BLASTP 2.2.11 [Jun-05-2005] Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), "Gapped BLAST and PSI-BLAST: a new generation of protein database search programs", Nucleic Acids Res. 25:3389-3402. Query= gi|189217904 RPGRIP1-like isoform b [Homo sapiens] (1235 letters) Database: hs.faa 37,866 sequences; 18,247,518 total letters Searching..................................................done Score E Sequences producing significant alignments: (bits) Value gi|189217904 RPGRIP1-like isoform b [Homo sapiens] 2441 0.0 gi|118442834 RPGRIP1-like isoform a [Homo sapiens] 2402 0.0 gi|112734867 retinitis pigmentosa GTPase regulator interacting p... 629 e-180 gi|58530840 desmoplakin isoform I [Homo sapiens] 93 2e-18 gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] 92 2e-18 gi|55770834 centromere protein F [Homo sapiens] 91 7e-18 gi|148762940 DVL-binding protein DAPLE [Homo sapiens] 87 8e-17 gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa... 86 2e-16 gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s... 86 2e-16 gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ... 86 2e-16 gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 85 4e-16 gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap... 84 1e-15 gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [... 83 2e-15 gi|34577114 cytomatrix protein p110 [Homo sapiens] 82 3e-15 gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 81 7e-15 gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 81 7e-15 gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 81 7e-15 gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 81 7e-15 gi|31982906 cingulin-like 1 [Homo sapiens] 80 9e-15 gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] 80 1e-14 gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] 80 2e-14 gi|156104874 envoplakin [Homo sapiens] 80 2e-14 gi|21735548 centrosomal protein 2 [Homo sapiens] 79 3e-14 gi|4885583 Rho-associated, coiled-coil containing protein kinase... 79 3e-14 gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] 79 3e-14 gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] 78 5e-14 gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] 78 5e-14 gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] 78 5e-14 gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] 78 5e-14 gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] 78 5e-14 >gi|189217904 RPGRIP1-like isoform b [Homo sapiens] Length = 1235 Score = 2441 bits (6327), Expect = 0.0 Identities = 1235/1235 (100%), Positives = 1235/1235 (100%) Query: 1 MSGPTDETAGDLPVKDTGLNLFGMGGLQETSTTRTMKSRQAVSRVSREELEDRFLRLHDE 60 MSGPTDETAGDLPVKDTGLNLFGMGGLQETSTTRTMKSRQAVSRVSREELEDRFLRLHDE Sbjct: 1 MSGPTDETAGDLPVKDTGLNLFGMGGLQETSTTRTMKSRQAVSRVSREELEDRFLRLHDE 60 Query: 61 NILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVH 120 NILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVH Sbjct: 61 NILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVH 120 Query: 121 ELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKF 180 ELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKF Sbjct: 121 ELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKF 180 Query: 181 QDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKE 240 QDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKE Sbjct: 181 QDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKE 240 Query: 241 NEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLR 300 NEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLR Sbjct: 241 NEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLR 300 Query: 301 ISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKE 360 ISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKE Sbjct: 301 ISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKE 360 Query: 361 NYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKL 420 NYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKL Sbjct: 361 NYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKL 420 Query: 421 VQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFL 480 VQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFL Sbjct: 421 VQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFL 480 Query: 481 VKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENL 540 VKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENL Sbjct: 481 VKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENL 540 Query: 541 QQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHL 600 QQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHL Sbjct: 541 QQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHL 600 Query: 601 ERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQ 660 ERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQ Sbjct: 601 ERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQ 660 Query: 661 YLVHVNDLFLQYIQKNTITLEVHQAYSTEYETIAACQLKFHEILEKSGRIFCTASLIGTK 720 YLVHVNDLFLQYIQKNTITLEVHQAYSTEYETIAACQLKFHEILEKSGRIFCTASLIGTK Sbjct: 661 YLVHVNDLFLQYIQKNTITLEVHQAYSTEYETIAACQLKFHEILEKSGRIFCTASLIGTK 720 Query: 721 GDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKGPEHMQSLSQQAPKTAQLS 780 GDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKGPEHMQSLSQQAPKTAQLS Sbjct: 721 GDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKGPEHMQSLSQQAPKTAQLS 780 Query: 781 STDSTDGNLNELHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDD 840 STDSTDGNLNELHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDD Sbjct: 781 STDSTDGNLNELHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDD 840 Query: 841 HMYFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYIGKVNVPLISLAHDRCISGIFELT 900 HMYFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYIGKVNVPLISLAHDRCISGIFELT Sbjct: 841 HMYFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYIGKVNVPLISLAHDRCISGIFELT 900 Query: 901 DHQKHPAGTIHVILKWKFAYLPPSGSITTEDLGNFIRSEEPEVVQRLPPASSVSTLVLAP 960 DHQKHPAGTIHVILKWKFAYLPPSGSITTEDLGNFIRSEEPEVVQRLPPASSVSTLVLAP Sbjct: 901 DHQKHPAGTIHVILKWKFAYLPPSGSITTEDLGNFIRSEEPEVVQRLPPASSVSTLVLAP 960 Query: 961 RPKPRQRLTPVDKKVSFVDIMPHQSDVSQEGSVDEVKENTEKMQQGKDDVSLLSEGQLAE 1020 RPKPRQRLTPVDKKVSFVDIMPHQSDVSQEGSVDEVKENTEKMQQGKDDVSLLSEGQLAE Sbjct: 961 RPKPRQRLTPVDKKVSFVDIMPHQSDVSQEGSVDEVKENTEKMQQGKDDVSLLSEGQLAE 1020 Query: 1021 QSLASSEDETEITEDLEPEVEEDMSASDSDDCIIPGPISKNIKQPSEKIRIEIIALSLND 1080 QSLASSEDETEITEDLEPEVEEDMSASDSDDCIIPGPISKNIKQPSEKIRIEIIALSLND Sbjct: 1021 QSLASSEDETEITEDLEPEVEEDMSASDSDDCIIPGPISKNIKQPSEKIRIEIIALSLND 1080 Query: 1081 SQVTMDDTIQRLFVECRFYSLPAEETPVSLPKPKSGQWVYYNYSNVIYVDKENNKAKRDI 1140 SQVTMDDTIQRLFVECRFYSLPAEETPVSLPKPKSGQWVYYNYSNVIYVDKENNKAKRDI Sbjct: 1081 SQVTMDDTIQRLFVECRFYSLPAEETPVSLPKPKSGQWVYYNYSNVIYVDKENNKAKRDI 1140 Query: 1141 LKAILQKQEMPNRSLRFTVVSDPPEDEQDLECEDIGVAHVDLADMFQEGRDLIEQNIDVF 1200 LKAILQKQEMPNRSLRFTVVSDPPEDEQDLECEDIGVAHVDLADMFQEGRDLIEQNIDVF Sbjct: 1141 LKAILQKQEMPNRSLRFTVVSDPPEDEQDLECEDIGVAHVDLADMFQEGRDLIEQNIDVF 1200 Query: 1201 DARADGEGIGKLRVTVEALHALQSVYKQYRDDLEA 1235 DARADGEGIGKLRVTVEALHALQSVYKQYRDDLEA Sbjct: 1201 DARADGEGIGKLRVTVEALHALQSVYKQYRDDLEA 1235 >gi|118442834 RPGRIP1-like isoform a [Homo sapiens] Length = 1315 Score = 2402 bits (6225), Expect = 0.0 Identities = 1235/1315 (93%), Positives = 1235/1315 (93%), Gaps = 80/1315 (6%) Query: 1 MSGPTDETAGDLPVKDTGLNLFGMGGLQETSTTRTMKSRQAVSRVSREELEDRFLRLHDE 60 MSGPTDETAGDLPVKDTGLNLFGMGGLQETSTTRTMKSRQAVSRVSREELEDRFLRLHDE Sbjct: 1 MSGPTDETAGDLPVKDTGLNLFGMGGLQETSTTRTMKSRQAVSRVSREELEDRFLRLHDE 60 Query: 61 NILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVH 120 NILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVH Sbjct: 61 NILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVH 120 Query: 121 ELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKF 180 ELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKF Sbjct: 121 ELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKF 180 Query: 181 QDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKE 240 QDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKE Sbjct: 181 QDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKE 240 Query: 241 NEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLR 300 NEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLR Sbjct: 241 NEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLR 300 Query: 301 ISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKE 360 ISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKE Sbjct: 301 ISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKE 360 Query: 361 NYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKL 420 NYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKL Sbjct: 361 NYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKL 420 Query: 421 VQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFL 480 VQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFL Sbjct: 421 VQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFL 480 Query: 481 VKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENL 540 VKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENL Sbjct: 481 VKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENL 540 Query: 541 QQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHL 600 QQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHL Sbjct: 541 QQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHL 600 Query: 601 ERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQ 660 ERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQ Sbjct: 601 ERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQ 660 Query: 661 YLVHVNDLFLQYIQKNTITLEVHQAYSTEYETIAACQLKFHEILEKSGRIFCTASLIGTK 720 YLVHVNDLFLQYIQKNTITLEVHQAYSTEYETIAACQLKFHEILEKSGRIFCTASLIGTK Sbjct: 661 YLVHVNDLFLQYIQKNTITLEVHQAYSTEYETIAACQLKFHEILEKSGRIFCTASLIGTK 720 Query: 721 GDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKGPEHMQSLSQQAPKTAQLS 780 GDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKGPEHMQSLSQQAPKTAQLS Sbjct: 721 GDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKGPEHMQSLSQQAPKTAQLS 780 Query: 781 STDSTDGNLNELHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDD 840 STDSTDGNLNELHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDD Sbjct: 781 STDSTDGNLNELHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDD 840 Query: 841 HMYFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYIGKVNVPLISLAHDRCISGIFELT 900 HMYFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYIGKVNVPLISLAHDRCISGIFELT Sbjct: 841 HMYFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYIGKVNVPLISLAHDRCISGIFELT 900 Query: 901 DHQKHPAGTIHVILKWKFAYLPPSGSITTEDLGNFIRSEEPEVVQRLPPASSVSTLVLAP 960 DHQKHPAGTIHVILKWKFAYLPPSGSITTEDLGNFIRSEEPEVVQRLPPASSVSTLVLAP Sbjct: 901 DHQKHPAGTIHVILKWKFAYLPPSGSITTEDLGNFIRSEEPEVVQRLPPASSVSTLVLAP 960 Query: 961 RPKPRQRLTPVDKKVSFVDIMPHQSD---------------------------------- 986 RPKPRQRLTPVDKKVSFVDIMPHQSD Sbjct: 961 RPKPRQRLTPVDKKVSFVDIMPHQSDETSPPPEDRKEISPEVEHIPEIEINMLTVPHVPK 1020 Query: 987 VSQEGSVDEVKENTEKMQQGKDDVSLLSEGQLAEQSLASSEDETEITEDLEPEVEEDMSA 1046 VSQEGSVDEVKENTEKMQQGKDDVSLLSEGQLAEQSLASSEDETEITEDLEPEVEEDMSA Sbjct: 1021 VSQEGSVDEVKENTEKMQQGKDDVSLLSEGQLAEQSLASSEDETEITEDLEPEVEEDMSA 1080 Query: 1047 SDSDDCIIPGPISKNIKQ------------------------------------------ 1064 SDSDDCIIPGPISKNIKQ Sbjct: 1081 SDSDDCIIPGPISKNIKQSLALSPGLGCSSAISAHCNFRLPGSSDFPASASQVDGITGAC 1140 Query: 1065 ----PSEKIRIEIIALSLNDSQVTMDDTIQRLFVECRFYSLPAEETPVSLPKPKSGQWVY 1120 PSEKIRIEIIALSLNDSQVTMDDTIQRLFVECRFYSLPAEETPVSLPKPKSGQWVY Sbjct: 1141 HHTQPSEKIRIEIIALSLNDSQVTMDDTIQRLFVECRFYSLPAEETPVSLPKPKSGQWVY 1200 Query: 1121 YNYSNVIYVDKENNKAKRDILKAILQKQEMPNRSLRFTVVSDPPEDEQDLECEDIGVAHV 1180 YNYSNVIYVDKENNKAKRDILKAILQKQEMPNRSLRFTVVSDPPEDEQDLECEDIGVAHV Sbjct: 1201 YNYSNVIYVDKENNKAKRDILKAILQKQEMPNRSLRFTVVSDPPEDEQDLECEDIGVAHV 1260 Query: 1181 DLADMFQEGRDLIEQNIDVFDARADGEGIGKLRVTVEALHALQSVYKQYRDDLEA 1235 DLADMFQEGRDLIEQNIDVFDARADGEGIGKLRVTVEALHALQSVYKQYRDDLEA Sbjct: 1261 DLADMFQEGRDLIEQNIDVFDARADGEGIGKLRVTVEALHALQSVYKQYRDDLEA 1315 >gi|112734867 retinitis pigmentosa GTPase regulator interacting protein 1 [Homo sapiens] Length = 1286 Score = 629 bits (1622), Expect = e-180 Identities = 435/1336 (32%), Positives = 697/1336 (52%), Gaps = 155/1336 (11%) Query: 1 MSGPTDETAGDLPVKDTGLNLFGMGGLQETSTTRTMKSRQAVSRVSREELEDRFLRLHDE 60 MS D T+GDLPV+D + + + S + MK++ +SR++REELED F RL ++ Sbjct: 1 MSHLVDPTSGDLPVRD----IDAIPLVLPASKGKNMKTQPPLSRMNREELEDSFFRLRED 56 Query: 61 NILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVH 120 ++L+K+ + KQ+D+IKR+ T L+RL GRD+ + E L E Sbjct: 57 HMLVKELSWKQQDEIKRLRTTLLRLT--------------AAGRDLRVAEEAAPLSETAR 102 Query: 121 ELEKQNETLKNRLISAKQQLQTQGY----RQTPYNNVQSRINTGRRKAN-ENAGLQECPR 175 +K + + Q + QG+ Q R+ G R+ + A + E P+ Sbjct: 103 RGQKAGWRQRLSMHQRPQMHRLQGHFHCVGPASPRRAQPRVQVGHRQLHTAGAPVPEKPK 162 Query: 176 KGIKFQDADVAETPHPMFTKYGNSLLEEARGEIR-------------------------- 209 +G + + ++ T P F ++ + E RGE+ Sbjct: 163 RGPRDR---LSYTAPPSFKEHATN---ENRGEVASKPSELVSGSNSIISFSSVISMAKPI 216 Query: 210 -----NLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRD 264 N +++ S Q+EE E + EN + S L+ Q+A + R++I++ Sbjct: 217 GLCMPNSAHIMASNTMQVEEPPKSPE---KMWPKDENFEQRSSLEC-AQKAAELRASIKE 272 Query: 265 NVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRT--------LRISHDALMANGDELNMQ 316 VE+I+L K L E++ +L + + ++QE T L +H+AL+ +EL + Sbjct: 273 KVELIRLKKLLHERNASLVMTKAQLTEVQEAYETLLQKNQGILSAAHEALLKQVNELRAE 332 Query: 317 LKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDS---AFSAA 373 LKE+ K SL+ QL + + ++E Q+R+ DLEKER+LL +NYDKL +S + ++ Sbjct: 333 LKEESKKAVSLKSQLEDVSILQMTLKEFQERVEDLEKERKLLNDNYDKLLESMLDSSDSS 392 Query: 374 HEEQW--KLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQY 431 + W +L +QL+ Q++QL+ L ++L DK ++L L E+ QNE L E + Sbjct: 393 SQPHWSNELIAEQLQQQVSQLQDQLDAELEDKRKVLLELSREKAQNEDLKLEVTNI---- 448 Query: 432 LEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDL 491 L++ +Q EL + +Q D ++ + +L Q+N + + E K L Sbjct: 449 LQKHKQEVELLQNAATISQPPDRQSEPATHPAVL------QENTQIEPSEPKNQE-EKKL 501 Query: 492 ERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQY 551 + + ELQ +HAET ELEKTR+MLI+Q KIN YQ E+EA+ K +N +D++ K+E+ Sbjct: 502 SQVLNELQVSHAETTLELEKTRDMLILQRKINVCYQEELEAMMTKADNDNRDHKEKLERL 561 Query: 552 VHLLDIRAARIHKLEA-----------QLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHL 600 LLD++ RI +LE QLKD+AYGT+ E +P ++ + L Sbjct: 562 TRLLDLKNNRIKQLEGILRSHDLPTSEQLKDVAYGTRPLSLCLETLPAHGDEDKVDISLL 621 Query: 601 ERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQ 660 +GENLFE+HI++ +S L +GD +P TFCTY+FYDFE TP+ G P Y+FTSQ Sbjct: 622 HQGENLFELHIHQAFLTSAALAQAGDTQPTTFCTYSFYDFETHCTPLSVGPQPLYDFTSQ 681 Query: 661 YLVHVNDLFLQYIQKNTITLEVHQAYSTEYETIAACQLKFHEILEKSGRIFCTASLIGTK 720 Y++ + LFL Y+Q+ + L++HQA ++E+ T+AA + F +LE ++ A+LIG Sbjct: 682 YVMETDSLFLHYLQEASARLDIHQAMASEHSTLAAGWICFDRVLETVEKVHGLATLIGAG 741 Query: 721 GDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKGPEHMQSLSQQAPKTAQLS 780 G+ FG +EYW RLR P+ +++ +R KA Y++++ G Q + Sbjct: 742 GE--EFGVLEYWMRLRFPIKPSLQACNKRKKAQVYLSTDVLGGRKAQE---------EEF 790 Query: 781 STDSTDGNLNELHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDD 840 ++S + NEL I I C L+SR QP PY VY+FF F+DHDTAIIP+SN+P F D Sbjct: 791 RSESWEPQ-NELWIEITKCCGLRSRWLGTQPSPYAVYRFFTFSDHDTAIIPASNNPYFRD 849 Query: 841 HMYFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYIGKVNVPLISLAHDRCISGIFELT 900 FPV + DLD YL+ E+LS +VFDD D + Y+G+ VPL+ LA + I G F LT Sbjct: 850 QARFPVLVTSDLDHYLRREALSIHVFDDEDLEPGSYLGRARVPLLPLAKNESIKGDFNLT 909 Query: 901 DHQKHPAGTIHVILKWKFAYLPPSGSI---------TTEDLGNFIRSEE----PEVVQRL 947 D + P G+I V L WKF Y+PP + T+D EE P Q Sbjct: 910 DPAEKPNGSIQVQLDWKFPYIPPESFLKPEAQTKGKDTKDSSKISSEEEKASFPSQDQMA 969 Query: 948 PPASSVSTLVLAPRPKPRQRLTPVDKKVSFVDI--MPHQSDVSQEG-------SVDEVKE 998 P + + KP +K+ V H + +G S++ + Sbjct: 970 SPEVPIEAGQYRSKRKPPHGGERKEKEHQVVSYSRRKHGKRIGVQGKNRMEYLSLNILNG 1029 Query: 999 NTEKM-----QQGKDDVSLLSEG---QLAEQSLASSEDETEITEDLEPEVEEDMS----- 1045 NT + + + S + +G Q E+ + S + E L P +++ S Sbjct: 1030 NTPEQVNYTEWKFSETNSFIGDGFKNQHEEEEMTLSHSALKQKEPLHPVNDKESSEQGSE 1089 Query: 1046 -----ASDSDDCIIPGPISKNIKQPSEKIRIEIIALSL-NDSQVTMDDTIQRLFVECRFY 1099 +DSDD I+P K K SEK+ IEI++L+ +++V D+ I++++VE +FY Sbjct: 1090 VSEAQTTDSDDVIVPPMSQKYPKADSEKMCIEIVSLAFYPEAEVMSDENIKQVYVEYKFY 1149 Query: 1100 SLPAE--ETPVSLPKPKSGQWVYYNYSNVIYVDKENNKAKRDILKAILQKQEMPNRSLRF 1157 LP ETPVSL KP++G+ +++++S VI +D + + +R L +L Q+ L+F Sbjct: 1150 DLPLSETETPVSLRKPRAGEEIHFHFSKVIDLDPQEQQGRRRFLFDMLNGQDPDQGHLKF 1209 Query: 1158 TVVSDPPEDEQDLECEDIGVAHVDLADMFQEGRDLIEQNIDVFDARADGEGIGKLRVTVE 1217 TVVSD P DE+ ECE++G A++ L + + GRD++EQ +D+ IG+L+V+++ Sbjct: 1210 TVVSD-PLDEEKKECEEVGYAYLQLWQILESGRDILEQELDIVSPEDLATPIGRLKVSLQ 1268 Query: 1218 ALHALQSVYKQYRDDL 1233 A L ++YK+ +DL Sbjct: 1269 AAAVLHAIYKEMTEDL 1284 >gi|58530840 desmoplakin isoform I [Homo sapiens] Length = 2871 Score = 92.8 bits (229), Expect = 2e-18 Identities = 126/540 (23%), Positives = 243/540 (45%), Gaps = 76/540 (14%) Query: 47 REELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDV 106 R E R+ + D+ Q K+ +++K++ K ND+K E +R+ D+ Sbjct: 1458 RTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKE---TNDRKCLEDENARLQRVQYDL 1514 Query: 107 EME-----EMIEQLQEKVHELEK---------QNETLKNRLISAKQQLQTQGYRQTPYNN 152 + E I +L+ + EL + Q T+K++ I+ Q + Q Sbjct: 1515 QKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKE--LQLQKQK 1572 Query: 153 VQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGN--SLLEEARGEIRN 210 V+ +N +R A+E++ C RK ++ + + + K N LE+A + Sbjct: 1573 VEEELNRLKRTASEDS----CKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKR 1628 Query: 211 LENVIQSQRGQIEELEHLAEILKTQ--LRRKENEIELSLLQLREQQATDQRSNIR----- 263 E+ ++ QR ++ HL E +TQ LRR +E+E QL ++Q + +++++R Sbjct: 1629 SEDDLRQQRDVLDG--HLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQ 1686 Query: 264 ----DNVEMIKLHKQLVEKSNALSA-MEGKFIQLQEKQRTLRISHDALMANGDELNMQLK 318 D + K +E+ +L+ + + + L+E+ R LR+ +D L E + Sbjct: 1687 KAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEAD---S 1743 Query: 319 EQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQW 378 ++ L QL + S R ELQ INDL++ERE L++ +K A A++ Sbjct: 1744 DKNATILELRSQL---QISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASN---- 1796 Query: 379 KLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQL 438 + Q+ K Q Q+ +S L K ++L++ K + E + + KQ+L Sbjct: 1797 --RIQESKNQCTQVVQERES-LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRL 1853 Query: 439 DELKKRIKLYNQENDINA-----DELSEALLLIKAQKE----QKNGDLSFLVKVDSEINK 489 + K++I +ND+N EA+ I++++E +KN S + ++ +EI + Sbjct: 1854 ECEKQQI-----QNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKR 1908 Query: 490 DLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVE 549 ER R+L+ + ET +LE R+ YQ E++ + ++ ++ + + E Sbjct: 1909 IEERCRRKLEDSTRETQSQLETERSR----------YQREIDKLRQRPYGSHRETQTECE 1958 Score = 60.5 bits (145), Expect = 1e-08 Identities = 107/536 (19%), Positives = 218/536 (40%), Gaps = 64/536 (11%) Query: 65 KQHARKQEDKIKRMATKLIRL---VNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHE 121 KQ+ K +IK + K+ RL + D+KR + R + + +QLQ K + Sbjct: 1094 KQNLDKCYGQIKELNEKITRLTYEIEDEKRRRK-----SVEDRFDQQKNDYDQLQ-KARQ 1147 Query: 122 LEKQN----ETLKNRLISAKQQ--------LQTQGYRQTPYNNVQSRINTG--------R 161 EK+N + + I K+ LQ +G R+ Y N +++ R Sbjct: 1148 CEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLR 1207 Query: 162 RKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQS--QR 219 K + + K I Q D ++ + + +R ++++Q+ QR Sbjct: 1208 NKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQR 1267 Query: 220 GQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKS 279 + EE + +++ +K+ +E+ L Q+ +Q++ D N R + + K + +K+ Sbjct: 1268 RRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSED---NARHKQSLEEAAKTIQDKN 1324 Query: 280 NALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQ-LHSMKFS- 337 + ++ +F + +++ + N DE + LK Q ++ K +H + Sbjct: 1325 KEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQK 1384 Query: 338 ERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHE--------EQWKLKEQQLKVQI 389 E + +I++L +E L E +L ++ +Q K ++ + Sbjct: 1385 EEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRK 1444 Query: 390 AQLETALKSDLTDKTEILDRLKTERDQNEKLVQE-NRELQ-LQYLEQKQQLDE------- 440 QLE L+ +TE R K D K +Q+ N+E++ L+ L K+ D Sbjct: 1445 QQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDEN 1504 Query: 441 -LKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLER---SMR 496 +R++ Q+ + +A E L + + + + D + + + ++D+ R S++ Sbjct: 1505 ARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLK 1564 Query: 497 ELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTR-------KMENLQQDYE 545 ELQ + +EL + + K + E+E + R K+ NL Q E Sbjct: 1565 ELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLE 1620 Score = 55.5 bits (132), Expect = 3e-07 Identities = 104/494 (21%), Positives = 207/494 (41%), Gaps = 57/494 (11%) Query: 152 NVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYG----NSLLEEARGE 207 N+ S I+ R K+ E + E IK + +A + T ++++ G Sbjct: 932 NLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGV 991 Query: 208 IRNLENVIQSQRGQIEELEH-------LAEILKTQLRRKENEIELSLLQLREQQATDQRS 260 I L+ IE L L+E+LK+ K ++ +L+ + A D S Sbjct: 992 I--LQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANS 1049 Query: 261 NIRDNVEMIKLHKQLVEKSNA-LSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKE 319 +N K Q ++K A S + K L+E +R + + N D+ Q+KE Sbjct: 1050 ---ENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKE 1106 Query: 320 QRLKCCSL----EKQLHSMKFSERRIEELQDRINDLEKERELLKEN--YDKLYDSAFSAA 373 K L E + K E R ++ ++ + L+K R+ KEN + KL Sbjct: 1107 LNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKL-------- 1158 Query: 374 HEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLE 433 E + +KE++ +++ +L L+ + T K E + L R+ N E+ + Sbjct: 1159 -ESEKAIKEKEYEIE--RLRVLLQEEGTRKREYENELAKVRN------HYNEEMSNLRNK 1209 Query: 434 QKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDL-SFLVKVDSEINKDLE 492 + +++ K IK + + + ++ L L + ++N DL +V+++ I + E Sbjct: 1210 YETEINITKTTIKEISMQKEDDSKNLRNQL----DRLSRENRDLKDEIVRLNDSILQATE 1265 Query: 493 RSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYV 552 + R AE +K IMQ K + ++E++ V ++ ++ +E+ Sbjct: 1266 QRRR------AEENALQQKACGSEIMQKK--QHLEIELKQVMQQRSEDNARHKQSLEEAA 1317 Query: 553 HLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENLFEIHIN 612 + + I +L+A+ ++ A ++++++ E+ + +DE I + + EI+I Sbjct: 1318 KTIQDKNKEIERLKAEFQEEA--KRRWEYENEL--SKVRNNYDEEIISLKNQFETEINIT 1373 Query: 613 KVTFSSEVLQASGD 626 K T +Q D Sbjct: 1374 KTTIHQLTMQKEED 1387 Score = 33.1 bits (74), Expect = 1.7 Identities = 49/244 (20%), Positives = 109/244 (44%), Gaps = 18/244 (7%) Query: 323 KCCSLEKQLHSMKFSERRIEELQDR-INDLEKERELLK-----ENYDKLYDSAFSAAHEE 376 K C L+ ++ + I + D +N L R LL+ E+ K+Y++ + EE Sbjct: 738 KYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLT--EEE 795 Query: 377 QWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKL-VQENRELQLQYLEQK 435 L +++ L+ +K+DL K +L +KTE + +++ Q +++ L L+ Sbjct: 796 TVCLDLDKVEAYRCGLKK-IKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLG 854 Query: 436 ---QQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLE 492 +++ +L R + +++ D +L + + ++ ++ +L D++ +D Sbjct: 855 KFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLY--DAKRRQD-- 910 Query: 493 RSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYV 552 S+ ++ + TV + L + +D EV+ + N +DYEL++ Y Sbjct: 911 -SLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYT 969 Query: 553 HLLD 556 L+ Sbjct: 970 SGLE 973 >gi|55770888 early endosome antigen 1, 162kD [Homo sapiens] Length = 1411 Score = 92.4 bits (228), Expect = 2e-18 Identities = 143/653 (21%), Positives = 279/653 (42%), Gaps = 81/653 (12%) Query: 12 LPVKDTGLNLFGMGGLQETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQ 71 L +T L+ + ++ T+ +K + + L+ F +L + +QH + Sbjct: 353 LSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQL 412 Query: 72 EDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKN 131 + +I ++ +KL L +++ E G ++E + EK+ + E+Q L+ Sbjct: 413 QSEINQLHSKL--LETERQLGEAHG----------RLKEQRQLSSEKLMDKEQQVADLQL 460 Query: 132 RLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHP 191 +L ++QL+ + T +Q +++ +++ E LQ+ ++ D+ + Sbjct: 461 KLSRLEEQLKE---KVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQ 517 Query: 192 MFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLR 251 + K +I+NLE ++Q + I LE E L +++ E E + L QL+ Sbjct: 518 IGDK---------DQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAV-LNQLQ 567 Query: 252 EQQATDQRSNIRDNVEMIKLHKQLVEKSNA-LSAMEGKFIQLQEKQRTLRISHD---ALM 307 E+ T Q ++ +L ++L +S + A E Q+QE++ LR + D +L Sbjct: 568 EKNHTLQE-------QVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLE 620 Query: 308 ANGDELNMQLKEQRLKCCSLEKQLHS-----MKFSERRIEELQDRINDLEKERELLKENY 362 + +ELN QL E + K L+ Q+ + + + + D N L+ + L+ Sbjct: 621 TSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQ--- 677 Query: 363 DKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKS------DLTDKTEILDRLKTERDQ 416 DK + +Q K Q + +QLE+ LK L KTE L+ + + Sbjct: 678 DKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEA 737 Query: 417 NEKLVQENRELQLQYLEQKQQLD--------ELKKRIKLYNQ---ENDINADELSEALLL 465 + V+ ++E LQ L+Q++QL+ EL K++++ + ++ + SEAL Sbjct: 738 DSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALES 797 Query: 466 IKAQKEQKNGDLSFLVKVD------------SEINKDLERSMRELQATHAE---TVQELE 510 IK QK K + ++K D E+N ++ ++ ELQ E + EL Sbjct: 798 IK-QKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELS 856 Query: 511 KTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLK 570 ++ L K+ + E E +K + D E ++ H L ++ K + +LK Sbjct: 857 TVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELK 916 Query: 571 DIAYGTK----QYKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSE 619 K Q K + M + + + E+ E + +IN++ SSE Sbjct: 917 KSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSE 969 Score = 69.3 bits (168), Expect = 2e-11 Identities = 108/520 (20%), Positives = 220/520 (42%), Gaps = 66/520 (12%) Query: 48 EELEDRFLRLHDENILLKQ--HARKQEDKIKR--MATKLIRLVNDKKRYERVGGGPKRLG 103 E ++ + + +E +LKQ QE KI+ + ++ V + ++ + Sbjct: 796 ESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVK---------- 845 Query: 104 RDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRK 163 +E E ++ +L +L K +++LKN +++ Q + + Sbjct: 846 --MEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV 903 Query: 164 ANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEE---ARGEIRNLENVIQSQRG 220 EN L+E +K +K E H + + NS+ E+ A+ ++ E Q +G Sbjct: 904 QMENT-LKE--QKELKKSLEKEKEASHQLKLEL-NSMQEQLIQAQNTLKQNEKEEQQLQG 959 Query: 221 QIEELEHLAEILKTQLRRKENEIELSLLQLRE------QQATDQRSNIRDNVEMIKLHKQ 274 I EL+ +E K Q+ + E+++++LQ E QQ T + E I + + Sbjct: 960 NINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQN 1019 Query: 275 LVEKSN-ALSAMEGKFI-----------QLQEKQRTLRISHDALMANGDELNMQLKE-QR 321 EKS ++ F L+ + L ++ + L++N +++ Q K Q Sbjct: 1020 NYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQE 1079 Query: 322 LKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLK 381 LK + S K E++++E + D++KE+ L ++ +L + A E+ K + Sbjct: 1080 LKTAKATLEQDSAK-KEQQLQERCKALQDIQKEKSLKEK---ELVNEKSKLAEIEEIKCR 1135 Query: 382 EQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDEL 441 +++ +I +L LKS K E + + +D + L+Q+ ELQ + D L Sbjct: 1136 QEK---EITKLNEELKSH---KLESIKEITNLKDAKQLLIQQKLELQ-------GKADSL 1182 Query: 442 KKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQAT 501 K ++ + I D++ K ++E K + K+ SEI K+ E M++ + Sbjct: 1183 KAAVEQEKRNQQILKDQVK------KEEEELKKEFIEKEAKLHSEI-KEKEVGMKKHEEN 1235 Query: 502 HAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQ 541 A+ ++ L K + Q V + ++ ++L+ Sbjct: 1236 EAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLR 1275 Score = 67.0 bits (162), Expect = 1e-10 Identities = 85/416 (20%), Positives = 186/416 (44%), Gaps = 52/416 (12%) Query: 198 NSLLEEARGEIRNLENVI---QSQRGQIEELEHLAEILKTQLRRKENEI------ELSLL 248 + L+ ++ E+++LE + Q++ I++++ L E QL + +I E SL Sbjct: 127 DGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLR 186 Query: 249 QLREQQATDQRSNIRDNVEMIK-LHKQLVEKSNA--LSAMEGKFIQLQEKQRTLRISHDA 305 + EQ+ T + +I+ L +L+++ ++ ++ + +Q+Q + + + Sbjct: 187 EAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERER 246 Query: 306 LMANGDELNMQLKEQRLKCCSLEKQLHSMKFS-----------ERRIEELQDRINDLEKE 354 ++L + K+ + + S E + ++ + +++L+ +N+L ++ Sbjct: 247 ---ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQK 303 Query: 355 RELLKENYDKLYD--SAFSAAHEEQWKLKEQ------QLKVQIAQLETALKSDLTDKTEI 406 + L EN K + H E+ K+ Q + QL++ L + T I Sbjct: 304 NQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRI 363 Query: 407 LDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQ-----ENDINADELSE 461 L + + +KL +E E++ +Y K + +L+++ + Q +++IN +L Sbjct: 364 HVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEIN--QLHS 421 Query: 462 ALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQEL-EKTRNMLIMQH 520 LL + Q + +G L ++ SE D E+ + +LQ + ++L EK N +QH Sbjct: 422 KLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQH 481 Query: 521 KINKDYQMEVE------AVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLK 570 +++K Q E + T K+ Q D +EQ + + + +I LEA L+ Sbjct: 482 QLDKTKQQHQEQQALQQSTTAKLREAQND----LEQVLRQIGDKDQKIQNLEALLQ 533 Score = 65.5 bits (158), Expect = 3e-10 Identities = 100/556 (17%), Positives = 232/556 (41%), Gaps = 52/556 (9%) Query: 49 ELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEM 108 +LE ++ + L+Q + E +IK++ + + K++ + ++L D+E+ Sbjct: 706 QLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLEL 765 Query: 109 E--EMIEQLQEKVH-------ELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINT 159 E+ +QL+ + +L+K++E L++ +Q + + + + + Sbjct: 766 RATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKI 825 Query: 160 GRRKANENAGLQECPRKGIKFQ-DADVAE--TPHPMFTKYGNSLLEEARGEIRNLENVIQ 216 + N + +K + +A + E T +K +SL + E Q Sbjct: 826 QHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSL----KNSKSEFEKENQ 881 Query: 217 SQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLV 276 + I +LE + LK QL+ + +L++ ++ ++ + +E+ + +QL+ Sbjct: 882 KGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLI 941 Query: 277 EKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQL-HSMK 335 + N L E + QLQ L+ S + + L +LK L+ LE +L + Sbjct: 942 QAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLT 1001 Query: 336 FSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETA 395 + + + +++I+ L+ E +E + +L + E + Q LK +L A Sbjct: 1002 QAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFY--GRESELLATRQDLKSVEEKLSLA 1059 Query: 396 LKSDLTDKTEILDRLKTERDQNEKLVQE----NRELQLQYLEQKQQLDELKKRIKLYNQE 451 + ++++ +I KL+QE L+ +++QQL E K ++ +E Sbjct: 1060 QEDLISNRNQI--------GNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKE 1111 Query: 452 NDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELE- 510 + EL + L+ + ++ K++ + EL++ E+++E+ Sbjct: 1112 KSLKEKEL-----------VNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITN 1160 Query: 511 -KTRNMLIMQHKIN-----KDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHK 564 K L++Q K+ + VE R + L+ + + E+ + A++H Sbjct: 1161 LKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLH- 1219 Query: 565 LEAQLKDIAYGTKQYK 580 +++K+ G K+++ Sbjct: 1220 --SEIKEKEVGMKKHE 1233 Score = 62.8 bits (151), Expect = 2e-09 Identities = 113/531 (21%), Positives = 217/531 (40%), Gaps = 63/531 (11%) Query: 29 ETSTTRTMKSRQAVSRVSRE--ELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLV 86 +T+ T K + + E ++D+ ++ D K K+ K K L + Sbjct: 835 QTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTC 894 Query: 87 NDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQL-QTQGY 145 + K +V L E+++ +E+ +E H+L+ + +++ +LI A+ L Q + Sbjct: 895 KELKHQLQVQM-ENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKE 953 Query: 146 RQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEAR 205 Q N+ + +K + LQ + + Q ++ T+ L E + Sbjct: 954 EQQLQGNINELKQSSEQKKKQIEALQGELKIAV-LQKTELENKLQQQLTQAAQELAAE-K 1011 Query: 206 GEIRNLENVIQSQRGQIEELE-----HLAEILKTQLRRKENEIELSLLQLREQQATDQRS 260 +I L+N + + ++L+ +E+L T+ K E +LSL Q +Q Sbjct: 1012 EKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIG 1071 Query: 261 NIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLR-ISHDALMANGDELNMQLKE 319 N ++ +K K +E+ +A QLQE+ + L+ I + + + +N + K Sbjct: 1072 NQNKLIQELKTAKATLEQDSAKKEQ-----QLQERCKALQDIQKEKSLKEKELVNEKSKL 1126 Query: 320 QRLK--CCSLEKQLHSM--KFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSA-AH 374 ++ C EK++ + + ++E +++ I +L+ ++LL + +L A S A Sbjct: 1127 AEIEEIKCRQEKEITKLNEELKSHKLESIKE-ITNLKDAKQLLIQQKLELQGKADSLKAA 1185 Query: 375 EEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQEN---------- 424 EQ K +Q LK Q+ + E LK + +K L E++ K +EN Sbjct: 1186 VEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITA 1245 Query: 425 ------------RELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQ 472 + Q + E ++Q D+L+ I + N DE Sbjct: 1246 LNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDE-------------- 1291 Query: 473 KNGDLSFLVKVDSEINKDLERSMRELQATHAET---VQELEKTRNMLIMQH 520 + L +K + EI K L+ + ELQ T VQEL + L ++H Sbjct: 1292 RRALLERCLKGEGEIEK-LQTKVLELQRKLDNTTAAVQELGRENQSLQIKH 1341 >gi|55770834 centromere protein F [Homo sapiens] Length = 3114 Score = 90.9 bits (224), Expect = 7e-18 Identities = 144/652 (22%), Positives = 294/652 (45%), Gaps = 111/652 (17%) Query: 37 KSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKI-----------KRMATKLI-- 83 K QA+S +++ ELE++ +L+ E LL + + + ++ K + L+ Sbjct: 2042 KDSQALS-LTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEK 2100 Query: 84 -----RLVNDKKRYERVGGGPKRLGRDVEMEEMIE-QLQEKVHELEKQNETLKNRLISAK 137 RL + ++ ++ G ++L +E +E + + EK+ E E++N++LK+++ + + Sbjct: 2101 GEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLE 2160 Query: 138 QQLQTQGYRQT----PYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMF 193 ++LQ Q N ++ + T + + E A + +K + D Sbjct: 2161 RELQMSEENQELVILDAENSKAEVETLKTQIEEMA-------RSLKVFELD--------- 2204 Query: 194 TKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQ 253 L R E NL IQ ++GQ+ EL+ L K+ L KE + +Q++E+ Sbjct: 2205 -------LVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQ----AEIQIKEE 2253 Query: 254 QATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDEL 313 T VEM L QL E + A++A+ G QE + S D + +L Sbjct: 2254 SKT--------AVEM--LQNQLKELNEAVAALCGD----QEIMKATEQSLDPPIEEEHQL 2299 Query: 314 NMQLKEQRLKCCSLEKQ----LHSMKFSERRIEELQDRINDLEKERELLKENYD-KLYDS 368 +++ R + + EK+ L +K SE + L+ R+ +LE+E E+ + N + ++ Sbjct: 2300 RNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEA 2359 Query: 369 AFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQ----------NE 418 S E K K + + + LE + + ++K + + L+ E+++ E Sbjct: 2360 ENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFE 2419 Query: 419 KLVQENRELQLQYLEQ--------KQQLDELKKRI-KLYNQENDINADELS-----EALL 464 ++QE + ++Q E+ + QL EL +R+ L+N + A E + E L Sbjct: 2420 NILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLE 2479 Query: 465 LIKAQ-----KEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQ 519 L KAQ E KN + V+ I +++E ++L+ + +E+ + +N + Q Sbjct: 2480 LEKAQLLQGLDEAKNNYIVLQSSVNGLI-QEVEDGKQKLE----KKDEEISRLKNQIQDQ 2534 Query: 520 HK-INKDYQMEVEAVTRKMENLQ-QDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTK 577 + ++K Q+E E K +NL+ ++ +++EQ + +L + A L+ L+ + K Sbjct: 2535 EQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNA---SLQDTLEVLQSSYK 2591 Query: 578 QYKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSEVLQ--ASGDK 627 + + E+ D + ++ + E + ++++ + LQ SG+K Sbjct: 2592 NLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEK 2643 Score = 86.3 bits (212), Expect = 2e-16 Identities = 127/632 (20%), Positives = 278/632 (43%), Gaps = 69/632 (10%) Query: 36 MKSRQAVSRVSREELE--DRFLRLHDENI-LLKQHARKQEDKIKRMATKLIRLVNDKKRY 92 +K R+ + ++++E +R L++ +EN L+ A + +++ + T++ + K + Sbjct: 2142 LKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVF 2201 Query: 93 ERVGGGPKRLGRDVEMEEMIEQLQEK---VHELEKQNETLKNRLISAKQ-QLQTQGYRQT 148 E + E E + +Q+QEK + EL+K + K+ L +Q ++Q + +T Sbjct: 2202 EL-----DLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKT 2256 Query: 149 PYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEI 208 +Q+++ G QE + + D + E H + + +E+ R + Sbjct: 2257 AVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEE-HQL-----RNSIEKLRARL 2310 Query: 209 RNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEM 268 E Q++E EH A++LK ++ E E+E++ + ++ A + N + VE Sbjct: 2311 EADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIA--RTNQEHAALEAENSKGEVET 2368 Query: 269 IKLHKQLVEKSNALSAMEGKFIQLQEKQRTL---------RISHDALMANGDELNMQLKE 319 +K ++ + +L +E + ++ ++ L RIS ++ + E +Q KE Sbjct: 2369 LKA--KIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKE 2426 Query: 320 QRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWK 379 Q K EK +M+ + +++EL +R+ L ++E K L ++ E + Sbjct: 2427 QE-KVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNL------SSQVECLE 2479 Query: 380 LKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLD 439 L++ QL + L+ A + + ++ + ++ D +KL +++ E+ + Q Q + Sbjct: 2480 LEKAQL---LQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEIS-RLKNQIQDQE 2535 Query: 440 ELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQ 499 +L ++ E+ + ++ E L + + EQK ++V N L+ ++ LQ Sbjct: 2536 QLVSKLSQVEGEHQLWKEQNLE-LRNLTVELEQK-------IQVLQSKNASLQDTLEVLQ 2587 Query: 500 ATHAETVQELEKTR-NMLIMQHKINK------DYQMEVEAVTRKMENLQQDYELKVEQYV 552 +++ ELE T+ + + K+NK + Q E+ + +K LQ++ + + Sbjct: 2588 SSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLA 2647 Query: 553 HLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENLFEIHIN 612 L + I + QLK++ + K + M D V++ + + E E +H Sbjct: 2648 GELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEK-EGKVREEIAEYQLRLH-- 2704 Query: 613 KVTFSSEVLQASGDKEPVTFCTYAFYDFELQT 644 +A + + T Y+ E+QT Sbjct: 2705 ---------EAEKKHQALLLDTNKQYEVEIQT 2727 Score = 77.4 bits (189), Expect = 8e-14 Identities = 163/759 (21%), Positives = 304/759 (40%), Gaps = 117/759 (15%) Query: 43 SRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRL 102 ++V E E + DE + + K + KL +L D +R R Sbjct: 325 AKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLS-CQRQNAESARC 383 Query: 103 GRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTP--YNNVQSRIN-- 158 + +++E ++ QE++ ++ +TL I K +L TQ +Q +N +Q+ ++ Sbjct: 384 SLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARL-TQELQQAKNMHNVLQAELDKL 442 Query: 159 TGRRKANENAGLQECPRKGIK----FQDADVAETP---HPMFTKYGNSLL-----EEAR- 205 T ++ EN L+E +K + FQ + + E K N+LL ++AR Sbjct: 443 TSVKQQLEN-NLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKARE 501 Query: 206 -----GEIRNLENVIQSQRGQIEEL-------EHLAEILKTQLRRKENEIELSLLQLREQ 253 E++N++ + + EE+ E + L+ ++ ++EN + L L+L Sbjct: 502 VCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVA 561 Query: 254 QATDQRSNIRD-------NVEMI--KLHKQLVEKSNALSAMEGKFIQLQE--KQRTL--- 299 QR +D ++E + KL K E LSA+E K + +E +++TL Sbjct: 562 DLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSC 621 Query: 300 -RISHDALMA--NGDELNMQLKEQRLKCCSLEKQLHSMKFSER-------------RIEE 343 + ++ L+ ++ N+Q K L+ C +Q+ S +++ER I Sbjct: 622 WKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRN 681 Query: 344 LQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWK-----LKEQQLKVQIAQLE---TA 395 L + ++ E E K Y +L A + + Q + LK QL Q+ LE Sbjct: 682 LHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQL 741 Query: 396 LKSDLTDKTEILDRLKTERDQNEKLVQE-------NRELQLQYLEQKQQLDELKKRIKLY 448 L +++ DK L E + L++ N + Q L QQ + Sbjct: 742 LSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANII 801 Query: 449 NQENDINADELSEALLLIKAQKEQKNG--------DLSFLVKVDSEINKDLERSMRELQA 500 ++ + E SE L +A + KN L F ++ ++N DL++ EL Sbjct: 802 GEQGSM-PSERSECRL--EADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQ 858 Query: 501 THAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAA 560 E + L K M +Q V ++++ LQ+D Q V + A Sbjct: 859 IKGEIEENLMKAEQM----------HQSFVAETSQRISKLQED--TSAHQNVVAETLSAL 906 Query: 561 RIHKLEAQLKDIAYGTKQYKF----KPEIMPDDSVDE---FDETIHLERGENLFEIHINK 613 + E QL + T+Q + K + +DS+ E ET+ LE+ E I +NK Sbjct: 907 ENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNK 966 Query: 614 VTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQYLVHVNDLFLQYI 673 E+ Q +G + + + +++ N+ + +++L QY Sbjct: 967 REI-EELTQENGTLKEIN------ASLNQEKMNLIQKSESFANYIDEREKSISELSDQYK 1019 Query: 674 QKNTITLEVHQAYSTEYETIAACQLKFHEILEKSGRIFC 712 Q+ I L+ + YE ++ K+ EK+ ++ C Sbjct: 1020 QEKLILLQRCEETGNAYEDLSQ---KYKAAQEKNSKLEC 1055 Score = 73.6 bits (179), Expect = 1e-12 Identities = 129/581 (22%), Positives = 229/581 (39%), Gaps = 89/581 (15%) Query: 44 RVSREELEDRFLRLHDENILLKQHARKQE-----DKIKRMATKLIRLVND-----KKRYE 93 RV E E R + E+ L+ K E KI+ M L L D ++ Sbjct: 2337 RVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKEN 2396 Query: 94 RVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQ----GYRQTP 149 K R E+E + + + E E++ +K + +A + LQTQ R Sbjct: 2397 LTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAA 2456 Query: 150 YNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARG--- 206 +N Q + + E + + Q D A+ + + N L++E Sbjct: 2457 LHNDQEACKAKEQNLSSQVECLELEKAQL-LQGLDEAKNNYIVLQSSVNGLIQEVEDGKQ 2515 Query: 207 -------EIRNLENVIQSQR------GQIEELEHLAEILKTQLRRKENEIELSLLQLREQ 253 EI L+N IQ Q Q+E L + +LR E+E + L+ + Sbjct: 2516 KLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSK 2575 Query: 254 QATDQRS---------NIRDNVEMIKLHKQ-LVEKSNALSAMEGKFIQLQEKQRTLRISH 303 A+ Q + N+ + +E+ K+ K VEK N ++A E E QR + H Sbjct: 2576 NASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKE------TELQREM---H 2626 Query: 304 DALMANGDELNMQLKEQRLKCCS-LEKQLHSMKFSERRIEELQDRINDLEKERELLKENY 362 + EL +L ++ + L+ L +K S+ +++EL ++L+K + + ++ Sbjct: 2627 EMAQKTA-ELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQ 2685 Query: 363 DKLYDSAFSAAHEEQWKLKEQQLKVQIAQLET---------ALKSDLTDKTEILDRLKTE 413 + E Q +L E + K Q L+T + LT K E L K E Sbjct: 2686 VEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLE 2745 Query: 414 RDQNEKLVQENRELQLQYLEQKQQLDELKK----RIKLYNQENDINADELSEALLLIKAQ 469 D L EL Q L+ELKK +K NQ +K + Sbjct: 2746 IDL---LKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQ---------------LKKE 2787 Query: 470 KEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQME 529 E+ G + L+K ++ ++ E +EL + + QE +KT +M K++ + E Sbjct: 2788 NERAQGKMKLLIKSCKQLEEEKEILQKEL--SQLQAAQEKQKTGT--VMDTKVD-ELTTE 2842 Query: 530 VEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLK 570 ++ + +E ++ + +++Y LL I ++ K + L+ Sbjct: 2843 IKELKETLEEKTKEADEYLDKYCSLL-ISHEKLEKAKEMLE 2882 Score = 65.9 bits (159), Expect = 2e-10 Identities = 93/529 (17%), Positives = 229/529 (43%), Gaps = 37/529 (6%) Query: 37 KSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVG 96 K Q + ++ E+L+ L + + +K+E I+++ KL + + K Sbjct: 543 KINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSAL 602 Query: 97 GGPKRLGRDVEMEEMI-----EQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYN 151 K+ +++ E+ + + ++ + ++E + E L++++ + L+TQ + YN Sbjct: 603 ELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYN 662 Query: 152 NVQSRINTGRRKAN-ENAGLQEC-PRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIR 209 + R + E L K ++ + +A ++ + ++ + EI Sbjct: 663 ERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSD---QKHQKEIE 719 Query: 210 NLENVIQSQRGQIEELEHLAEILKTQLRRKE---NEIELSLLQLREQQATDQRSNIRDNV 266 N+ GQ+E+LEH ++L ++ K+ ++ LR+ + S + + Sbjct: 720 NMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTN-- 777 Query: 267 EMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCS 326 + H++ + + AM F + +Q ++ + E ++ + Sbjct: 778 ---EDHQRSLLAFDQQPAMHHSFANIIGEQ-------GSMPSERSECRLEADQSPKNSAI 827 Query: 327 LEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLK 386 L+ ++ S++FS +E + +DL+K+ E L + ++ ++ A Q + E + Sbjct: 828 LQNRVDSLEFS---LESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQR 884 Query: 387 VQIAQLETALKSDLTDKTEILDRLKTERDQ----NEKLVQENRELQLQYLEQKQQLDELK 442 + Q +T+ ++ E L L+ + + N+K+ E E+Q + + L++ Sbjct: 885 ISKLQEDTSAHQNVV--AETLSALENKEKELQLLNDKVETEQAEIQ-ELKKSNHLLEDSL 941 Query: 443 KRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATH 502 K ++L ++ + E+S + L K + E+ + L ++++ +N++ + ++ + + Sbjct: 942 KELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQE-KMNLIQKSESF 1000 Query: 503 AETVQELEKTRNMLIMQHKINKDYQME-VEAVTRKMENLQQDYELKVEQ 550 A + E EK+ + L Q+K K ++ E E+L Q Y+ E+ Sbjct: 1001 ANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEK 1049 Score = 55.5 bits (132), Expect = 3e-07 Identities = 86/400 (21%), Positives = 179/400 (44%), Gaps = 63/400 (15%) Query: 65 KQHARKQEDKIKRMATKLI---RLVNDKKRYERVGGGPKRLGRD--VEMEEMIEQLQEKV 119 KQ K++++I R+ ++ +LV+ + E G +L ++ +E+ + +L++K+ Sbjct: 2514 KQKLEKKDEEISRLKNQIQDQEQLVSKLSQVE----GEHQLWKEQNLELRNLTVELEQKI 2569 Query: 120 HELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIK 179 L+ +N +L++ L Q+ Y N+++ + K ++ + +++ + K Sbjct: 2570 QVLQSKNASLQDTL----------EVLQSSYKNLENELEL--TKMDKMSFVEKVNKMTAK 2617 Query: 180 FQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRK 239 + ++ H M K L EE GE L +Q +EE++ + LK +L + Sbjct: 2618 --ETELQREMHEMAQKTAE-LQEELSGEKNRLAGELQLL---LEEIKSSKDQLK-ELTLE 2670 Query: 240 ENEIELSLLQLREQQATDQRSNIRDNV--------EMIKLHKQLVEKSNALSAME----- 286 +E++ SL + + Q ++ +R+ + E K H+ L+ +N +E Sbjct: 2671 NSELKKSLDCMHKDQV-EKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYR 2729 Query: 287 GKFIQLQEKQRTLRISHDALMANGDELNMQLKE-----QRLKCCSLE--KQLHSMKFSER 339 K +E + ++ D L ++ +ELN LK + LK ++ K ++ +K Sbjct: 2730 EKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENE 2789 Query: 340 RIEE----LQDRINDLEKERELLKENYDKLYDSAFSAAHEEQ-----WKLKEQQLKVQIA 390 R + L LE+E+E+L++ +L AA E+Q K +L +I Sbjct: 2790 RAQGKMKLLIKSCKQLEEEKEILQKELSQL-----QAAQEKQKTGTVMDTKVDELTTEIK 2844 Query: 391 QLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQ 430 +L+ L+ + E LD+ + +EKL + L+ Q Sbjct: 2845 ELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQ 2884 Score = 53.5 bits (127), Expect = 1e-06 Identities = 81/373 (21%), Positives = 157/373 (42%), Gaps = 59/373 (15%) Query: 227 HLAEILKTQ---LRRKENEIELSLLQLREQQATDQRSNIRD-NVEMIKLHKQLVEKSNAL 282 HL + LK Q LR K NE+EL L Q E++ Q + ++ +++ K +L+EK L Sbjct: 278 HLLDQLKAQNQELRNKINELELRL-QGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVL 336 Query: 283 SAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKC----CSLEKQLHSMKFSE 338 + + ++ + + AL +L L QR CSLE+++ Sbjct: 337 NKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIK------ 390 Query: 339 RRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEE--QWKLKEQQLKVQIAQLETAL 396 EKE+E +E + +F +E Q K + Q Q + L Sbjct: 391 -------------EKEKEFQEELSRQ--QRSFQTLDQECIQMKARLTQELQQAKNMHNVL 435 Query: 397 KSDLTDKTEILDRLKTERDQ-NEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDIN 455 +++L T + +L+ ++ +KL + + Q +++ +EL++ ++ +EN+ Sbjct: 436 QAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKE----NELRRSMEEMKKENN-- 489 Query: 456 ADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNM 515 L+K+ EQK ++ L I + L +S + A+ + R+ Sbjct: 490 ---------LLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRD- 539 Query: 516 LIMQHKIN-KDYQMEVE------AVTRKMENLQQDYELKVEQYVHLLDIRAARIHK-LEA 567 +Q KIN ++ + +E A K + QD K E ++ L+ + ++ K +A Sbjct: 540 --LQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKA 597 Query: 568 QLKDIAYGTKQYK 580 L + K+Y+ Sbjct: 598 LLSALELKKKEYE 610 Score = 52.4 bits (124), Expect = 3e-06 Identities = 83/328 (25%), Positives = 148/328 (45%), Gaps = 22/328 (6%) Query: 230 EILKTQLRRKENEIE-LSLLQLREQQATDQRSNIRDNVEM-IKLHKQLVEKSNALSA-ME 286 +I QLR KE E L LL + E + S + + E+ KLH Q V+ + A +E Sbjct: 1768 DIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIE 1827 Query: 287 GKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQD 346 + I + K+ +S + D + + + + + + ++H+ K S I + Sbjct: 1828 LEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVA 1887 Query: 347 RINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEI 406 ++ND KER L EN S ++ E L+ VQ +L L+ D +K ++ Sbjct: 1888 KVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKL--CLEKDNENKQKV 1945 Query: 407 LDRLKTERDQNEKLVQENREL--QLQYLEQK-QQLDELKKRIKLYNQENDINADELSEAL 463 + L+ E + E +L +L + +K LD+L +++K QE + + E + Sbjct: 1946 IVCLEEEL---SVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCI 2002 Query: 464 LLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQ-HKI 522 + +A+ ++K L L SE+ KD +LQ+ ++ Q L T+ L Q ++ Sbjct: 2003 QVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDS-QALSLTKCELENQIAQL 2061 Query: 523 NKDYQMEVEAVTRKMENLQ-----QDYE 545 NK E E + ++ E+LQ DYE Sbjct: 2062 NK----EKELLVKESESLQARLSESDYE 2085 Score = 48.1 bits (113), Expect = 5e-05 Identities = 104/510 (20%), Positives = 210/510 (41%), Gaps = 108/510 (21%) Query: 106 VEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKAN 165 V++E M+ + K+ E EK+ E L++ L + + L+T +N+Q ++ Sbjct: 1211 VQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLET--------SNLQD------MQSQ 1256 Query: 166 ENAGLQECPRKGIKFQDADVAETPHPMFTKY--GNSLLEEARGEIRNLENVIQSQRGQIE 223 E +GL++C + D E KY G L ++ + +L+ +Q+ ++ Sbjct: 1257 EISGLKDC--------EIDAEE-------KYISGPHELSTSQNDNAHLQCSLQTTMNKLN 1301 Query: 224 ELEHLAEILKTQLRRKENEIELSLLQ--LREQQATDQRSNIRDNVEMIK-----LHKQLV 276 ELE + EIL+ + E+ S + ++ ++ + + V+++ LH +LV Sbjct: 1302 ELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELV 1361 Query: 277 EKSNALSAMEGKFIQLQEKQRTLRI-------SHDALMANGDELNMQLKEQRLKCCSLE- 328 E G+F + +Q + + S++ L + E+ M E + K SL+ Sbjct: 1362 E-----DIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQS 1416 Query: 329 --KQLHSMKFS-ERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKE--- 382 K LH ++ ELQ ++ L+ E +L N L + E Q L+E Sbjct: 1417 EHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTN---LRNFQGDLVKEMQLGLEEGLV 1473 Query: 383 QQLKVQIAQLETALKS-----------DLTDKTEILDRLKTERDQNEKLVQE--NRELQL 429 L ++L S + T +L L+ N+ V E LQ Sbjct: 1474 PSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQE 1533 Query: 430 QYLEQKQQ-------LDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVK 482 + L +K+ ++EL+ ++Y Q + ++L E + ++Q KN Sbjct: 1534 ENLTRKETPSAPAKGVEELESLCEVYRQ----SLEKLEEKM---ESQGIMKN-------- 1578 Query: 483 VDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQ 542 + ++EL+ + QEL+ R + + N+ +Q ++ +VT +ME+ Sbjct: 1579 ----------KEIQELEQLLSSERQELDCLRKQYLSE---NEQWQQKLTSVTLEMESKLA 1625 Query: 543 DYELKVEQYVHLLDIRAARIHKLEAQLKDI 572 + + EQ L++ ++ L+ + + Sbjct: 1626 AEKKQTEQLSLELEVARLQLQGLDLSSRSL 1655 Score = 46.2 bits (108), Expect = 2e-04 Identities = 99/534 (18%), Positives = 199/534 (37%), Gaps = 94/534 (17%) Query: 117 EKVHELEKQNETLKNRLISAKQQLQT-QGYRQTPYNNVQSRINTGRRKANENAGLQECPR 175 +K+ ELE Q + LK + QL + + Q V++ G EN L E Sbjct: 18 QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLME--- 74 Query: 176 KGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQ 235 + E+ K + E++ E+ + Q GQ+ + E L+ + Sbjct: 75 ---------ICESLEKTKQKISH--------ELQVKESQVNFQEGQLNSGKKQIEKLEQE 117 Query: 236 LRRKENEIELSLLQLREQQATDQRSNIRDNV-----------------EMIKLHKQLVEK 278 L+R ++E+E S + + N + ++ + + + VE+ Sbjct: 118 LKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEE 177 Query: 279 SNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSE 338 L A E K +Q ++ +TL A M + D Q + H S+ Sbjct: 178 RKRLEA-EVKALQAKKASQTL---PQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQ 233 Query: 339 RRIEELQDRINDLEKERELL----------KENYDKLYDSAFSAAHEEQWKLKEQQLKVQ 388 R + E+E+ ++ +D++ S +Q K + Q+L+ + Sbjct: 234 RTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNK 293 Query: 389 IAQLETAL-------KSDLTDKTEI---LDRLKTERDQNEKLVQENRE----LQLQYLEQ 434 I +LE L K + E+ L++ K E + EK++ + R+ QY + Sbjct: 294 INELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQA 353 Query: 435 KQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERS 494 + L++++K ++ A + EQK + + + E ++L R Sbjct: 354 STKYTALEQKLKKLTEDLSCQRQNAESA----RCSLEQK------IKEKEKEFQEELSRQ 403 Query: 495 MRELQATHAETV-------QELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELK 547 R Q E + QEL++ +NM H + ++A K+ +++Q E Sbjct: 404 QRSFQTLDQECIQMKARLTQELQQAKNM----HNV-------LQAELDKLTSVKQQLENN 452 Query: 548 VEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLE 601 +E++ L + + ++ ++ K + ++ S + E HLE Sbjct: 453 LEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLE 506 Score = 40.0 bits (92), Expect = 0.014 Identities = 62/309 (20%), Positives = 126/309 (40%), Gaps = 31/309 (10%) Query: 28 QETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVN 87 +ET R M + +EEL RL E LL + + +D++K + L N Sbjct: 2617 KETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELT-----LEN 2671 Query: 88 DKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQ 147 + + ++ ++ ++ E I + Q ++HE EK+++ L L+ +Q + + Sbjct: 2672 SELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQAL---LLDTNKQYEVE---- 2724 Query: 148 TPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEE-ARG 206 I T R K + I + E + + K +LEE + Sbjct: 2725 ---------IQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSL--KATTQILEELKKT 2773 Query: 207 EIRNLENVIQSQRGQIEELEHLAEILKT--QLRRKENEIELSLLQLREQQATDQRSNIRD 264 ++ NL+ V Q ++ + ++K+ QL ++ ++ L QL+ Q + + D Sbjct: 2774 KMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMD 2833 Query: 265 NVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKC 324 ++ +L ++ E L + + +K +L ISH+ L ++ L+ Q Sbjct: 2834 -TKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKL----EKAKEMLETQVAHL 2888 Query: 325 CSLEKQLHS 333 CS + + S Sbjct: 2889 CSQQSKQDS 2897 >gi|148762940 DVL-binding protein DAPLE [Homo sapiens] Length = 2028 Score = 87.4 bits (215), Expect = 8e-17 Identities = 126/559 (22%), Positives = 244/559 (43%), Gaps = 51/559 (9%) Query: 39 RQAVSRVSREELEDRFLR--LHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVG 96 R+ +RV R ELE + LHD + + +ED I + TK + E++ Sbjct: 319 REKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAML-------EEQLT 371 Query: 97 GGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSR 156 R + E+E+ QL+ K+H+LE +T K R+ ++ Q N + Sbjct: 372 AARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAH 431 Query: 157 INTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQ 216 + + ++NA L + RK F+ + A + K SL +G +R+ V++ Sbjct: 432 LGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQG-LRDASLVLE 490 Query: 217 S---QRGQIEELEH----LAEILKTQLRRKENE------IELSLLQLREQQATDQRSNIR 263 + G++E+ H E L+TQL R++ + L++ +EQ +D + Sbjct: 491 ESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKA 550 Query: 264 DNVEMIKLHKQLVEKSNAL--SAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQR 321 D IK +Q + N S E + + + + + + AL E N +L + Sbjct: 551 DKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLE 610 Query: 322 LKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLK 381 + L + L K R E+L+ + L++E L L A E+ L+ Sbjct: 611 FEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSL-----ETATEKVEALE 665 Query: 382 EQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDEL 441 + +Q+ + T KS LD L+ Q E L ++N++L + LE ++ ++ + Sbjct: 666 HESQGLQL-ENRTLRKS--------LDTLQNVSLQLEGLERDNKQLDAENLELRRLVETM 716 Query: 442 K------KRIKLYNQENDINADELSEALLLIKA-QKEQKNGDLSF--LVKVDSEINKDLE 492 + +++ NQ+ + +EL + + L+KA K+ + +LS+ + + + + LE Sbjct: 717 RFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLE 776 Query: 493 RSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYV 552 S + Q +E + ELE R L + + ++E + + L+Q+ ++E+ Sbjct: 777 SSSHKTQTLESE-LGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEV-AQLEKDK 834 Query: 553 HLLDIRAARIHKLEAQLKD 571 LL+ A R+ + + +LKD Sbjct: 835 KLLEKEAKRLWQ-QVELKD 852 Score = 70.1 bits (170), Expect = 1e-11 Identities = 133/653 (20%), Positives = 270/653 (41%), Gaps = 92/653 (14%) Query: 111 MIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNN-----VQSRINTGRRKAN 165 ++E+ K ELEK+N L ++ ++LQTQ R+ N + I + + Sbjct: 488 VLEESGLKCGELEKENHQLSKKI----EKLQTQLEREKQSNQDLETLSEELIREKEQLQS 543 Query: 166 ENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSL------LEEARGEIRNLENVIQSQR 219 + L+ + IK + + M++ S +++ E + L + Sbjct: 544 DMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEAN 603 Query: 220 GQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKS 279 G++ +LE L L + + + E + RE Q + +N + + L + Sbjct: 604 GKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQE-----ENGRLARKVTSLETAT 658 Query: 280 NALSAMEGKFIQLQEKQRTLRISHDALMANGDEL------NMQLKEQRLKCCSLEKQLHS 333 + A+E + LQ + RTLR S D L +L N QL + L+ L + + + Sbjct: 659 EKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLE---LRRLVET 715 Query: 334 MKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLE 393 M+F+ ++ +++ LE+E+E L++N D L E+ +L Q + + +L+ Sbjct: 716 MRFTSTKLAQMERENQQLEREKEELRKNVDLL---KALGKKSERLELSYQSVSAENLRLQ 772 Query: 394 TALKSDLTDKTEILDRLKTERDQNEKLVQENREL------QLQYLEQ-----KQQLDELK 442 +L+S + KT+ L+ E + + ++ + E QL+ E+ +Q++ +L+ Sbjct: 773 QSLESS-SHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLE 831 Query: 443 KRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVK----VDSEIN---------K 489 K KL +E A L + + L A + LS + K +D E+ K Sbjct: 832 KDKKLLEKE----AKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLK 887 Query: 490 DLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVE 549 +LE+ R+L + L R L+++ ++ E++ +++++E + + EL ++ Sbjct: 888 ELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQ 947 Query: 550 Q--------YVHL-----------LDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDS 590 + Y L L ++ +I LEAQ+++ A +Q + + +++ + Sbjct: 948 EDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKEC 1007 Query: 591 VDEFDETIHLERGE-----NLFEIHINKVTFSSEVLQASG-DKEPVTFCTYAFYDFELQT 644 ET+ +GE N F+ K S + +A G + T D ++ Sbjct: 1008 -----ETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIEL 1062 Query: 645 TPVVRGLHPEYNFTSQYLVHVNDLFLQYIQKNTITLEVHQAYSTEYETIAACQ 697 L E + L H+ + + +TL+ A+ E+ T Q Sbjct: 1063 ERNNAALQAEKQLLKEQLQHLETQNVTF-SSQILTLQKQSAFLQEHNTTLQTQ 1114 Score = 65.1 bits (157), Expect = 4e-10 Identities = 111/566 (19%), Positives = 244/566 (43%), Gaps = 76/566 (13%) Query: 41 AVSRVSREELEDRFLR-----LHDENILLKQHARK---QEDKIKRMATKLIRLVNDKKRY 92 A SR+ + E E++ L+ L D +++L++ K E + +++ K+ +L +R Sbjct: 461 ASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLERE 520 Query: 93 ERVGGGPKRLGRDVEMEEMIEQLQE-----------KVHELEKQNETLKNRLISAKQQLQ 141 ++ + L ++ E+ EQLQ ++ +LE++ + L + S +++ Q Sbjct: 521 KQSNQDLETLSEELIREK--EQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQ 578 Query: 142 TQGY-RQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSL 200 R ++ +AN E ++ + +D + A+ K L Sbjct: 579 VSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLH-RDLEQAKEKGERAEKLEREL 637 Query: 201 --LEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQ---LRRKENEIELSLLQLREQQA 255 L+E G + +++ ++E LEH ++ L+ + LR+ + ++ LQL E Sbjct: 638 QRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQL-EGLE 696 Query: 256 TDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELN- 314 D + +N+E+ +L + + S L+ ME + QL+ ++ LR + D L A G + Sbjct: 697 RDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSER 756 Query: 315 MQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLE---------------------- 352 ++L Q + +L Q S++ S + + L+ + +LE Sbjct: 757 LELSYQSVSAENLRLQ-QSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEG 815 Query: 353 --KERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILD-- 408 K+R+ L++ +L E + ++ +LK + TA S + ++ LD Sbjct: 816 AEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKE 875 Query: 409 --RLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRI---KLYNQENDINADELSEAL 463 R + + ++L ++NR+L Q + L L++ + KL +Q+ D+LS+ L Sbjct: 876 LARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQEL 935 Query: 464 LLIKAQKEQKNGDLSFLVKVDSEINKDLE------RSMRELQATHAETVQELEKTRNMLI 517 + +E L+ + + D + R+ L+ T A +++ + Sbjct: 936 EKVGLNRE--------LLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQME 987 Query: 518 MQHKINKDYQMEVEAVTRKMENLQQD 543 + +N+ + E++ + ++ E L+Q+ Sbjct: 988 EKASLNRQLESELQMLKKECETLRQN 1013 Score = 49.3 bits (116), Expect = 2e-05 Identities = 81/352 (23%), Positives = 157/352 (44%), Gaps = 57/352 (16%) Query: 114 QLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKA----NENAG 169 +++++ ELE+ N L+ K+QLQ + +T S+I T ++++ N Sbjct: 1054 RVKDRAIELERNNAALQAEKQLLKEQLQ---HLETQNVTFSSQILTLQKQSAFLQEHNTT 1110 Query: 170 LQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLA 229 LQ K ++ +++ ++ + +Y L + + EN +S + Q E+L Sbjct: 1111 LQTQTAK-LQVENSTLSSQSAALTAQY---TLLQNHHTAKETEN--ESLQRQQEQLTAAY 1164 Query: 230 EILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKF 289 E L L+ E+ L L E+Q+ + + IR + + LH+ L + L G Sbjct: 1165 EAL---LQDHEH-----LGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDM 1216 Query: 290 I----QLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQ 345 + +L+E+++ L +AL +EQR ++ + +R+ Sbjct: 1217 LKRKAELEEREKVLTTEREALQ----------QEQRTNALAMGEN--------QRLRGEL 1258 Query: 346 DRIN----DLEKERELLKENYDKLYDSAFSAAHE-EQWKLKEQQLKVQIAQLETALKSDL 400 DR+N L+ E E L + +L S +A E +W+ + +LK Q ++ +L + L Sbjct: 1259 DRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISL-TKL 1317 Query: 401 TDKTEILDRLKTERDQN--------EKLVQENRELQLQYLEQKQQLDELKKR 444 + E+L RLK ++ + L Q+N+ L Q +E K+Q E +K+ Sbjct: 1318 DNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQ 1369 Score = 33.9 bits (76), Expect = 0.99 Identities = 37/156 (23%), Positives = 74/156 (47%), Gaps = 18/156 (11%) Query: 202 EEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSN 261 + RGE+ + + +G+ EEL + LKT L ++EL+ Q R + +Q Sbjct: 1252 QRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNA--QLELNRWQARFDELKEQHQT 1309 Query: 262 IRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDEL----NMQL 317 + ++ + H +L LS ++G L+E+ L +S L++ +++ NM+ Sbjct: 1310 MDISLTKLDNHCEL------LSRLKG---NLEEENHHL-LSQIQLLSQQNQMLLEQNMEN 1359 Query: 318 KEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEK 353 KEQ + ++ + + R E+L+++I D K Sbjct: 1360 KEQYHE--EQKQYIDKLNALRRHKEKLEEKIMDQYK 1393 >gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sapiens] Length = 1843 Score = 86.3 bits (212), Expect = 2e-16 Identities = 130/588 (22%), Positives = 261/588 (44%), Gaps = 84/588 (14%) Query: 48 EELEDRFLRLHDENILLKQHARKQE------DKIKRMATKLIRLVNDKKRY-------ER 94 E++E RL EN+ L AR D ++ A ++ +L ++ RY E Sbjct: 282 EQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEF 341 Query: 95 VGGGPKRLGRD----VEMEEMIE-QLQ------EKVHELEKQNETLKNRLISAK------ 137 + L D +E + M+E QL+ +K+HELEK+N LK +L + Sbjct: 342 YKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMD 401 Query: 138 --------QQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETP 189 ++ T Q + + + + + L E P+K + + ++ + Sbjct: 402 RKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSS- 460 Query: 190 HPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEI--ELSL 247 + + N L + E+R + ++ +I ++E + L ++ ENEI E Sbjct: 461 RLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQS 520 Query: 248 LQ--------LREQQATDQRS--NIRDNVE-MIKLHKQLVEKSN--ALSAMEGKFIQLQE 294 LQ L +++A +++ +R+N E IK+ +Q E N S + I + Sbjct: 521 LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA 580 Query: 295 KQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKE 354 + + + + L + E + +L + + ++K+L K R EEL++ ++ LEKE Sbjct: 581 RVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKE 640 Query: 355 RELLKENYD--KLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKT 412 ELL++ K+ A +E +L+ + K++ + LD K Sbjct: 641 NELLQKKITNLKITCEKIEALEQENSELERENRKLK----------------KTLDSFKN 684 Query: 413 ERDQNEKLVQENRELQLQYLEQKQQLDELK------KRIKLYNQENDINADELSEALLLI 466 Q E L +EN +L + LE ++ ++ LK +++L N+E + ++L + L L+ Sbjct: 685 LTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL 744 Query: 467 KAQ-KEQKNGDLSF--LVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKIN 523 KA K+ + ++S+ L + + K LE S +++Q +E +Q+LE L + Sbjct: 745 KASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESE-LQDLEMENQTLQKNLEEL 803 Query: 524 KDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKD 571 K +E + ++ ++L+Q+ ++E+ L+ R+ + +A++KD Sbjct: 804 KISSKRLEQLEKENKSLEQETS-QLEKDKKQLEKENKRLRQ-QAEIKD 849 Score = 81.3 bits (199), Expect = 5e-15 Identities = 114/520 (21%), Positives = 229/520 (44%), Gaps = 86/520 (16%) Query: 34 RTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYE 93 +T+ S + S++S E R + EN +L + IK ++KL ++ +K++ + Sbjct: 565 QTVSSLRQRSQISAEA---RVKDIEKENKIL-------HESIKETSSKLSKIEFEKRQIK 614 Query: 94 RVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNV 153 K L E E E+L+ ++H LEK+NE L+ ++ N+ Sbjct: 615 ------KELEHYKEKGERAEELENELHHLEKENELLQKKI-----------------TNL 651 Query: 154 QSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLEN 213 + EN+ L+ RK K D+ T + NS L+E E+R Sbjct: 652 KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRR--- 708 Query: 214 VIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHK 273 +E L K ++++ LQL ++ ++ ++ +E++K Sbjct: 709 -------NVESL-------------KCASMKMAQLQLENKELESEKEQLKKGLELLKASF 748 Query: 274 QLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHS 333 + E+ + +G I+ Q Q+TL S+ + +L +L++ ++ +L+K L Sbjct: 749 KKTERLEV--SYQGLDIENQRLQKTLENSNKKIQ----QLESELQDLEMENQTLQKNLEE 802 Query: 334 MKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLK---VQIA 390 +K S +R+E+L+ LE+E L++ DK + +Q ++K+ L+ V+I Sbjct: 803 LKISSKRLEQLEKENKSLEQETSQLEK--DKKQLEKENKRLRQQAEIKDTTLEENNVKIG 860 Query: 391 QLE---TALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKL 447 LE L ++ E RLK +N++LV + + ++ L ++ D + +++K Sbjct: 861 NLEKENKTLSKEIGIYKESCVRLKELEKENKELV-KRATIDIKTLVTLRE-DLVSEKLKT 918 Query: 448 YNQENDINADELSEALLLIKAQKE-----QKNGDLSFLVKVDSEINKDLERSMRELQATH 502 ND+ ++L+ L I KE +++ D S ++S++ L++S+ + Sbjct: 919 QQMNNDL--EKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKI 976 Query: 503 AETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQ 542 A LE++ N N+ + E++ V + E L+Q Sbjct: 977 AALEARLEESTN-------YNQQLRQELKTVKKNYEALKQ 1009 Score = 73.9 bits (180), Expect = 9e-13 Identities = 130/638 (20%), Positives = 254/638 (39%), Gaps = 105/638 (16%) Query: 27 LQETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQ-EDKIKRMATKLIRL 85 LQ+T K +Q S + E+E++ L+ + E + + +Q E + K + + +L Sbjct: 768 LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQL 827 Query: 86 VNDKKRYERVGGGPKRLGRDVEMEEM-IEQLQEKVHELEKQNETLKNR------------ 132 DKK+ E+ KRL + E+++ +E+ K+ LEK+N+TL Sbjct: 828 EKDKKQLEKEN---KRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK 884 Query: 133 -------------------LISAKQQLQTQGYRQTPYNNVQSRINTGRRKANEN------ 167 L++ ++ L ++ + NN ++ K N Sbjct: 885 ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLH 944 Query: 168 --------------AGLQECPRKGIKFQDADVA--ETPHPMFTKYGNSLLEEARGEIRNL 211 + L+ +K ++ ++ +A E T Y L +E + +N Sbjct: 945 DEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNY 1004 Query: 212 ENVIQSQRGQIEELEHLAEILK---TQLRRKENEIELSLLQLREQQATDQRSNIRDNVEM 268 E + QR E + + + + R+ E LL+++++ +R+N E Sbjct: 1005 EAL--KQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK 1062 Query: 269 IKLH---KQLVEKSNALSA----MEGKFIQLQEKQRTLRISHDALMANGDELNMQ---LK 318 L KQL ++N L A ++ + + LQE+ TL+ + L LN Q L Sbjct: 1063 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM 1122 Query: 319 EQR----LKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAH 374 Q ++ SLE + S+ ++ L D + ++ ELL E Y+S S Sbjct: 1123 NQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLIS--K 1180 Query: 375 EEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQ 434 K + L+V+ LE L K ++ D K + + EK++ EN+ + E Sbjct: 1181 HGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEY 1240 Query: 435 KQQLDELKKRIKLYNQ---ENDI-NADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKD 490 K+ E + Y+Q E ++ D + LL ++ EQ ++++E +K Sbjct: 1241 KKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQ--------TRLEAEFSK- 1291 Query: 491 LERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQD------- 543 L+ ++L T + + E + + N+ +++ + + L + Sbjct: 1292 LKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDL 1351 Query: 544 YELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKF 581 + ++ QY+ L+ + KLE ++ D QYKF Sbjct: 1352 FHVEQRQYIDKLNELRRQKEKLEEKIMD------QYKF 1383 Score = 64.3 bits (155), Expect = 7e-10 Identities = 116/518 (22%), Positives = 224/518 (43%), Gaps = 77/518 (14%) Query: 107 EMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANE 166 E+EE EQL + ELE+ LK RL L + Y + ++ R KA Sbjct: 266 ELEEKTEQLLDCKQELEQMEIELK-RLQQENMNLLSDARSARMY---RDELDALREKAVR 321 Query: 167 NAGLQ-ECPR-----KGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRG 220 L+ E R I+F A V E K N +L E + + + +++ Sbjct: 322 VDKLESEVSRYKERLHDIEFYKARVEE------LKEDNQVLLETKTMLEDQLEGTRARSD 375 Query: 221 QIEELE----------HLAEILKTQLRRKENEI--ELSLLQLREQQATDQRSNIRDNVEM 268 ++ ELE H E+ + R+K E+ E L++ ++Q+ D+ ++ +E Sbjct: 376 KLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQ 435 Query: 269 IKLHKQLVE-------------KSNALSAMEGKFIQLQEKQRTLRISHDALMANGDE-LN 314 I +L E S+ L +E + L + LR + D++ N + L Sbjct: 436 ISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILK 495 Query: 315 MQLKEQRL--KCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSA 372 M+ + QRL K LE ++ K S ++ Q+ DL KE+ L++ + L +++ Sbjct: 496 MEKENQRLSKKVEILENEIVQEKQS---LQNCQNLSKDLMKEKAQLEKTIETLRENS--- 549 Query: 373 AHEEQWKLKEQQ---LKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQL 429 E Q K+ EQ+ L ++ L +S ++ + + D K + +E + + + +L Sbjct: 550 --ERQIKILEQENEHLNQTVSSLRQ--RSQISAEARVKDIEKENKILHESIKETSSKLSK 605 Query: 430 QYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINK 489 E++Q +KK ++ Y ++ + A+EL L ++ + E ++ L K+ E + Sbjct: 606 IEFEKRQ----IKKELEHYKEKGE-RAEELENELHHLEKENELLQKKITNL-KITCEKIE 659 Query: 490 DLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYE-LKV 548 LE+ EL+ + + + L+ +N+ + K EN Q D E L++ Sbjct: 660 ALEQENSELERENRKLKKTLDSFKNLTFQLESLEK-------------ENSQLDEENLEL 706 Query: 549 EQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIM 586 + V L + ++ +L+ + K++ +Q K E++ Sbjct: 707 RRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL 744 Score = 33.5 bits (75), Expect = 1.3 Identities = 30/139 (21%), Positives = 74/139 (53%), Gaps = 4/139 (2%) Query: 419 KLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLS 478 +L QE E Q L+ KQ+L++++ +K QEN +N + + + + + + Sbjct: 262 RLRQELEEKTEQLLDCKQELEQMEIELKRLQQEN-MNLLSDARSARMYRDELDALREKAV 320 Query: 479 FLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKME 538 + K++SE+++ ER + +++ A V+EL++ +L+ + +D A + K+ Sbjct: 321 RVDKLESEVSRYKER-LHDIEFYKAR-VEELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378 Query: 539 NLQQDYELKVEQYVHLLDI 557 L+++ L+++ +H +++ Sbjct: 379 ELEKE-NLQLKAKLHDMEM 396 >gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo sapiens] Length = 1870 Score = 86.3 bits (212), Expect = 2e-16 Identities = 130/588 (22%), Positives = 261/588 (44%), Gaps = 84/588 (14%) Query: 48 EELEDRFLRLHDENILLKQHARKQE------DKIKRMATKLIRLVNDKKRY-------ER 94 E++E RL EN+ L AR D ++ A ++ +L ++ RY E Sbjct: 282 EQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEF 341 Query: 95 VGGGPKRLGRD----VEMEEMIE-QLQ------EKVHELEKQNETLKNRLISAK------ 137 + L D +E + M+E QL+ +K+HELEK+N LK +L + Sbjct: 342 YKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMD 401 Query: 138 --------QQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETP 189 ++ T Q + + + + + L E P+K + + ++ + Sbjct: 402 RKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSS- 460 Query: 190 HPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEI--ELSL 247 + + N L + E+R + ++ +I ++E + L ++ ENEI E Sbjct: 461 RLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQS 520 Query: 248 LQ--------LREQQATDQRS--NIRDNVE-MIKLHKQLVEKSN--ALSAMEGKFIQLQE 294 LQ L +++A +++ +R+N E IK+ +Q E N S + I + Sbjct: 521 LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA 580 Query: 295 KQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKE 354 + + + + L + E + +L + + ++K+L K R EEL++ ++ LEKE Sbjct: 581 RVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKE 640 Query: 355 RELLKENYD--KLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKT 412 ELL++ K+ A +E +L+ + K++ + LD K Sbjct: 641 NELLQKKITNLKITCEKIEALEQENSELERENRKLK----------------KTLDSFKN 684 Query: 413 ERDQNEKLVQENRELQLQYLEQKQQLDELK------KRIKLYNQENDINADELSEALLLI 466 Q E L +EN +L + LE ++ ++ LK +++L N+E + ++L + L L+ Sbjct: 685 LTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL 744 Query: 467 KAQ-KEQKNGDLSF--LVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKIN 523 KA K+ + ++S+ L + + K LE S +++Q +E +Q+LE L + Sbjct: 745 KASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESE-LQDLEMENQTLQKNLEEL 803 Query: 524 KDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKD 571 K +E + ++ ++L+Q+ ++E+ L+ R+ + +A++KD Sbjct: 804 KISSKRLEQLEKENKSLEQETS-QLEKDKKQLEKENKRLRQ-QAEIKD 849 Score = 80.1 bits (196), Expect = 1e-14 Identities = 118/523 (22%), Positives = 228/523 (43%), Gaps = 93/523 (17%) Query: 34 RTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYE 93 +T+ S + S++S E R + EN +L + IK ++KL ++ +K++ + Sbjct: 565 QTVSSLRQRSQISAEA---RVKDIEKENKIL-------HESIKETSSKLSKIEFEKRQIK 614 Query: 94 RVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNV 153 K L E E E+L+ ++H LEK+NE L+ ++ N+ Sbjct: 615 ------KELEHYKEKGERAEELENELHHLEKENELLQKKI-----------------TNL 651 Query: 154 QSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLEN 213 + EN+ L+ RK K D+ T + NS L+E E+R Sbjct: 652 KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRR--- 708 Query: 214 VIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHK 273 +E L K ++++ LQL ++ ++ ++ +E++K Sbjct: 709 -------NVESL-------------KCASMKMAQLQLENKELESEKEQLKKGLELLKASF 748 Query: 274 QLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHS 333 + E+ + +G I+ Q Q+TL S+ + +L +L++ ++ +L+K L Sbjct: 749 KKTERLEV--SYQGLDIENQRLQKTLENSNKKIQ----QLESELQDLEMENQTLQKNLEE 802 Query: 334 MKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLK---VQIA 390 +K S +R+E+L+ LE+E L++ DK + +Q ++K+ L+ V+I Sbjct: 803 LKISSKRLEQLEKENKSLEQETSQLEK--DKKQLEKENKRLRQQAEIKDTTLEENNVKIG 860 Query: 391 QLE---TALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKL 447 LE L ++ E RLK +N++LV + + ++ L ++ D + +++K Sbjct: 861 NLEKENKTLSKEIGIYKESCVRLKELEKENKELV-KRATIDIKTLVTLRE-DLVSEKLKT 918 Query: 448 YNQENDINADELSEALLLIKAQK------EQKNGDLSFLV--KVDSEINKDLERSMRELQ 499 ND+ ++L+ L I K EQ D L+ K++S + K LE ++ Sbjct: 919 QQMNNDL--EKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIA 976 Query: 500 ATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQ 542 A A LE++ N N+ + E++ V + E L+Q Sbjct: 977 ALEA----RLEESTN-------YNQQLRQELKTVKKNYEALKQ 1008 Score = 69.3 bits (168), Expect = 2e-11 Identities = 108/502 (21%), Positives = 222/502 (44%), Gaps = 72/502 (14%) Query: 27 LQETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQH---------ARKQEDKIKR 77 L E+ T+K + LE R + N L+Q A KQ +R Sbjct: 955 LLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEER 1014 Query: 78 MATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAK 137 M + + ++ER E + ++++++ E+E+ N TL+ + K Sbjct: 1015 MVQSSPPISGEDNKWER---------ESQETTRELLKVKDRLIEVERNNATLQ----AEK 1061 Query: 138 QQLQTQGYR-QTPYNNVQSRINTGRRKA----NENAGLQECPRKGIKFQDADVAETPHPM 192 Q L+TQ + +T NN+Q++I +R+ +N LQ K ++ +++ + + Sbjct: 1062 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAK-LQVENSTLNSQSTSL 1120 Query: 193 FTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLRE 252 + L++++ +LEN +S + E+L+ L + L + ++EL L E Sbjct: 1121 MNQNAQLLIQQS-----SLENENESVIKEREDLKSLYD----SLIKDHEKLEL----LHE 1167 Query: 253 QQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFI----QLQEKQRTLRISHDALMA 308 +QA++ S I + + HK L + L + + QL++ ++ L++ + ++ Sbjct: 1168 RQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLL 1227 Query: 309 NGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDS 368 E + C ++ H+ + E LQ D + + LL N KL + Sbjct: 1228 ENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQ---TDHKNLKSLL--NNSKLEQT 1282 Query: 369 AFSAAHEEQWKLKEQQLKVQIA--------QLETALKSDLTDKTE-ILDRLKTERDQNEK 419 A E KLKEQ ++ I +L + LK +L ++ +LD+++T QN Sbjct: 1283 RLEA---EFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRT 1339 Query: 420 LVQENRELQ-LQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGD-- 476 L+++N E + L ++EQ+Q +D+L +L Q+ + +++ + ++ G+ Sbjct: 1340 LLEQNMESKDLFHVEQRQYIDKLN---ELRRQKEKLE-EKIMDQYKFYDPSPPRRRGNWI 1395 Query: 477 ---LSFLVKVDSEINKDLERSM 495 + L+K +IN++ ++S+ Sbjct: 1396 TLKMRKLIKSKKDINRERQKSL 1417 Score = 64.3 bits (155), Expect = 7e-10 Identities = 116/518 (22%), Positives = 224/518 (43%), Gaps = 77/518 (14%) Query: 107 EMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANE 166 E+EE EQL + ELE+ LK RL L + Y + ++ R KA Sbjct: 266 ELEEKTEQLLDCKQELEQMEIELK-RLQQENMNLLSDARSARMY---RDELDALREKAVR 321 Query: 167 NAGLQ-ECPR-----KGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRG 220 L+ E R I+F A V E K N +L E + + + +++ Sbjct: 322 VDKLESEVSRYKERLHDIEFYKARVEE------LKEDNQVLLETKTMLEDQLEGTRARSD 375 Query: 221 QIEELE----------HLAEILKTQLRRKENEI--ELSLLQLREQQATDQRSNIRDNVEM 268 ++ ELE H E+ + R+K E+ E L++ ++Q+ D+ ++ +E Sbjct: 376 KLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQ 435 Query: 269 IKLHKQLVE-------------KSNALSAMEGKFIQLQEKQRTLRISHDALMANGDE-LN 314 I +L E S+ L +E + L + LR + D++ N + L Sbjct: 436 ISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILK 495 Query: 315 MQLKEQRL--KCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSA 372 M+ + QRL K LE ++ K S ++ Q+ DL KE+ L++ + L +++ Sbjct: 496 MEKENQRLSKKVEILENEIVQEKQS---LQNCQNLSKDLMKEKAQLEKTIETLRENS--- 549 Query: 373 AHEEQWKLKEQQ---LKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQL 429 E Q K+ EQ+ L ++ L +S ++ + + D K + +E + + + +L Sbjct: 550 --ERQIKILEQENEHLNQTVSSLRQ--RSQISAEARVKDIEKENKILHESIKETSSKLSK 605 Query: 430 QYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINK 489 E++Q +KK ++ Y ++ + A+EL L ++ + E ++ L K+ E + Sbjct: 606 IEFEKRQ----IKKELEHYKEKGE-RAEELENELHHLEKENELLQKKITNL-KITCEKIE 659 Query: 490 DLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYE-LKV 548 LE+ EL+ + + + L+ +N+ + K EN Q D E L++ Sbjct: 660 ALEQENSELERENRKLKKTLDSFKNLTFQLESLEK-------------ENSQLDEENLEL 706 Query: 549 EQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIM 586 + V L + ++ +L+ + K++ +Q K E++ Sbjct: 707 RRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL 744 Score = 62.8 bits (151), Expect = 2e-09 Identities = 121/602 (20%), Positives = 252/602 (41%), Gaps = 111/602 (18%) Query: 27 LQETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQ-EDKIKRMATKLIRL 85 LQ+T K +Q S + E+E++ L+ + E + + +Q E + K + + +L Sbjct: 768 LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQL 827 Query: 86 VNDKKRYERVGGGPKRLGRDVEMEEM-IEQLQEKVHELEKQNETLKNRLISAKQQLQTQG 144 DKK+ E+ KRL + E+++ +E+ K+ LEK+N+TL + K+ Sbjct: 828 EKDKKQLEKEN---KRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCV--- 881 Query: 145 YRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEA 204 R K E + R I + L Sbjct: 882 ----------------RLKELEKENKELVKRATIDIKT------------------LVTL 907 Query: 205 RGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRD 264 R ++ + + Q +E+L H E+ K L ++ L ++Q+TD R + + Sbjct: 908 REDLVSEKLKTQQMNNDLEKLTH--ELEKIGLNKER--------LLHDEQSTDDRYKLLE 957 Query: 265 NVEMIKLHKQLVEKSNALSAMEGKF-------IQLQEKQRTLRISHDALMANGDELNM-- 315 + L K L K ++A+E + QL+++ +T++ +++AL DE M Sbjct: 958 SKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQ 1017 Query: 316 -----QLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLK------ENYDK 364 ++ + + S E +K +R IE ++ L+ E++ LK E + Sbjct: 1018 SSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT-LQAEKQALKTQLKQLETQNN 1076 Query: 365 LYDSAFSAAHEEQWKLKEQ---------QLKVQIAQLETALKSDLTDKTEILDRLKTERD 415 + A + L+EQ +L+V+ + L + S + ++L + + + Sbjct: 1077 NLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLEN 1136 Query: 416 QNEKLVQENRELQLQY---LEQKQQLDELKKR--------------IKLYNQENDINADE 458 +NE +++E +L+ Y ++ ++L+ L +R +K ++ ++ + Sbjct: 1137 ENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRD 1196 Query: 459 LSEALLLIKAQKEQKNGDLSFLVKVDSE----INKDLERSMRELQATHAETVQELEKTRN 514 L + + QK Q DL ++KV+ E NK+ E E + E L T + Sbjct: 1197 LEDRYNQLLKQKGQLE-DLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEN-DRLNHTYS 1254 Query: 515 MLIMQHKINKDYQMEVEAV--TRKMENLQQDYEL-KVEQYVHLLDIRAARIH---KLEAQ 568 L+ + ++ + ++++ K+E + + E K+++ LDI + +++ +L +Q Sbjct: 1255 QLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQ 1314 Query: 569 LK 570 LK Sbjct: 1315 LK 1316 Score = 33.5 bits (75), Expect = 1.3 Identities = 30/139 (21%), Positives = 74/139 (53%), Gaps = 4/139 (2%) Query: 419 KLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLS 478 +L QE E Q L+ KQ+L++++ +K QEN +N + + + + + + Sbjct: 262 RLRQELEEKTEQLLDCKQELEQMEIELKRLQQEN-MNLLSDARSARMYRDELDALREKAV 320 Query: 479 FLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKME 538 + K++SE+++ ER + +++ A V+EL++ +L+ + +D A + K+ Sbjct: 321 RVDKLESEVSRYKER-LHDIEFYKAR-VEELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378 Query: 539 NLQQDYELKVEQYVHLLDI 557 L+++ L+++ +H +++ Sbjct: 379 ELEKE-NLQLKAKLHDMEM 396 >gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with transmembrane signal), 1 [Homo sapiens] Length = 3259 Score = 85.9 bits (211), Expect = 2e-16 Identities = 142/657 (21%), Positives = 265/657 (40%), Gaps = 121/657 (18%) Query: 34 RTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYE 93 RT+K+ + V S+++LE + EN+ RK+ +A+ + L + + Sbjct: 2040 RTVKALEFVQTESQKDLE-----ITKENLAQAVEHRKKAQA--ELASFKVLLDDTQSEAA 2092 Query: 94 RVGGGPKRLGRDVEM--EEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQ-------- 143 RV +L ++++ E + Q+++K +LE++ E + + + K+ +Q + Sbjct: 2093 RVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREK 2152 Query: 144 GYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSL--- 200 + + +Q +N +K E LQE + D T FTK +SL Sbjct: 2153 VHLEETIGEIQVTLN---KKDKEVQQLQE---------NLDSTVTQLAAFTKSMSSLQDD 2200 Query: 201 ----LEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQAT 256 ++EA+ R + IQS+ +I E +LK QLR+ +E Sbjct: 2201 RDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHME------------ 2248 Query: 257 DQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQ 316 ++ N+ ++ KQ+ E +QLQ+K D L EL Q Sbjct: 2249 ----ELKINISRLEHDKQIWESKAQTE------VQLQQK------VCDTLQGENKELLSQ 2292 Query: 317 LKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEE 376 L+E R S + +L + E ++ L+D++ DL E KE L Sbjct: 2293 LEETRHLYHSSQNELAKL---ESELKSLKDQLTDLSNSLEKCKEQKGNL----------- 2338 Query: 377 QWKLKEQQLKVQIAQLE-TALKSDLTDKTEILDRLKTERDQNEK-----LVQENRELQLQ 430 + +++Q+ +Q ++ L++DL E+ RL E + E+ L + +Q+ Sbjct: 2339 EGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVA 2398 Query: 431 YLEQKQQLD-ELKKRIKLYNQENDIN-------------ADELSEALLLIKAQKEQKNGD 476 E +QQ D E+K+ L +QE + N ++L E L IK + Q+ Sbjct: 2399 IAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQ 2458 Query: 477 LSFLVKVDSEINKDLER---SMRELQATHA-------ETVQELEKTRNMLIMQHKINKDY 526 L VK S + D +R ++L+ H + +QE N L + + + + Sbjct: 2459 LDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSH 2518 Query: 527 QMEVEAVTRKM--------ENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQ 578 ++ + K+ E+L Q +K Q LL+++ + +LE + Y + Sbjct: 2519 MDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENK-----YAKLE 2573 Query: 579 YKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTY 635 K K ++ + + E+ + EI KV+ S Q + +E T Y Sbjct: 2574 EKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLY 2630 Score = 73.6 bits (179), Expect = 1e-12 Identities = 123/562 (21%), Positives = 236/562 (41%), Gaps = 61/562 (10%) Query: 55 LRLHDENI-LLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDV------E 107 +RL ++N +LK R+ ++ + + RL +DK+ +E +L + V E Sbjct: 2226 IRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGE 2285 Query: 108 MEEMIEQLQEKVHELEK-QNET--LKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKA 164 +E++ QL+E H QNE L++ L S K QL T +N + + Sbjct: 2286 NKELLSQLEETRHLYHSSQNELAKLESELKSLKDQL-------TDLSNSLEKCKEQKGNL 2338 Query: 165 NENAGLQECPRKGIKFQ----------DADVAETPHPMFTKYGNSLLEEARGEIRNLENV 214 QE + KF ++ H ++ G+ ++ Sbjct: 2339 EGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVA 2398 Query: 215 IQSQRGQ----IEELEHLA--EILKTQLRRKENEIELSLL-QLREQQATDQRSNIRDNVE 267 I R Q I+ELE+L E + + +EN+ + QL E T ++ NI+ + Sbjct: 2399 IAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQ 2458 Query: 268 MIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSL 327 + K + N + G + QL+E+ ++ + D L+ N +LKE+ S Sbjct: 2459 LDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSH 2518 Query: 328 EKQLHS--MKFSERRIEELQD-----RINDLEKEREL-LKENYDKLYDSAFSAAHEEQWK 379 L+S K I+ +D I D ++++ L ++ +K ++ ++ E K Sbjct: 2519 MDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEE---K 2575 Query: 380 LKE-QQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLV---QENRELQLQYLEQK 435 LKE ++ + + AL+ + D ++ ++ LK Q + V QE L L + + K Sbjct: 2576 LKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLK 2635 Query: 436 QQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVD-SEINKDLERS 494 + +E+ + L++ A EL E L+ ++ + +K G++ +K + ++ D Sbjct: 2636 VKEEEVHRLSALFSSSQKRIA-ELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIM 2694 Query: 495 MRELQATH---AETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQY 551 E + AE ++L + L+M K NK ++++ R M +LQ + E+ Sbjct: 2695 RNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEEL 2754 Query: 552 VHLLDIRAARIHKLEAQLKDIA 573 L K +A LK++A Sbjct: 2755 DELK-------RKYDASLKELA 2769 Score = 70.5 bits (171), Expect = 1e-11 Identities = 134/627 (21%), Positives = 266/627 (42%), Gaps = 94/627 (14%) Query: 73 DKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHE----------- 121 ++I K+I L++ K+ +V R D E++E+ L ++ E Sbjct: 2375 EEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKA 2434 Query: 122 LEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQ 181 ++K N+ ++ K+ +Q + + ++ S N R + L+E I + Sbjct: 2435 VDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEK 2494 Query: 182 DADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIE-ELEHLAEILKTQLRRKE 240 D + E N L EE RG +R+ + + S+ +++ EL E L + K+ Sbjct: 2495 DQLIQEA-----AAENNKLKEEIRG-LRSHMDDLNSENAKLDAELIQYREDLNQVITIKD 2548 Query: 241 NEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLR 300 ++ + LL+++ QQ + + + KL ++L E A + F LQE+++ L Sbjct: 2549 SQ-QKQLLEVQLQQNKELEN------KYAKLEEKLKESEEANEDLRRSFNALQEEKQDLS 2601 Query: 301 ISHDALMANGDELNMQ-----------LKEQRLKCCSLEKQLHSMKFS--ERRIEELQDR 347 ++L + +L Q L +LK E S FS ++RI EL++ Sbjct: 2602 KEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEE 2661 Query: 348 INDLEKER---------ELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETAL-- 396 + ++KE +L KE +D+ E + + +L + ++E L Sbjct: 2662 LVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLM 2721 Query: 397 ----KSDLTDKTEILDR-LKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQE 451 LT + + R + + ++ + +E EL+ +Y ++L +LK++ L N+E Sbjct: 2722 VTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQ-GLLNRE 2780 Query: 452 NDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEI----------NKDLERSMRELQAT 501 D LSE + + +E LS L K++ ++ + LE S ++Q+ Sbjct: 2781 RDAL---LSETAFSMNSTEENS---LSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQS- 2833 Query: 502 HAETVQELEKTRNMLIMQ-HKINKDYQ-------------MEVEAVTRKMENLQQDY--- 544 ++ + L+ R+ L + K K + EV+++ + M +LQ D Sbjct: 2834 FSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRL 2893 Query: 545 --ELKVEQYVHL-LDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLE 601 ELK Q +L ++ +H L+AQL++ TK ++ E + +++ E L Sbjct: 2894 LKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLR 2953 Query: 602 RGENLFEIHINKVTFSSEVLQASGDKE 628 ++ +EIH ++ + L A DK+ Sbjct: 2954 MEKSSWEIHERRM--KEQYLMAISDKD 2978 Score = 66.2 bits (160), Expect = 2e-10 Identities = 120/573 (20%), Positives = 227/573 (39%), Gaps = 78/573 (13%) Query: 27 LQETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKR-MATKLIRL 85 LQE + M+ + R + + + L L +EN L+ D K M T L Sbjct: 1664 LQEAE--QEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSN 1721 Query: 86 VNDKKRYERVGGGPKRLGRDV-----EMEEMIEQLQEKVHELEKQNETLKNRLISAKQQL 140 + K+ ERV + L + E + + E++Q+ H++E N + K Sbjct: 1722 ASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDN 1781 Query: 141 QT----QGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKY 196 QT +G + P G + ++ + P + A++ +P +K Sbjct: 1782 QTNVTEEGTQSIP----------GETEEQDSLSMSTRPTCS---ESVPSAKSANPAVSKD 1828 Query: 197 GNS---------LLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEI---- 243 +S +++ + I LE Q + + LE+ L +Q+ K+ E+ Sbjct: 1829 FSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQ 1888 Query: 244 -ELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKS--NALSAMEGKFIQLQEKQRTLR 300 E++ + L QQ ++ S + E + K +E+ N L+ + G + + Sbjct: 1889 EEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQ 1948 Query: 301 ISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKE 360 I ++ L + L KC S ++ E+ E + R LEK + KE Sbjct: 1949 IKNELLESEMKNLK--------KCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKE 2000 Query: 361 NYDKLYDSAFSAAHEEQWKLKEQQLKVQ------------IAQLETALKSDLTDKTEILD 408 +K S A E Q LKE+Q +V+ I+ LE +K+ +TE Sbjct: 2001 PGNK------SHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQK 2054 Query: 409 RLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKA 468 L+ ++ + V+ ++ Q + K LD+ + +N EL +K+ Sbjct: 2055 DLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKS 2114 Query: 469 QKEQKNGDLSFLVKVDSEINKDLERSMRE-LQATHAETVQELEKTRNMLIMQHKINKDYQ 527 Q +QK+ DL ++ E + +++M+E L A E V E + + +K +K+ Q Sbjct: 2115 QMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQ 2174 Query: 528 M----------EVEAVTRKMENLQQDYELKVEQ 550 ++ A T+ M +LQ D + +++ Sbjct: 2175 QLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDE 2207 Score = 65.5 bits (158), Expect = 3e-10 Identities = 121/527 (22%), Positives = 221/527 (41%), Gaps = 81/527 (15%) Query: 106 VEMEEMIEQ----LQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGR 161 VE++++I Q LQ+K L+++ + N++ K + + T N + Sbjct: 62 VELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKA---KLTSLNKYIEEM---- 114 Query: 162 RKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLE-NVIQSQRG 220 KA L P+ + D + T M + L+E I L+ + Q+Q Sbjct: 115 -KAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAE 173 Query: 221 Q----IEELEHLAEILKTQLRRKE---NEIELSLLQLREQQATDQRSNIRDN--VEMIKL 271 Q E+E ++K QL+ KE + ++ L Q + +QA Q +D ++L Sbjct: 174 QPAQSSTEMEEFV-MMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRL 232 Query: 272 HK----QLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSL 327 H+ QLV +++ + M+ K L+ QR L ++L+ ++ L +Q L Sbjct: 233 HEDELLQLVTQADVETEMQQK---LRVLQRKLEEHEESLVGRAQVVD--LLQQELTAAEQ 287 Query: 328 EKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLY------DSAFSAAHEEQWKLK 381 Q+ S + + E R N +E ERE K +K+ +F EE L Sbjct: 288 RNQILSQQLQQMEAEHNTLR-NTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLL 346 Query: 382 EQ---------QLKVQIAQLETALKSDLTDKTE-ILDRLKTE----------RDQNEKLV 421 EQ +L+ + + LE K+++ +KT IL KT +DQN KL+ Sbjct: 347 EQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLL 406 Query: 422 QENRELQLQYLEQKQQL-DELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFL 480 Q+ E +Q + QQL D+L+++ K E+S+ L + Q+ + SF Sbjct: 407 QDKNEQAVQSAQTIQQLEDQLQQKSK-----------EISQFLNRLPLQQHETASQTSF- 454 Query: 481 VKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKM--- 537 N+ + E A+ + V ELE + L++ ++ + E E ++ ++ Sbjct: 455 ---PDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLL 511 Query: 538 --ENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFK 582 +N + + +V + + ++DI R E +D+ T K K Sbjct: 512 EAQNRTGEADREVSE-ISIVDIANKRSSSAEESGQDVLENTFSQKHK 557 Score = 61.6 bits (148), Expect = 4e-09 Identities = 89/391 (22%), Positives = 171/391 (43%), Gaps = 45/391 (11%) Query: 198 NSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILK-----TQLRRKENEIELSLLQLRE 252 N L+EE + +N +N + EE + L +K T+LR + ++E++L + Sbjct: 722 NQLIEEFK---KNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAER 778 Query: 253 QQATDQRSNI-RDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGD 311 Q+ D S DN+ L E+ ++LS ++ K + ++I + L D Sbjct: 779 QRRLDYESQTAHDNL--------LTEQIHSLS--------IEAKSKDVKI--EVLQNELD 820 Query: 312 ELNMQLKEQRLKCCSLEKQLHSMKFSE-----RRIEELQDRINDL-----EKERELLKEN 361 ++ +Q EQ SL+ QL + K SE R+ + ++ +L +KE E+ K + Sbjct: 821 DVQLQFSEQSTLIRSLQSQLQN-KESEVLEGAERVRHISSKVEELSQALSQKELEITKMD 879 Query: 362 YDKLYDSAFSAAHEEQWKLKEQQL-KVQIAQLETALKSDLTDKTEILDRLKTERDQNEKL 420 L ++ + K+QQ+ ++ + E ++ + +K + +KT ++Q L Sbjct: 880 QLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLN-EEKFSLGVEIKTLKEQLNLL 938 Query: 421 VQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFL 480 + + Q E + LK+ + I+ +EL L+K + EQ+ L Sbjct: 939 SRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAA 998 Query: 481 VKVDSEINKDLERSMRELQATHAETVQE--LEKTRNMLIMQHKINKDYQMEVEAVTRKME 538 + E+ + + R EL E+ +E L +T + + K NK+Y + VT K + Sbjct: 999 LINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEY--SEKCVTSKCQ 1056 Query: 539 NLQQDYELKV-EQYVHLLDIRAARIHKLEAQ 568 ++ + + E+ V L IR KL A+ Sbjct: 1057 EIEIYLKQTISEKEVELQHIRKDLEEKLAAE 1087 Score = 61.2 bits (147), Expect = 6e-09 Identities = 104/525 (19%), Positives = 215/525 (40%), Gaps = 81/525 (15%) Query: 37 KSRQAVSRVSREELEDR---FLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYE 93 K ++ + + +E L R + ++ L++ ++Q+D R+ + K E Sbjct: 1171 KEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDE---QSKENE 1227 Query: 94 RVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNET--LKNRLISAKQQLQTQGYRQT--- 148 +G ++L +++ E I+ + E + T L+ L A +Q TQ ++ Sbjct: 1228 NIGDQLRQL--QIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLC 1285 Query: 149 ----PYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEA 204 ++ S + G A A L+E + ++ + V+ T S L + Sbjct: 1286 PDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELE-LKVSST---------TSELTKK 1335 Query: 205 RGEIRNLENVIQSQRGQIEELE---HLAEILKTQLRRKENEIELSLLQLREQQATDQRSN 261 E+ L+ I Q +IE L+ H AE+ L++K +L + L + + + Sbjct: 1336 SEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLD 1395 Query: 262 IRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQR 321 +L K + +K +S + G QL EK+ L ++ ++ EQ Sbjct: 1396 --------ELQKLISKKEEDVSYLSG---QLSEKEAALT-----------KIQTEIIEQE 1433 Query: 322 LKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLK 381 L K LH+ E + +E +RI L+ E +K+ +++ E+ + K Sbjct: 1434 ----DLIKALHTQL--EMQAKEHDERIKQLQVELCEMKQKPEEI---------GEESRAK 1478 Query: 382 EQ-QLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDE 440 +Q Q K+Q A + K L + + + L R E+L + +++ Q Q ++ D Sbjct: 1479 QQIQRKLQAALISR--KEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDT 1536 Query: 441 LKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQA 500 + R+ L +E D E+ +LL + + + L + +D E+ ++E+++ Sbjct: 1537 VLGRLALLQEERDKLITEMDRSLL----ENQSLSSSCESLKLALEGLTEDKEKLVKEIES 1592 Query: 501 THAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYE 545 + + E + + +K+ Q E E + + EN+ + E Sbjct: 1593 LKSSKIAESTEWQEK-------HKELQKEYEILLQSYENVSNEAE 1630 Score = 58.9 bits (141), Expect = 3e-08 Identities = 135/626 (21%), Positives = 268/626 (42%), Gaps = 94/626 (15%) Query: 48 EELEDRFLRLHDENILLKQHARKQ-----------EDKIKRMATKLIRLVNDKKRYERVG 96 +EL+ L D+N L Q +Q ED++++ + ++ + +N + Sbjct: 389 QELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHET 448 Query: 97 GGPKRL------GRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYR---Q 147 G EE I LQ++V ELE + L I ++L+ + + Q Sbjct: 449 ASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIEL-EELKAENEKLSSQ 507 Query: 148 TPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDA--DVAETPHPMFTKYGNSLL---E 202 Q+R R+ +E + + ++ +++ DV E K + LL + Sbjct: 508 ITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMK 567 Query: 203 EARGEIRNLENVIQSQRGQIEELEHLAEIL-KTQLRRKENE----IELSLLQLREQQATD 257 EA+ EI L+ +Q +R EE +H E+L + ++++ E E I++ + Q Sbjct: 568 EAQEEIAFLKLQLQGKRA--EEADH--EVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFP 623 Query: 258 QRSNIRDNVEMIKLHKQLVEKSNALS---AMEGKFIQL----QEKQRTLRISHDALMANG 310 N ++ ++ + E + S ++ ++L Q+ ++L D + Sbjct: 624 LMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQ 683 Query: 311 DELNMQLKEQRLKCCSLEKQLH-SMKFSERRIEELQDRINDLEKERELLKENYDKLYDSA 369 DEL +LK Q L+ LE H + + E+ ++E I++L + E K+N D SA Sbjct: 684 DELE-RLKSQILE---LELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADN-NSSA 738 Query: 370 FSAAHEEQWKLKEQ---------------QLKVQIAQLETALKSDLTDKTEILDRLKTER 414 F+A EE+ +L Q QL++ +A+ E + D +T D L TE+ Sbjct: 739 FTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQT-AHDNLLTEQ 797 Query: 415 DQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKN 474 + + ++++++++ L+ +LD+++ + E S + +++Q + K Sbjct: 798 IHSLSIEAKSKDVKIEVLQ--NELDDVQ-----------LQFSEQSTLIRSLQSQLQNKE 844 Query: 475 GDLSFLVKVDSEINKDLER-----SMRELQATHAETVQELEKTRNMLIMQHKINKDYQME 529 ++ + I+ +E S +EL+ T + + LEK R++ +Q I + Q Sbjct: 845 SEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLL-LEKKRDVETLQQTIEEKDQQV 903 Query: 530 VE---AVTRKMENLQQD-YELKVE-----QYVHLLDIRAARIHKLEAQL-KDIAYGTKQY 579 E ++T KM L ++ + L VE + ++LL RA K + + +++ G KQ Sbjct: 904 TEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLS-RAEEAKKEQVEEDNEVSSGLKQN 962 Query: 580 KFKPEIMPDDSVDEFDETIHLERGEN 605 + S +E L + EN Sbjct: 963 YDEMSPAGQISKEELQHEFDLLKKEN 988 Score = 56.2 bits (134), Expect = 2e-07 Identities = 108/533 (20%), Positives = 231/533 (43%), Gaps = 72/533 (13%) Query: 108 MEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQ-TPYNNVQSRINTGRRKANE 166 +E+ EQLQ+K+ E + + + ++ L+ + +Q YN +Q + + + K NE Sbjct: 1169 LEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDE-QSKENE 1227 Query: 167 NAG-----LQECPRKGI--KFQDADVAE----TP---HPMF----TKYGNSLLEEARGEI 208 N G LQ R+ I K D E TP P+F + +LE Sbjct: 1228 NIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLES----- 1282 Query: 209 RNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEM 268 NL S L+ + + + + KE E E L+L+ T + + + + E+ Sbjct: 1283 -NLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELT--KKSEEV 1339 Query: 269 IKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLE 328 +L +Q+ ++ + +++ +SH+A + + L +L+ +L+ LE Sbjct: 1340 FQLQEQINKQGLEIESLK-------------TVSHEA-EVHAESLQQKLESSQLQIAGLE 1385 Query: 329 KQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFS------AAHEEQWKLKE 382 ++ + +++ELQ I+ E++ L + ++A + E+ K Sbjct: 1386 ----HLRELQPKLDELQKLISKKEEDVSYLSGQLSE-KEAALTKIQTEIIEQEDLIKALH 1440 Query: 383 QQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDE-- 440 QL++Q + + +K + E+ + + +++ Q R+LQ + +K+ L E Sbjct: 1441 TQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENK 1500 Query: 441 -LKKRIKLYNQENDINADELSEALLLIKAQKEQKN---GDLSFLVKVDSEINKDLERSMR 496 L++ + L + L++ + AQ ++K+ G L+ L + ++ +++RS+ Sbjct: 1501 SLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLL 1560 Query: 497 ELQATHAE------TVQELEKTRNMLIMQHKINKDYQM-EVEAVTRKMENLQQDYELKVE 549 E Q+ + ++ L + + L+ + + K ++ E K + LQ++YE+ ++ Sbjct: 1561 ENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQ 1620 Query: 550 QYVHLLDIRAARIHKLEA--QLKDIAYG----TKQYKFKPEIMPDDSVDEFDE 596 Y ++ + H +EA Q K YG T+ K + E ++ E +E Sbjct: 1621 SYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEE 1673 Score = 55.5 bits (132), Expect = 3e-07 Identities = 85/431 (19%), Positives = 181/431 (41%), Gaps = 55/431 (12%) Query: 112 IEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQ 171 IE L+ HE E E+L+ +L S+ QLQ G + + K +E L Sbjct: 1353 IESLKTVSHEAEVHAESLQQKLESS--QLQIAGLEH---------LRELQPKLDELQKLI 1401 Query: 172 ECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEI 231 + + + ++E + TK ++E+ I+ L ++ Q + +E ++ Sbjct: 1402 SKKEEDVSYLSGQLSEKEAAL-TKIQTEIIEQ-EDLIKALHTQLEMQAKEHDERIKQLQV 1459 Query: 232 LKTQLRRKENEI------------ELSLLQLREQQATDQRSNIRDNVEMIK-----LHKQ 274 ++++K EI +L + ++A + ++++ + + + L K Sbjct: 1460 ELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKS 1519 Query: 275 LVEKSNALSAME-------GKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSL 327 L + + +SA G+ LQE++ L D + L+ + +L L Sbjct: 1520 LADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGL 1579 Query: 328 E-------KQLHSMKFSE-RRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWK 379 K++ S+K S+ E Q++ +L+KE E+L ++Y+ + + A H + Sbjct: 1580 TEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAV 1639 Query: 380 LKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLD 439 +E+Q +L L+S +K E +L+ + E++ ++ R+ ++ +L+ Sbjct: 1640 RQEKQ------ELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELE 1693 Query: 440 ELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQ 499 E R++ A E E LL A +++ VK++ E +S+ + Sbjct: 1694 EENDRLRAEVHPAGDTAKECMETLLSSNASMKEE----LERVKMEYETLSKKFQSLMSEK 1749 Query: 500 ATHAETVQELE 510 + +E VQ+L+ Sbjct: 1750 DSLSEEVQDLK 1760 Score = 54.7 bits (130), Expect = 5e-07 Identities = 86/450 (19%), Positives = 193/450 (42%), Gaps = 49/450 (10%) Query: 75 IKRMATKLIRLVNDKKRYERVGGGPKRLGRDVE-MEEMIEQLQEKVHELEKQNETLKNRL 133 +++ A K + + DK + E K L D M E +E+V EL + ++ +L Sbjct: 2665 VQKEAAKKVGEIEDKLKKEL-----KHLHHDAGIMRNETETAEERVAELARDLVEMEQKL 2719 Query: 134 ISAKQQLQTQGYRQTPYNNVQSRINTGRRKANE---------NAGLQECPR---KGI--K 179 + ++ + + + S + R ANE +A L+E + +G+ + Sbjct: 2720 LMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNR 2779 Query: 180 FQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRK 239 +DA ++ET M + NSL +LE + Q + E+L HL+ +QL Sbjct: 2780 ERDALLSETAFSMNSTEENSL--------SHLEKLNQQLLSKDEQLLHLS----SQLEDS 2827 Query: 240 ENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTL 299 N+++ + Q ++R ++ + +E + ++ ++S A + +Q +L Sbjct: 2828 YNQVQSFSKAMASLQ--NERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQ------SL 2879 Query: 300 RISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLE-KERELL 358 + + +L + D L +LK + + + +++ + + +++E QD+ + + EL Sbjct: 2880 KKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELR 2939 Query: 359 KENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNE 418 +EN ++ + W++ E+++K Q + L+ ++ L++ Q + Sbjct: 2940 QENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQ 2999 Query: 419 KL-VQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDL 477 L VQ R+ + L +L + + + E+ + L I +Q N + Sbjct: 3000 PLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRI----QQLNSNF 3055 Query: 478 SFLVKVDSEIN---KDLERSMRELQATHAE 504 S L++ + ++ D +S+RE Q + + Sbjct: 3056 SQLLEEKNTLSIQLCDTSQSLRENQQHYGD 3085 Score = 51.6 bits (122), Expect = 5e-06 Identities = 119/629 (18%), Positives = 248/629 (39%), Gaps = 113/629 (17%) Query: 29 ETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVND 88 ET + Q V+ +S + ++ ++L++E L + ++++ ++ Sbjct: 890 ETLQQTIEEKDQQVTEISFS-MTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQ 948 Query: 89 KKRYERVGGGPKRLGRDVEMEEMI--EQLQEKVHELEKQNETLKNR----LISAKQQLQT 142 + V G K+ ++ I E+LQ + L+K+NE K + LI+ K+ LQ Sbjct: 949 VEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQR 1008 Query: 143 QGYRQTPYNNVQSR-------INTGRRKANENAGLQECPRKGI--KFQDADVAETPHPMF 193 + N++ T R + E+ +E K + K Q+ ++ Sbjct: 1009 VSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEI-------- 1060 Query: 194 TKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQ 253 Y + E E++++ ++ + E+ + L + + L+ K N+I+L ++ E Sbjct: 1061 --YLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISEN 1118 Query: 254 QATDQR-------SNIRDNVEMIK----------------------------LHKQLVEK 278 QA Q+ ++ D+V ++K K+ ++K Sbjct: 1119 QAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQK 1178 Query: 279 --SNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKF 336 AL++ + + QEK+R LR + + L Q EQ + ++ QL ++ Sbjct: 1179 KLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQI 1238 Query: 337 SERR--------------------IEELQDRINDLEKERELLKENYDKLYDSAFSAAHEE 376 R +EE + + + +L+ N + S A Sbjct: 1239 QVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASAL 1298 Query: 377 QWKLKEQQLKVQIAQLE----------TALKSDLTDKTEILDRLKTERD------QNEKL 420 Q Q+K Q+ ++E ++ S+LT K+E + +L+ + + ++ K Sbjct: 1299 QGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKT 1358 Query: 421 VQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFL 480 V E+ + L+QK + +L+ + +E DEL + + +K D+S+L Sbjct: 1359 VSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLI-------SKKEEDVSYL 1411 Query: 481 VKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKD--YQMEVEAVTRKME 538 SE E ++ ++Q E ++ L MQ K + + Q++VE K + Sbjct: 1412 SGQLSE----KEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQK 1467 Query: 539 NLQQDYELKVEQYVHLLDIRAARIHKLEA 567 + E + +Q + ++AA I + EA Sbjct: 1468 PEEIGEESRAKQQIQ-RKLQAALISRKEA 1495 >gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapiens] Length = 436 Score = 85.1 bits (209), Expect = 4e-16 Identities = 85/443 (19%), Positives = 197/443 (44%), Gaps = 24/443 (5%) Query: 44 RVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKL----IRLVNDKKRYERVGGGP 99 R++ EEL+++ L +E L++ + + IK + KL I L + + E+ G Sbjct: 3 RITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVR 62 Query: 100 KRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINT 159 ++ G+ E E + + + +V E E Q + ++ + Q++ Q + + ++ Sbjct: 63 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ---EGQVREQEGQVRE 119 Query: 160 GRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQR 219 + E G ++ Q+ V E + + G + E G++R E ++ Q Sbjct: 120 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ--VREQEGQVREQEGQVREQE 177 Query: 220 GQIEELEHLAEILKTQLRRKENEI---------ELSLLQLREQQATDQRSNIRDNVEMIK 270 GQ+ E E + Q+ +E ++ + +Q +E+Q +Q +R E + Sbjct: 178 GQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMG 237 Query: 271 LHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQ 330 ++ V+K + + ++ QE+Q + M +E ++ KEQ + +Q Sbjct: 238 EQEEQVQKQEEQVQKQEEQMRKQEEQMR---EQEEQMREQEEQMLKQKEQTEQEEQTGEQ 294 Query: 331 LHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLK--VQ 388 M+ E ++ E ++++ + E++ +E K + + E+ W+ KEQ K Q Sbjct: 295 EEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWE-QKEQMWEQKEQMWKQEEQ 353 Query: 389 IAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLY 448 + + E ++ + ++++ + +Q K ++ R+ + Q EQK+Q+ E K++++ Sbjct: 354 MGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQ 413 Query: 449 NQENDINADELSEALLLIKAQKE 471 ++ +++ + + QKE Sbjct: 414 EEQMGEQKEQMRKQEEHMGEQKE 436 Score = 82.8 bits (203), Expect = 2e-15 Identities = 74/417 (17%), Positives = 191/417 (45%), Gaps = 22/417 (5%) Query: 104 RDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNV---QSRINTG 160 ++ E++E ++ ++ + E++ + LK +L + K L +G + V + ++ Sbjct: 12 KNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQVREQ 71 Query: 161 RRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRG 220 + E G ++ Q+ V E + + G + E G++R E ++ Q G Sbjct: 72 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ--VREQEGQVREQEGQVREQEG 129 Query: 221 QIEELEHLAEILKTQLRRKENEIELSLLQLREQ--QATDQRSNIRDNVEMIKLHK-QLVE 277 Q+ E E + Q+R +E ++ Q+REQ Q +Q +R+ ++ + Q+ E Sbjct: 130 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 189 Query: 278 KSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFS 337 + + EG Q+ E++ + + + +++ Q ++ R + + +Q ++ Sbjct: 190 QEGQMGEQEG---QMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQ 246 Query: 338 ERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQ-QLKVQIAQLETAL 396 E ++++ +++ + K+ E ++E +++ + E+ K KEQ + + Q + E + Sbjct: 247 EEQVQKQEEQ---MRKQEEQMREQEEQMREQ-----EEQMLKQKEQTEQEEQTGEQEEQM 298 Query: 397 KSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINA 456 + E ++++ + +Q + ++ + + Q EQK+Q+ E K+++ ++ Sbjct: 299 REQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQE 358 Query: 457 DELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLER--SMRELQATHAETVQELEK 511 +++ + ++ Q+EQ + K + ++ K E+ +E E ++E E+ Sbjct: 359 EQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEE 415 Score = 80.9 bits (198), Expect = 7e-15 Identities = 78/415 (18%), Positives = 186/415 (44%), Gaps = 31/415 (7%) Query: 107 EMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANE 166 E++E +LQE++ +E + ++ + K++L+T V+ + R + + Sbjct: 8 ELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQ 67 Query: 167 NAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELE 226 ++ Q+ V E + + G + E G++R E ++ Q GQ+ E E Sbjct: 68 -----------VREQEGQVREQEGQVREQEGQ--VREQEGQVREQEGQVREQEGQVREQE 114 Query: 227 HLAEILKTQLRRKENEIELSLLQLREQ--QATDQRSNIRDNVEMIKLHK-QLVEKSNALS 283 + Q+R +E ++ Q+REQ Q +Q +R+ ++ + Q+ E+ + Sbjct: 115 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR 174 Query: 284 AMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEE 343 EG Q++E++ +R + ++ Q ++ + ++KQ M E ++ + Sbjct: 175 EQEG---QVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRK 231 Query: 344 LQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDK 403 ++++ + E++ + +E K EEQ + +E+Q++ Q Q+ + L K Sbjct: 232 QEEQMGEQEEQVQKQEEQVQK---------QEEQMRKQEEQMREQEEQMREQEEQMLKQK 282 Query: 404 --TEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSE 461 TE ++ + +Q + ++ RE + Q EQ++Q+ E ++++ ++ +++ E Sbjct: 283 EQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWE 342 Query: 462 ALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNML 516 + Q+EQ + K + ++ K E MR+ + + +++ K + Sbjct: 343 QKEQMWKQEEQMGEQEEQMQKQEEQVRKQ-EEQMRKQEEQMRKQEEQMRKQEEQM 396 Score = 49.7 bits (117), Expect = 2e-05 Identities = 60/361 (16%), Positives = 163/361 (45%), Gaps = 14/361 (3%) Query: 228 LAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEG 287 + I +L+ K E++ L QL E + ++ + +I++ ++ K + + + EG Sbjct: 1 MPRITNEELKEKNAELQEEL-QLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEG 59 Query: 288 KFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDR 347 Q++E++ +R + ++ Q + R + + +Q ++ E ++ E + + Sbjct: 60 ---QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 116 Query: 348 INDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEIL 407 + + E + ++E ++ + E++ +++EQ+ Q+ + E ++ E Sbjct: 117 VREQEGQ---VREQEGQVREQE-GQVREQEGQVREQE--GQVREQEGQVREQEGQVREQE 170 Query: 408 DRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIK 467 +++ + Q + + RE + Q EQ+ Q+ E ++++ ++ +++ E ++ Sbjct: 171 GQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMR 230 Query: 468 AQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQ 527 Q+EQ + K + ++ K E+ ++ + + Q E+ ML + + ++ Q Sbjct: 231 KQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQ 290 Query: 528 M-EVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQL---KDIAYGTKQYKFKP 583 E E R+ E ++ E ++ + + + ++ K E Q+ K+ + K+ +K Sbjct: 291 TGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQ 350 Query: 584 E 584 E Sbjct: 351 E 351 >gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sapiens] Length = 1116 Score = 83.6 bits (205), Expect = 1e-15 Identities = 125/605 (20%), Positives = 257/605 (42%), Gaps = 109/605 (18%) Query: 12 LPVKDTGLNLFGMGGLQETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQ 71 + +KD+ ++ G + +KS A+S REE E + + ++ + H++ Sbjct: 384 IEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREE-EMKQMEVY------RSHSKFM 436 Query: 72 EDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHEL---EKQNET 128 ++K++++ +L + + ++E + K G E+ ++ ++L K EL + + ET Sbjct: 437 KNKVEQLKEELS---SKEAQWEELK--KKAAGLQAEIGQVKQELSRKDTELLALQTKLET 491 Query: 129 LKNRLISAKQQLQTQGYRQTPYNN----VQSRINTGRRKANENAGLQECPRKGIKFQDAD 184 L N+ +KQ ++ T +Q+ ++ R + E + K I+ D Sbjct: 492 LTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQ----D 547 Query: 185 VAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEI- 243 +AE GEI +L++++ + ++ L+ E L+ QLR KE ++ Sbjct: 548 MAEEKGTQ------------AGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMS 595 Query: 244 ------------------------------ELSLLQLREQQATDQRSNIRDNVEMIKLHK 273 E ++ +L+EQ+ D+R + K K Sbjct: 596 SLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLK 655 Query: 274 QLVEKSNAL----SAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEK 329 L EK + L S E + L+E +L S + L + L++++ +C +E Sbjct: 656 DLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMES 715 Query: 330 QL---HSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLK 386 QL H R E+ DRI LE+E K+ K A E +L E + Sbjct: 716 QLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSK--------AQAEVDRLLEILKE 767 Query: 387 VQIAQLETALKSDLTDKTEILDRLKTE-RDQNEKLVQENRELQLQYLEQKQQLDELKKRI 445 V+ ++ DK + + L+ + +DQN+K+ + Q++ + Q L+E ++R Sbjct: 768 VE---------NEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRR- 817 Query: 446 KLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAET 505 + N ++ S+ L +K+ + +L ++ +I + E + + ++ Sbjct: 818 -------EDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNA 870 Query: 506 VQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKL 565 +++E+ +L+ K+ + E+E++ K+ + QQ E+ HL ++RA R L Sbjct: 871 EKQVEE---LLMAMEKV----KQELESMKAKLSSTQQSL---AEKETHLTNLRAERRKHL 920 Query: 566 EAQLK 570 E L+ Sbjct: 921 EEVLE 925 Score = 50.1 bits (118), Expect = 1e-05 Identities = 78/417 (18%), Positives = 181/417 (43%), Gaps = 41/417 (9%) Query: 175 RKGIKFQDADVAETPHPMFTKYGNSLLEEA---RGEIRNLENVIQSQRGQIEELEHLAEI 231 RK ++ +++ ++ + + + T + L +E + E + + R EE +H+ Sbjct: 169 RKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQ-- 226 Query: 232 LKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQ 291 + Q + E I+ L QL +Q ++ R+ E+ + + Q + + A E ++ Sbjct: 227 MTIQALQDELRIQRDLNQLFQQDSSS-RTGEPCVAELTEENFQRLHAEHERQAKELFLLR 285 Query: 292 --LQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLE------KQLHSMKFSERRIEE 343 L+E + + L A + + L+ + K S + ++ + +E + Sbjct: 286 KTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHH 345 Query: 344 LQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDK 403 L+ + EKE +L+E + +++A +A + + + +I+ +E L+ DL ++ Sbjct: 346 LESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLR-DLEEE 404 Query: 404 TEILDRLKTERDQNEKLVQENRELQLQYLE--------QKQQLDELKKRIKLYNQENDIN 455 ++L N L E RE +++ +E K ++++LK+ + + Sbjct: 405 IQML-------KSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEEL----SSKEAQ 453 Query: 456 ADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNM 515 +EL + ++A+ Q +LS + D+E+ L+ + L +++ Q +E + Sbjct: 454 WEELKKKAAGLQAEIGQVKQELS---RKDTEL-LALQTKLETLTNQFSDSKQHIEVLKES 509 Query: 516 LIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLD---IRAARIHKLEAQL 569 L + + Q EV+A+ ++E + K +Q + + +A IH L+ L Sbjct: 510 LTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDML 566 Score = 46.6 bits (109), Expect = 1e-04 Identities = 97/537 (18%), Positives = 216/537 (40%), Gaps = 60/537 (11%) Query: 11 DLPVKDTGLNLFGMGGLQETSTTRTMKSRQAVSRVSREEL---EDRFLRLHDENILLKQH 67 +L KDT L + ET T + S+Q + V +E L E R L E L+ Sbjct: 474 ELSRKDT--ELLALQTKLETLTNQFSDSKQHIE-VLKESLTAKEQRAAILQTEVDALRLR 530 Query: 68 ARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNE 127 ++E + + ++ + +K + G ++++M++ + KV+ L+K+ E Sbjct: 531 LEEKETMLNKKTKQIQDMAEEKGT---------QAGEIHDLKDMLDVKERKVNVLQKKIE 581 Query: 128 TLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQ-DADVA 186 L+ +L ++Q+ + R + +T E +E + +K Q D D Sbjct: 582 NLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDER 641 Query: 187 ETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEEL-EHLAEILKTQLRRKENEIEL 245 E + Y L ++ + ++ L+ + + + +L EH + + + L++ L Sbjct: 642 EKQEEI-DNYKKDL-KDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTL 699 Query: 246 SL-LQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQ-------- 296 + L+ ++++ S ++ E + E S+ + +E + + +++ Sbjct: 700 EIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVD 759 Query: 297 RTLRISHDALMANGD------ELNMQLKEQRLKCCSLE-KQLHSMKFSERRIEEL---QD 346 R L I + D EL Q+K+Q K +L+ K+ K S + +EE +D Sbjct: 760 RLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRRED 819 Query: 347 RIND---------------LEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQ 391 +ND +E+ E L+E+ + A EE + ++ ++ Sbjct: 820 NLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLM 879 Query: 392 LETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQE 451 +K +L L + + E + R + ++LE + L+ ++ + E Sbjct: 880 AMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLE--EVLEMKQEALLAAISE 937 Query: 452 NDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQE 508 D N ALL + + K++ +++ L + + + L++ + A+ ++ Sbjct: 938 KDANI-----ALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYED 989 >gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo sapiens] Length = 1937 Score = 82.8 bits (203), Expect = 2e-15 Identities = 140/662 (21%), Positives = 267/662 (40%), Gaps = 120/662 (18%) Query: 24 MGGLQETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHAR--KQEDKIKRMATK 81 M GL ET + K ++A+ ++ L+D NIL K + +Q D ++ + Sbjct: 985 MAGLDET-IAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQ 1043 Query: 82 LIRLVNDKKRYERVGGGPKRLGRD--VEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQ 139 +L D +R +R G +L ++ ++ME +QL EK LEK+ + N + + + Sbjct: 1044 EKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEK---LEKKEFEISNLISKIEDE 1100 Query: 140 LQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNS 199 + Q +Q+RI + E + R + Q +D++ + + Sbjct: 1101 QAVEIQLQKKIKELQARIE----ELGEEIEAERASRAKAEKQRSDLSRELEEISER---- 1152 Query: 200 LLEEARGEI-------RNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLRE 252 LEEA G + E Q R +EE E + LR+K + S+ +L E Sbjct: 1153 -LEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHAD---SMAELGE 1208 Query: 253 QQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDE 312 Q DN++ +K +L++++ L++ D L +N + Sbjct: 1209 QI---------DNLQRVKQ-------------------KLEKEKSELKMETDDLSSNAEA 1240 Query: 313 LNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKEN---YDKLYDSA 369 ++ C SLE Q+ +K E EE Q INDL +R L+ Y + D Sbjct: 1241 ISKAKGNLEKMCRSLEDQVSELKTKE---EEQQRLINDLTAQRARLQTEAGEYSRQLDE- 1296 Query: 370 FSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQ------------- 416 A Q +Q QI +L+ L+ + K + L++ R Sbjct: 1297 -KDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQE 1355 Query: 417 ------------NEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALL 464 N ++ Q + + +++ ++L+E KK++ QE + + + ++ Sbjct: 1356 GKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCA 1415 Query: 465 LIKAQK--------------EQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELE 510 ++ K E+ N + L K +K L ++ + T AE + Sbjct: 1416 SLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQK 1475 Query: 511 KTRNMLIMQHKINKDYQM---EVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEA 567 ++R++ K+ Y+ ++E + R+ +NLQQ+ EQ +IH+LE Sbjct: 1476 ESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAE----GGKQIHELEK 1531 Query: 568 QLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENL-FEIHINKVTFSSEVLQASGD 626 K + + K EI +++E + ++ E G+ L ++ +N+V SEV + + Sbjct: 1532 IKKQVE------QEKCEIQA--ALEEAEASLEHEEGKILRIQLELNQV--KSEVDRKIAE 1581 Query: 627 KE 628 K+ Sbjct: 1582 KD 1583 Score = 67.8 bits (164), Expect = 6e-11 Identities = 122/599 (20%), Positives = 250/599 (41%), Gaps = 99/599 (16%) Query: 37 KSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVG 96 K A S R+ELE++ + L E L+ + + D + + +L+ +K + E Sbjct: 863 KDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLE--- 919 Query: 97 GGPKRLGRDVEMEEMIE--------QLQEKVHELEKQNETLKNRLISA-KQQLQTQGYRQ 147 K + E EE I +L+++ EL+K + L+ L K++ T+ + Sbjct: 920 AKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 979 Query: 148 TPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGE 207 + T + + E LQE ++ + A+ + ++L +A+ + Sbjct: 980 NLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKV----------NILTKAKTK 1029 Query: 208 IRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVE 267 LE + G +E+ + L L+ R+ E +++L+ Q++T N + ++ Sbjct: 1030 ---LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLA------QESTMDMENDKQQLD 1080 Query: 268 MIKLHKQLVEKSNALSAMEGKF---IQLQEKQRTLRISHDALMANGDELNMQLKEQRLKC 324 KL K+ E SN +S +E + IQLQ+K + L+ A +EL +++ +R Sbjct: 1081 E-KLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQ-------ARIEELGEEIEAERASR 1132 Query: 325 CSLEKQLHSMKFSERRIEELQDRIN----------DLEKEREL----LKENYDK--LYDS 368 EKQ + R +EE+ +R+ +L K+RE L+ + ++ L Sbjct: 1133 AKAEKQRSDL---SRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHE 1189 Query: 369 AFSAA-----HEEQWKLKE-----QQLKVQIAQLETALK---SDLTDKTEILDR------ 409 A AA + +L E Q++K ++ + ++ LK DL+ E + + Sbjct: 1190 AMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLE 1249 Query: 410 ------------LKTERDQNEKLVQ----ENRELQLQYLEQKQQLDELKKRIKLYNQEND 453 LKT+ ++ ++L+ + LQ + E +QLDE + ++ Sbjct: 1250 KMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQ 1309 Query: 454 INADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTR 513 + ++ E ++ + + KN L+ ++ L E Q AE + L K Sbjct: 1310 ASTQQIEELKHQLEEETKAKNA-LAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKAN 1368 Query: 514 NMLIM-QHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKD 571 + + + K D E + + L Q + + E++V ++ + A + K + +L++ Sbjct: 1369 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ-EAEEHVEAVNAKCASLEKTKQRLQN 1426 Score = 67.0 bits (162), Expect = 1e-10 Identities = 95/417 (22%), Positives = 178/417 (42%), Gaps = 62/417 (14%) Query: 230 EILKTQLRRKENEIELSLL-------QLREQQATDQRSNIRDNVEM-----IKLHKQLVE 277 E+ K++ +RKE E ++ L QL+ Q D ++ + E I+L ++ E Sbjct: 865 ELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKE 924 Query: 278 KSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFS 337 + E +L K+R L L + D+L + L + +EK+ H+ + Sbjct: 925 VTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK-------VEKEKHATENK 977 Query: 338 ERRIEE----LQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKL---KEQQLKVQIA 390 + + E L + I L KE++ L+E + + D A E++ + + +L+ Q+ Sbjct: 978 VKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDL--QAEEDKVNILTKAKTKLEQQVD 1035 Query: 391 QLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQ 450 LE +L+ + + + L+R K + + + KL QE+ + KQQLDE KL + Sbjct: 1036 DLEGSLEQEKKLRMD-LERAKRKLEGDLKLAQEST---MDMENDKQQLDE-----KLEKK 1086 Query: 451 ENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELE 510 E +I+ L+ K + EQ + L++ ++ELQA E +E+E Sbjct: 1087 EFEISN-------LISKIEDEQA-------------VEIQLQKKIKELQARIEELGEEIE 1126 Query: 511 KTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLK 570 R K D E+E ++ ++E +VE L R A KL L+ Sbjct: 1127 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVE----LNKKREAEFQKLRRDLE 1182 Query: 571 DIAYGTKQYKFKPEIMPDDSVDEFDETI-HLERGENLFEIHINKVTFSSEVLQASGD 626 + + DS+ E E I +L+R + E +++ ++ L ++ + Sbjct: 1183 EATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAE 1239 Score = 65.5 bits (158), Expect = 3e-10 Identities = 128/614 (20%), Positives = 258/614 (42%), Gaps = 123/614 (20%) Query: 58 HDENILLKQHARKQEDK--IKRMATKLIRLVNDKK---------RYERVGGGPKRLGRDV 106 HD ++L +Q+ +QE K ++R +K V + R E + K+L + + Sbjct: 1341 HDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1400 Query: 107 -EMEEMIEQLQEKVHELEKQNETLKNR----LISAKQQLQTQGYRQTPYNNVQSRINTGR 161 E EE +E + K LEK + L+N ++ ++ N ++ + Sbjct: 1401 QEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWK 1460 Query: 162 RKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSL--LEEARGEIRNLENVIQSQR 219 +K E E +K + ++ + + Y SL LE R E +NL+ I Sbjct: 1461 QKYEETQAELEASQKESRSLSTELFKVKNV----YEESLDQLETLRRENKNLQQEISDLT 1516 Query: 220 GQIEE---LEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEM----IKLH 272 QI E H E +K Q+ +++ EI+ +L + ++ +R +E+ ++ Sbjct: 1517 EQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVD 1576 Query: 273 KQLVEKSNALSAMEGKFIQLQEKQRT-----LRISHDALMAN----GD--ELNMQLKE-Q 320 +++ EK + ++ ++ E ++ +R +DAL GD E+ +QL Sbjct: 1577 RKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHAN 1636 Query: 321 RLKCCSL-----------EKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSA 369 RL SL E QLH + + R E+L++++ +E+ LL+ ++L+ A Sbjct: 1637 RLAAESLRNYRNTQGILKETQLH-LDDALRGQEDLKEQLAIVERRANLLQAEIEELW--A 1693 Query: 370 FSAAHEEQWKLKEQQL-----KVQ-------------------IAQLETAL--------- 396 E K+ EQ+L +VQ ++QL++ + Sbjct: 1694 TLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRN 1753 Query: 397 -----KSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQE 451 K +TD + + LK E+D + L + + L+ + + +LDE +++ L + Sbjct: 1754 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE-AEQLALKGGK 1812 Query: 452 NDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDL---ERSMRELQATHAETVQE 508 I ++A+ + G++ K ++E K L ER ++EL T Q Sbjct: 1813 KQIQK---------LEARVRELEGEVENEQKRNAEAVKGLRKHERRVKEL------TYQT 1857 Query: 509 LEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHL----------LDIR 558 E +N+L +Q ++K Q +V++ R+ E ++ + ++ L DI Sbjct: 1858 EEDRKNVLRLQDLVDK-LQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIA 1916 Query: 559 AARIHKLEAQLKDI 572 ++++KL + +++ Sbjct: 1917 ESQVNKLRVKSREV 1930 Score = 40.0 bits (92), Expect = 0.014 Identities = 49/228 (21%), Positives = 101/228 (44%), Gaps = 16/228 (7%) Query: 391 QLETALKSDLTDKT-----EILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRI 445 +++ LKS T+K E + K E ++E +E E + L++K L ++ Sbjct: 838 KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDL-----QL 892 Query: 446 KLYNQENDI-NADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAE 504 ++ ++ + + +A+E E L+ K Q E K +++ + + EIN +L R+L+ +E Sbjct: 893 QVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSE 952 Query: 505 TVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHK 564 ++++ L K + +V+ +T +M L + ++ L + + Sbjct: 953 LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDD 1012 Query: 565 LEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDE----TIHLERGENLFE 608 L+A+ + TK K K E DD ++ + LER + E Sbjct: 1013 LQAEEDKVNILTKA-KTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE 1059 >gi|34577114 cytomatrix protein p110 [Homo sapiens] Length = 957 Score = 82.0 bits (201), Expect = 3e-15 Identities = 127/604 (21%), Positives = 253/604 (41%), Gaps = 91/604 (15%) Query: 29 ETSTTRTMKSRQAVSRVS-------REELEDRFLR--LHDENILLKQHARKQ--EDKIKR 77 E RT + +A S+VS ++E E+ LR LH + L + A+ + + I+ Sbjct: 323 EDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEM 382 Query: 78 MATKL------IRLVNDKKRYERVGGGPKRLGRDVEMEEM------IEQLQEKVHELEKQ 125 TK+ IR + D+ + + G R+ E++++ + ++ K+ +L+++ Sbjct: 383 KDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQE 442 Query: 126 NETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADV 185 ++ L++ + +L+T + + + + A + + ++ + + Sbjct: 443 LSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLR-LEE 501 Query: 186 AETPHPMFTKYGNSLLEEA---RGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENE 242 E+ TK L EE GEIR+++++++ + +I L+ E L+ QLR K+ + Sbjct: 502 KESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQ 561 Query: 243 I-------------------------------ELSLLQLREQQATDQRSNIRDNVEMIKL 271 + E + +L+EQ+ D R + + K Sbjct: 562 LTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKE 621 Query: 272 HKQLVEKSNALSA----MEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSL 327 +K L EK NAL A E I L+E +L + + L + +++++ +C L Sbjct: 622 NKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKL 681 Query: 328 EKQL---HSMKFSERRIEELQDRINDLEKERELLKE-------NYDKLYDSAFSAAHEEQ 377 E QL H+++ R E D+I L+KE ++ D+L + +E+ Sbjct: 682 EAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKN 741 Query: 378 WKLKEQQLKVQIAQLETALKSDLTDKTEILDRLK----TERDQNEKLVQE--NRELQLQY 431 K K +IA+LE+ + D+ + + LK E+ +N +L++E RE + Sbjct: 742 DKDK------KIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMAD 795 Query: 432 LEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDL 491 Q Q++EL ++ QE D L+ + A+KE + L + E K L Sbjct: 796 NSQHLQIEELMNALEKTRQELDATKARLASTQQSL-AEKE------AHLANLRIERRKQL 848 Query: 492 ERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQY 551 E + Q + E + +L + K Q EV A+ R+ + L + + + Sbjct: 849 EEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQLKQQTQNR 908 Query: 552 VHLL 555 + L+ Sbjct: 909 MKLM 912 Score = 55.5 bits (132), Expect = 3e-07 Identities = 98/474 (20%), Positives = 198/474 (41%), Gaps = 67/474 (14%) Query: 104 RDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRK 163 R V M++ LQ ++ EL+++N+ L+ L +L + + + + + RK Sbjct: 140 RQVRDSTMLD-LQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRK 198 Query: 164 ANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIE 223 +E R + + V+ + +L +E R + R+L +++Q + G Sbjct: 199 -------EEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQ-RDLNHLLQQESGNRG 250 Query: 224 ELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALS 283 E+ + RR + E + +L + T + +R + L+ + L Sbjct: 251 AEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLE 310 Query: 284 AMEGKFIQLQ----EKQRTLR-------ISH-DALMANGDELNMQLKEQRLKCCSLEKQL 331 ++ K + + + +RT R +SH + ++ ++ N+ L+E+ + L+ + Sbjct: 311 MLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEP 370 Query: 332 HSMK-------FSERRIEELQDRINDLEKERELLKEN-YDKLYDSAFSAAHEEQWKLKEQ 383 K + +I L+ I DLE E ++LK N D E +K + Sbjct: 371 AKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSK 430 Query: 384 QLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKK 443 +K +I QL+ L ++ + +L+T +QN + KQ ++ LK+ Sbjct: 431 FMKTKIDQLKQELSKKESELLALQTKLETLSNQNS--------------DCKQHIEVLKE 476 Query: 444 RIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHA 503 + Q I E+ +AL L +KE SFL K ++ + + E + T A Sbjct: 477 SLTAKEQRAAILQTEV-DALRLRLEEKE------SFLNKKTKQL-----QDLTEEKGTLA 524 Query: 504 ETVQELEKTRNML-IMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLD 556 ++++ ++ML + + KIN + +K+ENLQ+ K +Q +L D Sbjct: 525 GEIRDM---KDMLEVKERKIN--------VLQKKIENLQEQLRDKDKQLTNLKD 567 >gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo sapiens] Length = 1972 Score = 80.9 bits (198), Expect = 7e-15 Identities = 121/605 (20%), Positives = 247/605 (40%), Gaps = 76/605 (12%) Query: 29 ETSTTRTMKSRQAVSRVSRE------ELEDRFLRLHDENILLKQHARKQEDKIK----RM 78 E + KSRQ + ++ R+ + ++ L + LK K+E++++ R+ Sbjct: 1040 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1099 Query: 79 ATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKV-----HELEKQNETLKNRL 133 ++ + N K+ + G L D++ E EK ELE L++ L Sbjct: 1100 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL 1159 Query: 134 ISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMF 193 S Q + + R+ ++ ++ R + A +QE +K H Sbjct: 1160 DSTATQQELRAKREQEVTVLKKALDEETR--SHEAQVQEMRQK-------------HAQA 1204 Query: 194 TKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEIL---KTQLRRKENEIELSLLQL 250 + LE+ + NL+ Q+ + +L +L K ++ K+ ++E + +L Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264 Query: 251 REQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFI-----------QLQEKQRTL 299 + + + +R+ N ++ KL ++ + L+ EGK I QLQ+ Q L Sbjct: 1265 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1324 Query: 300 RISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKER---- 355 + + +L +E+ L++++ + + ER I L +++D +K+ Sbjct: 1325 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1384 Query: 356 ---ELLKENYDKLYDSAFSAAHEEQWKL----KEQQLKVQIAQLETALKSDLTDKTEILD 408 E L+E + + + + K K ++ K ++ Q L DL ++ +++ Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444 Query: 409 RLKTERDQNEKLVQENRELQLQYLEQKQQLD------ELKKRIKLYNQENDINA-DELSE 461 L+ ++ + ++L+ E + + +Y +++ + + E K E + A +EL Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1504 Query: 462 ALLLIKAQKEQKNGDLSFLVKVDSEINKD---LERSMRELQATHAETVQELEKTR----- 513 ++KA+ E + K E+ K LE M E++ E EL+ T Sbjct: 1505 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1564 Query: 514 ---NMLIMQHKINKDYQMEVEAVTRKMENLQQ---DYELKVEQYVHLLDIRAARIHKLEA 567 NM ++ + +D Q E K LQ+ +YE ++E + AA KLE Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1624 Query: 568 QLKDI 572 LKD+ Sbjct: 1625 DLKDL 1629 Score = 78.6 bits (192), Expect = 3e-14 Identities = 130/606 (21%), Positives = 252/606 (41%), Gaps = 68/606 (11%) Query: 37 KSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVG 96 K RQ + +ELE + +L +E LL++ + + + +RL K+ E + Sbjct: 865 KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL 924 Query: 97 GGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSR 156 EME +E+ +++ +L+ + + + +++ ++QL+ + + + Sbjct: 925 H---------EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 975 Query: 157 INTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQ 216 +K + + + + + + E + T L E + +NL + Sbjct: 976 AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN-----LAEEEEKAKNLTKLKN 1030 Query: 217 SQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRD-NVEMIKLHKQL 275 I ELE + K + R+E E L + E A+D I D ++ +L QL Sbjct: 1031 KHESMISELE--VRLKKEEKSRQELE---KLKRKLEGDASDFHEQIADLQAQIAELKMQL 1085 Query: 276 VEKSNALSAMEGKF-IQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSM 334 +K L A + ++ +K L+ + L + +L L +R EKQ + Sbjct: 1086 AKKEEELQAALARLDDEIAQKNNALKKIRE-LEGHISDLQEDLDSERAARNKAEKQKRDL 1144 Query: 335 -KFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLE 393 + E EL+D ++ ++EL + ++ + A +E+ + E Q++ ++ Q Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEV--TVLKKALDEETRSHEAQVQ-EMRQKH 1201 Query: 394 TALKSDLTDKTEILDRLKTERDQNEK-LVQENREL--QLQYLEQ-KQQLDELKKRIKLYN 449 +LT++ E R K D+N++ L +EN +L +L+ L Q KQ+++ KK+++ Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1261 Query: 450 QENDINAD-------ELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATH 502 QE EL++ + ++ + E G L+ ++ KD+ +LQ T Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321 Query: 503 AETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARI 562 E +Q E+TR L + K+ Q+E E R Q D E++ +Q + I Sbjct: 1322 -ELLQ--EETRQKLNVSTKLR---QLEEE---RNSLQDQLDEEMEAKQNLE------RHI 1366 Query: 563 HKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIH-LERGENLFEIHINKVTFSSEVL 621 L QL D + +F T+ LE G+ F+ I +T E Sbjct: 1367 STLNIQLSD---------------SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEK 1411 Query: 622 QASGDK 627 A+ DK Sbjct: 1412 AAAYDK 1417 Score = 75.9 bits (185), Expect = 2e-13 Identities = 125/557 (22%), Positives = 229/557 (41%), Gaps = 79/557 (14%) Query: 48 EELEDRFLRLHDENILLKQHARKQEDKIKRM--ATKLIRLVNDKKRYERVGGGPKRLGRD 105 EELE L D L A +QE + KR T L + ++++ R R Sbjct: 1146 EELEALKTELEDT---LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1202 Query: 106 VEMEEMIEQLQEKVH---ELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRR 162 +EE+ EQL++ L+K +TL+ +L+ G Q++ + Sbjct: 1203 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG---------QAKQEVEHK 1253 Query: 163 KANENAGLQECPRKGIKFQDA--DVAETPHPMFTKYGN--SLLEEARGEIRNLENVIQSQ 218 K A +QE K + A ++ + H + + + +L EA G+ L + S Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313 Query: 219 RGQIEELEHLAEILKTQLRRKENEIELSLLQLRE-----QQATDQRSNIRDNVEM----- 268 Q+++ + E+L+ + R+K N + L QL E Q D+ + N+E Sbjct: 1314 SSQLQDTQ---ELLQEETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369 Query: 269 -IKLH---KQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKC 324 I+L K+L + ++ + A+E + Q++ L ++ A D+L + + Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1429 Query: 325 CSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWK----- 379 L L + + +E+ Q + + L E + + Y D A + A E++ K Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1489 Query: 380 --LKEQ-QLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQ 436 L+E + K ++ + LK+++ D D + + EK R L+ Q E K Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK---SKRALETQMEEMKT 1546 Query: 437 QLDELKKRIKLYNQENDINADELSEALLLIKAQ--KEQKNGDLSFLVKVDSEINKDLERS 494 QL+EL E+++ A E ++ L + Q K Q DL + + E + L+R Sbjct: 1547 QLEEL---------EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1597 Query: 495 MRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHL 554 + E + ELE R + A +K+E +D EL+ + + Sbjct: 1598 LHEYET-------ELEDERKQRAL-----------AAAAKKKLEGDLKDLELQADSAIKG 1639 Query: 555 LDIRAARIHKLEAQLKD 571 + ++ KL+AQ+KD Sbjct: 1640 REEAIKQLRKLQAQMKD 1656 Score = 74.3 bits (181), Expect = 7e-13 Identities = 127/624 (20%), Positives = 256/624 (41%), Gaps = 61/624 (9%) Query: 28 QETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVN 87 +E + + ++ + + ++LED L + D+N L + + E++I + T L Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020 Query: 88 DKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQ 147 K ++ K E+E +++ ++ ELEK L+ +Q+ Sbjct: 1021 KAKNLTKLKN--KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA------ 1072 Query: 148 TPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGE 207 ++Q++I + + A +E + + D ++A+ + + + E G Sbjct: 1073 ----DLQAQIAELKMQL---AKKEEELQAALARLDDEIAQKNNAL------KKIRELEGH 1119 Query: 208 IRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVE 267 I +L+ + S+R + E L +L + E+E +L + AT Q + E Sbjct: 1120 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL----DSTATQQELRAKREQE 1175 Query: 268 MIKLHKQLVEKSNALSA----MEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQ--- 320 + L K L E++ + A M K Q E+ AN D+ L+++ Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1235 Query: 321 ---RLKCCSLEKQ--LHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHE 375 L+ KQ H K E +++ELQ + +D E+ R L + KL + S Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT-- 1293 Query: 376 EQWKLKEQQLK-VQIAQLETALKSDLTDKTEILDRLKTERDQN-----EKLVQENRELQL 429 L E + K +++A+ +L S L D E+L +T + N +L +E LQ Sbjct: 1294 --GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE-ETRQKLNVSTKLRQLEEERNSLQD 1350 Query: 430 QYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKN------GDLSFLVKV 483 Q E+ + L++ I N + + +L + ++A +E K +L+ + Sbjct: 1351 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1410 Query: 484 DSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQM---EVEAVTRKMENL 540 + LE++ LQ + V +L+ R ++ K + + E + ++ K + Sbjct: 1411 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADE 1470 Query: 541 QQDYELKV-EQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIH 599 + E + E+ L + A LEA+ +++ K K + E + S D+ + +H Sbjct: 1471 RDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDLV-SSKDDVGKNVH 1528 Query: 600 -LERGENLFEIHINKVTFSSEVLQ 622 LE+ + E + ++ E L+ Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELE 1552 Score = 70.9 bits (172), Expect = 7e-12 Identities = 121/601 (20%), Positives = 252/601 (41%), Gaps = 102/601 (16%) Query: 27 LQETSTTRTMKSRQAVSRVSR-EELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRL 85 LQ+T ++RQ ++ ++ +LE+ L D+ L + +++ + ++T I+L Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ---LDEEMEAKQNLERHISTLNIQL 1373 Query: 86 VNDKKRY-------ERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQ 138 + KK+ E + G KR + E+E + +Q +EK +K +T KNRL Sbjct: 1374 SDSKKKLQDFASTVEALEEGKKRFQK--EIENLTQQYEEKAAAYDKLEKT-KNRLQQELD 1430 Query: 139 QL--QTQGYRQTPYN----------------NVQSRINTGRRKANENAGLQECPRKGIK- 179 L RQ N N+ S+ R +A A +E + Sbjct: 1431 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1490 Query: 180 -----FQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRG---QIEELEHLAEI 231 + + E + M L+ +N+ + +S+R Q+EE++ E Sbjct: 1491 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1550 Query: 232 LKTQLRRKEN---EIELSL----------LQLREQQATDQRSNIRDNVEMIKLHKQLVEK 278 L+ +L+ E+ +E+++ LQ R++Q ++R ++ + + + K Sbjct: 1551 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1610 Query: 279 SNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFS- 337 AL+A K +L+ + L + D+ + +E QL++ + + +++L + S Sbjct: 1611 QRALAAAAKK--KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR 1668 Query: 338 ----------ERRIEELQDRINDLE----------KERELLKENYDKLYDSAFSAAHEEQ 377 E++ + L+ + L+ K+ +L KE + S+ S + Q Sbjct: 1669 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1728 Query: 378 WKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQE---NRELQLQYLEQ 434 + +++L+ +IAQLE L+ + + + DR++ Q E+L E R + Sbjct: 1729 DE--KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786 Query: 435 KQQLDELKK--RIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLE 492 +QQL+ K R KL+ E A K + ++ L +++ + +E Sbjct: 1787 RQQLERQNKELRSKLHEMEG---------------AVKSKFKSTIAALEAKIAQLEEQVE 1831 Query: 493 RSMRELQATHAETVQELEKTRNMLIM---QHKINKDYQMEVEAVTRKMENLQQDYELKVE 549 + RE QA Q+ +K + +L+ + K+ + Y+ + E +++ L++ E E Sbjct: 1832 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1891 Query: 550 Q 550 + Sbjct: 1892 E 1892 Score = 70.5 bits (171), Expect = 1e-11 Identities = 80/386 (20%), Positives = 177/386 (45%), Gaps = 45/386 (11%) Query: 214 VIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEM----- 268 ++Q R + E E+ KT+ R+++ E EL L+ + Q T++++ +++ ++ Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903 Query: 269 -------IKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQR 321 ++L + E L ME + + +++ + L+ + +L QL+E+ Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963 Query: 322 LKCCSLEKQLHSMKFSERRIEE----LQDRINDLEKERELLKENYDKLYDSAFSAAHEEQ 377 L+ + + + +++E+ + D+ N L KER+LL+E ++ D + A EE+ Sbjct: 964 AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE---RISDLTTNLAEEEE 1020 Query: 378 WKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQ 437 K K + +L+ +S ++ E+ RLK E ++L + R+L+ + +Q Sbjct: 1021 -KAKN------LTKLKNKHESMIS---ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070 Query: 438 LDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVD---SEINKDL--- 491 + +L+ +I + +EL AL + + QKN L + +++ S++ +DL Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130 Query: 492 -------ERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDY 544 E+ R+L ELE T + Q ++ + EV + + ++ + + Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190 Query: 545 ELKVEQYVHLLDIRAARIHKLEAQLK 570 E +V++ + A + +L QL+ Sbjct: 1191 EAQVQE---MRQKHAQAVEELTEQLE 1213 Score = 66.6 bits (161), Expect = 1e-10 Identities = 102/489 (20%), Positives = 206/489 (42%), Gaps = 83/489 (16%) Query: 39 RQAVSRVSREELEDRFLRLHDENILLKQ---------HARKQEDKIKRMATKLIRLVNDK 89 RQ VS + +++ + L ++NI K AR++E K +A L + K Sbjct: 1440 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1499 Query: 90 KRYERVGGGPKRLGRDVEMEEMI---EQLQEKVHELEKQNETLKNRLISAKQQLQT--QG 144 + ER K EME+++ + + + VHELEK L+ ++ K QL+ Sbjct: 1500 EELERTNKMLK-----AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554 Query: 145 YRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEA 204 + T ++ +N K LQ Q+ + +Y L +E Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDE-----QNEEKRRQLQRQLHEYETELEDER 1609 Query: 205 R-------------GEIRNLE----NVIQSQRGQIEELEHLAEILKTQLRR--------- 238 + G++++LE + I+ + I++L L +K R Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1669 Query: 239 ------KENE-----IELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEG 287 KENE +E L+QL+E A +R+ + ++E +L ++L + +A++ Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD 1729 Query: 288 KFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDR 347 + +L+ + L + N + ++ ++++ + L +L + + + ++ E + + Sbjct: 1730 EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ 1789 Query: 348 INDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEIL 407 LE++ KE KL++ A + ++K L+ +IAQLE ++ + +K Sbjct: 1790 ---LERQN---KELRSKLHE--MEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1841 Query: 408 DRLKTERDQNEKL---VQENRELQLQYLEQ-----------KQQLDELKKRIKLYNQEND 453 LK + + +++ V++ R++ QY EQ K+QL+E ++ + N Sbjct: 1842 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1901 Query: 454 INADELSEA 462 EL EA Sbjct: 1902 KLQRELDEA 1910 >gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo sapiens] Length = 1979 Score = 80.9 bits (198), Expect = 7e-15 Identities = 121/605 (20%), Positives = 247/605 (40%), Gaps = 76/605 (12%) Query: 29 ETSTTRTMKSRQAVSRVSRE------ELEDRFLRLHDENILLKQHARKQEDKIK----RM 78 E + KSRQ + ++ R+ + ++ L + LK K+E++++ R+ Sbjct: 1047 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1106 Query: 79 ATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKV-----HELEKQNETLKNRL 133 ++ + N K+ + G L D++ E EK ELE L++ L Sbjct: 1107 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL 1166 Query: 134 ISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMF 193 S Q + + R+ ++ ++ R + A +QE +K H Sbjct: 1167 DSTATQQELRAKREQEVTVLKKALDEETR--SHEAQVQEMRQK-------------HAQA 1211 Query: 194 TKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEIL---KTQLRRKENEIELSLLQL 250 + LE+ + NL+ Q+ + +L +L K ++ K+ ++E + +L Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271 Query: 251 REQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFI-----------QLQEKQRTL 299 + + + +R+ N ++ KL ++ + L+ EGK I QLQ+ Q L Sbjct: 1272 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1331 Query: 300 RISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKER---- 355 + + +L +E+ L++++ + + ER I L +++D +K+ Sbjct: 1332 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1391 Query: 356 ---ELLKENYDKLYDSAFSAAHEEQWKL----KEQQLKVQIAQLETALKSDLTDKTEILD 408 E L+E + + + + K K ++ K ++ Q L DL ++ +++ Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451 Query: 409 RLKTERDQNEKLVQENRELQLQYLEQKQQLD------ELKKRIKLYNQENDINA-DELSE 461 L+ ++ + ++L+ E + + +Y +++ + + E K E + A +EL Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1511 Query: 462 ALLLIKAQKEQKNGDLSFLVKVDSEINKD---LERSMRELQATHAETVQELEKTR----- 513 ++KA+ E + K E+ K LE M E++ E EL+ T Sbjct: 1512 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1571 Query: 514 ---NMLIMQHKINKDYQMEVEAVTRKMENLQQ---DYELKVEQYVHLLDIRAARIHKLEA 567 NM ++ + +D Q E K LQ+ +YE ++E + AA KLE Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631 Query: 568 QLKDI 572 LKD+ Sbjct: 1632 DLKDL 1636 Score = 78.6 bits (192), Expect = 3e-14 Identities = 130/606 (21%), Positives = 252/606 (41%), Gaps = 68/606 (11%) Query: 37 KSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVG 96 K RQ + +ELE + +L +E LL++ + + + +RL K+ E + Sbjct: 872 KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL 931 Query: 97 GGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSR 156 EME +E+ +++ +L+ + + + +++ ++QL+ + + + Sbjct: 932 H---------EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 982 Query: 157 INTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQ 216 +K + + + + + + E + T L E + +NL + Sbjct: 983 AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN-----LAEEEEKAKNLTKLKN 1037 Query: 217 SQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRD-NVEMIKLHKQL 275 I ELE + K + R+E E L + E A+D I D ++ +L QL Sbjct: 1038 KHESMISELE--VRLKKEEKSRQELE---KLKRKLEGDASDFHEQIADLQAQIAELKMQL 1092 Query: 276 VEKSNALSAMEGKF-IQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSM 334 +K L A + ++ +K L+ + L + +L L +R EKQ + Sbjct: 1093 AKKEEELQAALARLDDEIAQKNNALKKIRE-LEGHISDLQEDLDSERAARNKAEKQKRDL 1151 Query: 335 -KFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLE 393 + E EL+D ++ ++EL + ++ + A +E+ + E Q++ ++ Q Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEV--TVLKKALDEETRSHEAQVQ-EMRQKH 1208 Query: 394 TALKSDLTDKTEILDRLKTERDQNEK-LVQENREL--QLQYLEQ-KQQLDELKKRIKLYN 449 +LT++ E R K D+N++ L +EN +L +L+ L Q KQ+++ KK+++ Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1268 Query: 450 QENDINAD-------ELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATH 502 QE EL++ + ++ + E G L+ ++ KD+ +LQ T Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328 Query: 503 AETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARI 562 E +Q E+TR L + K+ Q+E E R Q D E++ +Q + I Sbjct: 1329 -ELLQ--EETRQKLNVSTKLR---QLEEE---RNSLQDQLDEEMEAKQNLE------RHI 1373 Query: 563 HKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIH-LERGENLFEIHINKVTFSSEVL 621 L QL D + +F T+ LE G+ F+ I +T E Sbjct: 1374 STLNIQLSD---------------SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEK 1418 Query: 622 QASGDK 627 A+ DK Sbjct: 1419 AAAYDK 1424 Score = 75.9 bits (185), Expect = 2e-13 Identities = 125/557 (22%), Positives = 229/557 (41%), Gaps = 79/557 (14%) Query: 48 EELEDRFLRLHDENILLKQHARKQEDKIKRM--ATKLIRLVNDKKRYERVGGGPKRLGRD 105 EELE L D L A +QE + KR T L + ++++ R R Sbjct: 1153 EELEALKTELEDT---LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1209 Query: 106 VEMEEMIEQLQEKVH---ELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRR 162 +EE+ EQL++ L+K +TL+ +L+ G Q++ + Sbjct: 1210 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG---------QAKQEVEHK 1260 Query: 163 KANENAGLQECPRKGIKFQDA--DVAETPHPMFTKYGN--SLLEEARGEIRNLENVIQSQ 218 K A +QE K + A ++ + H + + + +L EA G+ L + S Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320 Query: 219 RGQIEELEHLAEILKTQLRRKENEIELSLLQLRE-----QQATDQRSNIRDNVEM----- 268 Q+++ + E+L+ + R+K N + L QL E Q D+ + N+E Sbjct: 1321 SSQLQDTQ---ELLQEETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376 Query: 269 -IKLH---KQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKC 324 I+L K+L + ++ + A+E + Q++ L ++ A D+L + + Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1436 Query: 325 CSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWK----- 379 L L + + +E+ Q + + L E + + Y D A + A E++ K Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1496 Query: 380 --LKEQ-QLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQ 436 L+E + K ++ + LK+++ D D + + EK R L+ Q E K Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK---SKRALETQMEEMKT 1553 Query: 437 QLDELKKRIKLYNQENDINADELSEALLLIKAQ--KEQKNGDLSFLVKVDSEINKDLERS 494 QL+EL E+++ A E ++ L + Q K Q DL + + E + L+R Sbjct: 1554 QLEEL---------EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1604 Query: 495 MRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHL 554 + E + ELE R + A +K+E +D EL+ + + Sbjct: 1605 LHEYET-------ELEDERKQRAL-----------AAAAKKKLEGDLKDLELQADSAIKG 1646 Query: 555 LDIRAARIHKLEAQLKD 571 + ++ KL+AQ+KD Sbjct: 1647 REEAIKQLRKLQAQMKD 1663 Score = 74.3 bits (181), Expect = 7e-13 Identities = 127/624 (20%), Positives = 256/624 (41%), Gaps = 61/624 (9%) Query: 28 QETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVN 87 +E + + ++ + + ++LED L + D+N L + + E++I + T L Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027 Query: 88 DKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQ 147 K ++ K E+E +++ ++ ELEK L+ +Q+ Sbjct: 1028 KAKNLTKLKN--KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA------ 1079 Query: 148 TPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGE 207 ++Q++I + + A +E + + D ++A+ + + + E G Sbjct: 1080 ----DLQAQIAELKMQL---AKKEEELQAALARLDDEIAQKNNAL------KKIRELEGH 1126 Query: 208 IRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVE 267 I +L+ + S+R + E L +L + E+E +L + AT Q + E Sbjct: 1127 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL----DSTATQQELRAKREQE 1182 Query: 268 MIKLHKQLVEKSNALSA----MEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQ--- 320 + L K L E++ + A M K Q E+ AN D+ L+++ Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1242 Query: 321 ---RLKCCSLEKQ--LHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHE 375 L+ KQ H K E +++ELQ + +D E+ R L + KL + S Sbjct: 1243 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT-- 1300 Query: 376 EQWKLKEQQLK-VQIAQLETALKSDLTDKTEILDRLKTERDQN-----EKLVQENRELQL 429 L E + K +++A+ +L S L D E+L +T + N +L +E LQ Sbjct: 1301 --GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE-ETRQKLNVSTKLRQLEEERNSLQD 1357 Query: 430 QYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKN------GDLSFLVKV 483 Q E+ + L++ I N + + +L + ++A +E K +L+ + Sbjct: 1358 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1417 Query: 484 DSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQM---EVEAVTRKMENL 540 + LE++ LQ + V +L+ R ++ K + + E + ++ K + Sbjct: 1418 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADE 1477 Query: 541 QQDYELKV-EQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIH 599 + E + E+ L + A LEA+ +++ K K + E + S D+ + +H Sbjct: 1478 RDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDLV-SSKDDVGKNVH 1535 Query: 600 -LERGENLFEIHINKVTFSSEVLQ 622 LE+ + E + ++ E L+ Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELE 1559 Score = 70.9 bits (172), Expect = 7e-12 Identities = 121/601 (20%), Positives = 252/601 (41%), Gaps = 102/601 (16%) Query: 27 LQETSTTRTMKSRQAVSRVSR-EELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRL 85 LQ+T ++RQ ++ ++ +LE+ L D+ L + +++ + ++T I+L Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ---LDEEMEAKQNLERHISTLNIQL 1380 Query: 86 VNDKKRY-------ERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQ 138 + KK+ E + G KR + E+E + +Q +EK +K +T KNRL Sbjct: 1381 SDSKKKLQDFASTVEALEEGKKRFQK--EIENLTQQYEEKAAAYDKLEKT-KNRLQQELD 1437 Query: 139 QL--QTQGYRQTPYN----------------NVQSRINTGRRKANENAGLQECPRKGIK- 179 L RQ N N+ S+ R +A A +E + Sbjct: 1438 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1497 Query: 180 -----FQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRG---QIEELEHLAEI 231 + + E + M L+ +N+ + +S+R Q+EE++ E Sbjct: 1498 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1557 Query: 232 LKTQLRRKEN---EIELSL----------LQLREQQATDQRSNIRDNVEMIKLHKQLVEK 278 L+ +L+ E+ +E+++ LQ R++Q ++R ++ + + + K Sbjct: 1558 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1617 Query: 279 SNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFS- 337 AL+A K +L+ + L + D+ + +E QL++ + + +++L + S Sbjct: 1618 QRALAAAAKK--KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR 1675 Query: 338 ----------ERRIEELQDRINDLE----------KERELLKENYDKLYDSAFSAAHEEQ 377 E++ + L+ + L+ K+ +L KE + S+ S + Q Sbjct: 1676 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1735 Query: 378 WKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQE---NRELQLQYLEQ 434 + +++L+ +IAQLE L+ + + + DR++ Q E+L E R + Sbjct: 1736 DE--KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793 Query: 435 KQQLDELKK--RIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLE 492 +QQL+ K R KL+ E A K + ++ L +++ + +E Sbjct: 1794 RQQLERQNKELRSKLHEMEG---------------AVKSKFKSTIAALEAKIAQLEEQVE 1838 Query: 493 RSMRELQATHAETVQELEKTRNMLIM---QHKINKDYQMEVEAVTRKMENLQQDYELKVE 549 + RE QA Q+ +K + +L+ + K+ + Y+ + E +++ L++ E E Sbjct: 1839 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1898 Query: 550 Q 550 + Sbjct: 1899 E 1899 Score = 70.5 bits (171), Expect = 1e-11 Identities = 80/386 (20%), Positives = 177/386 (45%), Gaps = 45/386 (11%) Query: 214 VIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEM----- 268 ++Q R + E E+ KT+ R+++ E EL L+ + Q T++++ +++ ++ Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910 Query: 269 -------IKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQR 321 ++L + E L ME + + +++ + L+ + +L QL+E+ Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970 Query: 322 LKCCSLEKQLHSMKFSERRIEE----LQDRINDLEKERELLKENYDKLYDSAFSAAHEEQ 377 L+ + + + +++E+ + D+ N L KER+LL+E ++ D + A EE+ Sbjct: 971 AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE---RISDLTTNLAEEEE 1027 Query: 378 WKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQ 437 K K + +L+ +S ++ E+ RLK E ++L + R+L+ + +Q Sbjct: 1028 -KAKN------LTKLKNKHESMIS---ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077 Query: 438 LDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVD---SEINKDL--- 491 + +L+ +I + +EL AL + + QKN L + +++ S++ +DL Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137 Query: 492 -------ERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDY 544 E+ R+L ELE T + Q ++ + EV + + ++ + + Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197 Query: 545 ELKVEQYVHLLDIRAARIHKLEAQLK 570 E +V++ + A + +L QL+ Sbjct: 1198 EAQVQE---MRQKHAQAVEELTEQLE 1220 Score = 66.6 bits (161), Expect = 1e-10 Identities = 102/489 (20%), Positives = 206/489 (42%), Gaps = 83/489 (16%) Query: 39 RQAVSRVSREELEDRFLRLHDENILLKQ---------HARKQEDKIKRMATKLIRLVNDK 89 RQ VS + +++ + L ++NI K AR++E K +A L + K Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1506 Query: 90 KRYERVGGGPKRLGRDVEMEEMI---EQLQEKVHELEKQNETLKNRLISAKQQLQT--QG 144 + ER K EME+++ + + + VHELEK L+ ++ K QL+ Sbjct: 1507 EELERTNKMLK-----AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561 Query: 145 YRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEA 204 + T ++ +N K LQ Q+ + +Y L +E Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDE-----QNEEKRRQLQRQLHEYETELEDER 1616 Query: 205 R-------------GEIRNLE----NVIQSQRGQIEELEHLAEILKTQLRR--------- 238 + G++++LE + I+ + I++L L +K R Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1676 Query: 239 ------KENE-----IELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEG 287 KENE +E L+QL+E A +R+ + ++E +L ++L + +A++ Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD 1736 Query: 288 KFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDR 347 + +L+ + L + N + ++ ++++ + L +L + + + ++ E + + Sbjct: 1737 EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ 1796 Query: 348 INDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEIL 407 LE++ KE KL++ A + ++K L+ +IAQLE ++ + +K Sbjct: 1797 ---LERQN---KELRSKLHE--MEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1848 Query: 408 DRLKTERDQNEKL---VQENRELQLQYLEQ-----------KQQLDELKKRIKLYNQEND 453 LK + + +++ V++ R++ QY EQ K+QL+E ++ + N Sbjct: 1849 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1908 Query: 454 INADELSEA 462 EL EA Sbjct: 1909 KLQRELDEA 1917 >gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo sapiens] Length = 1945 Score = 80.9 bits (198), Expect = 7e-15 Identities = 121/605 (20%), Positives = 247/605 (40%), Gaps = 76/605 (12%) Query: 29 ETSTTRTMKSRQAVSRVSRE------ELEDRFLRLHDENILLKQHARKQEDKIK----RM 78 E + KSRQ + ++ R+ + ++ L + LK K+E++++ R+ Sbjct: 1047 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1106 Query: 79 ATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKV-----HELEKQNETLKNRL 133 ++ + N K+ + G L D++ E EK ELE L++ L Sbjct: 1107 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL 1166 Query: 134 ISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMF 193 S Q + + R+ ++ ++ R + A +QE +K H Sbjct: 1167 DSTATQQELRAKREQEVTVLKKALDEETR--SHEAQVQEMRQK-------------HAQA 1211 Query: 194 TKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEIL---KTQLRRKENEIELSLLQL 250 + LE+ + NL+ Q+ + +L +L K ++ K+ ++E + +L Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271 Query: 251 REQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFI-----------QLQEKQRTL 299 + + + +R+ N ++ KL ++ + L+ EGK I QLQ+ Q L Sbjct: 1272 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1331 Query: 300 RISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKER---- 355 + + +L +E+ L++++ + + ER I L +++D +K+ Sbjct: 1332 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1391 Query: 356 ---ELLKENYDKLYDSAFSAAHEEQWKL----KEQQLKVQIAQLETALKSDLTDKTEILD 408 E L+E + + + + K K ++ K ++ Q L DL ++ +++ Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451 Query: 409 RLKTERDQNEKLVQENRELQLQYLEQKQQLD------ELKKRIKLYNQENDINA-DELSE 461 L+ ++ + ++L+ E + + +Y +++ + + E K E + A +EL Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1511 Query: 462 ALLLIKAQKEQKNGDLSFLVKVDSEINKD---LERSMRELQATHAETVQELEKTR----- 513 ++KA+ E + K E+ K LE M E++ E EL+ T Sbjct: 1512 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1571 Query: 514 ---NMLIMQHKINKDYQMEVEAVTRKMENLQQ---DYELKVEQYVHLLDIRAARIHKLEA 567 NM ++ + +D Q E K LQ+ +YE ++E + AA KLE Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631 Query: 568 QLKDI 572 LKD+ Sbjct: 1632 DLKDL 1636 Score = 78.6 bits (192), Expect = 3e-14 Identities = 130/606 (21%), Positives = 252/606 (41%), Gaps = 68/606 (11%) Query: 37 KSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVG 96 K RQ + +ELE + +L +E LL++ + + + +RL K+ E + Sbjct: 872 KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL 931 Query: 97 GGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSR 156 EME +E+ +++ +L+ + + + +++ ++QL+ + + + Sbjct: 932 H---------EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 982 Query: 157 INTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQ 216 +K + + + + + + E + T L E + +NL + Sbjct: 983 AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN-----LAEEEEKAKNLTKLKN 1037 Query: 217 SQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRD-NVEMIKLHKQL 275 I ELE + K + R+E E L + E A+D I D ++ +L QL Sbjct: 1038 KHESMISELE--VRLKKEEKSRQELE---KLKRKLEGDASDFHEQIADLQAQIAELKMQL 1092 Query: 276 VEKSNALSAMEGKF-IQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSM 334 +K L A + ++ +K L+ + L + +L L +R EKQ + Sbjct: 1093 AKKEEELQAALARLDDEIAQKNNALKKIRE-LEGHISDLQEDLDSERAARNKAEKQKRDL 1151 Query: 335 -KFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLE 393 + E EL+D ++ ++EL + ++ + A +E+ + E Q++ ++ Q Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEV--TVLKKALDEETRSHEAQVQ-EMRQKH 1208 Query: 394 TALKSDLTDKTEILDRLKTERDQNEK-LVQENREL--QLQYLEQ-KQQLDELKKRIKLYN 449 +LT++ E R K D+N++ L +EN +L +L+ L Q KQ+++ KK+++ Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1268 Query: 450 QENDINAD-------ELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATH 502 QE EL++ + ++ + E G L+ ++ KD+ +LQ T Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328 Query: 503 AETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARI 562 E +Q E+TR L + K+ Q+E E R Q D E++ +Q + I Sbjct: 1329 -ELLQ--EETRQKLNVSTKLR---QLEEE---RNSLQDQLDEEMEAKQNLE------RHI 1373 Query: 563 HKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIH-LERGENLFEIHINKVTFSSEVL 621 L QL D + +F T+ LE G+ F+ I +T E Sbjct: 1374 STLNIQLSD---------------SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEK 1418 Query: 622 QASGDK 627 A+ DK Sbjct: 1419 AAAYDK 1424 Score = 75.9 bits (185), Expect = 2e-13 Identities = 125/557 (22%), Positives = 229/557 (41%), Gaps = 79/557 (14%) Query: 48 EELEDRFLRLHDENILLKQHARKQEDKIKRM--ATKLIRLVNDKKRYERVGGGPKRLGRD 105 EELE L D L A +QE + KR T L + ++++ R R Sbjct: 1153 EELEALKTELEDT---LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1209 Query: 106 VEMEEMIEQLQEKVH---ELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRR 162 +EE+ EQL++ L+K +TL+ +L+ G Q++ + Sbjct: 1210 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG---------QAKQEVEHK 1260 Query: 163 KANENAGLQECPRKGIKFQDA--DVAETPHPMFTKYGN--SLLEEARGEIRNLENVIQSQ 218 K A +QE K + A ++ + H + + + +L EA G+ L + S Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320 Query: 219 RGQIEELEHLAEILKTQLRRKENEIELSLLQLRE-----QQATDQRSNIRDNVEM----- 268 Q+++ + E+L+ + R+K N + L QL E Q D+ + N+E Sbjct: 1321 SSQLQDTQ---ELLQEETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376 Query: 269 -IKLH---KQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKC 324 I+L K+L + ++ + A+E + Q++ L ++ A D+L + + Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1436 Query: 325 CSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWK----- 379 L L + + +E+ Q + + L E + + Y D A + A E++ K Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1496 Query: 380 --LKEQ-QLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQ 436 L+E + K ++ + LK+++ D D + + EK R L+ Q E K Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK---SKRALETQMEEMKT 1553 Query: 437 QLDELKKRIKLYNQENDINADELSEALLLIKAQ--KEQKNGDLSFLVKVDSEINKDLERS 494 QL+EL E+++ A E ++ L + Q K Q DL + + E + L+R Sbjct: 1554 QLEEL---------EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1604 Query: 495 MRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHL 554 + E + ELE R + A +K+E +D EL+ + + Sbjct: 1605 LHEYET-------ELEDERKQRAL-----------AAAAKKKLEGDLKDLELQADSAIKG 1646 Query: 555 LDIRAARIHKLEAQLKD 571 + ++ KL+AQ+KD Sbjct: 1647 REEAIKQLRKLQAQMKD 1663 Score = 74.3 bits (181), Expect = 7e-13 Identities = 127/624 (20%), Positives = 256/624 (41%), Gaps = 61/624 (9%) Query: 28 QETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVN 87 +E + + ++ + + ++LED L + D+N L + + E++I + T L Sbjct: 968 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027 Query: 88 DKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQ 147 K ++ K E+E +++ ++ ELEK L+ +Q+ Sbjct: 1028 KAKNLTKLKN--KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA------ 1079 Query: 148 TPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGE 207 ++Q++I + + A +E + + D ++A+ + + + E G Sbjct: 1080 ----DLQAQIAELKMQL---AKKEEELQAALARLDDEIAQKNNAL------KKIRELEGH 1126 Query: 208 IRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVE 267 I +L+ + S+R + E L +L + E+E +L + AT Q + E Sbjct: 1127 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL----DSTATQQELRAKREQE 1182 Query: 268 MIKLHKQLVEKSNALSA----MEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQ--- 320 + L K L E++ + A M K Q E+ AN D+ L+++ Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1242 Query: 321 ---RLKCCSLEKQ--LHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHE 375 L+ KQ H K E +++ELQ + +D E+ R L + KL + S Sbjct: 1243 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT-- 1300 Query: 376 EQWKLKEQQLK-VQIAQLETALKSDLTDKTEILDRLKTERDQN-----EKLVQENRELQL 429 L E + K +++A+ +L S L D E+L +T + N +L +E LQ Sbjct: 1301 --GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE-ETRQKLNVSTKLRQLEEERNSLQD 1357 Query: 430 QYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKN------GDLSFLVKV 483 Q E+ + L++ I N + + +L + ++A +E K +L+ + Sbjct: 1358 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1417 Query: 484 DSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQM---EVEAVTRKMENL 540 + LE++ LQ + V +L+ R ++ K + + E + ++ K + Sbjct: 1418 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADE 1477 Query: 541 QQDYELKV-EQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIH 599 + E + E+ L + A LEA+ +++ K K + E + S D+ + +H Sbjct: 1478 RDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDLV-SSKDDVGKNVH 1535 Query: 600 -LERGENLFEIHINKVTFSSEVLQ 622 LE+ + E + ++ E L+ Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELE 1559 Score = 70.9 bits (172), Expect = 7e-12 Identities = 121/601 (20%), Positives = 252/601 (41%), Gaps = 102/601 (16%) Query: 27 LQETSTTRTMKSRQAVSRVSR-EELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRL 85 LQ+T ++RQ ++ ++ +LE+ L D+ L + +++ + ++T I+L Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ---LDEEMEAKQNLERHISTLNIQL 1380 Query: 86 VNDKKRY-------ERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQ 138 + KK+ E + G KR + E+E + +Q +EK +K +T KNRL Sbjct: 1381 SDSKKKLQDFASTVEALEEGKKRFQK--EIENLTQQYEEKAAAYDKLEKT-KNRLQQELD 1437 Query: 139 QL--QTQGYRQTPYN----------------NVQSRINTGRRKANENAGLQECPRKGIK- 179 L RQ N N+ S+ R +A A +E + Sbjct: 1438 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1497 Query: 180 -----FQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRG---QIEELEHLAEI 231 + + E + M L+ +N+ + +S+R Q+EE++ E Sbjct: 1498 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1557 Query: 232 LKTQLRRKEN---EIELSL----------LQLREQQATDQRSNIRDNVEMIKLHKQLVEK 278 L+ +L+ E+ +E+++ LQ R++Q ++R ++ + + + K Sbjct: 1558 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1617 Query: 279 SNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFS- 337 AL+A K +L+ + L + D+ + +E QL++ + + +++L + S Sbjct: 1618 QRALAAAAKK--KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR 1675 Query: 338 ----------ERRIEELQDRINDLE----------KERELLKENYDKLYDSAFSAAHEEQ 377 E++ + L+ + L+ K+ +L KE + S+ S + Q Sbjct: 1676 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1735 Query: 378 WKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQE---NRELQLQYLEQ 434 + +++L+ +IAQLE L+ + + + DR++ Q E+L E R + Sbjct: 1736 DE--KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793 Query: 435 KQQLDELKK--RIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLE 492 +QQL+ K R KL+ E A K + ++ L +++ + +E Sbjct: 1794 RQQLERQNKELRSKLHEMEG---------------AVKSKFKSTIAALEAKIAQLEEQVE 1838 Query: 493 RSMRELQATHAETVQELEKTRNMLIM---QHKINKDYQMEVEAVTRKMENLQQDYELKVE 549 + RE QA Q+ +K + +L+ + K+ + Y+ + E +++ L++ E E Sbjct: 1839 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1898 Query: 550 Q 550 + Sbjct: 1899 E 1899 Score = 70.5 bits (171), Expect = 1e-11 Identities = 80/386 (20%), Positives = 177/386 (45%), Gaps = 45/386 (11%) Query: 214 VIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEM----- 268 ++Q R + E E+ KT+ R+++ E EL L+ + Q T++++ +++ ++ Sbjct: 851 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910 Query: 269 -------IKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQR 321 ++L + E L ME + + +++ + L+ + +L QL+E+ Sbjct: 911 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970 Query: 322 LKCCSLEKQLHSMKFSERRIEE----LQDRINDLEKERELLKENYDKLYDSAFSAAHEEQ 377 L+ + + + +++E+ + D+ N L KER+LL+E ++ D + A EE+ Sbjct: 971 AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE---RISDLTTNLAEEEE 1027 Query: 378 WKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQ 437 K K + +L+ +S ++ E+ RLK E ++L + R+L+ + +Q Sbjct: 1028 -KAKN------LTKLKNKHESMIS---ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077 Query: 438 LDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVD---SEINKDL--- 491 + +L+ +I + +EL AL + + QKN L + +++ S++ +DL Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137 Query: 492 -------ERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDY 544 E+ R+L ELE T + Q ++ + EV + + ++ + + Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197 Query: 545 ELKVEQYVHLLDIRAARIHKLEAQLK 570 E +V++ + A + +L QL+ Sbjct: 1198 EAQVQE---MRQKHAQAVEELTEQLE 1220 Score = 66.6 bits (161), Expect = 1e-10 Identities = 102/489 (20%), Positives = 206/489 (42%), Gaps = 83/489 (16%) Query: 39 RQAVSRVSREELEDRFLRLHDENILLKQ---------HARKQEDKIKRMATKLIRLVNDK 89 RQ VS + +++ + L ++NI K AR++E K +A L + K Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1506 Query: 90 KRYERVGGGPKRLGRDVEMEEMI---EQLQEKVHELEKQNETLKNRLISAKQQLQT--QG 144 + ER K EME+++ + + + VHELEK L+ ++ K QL+ Sbjct: 1507 EELERTNKMLK-----AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561 Query: 145 YRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEA 204 + T ++ +N K LQ Q+ + +Y L +E Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDE-----QNEEKRRQLQRQLHEYETELEDER 1616 Query: 205 R-------------GEIRNLE----NVIQSQRGQIEELEHLAEILKTQLRR--------- 238 + G++++LE + I+ + I++L L +K R Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1676 Query: 239 ------KENE-----IELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEG 287 KENE +E L+QL+E A +R+ + ++E +L ++L + +A++ Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD 1736 Query: 288 KFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDR 347 + +L+ + L + N + ++ ++++ + L +L + + + ++ E + + Sbjct: 1737 EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ 1796 Query: 348 INDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEIL 407 LE++ KE KL++ A + ++K L+ +IAQLE ++ + +K Sbjct: 1797 ---LERQN---KELRSKLHE--MEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1848 Query: 408 DRLKTERDQNEKL---VQENRELQLQYLEQ-----------KQQLDELKKRIKLYNQEND 453 LK + + +++ V++ R++ QY EQ K+QL+E ++ + N Sbjct: 1849 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1908 Query: 454 INADELSEA 462 EL EA Sbjct: 1909 KLQRELDEA 1917 >gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo sapiens] Length = 1938 Score = 80.9 bits (198), Expect = 7e-15 Identities = 121/605 (20%), Positives = 247/605 (40%), Gaps = 76/605 (12%) Query: 29 ETSTTRTMKSRQAVSRVSRE------ELEDRFLRLHDENILLKQHARKQEDKIK----RM 78 E + KSRQ + ++ R+ + ++ L + LK K+E++++ R+ Sbjct: 1040 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1099 Query: 79 ATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKV-----HELEKQNETLKNRL 133 ++ + N K+ + G L D++ E EK ELE L++ L Sbjct: 1100 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL 1159 Query: 134 ISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMF 193 S Q + + R+ ++ ++ R + A +QE +K H Sbjct: 1160 DSTATQQELRAKREQEVTVLKKALDEETR--SHEAQVQEMRQK-------------HAQA 1204 Query: 194 TKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEIL---KTQLRRKENEIELSLLQL 250 + LE+ + NL+ Q+ + +L +L K ++ K+ ++E + +L Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264 Query: 251 REQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFI-----------QLQEKQRTL 299 + + + +R+ N ++ KL ++ + L+ EGK I QLQ+ Q L Sbjct: 1265 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1324 Query: 300 RISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKER---- 355 + + +L +E+ L++++ + + ER I L +++D +K+ Sbjct: 1325 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1384 Query: 356 ---ELLKENYDKLYDSAFSAAHEEQWKL----KEQQLKVQIAQLETALKSDLTDKTEILD 408 E L+E + + + + K K ++ K ++ Q L DL ++ +++ Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444 Query: 409 RLKTERDQNEKLVQENRELQLQYLEQKQQLD------ELKKRIKLYNQENDINA-DELSE 461 L+ ++ + ++L+ E + + +Y +++ + + E K E + A +EL Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1504 Query: 462 ALLLIKAQKEQKNGDLSFLVKVDSEINKD---LERSMRELQATHAETVQELEKTR----- 513 ++KA+ E + K E+ K LE M E++ E EL+ T Sbjct: 1505 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1564 Query: 514 ---NMLIMQHKINKDYQMEVEAVTRKMENLQQ---DYELKVEQYVHLLDIRAARIHKLEA 567 NM ++ + +D Q E K LQ+ +YE ++E + AA KLE Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1624 Query: 568 QLKDI 572 LKD+ Sbjct: 1625 DLKDL 1629 Score = 78.6 bits (192), Expect = 3e-14 Identities = 130/606 (21%), Positives = 252/606 (41%), Gaps = 68/606 (11%) Query: 37 KSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVG 96 K RQ + +ELE + +L +E LL++ + + + +RL K+ E + Sbjct: 865 KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL 924 Query: 97 GGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSR 156 EME +E+ +++ +L+ + + + +++ ++QL+ + + + Sbjct: 925 H---------EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 975 Query: 157 INTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQ 216 +K + + + + + + E + T L E + +NL + Sbjct: 976 AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN-----LAEEEEKAKNLTKLKN 1030 Query: 217 SQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRD-NVEMIKLHKQL 275 I ELE + K + R+E E L + E A+D I D ++ +L QL Sbjct: 1031 KHESMISELE--VRLKKEEKSRQELE---KLKRKLEGDASDFHEQIADLQAQIAELKMQL 1085 Query: 276 VEKSNALSAMEGKF-IQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSM 334 +K L A + ++ +K L+ + L + +L L +R EKQ + Sbjct: 1086 AKKEEELQAALARLDDEIAQKNNALKKIRE-LEGHISDLQEDLDSERAARNKAEKQKRDL 1144 Query: 335 -KFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLE 393 + E EL+D ++ ++EL + ++ + A +E+ + E Q++ ++ Q Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEV--TVLKKALDEETRSHEAQVQ-EMRQKH 1201 Query: 394 TALKSDLTDKTEILDRLKTERDQNEK-LVQENREL--QLQYLEQ-KQQLDELKKRIKLYN 449 +LT++ E R K D+N++ L +EN +L +L+ L Q KQ+++ KK+++ Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1261 Query: 450 QENDINAD-------ELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATH 502 QE EL++ + ++ + E G L+ ++ KD+ +LQ T Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321 Query: 503 AETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARI 562 E +Q E+TR L + K+ Q+E E R Q D E++ +Q + I Sbjct: 1322 -ELLQ--EETRQKLNVSTKLR---QLEEE---RNSLQDQLDEEMEAKQNLE------RHI 1366 Query: 563 HKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIH-LERGENLFEIHINKVTFSSEVL 621 L QL D + +F T+ LE G+ F+ I +T E Sbjct: 1367 STLNIQLSD---------------SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEK 1411 Query: 622 QASGDK 627 A+ DK Sbjct: 1412 AAAYDK 1417 Score = 75.9 bits (185), Expect = 2e-13 Identities = 125/557 (22%), Positives = 229/557 (41%), Gaps = 79/557 (14%) Query: 48 EELEDRFLRLHDENILLKQHARKQEDKIKRM--ATKLIRLVNDKKRYERVGGGPKRLGRD 105 EELE L D L A +QE + KR T L + ++++ R R Sbjct: 1146 EELEALKTELEDT---LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1202 Query: 106 VEMEEMIEQLQEKVH---ELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRR 162 +EE+ EQL++ L+K +TL+ +L+ G Q++ + Sbjct: 1203 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG---------QAKQEVEHK 1253 Query: 163 KANENAGLQECPRKGIKFQDA--DVAETPHPMFTKYGN--SLLEEARGEIRNLENVIQSQ 218 K A +QE K + A ++ + H + + + +L EA G+ L + S Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313 Query: 219 RGQIEELEHLAEILKTQLRRKENEIELSLLQLRE-----QQATDQRSNIRDNVEM----- 268 Q+++ + E+L+ + R+K N + L QL E Q D+ + N+E Sbjct: 1314 SSQLQDTQ---ELLQEETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369 Query: 269 -IKLH---KQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKC 324 I+L K+L + ++ + A+E + Q++ L ++ A D+L + + Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1429 Query: 325 CSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWK----- 379 L L + + +E+ Q + + L E + + Y D A + A E++ K Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1489 Query: 380 --LKEQ-QLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQ 436 L+E + K ++ + LK+++ D D + + EK R L+ Q E K Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK---SKRALETQMEEMKT 1546 Query: 437 QLDELKKRIKLYNQENDINADELSEALLLIKAQ--KEQKNGDLSFLVKVDSEINKDLERS 494 QL+EL E+++ A E ++ L + Q K Q DL + + E + L+R Sbjct: 1547 QLEEL---------EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1597 Query: 495 MRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHL 554 + E + ELE R + A +K+E +D EL+ + + Sbjct: 1598 LHEYET-------ELEDERKQRAL-----------AAAAKKKLEGDLKDLELQADSAIKG 1639 Query: 555 LDIRAARIHKLEAQLKD 571 + ++ KL+AQ+KD Sbjct: 1640 REEAIKQLRKLQAQMKD 1656 Score = 74.3 bits (181), Expect = 7e-13 Identities = 127/624 (20%), Positives = 256/624 (41%), Gaps = 61/624 (9%) Query: 28 QETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVN 87 +E + + ++ + + ++LED L + D+N L + + E++I + T L Sbjct: 961 EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020 Query: 88 DKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQ 147 K ++ K E+E +++ ++ ELEK L+ +Q+ Sbjct: 1021 KAKNLTKLKN--KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA------ 1072 Query: 148 TPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGE 207 ++Q++I + + A +E + + D ++A+ + + + E G Sbjct: 1073 ----DLQAQIAELKMQL---AKKEEELQAALARLDDEIAQKNNAL------KKIRELEGH 1119 Query: 208 IRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVE 267 I +L+ + S+R + E L +L + E+E +L + AT Q + E Sbjct: 1120 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL----DSTATQQELRAKREQE 1175 Query: 268 MIKLHKQLVEKSNALSA----MEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQ--- 320 + L K L E++ + A M K Q E+ AN D+ L+++ Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1235 Query: 321 ---RLKCCSLEKQ--LHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHE 375 L+ KQ H K E +++ELQ + +D E+ R L + KL + S Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT-- 1293 Query: 376 EQWKLKEQQLK-VQIAQLETALKSDLTDKTEILDRLKTERDQN-----EKLVQENRELQL 429 L E + K +++A+ +L S L D E+L +T + N +L +E LQ Sbjct: 1294 --GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE-ETRQKLNVSTKLRQLEEERNSLQD 1350 Query: 430 QYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKN------GDLSFLVKV 483 Q E+ + L++ I N + + +L + ++A +E K +L+ + Sbjct: 1351 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1410 Query: 484 DSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQM---EVEAVTRKMENL 540 + LE++ LQ + V +L+ R ++ K + + E + ++ K + Sbjct: 1411 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADE 1470 Query: 541 QQDYELKV-EQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIH 599 + E + E+ L + A LEA+ +++ K K + E + S D+ + +H Sbjct: 1471 RDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDLV-SSKDDVGKNVH 1528 Query: 600 -LERGENLFEIHINKVTFSSEVLQ 622 LE+ + E + ++ E L+ Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELE 1552 Score = 70.9 bits (172), Expect = 7e-12 Identities = 121/601 (20%), Positives = 252/601 (41%), Gaps = 102/601 (16%) Query: 27 LQETSTTRTMKSRQAVSRVSR-EELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRL 85 LQ+T ++RQ ++ ++ +LE+ L D+ L + +++ + ++T I+L Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ---LDEEMEAKQNLERHISTLNIQL 1373 Query: 86 VNDKKRY-------ERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQ 138 + KK+ E + G KR + E+E + +Q +EK +K +T KNRL Sbjct: 1374 SDSKKKLQDFASTVEALEEGKKRFQK--EIENLTQQYEEKAAAYDKLEKT-KNRLQQELD 1430 Query: 139 QL--QTQGYRQTPYN----------------NVQSRINTGRRKANENAGLQECPRKGIK- 179 L RQ N N+ S+ R +A A +E + Sbjct: 1431 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1490 Query: 180 -----FQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRG---QIEELEHLAEI 231 + + E + M L+ +N+ + +S+R Q+EE++ E Sbjct: 1491 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1550 Query: 232 LKTQLRRKEN---EIELSL----------LQLREQQATDQRSNIRDNVEMIKLHKQLVEK 278 L+ +L+ E+ +E+++ LQ R++Q ++R ++ + + + K Sbjct: 1551 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1610 Query: 279 SNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFS- 337 AL+A K +L+ + L + D+ + +E QL++ + + +++L + S Sbjct: 1611 QRALAAAAKK--KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR 1668 Query: 338 ----------ERRIEELQDRINDLE----------KERELLKENYDKLYDSAFSAAHEEQ 377 E++ + L+ + L+ K+ +L KE + S+ S + Q Sbjct: 1669 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1728 Query: 378 WKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQE---NRELQLQYLEQ 434 + +++L+ +IAQLE L+ + + + DR++ Q E+L E R + Sbjct: 1729 DE--KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786 Query: 435 KQQLDELKK--RIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLE 492 +QQL+ K R KL+ E A K + ++ L +++ + +E Sbjct: 1787 RQQLERQNKELRSKLHEMEG---------------AVKSKFKSTIAALEAKIAQLEEQVE 1831 Query: 493 RSMRELQATHAETVQELEKTRNMLIM---QHKINKDYQMEVEAVTRKMENLQQDYELKVE 549 + RE QA Q+ +K + +L+ + K+ + Y+ + E +++ L++ E E Sbjct: 1832 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1891 Query: 550 Q 550 + Sbjct: 1892 E 1892 Score = 70.5 bits (171), Expect = 1e-11 Identities = 80/386 (20%), Positives = 177/386 (45%), Gaps = 45/386 (11%) Query: 214 VIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEM----- 268 ++Q R + E E+ KT+ R+++ E EL L+ + Q T++++ +++ ++ Sbjct: 844 LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903 Query: 269 -------IKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQR 321 ++L + E L ME + + +++ + L+ + +L QL+E+ Sbjct: 904 AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963 Query: 322 LKCCSLEKQLHSMKFSERRIEE----LQDRINDLEKERELLKENYDKLYDSAFSAAHEEQ 377 L+ + + + +++E+ + D+ N L KER+LL+E ++ D + A EE+ Sbjct: 964 AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE---RISDLTTNLAEEEE 1020 Query: 378 WKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQ 437 K K + +L+ +S ++ E+ RLK E ++L + R+L+ + +Q Sbjct: 1021 -KAKN------LTKLKNKHESMIS---ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070 Query: 438 LDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVD---SEINKDL--- 491 + +L+ +I + +EL AL + + QKN L + +++ S++ +DL Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130 Query: 492 -------ERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDY 544 E+ R+L ELE T + Q ++ + EV + + ++ + + Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190 Query: 545 ELKVEQYVHLLDIRAARIHKLEAQLK 570 E +V++ + A + +L QL+ Sbjct: 1191 EAQVQE---MRQKHAQAVEELTEQLE 1213 Score = 66.6 bits (161), Expect = 1e-10 Identities = 102/489 (20%), Positives = 206/489 (42%), Gaps = 83/489 (16%) Query: 39 RQAVSRVSREELEDRFLRLHDENILLKQ---------HARKQEDKIKRMATKLIRLVNDK 89 RQ VS + +++ + L ++NI K AR++E K +A L + K Sbjct: 1440 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1499 Query: 90 KRYERVGGGPKRLGRDVEMEEMI---EQLQEKVHELEKQNETLKNRLISAKQQLQT--QG 144 + ER K EME+++ + + + VHELEK L+ ++ K QL+ Sbjct: 1500 EELERTNKMLK-----AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554 Query: 145 YRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEA 204 + T ++ +N K LQ Q+ + +Y L +E Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDE-----QNEEKRRQLQRQLHEYETELEDER 1609 Query: 205 R-------------GEIRNLE----NVIQSQRGQIEELEHLAEILKTQLRR--------- 238 + G++++LE + I+ + I++L L +K R Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1669 Query: 239 ------KENE-----IELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEG 287 KENE +E L+QL+E A +R+ + ++E +L ++L + +A++ Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD 1729 Query: 288 KFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDR 347 + +L+ + L + N + ++ ++++ + L +L + + + ++ E + + Sbjct: 1730 EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ 1789 Query: 348 INDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEIL 407 LE++ KE KL++ A + ++K L+ +IAQLE ++ + +K Sbjct: 1790 ---LERQN---KELRSKLHE--MEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1841 Query: 408 DRLKTERDQNEKL---VQENRELQLQYLEQ-----------KQQLDELKKRIKLYNQEND 453 LK + + +++ V++ R++ QY EQ K+QL+E ++ + N Sbjct: 1842 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1901 Query: 454 INADELSEA 462 EL EA Sbjct: 1902 KLQRELDEA 1910 >gi|31982906 cingulin-like 1 [Homo sapiens] Length = 1302 Score = 80.5 bits (197), Expect = 9e-15 Identities = 108/549 (19%), Positives = 243/549 (44%), Gaps = 57/549 (10%) Query: 29 ETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVND 88 E + +K + R + EEL + +EN L+Q + E ++++ +L ++ + Sbjct: 633 EVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKME 692 Query: 89 KKRYERVGGGPKRLGRDV--EMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYR 146 +++++ RD+ ++ EM ++L +++ L L+ AKQ LQ Sbjct: 693 REQHQTE-------IRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIA 745 Query: 147 QTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARG 206 + ++ R++ E L+ ++ + D ++ + + +L E Sbjct: 746 KEEQEDLL------RKRERELTALKGALKEEVSSHDQEMDKLKE-QYDAELQALRESVEE 798 Query: 207 EIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNV 266 +N+E + + R E + ++ +L ++ENE LQ R ++ + + ++ + Sbjct: 799 ATKNVE--VLASRSNTSEQDQAGTEMRVKLLQEENE----KLQGRSEELERRVAQLQRQI 852 Query: 267 EMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCS 326 E +K + + L EG+ QL+E AL+ E + +R + Sbjct: 853 EDLKGDE--AKAKETLKKYEGEIRQLEE----------ALVHARKEEKEAVSARR----A 896 Query: 327 LEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLK 386 LE +L + + + + + Q ++++ KE KE +L + E+W L + K Sbjct: 897 LENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNE----MENERWHLGKTIEK 952 Query: 387 VQIAQLETALKSDLTDKTEILDRLKTERDQNEK-LVQENRELQLQYLE-QKQQLDELKKR 444 +Q ++ +++ T E+ ++L +++N + L + R+L+ + LE +K +L +K + Sbjct: 953 LQ-KEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQ 1011 Query: 445 IKLYNQENDINADELSEALLLIKAQ-KEQKNGDLSFLVKVDSEINKDLERSMRELQATHA 503 ++ E ++ + ++ L K Q EQ DL + ++ S + D R +++++ + Sbjct: 1012 DEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVS 1071 Query: 504 ETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIH 563 + ELE+ RN N D + E ++R E ++Q +++ D+ +I Sbjct: 1072 QLEMELEEERN--------NSD--LLSERISRSREQMEQLRNELLQERAARQDLECDKI- 1120 Query: 564 KLEAQLKDI 572 LE Q KD+ Sbjct: 1121 SLERQNKDL 1129 Score = 75.9 bits (185), Expect = 2e-13 Identities = 115/584 (19%), Positives = 244/584 (41%), Gaps = 82/584 (14%) Query: 47 REELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDV 106 RE +E+ + E + + + +Q+ M KL++ N+K + GR Sbjct: 793 RESVEEATKNV--EVLASRSNTSEQDQAGTEMRVKLLQEENEKLQ-----------GRSE 839 Query: 107 EMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANE 166 E+E + QLQ ++ +L+ K L + +++ ++ + R++ E Sbjct: 840 ELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIR----------QLEEALVHARKEEKE 889 Query: 167 NAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEA--RGEIRNLENVIQSQRGQIEE 224 + ++ ++++T + L EE+ + ++R L+N ++++R Sbjct: 890 AVSARRALENELEAAQGNLSQTTQEQ-KQLSEKLKEESEQKEQLRRLKNEMENERW---- 944 Query: 225 LEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSA 284 HL + ++ + + +E S E Q ++ E+ ++ +QL EK+ Sbjct: 945 --HLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEK 1002 Query: 285 MEGKFIQLQEKQRTLRIS-HDALMANGDELNM-QLKEQRLKCCS--LEKQLHSMKFSERR 340 +++Q++ R + D A + L QL EQ LK LE + H R Sbjct: 1003 SRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRL 1062 Query: 341 IEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDL 400 +++++D+++ LE E E + N D L S + E+ +L+ + L+ E A + DL Sbjct: 1063 VKQMEDKVSQLEMELEEERNNSD-LLSERISRSREQMEQLRNELLQ------ERAARQDL 1115 Query: 401 TDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELS 460 D++ ER QN+ L L+ Y K+ L ++ ++ E+ + ++E Sbjct: 1116 E-----CDKISLER-QNKDLKSRIIHLEGSYRSSKEGL-VVQMEARIAELEDRLESEERD 1168 Query: 461 EALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQH 520 A L + N+ LER ++EL + L ++ L ++ Sbjct: 1169 RANLQLS--------------------NRRLERKVKELVMQVDDEHLSLTDQKDQLSLRL 1208 Query: 521 KINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYK 580 K K E E ++E+ ++ + ++E+ + + + +++ ++ L+ K Sbjct: 1209 KAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLR--------LK 1260 Query: 581 FKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSEVLQAS 624 P + DD D+ D + G +L+E ++ TFS + AS Sbjct: 1261 KLPSKVLDDMDDDDDLSTD---GGSLYEAPVS-YTFSKDSTVAS 1300 Score = 62.8 bits (151), Expect = 2e-09 Identities = 120/580 (20%), Positives = 234/580 (40%), Gaps = 132/580 (22%) Query: 31 STTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKK 90 +T +K +Q +++ + EE + L + LK+ + +D KR + + K Sbjct: 535 ATPDLLKGQQELTQQTNEETAKQILYNY-----LKEGSTDNDDATKRKVNLVFEKIQTLK 589 Query: 91 RYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRL-ISAKQQLQTQGYRQTP 149 R G + + ++ L E+ +L + L+ +L + K Q + R+ Sbjct: 590 --SRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERM 647 Query: 150 YNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIR 209 N++ + K EN+ LQ+ LEE+ GE+R Sbjct: 648 RANLEELRSQHNEKVEENSTLQQ---------------------------RLEESEGELR 680 Query: 210 NLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMI 269 ++L E+ + ++ R++++ E+ LQ DQ S + D ++ Sbjct: 681 ----------------KNLEELFQVKMEREQHQTEIRDLQ-------DQLSEMHDELDSA 717 Query: 270 KLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEK 329 K + EK + + LQ KQ D L+A ++ ++ K +R Sbjct: 718 KRSEDR-EKGALIEEL------LQAKQDL----QDLLIAKEEQEDLLRKRER-------- 758 Query: 330 QLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQI 389 +L ++K + L++ ++ ++E + LKE YD + A E ++E V++ Sbjct: 759 ELTALKGA------LKEEVSSHDQEMDKLKEQYD----AELQALRES---VEEATKNVEV 805 Query: 390 AQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQL-----DELKKR 444 + TE+ R+K +++NEKL + EL+ + + ++Q+ DE K + Sbjct: 806 LASRSNTSEQDQAGTEM--RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAK 863 Query: 445 IKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAE 504 L E +I +L EA L+ A+KE+K V + +LE + L T E Sbjct: 864 ETLKKYEGEIR--QLEEA--LVHARKEEKEA-----VSARRALENELEAAQGNLSQTTQE 914 Query: 505 TVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHK 564 Q EK + + E + R+++N E++ E++ HL I K Sbjct: 915 QKQLSEKLKE------------ESEQKEQLRRLKN-----EMENERW-HL----GKTIEK 952 Query: 565 LEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGE 604 L+ ++ DI ++ + + + +DE+ E E E Sbjct: 953 LQKEMADIVEASRTSTLELQ----NQLDEYKEKNRRELAE 988 >gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens] Length = 1088 Score = 80.1 bits (196), Expect = 1e-14 Identities = 123/601 (20%), Positives = 254/601 (42%), Gaps = 107/601 (17%) Query: 39 RQAVSRVSREELEDRFLRLHDENILLKQHA-RKQEDKIKRMATKLIRLVNDKK--RYERV 95 R A + + LE + EN +L++ R+ E+ TK ++ V + K + + Sbjct: 335 RLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSM 394 Query: 96 GGGPKRLGRDVEMEEM-----IEQLQEKVHELE---KQNETLKNRLISAKQQLQTQGYRQ 147 G + L +++M + E+ +E++ ++E ++ +KN++ KQ+L + Sbjct: 395 ERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSR---KD 451 Query: 148 TPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVA----------------ETPHP 191 T +Q+++ T + +++ E ++ + ++ A ET Sbjct: 452 TELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLN 511 Query: 192 MFTKYGNSLLEEA---RGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEI----- 243 TK + EE GEI +L++++ + ++ L+ E L+ QLR KE ++ Sbjct: 512 KKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKE 571 Query: 244 --------------------------ELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVE 277 E ++ +L+EQ+ D+R + K K L E Sbjct: 572 RVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKE 631 Query: 278 KSNAL----SAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQL-- 331 K + L S E + L+E +L S + L + L++++ +C +E QL Sbjct: 632 KVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKK 691 Query: 332 -HSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIA 390 H R E+ DRI LE+E K+ K A E +L E +V+ Sbjct: 692 AHEAALEARASPEMSDRIQHLEREITRYKDESSK--------AQAEVDRLLEILKEVE-- 741 Query: 391 QLETALKSDLTDKTEILDRLKTE-RDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYN 449 ++ DK + + L+ + +DQN+K+ + Q++ + Q L+E ++R Sbjct: 742 -------NEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRR----- 789 Query: 450 QENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQEL 509 + N ++ S+ L +K+ + +L ++ +I + E + + ++ +++ Sbjct: 790 ---EDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQV 846 Query: 510 EKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQL 569 E+ +L+ K+ + E+E++ K+ + QQ E+ HL ++RA R LE L Sbjct: 847 EE---LLMAMEKV----KQELESMKAKLSSTQQSL---AEKETHLTNLRAERRKHLEEVL 896 Query: 570 K 570 + Sbjct: 897 E 897 Score = 47.0 bits (110), Expect = 1e-04 Identities = 98/547 (17%), Positives = 218/547 (39%), Gaps = 60/547 (10%) Query: 1 MSGPTDETAGDLPVKDTGLNLFGMGGLQETSTTRTMKSRQAVSRVSREEL---EDRFLRL 57 M + +L KDT L + ET T + S+Q + V +E L E R L Sbjct: 436 MKNKIGQVKQELSRKDT--ELLALQTKLETLTNQFSDSKQHIE-VLKESLTAKEQRAAIL 492 Query: 58 HDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQE 117 E L+ ++E + + ++ + +K + G ++++M++ + Sbjct: 493 QTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGT---------QAGEIHDLKDMLDVKER 543 Query: 118 KVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKG 177 KV+ L+K+ E L+ +L ++Q+ + R + +T E +E + Sbjct: 544 KVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIER 603 Query: 178 IKFQ-DADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEEL-EHLAEILKTQ 235 +K Q D D E + Y L ++ + ++ L+ + + + +L EH + + + Sbjct: 604 LKEQRDRDEREKQEEI-DNYKKDL-KDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSG 661 Query: 236 LRRKENEIELSL-LQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQE 294 L++ L + L+ ++++ S ++ E + E S+ + +E + + ++ Sbjct: 662 LKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKD 721 Query: 295 KQ--------RTLRISHDALMANGD------ELNMQLKEQRLKCCSLE-KQLHSMKFSER 339 + R L I + D EL Q+K+Q K +L+ K+ K S + Sbjct: 722 ESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQ 781 Query: 340 RIEEL---QDRIND---------------LEKERELLKENYDKLYDSAFSAAHEEQWKLK 381 +EE +D +ND +E+ E L+E+ + A EE + Sbjct: 782 MLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTN 841 Query: 382 EQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDEL 441 ++ ++ +K +L L + + E + R + ++LE + L+ Sbjct: 842 AEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLE--EVLEMK 899 Query: 442 KKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQAT 501 ++ + E D N ALL + + K++ +++ L + + + L++ + Sbjct: 900 QEALLAAISEKDANI-----ALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKL 954 Query: 502 HAETVQE 508 A+ ++ Sbjct: 955 MADNYED 961 Score = 41.6 bits (96), Expect = 0.005 Identities = 82/427 (19%), Positives = 178/427 (41%), Gaps = 74/427 (17%) Query: 175 RKGIKFQDADVAETPHPMFTKYGNSLLEEA---RGEIRNLENVIQSQRGQIEELEHLAEI 231 RK ++ +++ ++ + + + T + L +E + E + + R EE +H+ Sbjct: 169 RKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQ-- 226 Query: 232 LKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQ 291 + Q + E I+ L QL +Q ++ R+ E+ + + Q + + A E ++ Sbjct: 227 MTIQALQDELRIQRDLNQLFQQDSSS-RTGEPCVAELTEENFQRLHAEHERQAKELFLLR 285 Query: 292 --LQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLE------KQLHSMKFSERRIEE 343 L+E + + L A + + L+ + K S + ++ + +E + Sbjct: 286 KTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHH 345 Query: 344 LQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDK 403 L+ + EKE +L+E + +++A +A + + + +I+ +E L+ DL ++ Sbjct: 346 LESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLR-DLEEE 404 Query: 404 TEIL---DRLKTERDQNE----------------KLVQENRELQL--------------- 429 ++L L TE + E K+ Q +EL Sbjct: 405 IQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETL 464 Query: 430 --QYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEI 487 Q+ + KQ ++ LK+ + Q I E+ +AL L +KE + L K +I Sbjct: 465 TNQFSDSKQHIEVLKESLTAKEQRAAILQTEV-DALRLRLEEKE------TMLNKKTKQI 517 Query: 488 NKDLERSMRELQATHAETVQELE-----KTRNMLIMQHKIN------KDYQMEVEAVTRK 536 + M E + T A + +L+ K R + ++Q KI +D + ++ ++ + Sbjct: 518 -----QDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKER 572 Query: 537 MENLQQD 543 +++LQ D Sbjct: 573 VKSLQAD 579 >gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens] Length = 1960 Score = 79.7 bits (195), Expect = 2e-14 Identities = 119/562 (21%), Positives = 229/562 (40%), Gaps = 69/562 (12%) Query: 28 QETSTTRTMKSRQAVSRVSREELEDRFLRLHDENIL---LKQHARKQEDKIKRMATKLIR 84 +E +T S +++EL + R + NIL L++ A+ E +I+ M K + Sbjct: 1139 EELEALKTELEDTLDSTAAQQELRSK--REQEVNILKKTLEEEAKTHEAQIQEMRQKHSQ 1196 Query: 85 LVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNR----LISAKQQL 140 V E+ E +EQ + LEK +TL+N K L Sbjct: 1197 AVE-------------------ELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLL 1237 Query: 141 QTQGYRQTPYNNVQSRINTGRRKANENAGLQ-ECPRKGIKFQDADVAETPHPMFTKYGNS 199 Q +G + V++++ + K NE ++ E K K Q V +S Sbjct: 1238 QGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQ---VELDNVTGLLSQSDS 1294 Query: 200 LLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQR 259 + + LE+ +Q + ++E L T+L++ E+E QL E++ + + Sbjct: 1295 KSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEE--EAK 1352 Query: 260 SNIRDNV-----EMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELN 314 N+ + ++ + K++ + L E +LQ+ L H+ +A D+L Sbjct: 1353 HNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLE 1412 Query: 315 MQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAH 374 + + L L + S +E+ Q + + L E + + Y + D A + A Sbjct: 1413 KTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAR 1472 Query: 375 EEQWKLKE-----QQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQL 429 E++ K ++ Q A+LE K +TE+ D + ++ D + + EL+ Sbjct: 1473 EKETKALSLARALEEAMEQKAELERLNKQF---RTEMEDLMSSKDDVGKSV----HELEK 1525 Query: 430 QYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINK 489 +QQ++E+K +++ E D + ++A K Q DL + E K Sbjct: 1526 SKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKK 1585 Query: 490 DLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVE 549 L R +RE++A ELE R M K +M+++ + +++ ++ + ++ Sbjct: 1586 QLVRQVREMEA-------ELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIK 1638 Query: 550 QYVHLLDIRAARIHKLEAQLKD 571 Q + KL+AQ+KD Sbjct: 1639 Q-----------LRKLQAQMKD 1649 Score = 79.3 bits (194), Expect = 2e-14 Identities = 99/454 (21%), Positives = 202/454 (44%), Gaps = 56/454 (12%) Query: 192 MFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLR 251 +FTK LL+ +R E + + + ++ E + AE T++ ++++ LQL+ Sbjct: 830 LFTKV-KPLLQVSRQEEEMMAK--EEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQ 886 Query: 252 EQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGD 311 EQ + +L + E +E + + +E+ + L+ + N Sbjct: 887 EQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ 946 Query: 312 ELNMQLKEQRLKCCSLEKQLHSMKFSERRIEE----LQDRINDLEKERELLKENYDKLYD 367 EL QL+E+ L+ + + + +++EE L+D+ L KE++LL+ D++ + Sbjct: 947 ELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLE---DRIAE 1003 Query: 368 SAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENREL 427 + EE+ K + L A+L+ ++ +TD E RL+ E Q ++L + R+L Sbjct: 1004 FTTNLTEEEE---KSKSL----AKLKNKHEAMITDLEE---RLRREEKQRQELEKTRRKL 1053 Query: 428 QLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVD--- 484 + + Q+ EL+ +I + +EL AL ++ + QKN L + +++ Sbjct: 1054 EGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQI 1113 Query: 485 SEINKDL----------ERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVT 534 SE+ +DL E+ R+L ELE T + Q ++ + EV + Sbjct: 1114 SELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILK 1173 Query: 535 RKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEF 594 + +E + +E ++++ + + + +L QL+ TK+ K ++++ Sbjct: 1174 KTLEEEAKTHEAQIQE---MRQKHSQAVEELAEQLEQ----TKRVK--------ANLEKA 1218 Query: 595 DETIHLERGENLFEIHINKVTFSSEVLQASGDKE 628 +T+ ERGE E+ + +LQ GD E Sbjct: 1219 KQTLENERGELANEVKV--------LLQGKGDSE 1244 Score = 74.3 bits (181), Expect = 7e-13 Identities = 117/628 (18%), Positives = 254/628 (40%), Gaps = 69/628 (10%) Query: 28 QETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVN 87 +E S + ++ + + ++LE+ + L D+N L + + ED+I T L Sbjct: 954 EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEE 1013 Query: 88 DKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQ---LQTQ- 143 K ++ K ++EE + + +++ ELEK L+ Q LQ Q Sbjct: 1014 KSKSLAKLKN--KHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071 Query: 144 GYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEE 203 + + + + E A + K I+ ++ ++E + ++ + + Sbjct: 1072 AELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASR--NK 1129 Query: 204 ARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIR 263 A + R+L +++ + ++E+ + ++E E+ + L + E++A + I+ Sbjct: 1130 AEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNI-LKKTLEEEAKTHEAQIQ 1188 Query: 264 DNVEMIKLHKQLVEK-SNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRL 322 EM + H Q VE+ + L + L++ ++TL L AN ++ +Q K Sbjct: 1189 ---EMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGEL-ANEVKVLLQGKGD-- 1242 Query: 323 KCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKE 382 H K E +++ELQ + N+ E+ R L + KL Sbjct: 1243 -------SEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKL----------------- 1278 Query: 383 QQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELK 442 Q + L + S + T+ L+++ ++L+QE +L + +Q+++ K Sbjct: 1279 QVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEK 1338 Query: 443 KRIKLYNQENDINADELSEALLLIKAQ---KEQKNGDLSFLVKVDSEINKDLERSMRELQ 499 + +E + L + + + AQ ++K D ++ E+ + L++ + L Sbjct: 1339 NSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLS 1398 Query: 500 ATHAETV---QELEKTRNMLIMQHK---INKDYQME----VEAVTRKMENLQQDYELKVE 549 H E V +LEKT+ L + ++ D+Q + +E +K + L + + Sbjct: 1399 QRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISA 1458 Query: 550 QYVHLLDIRAARIHKLEAQLKDIAYG--------------TKQYKFKPEIMPDDSVDEFD 595 +Y D A + E + +A KQ++ + E + S D+ Sbjct: 1459 KYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLM-SSKDDVG 1517 Query: 596 ETIH-LERGENLFEIHINKVTFSSEVLQ 622 +++H LE+ + E + ++ E L+ Sbjct: 1518 KSVHELEKSKRALEQQVEEMKTQLEELE 1545 Score = 72.4 bits (176), Expect = 3e-12 Identities = 105/483 (21%), Positives = 196/483 (40%), Gaps = 89/483 (18%) Query: 109 EEMIEQLQEKVHELEKQ---------NETLKNRLISAKQQLQTQGYRQTPYNNVQSRINT 159 EEM+ + +E V EKQ ETL+++L++ K QLQ Q +T Sbjct: 845 EEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAET----------- 893 Query: 160 GRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQR 219 + C L + + LE + Sbjct: 894 -----------ELCAE---------------------AEELRARLTAKKQELEEICHDLE 921 Query: 220 GQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKS 279 ++EE E + L+ + ++ + I+ QL E+++ Q KL + V Sbjct: 922 ARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQ-----------KLQLEKVTTE 970 Query: 280 NALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSER 339 L +E + I L+++ L L E L E+ K SL K + E Sbjct: 971 AKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNK---HEA 1027 Query: 340 RIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSD 399 I +L++R+ EK+R+ L++ KL + + + +L+ QIA+L+ L Sbjct: 1028 MITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQ------IAELQAQIAELKMQLAKK 1081 Query: 400 LTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLD-ELKKRIKLYNQENDINAD- 457 + L R++ E Q +++ REL+ Q E ++ L+ E R K Q+ D+ + Sbjct: 1082 EEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEEL 1141 Query: 458 -----ELSEALLLIKAQKE---QKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQEL 509 EL + L AQ+E ++ +++ L K E K E ++E++ H++ V+EL Sbjct: 1142 EALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEEL 1201 Query: 510 EKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQL 569 + Q + K + +E + +EN + + +V+ + + K+EAQL Sbjct: 1202 AE-------QLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQL 1254 Query: 570 KDI 572 +++ Sbjct: 1255 QEL 1257 Score = 69.3 bits (168), Expect = 2e-11 Identities = 129/623 (20%), Positives = 270/623 (43%), Gaps = 108/623 (17%) Query: 27 LQETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKI----KRMATKL 82 LQ+T ++RQ +S L + ++ DE ++ ++E+ K++AT Sbjct: 1310 LQDTQELLQEENRQKLS------LSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLH 1363 Query: 83 IRLVNDKKRYERVGGG-------PKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLIS 135 ++ + KK+ E G ++L +D +E + ++ +EKV +K +T K RL Sbjct: 1364 AQVADMKKKMEDSVGCLETAEEVKRKLQKD--LEGLSQRHEEKVAAYDKLEKT-KTRLQQ 1420 Query: 136 AKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKF-QDADVAETPHPMFT 194 L Q QS N +++ + L E K+ ++ D AE Sbjct: 1421 ELDDLLVDLDHQR-----QSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKE 1475 Query: 195 KYGNSL---LEEARGEIRNLENVIQSQRGQIEEL---------------------EHLAE 230 SL LEEA + LE + + R ++E+L E E Sbjct: 1476 TKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVE 1535 Query: 231 ILKTQLRRKENEI----------ELSL----------LQLREQQATDQRSNIRDNVEMIK 270 +KTQL E+E+ E++L LQ R++Q+ +++ + V ++ Sbjct: 1536 EMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREME 1595 Query: 271 LHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLK--EQRLKCC--- 325 + K +++ K +++ K I D+ N DE QL+ + ++K C Sbjct: 1596 AELEDERKQRSMAVAARKKLEMDLKDLEAHI--DSANKNRDEAIKQLRKLQAQMKDCMRE 1653 Query: 326 ------SLEKQLHSMKFSERRIE-------ELQDRINDLEKERELLKENYDKLYDSAFSA 372 S E+ L K +E++++ +LQ+ + E+ + ++ D+L D ++ Sbjct: 1654 LDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANS 1713 Query: 373 AHEEQWKLKEQQ-LKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQY 431 + + L+E++ L+ +IAQLE L+ + + I DRLK N ++ Q N +L L+ Sbjct: 1714 SGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLK---KANLQIDQINTDLNLE- 1769 Query: 432 LEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDL 491 Q+ + +++++ N+E + E+ + K + ++ L +++ + L Sbjct: 1770 RSHAQKNENARQQLERQNKELKVKLQEMEGTV------KSKYKASITALEAKIAQLEEQL 1823 Query: 492 ERSMRELQATHAETVQELEKTRNMLIM---QHKINKDYQMEVEAVTRKMENLQQDYELKV 548 + +E QA + + +K +++L+ + + + Y+ + + + +++ L++ E Sbjct: 1824 DNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAE 1883 Query: 549 EQYVHLLDIRAARIHKLEAQLKD 571 E+ A+R KL+ +L+D Sbjct: 1884 EEAQR---ANASR-RKLQRELED 1902 Score = 31.6 bits (70), Expect = 4.9 Identities = 26/109 (23%), Positives = 52/109 (47%), Gaps = 8/109 (7%) Query: 27 LQETSTTRTMKSRQAVSRVSREE--LEDRFLRLHDENILLKQHARKQEDKIKRMATKLIR 84 L+E T + + A +V R E L+D L++ DE +++A + +D+ + +T+L + Sbjct: 1819 LEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDE----RRNAEQYKDQADKASTRLKQ 1874 Query: 85 LVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRL 133 L + E R ++ E +E E + ++ +LKN+L Sbjct: 1875 LKRQLEEAEEEAQRANASRRKLQRE--LEDATETADAMNREVSSLKNKL 1921 >gi|156104874 envoplakin [Homo sapiens] Length = 2033 Score = 79.7 bits (195), Expect = 2e-14 Identities = 138/575 (24%), Positives = 240/575 (41%), Gaps = 88/575 (15%) Query: 35 TMKSRQAVSRVSREELEDRFLRLHDE-----NILLKQHARKQEDKIKRMATKLIRLVNDK 89 T++ ++ V R E LR D N L+ H R QE I+ + D+ Sbjct: 1247 TVEYKEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGER------DE 1300 Query: 90 KRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTP 149 R ER K + ++V E K LEK+ E L+ + A Q+ + Sbjct: 1301 WRRERAKVETKTVSKEVVRHE-------KDPVLEKEAERLRQEVREAAQKRRAA--EDAV 1351 Query: 150 YNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIR 209 Y R+ RRK E +QE + +D + E ++ SL EE G R Sbjct: 1352 YELQSKRLLLERRKPEEKVVVQEVV---VTQKDPKLREE----HSRLSGSLDEEV-GRRR 1403 Query: 210 NLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNV--- 266 LE +Q R +EE E L + + ++ E EL L LR Q+ + +++ + Sbjct: 1404 QLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQEKIIME 1463 Query: 267 EMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCS 326 E++KL K L++ LR D ELN + K +++ Sbjct: 1464 EVVKLEKD---------------PDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDV 1508 Query: 327 LEKQLHSMKFSERRIEELQ-DRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQL 385 L+K K + + +Q DR+ LE ER + E ++ +A A EE +L+E Sbjct: 1509 LQKAKSQEKTIYKEVIRVQKDRV--LEDERARVWEMLNR-ERTARQAREEEARRLRE--- 1562 Query: 386 KVQIAQLETALKSDLTDKTEILDRLKTERDQN-EKLVQENRELQLQYLEQKQQLDELKKR 444 +I + ET ++ +++E L R + + DQ +L QE R L+ Q ++QQ +L++ Sbjct: 1563 --RIDRAETLGRTWSREESE-LQRARDQADQECGRLQQELRALERQ---KQQQTLQLQEE 1616 Query: 445 IKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQA--TH 502 KL +Q+ + + AQ+ Q+ L + + + + ER++R+L A + Sbjct: 1617 SKLLSQKTESERQK--------AAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSR 1668 Query: 503 AETVQELEKTRNML-----IMQHKINKD---YQMEVEAVTRKMENLQ-QDYELKVEQYVH 553 E QE + L I++ + KD Y+ + + + LQ Q+ E E+ Sbjct: 1669 EELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTT 1728 Query: 554 ---------LLDIRAARIHKLEAQLKDIAYGTKQY 579 LLD ++ + + +EA L+ ++Y Sbjct: 1729 SGPCGEESVLLDRKSGKQYSIEAALRCRRISKEEY 1763 Score = 53.9 bits (128), Expect = 9e-07 Identities = 94/485 (19%), Positives = 202/485 (41%), Gaps = 78/485 (16%) Query: 112 IEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQ 171 + LQE + EK + +A+QQL Q + RR + G Sbjct: 846 VAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQG-S 904 Query: 172 ECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEI 231 E P + + +A A+ LEE R + +++ +++QR Q+ + Sbjct: 905 ESPAQAGRESEALKAQ-------------LEEERKRVARVQHELEAQRSQLLQ------- 944 Query: 232 LKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQ 291 L+TQ + E + + R+ Q S ++ VE + K+ L K +Q Sbjct: 945 LRTQRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVE--EEGKRRAGLQADLEVAAQKVVQ 1002 Query: 292 LQEKQRTL----------RISHD-ALMANGDELNMQLKEQRLKCCSLEKQLHSMKFS--- 337 L+ K++T+ ++ D L + +L +Q+++ R + + +L +K Sbjct: 1003 LESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLA 1062 Query: 338 -ERRIEELQDR-----INDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQ 391 E+R +++++ + +EK E++K AA +Q + +L+ +I Sbjct: 1063 LEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIED 1122 Query: 392 LETALKSD------------------LTDKTEILDRLKTERDQNEKLVQENRELQLQY-- 431 LE A+ S L + + + L+ ER +N L +E +L +Y Sbjct: 1123 LERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKYSV 1182 Query: 432 LEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDL 491 +E+++ +L++R+ Q + E + + +KA+ ++ G S + K++ Sbjct: 1183 VEKQRPKVQLQERVHEIFQVD----PETEQEITRLKAKLQEMAGK-------RSGVEKEV 1231 Query: 492 ERSMRELQATHAE--TVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVE 549 E+ + +L+ A+ TV+ E T+ +++H+ + + E++ + ++ L + E Sbjct: 1232 EKLLPDLEVLRAQKPTVEYKEVTQE--VVRHERSPEVLREIDRLKAQLNELVNSHGRSQE 1289 Query: 550 QYVHL 554 Q + L Sbjct: 1290 QLIRL 1294 Score = 53.5 bits (127), Expect = 1e-06 Identities = 119/633 (18%), Positives = 255/633 (40%), Gaps = 73/633 (11%) Query: 29 ETSTTRTMKSRQAVSRV-SREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVN 87 E R ++ +AV+++ +R E +R + + +++K+ + ++D + +R + Sbjct: 1100 EEDAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLL 1159 Query: 88 DKKRYERVGGGPKRLGRD----------VEMEEMIEQLQEKVHELEKQNETLKNRLISAK 137 +++R + L R+ VE + QLQE+VHE+ + + + + K Sbjct: 1160 EEERTKNA-----TLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRLK 1214 Query: 138 QQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYG 197 +LQ + +S + K + + + +++++ H + Sbjct: 1215 AKLQEMAGK-------RSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVL 1267 Query: 198 NSL--LEEARGEIRNLENVIQSQ--RGQIEELEHLAEILKTQLRRKENEI---------- 243 + L+ E+ N Q Q R Q E E E K + + E+ Sbjct: 1268 REIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHEKDPVLE 1327 Query: 244 -ELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRIS 302 E L+ ++A +R D V ++ + L+E+ + + + + +K LR Sbjct: 1328 KEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREE 1387 Query: 303 HDALMANGDE-----LNMQLKEQRLKCCSLEKQLHSMKFS---------ERRIEELQDRI 348 H L + DE ++L+ Q+L+ +E+Q + F ER + +L RI Sbjct: 1388 HSRLSGSLDEEVGRRRQLELEVQQLR-AGVEEQEGLLSFQEDRSKKLAVERELRQLTLRI 1446 Query: 349 NDLEK-----ERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDK 403 +LEK + +++ E KL E + Q K Q+ +L K +L + Sbjct: 1447 QELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQVTELNRECK-NLQVQ 1505 Query: 404 TEILDRLKTERDQNEK---LVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELS 460 ++L + K++ K VQ++R L+ +++ ++ E+ R + Q + A L Sbjct: 1506 IDVLQKAKSQEKTIYKEVIRVQKDRVLE----DERARVWEMLNRERTARQAREEEARRLR 1561 Query: 461 EALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQE-LEKTRNMLIMQ 519 E + + + + S L + + +++ R +EL+A + Q+ L+ ++ Sbjct: 1562 ERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQQTLQLQEESKLLS 1621 Query: 520 HKINKDYQMEV---EAVTRKMENLQQDYELKVEQYVHLLDIRAARIHK---LEAQLKDIA 573 K + Q + ++R + ++ + E+ L D+ A + E Q ++ Sbjct: 1622 QKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSREELSQETQTRETN 1681 Query: 574 YGTKQYKFKPEIMPDDSVDEFDETIHLERGENL 606 TK +PE D S E + ++RG+ L Sbjct: 1682 LSTKISILEPETGKDMSPYEAYKRGIIDRGQYL 1714 Score = 48.5 bits (114), Expect = 4e-05 Identities = 103/513 (20%), Positives = 203/513 (39%), Gaps = 80/513 (15%) Query: 103 GRDVEMEEMIEQLQEKVHELEKQNETLKNRLI---SAKQQLQTQGYRQTPYNNVQSRINT 159 G D + +E L++++ LEK+ +K +++ K + + + +Q + Sbjct: 1044 GEDAVISARLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDA 1103 Query: 160 GRRKANENA-------------GLQECPRKGIKFQDADVAETPHPM-FTKYGNSLLEEAR 205 RRK E A + K I + V + P + + SLLEE R Sbjct: 1104 ARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEER 1163 Query: 206 ----------GEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQA 255 ++ + +V++ QR +++ E + EI + E E E++ L+ + Q+ Sbjct: 1164 TKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVD---PETEQEITRLKAKLQEM 1220 Query: 256 TDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHD-ALMANGDELN 314 +RS + VE +L+ L A + + Q +R ++ D L Sbjct: 1221 AGKRSGVEKEVE------KLLPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLK 1274 Query: 315 MQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAH 374 QL E ++QL ++ + ++ +E+++ D + + Sbjct: 1275 AQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKEAERLR 1334 Query: 375 EEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERD---QNEKLVQENRELQLQY 431 +E + +++ + A E L K +L+R K E Q + Q++ +L+ ++ Sbjct: 1335 QEVREAAQKRRAAEDAVYE------LQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEH 1388 Query: 432 LEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDL 491 LDE R + +L + ++A E++ G LSF + D + Sbjct: 1389 SRLSGSLDEEVGRRR-----------QLELEVQQLRAGVEEQEGLLSF--QEDRSKKLAV 1435 Query: 492 ERSMRELQATHAETVQELEK----TRNMLIMQH--KINKDYQMEVEAVTRKMENLQQDYE 545 ER +R+L +QELEK + +IM+ K+ KD +E + E L+ D + Sbjct: 1436 ERELRQLTL----RIQELEKRPPTVQEKIIMEEVVKLEKDPDLE-----KSTEALRWDLD 1486 Query: 546 LKVEQYVHL------LDIRAARIHKLEAQLKDI 572 + Q L L ++ + K ++Q K I Sbjct: 1487 QEKTQVTELNRECKNLQVQIDVLQKAKSQEKTI 1519 >gi|21735548 centrosomal protein 2 [Homo sapiens] Length = 2442 Score = 79.0 bits (193), Expect = 3e-14 Identities = 120/552 (21%), Positives = 235/552 (42%), Gaps = 67/552 (12%) Query: 25 GGLQETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIR 84 G +QE R M+ EL L+ ++ + L+Q ++ +K + + L Sbjct: 1442 GQIQELEKQREMQKAAL-------ELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPM 1494 Query: 85 LVNDKKRYERVGGGPKR-LGRDVEMEEMIEQLQEKVHELEKQN---ETLKNRLISAKQQL 140 V ++++ V R L +D E + + L+ ++ ELEK++ E+ + ++ K+QL Sbjct: 1495 AVQEREQKLTVQREQIRELEKDRETQRNV--LEHQLLELEKKDQMIESQRGQVQDLKKQL 1552 Query: 141 QTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSL 200 T ++ ++ E G +E R + D+ E + + Sbjct: 1553 VTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIH 1612 Query: 201 LEEARG-----EIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIEL--SLLQLREQ 253 E+ E++ + ++SQR QIEEL+ E L L R++ E+ L +Q+ E Sbjct: 1613 DLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLED 1672 Query: 254 QATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDEL 313 Q T Q + +++E IKL L+E+ R L + +E Sbjct: 1673 QRTRQTKILEEDLEQIKL-------------------SLRERGRELTTQRQLMQERAEEG 1713 Query: 314 NMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLY-----DS 368 K QR SLE ++ E+ +E Q+ I++L++ ++ L++ L+ S Sbjct: 1714 KGPSKAQR---GSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETS 1770 Query: 369 AFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQN-EKLVQENREL 427 + E++ + +QQL+ Q E +S L + + R +RDQ E L QE ++ Sbjct: 1771 LLLSQREQEIVVLQQQLQEAREQGELKEQS-LQSQLDEAQRALAQRDQELEALQQEQQQA 1829 Query: 428 QLQYLEQKQQLDELKKRIKLYN----------QENDINADELSEALLLIKAQKEQKNGDL 477 Q Q K++ D L+ ++ + Q++ A L E L ++ ++ Q ++ Sbjct: 1830 QGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEE-LAVEGRRVQALEEV 1888 Query: 478 SFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNML----IMQHKINKDYQMEVEAV 533 ++ +S ++ E+++ LQ AE QE E L + + K+ E+EA+ Sbjct: 1889 LGDLRAES---REQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEAL 1945 Query: 534 TRKMENLQQDYE 545 + ++ + E Sbjct: 1946 RAESQSSRHQEE 1957 Score = 77.0 bits (188), Expect = 1e-13 Identities = 121/648 (18%), Positives = 271/648 (41%), Gaps = 91/648 (14%) Query: 42 VSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKR-YERVGGGPK 100 ++ +S E + +LH + +Q D+++++ +L +K + + + + Sbjct: 1233 LTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQR 1292 Query: 101 RLGRDVEMEEMIE----QLQEKVHELEKQNETLKNRLISAK-QQLQTQGYRQ-------- 147 +L ++ E + E L+ ++ EL + +L++RL A+ Q+++ QG R+ Sbjct: 1293 QLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKEN 1352 Query: 148 --TPYNNVQSRINTGRRKANENAGLQE---CPRKGIKFQDADVAETPHPMFTKYGNSLLE 202 ++Q+ + R +A+ L+E R +K ++ +V L+ Sbjct: 1353 LTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELK 1412 Query: 203 EARGE------------IRNLENVIQSQRGQIEELEH-------LAEILKTQLRRKENEI 243 A+G+ + E +++ RGQI+ELE E+L L+++ E+ Sbjct: 1413 VAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEV 1472 Query: 244 ELS-------------------LLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSA 284 +L +Q REQ+ T QR IR+ L K + N L Sbjct: 1473 DLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRE------LEKDRETQRNVL-- 1524 Query: 285 MEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEEL 344 E + ++L++K + + ++ +L QL LE+ H M+ ++ I+EL Sbjct: 1525 -EHQLLELEKKDQMI----ESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKEL 1579 Query: 345 QDRIN-----------DLEKERELLKENYDKLYD-SAFSAAHEEQWKLKEQQLKVQIAQL 392 + + DLE+ + L+ +++D + S + + ++Q++K Q Q+ Sbjct: 1580 EGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQI 1639 Query: 393 E--TALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQ 450 E K LT E D+ + + +++++ R Q + LE + L+++K ++ + Sbjct: 1640 EELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILE--EDLEQIKLSLRERGR 1697 Query: 451 ENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLE---RSMRELQATHAETVQ 507 E + E K + + G L + + + K++E + ELQ + Q Sbjct: 1698 ELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQ 1757 Query: 508 ELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEA 567 +L+ + + + E+ + ++++ ++ ELK + LD + + + Sbjct: 1758 QLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQ 1817 Query: 568 QLKDIAYGTKQYKFKPEIMPD--DSVDEFDETIHLERGENLFEIHINK 613 +L+ + +Q + + E + + D++ E H+ E E+ +K Sbjct: 1818 ELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHK 1865 Score = 71.2 bits (173), Expect = 6e-12 Identities = 122/594 (20%), Positives = 252/594 (42%), Gaps = 72/594 (12%) Query: 48 EELEDRFLRLHD---ENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGR 104 +EL+ + ++HD + +L + ++++ ++K ++ L K E + +R R Sbjct: 1602 QELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQK---EHLTQDLER--R 1656 Query: 105 DVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNV-QSRINTGRRK 163 D E+ E++Q + +Q + L+ L K L+ +G T + Q R G+ Sbjct: 1657 DQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGP 1716 Query: 164 ANENAGLQECPR-------KGIKFQDADVAETPH----------PMFTKYGNS--LLEEA 204 + G E + K ++ Q + E + K G + LL + Sbjct: 1717 SKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQR 1776 Query: 205 RGEIRNLENVIQSQR--GQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNI 262 EI L+ +Q R G+++E +++ + Q + + EL LQ +QQA Q + Sbjct: 1777 EQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERV 1836 Query: 263 RDNVEMIK-----LHKQLVEKSNALS-------------AMEGKFIQLQEK-----QRTL 299 ++ + ++ H L E+ L A+EG+ +Q E+ + Sbjct: 1837 KEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAES 1896 Query: 300 RISHDALMANGDELNMQLKEQRLKCCSLEKQLHS----MKFSERRIEELQDRINDLEKER 355 R AL+A + Q +E ++ +L+ +K ++ +E L+ + Sbjct: 1897 REQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQE 1956 Query: 356 ELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERD 415 E + + L + A AH + KEQ L Q A+L +L++ LD + Sbjct: 1957 EAARARAEALQE-ALGKAHAAL-QGKEQHLLEQ-AELSRSLEASTATLQASLDACQAHSR 2013 Query: 416 QNEKLVQ-ENRELQLQYLEQKQQLDELKKRIKLYNQE--NDINADELSEALLLIKAQKEQ 472 Q E+ ++ + E+Q Q L ++ + +L++ + ++E + ++L E L + Q+ Sbjct: 2014 QLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENM 2073 Query: 473 KNGDLSFLVKVDSEINKDLERSMRELQATHAETVQEL------EKTRNMLIMQHKINKDY 526 + + + E + L +S+RELQ T A+ QE+ ++ N+ + H +K Sbjct: 2074 IQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHS-HKTS 2132 Query: 527 QMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYK 580 ME +++ K+++L+ + ++E+ L AR + + +D+A Q K Sbjct: 2133 PMEEQSL--KLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTK 2184 Score = 66.6 bits (161), Expect = 1e-10 Identities = 117/574 (20%), Positives = 254/574 (44%), Gaps = 71/574 (12%) Query: 65 KQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMI-------EQLQE 117 ++ R+Q + +++ A +L R VN + + + G G+ E +E + E+LQE Sbjct: 472 REELRQQLEVLEQEAWRL-RRVNVELQLQ----GDSAQGQKEEQQEELHLAVRERERLQE 526 Query: 118 KVHELE-KQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRK 176 + LE KQ+E+L + LI+ ++ L++ Q+ + +A ++ Sbjct: 527 MLMGLEAKQSESL-SELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSEN 585 Query: 177 GIKFQDADVAETPHPMFTKYGNSLLEEA--RGEIRNLENVIQSQRGQIEELEHLAEILKT 234 +K + AD+ + L++ ++ LE QS ++E E L+ Sbjct: 586 TLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQV 645 Query: 235 QLRRKENEIEL-----SLLQLREQQATDQRSNIRDNVEMIKLHKQLVEK--SNALSAMEG 287 L E E + L+ + Q+A + + ++ ++ I+ K+ ++K S + E Sbjct: 646 DLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEA 705 Query: 288 KFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDR 347 QL++ + + + L E ++E+ +LE +L ++ ER ++L ++ Sbjct: 706 ATTQLEQLHQEAKRQEEVLARAVQEKEALVREK----AALEVRLQAV---ERDRQDLAEQ 758 Query: 348 INDLEKERELLKENYDKLYDSAFSAAHEEQW-KLKEQQLKVQIAQLETALKSDLTDKTEI 406 + L +ELL+ S F A + ++ + QL+VQI Q T K + + Sbjct: 759 LQGLSSAKELLES-------SLFEAQQQNSVIEVTKGQLEVQI-QTVTQAKEVIQGEVRC 810 Query: 407 LD-RLKTERDQNEK--------LVQENRE----LQLQYLEQKQQLDELKKRIKLYNQEND 453 L L TER Q E+ L Q +E L+ Q ++++++L+++ + +E Sbjct: 811 LKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREK---WEKERS 867 Query: 454 INADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQ-----E 508 + EL++AL ++ +K + L + + + ++ RE + T AE+ E Sbjct: 868 WHQQELAKALESLEREKMELEMRLK-----EQQTEMEAIQAQREEERTQAESALCQMQLE 922 Query: 509 LEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQ 568 EK R L+ + Q E+ ++++E L+QD +++ + I ++ + + + Sbjct: 923 TEKERVSLL---ETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRE 979 Query: 569 LKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLER 602 LK+ A +Q++ + ++S + + L++ Sbjct: 980 LKEAA---RQHRDDLAALQEESSSLLQDKMDLQK 1010 Score = 65.5 bits (158), Expect = 3e-10 Identities = 101/500 (20%), Positives = 219/500 (43%), Gaps = 67/500 (13%) Query: 115 LQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINT-GRRKANENAGLQEC 173 L +++ +LE++N+++ +R+ +A+Q + Q + R + + A LQ+ Sbjct: 615 LNQQLLQLEEENQSVCSRMEAAEQ---ARNALQVDLAEAEKRREALWEKNTHLEAQLQKA 671 Query: 174 PRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQI-EELEHLAEIL 232 G + Q AD+ + +++ E R+ + +Q Q+ +E + E+L Sbjct: 672 EEAGAELQ-ADLRDIQEE------KEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVL 724 Query: 233 KTQLRRKENEI-ELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFI- 290 ++ KE + E + L++R Q R ++ + ++ + K+L+E S + + I Sbjct: 725 ARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIE 784 Query: 291 ----QLQEKQRTLRISHDALMANGDELNMQLKEQRLKC-------------------CSL 327 QL+ + +T+ + + + L ++L +R + +L Sbjct: 785 VTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTAL 844 Query: 328 EKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKV 387 E+Q + E+ + +L+++ EKER ++ K +S E + +LKEQQ ++ Sbjct: 845 EQQKAA---HEKEVNQLREK---WEKERSWHQQELAKALESLEREKMELEMRLKEQQTEM 898 Query: 388 QIAQLETALKSDLTDKTEILDRLKTERDQ---NEKLVQENREL-----QLQYLEQKQQLD 439 + Q + + + +L+TE+++ E L+Q +EL QL+ L Q ++ Sbjct: 899 EAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQ 958 Query: 440 ELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEI---NKDLERSMR 496 +LK++ + I +L EA +K Q DL+ L + S + DL++ + Sbjct: 959 KLKEQ-----ETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVE 1013 Query: 497 ELQA-------THAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRK-MENLQQDYELKV 548 +L++ + QE+++ ++I K+ + E ++T ME Q+ L+ Sbjct: 1014 DLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQE 1073 Query: 549 EQYVHLLDIRAARIHKLEAQ 568 + ++ A R EAQ Sbjct: 1074 ADSIRQQELSALRQDMQEAQ 1093 Score = 64.3 bits (155), Expect = 7e-10 Identities = 123/584 (21%), Positives = 227/584 (38%), Gaps = 103/584 (17%) Query: 115 LQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECP 174 L K ELEK+ LI K Q + S + T +K NE+ E Sbjct: 249 LLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNED---YEKM 305 Query: 175 RKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQS-QRGQIEELEHLAEILK 233 K ++ + ++ ET H ++ SL A+ E +L+ VI+ + +EE +++A Sbjct: 306 IKALR-ETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIA---- 360 Query: 234 TQLRRKENEIEL--SLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQ 291 Q EN +EL S+ + Q D+ + +V L + A+ + + Sbjct: 361 -QGSGHENSLELDSSIFSQFDYQDADKALTLVRSV--------LTRRRQAVQDLRQQLAG 411 Query: 292 LQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDL 351 QE L+ HD G L +L++ + +L Q +LQ ++ L Sbjct: 412 CQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQT----------VDLQGEVDSL 461 Query: 352 EKERELLKENYDKLY------------------------DSAFSAAHEEQWKL-----KE 382 KERELL++ ++L DSA E+Q +L + Sbjct: 462 SKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRER 521 Query: 383 QQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDEL- 441 ++L+ + LE L++ + + L++ + E L QE E+ +Q + EL Sbjct: 522 ERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELS 581 Query: 442 KKRIKLYNQENDINA-----DELSEALLLIKA-------QKEQKNGDLSFLVKVDSEINK 489 L + D+ A L+EAL L K Q E++N + ++ + Sbjct: 582 SSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARN 641 Query: 490 DLERSMRELQA---------THAET-VQELEKT--------RNMLIMQHKINK---DYQM 528 L+ + E + TH E +Q+ E+ R++ + +I K + + Sbjct: 642 ALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRH 701 Query: 529 EVEAVTRKMENLQQDYELKVEQYVHLLDIRAA----------RIHKLEAQLKDIAYGTKQ 578 + EA T ++E L Q+ + + E + + A R+ +E +D+A + Sbjct: 702 QQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQG 761 Query: 579 YKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSEVLQ 622 E++ + + +E + E+ I VT + EV+Q Sbjct: 762 LSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQ 805 Score = 60.5 bits (145), Expect = 1e-08 Identities = 98/439 (22%), Positives = 184/439 (41%), Gaps = 74/439 (16%) Query: 28 QETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVN 87 QE + Q + L++R L D K+ AR+ E+++ ++ L Sbjct: 1832 QEERVKEKADALQGALEQAHMTLKERHGELQDH----KEQARRLEEELAVEGRRVQAL-- 1885 Query: 88 DKKRYERVGGGPKRLGRDVE------MEEMIEQLQEKVHELEK---QNETLKNRLISAKQ 138 E V G + R+ E ++ EQ QE HE+E Q+ L+ + + ++ Sbjct: 1886 -----EEVLGDLRAESREQEKALLALQQQCAEQAQE--HEVETRALQDSWLQAQAVLKER 1938 Query: 139 QLQTQGYR-QTPYNNVQSRINTGRRKANENA-GLQECPRKGIKFQDADVAETPHPM--FT 194 + + R ++ + Q R +A + A G +G + + AE + T Sbjct: 1939 DQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEAST 1998 Query: 195 KYGNSLLEEARGEIRNLENVIQSQRGQI--------EELEHLAEILKTQ------LRRKE 240 + L+ + R LE ++ Q G+I E+++ L + L + + +E Sbjct: 1999 ATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQERE 2058 Query: 241 NEIELSLLQLREQQATDQRSNI---RDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQR 297 +E SL Q ++ ++ N+ R+ E+ LH+ + E L+ E + ++L+E Q+ Sbjct: 2059 QLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQ 2118 Query: 298 TLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKEREL 357 R + +AL + M+ EQ LK SLE +L +R +E LQ + E Sbjct: 2119 --RNNLEALPHSHKTSPME--EQSLKLDSLEPRL------QRELERLQAALRQTE----- 2163 Query: 358 LKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQN 417 A E +W+ K Q L + +AQ + ++ S L + L ERD Sbjct: 2164 ---------------AREIEWREKAQDLALSLAQTKASV-SSLQEVAMFLQASVLERDSE 2207 Query: 418 EKLVQENRELQLQYLEQKQ 436 ++ +Q+ EL + LE+++ Sbjct: 2208 QQRLQDELELTRRALEKER 2226 Score = 45.1 bits (105), Expect = 4e-04 Identities = 60/299 (20%), Positives = 138/299 (46%), Gaps = 31/299 (10%) Query: 106 VEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKAN 165 +E+E +++ Q ++ ++ Q E + + SA Q+Q + ++ + +++ + T + A+ Sbjct: 885 MELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKER-VSLLETLLQTQKELAD 943 Query: 166 ENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEEL 225 + L+ R+ +K Q ET + T+ L+EA+ R L+ + R + L Sbjct: 944 ASQQLERL-RQDMKVQKLKEQETTGILQTQ-----LQEAQ---RELKEAARQHRDDLAAL 994 Query: 226 EHLAEIL---KTQLRRKENEIELSLLQLREQQAT---DQRSNIRDNVEMIKLHKQLVEKS 279 + + L K L+++ +++ L+ + Q + + +R+ E ++ K+L + Sbjct: 995 QEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREK 1054 Query: 280 NALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSER 339 +L+ + L EK++ L + +A EL+ L++ + +K+L + Sbjct: 1055 ASLT------LSLMEKEQRLLVLQEADSIRQQELSA-LRQDMQEAQGEQKELSA------ 1101 Query: 340 RIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKS 398 ++E L+ + EKE + L + L + S E+Q + + + AQL+ L+S Sbjct: 1102 QMELLRQEVK--EKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRS 1158 Score = 35.4 bits (80), Expect = 0.34 Identities = 33/159 (20%), Positives = 70/159 (44%), Gaps = 12/159 (7%) Query: 380 LKEQQLKVQIAQLETALKSDLTDKTEILDR-LKTERDQNEKLVQENRELQLQYLEQKQQL 438 +K Q L++ + + AL+ + + R LK ++ ++ R+LQ + L+ + Sbjct: 11 MKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWC 70 Query: 439 DELKKRIKLYN---QENDINADELSEALLLIKAQKEQK--------NGDLSFLVKVDSEI 487 EL+KR++ + N +E + LL++ ++EQ+ N L ++ + Sbjct: 71 QELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVV 130 Query: 488 NKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDY 526 NK L + +L + EL + + M+ + K Y Sbjct: 131 NKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGY 169 Score = 35.0 bits (79), Expect = 0.44 Identities = 68/344 (19%), Positives = 143/344 (41%), Gaps = 50/344 (14%) Query: 243 IELSLLQLREQQATDQRSN---IRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEK---- 295 +E +L L++Q A +Q ++ ++++ E + LV K A + Q EK Sbjct: 20 LEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEA 79 Query: 296 ------QRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRIN 349 QR + L DEL ++L+E++ +C SL + ++ + + + Sbjct: 80 TGGPIPQRWENVEEPNL----DELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKA-- 133 Query: 350 DLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDR 409 L ++ E L ++ + D E QW+++++ K Sbjct: 134 -LREDVEKLTVDWSRARDELMRK--ESQWQMEQEFFK---------------------GY 169 Query: 410 LKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEAL-LLIKA 468 LK E + L +E + +LE K D + ++L + ++ L+ L L + A Sbjct: 170 LKGEHGRLLSLWREVVTFRRHFLEMKSATD--RDLMELKAEHVRLSGSLLTCCLRLTVGA 227 Query: 469 QKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQM 528 Q + NG + +++ L ++ +EL+ E QEL + ++ ++ +D Sbjct: 228 QSREPNGSGRMDGREPAQLLLLLAKT-QELEKEAHERSQELIQLKSQGDLEKAELQDRVT 286 Query: 529 EVEAVTRKMENLQQDYELKVE---QYVHLLDIRAARIHKLEAQL 569 E+ A+ + + +DYE ++ + V +L+ + + EA L Sbjct: 287 ELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASL 330 >gi|4885583 Rho-associated, coiled-coil containing protein kinase 1 [Homo sapiens] Length = 1354 Score = 78.6 bits (192), Expect = 3e-14 Identities = 130/562 (23%), Positives = 239/562 (42%), Gaps = 80/562 (14%) Query: 28 QETSTTRTMKSRQAVSRVS--REELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRL 85 Q + K R + VS +++LED L+ +N L Q K A L+R Sbjct: 499 QRKAEQENEKRRNVENEVSTLKDQLED--LKKVSQNSQLANEKLSQLQKQLEEANDLLRT 556 Query: 86 VNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGY 145 +D R EM + I QL+ EL+++N L+N ++ Sbjct: 557 ESDTAVRLRKS--------HTEMSKSISQLESLNRELQERNRILEN----------SKSQ 598 Query: 146 RQTPYNNVQSRINTGRR-KANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEA 204 Y +Q+ + RR + +++ + + + Q+ E H K+ +E Sbjct: 599 TDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQE----EVKH---LKHNLEKVEGE 651 Query: 205 RGEIRNLENVIQSQRGQIE-ELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIR 263 R E +++ N + ++ +E +L + + L+ +L ++ NE +++ +L TD+ +I Sbjct: 652 RKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARL-----TDKHQSIE 706 Query: 264 D--NVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQR 321 + +V M ++ K+L E+ A E + +Q+ EKQ ++ L++ LK+ Sbjct: 707 EAKSVAMCEMEKKLKEEREAREKAENRVVQI-EKQCSM-------------LDVDLKQ-- 750 Query: 322 LKCCSLEKQLHSMKFSERRIEELQDRINDLEKE--RELLKENYDKLYDSAFSAAHEEQWK 379 S +K H ER +E+++ LE+E + LL +N +L AF A + K Sbjct: 751 ----SQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQN--ELKTQAFEA---DNLK 801 Query: 380 LKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLD 439 E+Q+K +I L A + + ++ + + Q +L + Q K Q+ Sbjct: 802 GLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVK 861 Query: 440 ELKKRIKLYNQENDINADELSEA---------LLLIKAQKEQKNGDL--SFLVKVDSEIN 488 ELK+ I+ N+EN EL L KA+ EQ L ++ E Sbjct: 862 ELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQESK 921 Query: 489 KDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKV 548 K R+ +E+ TV LE+ +ML +I + E E +T KM+ +++Y+L+ Sbjct: 922 KAASRNRQEI-TDKDHTVSRLEEANSMLTKDIEI---LRRENEELTEKMKKAEEEYKLEK 977 Query: 549 EQYVHLLDIRAARIHKLEAQLK 570 E+ + L + E LK Sbjct: 978 EEEISNLKAAFEKNINTERTLK 999 Score = 73.6 bits (179), Expect = 1e-12 Identities = 99/501 (19%), Positives = 227/501 (45%), Gaps = 38/501 (7%) Query: 228 LAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEG 287 L E L+ + + E ++ + +QL+++ R++ N+++ K+ K+L E+ N +E Sbjct: 424 LQESLQKTIYKLEEQLH-NEMQLKDEMEQKCRTS---NIKLDKIMKELDEEGNQRRNLES 479 Query: 288 KFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDR 347 Q+++++ L+ + ++ N + + + +L+ QL +K + + ++ Sbjct: 480 TVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEK 539 Query: 348 INDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEIL 407 ++ L+K+ L+E D L + +A + + ++ I+QLE +L +L ++ IL Sbjct: 540 LSQLQKQ---LEEANDLLRTESDTAV---RLRKSHTEMSKSISQLE-SLNRELQERNRIL 592 Query: 408 DRLKTERDQNEKLVQENRELQLQYL-EQKQQLDELKKRIKLYNQE--------NDINADE 458 + K++ D++ +Q E + + + + +L+ RI +E + + Sbjct: 593 ENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGER 652 Query: 459 LSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETV---QELEKTRN- 514 +L ++KE+ N ++ K+ S + + LE+ + E + T A Q +E+ ++ Sbjct: 653 KEAQDMLNHSEKEKNNLEIDLNYKLKS-LQQRLEQEVNEHKVTKARLTDKHQSIEEAKSV 711 Query: 515 -MLIMQHKINKDYQMEVEAVTRKMENLQQ----DYELKVEQYVHLLDIRAARIHKLEAQL 569 M M+ K+ ++ + +A R ++ +Q D +LK Q L+ ++E ++ Sbjct: 712 AMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQ--QKLEHLTGNKERMEDEV 769 Query: 570 KDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSEVLQASGDKEP 629 K++ +Q K ++ ++ + E +L+ E + IN + + +L+ Sbjct: 770 KNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFE----- 824 Query: 630 VTFCTYAFYDFELQTTPVVRGLHPEYNFTSQYLVHVNDLFLQYIQKNTITLEVHQAYSTE 689 + T + E Q + L E F++ Y V +L + +KN L+ Q E Sbjct: 825 LAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNE 884 Query: 690 YETIAACQLKFHEILEKSGRI 710 ET+A QL E +S ++ Sbjct: 885 KETLAT-QLDLAETKAESEQL 904 Score = 67.0 bits (162), Expect = 1e-10 Identities = 98/494 (19%), Positives = 214/494 (43%), Gaps = 78/494 (15%) Query: 29 ETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHAR--KQEDKIKRMATKLIRLV 86 E S ++T K + + E DR HD ++ AR ++++K + L ++ Sbjct: 593 ENSKSQTDKDYYQLQAILEAERRDRG---HDSEMIGDLQARITSLQEEVKHLKHNLEKVE 649 Query: 87 NDKKRYERV--GGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQG 144 ++K + + ++ ++++ ++ LQ+++ + +++ K RL Q ++ Sbjct: 650 GERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEA- 708 Query: 145 YRQTPYNNVQSRINTGR--RKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLE 202 + ++ ++ R R+ EN +Q K D D+ ++ + GN E Sbjct: 709 -KSVAMCEMEKKLKEEREAREKAENRVVQI--EKQCSMLDVDLKQSQQKLEHLTGNK--E 763 Query: 203 EARGEIRNL--------------ENVIQSQRGQIEELEHLAEILKTQLR---RKENEIEL 245 E++NL +N +++Q + + L+ L + +K ++ + +E Sbjct: 764 RMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEF 823 Query: 246 SLLQLREQQATD--QRSNIRDNVE-----------MIKLHKQLVEKSNALSAMEGKFIQL 292 L QL +Q + Q ++D +E +K K+ +E+ N + K +L Sbjct: 824 ELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLK--KIQEL 881 Query: 293 QEKQRTLRISHDAL--------MANG--DELNMQLKEQRLKCCSLEKQLHSMKFSERRIE 342 Q ++ TL D +A G +E +L ++ K S +Q + K + + Sbjct: 882 QNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDK--DHTVS 939 Query: 343 ELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKL-KEQQLKVQIAQLETALKSDLT 401 L++ + L K+ E+L+ ++L + A EE++KL KE+++ A E + ++ T Sbjct: 940 RLEEANSMLTKDIEILRRENEELTEKMKKA--EEEYKLEKEEEISNLKAAFEKNINTERT 997 Query: 402 DKTEI--------------LDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKL 447 KT+ +DR K K +ENR+LQL+ +++++ +++ +K Sbjct: 998 LKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMV--VKH 1055 Query: 448 YNQENDINADELSE 461 + ND+ A + E Sbjct: 1056 QKELNDMQAQLVEE 1069 >gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens] Length = 3907 Score = 78.6 bits (192), Expect = 3e-14 Identities = 108/524 (20%), Positives = 219/524 (41%), Gaps = 48/524 (9%) Query: 114 QLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQEC 173 Q+QEK +++ L+ L+ A +LQ Q + ++ + AG Sbjct: 1937 QIQEKTDIIDR----LEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAG---- 1988 Query: 174 PRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILK 233 P + Q+ + + ++ + +++ LE ++ Q + ELE Sbjct: 1989 PVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTEL 2048 Query: 234 TQLRRKENEIELSLLQLR---EQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFI 290 LR++ +E L ++R ++QA D R + RD + +Q ++K + +F Sbjct: 2049 MDLRQQNQALEKQLEKMRKFLDEQAID-REHERD------VFQQEIQKLEQQLKVVPRFQ 2101 Query: 291 QLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSL----EKQLHSMKFSERRIEELQD 346 + E Q ++L LKE+ KC L E+ ++ IE+L+ Sbjct: 2102 PISEHQTR----------EVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF 2151 Query: 347 RINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEI 406 R+ +LE+ + + + K+ D A E + E L+VQ+ A+ + T + Sbjct: 2152 RVRELEQALLVSADTFQKVEDRKHFGAVEAK---PELSLEVQLQAERDAIDRKEKEITNL 2208 Query: 407 LDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLI 466 ++L+ R E+L +N E+Q +++ + Q E R++ QEN + D++ + L I Sbjct: 2209 EEQLEQFR---EELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAI 2265 Query: 467 KAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHK--INK 524 K D L ++I ++ E + +L + Q+L+ T + +++ K + + Sbjct: 2266 KESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIR 2325 Query: 525 DYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPE 584 D + ++E + E ++++ E ++EQ + I KL+ +L +I T Sbjct: 2326 DLETQIECLMSDQECVKRNREEEIEQLNEV-------IEKLQQELANIGQKTSMNAHSLS 2378 Query: 585 IMPDDSVDEFDETIHLERG-ENLFEIHINKVTFSSEVLQASGDK 627 D + D I + E E ++TF VL+ + K Sbjct: 2379 EEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFK 2422 Score = 73.6 bits (179), Expect = 1e-12 Identities = 119/564 (21%), Positives = 249/564 (44%), Gaps = 95/564 (16%) Query: 29 ETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMA-----TKLI 83 ET T S A +++++ +L +++ LL+ + +K+ED +++ K+ Sbjct: 249 ETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVY 308 Query: 84 RLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQ---QL 140 + DKK V K E E +IE+L K+ E EK+ LK++L +A + +L Sbjct: 309 EMEQDKK----VENSNKE--EIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGEL 362 Query: 141 QTQ-GYRQTPYNNVQSRINTGRRKANENA-----------GLQECPRKGIKFQDADVAET 188 Q Q + N++ + ++K +++ LQ+ K +F+ V Sbjct: 363 QEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRM 422 Query: 189 PHPMFTKYGNSLLEEARGEIRNL--ENVIQSQRGQIEELEHLAEILKTQLRRKENEIELS 246 K LE+ R E+ + + ++Q ++ I +H+A++ + + R K E+E Sbjct: 423 EQETQRK-----LEQLRAELDEMYGQQIVQMKQELIR--QHMAQMEEMKTRHK-GEME-- 472 Query: 247 LLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDAL 306 A SNI N + IKL + + N I+LQ+ ++ Sbjct: 473 -------NALRSYSNITVNEDQIKLMNVAINELN---------IKLQD-------TNSQK 509 Query: 307 MANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLY 366 +EL + L+E+ C+L++QL + +EEL +++ R+ + E KL Sbjct: 510 EKLKEELGLILEEK----CALQRQLEDL------VEELSFSREQIQRARQTIAEQESKLN 559 Query: 367 DSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRE 426 ++ S + E K + +LE ++++T+ L+ L+ E++ + E++E Sbjct: 560 EAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQE 619 Query: 427 LQLQYL------EQKQQLDELKKRIKL----------------YNQENDINADELSEALL 464 +L+ L +++L +LK+ +++ Y Q+ D +E+S+ + Sbjct: 620 AELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIE 679 Query: 465 LIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAE-TVQELEKTRNMLIMQHKIN 523 ++ +K+ + L+ S++ KDL++S+ ++ + EL+K +L + K Sbjct: 680 TMQFEKDNLITKQNQLILEISKL-KDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEK 738 Query: 524 KDYQMEVEAVTRKMENLQQDYELK 547 + EV+ + K E L++ + K Sbjct: 739 GTLEQEVQELQLKTELLEKQMKEK 762 Score = 71.6 bits (174), Expect = 4e-12 Identities = 96/540 (17%), Positives = 223/540 (41%), Gaps = 55/540 (10%) Query: 48 EELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVE 107 +ELE ++ +E LL + + + + +L++ + ++L + Sbjct: 1960 QELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMK--------EKLEVQCQ 2011 Query: 108 MEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANEN 167 E++ + LQ++V LE E +R I +Q+ T+ N + RK + Sbjct: 2012 AEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE 2071 Query: 168 AGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEH 227 + + + Q+ E + ++ + E E+ L N ++ + + EL Sbjct: 2072 QAIDREHERDVFQQEIQKLEQQLKVVPRF-QPISEHQTREVEQLANHLKEKTDKCSELLL 2130 Query: 228 LAEILKTQLRRKENEIELSLLQLREQQ-----ATDQRSNIRDNVEM--------IKLHKQ 274 E L+ ++ + EIE ++RE + + D + D + L Q Sbjct: 2131 SKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQ 2190 Query: 275 LVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSM 334 L + +A+ E + L+E+ R + +L+MQL+ Q+ + + +L + Sbjct: 2191 LQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTT---RLQEL 2247 Query: 335 KFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLET 394 + + ++ +++ KE + + + F+ +E+ +++ QL Q+ +L+ Sbjct: 2248 EQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEK-EVEIDQLNEQVTKLQQ 2306 Query: 395 ALKSD-----LTDKTEILDRLKTERD---QNEKLVQENRELQLQYLEQKQQLDELKKRIK 446 LK + +K E++ L+T+ + +++ V+ NRE +++ L + +++L++ + Sbjct: 2307 QLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEV--IEKLQQELA 2364 Query: 447 LYNQENDINADELSEAL--------------LLIKAQKEQKNGDLSFLVKVDSEINKDLE 492 Q+ +NA LSE L ++ Q E N +++F+ V E N + Sbjct: 2365 NIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMN 2424 Query: 493 RSMREL-----QATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELK 547 + +EL + E +Q + + + + H ++EV +++L+ K Sbjct: 2425 QLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFK 2484 Score = 70.5 bits (171), Expect = 1e-11 Identities = 97/513 (18%), Positives = 222/513 (43%), Gaps = 74/513 (14%) Query: 108 MEEMIEQLQEKVHELEKQNETLKNRLIS----AKQQLQ----TQGYRQTPYNNVQSRINT 159 +E M +L K HE+E+ N L+ ++ QQLQ R + + + Sbjct: 157 LEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQ 216 Query: 160 GRRKANENAG-----LQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENV 214 RR+ +E ++ + I+FQ +ET NS ++ + Sbjct: 217 ARREKDETMREFLELTEQSQKLQIQFQQLQASET-------LRNSTHSSTAADLLQAKQQ 269 Query: 215 IQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQ--LREQQATDQRSNIRDNVEMIKLH 272 I + + Q+EE +HL E Q ++++ +++S LQ ++ + + N E I+ Sbjct: 270 ILTHQQQLEEQDHLLE--DYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEK 327 Query: 273 KQLVEKSNA-LSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQL 331 + ++E+ N + E K ++L++K T D L+ EL Q+ ++ + +++ +L Sbjct: 328 ETIIEELNTKIIEEEKKTLELKDKLTTA----DKLLG---ELQEQIVQKNQEIKNMKLEL 380 Query: 332 HSMKFSERR-----------IEELQDRIN---------------DLEKERELLKENYDKL 365 + K ER+ +EELQ R + + +++ E L+ D++ Sbjct: 381 TNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEM 440 Query: 366 YDSAFSAAHEEQWKLKEQQLKVQIAQLE---TALKSDLTDKTEILDRLKTERDQNEKLVQ 422 Y ++ ++K++ ++ +AQ+E T K ++ + + DQ + + Sbjct: 441 YG-------QQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNV 493 Query: 423 ENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVK 482 EL ++ + Q ++LK+ + L +E +L + + + +EQ + + Sbjct: 494 AINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAE 553 Query: 483 VDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRK----ME 538 +S++N + +S+ ++ AE V E + + + +Y++++E + ++ ++ Sbjct: 554 QESKLN-EAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLD 612 Query: 539 NLQQDYELKVEQY-VHLLDIRAARIHKLEAQLK 570 + + E ++E+ LL + KL+ L+ Sbjct: 613 RMAESQEAELERLRTQLLFSHEEELSKLKEDLE 645 Score = 70.1 bits (170), Expect = 1e-11 Identities = 124/572 (21%), Positives = 252/572 (44%), Gaps = 116/572 (20%) Query: 31 STTRTMKSRQAVSRVSREELEDRF--------LRLH----DENILLKQHARKQEDKIKRM 78 ST +K+ + SR+ELE + ++L ++N +L + A QE +++R+ Sbjct: 566 STVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERL 625 Query: 79 ATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMI--EQLQEKVH-ELEKQNETLKNRLIS 135 T+L+ ++ +L D+E+E I E+L++ + ++Q + L+N + Sbjct: 626 RTQLLFSHEEEL---------SKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEM-- 674 Query: 136 AKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTK 195 Q+++T + + +N+ ++ N + ++ LQ+ + + T Sbjct: 675 -SQKIETMQFEK---DNLITKQNQLILEISKLKDLQQ-----------SLVNSKSEEMTL 719 Query: 196 YGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQA 255 N L +E +R E + +++EL+ E+L+ Q++ KEN+++ QL + + Sbjct: 720 QINELQKEIE-ILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENS 778 Query: 256 T--DQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDEL 313 D++ + D M+K+H + ++ + I+ + K + L+ ++L Sbjct: 779 ILKDEKKTLED---MLKIHTPVSQEERLIFLDS---IKSKSKDSVWEKEIEILIEENEDL 832 Query: 314 N---MQLKEQRLKCCSLEKQLHSMKFSERRIE----ELQDRINDLEKERELLKENYDKL- 365 +QL E+ +EKQ ++ F+E+ E ELQ+ L K ++ L+++ +K Sbjct: 833 KQQCIQLNEE------IEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQE 886 Query: 366 --YDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQE 423 Y S A +EE L Q++ ++++++ + DKT + + L + E + ++ Sbjct: 887 LEYKSKLKALNEE---LHLQRINPTTVKMKSSVFDE--DKTFVAETL----EMGEVVEKD 937 Query: 424 NRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFL--- 480 EL + E+ KR KL ELS+ L + Q +QK+G++SFL Sbjct: 938 TTELMEKL--------EVTKREKL----------ELSQRLSDLSEQLKQKHGEISFLNEE 979 Query: 481 VKVDSEINKDLERSMRELQA----THAETVQELEKTRNMLI-------------MQHKIN 523 VK + + + REL+ AE VQ + + L+ K+N Sbjct: 980 VKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVN 1039 Query: 524 KDYQMEVEAVTR---KMENLQQDYELKVEQYV 552 K + E + + EN+ E K EQ + Sbjct: 1040 KSFGEESKIMVEDKVSFENMTVGEESKQEQLI 1071 Score = 60.8 bits (146), Expect = 8e-09 Identities = 122/632 (19%), Positives = 266/632 (42%), Gaps = 101/632 (15%) Query: 57 LHDENILLKQHARKQ----EDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMI 112 +HDE + A +Q E++++ M +L+R + ++ + + + E+ Sbjct: 1565 IHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQ- 1623 Query: 113 EQLQEKVHELEKQ--------NETLKNRL-------ISAKQQLQTQGYRQTPYNNVQSRI 157 EQLQE++ L +Q NE L + + A +QL G + S Sbjct: 1624 EQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSST 1683 Query: 158 NTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQS 217 T + NEN G E K D + P + + +L + ++ L V+++ Sbjct: 1684 QT--QNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKT 1741 Query: 218 QRGQIEEL-EHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLV 276 E + H+ IL R +++ SL+ E +A+ +S + + H ++ Sbjct: 1742 TAAVEETIGRHVLGILD---RSSKSQSSASLIWRSEAEAS-VKSCVHEE------HTRVT 1791 Query: 277 EKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKF 336 ++S + + G + + +++ + G EL+ +L ++ + + Sbjct: 1792 DES--IPSYSGSDMPRNDINMWSKVTEE-----GTELSQRLVRSGFAGTEIDPENEELML 1844 Query: 337 S---------ERRIEELQDRINDLEKER----ELLKENYDKLYDSAFSAAHEEQWKLK-- 381 + E+ +E + + + LE + EL++E++ + ++ S +E+ + + Sbjct: 1845 NISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLH 1904 Query: 382 -----EQQLKVQIAQLE----------TALKSDLTDKTEILDRLKTERDQNEKLVQENRE 426 +QL V++++ E T + + +KT+I+DRL+ E +QE Sbjct: 1905 EESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEA 1964 Query: 427 LQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSE 486 Q Q E+++ L K+ +K + + L E L+K + E V+ +E Sbjct: 1965 EQQQIQEERELLSRQKEAMKA--EAGPVEQQLLQETEKLMKEKLE---------VQCQAE 2013 Query: 487 -INKDLERSMRELQATHAETVQ---ELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQ 542 + DL++ ++ L+ E V ELE+ +N +M D + + +A+ +++E +++ Sbjct: 2014 KVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELM------DLRQQNQALEKQLEKMRK 2067 Query: 543 DYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETI-HL- 600 + + H D+ I KLE QLK + +F+P + + E ++ HL Sbjct: 2068 FLDEQAIDREHERDVFQQEIQKLEQQLKVVP------RFQP--ISEHQTREVEQLANHLK 2119 Query: 601 ERGENLFEIHINKVTFSSEVLQASGDKEPVTF 632 E+ + E+ ++K ++ + + + E + F Sbjct: 2120 EKTDKCSELLLSKEQLQRDIQERNEEIEKLEF 2151 Score = 55.5 bits (132), Expect = 3e-07 Identities = 98/442 (22%), Positives = 193/442 (43%), Gaps = 90/442 (20%) Query: 196 YGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQA 255 Y +S E+ + R E ++ Q+ +EE L +T+L + LL EQ+ Sbjct: 3010 YDSSQSHESFSDWRG-ELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRI 3068 Query: 256 TDQRSNIRDNVEMIKL--HKQLVEKSNALSA-MEGKFIQLQEKQRTLRISHDALMANGDE 312 +Q + +E ++ + L+ + AL A M G+ I L+ +Q + + S + L E Sbjct: 3069 QEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELL-----E 3123 Query: 313 LNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRIND-----LEKERELLKENYDKLYD 367 N+Q K+ ++ ++ +L SMK R ELQ++++ E + EL + + + Sbjct: 3124 YNIQQKQSQM--LEMQVELSSMK---DRATELQEQLSSEKMVVAELKSELAQTKLE--LE 3176 Query: 368 SAFSAAHEEQWKLKEQQLKV-----QIAQLETALKSDLTDKTEI---LDRLKT------E 413 + A H+ +L+ +L+V ++ L L S+ E+ L++ K E Sbjct: 3177 TTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEE 3236 Query: 414 RDQN---------EKLVQENRELQLQYLEQKQQLDELKKRIK----LYNQENDINADELS 460 RD+ E Q N +L L +QKQ L+E +++I+ LY+ + Sbjct: 3237 RDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNL 3296 Query: 461 EALLLIKAQKEQKNGDLSFLVKVDSEINKDLERS-------------------MRELQAT 501 E +L++++K + ++S + + E++ L+ S ++L+ Sbjct: 3297 ELQVLLESEKVRIR-EMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEK 3355 Query: 502 HA-----------------ETVQELEKTRNM----LIMQHKINKDYQMEVEAVTRKMENL 540 H+ +T Q++EK R + L + + N + Q ++ + K+E+L Sbjct: 3356 HSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDL 3415 Query: 541 QQDYELKVEQYVHLLDIRAARI 562 Q+ E K Q V+ LD+ R+ Sbjct: 3416 QRQLEEK-RQQVYKLDLEGQRL 3436 Score = 43.5 bits (101), Expect = 0.001 Identities = 65/316 (20%), Positives = 132/316 (41%), Gaps = 21/316 (6%) Query: 311 DELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAF 370 +ELN +L+E R+ + + L ++ E I++ I L + + D+ Sbjct: 172 EELNRELEEMRVTYGT--EGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFL 229 Query: 371 SAAHEEQ-WKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQL 429 + Q +++ QQL+ + S D + ++ T + Q E+ + Q Sbjct: 230 ELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQK 289 Query: 430 QYLEQKQQLDELKKRIKLYNQEND-----INADELSEALLLIKAQKEQKNGDLSFLVKVD 484 + + Q+ L+++IK+Y E D N +E+ E +I E+ N + K Sbjct: 290 KKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETII----EELNTKIIEEEKKT 345 Query: 485 SEINKDLERSMRELQATHAETVQELEKTRNM-LIMQHKINKDYQM--EVEAVTRKMENLQ 541 E+ L + + L + VQ+ ++ +NM L + + K+ Q E++ + +E LQ Sbjct: 346 LELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQ 405 Query: 542 ----QDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVD-EFDE 596 +D + + + + ++ +L A+L D YG + + K E++ E + Sbjct: 406 KRNHKDSQFETDIVQRMEQETQRKLEQLRAEL-DEMYGQQIVQMKQELIRQHMAQMEEMK 464 Query: 597 TIHLERGENLFEIHIN 612 T H EN + N Sbjct: 465 TRHKGEMENALRSYSN 480 Score = 38.1 bits (87), Expect = 0.052 Identities = 98/532 (18%), Positives = 210/532 (39%), Gaps = 73/532 (13%) Query: 35 TMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYER 94 T+K Q + S+E LE + + + ++ +D+ AT+L ++ +K Sbjct: 3107 TLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDR----ATELQEQLSSEKMV-- 3160 Query: 95 VGGGPKRLGRD-VEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNV 153 V L + +E+E ++ + + ELE +K++ T Q + Sbjct: 3161 VAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSREL 3220 Query: 154 QSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLEN 213 Q + + K + + + +KF + + N LLE+ + + + Sbjct: 3221 QWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQL-----NLLLEQQKQLLNESQQ 3275 Query: 214 VIQSQR-----------GQIEELEHLAEILKTQLRRKENEIELSL---LQLREQQATDQR 259 I+SQR G+ EL+ L E K ++R + ++ QL+ T Q Sbjct: 3276 KIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQS 3335 Query: 260 SNIRDNVEMIK-LHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLK 318 + +++K L KQL EK + + ++L + ++ D+L K Sbjct: 3336 RPPLPSEDLLKELQKQLEEKHS-------RIVELLNETEKYKL--DSLQTR----QQMEK 3382 Query: 319 EQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKL----------YDS 368 ++++ +L+ + + ++++ ELQ ++ DL+++ E ++ KL Sbjct: 3383 DRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQE 3442 Query: 369 AFSAAHEEQWKLKEQQLKVQIAQLET--ALKSDLTDKTEILDRLKTERDQNE--KLVQEN 424 E + K + +++ Q T +L SD T + +++ E ++ KL++ N Sbjct: 3443 FQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMN 3502 Query: 425 R-----ELQLQYLEQKQQLDELKKRI-----------KLYNQENDINADELSEALLLIKA 468 +L+ + QK Q K ++ + + E+ I E + ++L Sbjct: 3503 GGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQ 3562 Query: 469 QKEQKNGDLSFLVKVDSEINKDLERSMR---ELQATHAETVQELEKTRNMLI 517 + + G+ LV + ER +R EL ++ +E RNM++ Sbjct: 3563 KLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVM 3614 Score = 37.4 bits (85), Expect = 0.089 Identities = 75/358 (20%), Positives = 153/358 (42%), Gaps = 44/358 (12%) Query: 207 EIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNV 266 ++ NLE++ + + ++ L+ L KT+L + E+E SL+ +QQ + N + Sbjct: 1310 QMTNLEDIDVNHKSKLSSLQDLE---KTKLEEQVQELE-SLISSLQQQLKETEQNYEAEI 1365 Query: 267 EMIKLHKQLVEKSNALSAM--EGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKC 324 ++ Q V +S ++ + I + QRT+ Sbjct: 1366 HCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPG---------------------S 1404 Query: 325 CSLEKQLHSMKFS-ERRIEELQDRINDLEKE-RELLKENYDKLYDSAFSAAHEEQWKLKE 382 C + +++FS E ++E + + LEK+ +E L+E K+ S S A +Q +L Sbjct: 1405 CVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVS-MSIAFAQQTELSR 1463 Query: 383 QQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQL--QYLEQKQQLDE 440 + + + + +K +DQ E +++ ++ ++L E Sbjct: 1464 ISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGE 1523 Query: 441 LKKRIKLYNQE-NDINADELSEALLLIKAQKEQKNGDLSFLVK--VDSEINKDLERSMRE 497 K I L N + +DI E + +L I +E + D +F+V+ + EI+ + R+ Sbjct: 1524 HGKEILLSNSDPHDI--PESKDCVLTI--SEEMFSKDKTFIVRQSIHDEISVSSMDASRQ 1579 Query: 498 LQATHAETVQELEKTRNMLIMQHKINKD-YQMEVEAVTRKMENLQQDYELKVEQYVHL 554 L ++LE R L+ Q++ ++ ++ +A R+ME ++D E E+ L Sbjct: 1580 LMLNE----EQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRL 1633 Score = 36.2 bits (82), Expect = 0.20 Identities = 100/577 (17%), Positives = 230/577 (39%), Gaps = 86/577 (14%) Query: 37 KSRQAVSRVSR-EELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERV 95 K Q + +S+ ++L+ + E + L+ + ++E +I R K + + + ++ Sbjct: 691 KQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQL 750 Query: 96 GGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQS 155 K + +M+E LQEK +LE +N LK+ K+ L+ TP + + Sbjct: 751 ----KTELLEKQMKEKENDLQEKFAQLEAENSILKDE----KKTLEDMLKIHTPVSQEER 802 Query: 156 RINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVI 215 I F D+ +++ ++ K L+EE Sbjct: 803 LI----------------------FLDSIKSKSKDSVWEKEIEILIEEN----------- 829 Query: 216 QSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQL 275 + + Q +L E + E E++ +L+E+ A ++D++E K +KQ Sbjct: 830 EDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYAC--LLKVKDDLEDSK-NKQE 886 Query: 276 VEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMK 335 +E + L A+ + + T+++ + + L+ + + + ++ Sbjct: 887 LEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946 Query: 336 FSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETA 395 ++R EL R++DL E LK+ + ++ +F + K +++Q+ ++ +LE Sbjct: 947 VTKREKLELSQRLSDLS---EQLKQKHGEI---SFLNEEVKSLKQEKEQVSLRCRELEII 1000 Query: 396 LKSDLTDKTEILD-RLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDI 454 + + + + D ++ + D + E + K K + +E+ I Sbjct: 1001 INHNRAENVQSCDTQVSSLLDGVVTMTSRGAE------------GSVSKVNKSFGEESKI 1048 Query: 455 NA-DELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTR 513 D++S + + + +Q+ L L V E L+AT +L+K Sbjct: 1049 MVEDKVSFENMTVGEESKQEQLILDHLPSVTKE---------SSLRATQPSENDKLQKEL 1099 Query: 514 NMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVH------LLDIRAARIHKLEA 567 N+L + D ++++EA + + + +V +Y+ L ++ I E Sbjct: 1100 NVLKSE---QNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEE 1156 Query: 568 QLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGE 604 ++K++ K ++ + + M + + +HL G+ Sbjct: 1157 KIKEL---QKIHQLELQTMKTQETGDEGKPLHLLIGK 1190 Score = 31.2 bits (69), Expect = 6.4 Identities = 65/343 (18%), Positives = 144/343 (41%), Gaps = 29/343 (8%) Query: 114 QLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQEC 173 +L+E+V ELE +L+ +L +Q + + + +Q R+ + +E+ Sbjct: 1335 KLEEQVQELESLISSLQQQLKETEQNYEAE------IHCLQKRL----QAVSESTVPPSL 1384 Query: 174 PRKGIKFQDADVAETPHP-MFTKYGNSLLEEARGE--IRNLENVIQSQRGQIEEL--EHL 228 P + ++D T +P K E GE ++ N+++ Q +E E + Sbjct: 1385 PVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEV 1444 Query: 229 AEILKTQLRRKENEIELSLLQ-LREQQATDQRSNIRDNVEMIKLHK-QLVEKSNALSAME 286 A+++ + + ELS + +E A+ ++++ E ++ +L + E Sbjct: 1445 AKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFE 1504 Query: 287 GKFIQLQEKQRTL-----RISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRI 341 ++ +E+ + L + L++N D ++ + + S E F R+ Sbjct: 1505 TVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQS 1564 Query: 342 EELQDRINDLEKERELLKENYDKLYD--SAFSAAHEEQWKLKEQQLKVQIAQLETAL--K 397 + ++ ++ R+L+ N ++L D ++E + E + + Q+E + Sbjct: 1565 IHDEISVSSMDASRQLML-NEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQ 1623 Query: 398 SDLTDKTEILDRLKTERD--QNEKLVQENRELQLQYLEQKQQL 438 L ++ + L+R +R NE LV E + L+ LE +QL Sbjct: 1624 EQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQL 1666 Score = 31.2 bits (69), Expect = 6.4 Identities = 54/278 (19%), Positives = 118/278 (42%), Gaps = 32/278 (11%) Query: 104 RDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRK 163 R+ E+ I L ++ ELE Q + LI K+Q++ + + ++ ++ Sbjct: 2593 REDELGSDISALTLRISELESQVVEMHTSLILEKEQVE---IAEKNVLEKEKKLLELQKL 2649 Query: 164 ANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNS----LLEEARGEIRNLENVIQSQR 219 N Q K QD +V +T +F S LE R E + + S + Sbjct: 2650 LEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYK 2709 Query: 220 GQIEELEH---LAEILKTQLRRKENEIELSLLQLREQQA---TDQRSNIRDNVEMIKLHK 273 + E+L+ + E T L++ +++ L + +E+ + + + ++++ + Sbjct: 2710 EKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEP 2769 Query: 274 QLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMAN-GDELNMQLKEQRLKCCSLEKQLH 332 ++ S ++++ +++ +T +I L+ N G ++N+Q + CS E+ Sbjct: 2770 LPIKLSKSIASQTDGTLKISSSNQTPQI----LVKNAGIQINLQSE------CSSEEVTE 2819 Query: 333 SMKFSERRIEELQD----RINDLE----KERELLKENY 362 + +IE++Q+ I D+E E E LK + Sbjct: 2820 IISQFTEKIEKMQELHAAEILDMESRHISETETLKREH 2857 >gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens] Length = 2003 Score = 78.2 bits (191), Expect = 5e-14 Identities = 101/387 (26%), Positives = 180/387 (46%), Gaps = 62/387 (16%) Query: 207 EIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNV 266 ++ + V+Q++ ++++++ L + Q R+ E++ + QL E++A +R Sbjct: 871 QVTRQDEVLQARAQELQKVQELQQ----QSAREVGELQGRVAQLEEERAR-LAEQLRAEA 925 Query: 267 EMI--------KLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLK 318 E+ +L + E +S +E + + +E R ++ L + EL L+ Sbjct: 926 ELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLE 985 Query: 319 EQRLKCCSLEKQLHSMKFSERRIEE----LQDRINDLEKERELLKENYDKLYDSAFSAAH 374 + L+ + + + ++ EE L+D+ + L KER+LL+ D+L + + AA Sbjct: 986 AEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLE---DRLAEFSSQAAE 1042 Query: 375 EEQW--KLKEQQLKVQ--IAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQ 430 EE+ L + +LK + IA +E L+ + + E L++LK D E+ ELQ Q Sbjct: 1043 EEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE-LEKLKRRLDG------ESSELQEQ 1095 Query: 431 YLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKD 490 +EQ+Q+ +EL R +L +E +EL AL A+ E + G + L+K Sbjct: 1096 MVEQQQRAEEL--RAQLGRKE-----EELQAAL----ARAEDEGGARAQLLK-------- 1136 Query: 491 LERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKME------NLQQDY 544 S+RE QA AE ++LE R K +D E+EA+ ++E N QQ+ Sbjct: 1137 ---SLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQEL 1193 Query: 545 ELKVEQYVHLLD---IRAARIHKLEAQ 568 K EQ V L RIH+ Q Sbjct: 1194 RSKREQEVTELKKTLEEETRIHEAAVQ 1220 Score = 69.7 bits (169), Expect = 2e-11 Identities = 108/489 (22%), Positives = 199/489 (40%), Gaps = 82/489 (16%) Query: 29 ETSTTRTMKSRQAVSRVSR------EELEDRFLRLHDENIL---LKQHARKQEDKIKRMA 79 E T R + + V R+ R +EL+D + L + L L++ RK + + Sbjct: 1427 EALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEK 1486 Query: 80 TKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQ 139 ++R V +++R E G +R R + + +E+ QE ELE+QN L+ L + Sbjct: 1487 AAVLRAVEERERAE--AEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSS 1544 Query: 140 LQTQGYRQTPYNNVQSRINTGRRKANE-NAGLQECPRKGIKFQDAD--VAETPHPMFTKY 196 G + ++ + AN+ A + E + +DA + T + T++ Sbjct: 1545 KDDVG---KSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQH 1601 Query: 197 GNSLL-EEARGEIRNLENVIQSQRGQIE----------------ELEHLAEILKTQLRRK 239 L + GE R + Q + ++E +LE E LK Q+ Sbjct: 1602 ERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASA 1661 Query: 240 ENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLV-----EKSNALSAMEGKFIQLQE 294 E ++ QLR+ QA Q + VE + ++ + E L +E + ++LQE Sbjct: 1662 GQGKEEAVKQLRKMQA--QMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQE 1719 Query: 295 KQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKE 354 + + + DE+ ++ L ++ L + E R+ +L++ + + + Sbjct: 1720 ELAASDRARRQAQQDRDEMADEVANGNLSKAAI---LEEKRQLEGRLGQLEEELEEEQSN 1776 Query: 355 RELLKENYDKLY------------DSAFSAAHEEQWKLKEQQLKVQIAQLE--------- 393 ELL + Y KL + +FSA E QQL+ QI +L Sbjct: 1777 SELLNDRYRKLLLQVESLTTELSAERSFSAKAES----GRQQLERQIQELRGRLGEEDAG 1832 Query: 394 ---------TALKSDLTDKTEILDRLKTERDQNEKLVQEN----RELQLQYLEQKQQLDE 440 AL+S L E L++ ER + KLV+ +E+ LQ E+++ D+ Sbjct: 1833 ARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQ 1892 Query: 441 LKKRIKLYN 449 L+ +++ N Sbjct: 1893 LRDQLEKGN 1901 Score = 62.4 bits (150), Expect = 3e-09 Identities = 125/628 (19%), Positives = 249/628 (39%), Gaps = 59/628 (9%) Query: 29 ETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVND 88 E + ++ + + ++ E+ L L D+N L + + ED++ +++ Sbjct: 987 EEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEK 1046 Query: 89 KKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQ- 147 K ++ RL + + +M ++L+ K + ++ E LK RL +LQ Q Q Sbjct: 1047 VKSLNKL-----RLKYEATIADMEDRLR-KEEKGRQELEKLKRRLDGESSELQEQMVEQQ 1100 Query: 148 -------TPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFT------ 194 + + +A + G + K ++ A +AE + + Sbjct: 1101 QRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVART 1160 Query: 195 ---KYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRR---KENEIELSLL 248 K L EE LE+ + S Q +EL E T+L++ +E I + + Sbjct: 1161 KAEKQRRDLGEELEALRGELEDTLDSTNAQ-QELRSKREQEVTELKKTLEEETRIHEAAV 1219 Query: 249 QLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMA 308 Q Q+ + + +E + K EK+ A+E + +L+ + +L+ + Sbjct: 1220 QELRQRHGQALGELAEQLEQARRGKGAWEKTRL--ALEAEVSELRAELSSLQTARQEGEQ 1277 Query: 309 NGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDS 368 L +QL+E + + E+ +R + + ++ E E K S Sbjct: 1278 RRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSS 1337 Query: 369 AFSAAHEEQWKLKEQ-QLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENREL 427 + H+ Q L+E+ + K+ + A++++ E L+ R+ + REL Sbjct: 1338 TEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARE------RAGREL 1391 Query: 428 QLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEI 487 Q + QL E ++R QE + A E E A++ + L+ + +E Sbjct: 1392 Q----TAQAQLSEWRRR-----QEEEAGALEAGEEARRRAAREAEA---LTQRLAEKTET 1439 Query: 488 NKDLERSMRELQATHAETVQELEKTRNMLI----MQHKINKDYQMEVEAVTRKMENLQQD 543 LER R LQ + +LE+ R ++ Q K ++ E AV R +E ++ Sbjct: 1440 VDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERA 1499 Query: 544 YELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIH-LER 602 E+ L + A + EA+ +++ + + + E + S D+ +++H LER Sbjct: 1500 EAEGREREARALSLTRALEEEQEAR-EELERQNRALRAELEALL-SSKDDVGKSVHELER 1557 Query: 603 GENLFEIHIN----KVTFSSEVLQASGD 626 + E N +VT + L A+ D Sbjct: 1558 ACRVAEQAANDLRAQVTELEDELTAAED 1585 Score = 62.4 bits (150), Expect = 3e-09 Identities = 125/662 (18%), Positives = 254/662 (38%), Gaps = 107/662 (16%) Query: 48 EELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVE 107 +EL +LHD LL++ R + R+ +++ E +R GR+++ Sbjct: 1333 KELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQ 1392 Query: 108 -----MEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRR 162 + E + +E+ LE E + A ++ + R R+ GRR Sbjct: 1393 TAQAQLSEWRRRQEEEAGALEAGEEARRR----AAREAEALTQRLAEKTETVDRLERGRR 1448 Query: 163 KANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQI 222 + + + Q + T K+ L EE +R +E + +R + Sbjct: 1449 RLQQELDDATMDLE----QQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVE---ERERAEA 1501 Query: 223 EELEHLAEIL-------KTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIK----- 270 E E A L + Q R+E E + L+ + + ++ +V ++ Sbjct: 1502 EGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRV 1561 Query: 271 -------LHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQ--- 320 L Q+ E + L+A E ++L+ + L+ H+ + DE + + Q Sbjct: 1562 AEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAK 1621 Query: 321 RLKCCSLEKQ---------LHSMKFSERRIEEL-----------QDRINDLEKERELLKE 360 +L+ +E+ + + K E +EEL ++ + L K + +KE Sbjct: 1622 QLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKE 1681 Query: 361 NYDKLYDSA------FSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTER 414 + ++ ++ FS E + +LK + +V L+ +L + + +R Sbjct: 1682 LWREVEETRTSREEIFSQNRESEKRLKGLEAEV------LRLQEELAASDRARRQAQQDR 1735 Query: 415 DQNEKLVQENRELQLQYLEQKQQLD----ELKKRIKLYNQENDINADELSEALLLIKAQK 470 D+ V + LE+K+QL+ +L++ ++ +++ D + LL +++ Sbjct: 1736 DEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLT 1795 Query: 471 EQKNGDLSFLVKVDSEINKDLERSMREL-----------QATHAETVQELEKTRNMLIMQ 519 + + + SF K +S + LER ++EL +A H T+ LE Q Sbjct: 1796 TELSAERSFSAKAESG-RQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQ 1854 Query: 520 HKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQY 579 + ++ + R+ E ++ L+VE+ + D +L QL+ KQ Sbjct: 1855 LEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVAD-------QLRDQLEKGNLRVKQL 1907 Query: 580 KFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSE-------VLQASGDKEPVTF 632 K + E + +E + G + + VT S+E L+ + P+TF Sbjct: 1908 KRQLE-------EAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTF 1960 Query: 633 CT 634 T Sbjct: 1961 TT 1962 >gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens] Length = 1995 Score = 78.2 bits (191), Expect = 5e-14 Identities = 101/387 (26%), Positives = 180/387 (46%), Gaps = 62/387 (16%) Query: 207 EIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNV 266 ++ + V+Q++ ++++++ L + Q R+ E++ + QL E++A +R Sbjct: 863 QVTRQDEVLQARAQELQKVQELQQ----QSAREVGELQGRVAQLEEERAR-LAEQLRAEA 917 Query: 267 EMI--------KLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLK 318 E+ +L + E +S +E + + +E R ++ L + EL L+ Sbjct: 918 ELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLE 977 Query: 319 EQRLKCCSLEKQLHSMKFSERRIEE----LQDRINDLEKERELLKENYDKLYDSAFSAAH 374 + L+ + + + ++ EE L+D+ + L KER+LL+ D+L + + AA Sbjct: 978 AEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLE---DRLAEFSSQAAE 1034 Query: 375 EEQW--KLKEQQLKVQ--IAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQ 430 EE+ L + +LK + IA +E L+ + + E L++LK D E+ ELQ Q Sbjct: 1035 EEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE-LEKLKRRLDG------ESSELQEQ 1087 Query: 431 YLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKD 490 +EQ+Q+ +EL R +L +E +EL AL A+ E + G + L+K Sbjct: 1088 MVEQQQRAEEL--RAQLGRKE-----EELQAAL----ARAEDEGGARAQLLK-------- 1128 Query: 491 LERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKME------NLQQDY 544 S+RE QA AE ++LE R K +D E+EA+ ++E N QQ+ Sbjct: 1129 ---SLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQEL 1185 Query: 545 ELKVEQYVHLLD---IRAARIHKLEAQ 568 K EQ V L RIH+ Q Sbjct: 1186 RSKREQEVTELKKTLEEETRIHEAAVQ 1212 Score = 69.7 bits (169), Expect = 2e-11 Identities = 108/489 (22%), Positives = 199/489 (40%), Gaps = 82/489 (16%) Query: 29 ETSTTRTMKSRQAVSRVSR------EELEDRFLRLHDENIL---LKQHARKQEDKIKRMA 79 E T R + + V R+ R +EL+D + L + L L++ RK + + Sbjct: 1419 EALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEK 1478 Query: 80 TKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQ 139 ++R V +++R E G +R R + + +E+ QE ELE+QN L+ L + Sbjct: 1479 AAVLRAVEERERAE--AEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSS 1536 Query: 140 LQTQGYRQTPYNNVQSRINTGRRKANE-NAGLQECPRKGIKFQDAD--VAETPHPMFTKY 196 G + ++ + AN+ A + E + +DA + T + T++ Sbjct: 1537 KDDVG---KSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQH 1593 Query: 197 GNSLL-EEARGEIRNLENVIQSQRGQIE----------------ELEHLAEILKTQLRRK 239 L + GE R + Q + ++E +LE E LK Q+ Sbjct: 1594 ERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASA 1653 Query: 240 ENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLV-----EKSNALSAMEGKFIQLQE 294 E ++ QLR+ QA Q + VE + ++ + E L +E + ++LQE Sbjct: 1654 GQGKEEAVKQLRKMQA--QMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQE 1711 Query: 295 KQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKE 354 + + + DE+ ++ L ++ L + E R+ +L++ + + + Sbjct: 1712 ELAASDRARRQAQQDRDEMADEVANGNLSKAAI---LEEKRQLEGRLGQLEEELEEEQSN 1768 Query: 355 RELLKENYDKLY------------DSAFSAAHEEQWKLKEQQLKVQIAQLE--------- 393 ELL + Y KL + +FSA E QQL+ QI +L Sbjct: 1769 SELLNDRYRKLLLQVESLTTELSAERSFSAKAES----GRQQLERQIQELRGRLGEEDAG 1824 Query: 394 ---------TALKSDLTDKTEILDRLKTERDQNEKLVQEN----RELQLQYLEQKQQLDE 440 AL+S L E L++ ER + KLV+ +E+ LQ E+++ D+ Sbjct: 1825 ARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQ 1884 Query: 441 LKKRIKLYN 449 L+ +++ N Sbjct: 1885 LRDQLEKGN 1893 Score = 62.4 bits (150), Expect = 3e-09 Identities = 125/628 (19%), Positives = 249/628 (39%), Gaps = 59/628 (9%) Query: 29 ETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVND 88 E + ++ + + ++ E+ L L D+N L + + ED++ +++ Sbjct: 979 EEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEK 1038 Query: 89 KKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQ- 147 K ++ RL + + +M ++L+ K + ++ E LK RL +LQ Q Q Sbjct: 1039 VKSLNKL-----RLKYEATIADMEDRLR-KEEKGRQELEKLKRRLDGESSELQEQMVEQQ 1092 Query: 148 -------TPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFT------ 194 + + +A + G + K ++ A +AE + + Sbjct: 1093 QRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVART 1152 Query: 195 ---KYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRR---KENEIELSLL 248 K L EE LE+ + S Q +EL E T+L++ +E I + + Sbjct: 1153 KAEKQRRDLGEELEALRGELEDTLDSTNAQ-QELRSKREQEVTELKKTLEEETRIHEAAV 1211 Query: 249 QLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMA 308 Q Q+ + + +E + K EK+ A+E + +L+ + +L+ + Sbjct: 1212 QELRQRHGQALGELAEQLEQARRGKGAWEKTRL--ALEAEVSELRAELSSLQTARQEGEQ 1269 Query: 309 NGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDS 368 L +QL+E + + E+ +R + + ++ E E K S Sbjct: 1270 RRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSS 1329 Query: 369 AFSAAHEEQWKLKEQ-QLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENREL 427 + H+ Q L+E+ + K+ + A++++ E L+ R+ + REL Sbjct: 1330 TEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARE------RAGREL 1383 Query: 428 QLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEI 487 Q + QL E ++R QE + A E E A++ + L+ + +E Sbjct: 1384 Q----TAQAQLSEWRRR-----QEEEAGALEAGEEARRRAAREAEA---LTQRLAEKTET 1431 Query: 488 NKDLERSMRELQATHAETVQELEKTRNMLI----MQHKINKDYQMEVEAVTRKMENLQQD 543 LER R LQ + +LE+ R ++ Q K ++ E AV R +E ++ Sbjct: 1432 VDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERA 1491 Query: 544 YELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIH-LER 602 E+ L + A + EA+ +++ + + + E + S D+ +++H LER Sbjct: 1492 EAEGREREARALSLTRALEEEQEAR-EELERQNRALRAELEALL-SSKDDVGKSVHELER 1549 Query: 603 GENLFEIHIN----KVTFSSEVLQASGD 626 + E N +VT + L A+ D Sbjct: 1550 ACRVAEQAANDLRAQVTELEDELTAAED 1577 Score = 62.4 bits (150), Expect = 3e-09 Identities = 125/662 (18%), Positives = 254/662 (38%), Gaps = 107/662 (16%) Query: 48 EELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVE 107 +EL +LHD LL++ R + R+ +++ E +R GR+++ Sbjct: 1325 KELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQ 1384 Query: 108 -----MEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRR 162 + E + +E+ LE E + A ++ + R R+ GRR Sbjct: 1385 TAQAQLSEWRRRQEEEAGALEAGEEARRR----AAREAEALTQRLAEKTETVDRLERGRR 1440 Query: 163 KANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQI 222 + + + Q + T K+ L EE +R +E + +R + Sbjct: 1441 RLQQELDDATMDLE----QQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVE---ERERAEA 1493 Query: 223 EELEHLAEIL-------KTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIK----- 270 E E A L + Q R+E E + L+ + + ++ +V ++ Sbjct: 1494 EGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRV 1553 Query: 271 -------LHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQ--- 320 L Q+ E + L+A E ++L+ + L+ H+ + DE + + Q Sbjct: 1554 AEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAK 1613 Query: 321 RLKCCSLEKQ---------LHSMKFSERRIEEL-----------QDRINDLEKERELLKE 360 +L+ +E+ + + K E +EEL ++ + L K + +KE Sbjct: 1614 QLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKE 1673 Query: 361 NYDKLYDSA------FSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTER 414 + ++ ++ FS E + +LK + +V L+ +L + + +R Sbjct: 1674 LWREVEETRTSREEIFSQNRESEKRLKGLEAEV------LRLQEELAASDRARRQAQQDR 1727 Query: 415 DQNEKLVQENRELQLQYLEQKQQLD----ELKKRIKLYNQENDINADELSEALLLIKAQK 470 D+ V + LE+K+QL+ +L++ ++ +++ D + LL +++ Sbjct: 1728 DEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLT 1787 Query: 471 EQKNGDLSFLVKVDSEINKDLERSMREL-----------QATHAETVQELEKTRNMLIMQ 519 + + + SF K +S + LER ++EL +A H T+ LE Q Sbjct: 1788 TELSAERSFSAKAESG-RQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQ 1846 Query: 520 HKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQY 579 + ++ + R+ E ++ L+VE+ + D +L QL+ KQ Sbjct: 1847 LEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVAD-------QLRDQLEKGNLRVKQL 1899 Query: 580 KFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSE-------VLQASGDKEPVTF 632 K + E + +E + G + + VT S+E L+ + P+TF Sbjct: 1900 KRQLE-------EAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTF 1952 Query: 633 CT 634 T Sbjct: 1953 TT 1954 >gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens] Length = 2036 Score = 78.2 bits (191), Expect = 5e-14 Identities = 101/387 (26%), Positives = 180/387 (46%), Gaps = 62/387 (16%) Query: 207 EIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNV 266 ++ + V+Q++ ++++++ L + Q R+ E++ + QL E++A +R Sbjct: 904 QVTRQDEVLQARAQELQKVQELQQ----QSAREVGELQGRVAQLEEERAR-LAEQLRAEA 958 Query: 267 EMI--------KLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLK 318 E+ +L + E +S +E + + +E R ++ L + EL L+ Sbjct: 959 ELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLE 1018 Query: 319 EQRLKCCSLEKQLHSMKFSERRIEE----LQDRINDLEKERELLKENYDKLYDSAFSAAH 374 + L+ + + + ++ EE L+D+ + L KER+LL+ D+L + + AA Sbjct: 1019 AEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLE---DRLAEFSSQAAE 1075 Query: 375 EEQW--KLKEQQLKVQ--IAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQ 430 EE+ L + +LK + IA +E L+ + + E L++LK D E+ ELQ Q Sbjct: 1076 EEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE-LEKLKRRLDG------ESSELQEQ 1128 Query: 431 YLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKD 490 +EQ+Q+ +EL R +L +E +EL AL A+ E + G + L+K Sbjct: 1129 MVEQQQRAEEL--RAQLGRKE-----EELQAAL----ARAEDEGGARAQLLK-------- 1169 Query: 491 LERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKME------NLQQDY 544 S+RE QA AE ++LE R K +D E+EA+ ++E N QQ+ Sbjct: 1170 ---SLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQEL 1226 Query: 545 ELKVEQYVHLLD---IRAARIHKLEAQ 568 K EQ V L RIH+ Q Sbjct: 1227 RSKREQEVTELKKTLEEETRIHEAAVQ 1253 Score = 69.7 bits (169), Expect = 2e-11 Identities = 108/489 (22%), Positives = 199/489 (40%), Gaps = 82/489 (16%) Query: 29 ETSTTRTMKSRQAVSRVSR------EELEDRFLRLHDENIL---LKQHARKQEDKIKRMA 79 E T R + + V R+ R +EL+D + L + L L++ RK + + Sbjct: 1460 EALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEK 1519 Query: 80 TKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQ 139 ++R V +++R E G +R R + + +E+ QE ELE+QN L+ L + Sbjct: 1520 AAVLRAVEERERAE--AEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSS 1577 Query: 140 LQTQGYRQTPYNNVQSRINTGRRKANE-NAGLQECPRKGIKFQDAD--VAETPHPMFTKY 196 G + ++ + AN+ A + E + +DA + T + T++ Sbjct: 1578 KDDVG---KSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQH 1634 Query: 197 GNSLL-EEARGEIRNLENVIQSQRGQIE----------------ELEHLAEILKTQLRRK 239 L + GE R + Q + ++E +LE E LK Q+ Sbjct: 1635 ERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASA 1694 Query: 240 ENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLV-----EKSNALSAMEGKFIQLQE 294 E ++ QLR+ QA Q + VE + ++ + E L +E + ++LQE Sbjct: 1695 GQGKEEAVKQLRKMQA--QMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQE 1752 Query: 295 KQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKE 354 + + + DE+ ++ L ++ L + E R+ +L++ + + + Sbjct: 1753 ELAASDRARRQAQQDRDEMADEVANGNLSKAAI---LEEKRQLEGRLGQLEEELEEEQSN 1809 Query: 355 RELLKENYDKLY------------DSAFSAAHEEQWKLKEQQLKVQIAQLE--------- 393 ELL + Y KL + +FSA E QQL+ QI +L Sbjct: 1810 SELLNDRYRKLLLQVESLTTELSAERSFSAKAES----GRQQLERQIQELRGRLGEEDAG 1865 Query: 394 ---------TALKSDLTDKTEILDRLKTERDQNEKLVQEN----RELQLQYLEQKQQLDE 440 AL+S L E L++ ER + KLV+ +E+ LQ E+++ D+ Sbjct: 1866 ARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQ 1925 Query: 441 LKKRIKLYN 449 L+ +++ N Sbjct: 1926 LRDQLEKGN 1934 Score = 62.4 bits (150), Expect = 3e-09 Identities = 125/628 (19%), Positives = 249/628 (39%), Gaps = 59/628 (9%) Query: 29 ETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVND 88 E + ++ + + ++ E+ L L D+N L + + ED++ +++ Sbjct: 1020 EEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEK 1079 Query: 89 KKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQ- 147 K ++ RL + + +M ++L+ K + ++ E LK RL +LQ Q Q Sbjct: 1080 VKSLNKL-----RLKYEATIADMEDRLR-KEEKGRQELEKLKRRLDGESSELQEQMVEQQ 1133 Query: 148 -------TPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFT------ 194 + + +A + G + K ++ A +AE + + Sbjct: 1134 QRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVART 1193 Query: 195 ---KYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRR---KENEIELSLL 248 K L EE LE+ + S Q +EL E T+L++ +E I + + Sbjct: 1194 KAEKQRRDLGEELEALRGELEDTLDSTNAQ-QELRSKREQEVTELKKTLEEETRIHEAAV 1252 Query: 249 QLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMA 308 Q Q+ + + +E + K EK+ A+E + +L+ + +L+ + Sbjct: 1253 QELRQRHGQALGELAEQLEQARRGKGAWEKTRL--ALEAEVSELRAELSSLQTARQEGEQ 1310 Query: 309 NGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDS 368 L +QL+E + + E+ +R + + ++ E E K S Sbjct: 1311 RRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSS 1370 Query: 369 AFSAAHEEQWKLKEQ-QLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENREL 427 + H+ Q L+E+ + K+ + A++++ E L+ R+ + REL Sbjct: 1371 TEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARE------RAGREL 1424 Query: 428 QLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEI 487 Q + QL E ++R QE + A E E A++ + L+ + +E Sbjct: 1425 Q----TAQAQLSEWRRR-----QEEEAGALEAGEEARRRAAREAEA---LTQRLAEKTET 1472 Query: 488 NKDLERSMRELQATHAETVQELEKTRNMLI----MQHKINKDYQMEVEAVTRKMENLQQD 543 LER R LQ + +LE+ R ++ Q K ++ E AV R +E ++ Sbjct: 1473 VDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERA 1532 Query: 544 YELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIH-LER 602 E+ L + A + EA+ +++ + + + E + S D+ +++H LER Sbjct: 1533 EAEGREREARALSLTRALEEEQEAR-EELERQNRALRAELEALL-SSKDDVGKSVHELER 1590 Query: 603 GENLFEIHIN----KVTFSSEVLQASGD 626 + E N +VT + L A+ D Sbjct: 1591 ACRVAEQAANDLRAQVTELEDELTAAED 1618 Score = 62.4 bits (150), Expect = 3e-09 Identities = 125/662 (18%), Positives = 254/662 (38%), Gaps = 107/662 (16%) Query: 48 EELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVE 107 +EL +LHD LL++ R + R+ +++ E +R GR+++ Sbjct: 1366 KELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQ 1425 Query: 108 -----MEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRR 162 + E + +E+ LE E + A ++ + R R+ GRR Sbjct: 1426 TAQAQLSEWRRRQEEEAGALEAGEEARRR----AAREAEALTQRLAEKTETVDRLERGRR 1481 Query: 163 KANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQI 222 + + + Q + T K+ L EE +R +E + +R + Sbjct: 1482 RLQQELDDATMDLE----QQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVE---ERERAEA 1534 Query: 223 EELEHLAEIL-------KTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIK----- 270 E E A L + Q R+E E + L+ + + ++ +V ++ Sbjct: 1535 EGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRV 1594 Query: 271 -------LHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQ--- 320 L Q+ E + L+A E ++L+ + L+ H+ + DE + + Q Sbjct: 1595 AEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAK 1654 Query: 321 RLKCCSLEKQ---------LHSMKFSERRIEEL-----------QDRINDLEKERELLKE 360 +L+ +E+ + + K E +EEL ++ + L K + +KE Sbjct: 1655 QLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKE 1714 Query: 361 NYDKLYDSA------FSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTER 414 + ++ ++ FS E + +LK + +V L+ +L + + +R Sbjct: 1715 LWREVEETRTSREEIFSQNRESEKRLKGLEAEV------LRLQEELAASDRARRQAQQDR 1768 Query: 415 DQNEKLVQENRELQLQYLEQKQQLD----ELKKRIKLYNQENDINADELSEALLLIKAQK 470 D+ V + LE+K+QL+ +L++ ++ +++ D + LL +++ Sbjct: 1769 DEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLT 1828 Query: 471 EQKNGDLSFLVKVDSEINKDLERSMREL-----------QATHAETVQELEKTRNMLIMQ 519 + + + SF K +S + LER ++EL +A H T+ LE Q Sbjct: 1829 TELSAERSFSAKAESG-RQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQ 1887 Query: 520 HKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQY 579 + ++ + R+ E ++ L+VE+ + D +L QL+ KQ Sbjct: 1888 LEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVAD-------QLRDQLEKGNLRVKQL 1940 Query: 580 KFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSE-------VLQASGDKEPVTF 632 K + E + +E + G + + VT S+E L+ + P+TF Sbjct: 1941 KRQLE-------EAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTF 1993 Query: 633 CT 634 T Sbjct: 1994 TT 1995 >gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens] Length = 1976 Score = 78.2 bits (191), Expect = 5e-14 Identities = 143/666 (21%), Positives = 265/666 (39%), Gaps = 141/666 (21%) Query: 28 QETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVN 87 +E + ++ + + +++E+ L L D+N + + ED+I +++L Sbjct: 961 EEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEE 1020 Query: 88 DKKRYERVGGGPKRLGRDVE----MEEMIEQ---------------LQEKVHELEKQNET 128 K ++ + + D+E EE Q LQ+++ EL+ Q + Sbjct: 1021 KAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDE 1080 Query: 129 LKNRLISAKQQLQ---TQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADV 185 LK +L +++LQ +G +T + N + + R + A LQE D + Sbjct: 1081 LKLQLAKKEEELQGALARGDDETLHKN--NALKVVRELQAQIAELQE---------DFES 1129 Query: 186 AETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIE---ELEHLAEILKTQLRRKENE 242 + K L EE LE+ + + Q E + E LK L + Sbjct: 1130 EKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKN 1189 Query: 243 IELSLLQLREQQAT---------DQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQ-- 291 E + +R++ AT +Q + N+E +KQ +E N A E K +Q Sbjct: 1190 HEAQIQDMRQRHATALEELSEQLEQAKRFKANLEK---NKQGLETDNKELACEVKVLQQV 1246 Query: 292 ---LQEKQRTLRISHDAL---MANGDELNMQLKEQRLK---------------------- 323 + K++ L L ++ GD L ++L E+ K Sbjct: 1247 KAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKF 1306 Query: 324 ---CCSLEKQLHS----MKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEE 376 SLE QL ++ R+ L RI LE+E+ L+E ++ ++ + + Sbjct: 1307 AKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQV 1366 Query: 377 ---QWKLKEQQLKVQ-----IAQLETALKSDLTDKTEILDRL--------KTERDQNEKL 420 Q +L + + KV I LE A K L D + RL K E+ +N +L Sbjct: 1367 LALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKN-RL 1425 Query: 421 VQENRELQLQYLEQKQQLDELKKRIKLYNQ----ENDINA--------------DELSEA 462 QE +L + Q+Q L+K+ K ++Q E I+A ++ ++A Sbjct: 1426 QQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKA 1485 Query: 463 LLLIKA-------------QKEQKNGDLSFLVKVDSEINK---DLERSMRELQATHAETV 506 L L +A Q +Q D+ L+ ++ K +LE+S R L+ E Sbjct: 1486 LSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMR 1545 Query: 507 QELEKTRNMLIMQHKINKDYQMEVEAVTRKME-NLQQDYELKVEQYVHLLDIRAARIHKL 565 +LE+ + L + +D ++ +E + M+ ++D + + EQ + ++ +L Sbjct: 1546 TQLEELEDEL----QATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVREL 1601 Query: 566 EAQLKD 571 EA+L+D Sbjct: 1602 EAELED 1607 Score = 77.0 bits (188), Expect = 1e-13 Identities = 117/523 (22%), Positives = 224/523 (42%), Gaps = 86/523 (16%) Query: 56 RLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVE-MEEMIEQ 114 R +E + AR++E K +A L + K+ +ER K+L D+E + + Sbjct: 1466 RYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQN---KQLRADMEDLMSSKDD 1522 Query: 115 LQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQ-EC 173 + + VHELEK L+ ++ + QL+ ++ + +A E+A L+ E Sbjct: 1523 VGKNVHELEKSKRALEQQVEEMRTQLE----------ELEDEL-----QATEDAKLRLEV 1567 Query: 174 PRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILK 233 + +K Q E +Q++ Q EE + L Sbjct: 1568 NMQAMKAQ-----------------------------FERDLQTRDEQNEEKKRL----- 1593 Query: 234 TQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQ 293 L ++ E+E L R+Q+A S + +++ L Q+ + A + + +LQ Sbjct: 1594 --LIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQ 1651 Query: 294 EKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEK 353 + + + + A+ DE+ Q KE EK+L S+ E I +LQ+ + E+ Sbjct: 1652 AQMKDYQRELEEARASRDEIFAQSKES-------EKKLKSL---EAEILQLQEELASSER 1701 Query: 354 ERELLKENYDKLYDSAFSAAHEEQWKLKE-QQLKVQIAQLETALKSDLTDKTEILDRLKT 412 R ++ D+L D ++A + L E ++L+ +IAQLE L+ + ++ + DR + Sbjct: 1702 ARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRK 1761 Query: 413 ERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQ 472 Q + L N EL + Q+ D +++++ N+E EL A+ K + Sbjct: 1762 TTLQVDTL---NAELAAE-RSAAQKSDNARQQLERQNKELKAKLQELEGAV------KSK 1811 Query: 473 KNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINK----DYQM 528 +S L ++ + LE+ +E A + + V+ EK + MQ + + Y+ Sbjct: 1812 FKATISALEAKIGQLEEQLEQEAKERAAAN-KLVRRTEKKLKEIFMQVEDERRHADQYKE 1870 Query: 529 EVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKD 571 ++E +M+ L++ E E+ A+R KL+ +L D Sbjct: 1871 QMEKANARMKQLKRQLEEAEEEATR---ANASR-RKLQRELDD 1909 Score = 74.3 bits (181), Expect = 7e-13 Identities = 114/521 (21%), Positives = 213/521 (40%), Gaps = 83/521 (15%) Query: 101 RLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQL-----QTQGYRQTPYNNVQS 155 R R+ E+ E+ + L+E+ E Q + ++ R +A ++L Q + ++ N Q Sbjct: 1169 RTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQG 1228 Query: 156 RINTGRRKANENAGLQECPRKGI---KFQDADVAETPHPMFTKYGNSLLEEARGEIRNLE 212 + A E LQ+ + K DA V E H ++ G+ L E + L+ Sbjct: 1229 LETDNKELACEVKVLQQVKAESEHKRKKLDAQVQEL-HAKVSE-GDRLRVELAEKASKLQ 1286 Query: 213 NVIQSQRGQIEE------------------LEHLAEILKTQLRRKEN------EIELSLL 248 N + + +EE L+ E+L+ + R+K N ++E Sbjct: 1287 NELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKN 1346 Query: 249 QLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMA 308 L+EQQ ++ + +++ L QL + + G L+E ++ L + Sbjct: 1347 SLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKL-------LK 1399 Query: 309 NGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLK--ENYDKLY 366 + + L+ +L+E+ L LEK + ++ +EL D DL+ +R++ E K + Sbjct: 1400 DAEALSQRLEEKALAYDKLEKTKNRLQ------QELDDLTVDLDHQRQVASNLEKKQKKF 1453 Query: 367 D---------SAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQN 417 D SA A ++ + + ++ + + L AL+ L K E + K R Sbjct: 1454 DQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADM 1513 Query: 418 EKLVQEN-------RELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQK 470 E L+ EL+ +QQ++E++ +++ E D + ++A K Sbjct: 1514 EDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMK 1573 Query: 471 EQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEV 530 Q DL + + E + L + +REL+A ELE R + Sbjct: 1574 AQFERDLQTRDEQNEEKKRLLIKQVRELEA-------ELEDERKQRAL-----------A 1615 Query: 531 EAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKD 571 A +KME +D E ++E D ++ KL+AQ+KD Sbjct: 1616 VASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKD 1656 Score = 67.8 bits (164), Expect = 6e-11 Identities = 119/552 (21%), Positives = 230/552 (41%), Gaps = 80/552 (14%) Query: 44 RVSREELEDRFLRLHDENIL-LKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRL 102 +V+R+E E L+ DE +L +K+ K E +++ M K +L+ +K L Sbjct: 846 QVTRQEEE---LQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETEL 902 Query: 103 GRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRR 162 E EEM +L K ELE+ L++R+ +++ Q Q +Q+ I Sbjct: 903 F--AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQ---ILQNEKKKMQAHIQDLEE 957 Query: 163 KANENAGLQE-------CPRKGIKFQDADV--AETPHPMFTKYG----------NSLLEE 203 + +E G ++ IK + ++ E + F K +S L E Sbjct: 958 QLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAE 1017 Query: 204 ARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIR 263 + +NL + Q I +LE + K + R+E E L DQ + ++ Sbjct: 1018 EEEKAKNLAKIRNKQEVMISDLEE--RLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQ 1075 Query: 264 DNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLK 323 ++ +KL QL +K +E Q L D + + L + ++E + + Sbjct: 1076 AQIDELKL--QLAKKE-------------EELQGALARGDDETLHKNNALKV-VRELQAQ 1119 Query: 324 CCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQ 383 L++ S K S + E+ + DL +E E LK +L D+ + A +++ + K + Sbjct: 1120 IAELQEDFESEKASRNKAEKQK---RDLSEELEALK---TELEDTLDTTAAQQELRTKRE 1173 Query: 384 QLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKK 443 Q ++A+L+ AL+ E +E +Q+ R+ LE+ + E K Sbjct: 1174 Q---EVAELKKALEE--------------ETKNHEAQIQDMRQRHATALEELSEQLEQAK 1216 Query: 444 RIKLYNQEN----DINADELS---EALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMR 496 R K ++N + + EL+ + L +KA+ E K L V+ + +R Sbjct: 1217 RFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRV 1276 Query: 497 ELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLD 556 EL ++ EL+ +L K + + ++ ++++ Q+ + + Q ++L Sbjct: 1277 ELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNL-- 1334 Query: 557 IRAARIHKLEAQ 568 ++RI +LE + Sbjct: 1335 --SSRIRQLEEE 1344 Score = 64.3 bits (155), Expect = 7e-10 Identities = 96/430 (22%), Positives = 188/430 (43%), Gaps = 71/430 (16%) Query: 201 LEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQ-QATDQR 259 +E ++ +N++ Q EL AE ++ +L K+ E+E L L + + ++R Sbjct: 878 MERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEER 937 Query: 260 SNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRT----LRISHDALMANGDELNM 315 + I N E K+ + + L EG +LQ ++ T ++ + ++ D+ + Sbjct: 938 NQILQN-EKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSK 996 Query: 316 QLKEQRL------KCCSL-----EKQLHSMKFSERR---IEELQDRINDLEKERELLKEN 361 +KE++L +C S EK + K ++ I +L++R+ EK R+ L++ Sbjct: 997 FIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKA 1056 Query: 362 YDKLYDSAFSAAHEEQWKLKEQ--QLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEK 419 KL D + ++ +L+ Q +LK+Q+A+ E L+ L R +E Sbjct: 1057 KRKL-DGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALA------------RGDDET 1103 Query: 420 LVQEN-----RELQLQYLEQKQQLD-ELKKRIKLYNQENDINAD------ELSEALLLIK 467 L + N RELQ Q E ++ + E R K Q+ D++ + EL + L Sbjct: 1104 LHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTA 1163 Query: 468 AQKE---QKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQE---------------- 508 AQ+E ++ +++ L K E K+ E +++++ HA ++E Sbjct: 1164 AQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLE 1223 Query: 509 -----LEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIH 563 LE L + K+ + + E E +K++ Q+ KV + L A + Sbjct: 1224 KNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKAS 1283 Query: 564 KLEAQLKDIA 573 KL+ +L +++ Sbjct: 1284 KLQNELDNVS 1293 >gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens] Length = 2230 Score = 78.2 bits (191), Expect = 5e-14 Identities = 124/578 (21%), Positives = 250/578 (43%), Gaps = 94/578 (16%) Query: 58 HDENILLKQH----ARKQEDKIKRMATKLIRLVND-----------KKRYERVGGGPKRL 102 H E + QH ++++++K K++ L N KK E V K Sbjct: 1559 HKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSK 1618 Query: 103 GRDVE-MEEMIE-----QLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSR 156 +++ +E+ +E +L E + E++ +K +L+S ++ + Q Y++ +++ S Sbjct: 1619 EEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQ-YKKGTESHL-SE 1676 Query: 157 INTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEA--RGEIRNL--E 212 +NT ++ + E K ++ ++ P + EEA +G ++ E Sbjct: 1677 LNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEE 1736 Query: 213 NVIQSQRGQIEELEHLAEILKTQLRRKENEIELS------LLQLREQQATDQRSNIRDNV 266 + QR E+ + L + + + + E+ L++L +A D Sbjct: 1737 KISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHE----DQS 1792 Query: 267 EMIKLHKQLVEKSNALSAMEGKFIQ-------LQEKQRTLRISHDALMANGD-ELNMQLK 318 + L ++L EK+ S + + ++ +Q KQ + D + EL Q+ Sbjct: 1793 MIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQIL 1852 Query: 319 EQRLK----CCSLEKQLHSMKFSE--RRIEELQ--DRINDLEKERELLKENYDKLYDSAF 370 EQ++K C +K++H ++ E + E+LQ +++ K ELL+EN ++ Sbjct: 1853 EQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEK----- 1907 Query: 371 SAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQ 430 S +H Q KL ++ Q LE L +K ++ +++V+ ++L++ Sbjct: 1908 SKSHLVQPKLLSN-MEAQHNDLEFKLAGAEREKQKL----------GKEIVRLQKDLRML 1956 Query: 431 YLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKD 490 E +Q+L+ LKK Y+QE + + E L L + N L L++ E N Sbjct: 1957 RKEHQQELEILKKE---YDQEREEKIKQEQEDLEL------KHNSTLKQLMR---EFNTQ 2004 Query: 491 LERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQ 550 L + +EL+ T ET+ + ++ L+ H Q E + +K+ D + ++ Sbjct: 2005 LAQKEQELEMTIKETINKAQEVEAELLESH------QEETNQLLKKIAEKDDDLKRTAKR 2058 Query: 551 YVHLLDIR----AARIHKLEAQLKDIAYGTKQYKFKPE 584 Y +LD R A++ L+ QL+++ K+Y+ K E Sbjct: 2059 YEEILDAREEEMTAKVRDLQTQLEEL---QKKYQQKLE 2093 Score = 75.1 bits (183), Expect = 4e-13 Identities = 110/522 (21%), Positives = 236/522 (45%), Gaps = 79/522 (15%) Query: 104 RDVEMEEMIEQLQEKV---HELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTG 160 + E+E + +L E + H+LE++ LK++ KQ+L+ + Q N+ Q ++++ Sbjct: 682 KQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQK--NHHQQQVDSI 739 Query: 161 RRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRG 220 ++ + E K +K Q + + K + L+E + + NLE I+ G Sbjct: 740 IKEHEVSIQRTE---KALKDQINQLE-----LLLKERDKHLKEHQAHVENLEADIKRSEG 791 Query: 221 QIEELEHLAEILK-----TQLRRKENEIELSLLQ-----------LREQQATDQRSNIRD 264 ++++ ++ + T + K E +L+ LQ L +Q + + +D Sbjct: 792 ELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKD 851 Query: 265 NVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKE----- 319 + HK ++ + + +E + ++++K ++L +++ + +G++ Q K+ Sbjct: 852 VCTELDAHK--IQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEK 909 Query: 320 QRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWK 379 + + E Q ++ +++ +D I+ L +E E +N +K + A E Q Sbjct: 910 ENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQET 969 Query: 380 LK----EQQLKVQIAQLETALKSDLTDK-----------------TEILDRLKT-ERDQN 417 LK +Q+ K++ TAL+ +K ++ + RL+T +++Q Sbjct: 970 LKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQI 1029 Query: 418 EKLVQ-ENRELQ--LQYLEQK--QQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQ 472 E L + REL + E+K QQ +EL++ ++ QE + EL + +LL +KE+ Sbjct: 1030 ESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEE 1089 Query: 473 KNGDLSFL----VKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQM 528 N ++++L VK D+ +N +L+ +++ A Q+ K + L K+ D Sbjct: 1090 MNKEITWLKEEGVKQDTTLN-ELQEQLKQKSAHVNSLAQDETKLKAHL---EKLEVDLNK 1145 Query: 529 EVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLK 570 ++ T E L ELK+ L + ++ +L ++LK Sbjct: 1146 SLKENTFLQEQL---VELKM-----LAEEDKRKVSELTSKLK 1179 Score = 69.3 bits (168), Expect = 2e-11 Identities = 125/623 (20%), Positives = 251/623 (40%), Gaps = 93/623 (14%) Query: 15 KDTGLNLFGMGGLQETSTTRTMKSRQAVSRVSREELE---DRFLR----LHDENILLKQH 67 +DT LN Q+++ ++ + + E+LE ++ L+ L ++ + LK Sbjct: 1104 QDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKML 1163 Query: 68 ARKQEDKIKRMATKLIRLVND----KKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELE 123 A + + K+ + +KL + K +E+ + + +E +++ E+L ++ Sbjct: 1164 AEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLE--DKSLEFKKLSEELAIQLDICC 1221 Query: 124 KQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRR---KANENAGLQECPRKGIKF 180 K+ E L + AK + + N + SRI+ + K E ++ C ++ Sbjct: 1222 KKTEAL----LEAKTN-ELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEA 1276 Query: 181 QDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKE 240 Q + E + + N ++A ++ EN I+S + IE L + + + +KE Sbjct: 1277 QLRQLTEEQNTL-----NISFQQATHQLEEKENQIKSMKADIESL-----VTEKEALQKE 1326 Query: 241 NEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQ-LVEKSNALSAMEGKF---------- 289 + +E T + + +N+ + L K+ L EK +S++ + Sbjct: 1327 GGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNS 1386 Query: 290 IQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSM---------KFSERR 340 I L EK+ + EL Q+++ K +L K+ S KFSE + Sbjct: 1387 ISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWK 1446 Query: 341 -------------IEELQDRINDLEKER-------ELLKENYD---KLYDSAFSAAHEEQ 377 ++ELQ ++ KE LLKE D K +D +++ Sbjct: 1447 KKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDK 1506 Query: 378 WKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTE----RDQNEKLVQENRELQLQYLE 433 K+++++ + LET LKS E+ D + + NE L N++ +++ E Sbjct: 1507 SKMEKKE-----SNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKE 1561 Query: 434 QKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLER 493 Q+L ++ +E D E E +L ++ Q +L K +N ++ Sbjct: 1562 LVQKLQHFQE----LGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKS 1617 Query: 494 SMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVH 553 EL+A E E E + ++ K + + + +ME ++ Y+ E ++ Sbjct: 1618 KEEELKA--LEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLS 1675 Query: 554 LLDI----RAARIHKLEAQLKDI 572 L+ R +H LE +LK + Sbjct: 1676 ELNTKLQEREREVHILEEKLKSV 1698 Score = 67.8 bits (164), Expect = 6e-11 Identities = 122/590 (20%), Positives = 245/590 (41%), Gaps = 86/590 (14%) Query: 56 RLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQL 115 ++H+ + ++ + +IK+M T+ L K++ ER + L + + + E+ Sbjct: 372 QMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAF--EELEKALSTAQKTEEA 429 Query: 116 QEKVH-ELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANEN--AGLQE 172 + K+ E+++Q +T++ + LQ + + V+ + +K++E A LQ+ Sbjct: 430 RRKLKAEMDEQIKTIEKTSEEERISLQQE------LSRVKQEVVDVMKKSSEEQIAKLQK 483 Query: 173 CPRKGIKFQDADVA---ETPHPMFTKYGNSLLEEARGEIRNLEN---------------- 213 K + ++ ++ +T F + LE+++ E + Sbjct: 484 LHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQ 543 Query: 214 ---VIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQA-------TDQRSNIR 263 ++ ++ +L+ AE +T++ E+ +E SL + + Q ++ + + Sbjct: 544 KKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNK 603 Query: 264 DNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLK 323 + M++ HK +E S + EK + L+ + M E Q KE LK Sbjct: 604 EITVMVEKHKTELE-----SLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLK 658 Query: 324 CCSLEKQLHSMKFSERRIEELQDRINDLE----------KERELLKENYDKLYDSAFSAA 373 + Q H + +E+ +E+L + +LE K R L+E L D Sbjct: 659 DKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMK 718 Query: 374 HEEQWKLKEQ-------------QLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKL 420 E + K+ EQ + +V I + E ALK D+ L+ L ERD++ K Sbjct: 719 QELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALK----DQINQLELLLKERDKHLKE 774 Query: 421 VQENRE-LQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLS- 478 Q + E L+ + +L + ++ ++ Q E ++A AQ +QK DL Sbjct: 775 HQAHVENLEADIKRSEGELQQASAKLDVF-QSYQSATHEQTKAYEEQLAQLQQKLLDLET 833 Query: 479 ---FLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTR 535 L K +E+ + EL A H VQ+L + K N + + +V+++T+ Sbjct: 834 ERILLTKQVAEVEAQKKDVCTELDA-HKIQVQDL------MQQLEKQNSEMEQKVKSLTQ 886 Query: 536 KMENLQQDYELKVEQYVHLLDIRAARIHKL-EAQLKDIAYGTKQYKFKPE 584 E+ +D + EQ +L + I ++ E Q K+I T++ K + Sbjct: 887 VYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKED 936 Score = 64.7 bits (156), Expect = 5e-10 Identities = 124/618 (20%), Positives = 248/618 (40%), Gaps = 130/618 (21%) Query: 107 EMEEMIEQLQEKVHELEKQNE---TLKNRLI-----------------------SAKQQL 140 E E + EQL E++ ELEK + K +LI + +Q Sbjct: 315 EKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMH 374 Query: 141 QTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIK--FQDADVAETPHPMFTKYGN 198 +T ++ ++SRI ++ + L+E K + F++ + A + + Sbjct: 375 ETLEMKEEEIAQLRSRI---KQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARR 431 Query: 199 SLLEEARGEIRNLENVIQSQRGQI--------------------EELEHLAEILKTQLRR 238 L E +I+ +E + +R + E++ L ++ + +L R Sbjct: 432 KLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELAR 491 Query: 239 KENEIELSLLQLREQQATDQR--------------SNIRDNVEMIKLHKQLVEKSNALSA 284 KE E+ LQ RE++ +Q S ++ E + L + ++K L+ Sbjct: 492 KEQEL-TKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTE 550 Query: 285 MEGKFIQLQEKQRTLRI-------------------SHDALMANGDELNMQLKEQRLKCC 325 E K LQ++ T R S D + E N KE + Sbjct: 551 SENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVE 610 Query: 326 SLEKQLHSMKFSERRI---------EELQDRINDLEKERELLKENYDKLYDSAFSAAHEE 376 + +L S+K + + ++ Q + L ++ E KE K + F A EE Sbjct: 611 KHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEE 670 Query: 377 QWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTE----RDQNEKLVQE-NRELQLQY 431 + ++L V+ +LE +L S+L++ + +L+ E +DQ +K+ QE ++ Q Sbjct: 671 MNEKTLEKLDVKQTELE-SLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQK 729 Query: 432 LEQKQQLDELKKRIKLYNQEND-INADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKD 490 +QQ+D + K ++ Q + D++++ LL+K + + + + +++ D Sbjct: 730 NHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEA----D 785 Query: 491 LERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQ 550 ++RS ELQ A +L+ ++ H+ K Y+ ++ + +K+ +L+ + L +Q Sbjct: 786 IKRSEGELQQASA----KLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQ 841 Query: 551 YVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENLFEIH 610 + ++EAQ KD+ +K + + D LE+ + E Sbjct: 842 -----------VAEVEAQKKDVCTELDAHKIQVQ----------DLMQQLEKQNSEMEQK 880 Query: 611 INKVTFSSEVLQASGDKE 628 + +T E G+KE Sbjct: 881 VKSLTQVYESKLEDGNKE 898 Score = 60.8 bits (146), Expect = 8e-09 Identities = 98/488 (20%), Positives = 209/488 (42%), Gaps = 63/488 (12%) Query: 112 IEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQ 171 +E LQ++V K+ E L R K+ +Q+ + Q + T ++A + L Sbjct: 281 LETLQQRV----KRQENLLKR---CKETIQS--------HKEQCTLLTSEKEALQEQ-LD 324 Query: 172 ECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLEN----VIQSQRGQIEELEH 227 E ++ K +D +AE + + L +A+ I LE VI + Q+ E Sbjct: 325 ERLQELEKIKDLHMAEKTKLI------TQLRDAKNLIEQLEQDKGMVIAETKRQMHETLE 378 Query: 228 LAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEG 287 + E QLR + ++ +LREQ+ +R+ + + + ++ E L A Sbjct: 379 MKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMD 438 Query: 288 KFIQLQEK---QRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEEL 344 + I+ EK + + + + + +++ K + L+K LH + + R+ +EL Sbjct: 439 EQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQK-LHEKELA-RKEQEL 496 Query: 345 QDRINDLEKE-RELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDK 403 ++ E+E +E +K +K + E KEQQ + + +LE K+ LT+ Sbjct: 497 TKKLQTREREFQEQMKVALEKSQSEYLKISQE-----KEQQESLALEELELQKKAILTES 551 Query: 404 TEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEAL 463 L R+LQ + + ++ EL+ ++ QEN + +L+ Sbjct: 552 ENKL-----------------RDLQQEAETYRTRILELESSLEKSLQENKNQSKDLA--- 591 Query: 464 LLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKIN 523 + ++A+K + N +++ +V+ + +LE + A E +Q L+ + K+ Sbjct: 592 VHLEAEKNKHNKEITVMVE---KHKTELESLKHQQDALWTEKLQVLK--QQYQTEMEKLR 646 Query: 524 KDYQMEVEAVTRKMENL-QQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFK 582 + + E E + + E + Q E E+ + LD++ + L ++L ++ + + + Sbjct: 647 EKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEE 706 Query: 583 PEIMPDDS 590 ++ D + Sbjct: 707 LSVLKDQT 714 Score = 51.2 bits (121), Expect = 6e-06 Identities = 80/408 (19%), Positives = 170/408 (41%), Gaps = 47/408 (11%) Query: 29 ETSTTRTMKSRQAVSRVSREELEDRF-LRLHDENILLK-QHARKQEDKIKRMATKLIRLV 86 + + T K Q V + E + F +R + L+K +HA ++ + + M L + Sbjct: 1742 QRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEEL 1801 Query: 87 NDK-KRYERV-------GGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQ 138 +K K+Y + GG + +E + + +Q+ + E E + L+ ++ + Sbjct: 1802 EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKI----K 1857 Query: 139 QLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGN 198 +L + RQ + V+ T + + + + K + + + E + Sbjct: 1858 ELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQ--P 1915 Query: 199 SLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLR--RKENEIELSLLQLREQQAT 256 LL + +LE + + ++L L+ LR RKE++ EL +L+ Q Sbjct: 1916 KLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQER 1975 Query: 257 DQRSNIRDNVEMIKLH-----KQLVEKSNALSAMEGKFIQLQEKQ---RTLRISHDALMA 308 +++ I+ E ++L KQL+ + N A + + +++ K+ + + + L + Sbjct: 1976 EEK--IKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLES 2033 Query: 309 NGDELNMQLKEQRLKCCSLEKQLHSMK-FSERRIEELQDRINDLEKERELLKENYDKLYD 367 + +E N LK+ K L++ + + R EE+ ++ DL+ + E L++ Y + + Sbjct: 2034 HQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLE 2093 Query: 368 SAFSAAHEE------------------QWKLKEQQLKVQIAQLETALK 397 + ++ KLKEQ+ + QI LE LK Sbjct: 2094 QEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLK 2141 Score = 47.0 bits (110), Expect = 1e-04 Identities = 118/559 (21%), Positives = 220/559 (39%), Gaps = 108/559 (19%) Query: 48 EELEDRFLRLHDENIL-LKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDV 106 EEL+ RL E+ L + RK E KI + +L+ + +K+ + G + Sbjct: 1620 EELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNT 1679 Query: 107 EMEEM---IEQLQEKVHELEK-QNETL------KN-RLISAKQQLQTQGYRQTPYN---N 152 +++E + L+EK+ +E Q+ETL KN + +++ +QG Q Y + Sbjct: 1680 KLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKIS 1739 Query: 153 VQSRINTGRRKANENAGLQ-------------ECPRKGIKFQDADVAETPHPMFTKYGNS 199 V R T + K + G + + + IK + A+ + + Sbjct: 1740 VLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQE 1799 Query: 200 LLEEARGEI--------------------RNLENVIQSQRGQIEELEHLAEILKTQLRRK 239 LEE + +NLENV + ++E E +IL+ +++ Sbjct: 1800 ELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKEL 1859 Query: 240 EN-----------EIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNA-----LS 283 ++ E+E + + QA Q E+++ + + KS+ LS Sbjct: 1860 DSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLS 1919 Query: 284 AMEGK---------------------FIQLQEKQRTLRISHDALMANGDELNMQLKEQRL 322 ME + ++LQ+ R LR H + + Q +E+++ Sbjct: 1920 NMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKI 1979 Query: 323 KCCSLEKQLHSMKFSERRIEELQDRINDLEKEREL-LKENYDKLYD--SAFSAAHEEQWK 379 K + +L ++ + E ++ E+E E+ +KE +K + + +H+E+ Sbjct: 1980 KQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEE-- 2037 Query: 380 LKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLD 439 QL +IA+ + LK EILD + E++ + R+LQ QL+ Sbjct: 2038 --TNQLLKKIAEKDDDLKRTAKRYEEILDA------REEEMTAKVRDLQ-------TQLE 2082 Query: 440 ELKKRI--KLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRE 497 EL+K+ KL +EN N + L AQK D + E +LE +++ Sbjct: 2083 ELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKK 2142 Query: 498 LQA-THAETVQELEKTRNM 515 + +A TV K N+ Sbjct: 2143 YEKNVYATTVGTPYKGGNL 2161 Score = 38.1 bits (87), Expect = 0.052 Identities = 64/307 (20%), Positives = 136/307 (44%), Gaps = 27/307 (8%) Query: 306 LMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKL 365 L+ N D LN + QRL+ +E+ L S + + EL L++E++ L+ + Sbjct: 127 LVGNSDSLNKEQLIQRLR--RMERSLSSYR---GKYSELVTAYQMLQREKKKLQGILSQS 181 Query: 366 YDSAFSAAHEEQWKLK-EQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQEN 424 D + E + +L+ +QQ K L+ + L +K + + L+T+ ++ ++ N Sbjct: 182 QDKSLRRIAELREELQMDQQAK---KHLQEEFDASLEEKDQYISVLQTQVSLLKQRLR-N 237 Query: 425 RELQLQYLEQKQQLD-ELKKRIKLYNQEND---INADELSEALLLIKAQKEQKNGDLSFL 480 + + L+ QL+ + + K N E+D + D S L Q+ ++ +L Sbjct: 238 GPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKR 297 Query: 481 VKVDSEINKD----LERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQM-EVEAVTR 535 K + +K+ L LQ E +QELEK +++ H K + ++ Sbjct: 298 CKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDL----HMAEKTKLITQLRDAKN 353 Query: 536 KMENLQQDYELKV----EQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSV 591 +E L+QD + + Q L+++ I +L +++K + ++ + + E + Sbjct: 354 LIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAF 413 Query: 592 DEFDETI 598 +E ++ + Sbjct: 414 EELEKAL 420 Score = 37.7 bits (86), Expect = 0.068 Identities = 58/297 (19%), Positives = 124/297 (41%), Gaps = 37/297 (12%) Query: 342 EELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLT 401 E+L R+ +E+ + Y +L +A+ E+ KL+ L + L Sbjct: 137 EQLIQRLRRMERSLSSYRGKYSELV-TAYQMLQREKKKLQ--------GILSQSQDKSLR 187 Query: 402 DKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQE---NDINADE 458 E+ + L+ ++ Q +K +QE + L+ E+ Q + L+ ++ L Q +N D Sbjct: 188 RIAELREELQMDQ-QAKKHLQEEFDASLE--EKDQYISVLQTQVSLLKQRLRNGPMNVDV 244 Query: 459 LS-------EALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEK 511 L +A + K + + +G+ V D K LE Q +++ Sbjct: 245 LKPLPQLEPQAEVFTKEENPESDGEP---VVEDGTSVKTLETLQ-----------QRVKR 290 Query: 512 TRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKD 571 N+L + + ++ + +T + E LQ+ + ++++ + D+ A KL QL+D Sbjct: 291 QENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRD 350 Query: 572 IAYGTKQYKFKPEIMPDDSVDEFDETIHLERGE-NLFEIHINKVTFSSEVLQASGDK 627 +Q + ++ ++ + ET+ ++ E I ++T E L+ +K Sbjct: 351 AKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEK 407 Database: hs.faa Posted date: Aug 4, 2009 4:42 PM Number of letters in database: 18,247,518 Number of sequences in database: 37,866 Lambda K H 0.314 0.132 0.365 Gapped Lambda K H 0.267 0.0410 0.140 Matrix: BLOSUM62 Gap Penalties: Existence: 11, Extension: 1 Number of Hits to DB: 44,433,610 Number of Sequences: 37866 Number of extensions: 2066997 Number of successful extensions: 15542 Number of sequences better than 10.0: 30 Number of HSP's better than 10.0 without gapping: 170 Number of HSP's successfully gapped in prelim test: 1046 Number of HSP's that attempted gapping in prelim test: 8561 Number of HSP's gapped (non-prelim): 4467 length of query: 1235 length of database: 18,247,518 effective HSP length: 114 effective length of query: 1121 effective length of database: 13,930,794 effective search space: 15616420074 effective search space used: 15616420074 T: 11 A: 40 X1: 16 ( 7.3 bits) X2: 38 (14.6 bits) X3: 64 (24.7 bits) S1: 42 (22.0 bits) S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.