
Sbjct: 181 KDELLESDLQVQKMFVQMLLNICSDSQGLEGLLSGSELQSLLIATTCLREHSCCFWKEPT 240
Query: 241 FCVLRAISKAQNLSIIQYLQATDCVRLSLQNLSRLTDTLPAPEVSEAVSLILGFVKDSYP 300
FCVLRAISKAQNLSIIQYLQATDCVRLSLQNLSRLTDTLPAPEVSEAVSLILGFVKDSYP
Sbjct: 241 FCVLRAISKAQNLSIIQYLQATDCVRLSLQNLSRLTDTLPAPEVSEAVSLILGFVKDSYP 300
Query: 301 VSSALFLEFENSEGYPLLLKVLLRYDGLTQSEVDPHLEELLGLVVWLTTCGRSELKVFDS 360
VSSALFLEFENSEGYPLLLKVLLRYDGLTQSEVDPHLEELLGLVVWLTTCGRSELKVFDS
Sbjct: 301 VSSALFLEFENSEGYPLLLKVLLRYDGLTQSEVDPHLEELLGLVVWLTTCGRSELKVFDS 360
Query: 361 ITYPQLEGFKFHHEASGVTVKNLQAFQVLQNVFHKASDSVLCIQVLSVIRTMWAWNARNF 420
ITYPQLEGFKFHHEASGVTVKNLQAFQVLQNVFHKASDSVLCIQVLSVIRTMWAWNARNF
Sbjct: 361 ITYPQLEGFKFHHEASGVTVKNLQAFQVLQNVFHKASDSVLCIQVLSVIRTMWAWNARNF 420
Query: 421 FLLEWTLQPISQFVEIMPLKPAPVQEHFFQLLEALVFELHYVPHEILRKVQHLIKESPGP 480
FLLEWTLQPISQFVEIMPLKPAPVQEHFFQLLEALVFELHYVPHEILRKVQHLIKESPGP
Sbjct: 421 FLLEWTLQPISQFVEIMPLKPAPVQEHFFQLLEALVFELHYVPHEILRKVQHLIKESPGP 480
Query: 481 SCTLMALQSILSIAGGDPLFTDIFRDSGLLGLLLAQLRKQAKIMRKSGNKVSTPGVQDPE 540
SCTLMALQSILSIAGGDPLFTDIFRDSGLLGLLLAQLRKQAKIMRKSGNKVSTPGVQDPE
Sbjct: 481 SCTLMALQSILSIAGGDPLFTDIFRDSGLLGLLLAQLRKQAKIMRKSGNKVSTPGVQDPE 540
Query: 541 RELTCVMLRIVVTLLKGSVRNAVVLKDHGMVPFIKIFLDDECYREASLSILEQLSAINAE 600
RELTCVMLRIVVTLLKGSVRNAVVLKDHGMVPFIKIFLDDECYREASLSILEQLSAINAE
Sbjct: 541 RELTCVMLRIVVTLLKGSVRNAVVLKDHGMVPFIKIFLDDECYREASLSILEQLSAINAE 600
Query: 601 EYMSIIVGALCSSTQGELQLKLDLLKSLLRILVTPKGRAAFRVSSGFNGLLSLLSDLEGS 660
EYMSIIVGALCSSTQGELQLKLDLLKSLLRILVTPKGRAAFRVSSGFNGLLSLLSDLEGS
Sbjct: 601 EYMSIIVGALCSSTQGELQLKLDLLKSLLRILVTPKGRAAFRVSSGFNGLLSLLSDLEGS 660
Query: 661 LQEPPLQAWGAVSPRQTLELVLYTLCAVSAALHWDPVNGYFFRRNGLFEKLAEDLCLLGC 720
LQEPPLQAWGAVSPRQTLELVLYTLCAVSAALHWDPVNGYFFRRNGLFEKLAEDLCLLGC
Sbjct: 661 LQEPPLQAWGAVSPRQTLELVLYTLCAVSAALHWDPVNGYFFRRNGLFEKLAEDLCLLGC 720
Query: 721 FGALEEEGNLLRSWVDTKARPFADLLGTAFSSSGSLPPRIQSCLQILGFLDSMASGTLHL 780
FGALEEEGNLLRSWVDTKARPFADLLGTAFSSSGSLPPRIQSCLQILGFLDSMASGTLHL
Sbjct: 721 FGALEEEGNLLRSWVDTKARPFADLLGTAFSSSGSLPPRIQSCLQILGFLDSMASGTLHL 780
Query: 781 RGDLKESLRTKQGPVVDVQKGETGSDPQRNFKQWPDLEERMDEGDAAIMHPGVVCIMVRL 840
RGDLKESLRTKQGPVVDVQKGETGSDPQRNFKQWPDLEERMDEGDAAIMHPGVVCIMVRL
Sbjct: 781 RGDLKESLRTKQGPVVDVQKGETGSDPQRNFKQWPDLEERMDEGDAAIMHPGVVCIMVRL 840
Query: 841 LPRLYHEDHPQLSEEIQCSLASHIQSLVKSEKNRQVMCEAGLLGTLMASCHRALVTSGSP 900
LPRLYHEDHPQLSEEIQCSLASHIQSLVKSEKNRQVMCEAGLLGTLMASCHRALVTSGSP
Sbjct: 841 LPRLYHEDHPQLSEEIQCSLASHIQSLVKSEKNRQVMCEAGLLGTLMASCHRALVTSGSP 900
Query: 901 LHSRLIRIFEKLASQAIEPDVLRQFLGLGIPSSLSATTKILDSSHTHRGNPGCSGSQTAQ 960
LHSRLIRIFEKLASQAIEPDVLRQFLGLGIPSSLSATTKILDSSHTHRGNPGCSGSQTAQ
Sbjct: 901 LHSRLIRIFEKLASQAIEPDVLRQFLGLGIPSSLSATTKILDSSHTHRGNPGCSGSQTAQ 960
Query: 961 GLAEGPWPAAPDAGLHPGVTQAPQPLGESQDSTTALQTALSLISMTSPRNLQPQRAALAP 1020
GLAEGPWPAAPDAGLHPGVTQAPQPLGESQDSTTALQTALSLISMTSPRNLQPQRAALAP
Sbjct: 961 GLAEGPWPAAPDAGLHPGVTQAPQPLGESQDSTTALQTALSLISMTSPRNLQPQRAALAP 1020
Query: 1021 SFVEFDMSVEGYGCLFIPTLSTVMGTSTEYSVSGGIGTGATRPFPPPGGLTFSCWFLISR 1080
SFVEFDMSVEGYGCLFIPTLSTVMGTSTEYSVSGGIGTGATRPFPPPGGLTFSCWFLISR
Sbjct: 1021 SFVEFDMSVEGYGCLFIPTLSTVMGTSTEYSVSGGIGTGATRPFPPPGGLTFSCWFLISR 1080
Query: 1081 HGAATEGHPLRFLTLVRHLARTEQPFVCFSVSLCPDDLSLVVSTEEKEFQPLDVMEPEDD 1140
HGAATEGHPLRFLTLVRHLARTEQPFVCFSVSLCPDDLSLVVSTEEKEFQPLDVMEPEDD
Sbjct: 1081 HGAATEGHPLRFLTLVRHLARTEQPFVCFSVSLCPDDLSLVVSTEEKEFQPLDVMEPEDD 1140
Query: 1141 SEPSAGCQLQVRCGQLLACGQWHHLAVVVTKEMKRHCTVSTCLDGQVIGSAKMLYIQALP 1200
SEPSAGCQLQVRCGQLLACGQWHHLAVVVTKEMKRHCTVSTCLDGQVIGSAKMLYIQALP
Sbjct: 1141 SEPSAGCQLQVRCGQLLACGQWHHLAVVVTKEMKRHCTVSTCLDGQVIGSAKMLYIQALP 1200
Query: 1201 GPFLSMDPSAFVDVYGYIATPRVWKQKSSLIWRLGPTYLFEEAISMETLEVINKLGPRYC 1260
GPFLSMDPSAFVDVYGYIATPRVWKQKSSLIWRLGPTYLFEEAISMETLEVINKLGPRYC
Sbjct: 1201 GPFLSMDPSAFVDVYGYIATPRVWKQKSSLIWRLGPTYLFEEAISMETLEVINKLGPRYC 1260
Query: 1261 GNFQAVHVQGEDLDSEATPFVAEERVSFGLHIASSSITSVADIRNAYNEVDSRLIAKEMN 1320
GNFQAVHVQGEDLDSEATPFVAEERVSFGLHIASSSITSVADIRNAYNEVDSRLIAKEMN
Sbjct: 1261 GNFQAVHVQGEDLDSEATPFVAEERVSFGLHIASSSITSVADIRNAYNEVDSRLIAKEMN 1320
Query: 1321 ISSRDNAMPVFLLRNCAGHLSGSLRTIGAVAVGQLGVRVFHSSPAASSLDFIGGPAILLG 1380
ISSRDNAMPVFLLRNCAGHLSGSLRTIGAVAVGQLGVRVFHSSPAASSLDFIGGPAILLG
Sbjct: 1321 ISSRDNAMPVFLLRNCAGHLSGSLRTIGAVAVGQLGVRVFHSSPAASSLDFIGGPAILLG 1380
Query: 1381 LISLATDDHTMYAAVKVLHSVLTSNAMCDFLMQHICGYQIMAFLLRKKASLLNHRIFQLI 1440
LISLATDDHTMYAAVKVLHSVLTSNAMCDFLMQHICGYQIMAFLLRKKASLLNHRIFQLI
Sbjct: 1381 LISLATDDHTMYAAVKVLHSVLTSNAMCDFLMQHICGYQIMAFLLRKKASLLNHRIFQLI 1440
Query: 1441 LSVAGTVELGFRSSAITNTGVFQHILCNFELWMNTADNLELSLFSHLLEILQSPREGPRN 1500
LSVAGTVELGFRSSAITNTGVFQHILCNFELWMNTADNLELSLFSHLLEILQSPREGPRN
Sbjct: 1441 LSVAGTVELGFRSSAITNTGVFQHILCNFELWMNTADNLELSLFSHLLEILQSPREGPRN 1500
Query: 1501 AEAAHQAQLIPKLIFLFNEPSLIPSKISTIIGILACQLRGHFSTQDLLRIGLFVVYTLKP 1560
AEAAHQAQLIPKLIFLFNEPSLIPSKISTIIGILACQLRGHFSTQDLLRIGLFVVYTLKP
Sbjct: 1501 AEAAHQAQLIPKLIFLFNEPSLIPSKISTIIGILACQLRGHFSTQDLLRIGLFVVYTLKP 1560
Query: 1561 SSVNERQICMDGALDPSLPAGSQTSGKTIWLRNQLLEMLLSVISSPQLHLSSESKEEMFL 1620
SSVNERQICMDGALDPSLPAGSQTSGKTIWLRNQLLEMLLSVISSPQLHLSSESKEEMFL
Sbjct: 1561 SSVNERQICMDGALDPSLPAGSQTSGKTIWLRNQLLEMLLSVISSPQLHLSSESKEEMFL 1620
Query: 1621 KLGPDWFLLLLQGHLHASTTVLALKLLLYFLASPSLRTRFRDGLCAGSWVERSTEGVDIV 1680
KLGPDWFLLLLQGHLHASTTVLALKLLLYFLASPSLRTRFRDGLCAGSWVERSTEGVDIV
Sbjct: 1621 KLGPDWFLLLLQGHLHASTTVLALKLLLYFLASPSLRTRFRDGLCAGSWVERSTEGVDIV 1680
Query: 1681 MDNLKSQSPLPEQSPCLLPGFRVLNDFLAHHVHIPEVYLIVSTFFLQTPLTELMDGPKDS 1740
MDNLKSQSPLPEQSPCLLPGFRVLNDFLAHHVHIPEVYLIVSTFFLQTPLTELMDGPKDS
Sbjct: 1681 MDNLKSQSPLPEQSPCLLPGFRVLNDFLAHHVHIPEVYLIVSTFFLQTPLTELMDGPKDS 1740
Query: 1741 LDAMLQWLLQRHHQEEVLQAGLCTEGALLLLEMLKATMSQPLAGSEDGAWAQTFPASVLQ 1800
LDAMLQWLLQRHHQEEVLQAGLCTEGALLLLEMLKATMSQPLAGSEDGAWAQTFPASVLQ
Sbjct: 1741 LDAMLQWLLQRHHQEEVLQAGLCTEGALLLLEMLKATMSQPLAGSEDGAWAQTFPASVLQ 1800
Query: 1801 FLSLVHRTYPQDPAWRAPEFLQTLAIAAFPLGAQKGVGAESTRNTSSPEAAAEGDSTVEG 1860
FLSLVHRTYPQDPAWRAPEFLQTLAIAAFPLGAQKGVGAESTRNTSSPEAAAEGDSTVEG
Sbjct: 1801 FLSLVHRTYPQDPAWRAPEFLQTLAIAAFPLGAQKGVGAESTRNTSSPEAAAEGDSTVEG 1860
Query: 1861 LQAPTKAHPARRKLREFTQLLLRELLLGASSPKQWLPLEVLLEASPDHATSQQKRDFQSE 1920
LQAPTKAHPARRKLREFTQLLLRELLLGASSPKQWLPLEVLLEASPDHATSQQKRDFQSE
Sbjct: 1861 LQAPTKAHPARRKLREFTQLLLRELLLGASSPKQWLPLEVLLEASPDHATSQQKRDFQSE 1920
Query: 1921 VLLSAMELFHMTSGGDAAMFRDGKEPQPSAEAAAAPSLANISCFTQKLVEKLYSGMFSAD 1980
VLLSAMELFHMTSGGDAAMFRDGKEPQPSAEAAAAPSLANISCFTQKLVEKLYSGMFSAD
Sbjct: 1921 VLLSAMELFHMTSGGDAAMFRDGKEPQPSAEAAAAPSLANISCFTQKLVEKLYSGMFSAD 1980
Query: 1981 PRHILLFILEHIMVVIETASSQRDTVLSTLYSSLNKVILYCLSKPQQSLSECLGLLSILG 2040
PRHILLFILEHIMVVIETASSQRDTVLSTLYSSLNKVILYCLSKPQQSLSECLGLLSILG
Sbjct: 1981 PRHILLFILEHIMVVIETASSQRDTVLSTLYSSLNKVILYCLSKPQQSLSECLGLLSILG 2040
Query: 2041 FLQEHWDVVFATYNSNISFLLCLMHCLLLLNERSYPEGFGLEPKPRMSTYHQVFLSPNED 2100
FLQEHWDVVFATYNSNISFLLCLMHCLLLLNERSYPEGFGLEPKPRMSTYHQVFLSPNED
Sbjct: 2041 FLQEHWDVVFATYNSNISFLLCLMHCLLLLNERSYPEGFGLEPKPRMSTYHQVFLSPNED 2100
Query: 2101 VKEKREDLPSLSDVQHNIQKTVQTLWQQLVAQRQQTLEDAFKIDLSVKPGEREVKIEEVT 2160
VKEKREDLPSLSDVQHNIQKTVQTLWQQLVAQRQQTLEDAFKIDLSVKPGEREVKIEEVT
Sbjct: 2101 VKEKREDLPSLSDVQHNIQKTVQTLWQQLVAQRQQTLEDAFKIDLSVKPGEREVKIEEVT 2160
Query: 2161 PLWEETMLKAWQHYLASEKKSLASRSNVAHHSKVTLWSGSLSSAMKLMPGRQAKDPECKT 2220
PLWEETMLKAWQHYLASEKKSLASRSNVAHHSKVTLWSGSLSSAMKLMPGRQAKDPECKT
Sbjct: 2161 PLWEETMLKAWQHYLASEKKSLASRSNVAHHSKVTLWSGSLSSAMKLMPGRQAKDPECKT 2220
Query: 2221 EDFVSCIENYRRRGQELYASLYKDHVQRRKCGNIKAANAWARIQEQLFGELGLWSQGEET 2280
EDFVSCIENYRRRGQELYASLYKDHVQRRKCGNIKAANAWARIQEQLFGELGLWSQGEET
Sbjct: 2221 EDFVSCIENYRRRGQELYASLYKDHVQRRKCGNIKAANAWARIQEQLFGELGLWSQGEET 2280
Query: 2281 KPCSPWELDWREGPARMRKRIKRLSPLEALSSGRHKESQDKNDHISQTNAENQDELTLRE 2340
KPCSPWELDWREGPARMRKRIKRLSPLEALSSGRHKESQDKNDHISQTNAENQDELTLRE
Sbjct: 2281 KPCSPWELDWREGPARMRKRIKRLSPLEALSSGRHKESQDKNDHISQTNAENQDELTLRE 2340
Query: 2341 AEGEPDEVGVDCTQLTFFPALHESLHSEDFLELCRERQVILQELLDKEKVTQKFSLVIVQ 2400
AEGEPDEVGVDCTQLTFFPALHESLHSEDFLELCRERQVILQELLDKEKVTQKFSLVIVQ
Sbjct: 2341 AEGEPDEVGVDCTQLTFFPALHESLHSEDFLELCRERQVILQELLDKEKVTQKFSLVIVQ 2400
Query: 2401 GHLVSEGVLLFGHQHFYICENFTLSPTGDVYCTRHCLSNISDPFIFNLCSKDRSTDHYSC 2460
GHLVSEGVLLFGHQHFYICENFTLSPTGDVYCTRHCLSNISDPFIFNLCSKDRSTDHYSC
Sbjct: 2401 GHLVSEGVLLFGHQHFYICENFTLSPTGDVYCTRHCLSNISDPFIFNLCSKDRSTDHYSC 2460
Query: 2461 QCHSYADMRELRQARFLLQDIALEIFFHNGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKA 2520
QCHSYADMRELRQARFLLQDIALEIFFHNGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKA
Sbjct: 2461 QCHSYADMRELRQARFLLQDIALEIFFHNGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKA 2520
Query: 2521 TSEDTLSLRRYPGSDRIMLQKWQKRDISNFEYLMYLNTAAGRTCNDYMQYPVFPWVLADY 2580
TSEDTLSLRRYPGSDRIMLQKWQKRDISNFEYLMYLNTAAGRTCNDYMQYPVFPWVLADY
Sbjct: 2521 TSEDTLSLRRYPGSDRIMLQKWQKRDISNFEYLMYLNTAAGRTCNDYMQYPVFPWVLADY 2580
Query: 2581 TSETLNLANPKIFRDLSKPMGAQTKERKLKFIQRFKEVEKTEGDMTVQCHYYTHYSSAII 2640
TSETLNLANPKIFRDLSKPMGAQTKERKLKFIQRFKEVEKTEGDMTVQCHYYTHYSSAII
Sbjct: 2581 TSETLNLANPKIFRDLSKPMGAQTKERKLKFIQRFKEVEKTEGDMTVQCHYYTHYSSAII 2640
Query: 2641 VASYLVRMPPFTQAFCALQGGSFDVADRMFHSVKSTWESASRENMSDVRELTPEFFYLPE 2700
VASYLVRMPPFTQAFCALQGGSFDVADRMFHSVKSTWESASRENMSDVRELTPEFFYLPE
Sbjct: 2641 VASYLVRMPPFTQAFCALQGGSFDVADRMFHSVKSTWESASRENMSDVRELTPEFFYLPE 2700
Query: 2701 FLTNCNGVEFGCMQDGTVLGDVQLPPWADGDPRKFISLHRKALESDFVSANLHHWIDLIF 2760
FLTNCNGVEFGCMQDGTVLGDVQLPPWADGDPRKFISLHRKALESDFVSANLHHWIDLIF
Sbjct: 2701 FLTNCNGVEFGCMQDGTVLGDVQLPPWADGDPRKFISLHRKALESDFVSANLHHWIDLIF 2760
Query: 2761 GYKQQGPAAVDAVNIFHPYFYGDRMDLSSITDPLIKSTILGFVSNFGQVPKQLFTKPHPA 2820
GYKQQGPAAVDAVNIFHPYFYGDRMDLSSITDPLIKSTILGFVSNFGQVPKQLFTKPHPA
Sbjct: 2761 GYKQQGPAAVDAVNIFHPYFYGDRMDLSSITDPLIKSTILGFVSNFGQVPKQLFTKPHPA 2820
Query: 2821 RTAAGKPLPGKDVSTPVSLPGHPQPFFYSLQSLRPSQVTVKDMYLFSLGSESPKGAIGHI 2880
RTAAGKPLPGKDVSTPVSLPGHPQPFFYSLQSLRPSQVTVKDMYLFSLGSESPKGAIGHI
Sbjct: 2821 RTAAGKPLPGKDVSTPVSLPGHPQPFFYSLQSLRPSQVTVKDMYLFSLGSESPKGAIGHI 2880
Query: 2881 VSTEKTILAVERNKVLLPPLWNRTFSWGFDDFSCCLGSYGSDKVLMTFENLAAWGRCLCA 2940
VSTEKTILAVERNKVLLPPLWNRTFSWGFDDFSCCLGSYGSDKVLMTFENLAAWGRCLCA
Sbjct: 2881 VSTEKTILAVERNKVLLPPLWNRTFSWGFDDFSCCLGSYGSDKVLMTFENLAAWGRCLCA 2940
Query: 2941 VCPSPTTIVTSGTSTVVCVWELSMTKGRPRGLRLRQALYGHTQAVTCLAASVTFSLLVSG 3000
VCPSPTTIVTSGTSTVVCVWELSMTKGRPRGLRLRQALYGHTQAVTCLAASVTFSLLVSG
Sbjct: 2941 VCPSPTTIVTSGTSTVVCVWELSMTKGRPRGLRLRQALYGHTQAVTCLAASVTFSLLVSG 3000
Query: 3001 SQDCTCILWDLDHLTHVTRLPAHREGISAITISDVSGTIVSCAGAHLSLWNVNGQPLASI 3060
SQDCTCILWDLDHLTHVTRLPAHREGISAITISDVSGTIVSCAGAHLSLWNVNGQPLASI
Sbjct: 3001 SQDCTCILWDLDHLTHVTRLPAHREGISAITISDVSGTIVSCAGAHLSLWNVNGQPLASI 3060
Query: 3061 TTAWGPEGAITCCCLMEGPAWDTSQIIITGSQDGMVRVWKTEDVKMSVPGRPAGEEPPAQ 3120
TTAWGPEGAITCCCLMEGPAWDTSQIIITGSQDGMVRVWKTEDVKMSVPGRPAGEEPPAQ
Sbjct: 3061 TTAWGPEGAITCCCLMEGPAWDTSQIIITGSQDGMVRVWKTEDVKMSVPGRPAGEEPPAQ 3120
Query: 3121 PPSPRGHKWEKNLALSRELDVSIALTGKPSKTSPAVTALAVSRNHTKLLVGDERGRIFCW 3180
PPSPRGHKWEKNLALSRELDVSIALTGKPSKTSPAVTALAVSRNHTKLLVGDERGRIFCW
Sbjct: 3121 PPSPRGHKWEKNLALSRELDVSIALTGKPSKTSPAVTALAVSRNHTKLLVGDERGRIFCW 3180
Query: 3181 SADG 3184
SADG
Sbjct: 3181 SADG 3184
>gi|31317272 WD repeat and FYVE domain containing 3 isoform 1 [Homo
sapiens]
Length = 3526
Score = 1796 bits (4651), Expect = 0.0
Identities = 1130/3269 (34%), Positives = 1769/3269 (54%), Gaps = 263/3269 (8%)
Query: 59 HKSPIERQKSLLSLLPLFLKAWEHSVGIIC---FPSLQRLAEDVSDQLAQQLQKALVGKP 115
H + E+++ L +LP+F + + ++ F L + VS + ++++ K
Sbjct: 41 HMTQKEQEEKLYMMLPVFNRVFGNAPPNTMTEKFSDLLQFTTQVSRLMVTEIRRRASNKS 100
Query: 116 AEQARLAAGQLLWWKGDVDQD-----GYLLLKSVYVLTGTDSETLGRVAESGLPALLLQC 170
E A A Q L +++Q G++LL ++ +L + +T+ + +P+ L++C
Sbjct: 101 TEAASRAIVQFL----EINQSEEASRGWMLLTTINLLASSGQKTVDCMTTMSVPSTLVKC 156
Query: 171 LYLFFVFP---------LDKDELLESDLQVQKMFVQMLLNICSDSQGLEGLLSGSELQSL 221
LYLFF P ++ L E +QK+FVQ+L+ +CS E L +LQ L
Sbjct: 157 LYLFFDLPHVPEAVGGAQNELPLAERRGLLQKVFVQILVKLCSFVSPAEELAQKDDLQLL 216
Query: 222 LIATTCLREHSCCFWKEPTFCVLRAISK-AQNLSIIQYLQATDCVRLSLQNLSRLTDTLP 280
A T W++ VL IS+ ++++++Y+ +C+ +QN+ + D P
Sbjct: 217 FSAITSWCPPYNLPWRKSAGEVLMTISRHGLSVNVVKYIHEKECLSTCVQNMQQSDDLSP 276
Query: 281 APEVSEAVSLILGFVKDSYPVSSALFLEFENSEGYPLLLKVLLRYDGLTQSEVDPHLEEL 340
E+ E + + F+KDS VS L +F +GY L +LLR + ++E L++L
Sbjct: 277 L-EIVEMFAGLSCFLKDSSDVSQTLLDDFRIWQGYNFLCDLLLRLEQAKEAESKDALKDL 335
Query: 341 LGLVVWLTTCGRSELKVFDSITYPQ--LEGFKFHHEAS-GVTVKNLQAFQVLQNVFHKAS 397
+ L+ LTT G SELK T L GF A G +V+N+QAF VLQN F KA
Sbjct: 336 VNLITSLTTYGVSELKPAGITTGAPFLLPGFAVPQPAGKGHSVRNVQAFAVLQNAFLKAK 395
Query: 398 DSVLCIQVLSVIRTMWAWNARNFFLLEWTLQPISQFVEIMPLKPAPVQEHFFQLLEALVF 457
S L +L I ++ + N+F+LE + +SQF E + P VQ +F++LE +VF
Sbjct: 396 TSFLAQIILDAITNIYMADNANYFILE-SQHTLSQFAEKISKLPE-VQNKYFEMLEFVVF 453
Query: 458 ELHYVPHEILRKVQHLIKESPGPSCTLMALQSILSIAGGDPLFTDIFRDSGLLGLLLAQL 517
L+Y+P + L V L+K S C+++A++++L D +F D+FR+ GLL +++ L
Sbjct: 454 SLNYIPCKELISVSILLKSSSSYHCSIIAMKTLLKFTRHDYIFKDVFREVGLLEVMVNLL 513
Query: 518 RKQAKIMR-------KSGNKVSTPGVQDPERELTCVMLRIVVTLLKGSVRNAVVLKDHGM 570
K A +++ + G+ + V+D ++ L +++ + LL+GS NA + ++ G
Sbjct: 514 HKYAALLKDPTQALNEQGDSRNNSSVED-QKHLALLVMETLTVLLQGSNTNAGIFREFGG 572
Query: 571 VPFI-KIFLDDECYREASLSILEQLSAINAEEYMSIIVGALCSSTQGELQLKLDLLKSLL 629
I +C + A ++I + + + N ++ M ++G + S+ ELQLK D+L++LL
Sbjct: 573 ARCAHNIVKYPQCRQHALMTIQQLVLSPNGDDDMGTLLGLMHSAPPTELQLKTDILRALL 632
Query: 630 RIL-VTPKGRAAFRVSSGFNGLLSLLSDLEGSLQEPPLQAWGAVSPRQTLELVLYTLCAV 688
+L + + R FR GF + SLL +E SL PP W V+ Q EL+ C +
Sbjct: 633 SVLRESHRSRTVFRKVGGFVYITSLLVAMERSLSCPPKNGWEKVNQNQVFELLHTVFCTL 692
Query: 689 SAALHWDPVNGYFFRRNGLFEKLAEDLCLLGCFGALEEEGNLLRSWVDTKARPFADLLGT 748
+AA+ ++P N +FF+ +EKLA+ + LGCF L + + + + +PF LL
Sbjct: 693 TAAMRYEPANSHFFKTEIQYEKLADAVRFLGCFSDLRKISAM--NVFPSNTQPFQRLLEE 750
Query: 749 AFSSSGSLPPRIQSCLQILGFLDSMASGTLHLRGDL-------KESLRTKQGPVVDVQKG 801
S S+ P ++ C ++ +L +A+ + R + + SL + G +K
Sbjct: 751 DVISIESVSPTLRHCSKLFIYLYKVATDSFDSRAEQIPPCLTSESSLPSPWGTPALSRKR 810
Query: 802 ET----GSDPQRNFKQWPDLE-----ERMDEGDAAIMHPGVVCIMVRLLPRLYHEDHPQL 852
+ P K DL+ + DA I+HPG + M+ LL + P+
Sbjct: 811 HAYHSVSTPPVYPPKNVADLKLHVTTSSLQSSDAVIIHPGAMLAMLDLLASVGSVTQPEH 870
Query: 853 SEEIQCSLASHIQSLVKSEKNRQVMCEAGLLGTLMASCHRALVTSGSPLHSRLIRIFEKL 912
+ ++Q ++A+ +QSLV +E+N+QVMCEAGL L+ C AL LH L R+FE+L
Sbjct: 871 ALDLQLAVANILQSLVHTERNQQVMCEAGLHARLLQRCSAALADEDHSLHPPLQRMFERL 930
Query: 913 ASQAIEPDVLRQFLGLGIPSSLSA-TTKILDSSHTHRGNPGCSGSQTAQGLAEGPWPAAP 971
ASQA+EP VLR+FL L P + A K+L H+ + + +
Sbjct: 931 ASQALEPMVLREFLRLASPLNCGAWDKKLLKQYRVHKPSSLSYEPEMRSSMITSLEGLGT 990
Query: 972 D--AGLHPG--VTQAPQPLGESQDSTTALQTALSLISMTSPRNLQPQRAALAPSFVEFDM 1027
D LH + + ++ ST L L+SMT+P +++ +++ P+FVEFD
Sbjct: 991 DNVFSLHEDNHYRISKSLVKSAEGSTVPLTRVKCLVSMTTPHDIRLHGSSVTPAFVEFDT 1050
Query: 1028 SVEGYGCLFIPTL--------STVMGTSTEYSVSGGIGTGATRPFPPPGGLTFSCWFLIS 1079
S+EG+GCLF+P+L +TV + +V GIG+G R FPPP GL++S WF I
Sbjct: 1051 SLEGFGCLFLPSLAPHNAPTNNTVTTGLIDGAVVSGIGSG-ERFFPPPSGLSYSSWFCIE 1109
Query: 1080 RHGAATEGHPLRFLTLVRHLARTEQPFVCFSVSLCPDDLSLVVSTEEKEFQP-LDVMEPE 1138
+ HP+R LT+VR +EQ +VC ++ L D SL+VST+E+ Q +D E
Sbjct: 1110 HFSSPPNNHPVRLLTVVRRANSSEQHYVCLAIVLSAKDRSLIVSTKEELLQNYVDDFSEE 1169
Query: 1139 DDSEPSAGCQLQVRCGQLLACGQWHHLAVVVTKEMKRHCTVSTCLDGQVIGSAKMLYIQA 1198
C + RCG+L+ GQWHHL +V++K M ++ T + +DGQ++ + K+ Y+ +
Sbjct: 1170 SSFYEILPCCARFRCGELIIEGQWHHLVLVMSKGMLKNSTAALYIDGQLVNTVKLHYVHS 1229
Query: 1199 LPGPFLSMDPSAFVDVYGYIATPRVWKQKSSLIWRLGPTYLFEEAISMETLEVINKLGPR 1258
PG S +P VY YI TP +Q +SL+WRLGPT+ EE + + I +LGP
Sbjct: 1230 TPGGSGSANPPVVSTVYAYIGTPPAQRQIASLVWRLGPTHFLEEVLPSSNVTTIYELGPN 1289
Query: 1259 YCGNFQAVHVQGEDLDSEA-----TPFVAEERVSFGLHIASSSITSVADIRNAYNEVDSR 1313
Y G+FQAV + +D SE V EE+VSFGL+ S S +VA IR YN++DS+
Sbjct: 1290 YVGSFQAVCMPCKDAKSEGVVPSPVSLVPEEKVSFGLYALSVSSLTVARIRKVYNKLDSK 1349
Query: 1314 LIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIGAVAVGQLGVRVFHSSPAASSLDFIG 1373
IAK++ ISS +NA PV L+ N AGHL+GS RTIGA +G LGVR F P A++L ++G
Sbjct: 1350 AIAKQLGISSHENATPVKLIHNSAGHLNGSARTIGAALIGYLGVRTFVPKPVATTLQYVG 1409
Query: 1374 GPAILLGLISLATDDHTMYAAVKVLHSVLTSNAMCDFLMQHICGYQIMAFLLRKKASLLN 1433
G A +LGL+++A+D +YAAVK L V+ SN + M+ I GYQ++A LL+KK SLLN
Sbjct: 1410 GAAAILGLVAMASDVEGLYAAVKALVCVVKSNPLASKEMERIKGYQLLAMLLKKKRSLLN 1469
Query: 1434 HRIFQLILSVAGTVELGFRSSAITNTGVFQHILCNFELWMNTADNLELSLFSHLLEILQS 1493
I L S+ GTV+ G +S I N+ FQ +LC+FE+W++ L LSLF H +E+L
Sbjct: 1470 SHILHLTFSLVGTVDSGHETSIIPNSTAFQDLLCDFEVWLHAPYELHLSLFEHFIELLTE 1529
Query: 1494 PREGPRNAEAAHQAQLIPKLIFLFNEPSLIPSKISTIIGILACQLRGHFSTQDLLRIGLF 1553
E +NA+ + QLIPKL+ + SL I+ I +L+ L+G S+ DLLR G F
Sbjct: 1530 SSEASKNAKLMREFQLIPKLLLTLRDMSLSQPTIAAISNVLSFLLQGFPSSNDLLRFGQF 1589
Query: 1554 VVYTLKPSSVNERQICMDGALDPSLPAGSQ------TSGKTIWLRNQLLEMLLSVI--SS 1605
+ TL +V E+ + M+ + L G++ S I LRN+LL++LL +I S
Sbjct: 1590 ISSTLPTFAVCEKFVVMEINNEEKLDTGTEEEFGGLVSANLILLRNRLLDILLKLIYTSK 1649
Query: 1606 PQLHLSSESKEEMFLKLGPDWFLLLLQGHLHASTTVLALKLLLYFLASPSLRTRFRDGLC 1665
+ ++ ++ EE+ LG DW ++ ++ HLH++T A+++L+ L++ S+ +F++GL
Sbjct: 1650 EKTSINLQACEELVKTLGFDWIMMFMEEHLHSTTVTAAMRILVVLLSNQSILIKFKEGLS 1709
Query: 1666 AGSWVERS----TEGVDIVMD-----NLKSQSPLPE--QSPCLLPGFRVLNDFLAHHVHI 1714
G W+E++ T + V+ + +S + E + C PGF VL FL H ++
Sbjct: 1710 GGGWLEQTDSVLTNKIGTVLGFNVGRSAGGRSTVREINRDACHFPGFPVLQSFLPKHTNV 1769
Query: 1715 PEVYLIVSTFFLQTPLTELMD---------------GPKDSLDAMLQWLLQRHHQEEVLQ 1759
P +Y ++ FLQ P++EL + G + LD++ ++ +
Sbjct: 1770 PALYFLLMALFLQQPVSELPENLQVSVPVISCRSKQGCQFDLDSIWTFIFGVPASSGTVV 1829
Query: 1760 AGL---CTEGALLLLEMLKATMSQPLAGSEDGAWAQTFPASVLQFLSLVHRTYPQ-DPAW 1815
+ + CTE LLL ML++ ++ P E+G+W + +P +++QF ++ P W
Sbjct: 1830 SSIHNVCTEAVFLLLGMLRSMLTSPWQSEEEGSWLREYPVTLMQFFRYLYHNVPDLASMW 1889
Query: 1816 RAPEFLQTLAIAAFPLGAQ--------------------KGVGAESTRNTSSPEAAAEGD 1855
+P+FL LA FP + K A++ N S E G
Sbjct: 1890 MSPDFLCALAATVFPFNIRPYSEMVTDLDDEVGSPAEEFKAFAADTGMNRSQSEYCNVGT 1949
Query: 1856 STVEGLQAPTKAHPARRKLREFTQLLLRELLLGASSPKQWLPLEVLLEASPDHATSQQKR 1915
T HPA++ + +F ++L+ + L + KQ +++LLEASP+ +T Q++
Sbjct: 1950 KTY------LTNHPAKKFVFDFMRVLIIDNLCLTPASKQTPLIDLLLEASPERSTRTQQK 2003
Query: 1916 DFQSEVLLSAMELFHMTSGGDAAMFRDGKEPQPSAEAAAAPSLANISCFTQKLVEKLYSG 1975
+FQ+ +L S M+ H+ + D + D P S + + N+ FTQ++V+KL+ G
Sbjct: 2004 EFQTYILDSVMD--HLLA-ADVLLGEDASLPITSG-GSYQVLVNNVFYFTQRVVDKLWQG 2059
Query: 1976 MFSADPRHILLFILEHIMVVIETASSQRDTVLSTLYSSLNKVILYCLSKPQQSLSECLGL 2035
MF+ + + ++ FI I ++ ++ + L +Y LN+ ILY S+ +++ + + L
Sbjct: 2060 MFNKESKLLIDFI---IQLIAQSKRRSQGLSLDAVYHCLNRTILYQFSRAHKTVPQQVAL 2116
Query: 2036 LSILGFLQEHWDVVFATYNSNISFLLCLMHCLLLLNERSYPEGFGLEPKPRMSTYHQVFL 2095
L L L + +++ N + F+ CL HCL+ L+ S +GFGLE + RM+T+H +
Sbjct: 2117 LDSLRVLTVNRNLILGPGNHDQEFISCLAHCLINLHVGSNVDGFGLEAEARMTTWHIMIP 2176
Query: 2096 SPNEDVKEKREDLPSLSDVQHNIQKTVQTLWQQLVAQRQQTLEDAFKIDLSVKPGEREVK 2155
S D++ +S+ + + K V +W +L+ ++Q LE+ FK+ L V V
Sbjct: 2177 S---DIEPDGSYSQDISEGRQLLIKAVNRVWTELIHSKKQVLEELFKVTLPVNE-RGHVD 2232
Query: 2156 IEEVTPLWEETMLKAWQHYLASEKKSLASRSNVAHHSKVTLWSGSLSSAMKLMPGRQAKD 2215
I PL EE LK WQ++LA EKK ++ +A ++ L S + + G +
Sbjct: 2233 IATARPLIEEAALKCWQNHLAHEKKCISRGEALAPTTQSKLSRVSSGFGLSKLTGSRRNR 2292
Query: 2216 PE-------CKTEDFVSCIENYRRRGQELYASLYKDHVQRRKCGNIKAANAWARIQEQLF 2268
E T++ + + ++L + YK++ +R++ W +I+ +L
Sbjct: 2293 KESGLNKHSLSTQEISQWMFTHIAVVRDLVDTQYKEYQERQQNALKYVTEEWCQIECELL 2352
Query: 2269 GELGLWSQGEETKPCSPWELDWREGPARMRKRIKR-------------LSPLEALSSGRH 2315
E GLW + W L+ EGP RMRK++ R ++S
Sbjct: 2353 RERGLWGPPIGSH-LDKWMLEMTEGPCRMRKKMVRNDMFYNHYPYVPETEQETNVASEIP 2411
Query: 2316 KESQDKNDHISQTN--------AENQDELTLREAEGEPDEVGVDCTQLTFFPAL-HESLH 2366
+ + D I Q + + E +R A G P V + + A E H
Sbjct: 2412 SKQPETPDDIPQKKPARYRRAVSYDSKEYYMRLASGNPAIVQDAIVESSEGEAAQQEPEH 2471
Query: 2367 SEDFLELCR-------------------ERQVILQE------LLDKEKVTQKFSLVIVQG 2401
ED + + E Q LQ+ +++E+ T +L+
Sbjct: 2472 GEDTIAKVKGLVKPPLKRSRSAPDGGDEENQEQLQDQIAEGSSIEEEEKTDNATLL---- 2527
Query: 2402 HLVSEGVLLFGHQHFYIC-----------------------ENFTLSPTGDVYCTRHCLS 2438
L+ EG + QH Y C + FT++ T ++
Sbjct: 2528 RLLEEGEKI---QHMYRCARVQGLDTSEGLLLFGKEHFYVIDGFTMTATREIRDIETLPP 2584
Query: 2439 NISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFHNGYSKFLVFY 2498
N+ +P I + S +C +Y D++E+ + R+LLQ IA+E+F +G + L F
Sbjct: 2585 NMHEPIIPRGARQGPSQLKRTCSIFAYEDIKEVHKRRYLLQPIAVEVFSGDGRNYLLAFQ 2644
Query: 2499 NNDRSKAFKSFCSFQPSLKGKATS----EDTLSLRRYPG------SDRIMLQKWQKRDIS 2548
R+K ++ F + PSL + S S+ + G ++ + Q+W++ +IS
Sbjct: 2645 KGIRNKVYQRFLAVVPSLTDSSESVSGQRPNTSVEQGSGLLSTLVGEKSVTQRWERGEIS 2704
Query: 2549 NFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERK 2608
NF+YLM+LNT AGR+ ND MQYPVFPW+LADY SE ++L NPK FR+L+KPMGAQT ER
Sbjct: 2705 NFQYLMHLNTLAGRSYNDLMQYPVFPWILADYDSEEVDLTNPKTFRNLAKPMGAQTDERL 2764
Query: 2609 LKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADR 2668
++ +R+K+ E G+ T HY THYSSA+IVASYLVRM PFTQ F LQGG FD+ADR
Sbjct: 2765 AQYKKRYKDWEDPNGE-TPAYHYGTHYSSAMIVASYLVRMEPFTQIFLRLQGGHFDLADR 2823
Query: 2669 MFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWA 2728
MFHSV+ W SAS+ NM+DV+EL PEFFYLPEFL N N + GC Q+GT LGDV LPPWA
Sbjct: 2824 MFHSVREAWYSASKHNMADVKELIPEFFYLPEFLFNSNNFDLGCKQNGTKLGDVILPPWA 2883
Query: 2729 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS 2788
GDPR+FI +HR+ALE D+VSA+LH WIDLIFGYKQQGPAAV+AVN+FH FY ++D+
Sbjct: 2884 KGDPREFIRVHREALECDYVSAHLHEWIDLIFGYKQQGPAAVEAVNVFHHLFYEGQVDIY 2943
Query: 2789 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQP--F 2846
+I DPL ++ +GF++NFGQ+PKQLF KPHP + + L G + V LPG F
Sbjct: 2944 NINDPLKETATIGFINNFGQIPKQLFKKPHPPKRVRSR-LNGDNAGISV-LPGSTSDKIF 3001
Query: 2847 FYSLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFS 2906
F+ L +LRPS VK++ K +G IV T+K ILAVE+NKVL+PP WN+TF+
Sbjct: 3002 FHHLDNLRPSLTPVKEL----------KEPVGQIVCTDKGILAVEQNKVLIPPTWNKTFA 3051
Query: 2907 WGFDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTK 2966
WG+ D SC LG+Y SDK + +E L+ WG+ LCA+CP+P ++T GTSTVVCVWE+ +K
Sbjct: 3052 WGYADLSCRLGTYESDKAMTVYECLSEWGQILCAICPNPKLVITGGTSTVVCVWEMGTSK 3111
Query: 2967 GRPRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREG 3026
+ + + L+QAL GHT VTC AS+ + ++VSGS+D TCI+WDL+ L+ +T+L HR
Sbjct: 3112 EKAKTVTLKQALLGHTDTVTCATASLAYHIIVSGSRDRTCIIWDLNKLSFLTQLRGHRAP 3171
Query: 3027 ISAITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQI 3086
+SA+ I++++G IVSCAG ++ +W++NG P+ S+ T G I CCC+ E WDT +
Sbjct: 3172 VSALCINELTGDIVSCAGTYIHVWSINGNPIVSVNTFTGRSQQIICCCMSEMNEWDTQNV 3231
Query: 3087 IITGSQDGMVRVWKTEDVKMSVPGRPAGE 3115
I+TG DG+VR W+ E + VP PA E
Sbjct: 3232 IVTGHSDGVVRFWRME--FLQVPETPAPE 3258
Score = 55.5 bits (132), Expect = 8e-07
Identities = 23/56 (41%), Positives = 36/56 (64%)
Query: 3126 GHKWEKNLALSRELDVSIALTGKPSKTSPAVTALAVSRNHTKLLVGDERGRIFCWS 3181
G++WE+ L +L + A K + VTAL +S++H+++LVGD RGR+F WS
Sbjct: 3383 GYRWERQLVFRSKLTMHTAFDRKDNAHPAEVTALGISKDHSRILVGDSRGRVFSWS 3438
>gi|54292123 lysosomal trafficking regulator [Homo sapiens]
Length = 3801
Score = 380 bits (975), Expect = e-104
Identities = 276/922 (29%), Positives = 425/922 (46%), Gaps = 150/922 (16%)
Query: 2245 HVQRRKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRL 2304
H++ ++ A+ W + +QL + +W + + W+LD EGP R R+R++R
Sbjct: 2908 HIRGMYKVDLSASRHWQELIQQLTHDRAVWY--DPIYYPTSWQLDPTEGPNRERRRLQRC 2965
Query: 2305 SPLEALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHES 2364
+++ N + LR+ + D V + L F H S
Sbjct: 2966 -------------------YLTIPN-----KYLLRDRQKSEDVVKPPLSYL-FEDKTHSS 3000
Query: 2365 LHSEDFLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTL 2424
S +++ E + + V + G LL G Y E+
Sbjct: 3001 FSST------------VKDKAASESIRVNRRCISVAPSRETAGELLLGKCGMYFVED--- 3045
Query: 2425 SPTGDVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALE 2484
N SD + + +S +Y +++E+ + + L+D A+E
Sbjct: 3046 --------------NASDTVESSSLQGELEPASFSW---TYEEIKEVHKRWWQLRDNAVE 3088
Query: 2485 IFFHNGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLSLRRYPGSDRIMLQKWQK 2544
IF NG + L F N + + + + +L Y G+ + W
Sbjct: 3089 IFLTNGRTLLLAFDNT----------KVRDDVYHNILTNNLPNLLEY-GNITALTNLWYT 3137
Query: 2545 RDISNFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQT 2604
I+NFEYL +LN AGR+ ND MQYPVFP++LADY SETL+L + I+R+LSKP+ Q
Sbjct: 3138 GQITNFEYLTHLNKHAGRSFNDLMQYPVFPFILADYVSETLDLNDLLIYRNLSKPIAVQY 3197
Query: 2605 KERKLKFIQRFKEVEKT------EGDMTVQC---HYYTHYSSAIIVASYLVRMPPFTQAF 2655
KE++ +++ +K +E+ E D HY +HYS++ V +LVRMPPFT+ F
Sbjct: 3198 KEKEDRYVDTYKYLEEEYRKGAREDDPMPPVQPYHYGSHYSNSGTVLHFLVRMPPFTKMF 3257
Query: 2656 CALQGGSFDVADRMFHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQD 2715
A Q SFD+ DR FHS +TW +S E+M+DV+EL PEFFYLPEFL N G +FG Q+
Sbjct: 3258 LAYQDQSFDIPDRTFHSTNTTWRLSSFESMTDVKELIPEFFYLPEFLVNREGFDFGVRQN 3317
Query: 2716 GTVLGDVQLPPWADGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNI 2775
G + V LPPWA DPR FI +HR+ALESD+VS N+ WIDL+FGYKQ+G A+V A+N+
Sbjct: 3318 GERVNHVNLPPWARNDPRLFILIHRQALESDYVSQNICQWIDLVFGYKQKGKASVQAINV 3377
Query: 2776 FHPYFYGDRMDLSSITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPG----- 2830
FHP Y MD+S++ DP+ + + + +GQ P+QLF H +R A + G
Sbjct: 3378 FHPATYFG-MDVSAVEDPVQRRALETMIKTYGQTPRQLFHMAHVSRPGAKLNIEGELPAA 3436
Query: 2831 ----------------KDVSTP--------------VSLPGHPQPF----------FYSL 2850
K+++ P V P P P F SL
Sbjct: 3437 VGLLVQFAFRETREQVKEITYPSPLSWIKGLKWGEYVGSPSAPVPVVCFSQPHGERFGSL 3496
Query: 2851 QSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWGFD 2910
Q+L + L + S + + + ST+ W+ SWG+
Sbjct: 3497 QALPTRAICGLSRNFCLLMTYSKEQGVRSMNSTDIQ--------------WSAILSWGYA 3542
Query: 2911 DFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGRPR 2970
D L S S+ + ++ + CA P + T V+ + T P
Sbjct: 3543 DNILRLKSKQSEPPVNFIQSSQQYQVTSCAWVPDSCQLFTGSKCGVITAYTNRFTSSTPS 3602
Query: 2971 GLRLRQA--LYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGIS 3028
+ + LYGHT+ +T L +S+L+S S+D TCI+WDL+ L +V L H+ ++
Sbjct: 3603 EIEMETQIHLYGHTEEITSLFVCKPYSILISVSRDGTCIIWDLNRLCYVQSLAGHKSPVT 3662
Query: 3029 AITISDVSGTIVSC-----AGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDT 3083
A++ S+ SG I + G+ L LW VNG + + I P +
Sbjct: 3663 AVSASETSGDIATVCDSAGGGSDLRLWTVNGDLVGHVHC----REIICSVAFSNQPEGVS 3718
Query: 3084 SQIIITGSQDGMVRVWKTEDVK 3105
+I G ++G+VR+W T D+K
Sbjct: 3719 INVIAGGLENGIVRLWSTWDLK 3740
>gi|148233596 LPS-responsive vesicle trafficking, beach and anchor
containing [Homo sapiens]
Length = 2863
Score = 341 bits (875), Expect = 6e-93
Identities = 296/976 (30%), Positives = 437/976 (44%), Gaps = 154/976 (15%)
Query: 2239 ASLYKDHVQRRKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMR 2298
A+ Y+DHV A +I L + G W ++P W LD+ E R R
Sbjct: 1941 AAKYRDHVT--------ATQLIQKIINILTDKHGAWGNSAVSRPLEFWRLDYWEDDLRRR 1992
Query: 2299 KRIKRLSPLEALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFF 2358
+R R +PL H E+ K T E+ LRE DE
Sbjct: 1993 RRFVR-NPL----GSTHPEATLK------TAVEHVCIFKLRENSKATDE--------DIL 2033
Query: 2359 PALHESLHSEDFLELCRERQVILQ---------ELLDKEKVTQKFSLVIVQGHLVSEGVL 2409
+S+ S+ E +++L+ + D E + SL LV+ V+
Sbjct: 2034 AKGKQSIRSQALGNQNSENEILLEGDDDTLSSVDEKDLENLAGPVSLS-TPAQLVAPSVV 2092
Query: 2410 LFGHQHFYICENFTLSPTGDVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHS---YA 2466
+ G TLS T + + DP N D Y+ H +
Sbjct: 2093 VKG----------TLSVTSSEL---YFEVDEEDP---NFKKIDPKILAYTEGLHGKWLFT 2136
Query: 2467 DMRELRQARFLLQDIALEIFFHNGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTL 2526
++R + R+LLQ+ ALEIF N + V +N K ++ P + G TS
Sbjct: 2137 EIRSIFSRRYLLQNTALEIFMAN---RVAVMFNFPDPATVKKVVNYLPRV-GVGTSFGLP 2192
Query: 2527 SLRRYP-GSDRI------MLQKWQKRDISNFEYLMYLNTAAGRTCNDYMQYPVFPWVLAD 2579
RR S R M Q+WQ R+ISNFEYLM+LNT AGR+ ND QYPVFPWV+ +
Sbjct: 2193 QTRRISLASPRQLFKASNMTQRWQHREISNFEYLMFLNTIAGRSYNDLNQYPVFPWVITN 2252
Query: 2580 YTSETLNLANPKIFRDLSKPMGAQTKERKLKFIQRFKEVEKTEGDMTVQCHYYTHYSSAI 2639
Y SE L+L P FRDLSKP+GA +R F +R+ E E D + HY THYS+A
Sbjct: 2253 YESEELDLTLPTNFRDLSKPIGALNPKRAAFFAERY---ESWEDDQVPKFHYGTHYSTAS 2309
Query: 2640 IVASYLVRMPPFTQAFCALQGGSFDVADRMFHSVKSTWESASRENMSDVRELTPEFFYLP 2699
V ++L+R+ PFT F LQGG FD ADR F S+ W ++ R+ SD++EL PEF+YLP
Sbjct: 2310 FVLAWLLRIEPFTTYFLNLQGGKFDHADRTFSSISRAWRNSQRDT-SDIKELIPEFYYLP 2368
Query: 2700 EFLTNCNGVEFGCMQDGTVLGDVQLPPWADGDPRKFISLHRKALESDFVSANLHHWIDLI 2759
E N N G M DGTV+ DV+LPPWA +F+ ++R ALES+FVS LH WIDLI
Sbjct: 2369 EMFVNFNNYNLGVMDDGTVVSDVELPPWAKTS-EEFVHINRLALESEFVSCQLHQWIDLI 2427
Query: 2760 FGYKQQGPAAVDAVNIFHPYFYGDRMDLSSITDPLIKSTILGFVSNFGQVPKQLFTKPHP 2819
FGYKQQGP AV A+N+F+ Y ++L+SITDP+++ + + +FGQ P QL +PHP
Sbjct: 2428 FGYKQQGPEAVRALNVFYYLTYEGAVNLNSITDPVLREAVEAQIRSFGQTPSQLLIEPHP 2487
Query: 2820 ARTAAGKPLP-------GKDVSTPVSLPGHPQPFFYSLQS----LRPSQVTVKDMYLFSL 2868
R +A + P +DV + P + + + P+ +TV LF++
Sbjct: 2488 PRGSAMQVSPLMFTDKAQQDVIMVLKFPSNSPVTHVAANTQPGLATPAVITVTANRLFAV 2547
Query: 2869 GSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWGFDDFSCCLGSYGSDKVLMTF 2928
A V + L VE + PL + G + +
Sbjct: 2548 NKWHNLPAHQGAVQDQPYQLPVE-----IDPL-----------IASNTGMHRRQITDLLD 2591
Query: 2929 ENLAAWGRCLCAVCPSPTTIVTSGTSTVVC-VWELSMTKGRPRGLRLRQALYGHTQAVTC 2987
+++ +C I + +VC W+ S RL Q ++GH VTC
Sbjct: 2592 QSIQVHSQCF--------VITSDNRYILVCGFWDKSFRVYSTDTGRLIQVVFGHWDVVTC 2643
Query: 2988 LAASVTF----SLLVSGSQDCTCILWDLDHLTHVTRLPAHREGISAITISDVSGTIVSCA 3043
LA S ++ ++SGS+D T +LW + C+
Sbjct: 2644 LARSESYIGGNCYILSGSRDATLLLWYWNG---------------------------KCS 2676
Query: 3044 GAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIIITGSQDGMVRVWKTE- 3102
G + + P A +T G + +TC + ++++GSQ+G +
Sbjct: 2677 GIGDNPGSETAAPRAILT---GHDYEVTCAAVCA-----ELGLVLSGSQEGPCLIHSMNG 2728
Query: 3103 DVKMSVPGRPAGEEPPAQPPSPRGH---KWEKNLALSRELDVSIALTGKPSKTSPAVTAL 3159
D+ ++ G +P S GH +E L + ++ + T +T + A+
Sbjct: 2729 DLLRTLEGPENCLKPKLIQASREGHCVIFYENGLFCTFSVNGKLQAT---METDDNIRAI 2785
Query: 3160 AVSRNHTKLLVGDERG 3175
+SR+ LL G +RG
Sbjct: 2786 QLSRDGQYLLTGGDRG 2801
Score = 37.4 bits (85), Expect = 0.24
Identities = 37/143 (25%), Positives = 59/143 (41%), Gaps = 12/143 (8%)
Query: 2975 RQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLD-HLTHVTRLPAHREGISAITIS 3033
R L GH VTC A L++SGSQ+ C++ ++ L P + I S
Sbjct: 2690 RAILTGHDYEVTCAAVCAELGLVLSGSQEGPCLIHSMNGDLLRTLEGPENCLKPKLIQAS 2749
Query: 3034 DVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIIITGSQD 3093
++ ++VNG+ A++ T + I L Q ++TG
Sbjct: 2750 REGHCVIFYENGLFCTFSVNGKLQATMET----DDNIRAIQLSR-----DGQYLLTGGDR 2800
Query: 3094 GMVRVWKTEDVK--MSVPGRPAG 3114
G+V V + D+K + PG AG
Sbjct: 2801 GVVVVRQVSDLKQLFAYPGCDAG 2823
>gi|149944548 neurobeachin-like 2 [Homo sapiens]
Length = 2754
Score = 337 bits (863), Expect = 1e-91
Identities = 276/921 (29%), Positives = 407/921 (44%), Gaps = 134/921 (14%)
Query: 2171 WQHYLASEKKSLASRSNV-----AHHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVS 2225
W+H++ + + S+ + +H W+ M RQ + + +
Sbjct: 1710 WRHFIDKQVQPTMSQFEMDTYAKSHDLMSGFWNACYDMLMSSGQRRQWERAQSRRAFQEL 1769
Query: 2226 CIENYRRRGQELYASLYKDHVQRRKCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSP 2285
+E +RR + L Y ++++ + A W + QL G W+ + P
Sbjct: 1770 VLEPAQRRAR-LEGLRYTAVLKQQATQHSMALLHWGALWRQLASPCGAWALRDT--PIPR 1826
Query: 2286 WELDWREGPARMRKRIKRLSPLEALSSGRHKESQDKNDHISQTNAENQDELTLREAEGEP 2345
W+L E +RMR ++ + H E+ D++ + +E +L A +
Sbjct: 1827 WKLSSAETYSRMRLKLVPNHHFDP-----HLEASALRDNLGEVPLTPTEEASLPLAVTKE 1881
Query: 2346 DEVGVDCTQLTFFPALHESLHSEDFLELCRERQVI-LQELLDKEKVTQKFSLVIVQGHLV 2404
+V L + L ++ EL + L E +K ++ + LV V V
Sbjct: 1882 AKVSTPPELLQ-----EDQLGEDELAELETPMEAAELDEQREKLVLSAECQLVTVVA--V 1934
Query: 2405 SEGVLLFGHQHFYICENFTL---SPTGDVYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQ 2461
G+L Q+ Y + T + G Y R L
Sbjct: 1935 VPGLLEVTTQNVYFYDGSTERVETEEGIGYDFRRPL------------------------ 1970
Query: 2462 CHSYADMRELRQARFLLQDIALEIFFHNGYSKFLVF------------------------ 2497
A +RE+ RF L+ ALE+FF + + FL F
Sbjct: 1971 ----AQLREVHLRRFNLRRSALELFFIDQANYFLNFPCKVGTTPVSSPSQTPRPQPGPIP 2026
Query: 2498 -YNNDRSKAFKSFCSFQPSLKGKATSEDTLSLRRYPGSDRIMLQKWQKRDISNFEYLMYL 2556
+ R++ + +P +G +S + R G + QKW +R+ISNFEYLM L
Sbjct: 2027 PHTQVRNQVYSWLLRLRPPSQGYLSSRSPQEMLRASG----LTQKWVQREISNFEYLMQL 2082
Query: 2557 NTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERKLKFIQRFK 2616
NT AGRT ND QYPVFPWVL DY S TL+L+NP +FRDLSKP+G + ++++
Sbjct: 2083 NTIAGRTYNDLSQYPVFPWVLQDYVSPTLDLSNPAVFRDLSKPIGVVNPKHAQLVREKYE 2142
Query: 2617 EVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADRMFHSVKST 2676
E G + + HY THYS+A V YL+R+ PFT LQ G FD +DR FHSV +
Sbjct: 2143 SFEDPAGTID-KFHYGTHYSNAAGVMHYLIRVEPFTSLHVQLQSGRFDCSDRQFHSVAAA 2201
Query: 2677 WESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQ-DGTVLGDVQLPPWADGDPRKF 2735
W+ A E+ +DV+EL PEFFY P+FL N NG + GC+Q +GDV LPPWA P F
Sbjct: 2202 WQ-ARLESPADVKELIPEFFYFPDFLENQNGFDLGCLQLTNEKVGDVVLPPWASS-PEDF 2259
Query: 2736 ISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLSSITDPLI 2795
I HR+ALES++VSA+LH WIDLIFGYKQ+GPAA +A+N+F+ Y +DL +TD
Sbjct: 2260 IQQHRQALESEYVSAHLHEWIDLIFGYKQRGPAAEEALNVFYYCTYEGAVDLDHVTDERE 2319
Query: 2796 KSTILGFVSNFGQVPKQLFTKPHPARTAAGKP---LPGKDVSTP---------------- 2836
+ + G +SNFGQ P QL +PHP R +A + L D ++P
Sbjct: 2320 RKALEGIISNFGQTPCQLLKEPHPTRLSAEEAAHRLARLDTNSPSIFQHLDELKAFFAEV 2379
Query: 2837 --------VSLPGHPQPFFYSLQSLRPSQVTVKDMYLFSLGSESP--KGAIGHIVSTEKT 2886
++L H QP + Q VTV L S P + + ++
Sbjct: 2380 VSDGVPLVLALVPHRQPHSFITQGSPDLLVTVSASGLLGTHSWLPYDRNISNYFSFSKDP 2439
Query: 2887 ILAVERNKVLLPPLW-----------------NRTFSWGFDDFSCCLGSYGSDKVLMTFE 2929
+ + + LL W FS G D S + + K+L
Sbjct: 2440 TMGSHKTQRLLSGPWVPGSGVSGQALAVAPDGKLLFSGGHWDGSLRVTALPRGKLLSQLS 2499
Query: 2930 NLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGRPRGLRLR--QALYGHTQAVTC 2987
CL A+ +++ T VW L G GL + Q LYGH AV+C
Sbjct: 2500 CHLDVVTCL-ALDTCGIYLISGSRDTTCMVWRLLHQGGLSVGLAPKPVQVLYGHGAAVSC 2558
Query: 2988 LAASVTFSLLVSGSQDCTCIL 3008
+A S + VSGS+D T I+
Sbjct: 2559 VAISTELDMAVSGSEDGTVII 2579
>gi|224451124 neurobeachin-like 1 isoform 3 [Homo sapiens]
Length = 2694
Score = 325 bits (833), Expect = 4e-88
Identities = 280/982 (28%), Positives = 444/982 (45%), Gaps = 129/982 (13%)
Query: 2190 HHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQRR 2249
H + W + M M R + E K + +E + R+ ++ Y + +++
Sbjct: 1706 HENMALYWKDCYEALMVNMHKRDREGGESKLKFQELFVEPFNRKARQENLR-YNNMLKQL 1764
Query: 2250 KCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLEA 2309
+ W IQ L E G W++ ++ W+L E +RMR ++ +
Sbjct: 1765 SSQQLATLRRWKAIQLYLTCERGPWAKRKQNP--IHWKLANVENYSRMRLKL-----VPN 1817
Query: 2310 LSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSED 2369
+ H+E+ D++ +++ + L E + + S ED
Sbjct: 1818 YNFKTHEEASALRDNLGIQHSQPSSDTLLLEVVKQ----------------VKVSDMVED 1861
Query: 2370 FLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTGD 2429
L+L E + +KE+ QK LV+++ CE T+ D
Sbjct: 1862 KLDLPEEDITARVNVDEKEEQDQKEKLVLMED-----------------CELITII---D 1901
Query: 2430 VYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFHN 2489
V R ++ F K+ HS +RE+ R+ L+ ALEIF +
Sbjct: 1902 VIPGRLEITTQHIYFYDGSIEKEDGVGFDFKWPHS--QIREIHLRRYNLRRSALEIFHVD 1959
Query: 2490 GYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLSLRRYPGSDRIMLQKWQKRDISN 2549
+ FL F R+K + S S S L + G + QKW R+ISN
Sbjct: 1960 QSNYFLNFKKEVRNKIYSRLLSLH-SPNSYYGSRSPQELFKASG----LTQKWVNREISN 2014
Query: 2550 FEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERKL 2609
F+YL+ +NT AGRT ND QYPVFPW+L DYTSE L+L NP +FRDLSKP+G ++
Sbjct: 2015 FDYLIQINTMAGRTYNDLAQYPVFPWILQDYTSEELDLNNPAVFRDLSKPIGVVNEKNAK 2074
Query: 2610 KFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADRM 2669
++++ E G + + HY THYS++ V YL+R+ PFT LQ G FD ADR
Sbjct: 2075 AMREKYENFEDPMGTID-KFHYGTHYSNSAGVMHYLIRVEPFTTLHIQLQSGRFDCADRQ 2133
Query: 2670 FHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQ-DGTVLGDVQLPPWA 2728
FHS+ +TW+ A +N DV+EL PEFFY PEFL N N G +Q ++ DV LP WA
Sbjct: 2134 FHSIPATWQ-ALMDNPYDVKELIPEFFYFPEFLENQNQFNLGRLQISKELVNDVILPKWA 2192
Query: 2729 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS 2788
FI HRKALES++VSA+LH WIDLIFGYKQ+GPAAV+A+N+F+ Y +DL
Sbjct: 2193 KS-AEDFIYKHRKALESEYVSAHLHEWIDLIFGYKQRGPAAVEALNVFYYCSYEGAVDLD 2251
Query: 2789 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPL--PGKDVSTPVSLPGH-PQP 2845
++TD + + G ++NFGQ P QL +PHP R +A + + P K ++ ++L H P+
Sbjct: 2252 ALTDEKERKALEGMINNFGQTPCQLLKEPHPPRLSAEEAVQKPTKIDTSTLNLFQHLPEL 2311
Query: 2846 FFYSLQSLRPS----QVTV-KDMYLFSLGSESPKGAI----GHIVSTE---------KTI 2887
+ ++ + + T+ K+ Y + SP+ I +++ T
Sbjct: 2312 KSFFIEGISDGIPLLKATIPKNQYRSFMSQGSPELLITISMNYVIGTHGWLPYDRNISNY 2371
Query: 2888 LAVERNKVLLPPLWNRT-------------------------FSWGFDDFSCCLGSYGSD 2922
+++ + P R+ FS G+ D S + S
Sbjct: 2372 FTFIKDQTVTNPKTQRSINGSFAPGLEITSKLFVVSHDAKLLFSAGYWDNSIQVMSLTKG 2431
Query: 2923 KVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGRPRGLRLR--QALYG 2980
K++ CL A +++ T +W+++ G P GL + Q LYG
Sbjct: 2432 KIISHIIRHMDIVTCL-ATDYCGIHLISGSRDTTCMIWQITQQGGVPVGLASKPFQILYG 2490
Query: 2981 HTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGISAITISDVS---- 3036
HT V + S + VSGS+D T I+ + ++ L E +TI +++
Sbjct: 2491 HTNEVLSVGISTELDMAVSGSRDGTVIIHTIQKGQYMRTLRPPCESSLFLTIPNLAISWE 2550
Query: 3037 GTIVSCAGAH----------LSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQI 3086
G IV + L L+++NG+ L S + ++ C++ +
Sbjct: 2551 GHIVVYSSTEEKTTLKDKNALHLFSINGKYLGSQIL----KEQVSDICII-------GEH 2599
Query: 3087 IITGSQDGMVRVWKTEDVKMSV 3108
I+TGS G + + + +S+
Sbjct: 2600 IVTGSIQGFLSIRDLHSLNLSI 2621
>gi|149944613 neurobeachin-like 1 isoform 1 [Homo sapiens]
Length = 1404
Score = 325 bits (833), Expect = 4e-88
Identities = 280/982 (28%), Positives = 444/982 (45%), Gaps = 129/982 (13%)
Query: 2190 HHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQRR 2249
H + W + M M R + E K + +E + R+ ++ Y + +++
Sbjct: 416 HENMALYWKDCYEALMVNMHKRDREGGESKLKFQELFVEPFNRKARQENLR-YNNMLKQL 474
Query: 2250 KCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLEA 2309
+ W IQ L E G W++ ++ W+L E +RMR ++ +
Sbjct: 475 SSQQLATLRRWKAIQLYLTCERGPWAKRKQNP--IHWKLANVENYSRMRLKL-----VPN 527
Query: 2310 LSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSED 2369
+ H+E+ D++ +++ + L E + + S ED
Sbjct: 528 YNFKTHEEASALRDNLGIQHSQPSSDTLLLEVVKQ----------------VKVSDMVED 571
Query: 2370 FLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTGD 2429
L+L E + +KE+ QK LV+++ CE T+ D
Sbjct: 572 KLDLPEEDITARVNVDEKEEQDQKEKLVLMED-----------------CELITII---D 611
Query: 2430 VYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFHN 2489
V R ++ F K+ HS +RE+ R+ L+ ALEIF +
Sbjct: 612 VIPGRLEITTQHIYFYDGSIEKEDGVGFDFKWPHS--QIREIHLRRYNLRRSALEIFHVD 669
Query: 2490 GYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLSLRRYPGSDRIMLQKWQKRDISN 2549
+ FL F R+K + S S S L + G + QKW R+ISN
Sbjct: 670 QSNYFLNFKKEVRNKIYSRLLSLH-SPNSYYGSRSPQELFKASG----LTQKWVNREISN 724
Query: 2550 FEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERKL 2609
F+YL+ +NT AGRT ND QYPVFPW+L DYTSE L+L NP +FRDLSKP+G ++
Sbjct: 725 FDYLIQINTMAGRTYNDLAQYPVFPWILQDYTSEELDLNNPAVFRDLSKPIGVVNEKNAK 784
Query: 2610 KFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADRM 2669
++++ E G + + HY THYS++ V YL+R+ PFT LQ G FD ADR
Sbjct: 785 AMREKYENFEDPMGTID-KFHYGTHYSNSAGVMHYLIRVEPFTTLHIQLQSGRFDCADRQ 843
Query: 2670 FHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQ-DGTVLGDVQLPPWA 2728
FHS+ +TW+ A +N DV+EL PEFFY PEFL N N G +Q ++ DV LP WA
Sbjct: 844 FHSIPATWQ-ALMDNPYDVKELIPEFFYFPEFLENQNQFNLGRLQISKELVNDVILPKWA 902
Query: 2729 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS 2788
FI HRKALES++VSA+LH WIDLIFGYKQ+GPAAV+A+N+F+ Y +DL
Sbjct: 903 KS-AEDFIYKHRKALESEYVSAHLHEWIDLIFGYKQRGPAAVEALNVFYYCSYEGAVDLD 961
Query: 2789 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPL--PGKDVSTPVSLPGH-PQP 2845
++TD + + G ++NFGQ P QL +PHP R +A + + P K ++ ++L H P+
Sbjct: 962 ALTDEKERKALEGMINNFGQTPCQLLKEPHPPRLSAEEAVQKPTKIDTSTLNLFQHLPEL 1021
Query: 2846 FFYSLQSLRPS----QVTV-KDMYLFSLGSESPKGAI----GHIVSTE---------KTI 2887
+ ++ + + T+ K+ Y + SP+ I +++ T
Sbjct: 1022 KSFFIEGISDGIPLLKATIPKNQYRSFMSQGSPELLITISMNYVIGTHGWLPYDRNISNY 1081
Query: 2888 LAVERNKVLLPPLWNRT-------------------------FSWGFDDFSCCLGSYGSD 2922
+++ + P R+ FS G+ D S + S
Sbjct: 1082 FTFIKDQTVTNPKTQRSINGSFAPGLEITSKLFVVSHDAKLLFSAGYWDNSIQVMSLTKG 1141
Query: 2923 KVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGRPRGLRLR--QALYG 2980
K++ CL A +++ T +W+++ G P GL + Q LYG
Sbjct: 1142 KIISHIIRHMDIVTCL-ATDYCGIHLISGSRDTTCMIWQITQQGGVPVGLASKPFQILYG 1200
Query: 2981 HTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGISAITISDVS---- 3036
HT V + S + VSGS+D T I+ + ++ L E +TI +++
Sbjct: 1201 HTNEVLSVGISTELDMAVSGSRDGTVIIHTIQKGQYMRTLRPPCESSLFLTIPNLAISWE 1260
Query: 3037 GTIVSCAGAH----------LSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQI 3086
G IV + L L+++NG+ L S + ++ C++ +
Sbjct: 1261 GHIVVYSSTEEKTTLKDKNALHLFSINGKYLGSQIL----KEQVSDICII-------GEH 1309
Query: 3087 IITGSQDGMVRVWKTEDVKMSV 3108
I+TGS G + + + +S+
Sbjct: 1310 IVTGSIQGFLSIRDLHSLNLSI 1331
>gi|62422577 neurobeachin [Homo sapiens]
Length = 2946
Score = 324 bits (831), Expect = 7e-88
Identities = 217/579 (37%), Positives = 302/579 (52%), Gaps = 70/579 (12%)
Query: 2465 YADMRELRQARFLLQDIALEIFFHNGYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSED 2524
++++R + R+LLQ+ ALE+F N S V +N K P + G TS
Sbjct: 2209 FSEIRAVFSRRYLLQNTALEVFMANRTS---VMFNFPDQATVKKVVYSLPRV-GVGTSYG 2264
Query: 2525 TLSLRR---------YPGSDRIMLQKWQKRDISNFEYLMYLNTAAGRTCNDYMQYPVFPW 2575
RR Y S+ M Q+WQ+R+ISNFEYLM+LNT AGRT ND QYPVFPW
Sbjct: 2265 LPQARRISLATPRQLYKSSN--MTQRWQRREISNFEYLMFLNTIAGRTYNDLNQYPVFPW 2322
Query: 2576 VLADYTSETLNLANPKIFRDLSKPMGAQTKERKLKFIQRFKEVEKTEGDMTVQCHYYTHY 2635
VL +Y SE L+L P FRDLSKP+GA +R + + +R+ E E D + HY THY
Sbjct: 2323 VLTNYESEELDLTLPGNFRDLSKPIGALNPKRAVFYAERY---ETWEDDQSPPYHYNTHY 2379
Query: 2636 SSAIIVASYLVRMPPFTQAFCALQGGSFDVADRMFHSVKSTWESASRENMSDVRELTPEF 2695
S+A S+LVR+ PFT F G FD DR F SV +W ++ R+ SDV+EL PEF
Sbjct: 2380 STATSTLSWLVRIEPFTTFFLNANDGKFDHPDRTFSSVARSWRTSQRDT-SDVKELIPEF 2438
Query: 2696 FYLPEFLTNCNGVEFGCMQDGTVLGDVQLPPWADGDPRKFISLHRKALESDFVSANLHHW 2755
+YLPE N NG G +D V+ DV LPPWA P F+ ++R ALES+FVS LH W
Sbjct: 2439 YYLPEMFVNSNGYNLGVREDEVVVNDVDLPPWAK-KPEDFVRINRMALESEFVSCQLHQW 2497
Query: 2756 IDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLSSITDPLIKSTILGFVSNFGQVPKQLFT 2815
IDLIFGYKQ+GP AV A+N+FH Y ++L SITDP+++ + + NFGQ P QL
Sbjct: 2498 IDLIFGYKQRGPEAVRALNVFHYLTYEGSVNLDSITDPVLREAMEAQIQNFGQTPSQLLI 2557
Query: 2816 KPHPARTAA-------GKPLPGK-----DVSTPVSLPGHPQPFFYSLQSLR----PSQVT 2859
+PHP R++A PL K DV + P + + +L P+ VT
Sbjct: 2558 EPHPPRSSAMHLCFLPQSPLMFKDQMQQDVIMVLKFPSNSPVTHVAANTLPHLTIPAVVT 2617
Query: 2860 VKDMYLFSL----GSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWGFDDFSCC 2915
V LF++ + +GA G+ + + L +E + ++
Sbjct: 2618 VTCSRLFAVNRWHNTVGLRGAPGYSLD-QAHHLPIEMDPLI------------------- 2657
Query: 2916 LGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVC-VWELSMTKGRPRGLRL 2974
+ G +K +T +L + A C + ++C W+ S +L
Sbjct: 2658 ANNSGVNKRQIT--DLVDQSIQINAHC---FVVTADNRYILICGFWDKSFRVYSTETGKL 2712
Query: 2975 RQALYGHTQAVTCLAASVTF----SLLVSGSQDCTCILW 3009
Q ++GH VTCLA S ++ +VSGS+D T +LW
Sbjct: 2713 TQIVFGHWDVVTCLARSESYIGGDCYIVSGSRDATLLLW 2751
Score = 40.8 bits (94), Expect = 0.022
Identities = 65/267 (24%), Positives = 118/267 (44%), Gaps = 44/267 (16%)
Query: 1233 RLGPTYLFEEAISMETLEVINKLGPRYCGNFQAVHVQGEDLDSEATPFVAE--ERVSFGL 1290
+LG Y+F EA++ + I++LGP Y F+ SE+ +AE ++V +
Sbjct: 386 QLGAVYVFSEALNPAQIFAIHQLGPGYKSTFK--------FKSESDIHLAEHHKQVLYDG 437
Query: 1291 HIASSSITSVADIRNAYNEVDSRLIAKEMNISSRDNAMPVFLLRNCAGHLSGSLRTIGAV 1350
+ASS +A NA D++L + S ++NA +F+ H +L
Sbjct: 438 KLASS----IAFTYNA-KATDAQLCLES---SPKENAS-IFV------HSPHALMLQDVK 482
Query: 1351 AVGQLGVRVFHSSPAASSLDFIGGPAILLGLISLATDDHTMYAAVKV---------LHSV 1401
A+ V HS S++ IGG +L L + + + V+ L +
Sbjct: 483 AI------VTHS--IHSAIHSIGGIQVLFPLFAQLDNRQLNDSQVETTVCATLLAFLVEL 534
Query: 1402 LTSNAMCDFLMQHICGYQIMAFLLRKKASL-LNHRIFQLILSVAGTVELGFRSSAITNTG 1460
L S+ M G+ ++ +LL K + + + + + LS A ++ G A
Sbjct: 535 LKSSVAMQEQMLGGKGFLVIGYLLEKSSRVHITRAVLEQFLSFAKYLD-GLSHGAPLLKQ 593
Query: 1461 VFQHILCNFELWMNTADNLELSLFSHL 1487
+ HIL N +W++T ++LSL+++L
Sbjct: 594 LCDHILFNPAIWIHTPAKVQLSLYTYL 620
Score = 40.4 bits (93), Expect = 0.028
Identities = 33/143 (23%), Positives = 58/143 (40%), Gaps = 12/143 (8%)
Query: 2975 RQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDL-DHLTHVTRLPAHREGISAITIS 3033
R L GH V C++ L++SG+++ C++ + L P + I++S
Sbjct: 2773 RAVLTGHDHEVVCVSVCAELGLVISGAKEGPCLVHTITGDLLRALEGPENCLFPRLISVS 2832
Query: 3034 DVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIIITGSQD 3093
I+ S +++NG+ LA + + Q ++TG +
Sbjct: 2833 SEGHCIIYYERGRFSNFSINGKLLAQMEINDSTRAILLS---------SDGQNLVTGGDN 2883
Query: 3094 GMVRVWKTEDVKM--SVPGRPAG 3114
G+V VW+ D K PG AG
Sbjct: 2884 GVVEVWQACDFKQLYIYPGCDAG 2906
>gi|154240744 neurobeachin-like 1 isoform 2 [Homo sapiens]
Length = 1335
Score = 315 bits (808), Expect = 3e-85
Identities = 275/936 (29%), Positives = 420/936 (44%), Gaps = 106/936 (11%)
Query: 2190 HHSKVTLWSGSLSSAMKLMPGRQAKDPECKTEDFVSCIENYRRRGQELYASLYKDHVQRR 2249
H + W + M M R + E K + +E + R+ ++ Y + +++
Sbjct: 416 HENMALYWKDCYEALMVNMHKRDREGGESKLKFQELFVEPFNRKARQENLR-YNNMLKQL 474
Query: 2250 KCGNIKAANAWARIQEQLFGELGLWSQGEETKPCSPWELDWREGPARMRKRIKRLSPLEA 2309
+ W IQ L E G W++ ++ W+L E +RMR ++ +
Sbjct: 475 SSQQLATLRRWKAIQLYLTCERGPWAKRKQNP--IHWKLANVENYSRMRLKL-----VPN 527
Query: 2310 LSSGRHKESQDKNDHISQTNAENQDELTLREAEGEPDEVGVDCTQLTFFPALHESLHSED 2369
+ H+E+ D++ +++ + L E + + S ED
Sbjct: 528 YNFKTHEEASALRDNLGIQHSQPSSDTLLLEVVKQ----------------VKVSDMVED 571
Query: 2370 FLELCRERQVILQELLDKEKVTQKFSLVIVQGHLVSEGVLLFGHQHFYICENFTLSPTGD 2429
L+L E + +KE+ QK LV+++ CE T+ D
Sbjct: 572 KLDLPEEDITARVNVDEKEEQDQKEKLVLMED-----------------CELITII---D 611
Query: 2430 VYCTRHCLSNISDPFIFNLCSKDRSTDHYSCQCHSYADMRELRQARFLLQDIALEIFFHN 2489
V R ++ F K+ HS +RE+ R+ L+ ALEIF +
Sbjct: 612 VIPGRLEITTQHIYFYDGSIEKEDGVGFDFKWPHS--QIREIHLRRYNLRRSALEIFHVD 669
Query: 2490 GYSKFLVFYNNDRSKAFKSFCSFQPSLKGKATSEDTLSLRRYPGSDRIMLQKWQKRDISN 2549
+ FL F R+K + S S S L + G + QKW R+ISN
Sbjct: 670 QSNYFLNFKKEVRNKIYSRLLSLH-SPNSYYGSRSPQELFKASG----LTQKWVNREISN 724
Query: 2550 FEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRDLSKPMGAQTKERKL 2609
F+YL+ +NT AGRT ND QYPVFPW+L DYTSE L+L NP +FRDLSKP+G ++
Sbjct: 725 FDYLIQINTMAGRTYNDLAQYPVFPWILQDYTSEELDLNNPAVFRDLSKPIGVVNEKNAK 784
Query: 2610 KFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMPPFTQAFCALQGGSFDVADRM 2669
++++ E G + + HY THYS++ V YL+R+ PFT LQ G FD ADR
Sbjct: 785 AMREKYENFEDPMGTID-KFHYGTHYSNSAGVMHYLIRVEPFTTLHIQLQSGRFDCADRQ 843
Query: 2670 FHSVKSTWESASRENMSDVRELTPEFFYLPEFLTNCNGVEFGCMQ-DGTVLGDVQLPPWA 2728
FHS+ +TW+ A +N DV+EL PEFFY PEFL N N G +Q ++ DV LP WA
Sbjct: 844 FHSIPATWQ-ALMDNPYDVKELIPEFFYFPEFLENQNQFNLGRLQISKELVNDVILPKWA 902
Query: 2729 DGDPRKFISLHRKALESDFVSANLHHWIDLIFGYKQQGPAAVDAVNIFHPYFYGDRMDLS 2788
FI HRKALES++VSA+LH WIDLIFGYKQ+GPAAV+A+N+F+ Y +DL
Sbjct: 903 KS-AEDFIYKHRKALESEYVSAHLHEWIDLIFGYKQRGPAAVEALNVFYYCSYEGAVDLD 961
Query: 2789 SITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTAAGKPLPGKDVSTPVSLPGHPQPFFY 2848
++TD + + G ++NFGQ P QL G T LP + +
Sbjct: 962 ALTDEKERKALEGMINNFGQTPCQLLKITISMNYVIG---------THGWLP-YDRNISN 1011
Query: 2849 SLQSLRPSQVTVKDMYLFSLGSESPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWG 2908
++ VT GS +P I T K + K+L FS G
Sbjct: 1012 YFTFIKDQTVTNPKTQRSINGSFAPGLEI-----TSKLFVVSHDAKLL--------FSAG 1058
Query: 2909 FDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGR 2968
+ D S + S K++ CL A +++ T +W+++ G
Sbjct: 1059 YWDNSIQVMSLTKGKIISHIIRHMDIVTCL-ATDYCGIHLISGSRDTTCMIWQITQQGGV 1117
Query: 2969 PRGLRLR--QALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREG 3026
P GL + Q LYGHT V + S + VSGS+D T I+ + ++ L E
Sbjct: 1118 PVGLASKPFQILYGHTNEVLSVGISTELDMAVSGSRDGTVIIHTIQKGQYMRTLRPPCES 1177
Query: 3027 ISAITISDVS----GTIVSCAGAH----------LSLWNVNGQPLASITTAWGPEGAITC 3072
+TI +++ G IV + L L+++NG+ L S + ++
Sbjct: 1178 SLFLTIPNLAISWEGHIVVYSSTEEKTTLKDKNALHLFSINGKYLGSQIL----KEQVSD 1233
Query: 3073 CCLMEGPAWDTSQIIITGSQDGMVRVWKTEDVKMSV 3108
C++ + I+TGS G + + + +S+
Sbjct: 1234 ICII-------GEHIVTGSIQGFLSIRDLHSLNLSI 1262
>gi|31317268 WD repeat and FYVE domain containing 3 isoform 2 [Homo
sapiens]
Length = 795
Score = 298 bits (763), Expect = 6e-80
Identities = 222/759 (29%), Positives = 388/759 (51%), Gaps = 40/759 (5%)
Query: 59 HKSPIERQKSLLSLLPLFLKAWEHSVGIIC---FPSLQRLAEDVSDQLAQQLQKALVGKP 115
H + E+++ L +LP+F + + ++ F L + VS + ++++ K
Sbjct: 41 HMTQKEQEEKLYMMLPVFNRVFGNAPPNTMTEKFSDLLQFTTQVSRLMVTEIRRRASNKS 100
Query: 116 AEQARLAAGQLLWWKGDVDQD-----GYLLLKSVYVLTGTDSETLGRVAESGLPALLLQC 170
E A A Q L +++Q G++LL ++ +L + +T+ + +P+ L++C
Sbjct: 101 TEAASRAIVQFL----EINQSEEASRGWMLLTTINLLASSGQKTVDCMTTMSVPSTLVKC 156
Query: 171 LYLFFVFP---------LDKDELLESDLQVQKMFVQMLLNICSDSQGLEGLLSGSELQSL 221
LYLFF P ++ L E +QK+FVQ+L+ +CS E L +LQ L
Sbjct: 157 LYLFFDLPHVPEAVGGAQNELPLAERRGLLQKVFVQILVKLCSFVSPAEELAQKDDLQLL 216
Query: 222 LIATTCLREHSCCFWKEPTFCVLRAISK-AQNLSIIQYLQATDCVRLSLQNLSRLTDTLP 280
A T W++ VL IS+ ++++++Y+ +C+ +QN+ + D P
Sbjct: 217 FSAITSWCPPYNLPWRKSAGEVLMTISRHGLSVNVVKYIHEKECLSTCVQNMQQSDDLSP 276
Query: 281 APEVSEAVSLILGFVKDSYPVSSALFLEFENSEGYPLLLKVLLRYDGLTQSEVDPHLEEL 340
E+ E + + F+KDS VS L +F +GY L +LLR + ++E L++L
Sbjct: 277 L-EIVEMFAGLSCFLKDSSDVSQTLLDDFRIWQGYNFLCDLLLRLEQAKEAESKDALKDL 335
Query: 341 LGLVVWLTTCGRSELKVFDSITYPQ--LEGFKFHHEAS-GVTVKNLQAFQVLQNVFHKAS 397
+ L+ LTT G SELK T L GF A G +V+N+QAF VLQN F KA
Sbjct: 336 VNLITSLTTYGVSELKPAGITTGAPFLLPGFAVPQPAGKGHSVRNVQAFAVLQNAFLKAK 395
Query: 398 DSVLCIQVLSVIRTMWAWNARNFFLLEWTLQPISQFVEIMPLKPAPVQEHFFQLLEALVF 457
S L +L I ++ + N+F+LE + +SQF E + P VQ +F++LE +VF
Sbjct: 396 TSFLAQIILDAITNIYMADNANYFILE-SQHTLSQFAEKISKLPE-VQNKYFEMLEFVVF 453
Query: 458 ELHYVPHEILRKVQHLIKESPGPSCTLMALQSILSIAGGDPLFTDIFRDSGLLGLLLAQL 517
L+Y+P + L V L+K S C+++A++++L D +F D+FR+ GLL +++ L
Sbjct: 454 SLNYIPCKELISVSILLKSSSSYHCSIIAMKTLLKFTRHDYIFKDVFREVGLLEVMVNLL 513
Query: 518 RKQAKIMR-------KSGNKVSTPGVQDPERELTCVMLRIVVTLLKGSVRNAVVLKDHGM 570
K A +++ + G+ + V+D ++ L +++ + LL+GS NA + ++ G
Sbjct: 514 HKYAALLKDPTQALNEQGDSRNNSSVED-QKHLALLVMETLTVLLQGSNTNAGIFREFGG 572
Query: 571 VPFI-KIFLDDECYREASLSILEQLSAINAEEYMSIIVGALCSSTQGELQLKLDLLKSLL 629
I +C + A ++I + + + N ++ M ++G + S+ ELQLK D+L++LL
Sbjct: 573 ARCAHNIVKYPQCRQHALMTIQQLVLSPNGDDDMGTLLGLMHSAPPTELQLKTDILRALL 632
Query: 630 RIL-VTPKGRAAFRVSSGFNGLLSLLSDLEGSLQEPPLQAWGAVSPRQTLELVLYTLCAV 688
+L + + R FR GF + SLL +E SL PP W V+ Q EL+ C +
Sbjct: 633 SVLRESHRSRTVFRKVGGFVYITSLLVAMERSLSCPPKNGWEKVNQNQVFELLHTVFCTL 692
Query: 689 SAALHWDPVNGYFFRRNGLFEKLAEDLCLLGCFGALEEEGNLLRSWVDTKARPFADLLGT 748
+AA+ ++P N +FF+ +EKLA+ + LGCF L + + + + +PF LL
Sbjct: 693 TAAMRYEPANSHFFKTEIQYEKLADAVRFLGCFSDLRKISAM--NVFPSNTQPFQRLLEE 750
Query: 749 AFSSSGSLPPRIQSCLQILGFLDSMASGTLHLRGDLKES 787
S S+ P ++ C ++ +L +A+ + G S
Sbjct: 751 DVISIESVSPTLRHCSKLFIYLYKVATDSFDRYGSALSS 789
>gi|31543297 neutral sphingomyelinase (N-SMase) activation associated
factor isoform 1 [Homo sapiens]
Length = 917
Score = 273 bits (698), Expect = 2e-72
Identities = 215/681 (31%), Positives = 328/681 (48%), Gaps = 80/681 (11%)
Query: 2467 DMRELRQARFLLQDIALEIFFHNG---YSKFLVFYN-NDRSKAFKSFCSFQPSLKGKATS 2522
D+R + + R L + LE+F +L FY DR + ++ + T+
Sbjct: 239 DVRRIYKRRHGLMPLGLEVFCTEDDLCSDIYLKFYEPQDRDDLYFYIATYLEHHVAEHTA 298
Query: 2523 EDTLSLRRYPGSDRIMLQKWQKRDISNFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTS 2582
E MLQ WQ+ +SN++YL++LN A R+CND QYPVFPW++ DY+S
Sbjct: 299 ES------------YMLQ-WQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWIIHDYSS 345
Query: 2583 ETLNLANPKIFRDLSKPMGAQTKERKLKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVA 2642
L+L+NP FRDLSKP+GA KER + + R++E+ + + Y +HYSS V
Sbjct: 346 SELDLSNPGTFRDLSKPVGALNKERLERLLTRYQEMPEPK------FMYGSHYSSPGYVL 399
Query: 2643 SYLVRMPPFTQAFCALQGGSFDVADRMFHSVKSTWESASRENMSDVRELTPEFFYLP-EF 2701
YLVR+ P + LQ G FD ADRMF+S+ TW++ + +D +EL PEF+ F
Sbjct: 400 FYLVRIAP--EYMLCLQNGRFDNADRMFNSIAETWKNCL-DGATDFKELIPEFYGDDVSF 456
Query: 2702 LTNCNGVEFGCMQDGTVLGDVQLPPWADGDPRKFISLHRKALESDFVSANLHHWIDLIFG 2761
L N ++ G Q G ++ DV+LPPWA P F+ + ALES++VS +LH WIDLIFG
Sbjct: 457 LVNSLKLDLGKRQGGQMVDDVELPPWASS-PEDFLQKSKDALESNYVSEHLHEWIDLIFG 515
Query: 2762 YKQQGPAAVDAVNIFHPYFYGDRMDLSSITDPLIKSTILGFVSNFGQVPKQLFTKPHPAR 2821
YKQ+G AV A N+FHP Y +DL+SI DP K +L + FGQ PKQLF PHP R
Sbjct: 516 YKQKGSDAVGAHNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFVTPHPRR 575
Query: 2822 TAAGKPLPGKDVSTPVSLPGHP-QPFFYSL----QSLRPSQVTVKDMY-LFSLGSE---- 2871
+ S S+ P + F L ++L + +T ++ + + E
Sbjct: 576 ITPKFKSLSQTSSYNASMADSPGEESFEDLTEESKTLAWNNITKLQLHEHYKIHKEAVTG 635
Query: 2872 ---SPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWGFDDFSCCLGSYGSDKVLMT- 2927
S G+ S + T+ + +L R+ S+ S CL G V+ +
Sbjct: 636 ITVSRNGSSVFTTSQDSTLKMFSKESKML----QRSISFSNMALSSCLLLPGDATVITSS 691
Query: 2928 -----FENLAAWGR----------CLCAVCPSPTTIVTSGTSTVVCVW-----ELSMTKG 2967
+ A+GR + +C + ++ + V VW E+ TK
Sbjct: 692 WDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLYSASWDSTVKVWSGVPAEMPGTKR 751
Query: 2968 RPRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGI 3027
L A H +V ++ + +LLVSG+++ T +WDL T + ++P H +
Sbjct: 752 HHFDL---LAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIV 808
Query: 3028 SAITISDVSGTIVSC-AGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQI 3086
S S ++S L++ +V L S T+ P+ WD +
Sbjct: 809 CDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEPQRCF---------VWDGNS- 858
Query: 3087 IITGSQDGMVRVWKTEDVKMS 3107
+++GSQ G + VW K+S
Sbjct: 859 VLSGSQSGELLVWDLLGAKIS 879
Score = 37.7 bits (86), Expect = 0.18
Identities = 18/67 (26%), Positives = 35/67 (52%), Gaps = 7/67 (10%)
Query: 2947 TIVTSGTSTVVCVWELSMTKGRPRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTC 3006
++++ S + VW+L G ++ + + GHT AVTC+ + S +++G +D
Sbjct: 858 SVLSGSQSGELLVWDLL-------GAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQI 910
Query: 3007 ILWDLDH 3013
I W L +
Sbjct: 911 IFWKLQY 917
>gi|221625547 neutral sphingomyelinase (N-SMase) activation associated
factor isoform 2 [Homo sapiens]
Length = 948
Score = 273 bits (698), Expect = 2e-72
Identities = 215/681 (31%), Positives = 328/681 (48%), Gaps = 80/681 (11%)
Query: 2467 DMRELRQARFLLQDIALEIFFHNG---YSKFLVFYN-NDRSKAFKSFCSFQPSLKGKATS 2522
D+R + + R L + LE+F +L FY DR + ++ + T+
Sbjct: 270 DVRRIYKRRHGLMPLGLEVFCTEDDLCSDIYLKFYEPQDRDDLYFYIATYLEHHVAEHTA 329
Query: 2523 EDTLSLRRYPGSDRIMLQKWQKRDISNFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTS 2582
E MLQ WQ+ +SN++YL++LN A R+CND QYPVFPW++ DY+S
Sbjct: 330 ES------------YMLQ-WQRGHLSNYQYLLHLNNLADRSCNDLSQYPVFPWIIHDYSS 376
Query: 2583 ETLNLANPKIFRDLSKPMGAQTKERKLKFIQRFKEVEKTEGDMTVQCHYYTHYSSAIIVA 2642
L+L+NP FRDLSKP+GA KER + + R++E+ + + Y +HYSS V
Sbjct: 377 SELDLSNPGTFRDLSKPVGALNKERLERLLTRYQEMPEPK------FMYGSHYSSPGYVL 430
Query: 2643 SYLVRMPPFTQAFCALQGGSFDVADRMFHSVKSTWESASRENMSDVRELTPEFFYLP-EF 2701
YLVR+ P + LQ G FD ADRMF+S+ TW++ + +D +EL PEF+ F
Sbjct: 431 FYLVRIAP--EYMLCLQNGRFDNADRMFNSIAETWKNCL-DGATDFKELIPEFYGDDVSF 487
Query: 2702 LTNCNGVEFGCMQDGTVLGDVQLPPWADGDPRKFISLHRKALESDFVSANLHHWIDLIFG 2761
L N ++ G Q G ++ DV+LPPWA P F+ + ALES++VS +LH WIDLIFG
Sbjct: 488 LVNSLKLDLGKRQGGQMVDDVELPPWASS-PEDFLQKSKDALESNYVSEHLHEWIDLIFG 546
Query: 2762 YKQQGPAAVDAVNIFHPYFYGDRMDLSSITDPLIKSTILGFVSNFGQVPKQLFTKPHPAR 2821
YKQ+G AV A N+FHP Y +DL+SI DP K +L + FGQ PKQLF PHP R
Sbjct: 547 YKQKGSDAVGAHNVFHPLTYEGGVDLNSIQDPDEKVAMLTQILEFGQTPKQLFVTPHPRR 606
Query: 2822 TAAGKPLPGKDVSTPVSLPGHP-QPFFYSL----QSLRPSQVTVKDMY-LFSLGSE---- 2871
+ S S+ P + F L ++L + +T ++ + + E
Sbjct: 607 ITPKFKSLSQTSSYNASMADSPGEESFEDLTEESKTLAWNNITKLQLHEHYKIHKEAVTG 666
Query: 2872 ---SPKGAIGHIVSTEKTILAVERNKVLLPPLWNRTFSWGFDDFSCCLGSYGSDKVLMT- 2927
S G+ S + T+ + +L R+ S+ S CL G V+ +
Sbjct: 667 ITVSRNGSSVFTTSQDSTLKMFSKESKML----QRSISFSNMALSSCLLLPGDATVITSS 722
Query: 2928 -----FENLAAWGR----------CLCAVCPSPTTIVTSGTSTVVCVW-----ELSMTKG 2967
+ A+GR + +C + ++ + V VW E+ TK
Sbjct: 723 WDNNVYFYSIAFGRRQDTLMGHDDAVSKICWHDNRLYSASWDSTVKVWSGVPAEMPGTKR 782
Query: 2968 RPRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGI 3027
L A H +V ++ + +LLVSG+++ T +WDL T + ++P H +
Sbjct: 783 HHFDL---LAELEHDVSVDTISLNAASTLLVSGTKEGTVNIWDLTTATLMHQIPCHSGIV 839
Query: 3028 SAITISDVSGTIVSC-AGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQI 3086
S S ++S L++ +V L S T+ P+ WD +
Sbjct: 840 CDTAFSPDSRHVLSTGTDGCLNVIDVQTGMLISSMTSDEPQRCF---------VWDGNS- 889
Query: 3087 IITGSQDGMVRVWKTEDVKMS 3107
+++GSQ G + VW K+S
Sbjct: 890 VLSGSQSGELLVWDLLGAKIS 910
Score = 37.7 bits (86), Expect = 0.18
Identities = 18/67 (26%), Positives = 35/67 (52%), Gaps = 7/67 (10%)
Query: 2947 TIVTSGTSTVVCVWELSMTKGRPRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTC 3006
++++ S + VW+L G ++ + + GHT AVTC+ + S +++G +D
Sbjct: 889 SVLSGSQSGELLVWDLL-------GAKISERIQGHTGAVTCIWMNEQCSSIITGGEDRQI 941
Query: 3007 ILWDLDH 3013
I W L +
Sbjct: 942 IFWKLQY 948
>gi|239756689 PREDICTED: WD repeat domain 81 [Homo sapiens]
Length = 1941
Score = 89.7 bits (221), Expect = 4e-17
Identities = 91/305 (29%), Positives = 120/305 (39%), Gaps = 64/305 (20%)
Query: 2536 RIMLQKWQKRDISNFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRD 2595
R ++ W ISNF YLM LN AGR D +PV PWV+ D+T+ FRD
Sbjct: 346 RSLVLDWVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVV-DFTTPHGR------FRD 398
Query: 2596 LSKPMGAQTK-ERKLKFI-----QRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMP 2649
L K K +++L F Q F G+ H+ + S I Y R
Sbjct: 399 LRKSKFRLNKGDKQLDFTYEMTRQAFVAGGAGGGEPPHVPHHISDVLSDITYYVYKARRT 458
Query: 2650 PFTQAFCALQGGSFDVADRMFHSVKSTWES----ASRENMSDVR--ELTPEFFYLPEFLT 2703
P C V++ WE AS E M + E PEF+ P
Sbjct: 459 P-RSVLCG--------------HVRAQWEPHEYPASMERMQNWTPDECIPEFYTDPSIFR 503
Query: 2704 NCNGVEFGCMQDGTVLGDVQLPPWADGDPRKFISLHRKALESDFVSANLHHWIDLIFGYK 2763
+ + + D+ +P W ++F++ HR LES VS +LHHWIDL FGYK
Sbjct: 504 SIH----------PDMPDLDVPAWCSSS-QEFVAAHRALLESREVSRDLHHWIDLTFGYK 552
Query: 2764 QQGPAAVDAVNIFHPYFYGDRMDLSSITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTA 2823
QG AV N+ + D G V QLF +PHP R A
Sbjct: 553 LQGKEAVKEKNV-----------CLHLVDAHTHLASYGVV--------QLFDQPHPQRLA 593
Query: 2824 AGKPL 2828
L
Sbjct: 594 GAPAL 598
Score = 35.4 bits (80), Expect = 0.91
Identities = 25/83 (30%), Positives = 40/83 (48%), Gaps = 8/83 (9%)
Query: 2976 QALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPA-------HREGIS 3028
Q+ GH+ AV C+A + +SGS+D T LW L + T A HR+ +
Sbjct: 1642 QSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLYNYGDGTSETAPRLVYTQHRKSVF 1701
Query: 3029 AITISDVSGTIVSCAGAHLSLWN 3051
+ + +VSC GA + +W+
Sbjct: 1702 FVGQLEAPQHVVSCDGA-VHVWD 1723
>gi|239751186 PREDICTED: WD repeat domain 81 [Homo sapiens]
Length = 2240
Score = 89.7 bits (221), Expect = 4e-17
Identities = 91/305 (29%), Positives = 120/305 (39%), Gaps = 64/305 (20%)
Query: 2536 RIMLQKWQKRDISNFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRD 2595
R ++ W ISNF YLM LN AGR D +PV PWV+ D+T+ FRD
Sbjct: 645 RSLVLDWVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVV-DFTTPHGR------FRD 697
Query: 2596 LSKPMGAQTK-ERKLKFI-----QRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMP 2649
L K K +++L F Q F G+ H+ + S I Y R
Sbjct: 698 LRKSKFRLNKGDKQLDFTYEMTRQAFVAGGAGGGEPPHVPHHISDVLSDITYYVYKARRT 757
Query: 2650 PFTQAFCALQGGSFDVADRMFHSVKSTWES----ASRENMSDVR--ELTPEFFYLPEFLT 2703
P C V++ WE AS E M + E PEF+ P
Sbjct: 758 P-RSVLCG--------------HVRAQWEPHEYPASMERMQNWTPDECIPEFYTDPSIFR 802
Query: 2704 NCNGVEFGCMQDGTVLGDVQLPPWADGDPRKFISLHRKALESDFVSANLHHWIDLIFGYK 2763
+ + + D+ +P W ++F++ HR LES VS +LHHWIDL FGYK
Sbjct: 803 SIH----------PDMPDLDVPAWCSSS-QEFVAAHRALLESREVSRDLHHWIDLTFGYK 851
Query: 2764 QQGPAAVDAVNIFHPYFYGDRMDLSSITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTA 2823
QG AV N+ + D G V QLF +PHP R A
Sbjct: 852 LQGKEAVKEKNV-----------CLHLVDAHTHLASYGVV--------QLFDQPHPQRLA 892
Query: 2824 AGKPL 2828
L
Sbjct: 893 GAPAL 897
Score = 35.4 bits (80), Expect = 0.91
Identities = 25/83 (30%), Positives = 40/83 (48%), Gaps = 8/83 (9%)
Query: 2976 QALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPA-------HREGIS 3028
Q+ GH+ AV C+A + +SGS+D T LW L + T A HR+ +
Sbjct: 1941 QSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLYNYGDGTSETAPRLVYTQHRKSVF 2000
Query: 3029 AITISDVSGTIVSCAGAHLSLWN 3051
+ + +VSC GA + +W+
Sbjct: 2001 FVGQLEAPQHVVSCDGA-VHVWD 2022
>gi|239745674 PREDICTED: WD repeat domain 81 [Homo sapiens]
Length = 1941
Score = 89.7 bits (221), Expect = 4e-17
Identities = 91/305 (29%), Positives = 120/305 (39%), Gaps = 64/305 (20%)
Query: 2536 RIMLQKWQKRDISNFEYLMYLNTAAGRTCNDYMQYPVFPWVLADYTSETLNLANPKIFRD 2595
R ++ W ISNF YLM LN AGR D +PV PWV+ D+T+ FRD
Sbjct: 346 RSLVLDWVHGRISNFHYLMQLNRLAGRRQGDPNYHPVLPWVV-DFTTPHGR------FRD 398
Query: 2596 LSKPMGAQTK-ERKLKFI-----QRFKEVEKTEGDMTVQCHYYTHYSSAIIVASYLVRMP 2649
L K K +++L F Q F G+ H+ + S I Y R
Sbjct: 399 LRKSKFRLNKGDKQLDFTYEMTRQAFVAGGAGGGEPPHVPHHISDVLSDITYYVYKARRT 458
Query: 2650 PFTQAFCALQGGSFDVADRMFHSVKSTWES----ASRENMSDVR--ELTPEFFYLPEFLT 2703
P C V++ WE AS E M + E PEF+ P
Sbjct: 459 P-RSVLCG--------------HVRAQWEPHEYPASMERMQNWTPDECIPEFYTDPSIFR 503
Query: 2704 NCNGVEFGCMQDGTVLGDVQLPPWADGDPRKFISLHRKALESDFVSANLHHWIDLIFGYK 2763
+ + + D+ +P W ++F++ HR LES VS +LHHWIDL FGYK
Sbjct: 504 SIH----------PDMPDLDVPAWCSSS-QEFVAAHRALLESREVSRDLHHWIDLTFGYK 552
Query: 2764 QQGPAAVDAVNIFHPYFYGDRMDLSSITDPLIKSTILGFVSNFGQVPKQLFTKPHPARTA 2823
QG AV N+ + D G V QLF +PHP R A
Sbjct: 553 LQGKEAVKEKNV-----------CLHLVDAHTHLASYGVV--------QLFDQPHPQRLA 593
Query: 2824 AGKPL 2828
L
Sbjct: 594 GAPAL 598
Score = 35.4 bits (80), Expect = 0.91
Identities = 25/83 (30%), Positives = 40/83 (48%), Gaps = 8/83 (9%)
Query: 2976 QALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPA-------HREGIS 3028
Q+ GH+ AV C+A + +SGS+D T LW L + T A HR+ +
Sbjct: 1642 QSFPGHSGAVKCVAPLSSEDFFLSGSKDRTVRLWPLYNYGDGTSETAPRLVYTQHRKSVF 1701
Query: 3029 AITISDVSGTIVSCAGAHLSLWN 3051
+ + +VSC GA + +W+
Sbjct: 1702 FVGQLEAPQHVVSCDGA-VHVWD 1723
>gi|31317270 WD repeat and FYVE domain containing 3 isoform 3 [Homo
sapiens]
Length = 281
Score = 55.5 bits (132), Expect = 8e-07
Identities = 23/56 (41%), Positives = 36/56 (64%)
Query: 3126 GHKWEKNLALSRELDVSIALTGKPSKTSPAVTALAVSRNHTKLLVGDERGRIFCWS 3181
G++WE+ L +L + A K + VTAL +S++H+++LVGD RGR+F WS
Sbjct: 138 GYRWERQLVFRSKLTMHTAFDRKDNAHPAEVTALGISKDHSRILVGDSRGRVFSWS 193
>gi|4505895 pleiotropic regulator 1 (PRL1 homolog, Arabidopsis) [Homo
sapiens]
Length = 514
Score = 53.5 bits (127), Expect = 3e-06
Identities = 44/168 (26%), Positives = 70/168 (41%), Gaps = 18/168 (10%)
Query: 2934 WGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGRPRGLRLRQALYGHTQAVTCLAASVT 2993
W RC+ AV P VT + +W+L+ K L+ +L GH V + S
Sbjct: 206 WVRCI-AVEPGNQWFVTGSADRTIKIWDLASGK-------LKLSLTGHISTVRGVIVSTR 257
Query: 2994 FSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGISAITISDVSGTIVSCA-GAHLSLWNV 3052
L S +D WDL++ + H + + + +V+C+ + +W+V
Sbjct: 258 SPYLFSCGEDKQVKCWDLEYNKVIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDV 317
Query: 3053 NGQPLASITTAWGPEGAI-TCCCLMEGPAWDTSQIIITGSQDGMVRVW 3099
+ AS+ T G A+ T C P IITGS D +R+W
Sbjct: 318 RTK--ASVHTLSGHTNAVATVRCQAAEPQ------IITGSHDTTIRLW 357
Score = 37.0 bits (84), Expect = 0.31
Identities = 38/164 (23%), Positives = 66/164 (40%), Gaps = 14/164 (8%)
Query: 2902 NRTFSWGFDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWE 2961
N+ F G D + + S K+ ++ + R + SP V C W+
Sbjct: 216 NQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIVSTRSPYLFSCGEDKQVKC-WD 274
Query: 2962 LSMTKGRPRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLP 3021
L K + + +GH AV L T +LV+ S+D T +WD+ V L
Sbjct: 275 LEYNK-------VIRHYHGHLSAVYGLDLHPTIDVLVTCSRDSTARIWDVRTKASVHTLS 327
Query: 3022 AHREGISAITISDVSGTIVSCAGAH---LSLWN-VNGQPLASIT 3061
H ++ + I++ G+H + LW+ V G+ ++T
Sbjct: 328 GHTNAVATVRCQAAEPQIIT--GSHDTTIRLWDLVAGKTRVTLT 369
Score = 35.8 bits (81), Expect = 0.70
Identities = 31/128 (24%), Positives = 51/128 (39%), Gaps = 8/128 (6%)
Query: 2973 RLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGISAITI 3032
+L + + GH V C+A V+GS D T +WDL L H + + +
Sbjct: 195 KLYRVISGHLGWVRCIAVEPGNQWFVTGSADRTIKIWDLASGKLKLSLTGHISTVRGVIV 254
Query: 3033 SDVSGTIVSCA-GAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIIITGS 3091
S S + SC + W++ + I G A+ L T +++T S
Sbjct: 255 STRSPYLFSCGEDKQVKCWDLEYNKV--IRHYHGHLSAVYGLDL-----HPTIDVLVTCS 307
Query: 3092 QDGMVRVW 3099
+D R+W
Sbjct: 308 RDSTARIW 315
>gi|11055998 guanine nucleotide-binding protein, beta-4 subunit [Homo
sapiens]
Length = 340
Score = 52.8 bits (125), Expect = 5e-06
Identities = 32/115 (27%), Positives = 54/115 (46%), Gaps = 5/115 (4%)
Query: 2939 CAVCPSPTTIVTSGTSTVVCVWELSMTKGRPRGLRLRQALYGHTQAVTCLAASVTFSLLV 2998
CA PS + G + ++ L +G +R+ + L GHT ++C + S +V
Sbjct: 103 CAYAPSGNYVACGGLDNICSIYNLKTREGN---VRVSRELPGHTGYLSC-CRFLDDSQIV 158
Query: 2999 SGSQDCTCILWDLDHLTHVTRLPAHREGISAITISDVSGTIVSCA-GAHLSLWNV 3052
+ S D TC LWD++ T H + ++++S T VS A A LW++
Sbjct: 159 TSSGDTTCALWDIETAQQTTTFTGHSGDVMSLSLSPDMRTFVSGACDASSKLWDI 213
Score = 41.2 bits (95), Expect = 0.017
Identities = 36/140 (25%), Positives = 58/140 (41%), Gaps = 11/140 (7%)
Query: 2972 LRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGISAIT 3031
+R R+ L GH + + LLVS SQD I+WD + +P +
Sbjct: 45 MRTRRTLRGHLAKIYAMHWGYDSRLLVSASQDGKLIIWDSYTTNKMHAIPLRSSWVMTCA 104
Query: 3032 ISDVSGTIVSCAGAH--LSLWNVNGQP--LASITTAWGPEGAITCCCLMEGPAWDTSQII 3087
+ SG V+C G S++N+ + + G G ++CC + D SQ I
Sbjct: 105 YAP-SGNYVACGGLDNICSIYNLKTREGNVRVSRELPGHTGYLSCCRFL-----DDSQ-I 157
Query: 3088 ITGSQDGMVRVWKTEDVKMS 3107
+T S D +W E + +
Sbjct: 158 VTSSGDTTCALWDIETAQQT 177
Score = 33.5 bits (75), Expect = 3.4
Identities = 35/165 (21%), Positives = 65/165 (39%), Gaps = 21/165 (12%)
Query: 2940 AVCPSPTTIVTSGTSTVVCVWELSMTKGRPRGLRLRQALYGHTQAVTCLAASVTFSLLVS 2999
++ P T V+ +W++ R RQ+ GH + ++ +
Sbjct: 191 SLSPDMRTFVSGACDASSKLWDI-------RDGMCRQSFTGHVSDINAVSFFPNGYAFAT 243
Query: 3000 GSQDCTCILWDLDHLTHVTRLPAHRE---GISAITISDVSGTIVSCA--GAHLSLWNVNG 3054
GS D TC L+DL L +H GI+++ S SG ++ + ++W+
Sbjct: 244 GSDDATCRLFDL-RADQELLLYSHDNIICGITSVAFSK-SGRLLLAGYDDFNCNVWDTLK 301
Query: 3055 QPLASITTAWGPEGAITCCCLMEGPAWDTSQIIITGSQDGMVRVW 3099
A + G + ++C + D + TGS D +R+W
Sbjct: 302 GDRAGVLA--GHDNRVSCLGVT-----DDGMAVATGSWDSFLRIW 339
>gi|11321585 guanine nucleotide-binding protein, beta-1 subunit [Homo
sapiens]
Length = 340
Score = 52.0 bits (123), Expect = 9e-06
Identities = 40/162 (24%), Positives = 67/162 (41%), Gaps = 12/162 (7%)
Query: 2939 CAVCPSPTTIVTSGTSTVVCVWELSMTKGRPRGLRLRQALYGHTQAVTCLAASVTFSLLV 2998
CA PS + G + ++ L +G +R+ + L GHT ++C + + +V
Sbjct: 103 CAYAPSGNYVACGGLDNICSIYNLKTREGN---VRVSRELAGHTGYLSC-CRFLDDNQIV 158
Query: 2999 SGSQDCTCILWDLDHLTHVTRLPAHREGISAITISDVSGTIVSCA-GAHLSLWNVNGQPL 3057
+ S D TC LWD++ T H + +++++ + VS A A LW+V
Sbjct: 159 TSSGDTTCALWDIETGQQTTTFTGHTGDVMSLSLAPDTRLFVSGACDASAKLWDVREGMC 218
Query: 3058 ASITTAWGPEGAITCCCLMEGPAWDTSQIIITGSQDGMVRVW 3099
T G E I C + TGS D R++
Sbjct: 219 RQTFT--GHESDINAICF-----FPNGNAFATGSDDATCRLF 253
Score = 43.1 bits (100), Expect = 0.004
Identities = 39/136 (28%), Positives = 57/136 (41%), Gaps = 13/136 (9%)
Query: 2972 LRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGISAIT 3031
+R R+ L GH + + LLVS SQD I+WD V +P +
Sbjct: 45 MRTRRTLRGHLAKIYAMHWGTDSRLLVSASQDGKLIIWDSYTTNKVHAIPLRSSWVMTCA 104
Query: 3032 ISDVSGTIVSCAGAH--LSLWNV---NGQPLASITTAWGPEGAITCCCLMEGPAWDTSQI 3086
+ SG V+C G S++N+ G S A G G ++CC + D +Q
Sbjct: 105 YAP-SGNYVACGGLDNICSIYNLKTREGNVRVSRELA-GHTGYLSCCRFL-----DDNQ- 156
Query: 3087 IITGSQDGMVRVWKTE 3102
I+T S D +W E
Sbjct: 157 IVTSSGDTTCALWDIE 172
>gi|89886480 zinedin isoform 2 [Homo sapiens]
Length = 760
Score = 51.2 bits (121), Expect = 2e-05
Identities = 34/96 (35%), Positives = 48/96 (50%), Gaps = 13/96 (13%)
Query: 2962 LSMTKGRPRGLRLRQ--------ALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDH 3013
L++T RG+R ++ H AVTCLA + L+SGS DC+ LW LD+
Sbjct: 658 LTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDN 717
Query: 3014 LTHVTRLPAHR----EGISAITISDVSGTIVSCAGA 3045
T V + AHR E I A+ S +++ AGA
Sbjct: 718 KTCVQEITAHRKKHEEAIHAVACHP-SKALIASAGA 752
>gi|89886477 zinedin isoform 1 [Homo sapiens]
Length = 753
Score = 51.2 bits (121), Expect = 2e-05
Identities = 34/96 (35%), Positives = 48/96 (50%), Gaps = 13/96 (13%)
Query: 2962 LSMTKGRPRGLRLRQ--------ALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDH 3013
L++T RG+R ++ H AVTCLA + L+SGS DC+ LW LD+
Sbjct: 651 LTITAHDDRGIRFLDNRTGKPVHSMVAHLDAVTCLAVDPNGAFLMSGSHDCSLRLWSLDN 710
Query: 3014 LTHVTRLPAHR----EGISAITISDVSGTIVSCAGA 3045
T V + AHR E I A+ S +++ AGA
Sbjct: 711 KTCVQEITAHRKKHEEAIHAVACHP-SKALIASAGA 745
>gi|23199987 WD repeat domain 5B [Homo sapiens]
Length = 330
Score = 50.8 bits (120), Expect = 2e-05
Identities = 40/159 (25%), Positives = 70/159 (44%), Gaps = 17/159 (10%)
Query: 2943 PSPTTIVTSGTSTVVCVWELSMTKGRPRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQ 3002
P+ + +S ++ +W G G + + LYGH ++ +A S S LVS S
Sbjct: 51 PNGEWLASSSADRLIIIW------GAYDG-KYEKTLYGHNLEISDVAWSSDSSRLVSASD 103
Query: 3003 DCTCILWDLDHLTHVTRLPAHREGISAITISDVSGTIVSCA-GAHLSLWNV-NGQPLASI 3060
D T LWD+ + L H + + S I+S + + +W V G+ L ++
Sbjct: 104 DKTLKLWDVRSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVKIWEVKTGKCLKTL 163
Query: 3061 TTAWGPEGAITCCCLMEGPAWDTSQIIITGSQDGMVRVW 3099
+ P A+ C + +I++GS DG+ R+W
Sbjct: 164 SAHSDPVSAVHFNC--------SGSLIVSGSYDGLCRIW 194
Score = 47.0 bits (110), Expect = 3e-04
Identities = 39/133 (29%), Positives = 57/133 (42%), Gaps = 8/133 (6%)
Query: 2974 LRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGISAITIS 3033
L+ L GHT+AV+ + S L S S D I+W + L H IS + S
Sbjct: 33 LKCTLVGHTEAVSSVKFSPNGEWLASSSADRLIIIWGAYDGKYEKTLYGHNLEISDVAWS 92
Query: 3034 DVSGTIVSCA-GAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIIITGSQ 3092
S +VS + L LW+V + T G + CC S +II+GS
Sbjct: 93 SDSSRLVSASDDKTLKLWDVRSG--KCLKTLKGHSNYVFCCNFN-----PPSNLIISGSF 145
Query: 3093 DGMVRVWKTEDVK 3105
D V++W+ + K
Sbjct: 146 DETVKIWEVKTGK 158
Score = 45.1 bits (105), Expect = 0.001
Identities = 49/206 (23%), Positives = 88/206 (42%), Gaps = 18/206 (8%)
Query: 2910 DDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKGRP 2969
DD + L S K L T + + + C C P I++ V +WE+ K
Sbjct: 103 DDKTLKLWDVRSGKCLKTLKGHSNYVFC-CNFNPPSNLIISGSFDETVKIWEVKTGK--- 158
Query: 2970 RGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHV-TRLPAHREGIS 3028
+ L H+ V+ + + + SL+VSGS D C +WD + T + +S
Sbjct: 159 ----CLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDNPPVS 214
Query: 3029 AITISDVSGTIVSCAGAH-LSLWNVN-GQPLASITTAWGPEGAITCCCLMEGPAWDTSQI 3086
+ S I++ + L LW+ + G+ L + T + I + G W
Sbjct: 215 FVKFSPNGKYILTATLDNTLKLWDYSRGRCLKTYTGHKNEKYCIFANFSVTGGKW----- 269
Query: 3087 IITGSQDGMVRVW--KTEDVKMSVPG 3110
I++GS+D +V +W +T+++ + G
Sbjct: 270 IVSGSEDNLVYIWNLQTKEIVQKLQG 295
Score = 35.8 bits (81), Expect = 0.70
Identities = 33/154 (21%), Positives = 68/154 (44%), Gaps = 16/154 (10%)
Query: 2948 IVTSGTSTVVCVWELSMTKGRPRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCI 3007
+V++ + +W++ R + + L GH+ V C + +L++SGS D T
Sbjct: 98 LVSASDDKTLKLWDV-------RSGKCLKTLKGHSNYVFCCNFNPPSNLIISGSFDETVK 150
Query: 3008 LWDLDHLTHVTRLPAHREGISAITISDVSGTIVSCAGAHL-SLWN-VNGQPLASITTAWG 3065
+W++ + L AH + +SA+ + IVS + L +W+ +GQ L ++
Sbjct: 151 IWEVKTGKCLKTLSAHSDPVSAVHFNCSGSLIVSGSYDGLCRIWDAASGQCLKTLVDDDN 210
Query: 3066 PEGAITCCCLMEGPAWDTSQIIITGSQDGMVRVW 3099
P + + I+T + D +++W
Sbjct: 211 PPVSFV-------KFSPNGKYILTATLDNTLKLW 237
>gi|5174447 guanine nucleotide binding protein (G protein), beta
polypeptide 2-like 1 [Homo sapiens]
Length = 317
Score = 50.4 bits (119), Expect = 3e-05
Identities = 57/227 (25%), Positives = 93/227 (40%), Gaps = 38/227 (16%)
Query: 2882 STEKTILAVERNKVLLPPLWNRTFSWGFDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAV 2941
S + I++ R+K + LWN + G K + E+ + W C+
Sbjct: 115 SDNRQIVSGSRDKTI--KLWN---------------TLGVCKYTVQDESHSEWVSCVRFS 157
Query: 2942 CPSPTTIVTS-GTSTVVCVWELSMTKGRPRGLRLRQALYGHTQAVTCLAASVTFSLLVSG 3000
S I+ S G +V VW L+ K L+ GHT + + S SL SG
Sbjct: 158 PNSSNPIIVSCGWDKLVKVWNLANCK-------LKTNHIGHTGYLNTVTVSPDGSLCASG 210
Query: 3001 SQDCTCILWDLDHLTHVTRLPAHREGISAITISDVSGTIVSCAGAHLSLWNVNGQPLAS- 3059
+D +LWDL+ H+ L + I+A+ S + + G + +W++ G+ +
Sbjct: 211 GKDGQAMLWDLNEGKHLYTLDG-GDIINALCFSPNRYWLCAATGPSIKIWDLEGKIIVDE 269
Query: 3060 -----ITTAWGPEGAITCCCLMEGPAWDT-SQIIITGSQDGMVRVWK 3100
I+T+ E C L AW Q + G D +VRVW+
Sbjct: 270 LKQEVISTSSKAEPP-QCTSL----AWSADGQTLFAGYTDNLVRVWQ 311
Score = 48.5 bits (114), Expect = 1e-04
Identities = 44/184 (23%), Positives = 77/184 (41%), Gaps = 13/184 (7%)
Query: 2927 TFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTK---GRPRGLRLRQALYGHTQ 2983
T + W + P I+++ + +W+L+ + G P+ +AL GH+
Sbjct: 10 TLKGHNGWVTQIATTPQFPDMILSASRDKTIIMWKLTRDETNYGIPQ-----RALRGHSH 64
Query: 2984 AVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGISAITISDVSGTIVS-C 3042
V+ + S +SGS D T LWDL T R H + + ++ S + IVS
Sbjct: 65 FVSDVVISSDGQFALSGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNRQIVSGS 124
Query: 3043 AGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIIITGSQDGMVRVWKTE 3102
+ LWN G ++ E C+ P ++ II++ D +V+VW
Sbjct: 125 RDKTIKLWNTLGVCKYTVQDESHSEWV---SCVRFSPN-SSNPIIVSCGWDKLVKVWNLA 180
Query: 3103 DVKM 3106
+ K+
Sbjct: 181 NCKL 184
>gi|62234461 Notchless gene homolog isoform a [Homo sapiens]
Length = 485
Score = 50.1 bits (118), Expect = 4e-05
Identities = 40/130 (30%), Positives = 56/130 (43%), Gaps = 2/130 (1%)
Query: 2973 RLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGISAITI 3032
R +L GH++AV +A S T L SGS D T WDL T HR + +I+
Sbjct: 105 RCTSSLEGHSEAVISVAFSPTGKYLASGSGDTTVRFWDLSTETPHFTCKGHRHWVLSISW 164
Query: 3033 SDVSGTIVS-CAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIIITGS 3091
S + S C + LW+ + T A G IT A + + + S
Sbjct: 165 SPDGRKLASGCKNGQILLWDPSTGKQVGRTLA-GHSKWITGLSWEPLHANPECRYVASSS 223
Query: 3092 QDGMVRVWKT 3101
+DG VR+W T
Sbjct: 224 KDGSVRIWDT 233
Score = 43.5 bits (101), Expect = 0.003
Identities = 40/138 (28%), Positives = 66/138 (47%), Gaps = 17/138 (12%)
Query: 2997 LVSGSQDCTCILWD-LDHLTHVTRLPAHREGISAITISDVSGTIVSCA-GAHLSLWNVN- 3053
LVSGS D T LW + +TR+ H+ I+ + S S + S + + LW+
Sbjct: 344 LVSGSDDFTLFLWSPAEDKKPLTRMTGHQALINQVLFSPDSRIVASASFDKSIKLWDGRT 403
Query: 3054 GQPLASITTAWGPEGAITCCCLMEGPAWDT-SQIIITGSQDGMVRVW--KTEDVKMSVPG 3110
G+ LAS+ G + + AW S+++++GS D ++VW K + + M +PG
Sbjct: 404 GKYLASL------RGHVAAVYQI---AWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPG 454
Query: 3111 RPAGEEPPAQPPSPRGHK 3128
+E A SP G +
Sbjct: 455 H--ADEVYAVDWSPDGQR 470
Score = 42.0 bits (97), Expect = 0.010
Identities = 36/123 (29%), Positives = 54/123 (43%), Gaps = 7/123 (5%)
Query: 2908 GFDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKG 2967
G DDF+ L S DK +T + + V SP + + + S ++ S+
Sbjct: 347 GSDDFTLFLWSPAEDKKPLT--RMTGHQALINQVLFSPDSRIVASAS-----FDKSIKLW 399
Query: 2968 RPRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGI 3027
R + +L GH AV +A S LLVSGS D T +WD+ LP H + +
Sbjct: 400 DGRTGKYLASLRGHVAAVYQIAWSADSRLLVSGSSDSTLKVWDVKAQKLAMDLPGHADEV 459
Query: 3028 SAI 3030
A+
Sbjct: 460 YAV 462
Score = 32.7 bits (73), Expect = 5.9
Identities = 27/91 (29%), Positives = 38/91 (41%), Gaps = 8/91 (8%)
Query: 2943 PSPTTIVTSGTSTVVCVWELSMTKGRPRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQ 3002
P + +S V +W+ T GR + L GHTQ+VTCL LL S SQ
Sbjct: 214 PECRYVASSSKDGSVRIWDT--TAGR-----CERILTGHTQSVTCLRWGGD-GLLYSASQ 265
Query: 3003 DCTCILWDLDHLTHVTRLPAHREGISAITIS 3033
D T +W L H ++ + +S
Sbjct: 266 DRTIKVWRAHDGVLCRTLQGHGHWVNTMALS 296
Score = 32.7 bits (73), Expect = 5.9
Identities = 30/131 (22%), Positives = 50/131 (38%), Gaps = 26/131 (19%)
Query: 2980 GHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGISAITISDVSGTI 3039
GH + + S ++ S S D + LWD ++ L H + I S S +
Sbjct: 370 GHQALINQVLFSPDSRIVASASFDKSIKLWDGRTGKYLASLRGHVAAVYQIAWSADSRLL 429
Query: 3040 VS-CAGAHLSLWNVNGQPLAS---------ITTAWGPEGAITCCCLMEGPAWDTSQIIIT 3089
VS + + L +W+V Q LA W P+G Q + +
Sbjct: 430 VSGSSDSTLKVWDVKAQKLAMDLPGHADEVYAVDWSPDG----------------QRVAS 473
Query: 3090 GSQDGMVRVWK 3100
G +D +R+W+
Sbjct: 474 GGKDKCLRIWR 484
>gi|18874090 WD repeat domain 48 [Homo sapiens]
Length = 677
Score = 49.7 bits (117), Expect = 5e-05
Identities = 53/219 (24%), Positives = 90/219 (41%), Gaps = 27/219 (12%)
Query: 2893 NKVLLPPLWNRTFSWGFDDFS--CCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVT 2950
N + L P NR F+ G D + + D + + E+ W + +C + T+++
Sbjct: 34 NALQLDPALNRLFTAGRDSIIRIWSVNQHKQDPYIASMEHHTDWVNDI-VLCCNGKTLIS 92
Query: 2951 SGTSTVVCVWELSMTKGRPRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWD 3010
+ + T V VW +G + L H V LA + L+ S D LWD
Sbjct: 93 ASSDTTVKVWNAH------KGFCM-STLRTHKDYVKALAYAKDKELVASAGLDRQIFLWD 145
Query: 3011 LDHLTHVTRLPAHREGISAITISDVSGTIVSCAGAHLSLWNVNGQPLASITTAWGPEGAI 3070
++ LT +T A ++ ++S +I S A L V+G + W P
Sbjct: 146 VNTLTALT---ASNNTVTTSSLSGNKDSIYSLAMNQLGTIIVSGST-EKVLRVWDPR--- 198
Query: 3071 TCCCLME--GPAWDTSQIII--------TGSQDGMVRVW 3099
TC LM+ G + +++ +GS DG +R+W
Sbjct: 199 TCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGTIRLW 237
Score = 42.7 bits (99), Expect = 0.006
Identities = 28/89 (31%), Positives = 39/89 (43%), Gaps = 7/89 (7%)
Query: 2946 TTIVTSGTSTVVCVWELSMTKGRPRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCT 3005
T IV+ T V+ VW+ PR L GHT V L + + +SGS D T
Sbjct: 181 TIIVSGSTEKVLRVWD-------PRTCAKLMKLKGHTDNVKALLLNRDGTQCLSGSSDGT 233
Query: 3006 CILWDLDHLTHVTRLPAHREGISAITISD 3034
LW L + H EG+ A+ ++D
Sbjct: 234 IRLWSLGQQRCIATYRVHDEGVWALQVND 262
>gi|4557741 platelet-activating factor acetylhydrolase, isoform Ib,
alpha subunit [Homo sapiens]
Length = 410
Score = 49.3 bits (116), Expect = 6e-05
Identities = 32/129 (24%), Positives = 57/129 (44%), Gaps = 8/129 (6%)
Query: 2975 RQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGISAITISD 3034
+ AL GH VT + FS++VS S+D T +WD + L H + + I+
Sbjct: 101 KYALSGHRSPVTRVIFHPVFSVMVSASEDATIKVWDYETGDFERTLKGHTDSVQDISFDH 160
Query: 3035 VSGTIVSC-AGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIIITGSQD 3093
+ SC A + LW+ G I T G + ++ +M I++ S+D
Sbjct: 161 SGKLLASCSADMTIKLWDFQG--FECIRTMHGHDHNVSSVAIM-----PNGDHIVSASRD 213
Query: 3094 GMVRVWKTE 3102
+++W+ +
Sbjct: 214 KTIKMWEVQ 222
Score = 37.4 bits (85), Expect = 0.24
Identities = 32/163 (19%), Positives = 65/163 (39%), Gaps = 14/163 (8%)
Query: 2951 SGTSTVVCVWELSMTKGRPRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQDCTCILWD 3010
SG C ++++ +G + ++GH V+ +A +VS S+D T +W+
Sbjct: 161 SGKLLASCSADMTIKLWDFQGFECIRTMHGHDHNVSSVAIMPNGDHIVSASRDKTIKMWE 220
Query: 3011 LDHLTHVTRLPAHREGISAITISDVSGTIVSCAGAH-LSLWNVNGQPLAS---------I 3060
+ V HRE + + + I SC+ + +W V + +
Sbjct: 221 VQTGYCVKTFTGHREWVRMVRPNQDGTLIASCSNDQTVRVWVVATKECKAELREHEHVVE 280
Query: 3061 TTAWGPEGAITCCCLMEGPAWDTS----QIIITGSQDGMVRVW 3099
+W PE + + G S +++GS+D +++W
Sbjct: 281 CISWAPESSYSSISEATGSETKKSGKPGPFLLSGSRDKTIKMW 323
Score = 33.5 bits (75), Expect = 3.4
Identities = 27/105 (25%), Positives = 46/105 (43%), Gaps = 8/105 (7%)
Query: 2997 LVSGSQDCTCILWDLDHLTHVTRLPAHREGISAITISDVSGTIVSCA-GAHLSLWNVNGQ 3055
L+SGS+D T +WD+ + L H + + I+SCA L +W+ +
Sbjct: 311 LLSGSRDKTIKMWDVSTGMCLMTLVGHDNWVRGVLFHSGGKFILSCADDKTLRVWDYKNK 370
Query: 3056 PLASITTAWGPEGAITCCCLMEGPAWDTSQIIITGSQDGMVRVWK 3100
+ T E +T + T+ ++TGS D V+VW+
Sbjct: 371 --RCMKTLNAHEHFVTSLDFHK-----TAPYVVTGSVDQTVKVWE 408
>gi|113865883 WD repeat domain 38 [Homo sapiens]
Length = 314
Score = 49.3 bits (116), Expect = 6e-05
Identities = 53/229 (23%), Positives = 90/229 (39%), Gaps = 26/229 (11%)
Query: 2939 CAVCPSPTTIVTSGTSTVVCVWELSMTKGRPRGLRLRQALYGHTQAVTCLAASVTFSLLV 2998
C P ++ V +W+++ K + L GH ++V ++ S L
Sbjct: 69 CRFSPDGHLFASASCDCTVRLWDVARAK-------CLRVLKGHQRSVETVSFSPDSRQLA 121
Query: 2999 SGSQDCTCILWDLDHLTHVTRLPAHREGISAITISDVSGTIVSCA----GAHLSLWNVNG 3054
SG D +LWD+ + L HR+ I + SD S T+ A + + +W++
Sbjct: 122 SGGWDKRVMLWDVQSGQMLRLLVGHRDSIQS---SDFSPTVNCLATGSWDSTVHIWDLRM 178
Query: 3055 -QPLASITTAWGPEGAITCCCLMEGPAWDTSQIIITGSQDGMVRVWK--TEDVKMSVPGR 3111
P S G I+C C + S ++ +GS D + +WK T + + + G
Sbjct: 179 VTPAVSHQALEGHSANISCLC------YSASGLLASGSWDKTIHIWKPTTSSLLIQLKGH 232
Query: 3112 PAGEEPPAQPPSPRGHKWEKNLALSRELDVSIALTGKPSKTSPAVTALA 3160
+ A P W + SR + V TGK +T V +A
Sbjct: 233 VTWVKSIAFSPD---ELWLASAGYSRMVKVWDCNTGKCLETLKGVLDVA 278
Score = 42.7 bits (99), Expect = 0.006
Identities = 46/172 (26%), Positives = 65/172 (37%), Gaps = 20/172 (11%)
Query: 2940 AVCPSPTTIVTSGTSTVVCVWELSMTKGRPRGLRLRQALYGHTQAVTCLAASVTFSLLVS 2999
A P ++T V WE R +L L GHT V S L S
Sbjct: 28 AFSPDGQMLLTGSEDGCVYGWET-------RSGQLLWRLGGHTGPVKFCRFSPDGHLFAS 80
Query: 3000 GSQDCTCILWDLDHLTHVTRLPAHREGISAITISDVSGTIVSCA-GAHLSLWNV-NGQPL 3057
S DCT LWD+ + L H+ + ++ S S + S + LW+V +GQ L
Sbjct: 81 ASCDCTVRLWDVARAKCLRVLKGHQRSVETVSFSPDSRQLASGGWDKRVMLWDVQSGQML 140
Query: 3058 ASITTAWGPEGAITCCCLMEGPAWDTSQIIITGSQDGMVRVWKTEDVKMSVP 3109
+ G +I T + TGS D V +W D++M P
Sbjct: 141 RLLV---GHRDSI-----QSSDFSPTVNCLATGSWDSTVHIW---DLRMVTP 181
Score = 41.6 bits (96), Expect = 0.013
Identities = 41/155 (26%), Positives = 68/155 (43%), Gaps = 19/155 (12%)
Query: 2943 PSPTTIVTSGTSTVVCVWELSMTKGRPRGLRLRQALYGHTQAVTCLAASVTFSLLVSGSQ 3002
P+ + T + V +W+L M QAL GH+ ++CL S + LL SGS
Sbjct: 157 PTVNCLATGSWDSTVHIWDLRMVTPAVS----HQALEGHSANISCLCYSAS-GLLASGSW 211
Query: 3003 DCTCILWDLDHLTHVTRLPAHREGISAITISDVSGTIVSCAGAHL-SLWNVN-GQPLASI 3060
D T +W + + +L H + +I S + S + + +W+ N G+ L ++
Sbjct: 212 DKTIHIWKPTTSSLLIQLKGHVTWVKSIAFSPDELWLASAGYSRMVKVWDCNTGKCLETL 271
Query: 3061 --------TTAWGPEGAITCCCLMEGPAWDTSQII 3087
T A+ P+G I L+ G A T + I
Sbjct: 272 KGVLDVAHTCAFTPDGKI----LVSGAADQTRRQI 302
>gi|110815834 F-box and WD-40 domain protein 10 [Homo sapiens]
Length = 1051
Score = 49.3 bits (116), Expect = 6e-05
Identities = 35/120 (29%), Positives = 59/120 (49%), Gaps = 13/120 (10%)
Query: 2980 GHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGISAITISDVSGTI 3039
GH +TC+ + + LVSG +DC +WD+D + H++ I A I+D + +
Sbjct: 493 GHQGTITCM--DLCKNRLVSGGRDCQVKVWDVD-TGKCLKTFRHKDPILATRIND-TYIV 548
Query: 3040 VSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIIITGSQDGMVRVW 3099
SC + +W++ L + T G EGA+ C + W +++GS DG+V W
Sbjct: 549 SSCERGLVKVWHIAMAQL--VKTLSGHEGAVKCLFFDQ---WH----LLSGSTDGLVMAW 599
>gi|157694487 CMT1A duplicated region transcript 1 [Homo sapiens]
Length = 752
Score = 49.3 bits (116), Expect = 6e-05
Identities = 35/120 (29%), Positives = 59/120 (49%), Gaps = 13/120 (10%)
Query: 2980 GHTQAVTCLAASVTFSLLVSGSQDCTCILWDLDHLTHVTRLPAHREGISAITISDVSGTI 3039
GH +TC+ + + LVSG +DC +WD+D + H++ I A I+D + +
Sbjct: 493 GHQGTITCM--DLCKNRLVSGGRDCQVKVWDVD-TGKCLKTFRHKDPILATRIND-TYIV 548
Query: 3040 VSCAGAHLSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDTSQIIITGSQDGMVRVW 3099
SC + +W++ L + T G EGA+ C + W +++GS DG+V W
Sbjct: 549 SSCERGLVKVWHIAMAQL--VKTLSGHEGAVKCLFFDQ---WH----LLSGSTDGLVMAW 599
>gi|4758032 coatomer protein complex, subunit beta 2 (beta prime)
[Homo sapiens]
Length = 906
Score = 48.9 bits (115), Expect = 8e-05
Identities = 50/211 (23%), Positives = 85/211 (40%), Gaps = 34/211 (16%)
Query: 2908 GFDDFSCCLGSYGSDKVLMTFENLAAWGRCLCAVCPSPTTIVTSGTSTVVCVWELSMTKG 2967
G DD + +Y + + + FE + + RC+ AV P+ I+TS ++ +W+
Sbjct: 75 GADDMQIRVFNYNTLERVHMFEAHSDYIRCI-AVHPTQPFILTSSDDMLIKLWDWD---- 129
Query: 2968 RPRGLRLRQALYGHTQAVTCLAASVTFS-LLVSGSQDCTCILWDLDHLTHVTRLPAHREG 3026
+ Q GHT V + + + S S D T +W L + L H +G
Sbjct: 130 --KKWSCSQVFEGHTHYVMQIVINPKDNNQFASASLDRTIKVWQLGSSSPNFTLEGHEKG 187
Query: 3027 ISAITISDVSGTIVSCAGAH---LSLWNVNGQPLASITTAWGPEGAITCCCLMEGPAWDT 3083
++ I +GA + +W+ + TC +EG A +
Sbjct: 188 VNCIDYYSGGDKPYLISGADDRLVKIWDYQNK---------------TCVQTLEGHAQNV 232
Query: 3084 S--------QIIITGSQDGMVRVWKTEDVKM 3106
S IIITGS+DG VR+W + ++
Sbjct: 233 SCASFHPELPIIITGSEDGTVRIWHSSTYRL 263
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.135 0.408
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 125,299,621
Number of Sequences: 37866
Number of extensions: 5896494
Number of successful extensions: 18099
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 71
Number of HSP's successfully gapped in prelim test: 103
Number of HSP's that attempted gapping in prelim test: 17190
Number of HSP's gapped (non-prelim): 772
length of query: 3184
length of database: 18,247,518
effective HSP length: 121
effective length of query: 3063
effective length of database: 13,665,732
effective search space: 41858137116
effective search space used: 41858137116
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 72 (32.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.