Search of human proteins with 19071574

Search of human proteins with 19071574

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|19071574 potassium voltage-gated channel, subfamily G,
member 3 isoform 1 [Homo sapiens]
         (436 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|19071574 potassium voltage-gated channel, subfamily G, member...   881   0.0  
gi|27436993 potassium voltage-gated channel, subfamily G, member...   849   0.0  
gi|6912444 potassium voltage-gated channel, subfamily G, member ...   333   2e-91
gi|27436996 potassium voltage-gated channel, subfamily G, member...   332   4e-91
gi|27436988 potassium voltage-gated channel, subfamily G, member...   326   3e-89
gi|27436974 potassium voltage-gated channel, Shab-related subfam...   302   4e-82
gi|4826784 potassium voltage-gated channel, Shab-related subfami...   296   2e-80
gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens]    266   4e-71
gi|13492973 potassium voltage-gated channel delayed-rectifier pr...   256   2e-68
gi|25952108 potassium voltage-gated channel delayed-rectifier pr...   256   3e-68
gi|45383011 potassium voltage-gated channel, delayed-rectifier, ...   255   5e-68
gi|20070166 potassium voltage-gated channel, subfamily F, member...   239   4e-63
gi|19424136 potassium channel, subfamily V, member 2 [Homo sapiens]   236   3e-62
gi|25952092 potassium voltage-gated channel, shaker-related subf...   224   9e-59
gi|119395748 potassium voltage-gated channel subfamily A member ...   224   2e-58
gi|4826786 Shaw-related voltage-gated potassium channel protein ...   217   1e-56
gi|163792201 Shaw-related voltage-gated potassium channel protei...   217   1e-56
gi|88758565 potassium voltage-gated channel, shaker-related subf...   214   9e-56
gi|24497460 Shaw-related voltage-gated potassium channel protein...   214   9e-56
gi|5031819 potassium voltage-gated channel, shaker-related subfa...   211   8e-55
gi|88758576 Shaw-related voltage-gated potassium channel protein...   210   2e-54
gi|24497462 Shaw-related voltage-gated potassium channel protein...   210   2e-54
gi|24497464 Shaw-related voltage-gated potassium channel protein...   210   2e-54
gi|27436981 potassium voltage-gated channel, Shal-related subfam...   209   3e-54
gi|9789987 potassium voltage-gated channel, Shal-related subfami...   209   5e-54
gi|4504817 potassium voltage-gated channel, shaker-related subfa...   207   1e-53
gi|4826782 potassium voltage-gated channel, shaker-related subfa...   207   2e-53
gi|21217561 Shaw-related voltage-gated potassium channel protein...   206   3e-53
gi|21217563 Shaw-related voltage-gated potassium channel protein...   206   3e-53
gi|24497458 Shaw-related voltage-gated potassium channel protein...   206   3e-53

>gi|19071574 potassium voltage-gated channel, subfamily G, member 3
           isoform 1 [Homo sapiens]
          Length = 436

 Score =  881 bits (2276), Expect = 0.0
 Identities = 436/436 (100%), Positives = 436/436 (100%)

Query: 1   MTFGRSGAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNE 60
           MTFGRSGAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNE
Sbjct: 1   MTFGRSGAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNE 60

Query: 61  YFFDRHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRM 120
           YFFDRHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRM
Sbjct: 61  YFFDRHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRM 120

Query: 121 SDTYTFYSADEPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVF 180
           SDTYTFYSADEPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVF
Sbjct: 121 SDTYTFYSADEPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVF 180

Query: 181 VIVSMVVLCASTLPDWRNAAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIVRF 240
           VIVSMVVLCASTLPDWRNAAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIVRF
Sbjct: 181 VIVSMVVLCASTLPDWRNAAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIVRF 240

Query: 241 IVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVI 300
           IVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVI
Sbjct: 241 IVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVI 300

Query: 301 KLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSI 360
           KLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSI
Sbjct: 301 KLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSI 360

Query: 361 PAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHELK 420
           PAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHELK
Sbjct: 361 PAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHELK 420

Query: 421 FRSARYSRSLSTEFLN 436
           FRSARYSRSLSTEFLN
Sbjct: 421 FRSARYSRSLSTEFLN 436


>gi|27436993 potassium voltage-gated channel, subfamily G, member 3
           isoform 2 [Homo sapiens]
          Length = 425

 Score =  849 bits (2193), Expect = 0.0
 Identities = 425/436 (97%), Positives = 425/436 (97%), Gaps = 11/436 (2%)

Query: 1   MTFGRSGAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNE 60
           MTFGRSGAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNE
Sbjct: 1   MTFGRSGAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNE 60

Query: 61  YFFDRHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRM 120
           YFFDRHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRM
Sbjct: 61  YFFDRHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRM 120

Query: 121 SDTYTFYSADEPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVF 180
           SDTYTFYSADEPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVF
Sbjct: 121 SDTYTFYSADEPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVF 180

Query: 181 VIVSMVVLCASTLPDWRNAAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIVRF 240
           VIVSMVVLCASTLPDWRNAAADNRSLDDRSR           IIEAICIGWFTAECIVRF
Sbjct: 181 VIVSMVVLCASTLPDWRNAAADNRSLDDRSR-----------IIEAICIGWFTAECIVRF 229

Query: 241 IVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVI 300
           IVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVI
Sbjct: 230 IVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVI 289

Query: 301 KLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSI 360
           KLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSI
Sbjct: 290 KLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSI 349

Query: 361 PAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHELK 420
           PAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHELK
Sbjct: 350 PAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHELK 409

Query: 421 FRSARYSRSLSTEFLN 436
           FRSARYSRSLSTEFLN
Sbjct: 410 FRSARYSRSLSTEFLN 425


>gi|6912444 potassium voltage-gated channel, subfamily G, member 2
           [Homo sapiens]
          Length = 466

 Score =  333 bits (853), Expect = 2e-91
 Identities = 180/433 (41%), Positives = 264/433 (60%), Gaps = 34/433 (7%)

Query: 4   GRSGAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFF 63
           G + A  V++NVGG R  L+   L   PL R+ RL  CR   D+L VCDDYD  R+E+FF
Sbjct: 12  GGTRARHVIINVGGCRVRLAWAALARCPLARLERLRACRGHDDLLRVCDDYDVSRDEFFF 71

Query: 64  DRHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDT 123
           DR   AF  I+  +R  GKLR     C L+F +E+ YWG++ A LE CC RRL  R    
Sbjct: 72  DRSPCAFRAIVALLRA-GKLRLLRGPCALAFRDELAYWGIDEARLERCCLRRLRRR---- 126

Query: 124 YTFYSADEPGVLGRDEARPGGAEAAPSR---------RWLERMRRTFEEPTSSLAAQILA 174
                 +E     R      GA+ +P+R         R   R+R   + P S LA ++ A
Sbjct: 127 ------EEEAAEARAGPTERGAQGSPARALGPRGRLQRGRRRLRDVVDNPHSGLAGKLFA 180

Query: 175 SVSVVFVIVSMVVLCASTLPDWRNAAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTA 234
            VSV FV V+ V LC ST+PD R          +  R    P      ++E +C+ WF+ 
Sbjct: 181 CVSVSFVAVTAVGLCLSTMPDIRA---------EEERGECSPKCRSLFVLETVCVAWFSF 231

Query: 235 ECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQ--LQRAGVTLRVLR 292
           E ++R + +++KC F++ PLNIID+LA+ P+Y+S+L+ +  G      L+RAG+ LR+LR
Sbjct: 232 EFLLRSLQAESKCAFLRAPLNIIDILALLPFYVSLLLGLAAGPGGTKLLERAGLVLRLLR 291

Query: 293 MMRIFWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLET 352
            +R+ +V++LARH +GL++LGLT++RC RE  +LL+F+CVAMA+F+ L  L E  L    
Sbjct: 292 ALRVLYVMRLARHSLGLRSLGLTMRRCAREFGLLLLFLCVAMALFAPLVHLAERELG--- 348

Query: 353 SNKDFTSIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSF 412
           + +DF+S+PA+ WW +ISMTTVGYGDM P ++PG+++    ++SGI+L+A P+T I+H+F
Sbjct: 349 ARRDFSSVPASYWWAVISMTTVGYGDMVPRSLPGQVVALSSILSGILLMAFPVTSIFHTF 408

Query: 413 VQCYHELKFRSAR 425
            + Y ELK +  R
Sbjct: 409 SRSYSELKEQQQR 421


>gi|27436996 potassium voltage-gated channel, subfamily G, member 4
           [Homo sapiens]
          Length = 519

 Score =  332 bits (851), Expect = 4e-91
 Identities = 184/424 (43%), Positives = 262/424 (61%), Gaps = 33/424 (7%)

Query: 11  VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAF 70
           +++NVGG RY L    L  FPL R+S+L  CRS  +++++CDDYD +  E+FFDR   AF
Sbjct: 61  ILINVGGRRYLLPWSTLDRFPLSRLSKLRLCRSYEEIVQLCDDYDEDSQEFFFDRSPSAF 120

Query: 71  GFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTYTFYSAD 130
           G I+ ++   GKL     MC LSF  E+ YWG+E AHLE CC R+L  ++ +        
Sbjct: 121 GVIVSFLAA-GKLVLLQEMCALSFQEELAYWGIEEAHLERCCLRKLLRKLEELEELAKLH 179

Query: 131 EPGVLG--RDEARPGGAEAAPSRRW---LERMRRTFEEPTSSLAAQILASVSVVFVIVSM 185
              VL   R+  RP    A+ S RW   + R+R   E P S L  ++ A +S++FV  + 
Sbjct: 180 REDVLRQQRETRRP----ASHSSRWGLCMNRLREMVENPQSGLPGKVFACLSILFVATTA 235

Query: 186 VVLCASTLPDWRNAAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIVRFIVSKN 245
           V LC ST+PD R A  D      +  Y          I+E IC+ WF+ E  +RF+ +++
Sbjct: 236 VSLCVSTMPDLR-AEEDQGECSRKCYYIF--------IVETICVAWFSLEFCLRFVQAQD 286

Query: 246 KCEFVKRPLNIIDLLAITPYYISVLMTVFTGEN-------SQLQRAGVTLRVLRMMRIFW 298
           KC+F + PLNIID+LAI+PYY+S+ ++    E+       S L++ G+ LRVLR +RI +
Sbjct: 287 KCQFFQGPLNIIDILAISPYYVSLAVSEEPPEDGERPSGSSYLEKVGLVLRVLRALRILY 346

Query: 299 VIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEH--GLDLETSNKD 356
           V++LARH +GLQTLGLT++RC RE  +LL+F+ VA+ +FS L  + E   G  LE     
Sbjct: 347 VMRLARHSLGLQTLGLTVRRCTREFGLLLLFLAVAITLFSPLVYVAEKESGRVLE----- 401

Query: 357 FTSIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCY 416
           FTSIPA+ WW IISMTTVGYGDM P +VPG+++    ++SGI+++A P T I+H+F   Y
Sbjct: 402 FTSIPASYWWAIISMTTVGYGDMVPRSVPGQMVALSSILSGILIMAFPATSIFHTFSHSY 461

Query: 417 HELK 420
            ELK
Sbjct: 462 LELK 465


>gi|27436988 potassium voltage-gated channel, subfamily G, member 1
           [Homo sapiens]
          Length = 513

 Score =  326 bits (835), Expect = 3e-89
 Identities = 176/426 (41%), Positives = 258/426 (60%), Gaps = 25/426 (5%)

Query: 11  VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAF 70
           +++NVGG +YSL    L +FPL R+ +L  C +  D+L VCDDYD   NE+FFDR+  AF
Sbjct: 65  IIINVGGIKYSLPWTTLDEFPLTRLGQLKACTNFDDILNVCDDYDVTCNEFFFDRNPGAF 124

Query: 71  GFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTYTFYSAD 130
           G IL ++R  GKLR    MC LSF  E++YWG+   HL+ CC+RR   ++ +       +
Sbjct: 125 GTILTFLRA-GKLRLLREMCALSFQEELLYWGIAEDHLDGCCKRRYLQKIEEFAEMVERE 183

Query: 131 EPGVL----GRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMV 186
           E        GRD   P   E    R  + R+R   E P S L  ++ A +SV+FV V+ V
Sbjct: 184 EEDDALDSEGRDSEGPAEGEGRLGR-CMRRLRDMVERPHSGLPGKVFACLSVLFVTVTAV 242

Query: 187 VLCASTLPDWRNAAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIVRFIVSKNK 246
            L  STLP  R         ++  +           I+E++C+GWF+ E ++R I + +K
Sbjct: 243 NLSVSTLPSLR---------EEEEQGHCSQMCHNVFIVESVCVGWFSLEFLLRLIQAPSK 293

Query: 247 CEFVKRPLNIIDLLAITPYYISVLMTVFTGE-------NSQLQRAGVTLRVLRMMRIFWV 299
             F++ PL +IDL+AI PYYI++L+             NS L + G+ LRVLR +RI +V
Sbjct: 294 FAFLRSPLTLIDLVAILPYYITLLVDGAAAGRRKPGAGNSYLDKVGLVLRVLRALRILYV 353

Query: 300 IKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTS 359
           ++LARH +GLQTLGLT +RC RE  +LL+F+CVA+A+F+ L  ++E+ +     + +FTS
Sbjct: 354 MRLARHSLGLQTLGLTARRCTREFGLLLLFLCVAIALFAPLLYVIENEM---ADSPEFTS 410

Query: 360 IPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHEL 419
           IPA  WW +I+MTTVGYGDM P + PG+++    ++SGI+L+A P+T I+H+F + Y EL
Sbjct: 411 IPACYWWAVITMTTVGYGDMVPRSTPGQVVALSSILSGILLMAFPVTSIFHTFSRSYLEL 470

Query: 420 KFRSAR 425
           K    R
Sbjct: 471 KQEQER 476


>gi|27436974 potassium voltage-gated channel, Shab-related
           subfamily, member 2 [Homo sapiens]
          Length = 911

 Score =  302 bits (773), Expect = 4e-82
 Identities = 165/423 (39%), Positives = 244/423 (57%), Gaps = 18/423 (4%)

Query: 11  VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAF 70
           V +NVGG  + +    L   P  R+ +L  C +   +LEVCDDY+   NEYFFDRH  AF
Sbjct: 37  VKINVGGLNHEVLWRTLDRLPRTRLGKLRDCNTHESLLEVCDDYNLNENEYFFDRHPGAF 96

Query: 71  GFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTYTFYSAD 130
             IL + R  GKL     MC LSF  E+ YWG++  +LE CCQ R   +  +        
Sbjct: 97  TSILNFYRT-GKLHMMEEMCALSFGQELDYWGIDEIYLESCCQARYHQK-KEQMNEELRR 154

Query: 131 EPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCA 190
           E   +   E         P +R  +++    E+P SS+AA+ILA VS++F+++S + L  
Sbjct: 155 EAETMREREGEEFDNTCCPDKR--KKLWDLLEKPNSSVAAKILAIVSILFIVLSTIALSL 212

Query: 191 STLPDWRNAAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIVRFIVSKNKCEFV 250
           +TLP+ +      +  D+R              +EA+CI WFT E ++RF+ S NK +F 
Sbjct: 213 NTLPELQETDEFGQLNDNRQLAH----------VEAVCIAWFTMEYLLRFLSSPNKWKFF 262

Query: 251 KRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVIKLARHFIGLQ 310
           K PLN+IDLLAI PYY+++ +T       Q Q     +++ R+MRI  ++KLARH  GLQ
Sbjct: 263 KGPLNVIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILRILKLARHSTGLQ 322

Query: 311 TLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSIPAACWWVIIS 370
           +LG TL+R Y E+ +L++F+ + + IFS+L    E   D       FTSIPA+ WW  I+
Sbjct: 323 SLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDEDA----TKFTSIPASFWWATIT 378

Query: 371 MTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHELKFRSARYSRSL 430
           MTTVGYGD+YP T+ G+I+GG+C ++G++++ALPI  I ++F + Y E K +     R  
Sbjct: 379 MTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKEQKRQEKAIKRRE 438

Query: 431 STE 433
           + E
Sbjct: 439 ALE 441


>gi|4826784 potassium voltage-gated channel, Shab-related subfamily,
           member 1 [Homo sapiens]
          Length = 858

 Score =  296 bits (759), Expect = 2e-80
 Identities = 169/435 (38%), Positives = 249/435 (57%), Gaps = 20/435 (4%)

Query: 1   MTFGRSGAAS--VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRER 58
           M   RS A S  V LNVGG  + +    L   P  R+ +L  C +   +LEVCDDY  + 
Sbjct: 21  MEIVRSKACSRRVRLNVGGLAHEVLWRTLDRLPRTRLGKLRDCNTHDSLLEVCDDYSLDD 80

Query: 59  NEYFFDRHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDD 118
           NEYFFDRH  AF  IL + R  G+L     MC LSF  E+ YWG++  +LE CCQ R   
Sbjct: 81  NEYFFDRHPGAFTSILNFYRT-GRLHMMEEMCALSFSQELDYWGIDEIYLESCCQARYHQ 139

Query: 119 RMSDTYTFYSADEPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSV 178
           +          +   +  R+         A  R+ L  +    E+P SS+AA+ILA +S+
Sbjct: 140 KKEQMNEELKREAETLREREGEEFDNTCCAEKRKKLWDL---LEKPNSSVAAKILAIISI 196

Query: 179 VFVIVSMVVLCASTLPDWRNAAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIV 238
           +F+++S + L  +TLP+ +       SLD+  + +  P       +EA+CI WFT E ++
Sbjct: 197 MFIVLSTIALSLNTLPELQ-------SLDEFGQSTDNP---QLAHVEAVCIAWFTMEYLL 246

Query: 239 RFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFW 298
           RF+ S  K +F K PLN IDLLAI PYY+++ +T       Q Q     +++ R+MRI  
Sbjct: 247 RFLSSPKKWKFFKGPLNAIDLLAILPYYVTIFLTESNKSVLQFQNVRRVVQIFRIMRILR 306

Query: 299 VIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFT 358
           ++KLARH  GLQ+LG TL+R Y E+ +L++F+ + + IFS+L    E   D    +  F 
Sbjct: 307 ILKLARHSTGLQSLGFTLRRSYNELGLLILFLAMGIMIFSSLVFFAEKDED----DTKFK 362

Query: 359 SIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHE 418
           SIPA+ WW  I+MTTVGYGD+YP T+ G+I+GG+C ++G++++ALPI  I ++F + Y E
Sbjct: 363 SIPASFWWATITMTTVGYGDIYPKTLLGKIVGGLCCIAGVLVIALPIPIIVNNFSEFYKE 422

Query: 419 LKFRSARYSRSLSTE 433
            K +     R  + E
Sbjct: 423 QKRQEKAIKRREALE 437


>gi|7657289 potassium channel, subfamily V, member 1 [Homo sapiens]
          Length = 500

 Score =  266 bits (679), Expect = 4e-71
 Identities = 153/427 (35%), Positives = 243/427 (56%), Gaps = 41/427 (9%)

Query: 13  LNVGGARYSLSRELLKDFPLRRVSRLH----------GCRSERDVLEVCDDYDRERNEYF 62
           +NVGG+R+ LS++ L  FP  R+ +L              +    LE+CDD +   NEYF
Sbjct: 43  VNVGGSRFVLSQQALSCFPHTRLGKLAVVVASYRRPGALAAVPSPLELCDDANPVDNEYF 102

Query: 63  FDRHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDR--M 120
           FDR S+AF ++L Y R  G+L    ++C LSF  E+ YWG++   ++ CC+ R   R  +
Sbjct: 103 FDRSSQAFRYVLHYYRT-GRLHVMEQLCALSFLQEIQYWGIDELSIDSCCRDRYFRRKEL 161

Query: 121 SDTYTFYSADEPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVF 180
           S+T  F    E      +  +       P+ R  +++    E+P SS AA+I   +S++F
Sbjct: 162 SETLDFKKDTEDQESQHESEQDFSQGPCPTVR--QKLWNILEKPGSSTAARIFGVISIIF 219

Query: 181 VIVSMVVLCASTLP-DWRNAAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIVR 239
           V+VS++ +   +    W     D + L+               I+E +CI WFT E ++R
Sbjct: 220 VVVSIINMALMSAELSW----LDLQLLE---------------ILEYVCISWFTGEFVLR 260

Query: 240 FIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENS--QLQRAGVTLRVLRMMRIF 297
           F+  +++C F+++  NIIDLLAI P+YI++L+   +G  +  +L+  G  ++VLR++R  
Sbjct: 261 FLCVRDRCRFLRKVPNIIDLLAILPFYITLLVESLSGSQTTQELENVGRIVQVLRLLRAL 320

Query: 298 WVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDF 357
            ++KL RH  GL++LG+T+ +CY E+ +LL+F+ V ++IFS +    E  +   T    F
Sbjct: 321 RMLKLGRHSTGLRSLGMTITQCYEEVGLLLLFLSVGISIFSTVEYFAEQSIPDTT----F 376

Query: 358 TSIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYH 417
           TS+P A WW   SMTTVGYGD+ P T  G+I+  +C++SGI++LALPI  I   F  CY 
Sbjct: 377 TSVPCAWWWATTSMTTVGYGDIRPDTTTGKIVAFMCILSGILVLALPIAIINDRFSACYF 436

Query: 418 ELKFRSA 424
            LK + A
Sbjct: 437 TLKLKEA 443


>gi|13492973 potassium voltage-gated channel delayed-rectifier
           protein S1 [Homo sapiens]
          Length = 526

 Score =  256 bits (655), Expect = 2e-68
 Identities = 160/446 (35%), Positives = 235/446 (52%), Gaps = 41/446 (9%)

Query: 13  LNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAFGF 72
           +NVGG R  LS   L  FP  R+ RL    SE     +CDDYD    E++FDRH   F  
Sbjct: 54  VNVGGVRRQLSARALARFPGTRLGRLQAAASEEQARRLCDDYDEAAREFYFDRHPGFFLS 113

Query: 73  ILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCC-----QRRLD-----DRMSD 122
           +L + R  G L     +C  +F  E  YWGL    L  CC     +RRL      D  SD
Sbjct: 114 LLHFYRT-GHLHVLDELCVFAFGQEADYWGLGENALAACCRARYLERRLTQPHAWDEDSD 172

Query: 123 TYTFYSA--DEPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVF 180
           T +      DE   + R+ AR G A     RR   R+  T E P  SL +++ + VS+  
Sbjct: 173 TPSSVDPCPDEISDVQRELARYGAARCGRLRR---RLWLTMENPGYSLPSKLFSCVSISV 229

Query: 181 VIVSMVVLCASTLPDW--RNAAADNRSLDDRSRYSAGPGREPSGI--------IEAICIG 230
           V+ S+  +C  +LP++  R AAA        +  +   GR P G+        +E  CI 
Sbjct: 230 VLASIAAMCIHSLPEYQAREAAA--------AVAAVAAGRSPEGVRDDPVLRRLEYFCIA 281

Query: 231 WFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENS--QLQRAGVTL 288
           WF+ E   R +++ +   F   PLN+ID++++ P+Y+++L  V  G+    +    G  +
Sbjct: 282 WFSFEVSSRLLLAPSTRNFFCHPLNLIDIVSVLPFYLTLLAGVALGDQGGKEFGHLGKVV 341

Query: 289 RVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGL 348
           +V R+MRIF V+KLARH  GL++LG TLK  YRE+ +LL+++ V +++FS ++   E   
Sbjct: 342 QVFRLMRIFRVLKLARHSTGLRSLGATLKHSYREVGILLLYLAVGVSVFSGVAYTAEKEE 401

Query: 349 DLETSNKDFTSIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFI 408
           D+      F +IPA  WW  +SMTTVGYGD+ P+TV G++    C++ GI+++ALPIT I
Sbjct: 402 DV-----GFNTIPACWWWGTVSMTTVGYGDVVPVTVAGKLAASGCILGGILVVALPITII 456

Query: 409 YHSFVQCYHELKFRSARYSRSLSTEF 434
           ++ F   Y   K   A    S   EF
Sbjct: 457 FNKFSHFYRRQKALEAAVRNSNHQEF 482


>gi|25952108 potassium voltage-gated channel delayed-rectifier
           protein S3 [Homo sapiens]
          Length = 491

 Score =  256 bits (654), Expect = 3e-68
 Identities = 142/424 (33%), Positives = 234/424 (55%), Gaps = 37/424 (8%)

Query: 11  VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAF 70
           V LNVGG + S+ +  L  FP  R+ +L  C SE  +LE+CDDY     EY+FDR+   F
Sbjct: 17  VNLNVGGFKQSVDQSTLLRFPHTRLGKLLTCHSEEAILELCDDYSVADKEYYFDRNPSLF 76

Query: 71  GFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTY------ 124
            ++L +    GKL     +C  SF  E+ YWG+    ++ CC  R  +R  + +      
Sbjct: 77  RYVLNFYYT-GKLHVMEELCVFSFCQEIEYWGINELFIDSCCSNRYQERKEENHEKDWDQ 135

Query: 125 ------TFYSADEPGVLGRDEARPGGAEAAPSRR--WLERMRRTFEEPTSSLAAQILASV 176
                 T  S +E  +  ++  +         R+  W+       E P   L+A+++A  
Sbjct: 136 KSHDVSTDSSFEESSLFEKELEKFDTLRFGQLRKKIWIR-----MENPAYCLSAKLIAIS 190

Query: 177 SVVFVIVSMVVLCASTLPDWRNAAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAEC 236
           S+  V+ S+V +C  ++ +++N   ++  +DD       P  E    +E  CI WFT E 
Sbjct: 191 SLSVVLASIVAMCVHSMSEFQN---EDGEVDD-------PVLEG---VEIACIAWFTGEL 237

Query: 237 IVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRI 296
            VR   +  + +F K PLNIID ++I P+Y ++ +     E+  ++  G  +++LR+MRI
Sbjct: 238 AVRLAAAPCQKKFWKNPLNIIDFVSIIPFYATLAVDTKEEESEDIENMGKVVQILRLMRI 297

Query: 297 FWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKD 356
           F ++KLARH +GL++LG TL+  Y E+ +LL+F+ V ++IFS    +L + ++ +     
Sbjct: 298 FRILKLARHSVGLRSLGATLRHSYHEVGLLLLFLSVGISIFS----VLIYSVEKDDHTSS 353

Query: 357 FTSIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCY 416
            TSIP   WW  ISMTTVGYGD +P+T+ G+++   C++ GI+++ALPIT I++ F + Y
Sbjct: 354 LTSIPICWWWATISMTTVGYGDTHPVTLAGKLIASTCIICGILVVALPITIIFNKFSKYY 413

Query: 417 HELK 420
            + K
Sbjct: 414 QKQK 417


>gi|45383011 potassium voltage-gated channel, delayed-rectifier,
           subfamily S, member 2 [Homo sapiens]
          Length = 477

 Score =  255 bits (652), Expect = 5e-68
 Identities = 143/423 (33%), Positives = 230/423 (54%), Gaps = 37/423 (8%)

Query: 13  LNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAFGF 72
           +NVGG +  L    L  FP  R+ RL  C S   +LE+CDDYD  + E++FDR+ E F +
Sbjct: 21  INVGGFKRRLRSHTLLRFPETRLGRLLLCHSREAILELCDDYDDVQREFYFDRNPELFPY 80

Query: 73  ILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCC------------QRRLDDRM 120
           +L +    GKL     +C  SF  E+ YWG+    ++ CC            Q + D++ 
Sbjct: 81  VLHFYHT-GKLHVMAELCVFSFSQEIEYWGINEFFIDSCCSYSYHGRKVEPEQEKWDEQS 139

Query: 121 SDTYTFYSADEPGVLGRDEARPGGAEAAPSRR--WLERMRRTFEEPTSSLAAQILASVSV 178
               T  S DE      D ++  G      RR  WL       + P  S+ +++ + +S+
Sbjct: 140 DQESTTSSFDEILAFYNDASKFDGQPLGNFRRQLWL-----ALDNPGYSVLSRVFSILSI 194

Query: 179 VFVIVSMVVLCASTLPDWRNAAADNRSLDDRSRYSAGPGREPS-GIIEAICIGWFTAECI 237
           + V+ S++ +C ++LPD++   +              PG +P   I+E   I WFT E +
Sbjct: 195 LVVMGSIITMCLNSLPDFQIPDSQGN-----------PGEDPRFEIVEHFGIAWFTFELV 243

Query: 238 VRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIF 297
            RF V+ +  +F K  LN+IDL++I P+YI++++ +       L   G   +VLR+MRIF
Sbjct: 244 ARFAVAPDFLKFFKNALNLIDLMSIVPFYITLVVNLVVESTPTLANLGRVAQVLRLMRIF 303

Query: 298 WVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDF 357
            ++KLARH  GL++LG TLK  Y+E+ +LL+++ V ++IFS ++  +E     +  N+  
Sbjct: 304 RILKLARHSTGLRSLGATLKYSYKEVGLLLLYLSVGISIFSVVAYTIE-----KEENEGL 358

Query: 358 TSIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYH 417
            +IPA  WW  +SMTTVGYGD+ P T  G++    C+++GI+++ LPIT I++ F   Y 
Sbjct: 359 ATIPACWWWATVSMTTVGYGDVVPGTTAGKLTASACILAGILVVVLPITLIFNKFSHFYR 418

Query: 418 ELK 420
             K
Sbjct: 419 RQK 421


>gi|20070166 potassium voltage-gated channel, subfamily F, member 1
           [Homo sapiens]
          Length = 494

 Score =  239 bits (610), Expect = 4e-63
 Identities = 146/440 (33%), Positives = 239/440 (54%), Gaps = 29/440 (6%)

Query: 5   RSGAAS----VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSER--DVLEVCDDYDRER 58
           +S AAS    +V+NVGG R  L  +LL  +P  R++ L  C +     +  +CDDYD  +
Sbjct: 15  QSSAASDDIEIVVNVGGVRQVLYGDLLSQYPETRLAELINCLAGGYDTIFSLCDDYDPGK 74

Query: 59  NEYFFDRHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDD 118
            E++FDR  +AF  ++  V   G++     +C + F NEM +W ++   L+ CC+  L +
Sbjct: 75  REFYFDRDPDAFKCVI-EVYYFGEVHMKKGICPICFKNEMDFWKVDLKFLDDCCKSHLSE 133

Query: 119 RMSDTYTFYSADEPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSV 178
           +  +        +   L  D+     AE    RR  + + +  E+P SS  A+++A +S 
Sbjct: 134 KREELEEIARRVQ---LILDDLGVDAAEGR-WRRCQKCVWKFLEKPESSCPARVVAVLSF 189

Query: 179 VFVIVSMVVLCASTLPDWRNAAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIV 238
           + ++VS VV+C  T+P+ +   A+   ++  +  +          +E  CIGWFT E ++
Sbjct: 190 LLILVSSVVMCMGTIPELQVLDAEGNRVEHPTLEN----------VETACIGWFTLEYLL 239

Query: 239 RFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFW 298
           R   S NK  F    +NI+D+LAI P+Y+S+ +T       +L      ++ LR+MRI  
Sbjct: 240 RLFSSPNKLHFALSFMNIVDVLAILPFYVSLTLTHLGARMMELTNVQQAVQALRIMRIAR 299

Query: 299 VIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKD-- 356
           + KLARH  GLQTL   LKR ++E+ +LL+++ V + +FSAL      G  +E S+ +  
Sbjct: 300 IFKLARHSSGLQTLTYALKRSFKELGLLLMYLAVGIFVFSAL------GYTMEQSHPETL 353

Query: 357 FTSIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCY 416
           F SIP + WW II+MTTVGYGD+YP T  G++   +  + G++ +ALPI  I ++FV+ Y
Sbjct: 354 FKSIPQSFWWAIITMTTVGYGDIYPKTTLGKLNAAISFLCGVIAIALPIHPIINNFVRYY 413

Query: 417 HELKFRSARYSRSLSTEFLN 436
           ++ +         L    LN
Sbjct: 414 NKQRVLETAAKHELELMELN 433


>gi|19424136 potassium channel, subfamily V, member 2 [Homo sapiens]
          Length = 545

 Score =  236 bits (602), Expect = 3e-62
 Identities = 149/426 (34%), Positives = 226/426 (53%), Gaps = 40/426 (9%)

Query: 13  LNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAFGF 72
           +NVGG  Y L    L  FP  R+ RL    S    L +CDDY+ + +EYFFDR    F  
Sbjct: 101 VNVGGHSYQLDYCELAGFPKTRLGRLATSTSRSRQLSLCDDYEEQTDEYFFDRDPAVFQL 160

Query: 73  ILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCC-----QRR--LDDRMSDTYT 125
           +  +    G L     +C   F  E+ YWG+   +   CC     +RR  L +R+   + 
Sbjct: 161 VYNFYLS-GVLLVLDGLCPRRFLEELGYWGVRLKYTPRCCRICFEERRDELSERLKIQHE 219

Query: 126 FYS---ADEPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVI 182
             +    +E   L RD    G     P RR   R+    E+P SS+AA+ +   S  FV+
Sbjct: 220 LRAQAQVEEAEELFRDMRFYG-----PQRR---RLWNLMEKPFSSVAAKAIGVASSTFVL 271

Query: 183 VSMVVLCASTLPDWRNAAADNRSLDDRSRYSAGPGREPS-GIIEAICIGWFTAECIVRFI 241
           VS+V L  +T+ + +  +              GP   P    +E +C+G+FT E ++R  
Sbjct: 272 VSVVALALNTVEEMQQHSGQGEG---------GPDLRPILEHVEMLCMGFFTLEYLLRLA 322

Query: 242 VSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQ-------LQRAGVTLRVLRMM 294
            + +   F +  LN++DL+AI P Y+ +L+  FTGE  Q       + + G  LRV+R+M
Sbjct: 323 STPDLRRFARSALNLVDLVAILPLYLQLLLECFTGEGHQRGQTVGSVGKVGQVLRVMRLM 382

Query: 295 RIFWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSN 354
           RIF ++KLARH  GL+  G TL++CY+++  LL+FI + +  FSA    +EH  D+ ++N
Sbjct: 383 RIFRILKLARHSTGLRAFGFTLRQCYQQVGCLLLFIAMGIFTFSAAVYSVEH--DVPSTN 440

Query: 355 KDFTSIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQ 414
             FT+IP + WW  +S++TVGYGDMYP T  GR    +C+  GI+L  +PI+ +Y+ F  
Sbjct: 441 --FTTIPHSWWWAAVSISTVGYGDMYPETHLGRFFAFLCIAFGIILNGMPISILYNKFSD 498

Query: 415 CYHELK 420
            Y +LK
Sbjct: 499 YYSKLK 504


>gi|25952092 potassium voltage-gated channel, shaker-related
           subfamily, member 7 [Homo sapiens]
          Length = 456

 Score =  224 bits (572), Expect = 9e-59
 Identities = 148/426 (34%), Positives = 222/426 (52%), Gaps = 57/426 (13%)

Query: 11  VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAF 70
           +VLNV G R+      L  FP      L G  + R        YD  R EYFFDRH  +F
Sbjct: 15  LVLNVAGLRFETRARTLGRFP----DTLLGDPARRGRF-----YDDARREYFFDRHRPSF 65

Query: 71  GFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTYTFYSAD 130
             +L Y +  G+LR    +    F  E+ ++GL  A L                      
Sbjct: 66  DAVLYYYQSGGRLRRPAHVPLDVFLEEVAFYGLGAAALAR-------------------- 105

Query: 131 EPGVLGRDEARPGGAEAA-PSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLC 189
               L  DE  P   E   P R +  ++   FE P SS AA++LA VSV+ ++VS+VV C
Sbjct: 106 ----LREDEGCPVPPERPLPRRAFARQLWLLFEFPESSQAARVLAVVSVLVILVSIVVFC 161

Query: 190 ASTLPDWRN---------AAADN---RSLDDRSRYSAGPGR----EPSGIIEAICIGWFT 233
             TLPD+R+         AAA       L+  S+    P R    +P  ++E +CI WF+
Sbjct: 162 LETLPDFRDDRDGTGLAAAAAAGPFPAPLNGSSQMPGNPPRLPFNDPFFVVETLCICWFS 221

Query: 234 AECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAG--VTLRVL 291
            E +VR +V  +K  F K  +N+ID +AI PY+++ L T    +    Q+A     LRV+
Sbjct: 222 FELLVRLLVCPSKAIFFKNVMNLIDFVAILPYFVA-LGTELARQRGVGQQAMSLAILRVI 280

Query: 292 RMMRIFWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLE 351
           R++R+F + KL+RH  GLQ LG TL+   RE+ +L+ F+ + + +FS+     E    ++
Sbjct: 281 RLVRVFRIFKLSRHSKGLQILGQTLRASMRELGLLIFFLFIGVVLFSSAVYFAE----VD 336

Query: 352 TSNKDFTSIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHS 411
             +  FTSIP + WW +++MTTVGYGDM P+TV G+I+G +C ++G++ ++LP+  I  +
Sbjct: 337 RVDSHFTSIPESFWWAVVTMTTVGYGDMAPVTVGGKIVGSLCAIAGVLTISLPVPVIVSN 396

Query: 412 FVQCYH 417
           F   YH
Sbjct: 397 FSYFYH 402


>gi|119395748 potassium voltage-gated channel subfamily A member 1
           [Homo sapiens]
          Length = 495

 Score =  224 bits (570), Expect = 2e-58
 Identities = 137/414 (33%), Positives = 223/414 (53%), Gaps = 43/414 (10%)

Query: 11  VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAF 70
           VV+N+ G R+    + L  FP    + L G   +R        +D  RNEYFFDR+  +F
Sbjct: 39  VVINISGLRFETQLKTLAQFP----NTLLGNPKKR-----MRYFDPLRNEYFFDRNRPSF 89

Query: 71  GFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTYTFYSAD 130
             IL Y +  G+LR    +    F  E+ ++ L    +E                 +  D
Sbjct: 90  DAILYYYQSGGRLRRPVNVPLDMFSEEIKFYELGEEAMEK----------------FRED 133

Query: 131 EPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCA 190
           E  +  ++E RP      P + +  ++   FE P SS  A+++A VSV+ +++S+V+ C 
Sbjct: 134 EGFI--KEEERP-----LPEKEYQRQVWLLFEYPESSGPARVIAIVSVMVILISIVIFCL 186

Query: 191 STLPDWRN----AAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIVRFIVSKNK 246
            TLP+ ++        +R  +    Y++    +P  I+E +CI WF+ E +VRF    +K
Sbjct: 187 ETLPELKDDKDFTGTVHRIDNTTVIYNSNIFTDPFFIVETLCIIWFSFELVVRFFACPSK 246

Query: 247 CEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTL---RVLRMMRIFWVIKLA 303
            +F K  +N ID++AI PY+I++   +   E +Q      +L   RV+R++R+F + KL+
Sbjct: 247 TDFFKNIMNFIDIVAIIPYFITLGTEIAEQEGNQKGEQATSLAILRVIRLVRVFRIFKLS 306

Query: 304 RHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSIPAA 363
           RH  GLQ LG TLK   RE+ +L+ F+ + + +FS+     E     E +   F+SIP A
Sbjct: 307 RHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE----AEEAESHFSSIPDA 362

Query: 364 CWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYH 417
            WW ++SMTTVGYGDMYP+T+ G+I+G +C ++G++ +ALP+  I  +F   YH
Sbjct: 363 FWWAVVSMTTVGYGDMYPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYH 416


>gi|4826786 Shaw-related voltage-gated potassium channel protein 1
           isoform B [Homo sapiens]
          Length = 511

 Score =  217 bits (553), Expect = 1e-56
 Identities = 144/443 (32%), Positives = 221/443 (49%), Gaps = 46/443 (10%)

Query: 11  VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAF 70
           +V+NVGG R+   R  L+  P  R++ L    +E D     D YD   +E+FFDRH   F
Sbjct: 10  IVINVGGTRHQTYRSTLRTLPGTRLAWL----AEPDAHSHFD-YDPRADEFFFDRHPGVF 64

Query: 71  GFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCC-----QRRLDDRMSDTY- 124
             IL Y R  GKL     +C   +  E+ +WG++   +E CC     Q R  +   D++ 
Sbjct: 65  AHILNYYRT-GKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFG 123

Query: 125 --------TFYSADEPGVLGRDEAR------------PGGAEAAPSRRWLERMRRTFEEP 164
                       AD PG  G  E              P G      RRW  R+   FE+P
Sbjct: 124 GAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDP 183

Query: 165 TSSLAAQILASVSVVFVIVSMVVLCASTL----PDWRNAAADNRSLDDRSRYSAGPGREP 220
            SS  A+ +A  S+ F++VS+   C  T     P       +N     + RY      E 
Sbjct: 184 YSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEA 243

Query: 221 S-GIIEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENS 279
               IE +C+ WFT E ++R I   NK EF+K  LNIID +AI P+Y+ V ++   G +S
Sbjct: 244 FLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLS---GLSS 300

Query: 280 QLQRAGVT-LRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFS 338
           +  +  +  LRV+R +RI  + KL RHF+GL+ LG TL+    E ++L++F+ + + IF+
Sbjct: 301 KAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA 360

Query: 339 ALSQLLEH-----GLDLETSNKDFTSIPAACWWVIISMTTVGYGDMYPITVPGRILGGVC 393
            +    E           + +  F +IP   WW +++MTT+GYGDMYP T  G ++G +C
Sbjct: 361 TMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALC 420

Query: 394 VVSGIVLLALPITFIYHSFVQCY 416
            ++G++ +A+P+  I ++F   Y
Sbjct: 421 ALAGVLTIAMPVPVIVNNFGMYY 443


>gi|163792201 Shaw-related voltage-gated potassium channel protein 1
           isoform A [Homo sapiens]
          Length = 585

 Score =  217 bits (553), Expect = 1e-56
 Identities = 144/443 (32%), Positives = 221/443 (49%), Gaps = 46/443 (10%)

Query: 11  VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAF 70
           +V+NVGG R+   R  L+  P  R++ L    +E D     D YD   +E+FFDRH   F
Sbjct: 10  IVINVGGTRHQTYRSTLRTLPGTRLAWL----AEPDAHSHFD-YDPRADEFFFDRHPGVF 64

Query: 71  GFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCC-----QRRLDDRMSDTY- 124
             IL Y R  GKL     +C   +  E+ +WG++   +E CC     Q R  +   D++ 
Sbjct: 65  AHILNYYRT-GKLHCPADVCGPLYEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDSFG 123

Query: 125 --------TFYSADEPGVLGRDEAR------------PGGAEAAPSRRWLERMRRTFEEP 164
                       AD PG  G  E              P G      RRW  R+   FE+P
Sbjct: 124 GAPLDNSADDADADGPGDSGDGEDELEMTKRLALSDSPDGRPGGFWRRWQPRIWALFEDP 183

Query: 165 TSSLAAQILASVSVVFVIVSMVVLCASTL----PDWRNAAADNRSLDDRSRYSAGPGREP 220
            SS  A+ +A  S+ F++VS+   C  T     P       +N     + RY      E 
Sbjct: 184 YSSRYARYVAFASLFFILVSITTFCLETHERFNPIVNKTEIENVRNGTQVRYYREAETEA 243

Query: 221 S-GIIEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENS 279
               IE +C+ WFT E ++R I   NK EF+K  LNIID +AI P+Y+ V ++   G +S
Sbjct: 244 FLTYIEGVCVVWFTFEFLMRVIFCPNKVEFIKNSLNIIDFVAILPFYLEVGLS---GLSS 300

Query: 280 QLQRAGVT-LRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFS 338
           +  +  +  LRV+R +RI  + KL RHF+GL+ LG TL+    E ++L++F+ + + IF+
Sbjct: 301 KAAKDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFA 360

Query: 339 ALSQLLEH-----GLDLETSNKDFTSIPAACWWVIISMTTVGYGDMYPITVPGRILGGVC 393
            +    E           + +  F +IP   WW +++MTT+GYGDMYP T  G ++G +C
Sbjct: 361 TMIYYAERIGAQPNDPSASEHTHFKNIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALC 420

Query: 394 VVSGIVLLALPITFIYHSFVQCY 416
            ++G++ +A+P+  I ++F   Y
Sbjct: 421 ALAGVLTIAMPVPVIVNNFGMYY 443


>gi|88758565 potassium voltage-gated channel, shaker-related
           subfamily, member 3 [Homo sapiens]
          Length = 575

 Score =  214 bits (546), Expect = 9e-56
 Identities = 137/419 (32%), Positives = 224/419 (53%), Gaps = 48/419 (11%)

Query: 11  VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAF 70
           VV+N+ G R+    + L  FP      L G    R        +D  RNEYFFDR+  +F
Sbjct: 106 VVINISGLRFETQLKTLCQFP----ETLLGDPKRR-----MRYFDPLRNEYFFDRNRPSF 156

Query: 71  GFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTYTFYSAD 130
             IL Y +  G++R  P    +  ++E I +             +L +   + +     +
Sbjct: 157 DAILYYYQSGGRIR-RPVNVPIDIFSEEIRF------------YQLGEEAMEKFR----E 199

Query: 131 EPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCA 190
           + G L R+E RP      P R +  ++   FE P SS  A+ +A VSV+ +++S+V+ C 
Sbjct: 200 DEGFL-REEERP-----LPRRDFQRQVWLLFEYPESSGPARGIAIVSVLVILISIVIFCL 253

Query: 191 STLPDWRN-----AAADNRSLD------DRSRYSAGPGREPSGIIEAICIGWFTAECIVR 239
            TLP++R+     A+    S +        SR  A    +P  ++E +CI WF+ E +VR
Sbjct: 254 ETLPEFRDEKDYPASTSQDSFEAAGNSTSGSRAGASSFSDPFFVVETLCIIWFSFELLVR 313

Query: 240 FIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTGE-NSQLQRAGVTLRVLRMMRIFW 298
           F    +K  F +  +N+ID++AI PY+I++   +   + N Q   +   LRV+R++R+F 
Sbjct: 314 FFACPSKATFSRNIMNLIDIVAIIPYFITLGTELAERQGNGQQAMSLAILRVIRLVRVFR 373

Query: 299 VIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFT 358
           + KL+RH  GLQ LG TLK   RE+ +L+ F+ + + +FS+     E     +     F+
Sbjct: 374 IFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE----ADDPTSGFS 429

Query: 359 SIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYH 417
           SIP A WW +++MTTVGYGDM+P+T+ G+I+G +C ++G++ +ALP+  I  +F   YH
Sbjct: 430 SIPDAFWWAVVTMTTVGYGDMHPVTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYH 488


>gi|24497460 Shaw-related voltage-gated potassium channel protein 3
           [Homo sapiens]
          Length = 757

 Score =  214 bits (546), Expect = 9e-56
 Identities = 143/475 (30%), Positives = 232/475 (48%), Gaps = 73/475 (15%)

Query: 4   GRSGAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFF 63
           G   +  +V+NVGG R+   R  L+  P  R++ L    +         DYD   +E+FF
Sbjct: 83  GGGDSGKIVINVGGVRHETYRSTLRTLPGTRLAGLTEPEAAARF-----DYDPGADEFFF 137

Query: 64  DRHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCC---QRRLDDRM 120
           DRH   F ++L Y R  GKL     +C   F  E+ +WG++   +E CC    R+  D  
Sbjct: 138 DRHPGVFAYVLNYYRT-GKLHCPADVCGPLFEEELGFWGIDETDVEACCWMTYRQHRDAE 196

Query: 121 SDTYTFYSADEPGVLGR------------DEAR--------------------------- 141
               +F + D  G                DEA                            
Sbjct: 197 EALDSFEAPDPAGAANAANAAGAHDGGLDDEAGAGGGGLDGAGGELKRLCFQDAGGGAGG 256

Query: 142 -PGGAEAAPS---RRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCASTLPDWR 197
            PGGA  A     RRW  R+   FE+P SS AA+ +A  S+ F+++S+   C  T   + 
Sbjct: 257 PPGGAGGAGGTWWRRWQPRVWALFEDPYSSRAARYVAFASLFFILISITTFCLETHEGFI 316

Query: 198 NAAADNRSLDDRSRYSAGPGREPSGI----------IEAICIGWFTAECIVRFIVSKNKC 247
           + +  N+++   S     P    + +          +E +C+ WFT E ++R     +K 
Sbjct: 317 HIS--NKTVTQASPIPGAPPENITNVEVETEPFLTYVEGVCVVWFTFEFLMRITFCPDKV 374

Query: 248 EFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVT-LRVLRMMRIFWVIKLARHF 306
           EF+K  LNIID +AI P+Y+ V ++   G +S+  +  +  LRV+R +RI  + KL RHF
Sbjct: 375 EFLKSSLNIIDCVAILPFYLEVGLS---GLSSKAAKDVLGFLRVVRFVRILRIFKLTRHF 431

Query: 307 IGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEH-GLD----LETSNKDFTSIP 361
           +GL+ LG TL+    E ++L++F+ + + IF+ +    E  G D    L +++  F +IP
Sbjct: 432 VGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERIGADPDDILGSNHTYFKNIP 491

Query: 362 AACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCY 416
              WW +++MTT+GYGDMYP T  G ++G +C ++G++ +A+P+  I ++F   Y
Sbjct: 492 IGFWWAVVTMTTLGYGDMYPKTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 546


>gi|5031819 potassium voltage-gated channel, shaker-related
           subfamily, member 10 [Homo sapiens]
          Length = 511

 Score =  211 bits (538), Expect = 8e-55
 Identities = 133/418 (31%), Positives = 217/418 (51%), Gaps = 43/418 (10%)

Query: 7   GAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRH 66
           G   V++N+ G R+      L  FP      L G R +R        +D  RNEYFFDR+
Sbjct: 84  GNQRVIINIAGLRFETQLRTLSQFP----ETLLGDREKR-----MQFFDSMRNEYFFDRN 134

Query: 67  SEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTYTF 126
             +F  IL Y +  GK+R    +    F +E+ ++ L    +         D+  +   F
Sbjct: 135 RPSFDGILYYYQSGGKIRRPANVPIDIFADEISFYELGSEAM---------DQFREDEGF 185

Query: 127 YSADEPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMV 186
               E  +   D  R         + WL      FE P SS AA+ +A VSV+ V++S+ 
Sbjct: 186 IKDPETLLPTNDIHR---------QFWL-----LFEYPESSSAARAVAVVSVLVVVISIT 231

Query: 187 VLCASTLPDWRN-----AAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIVRFI 241
           + C  TLP++R         D      ++  S     +P  ++E+ CI WFT E ++RF+
Sbjct: 232 IFCLETLPEFREDRELKVVRDPNLNMSKTVLSQTMFTDPFFMVESTCIVWFTFELVLRFV 291

Query: 242 VSKNKCEFVKRPLNIIDLLAITPYYISVLMTVF--TGENSQLQRAGVTLRVLRMMRIFWV 299
           V  +K +F +  +NIID+++I PY+ +++  +   T  ++Q   +   LR++R++R+F +
Sbjct: 292 VCPSKTDFFRNIMNIIDIISIIPYFATLITELVQETEPSAQQNMSLAILRIIRLVRVFRI 351

Query: 300 IKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTS 359
            KL+RH  GLQ LG TLK   RE+ +L+ F+ + + +FS+     E    ++     F+S
Sbjct: 352 FKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE----VDEPESHFSS 407

Query: 360 IPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYH 417
           IP   WW +++MTTVGYGDM P T  G+I+G +C ++G++ +ALP+  I  +F   YH
Sbjct: 408 IPDGFWWAVVTMTTVGYGDMCPTTPGGKIVGTLCAIAGVLTIALPVPVIVSNFNYFYH 465


>gi|88758576 Shaw-related voltage-gated potassium channel protein 4
           isoform c [Homo sapiens]
          Length = 626

 Score =  210 bits (534), Expect = 2e-54
 Identities = 146/446 (32%), Positives = 222/446 (49%), Gaps = 44/446 (9%)

Query: 11  VVLNVGGARYSLSRELLKDFPLRRVSRLH----GCRSERDVLEVCDDYDRERN--EYFFD 64
           +++NVGG R+   R  L+  P  R++ L     G R E D   V           E+FFD
Sbjct: 38  IIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFD 97

Query: 65  RHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCC---QRRLDDRMS 121
           RH   F ++L Y R  GKL     +C   F  E+ +WG++   +E CC    R+  D   
Sbjct: 98  RHPGVFAYVLNYYRT-GKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEE 156

Query: 122 DTYTFYSADEPGV-------------------LGRDEARPG-GAEAAPSRRWLERMRRTF 161
               F S D  G                    LG  E   G GA +   R W  RM   F
Sbjct: 157 ALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALF 216

Query: 162 EEPTSSLAAQILASVSVVFVIVSMVVLCASTLPDW---RNAAADNRSLDDRS-RYSAGPG 217
           E+P SS AA+++A  S+ F++VS+   C  T   +   RN     R  +  S  +     
Sbjct: 217 EDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVE 276

Query: 218 REPS-GIIEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTG 276
            EP    IE +C+ WFT E +VR +   +  +FVK  LNIID +AI P+Y+ V ++   G
Sbjct: 277 TEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLS---G 333

Query: 277 ENSQLQRAGVT-LRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMA 335
            +S+  R  +  LRV+R +RI  + KL RHF+GL+ LG TL+    E ++L++F+ + + 
Sbjct: 334 LSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVL 393

Query: 336 IFSALSQLLEH-----GLDLETSNKDFTSIPAACWWVIISMTTVGYGDMYPITVPGRILG 390
           IF+ +    E             + DF +IP   WW +++MTT+GYGDMYP T  G ++G
Sbjct: 394 IFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVG 453

Query: 391 GVCVVSGIVLLALPITFIYHSFVQCY 416
            +C ++G++ +A+P+  I ++F   Y
Sbjct: 454 ALCALAGVLTIAMPVPVIVNNFGMYY 479


>gi|24497462 Shaw-related voltage-gated potassium channel protein 4
           isoform a [Homo sapiens]
          Length = 635

 Score =  210 bits (534), Expect = 2e-54
 Identities = 146/446 (32%), Positives = 222/446 (49%), Gaps = 44/446 (9%)

Query: 11  VVLNVGGARYSLSRELLKDFPLRRVSRLH----GCRSERDVLEVCDDYDRERN--EYFFD 64
           +++NVGG R+   R  L+  P  R++ L     G R E D   V           E+FFD
Sbjct: 38  IIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFD 97

Query: 65  RHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCC---QRRLDDRMS 121
           RH   F ++L Y R  GKL     +C   F  E+ +WG++   +E CC    R+  D   
Sbjct: 98  RHPGVFAYVLNYYRT-GKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEE 156

Query: 122 DTYTFYSADEPGV-------------------LGRDEARPG-GAEAAPSRRWLERMRRTF 161
               F S D  G                    LG  E   G GA +   R W  RM   F
Sbjct: 157 ALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALF 216

Query: 162 EEPTSSLAAQILASVSVVFVIVSMVVLCASTLPDW---RNAAADNRSLDDRS-RYSAGPG 217
           E+P SS AA+++A  S+ F++VS+   C  T   +   RN     R  +  S  +     
Sbjct: 217 EDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVE 276

Query: 218 REPS-GIIEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTG 276
            EP    IE +C+ WFT E +VR +   +  +FVK  LNIID +AI P+Y+ V ++   G
Sbjct: 277 TEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLS---G 333

Query: 277 ENSQLQRAGVT-LRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMA 335
            +S+  R  +  LRV+R +RI  + KL RHF+GL+ LG TL+    E ++L++F+ + + 
Sbjct: 334 LSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVL 393

Query: 336 IFSALSQLLEH-----GLDLETSNKDFTSIPAACWWVIISMTTVGYGDMYPITVPGRILG 390
           IF+ +    E             + DF +IP   WW +++MTT+GYGDMYP T  G ++G
Sbjct: 394 IFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVG 453

Query: 391 GVCVVSGIVLLALPITFIYHSFVQCY 416
            +C ++G++ +A+P+  I ++F   Y
Sbjct: 454 ALCALAGVLTIAMPVPVIVNNFGMYY 479


>gi|24497464 Shaw-related voltage-gated potassium channel protein 4
           isoform b [Homo sapiens]
          Length = 582

 Score =  210 bits (534), Expect = 2e-54
 Identities = 146/446 (32%), Positives = 222/446 (49%), Gaps = 44/446 (9%)

Query: 11  VVLNVGGARYSLSRELLKDFPLRRVSRLH----GCRSERDVLEVCDDYDRERN--EYFFD 64
           +++NVGG R+   R  L+  P  R++ L     G R E D   V           E+FFD
Sbjct: 38  IIINVGGTRHETYRSTLRTLPGTRLAWLADPDGGGRPETDGGGVGSSGSSGGGGCEFFFD 97

Query: 65  RHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCC---QRRLDDRMS 121
           RH   F ++L Y R  GKL     +C   F  E+ +WG++   +E CC    R+  D   
Sbjct: 98  RHPGVFAYVLNYYRT-GKLHCPADVCGPLFEEELTFWGIDETDVEPCCWMTYRQHRDAEE 156

Query: 122 DTYTFYSADEPGV-------------------LGRDEARPG-GAEAAPSRRWLERMRRTF 161
               F S D  G                    LG  E   G GA +   R W  RM   F
Sbjct: 157 ALDIFESPDGGGSGAGPSDEAGDDERELALQRLGPHEGGAGHGAGSGGCRGWQPRMWALF 216

Query: 162 EEPTSSLAAQILASVSVVFVIVSMVVLCASTLPDW---RNAAADNRSLDDRS-RYSAGPG 217
           E+P SS AA+++A  S+ F++VS+   C  T   +   RN     R  +  S  +     
Sbjct: 217 EDPYSSRAARVVAFASLFFILVSITTFCLETHEAFNIDRNVTEILRVGNITSVHFRREVE 276

Query: 218 REPS-GIIEAICIGWFTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFTG 276
            EP    IE +C+ WFT E +VR +   +  +FVK  LNIID +AI P+Y+ V ++   G
Sbjct: 277 TEPILTYIEGVCVLWFTLEFLVRIVCCPDTLDFVKNLLNIIDFVAILPFYLEVGLS---G 333

Query: 277 ENSQLQRAGVT-LRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMA 335
            +S+  R  +  LRV+R +RI  + KL RHF+GL+ LG TL+    E ++L++F+ + + 
Sbjct: 334 LSSKAARDVLGFLRVVRFVRILRIFKLTRHFVGLRVLGHTLRASTNEFLLLIIFLALGVL 393

Query: 336 IFSALSQLLEH-----GLDLETSNKDFTSIPAACWWVIISMTTVGYGDMYPITVPGRILG 390
           IF+ +    E             + DF +IP   WW +++MTT+GYGDMYP T  G ++G
Sbjct: 394 IFATMIYYAERIGARPSDPRGNDHTDFKNIPIGFWWAVVTMTTLGYGDMYPKTWSGMLVG 453

Query: 391 GVCVVSGIVLLALPITFIYHSFVQCY 416
            +C ++G++ +A+P+  I ++F   Y
Sbjct: 454 ALCALAGVLTIAMPVPVIVNNFGMYY 479


>gi|27436981 potassium voltage-gated channel, Shal-related
           subfamily, member 1 [Homo sapiens]
          Length = 647

 Score =  209 bits (533), Expect = 3e-54
 Identities = 136/413 (32%), Positives = 218/413 (52%), Gaps = 34/413 (8%)

Query: 7   GAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRH 66
           G   +V+NV G R+   +  L  +P      L G  SE++       YD +  EYFFDR 
Sbjct: 38  GDEVLVVNVSGRRFETWKNTLDRYP----DTLLGS-SEKEFF-----YDADSGEYFFDRD 87

Query: 67  SEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTYTF 126
            + F  +L + R  G+L    + C  +F  E+ ++GL    +  CC     DR  +    
Sbjct: 88  PDMFRHVLNFYRT-GRLHCPRQECIQAFDEELAFYGLVPELVGDCCLEEYRDRKKENAER 146

Query: 127 YSADEPGVLGRDEARPGGAEAAPSRRWL-ERMRRTFEEPTSSLAAQILASVSVVFVIVSM 185
            + DE      +  + G   A P+   L +R+ R FE P +S AA +   V+  F+ VS+
Sbjct: 147 LAEDE------EAEQAGDGPALPAGSSLRQRLWRAFENPHTSTAALVFYYVTGFFIAVSV 200

Query: 186 VVLCASTLPDWRNAAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIVRFIVSKN 245
           +     T+P   +A   +R      R+      +    ++  C+  FT E ++R   + +
Sbjct: 201 IANVVETIPCRGSARRSSREQPCGERFP-----QAFFCMDTACVLIFTGEYLLRLFAAPS 255

Query: 246 KCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVIKLARH 305
           +C F++  +++ID++AI PYYI +L+     +N  +  A VTLRV R+ RIF   K +RH
Sbjct: 256 RCRFLRSVMSLIDVVAILPYYIGLLVP----KNDDVSGAFVTLRVFRVFRIF---KFSRH 308

Query: 306 FIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSIPAACW 365
             GL+ LG TLK C  E+  LL  + +A+ IF+ +    E G    T+  +FTSIPAA W
Sbjct: 309 SQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKG----TNKTNFTSIPAAFW 364

Query: 366 WVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHE 418
           + I++MTT+GYGDM P T+ G+I G +C +SG++++ALP+  I  +F + YH+
Sbjct: 365 YTIVTMTTLGYGDMVPSTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQ 417


>gi|9789987 potassium voltage-gated channel, Shal-related subfamily,
           member 2 [Homo sapiens]
          Length = 630

 Score =  209 bits (531), Expect = 5e-54
 Identities = 139/414 (33%), Positives = 215/414 (51%), Gaps = 35/414 (8%)

Query: 5   RSGAASVVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFD 64
           R+  A +VLNV G R+   ++ L+ +P      L G  SERD       Y  E  +YFFD
Sbjct: 37  RTQDALIVLNVSGTRFQTWQDTLERYP----DTLLGS-SERDFF-----YHPETQQYFFD 86

Query: 65  RHSEAFGFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTY 124
           R  + F  IL + R  GKL +    C  ++  E+ ++GL    +  CC     DR  +  
Sbjct: 87  RDPDIFRHILNFYRT-GKLHYPRHECISAYDEELAFFGLIPEIIGDCCYEEYKDRRRENA 145

Query: 125 TFYSADEPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVS 184
                D        +    G  A P+    +R+ R FE P +S  A +   V+  F+ VS
Sbjct: 146 ERLQDDA-------DTDTAGESALPTMTARQRVWRAFENPHTSTMALVFYYVTGFFIAVS 198

Query: 185 MVVLCASTLPDWRNAAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIVRFIVSK 244
           ++     T+P   ++    + L    RY+          ++  C+  FT E ++R   + 
Sbjct: 199 VIANVVETVP-CGSSPGHIKELPCGERYAVA-----FFCLDTACVMIFTVEYLLRLAAAP 252

Query: 245 NKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVTLRVLRMMRIFWVIKLAR 304
           ++  FV+  ++IID++AI PYYI ++MT    +N  +  A VTLRV R+ RIF   K +R
Sbjct: 253 SRYRFVRSVMSIIDVVAILPYYIGLVMT----DNEDVSGAFVTLRVFRVFRIF---KFSR 305

Query: 305 HFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDFTSIPAAC 364
           H  GL+ LG TLK C  E+  LL  + +A+ IF+ +    E G    +S   FTSIPAA 
Sbjct: 306 HSQGLRILGYTLKSCASELGFLLFSLTMAIIIFATVMFYAEKG----SSASKFTSIPAAF 361

Query: 365 WWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYHE 418
           W+ I++MTT+GYGDM P T+ G+I G +C +SG++++ALP+  I  +F + YH+
Sbjct: 362 WYTIVTMTTLGYGDMVPKTIAGKIFGSICSLSGVLVIALPVPVIVSNFSRIYHQ 415


>gi|4504817 potassium voltage-gated channel, shaker-related
           subfamily, member 4 [Homo sapiens]
          Length = 653

 Score =  207 bits (528), Expect = 1e-53
 Identities = 143/431 (33%), Positives = 223/431 (51%), Gaps = 64/431 (14%)

Query: 11  VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAF 70
           VV+NV G R+    + L  FP      L G   +R        +D  RNEYFFDR+  +F
Sbjct: 178 VVINVSGLRFETQMKTLAQFP----ETLLGDPEKRTQY-----FDPLRNEYFFDRNRPSF 228

Query: 71  GFILLYVRGHGKLRFAPRMCELSFYNEMIYWGL-EGAHLEYCCQRRLDDRMSDTYTFYSA 129
             IL Y +  G+L+    +    F  E+ ++ L E A L++                   
Sbjct: 229 DAILYYYQSGGRLKRPVNVPFDIFTEEVKFYQLGEEALLKF------------------R 270

Query: 130 DEPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLC 189
           ++ G +  +E R     A P   + +++   FE P SS  A+ +A VSV+ +++S+V+ C
Sbjct: 271 EDEGFVREEEDR-----ALPENEFKKQIWLLFEYPESSSPARGIAIVSVLVILISIVIFC 325

Query: 190 ASTLPDWRN---------AAADNRSLDDRSRYSAGPGREPSG---------IIEAICIGW 231
             TLP++R+         A      L+D S     P  E SG         I+E +CI W
Sbjct: 326 LETLPEFRDDRDLVMALSAGGHGGLLNDTS----APHLENSGHTIFNDPFFIVETVCIVW 381

Query: 232 FTAECIVRFIVSKNKCEFVKRPLNIIDLLAITPYYISV---LMTVFTGENSQLQRAG--V 286
           F+ E +VR     ++  F K  +NIID+++I PY+I++   L     G N Q Q+A    
Sbjct: 382 FSFEFVVRCFACPSQALFFKNIMNIIDIVSILPYFITLGTDLAQQQGGGNGQQQQAMSFA 441

Query: 287 TLRVLRMMRIFWVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEH 346
            LR++R++R+F + KL+RH  GLQ LG TL+   RE+ +L+ F+ + + +FS+     E 
Sbjct: 442 ILRIIRLVRVFRIFKLSRHSKGLQILGHTLRASMRELGLLIFFLFIGVILFSSAVYFAE- 500

Query: 347 GLDLETSNKDFTSIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPIT 406
               +     F SIP A WW +++MTTVGYGDM PITV G+I+G +C ++G++ +ALP+ 
Sbjct: 501 ---ADEPTTHFQSIPDAFWWAVVTMTTVGYGDMKPITVGGKIVGSLCAIAGVLTIALPVP 557

Query: 407 FIYHSFVQCYH 417
            I  +F   YH
Sbjct: 558 VIVSNFNYFYH 568


>gi|4826782 potassium voltage-gated channel, shaker-related
           subfamily, member 2 [Homo sapiens]
          Length = 499

 Score =  207 bits (527), Expect = 2e-53
 Identities = 138/420 (32%), Positives = 214/420 (50%), Gaps = 49/420 (11%)

Query: 11  VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVCDDYDRERNEYFFDRHSEAF 70
           VV+N+ G R+    + L  FP      L G   +R        +D  RNEYFFDR+  +F
Sbjct: 35  VVINISGLRFETQLKTLAQFP----ETLLGDPKKR-----MRYFDPLRNEYFFDRNRPSF 85

Query: 71  GFILLYVRGHGKLRFAPRMCELSFYNEMIYWGLEGAHLEYCCQRRLDDRMSDTYTFYSAD 130
             IL Y +  G+LR  P    L  ++E I               R  +   +    +  D
Sbjct: 86  DAILYYYQSGGRLR-RPVNVPLDIFSEEI---------------RFYELGEEAMEMFRED 129

Query: 131 EPGVLGRDEARPGGAEAAPSRRWLERMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCA 190
           E  +  ++E RP      P   +  ++   FE P SS  A+I+A VSV+ +++S+V  C 
Sbjct: 130 EGYI--KEEERP-----LPENEFQRQVWLLFEYPESSGPARIIAIVSVMVILISIVSFCL 182

Query: 191 STLPDWRNAAADNR----SLDDRSRYSAGPGR-----EPSGIIEAICIGWFTAECIVRFI 241
            TLP +R+   D      +    S  + G  +     +P  I+E +CI WF+ E +VRF 
Sbjct: 183 ETLPIFRDENEDMHGSGVTFHTYSNSTIGYQQSTSFTDPFFIVETLCIIWFSFEFLVRFF 242

Query: 242 VSKNKCEFVKRPLNIIDLLAITPYYISVLMTVFT----GENSQLQRAGVTLRVLRMMRIF 297
              +K  F    +NIID++AI PY+I++   +       +  Q   +   LRV+R++R+F
Sbjct: 243 ACPSKAGFFTNIMNIIDIVAIIPYFITLGTELAEKPEDAQQGQQAMSLAILRVIRLVRVF 302

Query: 298 WVIKLARHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEHGLDLETSNKDF 357
            + KL+RH  GLQ LG TLK   RE+ +L+ F+ + + +FS+     E     +     F
Sbjct: 303 RIFKLSRHSKGLQILGQTLKASMRELGLLIFFLFIGVILFSSAVYFAE----ADERESQF 358

Query: 358 TSIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCYH 417
            SIP A WW ++SMTTVGYGDM P T+ G+I+G +C ++G++ +ALP+  I  +F   YH
Sbjct: 359 PSIPDAFWWAVVSMTTVGYGDMVPTTIGGKIVGSLCAIAGVLTIALPVPVIVSNFNYFYH 418


>gi|21217561 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2a [Homo sapiens]
          Length = 613

 Score =  206 bits (524), Expect = 3e-53
 Identities = 142/478 (29%), Positives = 222/478 (46%), Gaps = 79/478 (16%)

Query: 11  VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVC------------------- 51
           V+LNVGG R+   R  LK  P  R++ L       D L                      
Sbjct: 10  VILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPRAPP 69

Query: 52  -----------------------DDYDRERNEYFFDRHSEAFGFILLYVRGHGKLRFAPR 88
                                   D+     E+FFDRH   F ++L Y R  GKL     
Sbjct: 70  LSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT-GKLHCPAD 128

Query: 89  MCELSFYNEMIYWGLEGAHLEYCC---QRRLDDRMSDTYTFYSAD----EPGV------- 134
           +C   F  E+ +WG++   +E CC    R+  D       F + D    +PG        
Sbjct: 129 VCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPGDDEDLAAK 188

Query: 135 -LGRDEARPGGAEAAPSRRWLE---RMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCA 190
            LG ++A   G     S RW     RM   FE+P SS AA+ +A  S+ F++VS+   C 
Sbjct: 189 RLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFCL 248

Query: 191 ST------LPDWRNAAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIVRFIVSK 244
            T      + +      +  S+  +      P       +E +C+ WFT E +VR + S 
Sbjct: 249 ETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALT---YVEGVCVVWFTFEFLVRIVFSP 305

Query: 245 NKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVT-LRVLRMMRIFWVIKLA 303
           NK EF+K  LNIID +AI P+Y+ V ++   G +S+  +  +  LRV+R +RI  + KL 
Sbjct: 306 NKLEFIKNLLNIIDFVAILPFYLEVGLS---GLSSKAAKDVLGFLRVVRFVRILRIFKLT 362

Query: 304 RHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEH-----GLDLETSNKDFT 358
           RHF+GL+ LG TL+    E ++L++F+ + + IF+ +    E           + +  F 
Sbjct: 363 RHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFK 422

Query: 359 SIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCY 416
           +IP   WW +++MTT+GYGDMYP T  G ++G +C ++G++ +A+P+  I ++F   Y
Sbjct: 423 NIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480


>gi|21217563 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2b [Homo sapiens]
          Length = 638

 Score =  206 bits (524), Expect = 3e-53
 Identities = 142/478 (29%), Positives = 222/478 (46%), Gaps = 79/478 (16%)

Query: 11  VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVC------------------- 51
           V+LNVGG R+   R  LK  P  R++ L       D L                      
Sbjct: 10  VILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPRAPP 69

Query: 52  -----------------------DDYDRERNEYFFDRHSEAFGFILLYVRGHGKLRFAPR 88
                                   D+     E+FFDRH   F ++L Y R  GKL     
Sbjct: 70  LSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT-GKLHCPAD 128

Query: 89  MCELSFYNEMIYWGLEGAHLEYCC---QRRLDDRMSDTYTFYSAD----EPGV------- 134
           +C   F  E+ +WG++   +E CC    R+  D       F + D    +PG        
Sbjct: 129 VCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPGDDEDLAAK 188

Query: 135 -LGRDEARPGGAEAAPSRRWLE---RMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCA 190
            LG ++A   G     S RW     RM   FE+P SS AA+ +A  S+ F++VS+   C 
Sbjct: 189 RLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFCL 248

Query: 191 ST------LPDWRNAAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIVRFIVSK 244
            T      + +      +  S+  +      P       +E +C+ WFT E +VR + S 
Sbjct: 249 ETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALT---YVEGVCVVWFTFEFLVRIVFSP 305

Query: 245 NKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVT-LRVLRMMRIFWVIKLA 303
           NK EF+K  LNIID +AI P+Y+ V ++   G +S+  +  +  LRV+R +RI  + KL 
Sbjct: 306 NKLEFIKNLLNIIDFVAILPFYLEVGLS---GLSSKAAKDVLGFLRVVRFVRILRIFKLT 362

Query: 304 RHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEH-----GLDLETSNKDFT 358
           RHF+GL+ LG TL+    E ++L++F+ + + IF+ +    E           + +  F 
Sbjct: 363 RHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFK 422

Query: 359 SIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCY 416
           +IP   WW +++MTT+GYGDMYP T  G ++G +C ++G++ +A+P+  I ++F   Y
Sbjct: 423 NIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480


>gi|24497458 Shaw-related voltage-gated potassium channel protein 2
           isoform KV3.2c [Homo sapiens]
          Length = 558

 Score =  206 bits (524), Expect = 3e-53
 Identities = 142/478 (29%), Positives = 222/478 (46%), Gaps = 79/478 (16%)

Query: 11  VVLNVGGARYSLSRELLKDFPLRRVSRLHGCRSERDVLEVC------------------- 51
           V+LNVGG R+   R  LK  P  R++ L       D L                      
Sbjct: 10  VILNVGGTRHETYRSTLKTLPGTRLALLASSEPPGDCLTTAGDKLQPSPPPLSPPPRAPP 69

Query: 52  -----------------------DDYDRERNEYFFDRHSEAFGFILLYVRGHGKLRFAPR 88
                                   D+     E+FFDRH   F ++L Y R  GKL     
Sbjct: 70  LSPGPGGCFEGGAGNCSSRGGRASDHPGGGREFFFDRHPGVFAYVLNYYRT-GKLHCPAD 128

Query: 89  MCELSFYNEMIYWGLEGAHLEYCC---QRRLDDRMSDTYTFYSAD----EPGV------- 134
           +C   F  E+ +WG++   +E CC    R+  D       F + D    +PG        
Sbjct: 129 VCGPLFEEELAFWGIDETDVEPCCWMTYRQHRDAEEALDIFETPDLIGGDPGDDEDLAAK 188

Query: 135 -LGRDEARPGGAEAAPSRRWLE---RMRRTFEEPTSSLAAQILASVSVVFVIVSMVVLCA 190
            LG ++A   G     S RW     RM   FE+P SS AA+ +A  S+ F++VS+   C 
Sbjct: 189 RLGIEDAAGLGGPDGKSGRWRRLQPRMWALFEDPYSSRAARFIAFASLFFILVSITTFCL 248

Query: 191 ST------LPDWRNAAADNRSLDDRSRYSAGPGREPSGIIEAICIGWFTAECIVRFIVSK 244
            T      + +      +  S+  +      P       +E +C+ WFT E +VR + S 
Sbjct: 249 ETHEAFNIVKNKTEPVINGTSVVLQYEIETDPALT---YVEGVCVVWFTFEFLVRIVFSP 305

Query: 245 NKCEFVKRPLNIIDLLAITPYYISVLMTVFTGENSQLQRAGVT-LRVLRMMRIFWVIKLA 303
           NK EF+K  LNIID +AI P+Y+ V ++   G +S+  +  +  LRV+R +RI  + KL 
Sbjct: 306 NKLEFIKNLLNIIDFVAILPFYLEVGLS---GLSSKAAKDVLGFLRVVRFVRILRIFKLT 362

Query: 304 RHFIGLQTLGLTLKRCYREMVMLLVFICVAMAIFSALSQLLEH-----GLDLETSNKDFT 358
           RHF+GL+ LG TL+    E ++L++F+ + + IF+ +    E           + +  F 
Sbjct: 363 RHFVGLRVLGHTLRASTNEFLLLIIFLALGVLIFATMIYYAERVGAQPNDPSASEHTQFK 422

Query: 359 SIPAACWWVIISMTTVGYGDMYPITVPGRILGGVCVVSGIVLLALPITFIYHSFVQCY 416
           +IP   WW +++MTT+GYGDMYP T  G ++G +C ++G++ +A+P+  I ++F   Y
Sbjct: 423 NIPIGFWWAVVTMTTLGYGDMYPQTWSGMLVGALCALAGVLTIAMPVPVIVNNFGMYY 480


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.328    0.140    0.437 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 15,565,146
Number of Sequences: 37866
Number of extensions: 655967
Number of successful extensions: 2275
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 80
Number of HSP's successfully gapped in prelim test: 40
Number of HSP's that attempted gapping in prelim test: 1908
Number of HSP's gapped (non-prelim): 221
length of query: 436
length of database: 18,247,518
effective HSP length: 105
effective length of query: 331
effective length of database: 14,271,588
effective search space: 4723895628
effective search space used: 4723895628
T: 11
A: 40
X1: 15 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.7 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.