BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|189571664 DEP domain containing 6 [Homo sapiens] (409 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|189571664 DEP domain containing 6 [Homo sapiens] 823 0.0 gi|47578117 DEP domain containing 2 isoform b [Homo sapiens] 145 6e-35 gi|47578115 DEP domain containing 2 isoform a [Homo sapiens] 145 6e-35 gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent R... 141 9e-34 gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isof... 67 3e-11 gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isof... 67 3e-11 gi|74271832 G protein-coupled receptor 155 isoform 9 [Homo sapiens] 57 2e-08 gi|74271834 G protein-coupled receptor 155 isoform 10 [Homo sapi... 57 2e-08 gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sap... 55 1e-07 gi|121583483 phosphatidylinositol-3-phosphate 5-kinase type III ... 50 4e-06 gi|22749359 phosphatidylinositol-3-phosphate 5-kinase type III i... 50 4e-06 gi|122937241 SH3 and multiple ankyrin repeat domains 3 [Homo sap... 47 3e-05 gi|19743796 SH3 and multiple ankyrin repeat domains 2 isoform 2 ... 45 9e-05 gi|226817313 SH3 and multiple ankyrin repeat domains 2 isoform 1... 45 9e-05 gi|7706643 pleckstrin 2 [Homo sapiens] 45 1e-04 gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isof... 44 2e-04 gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isofo... 44 2e-04 gi|209862859 DEP domain containing 5 isoform 3 [Homo sapiens] 43 5e-04 gi|7662222 DEP domain containing 5 isoform 1 [Homo sapiens] 43 5e-04 gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b ... 43 6e-04 gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [... 43 6e-04 gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a ... 43 6e-04 gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo... 42 0.001 gi|119120915 rhophilin 1 [Homo sapiens] 42 0.001 gi|22748695 DEP domain containing 4 [Homo sapiens] 40 0.004 gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2) int... 39 0.007 gi|223633999 DEP domain containing 1B isoform 1 [Homo sapiens] 39 0.009 gi|223633997 DEP domain containing 1B isoform 2 [Homo sapiens] 39 0.009 gi|4506509 regulator of G-protein signalling 12 isoform 2 [Homo ... 39 0.009 gi|38327601 regulator of G-protein signalling 12 isoform 1 [Homo... 39 0.009 >gi|189571664 DEP domain containing 6 [Homo sapiens] Length = 409 Score = 823 bits (2127), Expect = 0.0 Identities = 409/409 (100%), Positives = 409/409 (100%) Query: 1 MEEGGSTGSAGSDSSTSGSGGAQQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTY 60 MEEGGSTGSAGSDSSTSGSGGAQQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTY Sbjct: 1 MEEGGSTGSAGSDSSTSGSGGAQQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTY 60 Query: 61 PNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKD 120 PNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKD Sbjct: 61 PNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKD 120 Query: 121 DGTFPLDNEVKAFMRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEA 180 DGTFPLDNEVKAFMRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEA Sbjct: 121 DGTFPLDNEVKAFMRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEA 180 Query: 181 TTRKEAEQLCHRLMEHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLNEKSPSSQE 240 TTRKEAEQLCHRLMEHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLNEKSPSSQE Sbjct: 181 TTRKEAEQLCHRLMEHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLNEKSPSSQE 240 Query: 241 THDSPFCLRKQSHDNRKSTSFMSVSPSKEIKIVSAVRRSSMSSCGSSGYFSSSPTLSSSP 300 THDSPFCLRKQSHDNRKSTSFMSVSPSKEIKIVSAVRRSSMSSCGSSGYFSSSPTLSSSP Sbjct: 241 THDSPFCLRKQSHDNRKSTSFMSVSPSKEIKIVSAVRRSSMSSCGSSGYFSSSPTLSSSP 300 Query: 301 PVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGP 360 PVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGP Sbjct: 301 PVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGP 360 Query: 361 AAAAGMKVCQFVVSVNGLNVLHVDYRTVSNLILTGPRTIVMEVMEELEC 409 AAAAGMKVCQFVVSVNGLNVLHVDYRTVSNLILTGPRTIVMEVMEELEC Sbjct: 361 AAAAGMKVCQFVVSVNGLNVLHVDYRTVSNLILTGPRTIVMEVMEELEC 409 >gi|47578117 DEP domain containing 2 isoform b [Homo sapiens] Length = 979 Score = 145 bits (366), Expect = 6e-35 Identities = 110/352 (31%), Positives = 172/352 (48%), Gaps = 14/352 (3%) Query: 37 GEQL-RLRLHEEKVIKDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADR 95 GE+L ++ + +IKDR+ L T+P CF+ E + WL+E E E + L Q L + Sbjct: 382 GEKLYKMMCRQGNLIKDRKRKLTTFPKCFLGSEFVSWLLEIGEIHRPEEGVHLGQALLEN 441 Query: 96 GIIHHVCDEHKEFKDVKLFYRFRKDDGTFPLDNEVK-AFMRGQRLYEKLMSPENTLLQPR 154 GIIHHV D+H +FK ++ YRFR DDGTF NE++ +G RLY +L S +++ + Sbjct: 442 GIIHHVTDKH-QFKPEQMLYRFRYDDGTFYPRNEMQDVISKGVRLYCRLHSLFTPVIRDK 500 Query: 155 EEEGVKYERTFMASEFLDWLVQEGEATTRKEAEQLCHRLMEHGIIQHVSNKHPFVDSNLL 214 + Y+ MA++ +DWL+ +G+ TR+EA L ++G + HV K F D LL Sbjct: 501 DYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFGVGLCDNGFMHHVLEKSEFKDEPLL 560 Query: 215 YQFRMNFRRRRRLMELLNEKSPSSQETHDSPFCLRKQSHDNRKSTSFMSVSPSKEIKIVS 274 ++F + M+ K + L +S++ + IK+V Sbjct: 561 FRFFSDEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNEGSYGFGLEDKNKVPIIKLVE 620 Query: 275 AVRRSSMS--SCGSSGYFSSSPTLSSSP--PVLCNPKSVL--KRPVTSEELLTPGAPYAR 328 + M+ G + + + P V C KS L ++P+ +L P R Sbjct: 621 KGSNAEMAGMEVGKKIFAINGDLVFMRPFNEVDCFLKSCLNSRKPL---RVLVSTKP--R 675 Query: 329 KTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKVCQFVVSVNGLNV 380 +T I A G GF +RG P + AV AAAAG+ Q ++ VNG+NV Sbjct: 676 ETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCIIKVNGINV 727 Score = 69.7 bits (169), Expect = 5e-12 Identities = 39/94 (41%), Positives = 54/94 (57%), Gaps = 3/94 (3%) Query: 30 MAEVLVTGEQLRLRLHE--EKVIKDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIK 87 M +V+ G +L RLH VI+D+ +HL+TY + +A +LIDWLI + RE A+ Sbjct: 475 MQDVISKGVRLYCRLHSLFTPVIRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMI 534 Query: 88 LMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKDD 121 L D G +HHV E EFKD L +RF D+ Sbjct: 535 FGVGLCDNGFMHHVL-EKSEFKDEPLLFRFFSDE 567 Score = 67.4 bits (163), Expect = 2e-11 Identities = 35/110 (31%), Positives = 64/110 (58%), Gaps = 4/110 (3%) Query: 127 DNEVKAFMRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEATTRKEA 186 D V +G++LY K+M + L++ R+ + + + F+ SEF+ WL++ GE +E Sbjct: 373 DTWVMISEQGEKLY-KMMCRQGNLIKDRKRKLTTFPKCFLGSEFVSWLLEIGEIHRPEEG 431 Query: 187 EQLCHRLMEHGIIQHVSNKHPFVDSNLLYQFRMN---FRRRRRLMELLNE 233 L L+E+GII HV++KH F +LY+FR + F R + +++++ Sbjct: 432 VHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRNEMQDVISK 481 >gi|47578115 DEP domain containing 2 isoform a [Homo sapiens] Length = 1606 Score = 145 bits (366), Expect = 6e-35 Identities = 110/352 (31%), Positives = 172/352 (48%), Gaps = 14/352 (3%) Query: 37 GEQL-RLRLHEEKVIKDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADR 95 GE+L ++ + +IKDR+ L T+P CF+ E + WL+E E E + L Q L + Sbjct: 382 GEKLYKMMCRQGNLIKDRKRKLTTFPKCFLGSEFVSWLLEIGEIHRPEEGVHLGQALLEN 441 Query: 96 GIIHHVCDEHKEFKDVKLFYRFRKDDGTFPLDNEVK-AFMRGQRLYEKLMSPENTLLQPR 154 GIIHHV D+H +FK ++ YRFR DDGTF NE++ +G RLY +L S +++ + Sbjct: 442 GIIHHVTDKH-QFKPEQMLYRFRYDDGTFYPRNEMQDVISKGVRLYCRLHSLFTPVIRDK 500 Query: 155 EEEGVKYERTFMASEFLDWLVQEGEATTRKEAEQLCHRLMEHGIIQHVSNKHPFVDSNLL 214 + Y+ MA++ +DWL+ +G+ TR+EA L ++G + HV K F D LL Sbjct: 501 DYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMIFGVGLCDNGFMHHVLEKSEFKDEPLL 560 Query: 215 YQFRMNFRRRRRLMELLNEKSPSSQETHDSPFCLRKQSHDNRKSTSFMSVSPSKEIKIVS 274 ++F + M+ K + L +S++ + IK+V Sbjct: 561 FRFFSDEEMEGSNMKHRLMKHDLKVVENVIAKSLLIKSNEGSYGFGLEDKNKVPIIKLVE 620 Query: 275 AVRRSSMS--SCGSSGYFSSSPTLSSSP--PVLCNPKSVL--KRPVTSEELLTPGAPYAR 328 + M+ G + + + P V C KS L ++P+ +L P R Sbjct: 621 KGSNAEMAGMEVGKKIFAINGDLVFMRPFNEVDCFLKSCLNSRKPL---RVLVSTKP--R 675 Query: 329 KTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKVCQFVVSVNGLNV 380 +T I A G GF +RG P + AV AAAAG+ Q ++ VNG+NV Sbjct: 676 ETVKIPDSADGLGFQIRGFGPSVVHAVGRGTVAAAAGLHPGQCIIKVNGINV 727 Score = 69.7 bits (169), Expect = 5e-12 Identities = 39/94 (41%), Positives = 54/94 (57%), Gaps = 3/94 (3%) Query: 30 MAEVLVTGEQLRLRLHE--EKVIKDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIK 87 M +V+ G +L RLH VI+D+ +HL+TY + +A +LIDWLI + RE A+ Sbjct: 475 MQDVISKGVRLYCRLHSLFTPVIRDKDYHLRTYKSVVMANKLIDWLIAQGDCRTREEAMI 534 Query: 88 LMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKDD 121 L D G +HHV E EFKD L +RF D+ Sbjct: 535 FGVGLCDNGFMHHVL-EKSEFKDEPLLFRFFSDE 567 Score = 67.4 bits (163), Expect = 2e-11 Identities = 35/110 (31%), Positives = 64/110 (58%), Gaps = 4/110 (3%) Query: 127 DNEVKAFMRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEATTRKEA 186 D V +G++LY K+M + L++ R+ + + + F+ SEF+ WL++ GE +E Sbjct: 373 DTWVMISEQGEKLY-KMMCRQGNLIKDRKRKLTTFPKCFLGSEFVSWLLEIGEIHRPEEG 431 Query: 187 EQLCHRLMEHGIIQHVSNKHPFVDSNLLYQFRMN---FRRRRRLMELLNE 233 L L+E+GII HV++KH F +LY+FR + F R + +++++ Sbjct: 432 VHLGQALLENGIIHHVTDKHQFKPEQMLYRFRYDDGTFYPRNEMQDVISK 481 >gi|34452732 phosphatidylinositol-3,4,5-trisphosphate-dependent Rac exchange factor 1 [Homo sapiens] Length = 1659 Score = 141 bits (356), Expect = 9e-34 Identities = 114/380 (30%), Positives = 183/380 (48%), Gaps = 30/380 (7%) Query: 23 QQRE-----LERMAEVLVT--GEQLRLRLHEEKV--IKDRRHHLKTYPNCFVAKELIDWL 73 +QRE +ER A V++ GE+L + +KV IKDRR L T P CF+ E + WL Sbjct: 392 EQRESLKLGMERDAYVMIAEKGEKLYHMMMNKKVNLIKDRRRKLSTVPKCFLGNEFVAWL 451 Query: 74 IEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKDDGTFPLDNEVKAF 133 +E E S E + L Q L + GIIHHV D+H +FK+ ++ YRFR DDGT+ +E++ Sbjct: 452 LEIGEISKTEEGVNLGQALLENGIIHHVSDKH-QFKNEQVMYRFRYDDGTYKARSELEDI 510 Query: 134 M-RGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEATTRKEAEQLCHR 192 M +G RLY +L S +++ R+ Y+ S+ +DWL+ +G+ TR+EA L Sbjct: 511 MSKGVRLYCRLHSLYTPVIKDRDYHLKTYKSVLPGSKLVDWLLAQGDCQTREEAVALGVG 570 Query: 193 LMEHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLNEKSPSSQETHDSPF---CLR 249 L +G + HV K F D + ++F + E+ S + Q +D L Sbjct: 571 LCNNGFMHHVLEKSEFRDESQYFRFHAD-------EEMEGTSSKNKQLRNDFKLVENILA 623 Query: 250 KQSHDNRKSTSF-MSVSPSKEIKIVSAVRRSSMS-----SCGSSGYFSSSPTLSSSPPVL 303 K+ + + + + +V +V+R S++ G Y + + P Sbjct: 624 KRLLILPQEEDYGFDIEEKNKAVVVKSVQRGSLAEVAGLQVGRKIYSINEDLVFLRP--F 681 Query: 304 CNPKSVLKRPVTSEE-LLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGPAA 362 +S+L + S L A A++ I F +RG+ P ++ AV A Sbjct: 682 SEVESILNQSFCSRRPLRLLVATKAKEIIKIPDQPDTLCFQIRGAAPPYVYAVGRGSEAM 741 Query: 363 AAGMKVCQFVVSVNGLNVLH 382 AAG+ Q ++ VNG NV++ Sbjct: 742 AAGLCAGQCILKVNGSNVMN 761 >gi|155030206 Rap guanine nucleotide exchange factor (GEF) 4 isoform b [Homo sapiens] Length = 867 Score = 67.0 bits (162), Expect = 3e-11 Identities = 35/87 (40%), Positives = 51/87 (58%), Gaps = 5/87 (5%) Query: 49 VIKDRRHHLKTYPNCFVAKELIDWLIEHKE-ASDRETAIKLMQKLADRGIIHHVCDEHKE 107 +I+DR++HLKTY C V EL+DW+++ R A+ + Q L + G+++HV EH Sbjct: 77 MIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEH-H 135 Query: 108 FKDVKLFYRFRKD---DGTFPLDNEVK 131 F+D LFYRF D D P + E K Sbjct: 136 FQDKYLFYRFLDDEHEDAPLPTEEEKK 162 Score = 46.6 bits (109), Expect = 4e-05 Identities = 29/125 (23%), Positives = 57/125 (45%), Gaps = 2/125 (1%) Query: 131 KAFMRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEAT-TRKEAEQL 189 K G+ L ++S +++ R+ Y + + +E +DW++Q+ +R +A + Sbjct: 58 KILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGM 117 Query: 190 CHRLMEHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLNEKSPSSQETHDSPFCLR 249 L+E G++ HV +H F D L Y+F ++ + EK +E D+ L Sbjct: 118 WQVLLEDGVLNHVDQEHHFQDKYLFYRF-LDDEHEDAPLPTEEEKKECDEELQDTMLLLS 176 Query: 250 KQSHD 254 + D Sbjct: 177 QMGPD 181 >gi|155030204 Rap guanine nucleotide exchange factor (GEF) 4 isoform a [Homo sapiens] Length = 1011 Score = 67.0 bits (162), Expect = 3e-11 Identities = 35/87 (40%), Positives = 51/87 (58%), Gaps = 5/87 (5%) Query: 49 VIKDRRHHLKTYPNCFVAKELIDWLIEHKE-ASDRETAIKLMQKLADRGIIHHVCDEHKE 107 +I+DR++HLKTY C V EL+DW+++ R A+ + Q L + G+++HV EH Sbjct: 221 MIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGMWQVLLEDGVLNHVDQEH-H 279 Query: 108 FKDVKLFYRFRKD---DGTFPLDNEVK 131 F+D LFYRF D D P + E K Sbjct: 280 FQDKYLFYRFLDDEHEDAPLPTEEEKK 306 Score = 46.6 bits (109), Expect = 4e-05 Identities = 29/125 (23%), Positives = 57/125 (45%), Gaps = 2/125 (1%) Query: 131 KAFMRGQRLYEKLMSPENTLLQPREEEGVKYERTFMASEFLDWLVQEGEAT-TRKEAEQL 189 K G+ L ++S +++ R+ Y + + +E +DW++Q+ +R +A + Sbjct: 202 KILRAGKILRNAILSRAPHMIRDRKYHLKTYRQCCVGTELVDWMMQQTPCVHSRTQAVGM 261 Query: 190 CHRLMEHGIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLNEKSPSSQETHDSPFCLR 249 L+E G++ HV +H F D L Y+F ++ + EK +E D+ L Sbjct: 262 WQVLLEDGVLNHVDQEHHFQDKYLFYRF-LDDEHEDAPLPTEEEKKECDEELQDTMLLLS 320 Query: 250 KQSHD 254 + D Sbjct: 321 QMGPD 325 >gi|74271832 G protein-coupled receptor 155 isoform 9 [Homo sapiens] Length = 870 Score = 57.4 bits (137), Expect = 2e-08 Identities = 35/100 (35%), Positives = 54/100 (54%), Gaps = 6/100 (6%) Query: 22 AQQRELERMAEVLVTGEQLRLRLHEE----KVIKDRRHHLKTYPNCFVAKELIDWLIEHK 77 A+ R+ E+ +T +Q + H + ++K+RR KT F +L+ WLIE Sbjct: 736 AENRDSPVSEEIKMTCQQF-IHYHRDLCIRNIVKERRCGAKTSAGTFCGCDLVSWLIEVG 794 Query: 78 EASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRF 117 ASDR A+ +L G+I H+ +E+ EF+D LFYRF Sbjct: 795 LASDRGEAVIYGDRLVQGGVIQHITNEY-EFRDEYLFYRF 833 Score = 47.8 bits (112), Expect = 2e-05 Identities = 21/54 (38%), Positives = 34/54 (62%) Query: 164 TFMASEFLDWLVQEGEATTRKEAEQLCHRLMEHGIIQHVSNKHPFVDSNLLYQF 217 TF + + WL++ G A+ R EA RL++ G+IQH++N++ F D L Y+F Sbjct: 780 TFCGCDLVSWLIEVGLASDRGEAVIYGDRLVQGGVIQHITNEYEFRDEYLFYRF 833 >gi|74271834 G protein-coupled receptor 155 isoform 10 [Homo sapiens] Length = 870 Score = 57.4 bits (137), Expect = 2e-08 Identities = 35/100 (35%), Positives = 54/100 (54%), Gaps = 6/100 (6%) Query: 22 AQQRELERMAEVLVTGEQLRLRLHEE----KVIKDRRHHLKTYPNCFVAKELIDWLIEHK 77 A+ R+ E+ +T +Q + H + ++K+RR KT F +L+ WLIE Sbjct: 736 AENRDSPVSEEIKMTCQQF-IHYHRDLCIRNIVKERRCGAKTSAGTFCGCDLVSWLIEVG 794 Query: 78 EASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRF 117 ASDR A+ +L G+I H+ +E+ EF+D LFYRF Sbjct: 795 LASDRGEAVIYGDRLVQGGVIQHITNEY-EFRDEYLFYRF 833 Score = 47.8 bits (112), Expect = 2e-05 Identities = 21/54 (38%), Positives = 34/54 (62%) Query: 164 TFMASEFLDWLVQEGEATTRKEAEQLCHRLMEHGIIQHVSNKHPFVDSNLLYQF 217 TF + + WL++ G A+ R EA RL++ G+IQH++N++ F D L Y+F Sbjct: 780 TFCGCDLVSWLIEVGLASDRGEAVIYGDRLVQGGVIQHITNEYEFRDEYLFYRF 833 >gi|120587025 SH3 and multiple ankyrin repeat domains 1 [Homo sapiens] Length = 2161 Score = 54.7 bits (130), Expect = 1e-07 Identities = 33/102 (32%), Positives = 57/102 (55%), Gaps = 19/102 (18%) Query: 322 PGAPYARKTFTIV---GDAVGWGFVVRGSKPC----------------HIQAVDPSGPAA 362 PG+ Y K T++ D+ G+GFV+RG+K ++++VD G A Sbjct: 653 PGSDYIIKEKTVLLQKKDSEGFGFVLRGAKAQTPIEEFTPTPAFPALQYLESVDEGGVAW 712 Query: 363 AAGMKVCQFVVSVNGLNVLHVDYRTVSNLILTGPRTIVMEVM 404 AG+++ F++ VNG NV+ V +R V N+I G T++++V+ Sbjct: 713 RAGLRMGDFLIEVNGQNVVKVGHRQVVNMIRQGGNTLMVKVV 754 >gi|121583483 phosphatidylinositol-3-phosphate 5-kinase type III isoform 2 [Homo sapiens] Length = 2098 Score = 50.1 bits (118), Expect = 4e-06 Identities = 24/66 (36%), Positives = 37/66 (56%) Query: 51 KDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKD 110 +D R+ L+T+PNC V KEL++WLI + + R AI + Q + D + V + F+D Sbjct: 372 QDHRYWLRTHPNCIVGKELVNWLIRNGHIATRAQAIAIGQAMVDGRWLDCVSHHDQLFRD 431 Query: 111 VKLFYR 116 YR Sbjct: 432 EYALYR 437 >gi|22749359 phosphatidylinositol-3-phosphate 5-kinase type III isoform 3 [Homo sapiens] Length = 451 Score = 50.1 bits (118), Expect = 4e-06 Identities = 24/66 (36%), Positives = 37/66 (56%) Query: 51 KDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKD 110 +D R+ L+T+PNC V KEL++WLI + + R AI + Q + D + V + F+D Sbjct: 275 QDHRYWLRTHPNCIVGKELVNWLIRNGHIATRAQAIAIGQAMVDGRWLDCVSHHDQLFRD 334 Query: 111 VKLFYR 116 YR Sbjct: 335 EYALYR 340 >gi|122937241 SH3 and multiple ankyrin repeat domains 3 [Homo sapiens] Length = 1747 Score = 47.0 bits (110), Expect = 3e-05 Identities = 28/85 (32%), Positives = 46/85 (54%), Gaps = 16/85 (18%) Query: 336 DAVGWGFVVRGSKP----------------CHIQAVDPSGPAAAAGMKVCQFVVSVNGLN 379 D G+GFV+RG+K ++++VD G A AG++ F++ VNG+N Sbjct: 594 DHEGFGFVLRGAKAETPIEEFTPTPAFPALQYLESVDVEGVAWRAGLRTGDFLIEVNGVN 653 Query: 380 VLHVDYRTVSNLILTGPRTIVMEVM 404 V+ V ++ V LI G +VM+V+ Sbjct: 654 VVKVGHKQVVALIRQGGNRLVMKVV 678 >gi|19743796 SH3 and multiple ankyrin repeat domains 2 isoform 2 [Homo sapiens] Length = 281 Score = 45.4 bits (106), Expect = 9e-05 Identities = 27/85 (31%), Positives = 45/85 (52%), Gaps = 16/85 (18%) Query: 336 DAVGWGFVVRGSKPC----------------HIQAVDPSGPAAAAGMKVCQFVVSVNGLN 379 D G+GFV+RG+K ++++VD G A AG++ F++ VN N Sbjct: 45 DNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNNEN 104 Query: 380 VLHVDYRTVSNLILTGPRTIVMEVM 404 V+ V +R V N+I G +V++V+ Sbjct: 105 VVKVGHRQVVNMIRQGGNHLVLKVV 129 >gi|226817313 SH3 and multiple ankyrin repeat domains 2 isoform 1 [Homo sapiens] Length = 1849 Score = 45.4 bits (106), Expect = 9e-05 Identities = 27/85 (31%), Positives = 45/85 (52%), Gaps = 16/85 (18%) Query: 336 DAVGWGFVVRGSKPC----------------HIQAVDPSGPAAAAGMKVCQFVVSVNGLN 379 D G+GFV+RG+K ++++VD G A AG++ F++ VN N Sbjct: 633 DNEGFGFVLRGAKADTPIEEFTPTPAFPALQYLESVDEGGVAWQAGLRTGDFLIEVNNEN 692 Query: 380 VLHVDYRTVSNLILTGPRTIVMEVM 404 V+ V +R V N+I G +V++V+ Sbjct: 693 VVKVGHRQVVNMIRQGGNHLVLKVV 717 >gi|7706643 pleckstrin 2 [Homo sapiens] Length = 353 Score = 45.1 bits (105), Expect = 1e-04 Identities = 42/157 (26%), Positives = 67/157 (42%), Gaps = 26/157 (16%) Query: 138 RLYEKLMSPENTLLQ--PREEEGVKYERTFMASEFLDWLVQEGEATTRKEAEQLCHRLME 195 R+ +K M NT ++ P E+G Y++TF+ S +DWL+ +R EA L LME Sbjct: 131 RIVDK-MHDSNTGIRSSPNMEQGSTYKKTFLGSSLVDWLISNSFTASRLEAVTLASMLME 189 Query: 196 HGIIQHVSNK-----------HPFV-DSNLLYQFRMNFRRRRRLMELLNEKSPSSQETHD 243 ++ V + F+ DS LY F +++++ E ++ + T Sbjct: 190 ENFLRPVGVRSMGAIRSGDLAEQFLDDSTALYTFAESYKKKISPKEEISLSTVELSGTVV 249 Query: 244 SPFCLRKQSHDN----------RKSTSFMS-VSPSKE 269 L KQ H RK +F+ PSKE Sbjct: 250 KQGYLAKQGHKRKNWKVRRFVLRKDPAFLHYYDPSKE 286 Score = 31.2 bits (69), Expect = 1.8 Identities = 26/112 (23%), Positives = 43/112 (38%), Gaps = 9/112 (8%) Query: 59 TYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFR 118 TY F+ L+DWLI + + R A+ L L + + V V+ R Sbjct: 154 TYKKTFLGSSLVDWLISNSFTASRLEAVTLASMLMEENFLRPV--------GVRSMGAIR 205 Query: 119 KDDGTFPLDNEVKAFMRGQRLYEKLMSP-ENTLLQPREEEGVKYERTFMASE 169 D ++ A Y+K +SP E L E G ++ ++A + Sbjct: 206 SGDLAEQFLDDSTALYTFAESYKKKISPKEEISLSTVELSGTVVKQGYLAKQ 257 >gi|38026934 Rho guanine nucleotide exchange factor (GEF) 11 isoform 2 [Homo sapiens] Length = 1562 Score = 44.3 bits (103), Expect = 2e-04 Identities = 34/119 (28%), Positives = 51/119 (42%), Gaps = 17/119 (14%) Query: 277 RRSSMSSCGSSGYFSSSPTLSSSPPVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGD 336 R SS+SS G S SP+ P +++R V ++ D Sbjct: 11 RLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVIIQK-----------------D 53 Query: 337 AVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKVCQFVVSVNGLNVLHVDYRTVSNLILTG 395 G+GF V G + +Q+V P G A AG+K ++ VNG V + + V LI +G Sbjct: 54 QHGFGFTVSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSG 112 >gi|7662086 Rho guanine nucleotide exchange factor (GEF) 11 isoform 1 [Homo sapiens] Length = 1522 Score = 44.3 bits (103), Expect = 2e-04 Identities = 34/119 (28%), Positives = 51/119 (42%), Gaps = 17/119 (14%) Query: 277 RRSSMSSCGSSGYFSSSPTLSSSPPVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGD 336 R SS+SS G S SP+ P +++R V ++ D Sbjct: 11 RLSSLSSLGDSAPERKSPSHHRQPSDASETTGLVQRCVIIQK-----------------D 53 Query: 337 AVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKVCQFVVSVNGLNVLHVDYRTVSNLILTG 395 G+GF V G + +Q+V P G A AG+K ++ VNG V + + V LI +G Sbjct: 54 QHGFGFTVSGDRIVLVQSVRPGGAAMKAGVKEGDRIIKVNGTMVTNSSHLEVVKLIKSG 112 >gi|209862859 DEP domain containing 5 isoform 3 [Homo sapiens] Length = 1594 Score = 43.1 bits (100), Expect = 5e-04 Identities = 25/98 (25%), Positives = 40/98 (40%), Gaps = 1/98 (1%) Query: 8 GSAGSDSSTSGSGGAQQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTYPNCFVAK 67 G G S+ S +QQ + E L H ++ P CF++ Sbjct: 1140 GEQGYSSTNSSDSSSQQLVASSLTSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISA 1199 Query: 68 ELIDWLIEHKEASDRET-AIKLMQKLADRGIIHHVCDE 104 E++ WL+ H E + AI +MQK+ + +I H E Sbjct: 1200 EVVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITHASGE 1237 >gi|7662222 DEP domain containing 5 isoform 1 [Homo sapiens] Length = 1572 Score = 43.1 bits (100), Expect = 5e-04 Identities = 25/98 (25%), Positives = 40/98 (40%), Gaps = 1/98 (1%) Query: 8 GSAGSDSSTSGSGGAQQRELERMAEVLVTGEQLRLRLHEEKVIKDRRHHLKTYPNCFVAK 67 G G S+ S +QQ + E L H ++ P CF++ Sbjct: 1118 GEQGYSSTNSSDSSSQQLVASSLTSSSTLTEILEAMKHPSTGVQLLSEQKGLSPYCFISA 1177 Query: 68 ELIDWLIEHKEASDRET-AIKLMQKLADRGIIHHVCDE 104 E++ WL+ H E + AI +MQK+ + +I H E Sbjct: 1178 EVVHWLVNHVEGIQTQAMAIDIMQKMLEEQLITHASGE 1215 >gi|148747862 Rap guanine nucleotide exchange factor 3 isoform b [Homo sapiens] Length = 881 Score = 42.7 bits (99), Expect = 6e-04 Identities = 37/131 (28%), Positives = 56/131 (42%), Gaps = 10/131 (7%) Query: 7 TGSAGSDSSTSGSGGAQQRELERMAEVLVTGEQLRLRLHEE--KVIKDRRHHLKTYPNCF 64 T S+ S S +Q ER VL G QL L +I+DR++HL+ Y C Sbjct: 32 TPLTNSEESLDFSESLEQASTER---VLRAGRQLHRHLLATCPNLIRDRKYHLRLYRQCC 88 Query: 65 VAKELIDWLIE-HKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKDD-- 121 +EL+D ++ R + + Q L D G + HV + FYRF + Sbjct: 89 SGRELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPE 148 Query: 122 --GTFPLDNEV 130 GT ++ E+ Sbjct: 149 PVGTHEMEEEL 159 >gi|20070215 Rap guanine nucleotide exchange factor 3 isoform b [Homo sapiens] Length = 881 Score = 42.7 bits (99), Expect = 6e-04 Identities = 37/131 (28%), Positives = 56/131 (42%), Gaps = 10/131 (7%) Query: 7 TGSAGSDSSTSGSGGAQQRELERMAEVLVTGEQLRLRLHEE--KVIKDRRHHLKTYPNCF 64 T S+ S S +Q ER VL G QL L +I+DR++HL+ Y C Sbjct: 32 TPLTNSEESLDFSESLEQASTER---VLRAGRQLHRHLLATCPNLIRDRKYHLRLYRQCC 88 Query: 65 VAKELIDWLIE-HKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKDD-- 121 +EL+D ++ R + + Q L D G + HV + FYRF + Sbjct: 89 SGRELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPE 148 Query: 122 --GTFPLDNEV 130 GT ++ E+ Sbjct: 149 PVGTHEMEEEL 159 >gi|148747859 Rap guanine nucleotide exchange factor 3 isoform a [Homo sapiens] Length = 923 Score = 42.7 bits (99), Expect = 6e-04 Identities = 37/131 (28%), Positives = 56/131 (42%), Gaps = 10/131 (7%) Query: 7 TGSAGSDSSTSGSGGAQQRELERMAEVLVTGEQLRLRLHEE--KVIKDRRHHLKTYPNCF 64 T S+ S S +Q ER VL G QL L +I+DR++HL+ Y C Sbjct: 74 TPLTNSEESLDFSESLEQASTER---VLRAGRQLHRHLLATCPNLIRDRKYHLRLYRQCC 130 Query: 65 VAKELIDWLIE-HKEASDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFRKDD-- 121 +EL+D ++ R + + Q L D G + HV + FYRF + Sbjct: 131 SGRELVDGILALGLGVHSRSQVVGICQVLLDEGALCHVKHDWAFQDRDAQFYRFPGPEPE 190 Query: 122 --GTFPLDNEV 130 GT ++ E+ Sbjct: 191 PVGTHEMEEEL 201 >gi|7662088 Rho guanine nucleotide exchange factor (GEF) 12 [Homo sapiens] Length = 1544 Score = 42.0 bits (97), Expect = 0.001 Identities = 26/85 (30%), Positives = 40/85 (47%) Query: 311 KRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKVCQ 370 K +SEE + ++ I D G+G V G P +Q+V G A AG++ Sbjct: 53 KTKSSSEESRSEIYGLVQRCVIIQKDDNGFGLTVSGDNPVFVQSVKEDGAAMRAGVQTGD 112 Query: 371 FVVSVNGLNVLHVDYRTVSNLILTG 395 ++ VNG V H ++ V LI +G Sbjct: 113 RIIKVNGTLVTHSNHLEVVKLIKSG 137 >gi|119120915 rhophilin 1 [Homo sapiens] Length = 670 Score = 41.6 bits (96), Expect = 0.001 Identities = 20/39 (51%), Positives = 25/39 (64%) Query: 339 GWGFVVRGSKPCHIQAVDPSGPAAAAGMKVCQFVVSVNG 377 G+G +RG P I AV P AAAAG+K ++VSVNG Sbjct: 522 GFGLTLRGDSPVLIAAVIPGSQAAAAGLKEGDYIVSVNG 560 >gi|22748695 DEP domain containing 4 [Homo sapiens] Length = 294 Score = 40.0 bits (92), Expect = 0.004 Identities = 24/80 (30%), Positives = 40/80 (50%), Gaps = 8/80 (10%) Query: 44 LHEEKVIKDRRHHLKTYPNCFVAKELIDWLIEHKEASDRETAIKLMQKLADRGIIHHVCD 103 L + IK RRHHL+TY +CF + +D ++ H + T + +G+ H+C Sbjct: 71 LQAQVEIKRRRHHLQTYKDCFTGSDAVDVVLSHLM---QNTCLSSNDISCLKGV--HLCQ 125 Query: 104 ---EHKEFKDVKLFYRFRKD 120 HK F+ V + F+K+ Sbjct: 126 VLMNHKVFEPVGMKKLFKKE 145 >gi|223278403 glutamate receptor, ionotropic, delta 2 (Grid2) interacting protein [Homo sapiens] Length = 1211 Score = 39.3 bits (90), Expect = 0.007 Identities = 31/112 (27%), Positives = 54/112 (48%), Gaps = 3/112 (2%) Query: 295 TLSSSPPVLCNPKSVLKRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQA 354 T +S+PP + + + L PG AR+T + +GF +RG P I++ Sbjct: 246 TRASAPPRRPDEPPPRRASLLVGGLAGPGG--ARRTVRVYKGNKSFGFTLRGHGPVWIES 303 Query: 355 VDPSGPAAAAGMKVCQFVVSVNGLNVLHVDYRTVSNLILTGPRTIVMEVMEE 406 V P PA A +K ++ +NGL++ + + V ++ L G + V+EE Sbjct: 304 VLPGSPADNAALKSGDRILFLNGLDMRNCSHDKVVSM-LQGSGAMPTLVVEE 354 >gi|223633999 DEP domain containing 1B isoform 1 [Homo sapiens] Length = 529 Score = 38.9 bits (89), Expect = 0.009 Identities = 37/154 (24%), Positives = 64/154 (41%), Gaps = 20/154 (12%) Query: 50 IKDRRHHLKTYPNCFVAKELIDWLIEHKEASD-------RETAIKLMQKLADRGIIHHVC 102 ++ R K+Y +CF A E +DWL E S R+ ++L++K +I + Sbjct: 30 LRKHRCRFKSYEHCFTAAEAVDWLHELLRCSQNFGPEVTRKQTVQLLKKFLKNHVIEDIK 89 Query: 103 DE--HKEFKDVKLFYRFRKDDGTFPLDNEVKAF-MRGQRLYEKLMSPE-NTLLQPREEEG 158 + ++F+D + YR FP + +K + + + + PE N L +E Sbjct: 90 GKWGEEDFEDNRHLYR-------FPPSSPLKPYPKKPPNQKDVIKFPEWNDLPPGTSQEN 142 Query: 159 VKYERTFMASEFLDWLVQEGEATTRKEAEQLCHR 192 + M SE W + A A +L HR Sbjct: 143 IPVRPVVMNSEM--WYKRHSIAIGEVPACRLVHR 174 >gi|223633997 DEP domain containing 1B isoform 2 [Homo sapiens] Length = 467 Score = 38.9 bits (89), Expect = 0.009 Identities = 37/154 (24%), Positives = 64/154 (41%), Gaps = 20/154 (12%) Query: 50 IKDRRHHLKTYPNCFVAKELIDWLIEHKEASD-------RETAIKLMQKLADRGIIHHVC 102 ++ R K+Y +CF A E +DWL E S R+ ++L++K +I + Sbjct: 30 LRKHRCRFKSYEHCFTAAEAVDWLHELLRCSQNFGPEVTRKQTVQLLKKFLKNHVIEDIK 89 Query: 103 DE--HKEFKDVKLFYRFRKDDGTFPLDNEVKAF-MRGQRLYEKLMSPE-NTLLQPREEEG 158 + ++F+D + YR FP + +K + + + + PE N L +E Sbjct: 90 GKWGEEDFEDNRHLYR-------FPPSSPLKPYPKKPPNQKDVIKFPEWNDLPPGTSQEN 142 Query: 159 VKYERTFMASEFLDWLVQEGEATTRKEAEQLCHR 192 + M SE W + A A +L HR Sbjct: 143 IPVRPVVMNSEM--WYKRHSIAIGEVPACRLVHR 174 >gi|4506509 regulator of G-protein signalling 12 isoform 2 [Homo sapiens] Length = 1376 Score = 38.9 bits (89), Expect = 0.009 Identities = 25/82 (30%), Positives = 36/82 (43%), Gaps = 6/82 (7%) Query: 311 KRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKVCQ 370 KRP+ P P R G A G+GF + G PC + V PA G++ Sbjct: 9 KRPLPG-----PSPPRVRSVEVARGRA-GYGFTLSGQAPCVLSCVMRGSPADFVGLRAGD 62 Query: 371 FVVSVNGLNVLHVDYRTVSNLI 392 +++VN +NV + V LI Sbjct: 63 QILAVNEINVKKASHEDVVKLI 84 >gi|38327601 regulator of G-protein signalling 12 isoform 1 [Homo sapiens] Length = 1447 Score = 38.9 bits (89), Expect = 0.009 Identities = 25/82 (30%), Positives = 36/82 (43%), Gaps = 6/82 (7%) Query: 311 KRPVTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHIQAVDPSGPAAAAGMKVCQ 370 KRP+ P P R G A G+GF + G PC + V PA G++ Sbjct: 9 KRPLPG-----PSPPRVRSVEVARGRA-GYGFTLSGQAPCVLSCVMRGSPADFVGLRAGD 62 Query: 371 FVVSVNGLNVLHVDYRTVSNLI 392 +++VN +NV + V LI Sbjct: 63 QILAVNEINVKKASHEDVVKLI 84 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.317 0.132 0.386 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 15,928,198 Number of Sequences: 37866 Number of extensions: 722900 Number of successful extensions: 3393 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 56 Number of HSP's successfully gapped in prelim test: 54 Number of HSP's that attempted gapping in prelim test: 3218 Number of HSP's gapped (non-prelim): 181 length of query: 409 length of database: 18,247,518 effective HSP length: 105 effective length of query: 304 effective length of database: 14,271,588 effective search space: 4338562752 effective search space used: 4338562752 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 41 (21.7 bits) S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.