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Search of human proteins with 190014588
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|190014588 PC4 and SFRS1 interacting protein 1 isoform 2
[Homo sapiens]
(530 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|190014588 PC4 and SFRS1 interacting protein 1 isoform 2 [Homo... 1058 0.0
gi|19923653 PC4 and SFRS1 interacting protein 1 isoform 2 [Homo ... 1058 0.0
gi|190014586 PC4 and SFRS1 interacting protein 1 isoform 1 [Homo... 660 0.0
gi|14249158 hepatoma-derived growth factor-related protein 2 iso... 208 9e-54
gi|48255931 hepatoma-derived growth factor-related protein 2 iso... 207 2e-53
gi|7705320 hepatoma-derived growth factor, related protein 3 [Ho... 187 2e-47
gi|4758516 hepatoma-derived growth factor isoform a [Homo sapiens] 185 1e-46
gi|186928819 hepatoma-derived growth factor isoform b [Homo sapi... 145 1e-34
gi|186928821 hepatoma-derived growth factor isoform c [Homo sapi... 144 3e-34
gi|110681712 hepatoma derived growth factor-like 1 [Homo sapiens] 135 9e-32
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 76 9e-14
gi|13540523 nucleosomal binding protein 1 [Homo sapiens] 72 1e-12
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 72 1e-12
gi|87299628 biorientation of chromosomes in cell division 1-like... 72 1e-12
gi|4557509 cylicin 2 [Homo sapiens] 72 2e-12
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 70 6e-12
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 69 1e-11
gi|239508778 PREDICTED: hypothetical protein, partial [Homo sapi... 69 1e-11
gi|153945728 microtubule-associated protein 1B [Homo sapiens] 68 2e-11
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 68 2e-11
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 67 5e-11
gi|239757964 PREDICTED: hypothetical protein [Homo sapiens] 66 9e-11
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 65 2e-10
gi|104526627 triadin [Homo sapiens] 65 2e-10
gi|120953300 leucine-rich repeats and IQ motif containing 1 isof... 64 4e-10
gi|120953243 leucine-rich repeats and IQ motif containing 1 isof... 64 4e-10
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens] 64 4e-10
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 62 1e-09
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 62 1e-09
gi|239747174 PREDICTED: hypothetical protein XP_002343931, parti... 62 2e-09
>gi|190014588 PC4 and SFRS1 interacting protein 1 isoform 2 [Homo
sapiens]
Length = 530
Score = 1058 bits (2736), Expect = 0.0
Identities = 530/530 (100%), Positives = 530/530 (100%)
Query: 1 MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFP 60
MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFP
Sbjct: 1 MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFP 60
Query: 61 YSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKE 120
YSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKE
Sbjct: 61 YSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKE 120
Query: 121 DTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKR 180
DTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKR
Sbjct: 121 DTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKR 180
Query: 181 GRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKE 240
GRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKE
Sbjct: 181 GRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKE 240
Query: 241 EDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRR 300
EDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRR
Sbjct: 241 EDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRR 300
Query: 301 NMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIK 360
NMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIK
Sbjct: 301 NMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIK 360
Query: 361 NSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLY 420
NSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLY
Sbjct: 361 NSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLY 420
Query: 421 NKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNG 480
NKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNG
Sbjct: 421 NKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNG 480
Query: 481 GSDAQDGNQPQHNGESNEDSKDNHEASTKKKPSSEERETEISLKDSTLDN 530
GSDAQDGNQPQHNGESNEDSKDNHEASTKKKPSSEERETEISLKDSTLDN
Sbjct: 481 GSDAQDGNQPQHNGESNEDSKDNHEASTKKKPSSEERETEISLKDSTLDN 530
>gi|19923653 PC4 and SFRS1 interacting protein 1 isoform 2 [Homo
sapiens]
Length = 530
Score = 1058 bits (2736), Expect = 0.0
Identities = 530/530 (100%), Positives = 530/530 (100%)
Query: 1 MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFP 60
MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFP
Sbjct: 1 MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFP 60
Query: 61 YSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKE 120
YSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKE
Sbjct: 61 YSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKE 120
Query: 121 DTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKR 180
DTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKR
Sbjct: 121 DTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKR 180
Query: 181 GRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKE 240
GRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKE
Sbjct: 181 GRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKE 240
Query: 241 EDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRR 300
EDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRR
Sbjct: 241 EDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRR 300
Query: 301 NMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIK 360
NMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIK
Sbjct: 301 NMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIK 360
Query: 361 NSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLY 420
NSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLY
Sbjct: 361 NSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLY 420
Query: 421 NKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNG 480
NKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNG
Sbjct: 421 NKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNG 480
Query: 481 GSDAQDGNQPQHNGESNEDSKDNHEASTKKKPSSEERETEISLKDSTLDN 530
GSDAQDGNQPQHNGESNEDSKDNHEASTKKKPSSEERETEISLKDSTLDN
Sbjct: 481 GSDAQDGNQPQHNGESNEDSKDNHEASTKKKPSSEERETEISLKDSTLDN 530
>gi|190014586 PC4 and SFRS1 interacting protein 1 isoform 1 [Homo
sapiens]
Length = 333
Score = 660 bits (1704), Expect = 0.0
Identities = 326/327 (99%), Positives = 326/327 (99%)
Query: 1 MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFP 60
MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFP
Sbjct: 1 MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFP 60
Query: 61 YSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKE 120
YSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKE
Sbjct: 61 YSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKE 120
Query: 121 DTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKR 180
DTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKR
Sbjct: 121 DTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKR 180
Query: 181 GRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKE 240
GRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKE
Sbjct: 181 GRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKE 240
Query: 241 EDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRR 300
EDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRR
Sbjct: 241 EDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRR 300
Query: 301 NMLKGQHEKEAADRKRKQEEQMETEQQ 327
NMLKGQHEKEAADRKRKQEEQMETE Q
Sbjct: 301 NMLKGQHEKEAADRKRKQEEQMETEHQ 327
>gi|14249158 hepatoma-derived growth factor-related protein 2
isoform 2 [Homo sapiens]
Length = 670
Score = 208 bits (530), Expect = 9e-54
Identities = 181/679 (26%), Positives = 288/679 (42%), Gaps = 169/679 (24%)
Query: 1 MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFP 60
M FKPGDL+FAKMKGYPHWPAR+D++ DGAVKPP NK PIFFFGTHETAFLGPKD+FP
Sbjct: 1 MPHAFKPGDLVFAKMKGYPHWPARIDDIADGAVKPPPNKYPIFFFGTHETAFLGPKDLFP 60
Query: 61 YSENKEKYGKPNKRKGFNEGLWEIDNNPKVKF------SSQQAATKQSNAS--SDVEVEE 112
Y + K+KYGKPNKRKGFNEGLWEI NNP + SS + ++N + SD + ++
Sbjct: 61 YDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEANPADGSDADEDD 120
Query: 113 KETSV--------------SKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAE-KQV 157
++ V + D+D ++ + N + + ++R RK ++ Q
Sbjct: 121 EDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQA 180
Query: 158 ETEEAGVVTTATASVNLKVSPKRGRP---AATEVKIPKPRGRPKMVKQPCPSESDIITEE 214
+ + ++S + K S + P AA P G K K P S+SD +
Sbjct: 181 SVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADS 240
Query: 215 D-------------KSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKR 261
D S KK G+K +KP +P ++ K E
Sbjct: 241 DGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPE----- 295
Query: 262 KNLAKTGVTSTSDSEEEGDDQEGEKKRKG---GRNFQTAHRRNMLK-----GQHEKEAAD 313
+ +S+SDS+ + D+ E KR+ R + RR + + EKE +
Sbjct: 296 ----RPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKE 351
Query: 314 RKRKQ-------------------------------------------EEQMETEQQNKD 330
R+R++ E + E E++ K
Sbjct: 352 RRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKK 411
Query: 331 EGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLK----------IDNLDVNRCIEALDEL 380
KKP+ E R+ + R+ E K K + ++R +E E
Sbjct: 412 SAKKPQSSSTEPARKPGQKEK--RVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEKKKE- 468
Query: 381 ASLQVTMQQAQKHTEM--------------ITTLKKIRRFKVSQVIMEKST--------- 417
S++ +Q+ H+E+ + L+++ +V+ I++K+T
Sbjct: 469 PSVEEKLQKL--HSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKI 526
Query: 418 --------------MLYNKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKD-QGKK 462
+Y + K+ L + ++V Q +NK+ E+ + EE ++ G++
Sbjct: 527 RRYKANKDVMEKAAEVYTRLKSRVLGPKIEAV--QKVNKAGMEKEKAEEKLAGEELAGEE 584
Query: 463 GPNKKLEKEQTG--SKTLNGGSDAQDGNQPQHNGE-------------SNEDSKDNHEAS 507
P +K E + + S +NG + +Q G + S+ED D E
Sbjct: 585 APQEKAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEEGPRCGSSEDLHDVREGP 644
Query: 508 TKKKPSSEERETEISLKDS 526
+P S+ +E E + DS
Sbjct: 645 DLDRPGSDRQERERARGDS 663
>gi|48255931 hepatoma-derived growth factor-related protein 2
isoform 1 [Homo sapiens]
Length = 671
Score = 207 bits (527), Expect = 2e-53
Identities = 181/633 (28%), Positives = 280/633 (44%), Gaps = 126/633 (19%)
Query: 1 MTRDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFP 60
M FKPGDL+FAKMKGYPHWPAR+D++ DGAVKPP NK PIFFFGTHETAFLGPKD+FP
Sbjct: 1 MPHAFKPGDLVFAKMKGYPHWPARIDDIADGAVKPPPNKYPIFFFGTHETAFLGPKDLFP 60
Query: 61 YSENKEKYGKPNKRKGFNEGLWEIDNNPKVKF------SSQQAATKQSNAS--SDVEVEE 112
Y + K+KYGKPNKRKGFNEGLWEI NNP + SS + ++N + SD + ++
Sbjct: 61 YDKCKDKYGKPNKRKGFNEGLWEIQNNPHASYSAPPPVSSSDSEAPEANPADGSDADEDD 120
Query: 113 KETSV--------------SKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAE-KQV 157
++ V + D+D ++ + N + + ++R RK ++ Q
Sbjct: 121 EDRGVMAVTAVTATAASDRMESDSDSDKSSDNSGLKRKTPALKMSVSKRARKASSDLDQA 180
Query: 158 ETEEAGVVTTATASVNLKVSPKRGRP---AATEVKIPKPRGRPKMVKQPCPSESDIITEE 214
+ + ++S + K S + P AA P G K K P S+SD +
Sbjct: 181 SVSPSEEENSESSSESEKTSDQDFTPEKKAAVRAPRRGPLGGRKKKKAPSASDSDSKADS 240
Query: 215 D-------------KSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKR 261
D S KK G+K +KP +P ++ K E
Sbjct: 241 DGAKPEPVAMARSASSSSSSSSSSDSDVSVKKPPRGRKPAEKPLPKPRGRKPKPE----- 295
Query: 262 KNLAKTGVTSTSDSEEEGDDQEGEKKRKG---GRNFQTAHRRNMLK-----GQHEKEAAD 313
+ +S+SDS+ + D+ E KR+ R + RR + + EKE +
Sbjct: 296 ----RPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARRRREQEEELRRLREQEKEEKE 351
Query: 314 RKRKQEEQMETEQ-------QNKDEGKKPEVKKVEKKR----ETSMDSRLQ-RIHAEIKN 361
R+R++ ++ E E+ E +P K+ K R +S DS + + E K
Sbjct: 352 RRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGRGPPSSSDSEPEAELEREAKK 411
Query: 362 SLKIDNL----------DVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQV 411
S K + + ++ + V +++ +K +E + +K+ + K
Sbjct: 412 SAKKPQSSSTEPARKPGQKEKRVRPEEKQQAKPVKVERTRKRSEGFSMDRKVEK-KKEPS 470
Query: 412 IMEKSTMLYNKFKNMFLVGEGD--------------SVITQVLNKS---LAEQRQHEEAN 454
+ EK L+++ K V D V +Q+L K+ +A ++
Sbjct: 471 VEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVTSQILQKNTDVVATLKKIRRYK 530
Query: 455 KTKDQGKK-------------GP--------NKK-LEKEQTGSKTLNGGSDAQDGNQPQH 492
KD +K GP NK +EKE+ K G + PQ
Sbjct: 531 ANKDVMEKAAEVYTRLKSRVLGPKIEAVQKVNKAGMEKEKAEEKL--AGEELAGEEAPQE 588
Query: 493 NGESNEDSKD-----NHEASTKKKPSSEERETE 520
E ++ S D N EA+++K S+E++E E
Sbjct: 589 KAE-DKPSTDLSAPVNGEATSQKGESAEDKEHE 620
Score = 174 bits (440), Expect = 2e-43
Identities = 152/517 (29%), Positives = 263/517 (50%), Gaps = 90/517 (17%)
Query: 88 PKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAA-- 145
P +K S + A K ASSD++ + SVS + ++ E +S + T D T K A
Sbjct: 160 PALKMSVSKRARK---ASSDLD----QASVSPSEEENSESSSESEKTSDQDFTPEKKAAV 212
Query: 146 ---RRG-----RKRKAEKQVETEE-----------------AGVVTTATASVNLKVS--- 177
RRG +K+KA +++ A +++++S + VS
Sbjct: 213 RAPRRGPLGGRKKKKAPSASDSDSKADSDGAKPEPVAMARSASSSSSSSSSSDSDVSVKK 272
Query: 178 PKRGRPAATEVKIPKPRGR-PKMVKQPCPSESDIITEE----------DKSKKKGQEEKQ 226
P RGR A E +PKPRGR PK + P S SD ++E D+++++ E ++
Sbjct: 273 PPRGRKPA-EKPLPKPRGRKPKPERPPSSSSSDSDSDEVDRISEWKRRDEARRRELEARR 331
Query: 227 PKKQP---KKDEEGQKEEDKPRKE----------------PDKKEGKKEVESKRKNLAKT 267
++Q ++ E +KEE + R+E + +E + V+ + +
Sbjct: 332 RREQEEELRRLREQEKEEKERRRERADRGEAERGSGGSSGDELREDDEPVKKRGRKGRGR 391
Query: 268 GVTSTSDSEEEGD-DQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQ 326
G S+SDSE E + ++E +K K ++ T R GQ EK +++Q + ++ E+
Sbjct: 392 GPPSSSDSEPEAELEREAKKSAKKPQSSSTEPARK--PGQKEKRVRPEEKQQAKPVKVER 449
Query: 327 QNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVT 386
K +KVEKK+E S++ +LQ++H+EIK +LK+D+ DV RC+ AL+EL +LQVT
Sbjct: 450 TRKRSEGFSMDRKVEKKKEPSVEEKLQKLHSEIKFALKVDSPDVKRCLNALEELGTLQVT 509
Query: 387 MQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAE 446
Q QK+T+++ TLKKIRR+K ++ +MEK+ +Y + K+ L + ++V Q +NK+ E
Sbjct: 510 SQILQKNTDVVATLKKIRRYKANKDVMEKAAEVYTRLKSRVLGPKIEAV--QKVNKAGME 567
Query: 447 QRQHEEANKTKD-QGKKGPNKKLEKEQTG--SKTLNGGSDAQDG----NQPQHNGESNED 499
+ + EE ++ G++ P +K E + + S +NG + +Q G ++ G +E+
Sbjct: 568 KEKAEEKLAGEELAGEEAPQEKAEDKPSTDLSAPVNGEATSQKGESAEDKEHEEGRDSEE 627
Query: 500 ------SKDNH----EASTKKKPSSEERETEISLKDS 526
S+D H E +P S+ +E E + DS
Sbjct: 628 GPRCGSSEDLHDSVREGPDLDRPGSDRQERERARGDS 664
>gi|7705320 hepatoma-derived growth factor, related protein 3 [Homo
sapiens]
Length = 203
Score = 187 bits (476), Expect = 2e-47
Identities = 89/160 (55%), Positives = 116/160 (72%), Gaps = 7/160 (4%)
Query: 3 RDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFPYS 62
R++K GDL+FAKMKGYPHWPAR+DE+P+GAVKPP NK PIFFFGTHETAFLGPKD+FPY
Sbjct: 7 REYKAGDLVFAKMKGYPHWPARIDELPEGAVKPPANKYPIFFFGTHETAFLGPKDLFPYK 66
Query: 63 ENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDT 122
E K+K+GK NKRKGFNEGLWEI+NNP VKF+ QA +QS++ ++ E + S+E+
Sbjct: 67 EYKDKFGKSNKRKGFNEGLWEIENNPGVKFTGYQAIQQQSSSETEGEGGNTADASSEEEG 126
Query: 123 DHEE-----KASNEDV--TKAVDITTPKAARRGRKRKAEK 155
D E K NE + T+ K++++ RK ++
Sbjct: 127 DRVEEDGKGKRKNEKAGSKRKKSYTSKKSSKQSRKSPGDE 166
Score = 32.0 bits (71), Expect = 1.4
Identities = 22/94 (23%), Positives = 44/94 (46%), Gaps = 19/94 (20%)
Query: 258 ESKRKNLAKTGVTSTSDSEEEGD--DQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRK 315
+S + + G T+ + SEEEGD +++G+ KRK +EK + RK
Sbjct: 105 QSSSETEGEGGNTADASSEEEGDRVEEDGKGKRK-----------------NEKAGSKRK 147
Query: 316 RKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMD 349
+ + ++Q K G + + E++ ++S +
Sbjct: 148 KSYTSKKSSKQSRKSPGDEDDKDCKEEENKSSSE 181
Score = 29.6 bits (65), Expect = 7.1
Identities = 19/75 (25%), Positives = 37/75 (49%), Gaps = 11/75 (14%)
Query: 207 ESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAK 266
E D + E+ K K+K ++ +K+ ++ K+ K + D K+ K+E E+K
Sbjct: 125 EGDRVEEDGKGKRKNEKAGSKRKKSYTSKKSSKQSRKSPGDEDDKDCKEE-ENK------ 177
Query: 267 TGVTSTSDSEEEGDD 281
S+S+ + G+D
Sbjct: 178 ----SSSEGGDAGND 188
>gi|4758516 hepatoma-derived growth factor isoform a [Homo sapiens]
Length = 240
Score = 185 bits (469), Expect = 1e-46
Identities = 112/265 (42%), Positives = 154/265 (58%), Gaps = 41/265 (15%)
Query: 3 RDFKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFPYS 62
+++K GDL+FAKMKGYPHWPAR+DE+P+ AVK NK +FFFGTHETAFLGPKD+FPY
Sbjct: 8 KEYKCGDLVFAKMKGYPHWPARIDEMPEAAVKSTANKYQVFFFGTHETAFLGPKDLFPYE 67
Query: 63 ENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDT 122
E+KEK+GKPNKRKGF+EGLWEI+NNP VK S Q++ K+ S VE E E ++ D
Sbjct: 68 ESKEKFGKPNKRKGFSEGLWEIENNPTVKASGYQSSQKK----SCVEEPEPEPEAAEGDG 123
Query: 123 D---HEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPK 179
D + E +S+E+ +D K K EK AG + L+ SPK
Sbjct: 124 DKKGNAEGSSDEEGKLVID--------EPAKEKNEKGALKRRAGDL--------LEDSPK 167
Query: 180 RGRPAATEVKIPKPRGRPK-----MVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKD 234
R + A P G K V++P P E E++ + + + P P+++
Sbjct: 168 RPKEA------ENPEGEEKEAATLEVERPLPME----VEKNSTPSEPGSGRGP---PQEE 214
Query: 235 EEGQKEEDKPRKEPDKKEGKKEVES 259
EE + EE++ KE + G ++ ES
Sbjct: 215 EEEEDEEEEATKEDAEAPGIRDHES 239
Score = 32.0 bits (71), Expect = 1.4
Identities = 26/116 (22%), Positives = 51/116 (43%), Gaps = 10/116 (8%)
Query: 235 EEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTST------SDSEEEGDDQEGEKKR 288
EE +++ KP K EG E+E+ + +G S+ + E E + EG+ +
Sbjct: 67 EESKEKFGKPNKRKGFSEGLWEIEN-NPTVKASGYQSSQKKSCVEEPEPEPEAAEGDGDK 125
Query: 289 KGGRNFQTAHRRNMLKGQHEKEAADR---KRKQEEQMETEQQNKDEGKKPEVKKVE 341
KG + ++ + KE ++ KR+ + +E + E + PE ++ E
Sbjct: 126 KGNAEGSSDEEGKLVIDEPAKEKNEKGALKRRAGDLLEDSPKRPKEAENPEGEEKE 181
>gi|186928819 hepatoma-derived growth factor isoform b [Homo
sapiens]
Length = 256
Score = 145 bits (365), Expect = 1e-34
Identities = 96/246 (39%), Positives = 134/246 (54%), Gaps = 41/246 (16%)
Query: 22 PARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFPYSENKEKYGKPNKRKGFNEGL 81
P +DE+P+ AVK NK +FFFGTHETAFLGPKD+FPY E+KEK+GKPNKRKGF+EGL
Sbjct: 43 PHTIDEMPEAAVKSTANKYQVFFFGTHETAFLGPKDLFPYEESKEKFGKPNKRKGFSEGL 102
Query: 82 WEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTD---HEEKASNEDVTKAVD 138
WEI+NNP VK S Q++ K+ S VE E E ++ D D + E +S+E+ +D
Sbjct: 103 WEIENNPTVKASGYQSSQKK----SCVEEPEPEPEAAEGDGDKKGNAEGSSDEEGKLVID 158
Query: 139 ITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPK 198
K K EK AG + L+ SPKR + A P G K
Sbjct: 159 --------EPAKEKNEKGALKRRAGDL--------LEDSPKRPKEA------ENPEGEEK 196
Query: 199 -----MVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEG 253
V++P P E E++ + + + P P+++EE + EE++ KE + G
Sbjct: 197 EAATLEVERPLPME----VEKNSTPSEPGSGRGP---PQEEEEEEDEEEEATKEDAEAPG 249
Query: 254 KKEVES 259
++ ES
Sbjct: 250 IRDHES 255
Score = 32.0 bits (71), Expect = 1.4
Identities = 26/116 (22%), Positives = 51/116 (43%), Gaps = 10/116 (8%)
Query: 235 EEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTST------SDSEEEGDDQEGEKKR 288
EE +++ KP K EG E+E+ + +G S+ + E E + EG+ +
Sbjct: 83 EESKEKFGKPNKRKGFSEGLWEIEN-NPTVKASGYQSSQKKSCVEEPEPEPEAAEGDGDK 141
Query: 289 KGGRNFQTAHRRNMLKGQHEKEAADR---KRKQEEQMETEQQNKDEGKKPEVKKVE 341
KG + ++ + KE ++ KR+ + +E + E + PE ++ E
Sbjct: 142 KGNAEGSSDEEGKLVIDEPAKEKNEKGALKRRAGDLLEDSPKRPKEAENPEGEEKE 197
>gi|186928821 hepatoma-derived growth factor isoform c [Homo
sapiens]
Length = 233
Score = 144 bits (362), Expect = 3e-34
Identities = 96/245 (39%), Positives = 134/245 (54%), Gaps = 41/245 (16%)
Query: 23 ARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFPYSENKEKYGKPNKRKGFNEGLW 82
A +DE+P+ AVK NK +FFFGTHETAFLGPKD+FPY E+KEK+GKPNKRKGF+EGLW
Sbjct: 21 AVIDEMPEAAVKSTANKYQVFFFGTHETAFLGPKDLFPYEESKEKFGKPNKRKGFSEGLW 80
Query: 83 EIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTD---HEEKASNEDVTKAVDI 139
EI+NNP VK S Q++ K+ S VE E E ++ D D + E +S+E+ +D
Sbjct: 81 EIENNPTVKASGYQSSQKK----SCVEEPEPEPEAAEGDGDKKGNAEGSSDEEGKLVID- 135
Query: 140 TTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPK- 198
K K EK AG + L+ SPKR + A P G K
Sbjct: 136 -------EPAKEKNEKGALKRRAGDL--------LEDSPKRPKEA------ENPEGEEKE 174
Query: 199 ----MVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGK 254
V++P P E E++ + + + P P+++EE + EE++ KE + G
Sbjct: 175 AATLEVERPLPME----VEKNSTPSEPGSGRGP---PQEEEEEEDEEEEATKEDAEAPGI 227
Query: 255 KEVES 259
++ ES
Sbjct: 228 RDHES 232
Score = 32.0 bits (71), Expect = 1.4
Identities = 26/116 (22%), Positives = 51/116 (43%), Gaps = 10/116 (8%)
Query: 235 EEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTST------SDSEEEGDDQEGEKKR 288
EE +++ KP K EG E+E+ + +G S+ + E E + EG+ +
Sbjct: 60 EESKEKFGKPNKRKGFSEGLWEIEN-NPTVKASGYQSSQKKSCVEEPEPEPEAAEGDGDK 118
Query: 289 KGGRNFQTAHRRNMLKGQHEKEAADR---KRKQEEQMETEQQNKDEGKKPEVKKVE 341
KG + ++ + KE ++ KR+ + +E + E + PE ++ E
Sbjct: 119 KGNAEGSSDEEGKLVIDEPAKEKNEKGALKRRAGDLLEDSPKRPKEAENPEGEEKE 174
>gi|110681712 hepatoma derived growth factor-like 1 [Homo sapiens]
Length = 251
Score = 135 bits (340), Expect = 9e-32
Identities = 81/238 (34%), Positives = 118/238 (49%), Gaps = 27/238 (11%)
Query: 5 FKPGDLIFAKMKGYPHWPARVDEVPDGAVKPPTNKLPIFFFGTHETAFLGPKDIFPYSEN 64
+K GDL+FAK+KGY HWPAR++ + N+ +FFFGTHETAFL PK +FPY E
Sbjct: 9 YKSGDLVFAKLKGYAHWPARIEHMTQ------PNRYQVFFFGTHETAFLSPKRLFPYKEC 62
Query: 65 KEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDH 124
KEK+GKPNKR+GF+ GLWEI+NNP V+ S A+++ S D E E + ED
Sbjct: 63 KEKFGKPNKRRGFSAGLWEIENNPTVQASDCPLASEK--GSGDGPWPEPEAAEGDEDKPT 120
Query: 125 EEKASNEDVTKAVDITTPKAARRGRKRKA------------------EKQVETEEAGVVT 166
+++ K D + + KR A E++ E E A
Sbjct: 121 HAGGGGDELGKPDDDKPTEEEKGPLKRSAGDPPEDAPKRPKEAAPDQEEEAEAERAAEAE 180
Query: 167 TATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEE 224
A A+ + P V+ P +V +P E + + EE+ + ++ +E
Sbjct: 181 RAAAAAAATAVDEES-PFLVAVENGSAPSEPGLVCEPPQPEEEELREEEVADEEASQE 237
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 75.9 bits (185), Expect = 9e-14
Identities = 81/300 (27%), Positives = 126/300 (42%), Gaps = 36/300 (12%)
Query: 83 EIDNNPKVKFSSQQAATKQSNASSDVEVE----EKETSVSKEDTDHEEKASNEDVTKAVD 138
E + K K ++ A A S V+ E EK S KE+ EKA + + K +D
Sbjct: 701 EAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLD 760
Query: 139 ITTPKA-------ARRGRKRKAEKQVETEEAGVVTTATASVNLKV---SPKRGRPAATEV 188
+ +P+A AR + EK + V + A LK +P++ P EV
Sbjct: 761 VKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEV 820
Query: 189 KIP-KPRGRPKMVKQPCP-----SESDIITEEDKSKKKGQEEKQP-KKQPKKDEEGQKEE 241
K P K +P+ VK P E T + + KK ++E+ P K+ PK E +KE
Sbjct: 821 KSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEP 880
Query: 242 DKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRN 301
+ + K E KKE +K + + + E + D + EK + A +
Sbjct: 881 AVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKE 940
Query: 302 MLKGQHEKEAADRK--------RKQEEQMETEQQNKDEGK-------KPEVKKVEKKRET 346
K +KEAA K +K EE+ +TE + K++ K KP+ +K EK T
Sbjct: 941 PSKPAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSST 1000
Score = 70.9 bits (172), Expect = 3e-12
Identities = 99/472 (20%), Positives = 178/472 (37%), Gaps = 37/472 (7%)
Query: 83 EIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASN---EDVTKAVDI 139
E+ + K K +++ A A S EKE + S + EKA + E+ +
Sbjct: 543 EVKSPEKAKSPAKEEAKSPPEAKSP----EKEEAKSPAEVKSPEKAKSPAKEEAKSPAEA 598
Query: 140 TTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKM 199
+P+ A+ K +A+ E + V A + +K K P E K P+ P+
Sbjct: 599 KSPEKAKSPVKEEAKSPAEAKSP-VKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEK 657
Query: 200 --VKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKP---RKEPDKKEGK 254
K P ++S + E +K K K P+K + KEE K K P K+E K
Sbjct: 658 EEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAK 717
Query: 255 KEVESKR--KNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHE-KEA 311
++K K AKT + S +EE E K + + + E +
Sbjct: 718 SPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSP 777
Query: 312 ADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVN 371
AD+ ++ + E+ E K +K+ K E + + + + + +K K + V
Sbjct: 778 ADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKK-EEVKSPVKEEEKPQEVKVK 836
Query: 372 RCIEALDELASLQVTMQQAQKHTEMITTLKK--------------IRRFKVSQVIMEKST 417
+ +E + + +K ++ KK + + K S+V +K
Sbjct: 837 EPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEE 896
Query: 418 MLYNKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGK-KGPNKKLEKEQTG-- 474
+ K E ++ + + + + E A K D K K P+K EK++
Sbjct: 897 A---EDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAPE 953
Query: 475 SKTLNGGSDAQDGNQPQHNGESNEDSKDNHEASTKKKPSSEERETEISLKDS 526
K + +P+ ++ ED K + +K K E+ + KDS
Sbjct: 954 KKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDS 1005
Score = 68.2 bits (165), Expect = 2e-11
Identities = 105/486 (21%), Positives = 183/486 (37%), Gaps = 46/486 (9%)
Query: 63 ENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDT 122
E KE+ GK + +G E E +++AA+ + A S V+ E K + +K
Sbjct: 477 EAKEEEGK--EEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPE 534
Query: 123 DHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGR 182
E K+ E + +P+ A+ K +A+ E + A + +K K
Sbjct: 535 KEEAKSPAE-------VKSPEKAKSPAKEEAKSPPEAKSPEK-EEAKSPAEVKSPEKAKS 586
Query: 183 PAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEED 242
PA E K P P+ K P E+ E K+ + K P+K + KEE
Sbjct: 587 PAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEA 646
Query: 243 KP---RKEPDKKEGKK--------EVESKRKNLAKTGVTSTSDSEEEGDD---QEGEKKR 288
K K P+K+E K + E+K AK+ V + + S E+ +E +
Sbjct: 647 KSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPE 706
Query: 289 KGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPE------VKKVEK 342
K + + KE A K + ++ E ++ ++ K PE VK E
Sbjct: 707 KAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEA 766
Query: 343 KRETSMDSR--LQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTL 400
K ++R + + K+ +K + + L E A + ++ K E+ + +
Sbjct: 767 KTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDA--KAPEKEIPKKEEVKSPV 824
Query: 401 KKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQG 460
K+ K +V +++ + K + T+ S E+ +EA K K +
Sbjct: 825 KE--EEKPQEVKVKEPPKKAEEEK------APATPKTEEKKDSKKEEAPKKEAPKPKVEE 876
Query: 461 KKGPNKKLEKEQTGSKTLNGGSDAQDGNQPQHNG----ESNEDSKDNHEASTKKKPSSEE 516
KK P + KE D + P+ E ED+K + KK +
Sbjct: 877 KKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDA 936
Query: 517 RETEIS 522
+ E S
Sbjct: 937 KAKEPS 942
Score = 65.1 bits (157), Expect = 2e-10
Identities = 109/463 (23%), Positives = 174/463 (37%), Gaps = 43/463 (9%)
Query: 88 PKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARR 147
PK+ S K VE EKET + +E T EE E+VT+ + K A+
Sbjct: 427 PKIPSVSTHIKVKSEEKIKVVEKSEKETVIVEEQT--EETQVTEEVTEEEE----KEAKE 480
Query: 148 GRKRKAEKQVETE-EAGVVTTATASVNLKVSPKRGR--PAATEVKIPKPRGRPKMVKQPC 204
++ E E E E G T + SP++ P E K P P+ +
Sbjct: 481 EEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKS 540
Query: 205 PSESDIITEEDKSKKKGQEE-KQP--KKQPKKDEEGQKEEDK---PRKEPDKKEGKKEVE 258
P+E + +K+K +EE K P K P+K+E E K K P K+E K E
Sbjct: 541 PAE---VKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAE 597
Query: 259 SKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQ---------HEK 309
+K AK+ V + S E E+ + ++ K + EK
Sbjct: 598 AKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEK 657
Query: 310 EAADRKRKQEEQMETEQQNKDEGKKP---EVKKVEKKRETSMDSRL--QRIHAEIKNSLK 364
E A K + ++ E ++ ++ K P E K EK + + ++ + +K K
Sbjct: 658 EEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAK 717
Query: 365 IDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQ-----VIMEKSTML 419
+ E + +++ K E + +K + V E++
Sbjct: 718 SPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSP 777
Query: 420 YNKFKNMFLVGEGDSVITQVLNKS-LAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTL 478
+KF + V + KS L E + E K + K P K+ EK Q K
Sbjct: 778 ADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQE-VKVK 836
Query: 479 NGGSDAQDGNQP-QHNGESNEDSKDNHEASTKK--KPSSEERE 518
A++ P E +DSK EA K+ KP EE++
Sbjct: 837 EPPKKAEEEKAPATPKTEEKKDSK-KEEAPKKEAPKPKVEEKK 878
Score = 63.2 bits (152), Expect = 6e-10
Identities = 92/444 (20%), Positives = 179/444 (40%), Gaps = 38/444 (8%)
Query: 62 SENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKED 121
S KE+ P + K + + K ++ +++ + ++V+ EK S +KE+
Sbjct: 586 SPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEE 645
Query: 122 TDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKV---SP 178
EKA + + +A K+ + + EK +A + A +K SP
Sbjct: 646 AKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSP 705
Query: 179 KRGR-PAATEVKIPKPRGRPKMVKQPCPSESDI-ITEEDKSKKKGQEEKQPK----KQPK 232
++ + P E K P+ P + P ++ + EE KS +K + ++ K K P+
Sbjct: 706 EKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPE 765
Query: 233 KDEEGQKEEDKPR-KEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKK---R 288
++E P K P+K + + E K AK+ + + + E+ ++ E K +
Sbjct: 766 AKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVK 825
Query: 289 KGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVK---------- 338
+ + + + K + EK A K ++++ + E+ K E KP+V+
Sbjct: 826 EEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKP 885
Query: 339 ---KVEKKRETSMDSR---LQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQK 392
KVE K+E + D + A K +K D + E+A + +A++
Sbjct: 886 KESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEK-----TEVAKKEPDDAKAKE 940
Query: 393 HTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAEQRQHEE 452
++ KK + EK+ K K E D +++ +K AE+ E+
Sbjct: 941 PSK--PAEKKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKA--EK 996
Query: 453 ANKTKDQGKKGPNKKLEKEQTGSK 476
++ T + K P K E + K
Sbjct: 997 SSSTDQKDSKPPEKATEDKAAKGK 1020
Score = 41.2 bits (95), Expect = 0.002
Identities = 41/207 (19%), Positives = 91/207 (43%), Gaps = 13/207 (6%)
Query: 163 GVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQ 222
G+ + S ++KV + ++K+ + + ++ + E+ + E + ++K
Sbjct: 425 GLPKIPSVSTHIKVKSEE------KIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEA 478
Query: 223 EEKQPKKQ---PKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEG 279
+E++ K++ +++ EG +EE K + +KE +S K AK+ + S +EE
Sbjct: 479 KEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEA 538
Query: 280 DDQEGEKKRKGGRNFQTAHRRNMLKGQH-EKEAADRKRKQEEQMETEQQNKDEGKKP-EV 337
K + ++ ++ + + EKE A + + + + K+E K P E
Sbjct: 539 KSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEA 598
Query: 338 KKVEKKRETSMDSRLQRIHAEIKNSLK 364
K EK + + + AE K+ +K
Sbjct: 599 KSPEKAKSPVKEE--AKSPAEAKSPVK 623
>gi|13540523 nucleosomal binding protein 1 [Homo sapiens]
Length = 282
Score = 72.4 bits (176), Expect = 1e-12
Identities = 62/243 (25%), Positives = 108/243 (44%), Gaps = 19/243 (7%)
Query: 113 KETSVSKEDTDHEEKASNEDVTKAVDITTP--KAARRGRKRKAEKQVETEEAGVVTTATA 170
K + + D E K + ++ + TP K R RK + + + E + T+A A
Sbjct: 3 KRKAAGQGDMRQEPKRRSARLSAMLVPVTPEVKPKRTSSSRKMKTKSDMMEENIDTSAQA 62
Query: 171 SVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITE-----EDKSKKKGQEEK 225
K K G K+ + P SE +I+ ED ++K G++++
Sbjct: 63 VAETKQEAVVEEDYNENAK----NGEAKITEAPA-SEKEIVEVKEENIEDATEKGGEKKE 117
Query: 226 QPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGE 285
+ K +EE QKE+++ + E + GK++ + K + K E+ + ++G+
Sbjct: 118 AVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGK 177
Query: 286 KKRKGGRNFQTAHRRNMLKGQHEKEAADRKRK---QEEQMETEQQNKDEGKKPEVKKVEK 342
K G N + KG+ EKE DRK +E + E+ +K EGK +VK+ EK
Sbjct: 178 KGEDGKGNGEDGKE----KGEDEKEEEDRKETGDGKENEDGKEKGDKKEGKDVKVKEDEK 233
Query: 343 KRE 345
+RE
Sbjct: 234 ERE 236
Score = 59.3 bits (142), Expect = 8e-09
Identities = 66/273 (24%), Positives = 119/273 (43%), Gaps = 47/273 (17%)
Query: 88 PKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARR 147
PK SS++ TK +++ + + +K++ EE + IT A+ +
Sbjct: 36 PKRTSSSRKMKTKSDMMEENIDTSAQAVAETKQEAVVEEDYNENAKNGEAKITEAPASEK 95
Query: 148 GRKRKAEKQVE--TEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCP 205
E+ +E TE+ G ++ A EVK K ++
Sbjct: 96 EIVEVKEENIEDATEKGG---------------EKKEAVAAEVK--NEEEDQKEDEEDQN 138
Query: 206 SESDIITEEDKSKKKGQEE-KQPKKQPKKDEEGQKEEDKPRKEPDKKEG-----KKEVES 259
E +EDK +K G+E+ K+ K +K E+ +++ED + E K G K E E
Sbjct: 139 EEKGEAGKEDKDEK-GEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKGNGEDGKEKGEDEK 197
Query: 260 KRKNLAKTG-VTSTSDSEEEGDDQEG--------EKKRKGGRNFQTAHRRNMLKGQHEKE 310
+ ++ +TG D +E+GD +EG EK+R+ G+ + G +E+E
Sbjct: 198 EEEDRKETGDGKENEDGKEKGDKKEGKDVKVKEDEKEREDGKEDE---------GGNEEE 248
Query: 311 AADRK---RKQEEQMETEQQNKDEGKKPEVKKV 340
A K +++EE E ++ +D+GKK E + +
Sbjct: 249 AGKEKEDLKEEEEGKEEDEIKEDDGKKEEPQSI 281
Score = 39.3 bits (90), Expect = 0.009
Identities = 49/205 (23%), Positives = 90/205 (43%), Gaps = 22/205 (10%)
Query: 168 ATASVNLKVSPKRGRPAATEVKIP-KPRGRPKMVK--QPCPSESDIITEE-DKSKKKGQE 223
A +++ PKR + + +P P +PK + ++SD++ E D S + E
Sbjct: 6 AAGQGDMRQEPKRRSARLSAMLVPVTPEVKPKRTSSSRKMKTKSDMMEENIDTSAQAVAE 65
Query: 224 EKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLA---------KTGVTSTSD 274
KQ + E K + E E K+ VE K +N+ K V +
Sbjct: 66 TKQEAVVEEDYNENAKNGEAKITEAPASE-KEIVEVKEENIEDATEKGGEKKEAVAAEVK 124
Query: 275 SEEEG--DDQEGEKKRKGGRNFQTAHRRNMLKGQHEK----EAADRKRKQE-EQMETEQQ 327
+EEE +D+E + + KG + + G+ +K + D K K++ ++ E +
Sbjct: 125 NEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKG 184
Query: 328 NKDEGK-KPEVKKVEKKRETSMDSR 351
N ++GK K E +K E+ R+ + D +
Sbjct: 185 NGEDGKEKGEDEKEEEDRKETGDGK 209
Score = 36.6 bits (83), Expect = 0.058
Identities = 24/98 (24%), Positives = 51/98 (52%), Gaps = 12/98 (12%)
Query: 433 DSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEK-EQTGSKTLNG---GSDAQD-- 486
++V +V N+ E ++ +E ++ +++G+ G K EK E+ G + NG G DA++
Sbjct: 117 EAVAAEVKNEE--EDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKE 174
Query: 487 ----GNQPQHNGESNEDSKDNHEASTKKKPSSEERETE 520
G + NGE ++ ++ + +K + + +E E
Sbjct: 175 DGKKGEDGKGNGEDGKEKGEDEKEEEDRKETGDGKENE 212
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 72.4 bits (176), Expect = 1e-12
Identities = 58/247 (23%), Positives = 109/247 (44%), Gaps = 11/247 (4%)
Query: 111 EEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATA 170
+E+E +E EK N K + T + RGR R+ + Q E E A
Sbjct: 103 KERERQTDRERDRQREKERNRQ--KERERETEREGERGRDRQTDGQRERERQ-----RDA 155
Query: 171 SVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITE---EDKSKKKGQEEKQP 227
+ R R TE K R R K ++ E E ED+ ++G+E ++
Sbjct: 156 EKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERER- 214
Query: 228 KKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKK 287
+++ + + E +++ D+ R K E ++E +++R+ ++ + E E D +
Sbjct: 215 ERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDR 274
Query: 288 RKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETS 347
R+ R QT +R + + R+R++E + E E+ K E ++ ++ E++RET
Sbjct: 275 RQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETE 334
Query: 348 MDSRLQR 354
D +R
Sbjct: 335 RDREKER 341
Score = 67.4 bits (163), Expect = 3e-11
Identities = 58/287 (20%), Positives = 122/287 (42%), Gaps = 39/287 (13%)
Query: 94 SQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKA 153
+++ +Q++ + E + + + +E+ E + + T + + RGR+R+
Sbjct: 155 AEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERER 214
Query: 154 EKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITE 213
E++ ETE + +R R TE + K R + ++ +E D E
Sbjct: 215 ERETETE---------TERKRQTDRERDRQRKTEREREKQAERERASERE--TERDKERE 263
Query: 214 EDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTS 273
++ + + ++ +Q +++ + D + Q+ ++ R+ K+E ++E E +R+ K
Sbjct: 264 RERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERER 323
Query: 274 DSEEEGD-----DQEGEKKRKGGRNFQTAHRRNMLKGQH--------------------- 307
+ E E D+E E++RK R + RN G+
Sbjct: 324 ERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAR 383
Query: 308 EKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQR 354
E+E +R R ++ Q E E+Q E + ++ EK+RE D +R
Sbjct: 384 EREERERDRDRDRQKERERQT--EKDRDGQRETEKQREREKDRESER 428
Score = 58.5 bits (140), Expect = 1e-08
Identities = 55/314 (17%), Positives = 141/314 (44%), Gaps = 10/314 (3%)
Query: 213 EEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTST 272
E+D+ +K+ + ++ + + +K+ E Q + ++ R+ ++ +KE E + + + G
Sbjct: 84 EKDRHRKRDRHRERQRDR-EKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQ 142
Query: 273 SDSEEEGD---DQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNK 329
+D + E + D E E++R+ R Q RN K + E+E +R+ ++E + + E++NK
Sbjct: 143 TDGQRERERQRDAEKERERQTDRERQRQTERNRQK-ERERE-KNRQERRERERQREKENK 200
Query: 330 DEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQ 389
E + E + E++RE ++ +R + + + R +A E AS + T +
Sbjct: 201 TEDRHSE-RGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERD 259
Query: 390 AQKHTEMITTLKKIRRFKVSQVIMEKSTML---YNKFKNMFLVGEGDSVITQVLNKSLAE 446
++ E + RR K + ++ ++ + + + N+
Sbjct: 260 KERERERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRER 319
Query: 447 QRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQPQHNGESNEDSKDNHEA 506
+R+ E + + + ++ K+ E+++ ++ + Q G + + E + + +
Sbjct: 320 ERERERERERQRETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDR 379
Query: 507 STKKKPSSEERETE 520
+ ++ ER+ +
Sbjct: 380 QSAREREERERDRD 393
Score = 53.5 bits (127), Expect = 5e-07
Identities = 56/272 (20%), Positives = 116/272 (42%), Gaps = 44/272 (16%)
Query: 83 EIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTP 142
E D K + ++ A ++ + + E +++ D D + + +
Sbjct: 231 ERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERE---------- 280
Query: 143 KAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQ 202
+ R R+R+ E+ ETE KR R E + + R R + ++
Sbjct: 281 RQTDRKRQRRTERDRETER-----------------KRERQRERERERERNRKRERERER 323
Query: 203 PCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRK 262
E TE D+ K E++ K+ + Q E D+ R +EG+++ E +R+
Sbjct: 324 ERERERQRETERDREK-----ERERKR------KRQTEMDRERNRQTGREGRRQAERERE 372
Query: 263 NLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQM 322
+ S + EE D++ +++++ R QT R+ GQ E E R+R+++ +
Sbjct: 373 RERERDRQSAREREERERDRDRDRQKE--RERQTEKDRD---GQRETE-KQREREKDRES 426
Query: 323 ETEQQNKDEGKKPEVKKVEKKRETSMDSRLQR 354
E ++ E +K + ++ +++R+T + QR
Sbjct: 427 ERGRERGREREKQKGRERDRERQTDRQAGRQR 458
Score = 53.1 bits (126), Expect = 6e-07
Identities = 68/370 (18%), Positives = 149/370 (40%), Gaps = 42/370 (11%)
Query: 155 KQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEE 214
K++ A + T V + + R RP + E P+ RG + K + +
Sbjct: 3 KKIVPATADQLGTLWVEVTIPLDFSRRRPGSQES--PRRRGLGQAHKDADGDDRE--RNR 58
Query: 215 DKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSD 274
K +++ +E++Q +++ + E ++E+D+ RK +E +++ E +R+ +
Sbjct: 59 QKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQRE 118
Query: 275 SEEEGD-DQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGK 333
E ++E E +R+G R R GQ E+E R+R E++ E + + + +
Sbjct: 119 KERNRQKERERETEREGERG-----RDRQTDGQRERE---RQRDAEKERERQTDRERQRQ 170
Query: 334 KPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKH 393
++ E++RE + R +R K + K ++ R E E + T ++ Q
Sbjct: 171 TERNRQKEREREKNRQERRERERQREKEN-KTEDRHSERGRERERERETETETERKRQTD 229
Query: 394 TEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEA 453
E +K R + Q E++ ++ E+ + E
Sbjct: 230 RER-DRQRKTEREREKQAERERA------------------------SERETERDKERER 264
Query: 454 NKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQPQHNGESNEDSKDNHEASTKKKPS 513
+ +D+ + K+ E++ + D + + + E + + N + +++
Sbjct: 265 ERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERE 324
Query: 514 SE---ERETE 520
E +RETE
Sbjct: 325 RERERQRETE 334
>gi|87299628 biorientation of chromosomes in cell division 1-like
[Homo sapiens]
Length = 3051
Score = 72.0 bits (175), Expect = 1e-12
Identities = 94/451 (20%), Positives = 186/451 (41%), Gaps = 53/451 (11%)
Query: 102 SNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEE 161
S++ ++ VE++ S++KE EE+ + + + RK+KAEK ++
Sbjct: 482 SDSDDELTVEQRRQSIAKEK---EERLLRRQINR-------EKLEEKRKQKAEKTKSSKT 531
Query: 162 AGVVTTATASVNLKVSPKRG-RPAATEVK--IPKPRGRPKMVKQPCPSESDIITEEDKSK 218
G +SV+L+ S + P A +K + + + K V + D E+ SK
Sbjct: 532 KG---QGRSSVDLEESSTKSLEPKAARIKEVLKERKVLEKKVALSKKRKKDSRNVEENSK 588
Query: 219 KKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEE 278
KK Q E+ K+ K E +KE+ KE K E + L+++ D +
Sbjct: 589 KKQQYEEDSKETLKTSEHCEKEKISSSKELKHVHAKSEPSKPARRLSES--LHVVDENKN 646
Query: 279 GDDQEGEKKRK-------GGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQ-NKD 330
E E KR+ G +T R + + + + +KQ+ ++ E+ KD
Sbjct: 647 ESKLEREHKRRTSTPVIMEGVQEETDTRDVKRQVERSEICTEEPQKQKSTLKNEKHLKKD 706
Query: 331 EGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQA 390
+ + P +K + KK S + +R ++ L + + C+ + L + ++
Sbjct: 707 DSETPHLKSLLKKEVKSSKEKPEREKTPSEDKLSVKHKYKGDCMHKTGDETELH-SSEKG 765
Query: 391 QKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNK-------- 442
K E I K+ ++ K+S + + + + ++G+ +++ + K
Sbjct: 766 LKVEENIQ--KQSQQTKLSSDDKTERKSKHRNERKLSVLGKDGKPVSEYIIKTDENVRKE 823
Query: 443 -SLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQPQHNGESNEDSK 501
+ E+R E K + + ++ + K++K+ GSK Q G Q ES + K
Sbjct: 824 NNKKERRLSAEKTKAEHKSRRSSDSKIQKDSLGSK--------QHGITLQRRSESYSEDK 875
Query: 502 ---DNHEASTKKKPS----SEERETEISLKD 525
D+ + KP E+R T+ L++
Sbjct: 876 CDMDSTNMDSNLKPEEVVHKEKRRTKSLLEE 906
Score = 52.4 bits (124), Expect = 1e-06
Identities = 95/450 (21%), Positives = 179/450 (39%), Gaps = 74/450 (16%)
Query: 93 SSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRK 152
S+ +A+T+ SNA + +K S DT +++ ++ED+
Sbjct: 216 SAARASTETSNAKTSERASKKLPSQPTTDTSTDKERTSEDM------------------- 256
Query: 153 AEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKM----------VKQ 202
A+K+ T ++G L+ +PK + + + + K V+Q
Sbjct: 257 ADKEKSTADSG-------GEGLETAPKSEEFSDLPCPVEEIKNYTKEHNNLILLNKDVQQ 309
Query: 203 PCPSESDIITEEDKSK----KKGQEEKQPK-KQPKKDEEGQKEEDKPRKEPDKKEGKKEV 257
+ + T++ + K +KG+ +K+ K K KK + +K ED + + +K+ +KEV
Sbjct: 310 ESSEQKNKSTDKGEKKPDSNEKGERKKEKKEKTEKKFDHSKKSEDTQKVKDEKQAKEKEV 369
Query: 258 ES------KRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNM--LKGQHEK 309
ES K N AKT + D D +G + H ++ + E+
Sbjct: 370 ESLKLPSEKNSNKAKTVEGTKEDFSLIDSDVDG----LTDITVSSVHTSDLSSFEEDTEE 425
Query: 310 EAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLD 369
E +E ++ ++ + K++ K + + + + R +H S + D
Sbjct: 426 EVVTSDSMEEGEITSDDEEKNKQNKTKTQTSDSSEGKTKSVRHAYVHKPYLYSKYYSDSD 485
Query: 370 VNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLV 429
DEL +++ Q K E ++I R K+ EK K K+
Sbjct: 486 --------DEL-TVEQRRQSIAKEKEERLLRRQINREKLE----EKRKQKAEKTKSSKTK 532
Query: 430 GEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGN- 488
G+G S + L +S + + +A + K+ K+ K LEK+ SK S + N
Sbjct: 533 GQGRSSVD--LEESSTKSLE-PKAARIKEVLKE--RKVLEKKVALSKKRKKDSRNVEENS 587
Query: 489 --QPQHNGESNEDSKDNHEASTKKKPSSEE 516
+ Q+ +S E K + +K SS+E
Sbjct: 588 KKKQQYEEDSKETLKTSEHCEKEKISSSKE 617
Score = 42.7 bits (99), Expect = 8e-04
Identities = 45/195 (23%), Positives = 86/195 (44%), Gaps = 28/195 (14%)
Query: 99 TKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVE 158
+ ++N+++ +EEK+ S E T + + +++D K+ + P +R R R + VE
Sbjct: 2825 SSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQPIIIKRKRGRPRKYPVE 2884
Query: 159 TE---------EAGVVTT--ATASVNLKV--SPKRGRPAAT--EVKIPKPRGRPKMV--- 200
T + G+VT + +S LKV + + + A E I G K+V
Sbjct: 2885 TTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQERSISNDDGEEKIVTSV 2944
Query: 201 ----KQPCPS--ESDIITEEDKSKKKGQEEKQP----KKQPKKDEEGQKEEDKPRKEPDK 250
++P S SD + +K+ + P K+Q +EE ++EED+P +
Sbjct: 2945 RRRGRKPKRSLTVSDDAESSEPERKRQKSVSDPVEDKKEQESDEEEEEEEEDEPSGATTR 3004
Query: 251 KEGKKEVESKRKNLA 265
+ E + + L+
Sbjct: 3005 STTRSEAQRSKTQLS 3019
Score = 40.0 bits (92), Expect = 0.005
Identities = 56/298 (18%), Positives = 117/298 (39%), Gaps = 31/298 (10%)
Query: 55 PKDIFPYSENKEKYGKPNKRKG-FNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEK 113
PK++ E +E++ KRK + E D+NP V S + A +Q + + +E+
Sbjct: 2758 PKEV----EEEERHMPKRKRKQHYLSSEDEPDDNPDVLDSRIETAQRQCPETEPHDTKEE 2813
Query: 114 ETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVN 173
+ D + K S+E + + K + EK + ++ + +
Sbjct: 2814 NS----RDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDD-DTIKSQEEDQP 2868
Query: 174 LKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIIT-EEDKSKKKGQEEKQPKKQPK 232
+ + KRGRP V+ +K +++ I+T E+ S K K +
Sbjct: 2869 IIIKRKRGRPRKYPVETTLK------MKDDSKTDTGIVTVEQSPSSSK-------LKVMQ 2915
Query: 233 KDEEGQKEEDKPRKEPDKKEGKKEVES---KRKNLAKTGVTSTSDSEEEGDDQEGEKKRK 289
DE ++ + + +G++++ + +R K +T + D+E E E+KR+
Sbjct: 2916 TDESNKETANLQERSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESS----EPERKRQ 2971
Query: 290 GGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETS 347
+ ++ + E+E + + T + K +++KRE S
Sbjct: 2972 KSVSDPVEDKKEQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKTQLSPSIKRKREVS 3029
Score = 39.3 bits (90), Expect = 0.009
Identities = 50/245 (20%), Positives = 88/245 (35%), Gaps = 21/245 (8%)
Query: 127 KASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAAT 186
+ S + A P + R+ + K +++E G T ++ KR P A
Sbjct: 1311 EGSTASTSPADHSALPNQSLTVRESEVLKTSDSKEGGEGFTVDTPAKASITSKRHIPEAH 1370
Query: 187 EVKIPKPRGRPKMVKQPCPSESD--IITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKP 244
+ + G+ V P S+ I+ E+ +K+ G + K+ E K+ K
Sbjct: 1371 QATLLD--GKQGKVIMPLGSKLTGVIVENENITKEGGLVDMAKKENDLNAEPNLKQTIKA 1428
Query: 245 RKEPDKKEG--------------KKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKG 290
E KK+G + V+ K K + D E ++ E +
Sbjct: 1429 TVENGKKDGIAVDHVVGLNTEKYAETVKLKHKRSPGKVKDISIDVERRNENSEVDTSAGS 1488
Query: 291 GRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDS 350
G H+RN GQ E A +R ++ + T + KD+ K TS ++
Sbjct: 1489 GSAPSVLHQRN---GQTEDVATGPRRAEKTSVATSTEGKDKDVTLSPVKAGPATTTSSET 1545
Query: 351 RLQRI 355
R +
Sbjct: 1546 RQSEV 1550
Score = 35.0 bits (79), Expect = 0.17
Identities = 57/274 (20%), Positives = 96/274 (35%), Gaps = 21/274 (7%)
Query: 213 EEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTST 272
E D + + +E PK+ K+ + ED+P PD + + +E+ ++ +T T
Sbjct: 2755 EADPKEVEEEERHMPKR--KRKQHYLSSEDEPDDNPDVLDSR--IETAQRQCPETEPHDT 2810
Query: 273 SDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDE- 331
EE D E K N T+ E K +Q + + Q +D+
Sbjct: 2811 --KEENSRDLEELPKTSSETNSTTSRVMEEKDEYSSSETTGEKPEQNDDDTIKSQEEDQP 2868
Query: 332 ------GKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQV 385
+P VE + DS+ ++ S L V + E+ E A+LQ
Sbjct: 2869 IIIKRKRGRPRKYPVETTLKMKDDSKTDTGIVTVEQSPSSSKLKVMQTDESNKETANLQE 2928
Query: 386 TMQQAQKHTEMITT--LKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKS 443
E I T ++ R+ K S + + + + K SV V +K
Sbjct: 2929 RSISNDDGEEKIVTSVRRRGRKPKRSLTVSDDAESSEPERKRQ------KSVSDPVEDKK 2982
Query: 444 LAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKT 477
E + EE + + E SKT
Sbjct: 2983 EQESDEEEEEEEEDEPSGATTRSTTRSEAQRSKT 3016
Score = 34.7 bits (78), Expect = 0.22
Identities = 52/264 (19%), Positives = 104/264 (39%), Gaps = 36/264 (13%)
Query: 109 EVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTA 168
E +KE +S E T E K+ +K + + + + G + + +E+ + +
Sbjct: 823 ENNKKERRLSAEKTKAEHKSRRSSDSK-IQKDSLGSKQHGITLQRRSESYSEDKCDMDST 881
Query: 169 TASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPK 228
NLK E + K + R K + + + + + KSK +G++ K +
Sbjct: 882 NMDSNLK----------PEEVVHKEKRRTKSLLE------EKLVLKSKSKTQGKQVKVVE 925
Query: 229 KQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKR----KNLAKTGV-----TSTSDSEEEG 279
+ ++ Q KP KE + +E E + K K +TGV T++S +
Sbjct: 926 TELQEGATKQATTPKPDKEKNTEENDSEKQRKSKVEDKPFEETGVEPVLETASSSAHSTQ 985
Query: 280 DDQE-------GEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEG 332
D ++K K ++ + L H+ + K ++ + + + +G
Sbjct: 986 KDSSHRAKLPLAKEKYKSDKDSTSTRLERKLSDGHKSRSLKHSSKDIKKKDENKSDDKDG 1045
Query: 333 KKPEVKKVEKKRETS--MDSRLQR 354
K+ + EK R S M+ +L R
Sbjct: 1046 KEVD-SSHEKARGNSSLMEKKLSR 1068
>gi|4557509 cylicin 2 [Homo sapiens]
Length = 348
Score = 71.6 bits (174), Expect = 2e-12
Identities = 71/286 (24%), Positives = 127/286 (44%), Gaps = 43/286 (15%)
Query: 81 LWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDIT 140
L I P V ++++ K + VEV+ K + K+ E+K + +D T +
Sbjct: 81 LMRISERPSVYLAARRQPLKPTRT---VEVDSKAAEIGKKG---EDKTTQKDTTDS---- 130
Query: 141 TPKAARRGRK-RKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRP-- 197
++G+K K K +E + + S K ++G+ +ATE + K +
Sbjct: 131 -ESELKQGKKDSKKGKDIEKGKEEKLDAKKDSKKGKKDAEKGKDSATESEDEKGGAKKDN 189
Query: 198 KMVKQPCPSESDIITEED-------KSKKKGQEEKQP-----------KKQPKKDEEGQK 239
K K+ D TE + K KKG+++ + K KKDE+G+K
Sbjct: 190 KKDKKDSNKGKDSATESEGEKGGTEKDSKKGKKDSKKGKDSAIELQAVKADEKKDEDGKK 249
Query: 240 EEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHR 299
+ +K + D K+ KE++ +K+ K S++DS+ + D ++ KK T
Sbjct: 250 DANKGDESKDAKKDAKEIKKGKKDKKKP---SSTDSDSKDDVKKESKKDA------TKDA 300
Query: 300 RNMLKGQHEKEAADRKR--KQEEQMETEQQNKDEGKKPEVKKVEKK 343
+ + K EKE+AD K+ K+ + + ++ K KK E K +KK
Sbjct: 301 KKVAKKDTEKESADSKKDAKKNAKKDAKKDAKKNAKKDEKKDAKKK 346
Score = 61.6 bits (148), Expect = 2e-09
Identities = 58/233 (24%), Positives = 104/233 (44%), Gaps = 24/233 (10%)
Query: 93 SSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRK 152
S + K S D+E ++E +K+D+ K +D K D T +G +K
Sbjct: 132 SELKQGKKDSKKGKDIEKGKEEKLDAKKDS----KKGKKDAEKGKDSATESEDEKGGAKK 187
Query: 153 AEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIIT 212
K+ + + +AT S K ++ + + K +G+ ++ ++D
Sbjct: 188 DNKKDKKDSNKGKDSATESEGEKGGTEKD---SKKGKKDSKKGKDSAIELQAV-KADEKK 243
Query: 213 EED--KSKKKGQEEKQPKKQPKKDEEGQKEEDKP------RKEPDKKEGKKEVESKRKNL 264
+ED K KG E K KK K+ ++G+K++ KP K+ KKE KK+ K +
Sbjct: 244 DEDGKKDANKGDESKDAKKDAKEIKKGKKDKKKPSSTDSDSKDDVKKESKKDATKDAKKV 303
Query: 265 AKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRK 317
AK D+E+E D + + K+ ++ + ++N K EK+ A +K K
Sbjct: 304 AK------KDTEKESADSKKDAKKNAKKDAKKDAKKNAKK--DEKKDAKKKGK 348
Score = 53.9 bits (128), Expect = 4e-07
Identities = 50/162 (30%), Positives = 81/162 (50%), Gaps = 16/162 (9%)
Query: 201 KQPCPSESDIITEEDKSKK-----KGQEEK-QPKKQPKK-DEEGQKEEDKPRKEPDKKEG 253
K SES++ + SKK KG+EEK KK KK ++ +K +D + D+K G
Sbjct: 125 KDTTDSESELKQGKKDSKKGKDIEKGKEEKLDAKKDSKKGKKDAEKGKDSATESEDEKGG 184
Query: 254 KKEVESKRKNLAKTGVTSTSDSE-----EEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHE 308
K+ K K + G S ++SE E D ++G+K K G++ +A +K E
Sbjct: 185 AKKDNKKDKKDSNKGKDSATESEGEKGGTEKDSKKGKKDSKKGKD--SAIELQAVKAD-E 241
Query: 309 KEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDS 350
K+ D K+ + E++ KD K+ + K +KK+ +S DS
Sbjct: 242 KKDEDGKKDANKGDESKDAKKD-AKEIKKGKKDKKKPSSTDS 282
Score = 36.2 bits (82), Expect = 0.076
Identities = 69/350 (19%), Positives = 134/350 (38%), Gaps = 99/350 (28%)
Query: 191 PKPRGRPKMVKQPCPSE--SDIITEEDKSKKKGQEEKQPK---KQPKKDEEGQKEEDKPR 245
PKP+ RP ++ PS+ + ++ D+ + +G + +QP + + E R
Sbjct: 38 PKPQ-RPGTKRRSKPSQIRDNTVSIIDEEQLRG-DRRQPLWMYRSLMRISERPSVYLAAR 95
Query: 246 KEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKG 305
++P K EV+SK + K G D + D + E + K G+
Sbjct: 96 RQPLKPTRTVEVDSKAAEIGKKG----EDKTTQKDTTDSESELKQGK------------- 138
Query: 306 QHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKI 365
+ K+ D ++ +EE+++ ++ +K +GKK EK ++++ +S + K K
Sbjct: 139 KDSKKGKDIEKGKEEKLDAKKDSK-KGKKD----AEKGKDSATESE------DEKGGAKK 187
Query: 366 DNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKN 425
DN +K NK K+
Sbjct: 188 DN----------------------------------------------KKDKKDSNKGKD 201
Query: 426 MFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQ 485
EG+ T+ +++ K K KKG + +E + + +
Sbjct: 202 SATESEGEKGGTE------------KDSKKGKKDSKKGKDSAIELQAVKADEKKDEDGKK 249
Query: 486 DGNQPQHNGESNEDSKDNHEA-STKKKPSSEERET-----EISLKDSTLD 529
D N+ + ++ +D+K+ + KKKPSS + ++ + S KD+T D
Sbjct: 250 DANKGDESKDAKKDAKEIKKGKKDKKKPSSTDSDSKDDVKKESKKDATKD 299
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 69.7 bits (169), Expect = 6e-12
Identities = 46/177 (25%), Positives = 91/177 (51%), Gaps = 5/177 (2%)
Query: 213 EEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTST 272
+++K K+K +E + +++ +K+ E Q++E + ++ +K+ KK+ E K++ +
Sbjct: 60 KKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKE 119
Query: 273 SDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEG 332
E + Q E+KRK R + R K + ++E +KRK+EE+ + ++N+ E
Sbjct: 120 RKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKER 179
Query: 333 KKPEVKKV--EKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTM 387
KK +K E+K+E + R ++ E K K D ++ L E A +VT+
Sbjct: 180 KKERERKERRERKKERKKERRKKK---ERKKDRKTDRQTDSQVFRPLRESAFNRVTV 233
Score = 58.9 bits (141), Expect = 1e-08
Identities = 43/156 (27%), Positives = 77/156 (49%), Gaps = 12/156 (7%)
Query: 206 SESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLA 265
+E +++ SK Q E + KK+ ++ E+ ++E +K RK ++ GKKE + ++K
Sbjct: 15 TELQMVSCSHISKPCTQRESERKKERREREKRKREREKERK---RERGKKEKKKRKKR-- 69
Query: 266 KTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKR-KQEEQMET 324
E E +E EK+RK R + R+ K + K+ R+R K++E+ E
Sbjct: 70 ------ERGKERERKRKEREKQRKERREKERRKRKKEKKKRERKQRGRRERKKKKERKER 123
Query: 325 EQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIK 360
E++NK ++ K+ +KKR +R E K
Sbjct: 124 ERENKQRRERKRKKRRKKKRRKERKREKERGKRERK 159
Score = 53.9 bits (128), Expect = 4e-07
Identities = 52/247 (21%), Positives = 105/247 (42%), Gaps = 27/247 (10%)
Query: 90 VKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGR 149
VK S +AA K + V +SK T E + E + R R
Sbjct: 2 VKAISSRAAVKLNTELQMVSCSH----ISKPCTQRESERKKE-----------RREREKR 46
Query: 150 KRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESD 209
KR+ EK+ + E K KR + + + K + R K K+ E
Sbjct: 47 KREREKERKRERGK-----------KEKKKRKKRERGKERERKRKEREKQRKERREKERR 95
Query: 210 IITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGV 269
+E K +++ Q ++ +K+ K+ +E ++E + R+ KK KK+ +RK + G
Sbjct: 96 KRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGK 155
Query: 270 TSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQ-EEQMETEQQN 328
+ + +++E +++R + R+ + + E++ RK+K+ ++ +T++Q
Sbjct: 156 RERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQT 215
Query: 329 KDEGKKP 335
+ +P
Sbjct: 216 DSQVFRP 222
Score = 33.9 bits (76), Expect = 0.38
Identities = 42/216 (19%), Positives = 86/216 (39%), Gaps = 35/216 (16%)
Query: 306 QHEKEAADRKRKQEEQM-ETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLK 364
Q E E +R++E++ E E++ K E K E KK KKRE + +R E + +
Sbjct: 31 QRESERKKERREREKRKREREKERKRERGKKEKKK-RKKRERGKERERKRKEREKQRKER 89
Query: 365 IDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFK 424
+ R ++ +K E ++ R+ K + E+ + K
Sbjct: 90 REKERRKR---------------KKEKKKRERKQRGRRERKKKKERKERERENKQRRERK 134
Query: 425 NMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDA 484
K ++++ +E + K++GK+ +K K++ K +
Sbjct: 135 R----------------KKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRE--RNR 176
Query: 485 QDGNQPQHNGESNEDSKDNHEASTKKKPSSEERETE 520
++ + + E E K+ + KKK ++R+T+
Sbjct: 177 KERKKERERKERRERKKERKKERRKKKERKKDRKTD 212
Score = 32.0 bits (71), Expect = 1.4
Identities = 30/115 (26%), Positives = 48/115 (41%), Gaps = 18/115 (15%)
Query: 255 KEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLK------GQHE 308
K + S+ T + S S + E +RK R + +R K G+ E
Sbjct: 3 KAISSRAAVKLNTELQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKE 62
Query: 309 K---------EAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQR 354
K + +RKRK+ E+ E++ K+ K+ KK +KKRE R +R
Sbjct: 63 KKKRKKRERGKERERKRKEREKQRKERREKERRKR---KKEKKKRERKQRGRRER 114
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 68.6 bits (166), Expect = 1e-11
Identities = 93/475 (19%), Positives = 197/475 (41%), Gaps = 59/475 (12%)
Query: 81 LWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDIT 140
L ++D K + +A K SN ++ E T+ +E D E K ++ + A+++
Sbjct: 158 LVKVDAKTKAQLDEWKAKKKASNGNARPETV---TNDDEEALDEETKRRDQMIKGAIEVL 214
Query: 141 -----------TPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVK 189
+ ++ RK+K EK+ + V+P P T+
Sbjct: 215 IREYSSELNAPSQESDSHPRKKKKEKKEDIFR-----------RFPVAPLIPYPLITKED 263
Query: 190 I---PKPRGRPKMVKQPCPSESDIIT--EEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKP 244
I + ++ + D EE+K KK ++E+Q ++ +++ E ++E ++
Sbjct: 264 INAIEMEEDKRDLISREISKFRDTHKKLEEEKGKK--EKERQEIEKERRERERERERERE 321
Query: 245 RKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLK 304
R+E +++ ++ K K + + D++ +++R R+ + + RN +
Sbjct: 322 RREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDR 381
Query: 305 GQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLK 364
+ +++ DR+R++E + E E++ + E ++ ++ E++RE + +R E
Sbjct: 382 SRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREE------ 435
Query: 365 IDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRF-KVSQVIMEKSTMLYNKF 423
D D + +L + Q+ K+ E I KK R + K ++ E+ + +
Sbjct: 436 -DEEDAYERRKLERKLREKEAAYQERLKNWE-IRERKKTREYEKEAEREEERRREMAKEA 493
Query: 424 KNM--FLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKG-PNKKLEKEQTGSKTLNG 480
K + FL D + A Q++ + K + ++ +K E E+ + L
Sbjct: 494 KRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAE 553
Query: 481 G------------SDAQDGNQPQ--HNGESNEDSKDNHEASTKK-KPSSEERETE 520
G +A+ QPQ ES E+ ++ E K+ +P EE E E
Sbjct: 554 GHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPE 608
Score = 40.0 bits (92), Expect = 0.005
Identities = 57/261 (21%), Positives = 107/261 (40%), Gaps = 38/261 (14%)
Query: 112 EKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATAS 171
EK +E E+ + + + + R R+R+ +K+ + EE
Sbjct: 386 EKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRK 445
Query: 172 VNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKK-- 229
+ K+ R + AA + ++ R + K+ E + EE++ ++ +E K+ K+
Sbjct: 446 LERKL---REKEAAYQERLKNWEIRER--KKTREYEKEAEREEERRREMAKEAKRLKEFL 500
Query: 230 --------QPK-----------KDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVT 270
PK +D E + E D E D+K K+E+E R+ L G
Sbjct: 501 EDYDDDRDDPKYYRGSALQKRLRDREKEMEAD----ERDRKREKEELEEIRQRLLAEGHP 556
Query: 271 STSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKD 330
D+E + +QE E++R+ Q + + EK+ + KR EE ME E++ +
Sbjct: 557 DP-DAELQRMEQEAERRRQP----QIKQEPESEEEEEEKQEKEEKR--EEPMEEEEEPEQ 609
Query: 331 EG-KKPEVKKVEKKRETSMDS 350
+ KP ++ + S S
Sbjct: 610 KPCLKPTLRPISSAPSVSSAS 630
Score = 33.1 bits (74), Expect = 0.65
Identities = 42/223 (18%), Positives = 95/223 (42%), Gaps = 34/223 (15%)
Query: 61 YSENKEKYGKPNKRKGFNEGL--WEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVS 118
Y K + K + E L WEI K + ++A + EE+ ++
Sbjct: 441 YERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAERE----------EERRREMA 490
Query: 119 KEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSP 178
KE +E + D + +A + R R EK++E +E
Sbjct: 491 KEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADER--------------DR 536
Query: 179 KRGRPAATEVKIPKPRGRPKMVKQPCPS-ESDIITEEDKSKKKGQEEKQPKKQPKKDEEG 237
KR + E+ R +++ + P ++++ E +++++ Q + + + + +++EE
Sbjct: 537 KREKEELEEI-------RQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEEEEEE 589
Query: 238 QKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGD 280
++E+++ R+EP ++E + E + K + ++ S S G+
Sbjct: 590 KQEKEEKREEPMEEEEEPEQKPCLKPTLRPISSAPSVSSASGN 632
>gi|239508778 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 123
Score = 68.6 bits (166), Expect = 1e-11
Identities = 38/127 (29%), Positives = 71/127 (55%), Gaps = 12/127 (9%)
Query: 228 KKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKK 287
KK+ KK E + EE + +E ++KEGK++ + K K K T ++E+ + +E EKK
Sbjct: 2 KKKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKK 61
Query: 288 RKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETS 347
RK +R K + E+E + ++EE+ E E++ K+EG++ + KK +++E
Sbjct: 62 RK--------RKRKKKKEEEERE----EEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEE 109
Query: 348 MDSRLQR 354
+ + +R
Sbjct: 110 EEKKKKR 116
Score = 60.1 bits (144), Expect = 5e-09
Identities = 37/132 (28%), Positives = 72/132 (54%), Gaps = 21/132 (15%)
Query: 212 TEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTS 271
TEE + ++ +E++ +K+ +K++ +KE+ K KE +K++ K+E E KRK K
Sbjct: 13 TEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKK---- 68
Query: 272 TSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDE 331
EEE +++E E++ + K + EKE R++K++++ E++ +E
Sbjct: 69 -KKEEEEREEEEEEEEEE--------------KEEEEKEEGRRRKKKKKRRRKEEE--EE 111
Query: 332 GKKPEVKKVEKK 343
KK +K +KK
Sbjct: 112 KKKKRRRKTKKK 123
Score = 58.5 bits (140), Expect = 1e-08
Identities = 34/124 (27%), Positives = 72/124 (58%), Gaps = 3/124 (2%)
Query: 196 RPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKK 255
+ K K+ +E TEE++ K+ ++EK+ +K+ +K+++ + +E + RKE +++E K+
Sbjct: 3 KKKKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEEKKR 62
Query: 256 EVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRK 315
+ + K+K K + EEE +++E E+K +G R + RR + + +K+ RK
Sbjct: 63 KRKRKKK---KEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKKKRRRK 119
Query: 316 RKQE 319
K++
Sbjct: 120 TKKK 123
Score = 46.6 bits (109), Expect = 6e-05
Identities = 36/141 (25%), Positives = 70/141 (49%), Gaps = 23/141 (16%)
Query: 149 RKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSES 208
+K+K +K ETEE T + K G+ + K + + K K+
Sbjct: 2 KKKKKKK--ETEE-----TEETEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKE------ 48
Query: 209 DIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTG 268
E + +K+ +E+K+ +K+ KK EE ++EE++ +E +K+E +KE +RK K
Sbjct: 49 ----TEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKK-- 102
Query: 269 VTSTSDSEEEGDDQEGEKKRK 289
+EE ++++ +++RK
Sbjct: 103 ----RRRKEEEEEKKKKRRRK 119
Score = 45.4 bits (106), Expect = 1e-04
Identities = 31/115 (26%), Positives = 59/115 (51%), Gaps = 3/115 (2%)
Query: 150 KRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESD 209
K+K +K+ ETEE T T K ++ + + K + + K+ E +
Sbjct: 1 KKKKKKKKETEETEE-TEETEEEEEKEGKRKEKRKEKRKEKEKKKKTKETEKRKEKEEEE 59
Query: 210 IITEEDKSKKKGQEEKQPKKQPKKD--EEGQKEEDKPRKEPDKKEGKKEVESKRK 262
+ + KKK +EE++ +++ +++ EE +KEE + RK+ K+ K+E E K+K
Sbjct: 60 KKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKKRRRKEEEEEKKK 114
Score = 40.8 bits (94), Expect = 0.003
Identities = 33/141 (23%), Positives = 66/141 (46%), Gaps = 26/141 (18%)
Query: 111 EEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATA 170
+E E + E+T+ EE+ + K R+ ++++ EK+ +T+E
Sbjct: 8 KETEETEETEETEEEEEKEGK----------RKEKRKEKRKEKEKKKKTKE--------- 48
Query: 171 SVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITE-EDKSKKKGQEEKQPKK 229
+ KR E K + R + K ++ E + E E++ K++G+ K+ KK
Sbjct: 49 ------TEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEKEEGRRRKKKKK 102
Query: 230 QPKKDEEGQKEEDKPRKEPDK 250
+ +K+EE +K++ + RK K
Sbjct: 103 RRRKEEEEEKKKKRRRKTKKK 123
Score = 37.4 bits (85), Expect = 0.034
Identities = 33/150 (22%), Positives = 69/150 (46%), Gaps = 35/150 (23%)
Query: 111 EEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATA 170
E +ET ++E + EEK K R+ ++++ EK+ +T+E
Sbjct: 9 ETEETEETEETEEEEEKEGKR-----------KEKRKEKRKEKEKKKKTKE--------- 48
Query: 171 SVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQ 230
+ KR E K + R + K ++ E EE++ +K+ +E+++ +++
Sbjct: 49 ------TEKRKEKEEEEKKRKRKRKKKKEEEEREEEE-----EEEEEEKEEEEKEEGRRR 97
Query: 231 PKKDEEGQKEEDKPRKEPDKKEGKKEVESK 260
KK + +KEE+ E KK+ +++ + K
Sbjct: 98 KKKKKRRRKEEE----EEKKKKRRRKTKKK 123
Score = 32.7 bits (73), Expect = 0.84
Identities = 26/103 (25%), Positives = 46/103 (44%), Gaps = 17/103 (16%)
Query: 63 ENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETS----VS 118
E +EK GK +++ K K ++ TK++ + E EEK+
Sbjct: 21 EEEEKEGKRKEKR-----------KEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKK 69
Query: 119 KEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEE 161
KE+ + EE+ E+ K + + RR +K+K ++ E EE
Sbjct: 70 KEEEEREEEEEEEEEEKEEE--EKEEGRRRKKKKKRRRKEEEE 110
Score = 32.0 bits (71), Expect = 1.4
Identities = 16/79 (20%), Positives = 36/79 (45%)
Query: 442 KSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQPQHNGESNEDSK 501
K ++++ E+ KTK+ K+ ++ EK++ + + ++ + + E E+ K
Sbjct: 32 KRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEEK 91
Query: 502 DNHEASTKKKPSSEERETE 520
+ KKK + E E
Sbjct: 92 EEGRRRKKKKKRRRKEEEE 110
Score = 30.4 bits (67), Expect = 4.2
Identities = 19/79 (24%), Positives = 32/79 (40%), Gaps = 4/79 (5%)
Query: 446 EQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQPQHNGESNEDSKDNHE 505
E+R+ + K K + K K+ EKE+ K ++ + + E E+ K+ E
Sbjct: 31 EKRKEKRKEKEKKKKTKETEKRKEKEEEEKKRKRKRKKKKEEEEREEEEEEEEEEKEEEE 90
Query: 506 AS----TKKKPSSEERETE 520
KKK +E E
Sbjct: 91 KEEGRRRKKKKKRRRKEEE 109
Score = 29.6 bits (65), Expect = 7.1
Identities = 20/80 (25%), Positives = 35/80 (43%), Gaps = 7/80 (8%)
Query: 442 KSLAEQRQHEEANKTKDQGKK-GPNKKLEKEQTGSKTLNGGSDAQDGNQPQHNGESNEDS 500
K E + EE +T+++ +K G K+ KE+ K + + + + E+
Sbjct: 5 KKKKETEETEETEETEEEEEKEGKRKEKRKEKRKEK------EKKKKTKETEKRKEKEEE 58
Query: 501 KDNHEASTKKKPSSEERETE 520
+ + KKK EERE E
Sbjct: 59 EKKRKRKRKKKKEEEEREEE 78
>gi|153945728 microtubule-associated protein 1B [Homo sapiens]
Length = 2468
Score = 68.2 bits (165), Expect = 2e-11
Identities = 63/276 (22%), Positives = 115/276 (41%), Gaps = 27/276 (9%)
Query: 95 QQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAE 154
+Q KQ A S ++ + + E K +VTK + P + E
Sbjct: 531 KQTKLKQ-RADSRESLKPAAKPLPSKSVRKESKEETPEVTKVNHVEKPP-----KVESKE 584
Query: 155 KQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRG---RPKMVKQPCPSESDII 211
K + ++ + T SV K P + P+ + ++ + + +PK K+ + +
Sbjct: 585 KVMVKKDKPIKTETKPSVTEKEVPSKEEPSPVKAEVAEKQATDVKPKAAKEKTVKKETKV 644
Query: 212 TEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTS 271
EDK ++K + +K+ K K+D+ K+E+KP+KE KKE KKE++ + K K V
Sbjct: 645 KPEDKKEEKEKPKKEVAK--KEDKTPIKKEEKPKKEEVKKEVKKEIKKEEKKEPKKEVKK 702
Query: 272 TSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDE 331
+ +E + + E+K++ + EKE +K + + E
Sbjct: 703 ETPPKEVKKEVKKEEKKE--------------VKKEEKEPKKEIKKLPKDAKKSSTPLSE 748
Query: 332 GKKPEV--KKVEKKRETSMDSRLQRIHAEIKNSLKI 365
KKP KV KK E+ + + K +K+
Sbjct: 749 AKKPAALKPKVPKKEESVKKDSVAAGKPKEKGKIKV 784
Score = 59.3 bits (142), Expect = 8e-09
Identities = 56/201 (27%), Positives = 89/201 (44%), Gaps = 27/201 (13%)
Query: 89 KVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRG 148
K + + +QA + A+ + V+ KET V ED E++ ++V K D T K +
Sbjct: 617 KAEVAEKQATDVKPKAAKEKTVK-KETKVKPEDKKEEKEKPKKEVAKKEDKTPIKKEEKP 675
Query: 149 RKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSES 208
+K + +K+V+ E K PK+ EVK P PK VK+
Sbjct: 676 KKEEVKKEVKKE---------IKKEEKKEPKK------EVKKETP---PKEVKK------ 711
Query: 209 DIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTG 268
++ EE K KK EEK+PKK+ KK + K+ P E K K K++ K
Sbjct: 712 EVKKEEKKEVKK--EEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKKEESVKKD 769
Query: 269 VTSTSDSEEEGDDQEGEKKRK 289
+ +E+G + +K+ K
Sbjct: 770 SVAAGKPKEKGKIKVIKKEGK 790
Score = 41.2 bits (95), Expect = 0.002
Identities = 71/342 (20%), Positives = 124/342 (36%), Gaps = 71/342 (20%)
Query: 55 PKDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPK-VKFSSQQAATKQSNASSDVEVEEK 113
PK++ + +K K +K E EI PK K SS + + A+ +V +K
Sbjct: 706 PKEV---KKEVKKEEKKEVKKEEKEPKKEIKKLPKDAKKSSTPLSEAKKPAALKPKVPKK 762
Query: 114 ETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVN 173
E SV K+ + K +G+ + +K+ + EA T +
Sbjct: 763 EESVKKDS-----------------VAAGKPKEKGKIKVIKKEGKAAEAVAAAVGTGATT 805
Query: 174 LKVSPKRGRPAATEVK--------IPKPRGRPKMVKQPCPSESDIITE--------EDKS 217
V G A K + P K ++ E D+ + ED+
Sbjct: 806 AAVMAAAGIAAIGPAKELEAERSLMSSPEDLTKDFEELKAEEVDVTKDIKPQLELIEDEE 865
Query: 218 KKKG---------QEEKQPKKQPKK---------DEEGQKEEDKPRKEPDKKEGKKEVES 259
K K Q+E++ K P + + EG+ E+ EP +K+G ++E
Sbjct: 866 KLKETEPVEAYVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEK 925
Query: 260 KRKNLAKTGVTS-TSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADR--KR 316
A +S T D EE+ + +E E+ + G +H +A +
Sbjct: 926 FEDEGAGFEESSETGDYEEKAETEEAEEPEEDGE-------------EHVCVSASKHSPT 972
Query: 317 KQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAE 358
+ EE + E K+ V + + E MD +++ AE
Sbjct: 973 EDEESAKAEADAYIREKRESVASGDDRAEEDMDEAIEKGEAE 1014
Score = 32.7 bits (73), Expect = 0.84
Identities = 45/186 (24%), Positives = 74/186 (39%), Gaps = 27/186 (14%)
Query: 55 PKDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKE 114
PK + KE KP +K E PK ++ A K+ E + K+
Sbjct: 630 PKAAKEKTVKKETKVKPEDKK-------EEKEKPK-----KEVAKKEDKTPIKKEEKPKK 677
Query: 115 TSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQ-VETEEAGVVTTATASVN 173
V KE +K ++ K V TP + +K EK+ V+ EE
Sbjct: 678 EEVKKEVKKEIKKEEKKEPKKEVKKETPPKEVKKEVKKEEKKEVKKEE------KEPKKE 731
Query: 174 LKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEED----KSKKKGQEEKQPKK 229
+K PK + ++T + K +P +K P + + + ++ K K+KG + K KK
Sbjct: 732 IKKLPKDAKKSSTPLSEAK---KPAALKPKVPKKEESVKKDSVAAGKPKEKG-KIKVIKK 787
Query: 230 QPKKDE 235
+ K E
Sbjct: 788 EGKAAE 793
Score = 31.2 bits (69), Expect = 2.5
Identities = 60/273 (21%), Positives = 105/273 (38%), Gaps = 47/273 (17%)
Query: 61 YSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETS---V 117
Y KE+ + +EG+ + + + + ++ + D+E E E +
Sbjct: 876 YVIQKEREVTKGPAESPDEGITTTEGEGECEQTPEELEPVEKQGVDDIEKFEDEGAGFEE 935
Query: 118 SKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVS 177
S E D+EEKA E+ AE+ E E V +A+ K S
Sbjct: 936 SSETGDYEEKAETEE--------------------AEEPEEDGEEHVCVSAS-----KHS 970
Query: 178 PKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSK--KKGQEEKQPKKQPKKDE 235
P +A R + + V + D EED + +KG+ E+ ++ ++D+
Sbjct: 971 PTEDEESAKAEADAYIREKRESV-----ASGDDRAEEDMDEAIEKGEAEQSEEEADEEDK 1025
Query: 236 EGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKG----G 291
E++ EP+K E + V + A+ G +EE+ K+ G G
Sbjct: 1026 AEDAREEE--YEPEKMEAEDYVMAVVDKAAEAG-----GAEEQYGFLTTPTKQLGAQSPG 1078
Query: 292 RNFQTAHRRNMLKGQHEKEA-ADRKRKQEEQME 323
R ++ L G E EA A + +E+Q E
Sbjct: 1079 REPASSIHDETLPGGSESEATASDEENREDQPE 1111
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 67.8 bits (164), Expect = 2e-11
Identities = 57/236 (24%), Positives = 111/236 (47%), Gaps = 32/236 (13%)
Query: 109 EVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTA 168
E+ E+E + +T E K E K K R KRK E++ E +
Sbjct: 37 EIREREREI---ETRKEGKKERESERK-------KERREREKRKREREKERKR------- 79
Query: 169 TASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEK-QP 227
+RG+ + + R R K ++ E + E++K KKK ++E+ +
Sbjct: 80 ----------ERGKKEKKGERKKEERERKKRRREKENKEGE---EKEKRKKKEKKERGRT 126
Query: 228 KKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKK 287
K+ K+ E ++ + + RKE ++K+ ++E E +RK K + EEE ++E +++
Sbjct: 127 SKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKER 186
Query: 288 RKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKK 343
+K RN + + K + E++ +RK+K+E + E ++ + ++ E K E+K
Sbjct: 187 KKRERNRKERKKERERKERRERK-KERKKKEERKKERQKDRQTNWREKERGKRERK 241
Score = 67.4 bits (163), Expect = 3e-11
Identities = 39/142 (27%), Positives = 77/142 (54%), Gaps = 5/142 (3%)
Query: 213 EEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTST 272
E +K +K+ + +K+ K + KK+E +E K R+E + KEG+++ + K+K + G TS
Sbjct: 72 EREKERKRERGKKEKKGERKKEE---RERKKRRREKENKEGEEKEKRKKKEKKERGRTSK 128
Query: 273 SDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEG 332
E E ++ ++RK + R + + E++ +RK+ E++ E +++ + E
Sbjct: 129 EGKERERKEERKREERK--ERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKER 186
Query: 333 KKPEVKKVEKKRETSMDSRLQR 354
KK E + E+K+E R +R
Sbjct: 187 KKRERNRKERKKERERKERRER 208
Score = 66.6 bits (161), Expect = 5e-11
Identities = 42/152 (27%), Positives = 87/152 (57%), Gaps = 12/152 (7%)
Query: 213 EEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTST 272
E+++ +++G++EK K + KK+E +E K R+E + KEG+++ + K+K + G TS
Sbjct: 74 EKERKRERGKKEK--KGERKKEE---RERKKRRREKENKEGEEKEKRKKKEKKERGRTS- 127
Query: 273 SDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEG 332
+EG ++E +++RK R + R + + E+E +RK+++ +Q+ +++ + E
Sbjct: 128 ----KEGKERERKEERK--REERKERERKKEEREKERERKERKKRERKQVGEKEEERKEK 181
Query: 333 KKPEVKKVEKKRETSMDSRLQRIHAEIKNSLK 364
++ E KK E+ R+ R ++ E K K
Sbjct: 182 ERKERKKRERNRKERKKERERKERRERKKERK 213
Score = 65.9 bits (159), Expect = 9e-11
Identities = 49/167 (29%), Positives = 84/167 (50%), Gaps = 9/167 (5%)
Query: 192 KPRGRPKMVKQPCPSESDIITEEDKSKKKGQ---EEKQPKKQPKKDEEGQKEEDKPRKEP 248
+ + R + K+ E + E K +KKG+ EE++ KK+ ++ E + EE + RK+
Sbjct: 59 RKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKK 118
Query: 249 DKKE----GKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKK-RKGGRNFQTAHRRNML 303
+KKE K+ E +RK K + ++E ++E E+K RK Q +
Sbjct: 119 EKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEER 178
Query: 304 KGQHEKEAADRKR-KQEEQMETEQQNKDEGKKPEVKKVEKKRETSMD 349
K + KE R+R ++E + E E++ + E KK KK E+K+E D
Sbjct: 179 KEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKD 225
Score = 63.5 bits (153), Expect = 4e-10
Identities = 43/166 (25%), Positives = 87/166 (52%), Gaps = 5/166 (3%)
Query: 190 IPKPRGRPKMVKQPCPSESDIIT-EEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEP 248
I KP +P + E +I T +E K +++ + +K+ +++ K+ E +KE + R +
Sbjct: 25 ISKPCTQPGWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKK 84
Query: 249 DKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHE 308
+KK +K+ E +RK K + EE + ++ ++K++ GR + R + +
Sbjct: 85 EKKGERKKEERERK---KRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKR 141
Query: 309 KEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQR 354
+E +R+RK+EE+ E E++ K+ K+ + EK+ E R +R
Sbjct: 142 EERKERERKKEER-EKERERKERKKRERKQVGEKEEERKEKERKER 186
Score = 60.8 bits (146), Expect = 3e-09
Identities = 58/244 (23%), Positives = 106/244 (43%), Gaps = 30/244 (12%)
Query: 101 QSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETE 160
Q S++ E+E KE E ++ + R RKR+ EK+ + E
Sbjct: 31 QPGWQSEIREREREIETRKEGKKERESERKKE----------RREREKRKREREKERKRE 80
Query: 161 EAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKK 220
+ KR R + K + + K K+ + + E K ++K
Sbjct: 81 RGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERK 140
Query: 221 GQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKE-GKKEVESKRKNLAKTGVTSTSDSEEEG 279
+E K+ ++ KK+E ++ E K RK+ ++K+ G+KE E K K + +E
Sbjct: 141 REERKE--RERKKEEREKERERKERKKRERKQVGEKEEERKEK-----------ERKERK 187
Query: 280 DDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKK 339
+ K+RK R + RR K + +KE +RK+++++ +T + K+ GK+ +K
Sbjct: 188 KRERNRKERKKER--ERKERRERKKERKKKE--ERKKERQKDRQTNWREKERGKRE--RK 241
Query: 340 VEKK 343
KK
Sbjct: 242 ERKK 245
Score = 32.7 bits (73), Expect = 0.84
Identities = 35/214 (16%), Positives = 85/214 (39%), Gaps = 22/214 (10%)
Query: 308 EKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDN 367
+ E +R+R+ E + E +++ + E KK ++ ++KRE + + +R E K K +
Sbjct: 35 QSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEE 94
Query: 368 LDVNRCIEALDELASLQVTMQQAQKHTEMITTLK--KIRRFKVSQVIMEKSTMLYNKFKN 425
+ + + + ++ ++ E T K K R K + E+
Sbjct: 95 RERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERK--------- 145
Query: 426 MFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQ 485
+ K E+ + + K +++ + G ++ KE+ + + +
Sbjct: 146 -----------ERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRK 194
Query: 486 DGNQPQHNGESNEDSKDNHEASTKKKPSSEERET 519
+ + + E E K+ + +KK ++R+T
Sbjct: 195 ERKKERERKERRERKKERKKKEERKKERQKDRQT 228
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 66.6 bits (161), Expect = 5e-11
Identities = 95/470 (20%), Positives = 198/470 (42%), Gaps = 33/470 (7%)
Query: 65 KEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEK--ETSVSKEDT 122
K K K NK+ +E + DN+ K+K S+ ++ +S SD ++ + + K
Sbjct: 151 KGKAQKSNKKWDGSEE--DEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKP 208
Query: 123 DHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGR 182
++ NED + I T + +K + K+ + E+A + + K + G+
Sbjct: 209 GPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKL-----RKLKEKEELETGK 263
Query: 183 PAATEVKIPKPRGRPKMVKQPCPSESDII-TEEDKSKKKGQEEKQPKKQPKKDEEGQKEE 241
++ K + + + VK ++ +I E+K++ E + KK ++ +K+
Sbjct: 264 KDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKG 323
Query: 242 DKPRKEPDKKEG--KKEVESKRKNLAKTGVTSTSDSEEEGDD----QEGEKKRKGGRNFQ 295
+K KE +KK+G K V++ ++ LAK EE + +E E KRK +
Sbjct: 324 EKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLE 383
Query: 296 TAHRRNMLKGQHEKEAADRKRKQ-----EEQMETEQQNKDEGKKPEVKKVEKKRETSMDS 350
R K Q EKE +R +K+ + Q E + + K + + VE + S+
Sbjct: 384 QEKRER--KKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSKDSLPK 441
Query: 351 RLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQ 410
+ + I+ + K L+ E+++ A+++V Q + E ++
Sbjct: 442 K-RPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEEDTED 500
Query: 411 VIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEK 470
++ + + + + EG+ V +V K E+ + EE + +D+ + E+
Sbjct: 501 AGLDDWEAMASDEETEKV--EGNKVHIEV--KENPEEEEEEEEEEEEDE-----ESEEEE 551
Query: 471 EQTGSKTLNGGSDAQDGNQPQHNGESNEDSKDNHEASTKKKPSSEERETE 520
E+ G + G + + + + D K + E S+ + S++ T+
Sbjct: 552 EEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTK 601
Score = 59.7 bits (143), Expect = 6e-09
Identities = 73/349 (20%), Positives = 144/349 (41%), Gaps = 16/349 (4%)
Query: 58 IFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSV 117
+ P SE EK P + NEG + + K K ++ ++ S V+ + ++
Sbjct: 291 VIPASE--EKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEAL 348
Query: 118 SK-EDTDHEEKASNEDVTKAVDITTPKAARRGR----KRKAEKQVETEEAGVVTTATASV 172
+K ++ + +K E+ K ++ K R KR+ +KQ E E + +
Sbjct: 349 AKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLL 408
Query: 173 NLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPK 232
R R AT +K+ + +G K P + I EDK +KK ++ + K+ +
Sbjct: 409 TKSQREARARAEAT-LKLLQAQGVEVPSKDSLPKKRPIY--EDKKRKKIPQQLESKEVSE 465
Query: 233 KDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGR 292
E E + P+K+E VE + + T D E D+E EK
Sbjct: 466 SMELCAAVEVMEQGVPEKEETPPPVEPEEEE--DTEDAGLDDWEAMASDEETEKVEGNKV 523
Query: 293 NFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRL 352
+ + + + E+E D + ++EE+ E E + + ++ E EK ++D +
Sbjct: 524 HIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKP 583
Query: 353 QRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLK 401
+ E+ + + D+ D E + A ++ ++ + H++ + T K
Sbjct: 584 SK---EMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLE-HSKNVNTEK 628
Score = 51.2 bits (121), Expect = 2e-06
Identities = 82/397 (20%), Positives = 153/397 (38%), Gaps = 61/397 (15%)
Query: 148 GRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSE 207
G+K+K + + T++ + A + G AA E + K +G+ K K+ +
Sbjct: 2 GKKQKNKSEDSTKDDIDLDALAAEI-------EGAGAAKEQEPQKSKGKKKKEKKKQDFD 54
Query: 208 SDIITEE-------------------DKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEP 248
D I +E K + +EE K + KK ++G+K+ +
Sbjct: 55 EDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQS----FDD 110
Query: 249 DKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHE 308
+ E ++ +SK K AK V S S+++ D + KK KG + G E
Sbjct: 111 NDSEELEDKDSKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKG----KAQKSNKKWDGSEE 166
Query: 309 KEAADRKRKQEEQMETEQQNKDEGKK-PEVKKVEKKRETSMDS-RLQRIHAEIKNSLKID 366
E +K K+ ++ + ++ DE + + +K +KK + + ++ + + S KI
Sbjct: 167 DEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNIESGNEDDDASFKIK 226
Query: 367 NLDVNRCIEALDELASL---QVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKF 423
+ + + E + +++ ++ E+ T K + K SQ E+ T+
Sbjct: 227 TVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETV----- 281
Query: 424 KNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSD 483
K+ V G ++ ++ E +K K KK +K EKE+ K
Sbjct: 282 KSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKK------- 334
Query: 484 AQDGNQPQHNGESNEDSKDNHEASTKKKPSSEERETE 520
G S K EA K K E ++ E
Sbjct: 335 ----------GPSKATVKAMQEALAKLKEEEERQKRE 361
>gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]
Length = 290
Score = 65.9 bits (159), Expect = 9e-11
Identities = 51/227 (22%), Positives = 107/227 (47%), Gaps = 19/227 (8%)
Query: 120 EDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPK 179
+D D +++ D + T K R RKR E++ + +E ++ +
Sbjct: 70 KDADGDDRQRERDRVRE---KTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDRE 126
Query: 180 RGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQE-EKQPKKQPKKDEEGQ 238
R + E + + RGR + + E + TE+D+ ++ E E++ ++ +K +E +
Sbjct: 127 REKQKGRERE--RDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKERE 184
Query: 239 KEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAH 298
E D+ R+ +KE +++ + +R K T + D+EGE+ +T
Sbjct: 185 TERDRDRQRDTEKERERQTDRERDRQRK-----TQTERQRETDREGER--------ETDR 231
Query: 299 RRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRE 345
RR + + + DR+R ++E+ + E++ + + ++ E KK EK+RE
Sbjct: 232 RRERQRDRDRGKERDRERDRKEERKKERKKERKKERKEKKKEEKRRE 278
Score = 50.1 bits (118), Expect = 5e-06
Identities = 42/179 (23%), Positives = 84/179 (46%), Gaps = 20/179 (11%)
Query: 187 EVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRK 246
EV IP R ++ Q P + ++ K + + +++ + E+ +KE D+ RK
Sbjct: 42 EVTIPLDFSRGRLGSQESPRSWGL----GQAHKDADGDDRQRERDRVREKTEKERDRDRK 97
Query: 247 EPDKKEGKKEVESKRKNLAKTGVTSTSDSEEE-----------GDDQEGEKKRKGGRNFQ 295
D++ +KE E+ R + D E E G ++E ++ R+ R Q
Sbjct: 98 R-DRERRRKEKETNRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDREKERERQ 156
Query: 296 TAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQR 354
T R+ + + DR+R+++++ ETE +D ++ + +K E++R+T + QR
Sbjct: 157 TEKDRDGQRETETERERDREREKQKERETE---RDRDRQRDTEK-ERERQTDRERDRQR 211
Score = 47.4 bits (111), Expect = 3e-05
Identities = 50/205 (24%), Positives = 89/205 (43%), Gaps = 39/205 (19%)
Query: 100 KQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVET 159
K++N + D EK+T + + D + E++ E + D + R R+++ E+Q E
Sbjct: 107 KETNRNRD---REKQTEIER-DREREKQKGRE---RERDRGRERERDRDREKERERQTEK 159
Query: 160 EEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKK 219
+ G T T R R E + + R R + ++ ++D E D+ +K
Sbjct: 160 DRDGQRETETERER-----DREREKQKERETERDRDRQRDTEKERERQTD--RERDRQRK 212
Query: 220 -----------KGQEEKQPKKQPKKDEEGQKEEDKPR--KEPDKKEGKKEVESKRKNLAK 266
+G+ E +++ ++D + KE D+ R KE KKE KKE + +RK K
Sbjct: 213 TQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKERKEKKK 272
Query: 267 TGVTSTSDSEEEGDDQEGEKKRKGG 291
+ + +KKRK G
Sbjct: 273 E------------EKRREDKKRKWG 285
Score = 44.7 bits (104), Expect = 2e-04
Identities = 37/176 (21%), Positives = 84/176 (47%), Gaps = 17/176 (9%)
Query: 192 KPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKK 251
+ R R + K+ + + ++ + ++ + EKQ ++ ++D ++E D+ R+ K
Sbjct: 96 RKRDRERRRKEKETNRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDRE----K 151
Query: 252 EGKKEVESKRKNLAKTGVTSTSDSE-EEGDDQEGEKKRKGGRNFQTAHRR--NMLKGQHE 308
E +++ E R +T D E E+ ++E E+ R R+ + R + + +
Sbjct: 152 ERERQTEKDRDGQRETETERERDREREKQKERETERDRDRQRDTEKERERQTDRERDRQR 211
Query: 309 KEAADRKRKQEEQMETE-------QQNKDEGK---KPEVKKVEKKRETSMDSRLQR 354
K +R+R+ + + E E Q+++D GK + +K E+K+E + + +R
Sbjct: 212 KTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKER 267
Score = 40.8 bits (94), Expect = 0.003
Identities = 41/194 (21%), Positives = 81/194 (41%), Gaps = 35/194 (18%)
Query: 63 ENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVE-EKETSVSKED 121
E +++ G+ +R E E D + + + Q + ++ E E ++E KE
Sbjct: 126 EREKQKGRERERDRGRER--ERDRDREKERERQTEKDRDGQRETETERERDREREKQKER 183
Query: 122 TDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRG 181
++ D K + T + R RK + E+Q ET+ G +R
Sbjct: 184 ETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREG---------------ERE 228
Query: 182 RPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSK-KKGQEEKQPKKQPKKDEEGQKE 240
E + + RG+ E D+ + +K + +K+ KK+ KK+ + +K+
Sbjct: 229 TDRRRERQRDRDRGK----------------ERDRERDRKEERKKERKKERKKERKEKKK 272
Query: 241 EDKPRKEPDKKEGK 254
E+K R++ +K G+
Sbjct: 273 EEKRREDKKRKWGE 286
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 64.7 bits (156), Expect = 2e-10
Identities = 63/298 (21%), Positives = 126/298 (42%), Gaps = 41/298 (13%)
Query: 54 GPKDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEK 113
G K++ E K++ G+ ++K +G + + N +++ ++ + D E EE+
Sbjct: 692 GEKELAEKEEWKKRDGEEQEQKEREQG-HQKERNQEMEEGGEEEHGEGEEEEGDREEEEE 750
Query: 114 ETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVN 173
+ KE+ + EE + + +RK E++ EE G
Sbjct: 751 KEGEGKEEGEGEEVEGEREKEEG-------------ERKKEERAGKEEKG---------- 787
Query: 174 LKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKK 233
+ G E + + RG K E + + + KG+ E++ ++ +
Sbjct: 788 ----EEEGDQGEGEEEETEGRGEEK-------EEGGEVEGGEVEEGKGEREEEEEEGEGE 836
Query: 234 DEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRN 293
+EEG+ EE++ E ++ EGK E E + + G + EEE + EGE++ +G
Sbjct: 837 EEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEGEGE 896
Query: 294 FQTAHRRNMLKGQHEKEAADRKRKQEEQME------TEQQNKDEGKKPEVKKVEKKRE 345
+ +G+ E E + + K EE+ E E++ + EG+ E + E++ E
Sbjct: 897 EEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGE 954
Score = 63.9 bits (154), Expect = 3e-10
Identities = 81/323 (25%), Positives = 142/323 (43%), Gaps = 61/323 (18%)
Query: 47 THETAFLGPKDIFPYSENKE-KYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNAS 105
T +TA D Y E E K GK K+ ++G+ F +Q A T ++ +
Sbjct: 533 TQDTALTENDDSDEYEEMSEMKEGKACKQH-VSQGI----------FMTQPATTIEAFSD 581
Query: 106 SDVEV-EEKETSVSKEDTDHEEKA--SNEDVTKAVDITTPKAARRGRKRKAEKQVE--TE 160
+VE+ EEKE + + EE+ +NE+ K GRK K E + T+
Sbjct: 582 EEVEIPEEKEGAEDSKGNGIEEQEVEANEENVKV---------HGGRKEKTEILSDDLTD 632
Query: 161 EAGVVTTATASVNLKVSPKRGRPAAT---------------EVKIPKPRGRPKMVKQPCP 205
+A V SV GR T K K +GR +M ++P
Sbjct: 633 KAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEM-ERPGE 691
Query: 206 SESDIITEEDKSKKKGQEEKQPKK------QPKKDEEGQKEEDKPRKEPDKKEGKKEVES 259
E ++ +E+ K+ G E+Q +K Q ++++E ++ ++ E +++EG +E E
Sbjct: 692 GEKELAEKEEWKKRDG--EEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEE 749
Query: 260 KRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQE 319
+++ K E EG++ EGE++++ G + KG+ E D+ +E
Sbjct: 750 EKEGEGK--------EEGEGEEVEGEREKEEGERKKEERAGKEEKGEEE---GDQGEGEE 798
Query: 320 EQMETEQQNKDEGKKPEVKKVEK 342
E+ E + K+EG + E +VE+
Sbjct: 799 EETEGRGEEKEEGGEVEGGEVEE 821
Score = 52.8 bits (125), Expect = 8e-07
Identities = 66/278 (23%), Positives = 114/278 (41%), Gaps = 34/278 (12%)
Query: 86 NNPKVKFSSQQAATKQSNA---SSDVEVEEKETSVSKEDTDH--EEKASNEDVTKAVDIT 140
N +K S Q KQ + D + E + S E+ E KA + V++ + +T
Sbjct: 511 NEKSLKLSPVQKQKKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMT 570
Query: 141 TPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMV 200
P + E ++ E+ G + + + A E + GR
Sbjct: 571 QPATTIEAFSDE-EVEIPEEKEGAEDSKGNGI------EEQEVEANEENVKVHGGR---- 619
Query: 201 KQPCPSESDIITE-----EDKSKKKGQEEKQPK-------KQPKKDEEGQKEEDKPRKEP 248
K+ SD +T+ E K+K G+ E P+ ++ E ++E++ + E
Sbjct: 620 KEKTEILSDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEK 679
Query: 249 DKKEGKKEVESK-RKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQH 307
DK G+ E + K LA+ D EE+ + +E E+ + RN + G+
Sbjct: 680 DKGRGEMERPGEGEKELAEKEEWKKRDGEEQ-EQKEREQGHQKERNQEMEEGGEEEHGEG 738
Query: 308 EKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRE 345
E+E DR EE+ E E + K+EG+ EV+ +K E
Sbjct: 739 EEEEGDR----EEEEEKEGEGKEEGEGEEVEGEREKEE 772
Score = 50.8 bits (120), Expect = 3e-06
Identities = 33/142 (23%), Positives = 73/142 (51%), Gaps = 9/142 (6%)
Query: 213 EEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTST 272
EE+ + +G+ E++ + +D EG+ EE++ E +++EG+ E E + + + G
Sbjct: 922 EEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEG 981
Query: 273 SDSEEEGD------DQEGEKKRKG---GRNFQTAHRRNMLKGQHEKEAADRKRKQEEQME 323
+ E EG+ ++EGE++ +G G ++G+ E E + + ++EE E
Sbjct: 982 EEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEE 1041
Query: 324 TEQQNKDEGKKPEVKKVEKKRE 345
++ + EG+ E ++ ++ E
Sbjct: 1042 EGEEREKEGEGEENRRNREEEE 1063
Score = 48.9 bits (115), Expect = 1e-05
Identities = 32/132 (24%), Positives = 66/132 (50%), Gaps = 10/132 (7%)
Query: 214 EDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTS 273
E++ + +G+EE+ K ++ EEG+ E ++ E + ++G+ E E +
Sbjct: 905 EEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEG 964
Query: 274 DSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGK 333
+ EEEG+ + E + +G +G+ E E + + + EE+ E E++ + EG+
Sbjct: 965 EGEEEGEGEGEEGEGEGEEE----------EGEGEGEEEEGEEEGEEEGEGEEEGEGEGE 1014
Query: 334 KPEVKKVEKKRE 345
+ E +VE + E
Sbjct: 1015 EEEEGEVEGEVE 1026
Score = 47.4 bits (111), Expect = 3e-05
Identities = 37/152 (24%), Positives = 76/152 (50%), Gaps = 10/152 (6%)
Query: 213 EEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLA--KTGVT 270
EE++ + KG+EE + + ++EEG+ E + E +++EG+ E E + + G
Sbjct: 913 EEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEG 972
Query: 271 STSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEE-QMETE---Q 326
+ E EG+++EGE G + +G+ E+E ++EE ++E E +
Sbjct: 973 EGEEGEGEGEEEEGE----GEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGE 1028
Query: 327 QNKDEGKKPEVKKVEKKRETSMDSRLQRIHAE 358
+ + EG++ E ++ ++RE + R + E
Sbjct: 1029 EGEGEGEEEEGEEEGEEREKEGEGEENRRNRE 1060
Score = 46.6 bits (109), Expect = 6e-05
Identities = 34/140 (24%), Positives = 75/140 (53%), Gaps = 17/140 (12%)
Query: 213 EEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTST 272
EE++ + +G+EE + + + + EG+ EE++ E +++EG++E E + + + G
Sbjct: 958 EEEEGEGEGEEEGEGEGE---EGEGEGEEEEGEGEGEEEEGEEEGEEEGEG-EEEGEGEG 1013
Query: 273 SDSEE-------EGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETE 325
+ EE EG++ EGE + + G + +G+ E+ +R+ ++EE+ + +
Sbjct: 1014 EEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREK---EGEGEENRRNREEEEEEEGKYQ 1070
Query: 326 QQNKDEGKK---PEVKKVEK 342
+ ++E ++ E KKV K
Sbjct: 1071 ETGEEENERQDGEEYKKVSK 1090
Score = 45.4 bits (106), Expect = 1e-04
Identities = 40/152 (26%), Positives = 73/152 (48%), Gaps = 37/152 (24%)
Query: 213 EEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTST 272
EE++ + +G+EE+ + + +EEG+ EE+ + +++EG+ E E + G
Sbjct: 982 EEEEGEGEGEEEEG---EEEGEEEGEGEEEGEGEGEEEEEGEVEGEVE-------GEEGE 1031
Query: 273 SDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEG 332
+ EEE ++EGE++ K G E E R R++EE+ +EG
Sbjct: 1032 GEGEEEEGEEEGEEREKEG----------------EGEENRRNREEEEE--------EEG 1067
Query: 333 KKPEVKKVEKKRETSMDSRLQRIHAEIKNSLK 364
K E + E +R+ D + ++IK S+K
Sbjct: 1068 KYQETGEEENERQ---DGEEYKKVSKIKGSVK 1096
Score = 37.7 bits (86), Expect = 0.026
Identities = 64/314 (20%), Positives = 122/314 (38%), Gaps = 26/314 (8%)
Query: 213 EEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEV-ESKRKNLAKTGVTS 271
E+ K ++E + ++ K G+KE K D K EV E K K++ +
Sbjct: 594 EDSKGNGIEEQEVEANEENVKVHGGRKE--KTEILSDDLTDKAEVSEGKAKSVGEA---- 647
Query: 272 TSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQE---EQMETEQQN 328
D E D E+ G ++Q R KG+ +K + +R E E E E+
Sbjct: 648 -EDGPEGRGDGTCEEGSSGAEHWQDEERE---KGEKDKGRGEMERPGEGEKELAEKEEWK 703
Query: 329 KDEGKKPEVKKVE----KKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQ 384
K +G++ E K+ E K+R M+ + H E + + + E +E +
Sbjct: 704 KRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEE 763
Query: 385 VTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSL 444
V ++ ++ E KK R + E+ + + GE +V +
Sbjct: 764 VEGEREKEEGER----KKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEV 819
Query: 445 AEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQPQHNGESNEDSKDNH 504
E + E + + +G++ + E+E G + G ++G + GE E+ ++
Sbjct: 820 EEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEE----GEGEEEGEEGE 875
Query: 505 EASTKKKPSSEERE 518
+++ E E
Sbjct: 876 GEGEEEEGEGEGEE 889
Score = 37.4 bits (85), Expect = 0.034
Identities = 30/131 (22%), Positives = 67/131 (51%), Gaps = 17/131 (12%)
Query: 214 EDKSKKKGQEEKQPKKQPK---KDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVT 270
E++ + +G+EE++ + + + ++ EG+ EE++ +E +++E + E E R+N +
Sbjct: 1006 EEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREE---- 1061
Query: 271 STSDSEEEGDDQ---EGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQ 327
+ EEEG Q E E +R+ G ++ + +KG K + +++ T+
Sbjct: 1062 ---EEEEEGKYQETGEEENERQDGEEYKKVSK---IKGS-VKYGKHKTYQKKSVTNTQGN 1114
Query: 328 NKDEGKKPEVK 338
K++ K V+
Sbjct: 1115 GKEQRSKMPVQ 1125
Score = 35.0 bits (79), Expect = 0.17
Identities = 29/136 (21%), Positives = 67/136 (49%), Gaps = 8/136 (5%)
Query: 214 EDKSKKKGQEEKQPKKQPKKDEEGQKEED----KPRKEPDKKEGKKEVESKRKNLAKTGV 269
E++ +++G+ E++ + + +++EEG+ E + + E +++EG++E E + K G
Sbjct: 996 EEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKE--GEGE 1053
Query: 270 TSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNK 329
+ + EEE +++EG+ + G + K K + + + Q ++ +
Sbjct: 1054 ENRRNREEE-EEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQ 1112
Query: 330 DEGKKPEVK-KVEKKR 344
GK+ K V+ KR
Sbjct: 1113 GNGKEQRSKMPVQSKR 1128
Score = 34.3 bits (77), Expect = 0.29
Identities = 18/66 (27%), Positives = 37/66 (56%), Gaps = 1/66 (1%)
Query: 213 EEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTST 272
EE++ ++ +EE++ K Q +EE ++++ + K+ K +G + K K K VT+T
Sbjct: 1053 EENRRNREEEEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKY-GKHKTYQKKSVTNT 1111
Query: 273 SDSEEE 278
+ +E
Sbjct: 1112 QGNGKE 1117
>gi|104526627 triadin [Homo sapiens]
Length = 729
Score = 64.7 bits (156), Expect = 2e-10
Identities = 99/481 (20%), Positives = 188/481 (39%), Gaps = 96/481 (19%)
Query: 89 KVKFSSQQAATKQSNASSDVEVEEKE-TSVSKEDTDHEEKASNEDVTKAVDI-------- 139
KVK ++ + Q S E E+KE +VSK HE+K +DI
Sbjct: 229 KVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSK----HEQKDQYAFCRYMIDIFVHGDLKP 284
Query: 140 ----------TTPKAAR-----------RGRKRKAEKQVETEEAGVVTTATASVNLKVSP 178
T +A+R G K+KAEK+V +E T ++K
Sbjct: 285 GQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSE-----TKKKEKEDIKKKS 339
Query: 179 KRGRPAATEVKIPKPRGRPKM----VKQPCPSESDIITEEDKSKKKGQEEKQPK--KQPK 232
++ E K P K + ++ D E+ K KK E +QPK KQ K
Sbjct: 340 EKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEK 399
Query: 233 KDE--EGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDD----QEGEK 286
K++ E K K P K+ K + E ++ + + ++E ++ +
Sbjct: 400 KEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIR 459
Query: 287 KRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGK--KPEVKKVEKKR 344
K K G+ + +KG+ EK A K K+ E + E+ +K GK KP+ +++ K+
Sbjct: 460 KEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSK-AGKEVKPKPPQLQGKK 518
Query: 345 ETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIR 404
E + ++++ E K ++ + + +++ ++ + T+ + ++ LK+++
Sbjct: 519 EEKPEPQIKK---EAKPAIS-EKVQIHK-----QDIVKPEKTVSHGKPEEKV---LKQVK 566
Query: 405 RFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGP 464
+ + K T AE R+ E + D+ K P
Sbjct: 567 AVTIEKTAKPKPT-------------------------KKAEHREREPPSIKTDKPKPTP 601
Query: 465 NKKLEKEQTG-SKTLNGGSDAQDGNQPQHNGE----SNEDSKDNHEASTKKKPSSEERET 519
E ++G KT ++++ +H E + ++S H + +KP+ ++
Sbjct: 602 KGTSEVTESGKKKTEISEKESKEKADMKHLREEKVSTRKESLQLHNVTKAEKPARVSKDV 661
Query: 520 E 520
E
Sbjct: 662 E 662
Score = 59.7 bits (143), Expect = 6e-09
Identities = 76/333 (22%), Positives = 142/333 (42%), Gaps = 35/333 (10%)
Query: 62 SENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEK--ETSVSK 119
SE K+K + K+K E +++ K S + T + A + + +EK ++ +K
Sbjct: 325 SETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTK 384
Query: 120 EDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNL-KVSP 178
+ + E+ + K + K+ ++ ++KQV+ + T A + VS
Sbjct: 385 KPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAK------TERAKEEIGAVSI 438
Query: 179 KRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQP----KKQP--K 232
K+ P E K K ++ K+ S I+ +DK KG+EEK P +K+P K
Sbjct: 439 KKAVPGKKEEKTTK-TVEQEIRKEKSGKTSSIL--KDKEPIKGKEEKVPASLKEKEPETK 495
Query: 233 KDEEGQKEEDKPRKEPDKKEGKKEVE-------------SKRKNLAKTGVTSTSDSEEEG 279
KDE+ K + + +P + +GKKE + S++ + K + + G
Sbjct: 496 KDEKMSKAGKEVKPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHG 555
Query: 280 DDQEGEKKR-KGGRNFQTAHRRNMLKGQH-EKEAADRK--RKQEEQMETEQQNKDEGKKP 335
+E K+ K +TA + K +H E+E K + + T + + KK
Sbjct: 556 KPEEKVLKQVKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKT 615
Query: 336 EVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNL 368
E+ + E K + M + + K SL++ N+
Sbjct: 616 EISEKESKEKADMKHLREEKVSTRKESLQLHNV 648
Score = 53.9 bits (128), Expect = 4e-07
Identities = 81/412 (19%), Positives = 159/412 (38%), Gaps = 38/412 (9%)
Query: 71 PNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASN 130
P ++K ++ E P+ K ++ ++ V +EK + E+K
Sbjct: 137 PLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKP 196
Query: 131 EDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKI 190
E T A + K A + ++ ++ ++ V TA ++ +P + + + K
Sbjct: 197 ETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKA 256
Query: 191 PKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKP---RKE 247
+ K C DI D K GQ P P ++ + P KE
Sbjct: 257 AVSKHEQKDQYAFCRYMIDIFVHGD--LKPGQSPAIPPPLP-TEQASRPTPASPALEEKE 313
Query: 248 PDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQH 307
+KK+ +K+V S+ K K + S+ E D EKK G + + K
Sbjct: 314 GEKKKAEKKVTSETKKKEKEDIKKKSEKETAID---VEKKEPG--------KASETKQGT 362
Query: 308 EKEAADRKRKQEEQMETEQQNKD--EGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKI 365
K AA K++E+ E ++ K E ++P+ KK EKK + ++ + ++S+
Sbjct: 363 VKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAK----SPKKEHSVPS 418
Query: 366 DNLDVNRCIEALDELASLQVTMQQAQKHTEMIT-----TLKKIRRFKVSQVIMEKSTMLY 420
D + A +E+ ++ + K E T ++K + K S ++ +K
Sbjct: 419 DKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEP--- 475
Query: 421 NKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQ 472
+ G+ + V + K ++ + + K+ K P + +KE+
Sbjct: 476 -------IKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEE 520
Score = 52.4 bits (124), Expect = 1e-06
Identities = 99/452 (21%), Positives = 173/452 (38%), Gaps = 89/452 (19%)
Query: 123 DHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGR 182
D E+ +ED K P + K K EKQ + E + KV+ K
Sbjct: 118 DEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPER---------KIQTKVTHKE-- 166
Query: 183 PAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEED 242
K +G+ K+ ++ P E +E KK+ E K K+ KK + +K E+
Sbjct: 167 ---------KEKGKEKVREKEKP-EKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEE 216
Query: 243 KPRKE--PDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRR 300
K +KE K+E K+ +K K + K T +E +D+E K + Q A R
Sbjct: 217 KTKKEVKGGKQEKVKQTAAKVKEVQK-----TPSKPKEKEDKEKAAVSKHEQKDQYAFCR 271
Query: 301 NML---------KGQ-----------------------HEKEAADRKRKQEEQMETEQQN 328
M+ GQ EKE +K +++ ET+++
Sbjct: 272 YMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKE 331
Query: 329 KDEGKKPEVKK----VEKKR-----ETSMDS-RLQRIHAEIKNSLKIDNLDVNRCIEALD 378
K++ KK K+ VEKK ET + ++ A K+ K D+ + E
Sbjct: 332 KEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQ 391
Query: 379 ELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFL----VGEGDS 434
Q ++ +KH E + KK + + K+ + + + G+ +
Sbjct: 392 PKGKKQ---EKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEE 448
Query: 435 VITQVLNKSLAEQRQHEEANKTKD----QGK--KGPNKKLEKE---QTGSKTLNGGSDAQ 485
T+ + + + +++ + ++ KD +GK K P EKE + K G + +
Sbjct: 449 KTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVK 508
Query: 486 DGNQPQHNGESNEDSKDNHEASTKKKPSSEER 517
PQ G+ E K + + KP+ E+
Sbjct: 509 P-KPPQLQGKKEE--KPEPQIKKEAKPAISEK 537
Score = 50.8 bits (120), Expect = 3e-06
Identities = 97/473 (20%), Positives = 187/473 (39%), Gaps = 45/473 (9%)
Query: 70 KPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKAS 129
KP K+ E + E P+ K +++ K A E +KE K++ + A
Sbjct: 179 KPEKKATHKEKI-EKKEKPETKTLAKEQK-KAKTAEKSEEKTKKEVKGGKQEKVKQTAAK 236
Query: 130 NEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVK 189
++V K + PK + +++ A + E ++ + + K G+ A
Sbjct: 237 VKEVQKTP--SKPKE-KEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPP 293
Query: 190 IPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEE---GQKEEDKPRK 246
+P + +P P+ + E+K +K + EK+ + KK E+ +K E +
Sbjct: 294 LPT-----EQASRPTPASPAL---EEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAI 345
Query: 247 EPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQ 306
+ +KKE K E+K + K + + +E+ +D +K +K Q ++ K +
Sbjct: 346 DVEKKEPGKASETK-QGTVKIAAQAAAKKDEKKED--SKKTKKPAEVEQPKGKKQEKKEK 402
Query: 307 HEKEAADRKRKQEEQMETEQQNKDEGKKPEVKKVE-------KKRETSMDSRLQRIHAEI 359
H + A K++ + + + K E K E+ V KK E + + Q I E
Sbjct: 403 HVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKE- 461
Query: 360 KNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTML 419
K+ L I+ +E +V +K E T K + K + + K L
Sbjct: 462 KSGKTSSILKDKEPIKGKEE----KVPASLKEKEPE---TKKDEKMSKAGKEVKPKPPQL 514
Query: 420 YNKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEK--EQTGSKT 477
K + + + I + +++E+ Q + + K + K EK +Q + T
Sbjct: 515 QGKKEE-----KPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVT 569
Query: 478 LNGGSDAQDGNQPQHNGESNEDSKDNHEASTKKKPS----SEERETEISLKDS 526
+ + + + +H K + T K S S +++TEIS K+S
Sbjct: 570 IEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKES 622
Score = 43.9 bits (102), Expect = 4e-04
Identities = 70/325 (21%), Positives = 133/325 (40%), Gaps = 34/325 (10%)
Query: 213 EEDKSKKKGQEEKQPKKQPK---KDEEGQKEEDKPRKEPDKKEGKKE-VESKRKNLAKTG 268
E K K + QE+ + K Q K K++E KE+ + +++P+KK KE +E K K KT
Sbjct: 142 EIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTL 201
Query: 269 VTSTSDSEEEGDDQEGEKKR-KGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQ 327
++ +E KK KGG+ Q + + K K+ ++ ++ +
Sbjct: 202 AKEQKKAKTAEKSEEKTKKEVKGGK-------------QEKVKQTAAKVKEVQKTPSKPK 248
Query: 328 NKDEGKKPEVKKVEKKRETSMDSRLQRI--HAEIKNSLK------IDNLDVNRCIEALDE 379
K++ +K V K E+K + + + I H ++K + +R A
Sbjct: 249 EKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPA 308
Query: 380 LASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQV 439
L + ++A+K T K+ K EK T + + K E ++
Sbjct: 309 LEEKEGEKKKAEKKVTSETKKKEKEDIKKKS---EKETAIDVEKKEPGKASETKQGTVKI 365
Query: 440 LNKSLAEQ-RQHEEANKTKD--QGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQPQHNGES 496
++ A++ + E++ KTK + ++ KK EK++ + +
Sbjct: 366 AAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAK 425
Query: 497 NEDSKDNHEASTKKK--PSSEERET 519
E +K+ A + KK P +E +T
Sbjct: 426 TERAKEEIGAVSIKKAVPGKKEEKT 450
Score = 35.0 bits (79), Expect = 0.17
Identities = 46/219 (21%), Positives = 87/219 (39%), Gaps = 22/219 (10%)
Query: 95 QQAATKQSNASSDVEVEEKETSVSKEDT-------DHEEKASNEDVTKAVDITTPKAAR- 146
+Q K+ + + +++KE KE+ E +E ++KA PK +
Sbjct: 455 EQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQL 514
Query: 147 RGRKR-KAEKQVETEEAGVVTTATAS-----VNLKVSPKRGRPAATEVKIPKPRGRPKMV 200
+G+K K E Q++ E ++ V + + G+P +K K K
Sbjct: 515 QGKKEEKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKAVTIEKTA 574
Query: 201 KQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKK----- 255
K +++ E S K + + PK + E G+K+ + KE +K K
Sbjct: 575 KPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKEKADMKHLREE 634
Query: 256 EVESKRKNLAKTGVTSTSDS---EEEGDDQEGEKKRKGG 291
+V +++++L VT ++ +D KK K G
Sbjct: 635 KVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEG 673
Score = 30.8 bits (68), Expect = 3.2
Identities = 50/243 (20%), Positives = 87/243 (35%), Gaps = 27/243 (11%)
Query: 65 KEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDV--EVEEKETSVSKEDT 122
KEK GK + E + + ++ TK+ S EV+ K + +
Sbjct: 460 KEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKE 519
Query: 123 DHEEKASNEDVTKAV---------DITTP-KAARRGR-KRKAEKQVETEEAGVVTTATAS 171
+ E ++ A+ DI P K G+ + K KQV+ + TA
Sbjct: 520 EKPEPQIKKEAKPAISEKVQIHKQDIVKPEKTVSHGKPEEKVLKQVKA--VTIEKTAKPK 577
Query: 172 VNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQP 231
K + P + +K KP+ P P + +TE K K + E++ +K
Sbjct: 578 PTKKAEHREREPPS--IKTDKPK--------PTPKGTSEVTESGKKKTEISEKESKEKAD 627
Query: 232 KKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGG 291
K ++E+ RKE + + E + S +EG + K+K
Sbjct: 628 MKHL--REEKVSTRKESLQLHNVTKAEKPARVSKDVEDVPASKKAKEGTEDVSPTKQKSP 685
Query: 292 RNF 294
+F
Sbjct: 686 ISF 688
>gi|120953300 leucine-rich repeats and IQ motif containing 1 isoform
1 [Homo sapiens]
Length = 1722
Score = 63.5 bits (153), Expect = 4e-10
Identities = 105/454 (23%), Positives = 193/454 (42%), Gaps = 35/454 (7%)
Query: 89 KVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRG 148
KV+ + KQ + E+ ++E ++ HEE N + + T K +
Sbjct: 215 KVEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEK 274
Query: 149 RKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSES 208
K KQ + A V + K G +++ K + + K E+
Sbjct: 275 EKNSLLKQQNNAAVKIQAKYKAFVAYQ---KYGPIIKEQIESKKRKAQEWKEK-----EA 326
Query: 209 DIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNL-AKT 267
I +E++++K+ +EE++ K++ KK QKEE++ R+E + +E K V+ +R+ L +K
Sbjct: 327 KIRQKEEENRKRLEEEQRIKEERKK----QKEEERKRREKEYEEKKNIVKQEREQLISKE 382
Query: 268 GVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQM---ET 324
+ D+ ++ KK + + KG K D K++E +
Sbjct: 383 KIILREDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLV 442
Query: 325 EQQNKDEGKKPEV---KKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELA 381
E+ N E + + ++ K + S+ S Q I A+ K K +NL RC E EL
Sbjct: 443 EESNMKENVDRQTILKESIQVKLKESISS--QTILADFKMEEKNENLAKKRCSE---ELV 497
Query: 382 SLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNM-FLVGEGDSVITQVL 440
+ + TE+ + K K + E + + K M ++ E TQ++
Sbjct: 498 KQERKYENTDNKTELGNSDLK-GNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQII 556
Query: 441 ---NKSLAEQRQHEEANKTKDQGKKGPNKKLEKE--QTGSKTLNGGSDAQDGNQPQHN-G 494
N+ ++E + +EE KD +K +K+EKE Q + L D + Q +
Sbjct: 557 LGHNQEISEVKTNEEQKIIKDNQQK-KIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLS 615
Query: 495 ESNEDSKDNHE--ASTKKKPSSEERETEISLKDS 526
++E+SKD E +K+ S+ +E E + KD+
Sbjct: 616 LTSENSKDVRENVILQEKEIYSKSKEIEENPKDN 649
Score = 33.9 bits (76), Expect = 0.38
Identities = 56/272 (20%), Positives = 104/272 (38%), Gaps = 66/272 (24%)
Query: 251 KEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKE 310
+E +KE+E K K K + D EE+ +E EK+ + F+ EK+
Sbjct: 175 QEKQKELEDKEKQTLK----AQRDREEKQFQEEEEKRHCWMKQFKV-----------EKK 219
Query: 311 AADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDV 370
+ +KQE+ ++ K+E K+ K++ + ++ +H +++
Sbjct: 220 KLENIQKQEQDKMNDELYKEE-------KIWKEKFKQHEEYIRNLHLQMEE--------- 263
Query: 371 NRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVG 430
+ T + Q+ E + LK+ V K+ + Y K+
Sbjct: 264 -------------ERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKY------- 303
Query: 431 EGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQP 490
G + Q+ +K Q E+ K + Q ++ K+LE+EQ ++ +
Sbjct: 304 -GPIIKEQIESKKRKAQEWKEKEAKIR-QKEEENRKRLEEEQR----------IKEERKK 351
Query: 491 QHNGESNEDSKDNHEASTKKKPSSEERETEIS 522
Q E K+ E KK +ERE IS
Sbjct: 352 QKEEERKRREKEYEE---KKNIVKQEREQLIS 380
Score = 33.1 bits (74), Expect = 0.65
Identities = 60/271 (22%), Positives = 109/271 (40%), Gaps = 43/271 (15%)
Query: 214 EDKSKKKGQEEKQPKKQPKKDEEGQ--KEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTS 271
++K K+ +EKQ K + EE Q +EE+K + K+ K E + K +N+ K
Sbjct: 175 QEKQKELEDKEKQTLKAQRDREEKQFQEEEEK--RHCWMKQFKVE-KKKLENIQKQEQDK 231
Query: 272 TSD---SEEEGDDQEGEKKRKGGRN--FQTAHRRNMLKGQHEKEAADRKRKQ-------- 318
+D EE+ ++ ++ + RN Q R K Q EKE ++Q
Sbjct: 232 MNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQ 291
Query: 319 ----------------EEQMETEQQNKDEGKKPEVKKVEKKRETSMD-SRLQRIHAEIKN 361
+EQ+E++++ E K+ E K +K+ E QRI E K
Sbjct: 292 AKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKK 351
Query: 362 SLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYN 421
+ + + E + Q+ ++I+ K I R SQ ++ S + +
Sbjct: 352 QKEEERKRREKEYEEKKNIVK--------QEREQLISKEKIILREDASQQLIISSALKKS 403
Query: 422 KFKNMFLVGEGDSVITQVLNKSLAEQRQHEE 452
+ N L E S + K+L ++ ++
Sbjct: 404 GYNNKHLSLEDISNDKGDIAKNLVDENSKKQ 434
>gi|120953243 leucine-rich repeats and IQ motif containing 1 isoform
2 [Homo sapiens]
Length = 1336
Score = 63.5 bits (153), Expect = 4e-10
Identities = 105/454 (23%), Positives = 193/454 (42%), Gaps = 35/454 (7%)
Query: 89 KVKFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRG 148
KV+ + KQ + E+ ++E ++ HEE N + + T K +
Sbjct: 215 KVEKKKLENIQKQEQDKMNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEK 274
Query: 149 RKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSES 208
K KQ + A V + K G +++ K + + K E+
Sbjct: 275 EKNSLLKQQNNAAVKIQAKYKAFVAYQ---KYGPIIKEQIESKKRKAQEWKEK-----EA 326
Query: 209 DIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNL-AKT 267
I +E++++K+ +EE++ K++ KK QKEE++ R+E + +E K V+ +R+ L +K
Sbjct: 327 KIRQKEEENRKRLEEEQRIKEERKK----QKEEERKRREKEYEEKKNIVKQEREQLISKE 382
Query: 268 GVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQM---ET 324
+ D+ ++ KK + + KG K D K++E +
Sbjct: 383 KIILREDASQQLIISSALKKSGYNNKHLSLEDISNDKGDIAKNLVDENSKKQEDVLLWLV 442
Query: 325 EQQNKDEGKKPEV---KKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELA 381
E+ N E + + ++ K + S+ S Q I A+ K K +NL RC E EL
Sbjct: 443 EESNMKENVDRQTILKESIQVKLKESISS--QTILADFKMEEKNENLAKKRCSE---ELV 497
Query: 382 SLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNM-FLVGEGDSVITQVL 440
+ + TE+ + K K + E + + K M ++ E TQ++
Sbjct: 498 KQERKYENTDNKTELGNSDLK-GNLKEQFPLQELKSDAQKEEKIMKHVINENTGQKTQII 556
Query: 441 ---NKSLAEQRQHEEANKTKDQGKKGPNKKLEKE--QTGSKTLNGGSDAQDGNQPQHN-G 494
N+ ++E + +EE KD +K +K+EKE Q + L D + Q +
Sbjct: 557 LGHNQEISEVKTNEEQKIIKDNQQK-KIQKVEKEEIQEQNGLLYKDKDTLVISVKQRSLS 615
Query: 495 ESNEDSKDNHE--ASTKKKPSSEERETEISLKDS 526
++E+SKD E +K+ S+ +E E + KD+
Sbjct: 616 LTSENSKDVRENVILQEKEIYSKSKEIEENPKDN 649
Score = 33.9 bits (76), Expect = 0.38
Identities = 56/272 (20%), Positives = 104/272 (38%), Gaps = 66/272 (24%)
Query: 251 KEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKE 310
+E +KE+E K K K + D EE+ +E EK+ + F+ EK+
Sbjct: 175 QEKQKELEDKEKQTLK----AQRDREEKQFQEEEEKRHCWMKQFKV-----------EKK 219
Query: 311 AADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLDV 370
+ +KQE+ ++ K+E K+ K++ + ++ +H +++
Sbjct: 220 KLENIQKQEQDKMNDELYKEE-------KIWKEKFKQHEEYIRNLHLQMEE--------- 263
Query: 371 NRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVG 430
+ T + Q+ E + LK+ V K+ + Y K+
Sbjct: 264 -------------ERTRFKDQQEKEKNSLLKQQNNAAVKIQAKYKAFVAYQKY------- 303
Query: 431 EGDSVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQP 490
G + Q+ +K Q E+ K + Q ++ K+LE+EQ ++ +
Sbjct: 304 -GPIIKEQIESKKRKAQEWKEKEAKIR-QKEEENRKRLEEEQR----------IKEERKK 351
Query: 491 QHNGESNEDSKDNHEASTKKKPSSEERETEIS 522
Q E K+ E KK +ERE IS
Sbjct: 352 QKEEERKRREKEYEE---KKNIVKQEREQLIS 380
Score = 33.1 bits (74), Expect = 0.65
Identities = 60/271 (22%), Positives = 109/271 (40%), Gaps = 43/271 (15%)
Query: 214 EDKSKKKGQEEKQPKKQPKKDEEGQ--KEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTS 271
++K K+ +EKQ K + EE Q +EE+K + K+ K E + K +N+ K
Sbjct: 175 QEKQKELEDKEKQTLKAQRDREEKQFQEEEEK--RHCWMKQFKVE-KKKLENIQKQEQDK 231
Query: 272 TSD---SEEEGDDQEGEKKRKGGRN--FQTAHRRNMLKGQHEKEAADRKRKQ-------- 318
+D EE+ ++ ++ + RN Q R K Q EKE ++Q
Sbjct: 232 MNDELYKEEKIWKEKFKQHEEYIRNLHLQMEEERTRFKDQQEKEKNSLLKQQNNAAVKIQ 291
Query: 319 ----------------EEQMETEQQNKDEGKKPEVKKVEKKRETSMD-SRLQRIHAEIKN 361
+EQ+E++++ E K+ E K +K+ E QRI E K
Sbjct: 292 AKYKAFVAYQKYGPIIKEQIESKKRKAQEWKEKEAKIRQKEEENRKRLEEEQRIKEERKK 351
Query: 362 SLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYN 421
+ + + E + Q+ ++I+ K I R SQ ++ S + +
Sbjct: 352 QKEEERKRREKEYEEKKNIVK--------QEREQLISKEKIILREDASQQLIISSALKKS 403
Query: 422 KFKNMFLVGEGDSVITQVLNKSLAEQRQHEE 452
+ N L E S + K+L ++ ++
Sbjct: 404 GYNNKHLSLEDISNDKGDIAKNLVDENSKKQ 434
>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
Length = 2817
Score = 63.5 bits (153), Expect = 4e-10
Identities = 69/310 (22%), Positives = 134/310 (43%), Gaps = 39/310 (12%)
Query: 91 KFSSQQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRK 150
KF + A + A + +EV+ E +D +E+ SN + KA+
Sbjct: 307 KFDNLDAEADEGWAGAQMEVDYTE---QLNFSDDDEQGSNSPKENNSEDQGSKASENNEN 363
Query: 151 RKAEKQVETEEAGVVTTATASVNLKV----SPKRGRPAATEVKIPKPRGRPKMVKQ---- 202
+K +V ++ A SV KV P + T +P P PK++ Q
Sbjct: 364 KKETDEVSNTKSSSQIPAQPSV-AKVPYGKGPSFNQERGTSSHLPPP---PKLLAQQHPP 419
Query: 203 -----------PCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKK 251
P PS+ + E++ K++ +++ + ++ + ++EE++ +E
Sbjct: 420 PDRQAVPGRPGPFPSKQQVADEDEIWKQRRRQQSEISAAVERARKRREEEERRMEE---- 475
Query: 252 EGKKEVESKRKNL-AKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKE 310
+ K K K L K G+ S EE ++E EK+R+ + + + + EKE
Sbjct: 476 QRKAACAEKLKRLDEKLGILEKQPSPEEIREREREKEREREKELEKEQEQ-----EREKE 530
Query: 311 -AADRKRKQEEQMETEQQNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNLD 369
DR+R+QE++ E E++ + + + + +K EK++E ++ ++K K L+
Sbjct: 531 REKDRERQQEKEKELEKEQEKQREMEKERKQEKEKELERQKEKEKELQKMKEQEKECELE 590
Query: 370 VNRCIEALDE 379
R E L+E
Sbjct: 591 KER--EKLEE 598
Score = 51.6 bits (122), Expect = 2e-06
Identities = 47/226 (20%), Positives = 108/226 (47%), Gaps = 13/226 (5%)
Query: 118 SKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVS 177
SK+ E++ + + +I+ R R+ + E+++E + ++ K+
Sbjct: 434 SKQQVADEDEIWKQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEKLG 493
Query: 178 PKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEG 237
+P+ E++ R R K ++ E ++ E+++ ++K + EK ++Q +K++E
Sbjct: 494 ILEKQPSPEEIR---EREREKERER----EKELEKEQEQEREK-EREKDRERQQEKEKEL 545
Query: 238 QKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTA 297
+KE++K R+ +++ +KE E +R+ + + + E+E E EK+R+
Sbjct: 546 EKEQEKQREMEKERKQEKEKELERQKEKEKELQKMKEQEKE---CELEKEREKLEEKIEP 602
Query: 298 HRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKK--PEVKKVE 341
N+ ++E+ + K+EE + T Q + K+ P V + E
Sbjct: 603 REPNLEPMVEKQESENSCNKEEEPVFTRQDSNRSEKEATPVVHETE 648
Score = 47.8 bits (112), Expect = 3e-05
Identities = 57/261 (21%), Positives = 114/261 (43%), Gaps = 27/261 (10%)
Query: 95 QQAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDIT--------TPKAAR 146
+Q +QS S+ VE K + + + KA+ + K +D +P+ R
Sbjct: 446 KQRRRQQSEISAAVERARKRREEEERRMEEQRKAACAEKLKRLDEKLGILEKQPSPEEIR 505
Query: 147 ---RGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQP 203
R ++R+ EK++E E+ + R R E ++ K + + + +++
Sbjct: 506 EREREKEREREKELEKEQE-------QEREKEREKDRERQQEKEKELEKEQEKQREMEKE 558
Query: 204 CPSESDIITEEDKSKKKG-QEEKQPKKQPKKDEEGQKEEDK-----PRKEPDKKEGKKEV 257
E + E K K+K Q+ K+ +K+ + ++E +K E+K P EP ++ + E
Sbjct: 559 RKQEKEKELERQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREPNLEPMVEKQESEN 618
Query: 258 ESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRK 317
++ ++ SE+E E + + G + A K Q +K R ++
Sbjct: 619 SCNKEEEPVFTRQDSNRSEKEATPVVHETEPESGSQPRPAVLSGYFK-QFQKSLPPRFQR 677
Query: 318 QEEQMETE--QQNKDEGKKPE 336
Q+EQM+ + QQ + +G P+
Sbjct: 678 QQEQMKQQQWQQQQQQGVLPQ 698
Score = 38.1 bits (87), Expect = 0.020
Identities = 49/211 (23%), Positives = 88/211 (41%), Gaps = 26/211 (12%)
Query: 83 EIDNNPKVKFSSQQAATKQSNASSDVEVEEKETSVSKEDT-DHEEKASNEDVT-KAVDIT 140
+++ +PK F + SS+ +V+ K S S ED H A+N+ +A D
Sbjct: 853 QLEAHPKADFIRE---------SSEAQVQ-KFLSRSVEDVRPHHTDANNQSACFEAPDQK 902
Query: 141 TPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMV 200
T A + R E Q + + + ++ K +R P+A G PK+
Sbjct: 903 TLSAPQEERISAVESQPSRKRS---VSHGSNHTQKPDEQRSEPSA---------GIPKVT 950
Query: 201 KQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEED-KPRKEPDKKEGKKEVES 259
+ S+ I E+K KK+G +P+K + + E PR +++E +
Sbjct: 951 SRCIDSKEPIERPEEKPKKEGFIRSSEGPKPEKVYKSKSETRWGPRPSSNRREEVNDRPV 1010
Query: 260 KRKN-LAKTGVTSTSDSEEEGDDQEGEKKRK 289
+R + K + + E+ ++EGEK K
Sbjct: 1011 RRSGPIKKPVLRDMKEEREQRKEKEGEKAEK 1041
Score = 29.3 bits (64), Expect = 9.3
Identities = 18/89 (20%), Positives = 30/89 (33%)
Query: 442 KSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQPQHNGESNEDSK 501
++ + R + GK+GP TG +NG S P G+ N
Sbjct: 1565 RNFSGPRNERRSGPPSKSGKRGPFDDQPAGTTGVDLINGSSAHHQEGVPNGTGQKNSKDS 1624
Query: 502 DNHEASTKKKPSSEERETEISLKDSTLDN 530
+ K + +E +L L+N
Sbjct: 1625 TGKKREDPKPGPKKPKEKVDALSQFDLNN 1653
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 62.4 bits (150), Expect = 1e-09
Identities = 89/385 (23%), Positives = 163/385 (42%), Gaps = 45/385 (11%)
Query: 154 EKQVETEEAGVVTTATA-SVNLKVSPKRGRPAATEVKIPKPRGRPKMV---KQPCPSESD 209
E +VE E++ + TA + L VS K + A E K +P + V K P + +
Sbjct: 459 ETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAP 518
Query: 210 IITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGV 269
+ EE+ K EE++ +++ ++++EG K D+ + +KEG E E + +T
Sbjct: 519 EVKEEEGEK----EEEEGQEEEEEEDEGAKS-DQAEEGGSEKEGSSEKEEGEQEEGET-- 571
Query: 270 TSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNK 329
++E EG++ E ++++K + + L + E ++ + + E++ K
Sbjct: 572 ----EAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGK 627
Query: 330 ---------DEGKKPEVKK-VEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEA--- 376
++GK P K VE+K + S + + E K + V ++
Sbjct: 628 SPVPKSPVEEKGKSPVPKSPVEEKGK----SPVPKSPVEEKGKSPVSKSPVEEKAKSPVP 683
Query: 377 ---LDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGD 433
++E S + QK E + + KV + EK + K K V E
Sbjct: 684 KSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKK-EEKPKDVPEKKKAESPVKEEA 742
Query: 434 SVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQPQHN 493
+ KS+ + E TK++GK +K EKE+ G + GGS+ ++G+
Sbjct: 743 VAEVVTITKSVKVHLEKE----TKEEGKPLQQEK-EKEKAGGE---GGSE-EEGSDKGAK 793
Query: 494 GESNEDSKDNHEASTKKKPSSEERE 518
G ED N E K++ E +E
Sbjct: 794 GSRKEDIAVNGEVEGKEEVEQETKE 818
Score = 59.3 bits (142), Expect = 8e-09
Identities = 82/345 (23%), Positives = 133/345 (38%), Gaps = 73/345 (21%)
Query: 56 KDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVE---E 112
K+ P +E +E K + K + E + + + ++ + A SD E E
Sbjct: 495 KEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSE 554
Query: 113 KETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASV 172
KE S KE+ + EE T +A + K EK+VE + V T
Sbjct: 555 KEGSSEKEEGEQEEGE-----------TEAEAEGEEAEAKEEKKVEEKSEEVATKEELVA 603
Query: 173 NLKV-------SPKRGRPAATEVKIPKPRGR---------PK------------------ 198
+ KV SP P + K P P+ PK
Sbjct: 604 DAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEE 663
Query: 199 -------------MVKQPCP----SESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEE 241
K P P E+ E K ++K +EEK+ K+ P K+E+ +K+E
Sbjct: 664 KGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAP-KEEKVEKKE 722
Query: 242 DKPRKEPDKKEG----KKEVESKRKNLAKT-GVTSTSDSEEEGD--DQEGEKKRKGGRNF 294
+KP+ P+KK+ K+E ++ + K+ V +++EEG QE EK++ GG
Sbjct: 723 EKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGG 782
Query: 295 QTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKK 339
+ KE + E + E EQ+ K++G E +K
Sbjct: 783 SEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEK 827
Score = 54.7 bits (130), Expect = 2e-07
Identities = 44/165 (26%), Positives = 73/165 (44%), Gaps = 2/165 (1%)
Query: 183 PAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEED 242
P KI KP+ +K +II E +K + E+ ++ KEE
Sbjct: 429 PITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEK 488
Query: 243 KPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNM 302
K E ++E + E E + T+ EEEG+ +E E + + + A
Sbjct: 489 KEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQA 548
Query: 303 LKGQHEKEAADRKRK-QEEQMETEQQNK-DEGKKPEVKKVEKKRE 345
+G EKE + K + ++E+ ETE + + +E + E KKVE+K E
Sbjct: 549 EEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSE 593
Score = 45.4 bits (106), Expect = 1e-04
Identities = 91/427 (21%), Positives = 165/427 (38%), Gaps = 78/427 (18%)
Query: 111 EEKETSVSKE---DTDHEEKASNEDVTKAVDITTPK------------------------ 143
E+KE + KE + + EE A+ + KA T P+
Sbjct: 487 EKKEAAEEKEEEPEAEEEEVAAKKSPVKA---TAPEVKEEEGEKEEEEGQEEEEEEDEGA 543
Query: 144 ---------AARRGRKRKAE---KQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIP 191
+ + G K E ++ ETE A A KV K A E +
Sbjct: 544 KSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVA 603
Query: 192 KPR-GRPKMVKQPCPSESDIITEEDKS--KKKGQEEKQPKKQPKKDEEGQKEEDKPRKEP 248
+ +P+ K P P + E+ KS K EEK PK E + + P K P
Sbjct: 604 DAKVEKPEKAKSPVPKSP--VEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVP-KSP 660
Query: 249 DKKEGKKEV-ESKRKNLAKTGV--TSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKG 305
+++GK V +S + AK+ V + +++ + + +GE+K + + + A + ++
Sbjct: 661 VEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEK 720
Query: 306 QHEKEAADRKRKQEE------------------QMETEQQNKDEGKKPEVKKVEKKRETS 347
+ EK ++K+ E ++ E++ K+EGK + +K ++K
Sbjct: 721 KEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGE 780
Query: 348 MDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITT----LKKI 403
S + K S K +++ VN +E +E+ ++ + + T L
Sbjct: 781 GGSEEEGSDKGAKGSRK-EDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPA 839
Query: 404 RRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKG 463
K EK + K + EG T+ + KS+ ++ EE +T ++ K
Sbjct: 840 DEKKGGDKSEEKVVVTKTVEK---ITSEGGDGATKYITKSVTVTQKVEEHEETFEE-KLV 895
Query: 464 PNKKLEK 470
KK+EK
Sbjct: 896 STKKVEK 902
Score = 29.6 bits (65), Expect = 7.1
Identities = 61/344 (17%), Positives = 129/344 (37%), Gaps = 79/344 (22%)
Query: 260 KRKNLAKTGVTST-----SDSEEEGDD-----QEGEKKRKGGRNFQTAHRRNMLKGQHEK 309
+RK+ KT +++ S E D +E K R + ++ E+
Sbjct: 257 ERKDYLKTDISTALKEIRSQLESHSDQNMHQAEEWFKCRYAKLTEAAEQNKEAIRSAKEE 316
Query: 310 EAADRKRKQEEQMETEQ-QNKDEGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLKIDNL 368
A R++ Q + +E E + E + ++ +E++ + S I +++N L+
Sbjct: 317 IAEYRRQLQSKSIELESVRGTKESLERQLSDIEERHNHDLSSYQDTIQ-QLENELRGTKW 375
Query: 369 DVNRCIEALDELASLQVTMQ--------------------------QAQKHTEMITTLKK 402
++ R + +L ++++ + H IT K
Sbjct: 376 EMARHLREYQDLLNVKMALDIEIAAYRKLLEGEETRFSTFAGSITGPLYTHRPPITISSK 435
Query: 403 IRRFKVS-----------QVIMEKSTMLYNKFKN---MFLVGEGDSVITQVLNKSLAEQR 448
I++ KV + I+E++ + K + + + E +V + K AE++
Sbjct: 436 IQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEK 495
Query: 449 QHE-EANKTKDQGKKGPNKKLE---KEQTGSKTLNGGSDAQD--------------GNQP 490
+ E EA + + KK P K KE+ G K G + ++ G++
Sbjct: 496 EEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSEK 555
Query: 491 QHNGESNEDSK---------DNHEASTKKKPSSEERETEISLKD 525
+ + E E + + EA K++ EE+ E++ K+
Sbjct: 556 EGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKE 599
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 62.4 bits (150), Expect = 1e-09
Identities = 89/385 (23%), Positives = 163/385 (42%), Gaps = 45/385 (11%)
Query: 154 EKQVETEEAGVVTTATA-SVNLKVSPKRGRPAATEVKIPKPRGRPKMV---KQPCPSESD 209
E +VE E++ + TA + L VS K + A E K +P + V K P + +
Sbjct: 83 ETKVEDEKSEMEEALTAITEELAVSMKEEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAP 142
Query: 210 IITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGV 269
+ EE+ K EE++ +++ ++++EG K D+ + +KEG E E + +T
Sbjct: 143 EVKEEEGEK----EEEEGQEEEEEEDEGAKS-DQAEEGGSEKEGSSEKEEGEQEEGET-- 195
Query: 270 TSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNK 329
++E EG++ E ++++K + + L + E ++ + + E++ K
Sbjct: 196 ----EAEAEGEEAEAKEEKKVEEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGK 251
Query: 330 ---------DEGKKPEVKK-VEKKRETSMDSRLQRIHAEIKNSLKIDNLDVNRCIEA--- 376
++GK P K VE+K + S + + E K + V ++
Sbjct: 252 SPVPKSPVEEKGKSPVPKSPVEEKGK----SPVPKSPVEEKGKSPVSKSPVEEKAKSPVP 307
Query: 377 ---LDELASLQVTMQQAQKHTEMITTLKKIRRFKVSQVIMEKSTMLYNKFKNMFLVGEGD 433
++E S + QK E + + KV + EK + K K V E
Sbjct: 308 KSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEKK-EEKPKDVPEKKKAESPVKEEA 366
Query: 434 SVITQVLNKSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQPQHN 493
+ KS+ + E TK++GK +K EKE+ G + GGS+ ++G+
Sbjct: 367 VAEVVTITKSVKVHLEKE----TKEEGKPLQQEK-EKEKAGGE---GGSE-EEGSDKGAK 417
Query: 494 GESNEDSKDNHEASTKKKPSSEERE 518
G ED N E K++ E +E
Sbjct: 418 GSRKEDIAVNGEVEGKEEVEQETKE 442
Score = 59.3 bits (142), Expect = 8e-09
Identities = 82/345 (23%), Positives = 133/345 (38%), Gaps = 73/345 (21%)
Query: 56 KDIFPYSENKEKYGKPNKRKGFNEGLWEIDNNPKVKFSSQQAATKQSNASSDVEVE---E 112
K+ P +E +E K + K + E + + + ++ + A SD E E
Sbjct: 119 KEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQAEEGGSE 178
Query: 113 KETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEKQVETEEAGVVTTATASV 172
KE S KE+ + EE T +A + K EK+VE + V T
Sbjct: 179 KEGSSEKEEGEQEEGE-----------TEAEAEGEEAEAKEEKKVEEKSEEVATKEELVA 227
Query: 173 NLKV-------SPKRGRPAATEVKIPKPRGR---------PK------------------ 198
+ KV SP P + K P P+ PK
Sbjct: 228 DAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEE 287
Query: 199 -------------MVKQPCP----SESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEE 241
K P P E+ E K ++K +EEK+ K+ P K+E+ +K+E
Sbjct: 288 KGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAP-KEEKVEKKE 346
Query: 242 DKPRKEPDKKEG----KKEVESKRKNLAKT-GVTSTSDSEEEGD--DQEGEKKRKGGRNF 294
+KP+ P+KK+ K+E ++ + K+ V +++EEG QE EK++ GG
Sbjct: 347 EKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGEGG 406
Query: 295 QTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKPEVKK 339
+ KE + E + E EQ+ K++G E +K
Sbjct: 407 SEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGREEEK 451
Score = 54.7 bits (130), Expect = 2e-07
Identities = 44/165 (26%), Positives = 73/165 (44%), Gaps = 2/165 (1%)
Query: 183 PAATEVKIPKPRGRPKMVKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEED 242
P KI KP+ +K +II E +K + E+ ++ KEE
Sbjct: 53 PITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEELAVSMKEEK 112
Query: 243 KPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNM 302
K E ++E + E E + T+ EEEG+ +E E + + + A
Sbjct: 113 KEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQA 172
Query: 303 LKGQHEKEAADRKRK-QEEQMETEQQNK-DEGKKPEVKKVEKKRE 345
+G EKE + K + ++E+ ETE + + +E + E KKVE+K E
Sbjct: 173 EEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSE 217
Score = 45.4 bits (106), Expect = 1e-04
Identities = 91/427 (21%), Positives = 165/427 (38%), Gaps = 78/427 (18%)
Query: 111 EEKETSVSKE---DTDHEEKASNEDVTKAVDITTPK------------------------ 143
E+KE + KE + + EE A+ + KA T P+
Sbjct: 111 EKKEAAEEKEEEPEAEEEEVAAKKSPVKA---TAPEVKEEEGEKEEEEGQEEEEEEDEGA 167
Query: 144 ---------AARRGRKRKAE---KQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIP 191
+ + G K E ++ ETE A A KV K A E +
Sbjct: 168 KSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEELVA 227
Query: 192 KPR-GRPKMVKQPCPSESDIITEEDKS--KKKGQEEKQPKKQPKKDEEGQKEEDKPRKEP 248
+ +P+ K P P + E+ KS K EEK PK E + + P K P
Sbjct: 228 DAKVEKPEKAKSPVPKSP--VEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVP-KSP 284
Query: 249 DKKEGKKEV-ESKRKNLAKTGV--TSTSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKG 305
+++GK V +S + AK+ V + +++ + + +GE+K + + + A + ++
Sbjct: 285 VEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVEK 344
Query: 306 QHEKEAADRKRKQEE------------------QMETEQQNKDEGKKPEVKKVEKKRETS 347
+ EK ++K+ E ++ E++ K+EGK + +K ++K
Sbjct: 345 KEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEEGKPLQQEKEKEKAGGE 404
Query: 348 MDSRLQRIHAEIKNSLKIDNLDVNRCIEALDELASLQVTMQQAQKHTEMITT----LKKI 403
S + K S K +++ VN +E +E+ ++ + + T L
Sbjct: 405 GGSEEEGSDKGAKGSRK-EDIAVNGEVEGKEEVEQETKEKGSGREEEKGVVTNGLDLSPA 463
Query: 404 RRFKVSQVIMEKSTMLYNKFKNMFLVGEGDSVITQVLNKSLAEQRQHEEANKTKDQGKKG 463
K EK + K + EG T+ + KS+ ++ EE +T ++ K
Sbjct: 464 DEKKGGDKSEEKVVVTKTVEK---ITSEGGDGATKYITKSVTVTQKVEEHEETFEE-KLV 519
Query: 464 PNKKLEK 470
KK+EK
Sbjct: 520 STKKVEK 526
Score = 29.3 bits (64), Expect = 9.3
Identities = 20/93 (21%), Positives = 45/93 (48%), Gaps = 16/93 (17%)
Query: 442 KSLAEQRQHEEANKTKDQGKKGPNKKLEKEQTGSKTLNGGSDAQDGNQPQHNGESNEDSK 501
K+ A + + EE K +++G++ + E+E G+K+ + G++ + + E E +
Sbjct: 138 KATAPEVKEEEGEKEEEEGQE----EEEEEDEGAKS---DQAEEGGSEKEGSSEKEEGEQ 190
Query: 502 ---------DNHEASTKKKPSSEERETEISLKD 525
+ EA K++ EE+ E++ K+
Sbjct: 191 EEGETEAEAEGEEAEAKEEKKVEEKSEEVATKE 223
>gi|239747174 PREDICTED: hypothetical protein XP_002343931, partial
[Homo sapiens]
Length = 213
Score = 61.6 bits (148), Expect = 2e-09
Identities = 36/154 (23%), Positives = 80/154 (51%), Gaps = 13/154 (8%)
Query: 213 EEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDK--KEGKKEVESKRKNLAKTGVT 270
E D++K+ E++ ++ ++D E +E D+ R+ + +EG+++ E +R
Sbjct: 30 ERDRAKESKTEDRHSERDRQRDRERNRERDRDREREKQTDREGERQRERERDR------- 82
Query: 271 STSDSEEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKD 330
D + E ++E +K+R+ R+ +T R K + + DR+R+++++M E+Q
Sbjct: 83 ---DRQRE-TERERDKERETDRHTETDRERQKQKEREMERVRDREREKQKEMGRERQTDR 138
Query: 331 EGKKPEVKKVEKKRETSMDSRLQRIHAEIKNSLK 364
E + ++ E++RET + + + H E + K
Sbjct: 139 ETDRERERQAERERETGRERKTEDRHRERERERK 172
Score = 51.6 bits (122), Expect = 2e-06
Identities = 44/217 (20%), Positives = 99/217 (45%), Gaps = 18/217 (8%)
Query: 140 TTPKAARRGRKRKAEKQVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKM 199
T + R R+R+ E E + A T +R R E + R R +
Sbjct: 12 TETETMDRQRERRRETDRERDRAKESKTEDRH------SERDRQRDRERNRERDRDRERE 65
Query: 200 VKQPCPSESDIITEEDKSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVES 259
+ E E D+ + Q E + ++ +++ + E D+ R++ ++E ++ +
Sbjct: 66 KQTDREGERQRERERDRDR---QRETERERDKERETDRHTETDRERQKQKEREMERVRDR 122
Query: 260 KRKNLAKTGVTSTSDSEEEGD-DQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQ 318
+R+ + G +D E + + +++ E++R+ GR +T R H + +RKR++
Sbjct: 123 EREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDR-------HRERERERKRER 175
Query: 319 EEQMET-EQQNKDEGKKPEVKKVEKKRETSMDSRLQR 354
E + ET E++ + ++ ++ ++KR+ +S +R
Sbjct: 176 ERKRETKERERHTDMERERQRETDRKRDRQRESERER 212
Score = 50.1 bits (118), Expect = 5e-06
Identities = 51/250 (20%), Positives = 109/250 (43%), Gaps = 38/250 (15%)
Query: 96 QAATKQSNASSDVEVEEKETSVSKEDTDHEEKASNEDVTKAVDITTPKAARRGRKRKAEK 155
++ T+ + ++ E +++ +E TD E + E T+ + R R R+ ++
Sbjct: 2 ESKTEGRHTHTETETMDRQRERRRE-TDRERDRAKESKTEDRHSERDRQRDRERNRERDR 60
Query: 156 QVETEEAGVVTTATASVNLKVSPKRGRPAATEVKIPKPRGRPKMVKQPCPSESDIITEED 215
E E+ T + R R TE + K R E+D TE D
Sbjct: 61 DREREKQ---TDREGERQRERERDRDRQRETERERDKER------------ETDRHTETD 105
Query: 216 KSKKKGQEEKQPKKQPKKDEEGQKEEDKPRKEPDKKEGKKEVESKRKNLAKTGVTSTSDS 275
+ ++K +K+ + + +D E +K+++ R+ +E +E E + + +TG +
Sbjct: 106 RERQK---QKEREMERVRDREREKQKEMGRERQTDRETDRERERQAERERETG----RER 158
Query: 276 EEEGDDQEGEKKRKGGRNFQTAHRRNMLKGQHEKEAADRKRKQEEQMETEQQNKDEGKKP 335
+ E +E E++RK R E++ ++R++ ME E+Q + + K+
Sbjct: 159 KTEDRHRERERERKRER---------------ERKRETKERERHTDMERERQRETDRKRD 203
Query: 336 EVKKVEKKRE 345
++ E++R+
Sbjct: 204 RQRESERERD 213
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.303 0.123 0.331
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,124,262
Number of Sequences: 37866
Number of extensions: 1128064
Number of successful extensions: 25558
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 682
Number of HSP's successfully gapped in prelim test: 1096
Number of HSP's that attempted gapping in prelim test: 7404
Number of HSP's gapped (non-prelim): 8469
length of query: 530
length of database: 18,247,518
effective HSP length: 107
effective length of query: 423
effective length of database: 14,195,856
effective search space: 6004847088
effective search space used: 6004847088
T: 11
A: 40
X1: 17 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.