Search of human proteins with 190194423

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|190194423 SPARC-like 1 [Homo sapiens]
         (664 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|190194423 SPARC-like 1 [Homo sapiens]                             1369   0.0  
gi|190341024 SPARC-like 1 [Homo sapiens]                             1369   0.0  
gi|4507171 secreted protein, acidic, cysteine-rich [Homo sapiens]     324   1e-88
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    76   1e-13
gi|93141003 testican 3 isoform 1 [Homo sapiens]                        68   2e-11
gi|93141001 testican 3 isoform 2 [Homo sapiens]                        68   2e-11
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              67   5e-11
gi|20270337 Leo1, Paf1/RNA polymerase II complex component, homo...    65   2e-10
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    65   2e-10
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1...    64   4e-10
gi|217330641 IWS1 homolog [Homo sapiens]                               63   8e-10
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    63   1e-09
gi|24415404 MDN1, midasin homolog [Homo sapiens]                       62   2e-09
gi|4504487 histidine rich calcium binding protein precursor [Hom...    60   5e-09
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                       60   8e-09
gi|13540523 nucleosomal binding protein 1 [Homo sapiens]               59   1e-08
gi|5031701 follistatin-like 3 glycoprotein precursor [Homo sapiens]    59   1e-08
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof...    59   1e-08
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof...    59   2e-08
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof...    59   2e-08
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]     58   2e-08
gi|253970456 HIV-1 Tat specific factor 1 [Homo sapiens]                58   3e-08
gi|21361437 HIV-1 Tat specific factor 1 [Homo sapiens]                 58   3e-08
gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2 pre...    58   3e-08
gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1 precu...    57   4e-08
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi...    57   4e-08
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof...    57   4e-08
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof...    57   4e-08
gi|60097902 filaggrin [Homo sapiens]                                   56   9e-08
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    56   1e-07

>gi|190194423 SPARC-like 1 [Homo sapiens]
          Length = 664

 Score = 1369 bits (3544), Expect = 0.0
 Identities = 664/664 (100%), Positives = 664/664 (100%)

Query: 1   MKTGLFFLCLLGTAAAIPTNARLLSDHSKPTAETVAPDNTAIPSLRAEAEENEKETAVST 60
           MKTGLFFLCLLGTAAAIPTNARLLSDHSKPTAETVAPDNTAIPSLRAEAEENEKETAVST
Sbjct: 1   MKTGLFFLCLLGTAAAIPTNARLLSDHSKPTAETVAPDNTAIPSLRAEAEENEKETAVST 60

Query: 61  EDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTL 120
           EDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTL
Sbjct: 61  EDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTL 120

Query: 121 DIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSK 180
           DIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSK
Sbjct: 121 DIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSK 180

Query: 181 HSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPREHANSKQEEDNTQS 240
           HSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPREHANSKQEEDNTQS
Sbjct: 181 HSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPREHANSKQEEDNTQS 240

Query: 241 DDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKT 300
           DDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKT
Sbjct: 241 DDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKT 300

Query: 301 GLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDD 360
           GLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDD
Sbjct: 301 GLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDD 360

Query: 361 YFIPSQAFLEAERAQSIAYHLKIEEQREKVHENENIGTTEPGEHQEAKKAENSSNEEETS 420
           YFIPSQAFLEAERAQSIAYHLKIEEQREKVHENENIGTTEPGEHQEAKKAENSSNEEETS
Sbjct: 361 YFIPSQAFLEAERAQSIAYHLKIEEQREKVHENENIGTTEPGEHQEAKKAENSSNEEETS 420

Query: 421 SEGNMRVHAVDSCMSFQCKRGHICKADQQGKPHCVCQDPVTCPPTKPLDQVCGTDNQTYA 480
           SEGNMRVHAVDSCMSFQCKRGHICKADQQGKPHCVCQDPVTCPPTKPLDQVCGTDNQTYA
Sbjct: 421 SEGNMRVHAVDSCMSFQCKRGHICKADQQGKPHCVCQDPVTCPPTKPLDQVCGTDNQTYA 480

Query: 481 SSCHLFATKCRLEGTKKGHQLQLDYFGACKSIPTCTDFEVIQFPLRMRDWLKNILMQLYE 540
           SSCHLFATKCRLEGTKKGHQLQLDYFGACKSIPTCTDFEVIQFPLRMRDWLKNILMQLYE
Sbjct: 481 SSCHLFATKCRLEGTKKGHQLQLDYFGACKSIPTCTDFEVIQFPLRMRDWLKNILMQLYE 540

Query: 541 ANSEHAGYLNEKQRNKVKKIYLDEKRLLAGDHPIDLLLRDFKKNYHMYVYPVHWQFSELD 600
           ANSEHAGYLNEKQRNKVKKIYLDEKRLLAGDHPIDLLLRDFKKNYHMYVYPVHWQFSELD
Sbjct: 541 ANSEHAGYLNEKQRNKVKKIYLDEKRLLAGDHPIDLLLRDFKKNYHMYVYPVHWQFSELD 600

Query: 601 QHPMDRVLTHSELAPLRASLVPMEHCITRFFEECDPNKDKHITLKEWGHCFGIKEEDIDE 660
           QHPMDRVLTHSELAPLRASLVPMEHCITRFFEECDPNKDKHITLKEWGHCFGIKEEDIDE
Sbjct: 601 QHPMDRVLTHSELAPLRASLVPMEHCITRFFEECDPNKDKHITLKEWGHCFGIKEEDIDE 660

Query: 661 NLLF 664
           NLLF
Sbjct: 661 NLLF 664


>gi|190341024 SPARC-like 1 [Homo sapiens]
          Length = 664

 Score = 1369 bits (3544), Expect = 0.0
 Identities = 664/664 (100%), Positives = 664/664 (100%)

Query: 1   MKTGLFFLCLLGTAAAIPTNARLLSDHSKPTAETVAPDNTAIPSLRAEAEENEKETAVST 60
           MKTGLFFLCLLGTAAAIPTNARLLSDHSKPTAETVAPDNTAIPSLRAEAEENEKETAVST
Sbjct: 1   MKTGLFFLCLLGTAAAIPTNARLLSDHSKPTAETVAPDNTAIPSLRAEAEENEKETAVST 60

Query: 61  EDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTL 120
           EDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTL
Sbjct: 61  EDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTL 120

Query: 121 DIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSK 180
           DIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSK
Sbjct: 121 DIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSK 180

Query: 181 HSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPREHANSKQEEDNTQS 240
           HSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPREHANSKQEEDNTQS
Sbjct: 181 HSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPREHANSKQEEDNTQS 240

Query: 241 DDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKT 300
           DDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKT
Sbjct: 241 DDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKT 300

Query: 301 GLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDD 360
           GLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDD
Sbjct: 301 GLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDD 360

Query: 361 YFIPSQAFLEAERAQSIAYHLKIEEQREKVHENENIGTTEPGEHQEAKKAENSSNEEETS 420
           YFIPSQAFLEAERAQSIAYHLKIEEQREKVHENENIGTTEPGEHQEAKKAENSSNEEETS
Sbjct: 361 YFIPSQAFLEAERAQSIAYHLKIEEQREKVHENENIGTTEPGEHQEAKKAENSSNEEETS 420

Query: 421 SEGNMRVHAVDSCMSFQCKRGHICKADQQGKPHCVCQDPVTCPPTKPLDQVCGTDNQTYA 480
           SEGNMRVHAVDSCMSFQCKRGHICKADQQGKPHCVCQDPVTCPPTKPLDQVCGTDNQTYA
Sbjct: 421 SEGNMRVHAVDSCMSFQCKRGHICKADQQGKPHCVCQDPVTCPPTKPLDQVCGTDNQTYA 480

Query: 481 SSCHLFATKCRLEGTKKGHQLQLDYFGACKSIPTCTDFEVIQFPLRMRDWLKNILMQLYE 540
           SSCHLFATKCRLEGTKKGHQLQLDYFGACKSIPTCTDFEVIQFPLRMRDWLKNILMQLYE
Sbjct: 481 SSCHLFATKCRLEGTKKGHQLQLDYFGACKSIPTCTDFEVIQFPLRMRDWLKNILMQLYE 540

Query: 541 ANSEHAGYLNEKQRNKVKKIYLDEKRLLAGDHPIDLLLRDFKKNYHMYVYPVHWQFSELD 600
           ANSEHAGYLNEKQRNKVKKIYLDEKRLLAGDHPIDLLLRDFKKNYHMYVYPVHWQFSELD
Sbjct: 541 ANSEHAGYLNEKQRNKVKKIYLDEKRLLAGDHPIDLLLRDFKKNYHMYVYPVHWQFSELD 600

Query: 601 QHPMDRVLTHSELAPLRASLVPMEHCITRFFEECDPNKDKHITLKEWGHCFGIKEEDIDE 660
           QHPMDRVLTHSELAPLRASLVPMEHCITRFFEECDPNKDKHITLKEWGHCFGIKEEDIDE
Sbjct: 601 QHPMDRVLTHSELAPLRASLVPMEHCITRFFEECDPNKDKHITLKEWGHCFGIKEEDIDE 660

Query: 661 NLLF 664
           NLLF
Sbjct: 661 NLLF 664


>gi|4507171 secreted protein, acidic, cysteine-rich [Homo sapiens]
          Length = 303

 Score =  324 bits (831), Expect = 1e-88
 Identities = 148/259 (57%), Positives = 190/259 (73%), Gaps = 6/259 (2%)

Query: 406 EAKKAENSSNEEETSSEGNMRVHAVDSCMSFQCKRGHICKADQQGKPHCVCQDPVTCP-P 464
           + +  E     EET  E    V A + C +  CK G +C+ D+   P CVCQDP +CP P
Sbjct: 49  QVEVGEFDDGAEETEEE----VVAENPCQNHHCKHGKVCELDENNTPMCVCQDPTSCPAP 104

Query: 465 TKPLDQVCGTDNQTYASSCHLFATKCRLEGTKKGHQLQLDYFGACKSIPTCTDFEVIQFP 524
               ++VC  DN+T+ SSCH FATKC LEGTKKGH+L LDY G CK IP C D E+ +FP
Sbjct: 105 IGEFEKVCSNDNKTFDSSCHFFATKCTLEGTKKGHKLHLDYIGPCKYIPPCLDSELTEFP 164

Query: 525 LRMRDWLKNILMQLYEANSEHAGYLNEKQRNKVKKIYLDEKRLLAGDHPIDLLLRDFKKN 584
           LRMRDWLKN+L+ LYE + ++   L EKQ+ +VKKI+ +EKRL AGDHP++LL RDF+KN
Sbjct: 165 LRMRDWLKNVLVTLYERDEDN-NLLTEKQKLRVKKIHENEKRLEAGDHPVELLARDFEKN 223

Query: 585 YHMYVYPVHWQFSELDQHPMDRVLTHSELAPLRASLVPMEHCITRFFEECDPNKDKHITL 644
           Y+MY++PVHWQF +LDQHP+D  L+H+ELAPLRA L+PMEHC TRFFE CD + DK+I L
Sbjct: 224 YNMYIFPVHWQFGQLDQHPIDGYLSHTELAPLRAPLIPMEHCTTRFFETCDLDNDKYIAL 283

Query: 645 KEWGHCFGIKEEDIDENLL 663
            EW  CFGIK++DID++L+
Sbjct: 284 DEWAGCFGIKQKDIDKDLV 302



 Score = 30.8 bits (68), Expect = 4.2
 Identities = 24/77 (31%), Positives = 31/77 (40%), Gaps = 12/77 (15%)

Query: 1  MKTGLFF-LCLLGTAAAIPTNARLLSDHSKPTAETVA----------PDNTAIPSLRAEA 49
          M+  +FF LCL G A A P     L D ++   ETVA          P    +      A
Sbjct: 1  MRAWIFFLLCLAGRALAAP-QQEALPDETEVVEETVAEVTEVSVGANPVQVEVGEFDDGA 59

Query: 50 EENEKETAVSTEDDSHH 66
          EE E+E        +HH
Sbjct: 60 EETEEEVVAENPCQNHH 76


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
           sapiens]
          Length = 1152

 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 99/438 (22%), Positives = 169/438 (38%), Gaps = 58/438 (13%)

Query: 31  TAETVAPDNTAIPSLRAEAEEN------EKETAVSTEDDSHH--KAEKSSVLKSKEESHE 82
           T E  + +   IP  +  AE++      E+E   + E+   H  + EK+ +L S + + +
Sbjct: 575 TIEAFSDEEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEIL-SDDLTDK 633

Query: 83  QSAEQGKSSSQELGLKDQEDS-DGHLSVNLEYAPTEGTLDIKEDMSEPQEK--KLSENTD 139
               +GK+ S    + + ED  +G      E    EG+   +    E +EK  K     +
Sbjct: 634 AEVSEGKAKS----VGEAEDGPEGRGDGTCE----EGSSGAEHWQDEEREKGEKDKGRGE 685

Query: 140 FLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSK--------HSQGLRDQGNQ 191
              PG      + ++E   +  E QEQ      HQ  R+ +        H +G  ++G++
Sbjct: 686 MERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDR 745

Query: 192 EQDPNISN-------GEE---EEEKEPGE---------------VGTHNDNQERKTELPR 226
           E++            GEE   E EKE GE                G   + +E +TE   
Sbjct: 746 EEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETE--- 802

Query: 227 EHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNK 286
                K+E    +  ++ E   +  +  +  E E ++G  E+E+    E E E       
Sbjct: 803 GRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEG 862

Query: 287 HIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGVDDDGDDDGD 346
              E E + +EG+   E      E EE+   E    E   +G       G +++G+  G+
Sbjct: 863 EEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGE 922

Query: 347 DGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIEEQREKVHENENIGTTEPGEHQ- 405
           + G +G      ++     +   E E  +        EE+ E   E E  G  E GE + 
Sbjct: 923 EEGEEGEGEGEEEEGEGEGEDG-EGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEG 981

Query: 406 EAKKAENSSNEEETSSEG 423
           E ++ E    EEE   EG
Sbjct: 982 EEEEGEGEGEEEEGEEEG 999



 Score = 69.7 bits (169), Expect = 8e-12
 Identities = 72/375 (19%), Positives = 143/375 (38%), Gaps = 34/375 (9%)

Query: 48   EAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHL 107
            E EE ++E     E +   + E   V   +E+   +  ++ ++  +E G ++ +  +G  
Sbjct: 739  EEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEG-- 796

Query: 108  SVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQ-EQ 166
                E   TEG  + KE+  E +  ++ E             +  ++E   + EE + E+
Sbjct: 797  ----EEEETEGRGEEKEEGGEVEGGEVEEG--------KGEREEEEEEGEGEEEEGEGEE 844

Query: 167  PRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPR 226
                   +        +G   +G +E +     GEEEE +  GE     + +E + E   
Sbjct: 845  EEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEG 904

Query: 227  EH---ANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASN 283
            E       ++EE   + ++  EE +   +  + + +  D   + +E+    E EEE    
Sbjct: 905  EEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEG 964

Query: 284  VNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGVDDDGDD 343
              +  +E E + +EG+   E      E EE+   E    E  ++G       G  ++ ++
Sbjct: 965  EGE--EEGEGEGEEGEGEGEEEEGEGEGEEEEGEE----EGEEEGEGEEEGEGEGEEEEE 1018

Query: 344  DGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIEEQREKVHENENIGTTEPGE 403
               +G  +G                 E E  +      + E + E+   N      E G+
Sbjct: 1019 GEVEGEVEGEEGEGEG----------EEEEGEEEGEEREKEGEGEENRRNREEEEEEEGK 1068

Query: 404  HQEAKKAENSSNEEE 418
            +QE  + EN   + E
Sbjct: 1069 YQETGEEENERQDGE 1083



 Score = 38.5 bits (88), Expect = 0.020
 Identities = 41/211 (19%), Positives = 83/211 (39%), Gaps = 11/211 (5%)

Query: 48   EAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHL 107
            E E  E+E     E++   + E+       EE  E+   +G+   +E G  + ED +G  
Sbjct: 892  EGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGE---EEEGEGEGEDGEG-- 946

Query: 108  SVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQP 167
                E    EG  + +E+  E + ++  E       G     +   +    + EE  E+ 
Sbjct: 947  ----EGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEE 1002

Query: 168  RNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEE-EKEPGEVGTHNDNQERKTELPR 226
                        +  +G   +G  E +     GEEEE E+E  E     + +E +     
Sbjct: 1003 GEGEEEGEGEGEEEEEG-EVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREE 1061

Query: 227  EHANSKQEEDNTQSDDILEESDQPTQVSKMQ 257
            E     + ++  + ++  ++ ++  +VSK++
Sbjct: 1062 EEEEEGKYQETGEEENERQDGEEYKKVSKIK 1092


>gi|93141003 testican 3 isoform 1 [Homo sapiens]
          Length = 433

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 68/263 (25%), Positives = 95/263 (36%), Gaps = 79/263 (30%)

Query: 429 AVDSCMSFQCKRGHICKADQQGKPHCVCQDPVT-----------------------CPPT 465
           A D C+  +C R  +C A       C+    +T                       CP  
Sbjct: 83  AKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHRMKEAGVDHRQWRGPILSTCKQCPVV 142

Query: 466 KPLDQVCGTDNQTYASSCHLFATKCRLEGTKKGHQLQLDYFGAC---KSIPT-------- 514
            P   VCG+D  TY+  C L    C L     G Q+ +   G C      PT        
Sbjct: 143 YP-SPVCGSDGHTYSFQCKLEYQACVL-----GKQISVKCEGHCPCPSDKPTSTSRNVKR 196

Query: 515 -CTDFEVIQFPLRMRDWLKNILMQLYEANSEHAGYLNEKQRNKVKKIYLDEKRLLAGDHP 573
            C+D E  +   R+RDW K     L+E+ S+     N+K +                   
Sbjct: 197 ACSDLEFREVANRLRDWFK----ALHESGSQ-----NKKTKT------------------ 229

Query: 574 IDLLLRDFKKNYHMYVYPV-----HWQFSELDQHPMDRVLTHSELAPLRASLVPMEHCIT 628
              LLR  +  +   + P+      W F+ LD +  D +L  SEL  +   L   E C  
Sbjct: 230 ---LLRPERSRFDTSILPICKDSLGWMFNRLDTN-YDLLLDQSELRSIY--LDKNEQCTK 283

Query: 629 RFFEECDPNKDKHITLKEWGHCF 651
            FF  CD  KD  I+  EW +CF
Sbjct: 284 AFFNSCDTYKDSLISNNEWCYCF 306


>gi|93141001 testican 3 isoform 2 [Homo sapiens]
          Length = 436

 Score = 68.2 bits (165), Expect = 2e-11
 Identities = 68/263 (25%), Positives = 95/263 (36%), Gaps = 79/263 (30%)

Query: 429 AVDSCMSFQCKRGHICKADQQGKPHCVCQDPVT-----------------------CPPT 465
           A D C+  +C R  +C A       C+    +T                       CP  
Sbjct: 86  AKDPCLKMKCSRHKVCIAQDSQTAVCISHRRLTHRMKEAGVDHRQWRGPILSTCKQCPVV 145

Query: 466 KPLDQVCGTDNQTYASSCHLFATKCRLEGTKKGHQLQLDYFGAC---KSIPT-------- 514
            P   VCG+D  TY+  C L    C L     G Q+ +   G C      PT        
Sbjct: 146 YP-SPVCGSDGHTYSFQCKLEYQACVL-----GKQISVKCEGHCPCPSDKPTSTSRNVKR 199

Query: 515 -CTDFEVIQFPLRMRDWLKNILMQLYEANSEHAGYLNEKQRNKVKKIYLDEKRLLAGDHP 573
            C+D E  +   R+RDW K     L+E+ S+     N+K +                   
Sbjct: 200 ACSDLEFREVANRLRDWFK----ALHESGSQ-----NKKTKT------------------ 232

Query: 574 IDLLLRDFKKNYHMYVYPV-----HWQFSELDQHPMDRVLTHSELAPLRASLVPMEHCIT 628
              LLR  +  +   + P+      W F+ LD +  D +L  SEL  +   L   E C  
Sbjct: 233 ---LLRPERSRFDTSILPICKDSLGWMFNRLDTN-YDLLLDQSELRSIY--LDKNEQCTK 286

Query: 629 RFFEECDPNKDKHITLKEWGHCF 651
            FF  CD  KD  I+  EW +CF
Sbjct: 287 AFFNSCDTYKDSLISNNEWCYCF 309


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 67.0 bits (162), Expect = 5e-11
 Identities = 87/393 (22%), Positives = 162/393 (41%), Gaps = 27/393 (6%)

Query: 30   PTAETVA-PDNTAI--PSLRAEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAE 86
            P AE  A P++  +  P    +A+E E E    +ED    +AE  +  +S++    ++  
Sbjct: 1838 PEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEW 1897

Query: 87   QGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVS 146
            + +  S+     + E      + ++E   TEG  + + + +E QE   +E     A G +
Sbjct: 1898 EVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQE---AEEAAQEAEGQT 1954

Query: 147  SFTDSNQQESITKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEK 206
               +S   ES    EE Q +  +    ++   ++ ++G     +++ +   + GE +E +
Sbjct: 1955 Q-PESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAE 2013

Query: 207  EPGEVGTHNDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGN- 265
            E  E    +D  E + +   E A   + E      D   ESD        +E +  +G  
Sbjct: 2014 E--EAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEV 2071

Query: 266  QEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEPT 325
            QE E  ++ E E+ +A       QE E ++Q    G+EA     E ++    EA    P 
Sbjct: 2072 QEAEGEAHPESEDVDA-------QEAEGEAQPESEGVEAPEAEGEAQKAEGIEA----PE 2120

Query: 326  DDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIEE 385
             +G   P + G++    +      ++G     ++    P    +EA+ A+  A     + 
Sbjct: 2121 TEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIEAQEAEEEA-----QP 2175

Query: 386  QREKVHENENIGTTEP-GEHQEAKKAENSSNEE 417
            + E V   E  G  +P  E  EA +AE  +  E
Sbjct: 2176 ELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPE 2208



 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 88/422 (20%), Positives = 159/422 (37%), Gaps = 69/422 (16%)

Query: 51   ENEKETAVSTEDDSHHKAEKS--SVLKSKEESHEQSAEQGKSSSQELGLKD--------- 99
            E E +      +   H +E S  S L   E+  E  +E+G++  Q  G +D         
Sbjct: 1762 EAEGDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAG 1821

Query: 100  --QEDSDGHLSVNLEYAPTEGTL----------DIKEDMSEPQEKKLSENTDFLAPGVSS 147
              Q+      +  +E    EG            + + D  E + +   E+ D  AP    
Sbjct: 1822 GDQDPGQSDGAEGIEAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEG 1881

Query: 148  FTDSNQQESITKREENQEQPRNY------SHHQLNRSSKHSQGLRDQGNQEQDPNISNGE 201
                  ++  T   E + QP +       +  +    ++  + L  +G  E +   +  +
Sbjct: 1882 EAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVEALETEGEDEPESEGAEAQ 1941

Query: 202  EEEEK-EPGEVGTHNDNQERKTELPREHANSKQE------------EDNTQSDDILEESD 248
            E EE  +  E  T  +++  +++   E A  + E            E   ++    E+ +
Sbjct: 1942 EAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVE 2001

Query: 249  QPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKTGLEAISNH 308
             P    +MQE E +   +     +  + E E A  V    Q+TE  +Q    G+EA    
Sbjct: 2002 APEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAE 2061

Query: 309  KETEEKTVSEALLMEPTDDGNTTPRNHGVD---DDGDDDGDDGGTDGPRHSASDDYFIPS 365
            +E +E   +E  + E   +G   P +  VD    +G+   +  G + P            
Sbjct: 2062 EEAQE---AEGEVQEA--EGEAHPESEDVDAQEAEGEAQPESEGVEAP------------ 2104

Query: 366  QAFLEAERAQSIAYHLKIEEQREKVHENENIGTTE-PGEHQ---EAKKAENSSNEEETSS 421
            +A  EA++A+ I      E + E   E+E I   E  GE Q   E  +A+++  E +  S
Sbjct: 2105 EAEGEAQKAEGIE---APETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPES 2161

Query: 422  EG 423
            EG
Sbjct: 2162 EG 2163



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 80/365 (21%), Positives = 134/365 (36%), Gaps = 69/365 (18%)

Query: 116  TEGTLDIKEDMSEPQEKKLSENTDF----LAPGVSSFTDSNQQESITKREENQEQPRNYS 171
            T G +    D+ +  ++K  E+TD     +APG  + TD     ++   E          
Sbjct: 1679 TRGPIKEAFDLQQILQRKRGEHTDGEAAEVAPG-KTHTDPTSTRTVQGAEGGLGPG---- 1733

Query: 172  HHQLNRSSKHSQGLRDQG----NQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPRE 227
               L++     +G   +G    N+++DP +   E +   +  E  THN      +EL   
Sbjct: 1734 ---LSQGPGVDEGEDGEGSQRLNRDKDPKLGEAEGDAMAQEREGKTHNSETSAGSELGEA 1790

Query: 228  H-------------ANSKQEEDNTQSD------------DILEESDQPTQVSKMQED--- 259
                                EDN Q +            D  E  + P    + Q +   
Sbjct: 1791 EQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQDPGQSDGAEGIEAPEAEGEAQPESEG 1850

Query: 260  ----EFDQGNQEQEDNSNAEMEEENASNVNKHIQ---------ETEWQSQEGKTGLEAIS 306
                E +   QE E  +  E E+  A       Q         E EW+ Q    G EA  
Sbjct: 1851 VEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPE 1910

Query: 307  NHKETEEKTVS-EALLMEPTDDGNTTPRNHGVDDDGDDDG--DDGGTDGPRHSASDDYFI 363
              KE + +T S EAL  E  D+    P + G +    ++   +  G   P     +    
Sbjct: 1911 AEKEAQPETESVEALETEGEDE----PESEGAEAQEAEEAAQEAEGQTQPESEVIESQEA 1966

Query: 364  PSQAFLEAERAQSIAYHLKIEE-QREKVHENENIGTTE-PGEHQEAK---KAENSSNEEE 418
              +A  E+E  +++   ++ +E + E   E+E++   E  GE QEA+   + E+   E +
Sbjct: 1967 EEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEAQPESDGVEAQ 2026

Query: 419  TSSEG 423
              SEG
Sbjct: 2027 PKSEG 2031



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 55/232 (23%), Positives = 91/232 (39%), Gaps = 43/232 (18%)

Query: 222  TELPREHANSKQEEDNTQSDDILEESDQ---PTQVSKM------QEDEFDQGNQEQEDNS 272
            TELP + +N + +    +S   LE   Q   PT ++         EDE ++ ++EQ  +S
Sbjct: 1228 TELPLKTSNQRPDSRTYESPGDLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASS 1287

Query: 273  NAE------------MEEENASNVNKHIQETEWQSQEGKT--GLE----AISNHKET--E 312
            N E            +EE       + +QE   Q +E KT  GL+     +   KET  E
Sbjct: 1288 NLEQLAENTVQEEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGE 1347

Query: 313  EKTVSEALLMEPTDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAE 372
             +   EA L E  + G    +  GV  +   +G +GG  G             +A  E  
Sbjct: 1348 GQQEEEAQLEEIEETGGEGLQEEGVQLEEVKEGPEGGLQG-------------EALEEGL 1394

Query: 373  RAQSIAYHLKIEEQR-EKVHENENIGTTEPGEHQEAKKAENSSNEEETSSEG 423
            + + +     +  Q   +    +  G+ E    QE +    S++ E   +EG
Sbjct: 1395 KEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEG 1446



 Score = 36.2 bits (82), Expect = 0.100
 Identities = 57/265 (21%), Positives = 107/265 (40%), Gaps = 35/265 (13%)

Query: 117  EGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQLN 176
            E   D +E  +    ++L+ENT      V       + +  T+ E  QE+          
Sbjct: 1275 EAERDSEEQRASSNLEQLAENT------VQEEVQLEETKEGTEGEGLQEEAVQLEE---- 1324

Query: 177  RSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPREHANSKQEED 236
              +K  +GL+++G Q ++   + GE ++E            +E + E   E      +E+
Sbjct: 1325 --TKTEEGLQEEGVQLEETKETEGEGQQE------------EEAQLEEIEETGGEGLQEE 1370

Query: 237  NTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQETEWQSQ 296
              Q +++ E  +   Q   ++E   ++G  E+      E+ E ++ +     ++   Q +
Sbjct: 1371 GVQLEEVKEGPEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKGSQEDDPVQEE 1430

Query: 297  E-GKTGLEAISNHKE-TEEKTVSEALLMEPTDDGNTTPRNHGVDDDGDDDGDDGGT-DGP 353
            E G+    A     E TEE T   + L E   D + + R  G   +   +   G T  G 
Sbjct: 1431 EAGRASASAEPCPAEGTEEPTEPPSHLSE--TDPSASERQSGSQLEPGLEKPPGATMMGQ 1488

Query: 354  RHSASDDYFIPSQAFLEAERAQSIA 378
             H+ +     P+Q    AER+ S+A
Sbjct: 1489 EHTQAQ----PTQG--AAERSSSVA 1507



 Score = 31.2 bits (69), Expect = 3.2
 Identities = 41/155 (26%), Positives = 67/155 (43%), Gaps = 33/155 (21%)

Query: 45   LRAEA-EENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDS 103
            L+ EA EE  KE  +  E   H            +E  E S+  GK S ++  +  QE+ 
Sbjct: 1385 LQGEALEEGLKEEGLPEEGSVHG-----------QELSEASSPDGKGSQEDDPV--QEEE 1431

Query: 104  DGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREEN 163
             G  S + E  P EGT    E+ +EP    LSE TD           +++++S ++ E  
Sbjct: 1432 AGRASASAEPCPAEGT----EEPTEP-PSHLSE-TD---------PSASERQSGSQLEPG 1476

Query: 164  QEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNIS 198
             E+P   +        +H+Q    QG  E+  +++
Sbjct: 1477 LEKPPGAT----MMGQEHTQAQPTQGAAERSSSVA 1507


>gi|20270337 Leo1, Paf1/RNA polymerase II complex component, homolog
           [Homo sapiens]
          Length = 666

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 77/410 (18%), Positives = 153/410 (37%), Gaps = 40/410 (9%)

Query: 47  AEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGH 106
           +EAE  + ++   ++ D  + A  S+   S+ +  E+  + G+ S++EL   D ED    
Sbjct: 14  SEAERKDSDSGSDSDSDQENAASGSNASGSESDQDERG-DSGQPSNKELFGDDSEDEGAS 72

Query: 107 LSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQ 166
                 ++ ++   +  ++ SE  E+   E+ D      S     +  E+    E+   +
Sbjct: 73  -----HHSGSDNHSERSDNRSEASERSDHEDND-----PSDVDQHSGSEAPNDDEDEGHR 122

Query: 167 PRNYSHHQLNRSSK--HSQ----GLRDQGNQEQDPNISNGEEEEEKEPGEVGT------- 213
               SHH     S+  HS     G  D+ +Q  D  I N ++EE  +  +          
Sbjct: 123 SDGGSHHSEAEGSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSDDD 182

Query: 214 ---HNDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQED 270
               N + E + +L  +      EE+   SDD    +       +  +DE      ++E 
Sbjct: 183 EKMQNTDDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDEKQNSDDEEQPQLSDEEK 242

Query: 271 NSNAEMEEENASN-VNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGN 329
             N++ E   AS+  ++H  + E Q  + ++   + S  +    K  +        D   
Sbjct: 243 MQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLRMKRKNAIASDSEADSDT 302

Query: 330 TTPRNHG--VDDDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIEEQR 387
             P+++   +D  G  D    G+DG     +    +      + ++ +      +IE + 
Sbjct: 303 EVPKDNSGTMDLFGGADDISSGSDGEDKPPTPGQPVDENGLPQDQQEEEPIPETRIEVEI 362

Query: 388 EKVHEN----------ENIGTTEPGEHQEAKKAENSSNEEETSSEGNMRV 427
            KV+ +           N  + EP         +   +EE    EG  R+
Sbjct: 363 PKVNTDLGNDLYFVKLPNFLSVEPRPFDPQYYEDEFEDEEMLDEEGRTRL 412



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 55/270 (20%), Positives = 107/270 (39%), Gaps = 37/270 (13%)

Query: 25  SDHSKPTAETVAPDNTAIPSLRAEAEENEKET--------AVSTEDDSHHKAEKSSVLKS 76
           S HS     +   DN +  S R++ E+N+           A + ++D  H+++  S    
Sbjct: 72  SHHSGSDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSEAPNDDEDEGHRSDGGS---- 127

Query: 77  KEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSE 136
              S  + +E+  S  ++ G +D+ D                  D K   S+ +E+    
Sbjct: 128 -HHSEAEGSEKAHSDDEKWGREDKSDQSD---------------DEKIQNSDDEERAQGS 171

Query: 137 NTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSK-HSQGLRDQGNQEQDP 195
           + D L    +S  D   Q +    +E + Q  +    QL+   K +S   R   +   D 
Sbjct: 172 DEDKLQ---NSDDDEKMQNT---DDEERPQLSDDERQQLSEEEKANSDDERPVASDNDDE 225

Query: 196 NISNGEEEEEKEPGEVGTHNDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSK 255
             ++ +EE+ +   E    N + ER      EH +S  EE+     +    SD   +V +
Sbjct: 226 KQNSDDEEQPQLSDEEKMQNSDDERPQASDEEHRHSDDEEEQDHKSESARGSDSEDEVLR 285

Query: 256 MQEDEFDQGNQEQEDNSNAEMEEENASNVN 285
           M+       + E +  S+ E+ ++N+  ++
Sbjct: 286 MKRKNAIASDSEAD--SDTEVPKDNSGTMD 313



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 32/167 (19%), Positives = 72/167 (43%), Gaps = 6/167 (3%)

Query: 266 QEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSE-ALLMEP 324
           ++ +  S+++ ++ENA++ +        Q + G +G    SN +   + +  E A     
Sbjct: 19  KDSDSGSDSDSDQENAASGSNASGSESDQDERGDSGQP--SNKELFGDDSEDEGASHHSG 76

Query: 325 TDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIE 384
           +D+ +    N     +  D  D+  +D  +HS S+    P+    E  R+   ++H + E
Sbjct: 77  SDNHSERSDNRSEASERSDHEDNDPSDVDQHSGSE---APNDDEDEGHRSDGGSHHSEAE 133

Query: 385 EQREKVHENENIGTTEPGEHQEAKKAENSSNEEETSSEGNMRVHAVD 431
              +   ++E  G  +  +  + +K +NS +EE        ++   D
Sbjct: 134 GSEKAHSDDEKWGREDKSDQSDDEKIQNSDDEERAQGSDEDKLQNSD 180


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 65.1 bits (157), Expect = 2e-10
 Identities = 54/401 (13%), Positives = 148/401 (36%), Gaps = 18/401 (4%)

Query: 25   SDHSKPTAETVAPD-NTAIPSLRAEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQ 83
            SD S   +++ + D N++  S  +++ ++   +  S   DS   ++ SS   S   S   
Sbjct: 631  SDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSS 690

Query: 84   SAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAP 143
             +    +SS+     D  DSD           ++ +     + S+      S+++D    
Sbjct: 691  DSSDSSNSSESSDSSDSSDSDS----------SDSSDSSNSNSSDSDSSNSSDSSDS--- 737

Query: 144  GVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEE 203
              S+ +DS+     +   ++ +   + +    + SS  S       + + + + ++ +  
Sbjct: 738  --SNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSS 795

Query: 204  EEKEPGEVGTHNDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQ 263
            +     +    +D+ +       + +NS    +++ S D    SD           + D 
Sbjct: 796  DSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDS 855

Query: 264  GNQEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLME 323
             N+    NS+   +  ++SN +     ++       +     SN  +++    S +   +
Sbjct: 856  SNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDSDSSDSSNS--SD 913

Query: 324  PTDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKI 383
             +D  N++  +   +   + +  D         +SD       +        S +     
Sbjct: 914  SSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNS 973

Query: 384  EEQREKVHENENIGTTEPGEHQEAKKAENSSNEEETSSEGN 424
             +  +  + +++  +++  +  ++  + NSS+  ++S   +
Sbjct: 974  SDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSD 1014



 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 65/403 (16%), Positives = 141/403 (34%), Gaps = 17/403 (4%)

Query: 25  SDHSKPTAETVAPDNTAIPSLRAEAEENEKETAVS-TEDDSHHKAEKSSVLKSKEESHEQ 83
           SD  K  +++   D++   +    ++ ++ +++ S +  DS      SS     + S   
Sbjct: 540 SDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSS 599

Query: 84  SAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAP 143
           ++     SS      D  DS    S + +        D K D S+      S+N+D    
Sbjct: 600 NSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDNSD---- 655

Query: 144 GVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEE 203
              S   SN   S    + +     + S    N S           ++  D + S+  + 
Sbjct: 656 ---SSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDS 712

Query: 204 EEKEPGEVGTHNDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQ 263
            +         +D+    +    + +NS    D++ S +  + SD  +  S    D  D 
Sbjct: 713 SDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSD--SSDSSNSSDSSDS 770

Query: 264 GNQEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEAL-LM 322
            +     +S+   +  ++SN +     +        +     S+  +++    S++    
Sbjct: 771 SDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSS 830

Query: 323 EPTDDGNTTPRNHGVD-DDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHL 381
           + +D  N++  +   D  DG D      +D    S S D    S +   ++ + S     
Sbjct: 831 DSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDS----- 885

Query: 382 KIEEQREKVHENENIGTTEPGEHQEAKKAENSSNEEETSSEGN 424
                     ++ N   ++  +   +  + +SSN  ++S   N
Sbjct: 886 NESSNSSDSSDSSNSSDSDSSDSSNSSDSSDSSNSSDSSESSN 928



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 57/339 (16%), Positives = 126/339 (37%), Gaps = 28/339 (8%)

Query: 25   SDHSKPTAETVAPDNTAIPSLRAEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQS 84
            S  S  ++++    N++  S  +++ ++   +  S   DS + ++ S    S + S    
Sbjct: 988  SSDSSDSSDSSDSSNSSDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSD 1047

Query: 85   AEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPG 144
            +     SS      D  DS    S + + + +  + D  E          S+++D     
Sbjct: 1048 SSDSSDSSNSSDSSDSSDS----SDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDS---- 1099

Query: 145  VSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEE 204
             S  +DS+     +   ++ +   +      + SS  S       + +   +  + +  +
Sbjct: 1100 -SDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSD 1158

Query: 205  EKEPGEVGTHNDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQG 264
              +  +    +D+ +       + +NS    D++ S D  + SD     S    D  D  
Sbjct: 1159 SSDSSDSSDSSDSSDSS-----DSSNSSDSSDSSDSSDSSDSSDSSD--SSDSSDSSDSS 1211

Query: 265  NQEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVS---EALL 321
            +     +S+   +  ++S+ N+    ++       +     S+  ++ + T     E+  
Sbjct: 1212 DSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDS 1271

Query: 322  MEPTDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDD 360
               + +GN    N+G D D D +G D       HS SDD
Sbjct: 1272 QSKSGNGN----NNGSDSDSDSEGSDSN-----HSTSDD 1301



 Score = 59.7 bits (143), Expect = 8e-09
 Identities = 79/430 (18%), Positives = 155/430 (36%), Gaps = 45/430 (10%)

Query: 31  TAETVAPDNTAIPSLRAEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKS 90
           T E    DN+        A+E+E E +   ED+             K+ S+    ++G+ 
Sbjct: 233 TGEDAGLDNSDGSPSGNGADEDEDEGSGDDEDE--------EAGNGKDSSNNSKGQEGQD 284

Query: 91  SSQELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTD 150
             +E    D + S G  S + EY   EG  D   ++   +  K  EN    + G+    D
Sbjct: 285 HGKE---DDHDSSIGQNSDSKEYYDPEGKEDPHNEVDGDKTSKSEEN----SAGIPE--D 335

Query: 151 SNQQESITKREENQEQPRNYSHHQLNRSSKHSQG-LRDQGNQEQDPNISN-------GEE 202
           +  Q     ++ N  + +   +     S  H+ G  +D+G + + P+  N       G+ 
Sbjct: 336 NGSQRIEDTQKLNHRESKRVENRITKESETHAVGKSQDKGIEIKGPSSGNRNITKEVGKG 395

Query: 203 EEEKE----------PGEVGTHNDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQ 252
            E KE           G V T  +    +    +    +K    NT SD   +  D    
Sbjct: 396 NEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSNTGSDSNSDGYDSYDF 455

Query: 253 VSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKTGLEAISNHKETE 312
             K  + +    + E   N +A  E +N S+          +S++   G ++     +  
Sbjct: 456 DDKSMQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDS 515

Query: 313 EKTV------SEALLMEPTDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDDYFIPSQ 366
           + T       S        DD + +    G  D  D D  D         +SD     S 
Sbjct: 516 DSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSN 575

Query: 367 AFLEAERAQSIAYHLKIEEQREKVHENENIGTTEPGEHQEAKKA----ENSSNEEETSSE 422
           +  +++ + S +      +  +  + +++  +++  +  ++  +     +SS  E  SS+
Sbjct: 576 SSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSD 635

Query: 423 GNMRVHAVDS 432
            + +  + DS
Sbjct: 636 SDSKSDSSDS 645



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 65/387 (16%), Positives = 146/387 (37%), Gaps = 44/387 (11%)

Query: 48  EAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHL 107
           +  ++E+ +A   ED+   + E +  L  +E    ++    +S +  +G    +  D  +
Sbjct: 321 KTSKSEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKESETHAVG----KSQDKGI 376

Query: 108 SVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQP 167
            +     P+ G  +I +++ +  E K  +    +  G  +     +  +I    +  E P
Sbjct: 377 EIK---GPSSGNRNITKEVGKGNEGKEDKGQHGMILGKGNVKTQGEVVNIEGPGQKSE-P 432

Query: 168 RNYSHHQLNRSSKHSQG-----LRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKT 222
            N   H    S  +S G       D+  Q  DPN S      ++  G    ++++    +
Sbjct: 433 GNKVGHSNTGSDSNSDGYDSYDFDDKSMQGDDPNSS------DESNGNDDANSESDNNSS 486

Query: 223 ELPREHANSKQEEDNTQSDDI--LEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEEN 280
                  NS + +DN    D    E+ D  +       D    GN   +DN  ++  +  
Sbjct: 487 SRGDASYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGK 546

Query: 281 ASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGVDDD 340
           + + +    ++              SN  ++ + + S+      + D N++  +   D D
Sbjct: 547 SDSSDSDSSDS--------------SNSSDSSDSSDSD------SSDSNSSSDSDSSDSD 586

Query: 341 GDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIE---EQREKVHENENIG 397
             D  D   +D    S S D    S +   ++ + S +   K E      +   ++ +  
Sbjct: 587 SSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSN 646

Query: 398 TTEPGEHQEAKKAENSSNEEETSSEGN 424
           +++  ++ ++  + NSSN  ++S   +
Sbjct: 647 SSDSSDNSDSSDSSNSSNSSDSSDSSD 673



 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 65/412 (15%), Positives = 147/412 (35%), Gaps = 26/412 (6%)

Query: 26  DHSKPTAETVAPDNTAIPSLRAEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSA 85
           D S  T++T   D+    +     + ++ ++     D S   +  SS      +S +  +
Sbjct: 513 DDSDSTSDTNNSDSNGNGN-NGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDS 571

Query: 86  EQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGV 145
               SSS      D  DSD   S + + + +  + D  +          S+++D      
Sbjct: 572 SDSNSSSDS----DSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSD------ 621

Query: 146 SSFTDSNQQESITKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEE 205
            S +DS++ ES +   +++           + +S  S    D  +     N S+  +  +
Sbjct: 622 -SKSDSSKSESDSSDSDSKSD-------SSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSD 673

Query: 206 KEPGEVGTHNDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGN 265
                  + + N    ++   + +NS +  D++ S D  + SD     +    D     +
Sbjct: 674 SSDSSSSSDSSNSSDSSD-SSDSSNSSESSDSSDSSD-SDSSDSSDSSNSNSSDSDSSNS 731

Query: 266 QEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSE----ALL 321
            +  D+SN+    +++ + N         S       ++  +   ++    S+    +  
Sbjct: 732 SDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNS 791

Query: 322 MEPTDDGNTTPRNHGVD-DDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYH 380
            + +D  N++  ++  D  D  D  D   ++    S S D    S +   ++ + S    
Sbjct: 792 SDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGS 851

Query: 381 LKIEEQREKVHENENIGTTEPGEHQEAKKAENSSNEEETSSEGNMRVHAVDS 432
                 R     + +   +    +       + SNE   SS+ +   ++ DS
Sbjct: 852 DSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESSNSSDSSDSSNSSDS 903



 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 57/401 (14%), Positives = 136/401 (33%), Gaps = 10/401 (2%)

Query: 25   SDHSKPTAETVAPDNTAIPSLRAEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQS 84
            SD S  +  + +  + +  S  +++ ++   +  S   DS + ++ S    S   S    
Sbjct: 710  SDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSD 769

Query: 85   AEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPG 144
            +     SS      D  DS      +     ++ +       S       S N+   +  
Sbjct: 770  SSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNS 829

Query: 145  VSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEE 204
              S   SN  +S    + +     + S+   + +S  S    D  N     + S+  E  
Sbjct: 830  SDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNESS 889

Query: 205  EKEPGEVGTHNDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQV-SKMQEDEFDQ 263
                    +++ + +       + +NS    D++ S D  E S+      S    +  D 
Sbjct: 890  NSSDSSDSSNSSDSDSS-----DSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDS 944

Query: 264  GNQEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLME 323
             +     NS+      ++SN +         S +     ++  +   ++    S++    
Sbjct: 945  SDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSS 1004

Query: 324  PTDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKI 383
             + D + +  +    D  +       +D    S S D    S +   ++ + S       
Sbjct: 1005 DSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNS----SDS 1060

Query: 384  EEQREKVHENENIGTTEPGEHQEAKKAENSSNEEETSSEGN 424
             +  +    +++  +++  +  E+  + +SSN  ++S   +
Sbjct: 1061 SDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSD 1101



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 58/363 (15%), Positives = 134/363 (36%), Gaps = 26/363 (7%)

Query: 62  DDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTLD 121
           DD +   E +    +  ES   S+ +G +S      KD  + +G  S   E   ++ T D
Sbjct: 463 DDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKD--NGNGSDSKGAEDDDSDSTSD 520

Query: 122 IKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSKH 181
                        + N+D    G +   D+++ +S   + ++ +   + S +  + SS  
Sbjct: 521 -------------TNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSD-SSDS 566

Query: 182 SQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPREHANSKQEEDNTQSD 241
           S       N   D + S+ +  +  +     + N +    +    + ++S    D+ +SD
Sbjct: 567 SDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDS-KSD 625

Query: 242 DILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKTG 301
               ESD     SK   D  D  + +  DNS++     ++++ +         S      
Sbjct: 626 SSKSESDSSDSDSK--SDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDS 683

Query: 302 LEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDDY 361
             +  +   ++    SE+     + D +++  +   + +  D      +D    S S D 
Sbjct: 684 SNSSDSSDSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDS 743

Query: 362 FIPSQAFLEAERAQSIAYHLKIEEQREKVHENENIGTTEPGEHQEAKKAENSSNEEETSS 421
              S +   ++ + S        +       +++  +++  +   +  + +SSN  ++S 
Sbjct: 744 SDSSDSSNSSDSSDS-------SDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSD 796

Query: 422 EGN 424
             N
Sbjct: 797 SSN 799



 Score = 37.7 bits (86), Expect = 0.034
 Identities = 63/294 (21%), Positives = 117/294 (39%), Gaps = 29/294 (9%)

Query: 74  LKSKEESHEQSAEQGKSSS-QELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEK 132
           +  KEE+   +  QG+ S     G  ++ +++G+   N +     G     ED++  QE 
Sbjct: 124 IHGKEENITANGIQGQVSIIDNAGATNRSNTNGNTDKNTQNGDV-GDAGHNEDVAVVQED 182

Query: 133 KLSENTDFLAPGVSSFTDSNQQ--ESITKREENQEQ--PRNYSHHQLNRSSKHSQGL-RD 187
                      G ++ TD+  +  E+  + E N  +  P+  S     + ++ + G   D
Sbjct: 183 GPQ------VAGSNNSTDNEDEIIENSCRNEGNTSEITPQINSKRNGTKEAEVTPGTGED 236

Query: 188 QGNQEQDPNIS-NGEEEEEKEPGEVGTHNDNQERKTELPREHANSKQEE--DNTQSDDIL 244
            G    D + S NG +E+E E    G+ +D  E          NSK +E  D+ + DD  
Sbjct: 237 AGLDNSDGSPSGNGADEDEDE----GSGDDEDEEAGNGKDSSNNSKGQEGQDHGKEDDHD 292

Query: 245 EESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENAS-----NVNKHIQETE-WQSQEG 298
               Q +   +  + E  +    + D       EEN++     N ++ I++T+    +E 
Sbjct: 293 SSIGQNSDSKEYYDPEGKEDPHNEVDGDKTSKSEENSAGIPEDNGSQRIEDTQKLNHRES 352

Query: 299 KTGLEAISNHKETEEKTVSEALLME---PTDDGNTTPRNHGVDDDGDDDGDDGG 349
           K     I+   ET     S+   +E   P+       +  G  ++G +D    G
Sbjct: 353 KRVENRITKESETHAVGKSQDKGIEIKGPSSGNRNITKEVGKGNEGKEDKGQHG 406



 Score = 36.6 bits (83), Expect = 0.076
 Identities = 50/233 (21%), Positives = 93/233 (39%), Gaps = 33/233 (14%)

Query: 226 REHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEE---NAS 282
           R + N   ++ NTQ+ D+  ++     V+ +QED    G Q    N++ + E+E   N+ 
Sbjct: 151 RSNTNGNTDK-NTQNGDV-GDAGHNEDVAVVQED----GPQVAGSNNSTDNEDEIIENSC 204

Query: 283 NVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGVDDDGD 342
               +  E   Q    + G +       T E    +     P+ +G     + G  DD D
Sbjct: 205 RNEGNTSEITPQINSKRNGTKEAEVTPGTGEDAGLDNSDGSPSGNGADEDEDEGSGDDED 264

Query: 343 DDGDDG--------GTDGPRHSASDDY------FIPSQAFLEAERAQSIAYHL------K 382
           ++  +G        G +G  H   DD+         S+ + + E  +     +      K
Sbjct: 265 EEAGNGKDSSNNSKGQEGQDHGKEDDHDSSIGQNSDSKEYYDPEGKEDPHNEVDGDKTSK 324

Query: 383 IEEQREKVHE---NENIGTTEPGEHQEAKKAENS-SNEEETSSEGNMRVHAVD 431
            EE    + E   ++ I  T+   H+E+K+ EN  + E ET + G  +   ++
Sbjct: 325 SEENSAGIPEDNGSQRIEDTQKLNHRESKRVENRITKESETHAVGKSQDKGIE 377


>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
           [Homo sapiens]
          Length = 651

 Score = 63.9 bits (154), Expect = 4e-10
 Identities = 82/393 (20%), Positives = 167/393 (42%), Gaps = 30/393 (7%)

Query: 48  EAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHL 107
           E +   +  A  T   S H+ E+S   KS  E++ +S +  K+ S+    KD++DS    
Sbjct: 149 EEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPES-QNSKTVSKNCSQKDKKDSKNSK 207

Query: 108 SVNLEYAPTEGT----LDIKEDMSEPQEKKLSENT---DFLAPGVSSFTDSNQQESITKR 160
             N E+  T+      L   +  ++P  +  SEN+   DFL   V    D +       R
Sbjct: 208 KTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLML-VGQSDDESINFDAWLR 266

Query: 161 EENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQER 220
             +Q   +NYS      + K ++    + +  +  +  + +++ +K    V   +  ++ 
Sbjct: 267 NYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDV 326

Query: 221 KTE---LPREHANSKQEEDNTQSD-DILEESDQPTQVSKMQED-EFDQGNQEQEDNSNAE 275
           K +      E  +SK E  +T+ D   L++ D+     K  E  + + G+ +   N +  
Sbjct: 327 KKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRN 386

Query: 276 MEEENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGNTTPRN- 334
           +++ + ++  K   +    S + ++ LE+  + K+ E+K   ++     TD+  +   + 
Sbjct: 387 LKKASKNDDKKKDAKKITFSTDSESELESKESQKD-EKKDKKDS----KTDNKKSVKNDE 441

Query: 335 HGVDDDGDDDGDD--GGTD---GPRHSASDDYFIPSQAFLEAERAQSIAYHLKIEEQREK 389
              D D +  GD   G  D   G + S  DD    ++     + A+S      +E +++K
Sbjct: 442 ESTDADSEPKGDSKKGKKDEKKGKKDSKKDDKKKDAK-----KNAESTEMESDLELKKDK 496

Query: 390 VHENENIGTTEPGEHQEAKKAENSSNEEETSSE 422
            H  E  G+ +  +    K  E++  E + SS+
Sbjct: 497 KHSKEKKGSKKDIKKDARKDTESTDAEFDESSK 529



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 50/328 (15%), Positives = 137/328 (41%), Gaps = 33/328 (10%)

Query: 98  KDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLA-PGVSSFTDSNQQES 156
           K   D++   S + +    +   ++K+D  +   KK +E+TD  +        D+ + + 
Sbjct: 293 KKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKK 352

Query: 157 ITKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHND 216
             K+++ ++  + Y       +   S   +D  N  ++   ++  ++++K+  ++ T + 
Sbjct: 353 KLKKDDKKKDTKKYP----ESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKKI-TFST 407

Query: 217 NQERKTELPREHANSKQEEDNTQSDD--ILEESDQPTQVSKMQEDEFDQGNQEQEDNSNA 274
           + E + E      + K+++ ++++D+   ++  ++ T      + +  +G ++++     
Sbjct: 408 DSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPKGDSKKGKKDEKKGKKD 467

Query: 275 EMEEENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGNTTPRN 334
             +++   +  K+ + TE +S      LE   + K ++EK  S+  + +     +     
Sbjct: 468 SKKDDKKKDAKKNAESTEMESD-----LELKKDKKHSKEKKGSKKDIKK-----DARKDT 517

Query: 335 HGVDDDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIEEQREKVHENE 394
              D + D+    G     +   SD          E+E +      L     ++K+ E++
Sbjct: 518 ESTDAEFDESSKTGFKTSTKIKGSD---------TESEES------LYKPGAKKKIDESD 562

Query: 395 NIGTTEPGEHQEAKKAENSSNEEETSSE 422
                   E  E+K+    S+++ T +E
Sbjct: 563 GTSANSKMEGLESKRGFRMSSKKTTFNE 590


>gi|217330641 IWS1 homolog [Homo sapiens]
          Length = 819

 Score = 63.2 bits (152), Expect = 8e-10
 Identities = 95/453 (20%), Positives = 165/453 (36%), Gaps = 63/453 (13%)

Query: 45  LRAEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSD 104
           L   A ++E E     +D      E++    S  E+ + +     S S+E       DS+
Sbjct: 75  LNLNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSE 134

Query: 105 GHLSVNLEYAPTEGTLDIKEDMSEPQEKKL-------SENTDFLAPGVSSFTDSNQQESI 157
               +N   + +E     K   S+ + ++L       SE  D L P +S           
Sbjct: 135 NEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSESEEPPRHQ 194

Query: 158 TKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEE-------EKEPGE 210
               EN+E P+       +      Q    +  +      S+ E EE       + E  +
Sbjct: 195 ASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISDSESED 254

Query: 211 VGTHNDNQERKTELPREHANSKQEED---NTQSDDILEE-------------------SD 248
              H  +     ELP+   +  + ED   N  SD   EE                   SD
Sbjct: 255 PPRHQASDSENEELPKPRISDSESEDPPRNQASDSENEELPKPRVSDSESEGPQKGPASD 314

Query: 249 QPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENAS-NVNKHIQETEWQSQEG------KTG 301
             T+ +   + + +  +    +N   + E +N S + + H+   ++ S +       K  
Sbjct: 315 SETEDASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQK 374

Query: 302 LEAISNHKETEEKTVSE---ALLMEPTDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSAS 358
           +++  + KE EE+ V++   A+L +  D+   + +   V  D DD   D  +D    S  
Sbjct: 375 MDSDEDEKEGEEEKVAKRKAAVLSDSEDEEKASAKKSRVVSDADDSDSDAVSD---KSGK 431

Query: 359 DDYFIPSQAFLEAERAQSIAYHLKIEEQ------REKVHENENIGTTEPGEHQEAKKAE- 411
            +  I S +  EA +  S     K EE+       E  +E EN+     GE  + ++ E 
Sbjct: 432 REKTIASDSEEEAGKELS---DKKNEEKDLFGSDSESGNEEENLIADIFGESGDEEEEEF 488

Query: 412 ---NSSNEEETSSEGNMRVHAVDSCMSFQCKRG 441
              N  + EE   E  ++  A DS      KRG
Sbjct: 489 TGFNQEDLEEEKGETQVK-EAEDSDSDDNIKRG 520



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 62/287 (21%), Positives = 118/287 (41%), Gaps = 54/287 (18%)

Query: 183 QGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQ--ERKTELPREHANSKQEED---- 236
           Q  RD G+  +D      E+    + G V  H++N+  +R+  LP+ H  +  E D    
Sbjct: 20  QDERDSGSDGED---DVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLN 76

Query: 237 ----NTQSDDILEESDQPTQVSKMQE-----DEFDQGNQEQEDNSNAE------MEEENA 281
               +++S+++  + D  ++  +  E      E +  NQ   D+ + E       + EN 
Sbjct: 77  LNASDSESEELHRQKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENE 136

Query: 282 SNVNKHIQETEWQSQEGK-----TGLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHG 336
             +N H  ++E     GK     + +E +     ++ +T  +AL  + +D  +  P  H 
Sbjct: 137 ELLNGHASDSE-NEDVGKHPASDSEIEELQKSPASDSET-EDALKPQISDSESEEPPRHQ 194

Query: 337 VDDDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIEEQRE----KVHE 392
             D  +++        PR S S+   +P     ++E  +   +     E  E    ++ +
Sbjct: 195 ASDSENEE-----PPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPKPRISD 249

Query: 393 NENIGTTEPGEHQEAKKAENSSNEE-------ETSSEGNMRVHAVDS 432
           +E   + +P  HQ    A +S NEE       ++ SE   R  A DS
Sbjct: 250 SE---SEDPPRHQ----ASDSENEELPKPRISDSESEDPPRNQASDS 289


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 51/246 (20%), Positives = 105/246 (42%), Gaps = 22/246 (8%)

Query: 53  EKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNLE 112
           EKE  +   ++  H+ EK    + K +  E+  EQ K   QE  +  QE+         +
Sbjct: 341 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE---------K 391

Query: 113 YAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSH 172
               E  +  +E+M + QE+K+ E  + +           Q+E + ++EE   +      
Sbjct: 392 IREQEEKIREQEEMMQEQEEKMGEQEEKM---------WEQEEEMQEQEEKMRRQEEKIR 442

Query: 173 HQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEE--KEPGEVGTHNDNQERKTELPREHAN 230
            Q  +  +  + +R+Q    Q+     GE+E +  ++  ++    +   R+ E  RE   
Sbjct: 443 EQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEK 502

Query: 231 S--KQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHI 288
              +QEE   + +++++E ++     + +  E ++  QEQE+    + E+     V    
Sbjct: 503 KIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEVRLRQ 562

Query: 289 QETEWQ 294
           QE + Q
Sbjct: 563 QEEKMQ 568



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 64/298 (21%), Positives = 124/298 (41%), Gaps = 37/298 (12%)

Query: 45  LRAEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSD 104
           L+A+ EENE    ++ + +     ++  + + +E+  EQ   + K   QE  ++ QE+  
Sbjct: 269 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQ---EEKIREQEEKMRRQEEMM 325

Query: 105 GHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQ 164
                       E  +  +E+M   +E+K+ E  + +          ++QE I ++EE +
Sbjct: 326 WE---------KEEKMRRQEEMMWEKEEKIRELEEKM----------HEQEKIREQEEKR 366

Query: 165 EQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEE---EEEKEPGEVGTHNDNQERK 221
           ++       +  +  +     +++  +EQ+  I   EE   E+E++ GE       QE +
Sbjct: 367 QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEE 426

Query: 222 TELPREHANSKQEEDNTQSDDILEESDQ-PTQVSKMQEDEFDQGNQE----------QED 270
            +   E    ++E+   Q   I E+ ++   Q   MQE E   G QE          QE 
Sbjct: 427 MQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQ 486

Query: 271 NSNAEMEEENASNVNKHIQETEWQSQEGKTGL-EAISNHKETEEKTVSEALLMEPTDD 327
                 +EE      K I+E E + +E +  + E      E EEK   +   M+  ++
Sbjct: 487 EEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEE 544



 Score = 47.0 bits (110), Expect = 6e-05
 Identities = 53/273 (19%), Positives = 107/273 (39%), Gaps = 14/273 (5%)

Query: 51  ENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVN 110
           E+EK        +   K E++ +L  +++   ++   GK   Q +  K Q   + +   N
Sbjct: 222 ESEKSEIQLNVKELKRKLERAKLLLPQQQLQAEADHLGKEL-QSVSAKLQAQVEENELWN 280

Query: 111 LEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQ----QESITKREENQEQ 166
                 E  +  +E+  + +E+K+ E  + +           +    +E   +R+E    
Sbjct: 281 RLNQQQEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMW 340

Query: 167 PRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPR 226
            +     +L       + +R+Q  + Q+      +E+ +++  ++    +    + E  R
Sbjct: 341 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIR 400

Query: 227 EHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQ---EDNSNAEMEEENASN 283
           E     QE++    +   +E     Q  +MQE E     QE+   E       +EE    
Sbjct: 401 EQEEMMQEQEEKMGE---QEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIRE 457

Query: 284 VNKHIQETEWQ--SQEGKTGLEAISNHKETEEK 314
             + +QE E +   QEGK   E  +  +E EEK
Sbjct: 458 QEEMMQEQEEKMGEQEGKM-CEQEAKMQEQEEK 489



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 38/195 (19%), Positives = 79/195 (40%), Gaps = 23/195 (11%)

Query: 48  EAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHL 107
           E EE  +E     ++      E+   +  +EE  ++  E  K   QE  +++QE      
Sbjct: 394 EQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEE--KMRRQEEKIREQEK----- 446

Query: 108 SVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQP 167
               +    E  +  +E+M + QE+K+ E    +           Q+  + ++EE   + 
Sbjct: 447 ----KIREQEEKIREQEEMMQEQEEKMGEQEGKMC---------EQEAKMQEQEEKMRRQ 493

Query: 168 RNYSHHQLNRSSKHSQGLRDQGN--QEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELP 225
                 Q  +  +  + +R+Q    QEQ+  +   EE+  ++  ++    +   R+ E  
Sbjct: 494 EEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKM 553

Query: 226 RE-HANSKQEEDNTQ 239
           RE     +Q+E+  Q
Sbjct: 554 REQEVRLRQQEEKMQ 568


>gi|24415404 MDN1, midasin homolog [Homo sapiens]
          Length = 5596

 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 80/405 (19%), Positives = 146/405 (36%), Gaps = 78/405 (19%)

Query: 48   EAEENEKETAVSTED-------------------DSHHKAEKSSVLKSKEESHEQSAEQG 88
            + EE+E+E    TE+                   DS +  +  S    KEE  E  A+ G
Sbjct: 4783 DEEEDEEEEDNKTEETGPGMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADDG 4842

Query: 89   KSSSQELGLK-DQEDSDGH----LSVNLEYAPTEGTLDIKEDMS-EPQEKKLSENTDFLA 142
                 ++  + D+ D D +       N E  P    LD+ +D++ + ++K   E+TD   
Sbjct: 4843 GQGEDKINEQIDERDYDENEVDPYHGNQEKVPEPEALDLPDDLNLDSEDKNGGEDTD--- 4899

Query: 143  PGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEE 202
                     N++       E +E+P    H    R    +     Q  QE +   S  ++
Sbjct: 4900 ---------NEEGEEENPLEIKEKPEEAGHEAEERGETETDQNESQSPQEPEEGPSEDDK 4950

Query: 203  EEEKEPGEVGTHNDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFD 262
             E +E  + G  +D      + P EH+  +Q+         +EE D+       +    D
Sbjct: 4951 AEGEEEMDTGA-DDQDGDAAQHPEEHSEEQQQS--------VEEKDKEADEEGGENGPAD 5001

Query: 263  QGNQEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLM 322
            QG Q QE+      EE   S+  + + E   + +    G   + N + T+   ++ A   
Sbjct: 5002 QGFQPQEE------EEREDSDTEEQVPEALERKEHASCGQTGVENMQNTQAMELAGA--- 5052

Query: 323  EPTDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLK 382
                     P      + G ++   G  D  +    +  FI   A  +  R  + ++  K
Sbjct: 5053 --------APEK----EQGKEEHGSGAADANQAEGHESNFIAQLASQKHTRKNTQSFKRK 5100

Query: 383  ---------IEEQREKVHENENIGTTEPGEHQEAKKAENSSNEEE 418
                     + +  E+VH  + + T +   H E   A+    + E
Sbjct: 5101 PGQADNERSMGDHNERVH--KRLRTVDTDSHAEQGPAQQPQAQVE 5143



 Score = 53.5 bits (127), Expect = 6e-07
 Identities = 80/378 (21%), Positives = 136/378 (35%), Gaps = 57/378 (15%)

Query: 87   QGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVS 146
            +G    +  G+KD  D  G    N E          ++D  +P  K   +  D       
Sbjct: 4676 EGGGIGEGEGMKDVSDQIG----NEEQVEDTFQKGQEKDKEDPDSKSDIKGEDNAIEMSE 4731

Query: 147  SFTDSNQQESITKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEK 206
             F        + ++EE+ E+    S  +     KH   L  +   + D  +   ++EEE 
Sbjct: 4732 DFDGKMHDGELEEQEEDDEK----SDSEGGDLDKHMGDLNGEEADKLDERLWGDDDEEED 4787

Query: 207  EPGEVGTHNDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQ 266
            E  E    N  +E    +  E +    ++DN  S +  ++  Q  +  + +E E D G Q
Sbjct: 4788 EEEE---DNKTEETGPGMDEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADDGGQ 4844

Query: 267  EQEDNSNAEMEE----ENASNVNKHIQETEWQSQ------------EGKTGLEAISNH-- 308
              ED  N +++E    EN  +     QE   + +            E K G E   N   
Sbjct: 4845 -GEDKINEQIDERDYDENEVDPYHGNQEKVPEPEALDLPDDLNLDSEDKNGGEDTDNEEG 4903

Query: 309  --------KETEEKTVSEALLMEPTDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDD 360
                    KE  E+   EA     T+      ++    ++G  + D    +    + +DD
Sbjct: 4904 EEENPLEIKEKPEEAGHEAEERGETETDQNESQSPQEPEEGPSEDDKAEGEEEMDTGADD 4963

Query: 361  YFIPSQAFLEAERAQSIAYHLKIEEQREKVHENENIGTTEPGEH---------QEAKKAE 411
                     + + AQ    H   EEQ++ V E +     E GE+         QE ++ E
Sbjct: 4964 Q--------DGDAAQHPEEH--SEEQQQSVEEKDKEADEEGGENGPADQGFQPQEEEERE 5013

Query: 412  NSSNEEETSSEGNMRVHA 429
            +S  EE+       + HA
Sbjct: 5014 DSDTEEQVPEALERKEHA 5031



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 47/262 (17%), Positives = 101/262 (38%), Gaps = 24/262 (9%)

Query: 75   KSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNLE-YAPTEGTLDIKEDMSEPQEK- 132
            + KEE    +A+  ++   E     Q  S  H   N + +    G  D +  M +  E+ 
Sbjct: 5058 QGKEEHGSGAADANQAEGHESNFIAQLASQKHTRKNTQSFKRKPGQADNERSMGDHNERV 5117

Query: 133  -KLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQ 191
             K     D         TDS+ ++   ++ + Q +  +   H    S  +     D  ++
Sbjct: 5118 HKRLRTVD---------TDSHAEQGPAQQPQAQVEDADAFEHIKQGSDAYDAQTYDVASK 5168

Query: 192  EQDPNISN-GEEEEEKEPGEVGTHNDNQERKTELPREHANSKQEEDNTQSDDILEESDQP 250
            EQ  +  + G+++EE+E  +     + QE       E    ++ +  T +    +E +  
Sbjct: 5169 EQQQSAKDSGKDQEEEEIEDTLMDTEEQEEFKAADVEQLKPEEIKSGTTAPLGFDEMEVE 5228

Query: 251  TQVSKMQEDE---FDQGNQEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKTGLEAISN 307
             Q  K +ED+    D+ ++E E+       E      ++ + +T +Q          + +
Sbjct: 5229 IQTVKTEEDQDPRTDKAHKETENEKPERSRESTIHTAHQFLMDTIFQ--------PFLKD 5280

Query: 308  HKETEEKTVSEALLMEPTDDGN 329
              E  ++   +  + +P + GN
Sbjct: 5281 VNELRQELERQLEMWQPRESGN 5302


>gi|4504487 histidine rich calcium binding protein precursor [Homo
           sapiens]
          Length = 699

 Score = 60.5 bits (145), Expect = 5e-09
 Identities = 89/463 (19%), Positives = 165/463 (35%), Gaps = 89/463 (19%)

Query: 27  HSKPTAETVAPDNTAIPSLRAEAEENEKETAVSTEDDSHH------------KAEKSSVL 74
           H     E  A     +PS R+ + ++E E  V + +  HH              E     
Sbjct: 137 HGSEDTEDSAEHRHHLPSHRSHSHQDEDEDEVVSSEHHHHILRHGHRGHDGEDDEGEEEE 196

Query: 75  KSKEESHEQSAEQGKSSSQELGLKDQED---SDGHLSVNLEYAPTEGTLDIKEDMSEPQE 131
           + +EE  E S E G  + +  G   +ED   SDGH      + P+      +ED  +  +
Sbjct: 197 EEEEEEEEASTEYGHQAHRHRGHGSEEDEDVSDGHH----HHGPSHRHQGHEEDDDDDDD 252

Query: 132 KKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSKHS--------- 182
               ++ D ++         +Q   I + E+  +      HH  + S +H          
Sbjct: 253 DDDDDDDDDVSIEYRHQAHRHQGHGIEEDEDVSD-----GHHHRDPSHRHRSHEEDDNDD 307

Query: 183 ---------QGLRDQGNQEQDPNISNGE------------EEEEKEPGEVGTHN------ 215
                    Q  R Q +++++    +GE              +E+E  +V T        
Sbjct: 308 DDVSTEYGHQAHRHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQ 367

Query: 216 -------DNQERKTELPRE--HANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQ 266
                  D +E + E+  +  H  +  +    +SD   EE  Q    +++      +  +
Sbjct: 368 HVHHGLVDEEEEEEEITVQFGHYVASHQPRGHKSD---EEDFQDEYKTEVPHHHHHRVPR 424

Query: 267 EQEDNSNAEMEEENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALL----M 322
           E+++  +AE+  +  S+   H  E     Q G   ++ +S+H          + L     
Sbjct: 425 EEDEEVSAELGHQAPSHRQSHQDEETGHGQRG--SIKEMSHHPPGHTVVKDRSHLRKDDS 482

Query: 323 EPTDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLK 382
           E   +    P +H  DD+  + G+ G   G R    ++         + E    ++ + +
Sbjct: 483 EEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEE---------DEEEGHGLSLNQE 533

Query: 383 IEEQREKVHENENIGTTEPGEHQE--AKKAENSSNEEETSSEG 423
            EE+ +K  E E        E  E  A  + + S EEE   EG
Sbjct: 534 EEEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEG 576



 Score = 53.1 bits (126), Expect = 8e-07
 Identities = 66/319 (20%), Positives = 117/319 (36%), Gaps = 35/319 (10%)

Query: 46  RAEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQEL--GLKDQEDS 103
           R +    E+  AVS E   H    +    + +EE  + S E+     Q +  GL D+E+ 
Sbjct: 320 RHQDHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHHGLVDEEEE 379

Query: 104 DGHLSVNL-EYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREE 162
           +  ++V    Y  +      K D  + Q++  +E               +       REE
Sbjct: 380 EEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVP-------------HHHHHRVPREE 426

Query: 163 NQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKE-----PGEVGTHNDN 217
           ++E      H   +    H           QD    +G+    KE     PG     + +
Sbjct: 427 DEEVSAELGHQAPSHRQSH-----------QDEETGHGQRGSIKEMSHHPPGHTVVKDRS 475

Query: 218 QERKTELPREHANSKQEEDNTQSDDILEESDQPTQV-SKMQEDEFDQGNQEQEDNSNAEM 276
             RK +   E    +    + + D+  E+ ++ T   S+ QEDE D+  +    + N E 
Sbjct: 476 HLRKDDSEEEKEKEEDPGSHEEDDESSEQGEKGTHHGSRDQEDEEDE-EEGHGLSLNQEE 534

Query: 277 EEENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHG 336
           EEE      +  ++ E + +  + G     +H E EE+        EP       P +  
Sbjct: 535 EEEEDKEEEEEEEDEERREERAEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRR 594

Query: 337 VDDDGDDDGDDGGTD-GPR 354
            +  G    ++ G D GP+
Sbjct: 595 EEAGGASSEEESGEDTGPQ 613



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 67/306 (21%), Positives = 118/306 (38%), Gaps = 51/306 (16%)

Query: 26  DHSKPTAETVAPDNTA-IPSLRAEAEENEKETA-VSTE------DDSHHKAEKSSVLKSK 77
           DH K   E V+ ++   +P  R +   +E+E   VSTE         HH      ++  +
Sbjct: 323 DHRKEEVEAVSGEHHHHVPDHRHQGHRDEEEDEDVSTERWHQGPQHVHH-----GLVDEE 377

Query: 78  EESHEQSAEQGK--SSSQELGLK-DQED--------------------SDGHLSVNLEY- 113
           EE  E + + G   +S Q  G K D+ED                     D  +S  L + 
Sbjct: 378 EEEEEITVQFGHYVASHQPRGHKSDEEDFQDEYKTEVPHHHHHRVPREEDEEVSAELGHQ 437

Query: 114 APTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHH 173
           AP+       E+    Q   + E +    PG +   D +        EE +++    SH 
Sbjct: 438 APSHRQSHQDEETGHGQRGSIKEMSHH-PPGHTVVKDRSHLRKDDSEEEKEKEEDPGSHE 496

Query: 174 QLNRSSKHSQ-----GLRDQGNQEQDPNISNG-------EEEEEKEPGEVGTHNDNQERK 221
           + + SS+  +     G RDQ   E+D    +G       EEEE+KE  E     + +E +
Sbjct: 497 EDDESSEQGEKGTHHGSRDQ-EDEEDEEEGHGLSLNQEEEEEEDKEEEEEEEDEERREER 555

Query: 222 TELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENA 281
            E+    +    EE+  + + + E+  + T +    +   + G    E+ S  +   ++A
Sbjct: 556 AEVGAPLSPDHSEEEEEEEEGLEEDEPRFTIIPNPLDRREEAGGASSEEESGEDTGPQDA 615

Query: 282 SNVNKH 287
                +
Sbjct: 616 QEYGNY 621


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score = 59.7 bits (143), Expect = 8e-09
 Identities = 74/380 (19%), Positives = 156/380 (41%), Gaps = 56/380 (14%)

Query: 51  ENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQE-LGLKDQEDSDGHLSV 109
           E  +E      ++   +AE+ +  ++ ++  E + E+ + + QE L  K +E+S G ++ 
Sbjct: 5   ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64

Query: 110 NLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRN 169
            +E       ++ +  + + + K  + NT       ++F      E + +REE       
Sbjct: 65  QVE-------VNAQNSVPDEEAKTTTTNTQVEGDDEAAFL-----ERLARREER------ 106

Query: 170 YSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPREHA 229
                  R  +  + L  Q  +E DP I++          +    ND  E +T    E +
Sbjct: 107 -------RQKRLQEALERQ--KEFDPTITDASLSLPSRRMQ----NDTAENETTEKEEKS 153

Query: 230 NSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQ 289
            S+QE    +  + + +S Q       +E++ +   +E+E+    +      + V   ++
Sbjct: 154 ESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVE 213

Query: 290 ETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGVDDDGDDDGDDGG 349
           E   +SQE +T + ++ N + + E+   E    E  + G+    +H   ++ D +  +  
Sbjct: 214 EKTTESQE-ETVVMSLKNGQISSEEPKQE----EEREQGSDEISHHEKMEEEDKERAEA- 267

Query: 350 TDGPRHSASDDYFIPSQAFLEAERAQSI--AYHLKIEEQREKVHENENIGTTEPGEHQEA 407
                           +A LEAE  + I      KI ++R ++   E     E  E +EA
Sbjct: 268 ---------------ERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQE-RERREA 311

Query: 408 KKAENSSNEEETSSEGNMRV 427
           ++ E    EE+ ++E   R+
Sbjct: 312 EERERMREEEKRAAEERQRI 331



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 62/330 (18%), Positives = 134/330 (40%), Gaps = 28/330 (8%)

Query: 26  DHSKPTAETVAPDNTAIPSLR-----AEAEENEKETAVSTEDDSHHKAEKSSVLKSKEES 80
           +  K    T+   + ++PS R     AE E  EKE    +  + +   E  +V KS +++
Sbjct: 116 ERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKN 175

Query: 81  HEQSAEQGKSSSQELGLKDQED------SDGHLSVNLEYAPTEG-----TLDIKEDMSEP 129
             + AE+ K   +E   +++E        +  + V +E   TE       + +K      
Sbjct: 176 DWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISS 235

Query: 130 QEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSKHSQGLRDQG 189
           +E K  E  +    G    +   + E   K     E+ R  +  +    ++  + + D+ 
Sbjct: 236 EEPKQEEERE---QGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADER 292

Query: 190 NQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTE----LPREHANSKQEEDNTQSDD--I 243
            + +    +  +E E +E  E     + ++R  E    +  E   + +E    + ++   
Sbjct: 293 ARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRA 352

Query: 244 LEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENAS-NVNKH-IQETEWQSQEGKTG 301
            EE  +  +  K   +E  +   E+E+ +  E ++ N      KH +QET+ + ++ +  
Sbjct: 353 AEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQK 412

Query: 302 LEA-ISNHKETEEKTVSEALLMEPTDDGNT 330
           +E    N K+ +E  +  A+L +  ++  T
Sbjct: 413 IEGKWVNEKKAQEDKLQTAVLKKQGEEKGT 442



 Score = 38.1 bits (87), Expect = 0.026
 Identities = 53/277 (19%), Positives = 105/277 (37%), Gaps = 28/277 (10%)

Query: 46  RAEAEENEKETAVSTE-----DDSHHKAEKSSVLKSKEES-------HEQSAEQGKSSSQ 93
           RA AEE EK      +     ++  H  +++ +   K E        +E+ A++ K  + 
Sbjct: 372 RARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTA 431

Query: 94  ELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQ 153
            L  K  E+    +    E    +     KE++ + + KK  E  +     V SF D  +
Sbjct: 432 VLK-KQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKE----EVKSFMDRKK 486

Query: 154 QESITKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGT 213
             +  K +  +       H +   S    +   D    E  P +  G+  EE       T
Sbjct: 487 GFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGET 546

Query: 214 HNDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSN 273
            ++  E+  +        KQ+E   + +++ ++ ++     K+ E+E  +  QE+ D   
Sbjct: 547 ESEEFEKLKQ--------KQQEAALELEELKKKREERR---KVLEEEEQRRKQEEADRKL 595

Query: 274 AEMEEENASNVNKHIQETEWQSQEGKTGLEAISNHKE 310
            E EE+         +  E   +  K   + +S+ K+
Sbjct: 596 REEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKK 632


>gi|13540523 nucleosomal binding protein 1 [Homo sapiens]
          Length = 282

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 57/251 (22%), Positives = 112/251 (44%), Gaps = 31/251 (12%)

Query: 67  KAEKSSVLKSK----EESHEQSAEQGKSSSQELGLKD---QEDSDGHLSVNLEYAPTEGT 119
           +   S  +K+K    EE+ + SA+    + QE  +++   +   +G   +    A  +  
Sbjct: 38  RTSSSRKMKTKSDMMEENIDTSAQAVAETKQEAVVEEDYNENAKNGEAKITEAPASEKEI 97

Query: 120 LDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSS 179
           +++KE+  E   +K  E  + +A  V      N++E   + EE+Q + +     +  +  
Sbjct: 98  VEVKEENIEDATEKGGEKKEAVAAEVK-----NEEEDQKEDEEDQNEEKG----EAGKED 148

Query: 180 KHSQGLRDQGNQEQDPNISNGEEEEEKEP----------GEVGTHNDNQERKTELPREHA 229
           K  +G  D G ++++ N   GE+ +EKE           GE G      E++ E  +E  
Sbjct: 149 KDEKGEED-GKEDKNGN-EKGEDAKEKEDGKKGEDGKGNGEDGKEKGEDEKEEEDRKETG 206

Query: 230 NSKQEEDNTQSDDILEESD-QPTQVSKMQED--EFDQGNQEQEDNSNAEMEEENASNVNK 286
           + K+ ED  +  D  E  D +  +  K +ED  E + GN+E+      +++EE       
Sbjct: 207 DGKENEDGKEKGDKKEGKDVKVKEDEKEREDGKEDEGGNEEEAGKEKEDLKEEEEGKEED 266

Query: 287 HIQETEWQSQE 297
            I+E + + +E
Sbjct: 267 EIKEDDGKKEE 277



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 47/207 (22%), Positives = 94/207 (45%), Gaps = 39/207 (18%)

Query: 47  AEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKD-QEDSDG 105
           A  +  EK+ AV+ E  +  + +K    + +E+ +E+  E GK    E G +D +ED +G
Sbjct: 108 ATEKGGEKKEAVAAEVKNEEEDQK----EDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNG 163

Query: 106 HLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQE 165
           +              +  ED  E ++ K  E+      G  +  D  ++    K EE+++
Sbjct: 164 N--------------EKGEDAKEKEDGKKGED------GKGNGEDGKEKGEDEKEEEDRK 203

Query: 166 QPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPG---EVGTHNDNQERKT 222
           +  +          K ++  +++G++++  ++   E+E+E+E G   E G   +  + K 
Sbjct: 204 ETGD---------GKENEDGKEKGDKKEGKDVKVKEDEKEREDGKEDEGGNEEEAGKEKE 254

Query: 223 ELPREHANSKQEEDNTQSDDILEESDQ 249
           +L  E     +EED  + DD  +E  Q
Sbjct: 255 DLKEEEEG--KEEDEIKEDDGKKEEPQ 279



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 47/217 (21%), Positives = 95/217 (43%), Gaps = 43/217 (19%)

Query: 40  TAIPSLRAE-AEENEKETAVSTEDDSHHKAEKSSVLKSKEE--------SHEQSAEQGKS 90
           T  P+   E  E  E+    +TE     K   ++ +K++EE         +E+  E GK 
Sbjct: 88  TEAPASEKEIVEVKEENIEDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKE 147

Query: 91  SSQELGLKD-QEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFT 149
              E G +D +ED +G+              +  ED  E ++ K  E+      G  +  
Sbjct: 148 DKDEKGEEDGKEDKNGN--------------EKGEDAKEKEDGKKGED------GKGNGE 187

Query: 150 DSNQQESITKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPG 209
           D  ++    K EE++++             K ++  +++G++++  ++   E+E+E+E G
Sbjct: 188 DGKEKGEDEKEEEDRKE---------TGDGKENEDGKEKGDKKEGKDVKVKEDEKEREDG 238

Query: 210 EVGTHNDNQERKTELPREHANSKQEEDNTQSDDILEE 246
           +     D    + E  +E  + K+EE+  + D+I E+
Sbjct: 239 K----EDEGGNEEEAGKEKEDLKEEEEGKEEDEIKED 271



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 52/240 (21%), Positives = 94/240 (39%), Gaps = 51/240 (21%)

Query: 191 QEQDPNISNGEEE------EEKEPGEVGTHN--DNQERKTELPREHANSKQEEDNTQSDD 242
           ++ + N  NGE +       EKE  EV   N  D  E+  E     A   + E+  Q +D
Sbjct: 74  EDYNENAKNGEAKITEAPASEKEIVEVKEENIEDATEKGGEKKEAVAAEVKNEEEDQKED 133

Query: 243 ILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKTGL 302
             +++++  +  K  +DE  + + +++ N N + E+       K  ++ +   ++GK   
Sbjct: 134 EEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKGNGEDGK--- 190

Query: 303 EAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDDYF 362
           E   + KE E++        + T DG         ++DG + GD    +G      +D  
Sbjct: 191 EKGEDEKEEEDR--------KETGDGKE-------NEDGKEKGDK--KEGKDVKVKED-- 231

Query: 363 IPSQAFLEAERAQSIAYHLKIEEQREKVHENENIGTTEPGEHQEAKKAENSSNEEETSSE 422
                                E++RE   E+E     E G+ +E  K E    EE+   E
Sbjct: 232 ---------------------EKEREDGKEDEGGNEEEAGKEKEDLKEEEEGKEEDEIKE 270


>gi|5031701 follistatin-like 3 glycoprotein precursor [Homo sapiens]
          Length = 263

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 30/83 (36%), Positives = 39/83 (46%), Gaps = 6/83 (7%)

Query: 432 SCMSFQCKRGHICKADQQGKPHCVCQDPVTCP-PTKPLDQVCGTDNQTYASSCHLFATKC 490
           SC    C R   C  DQ G  HCV      CP P+ P  ++CG +N TY SSCH+    C
Sbjct: 170 SCEHVVCPRPQSCVVDQTGSAHCVVCRAAPCPVPSSPGQELCGNNNVTYISSCHMRQATC 229

Query: 491 RLEGTKKGHQLQLDYFGACKSIP 513
            L     G  + + + G+C   P
Sbjct: 230 FL-----GRSIGVRHAGSCAGTP 247



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 29/81 (35%), Positives = 38/81 (46%), Gaps = 10/81 (12%)

Query: 431 DSCMSFQCKRGHICKADQQGKPHCVCQDPVTCPPTKPLDQVCGTDNQTYASSCHLFATKC 490
           DSC   +C  G  C+    G+P C C    +  P +   QVCG+D  TY   C L A +C
Sbjct: 97  DSCDGVECGPGKACRM-LGGRPRCECAPDCSGLPARL--QVCGSDGATYRDECELRAARC 153

Query: 491 RLEGTKKGH-QLQLDYFGACK 510
           R      GH  L + Y G C+
Sbjct: 154 R------GHPDLSVMYRGRCR 168


>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           8 [Homo sapiens]
          Length = 780

 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 74/384 (19%), Positives = 147/384 (38%), Gaps = 41/384 (10%)

Query: 50  EENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSA----EQGKSSSQELGLKDQEDSDG 105
           ++  ++  V    D   K +K + +K KE  HE+      EQ K+  +    K +E +  
Sbjct: 89  QQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREWERQKRREMARE 148

Query: 106 HLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQE 165
           H   +      +G    ++ + + + K+  E                +Q    +RE   E
Sbjct: 149 H---SRRERGNDGVCLFRDRLEQLERKRERER--------KMREQQKEQREQKERERRAE 197

Query: 166 QPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELP 225
           + R     +   S+ H     D  ++ +  + S       +E  E+G      + +    
Sbjct: 198 ERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEE 257

Query: 226 REHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVN 285
           R+  +  Q+  +++      ES      S  +E+E ++  +E+E +++ E EEE      
Sbjct: 258 RDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEE------ 311

Query: 286 KHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGV-------- 337
               E E + +E +TG    SN +E  E++  E    E ++D      NH +        
Sbjct: 312 ----EEEEEEEEEETG----SNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFD 363

Query: 338 --DDDGDDDGDDGGTDGPRHSA--SDDYFIPSQAFLEAERAQSIAYHLKIEEQREKVHEN 393
               + ++  ++ G   P+ SA    DY   S A    E  Q +  +L   +    V E 
Sbjct: 364 RDSGESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEF 423

Query: 394 ENIGTTEPGEHQEAKKAENSSNEE 417
           + +   E G +    +A++   +E
Sbjct: 424 QCLNRIEEGTYGVVYRAKDKKTDE 447



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 50/231 (21%), Positives = 79/231 (34%), Gaps = 56/231 (24%)

Query: 49  AEENEKETAVSTEDDSHHKAEKSSVLKSKEESH-EQSAEQGKSSSQELGLKDQEDSDGHL 107
           AEE  KE     E  +HH+  +       + SH  +S  +      ELG       DG  
Sbjct: 196 AEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELG-------DGRK 248

Query: 108 SVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQP 167
            V  E       L   +D+S+ + K             +S  +S+  ES +  EE +E  
Sbjct: 249 PVKEEKMEERDLLSDLQDISDSERK-------------TSSAESSSAESGSGSEEEEE-- 293

Query: 168 RNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPRE 227
                                            EEEEE+E G     ++ +E + E   E
Sbjct: 294 ---------------------------------EEEEEEEEGSTSEESEEEEEEEEEEEE 320

Query: 228 HANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEE 278
              S  EE + QS + + E +      +  E+      + + D  + E EE
Sbjct: 321 ETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEE 371



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 57/281 (20%), Positives = 104/281 (37%), Gaps = 38/281 (13%)

Query: 153 QQESITKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVG 212
           + +S+  +   Q   +   HH+ +   K  +  R +  + +        EE++K   E  
Sbjct: 79  EDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREW- 137

Query: 213 THNDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNS 272
                ++++ E+ REH  S++E  N   D +    D+  Q+ + +E E     Q++E   
Sbjct: 138 ----ERQKRREMAREH--SRRERGN---DGVCLFRDRLEQLERKRERERKMREQQKEQRE 188

Query: 273 NAEMEEENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGNTTP 332
             E E           +  E + +E +   E  ++H+   E    +      +      P
Sbjct: 189 QKERE-----------RRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPP 237

Query: 333 RNHGVDDDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIE------EQ 386
           R      DG     +   +        D     Q   ++ER  S A     E      E+
Sbjct: 238 RERFELGDGRKPVKEEKME------ERDLLSDLQDISDSERKTSSAESSSAESGSGSEEE 291

Query: 387 REKVHENENIGTT-----EPGEHQEAKKAENSSNEEETSSE 422
            E+  E E  G+T     E  E +E ++ E  SN EE S +
Sbjct: 292 EEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQ 332



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 42/168 (25%), Positives = 76/168 (45%), Gaps = 18/168 (10%)

Query: 25  SDHSKPTAETVAPDNTAIPSLRAEAEENEKE----TAVSTEDDSHHKAEKSSVLKSKEES 80
           S+    +AE+ + ++ +      E EE E+E    +  S E++   + E+     + EE+
Sbjct: 270 SERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEA 329

Query: 81  HEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDF 140
            EQSAE+   S +E+   ++ +++ HL V       E   D     SE  E+++ E T  
Sbjct: 330 SEQSAEE--VSEEEMSEDEERENENHLLV-----VPESRFDRDSGESEEAEEEVGEGT-- 380

Query: 141 LAPGVSSFTDSN---QQESITKREENQEQPRNYSHHQLNRSSKHSQGL 185
             P  S+ T+ +      +++  E  QE P+     Q  RS +  Q L
Sbjct: 381 --PQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCL 426


>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           5 [Homo sapiens]
          Length = 748

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 72/376 (19%), Positives = 147/376 (39%), Gaps = 33/376 (8%)

Query: 58  VSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTE 117
           +S ++  HH+ ++    K +  SH  SAE GK +  +   ++ E    H     + A  E
Sbjct: 57  MSRKEKVHHRKDEKRKEKRRHRSH--SAEGGKHARVKEKEREHERRKRHREEQ-DKARRE 113

Query: 118 GTLDIKEDMSEPQEKKLSENTDFLA---PGVSSFTDSNQQESITKREENQEQPRNYSHHQ 174
                + +M+    ++  +  + L           +  +++   K  E + + R      
Sbjct: 114 WERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREA 173

Query: 175 LNRSSKHSQGLR-DQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPREHANSKQ 233
               S H + +R D  ++ +  + S       +E  E+G      + +    R+  +  Q
Sbjct: 174 RREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQ 233

Query: 234 EEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQETEW 293
           +  +++      ES      S  +E+E ++  +E+E +++ E EEE          E E 
Sbjct: 234 DISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEE----------EEEE 283

Query: 294 QSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGV----------DDDGDD 343
           + +E +TG    SN +E  E++  E    E ++D      NH +            + ++
Sbjct: 284 EEEEEETG----SNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEE 339

Query: 344 DGDDGGTDGPRHSA--SDDYFIPSQAFLEAERAQSIAYHLKIEEQREKVHENENIGTTEP 401
             ++ G   P+ SA    DY   S A    E  Q +  +L   +    V E + +   E 
Sbjct: 340 AEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEE 399

Query: 402 GEHQEAKKAENSSNEE 417
           G +    +A++   +E
Sbjct: 400 GTYGVVYRAKDKKTDE 415



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 50/231 (21%), Positives = 79/231 (34%), Gaps = 56/231 (24%)

Query: 49  AEENEKETAVSTEDDSHHKAEKSSVLKSKEESH-EQSAEQGKSSSQELGLKDQEDSDGHL 107
           AEE  KE     E  +HH+  +       + SH  +S  +      ELG       DG  
Sbjct: 164 AEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELG-------DGRK 216

Query: 108 SVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQP 167
            V  E       L   +D+S+ + K             +S  +S+  ES +  EE +E  
Sbjct: 217 PVKEEKMEERDLLSDLQDISDSERK-------------TSSAESSSAESGSGSEEEEE-- 261

Query: 168 RNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPRE 227
                                            EEEEE+E G     ++ +E + E   E
Sbjct: 262 ---------------------------------EEEEEEEEGSTSEESEEEEEEEEEEEE 288

Query: 228 HANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEE 278
              S  EE + QS + + E +      +  E+      + + D  + E EE
Sbjct: 289 ETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEE 339



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 42/168 (25%), Positives = 76/168 (45%), Gaps = 18/168 (10%)

Query: 25  SDHSKPTAETVAPDNTAIPSLRAEAEENEKE----TAVSTEDDSHHKAEKSSVLKSKEES 80
           S+    +AE+ + ++ +      E EE E+E    +  S E++   + E+     + EE+
Sbjct: 238 SERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEA 297

Query: 81  HEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDF 140
            EQSAE+   S +E+   ++ +++ HL V       E   D     SE  E+++ E T  
Sbjct: 298 SEQSAEE--VSEEEMSEDEERENENHLLV-----VPESRFDRDSGESEEAEEEVGEGT-- 348

Query: 141 LAPGVSSFTDSN---QQESITKREENQEQPRNYSHHQLNRSSKHSQGL 185
             P  S+ T+ +      +++  E  QE P+     Q  RS +  Q L
Sbjct: 349 --PQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCL 394



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 64/353 (18%), Positives = 131/353 (37%), Gaps = 54/353 (15%)

Query: 92  SQELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDS 151
           S+   L++ E  D  + + +  +P       +ED  E +     E  D LA         
Sbjct: 9   SKRDSLEEGELRDHRMEITIRNSPYR-----REDSMEDR----GEEDDSLAIKPPQQMSR 59

Query: 152 NQQESITKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEV 211
            ++    K E+ +E+ R+ SH     S++  +  R +  + +        EE++K   E 
Sbjct: 60  KEKVHHRKDEKRKEKRRHRSH-----SAEGGKHARVKEKEREHERRKRHREEQDKARREW 114

Query: 212 GTHNDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDN 271
                 ++++ E+ REH  S++E D  +  +   E ++     KM+E + +Q  Q++ + 
Sbjct: 115 -----ERQKRREMAREH--SRRERDRLEQLERKRERER-----KMREQQKEQREQKERER 162

Query: 272 SNAEMEEENASN--VNKH-----------IQETEWQSQEGKTGLEAIS---NHKETEEKT 315
              E  +E  +   V+ H           ++ + W     +   E        K  +E+ 
Sbjct: 163 RAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEK 222

Query: 316 VSEALLMEPTDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQ 375
           + E  L+    D + + R     +    +   G  +       ++           E   
Sbjct: 223 MEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEE-----------EEGS 271

Query: 376 SIAYHLKIEEQREKVHENENIGTTEPGEHQ-EAKKAENSSNEEETSSEGNMRV 427
           +     + EE+ E+  E     + E  E   E    E  S +EE  +E ++ V
Sbjct: 272 TSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLV 324


>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           2 [Homo sapiens]
          Length = 782

 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 72/376 (19%), Positives = 147/376 (39%), Gaps = 33/376 (8%)

Query: 58  VSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTE 117
           +S ++  HH+ ++    K +  SH  SAE GK +  +   ++ E    H     + A  E
Sbjct: 91  MSRKEKVHHRKDEKRKEKRRHRSH--SAEGGKHARVKEKEREHERRKRHREEQ-DKARRE 147

Query: 118 GTLDIKEDMSEPQEKKLSENTDFLA---PGVSSFTDSNQQESITKREENQEQPRNYSHHQ 174
                + +M+    ++  +  + L           +  +++   K  E + + R      
Sbjct: 148 WERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREA 207

Query: 175 LNRSSKHSQGLR-DQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPREHANSKQ 233
               S H + +R D  ++ +  + S       +E  E+G      + +    R+  +  Q
Sbjct: 208 RREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQ 267

Query: 234 EEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQETEW 293
           +  +++      ES      S  +E+E ++  +E+E +++ E EEE          E E 
Sbjct: 268 DISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEE----------EEEE 317

Query: 294 QSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGV----------DDDGDD 343
           + +E +TG    SN +E  E++  E    E ++D      NH +            + ++
Sbjct: 318 EEEEEETG----SNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEE 373

Query: 344 DGDDGGTDGPRHSA--SDDYFIPSQAFLEAERAQSIAYHLKIEEQREKVHENENIGTTEP 401
             ++ G   P+ SA    DY   S A    E  Q +  +L   +    V E + +   E 
Sbjct: 374 AEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLNRIEE 433

Query: 402 GEHQEAKKAENSSNEE 417
           G +    +A++   +E
Sbjct: 434 GTYGVVYRAKDKKTDE 449



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 50/231 (21%), Positives = 79/231 (34%), Gaps = 56/231 (24%)

Query: 49  AEENEKETAVSTEDDSHHKAEKSSVLKSKEESH-EQSAEQGKSSSQELGLKDQEDSDGHL 107
           AEE  KE     E  +HH+  +       + SH  +S  +      ELG       DG  
Sbjct: 198 AEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELG-------DGRK 250

Query: 108 SVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQP 167
            V  E       L   +D+S+ + K             +S  +S+  ES +  EE +E  
Sbjct: 251 PVKEEKMEERDLLSDLQDISDSERK-------------TSSAESSSAESGSGSEEEEE-- 295

Query: 168 RNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPRE 227
                                            EEEEE+E G     ++ +E + E   E
Sbjct: 296 ---------------------------------EEEEEEEEGSTSEESEEEEEEEEEEEE 322

Query: 228 HANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEE 278
              S  EE + QS + + E +      +  E+      + + D  + E EE
Sbjct: 323 ETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEE 373



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 71/394 (18%), Positives = 148/394 (37%), Gaps = 56/394 (14%)

Query: 52  NEKET-AVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVN 110
           +EK++  V T D+   + ++    + K E         + S ++  L++ E  D  + + 
Sbjct: 3   DEKDSWKVKTLDEILQEKKRRKEQEEKAEIKRLKNSDDRDSKRD-SLEEGELRDHRMEIT 61

Query: 111 LEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRNY 170
           +  +P       +ED  E +     E  D LA          ++    K E+ +E+ R+ 
Sbjct: 62  IRNSPYR-----REDSMEDR----GEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHR 112

Query: 171 SHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPREHAN 230
           SH     S++  +  R +  + +        EE++K   E       ++++ E+ REH  
Sbjct: 113 SH-----SAEGGKHARVKEKEREHERRKRHREEQDKARREW-----ERQKRREMAREH-- 160

Query: 231 SKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASN--VNKH- 287
           S++E D  +  +   E ++     KM+E + +Q  Q++ +    E  +E  +   V+ H 
Sbjct: 161 SRRERDRLEQLERKRERER-----KMREQQKEQREQKERERRAEERRKEREARREVSAHH 215

Query: 288 ----------IQETEWQSQEGKTGLEAIS---NHKETEEKTVSEALLMEPTDDGNTTPRN 334
                     ++ + W     +   E        K  +E+ + E  L+    D + + R 
Sbjct: 216 RTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERK 275

Query: 335 HGVDDDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIEEQREKVHENE 394
               +    +   G  +       ++           E   +     + EE+ E+  E  
Sbjct: 276 TSSAESSSAESGSGSEEEEEEEEEEE-----------EEGSTSEESEEEEEEEEEEEEET 324

Query: 395 NIGTTEPGEHQ-EAKKAENSSNEEETSSEGNMRV 427
              + E  E   E    E  S +EE  +E ++ V
Sbjct: 325 GSNSEEASEQSAEEVSEEEMSEDEERENENHLLV 358



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 42/168 (25%), Positives = 76/168 (45%), Gaps = 18/168 (10%)

Query: 25  SDHSKPTAETVAPDNTAIPSLRAEAEENEKE----TAVSTEDDSHHKAEKSSVLKSKEES 80
           S+    +AE+ + ++ +      E EE E+E    +  S E++   + E+     + EE+
Sbjct: 272 SERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEA 331

Query: 81  HEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDF 140
            EQSAE+   S +E+   ++ +++ HL V       E   D     SE  E+++ E T  
Sbjct: 332 SEQSAEE--VSEEEMSEDEERENENHLLV-----VPESRFDRDSGESEEAEEEVGEGT-- 382

Query: 141 LAPGVSSFTDSN---QQESITKREENQEQPRNYSHHQLNRSSKHSQGL 185
             P  S+ T+ +      +++  E  QE P+     Q  RS +  Q L
Sbjct: 383 --PQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCL 428


>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
          Length = 780

 Score = 58.2 bits (139), Expect = 2e-08
 Identities = 73/376 (19%), Positives = 148/376 (39%), Gaps = 35/376 (9%)

Query: 58  VSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTE 117
           +S ++  HH+ ++    K +  SH  SAE GK +   +  ++ E    H     + A  E
Sbjct: 91  MSRKEKVHHRKDEKRKEKCRHHSH--SAEGGKHA--RVKEREHERRKRHREEQ-DKARRE 145

Query: 118 GTLDIKEDMSEPQEKKLSENTDFLA---PGVSSFTDSNQQESITKREENQEQPRNYSHHQ 174
                + +M+    ++  +  + L           +  +++   K  E + + R      
Sbjct: 146 WERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREA 205

Query: 175 LNRSSKHSQGLR-DQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPREHANSKQ 233
               S H + +R D  ++ +  + S       +E  E+G      + +    R+  +  Q
Sbjct: 206 RREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQ 265

Query: 234 EEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQETEW 293
           +  +++      ES      S  +E+E ++  +E+E +++ E EEE          E E 
Sbjct: 266 DISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEE----------EEEE 315

Query: 294 QSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGV----------DDDGDD 343
           + +E +TG    SN +E  E++  E    E ++D      NH +            + ++
Sbjct: 316 EEEEEETG----SNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEE 371

Query: 344 DGDDGGTDGPRHSA--SDDYFIPSQAFLEAERAQSIAYHLKIEEQREKVHENENIGTTEP 401
             ++ G   P+ SA    DY   S A L  E  Q +  +L   +    V E + +   E 
Sbjct: 372 AEEEVGEGTPQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCLNRIEE 431

Query: 402 GEHQEAKKAENSSNEE 417
           G +    +A++   +E
Sbjct: 432 GTYGVVYRAKDKKTDE 447



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 50/231 (21%), Positives = 79/231 (34%), Gaps = 56/231 (24%)

Query: 49  AEENEKETAVSTEDDSHHKAEKSSVLKSKEESH-EQSAEQGKSSSQELGLKDQEDSDGHL 107
           AEE  KE     E  +HH+  +       + SH  +S  +      ELG       DG  
Sbjct: 196 AEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELG-------DGRK 248

Query: 108 SVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQP 167
            V  E       L   +D+S+ + K             +S  +S+  ES +  EE +E  
Sbjct: 249 PVKEEKMEERDLLSDLQDISDSERK-------------TSSAESSSAESGSGSEEEEE-- 293

Query: 168 RNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPRE 227
                                            EEEEE+E G     ++ +E + E   E
Sbjct: 294 ---------------------------------EEEEEEEEGSTSEESEEEEEEEEEEEE 320

Query: 228 HANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEE 278
              S  EE + QS + + E +      +  E+      + + D  + E EE
Sbjct: 321 ETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEE 371



 Score = 41.2 bits (95), Expect = 0.003
 Identities = 73/390 (18%), Positives = 147/390 (37%), Gaps = 60/390 (15%)

Query: 61  EDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDS------DGHLSVNLEYA 114
           E DS        +L+ K+   EQ   + K+  + L   D  DS      +G L  +    
Sbjct: 4   EKDSWKVKTLDEILQEKKRRKEQ---EEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI 60

Query: 115 PTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQ 174
               +   +ED  E +     E  D LA          ++    K E+ +E+ R++SH  
Sbjct: 61  TIRNSPYRREDSMEDR----GEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSA 116

Query: 175 LNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPREHANSKQE 234
                KH++ ++++ ++ +  +     EE++K   E       ++++ E+ REH  S++E
Sbjct: 117 --EGGKHAR-VKEREHERRKRH----REEQDKARREW-----ERQKRREMAREH--SRRE 162

Query: 235 EDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASN--VNKH----- 287
            D  +  +   E ++     KM+E + +Q  Q++ +    E  +E  +   V+ H     
Sbjct: 163 RDRLEQLERKRERER-----KMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMR 217

Query: 288 ------IQETEWQSQEGKTGLEAIS---NHKETEEKTVSEALLMEPTDDGNTTPRNHGVD 338
                 ++ + W     +   E        K  +E+ + E  L+    D + + R     
Sbjct: 218 EDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSA 277

Query: 339 DDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIEEQREKVHENENIGT 398
           +    +   G  +       ++           E   +     + EE+ E+  E     +
Sbjct: 278 ESSSAESGSGSEEEEEEEEEEE-----------EEGSTSEESEEEEEEEEEEEEETGSNS 326

Query: 399 TEPGEHQ-EAKKAENSSNEEETSSEGNMRV 427
            E  E   E    E  S +EE  +E ++ V
Sbjct: 327 EEASEQSAEEVSEEEMSEDEERENENHLLV 356



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 42/168 (25%), Positives = 75/168 (44%), Gaps = 18/168 (10%)

Query: 25  SDHSKPTAETVAPDNTAIPSLRAEAEENEKE----TAVSTEDDSHHKAEKSSVLKSKEES 80
           S+    +AE+ + ++ +      E EE E+E    +  S E++   + E+     + EE+
Sbjct: 270 SERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEA 329

Query: 81  HEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDF 140
            EQSAE+   S +E+   ++ +++ HL V       E   D     SE  E+++ E T  
Sbjct: 330 SEQSAEE--VSEEEMSEDEERENENHLLV-----VPESRFDRDSGESEEAEEEVGEGT-- 380

Query: 141 LAPGVSSFTDSN---QQESITKREENQEQPRNYSHHQLNRSSKHSQGL 185
             P  S+ T+ +      ++   E  QE P+     Q  RS +  Q L
Sbjct: 381 --PQSSALTEGDYVPDSPALLPIELKQELPKYLPALQGCRSVEEFQCL 426


>gi|253970456 HIV-1 Tat specific factor 1 [Homo sapiens]
          Length = 755

 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 78/340 (22%), Positives = 138/340 (40%), Gaps = 41/340 (12%)

Query: 18  PTNARLLSDHSKPTAETVAPDNTAIPSLRAEAEENEKETAVSTEDDSHHKAEKSSVLKSK 77
           P+ AR  S+H  P+   +    TA      E  + +K     TED    + E +S   +K
Sbjct: 396 PSRARHFSEH--PSTSKMNAQETATGMAFEEPIDEKKFE--KTEDGGEFE-EGASENNAK 450

Query: 78  EESHEQSAEQG--KSSSQELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLS 135
           E S E+ AE+G  +  S+E   K   +       + E  P  G+   +ED  + + KK +
Sbjct: 451 ESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGS---EEDSPKKESKKKT 507

Query: 136 ENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDP 195
              D    G++       ++ + K  E +  P           +K S+    +   ++D 
Sbjct: 508 LKNDCEENGLA----KESEDDLNKESEEEVGP-----------TKESEEDDSEKESDEDC 552

Query: 196 NISNGEEEEEKEPGEVGTHNDNQER--KTELPREHANSKQEEDNTQSDDILEESDQPTQV 253
           +    E+  E+E  E G   D  E   + EL     + + EE+++++ +  ++  +    
Sbjct: 553 SEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLD 612

Query: 254 SKMQEDEFDQGNQEQEDNSNAEMEEENASNV-NKHIQETEWQSQEGKTGLEAISNHKETE 312
            +  E EFD+ + E+E+      EE+    V +    E E +    + GLEA    K+ E
Sbjct: 613 EEGSEREFDEDSDEKEE------EEDTYEKVFDDESDEKEDEEYADEKGLEAAD--KKAE 664

Query: 313 EKTVSEALLMEPTDDGNTTPRNHGVDDDG-----DDDGDD 347
           E    E L  E  D  +       V+D       DDD ++
Sbjct: 665 EGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNE 704



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 61/305 (20%), Positives = 120/305 (39%), Gaps = 57/305 (18%)

Query: 47  AEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESH----EQSAEQGKSSSQELGLKDQED 102
           ++ E  E      +E+DS  K  K   LK+  E +    E   +  K S +E+G   + +
Sbjct: 481 SQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESE 540

Query: 103 SDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREE 162
            D            +   +  ED SE Q +  SE           F ++  ++ + +   
Sbjct: 541 ED------------DSEKESDEDCSEKQSEDGSER---------EFEENGLEKDLDEEGS 579

Query: 163 NQEQPRNYSHHQLNRSSKHSQGLRDQGNQ--------EQDPNISNGEEEEEKEPGEVGTH 214
            +E   N    +L  +   +    D G++        E++ +  + E+EEE++  E    
Sbjct: 580 EKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFD 639

Query: 215 NDNQERKTELPRE----HANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQE--- 267
           +++ E++ E   +     A  K+ E+    + + EESD        +EDE   G +    
Sbjct: 640 DESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDD-------KEDEDADGKEVEDA 692

Query: 268 -----QEDNSNAEMEEENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLM 322
                ++D+SN ++ +E   +  K   +++ +   G  G     + +E    T S  +L 
Sbjct: 693 DEKLFEDDDSNEKLFDEEEDSSEKLFDDSDERGTLGGFG-----SVEEGPLSTGSSFILS 747

Query: 323 EPTDD 327
              DD
Sbjct: 748 SDDDD 752



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 77/383 (20%), Positives = 148/383 (38%), Gaps = 45/383 (11%)

Query: 56  TAVSTEDDSHHKAEK----SSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNL 111
           T    E+ S  + E+     + L + E +         S+S+  G         H S + 
Sbjct: 351 TDYQVEETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSK 410

Query: 112 EYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYS 171
             A    T    E   EP ++K  E T+         +++N +ES  ++E  +  P   S
Sbjct: 411 MNAQETATGMAFE---EPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKES 467

Query: 172 HHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPREHANS 231
                +  +  +G   Q   E+   +   EE+  K+  +  T  ++ E       E+  +
Sbjct: 468 EEGCPK--RGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCE-------ENGLA 518

Query: 232 KQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQET 291
           K+ ED+               ++K  E+E     + +ED+S  E +E+ +   ++   E 
Sbjct: 519 KESEDD---------------LNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSER 563

Query: 292 EWQSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHG----VDDDG-----D 342
           E++    +  L+   + KE  E  + + L  E  D  N+   + G    +D++G     D
Sbjct: 564 EFEENGLEKDLDEEGSEKELHENVLDKEL--EENDSENSEFEDDGSEKVLDEEGSEREFD 621

Query: 343 DDGDDGGTDGPRH-SASDDYFIPSQAFLEAERAQSIAYHLKIEE--QREKVHENENIGTT 399
           +D D+   +   +    DD     +    A+     A   K EE    EK+ E  +    
Sbjct: 622 EDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKED 681

Query: 400 EPGEHQEAKKAENSSNEEETSSE 422
           E  + +E + A+    E++ S+E
Sbjct: 682 EDADGKEVEDADEKLFEDDDSNE 704



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 51/229 (22%), Positives = 94/229 (41%), Gaps = 34/229 (14%)

Query: 45  LRAEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSD 104
           L  E+EE    T  S EDDS  ++++    K  E+  E+  E       E GL+   D +
Sbjct: 525 LNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFE-------ENGLEKDLDEE 577

Query: 105 GHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQ 164
           G      E    E  LD      +  E+  SEN++F   G     D    E     + ++
Sbjct: 578 GS-----EKELHENVLD------KELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDE 626

Query: 165 EQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISN--GEEEEEKEPGEVGTHNDNQERKT 222
           ++    ++ ++           D+ ++++D   ++  G E  +K+  E        E   
Sbjct: 627 KEEEEDTYEKV---------FDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESD 677

Query: 223 ELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDN 271
           +   E A+ K+ ED   +D+ L E D   +  K+ ++E D   +  +D+
Sbjct: 678 DKEDEDADGKEVED---ADEKLFEDDDSNE--KLFDEEEDSSEKLFDDS 721


>gi|21361437 HIV-1 Tat specific factor 1 [Homo sapiens]
          Length = 755

 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 78/340 (22%), Positives = 138/340 (40%), Gaps = 41/340 (12%)

Query: 18  PTNARLLSDHSKPTAETVAPDNTAIPSLRAEAEENEKETAVSTEDDSHHKAEKSSVLKSK 77
           P+ AR  S+H  P+   +    TA      E  + +K     TED    + E +S   +K
Sbjct: 396 PSRARHFSEH--PSTSKMNAQETATGMAFEEPIDEKKFE--KTEDGGEFE-EGASENNAK 450

Query: 78  EESHEQSAEQG--KSSSQELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLS 135
           E S E+ AE+G  +  S+E   K   +       + E  P  G+   +ED  + + KK +
Sbjct: 451 ESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKESEEGNPVRGS---EEDSPKKESKKKT 507

Query: 136 ENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDP 195
              D    G++       ++ + K  E +  P           +K S+    +   ++D 
Sbjct: 508 LKNDCEENGLA----KESEDDLNKESEEEVGP-----------TKESEEDDSEKESDEDC 552

Query: 196 NISNGEEEEEKEPGEVGTHNDNQER--KTELPREHANSKQEEDNTQSDDILEESDQPTQV 253
           +    E+  E+E  E G   D  E   + EL     + + EE+++++ +  ++  +    
Sbjct: 553 SEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSENSEFEDDGSEKVLD 612

Query: 254 SKMQEDEFDQGNQEQEDNSNAEMEEENASNV-NKHIQETEWQSQEGKTGLEAISNHKETE 312
            +  E EFD+ + E+E+      EE+    V +    E E +    + GLEA    K+ E
Sbjct: 613 EEGSEREFDEDSDEKEE------EEDTYEKVFDDESDEKEDEEYADEKGLEAAD--KKAE 664

Query: 313 EKTVSEALLMEPTDDGNTTPRNHGVDDDG-----DDDGDD 347
           E    E L  E  D  +       V+D       DDD ++
Sbjct: 665 EGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNE 704



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 61/305 (20%), Positives = 120/305 (39%), Gaps = 57/305 (18%)

Query: 47  AEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESH----EQSAEQGKSSSQELGLKDQED 102
           ++ E  E      +E+DS  K  K   LK+  E +    E   +  K S +E+G   + +
Sbjct: 481 SQKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESE 540

Query: 103 SDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREE 162
            D            +   +  ED SE Q +  SE           F ++  ++ + +   
Sbjct: 541 ED------------DSEKESDEDCSEKQSEDGSER---------EFEENGLEKDLDEEGS 579

Query: 163 NQEQPRNYSHHQLNRSSKHSQGLRDQGNQ--------EQDPNISNGEEEEEKEPGEVGTH 214
            +E   N    +L  +   +    D G++        E++ +  + E+EEE++  E    
Sbjct: 580 EKELHENVLDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFD 639

Query: 215 NDNQERKTELPRE----HANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQE--- 267
           +++ E++ E   +     A  K+ E+    + + EESD        +EDE   G +    
Sbjct: 640 DESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDD-------KEDEDADGKEVEDA 692

Query: 268 -----QEDNSNAEMEEENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLM 322
                ++D+SN ++ +E   +  K   +++ +   G  G     + +E    T S  +L 
Sbjct: 693 DEKLFEDDDSNEKLFDEEEDSSEKLFDDSDERGTLGGFG-----SVEEGPLSTGSSFILS 747

Query: 323 EPTDD 327
              DD
Sbjct: 748 SDDDD 752



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 77/383 (20%), Positives = 148/383 (38%), Gaps = 45/383 (11%)

Query: 56  TAVSTEDDSHHKAEK----SSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNL 111
           T    E+ S  + E+     + L + E +         S+S+  G         H S + 
Sbjct: 351 TDYQVEETSREREERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSK 410

Query: 112 EYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYS 171
             A    T    E   EP ++K  E T+         +++N +ES  ++E  +  P   S
Sbjct: 411 MNAQETATGMAFE---EPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKES 467

Query: 172 HHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPREHANS 231
                +  +  +G   Q   E+   +   EE+  K+  +  T  ++ E       E+  +
Sbjct: 468 EEGCPK--RGFEGSCSQKESEEGNPVRGSEEDSPKKESKKKTLKNDCE-------ENGLA 518

Query: 232 KQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQET 291
           K+ ED+               ++K  E+E     + +ED+S  E +E+ +   ++   E 
Sbjct: 519 KESEDD---------------LNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSER 563

Query: 292 EWQSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHG----VDDDG-----D 342
           E++    +  L+   + KE  E  + + L  E  D  N+   + G    +D++G     D
Sbjct: 564 EFEENGLEKDLDEEGSEKELHENVLDKEL--EENDSENSEFEDDGSEKVLDEEGSEREFD 621

Query: 343 DDGDDGGTDGPRH-SASDDYFIPSQAFLEAERAQSIAYHLKIEE--QREKVHENENIGTT 399
           +D D+   +   +    DD     +    A+     A   K EE    EK+ E  +    
Sbjct: 622 EDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESDDKED 681

Query: 400 EPGEHQEAKKAENSSNEEETSSE 422
           E  + +E + A+    E++ S+E
Sbjct: 682 EDADGKEVEDADEKLFEDDDSNE 704



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 51/229 (22%), Positives = 94/229 (41%), Gaps = 34/229 (14%)

Query: 45  LRAEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSD 104
           L  E+EE    T  S EDDS  ++++    K  E+  E+  E       E GL+   D +
Sbjct: 525 LNKESEEEVGPTKESEEDDSEKESDEDCSEKQSEDGSEREFE-------ENGLEKDLDEE 577

Query: 105 GHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQ 164
           G      E    E  LD      +  E+  SEN++F   G     D    E     + ++
Sbjct: 578 GS-----EKELHENVLD------KELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDE 626

Query: 165 EQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISN--GEEEEEKEPGEVGTHNDNQERKT 222
           ++    ++ ++           D+ ++++D   ++  G E  +K+  E        E   
Sbjct: 627 KEEEEDTYEKV---------FDDESDEKEDEEYADEKGLEAADKKAEEGDADEKLFEESD 677

Query: 223 ELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDN 271
           +   E A+ K+ ED   +D+ L E D   +  K+ ++E D   +  +D+
Sbjct: 678 DKEDEDADGKEVED---ADEKLFEDDDSNE--KLFDEEEDSSEKLFDDS 721


>gi|121256621 dentin matrix acidic phosphoprotein 1 isoform 2
           precursor [Homo sapiens]
          Length = 497

 Score = 57.8 bits (138), Expect = 3e-08
 Identities = 96/468 (20%), Positives = 170/468 (36%), Gaps = 90/468 (19%)

Query: 1   MKTGLFFLCLLGTAAAIPTNARLLSDHSKPTAETVAPDNTA-IPSLRAE--AEENEKETA 57
           MK  +  + L G + A+P   R  ++ S+ + E       A  P L  E  ++  + E  
Sbjct: 1   MKISILLMFLWGLSCALPVT-RYQNNESEDSEEWKGHLAQAPTPPLANEDPSDSTQSEEG 59

Query: 58  VSTEDDSHHKAEKSSVLKS-------KEESHEQSAEQ---------GKSSSQELG---LK 98
           + ++D  +         +S       K++  + S +          G    QE G   L 
Sbjct: 60  LGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLG 119

Query: 99  DQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESIT 158
             EDSD  +  + E AP +G    ++  SE +E    +  D    G  S  +S  +E   
Sbjct: 120 SDEDSDDTIQASEESAP-QGQDSAQDTTSESRELDNEDRVDSKPEGGDSTQESESEEHWV 178

Query: 159 KREENQEQPRNYSHHQLNRSSKHSQG--LRDQGNQEQDPNISNGEEE---------EEKE 207
               + E             S H  G  L D+G Q  DP     E           + KE
Sbjct: 179 GGGSDGE-------------SSHGDGSELDDEGMQSDDPESIRSERGNSRMNSAGMKSKE 225

Query: 208 PGEVGTHNDNQERKTELPREHANSK--------QEEDNTQSDD---ILEESDQPTQVSKM 256
            GE     + Q+       EH + K        +E+D ++ DD   + E     T+ S  
Sbjct: 226 SGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDDNNTMEEVKSDSTENSNS 285

Query: 257 QEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTV 316
           ++    Q  ++ + +S  + +E  +   ++++     +S + +  L +  N  E++E+ V
Sbjct: 286 RDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQ-EANLSSQENSSESQEEVV 344

Query: 317 SEALLMEPTDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQS 376
           SE+         N  P    V+D  D D  +   +   H+ S                  
Sbjct: 345 SESR------GDNPDPTTSYVEDQEDSDSSE---EDSSHTLS------------------ 377

Query: 377 IAYHLKIEEQREKVHENENIGTTEPGEHQEAKKAENSSNEEETSSEGN 424
              H K E + E+     +       E  E+ + ENSS++E   S  +
Sbjct: 378 ---HSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSS 422



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 64/311 (20%), Positives = 134/311 (43%), Gaps = 23/311 (7%)

Query: 50  EENEKETAVSTEDDSHHKAEKSSVLKSKE--ESHEQSAEQGKSSSQELGLKDQED-SDGH 106
           E  + +   S   +  +    S+ +KSKE  E+ EQ+  Q    SQ L    ++      
Sbjct: 197 EGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSR 256

Query: 107 LSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQ--QESITKRE-EN 163
           +S   + +  +    ++E  S+  E   S +T    P   S  DS +  +E++++ E +N
Sbjct: 257 ISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQN 316

Query: 164 QEQPRNYSHHQLNRSSKHSQG------LRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDN 217
            + P + S  + N SS+ +        + +      DP  S  E++E+ +  E  + +  
Sbjct: 317 VDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTL 376

Query: 218 QERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEME 277
              K+E       S++E+ +++S + L  S++  +  + +     +G Q    ++ ++ E
Sbjct: 377 SHSKSE-------SREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSE 429

Query: 278 EENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGV 337
           E ++   +   Q++  +S+E     E+ S+ +E  +    E    + T D      N  +
Sbjct: 430 ESHSEEDDSDSQDSS-RSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAY---HNKPI 485

Query: 338 DDDGDDDGDDG 348
            D  D+D  DG
Sbjct: 486 GDQDDNDCQDG 496



 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 51/239 (21%), Positives = 103/239 (43%), Gaps = 23/239 (9%)

Query: 46  RAEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDG 105
           R+E ++N     V ++   +  +  + + + + +S   S E  K   + L  ++ ++ DG
Sbjct: 263 RSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSK---ENLSQEESQNVDG 319

Query: 106 HLSVNLEYAPTEGTLDIKEDMSEPQEKKLSE----NTDFLAPGVSSFTDSNQQE------ 155
             S + +    E  L  +E+ SE QE+ +SE    N D     V    DS+  E      
Sbjct: 320 PSSESSQ----EANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHT 375

Query: 156 -SITKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTH 214
            S +K E  +EQ  + S   LN S +  +   D+ +  Q+   S+    E +        
Sbjct: 376 LSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEE 435

Query: 215 NDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQ---GNQEQED 270
           +D+  + +   +E +NS + + +++ D  L+  +   +  K+  D +     G+Q+  D
Sbjct: 436 DDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIE--IESRKLTVDAYHNKPIGDQDDND 492



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 36/185 (19%), Positives = 80/185 (43%), Gaps = 21/185 (11%)

Query: 24  LSDHSKPTAETVAPDNTAIPSLRAEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESH-- 81
           LS       +  + +++   +L ++   +E +  V +E    +    +S ++ +E+S   
Sbjct: 309 LSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSS 368

Query: 82  EQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFL 141
           E+ +    S S+    ++Q DS+   S+N     +E + +  ED +   ++ L  +    
Sbjct: 369 EEDSSHTLSHSKSESREEQADSESSESLNF----SEESPESPEDENSSSQEGLQSH---- 420

Query: 142 APGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGE 201
               SS  +S  +ES ++ +++  Q         +RS + S     + + E+D  + N E
Sbjct: 421 ----SSSAESQSEESHSEEDDSDSQ-------DSSRSKEDSNSTESKSSSEEDGQLKNIE 469

Query: 202 EEEEK 206
            E  K
Sbjct: 470 IESRK 474



 Score = 36.6 bits (83), Expect = 0.076
 Identities = 50/269 (18%), Positives = 100/269 (37%), Gaps = 27/269 (10%)

Query: 176 NRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPREHANS---- 231
           N  S+ S+  +    Q   P ++N E+  +    E G  +D+ +    L    + S    
Sbjct: 24  NNESEDSEEWKGHLAQAPTPPLAN-EDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKG 82

Query: 232 ---KQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHI 288
              K ++++   DD   + D        QE    +   +++ +   +  EE+A       
Sbjct: 83  GDDKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSA 142

Query: 289 QETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGVDDDGDDDGDDG 348
           Q+T  +S+E            + E++  S+    + T +  +     G   DG+    DG
Sbjct: 143 QDTTSESRE-----------LDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDG 191

Query: 349 GTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIEEQREKVHE--NENIGTTEPGEHQE 406
                    SDD   P     E   ++  +  +K +E  E   +   ++ G ++  EH  
Sbjct: 192 SELDDEGMQSDD---PESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPS 248

Query: 407 AK---KAENSSNEEETSSEGNMRVHAVDS 432
            K   K+  S  ++ +  + N  +  V S
Sbjct: 249 RKIFRKSRISEEDDRSELDDNNTMEEVKS 277


>gi|4758172 dentin matrix acidic phosphoprotein 1 isoform 1
           precursor [Homo sapiens]
          Length = 513

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 97/485 (20%), Positives = 174/485 (35%), Gaps = 108/485 (22%)

Query: 1   MKTGLFFLCLLGTAAAIPTNARLLSDHSKPTAETVAPDNTAIPSLRAEAEENEKETAVST 60
           MK  +  + L G + A+P   R  ++ S+ + E       A P+   E+ E+ + + VS+
Sbjct: 1   MKISILLMFLWGLSCALPVT-RYQNNESEDSEEWKGHLAQA-PTPPLESSESSEGSKVSS 58

Query: 61  EDDSHHKAEKSSVLKS---------------------------KEESHEQSAEQ------ 87
           E+ ++     S+  +                            K++  + S +       
Sbjct: 59  EEQANEDPSDSTQSEEGLGSDDHQYIYRLAGGFSRSTGKGGDDKDDDEDDSGDDTFGDDD 118

Query: 88  ---GKSSSQELG---LKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFL 141
              G    QE G   L   EDSD  +  + E AP +G    ++  SE +E    +  D  
Sbjct: 119 SGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAP-QGQDSAQDTTSESRELDNEDRVDSK 177

Query: 142 APGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSKHSQG--LRDQGNQEQDPNISN 199
             G  S  +S  +E       + E             S H  G  L D+G Q  DP    
Sbjct: 178 PEGGDSTQESESEEHWVGGGSDGE-------------SSHGDGSELDDEGMQSDDPESIR 224

Query: 200 GEEE---------EEKEPGEVGTHNDNQERKTELPREHANSK--------QEEDNTQSDD 242
            E           + KE GE     + Q+       EH + K        +E+D ++ DD
Sbjct: 225 SERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSRISEEDDRSELDD 284

Query: 243 ---ILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQETEWQSQEGK 299
              + E     T+ S  ++    Q  ++ + +S  + +E  +   ++++     +S + +
Sbjct: 285 NNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQNVDGPSSESSQ-E 343

Query: 300 TGLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASD 359
             L +  N  E++E+ VSE+         N  P    V+D  D D  +   +   H+ S 
Sbjct: 344 ANLSSQENSSESQEEVVSESR------GDNPDPTTSYVEDQEDSDSSE---EDSSHTLS- 393

Query: 360 DYFIPSQAFLEAERAQSIAYHLKIEEQREKVHENENIGTTEPGEHQEAKKAENSSNEEET 419
                               H K E + E+     +       E  E+ + ENSS++E  
Sbjct: 394 --------------------HSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGL 433

Query: 420 SSEGN 424
            S  +
Sbjct: 434 QSHSS 438



 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 64/311 (20%), Positives = 134/311 (43%), Gaps = 23/311 (7%)

Query: 50  EENEKETAVSTEDDSHHKAEKSSVLKSKE--ESHEQSAEQGKSSSQELGLKDQED-SDGH 106
           E  + +   S   +  +    S+ +KSKE  E+ EQ+  Q    SQ L    ++      
Sbjct: 213 EGMQSDDPESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRKIFRKSR 272

Query: 107 LSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQ--QESITKRE-EN 163
           +S   + +  +    ++E  S+  E   S +T    P   S  DS +  +E++++ E +N
Sbjct: 273 ISEEDDRSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSKENLSQEESQN 332

Query: 164 QEQPRNYSHHQLNRSSKHSQG------LRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDN 217
            + P + S  + N SS+ +        + +      DP  S  E++E+ +  E  + +  
Sbjct: 333 VDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHTL 392

Query: 218 QERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEME 277
              K+E       S++E+ +++S + L  S++  +  + +     +G Q    ++ ++ E
Sbjct: 393 SHSKSE-------SREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSE 445

Query: 278 EENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGV 337
           E ++   +   Q++  +S+E     E+ S+ +E  +    E    + T D      N  +
Sbjct: 446 ESHSEEDDSDSQDSS-RSKEDSNSTESKSSSEEDGQLKNIEIESRKLTVDAY---HNKPI 501

Query: 338 DDDGDDDGDDG 348
            D  D+D  DG
Sbjct: 502 GDQDDNDCQDG 512



 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 51/239 (21%), Positives = 103/239 (43%), Gaps = 23/239 (9%)

Query: 46  RAEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDG 105
           R+E ++N     V ++   +  +  + + + + +S   S E  K   + L  ++ ++ DG
Sbjct: 279 RSELDDNNTMEEVKSDSTENSNSRDTGLSQPRRDSKGDSQEDSK---ENLSQEESQNVDG 335

Query: 106 HLSVNLEYAPTEGTLDIKEDMSEPQEKKLSE----NTDFLAPGVSSFTDSNQQE------ 155
             S + +    E  L  +E+ SE QE+ +SE    N D     V    DS+  E      
Sbjct: 336 PSSESSQ----EANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSSEEDSSHT 391

Query: 156 -SITKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTH 214
            S +K E  +EQ  + S   LN S +  +   D+ +  Q+   S+    E +        
Sbjct: 392 LSHSKSESREEQADSESSESLNFSEESPESPEDENSSSQEGLQSHSSSAESQSEESHSEE 451

Query: 215 NDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQ---GNQEQED 270
           +D+  + +   +E +NS + + +++ D  L+  +   +  K+  D +     G+Q+  D
Sbjct: 452 DDSDSQDSSRSKEDSNSTESKSSSEEDGQLKNIE--IESRKLTVDAYHNKPIGDQDDND 508



 Score = 39.3 bits (90), Expect = 0.012
 Identities = 36/185 (19%), Positives = 80/185 (43%), Gaps = 21/185 (11%)

Query: 24  LSDHSKPTAETVAPDNTAIPSLRAEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESH-- 81
           LS       +  + +++   +L ++   +E +  V +E    +    +S ++ +E+S   
Sbjct: 325 LSQEESQNVDGPSSESSQEANLSSQENSSESQEEVVSESRGDNPDPTTSYVEDQEDSDSS 384

Query: 82  EQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFL 141
           E+ +    S S+    ++Q DS+   S+N     +E + +  ED +   ++ L  +    
Sbjct: 385 EEDSSHTLSHSKSESREEQADSESSESLNF----SEESPESPEDENSSSQEGLQSH---- 436

Query: 142 APGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGE 201
               SS  +S  +ES ++ +++  Q         +RS + S     + + E+D  + N E
Sbjct: 437 ----SSSAESQSEESHSEEDDSDSQ-------DSSRSKEDSNSTESKSSSEEDGQLKNIE 485

Query: 202 EEEEK 206
            E  K
Sbjct: 486 IESRK 490



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 49/267 (18%), Positives = 101/267 (37%), Gaps = 32/267 (11%)

Query: 178 SSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPREHANS------ 231
           SS+ S+G +    ++ + + S+  + EE      G  +D+ +    L    + S      
Sbjct: 47  SSESSEGSKVSSEEQANEDPSDSTQSEE------GLGSDDHQYIYRLAGGFSRSTGKGGD 100

Query: 232 -KQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQE 290
            K ++++   DD   + D        QE    +   +++ +   +  EE+A       Q+
Sbjct: 101 DKDDDEDDSGDDTFGDDDSGPGPKDRQEGGNSRLGSDEDSDDTIQASEESAPQGQDSAQD 160

Query: 291 TEWQSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGVDDDGDDDGDDGGT 350
           T  +S+E            + E++  S+    + T +  +     G   DG+    DG  
Sbjct: 161 TTSESRE-----------LDNEDRVDSKPEGGDSTQESESEEHWVGGGSDGESSHGDGSE 209

Query: 351 DGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIEEQREKVHE--NENIGTTEPGEHQEAK 408
                  SDD   P     E   ++  +  +K +E  E   +   ++ G ++  EH   K
Sbjct: 210 LDDEGMQSDD---PESIRSERGNSRMNSAGMKSKESGENSEQANTQDSGGSQLLEHPSRK 266

Query: 409 ---KAENSSNEEETSSEGNMRVHAVDS 432
              K+  S  ++ +  + N  +  V S
Sbjct: 267 IFRKSRISEEDDRSELDDNNTMEEVKS 293


>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 436

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 53/279 (18%), Positives = 112/279 (40%), Gaps = 18/279 (6%)

Query: 48  EAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHL 107
           E +  E+E  V  E +   + ++  V + + +  EQ  + G+   Q   + +QE+  G  
Sbjct: 156 EGQVREQEGQVR-EQEGQVREQEGQVREQEGQVREQEGQMGEQEGQ---MGEQEEQMGEQ 211

Query: 108 SVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQP 167
              ++    E  +  +E+    QE+++ E  + +           Q+E + K+EE   + 
Sbjct: 212 EEQMQ--KQEEQMGEQEEQMRKQEEQMGEQEEQV---------QKQEEQVQKQEEQMRKQ 260

Query: 168 RNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTE---L 224
                 Q  +  +  + +  Q  Q +    +  +EE+ +E  E     + Q R+ E    
Sbjct: 261 EEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMR 320

Query: 225 PREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNV 284
            +E    KQEE   +  + + E  +     + Q  E ++  Q+QE+    + E+      
Sbjct: 321 EQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEE 380

Query: 285 NKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLME 323
               QE + + QE + G +     ++ E+    E  + E
Sbjct: 381 QMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGE 419



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 49/271 (18%), Positives = 116/271 (42%), Gaps = 22/271 (8%)

Query: 48  EAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAE----QGKSSSQELGLKDQEDS 103
           E +  E+E  V  E +   + ++  V + + +  EQ  +    +G+   QE  +++QE  
Sbjct: 114 EGQVREQEGQVR-EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG- 171

Query: 104 DGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREEN 163
                   +    EG +  +E     QE ++ E    +  G        Q+E + K+EE 
Sbjct: 172 --------QVREQEGQVREQEGQVREQEGQMGEQEGQM--GEQEEQMGEQEEQMQKQEEQ 221

Query: 164 QEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDN-QERKT 222
             +       +  R  +   G +++  Q+Q+  +   EE+  K+  ++    +  +E++ 
Sbjct: 222 MGE-----QEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEE 276

Query: 223 ELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENAS 282
           ++ ++   ++QEE   + ++ + E ++  +  + Q  E ++  +EQE+    + E+    
Sbjct: 277 QMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQ 336

Query: 283 NVNKHIQETEWQSQEGKTGLEAISNHKETEE 313
                 Q+ +   QE + G +     K+ E+
Sbjct: 337 KEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQ 367



 Score = 50.1 bits (118), Expect = 7e-06
 Identities = 45/261 (17%), Positives = 109/261 (41%), Gaps = 25/261 (9%)

Query: 48  EAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHL 107
           E +  E+E  +  +++     E+   ++ +EE   +  EQ +   +++G ++++      
Sbjct: 191 EGQMGEQEGQMGEQEEQ--MGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEE 248

Query: 108 SVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQP 167
            V  +    E  +  +E+    QE+++ E  + +   +     + Q+E   ++EE   + 
Sbjct: 249 QVQKQ----EEQMRKQEEQMREQEEQMREQEEQM---LKQKEQTEQEEQTGEQEEQMREQ 301

Query: 168 RNYSHHQLNRSSKHSQGLRDQGNQ---------EQDPNISNGEEEEEKEPGEVGTHNDNQ 218
                 Q  +  +  + +R+Q  Q         EQ   +   +E+  K+  ++G   +  
Sbjct: 302 EEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQM 361

Query: 219 ERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEE 278
           +++ E  R     KQEE   + ++ + + ++  Q+ K +E   +Q  Q  E       +E
Sbjct: 362 QKQEEQVR-----KQEEQMRKQEEQMRKQEE--QMRKQEEQMGEQKEQMGEQKEQMREQE 414

Query: 279 ENASNVNKHIQETEWQSQEGK 299
           E      + +++ E    E K
Sbjct: 415 EQMGEQKEQMRKQEEHMGEQK 435



 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 58/292 (19%), Positives = 118/292 (40%), Gaps = 36/292 (12%)

Query: 27  HSKPTAETVAPDNTAIPSLRAEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAE 86
           H K     +  D   +P    E +  E+E  V  E +   + ++  V + + +  EQ   
Sbjct: 33  HIKELKRKLETDKIPLPQ---EGQVREQEGQVR-EQEGQVREQEGQVREQEGQVREQ--- 85

Query: 87  QGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVS 146
           +G+   QE  +++QE          +    EG +  +E     QE ++ E    +     
Sbjct: 86  EGQVREQEGQVREQEG---------QVREQEGQVREQEGQVREQEGQVREQEGQV----- 131

Query: 147 SFTDSNQQESITKREENQEQPRNYSHHQLNRSSKHSQG-LRDQGNQ--EQDPNISNGEEE 203
                 +QE   + +E Q + +     +     +  +G +R+Q  Q  EQ+  +   E +
Sbjct: 132 -----REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 186

Query: 204 EEKEPGEVGTHNDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQ 263
             ++ G++G     QE +     E    ++E+   Q + + E+ +Q   + K +E   +Q
Sbjct: 187 VREQEGQMG----EQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQ---MRKQEEQMGEQ 239

Query: 264 GNQEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKT 315
             Q Q+     + +EE      + ++E E Q +E +  +       E EE+T
Sbjct: 240 EEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQT 291



 Score = 49.7 bits (117), Expect = 9e-06
 Identities = 49/269 (18%), Positives = 107/269 (39%), Gaps = 21/269 (7%)

Query: 48  EAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELG-----LKDQED 102
           E E   +E      +      E+   +  +EE   +  EQ +   +++G     ++ QE+
Sbjct: 175 EQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEE 234

Query: 103 SDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREE 162
             G     ++    E  +  +E+    QE+++ E  + +           Q+E + K++E
Sbjct: 235 QMGEQEEQVQ--KQEEQVQKQEEQMRKQEEQMREQEEQMR---------EQEEQMLKQKE 283

Query: 163 NQEQPRNYSHHQLNRSSKHSQGLRDQGNQ--EQDPNISNGEEEEEKEPGEVGTHNDNQ-E 219
             EQ       +     +  Q +R+Q  Q  EQ+  +   EE+  K+  ++    +   E
Sbjct: 284 QTEQEEQTGEQEEQMREQEEQ-MREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWE 342

Query: 220 RKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEE 279
           +K ++ ++     ++E+  Q  +  +   Q  Q+ K +E    Q  Q ++       ++E
Sbjct: 343 QKEQMWKQEEQMGEQEEQMQKQEE-QVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKE 401

Query: 280 NASNVNKHIQETEWQSQEGKTGLEAISNH 308
                 + ++E E Q  E K  +     H
Sbjct: 402 QMGEQKEQMREQEEQMGEQKEQMRKQEEH 430



 Score = 48.5 bits (114), Expect = 2e-05
 Identities = 43/220 (19%), Positives = 93/220 (42%), Gaps = 18/220 (8%)

Query: 46  RAEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDG 105
           + E +  E+E  V  +++   K E+  + K +E+  EQ  +  +   Q L  K+Q + + 
Sbjct: 231 KQEEQMGEQEEQVQKQEEQVQKQEEQ-MRKQEEQMREQEEQMREQEEQMLKQKEQTEQE- 288

Query: 106 HLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQE 165
                      E T + +E M E QE+++ E  + +        +  Q+E + K+EE   
Sbjct: 289 -----------EQTGEQEEQMRE-QEEQMREQEEQMREQEEQMRE--QEEQMGKQEEQMW 334

Query: 166 QPRNYSHHQLNRSSKHSQ--GLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTE 223
           + +     Q  +  K  +  G +++  Q+Q+  +   EE+  K+  ++    +   ++ E
Sbjct: 335 EQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEE 394

Query: 224 LPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQ 263
              E      E+     +   +  +Q  Q+ K +E   +Q
Sbjct: 395 QMGEQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQ 434



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 68/395 (17%), Positives = 149/395 (37%), Gaps = 28/395 (7%)

Query: 46  RAEAEENEKETAVSTEDDSHHKAEKSSV------LKSKEESHE-QSAEQGKSSSQELGLK 98
           R   EE +++ A   E+    + EKS +      LK K E+ +    ++G+   QE  ++
Sbjct: 3   RITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVR 62

Query: 99  DQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESIT 158
           +QE          +    EG +  +E     QE ++ E    +           +QE   
Sbjct: 63  EQEG---------QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV---REQEGQV 110

Query: 159 KREENQEQPRNYSHHQLNRSSKHSQG-LRDQGNQ--EQDPNISNGEEEEEKEPGEVGTHN 215
           + +E Q + +     +     +  +G +R+Q  Q  EQ+  +   E +  ++ G+V    
Sbjct: 111 REQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQE 170

Query: 216 DNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQV----SKMQEDEFDQGNQEQEDN 271
                +    RE     +E++    +   +  +Q  Q+     +MQ+ E   G QE++  
Sbjct: 171 GQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMR 230

Query: 272 SNAEMEEENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGNTT 331
              E   E    V K  QE + Q QE +   +     ++ E+    E  +++  +     
Sbjct: 231 KQEEQMGEQEEQVQK--QEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQE 288

Query: 332 PRNHGVDDDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIEEQREKVH 391
            +    ++   +  +       +    ++     +  +  +  Q      ++ EQ+E++ 
Sbjct: 289 EQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMW 348

Query: 392 ENENIGTTEPGEHQEAKKAENSSNEEETSSEGNMR 426
           + E     +  + Q+ ++      E+    E  MR
Sbjct: 349 KQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMR 383



 Score = 35.0 bits (79), Expect = 0.22
 Identities = 26/159 (16%), Positives = 64/159 (40%), Gaps = 11/159 (6%)

Query: 48  EAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQ--EDSDG 105
           + E+  ++     E +   + ++  + + +E+  EQ  + GK   Q    K+Q  E  + 
Sbjct: 287 QEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQ 346

Query: 106 HLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQE 165
                 +    E  +  +E+    QE+++ +  + +           Q+E + K+EE   
Sbjct: 347 MWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMR---------KQEEQMRKQEEQMG 397

Query: 166 QPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEE 204
           + +     Q  +  +  + + +Q  Q +      GE++E
Sbjct: 398 EQKEQMGEQKEQMREQEEQMGEQKEQMRKQEEHMGEQKE 436


>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           9 [Homo sapiens]
          Length = 771

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 70/380 (18%), Positives = 144/380 (37%), Gaps = 42/380 (11%)

Query: 50  EENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSV 109
           ++  ++  V    D   K +K + +K KE  HE+     +   +    + + +      +
Sbjct: 89  QQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKA---RREWERQKRREM 145

Query: 110 NLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRN 169
             E++  E     + +    +E+K+ E                +Q    +RE   E+ R 
Sbjct: 146 AREHSRRERDRLEQLERKRERERKMREQ-------------QKEQREQKERERRAEERRK 192

Query: 170 YSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPREHA 229
               +   S+ H     D  ++ +  + S       +E  E+G      + +    R+  
Sbjct: 193 EREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLL 252

Query: 230 NSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQ 289
           +  Q+  +++      ES      S  +E+E ++  +E+E +++ E EEE          
Sbjct: 253 SDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEE---------- 302

Query: 290 ETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGV----------DD 339
           E E + +E +TG    SN +E  E++  E    E ++D      NH +            
Sbjct: 303 EEEEEEEEEETG----SNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSG 358

Query: 340 DGDDDGDDGGTDGPRHSA--SDDYFIPSQAFLEAERAQSIAYHLKIEEQREKVHENENIG 397
           + ++  ++ G   P+ SA    DY   S A    E  Q +  +L   +    V E + + 
Sbjct: 359 ESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLN 418

Query: 398 TTEPGEHQEAKKAENSSNEE 417
             E G +    +A++   +E
Sbjct: 419 RIEEGTYGVVYRAKDKKTDE 438



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 54/293 (18%), Positives = 109/293 (37%), Gaps = 42/293 (14%)

Query: 153 QQESITKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVG 212
           + +S+  +   Q   +   HH+ +   K  +  R +  + +        EE++K   E  
Sbjct: 79  EDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREW- 137

Query: 213 THNDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNS 272
                ++++ E+ REH  S++E D  +  +   E ++     KM+E + +Q  Q++ +  
Sbjct: 138 ----ERQKRREMAREH--SRRERDRLEQLERKRERER-----KMREQQKEQREQKERERR 186

Query: 273 NAE--MEEENASNVNKH-----------IQETEWQSQEGKTGLEAI---SNHKETEEKTV 316
             E   E E    V+ H           ++ + W     +   E        K  +E+ +
Sbjct: 187 AEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKM 246

Query: 317 SEALLMEPTDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQS 376
            E  L+    D + + R     +    +   G  +                  E E   S
Sbjct: 247 EERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEE------------EEEEEGS 294

Query: 377 IAYHLKIEEQREKVHENENIGTTEPGEHQEAKKA--ENSSNEEETSSEGNMRV 427
            +   + EE+ E+  E E    +E    Q A++   E  S +EE  +E ++ V
Sbjct: 295 TSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLV 347



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 50/231 (21%), Positives = 79/231 (34%), Gaps = 56/231 (24%)

Query: 49  AEENEKETAVSTEDDSHHKAEKSSVLKSKEESH-EQSAEQGKSSSQELGLKDQEDSDGHL 107
           AEE  KE     E  +HH+  +       + SH  +S  +      ELG       DG  
Sbjct: 187 AEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELG-------DGRK 239

Query: 108 SVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQP 167
            V  E       L   +D+S+ + K             +S  +S+  ES +  EE +E  
Sbjct: 240 PVKEEKMEERDLLSDLQDISDSERK-------------TSSAESSSAESGSGSEEEEE-- 284

Query: 168 RNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPRE 227
                                            EEEEE+E G     ++ +E + E   E
Sbjct: 285 ---------------------------------EEEEEEEEGSTSEESEEEEEEEEEEEE 311

Query: 228 HANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEE 278
              S  EE + QS + + E +      +  E+      + + D  + E EE
Sbjct: 312 ETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEE 362



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 42/168 (25%), Positives = 76/168 (45%), Gaps = 18/168 (10%)

Query: 25  SDHSKPTAETVAPDNTAIPSLRAEAEENEKE----TAVSTEDDSHHKAEKSSVLKSKEES 80
           S+    +AE+ + ++ +      E EE E+E    +  S E++   + E+     + EE+
Sbjct: 261 SERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEA 320

Query: 81  HEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDF 140
            EQSAE+   S +E+   ++ +++ HL V       E   D     SE  E+++ E T  
Sbjct: 321 SEQSAEE--VSEEEMSEDEERENENHLLV-----VPESRFDRDSGESEEAEEEVGEGT-- 371

Query: 141 LAPGVSSFTDSN---QQESITKREENQEQPRNYSHHQLNRSSKHSQGL 185
             P  S+ T+ +      +++  E  QE P+     Q  RS +  Q L
Sbjct: 372 --PQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCL 417


>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           4 [Homo sapiens]
          Length = 737

 Score = 57.4 bits (137), Expect = 4e-08
 Identities = 70/380 (18%), Positives = 144/380 (37%), Gaps = 42/380 (11%)

Query: 50  EENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSV 109
           ++  ++  V    D   K +K + +K KE  HE+     +   +    + + +      +
Sbjct: 55  QQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKA---RREWERQKRREM 111

Query: 110 NLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRN 169
             E++  E     + +    +E+K+ E                +Q    +RE   E+ R 
Sbjct: 112 AREHSRRERDRLEQLERKRERERKMREQ-------------QKEQREQKERERRAEERRK 158

Query: 170 YSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPREHA 229
               +   S+ H     D  ++ +  + S       +E  E+G      + +    R+  
Sbjct: 159 EREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLL 218

Query: 230 NSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQ 289
           +  Q+  +++      ES      S  +E+E ++  +E+E +++ E EEE          
Sbjct: 219 SDLQDISDSERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEE---------- 268

Query: 290 ETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGV----------DD 339
           E E + +E +TG    SN +E  E++  E    E ++D      NH +            
Sbjct: 269 EEEEEEEEEETG----SNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSG 324

Query: 340 DGDDDGDDGGTDGPRHSA--SDDYFIPSQAFLEAERAQSIAYHLKIEEQREKVHENENIG 397
           + ++  ++ G   P+ SA    DY   S A    E  Q +  +L   +    V E + + 
Sbjct: 325 ESEEAEEEVGEGTPQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCLN 384

Query: 398 TTEPGEHQEAKKAENSSNEE 417
             E G +    +A++   +E
Sbjct: 385 RIEEGTYGVVYRAKDKKTDE 404



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 54/293 (18%), Positives = 109/293 (37%), Gaps = 42/293 (14%)

Query: 153 QQESITKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVG 212
           + +S+  +   Q   +   HH+ +   K  +  R +  + +        EE++K   E  
Sbjct: 45  EDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARREW- 103

Query: 213 THNDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNS 272
                ++++ E+ REH  S++E D  +  +   E ++     KM+E + +Q  Q++ +  
Sbjct: 104 ----ERQKRREMAREH--SRRERDRLEQLERKRERER-----KMREQQKEQREQKERERR 152

Query: 273 NAE--MEEENASNVNKH-----------IQETEWQSQEGKTGLEAI---SNHKETEEKTV 316
             E   E E    V+ H           ++ + W     +   E        K  +E+ +
Sbjct: 153 AEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKM 212

Query: 317 SEALLMEPTDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQS 376
            E  L+    D + + R     +    +   G  +                  E E   S
Sbjct: 213 EERDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEEE------------EEEEEGS 260

Query: 377 IAYHLKIEEQREKVHENENIGTTEPGEHQEAKKA--ENSSNEEETSSEGNMRV 427
            +   + EE+ E+  E E    +E    Q A++   E  S +EE  +E ++ V
Sbjct: 261 TSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLV 313



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 50/231 (21%), Positives = 79/231 (34%), Gaps = 56/231 (24%)

Query: 49  AEENEKETAVSTEDDSHHKAEKSSVLKSKEESH-EQSAEQGKSSSQELGLKDQEDSDGHL 107
           AEE  KE     E  +HH+  +       + SH  +S  +      ELG       DG  
Sbjct: 153 AEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELG-------DGRK 205

Query: 108 SVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQP 167
            V  E       L   +D+S+ + K             +S  +S+  ES +  EE +E  
Sbjct: 206 PVKEEKMEERDLLSDLQDISDSERK-------------TSSAESSSAESGSGSEEEEE-- 250

Query: 168 RNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPRE 227
                                            EEEEE+E G     ++ +E + E   E
Sbjct: 251 ---------------------------------EEEEEEEEGSTSEESEEEEEEEEEEEE 277

Query: 228 HANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEE 278
              S  EE + QS + + E +      +  E+      + + D  + E EE
Sbjct: 278 ETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLVVPESRFDRDSGESEE 328



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 42/168 (25%), Positives = 76/168 (45%), Gaps = 18/168 (10%)

Query: 25  SDHSKPTAETVAPDNTAIPSLRAEAEENEKE----TAVSTEDDSHHKAEKSSVLKSKEES 80
           S+    +AE+ + ++ +      E EE E+E    +  S E++   + E+     + EE+
Sbjct: 227 SERKTSSAESSSAESGSGSEEEEEEEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEA 286

Query: 81  HEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDF 140
            EQSAE+   S +E+   ++ +++ HL V       E   D     SE  E+++ E T  
Sbjct: 287 SEQSAEE--VSEEEMSEDEERENENHLLV-----VPESRFDRDSGESEEAEEEVGEGT-- 337

Query: 141 LAPGVSSFTDSN---QQESITKREENQEQPRNYSHHQLNRSSKHSQGL 185
             P  S+ T+ +      +++  E  QE P+     Q  RS +  Q L
Sbjct: 338 --PQSSALTEGDYVPDSPALSPIELKQELPKYLPALQGCRSVEEFQCL 383


>gi|60097902 filaggrin [Homo sapiens]
          Length = 4061

 Score = 56.2 bits (134), Expect = 9e-08
 Identities = 88/412 (21%), Positives = 139/412 (33%), Gaps = 50/412 (12%)

Query: 55  ETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSD-GHL-SVNLE 112
           ET+   +  S H+  +SS  +     H+QSA+  + S+   G      SD GH  S   +
Sbjct: 362 ETSSRGQTASSHEQARSSPGERHGSGHQQSADSSRHSATGRGQASSAVSDRGHRGSSGSQ 421

Query: 113 YAPTEGTLDIKEDMS---------------EPQEKKLSENTDFLAPGVSSFTDSNQQESI 157
            + +EG  +  +  S               E    +  E +      +   +   Q +S 
Sbjct: 422 ASDSEGHSENSDTQSVSGHGKAGLRQQSHQESTRGRSGERSGRSGSSLYQVSTHEQPDSA 481

Query: 158 TKREENQEQPRNYSHHQLNR-SSKHSQGLRDQGNQEQDPNISNG------EEEEEKEPGE 210
             R       R  SHH+  R SS+HS     Q      P  S G       E+     G 
Sbjct: 482 HGRTGTSTGGRQGSHHEQARDSSRHSASQEGQDTIRGHPGSSRGGRQGSHHEQSVNRSGH 541

Query: 211 VGTHNDNQERKTELPREHAN------SKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQG 264
            G+H+ +   +      H        S+Q  +  QS D    S      +  Q D     
Sbjct: 542 SGSHHSHTTSQGRSDASHGQSGSRSASRQTRNEEQSGDGTRHSGSRHHEASSQADSSRHS 601

Query: 265 NQEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEP 324
              Q  +S         S+V++            +    A  NH  + +         E 
Sbjct: 602 QVGQGQSSGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHHGSAQ---------EQ 652

Query: 325 TDDGNTTPRNHGVDDDG-DDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKI 383
           + DG+  PR+H  D  G     D     G RH+ +       QA    E+A+S A     
Sbjct: 653 SRDGSRHPRSHHEDRAGHGHSADSSRKSGTRHTQNSS---SGQAASSHEQARSSAGERHG 709

Query: 384 EEQREKVHENENIGTTEPGEHQEAKK---AENSSNEEETSSEGNMRVHAVDS 432
              + +  ++     T  G+   A +      SS  + T SEG    H+ DS
Sbjct: 710 SRHQLQSADSSRHSGTGHGQASSAVRDSGHRGSSGSQATDSEG----HSEDS 757



 Score = 54.3 bits (129), Expect = 4e-07
 Identities = 76/401 (18%), Positives = 135/401 (33%), Gaps = 31/401 (7%)

Query: 27   HSKPTAETVAPDNTAIPSLRAEAEENEKETAV-STEDDSHHKAEKSSVLKSKEESHEQSA 85
            H+ P   + A    + P   +    NE+++   S    S H    +    S+     Q  
Sbjct: 1521 HTTPQGRSDASHGQSGPRSASRQTRNEEQSGDGSRHSGSRHHEPSTRAGSSRHSQVGQGE 1580

Query: 86   EQGKSSSQELG--LKDQEDSDGHLSVN---LEYAPTEGTLDIKEDMSEPQEKKLSENTDF 140
              G  +S+  G  +    DS+GH   +    E A        +E          S   D 
Sbjct: 1581 SAGSKTSRRQGSSVSQDRDSEGHSEDSERRSESASRNHYGSAREQSRHGSRNPRSHQEDR 1640

Query: 141  LAPGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNG 200
             + G S+  +S++Q      E +       S  Q   S     G R Q + +   +   G
Sbjct: 1641 ASHGHSA--ESSRQSGTRHAETSSGGQAASSQEQARSSPGERHGSRHQQSADSSTDSGTG 1698

Query: 201  EEEEEKEPGEVGTHNDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDE 260
              ++    G+ G    +  + ++                S+   EESD  +  +  Q   
Sbjct: 1699 RRQDSSVVGDSGNRGSSGSQASD----------------SEGHSEESDTQSVSAHGQAGP 1742

Query: 261  FDQGNQEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEAL 320
              Q +QE     + E    + S + +     + +S  G+TG  +    + +  +   ++ 
Sbjct: 1743 HQQSHQESTRGQSGERSGRSGSFLYQVSTHEQSESAHGRTG-PSTGGRQRSRHEQARDSS 1801

Query: 321  LMEPTDDGNTTPRNHGVDDDGDDDGD--DGGTDGPRHSASDDYFIPSQAFLEAERAQSIA 378
                + +G  T R H     G   G   +   D   HS S      SQ   +  R QS +
Sbjct: 1802 RHSASQEGQDTIRGHPGSSRGGRQGSHYEQSVDSSGHSGSHHSHTTSQERSDVSRGQSGS 1861

Query: 379  YHLKIEEQREKVHENENIGTTEPG-EHQEAKKAENSSNEEE 418
              +  + + EK       G+   G  H EA    +SS   +
Sbjct: 1862 RSVSRQTRNEK---QSGDGSRHSGSRHHEASSRADSSRHSQ 1899



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 84/429 (19%), Positives = 151/429 (35%), Gaps = 52/429 (12%)

Query: 57   AVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPT 116
            A S  D S H             S  Q +   + S  E    D E   G  S N   +  
Sbjct: 1240 AASWADSSRHSQVGQEQSSGSRTSRHQGSSVSQDSDSERHSDDSERLSGSASRNHHGSSR 1299

Query: 117  EGTLDIKEDMSEPQEKKLS--ENTDFLAPGVSSFTDSNQQ-ESITKREENQEQP--RNYS 171
            E + D        QE + S   + D      +  T+S+   ++++  E+ +  P  R+ S
Sbjct: 1300 EQSRDGSRHPGFHQEDRASHGHSADSSRQSGTHHTESSSHGQAVSSHEQARSSPGERHGS 1359

Query: 172  HHQLNR-SSKH--------SQGLRDQGNQ-EQDPNISNGE-EEEEKEPGEVGTHNDNQER 220
             HQ +  SS+H        S  +RD G++      ++N E   E+ +   V  H      
Sbjct: 1360 RHQQSADSSRHSGIGHRQASSAVRDSGHRGSSGSQVTNSEGHSEDSDTQSVSAHGQAGPH 1419

Query: 221  KTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEEN 280
            + +  +E A  +  E + +S   L       QVS  ++ E   G              E 
Sbjct: 1420 Q-QSHKESARGQSGESSGRSRSFL------YQVSSHEQSESTHGQTAPSTGGRQGSRHEQ 1472

Query: 281  ASNVNKHIQETEWQ---------SQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGNTT 331
            A N ++H    + Q         S+ G+ G    S H+++ +++         T     +
Sbjct: 1473 ARNSSRHSASQDGQDTIRGHPGSSRGGRQG----SYHEQSVDRSGHSGYHHSHTTPQGRS 1528

Query: 332  PRNHGVDD----DGDDDGDDGGTDGPRHSASDDYFIPSQA----FLEAERAQSIAYHLKI 383
              +HG             ++   DG RHS S  +   ++A      +  + +S       
Sbjct: 1529 DASHGQSGPRSASRQTRNEEQSGDGSRHSGSRHHEPSTRAGSSRHSQVGQGESAGSKTSR 1588

Query: 384  EEQREKVHENENIGTTEPGEHQEAKKAEN---SSNEEETSSEGNMRVHAVDSCMSFQCKR 440
             +      + ++ G +E  E +    + N   S+ E+      N R H  D     +   
Sbjct: 1589 RQGSSVSQDRDSEGHSEDSERRSESASRNHYGSAREQSRHGSRNPRSHQED-----RASH 1643

Query: 441  GHICKADQQ 449
            GH  ++ +Q
Sbjct: 1644 GHSAESSRQ 1652



 Score = 47.4 bits (111), Expect = 4e-05
 Identities = 81/408 (19%), Positives = 139/408 (34%), Gaps = 43/408 (10%)

Query: 55   ETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQ--EDSDGHLSVNLE 112
            ET+   +  S H+  +SS  +     H+QSA+  + S    G       DS    S   +
Sbjct: 3280 ETSSGGQAASSHEQARSSPGERHGSRHQQSADSSRHSGIPRGQASSAVRDSRHWGSSGSQ 3339

Query: 113  YAPTEGTLDIKEDMSE-------PQEKKLSENTDFLAPGVSSFTDS--------NQQESI 157
             + +EG  +  +  S        P ++   E+    + G S  + S         Q ES 
Sbjct: 3340 ASDSEGHSEESDTQSVSGHGQAGPHQQSHQESARDRSGGRSGRSGSFLYQVSTHEQSESA 3399

Query: 158  TKREENQEQPRNYSHHQLNR-SSKHSQGLRDQGNQEQDPNIS------NGEEEEEKEPGE 210
              R       R  SHH+  R SS+HS     Q      P  S      +  E+     G 
Sbjct: 3400 HGRTRTSTGRRQGSHHEQARDSSRHSASQEGQDTIRGHPGSSRRGRQGSHYEQSVDRSGH 3459

Query: 211  VGTHNDN--QERKTELPREHANSK----QEEDNTQSDDILEESDQPTQVSKMQEDEFDQG 264
             G+H+ +   + +++  R  + S+    Q  ++ QS D    S      +  Q D     
Sbjct: 3460 SGSHHSHTTSQGRSDASRGQSGSRSASRQTRNDEQSGDGSRHSWSHHHEASTQADSSRHS 3519

Query: 265  NQEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEP 324
               Q  ++         S+V++            +    A  NH+ + +         E 
Sbjct: 3520 QSGQGQSAGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHRGSAQ---------EQ 3570

Query: 325  TDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIE 384
            + DG+  P +H  D  G     +       H A +     + +  E  R+ +   H    
Sbjct: 3571 SRDGSRHPTSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAASSHEQARSSAGERHGSHH 3630

Query: 385  EQREKVHENENIGTTEPGEHQEAKKAENSSNEEETSSEGNMRVHAVDS 432
            +Q      +  IG  +            SS  + + SEG    H+ DS
Sbjct: 3631 QQSADSSRHSGIGHGQASSAVRDSGHRGSSGSQASDSEG----HSEDS 3674



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 85/429 (19%), Positives = 147/429 (34%), Gaps = 44/429 (10%)

Query: 25   SDHSKPTAE---TVAPDNTAIPSLRAEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESH 81
            S HS  T++     +  ++   S   +   +E+    S    S H    S    S     
Sbjct: 2490 SHHSHTTSQGRSDASHGHSGSRSASRQTRNDEQSGDGSRHSGSRHHEASSRADSSGHSQV 2549

Query: 82   EQSAEQGKSSSQELGLKDQEDSD--GHLSVNLEYAPTEGTL---DIKEDMSEPQEKKLSE 136
             Q   +G  +S+  G    +DSD  GH   +  ++ +         +E + +      S 
Sbjct: 2550 GQGQSEGPRTSRNWGSSFSQDSDSQGHSEDSERWSGSASRNHHGSAQEQLRDGSRHPRSH 2609

Query: 137  NTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPN 196
              D    G S+  DS++Q      + +       SH Q   S+    G   Q + +   +
Sbjct: 2610 QEDRAGHGHSA--DSSRQSGTRHTQTSSGGQAASSHEQARSSAGERHGSHHQQSADSSRH 2667

Query: 197  ISNGEEEEEKEPGEVGTHNDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKM 256
               G  +      + G             R ++ S+  ++   S+D    SD  +  +  
Sbjct: 2668 SGIGHGQASSAVRDSG------------HRGYSGSQASDNEGHSED----SDTQSVSAHG 2711

Query: 257  QEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKTGLEAI----SNHKETE 312
            Q     Q +QE     + E    + S + +     + +S  G TG        S H++ +
Sbjct: 2712 QAGSHQQSHQESARGRSGETSGHSGSFLYQVSTHEQSESSHGWTGPSTRGRQGSRHEQAQ 2771

Query: 313  EKTVSEALLMEPTDDGNTTPRNHGVDDDGDDDG--DDGGTDGPRHSASDDYFIPSQAFLE 370
            + +   A     + DG  T R H     G   G   +   D   HS S      SQ   +
Sbjct: 2772 DSSRHSA-----SQDGQDTIRGHPGSSRGGRQGYHHEHSVDSSGHSGSHHSHTTSQGRSD 2826

Query: 371  AERAQSIAYHLKIEEQREKVHENENIGTTEPG-EHQEAKKAENSSNEEET---SSEGNMR 426
            A R QS +   +   +  +  E    G+   G  H EA    + S   +     SEG+ R
Sbjct: 2827 ASRGQSGS---RSASRTTRNEEQSGDGSRHSGSRHHEASTHADISRHSQAVQGQSEGSRR 2883

Query: 427  VHAVDSCMS 435
                 S +S
Sbjct: 2884 SRRQGSSVS 2892



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 71/373 (19%), Positives = 113/373 (30%), Gaps = 37/373 (9%)

Query: 61   EDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTL 120
            +D S H A +    +     H   +  G+  S +   +   D  GH   +  +  ++G  
Sbjct: 2123 QDSSRHSASQEG--QDTIRGHPGPSRGGRQGSHQ---EQSVDRSGHSGSHHSHTTSQGRS 2177

Query: 121  DIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSK 180
            D     S  +               S  T   +Q     R          S    +R S 
Sbjct: 2178 DASRGQSGSRS-------------ASRKTYDKEQSGDGSRHSGSHHHEASSWADSSRHSL 2224

Query: 181  HSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPREHANSKQEEDNTQS 240
              QG +  G +   P  S+  ++ + E    G   D++ R     R H  S QE+    S
Sbjct: 2225 VGQG-QSSGPRTSRPRGSSVSQDSDSE----GHSEDSERRSGSASRNHHGSAQEQSRDGS 2279

Query: 241  DDILEESDQPTQVSKMQEDEFDQGNQEQEDNSN---AEMEEENASNVNKHIQETEWQSQE 297
                   +         E     G    E++S    A   E+  S+  +       QS +
Sbjct: 2280 RHPRSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAASSHEQARSSAGERHGSHHQQSAD 2339

Query: 298  GKTGLEAISNHKETEEKTVSEALLMEPT--DDGNTTPRNHGVDDDGDDDGDDGGTDGPRH 355
                    S H        S A+         G+    + G  +D D            H
Sbjct: 2340 S-------SRHSGIGHGQASSAVRDSGHRGSSGSQASDSEGHSEDSDTQSVSAHGQAGPH 2392

Query: 356  SASDDYFIPSQAFLEAERAQSIAYHLKIEEQREKVHENENIGTTEPGEHQEAKKAENSSN 415
              S       ++   + R+ S  Y +   EQ E  H     GT+  G      K    S+
Sbjct: 2393 QQSHQESTRGRSAGRSGRSGSFLYQVSTHEQSESAHGRT--GTSTGGRQGSHHKQARDSS 2450

Query: 416  EEETSSEGNMRVH 428
               TS EG   +H
Sbjct: 2451 RHSTSQEGQDTIH 2463



 Score = 45.8 bits (107), Expect = 1e-04
 Identities = 91/433 (21%), Positives = 149/433 (34%), Gaps = 52/433 (12%)

Query: 25   SDHSKPTAE---TVAPDNTAIPSLRAEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESH 81
            S HS  T++     +   +   S   +   +E+    S    SHH    +    S+    
Sbjct: 3462 SHHSHTTSQGRSDASRGQSGSRSASRQTRNDEQSGDGSRHSWSHHHEASTQADSSRHSQS 3521

Query: 82   EQSAEQGKSSSQELGLKDQEDSD--GHLSVNLEY---APTEGTLDIKEDMSEPQEKKLSE 136
             Q    G  +S+  G    +DSD  GH   +  +   A        +E   +      S 
Sbjct: 3522 GQGQSAGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSASRNHRGSAQEQSRDGSRHPTSH 3581

Query: 137  NTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSS---KHSQGLRDQGNQEQ 193
            + D    G S+    + ++S T   EN    +  S H+  RSS   +H    +   +  +
Sbjct: 3582 HEDRAGHGHSA---ESSRQSGTHHAENSSGGQAASSHEQARSSAGERHGSHHQQSADSSR 3638

Query: 194  DPNISNGEEEEE-KEPGEVGTHNDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQ 252
               I +G+     ++ G  G                ++  Q  D   S+   E+SD  + 
Sbjct: 3639 HSGIGHGQASSAVRDSGHRG----------------SSGSQASD---SEGHSEDSDTQSV 3679

Query: 253  VSKMQEDEFDQGNQEQEDNSNAEMEEENAS---NVNKHIQETEWQSQEG-KTGLEAISNH 308
             +  Q     Q +QE     +A     + S    V+ H Q      + G  TG    S H
Sbjct: 3680 SAHGQAGPHQQSHQESTRGRSAGRSGRSGSFLYQVSTHEQSESAHGRAGPSTGGRQGSRH 3739

Query: 309  KETEEKTVSEALLMEPTDDGNTTPRNHGVDDDGDDDGD--DGGTDGPRHSASDDYFIPSQ 366
            ++  + +   A     + +G  T R H     G   G   +   D   HS S      SQ
Sbjct: 3740 EQARDSSRHSA-----SQEGQDTIRGHPGSRRGGRQGSYHEQSVDRSGHSGSHHSHTTSQ 3794

Query: 367  AFLEAERAQSIAYHLKIEEQREKVHENENIGTTEPG-EHQEAKKAENSSNEEET---SSE 422
               +A   QS +     E + E   E    G+   G  H EA    +SS   ++    S 
Sbjct: 3795 GRSDASHGQSGSRSASRETRNE---EQSGDGSRHSGSRHHEASTQADSSRHSQSGQGESA 3851

Query: 423  GNMRVHAVDSCMS 435
            G+ R     S +S
Sbjct: 3852 GSRRSRRQGSSVS 3864



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 76/408 (18%), Positives = 135/408 (33%), Gaps = 39/408 (9%)

Query: 46   RAEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQ-------SAEQGKSSSQELGLK 98
            +A +   +  ++      SHH+ + +   +     H Q       S  +G S SQ    +
Sbjct: 1989 QAASSHEQARSSAGERHGSHHQLQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQASDSE 2048

Query: 99   DQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESIT 158
               +     SV+ +          KE       +    +  FL       +   Q ES  
Sbjct: 2049 GHSEDSDTQSVSAQGKAGPHQQSHKESARGQSGESSGRSGSFLY----QVSTHEQSESTH 2104

Query: 159  KREENQEQPRNYSHH-QLNRSSKHSQGLRDQGNQEQDPNISNG------EEEEEKEPGEV 211
             +       R  SH+ Q   SS+HS     Q      P  S G      +E+     G  
Sbjct: 2105 GQSAPSTGGRQGSHYDQAQDSSRHSASQEGQDTIRGHPGPSRGGRQGSHQEQSVDRSGHS 2164

Query: 212  GTHNDN--QERKTELPREHANSKQEE----DNTQSDDILEESDQPTQVSKMQEDEFDQGN 265
            G+H+ +   + +++  R  + S+       D  QS D    S      +    D      
Sbjct: 2165 GSHHSHTTSQGRSDASRGQSGSRSASRKTYDKEQSGDGSRHSGSHHHEASSWADSSRHSL 2224

Query: 266  QEQEDNSNAEMEEENASNVNKHIQ-ETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEP 324
              Q  +S         S+V++    E   +  E ++G  + ++H   +E++         
Sbjct: 2225 VGQGQSSGPRTSRPRGSSVSQDSDSEGHSEDSERRSGSASRNHHGSAQEQS--------- 2275

Query: 325  TDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIE 384
              DG+  PR+H  D  G     +       H A +     + +  E  R+ +   H    
Sbjct: 2276 -RDGSRHPRSHHEDRAGHGHSAESSRQSGTHHAENSSGGQAASSHEQARSSAGERHGSHH 2334

Query: 385  EQREKVHENENIGTTEPGEHQEAKKAENSSNEEETSSEGNMRVHAVDS 432
            +Q      +  IG  +            SS  + + SEG    H+ DS
Sbjct: 2335 QQSADSSRHSGIGHGQASSAVRDSGHRGSSGSQASDSEG----HSEDS 2378



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 73/384 (19%), Positives = 122/384 (31%), Gaps = 59/384 (15%)

Query: 62   DDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTLD 121
            D+S H A +    +     H  S+ +G+  S     +   D  GH   +  +  ++G  D
Sbjct: 827  DNSRHSASQDG--QDTIRGHPGSSRRGRQGSHH---EQSVDRSGHSGSHHSHTTSQGRSD 881

Query: 122  IKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRS--- 178
                 S  +                         S ++   N+EQ R+ S H  +R    
Sbjct: 882  ASRGQSGSR-------------------------SASRTTRNEEQSRDGSRHSGSRHHEA 916

Query: 179  ------SKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPREHANSK 232
                  S+HSQ    QG  E             ++    G   D++       R H  S 
Sbjct: 917  SSHADISRHSQA--GQGQSEGSRTSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSA 974

Query: 233  QEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSN---AEMEEENASNVNKHIQ 289
            QE+    S       +         +     G    E +S    A   E+  S+  +   
Sbjct: 975  QEQSRHGSRHPRSHHEDRAGHGHSADSSRQSGTPHAETSSGGQAASSHEQARSSPGERHG 1034

Query: 290  ETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEP--TDDGNTTPRNHGVDDDGDDDGDD 347
                QS +        S H     +  S A+         G+    + G  ++ D     
Sbjct: 1035 SRHQQSADS-------SRHSGIPRRQASSAVRDSGHWGSSGSQASDSEGHSEESDTQSVS 1087

Query: 348  G-GTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIEEQREKVH--ENENIGTTEPGEH 404
            G G DGP H  S        +   + R+ S  Y +   EQ E  H     + G  +   H
Sbjct: 1088 GHGQDGP-HQQSHQESARDWSGGRSGRSGSFIYQVSTHEQSESAHGRTRTSTGRRQGSHH 1146

Query: 405  QEAKKAENSSNEEETSSEGNMRVH 428
            ++A+ +   S  +E   +  +R H
Sbjct: 1147 EQARDSSRHSASQE--GQDTIRAH 1168



 Score = 44.3 bits (103), Expect = 4e-04
 Identities = 84/425 (19%), Positives = 148/425 (34%), Gaps = 65/425 (15%)

Query: 65   HHKAEK-------SSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTE 117
            HH+A         S  ++ + E   +S  QG S SQ+       DS+GH   +  ++ + 
Sbjct: 2858 HHEASTHADISRHSQAVQGQSEGSRRSRRQGSSVSQD------SDSEGHSEDSERWSGSA 2911

Query: 118  GTL---DIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQ 174
                    +E + +      S   D    G S+  DS++Q      + +       SH Q
Sbjct: 2912 SRNHHGSAQEQLRDGSRHPRSHQEDRAGHGHSA--DSSRQSGTRHTQTSSGGQAASSHEQ 2969

Query: 175  LNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPREHANSKQE 234
               S+    G   Q + +   +   G  +      + G             R ++ S+  
Sbjct: 2970 ARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSG------------HRGYSGSQAS 3017

Query: 235  EDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQETEWQ 294
            ++   S+D    SD  +  +  Q     Q +QE     + E    + S + +     + +
Sbjct: 3018 DNEGHSED----SDTQSVSAHGQAGSHQQSHQESARGRSGETSGHSGSFLYQVSTHEQSE 3073

Query: 295  SQEGKTGLEAI----SNHKETEEKTVSEALLMEPTDDGNTTPRNHGVDDDGDDDG--DDG 348
            S  G TG        S H++ ++ +   A     +  G  T R H     G   G   + 
Sbjct: 3074 SSHGWTGPSTRGRQGSRHEQAQDSSRHSA-----SQYGQDTIRGHPGSSRGGRQGYHHEH 3128

Query: 349  GTDGPRHSASDDYFIPSQAFLEAERAQ----SIAYHLKIEEQ-----REKVHENENIGT- 398
              D   HS S      SQ   +A R Q    S +   + EEQ     R  V  +    T 
Sbjct: 3129 SVDSSGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDSSRHSVSRHHEASTH 3188

Query: 399  TEPGEHQEA----------KKAENSSNEEETSSEGNMRVHAVDSCMSFQCKRGHICKADQ 448
             +   H +A           + + SS  +++ SEG+       S  + +  RG + +  +
Sbjct: 3189 ADISRHSQAVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSVQEQSR 3248

Query: 449  QGKPH 453
             G  H
Sbjct: 3249 HGSRH 3253



 Score = 43.9 bits (102), Expect = 5e-04
 Identities = 87/435 (20%), Positives = 147/435 (33%), Gaps = 84/435 (19%)

Query: 25   SDHSKPTAETVAPDNTAIPSLRAEAE--ENEKETAVSTEDD--SHHKAEK-------SSV 73
            S HS  T++  +  +      R+ +    NE+++  S+      HH+A         S  
Sbjct: 3138 SHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDSSRHSVSRHHEASTHADISRHSQA 3197

Query: 74   LKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKK 133
            ++ + E   +S  QG S SQ+       DS+GH                    SE  E+ 
Sbjct: 3198 VQGQSEGSRRSRRQGSSVSQD------SDSEGH--------------------SEDSER- 3230

Query: 134  LSENTDFLAPGVSSFTDSNQQESITKREEN-QEQPRNYSHHQLNRSSKHSQGLRDQGNQE 192
                        S     N + S+ ++  +    PR  SHH+      HS     Q    
Sbjct: 3231 -----------WSGSASRNHRGSVQEQSRHGSRHPR--SHHEDRAGHGHSADRSRQSGTR 3277

Query: 193  QDPNISNGE-----EEEEKEPGEVGTHNDNQ----ERKTELPREHANSKQEEDN------ 237
                 S G+     E+    PGE       Q     R + +PR  A+S   +        
Sbjct: 3278 HAETSSGGQAASSHEQARSSPGERHGSRHQQSADSSRHSGIPRGQASSAVRDSRHWGSSG 3337

Query: 238  ---TQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQETEWQ 294
               + S+   EESD  +     Q     Q +QE   + +      + S + +     + +
Sbjct: 3338 SQASDSEGHSEESDTQSVSGHGQAGPHQQSHQESARDRSGGRSGRSGSFLYQVSTHEQSE 3397

Query: 295  SQEGK----TGLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGVDDDGDDDGD--DG 348
            S  G+    TG    S+H++  + +   A     + +G  T R H         G   + 
Sbjct: 3398 SAHGRTRTSTGRRQGSHHEQARDSSRHSA-----SQEGQDTIRGHPGSSRRGRQGSHYEQ 3452

Query: 349  GTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIEEQREKVHENENIGTTEPGEHQEAK 408
              D   HS S      SQ   +A R QS +   +   ++ +  E    G+     H    
Sbjct: 3453 SVDRSGHSGSHHSHTTSQGRSDASRGQSGS---RSASRQTRNDEQSGDGSRHSWSHHHEA 3509

Query: 409  KAENSSNEEETSSEG 423
              +  S+    S +G
Sbjct: 3510 STQADSSRHSQSGQG 3524



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 77/398 (19%), Positives = 131/398 (32%), Gaps = 66/398 (16%)

Query: 50   EENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSV 109
            EE  ++ +  +    H  +  + + +  +    QS     S  Q   +    DS+GH   
Sbjct: 899  EEQSRDGSRHSGSRHHEASSHADISRHSQAGQGQSEGSRTSRRQGSSVSQDSDSEGH--- 955

Query: 110  NLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRN 169
                                     SE+++  +   S     + QE   +       PR 
Sbjct: 956  -------------------------SEDSERWSGSASRNHRGSAQE---QSRHGSRHPR- 986

Query: 170  YSHHQLNRSSKHSQGLRDQGNQEQDPNISNGE-----EEEEKEPGEVGTHNDNQ----ER 220
             SHH+      HS     Q         S G+     E+    PGE       Q     R
Sbjct: 987  -SHHEDRAGHGHSADSSRQSGTPHAETSSGGQAASSHEQARSSPGERHGSRHQQSADSSR 1045

Query: 221  KTELPREHANSKQEEDN---------TQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDN 271
             + +PR  A+S   +           + S+   EESD  +     Q+    Q +QE   +
Sbjct: 1046 HSGIPRRQASSAVRDSGHWGSSGSQASDSEGHSEESDTQSVSGHGQDGPHQQSHQESARD 1105

Query: 272  SNAEMEEENASNVNKHIQETEWQSQEGK----TGLEAISNHKETEEKTVSEALLMEPTDD 327
             +      + S + +     + +S  G+    TG    S+H++  + +   A     + +
Sbjct: 1106 WSGGRSGRSGSFIYQVSTHEQSESAHGRTRTSTGRRQGSHHEQARDSSRHSA-----SQE 1160

Query: 328  GNTTPRNHGVDDDGDDDGD--DGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIEE 385
            G  T R H     G   G   +   D   HS S      SQ   +A   QS +     + 
Sbjct: 1161 GQDTIRAHPGSRRGGRQGSHHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRQT 1220

Query: 386  QREKVHENENIGTTEPG-EHQEAKKAENSSNEEETSSE 422
            +++K       G+   G  H EA    +SS   +   E
Sbjct: 1221 RKDK---QSGDGSRHSGSRHHEAASWADSSRHSQVGQE 1255



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 85/408 (20%), Positives = 137/408 (33%), Gaps = 60/408 (14%)

Query: 56  TAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYAP 115
           T+    D SH ++   S  +      +       S S+      Q DS  H  V    + 
Sbjct: 550 TSQGRSDASHGQSGSRSASRQTRNEEQSGDGTRHSGSRHHEASSQADSSRHSQVGQGQSS 609

Query: 116 TEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREEN---QEQPRN--- 169
              T       S  Q   +S+++D  + G S   DS +      R  +   QEQ R+   
Sbjct: 610 GPRT-------SRNQGSSVSQDSD--SQGHSE--DSERWSGSASRNHHGSAQEQSRDGSR 658

Query: 170 --YSHHQLNRSSKHSQGLRDQGNQEQDPNISNGE-----EEEEKEPGEVGTHNDNQERKT 222
              SHH+      HS     +       N S+G+     E+     GE   H    + ++
Sbjct: 659 HPRSHHEDRAGHGHSADSSRKSGTRHTQNSSSGQAASSHEQARSSAGE--RHGSRHQLQS 716

Query: 223 ELPREHANSKQEEDN----------------TQSDDILEESDQPTQVSKMQEDEFDQGNQ 266
                H+ +   + +                T S+   E+SD  +     Q     Q +Q
Sbjct: 717 ADSSRHSGTGHGQASSAVRDSGHRGSSGSQATDSEGHSEDSDTQSVSGHGQAGHHQQSHQ 776

Query: 267 EQEDNSNAEMEEENAS---NVNKHIQETEWQSQEG-KTGLEAISNHKETEEKTVSEALLM 322
           E   + + E    + S    V+ H Q        G  TG+   S+H++  + +   A   
Sbjct: 777 ESARDRSGERSRRSGSFLYQVSTHKQSESSHGWTGPSTGVRQGSHHEQARDNSRHSA--- 833

Query: 323 EPTDDGNTTPRNHGVDDDGDDDGD--DGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYH 380
             + DG  T R H         G   +   D   HS S      SQ   +A R QS +  
Sbjct: 834 --SQDGQDTIRGHPGSSRRGRQGSHHEQSVDRSGHSGSHHSHTTSQGRSDASRGQSGS-- 889

Query: 381 LKIEEQREKVHENENIGTTEPG-EHQEAKKAENSSNEEET---SSEGN 424
            +   +  +  E    G+   G  H EA    + S   +     SEG+
Sbjct: 890 -RSASRTTRNEEQSRDGSRHSGSRHHEASSHADISRHSQAGQGQSEGS 936



 Score = 40.8 bits (94), Expect = 0.004
 Identities = 71/383 (18%), Positives = 129/383 (33%), Gaps = 36/383 (9%)

Query: 55   ETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYA 114
            + +   + +S H     S    +   HEQ+ +  + S+ + G        G      + +
Sbjct: 1768 QVSTHEQSESAHGRTGPSTGGRQRSRHEQARDSSRHSASQEGQDTIRGHPGSSRGGRQGS 1827

Query: 115  PTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQ 174
              E ++D             S+    ++ G S         S++++  N++Q  + S H 
Sbjct: 1828 HYEQSVDSSGHSGSHHSHTTSQERSDVSRGQSG------SRSVSRQTRNEKQSGDGSRHS 1881

Query: 175  LNR---------SSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQER-KTEL 224
             +R         SS+HSQ    QG Q   P  S  +     +  +   H+++ ER     
Sbjct: 1882 GSRHHEASSRADSSRHSQ--VGQG-QSSGPRTSRNQGSSVSQDSDSQGHSEDSERWSGSA 1938

Query: 225  PREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEM----EEEN 280
             R H  S  E+    S       +         +     G +  E +S  +     E+  
Sbjct: 1939 SRNHLGSAWEQSRDGSRHPGSHHEDRAGHGHSADSSRQSGTRHTESSSRGQAASSHEQAR 1998

Query: 281  ASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEPTD--DGNTTPRNHGVD 338
            +S   +H    + QS +        S H        S A+         G+    + G  
Sbjct: 1999 SSAGERHGSHHQLQSADS-------SRHSGIGHGQASSAVRDSGHRGYSGSQASDSEGHS 2051

Query: 339  DDGDDDGDDG-GTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIEEQREKVHENE--N 395
            +D D       G  GP H  S       Q+   + R+ S  Y +   EQ E  H     +
Sbjct: 2052 EDSDTQSVSAQGKAGP-HQQSHKESARGQSGESSGRSGSFLYQVSTHEQSESTHGQSAPS 2110

Query: 396  IGTTEPGEHQEAKKAENSSNEEE 418
             G  +   + +A+ +   S  +E
Sbjct: 2111 TGGRQGSHYDQAQDSSRHSASQE 2133



 Score = 39.7 bits (91), Expect = 0.009
 Identities = 51/282 (18%), Positives = 112/282 (39%), Gaps = 32/282 (11%)

Query: 159 KREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQ 218
           K+EEN+E  +  S  +   + K ++G R +  +E          E+++  G   TH + +
Sbjct: 114 KQEENKENRKRPSSLERRNNRKGNKG-RSKSPRETGGKRHESSSEKKERKGYSPTHREEE 172

Query: 219 ERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNA---- 274
             K      H +SK+E++ T++  + +   + ++  + +ED  ++G  + E+        
Sbjct: 173 YGKNH----HNSSKKEKNKTENTRLGDNRKRLSERLEEKEDN-EEGVYDYENTGRMTQKW 227

Query: 275 ----------EMEEENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEP 324
                      +++E     +  ++E +   +   +  ++ S    +  +  S+  L E 
Sbjct: 228 IQSGHIATYYTIQDEAYDTTDSLLEENKIYERSRSSDGKSSSQVNRSRHENTSQVPLQE- 286

Query: 325 TDDGNTTPRNHGVDDDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIE 384
               + T +  G     D D +    D  RHS S        A+   E+++  + H +  
Sbjct: 287 ----SRTRKRRGSRVSQDRDSEGHSEDSERHSGSASRNHHGSAW---EQSRDGSRHPRSH 339

Query: 385 EQREKVHENENIGTTEPGEHQEAKKAENSSNEEETSSEGNMR 426
           ++    H +    + + G     + AE SS  +  SS    R
Sbjct: 340 DEDRASHGHSADSSRQSG----TRHAETSSRGQTASSHEQAR 377



 Score = 37.7 bits (86), Expect = 0.034
 Identities = 65/384 (16%), Positives = 125/384 (32%), Gaps = 59/384 (15%)

Query: 46   RAEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQS--AEQGKSSSQELGLKDQE-- 101
            ++E+      T+      SHHK  + S   S  +  + +     G SS    G   ++  
Sbjct: 2423 QSESAHGRTGTSTGGRQGSHHKQARDSSRHSTSQEGQDTIHGHPGSSSGGRQGSHYEQLV 2482

Query: 102  DSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKRE 161
            D  GH   +  +  ++G  D     S  +                         S +++ 
Sbjct: 2483 DRSGHSGSHHSHTTSQGRSDASHGHSGSR-------------------------SASRQT 2517

Query: 162  ENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERK 221
             N EQ  + S H  +R  + S      G+ +     S G              +D+Q   
Sbjct: 2518 RNDEQSGDGSRHSGSRHHEASSRADSSGHSQVGQGQSEGPRTSRNWGSSFSQDSDSQGHS 2577

Query: 222  TELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENA 281
             +  R   ++ +    +  + + + S  P      QED    G+       +        
Sbjct: 2578 EDSERWSGSASRNHHGSAQEQLRDGSRHP---RSHQEDRAGHGHSADSSRQSG------- 2627

Query: 282  SNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSE--ALLMEPTDDGNTTPRNHGVDD 339
                +H Q +        +G +A S+H++          +   +  D    +   HG   
Sbjct: 2628 ---TRHTQTS--------SGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQAS 2676

Query: 340  DGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIEEQREKVHENENIGTT 399
                D    G  G +  ASD     ++   E    QS++ H +    ++   E+    + 
Sbjct: 2677 SAVRDSGHRGYSGSQ--ASD-----NEGHSEDSDTQSVSAHGQAGSHQQSHQESARGRSG 2729

Query: 400  EPGEHQEAKKAENSSNEEETSSEG 423
            E   H  +   + S++E+  SS G
Sbjct: 2730 ETSGHSGSFLYQVSTHEQSESSHG 2753



 Score = 36.6 bits (83), Expect = 0.076
 Identities = 77/420 (18%), Positives = 146/420 (34%), Gaps = 47/420 (11%)

Query: 55   ETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSD-GHLSVN-LE 112
            +T+   +  S H+  +SS  +     H+QSA+  + S    G       D GH   +  +
Sbjct: 2956 QTSSGGQAASSHEQARSSAGERHGSHHQQSADSSRHSGIGHGQASSAVRDSGHRGYSGSQ 3015

Query: 113  YAPTEG---TLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRN 169
             +  EG     D +   +  Q     ++    A G S  T S    S   +    EQ  +
Sbjct: 3016 ASDNEGHSEDSDTQSVSAHGQAGSHQQSHQESARGRSGET-SGHSGSFLYQVSTHEQSES 3074

Query: 170  YSHHQLNRSSKHSQGLRDQGNQEQDPNISN--GEEEEEKEPGEV--GTHNDNQERKTELP 225
             SH     S++  QG R +  Q+   + ++  G++     PG    G    + E   +  
Sbjct: 3075 -SHGWTGPSTRGRQGSRHEQAQDSSRHSASQYGQDTIRGHPGSSRGGRQGYHHEHSVD-S 3132

Query: 226  REHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVN 285
              H+ S      +Q           ++ +       +Q       + +   E    ++++
Sbjct: 3133 SGHSGSHHSHTTSQGRSDASRGQSGSRSASRTTRNEEQSGDSSRHSVSRHHEASTHADIS 3192

Query: 286  KHIQETEWQSQEGKTGLEAISN---------HKETEEKTVSEA------LLMEPTDDGNT 330
            +H Q  + QS+  +      S+         H E  E+    A       + E +  G+ 
Sbjct: 3193 RHSQAVQGQSEGSRRSRRQGSSVSQDSDSEGHSEDSERWSGSASRNHRGSVQEQSRHGSR 3252

Query: 331  TPRNHGVDDDG-DDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIEEQREK 389
             PR+H  D  G     D     G RH+ +            +   Q+ + H +      +
Sbjct: 3253 HPRSHHEDRAGHGHSADRSRQSGTRHAET------------SSGGQAASSHEQARSSPGE 3300

Query: 390  VHENENIGTTEPGEHQEAKKAENSSNEEETSSEGNMRVHAVDSCMSFQCKRGHICKADQQ 449
             H + +  + +   H    + + SS   ++   G+    A DS        GH  ++D Q
Sbjct: 3301 RHGSRHQQSADSSRHSGIPRGQASSAVRDSRHWGSSGSQASDS-------EGHSEESDTQ 3353



 Score = 36.2 bits (82), Expect = 0.100
 Identities = 50/271 (18%), Positives = 97/271 (35%), Gaps = 34/271 (12%)

Query: 55   ETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNLEYA 114
            + +   + +S H     S    +   HEQ+ +  + S+ + G        G      + +
Sbjct: 3713 QVSTHEQSESAHGRAGPSTGGRQGSRHEQARDSSRHSASQEGQDTIRGHPGSRRGGRQGS 3772

Query: 115  PTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQ 174
              E ++D             S+     + G S         S ++   N+EQ  + S H 
Sbjct: 3773 YHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSG------SRSASRETRNEEQSGDGSRHS 3826

Query: 175  LNR---------SSKHSQG----------LRDQG---NQEQDPNISNGEEEEEKEPGEVG 212
             +R         SS+HSQ            R QG   +Q+ D      + E   E     
Sbjct: 3827 GSRHHEASTQADSSRHSQSGQGESAGSRRSRRQGSSVSQDSDSEAYPEDSERRSESASRN 3886

Query: 213  THNDNQERKTELPREHANSKQE-EDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDN 271
             H  ++E+  +  R   +S ++   + QS  +  +S      +  +   F   +Q+   +
Sbjct: 3887 HHGSSREQSRDGSRHPGSSHRDTASHVQSSPVQSDSS-----TAKEHGHFSSLSQDSAYH 3941

Query: 272  SNAEMEEENASNVNKHIQETEWQSQEGKTGL 302
            S  +      S+ + H Q    + Q+G++GL
Sbjct: 3942 SGIQSRGSPHSSSSYHYQSEGTERQKGQSGL 3972



 Score = 35.4 bits (80), Expect = 0.17
 Identities = 57/323 (17%), Positives = 114/323 (35%), Gaps = 37/323 (11%)

Query: 154  QESITKREENQEQPRNYSHHQLN-RSSKH---------SQGLRDQGNQEQDPNISNGEEE 203
            Q++I     ++   R  SHH+ +   S H         SQG  D  + +     ++ +  
Sbjct: 1162 QDTIRAHPGSRRGGRQGSHHEQSVDRSGHSGSHHSHTTSQGRSDASHGQSGSRSASRQTR 1221

Query: 204  EEKEPGEVGTHNDNQERKTELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQ 263
            ++K+ G+   H+ ++         H  +    D+++   + +E    ++ S+ Q     Q
Sbjct: 1222 KDKQSGDGSRHSGSR---------HHEAASWADSSRHSQVGQEQSSGSRTSRHQGSSVSQ 1272

Query: 264  GNQEQEDNSNAEMEEENASNVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLME 323
             +  +  + ++E    +AS  N H    E    + + G      H+E        A    
Sbjct: 1273 DSDSERHSDDSERLSGSASR-NHHGSSRE----QSRDGSRHPGFHQEDRASHGHSADSSR 1327

Query: 324  PTDDGNTTPRNHG--VDDDGDDDGDDGGTDGPRHSASDD--------YFIPSQAFLEAER 373
             +   +T   +HG  V          G   G RH  S D        +   S A  ++  
Sbjct: 1328 QSGTHHTESSSHGQAVSSHEQARSSPGERHGSRHQQSADSSRHSGIGHRQASSAVRDSGH 1387

Query: 374  AQSIAYHLKIEEQREKVHENENIGT-TEPGEHQEAKKAENSSNEEETSSEGNMRVHAVDS 432
              S    +   E   +  + +++    + G HQ++ K        E+S      ++ V S
Sbjct: 1388 RGSSGSQVTNSEGHSEDSDTQSVSAHGQAGPHQQSHKESARGQSGESSGRSRSFLYQVSS 1447

Query: 433  CMSFQCKRGHICKA--DQQGKPH 453
                +   G    +   +QG  H
Sbjct: 1448 HEQSESTHGQTAPSTGGRQGSRH 1470



 Score = 31.6 bits (70), Expect = 2.5
 Identities = 36/193 (18%), Positives = 71/193 (36%), Gaps = 12/193 (6%)

Query: 25   SDHSKPTAETVAPDNTAIPSLRAEAEENEKETAVSTEDDSHHKAEKSSVLKSKEES--HE 82
            S HS  T++  +  +      R+ + E   E    + D S H   +     ++ +S  H 
Sbjct: 3786 SHHSHTTSQGRSDASHGQSGSRSASRETRNEE--QSGDGSRHSGSRHHEASTQADSSRHS 3843

Query: 83   QSAE---QGKSSSQELGLKDQEDSDGHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTD 139
            QS +    G   S+  G    +DSD           +E         S  Q +  S +  
Sbjct: 3844 QSGQGESAGSRRSRRQGSSVSQDSDSEAYPEDSERRSESASRNHHGSSREQSRDGSRH-- 3901

Query: 140  FLAPGVSSFTDSNQQESITKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISN 199
               PG S    ++  +S   + ++     +     L++ S +  G++ +G+     +   
Sbjct: 3902 ---PGSSHRDTASHVQSSPVQSDSSTAKEHGHFSSLSQDSAYHSGIQSRGSPHSSSSYHY 3958

Query: 200  GEEEEEKEPGEVG 212
              E  E++ G+ G
Sbjct: 3959 QSEGTERQKGQSG 3971


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 55.8 bits (133), Expect = 1e-07
 Identities = 69/380 (18%), Positives = 151/380 (39%), Gaps = 25/380 (6%)

Query: 45  LRAEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSD 104
           LR + E+ +++     E +   + ++  + + +E   EQ  +  +   QE  ++DQE+  
Sbjct: 343 LREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMRE---QEQKMRDQEERM 399

Query: 105 GHLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREEN- 163
                 L     E  +  +E M E  EK   E                +QE  T+ +E  
Sbjct: 400 WEQDERLR--EKEERMREQEKMWEQVEKMREEKK------------MQEQEKKTRDQEEK 445

Query: 164 -QEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKT 222
            QE+ R     +  R  + +   +++  Q+Q+ N+   EE+E ++           E++ 
Sbjct: 446 MQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEK 505

Query: 223 ELPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENAS 282
              +E    +QEE     +++  +  +  +  KM+E E     QE++     +   +   
Sbjct: 506 MQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEE 565

Query: 283 NVNKHIQETEWQSQEGKTGLEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHGVDDDGD 342
            + K  QE E ++ + +  +      +E E+K   E  +M   ++           ++  
Sbjct: 566 RMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEE------KMQEQEEKM 619

Query: 343 DDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIEEQREKVHENENIGTTEPG 402
            + ++   +        +  +  Q     E+ + +    ++ EQ+EK+ E+E +   E  
Sbjct: 620 QEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKM 679

Query: 403 EHQEAKKAENSSNEEETSSE 422
           + QE K  E    E++T  +
Sbjct: 680 QEQEEKIWEQEKMEKKTQEQ 699



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 68/390 (17%), Positives = 144/390 (36%), Gaps = 24/390 (6%)

Query: 50  EENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDGH--- 106
           +E EK+T    E     +  +    K +EE      ++ K   QE  + +QE+ +     
Sbjct: 433 QEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQR 492

Query: 107 LSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQ 166
           L    E    +  +  +E+    QE+K+ +  +        +     +E   +  E +E+
Sbjct: 493 LPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEK 552

Query: 167 PRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPR 226
            R+      ++  +  +  ++Q  +  D      +EE+ +E   +         + E+ R
Sbjct: 553 MRDQEQKMWDQEERMEKKTQEQEKKTWD------QEEKMREEERMREREKKMREEEEMMR 606

Query: 227 EHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQE---------DNSNAEME 277
           E     QE++    +   +E     Q  KMQE E     QE++         +      +
Sbjct: 607 EQEEKMQEQEEKMQE---QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQ 663

Query: 278 EENASNVNKHIQETEWQSQEGKTG-LEAISNHKETEEKTVSEALLMEPTDDGNTTPRNHG 336
           +E      K  ++ + Q QE K    E +    + +EK   +   M   +      +   
Sbjct: 664 KEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMR 723

Query: 337 VDDDGDDDGDDGGTDGPRHSASDDYFIPSQAFLEAERAQSIAYHLKIEEQREKVHENENI 396
            +++   + ++   +        +  +  Q     E+ + +    ++ EQ+EK+ E+E +
Sbjct: 724 EEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKM 783

Query: 397 GTTEPGEHQEAKKAENSSNEEETSSEGNMR 426
              E    QE K  +    E+    E  MR
Sbjct: 784 QEQEKIWEQEEKMRD--QEEKMRGQEEKMR 811



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 57/274 (20%), Positives = 115/274 (41%), Gaps = 42/274 (15%)

Query: 46  RAEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDG 105
           R E E  E+E  +  +++   + E+    + +E+  +   ++ K   QE  L++QE    
Sbjct: 276 RQEEELREQEKKIRKQEEKMWRQEE----RLREQEGKMREQEEKMWRQEKRLREQEKELR 331

Query: 106 HLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQE 165
                L     +  L  +E+  + QE+K+ E                Q+E + ++EE   
Sbjct: 332 EQEKELR---EQKELREQEEQMQEQEEKMWE----------------QEEKMREQEEKMW 372

Query: 166 QPRNYSHHQLNRSSKHSQGLRDQGNQ--EQDPNISNGEEEEEKEPGEVGTHNDNQERKTE 223
           +       Q  +  +  Q +RDQ  +  EQD  +   +EE  +E  ++    +    + +
Sbjct: 373 RQEERLWEQEKQMREQEQKMRDQEERMWEQDERLRE-KEERMREQEKMWEQVEKMREEKK 431

Query: 224 LPREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASN 283
           +  +   ++ +E+  Q ++ + E ++  +  +    E ++  Q+QE+N    M E+    
Sbjct: 432 MQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEEN----MWEQ---- 483

Query: 284 VNKHIQETEWQSQ---EGKTGLEAISNHKETEEK 314
                +E EWQ Q   E K  L      +E EEK
Sbjct: 484 -----EEKEWQQQRLPEQKEKLWEQEKMQEQEEK 512



 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 61/269 (22%), Positives = 120/269 (44%), Gaps = 17/269 (6%)

Query: 53  EKETAVSTEDDSHHKAEKSSVLKSKE-ESHEQSAEQGKSSSQELGLKDQEDSDGHLSVNL 111
           E + A+S     H KA++     +KE ++      +   +++EL  K+ E     L   L
Sbjct: 180 ELQRALSAVSTRHKKADRYIEELTKERDALSLELYRNTITNEELKKKNAE-----LQEKL 234

Query: 112 EYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQEQPRNYS 171
             A +E + +I+ ++ E + K   E   FL P V   T++ Q+E   + EE +EQ +   
Sbjct: 235 PLAESEKS-EIQLNVKELKRKL--ERAKFLLPQVQ--TNTLQEEMWRQEEELREQEKKI- 288

Query: 172 HHQLNRSSKHSQGLRDQGNQ--EQDPNISNGEEEEEKEPGEVGTHNDNQERKTELPREHA 229
             Q  +  +  + LR+Q  +  EQ+  +   E+   ++  E+         + EL RE  
Sbjct: 289 RKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKEL-REQE 347

Query: 230 NSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQEQEDNSNAEMEEENASNVNKHIQ 289
              QE++    +   +  +Q  ++ + +E  ++Q  Q +E       +EE     ++ ++
Sbjct: 348 EQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDERLR 407

Query: 290 ETEWQSQEGKTGLEAISNHKETEEKTVSE 318
           E E + +E +   E +   K  EEK + E
Sbjct: 408 EKEERMREQEKMWEQV--EKMREEKKMQE 434



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 58/285 (20%), Positives = 116/285 (40%), Gaps = 24/285 (8%)

Query: 48  EAEEN--EKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQG-KSSSQELGLKDQEDSD 104
           E EE   E+E  +  +++   + +K    +   E  +Q  EQ  K   QE  + DQE+  
Sbjct: 508 EQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERM 567

Query: 105 GHLSVNLEYAPTEGTLDIKEDMSEPQ-----EKKLSENTDFLAPGVSSFTDSNQQESITK 159
              +   E    + T D +E M E +     EKK+ E  + +        +  Q+E + +
Sbjct: 568 EKKTQEQE----KKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQE--QEEKMQE 621

Query: 160 REENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTHNDNQE 219
           +EE   +       Q  +  +  + + +Q  +  +      ++E+  E  ++      QE
Sbjct: 622 QEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQE 681

Query: 220 RKTEL----PREHANSKQEEDNTQSDDILEESDQPTQVSKMQEDEFDQGNQE----QEDN 271
           ++ ++      E    +QE+     + + EE     +  KM+E+E     QE    +++ 
Sbjct: 682 QEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEE 741

Query: 272 SNAEMEEENASNVNKHIQETE--WQSQEGKTGLEAISNHKETEEK 314
              E EEE      K  ++ E  W+ Q      E +  H++ +E+
Sbjct: 742 KMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQ 786



 Score = 44.7 bits (104), Expect = 3e-04
 Identities = 56/266 (21%), Positives = 107/266 (40%), Gaps = 24/266 (9%)

Query: 48  EAEEN--EKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSDG 105
           E EE   E+E  +  +++   + ++    K K   HE+  EQ K   QE  + +QE  + 
Sbjct: 635 EQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEK 694

Query: 106 HLSVNLEYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQESITKREENQE 165
                 +    +  +  +E M E +EKK+ E  + +           Q+E + ++EE  +
Sbjct: 695 KTQEQEKKTWDQEKMREEESMRE-REKKMREEEEMMR---------EQEEKMQEQEEKMQ 744

Query: 166 QPRNYSHHQLNRSSKHSQGLRDQGN-QEQDPNISNGEEEEEKEP-GEVGTHNDNQERKTE 223
           +       Q  +  +  + + +Q    EQ   +   E+ +E+E   E      +QE K  
Sbjct: 745 EQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMR 804

Query: 224 LPREHANSKQEEDNTQSDDIL--------EESDQPTQVSKM--QEDEFDQGNQEQEDNSN 273
              E    ++E+   Q + +         +E     Q  KM  QE++ ++  Q QE+   
Sbjct: 805 GQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMR 864

Query: 274 AEMEEENASNVNKHIQETEWQSQEGK 299
            + E+          QE + + QE K
Sbjct: 865 EQEEKMRGQEEKMREQEEKMRGQEEK 890



 Score = 37.0 bits (84), Expect = 0.058
 Identities = 39/242 (16%), Positives = 91/242 (37%), Gaps = 15/242 (6%)

Query: 45  LRAEAEENEKETAVSTEDDSHHKAEKSSVLKSKEESHEQSAEQGKSSSQELGLKDQEDSD 104
           +R E    E+E  +  E++   + E+    K +E+  +   ++ K   QE  +++QE+  
Sbjct: 585 MREEERMREREKKMREEEEMMREQEE----KMQEQEEKMQEQEEKMWEQEEKMQEQEEKM 640

Query: 105 GHLSVNL----------EYAPTEGTLDIKEDMSEPQEKKLSENTDFLAPGVSSFTDSNQQ 154
                 +          +  P +     + +  + QEK   +                Q+
Sbjct: 641 WEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQE 700

Query: 155 ESITKREENQEQPRNYSHHQLNRSSKHSQGLRDQGNQEQDPNISNGEEEEEKEPGEVGTH 214
           +    +E+ +E+       +  R  +     +++  QEQ+  +   EEE  ++  ++   
Sbjct: 701 KKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQ 760

Query: 215 NDNQERKTELPREHANSKQEEDNTQSDDILEESDQ-PTQVSKMQEDEFDQGNQEQEDNSN 273
            +    +  LP +     + E   + + I E+ ++   Q  KM+  E     QE++    
Sbjct: 761 EEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQ 820

Query: 274 AE 275
            E
Sbjct: 821 EE 822


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.308    0.126    0.364 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,401,366
Number of Sequences: 37866
Number of extensions: 1454061
Number of successful extensions: 17119
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 286
Number of HSP's successfully gapped in prelim test: 980
Number of HSP's that attempted gapping in prelim test: 7553
Number of HSP's gapped (non-prelim): 5361
length of query: 664
length of database: 18,247,518
effective HSP length: 109
effective length of query: 555
effective length of database: 14,120,124
effective search space: 7836668820
effective search space used: 7836668820
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.