Search of human proteins with 189217904

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|189217904 RPGRIP1-like isoform b [Homo sapiens]
         (1235 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|189217904 RPGRIP1-like isoform b [Homo sapiens]                   2441   0.0  
gi|118442834 RPGRIP1-like isoform a [Homo sapiens]                   2402   0.0  
gi|112734867 retinitis pigmentosa GTPase regulator interacting p...   629   e-180
gi|58530840 desmoplakin isoform I [Homo sapiens]                       93   2e-18
gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]             92   2e-18
gi|55770834 centromere protein F [Homo sapiens]                        91   7e-18
gi|148762940 DVL-binding protein DAPLE [Homo sapiens]                  87   8e-17
gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo sa...    86   2e-16
gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo s...    86   2e-16
gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin ...    86   2e-16
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi...    85   4e-16
gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo sap...    84   1e-15
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...    83   2e-15
gi|34577114 cytomatrix protein p110 [Homo sapiens]                     82   3e-15
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    81   7e-15
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    81   7e-15
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    81   7e-15
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    81   7e-15
gi|31982906 cingulin-like 1 [Homo sapiens]                             80   9e-15
gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]    80   1e-14
gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]     80   2e-14
gi|156104874 envoplakin [Homo sapiens]                                 80   2e-14
gi|21735548 centrosomal protein 2 [Homo sapiens]                       79   3e-14
gi|4885583 Rho-associated, coiled-coil containing protein kinase...    79   3e-14
gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]         79   3e-14
gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]           78   5e-14
gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]           78   5e-14
gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]           78   5e-14
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    78   5e-14
gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]     78   5e-14

>gi|189217904 RPGRIP1-like isoform b [Homo sapiens]
          Length = 1235

 Score = 2441 bits (6327), Expect = 0.0
 Identities = 1235/1235 (100%), Positives = 1235/1235 (100%)

Query: 1    MSGPTDETAGDLPVKDTGLNLFGMGGLQETSTTRTMKSRQAVSRVSREELEDRFLRLHDE 60
            MSGPTDETAGDLPVKDTGLNLFGMGGLQETSTTRTMKSRQAVSRVSREELEDRFLRLHDE
Sbjct: 1    MSGPTDETAGDLPVKDTGLNLFGMGGLQETSTTRTMKSRQAVSRVSREELEDRFLRLHDE 60

Query: 61   NILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVH 120
            NILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVH
Sbjct: 61   NILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVH 120

Query: 121  ELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKF 180
            ELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKF
Sbjct: 121  ELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKF 180

Query: 181  QDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKE 240
            QDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKE
Sbjct: 181  QDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKE 240

Query: 241  NEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLR 300
            NEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLR
Sbjct: 241  NEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLR 300

Query: 301  ISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKE 360
            ISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKE
Sbjct: 301  ISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKE 360

Query: 361  NYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKL 420
            NYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKL
Sbjct: 361  NYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKL 420

Query: 421  VQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFL 480
            VQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFL
Sbjct: 421  VQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFL 480

Query: 481  VKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENL 540
            VKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENL
Sbjct: 481  VKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENL 540

Query: 541  QQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHL 600
            QQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHL
Sbjct: 541  QQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHL 600

Query: 601  ERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQ 660
            ERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQ
Sbjct: 601  ERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQ 660

Query: 661  YLVHVNDLFLQYIQKNTITLEVHQAYSTEYETIAACQLKFHEILEKSGRIFCTASLIGTK 720
            YLVHVNDLFLQYIQKNTITLEVHQAYSTEYETIAACQLKFHEILEKSGRIFCTASLIGTK
Sbjct: 661  YLVHVNDLFLQYIQKNTITLEVHQAYSTEYETIAACQLKFHEILEKSGRIFCTASLIGTK 720

Query: 721  GDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKGPEHMQSLSQQAPKTAQLS 780
            GDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKGPEHMQSLSQQAPKTAQLS
Sbjct: 721  GDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKGPEHMQSLSQQAPKTAQLS 780

Query: 781  STDSTDGNLNELHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDD 840
            STDSTDGNLNELHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDD
Sbjct: 781  STDSTDGNLNELHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDD 840

Query: 841  HMYFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYIGKVNVPLISLAHDRCISGIFELT 900
            HMYFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYIGKVNVPLISLAHDRCISGIFELT
Sbjct: 841  HMYFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYIGKVNVPLISLAHDRCISGIFELT 900

Query: 901  DHQKHPAGTIHVILKWKFAYLPPSGSITTEDLGNFIRSEEPEVVQRLPPASSVSTLVLAP 960
            DHQKHPAGTIHVILKWKFAYLPPSGSITTEDLGNFIRSEEPEVVQRLPPASSVSTLVLAP
Sbjct: 901  DHQKHPAGTIHVILKWKFAYLPPSGSITTEDLGNFIRSEEPEVVQRLPPASSVSTLVLAP 960

Query: 961  RPKPRQRLTPVDKKVSFVDIMPHQSDVSQEGSVDEVKENTEKMQQGKDDVSLLSEGQLAE 1020
            RPKPRQRLTPVDKKVSFVDIMPHQSDVSQEGSVDEVKENTEKMQQGKDDVSLLSEGQLAE
Sbjct: 961  RPKPRQRLTPVDKKVSFVDIMPHQSDVSQEGSVDEVKENTEKMQQGKDDVSLLSEGQLAE 1020

Query: 1021 QSLASSEDETEITEDLEPEVEEDMSASDSDDCIIPGPISKNIKQPSEKIRIEIIALSLND 1080
            QSLASSEDETEITEDLEPEVEEDMSASDSDDCIIPGPISKNIKQPSEKIRIEIIALSLND
Sbjct: 1021 QSLASSEDETEITEDLEPEVEEDMSASDSDDCIIPGPISKNIKQPSEKIRIEIIALSLND 1080

Query: 1081 SQVTMDDTIQRLFVECRFYSLPAEETPVSLPKPKSGQWVYYNYSNVIYVDKENNKAKRDI 1140
            SQVTMDDTIQRLFVECRFYSLPAEETPVSLPKPKSGQWVYYNYSNVIYVDKENNKAKRDI
Sbjct: 1081 SQVTMDDTIQRLFVECRFYSLPAEETPVSLPKPKSGQWVYYNYSNVIYVDKENNKAKRDI 1140

Query: 1141 LKAILQKQEMPNRSLRFTVVSDPPEDEQDLECEDIGVAHVDLADMFQEGRDLIEQNIDVF 1200
            LKAILQKQEMPNRSLRFTVVSDPPEDEQDLECEDIGVAHVDLADMFQEGRDLIEQNIDVF
Sbjct: 1141 LKAILQKQEMPNRSLRFTVVSDPPEDEQDLECEDIGVAHVDLADMFQEGRDLIEQNIDVF 1200

Query: 1201 DARADGEGIGKLRVTVEALHALQSVYKQYRDDLEA 1235
            DARADGEGIGKLRVTVEALHALQSVYKQYRDDLEA
Sbjct: 1201 DARADGEGIGKLRVTVEALHALQSVYKQYRDDLEA 1235


>gi|118442834 RPGRIP1-like isoform a [Homo sapiens]
          Length = 1315

 Score = 2402 bits (6225), Expect = 0.0
 Identities = 1235/1315 (93%), Positives = 1235/1315 (93%), Gaps = 80/1315 (6%)

Query: 1    MSGPTDETAGDLPVKDTGLNLFGMGGLQETSTTRTMKSRQAVSRVSREELEDRFLRLHDE 60
            MSGPTDETAGDLPVKDTGLNLFGMGGLQETSTTRTMKSRQAVSRVSREELEDRFLRLHDE
Sbjct: 1    MSGPTDETAGDLPVKDTGLNLFGMGGLQETSTTRTMKSRQAVSRVSREELEDRFLRLHDE 60

Query: 61   NILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVH 120
            NILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVH
Sbjct: 61   NILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVH 120

Query: 121  ELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKF 180
            ELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKF
Sbjct: 121  ELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKF 180

Query: 181  QDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKE 240
            QDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKE
Sbjct: 181  QDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKE 240

Query: 241  NEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLR 300
            NEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLR
Sbjct: 241  NEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLR 300

Query: 301  ISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKE 360
            ISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKE
Sbjct: 301  ISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKE 360

Query: 361  NYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKL 420
            NYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKL
Sbjct: 361  NYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKL 420

Query: 421  VQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFL 480
            VQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFL
Sbjct: 421  VQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFL 480

Query: 481  VKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENL 540
            VKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENL
Sbjct: 481  VKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENL 540

Query: 541  QQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHL 600
            QQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHL
Sbjct: 541  QQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHL 600

Query: 601  ERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQ 660
            ERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQ
Sbjct: 601  ERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQ 660

Query: 661  YLVHVNDLFLQYIQKNTITLEVHQAYSTEYETIAACQLKFHEILEKSGRIFCTASLIGTK 720
            YLVHVNDLFLQYIQKNTITLEVHQAYSTEYETIAACQLKFHEILEKSGRIFCTASLIGTK
Sbjct: 661  YLVHVNDLFLQYIQKNTITLEVHQAYSTEYETIAACQLKFHEILEKSGRIFCTASLIGTK 720

Query: 721  GDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKGPEHMQSLSQQAPKTAQLS 780
            GDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKGPEHMQSLSQQAPKTAQLS
Sbjct: 721  GDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKGPEHMQSLSQQAPKTAQLS 780

Query: 781  STDSTDGNLNELHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDD 840
            STDSTDGNLNELHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDD
Sbjct: 781  STDSTDGNLNELHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDD 840

Query: 841  HMYFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYIGKVNVPLISLAHDRCISGIFELT 900
            HMYFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYIGKVNVPLISLAHDRCISGIFELT
Sbjct: 841  HMYFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYIGKVNVPLISLAHDRCISGIFELT 900

Query: 901  DHQKHPAGTIHVILKWKFAYLPPSGSITTEDLGNFIRSEEPEVVQRLPPASSVSTLVLAP 960
            DHQKHPAGTIHVILKWKFAYLPPSGSITTEDLGNFIRSEEPEVVQRLPPASSVSTLVLAP
Sbjct: 901  DHQKHPAGTIHVILKWKFAYLPPSGSITTEDLGNFIRSEEPEVVQRLPPASSVSTLVLAP 960

Query: 961  RPKPRQRLTPVDKKVSFVDIMPHQSD---------------------------------- 986
            RPKPRQRLTPVDKKVSFVDIMPHQSD                                  
Sbjct: 961  RPKPRQRLTPVDKKVSFVDIMPHQSDETSPPPEDRKEISPEVEHIPEIEINMLTVPHVPK 1020

Query: 987  VSQEGSVDEVKENTEKMQQGKDDVSLLSEGQLAEQSLASSEDETEITEDLEPEVEEDMSA 1046
            VSQEGSVDEVKENTEKMQQGKDDVSLLSEGQLAEQSLASSEDETEITEDLEPEVEEDMSA
Sbjct: 1021 VSQEGSVDEVKENTEKMQQGKDDVSLLSEGQLAEQSLASSEDETEITEDLEPEVEEDMSA 1080

Query: 1047 SDSDDCIIPGPISKNIKQ------------------------------------------ 1064
            SDSDDCIIPGPISKNIKQ                                          
Sbjct: 1081 SDSDDCIIPGPISKNIKQSLALSPGLGCSSAISAHCNFRLPGSSDFPASASQVDGITGAC 1140

Query: 1065 ----PSEKIRIEIIALSLNDSQVTMDDTIQRLFVECRFYSLPAEETPVSLPKPKSGQWVY 1120
                PSEKIRIEIIALSLNDSQVTMDDTIQRLFVECRFYSLPAEETPVSLPKPKSGQWVY
Sbjct: 1141 HHTQPSEKIRIEIIALSLNDSQVTMDDTIQRLFVECRFYSLPAEETPVSLPKPKSGQWVY 1200

Query: 1121 YNYSNVIYVDKENNKAKRDILKAILQKQEMPNRSLRFTVVSDPPEDEQDLECEDIGVAHV 1180
            YNYSNVIYVDKENNKAKRDILKAILQKQEMPNRSLRFTVVSDPPEDEQDLECEDIGVAHV
Sbjct: 1201 YNYSNVIYVDKENNKAKRDILKAILQKQEMPNRSLRFTVVSDPPEDEQDLECEDIGVAHV 1260

Query: 1181 DLADMFQEGRDLIEQNIDVFDARADGEGIGKLRVTVEALHALQSVYKQYRDDLEA 1235
            DLADMFQEGRDLIEQNIDVFDARADGEGIGKLRVTVEALHALQSVYKQYRDDLEA
Sbjct: 1261 DLADMFQEGRDLIEQNIDVFDARADGEGIGKLRVTVEALHALQSVYKQYRDDLEA 1315


>gi|112734867 retinitis pigmentosa GTPase regulator interacting
            protein 1 [Homo sapiens]
          Length = 1286

 Score =  629 bits (1622), Expect = e-180
 Identities = 435/1336 (32%), Positives = 697/1336 (52%), Gaps = 155/1336 (11%)

Query: 1    MSGPTDETAGDLPVKDTGLNLFGMGGLQETSTTRTMKSRQAVSRVSREELEDRFLRLHDE 60
            MS   D T+GDLPV+D    +  +  +   S  + MK++  +SR++REELED F RL ++
Sbjct: 1    MSHLVDPTSGDLPVRD----IDAIPLVLPASKGKNMKTQPPLSRMNREELEDSFFRLRED 56

Query: 61   NILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVH 120
            ++L+K+ + KQ+D+IKR+ T L+RL                 GRD+ + E    L E   
Sbjct: 57   HMLVKELSWKQQDEIKRLRTTLLRLT--------------AAGRDLRVAEEAAPLSETAR 102

Query: 121  ELEKQNETLKNRLISAKQQLQTQGY----RQTPYNNVQSRINTGRRKAN-ENAGLQECPR 175
              +K     +  +    Q  + QG+            Q R+  G R+ +   A + E P+
Sbjct: 103  RGQKAGWRQRLSMHQRPQMHRLQGHFHCVGPASPRRAQPRVQVGHRQLHTAGAPVPEKPK 162

Query: 176  KGIKFQDADVAETPHPMFTKYGNSLLEEARGEIR-------------------------- 209
            +G + +   ++ T  P F ++  +   E RGE+                           
Sbjct: 163  RGPRDR---LSYTAPPSFKEHATN---ENRGEVASKPSELVSGSNSIISFSSVISMAKPI 216

Query: 210  -----NLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRD 264
                 N  +++ S   Q+EE     E       + EN  + S L+   Q+A + R++I++
Sbjct: 217  GLCMPNSAHIMASNTMQVEEPPKSPE---KMWPKDENFEQRSSLEC-AQKAAELRASIKE 272

Query: 265  NVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRT--------LRISHDALMANGDELNMQ 316
             VE+I+L K L E++ +L   + +  ++QE   T        L  +H+AL+   +EL  +
Sbjct: 273  KVELIRLKKLLHERNASLVMTKAQLTEVQEAYETLLQKNQGILSAAHEALLKQVNELRAE 332

Query: 317  LKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDS---AFSAA 373
            LKE+  K  SL+ QL  +   +  ++E Q+R+ DLEKER+LL +NYDKL +S   +  ++
Sbjct: 333  LKEESKKAVSLKSQLEDVSILQMTLKEFQERVEDLEKERKLLNDNYDKLLESMLDSSDSS 392

Query: 374  HEEQW--KLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQY 431
             +  W  +L  +QL+ Q++QL+  L ++L DK ++L  L  E+ QNE L  E   +    
Sbjct: 393  SQPHWSNELIAEQLQQQVSQLQDQLDAELEDKRKVLLELSREKAQNEDLKLEVTNI---- 448

Query: 432  LEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDL 491
            L++ +Q  EL +     +Q  D  ++  +   +L      Q+N  +      + E  K L
Sbjct: 449  LQKHKQEVELLQNAATISQPPDRQSEPATHPAVL------QENTQIEPSEPKNQE-EKKL 501

Query: 492  ERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQY 551
             + + ELQ +HAET  ELEKTR+MLI+Q KIN  YQ E+EA+  K +N  +D++ K+E+ 
Sbjct: 502  SQVLNELQVSHAETTLELEKTRDMLILQRKINVCYQEELEAMMTKADNDNRDHKEKLERL 561

Query: 552  VHLLDIRAARIHKLEA-----------QLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHL 600
              LLD++  RI +LE            QLKD+AYGT+      E +P    ++  +   L
Sbjct: 562  TRLLDLKNNRIKQLEGILRSHDLPTSEQLKDVAYGTRPLSLCLETLPAHGDEDKVDISLL 621

Query: 601  ERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQ 660
             +GENLFE+HI++   +S  L  +GD +P TFCTY+FYDFE   TP+  G  P Y+FTSQ
Sbjct: 622  HQGENLFELHIHQAFLTSAALAQAGDTQPTTFCTYSFYDFETHCTPLSVGPQPLYDFTSQ 681

Query: 661  YLVHVNDLFLQYIQKNTITLEVHQAYSTEYETIAACQLKFHEILEKSGRIFCTASLIGTK 720
            Y++  + LFL Y+Q+ +  L++HQA ++E+ T+AA  + F  +LE   ++   A+LIG  
Sbjct: 682  YVMETDSLFLHYLQEASARLDIHQAMASEHSTLAAGWICFDRVLETVEKVHGLATLIGAG 741

Query: 721  GDIPNFGTVEYWFRLRVPMDQAIRLYRERAKALGYITSNFKGPEHMQSLSQQAPKTAQLS 780
            G+   FG +EYW RLR P+  +++   +R KA  Y++++  G    Q          +  
Sbjct: 742  GE--EFGVLEYWMRLRFPIKPSLQACNKRKKAQVYLSTDVLGGRKAQE---------EEF 790

Query: 781  STDSTDGNLNELHITIRCCNHLQSRASHLQPHPYVVYKFFDFADHDTAIIPSSNDPQFDD 840
             ++S +   NEL I I  C  L+SR    QP PY VY+FF F+DHDTAIIP+SN+P F D
Sbjct: 791  RSESWEPQ-NELWIEITKCCGLRSRWLGTQPSPYAVYRFFTFSDHDTAIIPASNNPYFRD 849

Query: 841  HMYFPVPMNMDLDRYLKSESLSFYVFDDSDTQENIYIGKVNVPLISLAHDRCISGIFELT 900
               FPV +  DLD YL+ E+LS +VFDD D +   Y+G+  VPL+ LA +  I G F LT
Sbjct: 850  QARFPVLVTSDLDHYLRREALSIHVFDDEDLEPGSYLGRARVPLLPLAKNESIKGDFNLT 909

Query: 901  DHQKHPAGTIHVILKWKFAYLPPSGSI---------TTEDLGNFIRSEE----PEVVQRL 947
            D  + P G+I V L WKF Y+PP   +          T+D       EE    P   Q  
Sbjct: 910  DPAEKPNGSIQVQLDWKFPYIPPESFLKPEAQTKGKDTKDSSKISSEEEKASFPSQDQMA 969

Query: 948  PPASSVSTLVLAPRPKPRQRLTPVDKKVSFVDI--MPHQSDVSQEG-------SVDEVKE 998
             P   +       + KP       +K+   V      H   +  +G       S++ +  
Sbjct: 970  SPEVPIEAGQYRSKRKPPHGGERKEKEHQVVSYSRRKHGKRIGVQGKNRMEYLSLNILNG 1029

Query: 999  NTEKM-----QQGKDDVSLLSEG---QLAEQSLASSEDETEITEDLEPEVEEDMS----- 1045
            NT +       +  +  S + +G   Q  E+ +  S    +  E L P  +++ S     
Sbjct: 1030 NTPEQVNYTEWKFSETNSFIGDGFKNQHEEEEMTLSHSALKQKEPLHPVNDKESSEQGSE 1089

Query: 1046 -----ASDSDDCIIPGPISKNIKQPSEKIRIEIIALSL-NDSQVTMDDTIQRLFVECRFY 1099
                  +DSDD I+P    K  K  SEK+ IEI++L+   +++V  D+ I++++VE +FY
Sbjct: 1090 VSEAQTTDSDDVIVPPMSQKYPKADSEKMCIEIVSLAFYPEAEVMSDENIKQVYVEYKFY 1149

Query: 1100 SLPAE--ETPVSLPKPKSGQWVYYNYSNVIYVDKENNKAKRDILKAILQKQEMPNRSLRF 1157
             LP    ETPVSL KP++G+ +++++S VI +D +  + +R  L  +L  Q+     L+F
Sbjct: 1150 DLPLSETETPVSLRKPRAGEEIHFHFSKVIDLDPQEQQGRRRFLFDMLNGQDPDQGHLKF 1209

Query: 1158 TVVSDPPEDEQDLECEDIGVAHVDLADMFQEGRDLIEQNIDVFDARADGEGIGKLRVTVE 1217
            TVVSD P DE+  ECE++G A++ L  + + GRD++EQ +D+         IG+L+V+++
Sbjct: 1210 TVVSD-PLDEEKKECEEVGYAYLQLWQILESGRDILEQELDIVSPEDLATPIGRLKVSLQ 1268

Query: 1218 ALHALQSVYKQYRDDL 1233
            A   L ++YK+  +DL
Sbjct: 1269 AAAVLHAIYKEMTEDL 1284


>gi|58530840 desmoplakin isoform I [Homo sapiens]
          Length = 2871

 Score = 92.8 bits (229), Expect = 2e-18
 Identities = 126/540 (23%), Positives = 243/540 (45%), Gaps = 76/540 (14%)

Query: 47   REELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDV 106
            R E   R+ +  D+     Q   K+ +++K++  K     ND+K  E      +R+  D+
Sbjct: 1458 RTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKE---TNDRKCLEDENARLQRVQYDL 1514

Query: 107  EME-----EMIEQLQEKVHELEK---------QNETLKNRLISAKQQLQTQGYRQTPYNN 152
            +       E I +L+ +  EL +         Q  T+K++ I+  Q    +   Q     
Sbjct: 1515 QKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLKE--LQLQKQK 1572

Query: 153  VQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGN--SLLEEARGEIRN 210
            V+  +N  +R A+E++    C RK ++ +   +  +      K  N    LE+A    + 
Sbjct: 1573 VEEELNRLKRTASEDS----CKRKKLEEELEGMRRSLKEQAIKITNLTQQLEQASIVKKR 1628

Query: 211  LENVIQSQRGQIEELEHLAEILKTQ--LRRKENEIELSLLQLREQQATDQRSNIR----- 263
             E+ ++ QR  ++   HL E  +TQ  LRR  +E+E    QL ++Q + +++++R     
Sbjct: 1629 SEDDLRQQRDVLDG--HLREKQRTQEELRRLSSEVEALRRQLLQEQESVKQAHLRNEHFQ 1686

Query: 264  ----DNVEMIKLHKQLVEKSNALSA-MEGKFIQLQEKQRTLRISHDALMANGDELNMQLK 318
                D    +   K  +E+  +L+  +  + + L+E+ R LR+ +D L     E +    
Sbjct: 1687 KAIEDKSRSLNESKIEIERLQSLTENLTKEHLMLEEELRNLRLEYDDLRRGRSEAD---S 1743

Query: 319  EQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQW 378
            ++      L  QL   + S  R  ELQ  INDL++ERE L++  +K    A  A++    
Sbjct: 1744 DKNATILELRSQL---QISNNRTLELQGLINDLQRERENLRQEIEKFQKQALEASN---- 1796

Query: 379  KLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQL 438
              + Q+ K Q  Q+    +S L  K ++L++ K    + E  +   +         KQ+L
Sbjct: 1797 --RIQESKNQCTQVVQERES-LLVKIKVLEQDKARLQRLEDELNRAKSTLEAETRVKQRL 1853

Query: 439  DELKKRIKLYNQENDINA-----DELSEALLLIKAQKE----QKNGDLSFLVKVDSEINK 489
            +  K++I     +ND+N          EA+  I++++E    +KN   S + ++ +EI +
Sbjct: 1854 ECEKQQI-----QNDLNQWKTQYSRKEEAIRKIESEREKSEREKNSLRSEIERLQAEIKR 1908

Query: 490  DLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVE 549
              ER  R+L+ +  ET  +LE  R+           YQ E++ + ++     ++ + + E
Sbjct: 1909 IEERCRRKLEDSTRETQSQLETERSR----------YQREIDKLRQRPYGSHRETQTECE 1958



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 107/536 (19%), Positives = 218/536 (40%), Gaps = 64/536 (11%)

Query: 65   KQHARKQEDKIKRMATKLIRL---VNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHE 121
            KQ+  K   +IK +  K+ RL   + D+KR  +         R  + +   +QLQ K  +
Sbjct: 1094 KQNLDKCYGQIKELNEKITRLTYEIEDEKRRRK-----SVEDRFDQQKNDYDQLQ-KARQ 1147

Query: 122  LEKQN----ETLKNRLISAKQQ--------LQTQGYRQTPYNNVQSRINTG--------R 161
             EK+N    +    + I  K+         LQ +G R+  Y N  +++           R
Sbjct: 1148 CEKENLGWQKLESEKAIKEKEYEIERLRVLLQEEGTRKREYENELAKVRNHYNEEMSNLR 1207

Query: 162  RKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQS--QR 219
             K      + +   K I  Q  D ++       +      +     +R  ++++Q+  QR
Sbjct: 1208 NKYETEINITKTTIKEISMQKEDDSKNLRNQLDRLSRENRDLKDEIVRLNDSILQATEQR 1267

Query: 220  GQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKS 279
             + EE     +   +++ +K+  +E+ L Q+ +Q++ D   N R    + +  K + +K+
Sbjct: 1268 RRAEENALQQKACGSEIMQKKQHLEIELKQVMQQRSED---NARHKQSLEEAAKTIQDKN 1324

Query: 280  NALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQ-LHSMKFS- 337
              +  ++ +F +  +++         +  N DE  + LK Q     ++ K  +H +    
Sbjct: 1325 KEIERLKAEFQEEAKRRWEYENELSKVRNNYDEEIISLKNQFETEINITKTTIHQLTMQK 1384

Query: 338  ERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHE--------EQWKLKEQQLKVQI 389
            E      + +I++L +E   L E   +L ++               +Q K    ++  + 
Sbjct: 1385 EEDTSGYRAQIDNLTRENRSLSEEIKRLKNTLTQTTENLRRVEEDIQQQKATGSEVSQRK 1444

Query: 390  AQLETALKSDLTDKTEILDRLKTERDQNEKLVQE-NRELQ-LQYLEQKQQLDE------- 440
             QLE  L+     +TE   R K   D   K +Q+ N+E++ L+ L  K+  D        
Sbjct: 1445 QQLEVELRQVTQMRTEESVRYKQSLDDAAKTIQDKNKEIERLKQLIDKETNDRKCLEDEN 1504

Query: 441  -LKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLER---SMR 496
               +R++   Q+ + +A E    L + + +  +   D   + +  +  ++D+ R   S++
Sbjct: 1505 ARLQRVQYDLQKANSSATETINKLKVQEQELTRLRIDYERVSQERTVKDQDITRFQNSLK 1564

Query: 497  ELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTR-------KMENLQQDYE 545
            ELQ    +  +EL + +          K  + E+E + R       K+ NL Q  E
Sbjct: 1565 ELQLQKQKVEEELNRLKRTASEDSCKRKKLEEELEGMRRSLKEQAIKITNLTQQLE 1620



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 104/494 (21%), Positives = 207/494 (41%), Gaps = 57/494 (11%)

Query: 152  NVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYG----NSLLEEARGE 207
            N+ S I+  R K+ E   + E     IK  +  +A     + T        ++++   G 
Sbjct: 932  NLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYTSGLETLLNIPIKRTMIQSPSGV 991

Query: 208  IRNLENVIQSQRGQIEELEH-------LAEILKTQLRRKENEIELSLLQLREQQATDQRS 260
            I  L+         IE L         L+E+LK+    K    ++ +L+   + A D  S
Sbjct: 992  I--LQEAADVHARYIELLTRSGDYYRFLSEMLKSLEDLKLKNTKIEVLEEELRLARDANS 1049

Query: 261  NIRDNVEMIKLHKQLVEKSNA-LSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKE 319
               +N    K   Q ++K  A  S  + K   L+E +R   +   +   N D+   Q+KE
Sbjct: 1050 ---ENCNKNKFLDQNLQKYQAECSQFKAKLASLEELKRQAELDGKSAKQNLDKCYGQIKE 1106

Query: 320  QRLKCCSL----EKQLHSMKFSERRIEELQDRINDLEKERELLKEN--YDKLYDSAFSAA 373
               K   L    E +    K  E R ++ ++  + L+K R+  KEN  + KL        
Sbjct: 1107 LNEKITRLTYEIEDEKRRRKSVEDRFDQQKNDYDQLQKARQCEKENLGWQKL-------- 1158

Query: 374  HEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLE 433
             E +  +KE++ +++  +L   L+ + T K E  + L   R+        N E+     +
Sbjct: 1159 -ESEKAIKEKEYEIE--RLRVLLQEEGTRKREYENELAKVRN------HYNEEMSNLRNK 1209

Query: 434  QKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDL-SFLVKVDSEINKDLE 492
             + +++  K  IK  + + + ++  L   L     +  ++N DL   +V+++  I +  E
Sbjct: 1210 YETEINITKTTIKEISMQKEDDSKNLRNQL----DRLSRENRDLKDEIVRLNDSILQATE 1265

Query: 493  RSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYV 552
            +  R      AE     +K     IMQ K  +  ++E++ V ++       ++  +E+  
Sbjct: 1266 QRRR------AEENALQQKACGSEIMQKK--QHLEIELKQVMQQRSEDNARHKQSLEEAA 1317

Query: 553  HLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENLFEIHIN 612
              +  +   I +L+A+ ++ A   ++++++ E+      + +DE I   + +   EI+I 
Sbjct: 1318 KTIQDKNKEIERLKAEFQEEA--KRRWEYENEL--SKVRNNYDEEIISLKNQFETEINIT 1373

Query: 613  KVTFSSEVLQASGD 626
            K T     +Q   D
Sbjct: 1374 KTTIHQLTMQKEED 1387



 Score = 33.1 bits (74), Expect = 1.7
 Identities = 49/244 (20%), Positives = 109/244 (44%), Gaps = 18/244 (7%)

Query: 323 KCCSLEKQLHSMKFSERRIEELQDR-INDLEKERELLK-----ENYDKLYDSAFSAAHEE 376
           K C L+ ++  +      I  + D  +N L   R LL+     E+  K+Y++  +   EE
Sbjct: 738 KYCYLQNEVFGLFQKLENINGVTDGYLNSLCTVRALLQAILQTEDMLKVYEARLT--EEE 795

Query: 377 QWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKL-VQENRELQLQYLEQK 435
              L   +++     L+  +K+DL  K  +L  +KTE  + +++  Q +++  L  L+  
Sbjct: 796 TVCLDLDKVEAYRCGLKK-IKNDLNLKKSLLATMKTELQKAQQIHSQTSQQYPLYDLDLG 854

Query: 436 ---QQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLE 492
              +++ +L  R +  +++ D    +L + +  ++  ++       +L   D++  +D  
Sbjct: 855 KFGEKVTQLTDRWQRIDKQIDFRLWDLEKQIKQLRNYRDNYQAFCKWLY--DAKRRQD-- 910

Query: 493 RSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYV 552
            S+  ++   + TV      +  L  +    +D   EV+ +     N  +DYEL++  Y 
Sbjct: 911 -SLESMKFGDSNTVMRFLNEQKNLHSEISGKRDKSEEVQKIAELCANSIKDYELQLASYT 969

Query: 553 HLLD 556
             L+
Sbjct: 970 SGLE 973


>gi|55770888 early endosome antigen 1, 162kD [Homo sapiens]
          Length = 1411

 Score = 92.4 bits (228), Expect = 2e-18
 Identities = 143/653 (21%), Positives = 279/653 (42%), Gaps = 81/653 (12%)

Query: 12  LPVKDTGLNLFGMGGLQETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQ 71
           L   +T L+   +   ++   T+ +K   +      + L+  F +L  +    +QH  + 
Sbjct: 353 LSASETSLHRIHVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQL 412

Query: 72  EDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKN 131
           + +I ++ +KL  L  +++  E  G           ++E  +   EK+ + E+Q   L+ 
Sbjct: 413 QSEINQLHSKL--LETERQLGEAHG----------RLKEQRQLSSEKLMDKEQQVADLQL 460

Query: 132 RLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHP 191
           +L   ++QL+    + T    +Q +++  +++  E   LQ+     ++    D+ +    
Sbjct: 461 KLSRLEEQLKE---KVTNSTELQHQLDKTKQQHQEQQALQQSTTAKLREAQNDLEQVLRQ 517

Query: 192 MFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLR 251
           +  K           +I+NLE ++Q  +  I  LE   E L  +++  E E  + L QL+
Sbjct: 518 IGDK---------DQKIQNLEALLQKSKENISLLEKEREDLYAKIQAGEGETAV-LNQLQ 567

Query: 252 EQQATDQRSNIRDNVEMIKLHKQLVEKSNA-LSAMEGKFIQLQEKQRTLRISHD---ALM 307
           E+  T Q        ++ +L ++L  +S +   A E    Q+QE++  LR + D   +L 
Sbjct: 568 EKNHTLQE-------QVTQLTEKLKNQSESHKQAQENLHDQVQEQKAHLRAAQDRVLSLE 620

Query: 308 ANGDELNMQLKEQRLKCCSLEKQLHS-----MKFSERRIEELQDRINDLEKERELLKENY 362
            + +ELN QL E + K   L+ Q+ +     +     +  +  D  N L+  +  L+   
Sbjct: 621 TSVNELNSQLNESKEKVSQLDIQIKAKTELLLSAEAAKTAQRADLQNHLDTAQNALQ--- 677

Query: 363 DKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKS------DLTDKTEILDRLKTERDQ 416
           DK  +        +Q   K Q  +   +QLE+ LK        L  KTE L+    + + 
Sbjct: 678 DKQQELNKITTQLDQVTAKLQDKQEHCSQLESHLKEYKEKYLSLEQKTEELEGQIKKLEA 737

Query: 417 NEKLVQENRELQLQYLEQKQQLD--------ELKKRIKLYNQ---ENDINADELSEALLL 465
           +   V+ ++E  LQ L+Q++QL+        EL K++++  +      ++  + SEAL  
Sbjct: 738 DSLEVKASKEQALQDLQQQRQLNTDLELRATELSKQLEMEKEIVSSTRLDLQKKSEALES 797

Query: 466 IKAQKEQKNGDLSFLVKVD------------SEINKDLERSMRELQATHAE---TVQELE 510
           IK QK  K  +   ++K D             E+N  ++ ++ ELQ    E    + EL 
Sbjct: 798 IK-QKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVKMEKEALMTELS 856

Query: 511 KTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLK 570
             ++ L       K+ + E E   +K +    D E   ++  H L ++     K + +LK
Sbjct: 857 TVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQVQMENTLKEQKELK 916

Query: 571 DIAYGTK----QYKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSE 619
                 K    Q K +   M +  +   +     E+ E   + +IN++  SSE
Sbjct: 917 KSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKEEQQLQGNINELKQSSE 969



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 108/520 (20%), Positives = 220/520 (42%), Gaps = 66/520 (12%)

Query: 48   EELEDRFLRLHDENILLKQ--HARKQEDKIKR--MATKLIRLVNDKKRYERVGGGPKRLG 103
            E ++ +  +  +E  +LKQ      QE KI+   +  ++   V + ++ +          
Sbjct: 796  ESIKQKLTKQEEEKQILKQDFETLSQETKIQHEELNNRIQTTVTELQKVK---------- 845

Query: 104  RDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRK 163
              +E E ++ +L     +L K +++LKN     +++ Q               +    + 
Sbjct: 846  --MEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTCKELKHQLQV 903

Query: 164  ANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEE---ARGEIRNLENVIQSQRG 220
              EN  L+E  +K +K       E  H +  +  NS+ E+   A+  ++  E   Q  +G
Sbjct: 904  QMENT-LKE--QKELKKSLEKEKEASHQLKLEL-NSMQEQLIQAQNTLKQNEKEEQQLQG 959

Query: 221  QIEELEHLAEILKTQLRRKENEIELSLLQLRE------QQATDQRSNIRDNVEMIKLHKQ 274
             I EL+  +E  K Q+   + E+++++LQ  E      QQ T     +    E I + + 
Sbjct: 960  NINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLTQAAQELAAEKEKISVLQN 1019

Query: 275  LVEKSN-ALSAMEGKFI-----------QLQEKQRTLRISHDALMANGDELNMQLKE-QR 321
              EKS      ++  F             L+  +  L ++ + L++N +++  Q K  Q 
Sbjct: 1020 NYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIGNQNKLIQE 1079

Query: 322  LKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLK 381
            LK      +  S K  E++++E    + D++KE+ L ++   +L +     A  E+ K +
Sbjct: 1080 LKTAKATLEQDSAK-KEQQLQERCKALQDIQKEKSLKEK---ELVNEKSKLAEIEEIKCR 1135

Query: 382  EQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDEL 441
            +++   +I +L   LKS    K E +  +   +D  + L+Q+  ELQ        + D L
Sbjct: 1136 QEK---EITKLNEELKSH---KLESIKEITNLKDAKQLLIQQKLELQ-------GKADSL 1182

Query: 442  KKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQAT 501
            K  ++   +   I  D++       K ++E K   +    K+ SEI K+ E  M++ +  
Sbjct: 1183 KAAVEQEKRNQQILKDQVK------KEEEELKKEFIEKEAKLHSEI-KEKEVGMKKHEEN 1235

Query: 502  HAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQ 541
             A+   ++      L    K  +  Q  V  + ++ ++L+
Sbjct: 1236 EAKLTMQITALNENLGTVKKEWQSSQRRVSELEKQTDDLR 1275



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 85/416 (20%), Positives = 186/416 (44%), Gaps = 52/416 (12%)

Query: 198 NSLLEEARGEIRNLENVI---QSQRGQIEELEHLAEILKTQLRRKENEI------ELSLL 248
           + L+ ++  E+++LE  +   Q++   I++++ L E    QL  +  +I      E SL 
Sbjct: 127 DGLVTDSSAELQSLEQQLEEAQTENFNIKQMKDLFEQKAAQLATEIADIKSKYDEERSLR 186

Query: 249 QLREQQATDQRSNIRDNVEMIK-LHKQLVEKSNA--LSAMEGKFIQLQEKQRTLRISHDA 305
           +  EQ+ T     +     +I+ L  +L+++     ++ ++ + +Q+Q     + +  + 
Sbjct: 187 EAAEQKVTRLTEELNKEATVIQDLKTELLQRPGIEDVAVLKKELVQVQTLMDNMTLERER 246

Query: 306 LMANGDELNMQLKEQRLKCCSLEKQLHSMKFS-----------ERRIEELQDRINDLEKE 354
                ++L  + K+ + +  S E  +  ++              + +++L+  +N+L ++
Sbjct: 247 ---ESEKLKDECKKLQSQYASSEATISQLRSELAKGPQEVAVYVQELQKLKSSVNELTQK 303

Query: 355 RELLKENYDKLYD--SAFSAAHEEQWKLKEQ------QLKVQIAQLETALKSDLTDKTEI 406
            + L EN  K     +     H E+   K+       Q  +   QL++ L +  T    I
Sbjct: 304 NQTLTENLLKKEQDYTKLEEKHNEESVSKKNIQATLHQKDLDCQQLQSRLSASETSLHRI 363

Query: 407 LDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQ-----ENDINADELSE 461
              L  + +  +KL +E  E++ +Y   K +  +L+++ +   Q     +++IN  +L  
Sbjct: 364 HVELSEKGEATQKLKEELSEVETKYQHLKAEFKQLQQQREEKEQHGLQLQSEIN--QLHS 421

Query: 462 ALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQEL-EKTRNMLIMQH 520
            LL  + Q  + +G L    ++ SE   D E+ + +LQ   +   ++L EK  N   +QH
Sbjct: 422 KLLETERQLGEAHGRLKEQRQLSSEKLMDKEQQVADLQLKLSRLEEQLKEKVTNSTELQH 481

Query: 521 KINKDYQMEVE------AVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLK 570
           +++K  Q   E      + T K+   Q D    +EQ +  +  +  +I  LEA L+
Sbjct: 482 QLDKTKQQHQEQQALQQSTTAKLREAQND----LEQVLRQIGDKDQKIQNLEALLQ 533



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 100/556 (17%), Positives = 232/556 (41%), Gaps = 52/556 (9%)

Query: 49   ELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEM 108
            +LE       ++ + L+Q   + E +IK++    + +   K++  +     ++L  D+E+
Sbjct: 706  QLESHLKEYKEKYLSLEQKTEELEGQIKKLEADSLEVKASKEQALQDLQQQRQLNTDLEL 765

Query: 109  E--EMIEQLQEKVH-------ELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINT 159
               E+ +QL+ +         +L+K++E L++      +Q + +   +  +  +      
Sbjct: 766  RATELSKQLEMEKEIVSSTRLDLQKKSEALESIKQKLTKQEEEKQILKQDFETLSQETKI 825

Query: 160  GRRKANENAGLQECPRKGIKFQ-DADVAE--TPHPMFTKYGNSLLEEARGEIRNLENVIQ 216
               + N          + +K + +A + E  T     +K  +SL    +      E   Q
Sbjct: 826  QHEELNNRIQTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSL----KNSKSEFEKENQ 881

Query: 217  SQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLV 276
              +  I +LE   + LK QL+ +         +L++    ++ ++ +  +E+  + +QL+
Sbjct: 882  KGKAAILDLEKTCKELKHQLQVQMENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLI 941

Query: 277  EKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQL-HSMK 335
            +  N L   E +  QLQ     L+ S +      + L  +LK   L+   LE +L   + 
Sbjct: 942  QAQNTLKQNEKEEQQLQGNINELKQSSEQKKKQIEALQGELKIAVLQKTELENKLQQQLT 1001

Query: 336  FSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETA 395
             + + +   +++I+ L+   E  +E + +L    +    E +     Q LK    +L  A
Sbjct: 1002 QAAQELAAEKEKISVLQNNYEKSQETFKQLQSDFY--GRESELLATRQDLKSVEEKLSLA 1059

Query: 396  LKSDLTDKTEILDRLKTERDQNEKLVQE----NRELQLQYLEQKQQLDELKKRIKLYNQE 451
             +  ++++ +I            KL+QE       L+    +++QQL E  K ++   +E
Sbjct: 1060 QEDLISNRNQI--------GNQNKLIQELKTAKATLEQDSAKKEQQLQERCKALQDIQKE 1111

Query: 452  NDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELE- 510
              +   EL             +   L+ + ++     K++ +   EL++   E+++E+  
Sbjct: 1112 KSLKEKEL-----------VNEKSKLAEIEEIKCRQEKEITKLNEELKSHKLESIKEITN 1160

Query: 511  -KTRNMLIMQHKIN-----KDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHK 564
             K    L++Q K+         +  VE   R  + L+   + + E+       + A++H 
Sbjct: 1161 LKDAKQLLIQQKLELQGKADSLKAAVEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLH- 1219

Query: 565  LEAQLKDIAYGTKQYK 580
              +++K+   G K+++
Sbjct: 1220 --SEIKEKEVGMKKHE 1233



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 113/531 (21%), Positives = 217/531 (40%), Gaps = 63/531 (11%)

Query: 29   ETSTTRTMKSRQAVSRVSRE--ELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLV 86
            +T+ T   K +     +  E   ++D+  ++ D     K    K+  K K     L +  
Sbjct: 835  QTTVTELQKVKMEKEALMTELSTVKDKLSKVSDSLKNSKSEFEKENQKGKAAILDLEKTC 894

Query: 87   NDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQL-QTQGY 145
             + K   +V      L    E+++ +E+ +E  H+L+ +  +++ +LI A+  L Q +  
Sbjct: 895  KELKHQLQVQM-ENTLKEQKELKKSLEKEKEASHQLKLELNSMQEQLIQAQNTLKQNEKE 953

Query: 146  RQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEAR 205
             Q    N+     +  +K  +   LQ   +  +  Q  ++        T+    L  E +
Sbjct: 954  EQQLQGNINELKQSSEQKKKQIEALQGELKIAV-LQKTELENKLQQQLTQAAQELAAE-K 1011

Query: 206  GEIRNLENVIQSQRGQIEELE-----HLAEILKTQLRRKENEIELSLLQLREQQATDQRS 260
             +I  L+N  +  +   ++L+       +E+L T+   K  E +LSL Q       +Q  
Sbjct: 1012 EKISVLQNNYEKSQETFKQLQSDFYGRESELLATRQDLKSVEEKLSLAQEDLISNRNQIG 1071

Query: 261  NIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLR-ISHDALMANGDELNMQLKE 319
            N    ++ +K  K  +E+ +A         QLQE+ + L+ I  +  +   + +N + K 
Sbjct: 1072 NQNKLIQELKTAKATLEQDSAKKEQ-----QLQERCKALQDIQKEKSLKEKELVNEKSKL 1126

Query: 320  QRLK--CCSLEKQLHSM--KFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSA-AH 374
              ++   C  EK++  +  +    ++E +++ I +L+  ++LL +   +L   A S  A 
Sbjct: 1127 AEIEEIKCRQEKEITKLNEELKSHKLESIKE-ITNLKDAKQLLIQQKLELQGKADSLKAA 1185

Query: 375  EEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQEN---------- 424
             EQ K  +Q LK Q+ + E  LK +  +K   L     E++   K  +EN          
Sbjct: 1186 VEQEKRNQQILKDQVKKEEEELKKEFIEKEAKLHSEIKEKEVGMKKHEENEAKLTMQITA 1245

Query: 425  ------------RELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQ 472
                        +  Q +  E ++Q D+L+  I +       N DE              
Sbjct: 1246 LNENLGTVKKEWQSSQRRVSELEKQTDDLRGEIAVLEATVQNNQDE-------------- 1291

Query: 473  KNGDLSFLVKVDSEINKDLERSMRELQATHAET---VQELEKTRNMLIMQH 520
            +   L   +K + EI K L+  + ELQ     T   VQEL +    L ++H
Sbjct: 1292 RRALLERCLKGEGEIEK-LQTKVLELQRKLDNTTAAVQELGRENQSLQIKH 1341


>gi|55770834 centromere protein F [Homo sapiens]
          Length = 3114

 Score = 90.9 bits (224), Expect = 7e-18
 Identities = 144/652 (22%), Positives = 294/652 (45%), Gaps = 111/652 (17%)

Query: 37   KSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKI-----------KRMATKLI-- 83
            K  QA+S +++ ELE++  +L+ E  LL + +   + ++           K +   L+  
Sbjct: 2042 KDSQALS-LTKCELENQIAQLNKEKELLVKESESLQARLSESDYEKLNVSKALEAALVEK 2100

Query: 84   -----RLVNDKKRYERVGGGPKRLGRDVEMEEMIE-QLQEKVHELEKQNETLKNRLISAK 137
                 RL + ++   ++  G ++L   +E +E  +  + EK+ E E++N++LK+++ + +
Sbjct: 2101 GEFALRLSSTQEEVHQLRRGIEKLRVRIEADEKKQLHIAEKLKERERENDSLKDKVENLE 2160

Query: 138  QQLQTQGYRQT----PYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMF 193
            ++LQ     Q        N ++ + T + +  E A       + +K  + D         
Sbjct: 2161 RELQMSEENQELVILDAENSKAEVETLKTQIEEMA-------RSLKVFELD--------- 2204

Query: 194  TKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQ 253
                   L   R E  NL   IQ ++GQ+ EL+ L    K+ L  KE     + +Q++E+
Sbjct: 2205 -------LVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQ----AEIQIKEE 2253

Query: 254  QATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDEL 313
              T         VEM  L  QL E + A++A+ G     QE  +    S D  +    +L
Sbjct: 2254 SKT--------AVEM--LQNQLKELNEAVAALCGD----QEIMKATEQSLDPPIEEEHQL 2299

Query: 314  NMQLKEQRLKCCSLEKQ----LHSMKFSERRIEELQDRINDLEKERELLKENYD-KLYDS 368
               +++ R +  + EK+    L  +K SE   + L+ R+ +LE+E E+ + N +    ++
Sbjct: 2300 RNSIEKLRARLEADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIARTNQEHAALEA 2359

Query: 369  AFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQ----------NE 418
              S    E  K K + +   +  LE  + +  ++K  + + L+ E+++           E
Sbjct: 2360 ENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFE 2419

Query: 419  KLVQENRELQLQYLEQ--------KQQLDELKKRI-KLYNQENDINADELS-----EALL 464
             ++QE  + ++Q  E+        + QL EL +R+  L+N +    A E +     E L 
Sbjct: 2420 NILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNLSSQVECLE 2479

Query: 465  LIKAQ-----KEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQ 519
            L KAQ      E KN  +     V+  I +++E   ++L+    +  +E+ + +N +  Q
Sbjct: 2480 LEKAQLLQGLDEAKNNYIVLQSSVNGLI-QEVEDGKQKLE----KKDEEISRLKNQIQDQ 2534

Query: 520  HK-INKDYQMEVEAVTRKMENLQ-QDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTK 577
             + ++K  Q+E E    K +NL+ ++  +++EQ + +L  + A    L+  L+ +    K
Sbjct: 2535 EQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSKNA---SLQDTLEVLQSSYK 2591

Query: 578  QYKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSEVLQ--ASGDK 627
              + + E+   D +   ++   +   E   +  ++++   +  LQ   SG+K
Sbjct: 2592 NLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEK 2643



 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 127/632 (20%), Positives = 278/632 (43%), Gaps = 69/632 (10%)

Query: 36   MKSRQAVSRVSREELE--DRFLRLHDENI-LLKQHARKQEDKIKRMATKLIRLVNDKKRY 92
            +K R+  +   ++++E  +R L++ +EN  L+   A   + +++ + T++  +    K +
Sbjct: 2142 LKERERENDSLKDKVENLERELQMSEENQELVILDAENSKAEVETLKTQIEEMARSLKVF 2201

Query: 93   ERVGGGPKRLGRDVEMEEMIEQLQEK---VHELEKQNETLKNRLISAKQ-QLQTQGYRQT 148
            E        +    E E + +Q+QEK   + EL+K   + K+ L   +Q ++Q +   +T
Sbjct: 2202 EL-----DLVTLRSEKENLTKQIQEKQGQLSELDKLLSSFKSLLEEKEQAEIQIKEESKT 2256

Query: 149  PYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEI 208
                +Q+++           G QE  +   +  D  + E  H +      + +E+ R  +
Sbjct: 2257 AVEMLQNQLKELNEAVAALCGDQEIMKATEQSLDPPIEEE-HQL-----RNSIEKLRARL 2310

Query: 209  RNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEM 268
               E        Q++E EH A++LK ++   E E+E++  +  ++ A  +  N +  VE 
Sbjct: 2311 EADEKKQLCVLQQLKESEHHADLLKGRVENLERELEIA--RTNQEHAALEAENSKGEVET 2368

Query: 269  IKLHKQLVEKSNALSAMEGKFIQLQEKQRTL---------RISHDALMANGDELNMQLKE 319
            +K   ++   + +L  +E   + ++ ++  L         RIS   ++ +  E  +Q KE
Sbjct: 2369 LKA--KIEGMTQSLRGLELDVVTIRSEKENLTNELQKEQERISELEIINSSFENILQEKE 2426

Query: 320  QRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWK 379
            Q  K    EK   +M+  + +++EL +R+  L  ++E  K     L      ++  E  +
Sbjct: 2427 QE-KVQMKEKSSTAMEMLQTQLKELNERVAALHNDQEACKAKEQNL------SSQVECLE 2479

Query: 380  LKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLD 439
            L++ QL   +  L+ A  + +  ++ +   ++   D  +KL +++ E+  +   Q Q  +
Sbjct: 2480 LEKAQL---LQGLDEAKNNYIVLQSSVNGLIQEVEDGKQKLEKKDEEIS-RLKNQIQDQE 2535

Query: 440  ELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQ 499
            +L  ++     E+ +  ++  E L  +  + EQK       ++V    N  L+ ++  LQ
Sbjct: 2536 QLVSKLSQVEGEHQLWKEQNLE-LRNLTVELEQK-------IQVLQSKNASLQDTLEVLQ 2587

Query: 500  ATHAETVQELEKTR-NMLIMQHKINK------DYQMEVEAVTRKMENLQQDYELKVEQYV 552
            +++     ELE T+ + +    K+NK      + Q E+  + +K   LQ++   +  +  
Sbjct: 2588 SSYKNLENELELTKMDKMSFVEKVNKMTAKETELQREMHEMAQKTAELQEELSGEKNRLA 2647

Query: 553  HLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENLFEIHIN 612
              L +    I   + QLK++     + K   + M  D V++ +  +  E  E    +H  
Sbjct: 2648 GELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQVEK-EGKVREEIAEYQLRLH-- 2704

Query: 613  KVTFSSEVLQASGDKEPVTFCTYAFYDFELQT 644
                     +A    + +   T   Y+ E+QT
Sbjct: 2705 ---------EAEKKHQALLLDTNKQYEVEIQT 2727



 Score = 77.4 bits (189), Expect = 8e-14
 Identities = 163/759 (21%), Positives = 304/759 (40%), Gaps = 117/759 (15%)

Query: 43   SRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRL 102
            ++V   E E    +  DE +       +   K   +  KL +L  D    +R      R 
Sbjct: 325  AKVELIEKEKVLNKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLS-CQRQNAESARC 383

Query: 103  GRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTP--YNNVQSRIN-- 158
              + +++E  ++ QE++   ++  +TL    I  K +L TQ  +Q    +N +Q+ ++  
Sbjct: 384  SLEQKIKEKEKEFQEELSRQQRSFQTLDQECIQMKARL-TQELQQAKNMHNVLQAELDKL 442

Query: 159  TGRRKANENAGLQECPRKGIK----FQDADVAETP---HPMFTKYGNSLL-----EEAR- 205
            T  ++  EN  L+E  +K  +    FQ + + E          K  N+LL     ++AR 
Sbjct: 443  TSVKQQLEN-NLEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKARE 501

Query: 206  -----GEIRNLENVIQSQRGQIEEL-------EHLAEILKTQLRRKENEIELSLLQLREQ 253
                  E++N++  +   +   EE+       E +   L+ ++ ++EN + L  L+L   
Sbjct: 502  VCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRDLQEKINQQENSLTLEKLKLAVA 561

Query: 254  QATDQRSNIRD-------NVEMI--KLHKQLVEKSNALSAMEGKFIQLQE--KQRTL--- 299
                QR   +D       ++E +  KL K   E    LSA+E K  + +E  +++TL   
Sbjct: 562  DLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSALELKKKEYEELKEEKTLFSC 621

Query: 300  -RISHDALMA--NGDELNMQLKEQRLKCCSLEKQLHSMKFSER-------------RIEE 343
             +  ++ L+     ++ N+Q K   L+ C   +Q+ S +++ER              I  
Sbjct: 622  WKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYNERVRTLEMDRENLSVEIRN 681

Query: 344  LQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWK-----LKEQQLKVQIAQLE---TA 395
            L + ++    E E  K  Y +L   A  +  + Q +     LK  QL  Q+  LE     
Sbjct: 682  LHNVLDSKSVEVETQKLAYMELQQKAEFSDQKHQKEIENMCLKTSQLTGQVEDLEHKLQL 741

Query: 396  LKSDLTDKTEILDRLKTERDQNEKLVQE-------NRELQLQYLEQKQQLDELKKRIKLY 448
            L +++ DK      L  E +    L++        N + Q   L   QQ         + 
Sbjct: 742  LSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTNEDHQRSLLAFDQQPAMHHSFANII 801

Query: 449  NQENDINADELSEALLLIKAQKEQKNG--------DLSFLVKVDSEINKDLERSMRELQA 500
             ++  +   E SE  L  +A +  KN          L F ++   ++N DL++   EL  
Sbjct: 802  GEQGSM-PSERSECRL--EADQSPKNSAILQNRVDSLEFSLESQKQMNSDLQKQCEELVQ 858

Query: 501  THAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAA 560
               E  + L K   M          +Q  V   ++++  LQ+D      Q V    + A 
Sbjct: 859  IKGEIEENLMKAEQM----------HQSFVAETSQRISKLQED--TSAHQNVVAETLSAL 906

Query: 561  RIHKLEAQLKDIAYGTKQYKF----KPEIMPDDSVDE---FDETIHLERGENLFEIHINK 613
               + E QL +    T+Q +     K   + +DS+ E     ET+ LE+ E    I +NK
Sbjct: 907  ENKEKELQLLNDKVETEQAEIQELKKSNHLLEDSLKELQLLSETLSLEKKEMSSIISLNK 966

Query: 614  VTFSSEVLQASGDKEPVTFCTYAFYDFELQTTPVVRGLHPEYNFTSQYLVHVNDLFLQYI 673
                 E+ Q +G  + +            +   +++      N+  +    +++L  QY 
Sbjct: 967  REI-EELTQENGTLKEIN------ASLNQEKMNLIQKSESFANYIDEREKSISELSDQYK 1019

Query: 674  QKNTITLEVHQAYSTEYETIAACQLKFHEILEKSGRIFC 712
            Q+  I L+  +     YE ++    K+    EK+ ++ C
Sbjct: 1020 QEKLILLQRCEETGNAYEDLSQ---KYKAAQEKNSKLEC 1055



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 129/581 (22%), Positives = 229/581 (39%), Gaps = 89/581 (15%)

Query: 44   RVSREELEDRFLRLHDENILLKQHARKQE-----DKIKRMATKLIRLVND-----KKRYE 93
            RV   E E    R + E+  L+    K E      KI+ M   L  L  D      ++  
Sbjct: 2337 RVENLERELEIARTNQEHAALEAENSKGEVETLKAKIEGMTQSLRGLELDVVTIRSEKEN 2396

Query: 94   RVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQ----GYRQTP 149
                  K   R  E+E +    +  + E E++   +K +  +A + LQTQ      R   
Sbjct: 2397 LTNELQKEQERISELEIINSSFENILQEKEQEKVQMKEKSSTAMEMLQTQLKELNERVAA 2456

Query: 150  YNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARG--- 206
             +N Q       +  +      E  +  +  Q  D A+  + +     N L++E      
Sbjct: 2457 LHNDQEACKAKEQNLSSQVECLELEKAQL-LQGLDEAKNNYIVLQSSVNGLIQEVEDGKQ 2515

Query: 207  -------EIRNLENVIQSQR------GQIEELEHLAEILKTQLRRKENEIELSLLQLREQ 253
                   EI  L+N IQ Q        Q+E    L +    +LR    E+E  +  L+ +
Sbjct: 2516 KLEKKDEEISRLKNQIQDQEQLVSKLSQVEGEHQLWKEQNLELRNLTVELEQKIQVLQSK 2575

Query: 254  QATDQRS---------NIRDNVEMIKLHKQ-LVEKSNALSAMEGKFIQLQEKQRTLRISH 303
             A+ Q +         N+ + +E+ K+ K   VEK N ++A E       E QR +   H
Sbjct: 2576 NASLQDTLEVLQSSYKNLENELELTKMDKMSFVEKVNKMTAKE------TELQREM---H 2626

Query: 304  DALMANGDELNMQLKEQRLKCCS-LEKQLHSMKFSERRIEELQDRINDLEKERELLKENY 362
            +       EL  +L  ++ +    L+  L  +K S+ +++EL    ++L+K  + + ++ 
Sbjct: 2627 EMAQKTA-ELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELTLENSELKKSLDCMHKDQ 2685

Query: 363  DKLYDSAFSAAHEEQWKLKEQQLKVQIAQLET---------ALKSDLTDKTEILDRLKTE 413
             +          E Q +L E + K Q   L+T           +  LT K E L   K E
Sbjct: 2686 VEKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYREKLTSKEECLSSQKLE 2745

Query: 414  RDQNEKLVQENRELQLQYLEQKQQLDELKK----RIKLYNQENDINADELSEALLLIKAQ 469
             D    L     EL        Q L+ELKK     +K  NQ               +K +
Sbjct: 2746 IDL---LKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQ---------------LKKE 2787

Query: 470  KEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQME 529
             E+  G +  L+K   ++ ++ E   +EL  +  +  QE +KT    +M  K++ +   E
Sbjct: 2788 NERAQGKMKLLIKSCKQLEEEKEILQKEL--SQLQAAQEKQKTGT--VMDTKVD-ELTTE 2842

Query: 530  VEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLK 570
            ++ +   +E   ++ +  +++Y  LL I   ++ K +  L+
Sbjct: 2843 IKELKETLEEKTKEADEYLDKYCSLL-ISHEKLEKAKEMLE 2882



 Score = 65.9 bits (159), Expect = 2e-10
 Identities = 93/529 (17%), Positives = 229/529 (43%), Gaps = 37/529 (6%)

Query: 37   KSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVG 96
            K  Q  + ++ E+L+     L  +    +   +K+E  I+++  KL +   + K      
Sbjct: 543  KINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKALLSAL 602

Query: 97   GGPKRLGRDVEMEEMI-----EQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYN 151
               K+   +++ E+ +      + ++ + ++E + E L++++   +  L+TQ  +   YN
Sbjct: 603  ELKKKEYEELKEEKTLFSCWKSENEKLLTQMESEKENLQSKINHLETCLKTQQIKSHEYN 662

Query: 152  NVQSRINTGRRKAN-ENAGLQEC-PRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIR 209
                 +   R   + E   L      K ++ +   +A        ++ +   ++ + EI 
Sbjct: 663  ERVRTLEMDRENLSVEIRNLHNVLDSKSVEVETQKLAYMELQQKAEFSD---QKHQKEIE 719

Query: 210  NLENVIQSQRGQIEELEHLAEILKTQLRRKE---NEIELSLLQLREQQATDQRSNIRDNV 266
            N+        GQ+E+LEH  ++L  ++  K+    ++      LR+   +   S + +  
Sbjct: 720  NMCLKTSQLTGQVEDLEHKLQLLSNEIMDKDRCYQDLHAEYESLRDLLKSKDASLVTN-- 777

Query: 267  EMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCS 326
               + H++ +   +   AM   F  +  +Q        ++ +   E  ++  +       
Sbjct: 778  ---EDHQRSLLAFDQQPAMHHSFANIIGEQ-------GSMPSERSECRLEADQSPKNSAI 827

Query: 327  LEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLK 386
            L+ ++ S++FS   +E  +   +DL+K+ E L +   ++ ++   A    Q  + E   +
Sbjct: 828  LQNRVDSLEFS---LESQKQMNSDLQKQCEELVQIKGEIEENLMKAEQMHQSFVAETSQR 884

Query: 387  VQIAQLETALKSDLTDKTEILDRLKTERDQ----NEKLVQENRELQLQYLEQKQQLDELK 442
            +   Q +T+   ++    E L  L+ +  +    N+K+  E  E+Q +  +    L++  
Sbjct: 885  ISKLQEDTSAHQNVV--AETLSALENKEKELQLLNDKVETEQAEIQ-ELKKSNHLLEDSL 941

Query: 443  KRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATH 502
            K ++L ++   +   E+S  + L K + E+   +   L ++++ +N++ + ++ +   + 
Sbjct: 942  KELQLLSETLSLEKKEMSSIISLNKREIEELTQENGTLKEINASLNQE-KMNLIQKSESF 1000

Query: 503  AETVQELEKTRNMLIMQHKINKDYQME-VEAVTRKMENLQQDYELKVEQ 550
            A  + E EK+ + L  Q+K  K   ++  E      E+L Q Y+   E+
Sbjct: 1001 ANYIDEREKSISELSDQYKQEKLILLQRCEETGNAYEDLSQKYKAAQEK 1049



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 86/400 (21%), Positives = 179/400 (44%), Gaps = 63/400 (15%)

Query: 65   KQHARKQEDKIKRMATKLI---RLVNDKKRYERVGGGPKRLGRD--VEMEEMIEQLQEKV 119
            KQ   K++++I R+  ++    +LV+   + E    G  +L ++  +E+  +  +L++K+
Sbjct: 2514 KQKLEKKDEEISRLKNQIQDQEQLVSKLSQVE----GEHQLWKEQNLELRNLTVELEQKI 2569

Query: 120  HELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIK 179
              L+ +N +L++ L             Q+ Y N+++ +     K ++ + +++  +   K
Sbjct: 2570 QVLQSKNASLQDTL----------EVLQSSYKNLENELEL--TKMDKMSFVEKVNKMTAK 2617

Query: 180  FQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRK 239
              + ++    H M  K    L EE  GE   L   +Q     +EE++   + LK +L  +
Sbjct: 2618 --ETELQREMHEMAQKTAE-LQEELSGEKNRLAGELQLL---LEEIKSSKDQLK-ELTLE 2670

Query: 240  ENEIELSLLQLREQQATDQRSNIRDNV--------EMIKLHKQLVEKSNALSAME----- 286
             +E++ SL  + + Q  ++   +R+ +        E  K H+ L+  +N    +E     
Sbjct: 2671 NSELKKSLDCMHKDQV-EKEGKVREEIAEYQLRLHEAEKKHQALLLDTNKQYEVEIQTYR 2729

Query: 287  GKFIQLQEKQRTLRISHDALMANGDELNMQLKE-----QRLKCCSLE--KQLHSMKFSER 339
             K    +E   + ++  D L ++ +ELN  LK      + LK   ++  K ++ +K    
Sbjct: 2730 EKLTSKEECLSSQKLEIDLLKSSKEELNNSLKATTQILEELKKTKMDNLKYVNQLKKENE 2789

Query: 340  RIEE----LQDRINDLEKERELLKENYDKLYDSAFSAAHEEQ-----WKLKEQQLKVQIA 390
            R +     L      LE+E+E+L++   +L      AA E+Q        K  +L  +I 
Sbjct: 2790 RAQGKMKLLIKSCKQLEEEKEILQKELSQL-----QAAQEKQKTGTVMDTKVDELTTEIK 2844

Query: 391  QLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQ 430
            +L+  L+    +  E LD+  +    +EKL +    L+ Q
Sbjct: 2845 ELKETLEEKTKEADEYLDKYCSLLISHEKLEKAKEMLETQ 2884



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 81/373 (21%), Positives = 157/373 (42%), Gaps = 59/373 (15%)

Query: 227 HLAEILKTQ---LRRKENEIELSLLQLREQQATDQRSNIRD-NVEMIKLHKQLVEKSNAL 282
           HL + LK Q   LR K NE+EL L Q  E++   Q +  ++  +++ K   +L+EK   L
Sbjct: 278 HLLDQLKAQNQELRNKINELELRL-QGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVL 336

Query: 283 SAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKC----CSLEKQLHSMKFSE 338
           +    + ++   +       + AL     +L   L  QR       CSLE+++       
Sbjct: 337 NKCRDELVRTTAQYDQASTKYTALEQKLKKLTEDLSCQRQNAESARCSLEQKIK------ 390

Query: 339 RRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEE--QWKLKEQQLKVQIAQLETAL 396
                        EKE+E  +E   +    +F    +E  Q K +  Q   Q   +   L
Sbjct: 391 -------------EKEKEFQEELSRQ--QRSFQTLDQECIQMKARLTQELQQAKNMHNVL 435

Query: 397 KSDLTDKTEILDRLKTERDQ-NEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDIN 455
           +++L   T +  +L+   ++  +KL +  +  Q   +++    +EL++ ++   +EN+  
Sbjct: 436 QAELDKLTSVKQQLENNLEEFKQKLCRAEQAFQASQIKE----NELRRSMEEMKKENN-- 489

Query: 456 ADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNM 515
                    L+K+  EQK  ++  L      I + L +S    +   A+   +    R+ 
Sbjct: 490 ---------LLKSHSEQKAREVCHLEAELKNIKQCLNQSQNFAEEMKAKNTSQETMLRD- 539

Query: 516 LIMQHKIN-KDYQMEVE------AVTRKMENLQQDYELKVEQYVHLLDIRAARIHK-LEA 567
             +Q KIN ++  + +E      A   K  +  QD   K E ++  L+ + ++  K  +A
Sbjct: 540 --LQEKINQQENSLTLEKLKLAVADLEKQRDCSQDLLKKREHHIEQLNDKLSKTEKESKA 597

Query: 568 QLKDIAYGTKQYK 580
            L  +    K+Y+
Sbjct: 598 LLSALELKKKEYE 610



 Score = 52.4 bits (124), Expect = 3e-06
 Identities = 83/328 (25%), Positives = 148/328 (45%), Gaps = 22/328 (6%)

Query: 230  EILKTQLRRKENEIE-LSLLQLREQQATDQRSNIRDNVEM-IKLHKQLVEKSNALSA-ME 286
            +I   QLR KE   E L LL + E +     S + +  E+  KLH Q V+    + A +E
Sbjct: 1768 DIHNLQLRVKETSNENLRLLHVIEDRDRKVESLLNEMKELDSKLHLQEVQLMTKIEACIE 1827

Query: 287  GKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQD 346
             + I  + K+    +S      + D   +  + +  +  + + ++H+ K S   I +   
Sbjct: 1828 LEKIVGELKKENSDLSEKLEYFSCDHQELLQRVETSEGLNSDLEMHADKSSREDIGDNVA 1887

Query: 347  RINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEI 406
            ++ND  KER L  EN      S  ++   E   L+     VQ  +L   L+ D  +K ++
Sbjct: 1888 KVNDSWKERFLDVENELSRIRSEKASIEHEALYLEADLEVVQTEKL--CLEKDNENKQKV 1945

Query: 407  LDRLKTERDQNEKLVQENREL--QLQYLEQK-QQLDELKKRIKLYNQENDINADELSEAL 463
            +  L+ E      +  E  +L  +L  + +K   LD+L +++K   QE + +  E    +
Sbjct: 1946 IVCLEEEL---SVVTSERNQLRGELDTMSKKTTALDQLSEKMKEKTQELESHQSECLHCI 2002

Query: 464  LLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQ-HKI 522
             + +A+ ++K   L  L    SE+ KD      +LQ+   ++ Q L  T+  L  Q  ++
Sbjct: 2003 QVAEAEVKEKTELLQTLSSDVSELLKDKTHLQEKLQSLEKDS-QALSLTKCELENQIAQL 2061

Query: 523  NKDYQMEVEAVTRKMENLQ-----QDYE 545
            NK    E E + ++ E+LQ      DYE
Sbjct: 2062 NK----EKELLVKESESLQARLSESDYE 2085



 Score = 48.1 bits (113), Expect = 5e-05
 Identities = 104/510 (20%), Positives = 210/510 (41%), Gaps = 108/510 (21%)

Query: 106  VEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKAN 165
            V++E M+   + K+ E EK+ E L++ L + +  L+T        +N+Q        ++ 
Sbjct: 1211 VQLEAMLRNKELKLQESEKEKECLQHELQTIRGDLET--------SNLQD------MQSQ 1256

Query: 166  ENAGLQECPRKGIKFQDADVAETPHPMFTKY--GNSLLEEARGEIRNLENVIQSQRGQIE 223
            E +GL++C        + D  E       KY  G   L  ++ +  +L+  +Q+   ++ 
Sbjct: 1257 EISGLKDC--------EIDAEE-------KYISGPHELSTSQNDNAHLQCSLQTTMNKLN 1301

Query: 224  ELEHLAEILKTQLRRKENEIELSLLQ--LREQQATDQRSNIRDNVEMIK-----LHKQLV 276
            ELE + EIL+ +      E+  S  +     ++  ++   + + V+++      LH +LV
Sbjct: 1302 ELEKICEILQAEKYELVTELNDSRSECITATRKMAEEVGKLLNEVKILNDDSGLLHGELV 1361

Query: 277  EKSNALSAMEGKFIQLQEKQRTLRI-------SHDALMANGDELNMQLKEQRLKCCSLE- 328
            E         G+F +   +Q  + +       S++ L  +  E+ M   E + K  SL+ 
Sbjct: 1362 E-----DIPGGEFGEQPNEQHPVSLAPLDESNSYEHLTLSDKEVQMHFAELQEKFLSLQS 1416

Query: 329  --KQLHSMKFS-ERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKE--- 382
              K LH        ++ ELQ  ++ L+ E  +L  N   L +       E Q  L+E   
Sbjct: 1417 EHKILHDQHCQMSSKMSELQTYVDSLKAENLVLSTN---LRNFQGDLVKEMQLGLEEGLV 1473

Query: 383  QQLKVQIAQLETALKS-----------DLTDKTEILDRLKTERDQNEKLVQE--NRELQL 429
              L        ++L S           + T    +L  L+     N+  V E     LQ 
Sbjct: 1474 PSLSSSCVPDSSSLSSLGDSSFYRALLEQTGDMSLLSNLEGAVSANQCSVDEVFCSSLQE 1533

Query: 430  QYLEQKQQ-------LDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVK 482
            + L +K+        ++EL+   ++Y Q    + ++L E +   ++Q   KN        
Sbjct: 1534 ENLTRKETPSAPAKGVEELESLCEVYRQ----SLEKLEEKM---ESQGIMKN-------- 1578

Query: 483  VDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQ 542
                      + ++EL+   +   QEL+  R   + +   N+ +Q ++ +VT +ME+   
Sbjct: 1579 ----------KEIQELEQLLSSERQELDCLRKQYLSE---NEQWQQKLTSVTLEMESKLA 1625

Query: 543  DYELKVEQYVHLLDIRAARIHKLEAQLKDI 572
              + + EQ    L++   ++  L+   + +
Sbjct: 1626 AEKKQTEQLSLELEVARLQLQGLDLSSRSL 1655



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 99/534 (18%), Positives = 199/534 (37%), Gaps = 94/534 (17%)

Query: 117 EKVHELEKQNETLKNRLISAKQQLQT-QGYRQTPYNNVQSRINTGRRKANENAGLQECPR 175
           +K+ ELE Q + LK      + QL + +   Q     V++    G     EN  L E   
Sbjct: 18  QKIQELEGQLDKLKKEKQQRQFQLDSLEAALQKQKQKVENEKTEGTNLKRENQRLME--- 74

Query: 176 KGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQ 235
                    + E+      K  +        E++  E+ +  Q GQ+   +   E L+ +
Sbjct: 75  ---------ICESLEKTKQKISH--------ELQVKESQVNFQEGQLNSGKKQIEKLEQE 117

Query: 236 LRRKENEIELSLLQLREQQATDQRSNIRDNV-----------------EMIKLHKQLVEK 278
           L+R ++E+E S    +    +    N    +                 ++ + + + VE+
Sbjct: 118 LKRCKSELERSQQAAQSADVSLNPCNTPQKIFTTPLTPSQYYSGSKYEDLKEKYNKEVEE 177

Query: 279 SNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSE 338
              L A E K +Q ++  +TL     A M + D    Q           +   H    S+
Sbjct: 178 RKRLEA-EVKALQAKKASQTL---PQATMNHRDIARHQASSSVFSWQQEKTPSHLSSNSQ 233

Query: 339 RRIEELQDRINDLEKERELL----------KENYDKLYDSAFSAAHEEQWKLKEQQLKVQ 388
           R         +    E+E+           ++     +D++ S    +Q K + Q+L+ +
Sbjct: 234 RTPIRRDFSASYFSGEQEVTPSRSTLQIGKRDANSSFFDNSSSPHLLDQLKAQNQELRNK 293

Query: 389 IAQLETAL-------KSDLTDKTEI---LDRLKTERDQNEKLVQENRE----LQLQYLEQ 434
           I +LE  L       K  +    E+   L++ K E  + EK++ + R+       QY + 
Sbjct: 294 INELELRLQGHEKEMKGQVNKFQELQLQLEKAKVELIEKEKVLNKCRDELVRTTAQYDQA 353

Query: 435 KQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERS 494
             +   L++++K   ++          A    +   EQK      + + + E  ++L R 
Sbjct: 354 STKYTALEQKLKKLTEDLSCQRQNAESA----RCSLEQK------IKEKEKEFQEELSRQ 403

Query: 495 MRELQATHAETV-------QELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELK 547
            R  Q    E +       QEL++ +NM    H +       ++A   K+ +++Q  E  
Sbjct: 404 QRSFQTLDQECIQMKARLTQELQQAKNM----HNV-------LQAELDKLTSVKQQLENN 452

Query: 548 VEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLE 601
           +E++   L          + +  ++    ++ K +  ++   S  +  E  HLE
Sbjct: 453 LEEFKQKLCRAEQAFQASQIKENELRRSMEEMKKENNLLKSHSEQKAREVCHLE 506



 Score = 40.0 bits (92), Expect = 0.014
 Identities = 62/309 (20%), Positives = 126/309 (40%), Gaps = 31/309 (10%)

Query: 28   QETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVN 87
            +ET   R M      +   +EEL     RL  E  LL +  +  +D++K +      L N
Sbjct: 2617 KETELQREMHEMAQKTAELQEELSGEKNRLAGELQLLLEEIKSSKDQLKELT-----LEN 2671

Query: 88   DKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQ 147
             + +         ++ ++ ++ E I + Q ++HE EK+++ L   L+   +Q + +    
Sbjct: 2672 SELKKSLDCMHKDQVEKEGKVREEIAEYQLRLHEAEKKHQAL---LLDTNKQYEVE---- 2724

Query: 148  TPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEE-ARG 206
                     I T R K           +  I    +   E  + +  K    +LEE  + 
Sbjct: 2725 ---------IQTYREKLTSKEECLSSQKLEIDLLKSSKEELNNSL--KATTQILEELKKT 2773

Query: 207  EIRNLENVIQSQRGQIEELEHLAEILKT--QLRRKENEIELSLLQLREQQATDQRSNIRD 264
            ++ NL+ V Q ++        +  ++K+  QL  ++  ++  L QL+  Q   +   + D
Sbjct: 2774 KMDNLKYVNQLKKENERAQGKMKLLIKSCKQLEEEKEILQKELSQLQAAQEKQKTGTVMD 2833

Query: 265  NVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKC 324
              ++ +L  ++ E    L     +  +  +K  +L ISH+ L    ++    L+ Q    
Sbjct: 2834 -TKVDELTTEIKELKETLEEKTKEADEYLDKYCSLLISHEKL----EKAKEMLETQVAHL 2888

Query: 325  CSLEKQLHS 333
            CS + +  S
Sbjct: 2889 CSQQSKQDS 2897


>gi|148762940 DVL-binding protein DAPLE [Homo sapiens]
          Length = 2028

 Score = 87.4 bits (215), Expect = 8e-17
 Identities = 126/559 (22%), Positives = 244/559 (43%), Gaps = 51/559 (9%)

Query: 39  RQAVSRVSREELEDRFLR--LHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVG 96
           R+  +RV R ELE    +  LHD +    +    +ED I  + TK +         E++ 
Sbjct: 319 REKANRVERLELELTRCKEKLHDVDFYKARMEELREDNIILIETKAML-------EEQLT 371

Query: 97  GGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSR 156
               R  +  E+E+   QL+ K+H+LE   +T K R+    ++       Q    N  + 
Sbjct: 372 AARARGDKVHELEKENLQLKSKLHDLELDRDTDKKRIEELLEENMVLEIAQKQSMNESAH 431

Query: 157 INTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQ 216
           +     + ++NA L +  RK   F+  + A +      K   SL    +G +R+   V++
Sbjct: 432 LGWELEQLSKNADLSDASRKSFVFELNECASSRILKLEKENQSLQSTIQG-LRDASLVLE 490

Query: 217 S---QRGQIEELEH----LAEILKTQLRRKENE------IELSLLQLREQQATDQRSNIR 263
               + G++E+  H      E L+TQL R++        +   L++ +EQ  +D  +   
Sbjct: 491 ESGLKCGELEKENHQLSKKIEKLQTQLEREKQSNQDLETLSEELIREKEQLQSDMETLKA 550

Query: 264 DNVEMIKLHKQLVEKSNAL--SAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQR 321
           D    IK  +Q  +  N    S  E   +  + + + +   + AL     E N +L +  
Sbjct: 551 DKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEANGKLSQLE 610

Query: 322 LKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLK 381
            +   L + L   K    R E+L+  +  L++E   L      L       A E+   L+
Sbjct: 611 FEKRQLHRDLEQAKEKGERAEKLERELQRLQEENGRLARKVTSL-----ETATEKVEALE 665

Query: 382 EQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDEL 441
            +   +Q+ +  T  KS        LD L+    Q E L ++N++L  + LE ++ ++ +
Sbjct: 666 HESQGLQL-ENRTLRKS--------LDTLQNVSLQLEGLERDNKQLDAENLELRRLVETM 716

Query: 442 K------KRIKLYNQENDINADELSEALLLIKA-QKEQKNGDLSF--LVKVDSEINKDLE 492
           +       +++  NQ+ +   +EL + + L+KA  K+ +  +LS+  +   +  + + LE
Sbjct: 717 RFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSERLELSYQSVSAENLRLQQSLE 776

Query: 493 RSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYV 552
            S  + Q   +E + ELE  R  L    +  +    ++E   +  + L+Q+   ++E+  
Sbjct: 777 SSSHKTQTLESE-LGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEV-AQLEKDK 834

Query: 553 HLLDIRAARIHKLEAQLKD 571
            LL+  A R+ + + +LKD
Sbjct: 835 KLLEKEAKRLWQ-QVELKD 852



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 133/653 (20%), Positives = 270/653 (41%), Gaps = 92/653 (14%)

Query: 111  MIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNN-----VQSRINTGRRKAN 165
            ++E+   K  ELEK+N  L  ++    ++LQTQ  R+   N       +  I    +  +
Sbjct: 488  VLEESGLKCGELEKENHQLSKKI----EKLQTQLEREKQSNQDLETLSEELIREKEQLQS 543

Query: 166  ENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSL------LEEARGEIRNLENVIQSQR 219
            +   L+    + IK  + +       M++    S       +++   E + L   +    
Sbjct: 544  DMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQVSSEARMKDVEKENKALHQTVTEAN 603

Query: 220  GQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKS 279
            G++ +LE     L   L + + + E +    RE Q   +     +N  + +    L   +
Sbjct: 604  GKLSQLEFEKRQLHRDLEQAKEKGERAEKLERELQRLQE-----ENGRLARKVTSLETAT 658

Query: 280  NALSAMEGKFIQLQEKQRTLRISHDALMANGDEL------NMQLKEQRLKCCSLEKQLHS 333
              + A+E +   LQ + RTLR S D L     +L      N QL  + L+   L + + +
Sbjct: 659  EKVEALEHESQGLQLENRTLRKSLDTLQNVSLQLEGLERDNKQLDAENLE---LRRLVET 715

Query: 334  MKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLE 393
            M+F+  ++ +++     LE+E+E L++N D L          E+ +L  Q +  +  +L+
Sbjct: 716  MRFTSTKLAQMERENQQLEREKEELRKNVDLL---KALGKKSERLELSYQSVSAENLRLQ 772

Query: 394  TALKSDLTDKTEILDRLKTERDQNEKLVQENREL------QLQYLEQ-----KQQLDELK 442
             +L+S  + KT+ L+    E +   + ++ + E       QL+  E+     +Q++ +L+
Sbjct: 773  QSLESS-SHKTQTLESELGELEAERQALRRDLEALRLANAQLEGAEKDRKALEQEVAQLE 831

Query: 443  KRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVK----VDSEIN---------K 489
            K  KL  +E    A  L + + L  A  +     LS + K    +D E+          K
Sbjct: 832  KDKKLLEKE----AKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKELARCRDAAGKLK 887

Query: 490  DLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVE 549
            +LE+  R+L        + L   R  L+++   ++    E++ +++++E +  + EL ++
Sbjct: 888  ELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQELEKVGLNRELLLQ 947

Query: 550  Q--------YVHL-----------LDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDS 590
            +        Y  L           L ++  +I  LEAQ+++ A   +Q + + +++  + 
Sbjct: 948  EDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQMEEKASLNRQLESELQMLKKEC 1007

Query: 591  VDEFDETIHLERGE-----NLFEIHINKVTFSSEVLQASG-DKEPVTFCTYAFYDFELQT 644
                 ET+   +GE     N F+    K   S +  +A G   +  T       D  ++ 
Sbjct: 1008 -----ETLRQNQGEGQHLQNSFKHPAGKTAASHQGKEAWGPGHKEATMELLRVKDRAIEL 1062

Query: 645  TPVVRGLHPEYNFTSQYLVHVNDLFLQYIQKNTITLEVHQAYSTEYETIAACQ 697
                  L  E     + L H+    + +     +TL+   A+  E+ T    Q
Sbjct: 1063 ERNNAALQAEKQLLKEQLQHLETQNVTF-SSQILTLQKQSAFLQEHNTTLQTQ 1114



 Score = 65.1 bits (157), Expect = 4e-10
 Identities = 111/566 (19%), Positives = 244/566 (43%), Gaps = 76/566 (13%)

Query: 41   AVSRVSREELEDRFLR-----LHDENILLKQHARK---QEDKIKRMATKLIRLVNDKKRY 92
            A SR+ + E E++ L+     L D +++L++   K    E +  +++ K+ +L    +R 
Sbjct: 461  ASSRILKLEKENQSLQSTIQGLRDASLVLEESGLKCGELEKENHQLSKKIEKLQTQLERE 520

Query: 93   ERVGGGPKRLGRDVEMEEMIEQLQE-----------KVHELEKQNETLKNRLISAKQQLQ 141
            ++     + L  ++  E+  EQLQ            ++ +LE++ + L   + S +++ Q
Sbjct: 521  KQSNQDLETLSEELIREK--EQLQSDMETLKADKARQIKDLEQEKDHLNRAMWSLRERSQ 578

Query: 142  TQGY-RQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSL 200
                 R          ++    +AN      E  ++ +  +D + A+       K    L
Sbjct: 579  VSSEARMKDVEKENKALHQTVTEANGKLSQLEFEKRQLH-RDLEQAKEKGERAEKLEREL 637

Query: 201  --LEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQ---LRRKENEIELSLLQLREQQA 255
              L+E  G +      +++   ++E LEH ++ L+ +   LR+  + ++   LQL E   
Sbjct: 638  QRLQEENGRLARKVTSLETATEKVEALEHESQGLQLENRTLRKSLDTLQNVSLQL-EGLE 696

Query: 256  TDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELN- 314
             D +    +N+E+ +L + +   S  L+ ME +  QL+ ++  LR + D L A G +   
Sbjct: 697  RDNKQLDAENLELRRLVETMRFTSTKLAQMERENQQLEREKEELRKNVDLLKALGKKSER 756

Query: 315  MQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLE---------------------- 352
            ++L  Q +   +L  Q  S++ S  + + L+  + +LE                      
Sbjct: 757  LELSYQSVSAENLRLQ-QSLESSSHKTQTLESELGELEAERQALRRDLEALRLANAQLEG 815

Query: 353  --KERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILD-- 408
              K+R+ L++   +L         E +   ++ +LK  +    TA  S +  ++  LD  
Sbjct: 816  AEKDRKALEQEVAQLEKDKKLLEKEAKRLWQQVELKDAVLDDSTAKLSAVEKESRALDKE 875

Query: 409  --RLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRI---KLYNQENDINADELSEAL 463
              R +    + ++L ++NR+L  Q     + L  L++ +   KL +Q+     D+LS+ L
Sbjct: 876  LARCRDAAGKLKELEKDNRDLTKQVTVHARTLTTLREDLVLEKLKSQQLSSELDKLSQEL 935

Query: 464  LLIKAQKEQKNGDLSFLVKVDSEINKDLE------RSMRELQATHAETVQELEKTRNMLI 517
              +   +E        L+  + +   D +      R+   L+ T A   +++      + 
Sbjct: 936  EKVGLNRE--------LLLQEDDSGSDTKYKILEGRNESALKTTLAMKEEKIVLLEAQME 987

Query: 518  MQHKINKDYQMEVEAVTRKMENLQQD 543
             +  +N+  + E++ + ++ E L+Q+
Sbjct: 988  EKASLNRQLESELQMLKKECETLRQN 1013



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 81/352 (23%), Positives = 157/352 (44%), Gaps = 57/352 (16%)

Query: 114  QLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKA----NENAG 169
            +++++  ELE+ N  L+      K+QLQ   + +T      S+I T ++++      N  
Sbjct: 1054 RVKDRAIELERNNAALQAEKQLLKEQLQ---HLETQNVTFSSQILTLQKQSAFLQEHNTT 1110

Query: 170  LQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLA 229
            LQ    K ++ +++ ++     +  +Y    L +     +  EN  +S + Q E+L    
Sbjct: 1111 LQTQTAK-LQVENSTLSSQSAALTAQY---TLLQNHHTAKETEN--ESLQRQQEQLTAAY 1164

Query: 230  EILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKF 289
            E L   L+  E+     L  L E+Q+ +  + IR +  +  LH+ L  +   L    G  
Sbjct: 1165 EAL---LQDHEH-----LGTLHERQSAEYEALIRQHSCLKTLHRNLELEHKELGERHGDM 1216

Query: 290  I----QLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQ 345
            +    +L+E+++ L    +AL           +EQR    ++ +         +R+    
Sbjct: 1217 LKRKAELEEREKVLTTEREALQ----------QEQRTNALAMGEN--------QRLRGEL 1258

Query: 346  DRIN----DLEKERELLKENYDKLYDSAFSAAHE-EQWKLKEQQLKVQIAQLETALKSDL 400
            DR+N     L+ E E L  +  +L  S  +A  E  +W+ +  +LK Q   ++ +L + L
Sbjct: 1259 DRVNFLHHQLKGEYEELHAHTKELKTSLNNAQLELNRWQARFDELKEQHQTMDISL-TKL 1317

Query: 401  TDKTEILDRLKTERDQN--------EKLVQENRELQLQYLEQKQQLDELKKR 444
             +  E+L RLK   ++         + L Q+N+ L  Q +E K+Q  E +K+
Sbjct: 1318 DNHCELLSRLKGNLEEENHHLLSQIQLLSQQNQMLLEQNMENKEQYHEEQKQ 1369



 Score = 33.9 bits (76), Expect = 0.99
 Identities = 37/156 (23%), Positives = 74/156 (47%), Gaps = 18/156 (11%)

Query: 202  EEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSN 261
            +  RGE+  +  +    +G+ EEL    + LKT L     ++EL+  Q R  +  +Q   
Sbjct: 1252 QRLRGELDRVNFLHHQLKGEYEELHAHTKELKTSLNNA--QLELNRWQARFDELKEQHQT 1309

Query: 262  IRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDEL----NMQL 317
            +  ++  +  H +L      LS ++G    L+E+   L +S   L++  +++    NM+ 
Sbjct: 1310 MDISLTKLDNHCEL------LSRLKG---NLEEENHHL-LSQIQLLSQQNQMLLEQNMEN 1359

Query: 318  KEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEK 353
            KEQ  +    ++ +  +    R  E+L+++I D  K
Sbjct: 1360 KEQYHE--EQKQYIDKLNALRRHKEKLEEKIMDQYK 1393


>gi|50897852 coiled-coil domain containing 88A isoform 2 [Homo
           sapiens]
          Length = 1843

 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 130/588 (22%), Positives = 261/588 (44%), Gaps = 84/588 (14%)

Query: 48  EELEDRFLRLHDENILLKQHARKQE------DKIKRMATKLIRLVNDKKRY-------ER 94
           E++E    RL  EN+ L   AR         D ++  A ++ +L ++  RY       E 
Sbjct: 282 EQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEF 341

Query: 95  VGGGPKRLGRD----VEMEEMIE-QLQ------EKVHELEKQNETLKNRLISAK------ 137
                + L  D    +E + M+E QL+      +K+HELEK+N  LK +L   +      
Sbjct: 342 YKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMD 401

Query: 138 --------QQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETP 189
                   ++  T    Q    +    +     + +  + L E P+K +  +  ++  + 
Sbjct: 402 RKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSS- 460

Query: 190 HPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEI--ELSL 247
             +  +  N  L +   E+R   + ++    +I ++E   + L  ++   ENEI  E   
Sbjct: 461 RLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQS 520

Query: 248 LQ--------LREQQATDQRS--NIRDNVE-MIKLHKQLVEKSN--ALSAMEGKFIQLQE 294
           LQ        L +++A  +++   +R+N E  IK+ +Q  E  N    S  +   I  + 
Sbjct: 521 LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA 580

Query: 295 KQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKE 354
           + + +   +  L  +  E + +L +   +   ++K+L   K    R EEL++ ++ LEKE
Sbjct: 581 RVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKE 640

Query: 355 RELLKENYD--KLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKT 412
            ELL++     K+      A  +E  +L+ +  K++                + LD  K 
Sbjct: 641 NELLQKKITNLKITCEKIEALEQENSELERENRKLK----------------KTLDSFKN 684

Query: 413 ERDQNEKLVQENRELQLQYLEQKQQLDELK------KRIKLYNQENDINADELSEALLLI 466
              Q E L +EN +L  + LE ++ ++ LK       +++L N+E +   ++L + L L+
Sbjct: 685 LTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL 744

Query: 467 KAQ-KEQKNGDLSF--LVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKIN 523
           KA  K+ +  ++S+  L   +  + K LE S +++Q   +E +Q+LE     L    +  
Sbjct: 745 KASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESE-LQDLEMENQTLQKNLEEL 803

Query: 524 KDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKD 571
           K     +E + ++ ++L+Q+   ++E+    L+    R+ + +A++KD
Sbjct: 804 KISSKRLEQLEKENKSLEQETS-QLEKDKKQLEKENKRLRQ-QAEIKD 849



 Score = 81.3 bits (199), Expect = 5e-15
 Identities = 114/520 (21%), Positives = 229/520 (44%), Gaps = 86/520 (16%)

Query: 34   RTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYE 93
            +T+ S +  S++S E    R   +  EN +L        + IK  ++KL ++  +K++ +
Sbjct: 565  QTVSSLRQRSQISAEA---RVKDIEKENKIL-------HESIKETSSKLSKIEFEKRQIK 614

Query: 94   RVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNV 153
                  K L    E  E  E+L+ ++H LEK+NE L+ ++                  N+
Sbjct: 615  ------KELEHYKEKGERAEELENELHHLEKENELLQKKI-----------------TNL 651

Query: 154  QSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLEN 213
            +           EN+ L+   RK  K  D+    T      +  NS L+E   E+R    
Sbjct: 652  KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRR--- 708

Query: 214  VIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHK 273
                    +E L             K   ++++ LQL  ++   ++  ++  +E++K   
Sbjct: 709  -------NVESL-------------KCASMKMAQLQLENKELESEKEQLKKGLELLKASF 748

Query: 274  QLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHS 333
            +  E+     + +G  I+ Q  Q+TL  S+  +     +L  +L++  ++  +L+K L  
Sbjct: 749  KKTERLEV--SYQGLDIENQRLQKTLENSNKKIQ----QLESELQDLEMENQTLQKNLEE 802

Query: 334  MKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLK---VQIA 390
            +K S +R+E+L+     LE+E   L++  DK      +    +Q ++K+  L+   V+I 
Sbjct: 803  LKISSKRLEQLEKENKSLEQETSQLEK--DKKQLEKENKRLRQQAEIKDTTLEENNVKIG 860

Query: 391  QLE---TALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKL 447
             LE     L  ++    E   RLK    +N++LV +   + ++ L   ++ D + +++K 
Sbjct: 861  NLEKENKTLSKEIGIYKESCVRLKELEKENKELV-KRATIDIKTLVTLRE-DLVSEKLKT 918

Query: 448  YNQENDINADELSEALLLIKAQKE-----QKNGDLSFLVKVDSEINKDLERSMRELQATH 502
                ND+  ++L+  L  I   KE     +++ D S    ++S++   L++S+   +   
Sbjct: 919  QQMNNDL--EKLTHELEKIGLNKERLLHDEQSTDDSRYKLLESKLESTLKKSLEIKEEKI 976

Query: 503  AETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQ 542
            A     LE++ N        N+  + E++ V +  E L+Q
Sbjct: 977  AALEARLEESTN-------YNQQLRQELKTVKKNYEALKQ 1009



 Score = 73.9 bits (180), Expect = 9e-13
 Identities = 130/638 (20%), Positives = 254/638 (39%), Gaps = 105/638 (16%)

Query: 27   LQETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQ-EDKIKRMATKLIRL 85
            LQ+T      K +Q  S +   E+E++ L+ + E + +     +Q E + K +  +  +L
Sbjct: 768  LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQL 827

Query: 86   VNDKKRYERVGGGPKRLGRDVEMEEM-IEQLQEKVHELEKQNETLKNR------------ 132
              DKK+ E+     KRL +  E+++  +E+   K+  LEK+N+TL               
Sbjct: 828  EKDKKQLEKEN---KRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCVRLK 884

Query: 133  -------------------LISAKQQLQTQGYRQTPYNNVQSRINTGRRKANEN------ 167
                               L++ ++ L ++  +    NN   ++     K   N      
Sbjct: 885  ELEKENKELVKRATIDIKTLVTLREDLVSEKLKTQQMNNDLEKLTHELEKIGLNKERLLH 944

Query: 168  --------------AGLQECPRKGIKFQDADVA--ETPHPMFTKYGNSLLEEARGEIRNL 211
                          + L+   +K ++ ++  +A  E      T Y   L +E +   +N 
Sbjct: 945  DEQSTDDSRYKLLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNY 1004

Query: 212  ENVIQSQRGQIEELEHLAEILK---TQLRRKENEIELSLLQLREQQATDQRSNIRDNVEM 268
            E +   QR   E +   +  +     +  R+  E    LL+++++    +R+N     E 
Sbjct: 1005 EAL--KQRQDEERMVQSSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNATLQAEK 1062

Query: 269  IKLH---KQLVEKSNALSA----MEGKFIQLQEKQRTLRISHDALMANGDELNMQ---LK 318
              L    KQL  ++N L A    ++ + + LQE+  TL+  +  L      LN Q   L 
Sbjct: 1063 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLM 1122

Query: 319  EQR----LKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAH 374
             Q     ++  SLE +  S+      ++ L D +    ++ ELL E     Y+S  S   
Sbjct: 1123 NQNAQLLIQQSSLENENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLIS--K 1180

Query: 375  EEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQ 434
                K   + L+V+   LE      L  K ++ D  K  + + EK++ EN+  +    E 
Sbjct: 1181 HGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLLENKNHETVAAEY 1240

Query: 435  KQQLDELKKRIKLYNQ---ENDI-NADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKD 490
            K+   E  +    Y+Q   E ++   D  +   LL  ++ EQ         ++++E +K 
Sbjct: 1241 KKLCGENDRLNHTYSQLLKETEVLQTDHKNLKSLLNNSKLEQ--------TRLEAEFSK- 1291

Query: 491  LERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQD------- 543
            L+   ++L  T  +   + E    +     + N+    +++ +  +   L +        
Sbjct: 1292 LKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRTLLEQNMESKDL 1351

Query: 544  YELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKF 581
            + ++  QY+  L+    +  KLE ++ D      QYKF
Sbjct: 1352 FHVEQRQYIDKLNELRRQKEKLEEKIMD------QYKF 1383



 Score = 64.3 bits (155), Expect = 7e-10
 Identities = 116/518 (22%), Positives = 224/518 (43%), Gaps = 77/518 (14%)

Query: 107 EMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANE 166
           E+EE  EQL +   ELE+    LK RL      L +       Y   +  ++  R KA  
Sbjct: 266 ELEEKTEQLLDCKQELEQMEIELK-RLQQENMNLLSDARSARMY---RDELDALREKAVR 321

Query: 167 NAGLQ-ECPR-----KGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRG 220
              L+ E  R       I+F  A V E       K  N +L E +  + +     +++  
Sbjct: 322 VDKLESEVSRYKERLHDIEFYKARVEE------LKEDNQVLLETKTMLEDQLEGTRARSD 375

Query: 221 QIEELE----------HLAEILKTQLRRKENEI--ELSLLQLREQQATDQRSNIRDNVEM 268
           ++ ELE          H  E+ +   R+K  E+  E   L++ ++Q+ D+  ++   +E 
Sbjct: 376 KLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQ 435

Query: 269 IKLHKQLVE-------------KSNALSAMEGKFIQLQEKQRTLRISHDALMANGDE-LN 314
           I    +L E              S+ L  +E +   L +    LR + D++  N  + L 
Sbjct: 436 ISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILK 495

Query: 315 MQLKEQRL--KCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSA 372
           M+ + QRL  K   LE ++   K S   ++  Q+   DL KE+  L++  + L +++   
Sbjct: 496 MEKENQRLSKKVEILENEIVQEKQS---LQNCQNLSKDLMKEKAQLEKTIETLRENS--- 549

Query: 373 AHEEQWKLKEQQ---LKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQL 429
             E Q K+ EQ+   L   ++ L    +S ++ +  + D  K  +  +E + + + +L  
Sbjct: 550 --ERQIKILEQENEHLNQTVSSLRQ--RSQISAEARVKDIEKENKILHESIKETSSKLSK 605

Query: 430 QYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINK 489
              E++Q    +KK ++ Y ++ +  A+EL   L  ++ + E     ++ L K+  E  +
Sbjct: 606 IEFEKRQ----IKKELEHYKEKGE-RAEELENELHHLEKENELLQKKITNL-KITCEKIE 659

Query: 490 DLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYE-LKV 548
            LE+   EL+  + +  + L+  +N+      + K             EN Q D E L++
Sbjct: 660 ALEQENSELERENRKLKKTLDSFKNLTFQLESLEK-------------ENSQLDEENLEL 706

Query: 549 EQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIM 586
            + V  L   + ++ +L+ + K++    +Q K   E++
Sbjct: 707 RRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL 744



 Score = 33.5 bits (75), Expect = 1.3
 Identities = 30/139 (21%), Positives = 74/139 (53%), Gaps = 4/139 (2%)

Query: 419 KLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLS 478
           +L QE  E   Q L+ KQ+L++++  +K   QEN +N    + +  + + + +       
Sbjct: 262 RLRQELEEKTEQLLDCKQELEQMEIELKRLQQEN-MNLLSDARSARMYRDELDALREKAV 320

Query: 479 FLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKME 538
            + K++SE+++  ER + +++   A  V+EL++   +L+    + +D      A + K+ 
Sbjct: 321 RVDKLESEVSRYKER-LHDIEFYKAR-VEELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378

Query: 539 NLQQDYELKVEQYVHLLDI 557
            L+++  L+++  +H +++
Sbjct: 379 ELEKE-NLQLKAKLHDMEM 396


>gi|208022632 coiled-coil domain containing 88A isoform 1 [Homo
           sapiens]
          Length = 1870

 Score = 86.3 bits (212), Expect = 2e-16
 Identities = 130/588 (22%), Positives = 261/588 (44%), Gaps = 84/588 (14%)

Query: 48  EELEDRFLRLHDENILLKQHARKQE------DKIKRMATKLIRLVNDKKRY-------ER 94
           E++E    RL  EN+ L   AR         D ++  A ++ +L ++  RY       E 
Sbjct: 282 EQMEIELKRLQQENMNLLSDARSARMYRDELDALREKAVRVDKLESEVSRYKERLHDIEF 341

Query: 95  VGGGPKRLGRD----VEMEEMIE-QLQ------EKVHELEKQNETLKNRLISAK------ 137
                + L  D    +E + M+E QL+      +K+HELEK+N  LK +L   +      
Sbjct: 342 YKARVEELKEDNQVLLETKTMLEDQLEGTRARSDKLHELEKENLQLKAKLHDMEMERDMD 401

Query: 138 --------QQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETP 189
                   ++  T    Q    +    +     + +  + L E P+K +  +  ++  + 
Sbjct: 402 RKKIEELMEENMTLEMAQKQSMDESLHLGWELEQISRTSELSEAPQKSLGHEVNELTSS- 460

Query: 190 HPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEI--ELSL 247
             +  +  N  L +   E+R   + ++    +I ++E   + L  ++   ENEI  E   
Sbjct: 461 RLLKLEMENQSLTKTVEELRTTVDSVEGNASKILKMEKENQRLSKKVEILENEIVQEKQS 520

Query: 248 LQ--------LREQQATDQRS--NIRDNVE-MIKLHKQLVEKSN--ALSAMEGKFIQLQE 294
           LQ        L +++A  +++   +R+N E  IK+ +Q  E  N    S  +   I  + 
Sbjct: 521 LQNCQNLSKDLMKEKAQLEKTIETLRENSERQIKILEQENEHLNQTVSSLRQRSQISAEA 580

Query: 295 KQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKE 354
           + + +   +  L  +  E + +L +   +   ++K+L   K    R EEL++ ++ LEKE
Sbjct: 581 RVKDIEKENKILHESIKETSSKLSKIEFEKRQIKKELEHYKEKGERAEELENELHHLEKE 640

Query: 355 RELLKENYD--KLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKT 412
            ELL++     K+      A  +E  +L+ +  K++                + LD  K 
Sbjct: 641 NELLQKKITNLKITCEKIEALEQENSELERENRKLK----------------KTLDSFKN 684

Query: 413 ERDQNEKLVQENRELQLQYLEQKQQLDELK------KRIKLYNQENDINADELSEALLLI 466
              Q E L +EN +L  + LE ++ ++ LK       +++L N+E +   ++L + L L+
Sbjct: 685 LTFQLESLEKENSQLDEENLELRRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL 744

Query: 467 KAQ-KEQKNGDLSF--LVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKIN 523
           KA  K+ +  ++S+  L   +  + K LE S +++Q   +E +Q+LE     L    +  
Sbjct: 745 KASFKKTERLEVSYQGLDIENQRLQKTLENSNKKIQQLESE-LQDLEMENQTLQKNLEEL 803

Query: 524 KDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKD 571
           K     +E + ++ ++L+Q+   ++E+    L+    R+ + +A++KD
Sbjct: 804 KISSKRLEQLEKENKSLEQETS-QLEKDKKQLEKENKRLRQ-QAEIKD 849



 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 118/523 (22%), Positives = 228/523 (43%), Gaps = 93/523 (17%)

Query: 34   RTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYE 93
            +T+ S +  S++S E    R   +  EN +L        + IK  ++KL ++  +K++ +
Sbjct: 565  QTVSSLRQRSQISAEA---RVKDIEKENKIL-------HESIKETSSKLSKIEFEKRQIK 614

Query: 94   RVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNV 153
                  K L    E  E  E+L+ ++H LEK+NE L+ ++                  N+
Sbjct: 615  ------KELEHYKEKGERAEELENELHHLEKENELLQKKI-----------------TNL 651

Query: 154  QSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLEN 213
            +           EN+ L+   RK  K  D+    T      +  NS L+E   E+R    
Sbjct: 652  KITCEKIEALEQENSELERENRKLKKTLDSFKNLTFQLESLEKENSQLDEENLELRR--- 708

Query: 214  VIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHK 273
                    +E L             K   ++++ LQL  ++   ++  ++  +E++K   
Sbjct: 709  -------NVESL-------------KCASMKMAQLQLENKELESEKEQLKKGLELLKASF 748

Query: 274  QLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHS 333
            +  E+     + +G  I+ Q  Q+TL  S+  +     +L  +L++  ++  +L+K L  
Sbjct: 749  KKTERLEV--SYQGLDIENQRLQKTLENSNKKIQ----QLESELQDLEMENQTLQKNLEE 802

Query: 334  MKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLK---VQIA 390
            +K S +R+E+L+     LE+E   L++  DK      +    +Q ++K+  L+   V+I 
Sbjct: 803  LKISSKRLEQLEKENKSLEQETSQLEK--DKKQLEKENKRLRQQAEIKDTTLEENNVKIG 860

Query: 391  QLE---TALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKL 447
             LE     L  ++    E   RLK    +N++LV +   + ++ L   ++ D + +++K 
Sbjct: 861  NLEKENKTLSKEIGIYKESCVRLKELEKENKELV-KRATIDIKTLVTLRE-DLVSEKLKT 918

Query: 448  YNQENDINADELSEALLLIKAQK------EQKNGDLSFLV--KVDSEINKDLERSMRELQ 499
                ND+  ++L+  L  I   K      EQ   D   L+  K++S + K LE    ++ 
Sbjct: 919  QQMNNDL--EKLTHELEKIGLNKERLLHDEQSTDDRYKLLESKLESTLKKSLEIKEEKIA 976

Query: 500  ATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQ 542
            A  A     LE++ N        N+  + E++ V +  E L+Q
Sbjct: 977  ALEA----RLEESTN-------YNQQLRQELKTVKKNYEALKQ 1008



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 108/502 (21%), Positives = 222/502 (44%), Gaps = 72/502 (14%)

Query: 27   LQETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQH---------ARKQEDKIKR 77
            L E+    T+K    +       LE R     + N  L+Q          A KQ    +R
Sbjct: 955  LLESKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEER 1014

Query: 78   MATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAK 137
            M      +  +  ++ER            E    + ++++++ E+E+ N TL+    + K
Sbjct: 1015 MVQSSPPISGEDNKWER---------ESQETTRELLKVKDRLIEVERNNATLQ----AEK 1061

Query: 138  QQLQTQGYR-QTPYNNVQSRINTGRRKA----NENAGLQECPRKGIKFQDADVAETPHPM 192
            Q L+TQ  + +T  NN+Q++I   +R+      +N  LQ    K ++ +++ +      +
Sbjct: 1062 QALKTQLKQLETQNNNLQAQILALQRQTVSLQEQNTTLQTQNAK-LQVENSTLNSQSTSL 1120

Query: 193  FTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLRE 252
              +    L++++     +LEN  +S   + E+L+ L +     L +   ++EL    L E
Sbjct: 1121 MNQNAQLLIQQS-----SLENENESVIKEREDLKSLYD----SLIKDHEKLEL----LHE 1167

Query: 253  QQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFI----QLQEKQRTLRISHDALMA 308
            +QA++  S I  +  +   HK L  +   L     + +    QL++ ++ L++  + ++ 
Sbjct: 1168 RQASEYESLISKHGTLKSAHKNLEVEHRDLEDRYNQLLKQKGQLEDLEKMLKVEQEKMLL 1227

Query: 309  NGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDS 368
                      E +  C   ++  H+     +  E LQ    D +  + LL  N  KL  +
Sbjct: 1228 ENKNHETVAAEYKKLCGENDRLNHTYSQLLKETEVLQ---TDHKNLKSLL--NNSKLEQT 1282

Query: 369  AFSAAHEEQWKLKEQQLKVQIA--------QLETALKSDLTDKTE-ILDRLKTERDQNEK 419
               A   E  KLKEQ  ++ I         +L + LK +L ++   +LD+++T   QN  
Sbjct: 1283 RLEA---EFSKLKEQYQQLDITSTKLNNQCELLSQLKGNLEEENRHLLDQIQTLMLQNRT 1339

Query: 420  LVQENRELQ-LQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGD-- 476
            L+++N E + L ++EQ+Q +D+L    +L  Q+  +  +++ +          ++ G+  
Sbjct: 1340 LLEQNMESKDLFHVEQRQYIDKLN---ELRRQKEKLE-EKIMDQYKFYDPSPPRRRGNWI 1395

Query: 477  ---LSFLVKVDSEINKDLERSM 495
               +  L+K   +IN++ ++S+
Sbjct: 1396 TLKMRKLIKSKKDINRERQKSL 1417



 Score = 64.3 bits (155), Expect = 7e-10
 Identities = 116/518 (22%), Positives = 224/518 (43%), Gaps = 77/518 (14%)

Query: 107 EMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANE 166
           E+EE  EQL +   ELE+    LK RL      L +       Y   +  ++  R KA  
Sbjct: 266 ELEEKTEQLLDCKQELEQMEIELK-RLQQENMNLLSDARSARMY---RDELDALREKAVR 321

Query: 167 NAGLQ-ECPR-----KGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRG 220
              L+ E  R       I+F  A V E       K  N +L E +  + +     +++  
Sbjct: 322 VDKLESEVSRYKERLHDIEFYKARVEE------LKEDNQVLLETKTMLEDQLEGTRARSD 375

Query: 221 QIEELE----------HLAEILKTQLRRKENEI--ELSLLQLREQQATDQRSNIRDNVEM 268
           ++ ELE          H  E+ +   R+K  E+  E   L++ ++Q+ D+  ++   +E 
Sbjct: 376 KLHELEKENLQLKAKLHDMEMERDMDRKKIEELMEENMTLEMAQKQSMDESLHLGWELEQ 435

Query: 269 IKLHKQLVE-------------KSNALSAMEGKFIQLQEKQRTLRISHDALMANGDE-LN 314
           I    +L E              S+ L  +E +   L +    LR + D++  N  + L 
Sbjct: 436 ISRTSELSEAPQKSLGHEVNELTSSRLLKLEMENQSLTKTVEELRTTVDSVEGNASKILK 495

Query: 315 MQLKEQRL--KCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSA 372
           M+ + QRL  K   LE ++   K S   ++  Q+   DL KE+  L++  + L +++   
Sbjct: 496 MEKENQRLSKKVEILENEIVQEKQS---LQNCQNLSKDLMKEKAQLEKTIETLRENS--- 549

Query: 373 AHEEQWKLKEQQ---LKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQL 429
             E Q K+ EQ+   L   ++ L    +S ++ +  + D  K  +  +E + + + +L  
Sbjct: 550 --ERQIKILEQENEHLNQTVSSLRQ--RSQISAEARVKDIEKENKILHESIKETSSKLSK 605

Query: 430 QYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINK 489
              E++Q    +KK ++ Y ++ +  A+EL   L  ++ + E     ++ L K+  E  +
Sbjct: 606 IEFEKRQ----IKKELEHYKEKGE-RAEELENELHHLEKENELLQKKITNL-KITCEKIE 659

Query: 490 DLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYE-LKV 548
            LE+   EL+  + +  + L+  +N+      + K             EN Q D E L++
Sbjct: 660 ALEQENSELERENRKLKKTLDSFKNLTFQLESLEK-------------ENSQLDEENLEL 706

Query: 549 EQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIM 586
            + V  L   + ++ +L+ + K++    +Q K   E++
Sbjct: 707 RRNVESLKCASMKMAQLQLENKELESEKEQLKKGLELL 744



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 121/602 (20%), Positives = 252/602 (41%), Gaps = 111/602 (18%)

Query: 27   LQETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQ-EDKIKRMATKLIRL 85
            LQ+T      K +Q  S +   E+E++ L+ + E + +     +Q E + K +  +  +L
Sbjct: 768  LQKTLENSNKKIQQLESELQDLEMENQTLQKNLEELKISSKRLEQLEKENKSLEQETSQL 827

Query: 86   VNDKKRYERVGGGPKRLGRDVEMEEM-IEQLQEKVHELEKQNETLKNRLISAKQQLQTQG 144
              DKK+ E+     KRL +  E+++  +E+   K+  LEK+N+TL   +   K+      
Sbjct: 828  EKDKKQLEKEN---KRLRQQAEIKDTTLEENNVKIGNLEKENKTLSKEIGIYKESCV--- 881

Query: 145  YRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEA 204
                            R K  E    +   R  I  +                   L   
Sbjct: 882  ----------------RLKELEKENKELVKRATIDIKT------------------LVTL 907

Query: 205  RGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRD 264
            R ++ + +   Q     +E+L H  E+ K  L ++          L ++Q+TD R  + +
Sbjct: 908  REDLVSEKLKTQQMNNDLEKLTH--ELEKIGLNKER--------LLHDEQSTDDRYKLLE 957

Query: 265  NVEMIKLHKQLVEKSNALSAMEGKF-------IQLQEKQRTLRISHDALMANGDELNM-- 315
            +     L K L  K   ++A+E +         QL+++ +T++ +++AL    DE  M  
Sbjct: 958  SKLESTLKKSLEIKEEKIAALEARLEESTNYNQQLRQELKTVKKNYEALKQRQDEERMVQ 1017

Query: 316  -----QLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLK------ENYDK 364
                   ++ + +  S E     +K  +R IE  ++    L+ E++ LK      E  + 
Sbjct: 1018 SSPPISGEDNKWERESQETTRELLKVKDRLIEVERNNAT-LQAEKQALKTQLKQLETQNN 1076

Query: 365  LYDSAFSAAHEEQWKLKEQ---------QLKVQIAQLETALKSDLTDKTEILDRLKTERD 415
               +   A   +   L+EQ         +L+V+ + L +   S +    ++L +  +  +
Sbjct: 1077 NLQAQILALQRQTVSLQEQNTTLQTQNAKLQVENSTLNSQSTSLMNQNAQLLIQQSSLEN 1136

Query: 416  QNEKLVQENRELQLQY---LEQKQQLDELKKR--------------IKLYNQENDINADE 458
            +NE +++E  +L+  Y   ++  ++L+ L +R              +K  ++  ++   +
Sbjct: 1137 ENESVIKEREDLKSLYDSLIKDHEKLELLHERQASEYESLISKHGTLKSAHKNLEVEHRD 1196

Query: 459  LSEALLLIKAQKEQKNGDLSFLVKVDSE----INKDLERSMRELQATHAETVQELEKTRN 514
            L +    +  QK Q   DL  ++KV+ E     NK+ E    E +    E    L  T +
Sbjct: 1197 LEDRYNQLLKQKGQLE-DLEKMLKVEQEKMLLENKNHETVAAEYKKLCGEN-DRLNHTYS 1254

Query: 515  MLIMQHKINKDYQMEVEAV--TRKMENLQQDYEL-KVEQYVHLLDIRAARIH---KLEAQ 568
             L+ + ++ +     ++++    K+E  + + E  K+++    LDI + +++   +L +Q
Sbjct: 1255 QLLKETEVLQTDHKNLKSLLNNSKLEQTRLEAEFSKLKEQYQQLDITSTKLNNQCELLSQ 1314

Query: 569  LK 570
            LK
Sbjct: 1315 LK 1316



 Score = 33.5 bits (75), Expect = 1.3
 Identities = 30/139 (21%), Positives = 74/139 (53%), Gaps = 4/139 (2%)

Query: 419 KLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLS 478
           +L QE  E   Q L+ KQ+L++++  +K   QEN +N    + +  + + + +       
Sbjct: 262 RLRQELEEKTEQLLDCKQELEQMEIELKRLQQEN-MNLLSDARSARMYRDELDALREKAV 320

Query: 479 FLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKME 538
            + K++SE+++  ER + +++   A  V+EL++   +L+    + +D      A + K+ 
Sbjct: 321 RVDKLESEVSRYKER-LHDIEFYKAR-VEELKEDNQVLLETKTMLEDQLEGTRARSDKLH 378

Query: 539 NLQQDYELKVEQYVHLLDI 557
            L+++  L+++  +H +++
Sbjct: 379 ELEKE-NLQLKAKLHDMEM 396


>gi|148596984 golgi autoantigen, golgin subfamily b, macrogolgin (with
            transmembrane signal), 1 [Homo sapiens]
          Length = 3259

 Score = 85.9 bits (211), Expect = 2e-16
 Identities = 142/657 (21%), Positives = 265/657 (40%), Gaps = 121/657 (18%)

Query: 34   RTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYE 93
            RT+K+ + V   S+++LE     +  EN+      RK+      +A+  + L + +    
Sbjct: 2040 RTVKALEFVQTESQKDLE-----ITKENLAQAVEHRKKAQA--ELASFKVLLDDTQSEAA 2092

Query: 94   RVGGGPKRLGRDVEM--EEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQ-------- 143
            RV     +L ++++   E +  Q+++K  +LE++ E  + + +  K+ +Q +        
Sbjct: 2093 RVLADNLKLKKELQSNKESVKSQMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREK 2152

Query: 144  GYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSL--- 200
             + +     +Q  +N   +K  E   LQE         + D   T    FTK  +SL   
Sbjct: 2153 VHLEETIGEIQVTLN---KKDKEVQQLQE---------NLDSTVTQLAAFTKSMSSLQDD 2200

Query: 201  ----LEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQAT 256
                ++EA+   R   + IQS+  +I   E    +LK QLR+    +E            
Sbjct: 2201 RDRVIDEAKKWERKFSDAIQSKEEEIRLKEDNCSVLKDQLRQMSIHME------------ 2248

Query: 257  DQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQ 316
                 ++ N+  ++  KQ+ E            +QLQ+K        D L     EL  Q
Sbjct: 2249 ----ELKINISRLEHDKQIWESKAQTE------VQLQQK------VCDTLQGENKELLSQ 2292

Query: 317  LKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEE 376
            L+E R    S + +L  +   E  ++ L+D++ DL    E  KE    L           
Sbjct: 2293 LEETRHLYHSSQNELAKL---ESELKSLKDQLTDLSNSLEKCKEQKGNL----------- 2338

Query: 377  QWKLKEQQLKVQIAQLE-TALKSDLTDKTEILDRLKTERDQNEK-----LVQENRELQLQ 430
            +  +++Q+  +Q ++     L++DL    E+  RL  E +  E+     L  +   +Q+ 
Sbjct: 2339 EGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVA 2398

Query: 431  YLEQKQQLD-ELKKRIKLYNQENDIN-------------ADELSEALLLIKAQKEQKNGD 476
              E +QQ D E+K+   L +QE + N              ++L E L  IK +  Q+   
Sbjct: 2399 IAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQ 2458

Query: 477  LSFLVKVDSEINKDLER---SMRELQATHA-------ETVQELEKTRNMLIMQHKINKDY 526
            L   VK  S +  D +R     ++L+  H        + +QE     N L  + +  + +
Sbjct: 2459 LDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSH 2518

Query: 527  QMEVEAVTRKM--------ENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQ 578
              ++ +   K+        E+L Q   +K  Q   LL+++  +  +LE +     Y   +
Sbjct: 2519 MDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENK-----YAKLE 2573

Query: 579  YKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSEVLQASGDKEPVTFCTY 635
             K K     ++ +      +  E+ +   EI   KV+ S    Q +  +E  T   Y
Sbjct: 2574 EKLKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLY 2630



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 123/562 (21%), Positives = 236/562 (41%), Gaps = 61/562 (10%)

Query: 55   LRLHDENI-LLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDV------E 107
            +RL ++N  +LK   R+    ++ +   + RL +DK+ +E       +L + V      E
Sbjct: 2226 IRLKEDNCSVLKDQLRQMSIHMEELKINISRLEHDKQIWESKAQTEVQLQQKVCDTLQGE 2285

Query: 108  MEEMIEQLQEKVHELEK-QNET--LKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKA 164
             +E++ QL+E  H     QNE   L++ L S K QL       T  +N   +    +   
Sbjct: 2286 NKELLSQLEETRHLYHSSQNELAKLESELKSLKDQL-------TDLSNSLEKCKEQKGNL 2338

Query: 165  NENAGLQECPRKGIKFQ----------DADVAETPHPMFTKYGNSLLEEARGEIRNLENV 214
                  QE   +  KF             ++    H         ++    G+   ++  
Sbjct: 2339 EGIIRQQEADIQNSKFSYEQLETDLQASRELTSRLHEEINMKEQKIISLLSGKEEAIQVA 2398

Query: 215  IQSQRGQ----IEELEHLA--EILKTQLRRKENEIELSLL-QLREQQATDQRSNIRDNVE 267
            I   R Q    I+ELE+L   E  +  +  +EN+  +    QL E   T ++ NI+   +
Sbjct: 2399 IAELRQQHDKEIKELENLLSQEEEENIVLEEENKKAVDKTNQLMETLKTIKKENIQQKAQ 2458

Query: 268  MIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSL 327
            +    K +    N    + G + QL+E+  ++ +  D L+      N +LKE+     S 
Sbjct: 2459 LDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEKDQLIQEAAAENNKLKEEIRGLRSH 2518

Query: 328  EKQLHS--MKFSERRIEELQD-----RINDLEKEREL-LKENYDKLYDSAFSAAHEEQWK 379
               L+S   K     I+  +D      I D ++++ L ++   +K  ++ ++   E   K
Sbjct: 2519 MDDLNSENAKLDAELIQYREDLNQVITIKDSQQKQLLEVQLQQNKELENKYAKLEE---K 2575

Query: 380  LKE-QQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLV---QENRELQLQYLEQK 435
            LKE ++    + +   AL+ +  D ++ ++ LK    Q  + V   QE   L L + + K
Sbjct: 2576 LKESEEANEDLRRSFNALQEEKQDLSKEIESLKVSISQLTRQVTALQEEGTLGLYHAQLK 2635

Query: 436  QQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVD-SEINKDLERS 494
             + +E+ +   L++      A EL E L+ ++ +  +K G++   +K +   ++ D    
Sbjct: 2636 VKEEEVHRLSALFSSSQKRIA-ELEEELVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIM 2694

Query: 495  MRELQATH---AETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQY 551
              E +      AE  ++L +    L+M  K NK    ++++  R M +LQ   +   E+ 
Sbjct: 2695 RNETETAEERVAELARDLVEMEQKLLMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEEL 2754

Query: 552  VHLLDIRAARIHKLEAQLKDIA 573
              L         K +A LK++A
Sbjct: 2755 DELK-------RKYDASLKELA 2769



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 134/627 (21%), Positives = 266/627 (42%), Gaps = 94/627 (14%)

Query: 73   DKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHE----------- 121
            ++I     K+I L++ K+   +V     R   D E++E+   L ++  E           
Sbjct: 2375 EEINMKEQKIISLLSGKEEAIQVAIAELRQQHDKEIKELENLLSQEEEENIVLEEENKKA 2434

Query: 122  LEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQ 181
            ++K N+ ++      K+ +Q +    +   ++ S  N   R   +   L+E     I  +
Sbjct: 2435 VDKTNQLMETLKTIKKENIQQKAQLDSFVKSMSSLQNDRDRIVGDYQQLEERHLSIILEK 2494

Query: 182  DADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIE-ELEHLAEILKTQLRRKE 240
            D  + E          N L EE RG +R+  + + S+  +++ EL    E L   +  K+
Sbjct: 2495 DQLIQEA-----AAENNKLKEEIRG-LRSHMDDLNSENAKLDAELIQYREDLNQVITIKD 2548

Query: 241  NEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLR 300
            ++ +  LL+++ QQ  +  +      +  KL ++L E   A   +   F  LQE+++ L 
Sbjct: 2549 SQ-QKQLLEVQLQQNKELEN------KYAKLEEKLKESEEANEDLRRSFNALQEEKQDLS 2601

Query: 301  ISHDALMANGDELNMQ-----------LKEQRLKCCSLEKQLHSMKFS--ERRIEELQDR 347
               ++L  +  +L  Q           L   +LK    E    S  FS  ++RI EL++ 
Sbjct: 2602 KEIESLKVSISQLTRQVTALQEEGTLGLYHAQLKVKEEEVHRLSALFSSSQKRIAELEEE 2661

Query: 348  INDLEKER---------ELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETAL-- 396
            +  ++KE          +L KE     +D+       E  + +  +L   + ++E  L  
Sbjct: 2662 LVCVQKEAAKKVGEIEDKLKKELKHLHHDAGIMRNETETAEERVAELARDLVEMEQKLLM 2721

Query: 397  ----KSDLTDKTEILDR-LKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQE 451
                   LT + +   R + + ++  +   +E  EL+ +Y    ++L +LK++  L N+E
Sbjct: 2722 VTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQ-GLLNRE 2780

Query: 452  NDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEI----------NKDLERSMRELQAT 501
             D     LSE    + + +E     LS L K++ ++          +  LE S  ++Q+ 
Sbjct: 2781 RDAL---LSETAFSMNSTEENS---LSHLEKLNQQLLSKDEQLLHLSSQLEDSYNQVQS- 2833

Query: 502  HAETVQELEKTRNMLIMQ-HKINKDYQ-------------MEVEAVTRKMENLQQDY--- 544
             ++ +  L+  R+ L  +  K  K  +              EV+++ + M +LQ D    
Sbjct: 2834 FSKAMASLQNERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQSLKKAMSSLQNDRDRL 2893

Query: 545  --ELKVEQYVHL-LDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLE 601
              ELK  Q  +L ++     +H L+AQL++    TK ++   E +  +++    E   L 
Sbjct: 2894 LKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELRQENLSWQHELHQLR 2953

Query: 602  RGENLFEIHINKVTFSSEVLQASGDKE 628
              ++ +EIH  ++    + L A  DK+
Sbjct: 2954 MEKSSWEIHERRM--KEQYLMAISDKD 2978



 Score = 66.2 bits (160), Expect = 2e-10
 Identities = 120/573 (20%), Positives = 227/573 (39%), Gaps = 78/573 (13%)

Query: 27   LQETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKR-MATKLIRL 85
            LQE    + M+  +   R   +  + + L L +EN  L+       D  K  M T L   
Sbjct: 1664 LQEAE--QEMEEMKEKMRKFAKSKQQKILELEEENDRLRAEVHPAGDTAKECMETLLSSN 1721

Query: 86   VNDKKRYERVGGGPKRLGRDV-----EMEEMIEQLQEKVHELEKQNETLKNRLISAKQQL 140
             + K+  ERV    + L +       E + + E++Q+  H++E       N   + K   
Sbjct: 1722 ASMKEELERVKMEYETLSKKFQSLMSEKDSLSEEVQDLKHQIEGNVSKQANLEATEKHDN 1781

Query: 141  QT----QGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKY 196
            QT    +G +  P          G  +  ++  +   P      +    A++ +P  +K 
Sbjct: 1782 QTNVTEEGTQSIP----------GETEEQDSLSMSTRPTCS---ESVPSAKSANPAVSKD 1828

Query: 197  GNS---------LLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEI---- 243
             +S          +++ +  I  LE   Q  +   + LE+    L +Q+  K+ E+    
Sbjct: 1829 FSSHDEINNYLQQIDQLKERIAGLEEEKQKNKEFSQTLENEKNTLLSQISTKDGELKMLQ 1888

Query: 244  -ELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKS--NALSAMEGKFIQLQEKQRTLR 300
             E++ + L  QQ  ++ S +    E  +  K  +E+   N L+ + G      +     +
Sbjct: 1889 EEVTKMNLLNQQIQEELSRVTKLKETAEEEKDDLEERLMNQLAELNGSIGNYCQDVTDAQ 1948

Query: 301  ISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKE 360
            I ++ L +    L         KC S  ++       E+   E + R   LEK +   KE
Sbjct: 1949 IKNELLESEMKNLK--------KCVSELEEEKQQLVKEKTKVESEIRKEYLEKIQGAQKE 2000

Query: 361  NYDKLYDSAFSAAHEEQWKLKEQQLKVQ------------IAQLETALKSDLTDKTEILD 408
              +K      S A E Q  LKE+Q +V+            I+ LE  +K+    +TE   
Sbjct: 2001 PGNK------SHAKELQELLKEKQQEVKQLQKDCIRYQEKISALERTVKALEFVQTESQK 2054

Query: 409  RLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKA 468
             L+  ++   + V+  ++ Q +    K  LD+ +        +N     EL      +K+
Sbjct: 2055 DLEITKENLAQAVEHRKKAQAELASFKVLLDDTQSEAARVLADNLKLKKELQSNKESVKS 2114

Query: 469  QKEQKNGDLSFLVKVDSEINKDLERSMRE-LQATHAETVQELEKTRNMLIMQHKINKDYQ 527
            Q +QK+ DL   ++   E +   +++M+E L A   E V   E    + +  +K +K+ Q
Sbjct: 2115 QMKQKDEDLERRLEQAEEKHLKEKKNMQEKLDALRREKVHLEETIGEIQVTLNKKDKEVQ 2174

Query: 528  M----------EVEAVTRKMENLQQDYELKVEQ 550
                       ++ A T+ M +LQ D +  +++
Sbjct: 2175 QLQENLDSTVTQLAAFTKSMSSLQDDRDRVIDE 2207



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 121/527 (22%), Positives = 221/527 (41%), Gaps = 81/527 (15%)

Query: 106 VEMEEMIEQ----LQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGR 161
           VE++++I Q    LQ+K   L+++ +   N++   K   +    + T  N     +    
Sbjct: 62  VELKDIIRQKDVQLQQKDEALQEERKAADNKIKKLKLHAKA---KLTSLNKYIEEM---- 114

Query: 162 RKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLE-NVIQSQRG 220
            KA     L   P+   +    D + T   M  +     L+E    I  L+  + Q+Q  
Sbjct: 115 -KAQGGTVLPTEPQSEEQLSKHDKSSTEEEMEIEKIKHKLQEKEELISTLQAQLTQAQAE 173

Query: 221 Q----IEELEHLAEILKTQLRRKE---NEIELSLLQLREQQATDQRSNIRDN--VEMIKL 271
           Q      E+E    ++K QL+ KE   + ++  L Q + +QA  Q    +D      ++L
Sbjct: 174 QPAQSSTEMEEFV-MMKQQLQEKEEFISTLQAQLSQTQAEQAAQQVVREKDARFETQVRL 232

Query: 272 HK----QLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSL 327
           H+    QLV +++  + M+ K   L+  QR L    ++L+     ++  L +Q L     
Sbjct: 233 HEDELLQLVTQADVETEMQQK---LRVLQRKLEEHEESLVGRAQVVD--LLQQELTAAEQ 287

Query: 328 EKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLY------DSAFSAAHEEQWKLK 381
             Q+ S +  +   E    R N +E ERE  K   +K+         +F    EE   L 
Sbjct: 288 RNQILSQQLQQMEAEHNTLR-NTVETEREESKILLEKMELEVAERKLSFHNLQEEMHHLL 346

Query: 382 EQ---------QLKVQIAQLETALKSDLTDKTE-ILDRLKTE----------RDQNEKLV 421
           EQ         +L+ + + LE   K+++ +KT  IL   KT           +DQN KL+
Sbjct: 347 EQFEQAGQAQAELESRYSALEQKHKAEMEEKTSHILSLQKTGQELQSACDALKDQNSKLL 406

Query: 422 QENRELQLQYLEQKQQL-DELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFL 480
           Q+  E  +Q  +  QQL D+L+++ K           E+S+ L  +  Q+ +     SF 
Sbjct: 407 QDKNEQAVQSAQTIQQLEDQLQQKSK-----------EISQFLNRLPLQQHETASQTSF- 454

Query: 481 VKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKM--- 537
                  N+  +    E  A+  + V ELE  +  L++     ++ + E E ++ ++   
Sbjct: 455 ---PDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIELEELKAENEKLSSQITLL 511

Query: 538 --ENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFK 582
             +N   + + +V + + ++DI   R    E   +D+   T   K K
Sbjct: 512 EAQNRTGEADREVSE-ISIVDIANKRSSSAEESGQDVLENTFSQKHK 557



 Score = 61.6 bits (148), Expect = 4e-09
 Identities = 89/391 (22%), Positives = 171/391 (43%), Gaps = 45/391 (11%)

Query: 198  NSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILK-----TQLRRKENEIELSLLQLRE 252
            N L+EE +   +N +N   +     EE + L   +K     T+LR +  ++E++L +   
Sbjct: 722  NQLIEEFK---KNADNNSSAFTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAER 778

Query: 253  QQATDQRSNI-RDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGD 311
            Q+  D  S    DN+        L E+ ++LS        ++ K + ++I  + L    D
Sbjct: 779  QRRLDYESQTAHDNL--------LTEQIHSLS--------IEAKSKDVKI--EVLQNELD 820

Query: 312  ELNMQLKEQRLKCCSLEKQLHSMKFSE-----RRIEELQDRINDL-----EKERELLKEN 361
            ++ +Q  EQ     SL+ QL + K SE      R+  +  ++ +L     +KE E+ K +
Sbjct: 821  DVQLQFSEQSTLIRSLQSQLQN-KESEVLEGAERVRHISSKVEELSQALSQKELEITKMD 879

Query: 362  YDKLYDSAFSAAHEEQWKLKEQQL-KVQIAQLETALKSDLTDKTEILDRLKTERDQNEKL 420
               L         ++  + K+QQ+ ++  +  E  ++ +  +K  +   +KT ++Q   L
Sbjct: 880  QLLLEKKRDVETLQQTIEEKDQQVTEISFSMTEKMVQLN-EEKFSLGVEIKTLKEQLNLL 938

Query: 421  VQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFL 480
             +     + Q  E  +    LK+     +    I+ +EL     L+K + EQ+   L   
Sbjct: 939  SRAEEAKKEQVEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAA 998

Query: 481  VKVDSEINKDLERSMRELQATHAETVQE--LEKTRNMLIMQHKINKDYQMEVEAVTRKME 538
            +    E+ + + R   EL     E+ +E  L +T    + + K NK+Y    + VT K +
Sbjct: 999  LINRKELLQRVSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEY--SEKCVTSKCQ 1056

Query: 539  NLQQDYELKV-EQYVHLLDIRAARIHKLEAQ 568
             ++   +  + E+ V L  IR     KL A+
Sbjct: 1057 EIEIYLKQTISEKEVELQHIRKDLEEKLAAE 1087



 Score = 61.2 bits (147), Expect = 6e-09
 Identities = 104/525 (19%), Positives = 215/525 (40%), Gaps = 81/525 (15%)

Query: 37   KSRQAVSRVSREELEDR---FLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYE 93
            K ++ + +  +E L  R     +  ++   L++  ++Q+D   R+  +        K  E
Sbjct: 1171 KEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDE---QSKENE 1227

Query: 94   RVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNET--LKNRLISAKQQLQTQGYRQT--- 148
             +G   ++L   +++ E I+       + E  + T  L+  L  A +Q  TQ   ++   
Sbjct: 1228 NIGDQLRQL--QIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLC 1285

Query: 149  ----PYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEA 204
                 ++   S +  G   A   A L+E   + ++ +   V+ T          S L + 
Sbjct: 1286 PDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELE-LKVSST---------TSELTKK 1335

Query: 205  RGEIRNLENVIQSQRGQIEELE---HLAEILKTQLRRKENEIELSLLQLREQQATDQRSN 261
              E+  L+  I  Q  +IE L+   H AE+    L++K    +L +  L   +    + +
Sbjct: 1336 SEEVFQLQEQINKQGLEIESLKTVSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLD 1395

Query: 262  IRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQR 321
                    +L K + +K   +S + G   QL EK+  L            ++  ++ EQ 
Sbjct: 1396 --------ELQKLISKKEEDVSYLSG---QLSEKEAALT-----------KIQTEIIEQE 1433

Query: 322  LKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLK 381
                 L K LH+    E + +E  +RI  L+ E   +K+  +++          E+ + K
Sbjct: 1434 ----DLIKALHTQL--EMQAKEHDERIKQLQVELCEMKQKPEEI---------GEESRAK 1478

Query: 382  EQ-QLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDE 440
            +Q Q K+Q A +    K  L +   + + L   R   E+L +   +++ Q   Q ++ D 
Sbjct: 1479 QQIQRKLQAALISR--KEALKENKSLQEELSLARGTIERLTKSLADVESQVSAQNKEKDT 1536

Query: 441  LKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQA 500
            +  R+ L  +E D    E+  +LL    + +  +     L      + +D E+ ++E+++
Sbjct: 1537 VLGRLALLQEERDKLITEMDRSLL----ENQSLSSSCESLKLALEGLTEDKEKLVKEIES 1592

Query: 501  THAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYE 545
              +  + E  + +         +K+ Q E E + +  EN+  + E
Sbjct: 1593 LKSSKIAESTEWQEK-------HKELQKEYEILLQSYENVSNEAE 1630



 Score = 58.9 bits (141), Expect = 3e-08
 Identities = 135/626 (21%), Positives = 268/626 (42%), Gaps = 94/626 (15%)

Query: 48  EELEDRFLRLHDENILLKQHARKQ-----------EDKIKRMATKLIRLVNDKKRYERVG 96
           +EL+     L D+N  L Q   +Q           ED++++ + ++ + +N     +   
Sbjct: 389 QELQSACDALKDQNSKLLQDKNEQAVQSAQTIQQLEDQLQQKSKEISQFLNRLPLQQHET 448

Query: 97  GGPKRL------GRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYR---Q 147
                       G     EE I  LQ++V ELE +   L    I   ++L+ +  +   Q
Sbjct: 449 ASQTSFPDVYNEGTQAVTEENIASLQKRVVELENEKGALLLSSIEL-EELKAENEKLSSQ 507

Query: 148 TPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDA--DVAETPHPMFTKYGNSLL---E 202
                 Q+R     R+ +E + +    ++    +++  DV E       K  + LL   +
Sbjct: 508 ITLLEAQNRTGEADREVSEISIVDIANKRSSSAEESGQDVLENTFSQKHKELSVLLLEMK 567

Query: 203 EARGEIRNLENVIQSQRGQIEELEHLAEIL-KTQLRRKENE----IELSLLQLREQQATD 257
           EA+ EI  L+  +Q +R   EE +H  E+L + ++++ E E    I++ +      Q   
Sbjct: 568 EAQEEIAFLKLQLQGKRA--EEADH--EVLDQKEMKQMEGEGIAPIKMKVFLEDTGQDFP 623

Query: 258 QRSNIRDNVEMIKLHKQLVEKSNALS---AMEGKFIQL----QEKQRTLRISHDALMANG 310
              N   ++  ++  +   E  +  S   ++    ++L    Q+  ++L    D    + 
Sbjct: 624 LMPNEESSLPAVEKEQASTEHQSRTSEEISLNDAGVELKSTKQDGDKSLSAVPDIGQCHQ 683

Query: 311 DELNMQLKEQRLKCCSLEKQLH-SMKFSERRIEELQDRINDLEKERELLKENYDKLYDSA 369
           DEL  +LK Q L+   LE   H + +  E+ ++E    I++L +  E  K+N D    SA
Sbjct: 684 DELE-RLKSQILE---LELNFHKAQEIYEKNLDEKAKEISNLNQLIEEFKKNADN-NSSA 738

Query: 370 FSAAHEEQWKLKEQ---------------QLKVQIAQLETALKSDLTDKTEILDRLKTER 414
           F+A  EE+ +L  Q               QL++ +A+ E   + D   +T   D L TE+
Sbjct: 739 FTALSEERDQLLSQVKELSMVTELRAQVKQLEMNLAEAERQRRLDYESQT-AHDNLLTEQ 797

Query: 415 DQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKN 474
             +  +  ++++++++ L+   +LD+++           +   E S  +  +++Q + K 
Sbjct: 798 IHSLSIEAKSKDVKIEVLQ--NELDDVQ-----------LQFSEQSTLIRSLQSQLQNKE 844

Query: 475 GDLSFLVKVDSEINKDLER-----SMRELQATHAETVQELEKTRNMLIMQHKINKDYQME 529
            ++    +    I+  +E      S +EL+ T  + +  LEK R++  +Q  I +  Q  
Sbjct: 845 SEVLEGAERVRHISSKVEELSQALSQKELEITKMDQLL-LEKKRDVETLQQTIEEKDQQV 903

Query: 530 VE---AVTRKMENLQQD-YELKVE-----QYVHLLDIRAARIHKLEAQL-KDIAYGTKQY 579
            E   ++T KM  L ++ + L VE     + ++LL  RA    K + +   +++ G KQ 
Sbjct: 904 TEISFSMTEKMVQLNEEKFSLGVEIKTLKEQLNLLS-RAEEAKKEQVEEDNEVSSGLKQN 962

Query: 580 KFKPEIMPDDSVDEFDETIHLERGEN 605
             +       S +E      L + EN
Sbjct: 963 YDEMSPAGQISKEELQHEFDLLKKEN 988



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 108/533 (20%), Positives = 231/533 (43%), Gaps = 72/533 (13%)

Query: 108  MEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQ-TPYNNVQSRINTGRRKANE 166
            +E+  EQLQ+K+ E     + +  +    ++ L+ +  +Q   YN +Q + +  + K NE
Sbjct: 1169 LEKEKEQLQKKLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDE-QSKENE 1227

Query: 167  NAG-----LQECPRKGI--KFQDADVAE----TP---HPMF----TKYGNSLLEEARGEI 208
            N G     LQ   R+ I  K    D  E    TP    P+F      +   +LE      
Sbjct: 1228 NIGDQLRQLQIQVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLES----- 1282

Query: 209  RNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEM 268
             NL     S       L+    + + + + KE E E   L+L+    T + +  + + E+
Sbjct: 1283 -NLCPDWPSHSEDASALQGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELT--KKSEEV 1339

Query: 269  IKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLE 328
             +L +Q+ ++   + +++              +SH+A   + + L  +L+  +L+   LE
Sbjct: 1340 FQLQEQINKQGLEIESLK-------------TVSHEA-EVHAESLQQKLESSQLQIAGLE 1385

Query: 329  KQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFS------AAHEEQWKLKE 382
                 ++  + +++ELQ  I+  E++   L     +  ++A +         E+  K   
Sbjct: 1386 ----HLRELQPKLDELQKLISKKEEDVSYLSGQLSE-KEAALTKIQTEIIEQEDLIKALH 1440

Query: 383  QQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDE-- 440
             QL++Q  + +  +K    +  E+  + +   +++    Q  R+LQ   + +K+ L E  
Sbjct: 1441 TQLEMQAKEHDERIKQLQVELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENK 1500

Query: 441  -LKKRIKLYNQENDINADELSEALLLIKAQKEQKN---GDLSFLVKVDSEINKDLERSMR 496
             L++ + L     +     L++    + AQ ++K+   G L+ L +   ++  +++RS+ 
Sbjct: 1501 SLQEELSLARGTIERLTKSLADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLL 1560

Query: 497  ELQATHAE------TVQELEKTRNMLIMQHKINKDYQM-EVEAVTRKMENLQQDYELKVE 549
            E Q+  +        ++ L + +  L+ + +  K  ++ E      K + LQ++YE+ ++
Sbjct: 1561 ENQSLSSSCESLKLALEGLTEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQ 1620

Query: 550  QYVHLLDIRAARIHKLEA--QLKDIAYG----TKQYKFKPEIMPDDSVDEFDE 596
             Y ++ +      H +EA  Q K   YG    T+  K + E    ++  E +E
Sbjct: 1621 SYENVSNEAERIQHVVEAVRQEKQELYGKLRSTEANKKETEKQLQEAEQEMEE 1673



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 85/431 (19%), Positives = 181/431 (41%), Gaps = 55/431 (12%)

Query: 112  IEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQ 171
            IE L+   HE E   E+L+ +L S+  QLQ  G            +   + K +E   L 
Sbjct: 1353 IESLKTVSHEAEVHAESLQQKLESS--QLQIAGLEH---------LRELQPKLDELQKLI 1401

Query: 172  ECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEI 231
                + + +    ++E    + TK    ++E+    I+ L   ++ Q  + +E     ++
Sbjct: 1402 SKKEEDVSYLSGQLSEKEAAL-TKIQTEIIEQ-EDLIKALHTQLEMQAKEHDERIKQLQV 1459

Query: 232  LKTQLRRKENEI------------ELSLLQLREQQATDQRSNIRDNVEMIK-----LHKQ 274
               ++++K  EI            +L    +  ++A  +  ++++ + + +     L K 
Sbjct: 1460 ELCEMKQKPEEIGEESRAKQQIQRKLQAALISRKEALKENKSLQEELSLARGTIERLTKS 1519

Query: 275  LVEKSNALSAME-------GKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSL 327
            L +  + +SA         G+   LQE++  L    D  +     L+   +  +L    L
Sbjct: 1520 LADVESQVSAQNKEKDTVLGRLALLQEERDKLITEMDRSLLENQSLSSSCESLKLALEGL 1579

Query: 328  E-------KQLHSMKFSE-RRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWK 379
                    K++ S+K S+     E Q++  +L+KE E+L ++Y+ + + A    H  +  
Sbjct: 1580 TEDKEKLVKEIESLKSSKIAESTEWQEKHKELQKEYEILLQSYENVSNEAERIQHVVEAV 1639

Query: 380  LKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLD 439
             +E+Q      +L   L+S   +K E   +L+    + E++ ++ R+      ++  +L+
Sbjct: 1640 RQEKQ------ELYGKLRSTEANKKETEKQLQEAEQEMEEMKEKMRKFAKSKQQKILELE 1693

Query: 440  ELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQ 499
            E   R++         A E  E LL   A  +++       VK++ E      +S+   +
Sbjct: 1694 EENDRLRAEVHPAGDTAKECMETLLSSNASMKEE----LERVKMEYETLSKKFQSLMSEK 1749

Query: 500  ATHAETVQELE 510
             + +E VQ+L+
Sbjct: 1750 DSLSEEVQDLK 1760



 Score = 54.7 bits (130), Expect = 5e-07
 Identities = 86/450 (19%), Positives = 193/450 (42%), Gaps = 49/450 (10%)

Query: 75   IKRMATKLIRLVNDKKRYERVGGGPKRLGRDVE-MEEMIEQLQEKVHELEKQNETLKNRL 133
            +++ A K +  + DK + E      K L  D   M    E  +E+V EL +    ++ +L
Sbjct: 2665 VQKEAAKKVGEIEDKLKKEL-----KHLHHDAGIMRNETETAEERVAELARDLVEMEQKL 2719

Query: 134  ISAKQQLQTQGYRQTPYNNVQSRINTGRRKANE---------NAGLQECPR---KGI--K 179
            +   ++ +    +   +    S +   R  ANE         +A L+E  +   +G+  +
Sbjct: 2720 LMVTKENKGLTAQIQSFGRSMSSLQNSRDHANEELDELKRKYDASLKELAQLKEQGLLNR 2779

Query: 180  FQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRK 239
             +DA ++ET   M +   NSL         +LE + Q    + E+L HL+    +QL   
Sbjct: 2780 ERDALLSETAFSMNSTEENSL--------SHLEKLNQQLLSKDEQLLHLS----SQLEDS 2827

Query: 240  ENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTL 299
             N+++     +   Q  ++R ++ + +E  +  ++  ++S A  +     +Q      +L
Sbjct: 2828 YNQVQSFSKAMASLQ--NERDHLWNELEKFRKSEEGKQRSAAQPSTSPAEVQ------SL 2879

Query: 300  RISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLE-KERELL 358
            + +  +L  + D L  +LK  + +   + +++  +   + +++E QD+    +  + EL 
Sbjct: 2880 KKAMSSLQNDRDRLLKELKNLQQQYLQINQEITELHPLKAQLQEYQDKTKAFQIMQEELR 2939

Query: 359  KENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNE 418
            +EN    ++       +  W++ E+++K Q     +     L+    ++  L++   Q +
Sbjct: 2940 QENLSWQHELHQLRMEKSSWEIHERRMKEQYLMAISDKDQQLSHLQNLIRELRSSSSQTQ 2999

Query: 419  KL-VQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDL 477
             L VQ  R+   +          L    +L   + + +  E+ +  L I    +Q N + 
Sbjct: 3000 PLKVQYQRQASPETSASPDGSQNLVYETELLRTQLNDSLKEIHQKELRI----QQLNSNF 3055

Query: 478  SFLVKVDSEIN---KDLERSMRELQATHAE 504
            S L++  + ++    D  +S+RE Q  + +
Sbjct: 3056 SQLLEEKNTLSIQLCDTSQSLRENQQHYGD 3085



 Score = 51.6 bits (122), Expect = 5e-06
 Identities = 119/629 (18%), Positives = 248/629 (39%), Gaps = 113/629 (17%)

Query: 29   ETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVND 88
            ET      +  Q V+ +S   + ++ ++L++E   L    +  ++++  ++         
Sbjct: 890  ETLQQTIEEKDQQVTEISFS-MTEKMVQLNEEKFSLGVEIKTLKEQLNLLSRAEEAKKEQ 948

Query: 89   KKRYERVGGGPKRLGRDVEMEEMI--EQLQEKVHELEKQNETLKNR----LISAKQQLQT 142
             +    V  G K+   ++     I  E+LQ +   L+K+NE  K +    LI+ K+ LQ 
Sbjct: 949  VEEDNEVSSGLKQNYDEMSPAGQISKEELQHEFDLLKKENEQRKRKLQAALINRKELLQR 1008

Query: 143  QGYRQTPYNNVQSR-------INTGRRKANENAGLQECPRKGI--KFQDADVAETPHPMF 193
                +    N++           T R +  E+   +E   K +  K Q+ ++        
Sbjct: 1009 VSRLEEELANLKDESKKEIPLSETERGEVEEDKENKEYSEKCVTSKCQEIEI-------- 1060

Query: 194  TKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQ 253
              Y    + E   E++++   ++ +    E+ + L + +   L+ K N+I+L   ++ E 
Sbjct: 1061 --YLKQTISEKEVELQHIRKDLEEKLAAEEQFQALVKQMNQTLQDKTNQIDLLQAEISEN 1118

Query: 254  QATDQR-------SNIRDNVEMIK----------------------------LHKQLVEK 278
            QA  Q+       ++  D+V ++K                              K+ ++K
Sbjct: 1119 QAIIQKLITSNTDASDGDSVALVKETVVISPPCTGSSEHWKPELEEKILALEKEKEQLQK 1178

Query: 279  --SNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKF 336
                AL++ +    + QEK+R LR        + + L  Q  EQ  +  ++  QL  ++ 
Sbjct: 1179 KLQEALTSRKAILKKAQEKERHLREELKQQKDDYNRLQEQFDEQSKENENIGDQLRQLQI 1238

Query: 337  SERR--------------------IEELQDRINDLEKERELLKENYDKLYDSAFSAAHEE 376
              R                     +EE   +  +    + +L+ N    + S    A   
Sbjct: 1239 QVRESIDGKLPSTDQQESCSSTPGLEEPLFKATEQHHTQPVLESNLCPDWPSHSEDASAL 1298

Query: 377  QWKLKEQQLKVQIAQLE----------TALKSDLTDKTEILDRLKTERD------QNEKL 420
            Q      Q+K Q+ ++E          ++  S+LT K+E + +L+ + +      ++ K 
Sbjct: 1299 QGGTSVAQIKAQLKEIEAEKVELELKVSSTTSELTKKSEEVFQLQEQINKQGLEIESLKT 1358

Query: 421  VQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFL 480
            V    E+  + L+QK +  +L+     + +E     DEL + +        +K  D+S+L
Sbjct: 1359 VSHEAEVHAESLQQKLESSQLQIAGLEHLRELQPKLDELQKLI-------SKKEEDVSYL 1411

Query: 481  VKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKD--YQMEVEAVTRKME 538
                SE     E ++ ++Q    E    ++     L MQ K + +   Q++VE    K +
Sbjct: 1412 SGQLSE----KEAALTKIQTEIIEQEDLIKALHTQLEMQAKEHDERIKQLQVELCEMKQK 1467

Query: 539  NLQQDYELKVEQYVHLLDIRAARIHKLEA 567
              +   E + +Q +    ++AA I + EA
Sbjct: 1468 PEEIGEESRAKQQIQ-RKLQAALISRKEA 1495


>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
           sapiens]
          Length = 436

 Score = 85.1 bits (209), Expect = 4e-16
 Identities = 85/443 (19%), Positives = 197/443 (44%), Gaps = 24/443 (5%)

Query: 44  RVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKL----IRLVNDKKRYERVGGGP 99
           R++ EEL+++   L +E  L++    + +  IK +  KL    I L  + +  E+ G   
Sbjct: 3   RITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVR 62

Query: 100 KRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINT 159
           ++ G+  E E  + + + +V E E Q    + ++   + Q++ Q   +      + ++  
Sbjct: 63  EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ---EGQVREQEGQVRE 119

Query: 160 GRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQR 219
              +  E  G        ++ Q+  V E    +  + G   + E  G++R  E  ++ Q 
Sbjct: 120 QEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ--VREQEGQVREQEGQVREQE 177

Query: 220 GQIEELEHLAEILKTQLRRKENEI---------ELSLLQLREQQATDQRSNIRDNVEMIK 270
           GQ+ E E      + Q+  +E ++         +   +Q +E+Q  +Q   +R   E + 
Sbjct: 178 GQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMG 237

Query: 271 LHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQ 330
             ++ V+K       + + ++ QE+Q       +  M   +E  ++ KEQ  +     +Q
Sbjct: 238 EQEEQVQKQEEQVQKQEEQMRKQEEQMR---EQEEQMREQEEQMLKQKEQTEQEEQTGEQ 294

Query: 331 LHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLK--VQ 388
              M+  E ++ E ++++ + E++    +E   K  +  +    E+ W+ KEQ  K   Q
Sbjct: 295 EEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWE-QKEQMWEQKEQMWKQEEQ 353

Query: 389 IAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLY 448
           + + E  ++       +  ++++ + +Q  K  ++ R+ + Q  EQK+Q+ E K++++  
Sbjct: 354 MGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQ 413

Query: 449 NQENDINADELSEALLLIKAQKE 471
            ++     +++ +    +  QKE
Sbjct: 414 EEQMGEQKEQMRKQEEHMGEQKE 436



 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 74/417 (17%), Positives = 191/417 (45%), Gaps = 22/417 (5%)

Query: 104 RDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNV---QSRINTG 160
           ++ E++E ++ ++ +  E++   + LK +L + K  L  +G  +     V   + ++   
Sbjct: 12  KNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQVREQ 71

Query: 161 RRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRG 220
             +  E  G        ++ Q+  V E    +  + G   + E  G++R  E  ++ Q G
Sbjct: 72  EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ--VREQEGQVREQEGQVREQEG 129

Query: 221 QIEELEHLAEILKTQLRRKENEIELSLLQLREQ--QATDQRSNIRDNVEMIKLHK-QLVE 277
           Q+ E E      + Q+R +E ++     Q+REQ  Q  +Q   +R+    ++  + Q+ E
Sbjct: 130 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 189

Query: 278 KSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFS 337
           +   +   EG   Q+ E++  +    + +    +++  Q ++ R +   + +Q   ++  
Sbjct: 190 QEGQMGEQEG---QMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQ 246

Query: 338 ERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQ-QLKVQIAQLETAL 396
           E ++++ +++   + K+ E ++E  +++ +       E+  K KEQ + + Q  + E  +
Sbjct: 247 EEQVQKQEEQ---MRKQEEQMREQEEQMREQ-----EEQMLKQKEQTEQEEQTGEQEEQM 298

Query: 397 KSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINA 456
           +       E  ++++ + +Q  +  ++  + + Q  EQK+Q+ E K+++    ++     
Sbjct: 299 REQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQE 358

Query: 457 DELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLER--SMRELQATHAETVQELEK 511
           +++ +    ++ Q+EQ       + K + ++ K  E+    +E      E ++E E+
Sbjct: 359 EQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEE 415



 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 78/415 (18%), Positives = 186/415 (44%), Gaps = 31/415 (7%)

Query: 107 EMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANE 166
           E++E   +LQE++  +E +   ++  +   K++L+T          V+ +    R +  +
Sbjct: 8   ELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQEGQ 67

Query: 167 NAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELE 226
                      ++ Q+  V E    +  + G   + E  G++R  E  ++ Q GQ+ E E
Sbjct: 68  -----------VREQEGQVREQEGQVREQEGQ--VREQEGQVREQEGQVREQEGQVREQE 114

Query: 227 HLAEILKTQLRRKENEIELSLLQLREQ--QATDQRSNIRDNVEMIKLHK-QLVEKSNALS 283
                 + Q+R +E ++     Q+REQ  Q  +Q   +R+    ++  + Q+ E+   + 
Sbjct: 115 GQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVR 174

Query: 284 AMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEE 343
             EG   Q++E++  +R     +     ++  Q ++   +   ++KQ   M   E ++ +
Sbjct: 175 EQEG---QVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRK 231

Query: 344 LQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDK 403
            ++++ + E++ +  +E   K          EEQ + +E+Q++ Q  Q+    +  L  K
Sbjct: 232 QEEQMGEQEEQVQKQEEQVQK---------QEEQMRKQEEQMREQEEQMREQEEQMLKQK 282

Query: 404 --TEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSE 461
             TE  ++   + +Q  +  ++ RE + Q  EQ++Q+ E ++++    ++     +++ E
Sbjct: 283 EQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWE 342

Query: 462 ALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNML 516
               +  Q+EQ       + K + ++ K  E  MR+ +    +  +++ K    +
Sbjct: 343 QKEQMWKQEEQMGEQEEQMQKQEEQVRKQ-EEQMRKQEEQMRKQEEQMRKQEEQM 396



 Score = 49.7 bits (117), Expect = 2e-05
 Identities = 60/361 (16%), Positives = 163/361 (45%), Gaps = 14/361 (3%)

Query: 228 LAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEG 287
           +  I   +L+ K  E++  L QL E + ++ + +I++    ++  K  + +   +   EG
Sbjct: 1   MPRITNEELKEKNAELQEEL-QLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEG 59

Query: 288 KFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDR 347
              Q++E++  +R     +     ++  Q  + R +   + +Q   ++  E ++ E + +
Sbjct: 60  ---QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQ 116

Query: 348 INDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEIL 407
           + + E +   ++E   ++ +       E++ +++EQ+   Q+ + E  ++       E  
Sbjct: 117 VREQEGQ---VREQEGQVREQE-GQVREQEGQVREQE--GQVREQEGQVREQEGQVREQE 170

Query: 408 DRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIK 467
            +++ +  Q  +   + RE + Q  EQ+ Q+ E ++++    ++     +++ E    ++
Sbjct: 171 GQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMR 230

Query: 468 AQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQ 527
            Q+EQ       + K + ++ K  E+  ++ +    +  Q  E+   ML  + +  ++ Q
Sbjct: 231 KQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQ 290

Query: 528 M-EVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQL---KDIAYGTKQYKFKP 583
             E E   R+ E   ++ E ++ +    +  +  ++ K E Q+   K+  +  K+  +K 
Sbjct: 291 TGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQ 350

Query: 584 E 584
           E
Sbjct: 351 E 351


>gi|38045898 RAB6-interacting protein 2 isoform epsilon [Homo
           sapiens]
          Length = 1116

 Score = 83.6 bits (205), Expect = 1e-15
 Identities = 125/605 (20%), Positives = 257/605 (42%), Gaps = 109/605 (18%)

Query: 12  LPVKDTGLNLFGMGGLQETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQ 71
           + +KD+ ++    G        + +KS  A+S   REE E + + ++      + H++  
Sbjct: 384 IEMKDSKISSMERGLRDLEEEIQMLKSNGALSTEEREE-EMKQMEVY------RSHSKFM 436

Query: 72  EDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHEL---EKQNET 128
           ++K++++  +L    + + ++E +    K  G   E+ ++ ++L  K  EL   + + ET
Sbjct: 437 KNKVEQLKEELS---SKEAQWEELK--KKAAGLQAEIGQVKQELSRKDTELLALQTKLET 491

Query: 129 LKNRLISAKQQLQTQGYRQTPYNN----VQSRINTGRRKANENAGLQECPRKGIKFQDAD 184
           L N+   +KQ ++      T        +Q+ ++  R +  E   +     K I+    D
Sbjct: 492 LTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQ----D 547

Query: 185 VAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEI- 243
           +AE                  GEI +L++++  +  ++  L+   E L+ QLR KE ++ 
Sbjct: 548 MAEEKGTQ------------AGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMS 595

Query: 244 ------------------------------ELSLLQLREQQATDQRSNIRDNVEMIKLHK 273
                                         E ++ +L+EQ+  D+R    +     K  K
Sbjct: 596 SLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLK 655

Query: 274 QLVEKSNAL----SAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEK 329
            L EK + L    S  E   + L+E   +L  S     +    L + L++++ +C  +E 
Sbjct: 656 DLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMES 715

Query: 330 QL---HSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLK 386
           QL   H      R   E+ DRI  LE+E    K+   K        A  E  +L E   +
Sbjct: 716 QLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSK--------AQAEVDRLLEILKE 767

Query: 387 VQIAQLETALKSDLTDKTEILDRLKTE-RDQNEKLVQENRELQLQYLEQKQQLDELKKRI 445
           V+         ++  DK + +  L+ + +DQN+K+     + Q++  +  Q L+E ++R 
Sbjct: 768 VE---------NEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRR- 817

Query: 446 KLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAET 505
                  + N ++ S+ L     +K+ +  +L   ++   +I  + E  + + ++     
Sbjct: 818 -------EDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNA 870

Query: 506 VQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKL 565
            +++E+   +L+   K+    + E+E++  K+ + QQ      E+  HL ++RA R   L
Sbjct: 871 EKQVEE---LLMAMEKV----KQELESMKAKLSSTQQSL---AEKETHLTNLRAERRKHL 920

Query: 566 EAQLK 570
           E  L+
Sbjct: 921 EEVLE 925



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 78/417 (18%), Positives = 181/417 (43%), Gaps = 41/417 (9%)

Query: 175 RKGIKFQDADVAETPHPMFTKYGNSLLEEA---RGEIRNLENVIQSQRGQIEELEHLAEI 231
           RK ++ +++ ++ + + + T +   L +E    + E   +    +  R   EE +H+   
Sbjct: 169 RKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQ-- 226

Query: 232 LKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQ 291
           +  Q  + E  I+  L QL +Q ++  R+      E+ + + Q +   +   A E   ++
Sbjct: 227 MTIQALQDELRIQRDLNQLFQQDSSS-RTGEPCVAELTEENFQRLHAEHERQAKELFLLR 285

Query: 292 --LQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLE------KQLHSMKFSERRIEE 343
             L+E +  +      L A  + +   L+  + K  S +      ++   +  +E  +  
Sbjct: 286 KTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHH 345

Query: 344 LQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDK 403
           L+  +   EKE  +L+E   + +++A  +A  +  +   +    +I+ +E  L+ DL ++
Sbjct: 346 LESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLR-DLEEE 404

Query: 404 TEILDRLKTERDQNEKLVQENRELQLQYLE--------QKQQLDELKKRIKLYNQENDIN 455
            ++L         N  L  E RE +++ +E         K ++++LK+ +       +  
Sbjct: 405 IQML-------KSNGALSTEEREEEMKQMEVYRSHSKFMKNKVEQLKEEL----SSKEAQ 453

Query: 456 ADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNM 515
            +EL +    ++A+  Q   +LS   + D+E+   L+  +  L    +++ Q +E  +  
Sbjct: 454 WEELKKKAAGLQAEIGQVKQELS---RKDTEL-LALQTKLETLTNQFSDSKQHIEVLKES 509

Query: 516 LIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLD---IRAARIHKLEAQL 569
           L  + +     Q EV+A+  ++E  +     K +Q   + +    +A  IH L+  L
Sbjct: 510 LTAKEQRAAILQTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGTQAGEIHDLKDML 566



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 97/537 (18%), Positives = 216/537 (40%), Gaps = 60/537 (11%)

Query: 11  DLPVKDTGLNLFGMGGLQETSTTRTMKSRQAVSRVSREEL---EDRFLRLHDENILLKQH 67
           +L  KDT   L  +    ET T +   S+Q +  V +E L   E R   L  E   L+  
Sbjct: 474 ELSRKDT--ELLALQTKLETLTNQFSDSKQHIE-VLKESLTAKEQRAAILQTEVDALRLR 530

Query: 68  ARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNE 127
             ++E  + +   ++  +  +K           + G   ++++M++  + KV+ L+K+ E
Sbjct: 531 LEEKETMLNKKTKQIQDMAEEKGT---------QAGEIHDLKDMLDVKERKVNVLQKKIE 581

Query: 128 TLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQ-DADVA 186
            L+ +L   ++Q+ +   R        +  +T      E    +E   + +K Q D D  
Sbjct: 582 NLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDER 641

Query: 187 ETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEEL-EHLAEILKTQLRRKENEIEL 245
           E    +   Y   L ++ + ++  L+  +  +   + +L EH + +  + L++      L
Sbjct: 642 EKQEEI-DNYKKDL-KDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTL 699

Query: 246 SL-LQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQ-------- 296
            + L+ ++++     S ++   E     +   E S+ +  +E +  + +++         
Sbjct: 700 EIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKDESSKAQAEVD 759

Query: 297 RTLRISHDALMANGD------ELNMQLKEQRLKCCSLE-KQLHSMKFSERRIEEL---QD 346
           R L I  +      D      EL  Q+K+Q  K  +L+ K+    K S + +EE    +D
Sbjct: 760 RLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRRED 819

Query: 347 RIND---------------LEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQ 391
            +ND               +E+  E L+E+     +     A EE  +   ++   ++  
Sbjct: 820 NLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQVEELLM 879

Query: 392 LETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQE 451
               +K +L      L   +    + E  +   R  + ++LE  + L+  ++ +     E
Sbjct: 880 AMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLE--EVLEMKQEALLAAISE 937

Query: 452 NDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQE 508
            D N      ALL + + K++   +++ L +    + + L++  +      A+  ++
Sbjct: 938 KDANI-----ALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKLMADNYED 989


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score = 82.8 bits (203), Expect = 2e-15
 Identities = 140/662 (21%), Positives = 267/662 (40%), Gaps = 120/662 (18%)

Query: 24   MGGLQETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHAR--KQEDKIKRMATK 81
            M GL ET   +  K ++A+    ++ L+D        NIL K   +  +Q D ++    +
Sbjct: 985  MAGLDET-IAKLSKEKKALQETHQQTLDDLQAEEDKVNILTKAKTKLEQQVDDLEGSLEQ 1043

Query: 82   LIRLVNDKKRYERVGGGPKRLGRD--VEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQ 139
              +L  D +R +R   G  +L ++  ++ME   +QL EK   LEK+   + N +   + +
Sbjct: 1044 EKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQLDEK---LEKKEFEISNLISKIEDE 1100

Query: 140  LQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNS 199
               +   Q     +Q+RI     +  E    +   R   + Q +D++     +  +    
Sbjct: 1101 QAVEIQLQKKIKELQARIE----ELGEEIEAERASRAKAEKQRSDLSRELEEISER---- 1152

Query: 200  LLEEARGEI-------RNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLRE 252
             LEEA G         +  E   Q  R  +EE     E +   LR+K  +   S+ +L E
Sbjct: 1153 -LEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMVAALRKKHAD---SMAELGE 1208

Query: 253  QQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDE 312
            Q          DN++ +K                    +L++++  L++  D L +N + 
Sbjct: 1209 QI---------DNLQRVKQ-------------------KLEKEKSELKMETDDLSSNAEA 1240

Query: 313  LNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKEN---YDKLYDSA 369
            ++         C SLE Q+  +K  E   EE Q  INDL  +R  L+     Y +  D  
Sbjct: 1241 ISKAKGNLEKMCRSLEDQVSELKTKE---EEQQRLINDLTAQRARLQTEAGEYSRQLDE- 1296

Query: 370  FSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQ------------- 416
               A   Q    +Q    QI +L+  L+ +   K  +   L++ R               
Sbjct: 1297 -KDALVSQLSRSKQASTQQIEELKHQLEEETKAKNALAHALQSSRHDCDLLREQYEEEQE 1355

Query: 417  ------------NEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALL 464
                        N ++ Q   + +   +++ ++L+E KK++    QE + + + ++    
Sbjct: 1356 GKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQEAEEHVEAVNAKCA 1415

Query: 465  LIKAQK--------------EQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELE 510
             ++  K              E+ N   + L K     +K L    ++ + T AE     +
Sbjct: 1416 SLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQKYEETQAELEASQK 1475

Query: 511  KTRNMLIMQHKINKDYQM---EVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEA 567
            ++R++     K+   Y+    ++E + R+ +NLQQ+     EQ          +IH+LE 
Sbjct: 1476 ESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAE----GGKQIHELEK 1531

Query: 568  QLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENL-FEIHINKVTFSSEVLQASGD 626
              K +       + K EI    +++E + ++  E G+ L  ++ +N+V   SEV +   +
Sbjct: 1532 IKKQVE------QEKCEIQA--ALEEAEASLEHEEGKILRIQLELNQV--KSEVDRKIAE 1581

Query: 627  KE 628
            K+
Sbjct: 1582 KD 1583



 Score = 67.8 bits (164), Expect = 6e-11
 Identities = 122/599 (20%), Positives = 250/599 (41%), Gaps = 99/599 (16%)

Query: 37   KSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVG 96
            K   A S   R+ELE++ + L  E   L+   + + D +     +  +L+ +K + E   
Sbjct: 863  KDELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLE--- 919

Query: 97   GGPKRLGRDVEMEEMIE--------QLQEKVHELEKQNETLKNRLISA-KQQLQTQGYRQ 147
               K +    E EE I         +L+++  EL+K  + L+  L    K++  T+   +
Sbjct: 920  AKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAKVEKEKHATENKVK 979

Query: 148  TPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGE 207
                 +     T  + + E   LQE  ++ +    A+  +           ++L +A+ +
Sbjct: 980  NLTEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDKV----------NILTKAKTK 1029

Query: 208  IRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVE 267
               LE  +    G +E+ + L   L+   R+ E +++L+      Q++T    N +  ++
Sbjct: 1030 ---LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLA------QESTMDMENDKQQLD 1080

Query: 268  MIKLHKQLVEKSNALSAMEGKF---IQLQEKQRTLRISHDALMANGDELNMQLKEQRLKC 324
              KL K+  E SN +S +E +    IQLQ+K + L+       A  +EL  +++ +R   
Sbjct: 1081 E-KLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQ-------ARIEELGEEIEAERASR 1132

Query: 325  CSLEKQLHSMKFSERRIEELQDRIN----------DLEKEREL----LKENYDK--LYDS 368
               EKQ   +    R +EE+ +R+           +L K+RE     L+ + ++  L   
Sbjct: 1133 AKAEKQRSDL---SRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHE 1189

Query: 369  AFSAA-----HEEQWKLKE-----QQLKVQIAQLETALK---SDLTDKTEILDR------ 409
            A  AA      +   +L E     Q++K ++ + ++ LK    DL+   E + +      
Sbjct: 1190 AMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLE 1249

Query: 410  ------------LKTERDQNEKLVQ----ENRELQLQYLEQKQQLDELKKRIKLYNQEND 453
                        LKT+ ++ ++L+     +   LQ +  E  +QLDE    +   ++   
Sbjct: 1250 KMCRSLEDQVSELKTKEEEQQRLINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQ 1309

Query: 454  INADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTR 513
             +  ++ E    ++ + + KN  L+  ++        L     E Q   AE  + L K  
Sbjct: 1310 ASTQQIEELKHQLEEETKAKNA-LAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKAN 1368

Query: 514  NMLIM-QHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKD 571
            + +   + K   D     E +    + L Q  + + E++V  ++ + A + K + +L++
Sbjct: 1369 SEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ-EAEEHVEAVNAKCASLEKTKQRLQN 1426



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 95/417 (22%), Positives = 178/417 (42%), Gaps = 62/417 (14%)

Query: 230  EILKTQLRRKENEIELSLL-------QLREQQATDQRSNIRDNVEM-----IKLHKQLVE 277
            E+ K++ +RKE E ++  L       QL+ Q   D  ++  +  E      I+L  ++ E
Sbjct: 865  ELAKSEAKRKELEEKMVTLLKEKNDLQLQVQSEADSLADAEERCEQLIKNKIQLEAKIKE 924

Query: 278  KSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFS 337
             +      E    +L  K+R L      L  + D+L + L +       +EK+ H+ +  
Sbjct: 925  VTERAEEEEEINAELTAKKRKLEDECSELKKDIDDLELTLAK-------VEKEKHATENK 977

Query: 338  ERRIEE----LQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKL---KEQQLKVQIA 390
             + + E    L + I  L KE++ L+E + +  D     A E++  +    + +L+ Q+ 
Sbjct: 978  VKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDDL--QAEEDKVNILTKAKTKLEQQVD 1035

Query: 391  QLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQ 450
             LE +L+ +   + + L+R K + + + KL QE+    +     KQQLDE     KL  +
Sbjct: 1036 DLEGSLEQEKKLRMD-LERAKRKLEGDLKLAQEST---MDMENDKQQLDE-----KLEKK 1086

Query: 451  ENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELE 510
            E +I+        L+ K + EQ              +   L++ ++ELQA   E  +E+E
Sbjct: 1087 EFEISN-------LISKIEDEQA-------------VEIQLQKKIKELQARIEELGEEIE 1126

Query: 511  KTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLK 570
              R       K   D   E+E ++ ++E        +VE    L   R A   KL   L+
Sbjct: 1127 AERASRAKAEKQRSDLSRELEEISERLEEAGGATSAQVE----LNKKREAEFQKLRRDLE 1182

Query: 571  DIAYGTKQYKFKPEIMPDDSVDEFDETI-HLERGENLFEIHINKVTFSSEVLQASGD 626
            +     +           DS+ E  E I +L+R +   E   +++   ++ L ++ +
Sbjct: 1183 EATLQHEAMVAALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAE 1239



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 128/614 (20%), Positives = 258/614 (42%), Gaps = 123/614 (20%)

Query: 58   HDENILLKQHARKQEDK--IKRMATKLIRLVNDKK---------RYERVGGGPKRLGRDV 106
            HD ++L +Q+  +QE K  ++R  +K    V   +         R E +    K+L + +
Sbjct: 1341 HDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTKYETDAIQRTEELEEAKKKLAQRL 1400

Query: 107  -EMEEMIEQLQEKVHELEKQNETLKNR----LISAKQQLQTQGYRQTPYNNVQSRINTGR 161
             E EE +E +  K   LEK  + L+N     ++  ++             N    ++  +
Sbjct: 1401 QEAEEHVEAVNAKCASLEKTKQRLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWK 1460

Query: 162  RKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSL--LEEARGEIRNLENVIQSQR 219
            +K  E     E  +K  +    ++ +  +     Y  SL  LE  R E +NL+  I    
Sbjct: 1461 QKYEETQAELEASQKESRSLSTELFKVKNV----YEESLDQLETLRRENKNLQQEISDLT 1516

Query: 220  GQIEE---LEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEM----IKLH 272
             QI E     H  E +K Q+ +++ EI+ +L +       ++   +R  +E+     ++ 
Sbjct: 1517 EQIAEGGKQIHELEKIKKQVEQEKCEIQAALEEAEASLEHEEGKILRIQLELNQVKSEVD 1576

Query: 273  KQLVEKSNALSAMEGKFIQLQEKQRT-----LRISHDALMAN----GD--ELNMQLKE-Q 320
            +++ EK   +  ++    ++ E  ++     +R  +DAL       GD  E+ +QL    
Sbjct: 1577 RKIAEKDEEIDQLKRNHTRVVETMQSTLDAEIRSRNDALRVKKKMEGDLNEMEIQLNHAN 1636

Query: 321  RLKCCSL-----------EKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSA 369
            RL   SL           E QLH +  + R  E+L++++  +E+   LL+   ++L+  A
Sbjct: 1637 RLAAESLRNYRNTQGILKETQLH-LDDALRGQEDLKEQLAIVERRANLLQAEIEELW--A 1693

Query: 370  FSAAHEEQWKLKEQQL-----KVQ-------------------IAQLETAL--------- 396
                 E   K+ EQ+L     +VQ                   ++QL++ +         
Sbjct: 1694 TLEQTERSRKIAEQELLDASERVQLLHTQNTSLINTKKKLENDVSQLQSEVEEVIQESRN 1753

Query: 397  -----KSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQE 451
                 K  +TD   + + LK E+D +  L +  + L+    + + +LDE  +++ L   +
Sbjct: 1754 AEEKAKKAITDAAMMAEELKKEQDTSAHLERMKKNLEQTVKDLQHRLDE-AEQLALKGGK 1812

Query: 452  NDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDL---ERSMRELQATHAETVQE 508
              I           ++A+  +  G++    K ++E  K L   ER ++EL      T Q 
Sbjct: 1813 KQIQK---------LEARVRELEGEVENEQKRNAEAVKGLRKHERRVKEL------TYQT 1857

Query: 509  LEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHL----------LDIR 558
             E  +N+L +Q  ++K  Q +V++  R+ E  ++     + ++  L           DI 
Sbjct: 1858 EEDRKNVLRLQDLVDK-LQAKVKSYKRQAEEAEEQSNANLSKFRKLQHELEEAEERADIA 1916

Query: 559  AARIHKLEAQLKDI 572
             ++++KL  + +++
Sbjct: 1917 ESQVNKLRVKSREV 1930



 Score = 40.0 bits (92), Expect = 0.014
 Identities = 49/228 (21%), Positives = 101/228 (44%), Gaps = 16/228 (7%)

Query: 391  QLETALKSDLTDKT-----EILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRI 445
            +++  LKS  T+K      E   + K E  ++E   +E  E  +  L++K  L     ++
Sbjct: 838  KIKPLLKSAETEKEMATMKEEFQKTKDELAKSEAKRKELEEKMVTLLKEKNDL-----QL 892

Query: 446  KLYNQENDI-NADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAE 504
            ++ ++ + + +A+E  E L+  K Q E K  +++   + + EIN +L    R+L+   +E
Sbjct: 893  QVQSEADSLADAEERCEQLIKNKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSE 952

Query: 505  TVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHK 564
              ++++     L    K     + +V+ +T +M  L +      ++   L +     +  
Sbjct: 953  LKKDIDDLELTLAKVEKEKHATENKVKNLTEEMAGLDETIAKLSKEKKALQETHQQTLDD 1012

Query: 565  LEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDE----TIHLERGENLFE 608
            L+A+   +   TK  K K E   DD     ++     + LER +   E
Sbjct: 1013 LQAEEDKVNILTKA-KTKLEQQVDDLEGSLEQEKKLRMDLERAKRKLE 1059


>gi|34577114 cytomatrix protein p110 [Homo sapiens]
          Length = 957

 Score = 82.0 bits (201), Expect = 3e-15
 Identities = 127/604 (21%), Positives = 253/604 (41%), Gaps = 91/604 (15%)

Query: 29  ETSTTRTMKSRQAVSRVS-------REELEDRFLR--LHDENILLKQHARKQ--EDKIKR 77
           E    RT +  +A S+VS       ++E E+  LR  LH  + L  + A+ +  +  I+ 
Sbjct: 323 EDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEPAKTKALQTVIEM 382

Query: 78  MATKL------IRLVNDKKRYERVGGGPKRLGRDVEMEEM------IEQLQEKVHELEKQ 125
             TK+      IR + D+ +  +  G      R+ E++++       + ++ K+ +L+++
Sbjct: 383 KDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSKFMKTKIDQLKQE 442

Query: 126 NETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADV 185
               ++ L++ + +L+T   + +        +        + A + +     ++ +  + 
Sbjct: 443 LSKKESELLALQTKLETLSNQNSDCKQHIEVLKESLTAKEQRAAILQTEVDALRLR-LEE 501

Query: 186 AETPHPMFTKYGNSLLEEA---RGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENE 242
            E+     TK    L EE     GEIR+++++++ +  +I  L+   E L+ QLR K+ +
Sbjct: 502 KESFLNKKTKQLQDLTEEKGTLAGEIRDMKDMLEVKERKINVLQKKIENLQEQLRDKDKQ 561

Query: 243 I-------------------------------ELSLLQLREQQATDQRSNIRDNVEMIKL 271
           +                               E  + +L+EQ+  D R  + +     K 
Sbjct: 562 LTNLKDRVKSLQTDSSNTDTALATLEEALSEKERIIERLKEQRERDDRERLEEIESFRKE 621

Query: 272 HKQLVEKSNALSA----MEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSL 327
           +K L EK NAL A     E   I L+E   +L  +     +    L + +++++ +C  L
Sbjct: 622 NKDLKEKVNALQAELTEKESSLIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEECSKL 681

Query: 328 EKQL---HSMKFSERRIEELQDRINDLEKERELLKE-------NYDKLYDSAFSAAHEEQ 377
           E QL   H+++   R   E  D+I  L+KE    ++         D+L +      +E+ 
Sbjct: 682 EAQLKKAHNIEDDSRMNPEFADQIKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKN 741

Query: 378 WKLKEQQLKVQIAQLETALKSDLTDKTEILDRLK----TERDQNEKLVQE--NRELQLQY 431
            K K      +IA+LE+     + D+ + +  LK     E+ +N +L++E   RE  +  
Sbjct: 742 DKDK------KIAELESLTLRHMKDQNKKVANLKHNQQLEKKKNAQLLEEVRRREDSMAD 795

Query: 432 LEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDL 491
             Q  Q++EL   ++   QE D     L+     + A+KE      + L  +  E  K L
Sbjct: 796 NSQHLQIEELMNALEKTRQELDATKARLASTQQSL-AEKE------AHLANLRIERRKQL 848

Query: 492 ERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQY 551
           E  +   Q      + E +    +L +     K  Q EV A+ R+ + L    + + +  
Sbjct: 849 EEILEMKQEALLAAISEKDANIALLELSASKKKKTQEEVMALKREKDRLVHQLKQQTQNR 908

Query: 552 VHLL 555
           + L+
Sbjct: 909 MKLM 912



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 98/474 (20%), Positives = 198/474 (41%), Gaps = 67/474 (14%)

Query: 104 RDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRK 163
           R V    M++ LQ ++ EL+++N+ L+  L     +L +       + + + +     RK
Sbjct: 140 RQVRDSTMLD-LQAQLKELQRENDLLRKELDIKDSKLGSSMNSIKTFWSPELKKERVLRK 198

Query: 164 ANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIE 223
                  +E  R  +  +   V+   +        +L +E R + R+L +++Q + G   
Sbjct: 199 -------EEAARMSVLKEQMRVSHEENQHLQLTIQALQDELRTQ-RDLNHLLQQESGNRG 250

Query: 224 ELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALS 283
                 E+ +   RR + E +    +L   + T +   +R   +   L+ +       L 
Sbjct: 251 AEHFTIELTEENFRRLQAEHDRQAKELFLLRKTLEEMELRIETQKQTLNARDESIKKLLE 310

Query: 284 AMEGKFIQLQ----EKQRTLR-------ISH-DALMANGDELNMQLKEQRLKCCSLEKQL 331
            ++ K +  +    + +RT R       +SH + ++   ++ N+ L+E+  +   L+ + 
Sbjct: 311 MLQSKGLPSKSLEDDNERTRRMAEAESQVSHLEVILDQKEKENIHLREELHRRSQLQPEP 370

Query: 332 HSMK-------FSERRIEELQDRINDLEKERELLKEN-YDKLYDSAFSAAHEEQWKLKEQ 383
              K         + +I  L+  I DLE E ++LK N      D        E +K   +
Sbjct: 371 AKTKALQTVIEMKDTKIASLERNIRDLEDEIQMLKANGVLNTEDREEEIKQIEVYKSHSK 430

Query: 384 QLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKK 443
            +K +I QL+  L    ++   +  +L+T  +QN               + KQ ++ LK+
Sbjct: 431 FMKTKIDQLKQELSKKESELLALQTKLETLSNQNS--------------DCKQHIEVLKE 476

Query: 444 RIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHA 503
            +    Q   I   E+ +AL L   +KE      SFL K   ++     + + E + T A
Sbjct: 477 SLTAKEQRAAILQTEV-DALRLRLEEKE------SFLNKKTKQL-----QDLTEEKGTLA 524

Query: 504 ETVQELEKTRNML-IMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLD 556
             ++++   ++ML + + KIN         + +K+ENLQ+    K +Q  +L D
Sbjct: 525 GEIRDM---KDMLEVKERKIN--------VLQKKIENLQEQLRDKDKQLTNLKD 567


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 121/605 (20%), Positives = 247/605 (40%), Gaps = 76/605 (12%)

Query: 29   ETSTTRTMKSRQAVSRVSRE------ELEDRFLRLHDENILLKQHARKQEDKIK----RM 78
            E    +  KSRQ + ++ R+      +  ++   L  +   LK    K+E++++    R+
Sbjct: 1040 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1099

Query: 79   ATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKV-----HELEKQNETLKNRL 133
              ++ +  N  K+   + G    L  D++ E       EK       ELE     L++ L
Sbjct: 1100 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL 1159

Query: 134  ISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMF 193
             S   Q + +  R+     ++  ++   R  +  A +QE  +K             H   
Sbjct: 1160 DSTATQQELRAKREQEVTVLKKALDEETR--SHEAQVQEMRQK-------------HAQA 1204

Query: 194  TKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEIL---KTQLRRKENEIELSLLQL 250
             +     LE+ +    NL+   Q+   +  +L     +L   K ++  K+ ++E  + +L
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264

Query: 251  REQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFI-----------QLQEKQRTL 299
            + + +  +R+    N ++ KL  ++   +  L+  EGK I           QLQ+ Q  L
Sbjct: 1265 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1324

Query: 300  RISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKER---- 355
            +      +    +L    +E+      L++++ + +  ER I  L  +++D +K+     
Sbjct: 1325 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1384

Query: 356  ---ELLKENYDKLYDSAFSAAHEEQWKL----KEQQLKVQIAQLETALKSDLTDKTEILD 408
               E L+E   +      +   + + K     K ++ K ++ Q    L  DL ++ +++ 
Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444

Query: 409  RLKTERDQNEKLVQENRELQLQYLEQKQQLD------ELKKRIKLYNQENDINA-DELSE 461
             L+ ++ + ++L+ E + +  +Y +++ + +      E K        E  + A +EL  
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1504

Query: 462  ALLLIKAQKEQKNGDLSFLVKVDSEINKD---LERSMRELQATHAETVQELEKTR----- 513
               ++KA+ E        + K   E+ K    LE  M E++    E   EL+ T      
Sbjct: 1505 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1564

Query: 514  ---NMLIMQHKINKDYQMEVEAVTRKMENLQQ---DYELKVEQYVHLLDIRAARIHKLEA 567
               NM  ++ +  +D Q   E    K   LQ+   +YE ++E       + AA   KLE 
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1624

Query: 568  QLKDI 572
             LKD+
Sbjct: 1625 DLKDL 1629



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 130/606 (21%), Positives = 252/606 (41%), Gaps = 68/606 (11%)

Query: 37   KSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVG 96
            K RQ  +    +ELE +  +L +E  LL++  + + +         +RL   K+  E + 
Sbjct: 865  KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL 924

Query: 97   GGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSR 156
                      EME  +E+ +++  +L+ + + +  +++  ++QL+ +   +      +  
Sbjct: 925  H---------EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 975

Query: 157  INTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQ 216
                 +K  +   + +     +  +   + E    + T      L E   + +NL  +  
Sbjct: 976  AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN-----LAEEEEKAKNLTKLKN 1030

Query: 217  SQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRD-NVEMIKLHKQL 275
                 I ELE    + K +  R+E E    L +  E  A+D    I D   ++ +L  QL
Sbjct: 1031 KHESMISELE--VRLKKEEKSRQELE---KLKRKLEGDASDFHEQIADLQAQIAELKMQL 1085

Query: 276  VEKSNALSAMEGKF-IQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSM 334
             +K   L A   +   ++ +K   L+   + L  +  +L   L  +R      EKQ   +
Sbjct: 1086 AKKEEELQAALARLDDEIAQKNNALKKIRE-LEGHISDLQEDLDSERAARNKAEKQKRDL 1144

Query: 335  -KFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLE 393
             +  E    EL+D ++    ++EL  +   ++  +    A +E+ +  E Q++ ++ Q  
Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEV--TVLKKALDEETRSHEAQVQ-EMRQKH 1201

Query: 394  TALKSDLTDKTEILDRLKTERDQNEK-LVQENREL--QLQYLEQ-KQQLDELKKRIKLYN 449
                 +LT++ E   R K   D+N++ L +EN +L  +L+ L Q KQ+++  KK+++   
Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1261

Query: 450  QENDINAD-------ELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATH 502
            QE             EL++ +  ++ + E   G L+       ++ KD+     +LQ T 
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321

Query: 503  AETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARI 562
             E +Q  E+TR  L +  K+    Q+E E   R     Q D E++ +Q +         I
Sbjct: 1322 -ELLQ--EETRQKLNVSTKLR---QLEEE---RNSLQDQLDEEMEAKQNLE------RHI 1366

Query: 563  HKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIH-LERGENLFEIHINKVTFSSEVL 621
              L  QL D                   + +F  T+  LE G+  F+  I  +T   E  
Sbjct: 1367 STLNIQLSD---------------SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEK 1411

Query: 622  QASGDK 627
             A+ DK
Sbjct: 1412 AAAYDK 1417



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 125/557 (22%), Positives = 229/557 (41%), Gaps = 79/557 (14%)

Query: 48   EELEDRFLRLHDENILLKQHARKQEDKIKRM--ATKLIRLVNDKKRYERVGGGPKRLGRD 105
            EELE     L D    L   A +QE + KR    T L + ++++ R         R    
Sbjct: 1146 EELEALKTELEDT---LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1202

Query: 106  VEMEEMIEQLQEKVH---ELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRR 162
              +EE+ EQL++       L+K  +TL+        +L+  G         Q++     +
Sbjct: 1203 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG---------QAKQEVEHK 1253

Query: 163  KANENAGLQECPRKGIKFQDA--DVAETPHPMFTKYGN--SLLEEARGEIRNLENVIQSQ 218
            K    A +QE   K    + A  ++ +  H +  +  +   +L EA G+   L   + S 
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313

Query: 219  RGQIEELEHLAEILKTQLRRKENEIELSLLQLRE-----QQATDQRSNIRDNVEM----- 268
              Q+++ +   E+L+ + R+K N +   L QL E     Q   D+    + N+E      
Sbjct: 1314 SSQLQDTQ---ELLQEETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369

Query: 269  -IKLH---KQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKC 324
             I+L    K+L + ++ + A+E    + Q++   L   ++   A  D+L       + + 
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1429

Query: 325  CSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWK----- 379
              L   L + +     +E+ Q + + L  E + +   Y    D A + A E++ K     
Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1489

Query: 380  --LKEQ-QLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQ 436
              L+E  + K ++ +    LK+++ D     D +     + EK     R L+ Q  E K 
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK---SKRALETQMEEMKT 1546

Query: 437  QLDELKKRIKLYNQENDINADELSEALLLIKAQ--KEQKNGDLSFLVKVDSEINKDLERS 494
            QL+EL         E+++ A E ++  L +  Q  K Q   DL    + + E  + L+R 
Sbjct: 1547 QLEEL---------EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1597

Query: 495  MRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHL 554
            + E +        ELE  R    +             A  +K+E   +D EL+ +  +  
Sbjct: 1598 LHEYET-------ELEDERKQRAL-----------AAAAKKKLEGDLKDLELQADSAIKG 1639

Query: 555  LDIRAARIHKLEAQLKD 571
             +    ++ KL+AQ+KD
Sbjct: 1640 REEAIKQLRKLQAQMKD 1656



 Score = 74.3 bits (181), Expect = 7e-13
 Identities = 127/624 (20%), Positives = 256/624 (41%), Gaps = 61/624 (9%)

Query: 28   QETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVN 87
            +E +  + ++  +  +    ++LED  L + D+N  L +  +  E++I  + T L     
Sbjct: 961  EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020

Query: 88   DKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQ 147
              K   ++    K      E+E  +++ ++   ELEK    L+       +Q+       
Sbjct: 1021 KAKNLTKLKN--KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA------ 1072

Query: 148  TPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGE 207
                ++Q++I   + +    A  +E  +  +   D ++A+  + +        + E  G 
Sbjct: 1073 ----DLQAQIAELKMQL---AKKEEELQAALARLDDEIAQKNNAL------KKIRELEGH 1119

Query: 208  IRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVE 267
            I +L+  + S+R    + E     L  +L   + E+E +L    +  AT Q    +   E
Sbjct: 1120 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL----DSTATQQELRAKREQE 1175

Query: 268  MIKLHKQLVEKSNALSA----MEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQ--- 320
            +  L K L E++ +  A    M  K  Q  E+            AN D+    L+++   
Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1235

Query: 321  ---RLKCCSLEKQ--LHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHE 375
                L+     KQ   H  K  E +++ELQ + +D E+ R  L +   KL +   S    
Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT-- 1293

Query: 376  EQWKLKEQQLK-VQIAQLETALKSDLTDKTEILDRLKTERDQN-----EKLVQENRELQL 429
                L E + K +++A+   +L S L D  E+L   +T +  N      +L +E   LQ 
Sbjct: 1294 --GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE-ETRQKLNVSTKLRQLEEERNSLQD 1350

Query: 430  QYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKN------GDLSFLVKV 483
            Q  E+ +    L++ I   N +   +  +L +    ++A +E K        +L+   + 
Sbjct: 1351 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1410

Query: 484  DSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQM---EVEAVTRKMENL 540
             +     LE++   LQ    + V +L+  R ++    K  + +     E + ++ K  + 
Sbjct: 1411 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADE 1470

Query: 541  QQDYELKV-EQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIH 599
            +   E +  E+    L +  A    LEA+ +++    K  K + E +   S D+  + +H
Sbjct: 1471 RDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDLV-SSKDDVGKNVH 1528

Query: 600  -LERGENLFEIHINKVTFSSEVLQ 622
             LE+ +   E  + ++    E L+
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELE 1552



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 121/601 (20%), Positives = 252/601 (41%), Gaps = 102/601 (16%)

Query: 27   LQETSTTRTMKSRQAVSRVSR-EELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRL 85
            LQ+T      ++RQ ++  ++  +LE+    L D+   L +    +++  + ++T  I+L
Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ---LDEEMEAKQNLERHISTLNIQL 1373

Query: 86   VNDKKRY-------ERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQ 138
             + KK+        E +  G KR  +  E+E + +Q +EK    +K  +T KNRL     
Sbjct: 1374 SDSKKKLQDFASTVEALEEGKKRFQK--EIENLTQQYEEKAAAYDKLEKT-KNRLQQELD 1430

Query: 139  QL--QTQGYRQTPYN----------------NVQSRINTGRRKANENAGLQECPRKGIK- 179
             L       RQ   N                N+ S+    R +A   A  +E     +  
Sbjct: 1431 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1490

Query: 180  -----FQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRG---QIEELEHLAEI 231
                  +  +  E  + M       L+       +N+  + +S+R    Q+EE++   E 
Sbjct: 1491 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1550

Query: 232  LKTQLRRKEN---EIELSL----------LQLREQQATDQRSNIRDNVEMIKLHKQLVEK 278
            L+ +L+  E+    +E+++          LQ R++Q  ++R  ++  +   +   +   K
Sbjct: 1551 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1610

Query: 279  SNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFS- 337
              AL+A   K  +L+   + L +  D+ +   +E   QL++ + +    +++L   + S 
Sbjct: 1611 QRALAAAAKK--KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR 1668

Query: 338  ----------ERRIEELQDRINDLE----------KERELLKENYDKLYDSAFSAAHEEQ 377
                      E++ + L+  +  L+          K+ +L KE   +   S+ S  +  Q
Sbjct: 1669 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1728

Query: 378  WKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQE---NRELQLQYLEQ 434
             +  +++L+ +IAQLE  L+ +  +   + DR++    Q E+L  E    R    +    
Sbjct: 1729 DE--KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786

Query: 435  KQQLDELKK--RIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLE 492
            +QQL+   K  R KL+  E                A K +    ++ L    +++ + +E
Sbjct: 1787 RQQLERQNKELRSKLHEMEG---------------AVKSKFKSTIAALEAKIAQLEEQVE 1831

Query: 493  RSMRELQATHAETVQELEKTRNMLIM---QHKINKDYQMEVEAVTRKMENLQQDYELKVE 549
            +  RE QA      Q+ +K + +L+    + K+ + Y+ + E    +++ L++  E   E
Sbjct: 1832 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1891

Query: 550  Q 550
            +
Sbjct: 1892 E 1892



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 80/386 (20%), Positives = 177/386 (45%), Gaps = 45/386 (11%)

Query: 214  VIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEM----- 268
            ++Q  R + E      E+ KT+ R+++ E EL  L+ +  Q T++++ +++ ++      
Sbjct: 844  LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903

Query: 269  -------IKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQR 321
                   ++L  +  E    L  ME +  + +++ + L+     +     +L  QL+E+ 
Sbjct: 904  AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963

Query: 322  LKCCSLEKQLHSMKFSERRIEE----LQDRINDLEKERELLKENYDKLYDSAFSAAHEEQ 377
                 L+ +  + +   +++E+    + D+ N L KER+LL+E   ++ D   + A EE+
Sbjct: 964  AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE---RISDLTTNLAEEEE 1020

Query: 378  WKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQ 437
             K K       + +L+   +S ++   E+  RLK E    ++L +  R+L+    +  +Q
Sbjct: 1021 -KAKN------LTKLKNKHESMIS---ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070

Query: 438  LDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVD---SEINKDL--- 491
            + +L+ +I     +     +EL  AL  +  +  QKN  L  + +++   S++ +DL   
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130

Query: 492  -------ERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDY 544
                   E+  R+L         ELE T +    Q ++    + EV  + + ++   + +
Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190

Query: 545  ELKVEQYVHLLDIRAARIHKLEAQLK 570
            E +V++   +    A  + +L  QL+
Sbjct: 1191 EAQVQE---MRQKHAQAVEELTEQLE 1213



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 102/489 (20%), Positives = 206/489 (42%), Gaps = 83/489 (16%)

Query: 39   RQAVSRVSREELEDRFLRLHDENILLKQ---------HARKQEDKIKRMATKLIRLVNDK 89
            RQ VS + +++ +   L   ++NI  K           AR++E K   +A  L   +  K
Sbjct: 1440 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1499

Query: 90   KRYERVGGGPKRLGRDVEMEEMI---EQLQEKVHELEKQNETLKNRLISAKQQLQT--QG 144
            +  ER     K      EME+++   + + + VHELEK    L+ ++   K QL+     
Sbjct: 1500 EELERTNKMLK-----AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554

Query: 145  YRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEA 204
             + T    ++  +N    K      LQ         Q+ +          +Y   L +E 
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDE-----QNEEKRRQLQRQLHEYETELEDER 1609

Query: 205  R-------------GEIRNLE----NVIQSQRGQIEELEHLAEILKTQLRR--------- 238
            +             G++++LE    + I+ +   I++L  L   +K   R          
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1669

Query: 239  ------KENE-----IELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEG 287
                  KENE     +E  L+QL+E  A  +R+  + ++E  +L ++L    +  +A++ 
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD 1729

Query: 288  KFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDR 347
            +  +L+ +   L    +    N + ++ ++++   +   L  +L + + + ++ E  + +
Sbjct: 1730 EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ 1789

Query: 348  INDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEIL 407
               LE++    KE   KL++     A + ++K     L+ +IAQLE  ++ +  +K    
Sbjct: 1790 ---LERQN---KELRSKLHE--MEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1841

Query: 408  DRLKTERDQNEKL---VQENRELQLQYLEQ-----------KQQLDELKKRIKLYNQEND 453
              LK +  + +++   V++ R++  QY EQ           K+QL+E ++  +  N    
Sbjct: 1842 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1901

Query: 454  INADELSEA 462
                EL EA
Sbjct: 1902 KLQRELDEA 1910


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 121/605 (20%), Positives = 247/605 (40%), Gaps = 76/605 (12%)

Query: 29   ETSTTRTMKSRQAVSRVSRE------ELEDRFLRLHDENILLKQHARKQEDKIK----RM 78
            E    +  KSRQ + ++ R+      +  ++   L  +   LK    K+E++++    R+
Sbjct: 1047 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1106

Query: 79   ATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKV-----HELEKQNETLKNRL 133
              ++ +  N  K+   + G    L  D++ E       EK       ELE     L++ L
Sbjct: 1107 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL 1166

Query: 134  ISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMF 193
             S   Q + +  R+     ++  ++   R  +  A +QE  +K             H   
Sbjct: 1167 DSTATQQELRAKREQEVTVLKKALDEETR--SHEAQVQEMRQK-------------HAQA 1211

Query: 194  TKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEIL---KTQLRRKENEIELSLLQL 250
             +     LE+ +    NL+   Q+   +  +L     +L   K ++  K+ ++E  + +L
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271

Query: 251  REQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFI-----------QLQEKQRTL 299
            + + +  +R+    N ++ KL  ++   +  L+  EGK I           QLQ+ Q  L
Sbjct: 1272 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1331

Query: 300  RISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKER---- 355
            +      +    +L    +E+      L++++ + +  ER I  L  +++D +K+     
Sbjct: 1332 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1391

Query: 356  ---ELLKENYDKLYDSAFSAAHEEQWKL----KEQQLKVQIAQLETALKSDLTDKTEILD 408
               E L+E   +      +   + + K     K ++ K ++ Q    L  DL ++ +++ 
Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451

Query: 409  RLKTERDQNEKLVQENRELQLQYLEQKQQLD------ELKKRIKLYNQENDINA-DELSE 461
             L+ ++ + ++L+ E + +  +Y +++ + +      E K        E  + A +EL  
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1511

Query: 462  ALLLIKAQKEQKNGDLSFLVKVDSEINKD---LERSMRELQATHAETVQELEKTR----- 513
               ++KA+ E        + K   E+ K    LE  M E++    E   EL+ T      
Sbjct: 1512 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1571

Query: 514  ---NMLIMQHKINKDYQMEVEAVTRKMENLQQ---DYELKVEQYVHLLDIRAARIHKLEA 567
               NM  ++ +  +D Q   E    K   LQ+   +YE ++E       + AA   KLE 
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631

Query: 568  QLKDI 572
             LKD+
Sbjct: 1632 DLKDL 1636



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 130/606 (21%), Positives = 252/606 (41%), Gaps = 68/606 (11%)

Query: 37   KSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVG 96
            K RQ  +    +ELE +  +L +E  LL++  + + +         +RL   K+  E + 
Sbjct: 872  KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL 931

Query: 97   GGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSR 156
                      EME  +E+ +++  +L+ + + +  +++  ++QL+ +   +      +  
Sbjct: 932  H---------EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 982

Query: 157  INTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQ 216
                 +K  +   + +     +  +   + E    + T      L E   + +NL  +  
Sbjct: 983  AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN-----LAEEEEKAKNLTKLKN 1037

Query: 217  SQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRD-NVEMIKLHKQL 275
                 I ELE    + K +  R+E E    L +  E  A+D    I D   ++ +L  QL
Sbjct: 1038 KHESMISELE--VRLKKEEKSRQELE---KLKRKLEGDASDFHEQIADLQAQIAELKMQL 1092

Query: 276  VEKSNALSAMEGKF-IQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSM 334
             +K   L A   +   ++ +K   L+   + L  +  +L   L  +R      EKQ   +
Sbjct: 1093 AKKEEELQAALARLDDEIAQKNNALKKIRE-LEGHISDLQEDLDSERAARNKAEKQKRDL 1151

Query: 335  -KFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLE 393
             +  E    EL+D ++    ++EL  +   ++  +    A +E+ +  E Q++ ++ Q  
Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEV--TVLKKALDEETRSHEAQVQ-EMRQKH 1208

Query: 394  TALKSDLTDKTEILDRLKTERDQNEK-LVQENREL--QLQYLEQ-KQQLDELKKRIKLYN 449
                 +LT++ E   R K   D+N++ L +EN +L  +L+ L Q KQ+++  KK+++   
Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1268

Query: 450  QENDINAD-------ELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATH 502
            QE             EL++ +  ++ + E   G L+       ++ KD+     +LQ T 
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328

Query: 503  AETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARI 562
             E +Q  E+TR  L +  K+    Q+E E   R     Q D E++ +Q +         I
Sbjct: 1329 -ELLQ--EETRQKLNVSTKLR---QLEEE---RNSLQDQLDEEMEAKQNLE------RHI 1373

Query: 563  HKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIH-LERGENLFEIHINKVTFSSEVL 621
              L  QL D                   + +F  T+  LE G+  F+  I  +T   E  
Sbjct: 1374 STLNIQLSD---------------SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEK 1418

Query: 622  QASGDK 627
             A+ DK
Sbjct: 1419 AAAYDK 1424



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 125/557 (22%), Positives = 229/557 (41%), Gaps = 79/557 (14%)

Query: 48   EELEDRFLRLHDENILLKQHARKQEDKIKRM--ATKLIRLVNDKKRYERVGGGPKRLGRD 105
            EELE     L D    L   A +QE + KR    T L + ++++ R         R    
Sbjct: 1153 EELEALKTELEDT---LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1209

Query: 106  VEMEEMIEQLQEKVH---ELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRR 162
              +EE+ EQL++       L+K  +TL+        +L+  G         Q++     +
Sbjct: 1210 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG---------QAKQEVEHK 1260

Query: 163  KANENAGLQECPRKGIKFQDA--DVAETPHPMFTKYGN--SLLEEARGEIRNLENVIQSQ 218
            K    A +QE   K    + A  ++ +  H +  +  +   +L EA G+   L   + S 
Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320

Query: 219  RGQIEELEHLAEILKTQLRRKENEIELSLLQLRE-----QQATDQRSNIRDNVEM----- 268
              Q+++ +   E+L+ + R+K N +   L QL E     Q   D+    + N+E      
Sbjct: 1321 SSQLQDTQ---ELLQEETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376

Query: 269  -IKLH---KQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKC 324
             I+L    K+L + ++ + A+E    + Q++   L   ++   A  D+L       + + 
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1436

Query: 325  CSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWK----- 379
              L   L + +     +E+ Q + + L  E + +   Y    D A + A E++ K     
Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1496

Query: 380  --LKEQ-QLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQ 436
              L+E  + K ++ +    LK+++ D     D +     + EK     R L+ Q  E K 
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK---SKRALETQMEEMKT 1553

Query: 437  QLDELKKRIKLYNQENDINADELSEALLLIKAQ--KEQKNGDLSFLVKVDSEINKDLERS 494
            QL+EL         E+++ A E ++  L +  Q  K Q   DL    + + E  + L+R 
Sbjct: 1554 QLEEL---------EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1604

Query: 495  MRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHL 554
            + E +        ELE  R    +             A  +K+E   +D EL+ +  +  
Sbjct: 1605 LHEYET-------ELEDERKQRAL-----------AAAAKKKLEGDLKDLELQADSAIKG 1646

Query: 555  LDIRAARIHKLEAQLKD 571
             +    ++ KL+AQ+KD
Sbjct: 1647 REEAIKQLRKLQAQMKD 1663



 Score = 74.3 bits (181), Expect = 7e-13
 Identities = 127/624 (20%), Positives = 256/624 (41%), Gaps = 61/624 (9%)

Query: 28   QETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVN 87
            +E +  + ++  +  +    ++LED  L + D+N  L +  +  E++I  + T L     
Sbjct: 968  EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027

Query: 88   DKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQ 147
              K   ++    K      E+E  +++ ++   ELEK    L+       +Q+       
Sbjct: 1028 KAKNLTKLKN--KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA------ 1079

Query: 148  TPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGE 207
                ++Q++I   + +    A  +E  +  +   D ++A+  + +        + E  G 
Sbjct: 1080 ----DLQAQIAELKMQL---AKKEEELQAALARLDDEIAQKNNAL------KKIRELEGH 1126

Query: 208  IRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVE 267
            I +L+  + S+R    + E     L  +L   + E+E +L    +  AT Q    +   E
Sbjct: 1127 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL----DSTATQQELRAKREQE 1182

Query: 268  MIKLHKQLVEKSNALSA----MEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQ--- 320
            +  L K L E++ +  A    M  K  Q  E+            AN D+    L+++   
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1242

Query: 321  ---RLKCCSLEKQ--LHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHE 375
                L+     KQ   H  K  E +++ELQ + +D E+ R  L +   KL +   S    
Sbjct: 1243 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT-- 1300

Query: 376  EQWKLKEQQLK-VQIAQLETALKSDLTDKTEILDRLKTERDQN-----EKLVQENRELQL 429
                L E + K +++A+   +L S L D  E+L   +T +  N      +L +E   LQ 
Sbjct: 1301 --GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE-ETRQKLNVSTKLRQLEEERNSLQD 1357

Query: 430  QYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKN------GDLSFLVKV 483
            Q  E+ +    L++ I   N +   +  +L +    ++A +E K        +L+   + 
Sbjct: 1358 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1417

Query: 484  DSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQM---EVEAVTRKMENL 540
             +     LE++   LQ    + V +L+  R ++    K  + +     E + ++ K  + 
Sbjct: 1418 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADE 1477

Query: 541  QQDYELKV-EQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIH 599
            +   E +  E+    L +  A    LEA+ +++    K  K + E +   S D+  + +H
Sbjct: 1478 RDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDLV-SSKDDVGKNVH 1535

Query: 600  -LERGENLFEIHINKVTFSSEVLQ 622
             LE+ +   E  + ++    E L+
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELE 1559



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 121/601 (20%), Positives = 252/601 (41%), Gaps = 102/601 (16%)

Query: 27   LQETSTTRTMKSRQAVSRVSR-EELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRL 85
            LQ+T      ++RQ ++  ++  +LE+    L D+   L +    +++  + ++T  I+L
Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ---LDEEMEAKQNLERHISTLNIQL 1380

Query: 86   VNDKKRY-------ERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQ 138
             + KK+        E +  G KR  +  E+E + +Q +EK    +K  +T KNRL     
Sbjct: 1381 SDSKKKLQDFASTVEALEEGKKRFQK--EIENLTQQYEEKAAAYDKLEKT-KNRLQQELD 1437

Query: 139  QL--QTQGYRQTPYN----------------NVQSRINTGRRKANENAGLQECPRKGIK- 179
             L       RQ   N                N+ S+    R +A   A  +E     +  
Sbjct: 1438 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1497

Query: 180  -----FQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRG---QIEELEHLAEI 231
                  +  +  E  + M       L+       +N+  + +S+R    Q+EE++   E 
Sbjct: 1498 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1557

Query: 232  LKTQLRRKEN---EIELSL----------LQLREQQATDQRSNIRDNVEMIKLHKQLVEK 278
            L+ +L+  E+    +E+++          LQ R++Q  ++R  ++  +   +   +   K
Sbjct: 1558 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1617

Query: 279  SNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFS- 337
              AL+A   K  +L+   + L +  D+ +   +E   QL++ + +    +++L   + S 
Sbjct: 1618 QRALAAAAKK--KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR 1675

Query: 338  ----------ERRIEELQDRINDLE----------KERELLKENYDKLYDSAFSAAHEEQ 377
                      E++ + L+  +  L+          K+ +L KE   +   S+ S  +  Q
Sbjct: 1676 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1735

Query: 378  WKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQE---NRELQLQYLEQ 434
             +  +++L+ +IAQLE  L+ +  +   + DR++    Q E+L  E    R    +    
Sbjct: 1736 DE--KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793

Query: 435  KQQLDELKK--RIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLE 492
            +QQL+   K  R KL+  E                A K +    ++ L    +++ + +E
Sbjct: 1794 RQQLERQNKELRSKLHEMEG---------------AVKSKFKSTIAALEAKIAQLEEQVE 1838

Query: 493  RSMRELQATHAETVQELEKTRNMLIM---QHKINKDYQMEVEAVTRKMENLQQDYELKVE 549
            +  RE QA      Q+ +K + +L+    + K+ + Y+ + E    +++ L++  E   E
Sbjct: 1839 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1898

Query: 550  Q 550
            +
Sbjct: 1899 E 1899



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 80/386 (20%), Positives = 177/386 (45%), Gaps = 45/386 (11%)

Query: 214  VIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEM----- 268
            ++Q  R + E      E+ KT+ R+++ E EL  L+ +  Q T++++ +++ ++      
Sbjct: 851  LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910

Query: 269  -------IKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQR 321
                   ++L  +  E    L  ME +  + +++ + L+     +     +L  QL+E+ 
Sbjct: 911  AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970

Query: 322  LKCCSLEKQLHSMKFSERRIEE----LQDRINDLEKERELLKENYDKLYDSAFSAAHEEQ 377
                 L+ +  + +   +++E+    + D+ N L KER+LL+E   ++ D   + A EE+
Sbjct: 971  AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE---RISDLTTNLAEEEE 1027

Query: 378  WKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQ 437
             K K       + +L+   +S ++   E+  RLK E    ++L +  R+L+    +  +Q
Sbjct: 1028 -KAKN------LTKLKNKHESMIS---ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077

Query: 438  LDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVD---SEINKDL--- 491
            + +L+ +I     +     +EL  AL  +  +  QKN  L  + +++   S++ +DL   
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137

Query: 492  -------ERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDY 544
                   E+  R+L         ELE T +    Q ++    + EV  + + ++   + +
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197

Query: 545  ELKVEQYVHLLDIRAARIHKLEAQLK 570
            E +V++   +    A  + +L  QL+
Sbjct: 1198 EAQVQE---MRQKHAQAVEELTEQLE 1220



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 102/489 (20%), Positives = 206/489 (42%), Gaps = 83/489 (16%)

Query: 39   RQAVSRVSREELEDRFLRLHDENILLKQ---------HARKQEDKIKRMATKLIRLVNDK 89
            RQ VS + +++ +   L   ++NI  K           AR++E K   +A  L   +  K
Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1506

Query: 90   KRYERVGGGPKRLGRDVEMEEMI---EQLQEKVHELEKQNETLKNRLISAKQQLQT--QG 144
            +  ER     K      EME+++   + + + VHELEK    L+ ++   K QL+     
Sbjct: 1507 EELERTNKMLK-----AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561

Query: 145  YRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEA 204
             + T    ++  +N    K      LQ         Q+ +          +Y   L +E 
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDE-----QNEEKRRQLQRQLHEYETELEDER 1616

Query: 205  R-------------GEIRNLE----NVIQSQRGQIEELEHLAEILKTQLRR--------- 238
            +             G++++LE    + I+ +   I++L  L   +K   R          
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1676

Query: 239  ------KENE-----IELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEG 287
                  KENE     +E  L+QL+E  A  +R+  + ++E  +L ++L    +  +A++ 
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD 1736

Query: 288  KFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDR 347
            +  +L+ +   L    +    N + ++ ++++   +   L  +L + + + ++ E  + +
Sbjct: 1737 EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ 1796

Query: 348  INDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEIL 407
               LE++    KE   KL++     A + ++K     L+ +IAQLE  ++ +  +K    
Sbjct: 1797 ---LERQN---KELRSKLHE--MEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1848

Query: 408  DRLKTERDQNEKL---VQENRELQLQYLEQ-----------KQQLDELKKRIKLYNQEND 453
              LK +  + +++   V++ R++  QY EQ           K+QL+E ++  +  N    
Sbjct: 1849 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1908

Query: 454  INADELSEA 462
                EL EA
Sbjct: 1909 KLQRELDEA 1917


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 121/605 (20%), Positives = 247/605 (40%), Gaps = 76/605 (12%)

Query: 29   ETSTTRTMKSRQAVSRVSRE------ELEDRFLRLHDENILLKQHARKQEDKIK----RM 78
            E    +  KSRQ + ++ R+      +  ++   L  +   LK    K+E++++    R+
Sbjct: 1047 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1106

Query: 79   ATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKV-----HELEKQNETLKNRL 133
              ++ +  N  K+   + G    L  D++ E       EK       ELE     L++ L
Sbjct: 1107 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL 1166

Query: 134  ISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMF 193
             S   Q + +  R+     ++  ++   R  +  A +QE  +K             H   
Sbjct: 1167 DSTATQQELRAKREQEVTVLKKALDEETR--SHEAQVQEMRQK-------------HAQA 1211

Query: 194  TKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEIL---KTQLRRKENEIELSLLQL 250
             +     LE+ +    NL+   Q+   +  +L     +L   K ++  K+ ++E  + +L
Sbjct: 1212 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1271

Query: 251  REQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFI-----------QLQEKQRTL 299
            + + +  +R+    N ++ KL  ++   +  L+  EGK I           QLQ+ Q  L
Sbjct: 1272 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1331

Query: 300  RISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKER---- 355
            +      +    +L    +E+      L++++ + +  ER I  L  +++D +K+     
Sbjct: 1332 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1391

Query: 356  ---ELLKENYDKLYDSAFSAAHEEQWKL----KEQQLKVQIAQLETALKSDLTDKTEILD 408
               E L+E   +      +   + + K     K ++ K ++ Q    L  DL ++ +++ 
Sbjct: 1392 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1451

Query: 409  RLKTERDQNEKLVQENRELQLQYLEQKQQLD------ELKKRIKLYNQENDINA-DELSE 461
             L+ ++ + ++L+ E + +  +Y +++ + +      E K        E  + A +EL  
Sbjct: 1452 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1511

Query: 462  ALLLIKAQKEQKNGDLSFLVKVDSEINKD---LERSMRELQATHAETVQELEKTR----- 513
               ++KA+ E        + K   E+ K    LE  M E++    E   EL+ T      
Sbjct: 1512 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1571

Query: 514  ---NMLIMQHKINKDYQMEVEAVTRKMENLQQ---DYELKVEQYVHLLDIRAARIHKLEA 567
               NM  ++ +  +D Q   E    K   LQ+   +YE ++E       + AA   KLE 
Sbjct: 1572 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1631

Query: 568  QLKDI 572
             LKD+
Sbjct: 1632 DLKDL 1636



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 130/606 (21%), Positives = 252/606 (41%), Gaps = 68/606 (11%)

Query: 37   KSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVG 96
            K RQ  +    +ELE +  +L +E  LL++  + + +         +RL   K+  E + 
Sbjct: 872  KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL 931

Query: 97   GGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSR 156
                      EME  +E+ +++  +L+ + + +  +++  ++QL+ +   +      +  
Sbjct: 932  H---------EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 982

Query: 157  INTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQ 216
                 +K  +   + +     +  +   + E    + T      L E   + +NL  +  
Sbjct: 983  AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN-----LAEEEEKAKNLTKLKN 1037

Query: 217  SQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRD-NVEMIKLHKQL 275
                 I ELE    + K +  R+E E    L +  E  A+D    I D   ++ +L  QL
Sbjct: 1038 KHESMISELE--VRLKKEEKSRQELE---KLKRKLEGDASDFHEQIADLQAQIAELKMQL 1092

Query: 276  VEKSNALSAMEGKF-IQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSM 334
             +K   L A   +   ++ +K   L+   + L  +  +L   L  +R      EKQ   +
Sbjct: 1093 AKKEEELQAALARLDDEIAQKNNALKKIRE-LEGHISDLQEDLDSERAARNKAEKQKRDL 1151

Query: 335  -KFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLE 393
             +  E    EL+D ++    ++EL  +   ++  +    A +E+ +  E Q++ ++ Q  
Sbjct: 1152 GEELEALKTELEDTLDSTATQQELRAKREQEV--TVLKKALDEETRSHEAQVQ-EMRQKH 1208

Query: 394  TALKSDLTDKTEILDRLKTERDQNEK-LVQENREL--QLQYLEQ-KQQLDELKKRIKLYN 449
                 +LT++ E   R K   D+N++ L +EN +L  +L+ L Q KQ+++  KK+++   
Sbjct: 1209 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1268

Query: 450  QENDINAD-------ELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATH 502
            QE             EL++ +  ++ + E   G L+       ++ KD+     +LQ T 
Sbjct: 1269 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1328

Query: 503  AETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARI 562
             E +Q  E+TR  L +  K+    Q+E E   R     Q D E++ +Q +         I
Sbjct: 1329 -ELLQ--EETRQKLNVSTKLR---QLEEE---RNSLQDQLDEEMEAKQNLE------RHI 1373

Query: 563  HKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIH-LERGENLFEIHINKVTFSSEVL 621
              L  QL D                   + +F  T+  LE G+  F+  I  +T   E  
Sbjct: 1374 STLNIQLSD---------------SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEK 1418

Query: 622  QASGDK 627
             A+ DK
Sbjct: 1419 AAAYDK 1424



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 125/557 (22%), Positives = 229/557 (41%), Gaps = 79/557 (14%)

Query: 48   EELEDRFLRLHDENILLKQHARKQEDKIKRM--ATKLIRLVNDKKRYERVGGGPKRLGRD 105
            EELE     L D    L   A +QE + KR    T L + ++++ R         R    
Sbjct: 1153 EELEALKTELEDT---LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1209

Query: 106  VEMEEMIEQLQEKVH---ELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRR 162
              +EE+ EQL++       L+K  +TL+        +L+  G         Q++     +
Sbjct: 1210 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG---------QAKQEVEHK 1260

Query: 163  KANENAGLQECPRKGIKFQDA--DVAETPHPMFTKYGN--SLLEEARGEIRNLENVIQSQ 218
            K    A +QE   K    + A  ++ +  H +  +  +   +L EA G+   L   + S 
Sbjct: 1261 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1320

Query: 219  RGQIEELEHLAEILKTQLRRKENEIELSLLQLRE-----QQATDQRSNIRDNVEM----- 268
              Q+++ +   E+L+ + R+K N +   L QL E     Q   D+    + N+E      
Sbjct: 1321 SSQLQDTQ---ELLQEETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1376

Query: 269  -IKLH---KQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKC 324
             I+L    K+L + ++ + A+E    + Q++   L   ++   A  D+L       + + 
Sbjct: 1377 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1436

Query: 325  CSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWK----- 379
              L   L + +     +E+ Q + + L  E + +   Y    D A + A E++ K     
Sbjct: 1437 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1496

Query: 380  --LKEQ-QLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQ 436
              L+E  + K ++ +    LK+++ D     D +     + EK     R L+ Q  E K 
Sbjct: 1497 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK---SKRALETQMEEMKT 1553

Query: 437  QLDELKKRIKLYNQENDINADELSEALLLIKAQ--KEQKNGDLSFLVKVDSEINKDLERS 494
            QL+EL         E+++ A E ++  L +  Q  K Q   DL    + + E  + L+R 
Sbjct: 1554 QLEEL---------EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1604

Query: 495  MRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHL 554
            + E +        ELE  R    +             A  +K+E   +D EL+ +  +  
Sbjct: 1605 LHEYET-------ELEDERKQRAL-----------AAAAKKKLEGDLKDLELQADSAIKG 1646

Query: 555  LDIRAARIHKLEAQLKD 571
             +    ++ KL+AQ+KD
Sbjct: 1647 REEAIKQLRKLQAQMKD 1663



 Score = 74.3 bits (181), Expect = 7e-13
 Identities = 127/624 (20%), Positives = 256/624 (41%), Gaps = 61/624 (9%)

Query: 28   QETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVN 87
            +E +  + ++  +  +    ++LED  L + D+N  L +  +  E++I  + T L     
Sbjct: 968  EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1027

Query: 88   DKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQ 147
              K   ++    K      E+E  +++ ++   ELEK    L+       +Q+       
Sbjct: 1028 KAKNLTKLKN--KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA------ 1079

Query: 148  TPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGE 207
                ++Q++I   + +    A  +E  +  +   D ++A+  + +        + E  G 
Sbjct: 1080 ----DLQAQIAELKMQL---AKKEEELQAALARLDDEIAQKNNAL------KKIRELEGH 1126

Query: 208  IRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVE 267
            I +L+  + S+R    + E     L  +L   + E+E +L    +  AT Q    +   E
Sbjct: 1127 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL----DSTATQQELRAKREQE 1182

Query: 268  MIKLHKQLVEKSNALSA----MEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQ--- 320
            +  L K L E++ +  A    M  K  Q  E+            AN D+    L+++   
Sbjct: 1183 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1242

Query: 321  ---RLKCCSLEKQ--LHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHE 375
                L+     KQ   H  K  E +++ELQ + +D E+ R  L +   KL +   S    
Sbjct: 1243 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT-- 1300

Query: 376  EQWKLKEQQLK-VQIAQLETALKSDLTDKTEILDRLKTERDQN-----EKLVQENRELQL 429
                L E + K +++A+   +L S L D  E+L   +T +  N      +L +E   LQ 
Sbjct: 1301 --GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE-ETRQKLNVSTKLRQLEEERNSLQD 1357

Query: 430  QYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKN------GDLSFLVKV 483
            Q  E+ +    L++ I   N +   +  +L +    ++A +E K        +L+   + 
Sbjct: 1358 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1417

Query: 484  DSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQM---EVEAVTRKMENL 540
             +     LE++   LQ    + V +L+  R ++    K  + +     E + ++ K  + 
Sbjct: 1418 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADE 1477

Query: 541  QQDYELKV-EQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIH 599
            +   E +  E+    L +  A    LEA+ +++    K  K + E +   S D+  + +H
Sbjct: 1478 RDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDLV-SSKDDVGKNVH 1535

Query: 600  -LERGENLFEIHINKVTFSSEVLQ 622
             LE+ +   E  + ++    E L+
Sbjct: 1536 ELEKSKRALETQMEEMKTQLEELE 1559



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 121/601 (20%), Positives = 252/601 (41%), Gaps = 102/601 (16%)

Query: 27   LQETSTTRTMKSRQAVSRVSR-EELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRL 85
            LQ+T      ++RQ ++  ++  +LE+    L D+   L +    +++  + ++T  I+L
Sbjct: 1324 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ---LDEEMEAKQNLERHISTLNIQL 1380

Query: 86   VNDKKRY-------ERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQ 138
             + KK+        E +  G KR  +  E+E + +Q +EK    +K  +T KNRL     
Sbjct: 1381 SDSKKKLQDFASTVEALEEGKKRFQK--EIENLTQQYEEKAAAYDKLEKT-KNRLQQELD 1437

Query: 139  QL--QTQGYRQTPYN----------------NVQSRINTGRRKANENAGLQECPRKGIK- 179
             L       RQ   N                N+ S+    R +A   A  +E     +  
Sbjct: 1438 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1497

Query: 180  -----FQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRG---QIEELEHLAEI 231
                  +  +  E  + M       L+       +N+  + +S+R    Q+EE++   E 
Sbjct: 1498 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1557

Query: 232  LKTQLRRKEN---EIELSL----------LQLREQQATDQRSNIRDNVEMIKLHKQLVEK 278
            L+ +L+  E+    +E+++          LQ R++Q  ++R  ++  +   +   +   K
Sbjct: 1558 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1617

Query: 279  SNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFS- 337
              AL+A   K  +L+   + L +  D+ +   +E   QL++ + +    +++L   + S 
Sbjct: 1618 QRALAAAAKK--KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR 1675

Query: 338  ----------ERRIEELQDRINDLE----------KERELLKENYDKLYDSAFSAAHEEQ 377
                      E++ + L+  +  L+          K+ +L KE   +   S+ S  +  Q
Sbjct: 1676 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1735

Query: 378  WKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQE---NRELQLQYLEQ 434
             +  +++L+ +IAQLE  L+ +  +   + DR++    Q E+L  E    R    +    
Sbjct: 1736 DE--KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1793

Query: 435  KQQLDELKK--RIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLE 492
            +QQL+   K  R KL+  E                A K +    ++ L    +++ + +E
Sbjct: 1794 RQQLERQNKELRSKLHEMEG---------------AVKSKFKSTIAALEAKIAQLEEQVE 1838

Query: 493  RSMRELQATHAETVQELEKTRNMLIM---QHKINKDYQMEVEAVTRKMENLQQDYELKVE 549
            +  RE QA      Q+ +K + +L+    + K+ + Y+ + E    +++ L++  E   E
Sbjct: 1839 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1898

Query: 550  Q 550
            +
Sbjct: 1899 E 1899



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 80/386 (20%), Positives = 177/386 (45%), Gaps = 45/386 (11%)

Query: 214  VIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEM----- 268
            ++Q  R + E      E+ KT+ R+++ E EL  L+ +  Q T++++ +++ ++      
Sbjct: 851  LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 910

Query: 269  -------IKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQR 321
                   ++L  +  E    L  ME +  + +++ + L+     +     +L  QL+E+ 
Sbjct: 911  AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 970

Query: 322  LKCCSLEKQLHSMKFSERRIEE----LQDRINDLEKERELLKENYDKLYDSAFSAAHEEQ 377
                 L+ +  + +   +++E+    + D+ N L KER+LL+E   ++ D   + A EE+
Sbjct: 971  AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE---RISDLTTNLAEEEE 1027

Query: 378  WKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQ 437
             K K       + +L+   +S ++   E+  RLK E    ++L +  R+L+    +  +Q
Sbjct: 1028 -KAKN------LTKLKNKHESMIS---ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1077

Query: 438  LDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVD---SEINKDL--- 491
            + +L+ +I     +     +EL  AL  +  +  QKN  L  + +++   S++ +DL   
Sbjct: 1078 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1137

Query: 492  -------ERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDY 544
                   E+  R+L         ELE T +    Q ++    + EV  + + ++   + +
Sbjct: 1138 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1197

Query: 545  ELKVEQYVHLLDIRAARIHKLEAQLK 570
            E +V++   +    A  + +L  QL+
Sbjct: 1198 EAQVQE---MRQKHAQAVEELTEQLE 1220



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 102/489 (20%), Positives = 206/489 (42%), Gaps = 83/489 (16%)

Query: 39   RQAVSRVSREELEDRFLRLHDENILLKQ---------HARKQEDKIKRMATKLIRLVNDK 89
            RQ VS + +++ +   L   ++NI  K           AR++E K   +A  L   +  K
Sbjct: 1447 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1506

Query: 90   KRYERVGGGPKRLGRDVEMEEMI---EQLQEKVHELEKQNETLKNRLISAKQQLQT--QG 144
            +  ER     K      EME+++   + + + VHELEK    L+ ++   K QL+     
Sbjct: 1507 EELERTNKMLK-----AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1561

Query: 145  YRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEA 204
             + T    ++  +N    K      LQ         Q+ +          +Y   L +E 
Sbjct: 1562 LQATEDAKLRLEVNMQALKGQFERDLQARDE-----QNEEKRRQLQRQLHEYETELEDER 1616

Query: 205  R-------------GEIRNLE----NVIQSQRGQIEELEHLAEILKTQLRR--------- 238
            +             G++++LE    + I+ +   I++L  L   +K   R          
Sbjct: 1617 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1676

Query: 239  ------KENE-----IELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEG 287
                  KENE     +E  L+QL+E  A  +R+  + ++E  +L ++L    +  +A++ 
Sbjct: 1677 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD 1736

Query: 288  KFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDR 347
            +  +L+ +   L    +    N + ++ ++++   +   L  +L + + + ++ E  + +
Sbjct: 1737 EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ 1796

Query: 348  INDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEIL 407
               LE++    KE   KL++     A + ++K     L+ +IAQLE  ++ +  +K    
Sbjct: 1797 ---LERQN---KELRSKLHE--MEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1848

Query: 408  DRLKTERDQNEKL---VQENRELQLQYLEQ-----------KQQLDELKKRIKLYNQEND 453
              LK +  + +++   V++ R++  QY EQ           K+QL+E ++  +  N    
Sbjct: 1849 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1908

Query: 454  INADELSEA 462
                EL EA
Sbjct: 1909 KLQRELDEA 1917


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 80.9 bits (198), Expect = 7e-15
 Identities = 121/605 (20%), Positives = 247/605 (40%), Gaps = 76/605 (12%)

Query: 29   ETSTTRTMKSRQAVSRVSRE------ELEDRFLRLHDENILLKQHARKQEDKIK----RM 78
            E    +  KSRQ + ++ R+      +  ++   L  +   LK    K+E++++    R+
Sbjct: 1040 EVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEEELQAALARL 1099

Query: 79   ATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKV-----HELEKQNETLKNRL 133
              ++ +  N  K+   + G    L  D++ E       EK       ELE     L++ L
Sbjct: 1100 DDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL 1159

Query: 134  ISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMF 193
             S   Q + +  R+     ++  ++   R  +  A +QE  +K             H   
Sbjct: 1160 DSTATQQELRAKREQEVTVLKKALDEETR--SHEAQVQEMRQK-------------HAQA 1204

Query: 194  TKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEIL---KTQLRRKENEIELSLLQL 250
             +     LE+ +    NL+   Q+   +  +L     +L   K ++  K+ ++E  + +L
Sbjct: 1205 VEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQEL 1264

Query: 251  REQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFI-----------QLQEKQRTL 299
            + + +  +R+    N ++ KL  ++   +  L+  EGK I           QLQ+ Q  L
Sbjct: 1265 QSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELL 1324

Query: 300  RISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKER---- 355
            +      +    +L    +E+      L++++ + +  ER I  L  +++D +K+     
Sbjct: 1325 QEETRQKLNVSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFA 1384

Query: 356  ---ELLKENYDKLYDSAFSAAHEEQWKL----KEQQLKVQIAQLETALKSDLTDKTEILD 408
               E L+E   +      +   + + K     K ++ K ++ Q    L  DL ++ +++ 
Sbjct: 1385 STVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS 1444

Query: 409  RLKTERDQNEKLVQENRELQLQYLEQKQQLD------ELKKRIKLYNQENDINA-DELSE 461
             L+ ++ + ++L+ E + +  +Y +++ + +      E K        E  + A +EL  
Sbjct: 1445 NLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAKEELER 1504

Query: 462  ALLLIKAQKEQKNGDLSFLVKVDSEINKD---LERSMRELQATHAETVQELEKTR----- 513
               ++KA+ E        + K   E+ K    LE  M E++    E   EL+ T      
Sbjct: 1505 TNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAKLR 1564

Query: 514  ---NMLIMQHKINKDYQMEVEAVTRKMENLQQ---DYELKVEQYVHLLDIRAARIHKLEA 567
               NM  ++ +  +D Q   E    K   LQ+   +YE ++E       + AA   KLE 
Sbjct: 1565 LEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEG 1624

Query: 568  QLKDI 572
             LKD+
Sbjct: 1625 DLKDL 1629



 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 130/606 (21%), Positives = 252/606 (41%), Gaps = 68/606 (11%)

Query: 37   KSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVG 96
            K RQ  +    +ELE +  +L +E  LL++  + + +         +RL   K+  E + 
Sbjct: 865  KERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEIL 924

Query: 97   GGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSR 156
                      EME  +E+ +++  +L+ + + +  +++  ++QL+ +   +      +  
Sbjct: 925  H---------EMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLEKVT 975

Query: 157  INTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQ 216
                 +K  +   + +     +  +   + E    + T      L E   + +NL  +  
Sbjct: 976  AEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTN-----LAEEEEKAKNLTKLKN 1030

Query: 217  SQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRD-NVEMIKLHKQL 275
                 I ELE    + K +  R+E E    L +  E  A+D    I D   ++ +L  QL
Sbjct: 1031 KHESMISELE--VRLKKEEKSRQELE---KLKRKLEGDASDFHEQIADLQAQIAELKMQL 1085

Query: 276  VEKSNALSAMEGKF-IQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSM 334
             +K   L A   +   ++ +K   L+   + L  +  +L   L  +R      EKQ   +
Sbjct: 1086 AKKEEELQAALARLDDEIAQKNNALKKIRE-LEGHISDLQEDLDSERAARNKAEKQKRDL 1144

Query: 335  -KFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLE 393
             +  E    EL+D ++    ++EL  +   ++  +    A +E+ +  E Q++ ++ Q  
Sbjct: 1145 GEELEALKTELEDTLDSTATQQELRAKREQEV--TVLKKALDEETRSHEAQVQ-EMRQKH 1201

Query: 394  TALKSDLTDKTEILDRLKTERDQNEK-LVQENREL--QLQYLEQ-KQQLDELKKRIKLYN 449
                 +LT++ E   R K   D+N++ L +EN +L  +L+ L Q KQ+++  KK+++   
Sbjct: 1202 AQAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQV 1261

Query: 450  QENDINAD-------ELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATH 502
            QE             EL++ +  ++ + E   G L+       ++ KD+     +LQ T 
Sbjct: 1262 QELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQ 1321

Query: 503  AETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARI 562
             E +Q  E+TR  L +  K+    Q+E E   R     Q D E++ +Q +         I
Sbjct: 1322 -ELLQ--EETRQKLNVSTKLR---QLEEE---RNSLQDQLDEEMEAKQNLE------RHI 1366

Query: 563  HKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIH-LERGENLFEIHINKVTFSSEVL 621
              L  QL D                   + +F  T+  LE G+  F+  I  +T   E  
Sbjct: 1367 STLNIQLSD---------------SKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEK 1411

Query: 622  QASGDK 627
             A+ DK
Sbjct: 1412 AAAYDK 1417



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 125/557 (22%), Positives = 229/557 (41%), Gaps = 79/557 (14%)

Query: 48   EELEDRFLRLHDENILLKQHARKQEDKIKRM--ATKLIRLVNDKKRYERVGGGPKRLGRD 105
            EELE     L D    L   A +QE + KR    T L + ++++ R         R    
Sbjct: 1146 EELEALKTELEDT---LDSTATQQELRAKREQEVTVLKKALDEETRSHEAQVQEMRQKHA 1202

Query: 106  VEMEEMIEQLQEKVH---ELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRR 162
              +EE+ EQL++       L+K  +TL+        +L+  G         Q++     +
Sbjct: 1203 QAVEELTEQLEQFKRAKANLDKNKQTLEKENADLAGELRVLG---------QAKQEVEHK 1253

Query: 163  KANENAGLQECPRKGIKFQDA--DVAETPHPMFTKYGN--SLLEEARGEIRNLENVIQSQ 218
            K    A +QE   K    + A  ++ +  H +  +  +   +L EA G+   L   + S 
Sbjct: 1254 KKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASL 1313

Query: 219  RGQIEELEHLAEILKTQLRRKENEIELSLLQLRE-----QQATDQRSNIRDNVEM----- 268
              Q+++ +   E+L+ + R+K N +   L QL E     Q   D+    + N+E      
Sbjct: 1314 SSQLQDTQ---ELLQEETRQKLN-VSTKLRQLEEERNSLQDQLDEEMEAKQNLERHISTL 1369

Query: 269  -IKLH---KQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKC 324
             I+L    K+L + ++ + A+E    + Q++   L   ++   A  D+L       + + 
Sbjct: 1370 NIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQEL 1429

Query: 325  CSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWK----- 379
              L   L + +     +E+ Q + + L  E + +   Y    D A + A E++ K     
Sbjct: 1430 DDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLA 1489

Query: 380  --LKEQ-QLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQ 436
              L+E  + K ++ +    LK+++ D     D +     + EK     R L+ Q  E K 
Sbjct: 1490 RALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEK---SKRALETQMEEMKT 1546

Query: 437  QLDELKKRIKLYNQENDINADELSEALLLIKAQ--KEQKNGDLSFLVKVDSEINKDLERS 494
            QL+EL         E+++ A E ++  L +  Q  K Q   DL    + + E  + L+R 
Sbjct: 1547 QLEEL---------EDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQ 1597

Query: 495  MRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHL 554
            + E +        ELE  R    +             A  +K+E   +D EL+ +  +  
Sbjct: 1598 LHEYET-------ELEDERKQRAL-----------AAAAKKKLEGDLKDLELQADSAIKG 1639

Query: 555  LDIRAARIHKLEAQLKD 571
             +    ++ KL+AQ+KD
Sbjct: 1640 REEAIKQLRKLQAQMKD 1656



 Score = 74.3 bits (181), Expect = 7e-13
 Identities = 127/624 (20%), Positives = 256/624 (41%), Gaps = 61/624 (9%)

Query: 28   QETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVN 87
            +E +  + ++  +  +    ++LED  L + D+N  L +  +  E++I  + T L     
Sbjct: 961  EEEAARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEERISDLTTNLAEEEE 1020

Query: 88   DKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQ 147
              K   ++    K      E+E  +++ ++   ELEK    L+       +Q+       
Sbjct: 1021 KAKNLTKLKN--KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIA------ 1072

Query: 148  TPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGE 207
                ++Q++I   + +    A  +E  +  +   D ++A+  + +        + E  G 
Sbjct: 1073 ----DLQAQIAELKMQL---AKKEEELQAALARLDDEIAQKNNAL------KKIRELEGH 1119

Query: 208  IRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVE 267
            I +L+  + S+R    + E     L  +L   + E+E +L    +  AT Q    +   E
Sbjct: 1120 ISDLQEDLDSERAARNKAEKQKRDLGEELEALKTELEDTL----DSTATQQELRAKREQE 1175

Query: 268  MIKLHKQLVEKSNALSA----MEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQ--- 320
            +  L K L E++ +  A    M  K  Q  E+            AN D+    L+++   
Sbjct: 1176 VTVLKKALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANLDKNKQTLEKENAD 1235

Query: 321  ---RLKCCSLEKQ--LHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHE 375
                L+     KQ   H  K  E +++ELQ + +D E+ R  L +   KL +   S    
Sbjct: 1236 LAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAELNDKVHKLQNEVESVT-- 1293

Query: 376  EQWKLKEQQLK-VQIAQLETALKSDLTDKTEILDRLKTERDQN-----EKLVQENRELQL 429
                L E + K +++A+   +L S L D  E+L   +T +  N      +L +E   LQ 
Sbjct: 1294 --GMLNEAEGKAIKLAKDVASLSSQLQDTQELLQE-ETRQKLNVSTKLRQLEEERNSLQD 1350

Query: 430  QYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKN------GDLSFLVKV 483
            Q  E+ +    L++ I   N +   +  +L +    ++A +E K        +L+   + 
Sbjct: 1351 QLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKEIENLTQQYEE 1410

Query: 484  DSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQM---EVEAVTRKMENL 540
             +     LE++   LQ    + V +L+  R ++    K  + +     E + ++ K  + 
Sbjct: 1411 KAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADE 1470

Query: 541  QQDYELKV-EQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIH 599
            +   E +  E+    L +  A    LEA+ +++    K  K + E +   S D+  + +H
Sbjct: 1471 RDRAEAEAREKETKALSLARALEEALEAK-EELERTNKMLKAEMEDLV-SSKDDVGKNVH 1528

Query: 600  -LERGENLFEIHINKVTFSSEVLQ 622
             LE+ +   E  + ++    E L+
Sbjct: 1529 ELEKSKRALETQMEEMKTQLEELE 1552



 Score = 70.9 bits (172), Expect = 7e-12
 Identities = 121/601 (20%), Positives = 252/601 (41%), Gaps = 102/601 (16%)

Query: 27   LQETSTTRTMKSRQAVSRVSR-EELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRL 85
            LQ+T      ++RQ ++  ++  +LE+    L D+   L +    +++  + ++T  I+L
Sbjct: 1317 LQDTQELLQEETRQKLNVSTKLRQLEEERNSLQDQ---LDEEMEAKQNLERHISTLNIQL 1373

Query: 86   VNDKKRY-------ERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQ 138
             + KK+        E +  G KR  +  E+E + +Q +EK    +K  +T KNRL     
Sbjct: 1374 SDSKKKLQDFASTVEALEEGKKRFQK--EIENLTQQYEEKAAAYDKLEKT-KNRLQQELD 1430

Query: 139  QL--QTQGYRQTPYN----------------NVQSRINTGRRKANENAGLQECPRKGIK- 179
             L       RQ   N                N+ S+    R +A   A  +E     +  
Sbjct: 1431 DLVVDLDNQRQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLAR 1490

Query: 180  -----FQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRG---QIEELEHLAEI 231
                  +  +  E  + M       L+       +N+  + +S+R    Q+EE++   E 
Sbjct: 1491 ALEEALEAKEELERTNKMLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEE 1550

Query: 232  LKTQLRRKEN---EIELSL----------LQLREQQATDQRSNIRDNVEMIKLHKQLVEK 278
            L+ +L+  E+    +E+++          LQ R++Q  ++R  ++  +   +   +   K
Sbjct: 1551 LEDELQATEDAKLRLEVNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERK 1610

Query: 279  SNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFS- 337
              AL+A   K  +L+   + L +  D+ +   +E   QL++ + +    +++L   + S 
Sbjct: 1611 QRALAAAAKK--KLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASR 1668

Query: 338  ----------ERRIEELQDRINDLE----------KERELLKENYDKLYDSAFSAAHEEQ 377
                      E++ + L+  +  L+          K+ +L KE   +   S+ S  +  Q
Sbjct: 1669 DEIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQ 1728

Query: 378  WKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQE---NRELQLQYLEQ 434
             +  +++L+ +IAQLE  L+ +  +   + DR++    Q E+L  E    R    +    
Sbjct: 1729 DE--KRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESA 1786

Query: 435  KQQLDELKK--RIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLE 492
            +QQL+   K  R KL+  E                A K +    ++ L    +++ + +E
Sbjct: 1787 RQQLERQNKELRSKLHEMEG---------------AVKSKFKSTIAALEAKIAQLEEQVE 1831

Query: 493  RSMRELQATHAETVQELEKTRNMLIM---QHKINKDYQMEVEAVTRKMENLQQDYELKVE 549
            +  RE QA      Q+ +K + +L+    + K+ + Y+ + E    +++ L++  E   E
Sbjct: 1832 QEAREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEE 1891

Query: 550  Q 550
            +
Sbjct: 1892 E 1892



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 80/386 (20%), Positives = 177/386 (45%), Gaps = 45/386 (11%)

Query: 214  VIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEM----- 268
            ++Q  R + E      E+ KT+ R+++ E EL  L+ +  Q T++++ +++ ++      
Sbjct: 844  LLQVTRQEEEMQAKEDELQKTKERQQKAENELKELEQKHSQLTEEKNLLQEQLQAETELY 903

Query: 269  -------IKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQR 321
                   ++L  +  E    L  ME +  + +++ + L+     +     +L  QL+E+ 
Sbjct: 904  AEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRGQQLQAERKKMAQQMLDLEEQLEEEE 963

Query: 322  LKCCSLEKQLHSMKFSERRIEE----LQDRINDLEKERELLKENYDKLYDSAFSAAHEEQ 377
                 L+ +  + +   +++E+    + D+ N L KER+LL+E   ++ D   + A EE+
Sbjct: 964  AARQKLQLEKVTAEAKIKKLEDEILVMDDQNNKLSKERKLLEE---RISDLTTNLAEEEE 1020

Query: 378  WKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQ 437
             K K       + +L+   +S ++   E+  RLK E    ++L +  R+L+    +  +Q
Sbjct: 1021 -KAKN------LTKLKNKHESMIS---ELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQ 1070

Query: 438  LDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVD---SEINKDL--- 491
            + +L+ +I     +     +EL  AL  +  +  QKN  L  + +++   S++ +DL   
Sbjct: 1071 IADLQAQIAELKMQLAKKEEELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSE 1130

Query: 492  -------ERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDY 544
                   E+  R+L         ELE T +    Q ++    + EV  + + ++   + +
Sbjct: 1131 RAARNKAEKQKRDLGEELEALKTELEDTLDSTATQQELRAKREQEVTVLKKALDEETRSH 1190

Query: 545  ELKVEQYVHLLDIRAARIHKLEAQLK 570
            E +V++   +    A  + +L  QL+
Sbjct: 1191 EAQVQE---MRQKHAQAVEELTEQLE 1213



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 102/489 (20%), Positives = 206/489 (42%), Gaps = 83/489 (16%)

Query: 39   RQAVSRVSREELEDRFLRLHDENILLKQ---------HARKQEDKIKRMATKLIRLVNDK 89
            RQ VS + +++ +   L   ++NI  K           AR++E K   +A  L   +  K
Sbjct: 1440 RQLVSNLEKKQRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALEAK 1499

Query: 90   KRYERVGGGPKRLGRDVEMEEMI---EQLQEKVHELEKQNETLKNRLISAKQQLQT--QG 144
            +  ER     K      EME+++   + + + VHELEK    L+ ++   K QL+     
Sbjct: 1500 EELERTNKMLK-----AEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDE 1554

Query: 145  YRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEA 204
             + T    ++  +N    K      LQ         Q+ +          +Y   L +E 
Sbjct: 1555 LQATEDAKLRLEVNMQALKGQFERDLQARDE-----QNEEKRRQLQRQLHEYETELEDER 1609

Query: 205  R-------------GEIRNLE----NVIQSQRGQIEELEHLAEILKTQLRR--------- 238
            +             G++++LE    + I+ +   I++L  L   +K   R          
Sbjct: 1610 KQRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRD 1669

Query: 239  ------KENE-----IELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEG 287
                  KENE     +E  L+QL+E  A  +R+  + ++E  +L ++L    +  +A++ 
Sbjct: 1670 EIFATAKENEKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD 1729

Query: 288  KFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDR 347
            +  +L+ +   L    +    N + ++ ++++   +   L  +L + + + ++ E  + +
Sbjct: 1730 EKRRLEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ 1789

Query: 348  INDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEIL 407
               LE++    KE   KL++     A + ++K     L+ +IAQLE  ++ +  +K    
Sbjct: 1790 ---LERQN---KELRSKLHE--MEGAVKSKFKSTIAALEAKIAQLEEQVEQEAREKQAAT 1841

Query: 408  DRLKTERDQNEKL---VQENRELQLQYLEQ-----------KQQLDELKKRIKLYNQEND 453
              LK +  + +++   V++ R++  QY EQ           K+QL+E ++  +  N    
Sbjct: 1842 KSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEESQRINANRR 1901

Query: 454  INADELSEA 462
                EL EA
Sbjct: 1902 KLQRELDEA 1910


>gi|31982906 cingulin-like 1 [Homo sapiens]
          Length = 1302

 Score = 80.5 bits (197), Expect = 9e-15
 Identities = 108/549 (19%), Positives = 243/549 (44%), Gaps = 57/549 (10%)

Query: 29   ETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVND 88
            E    + +K  +   R + EEL  +     +EN  L+Q   + E ++++   +L ++  +
Sbjct: 633  EVKNQQNIKEERERMRANLEELRSQHNEKVEENSTLQQRLEESEGELRKNLEELFQVKME 692

Query: 89   KKRYERVGGGPKRLGRDV--EMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYR 146
            +++++          RD+  ++ EM ++L       +++   L   L+ AKQ LQ     
Sbjct: 693  REQHQTE-------IRDLQDQLSEMHDELDSAKRSEDREKGALIEELLQAKQDLQDLLIA 745

Query: 147  QTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARG 206
            +    ++       R++  E   L+   ++ +   D ++ +     +     +L E    
Sbjct: 746  KEEQEDLL------RKRERELTALKGALKEEVSSHDQEMDKLKE-QYDAELQALRESVEE 798

Query: 207  EIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNV 266
              +N+E  + + R    E +     ++ +L ++ENE     LQ R ++   + + ++  +
Sbjct: 799  ATKNVE--VLASRSNTSEQDQAGTEMRVKLLQEENE----KLQGRSEELERRVAQLQRQI 852

Query: 267  EMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCS 326
            E +K  +   +    L   EG+  QL+E          AL+    E    +  +R    +
Sbjct: 853  EDLKGDE--AKAKETLKKYEGEIRQLEE----------ALVHARKEEKEAVSARR----A 896

Query: 327  LEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLK 386
            LE +L + + +  +  + Q ++++  KE    KE   +L +        E+W L +   K
Sbjct: 897  LENELEAAQGNLSQTTQEQKQLSEKLKEESEQKEQLRRLKNE----MENERWHLGKTIEK 952

Query: 387  VQIAQLETALKSDLTDKTEILDRLKTERDQNEK-LVQENRELQLQYLE-QKQQLDELKKR 444
            +Q  ++   +++  T   E+ ++L   +++N + L +  R+L+ + LE +K +L  +K +
Sbjct: 953  LQ-KEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEKSRLTAMKMQ 1011

Query: 445  IKLYNQENDINADELSEALLLIKAQ-KEQKNGDLSFLVKVDSEINKDLERSMRELQATHA 503
             ++   E ++   + ++   L K Q  EQ   DL + ++  S +  D  R +++++   +
Sbjct: 1012 DEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRLVKQMEDKVS 1071

Query: 504  ETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIH 563
            +   ELE+ RN        N D  +  E ++R  E ++Q     +++     D+   +I 
Sbjct: 1072 QLEMELEEERN--------NSD--LLSERISRSREQMEQLRNELLQERAARQDLECDKI- 1120

Query: 564  KLEAQLKDI 572
             LE Q KD+
Sbjct: 1121 SLERQNKDL 1129



 Score = 75.9 bits (185), Expect = 2e-13
 Identities = 115/584 (19%), Positives = 244/584 (41%), Gaps = 82/584 (14%)

Query: 47   REELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDV 106
            RE +E+    +  E +  + +  +Q+     M  KL++  N+K +           GR  
Sbjct: 793  RESVEEATKNV--EVLASRSNTSEQDQAGTEMRVKLLQEENEKLQ-----------GRSE 839

Query: 107  EMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANE 166
            E+E  + QLQ ++ +L+      K  L   + +++           ++  +   R++  E
Sbjct: 840  ELERRVAQLQRQIEDLKGDEAKAKETLKKYEGEIR----------QLEEALVHARKEEKE 889

Query: 167  NAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEA--RGEIRNLENVIQSQRGQIEE 224
                +      ++    ++++T      +    L EE+  + ++R L+N ++++R     
Sbjct: 890  AVSARRALENELEAAQGNLSQTTQEQ-KQLSEKLKEESEQKEQLRRLKNEMENERW---- 944

Query: 225  LEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSA 284
              HL + ++   +   + +E S     E Q        ++  E+ ++ +QL EK+     
Sbjct: 945  --HLGKTIEKLQKEMADIVEASRTSTLELQNQLDEYKEKNRRELAEMQRQLKEKTLEAEK 1002

Query: 285  MEGKFIQLQEKQRTLRIS-HDALMANGDELNM-QLKEQRLKCCS--LEKQLHSMKFSERR 340
                 +++Q++ R +     D   A  + L   QL EQ LK     LE + H      R 
Sbjct: 1003 SRLTAMKMQDEMRLMEEELRDYQRAQDEALTKRQLLEQTLKDLEYELEAKSHLKDDRSRL 1062

Query: 341  IEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDL 400
            +++++D+++ LE E E  + N D L     S + E+  +L+ + L+      E A + DL
Sbjct: 1063 VKQMEDKVSQLEMELEEERNNSD-LLSERISRSREQMEQLRNELLQ------ERAARQDL 1115

Query: 401  TDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELS 460
                   D++  ER QN+ L      L+  Y   K+ L  ++   ++   E+ + ++E  
Sbjct: 1116 E-----CDKISLER-QNKDLKSRIIHLEGSYRSSKEGL-VVQMEARIAELEDRLESEERD 1168

Query: 461  EALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQH 520
             A L +                     N+ LER ++EL     +    L   ++ L ++ 
Sbjct: 1169 RANLQLS--------------------NRRLERKVKELVMQVDDEHLSLTDQKDQLSLRL 1208

Query: 521  KINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYK 580
            K  K    E E    ++E+ ++  + ++E+ + + +    +++ ++  L+         K
Sbjct: 1209 KAMKRQVEEAEEEIDRLESSKKKLQRELEEQMDMNEHLQGQLNSMKKDLR--------LK 1260

Query: 581  FKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSEVLQAS 624
              P  + DD  D+ D +     G +L+E  ++  TFS +   AS
Sbjct: 1261 KLPSKVLDDMDDDDDLSTD---GGSLYEAPVS-YTFSKDSTVAS 1300



 Score = 62.8 bits (151), Expect = 2e-09
 Identities = 120/580 (20%), Positives = 234/580 (40%), Gaps = 132/580 (22%)

Query: 31  STTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKK 90
           +T   +K +Q +++ + EE   + L  +     LK+ +   +D  KR    +   +   K
Sbjct: 535 ATPDLLKGQQELTQQTNEETAKQILYNY-----LKEGSTDNDDATKRKVNLVFEKIQTLK 589

Query: 91  RYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRL-ISAKQQLQTQGYRQTP 149
              R  G  +   +       ++ L E+  +L  +   L+ +L +  K Q   +  R+  
Sbjct: 590 --SRAAGSAQGNNQACNSTSEVKDLLEQKSKLTIEVAELQRQLQLEVKNQQNIKEERERM 647

Query: 150 YNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIR 209
             N++   +    K  EN+ LQ+                            LEE+ GE+R
Sbjct: 648 RANLEELRSQHNEKVEENSTLQQ---------------------------RLEESEGELR 680

Query: 210 NLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMI 269
                           ++L E+ + ++ R++++ E+  LQ       DQ S + D ++  
Sbjct: 681 ----------------KNLEELFQVKMEREQHQTEIRDLQ-------DQLSEMHDELDSA 717

Query: 270 KLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEK 329
           K  +   EK   +  +      LQ KQ       D L+A  ++ ++  K +R        
Sbjct: 718 KRSEDR-EKGALIEEL------LQAKQDL----QDLLIAKEEQEDLLRKRER-------- 758

Query: 330 QLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQI 389
           +L ++K +      L++ ++  ++E + LKE YD    +   A  E    ++E    V++
Sbjct: 759 ELTALKGA------LKEEVSSHDQEMDKLKEQYD----AELQALRES---VEEATKNVEV 805

Query: 390 AQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQL-----DELKKR 444
               +         TE+  R+K  +++NEKL   + EL+ +  + ++Q+     DE K +
Sbjct: 806 LASRSNTSEQDQAGTEM--RVKLLQEENEKLQGRSEELERRVAQLQRQIEDLKGDEAKAK 863

Query: 445 IKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAE 504
             L   E +I   +L EA  L+ A+KE+K       V     +  +LE +   L  T  E
Sbjct: 864 ETLKKYEGEIR--QLEEA--LVHARKEEKEA-----VSARRALENELEAAQGNLSQTTQE 914

Query: 505 TVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHK 564
             Q  EK +             + E +   R+++N     E++ E++ HL       I K
Sbjct: 915 QKQLSEKLKE------------ESEQKEQLRRLKN-----EMENERW-HL----GKTIEK 952

Query: 565 LEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGE 604
           L+ ++ DI   ++    + +    + +DE+ E    E  E
Sbjct: 953 LQKEMADIVEASRTSTLELQ----NQLDEYKEKNRRELAE 988


>gi|38045896 RAB6-interacting protein 2 isoform delta [Homo sapiens]
          Length = 1088

 Score = 80.1 bits (196), Expect = 1e-14
 Identities = 123/601 (20%), Positives = 254/601 (42%), Gaps = 107/601 (17%)

Query: 39  RQAVSRVSREELEDRFLRLHDENILLKQHA-RKQEDKIKRMATKLIRLVNDKK--RYERV 95
           R A + +    LE    +   EN +L++   R+ E+      TK ++ V + K  +   +
Sbjct: 335 RLAEAEMHVHHLESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSM 394

Query: 96  GGGPKRLGRDVEMEEM-----IEQLQEKVHELE---KQNETLKNRLISAKQQLQTQGYRQ 147
             G + L  +++M +       E+ +E++ ++E     ++ +KN++   KQ+L     + 
Sbjct: 395 ERGLRDLEEEIQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSR---KD 451

Query: 148 TPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVA----------------ETPHP 191
           T    +Q+++ T   + +++    E  ++ +  ++   A                ET   
Sbjct: 452 TELLALQTKLETLTNQFSDSKQHIEVLKESLTAKEQRAAILQTEVDALRLRLEEKETMLN 511

Query: 192 MFTKYGNSLLEEA---RGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEI----- 243
             TK    + EE     GEI +L++++  +  ++  L+   E L+ QLR KE ++     
Sbjct: 512 KKTKQIQDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKE 571

Query: 244 --------------------------ELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVE 277
                                     E ++ +L+EQ+  D+R    +     K  K L E
Sbjct: 572 RVKSLQADTTNTDTALTTLEEALAEKERTIERLKEQRDRDEREKQEEIDNYKKDLKDLKE 631

Query: 278 KSNAL----SAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQL-- 331
           K + L    S  E   + L+E   +L  S     +    L + L++++ +C  +E QL  
Sbjct: 632 KVSLLQGDLSEKEASLLDLKEHASSLASSGLKKDSRLKTLEIALEQKKEECLKMESQLKK 691

Query: 332 -HSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIA 390
            H      R   E+ DRI  LE+E    K+   K        A  E  +L E   +V+  
Sbjct: 692 AHEAALEARASPEMSDRIQHLEREITRYKDESSK--------AQAEVDRLLEILKEVE-- 741

Query: 391 QLETALKSDLTDKTEILDRLKTE-RDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYN 449
                  ++  DK + +  L+ + +DQN+K+     + Q++  +  Q L+E ++R     
Sbjct: 742 -------NEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQMLEEARRR----- 789

Query: 450 QENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQEL 509
              + N ++ S+ L     +K+ +  +L   ++   +I  + E  + + ++      +++
Sbjct: 790 ---EDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTNAEKQV 846

Query: 510 EKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQL 569
           E+   +L+   K+    + E+E++  K+ + QQ      E+  HL ++RA R   LE  L
Sbjct: 847 EE---LLMAMEKV----KQELESMKAKLSSTQQSL---AEKETHLTNLRAERRKHLEEVL 896

Query: 570 K 570
           +
Sbjct: 897 E 897



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 98/547 (17%), Positives = 218/547 (39%), Gaps = 60/547 (10%)

Query: 1   MSGPTDETAGDLPVKDTGLNLFGMGGLQETSTTRTMKSRQAVSRVSREEL---EDRFLRL 57
           M     +   +L  KDT   L  +    ET T +   S+Q +  V +E L   E R   L
Sbjct: 436 MKNKIGQVKQELSRKDT--ELLALQTKLETLTNQFSDSKQHIE-VLKESLTAKEQRAAIL 492

Query: 58  HDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQE 117
             E   L+    ++E  + +   ++  +  +K           + G   ++++M++  + 
Sbjct: 493 QTEVDALRLRLEEKETMLNKKTKQIQDMAEEKGT---------QAGEIHDLKDMLDVKER 543

Query: 118 KVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKG 177
           KV+ L+K+ E L+ +L   ++Q+ +   R        +  +T      E    +E   + 
Sbjct: 544 KVNVLQKKIENLQEQLRDKEKQMSSLKERVKSLQADTTNTDTALTTLEEALAEKERTIER 603

Query: 178 IKFQ-DADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEEL-EHLAEILKTQ 235
           +K Q D D  E    +   Y   L ++ + ++  L+  +  +   + +L EH + +  + 
Sbjct: 604 LKEQRDRDEREKQEEI-DNYKKDL-KDLKEKVSLLQGDLSEKEASLLDLKEHASSLASSG 661

Query: 236 LRRKENEIELSL-LQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQE 294
           L++      L + L+ ++++     S ++   E     +   E S+ +  +E +  + ++
Sbjct: 662 LKKDSRLKTLEIALEQKKEECLKMESQLKKAHEAALEARASPEMSDRIQHLEREITRYKD 721

Query: 295 KQ--------RTLRISHDALMANGD------ELNMQLKEQRLKCCSLE-KQLHSMKFSER 339
           +         R L I  +      D      EL  Q+K+Q  K  +L+ K+    K S +
Sbjct: 722 ESSKAQAEVDRLLEILKEVENEKNDKDKKIAELERQVKDQNKKVANLKHKEQVEKKKSAQ 781

Query: 340 RIEEL---QDRIND---------------LEKERELLKENYDKLYDSAFSAAHEEQWKLK 381
            +EE    +D +ND               +E+  E L+E+     +     A EE  +  
Sbjct: 782 MLEEARRREDNLNDSSQQLQDSLRKKDDRIEELEEALRESVQITAEREMVLAQEESARTN 841

Query: 382 EQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDEL 441
            ++   ++      +K +L      L   +    + E  +   R  + ++LE  + L+  
Sbjct: 842 AEKQVEELLMAMEKVKQELESMKAKLSSTQQSLAEKETHLTNLRAERRKHLE--EVLEMK 899

Query: 442 KKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQAT 501
           ++ +     E D N      ALL + + K++   +++ L +    + + L++  +     
Sbjct: 900 QEALLAAISEKDANI-----ALLELSSSKKKTQEEVAALKREKDRLVQQLKQQTQNRMKL 954

Query: 502 HAETVQE 508
            A+  ++
Sbjct: 955 MADNYED 961



 Score = 41.6 bits (96), Expect = 0.005
 Identities = 82/427 (19%), Positives = 178/427 (41%), Gaps = 74/427 (17%)

Query: 175 RKGIKFQDADVAETPHPMFTKYGNSLLEEA---RGEIRNLENVIQSQRGQIEELEHLAEI 231
           RK ++ +++ ++ + + + T +   L +E    + E   +    +  R   EE +H+   
Sbjct: 169 RKDVEVKESKLSSSMNSIKTFWSPELKKERALRKDEASKITIWKEQYRVVQEENQHMQ-- 226

Query: 232 LKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQ 291
           +  Q  + E  I+  L QL +Q ++  R+      E+ + + Q +   +   A E   ++
Sbjct: 227 MTIQALQDELRIQRDLNQLFQQDSSS-RTGEPCVAELTEENFQRLHAEHERQAKELFLLR 285

Query: 292 --LQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLE------KQLHSMKFSERRIEE 343
             L+E +  +      L A  + +   L+  + K  S +      ++   +  +E  +  
Sbjct: 286 KTLEEMELRIETQKQTLNARDESIKKLLEMLQSKGLSAKATEEDHERTRRLAEAEMHVHH 345

Query: 344 LQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDK 403
           L+  +   EKE  +L+E   + +++A  +A  +  +   +    +I+ +E  L+ DL ++
Sbjct: 346 LESLLEQKEKENSMLREEMHRRFENAPDSAKTKALQTVIEMKDSKISSMERGLR-DLEEE 404

Query: 404 TEIL---DRLKTERDQNE----------------KLVQENRELQL--------------- 429
            ++L     L TE  + E                K+ Q  +EL                 
Sbjct: 405 IQMLKSNGALSTEEREEEMKQMEVYRSHSKFMKNKIGQVKQELSRKDTELLALQTKLETL 464

Query: 430 --QYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEI 487
             Q+ + KQ ++ LK+ +    Q   I   E+ +AL L   +KE      + L K   +I
Sbjct: 465 TNQFSDSKQHIEVLKESLTAKEQRAAILQTEV-DALRLRLEEKE------TMLNKKTKQI 517

Query: 488 NKDLERSMRELQATHAETVQELE-----KTRNMLIMQHKIN------KDYQMEVEAVTRK 536
                + M E + T A  + +L+     K R + ++Q KI       +D + ++ ++  +
Sbjct: 518 -----QDMAEEKGTQAGEIHDLKDMLDVKERKVNVLQKKIENLQEQLRDKEKQMSSLKER 572

Query: 537 MENLQQD 543
           +++LQ D
Sbjct: 573 VKSLQAD 579


>gi|12667788 myosin, heavy polypeptide 9, non-muscle [Homo sapiens]
          Length = 1960

 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 119/562 (21%), Positives = 229/562 (40%), Gaps = 69/562 (12%)

Query: 28   QETSTTRTMKSRQAVSRVSREELEDRFLRLHDENIL---LKQHARKQEDKIKRMATKLIR 84
            +E    +T       S  +++EL  +  R  + NIL   L++ A+  E +I+ M  K  +
Sbjct: 1139 EELEALKTELEDTLDSTAAQQELRSK--REQEVNILKKTLEEEAKTHEAQIQEMRQKHSQ 1196

Query: 85   LVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNR----LISAKQQL 140
             V                    E+ E +EQ +     LEK  +TL+N         K  L
Sbjct: 1197 AVE-------------------ELAEQLEQTKRVKANLEKAKQTLENERGELANEVKVLL 1237

Query: 141  QTQGYRQTPYNNVQSRINTGRRKANENAGLQ-ECPRKGIKFQDADVAETPHPMFTKYGNS 199
            Q +G  +     V++++   + K NE   ++ E   K  K Q   V            +S
Sbjct: 1238 QGKGDSEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKLQ---VELDNVTGLLSQSDS 1294

Query: 200  LLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQR 259
               +   +   LE+ +Q  +  ++E       L T+L++ E+E      QL E++  + +
Sbjct: 1295 KSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEKNSFREQLEEEE--EAK 1352

Query: 260  SNIRDNV-----EMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELN 314
             N+   +     ++  + K++ +    L   E    +LQ+    L   H+  +A  D+L 
Sbjct: 1353 HNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLSQRHEEKVAAYDKLE 1412

Query: 315  MQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAH 374
                  + +   L   L   + S   +E+ Q + + L  E + +   Y +  D A + A 
Sbjct: 1413 KTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAR 1472

Query: 375  EEQWKLKE-----QQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQL 429
            E++ K        ++   Q A+LE   K     +TE+ D + ++ D  + +     EL+ 
Sbjct: 1473 EKETKALSLARALEEAMEQKAELERLNKQF---RTEMEDLMSSKDDVGKSV----HELEK 1525

Query: 430  QYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINK 489
                 +QQ++E+K +++    E     D      + ++A K Q   DL    +   E  K
Sbjct: 1526 SKRALEQQVEEMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKK 1585

Query: 490  DLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVE 549
             L R +RE++A       ELE  R    M     K  +M+++ +   +++  ++ +  ++
Sbjct: 1586 QLVRQVREMEA-------ELEDERKQRSMAVAARKKLEMDLKDLEAHIDSANKNRDEAIK 1638

Query: 550  QYVHLLDIRAARIHKLEAQLKD 571
            Q           + KL+AQ+KD
Sbjct: 1639 Q-----------LRKLQAQMKD 1649



 Score = 79.3 bits (194), Expect = 2e-14
 Identities = 99/454 (21%), Positives = 202/454 (44%), Gaps = 56/454 (12%)

Query: 192  MFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLR 251
            +FTK    LL+ +R E   +    + +  ++ E +  AE   T++   ++++    LQL+
Sbjct: 830  LFTKV-KPLLQVSRQEEEMMAK--EEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQ 886

Query: 252  EQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGD 311
            EQ   +            +L  +  E       +E +  + +E+ + L+     +  N  
Sbjct: 887  EQLQAETELCAEAEELRARLTAKKQELEEICHDLEARVEEEEERCQHLQAEKKKMQQNIQ 946

Query: 312  ELNMQLKEQRLKCCSLEKQLHSMKFSERRIEE----LQDRINDLEKERELLKENYDKLYD 367
            EL  QL+E+      L+ +  + +   +++EE    L+D+   L KE++LL+   D++ +
Sbjct: 947  ELEEQLEEEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLE---DRIAE 1003

Query: 368  SAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENREL 427
               +   EE+   K + L    A+L+   ++ +TD  E   RL+ E  Q ++L +  R+L
Sbjct: 1004 FTTNLTEEEE---KSKSL----AKLKNKHEAMITDLEE---RLRREEKQRQELEKTRRKL 1053

Query: 428  QLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVD--- 484
            +    +   Q+ EL+ +I     +     +EL  AL  ++ +  QKN  L  + +++   
Sbjct: 1054 EGDSTDLSDQIAELQAQIAELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQI 1113

Query: 485  SEINKDL----------ERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVT 534
            SE+ +DL          E+  R+L         ELE T +    Q ++    + EV  + 
Sbjct: 1114 SELQEDLESERASRNKAEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNILK 1173

Query: 535  RKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEF 594
            + +E   + +E ++++   +    +  + +L  QL+     TK+ K         ++++ 
Sbjct: 1174 KTLEEEAKTHEAQIQE---MRQKHSQAVEELAEQLEQ----TKRVK--------ANLEKA 1218

Query: 595  DETIHLERGENLFEIHINKVTFSSEVLQASGDKE 628
             +T+  ERGE   E+ +        +LQ  GD E
Sbjct: 1219 KQTLENERGELANEVKV--------LLQGKGDSE 1244



 Score = 74.3 bits (181), Expect = 7e-13
 Identities = 117/628 (18%), Positives = 254/628 (40%), Gaps = 69/628 (10%)

Query: 28   QETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVN 87
            +E S  + ++  +  +    ++LE+  + L D+N  L +  +  ED+I    T L     
Sbjct: 954  EEESARQKLQLEKVTTEAKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEE 1013

Query: 88   DKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQ---LQTQ- 143
              K   ++    K      ++EE + + +++  ELEK    L+        Q   LQ Q 
Sbjct: 1014 KSKSLAKLKN--KHEAMITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQIAELQAQI 1071

Query: 144  GYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEE 203
               +      +  +     +  E A  +    K I+  ++ ++E    + ++  +    +
Sbjct: 1072 AELKMQLAKKEEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASR--NK 1129

Query: 204  ARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIR 263
            A  + R+L   +++ + ++E+        +    ++E E+ + L +  E++A    + I+
Sbjct: 1130 AEKQKRDLGEELEALKTELEDTLDSTAAQQELRSKREQEVNI-LKKTLEEEAKTHEAQIQ 1188

Query: 264  DNVEMIKLHKQLVEK-SNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRL 322
               EM + H Q VE+ +  L   +     L++ ++TL      L AN  ++ +Q K    
Sbjct: 1189 ---EMRQKHSQAVEELAEQLEQTKRVKANLEKAKQTLENERGEL-ANEVKVLLQGKGD-- 1242

Query: 323  KCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKE 382
                     H  K  E +++ELQ + N+ E+ R  L +   KL                 
Sbjct: 1243 -------SEHKRKKVEAQLQELQVKFNEGERVRTELADKVTKL----------------- 1278

Query: 383  QQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELK 442
            Q     +  L +   S  +  T+    L+++    ++L+QE    +L    + +Q+++ K
Sbjct: 1279 QVELDNVTGLLSQSDSKSSKLTKDFSALESQLQDTQELLQEENRQKLSLSTKLKQVEDEK 1338

Query: 443  KRIKLYNQENDINADELSEALLLIKAQ---KEQKNGDLSFLVKVDSEINKDLERSMRELQ 499
               +   +E +     L + +  + AQ    ++K  D    ++   E+ + L++ +  L 
Sbjct: 1339 NSFREQLEEEEEAKHNLEKQIATLHAQVADMKKKMEDSVGCLETAEEVKRKLQKDLEGLS 1398

Query: 500  ATHAETV---QELEKTRNMLIMQHK---INKDYQME----VEAVTRKMENLQQDYELKVE 549
              H E V    +LEKT+  L  +     ++ D+Q +    +E   +K + L  + +    
Sbjct: 1399 QRHEEKVAAYDKLEKTKTRLQQELDDLLVDLDHQRQSACNLEKKQKKFDQLLAEEKTISA 1458

Query: 550  QYVHLLDIRAARIHKLEAQLKDIAYG--------------TKQYKFKPEIMPDDSVDEFD 595
            +Y    D   A   + E +   +A                 KQ++ + E +   S D+  
Sbjct: 1459 KYAEERDRAEAEAREKETKALSLARALEEAMEQKAELERLNKQFRTEMEDLM-SSKDDVG 1517

Query: 596  ETIH-LERGENLFEIHINKVTFSSEVLQ 622
            +++H LE+ +   E  + ++    E L+
Sbjct: 1518 KSVHELEKSKRALEQQVEEMKTQLEELE 1545



 Score = 72.4 bits (176), Expect = 3e-12
 Identities = 105/483 (21%), Positives = 196/483 (40%), Gaps = 89/483 (18%)

Query: 109  EEMIEQLQEKVHELEKQ---------NETLKNRLISAKQQLQTQGYRQTPYNNVQSRINT 159
            EEM+ + +E V   EKQ          ETL+++L++ K QLQ Q   +T           
Sbjct: 845  EEMMAKEEELVKVREKQLAAENRLTEMETLQSQLMAEKLQLQEQLQAET----------- 893

Query: 160  GRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQR 219
                       + C                          L      + + LE +     
Sbjct: 894  -----------ELCAE---------------------AEELRARLTAKKQELEEICHDLE 921

Query: 220  GQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKS 279
             ++EE E   + L+ + ++ +  I+    QL E+++  Q           KL  + V   
Sbjct: 922  ARVEEEEERCQHLQAEKKKMQQNIQELEEQLEEEESARQ-----------KLQLEKVTTE 970

Query: 280  NALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSER 339
              L  +E + I L+++   L      L     E    L E+  K  SL K  +     E 
Sbjct: 971  AKLKKLEEEQIILEDQNCKLAKEKKLLEDRIAEFTTNLTEEEEKSKSLAKLKNK---HEA 1027

Query: 340  RIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSD 399
             I +L++R+   EK+R+ L++   KL   +   + +        +L+ QIA+L+  L   
Sbjct: 1028 MITDLEERLRREEKQRQELEKTRRKLEGDSTDLSDQ------IAELQAQIAELKMQLAKK 1081

Query: 400  LTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLD-ELKKRIKLYNQENDINAD- 457
              +    L R++ E  Q    +++ REL+ Q  E ++ L+ E   R K   Q+ D+  + 
Sbjct: 1082 EEELQAALARVEEEAAQKNMALKKIRELESQISELQEDLESERASRNKAEKQKRDLGEEL 1141

Query: 458  -----ELSEALLLIKAQKE---QKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQEL 509
                 EL + L    AQ+E   ++  +++ L K   E  K  E  ++E++  H++ V+EL
Sbjct: 1142 EALKTELEDTLDSTAAQQELRSKREQEVNILKKTLEEEAKTHEAQIQEMRQKHSQAVEEL 1201

Query: 510  EKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQL 569
             +       Q +  K  +  +E   + +EN + +   +V+  +        +  K+EAQL
Sbjct: 1202 AE-------QLEQTKRVKANLEKAKQTLENERGELANEVKVLLQGKGDSEHKRKKVEAQL 1254

Query: 570  KDI 572
            +++
Sbjct: 1255 QEL 1257



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 129/623 (20%), Positives = 270/623 (43%), Gaps = 108/623 (17%)

Query: 27   LQETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKI----KRMATKL 82
            LQ+T      ++RQ +S      L  +  ++ DE    ++   ++E+      K++AT  
Sbjct: 1310 LQDTQELLQEENRQKLS------LSTKLKQVEDEKNSFREQLEEEEEAKHNLEKQIATLH 1363

Query: 83   IRLVNDKKRYERVGGG-------PKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLIS 135
             ++ + KK+ E   G         ++L +D  +E + ++ +EKV   +K  +T K RL  
Sbjct: 1364 AQVADMKKKMEDSVGCLETAEEVKRKLQKD--LEGLSQRHEEKVAAYDKLEKT-KTRLQQ 1420

Query: 136  AKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKF-QDADVAETPHPMFT 194
                L      Q      QS  N  +++   +  L E      K+ ++ D AE       
Sbjct: 1421 ELDDLLVDLDHQR-----QSACNLEKKQKKFDQLLAEEKTISAKYAEERDRAEAEAREKE 1475

Query: 195  KYGNSL---LEEARGEIRNLENVIQSQRGQIEEL---------------------EHLAE 230
                SL   LEEA  +   LE + +  R ++E+L                     E   E
Sbjct: 1476 TKALSLARALEEAMEQKAELERLNKQFRTEMEDLMSSKDDVGKSVHELEKSKRALEQQVE 1535

Query: 231  ILKTQLRRKENEI----------ELSL----------LQLREQQATDQRSNIRDNVEMIK 270
             +KTQL   E+E+          E++L          LQ R++Q+ +++  +   V  ++
Sbjct: 1536 EMKTQLEELEDELQATEDAKLRLEVNLQAMKAQFERDLQGRDEQSEEKKKQLVRQVREME 1595

Query: 271  LHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLK--EQRLKCC--- 325
               +   K  +++    K +++  K     I  D+   N DE   QL+  + ++K C   
Sbjct: 1596 AELEDERKQRSMAVAARKKLEMDLKDLEAHI--DSANKNRDEAIKQLRKLQAQMKDCMRE 1653

Query: 326  ------SLEKQLHSMKFSERRIE-------ELQDRINDLEKERELLKENYDKLYDSAFSA 372
                  S E+ L   K +E++++       +LQ+ +   E+ +   ++  D+L D   ++
Sbjct: 1654 LDDTRASREEILAQAKENEKKLKSMEAEMIQLQEELAAAERAKRQAQQERDELADEIANS 1713

Query: 373  AHEEQWKLKEQQ-LKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQY 431
            + +    L+E++ L+ +IAQLE  L+ +  +   I DRLK     N ++ Q N +L L+ 
Sbjct: 1714 SGKGALALEEKRRLEARIAQLEEELEEEQGNTELINDRLK---KANLQIDQINTDLNLE- 1769

Query: 432  LEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDL 491
                Q+ +  +++++  N+E  +   E+   +      K +    ++ L    +++ + L
Sbjct: 1770 RSHAQKNENARQQLERQNKELKVKLQEMEGTV------KSKYKASITALEAKIAQLEEQL 1823

Query: 492  ERSMRELQATHAETVQELEKTRNMLIM---QHKINKDYQMEVEAVTRKMENLQQDYELKV 548
            +   +E QA   +  +  +K +++L+    + +  + Y+ + +  + +++ L++  E   
Sbjct: 1824 DNETKERQAACKQVRRTEKKLKDVLLQVDDERRNAEQYKDQADKASTRLKQLKRQLEEAE 1883

Query: 549  EQYVHLLDIRAARIHKLEAQLKD 571
            E+        A+R  KL+ +L+D
Sbjct: 1884 EEAQR---ANASR-RKLQRELED 1902



 Score = 31.6 bits (70), Expect = 4.9
 Identities = 26/109 (23%), Positives = 52/109 (47%), Gaps = 8/109 (7%)

Query: 27   LQETSTTRTMKSRQAVSRVSREE--LEDRFLRLHDENILLKQHARKQEDKIKRMATKLIR 84
            L+E     T + + A  +V R E  L+D  L++ DE    +++A + +D+  + +T+L +
Sbjct: 1819 LEEQLDNETKERQAACKQVRRTEKKLKDVLLQVDDE----RRNAEQYKDQADKASTRLKQ 1874

Query: 85   LVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRL 133
            L    +  E          R ++ E  +E   E    + ++  +LKN+L
Sbjct: 1875 LKRQLEEAEEEAQRANASRRKLQRE--LEDATETADAMNREVSSLKNKL 1921


>gi|156104874 envoplakin [Homo sapiens]
          Length = 2033

 Score = 79.7 bits (195), Expect = 2e-14
 Identities = 138/575 (24%), Positives = 240/575 (41%), Gaps = 88/575 (15%)

Query: 35   TMKSRQAVSRVSREELEDRFLRLHDE-----NILLKQHARKQEDKIKRMATKLIRLVNDK 89
            T++ ++    V R E     LR  D      N L+  H R QE  I+    +      D+
Sbjct: 1247 TVEYKEVTQEVVRHERSPEVLREIDRLKAQLNELVNSHGRSQEQLIRLQGER------DE 1300

Query: 90   KRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTP 149
             R ER     K + ++V   E       K   LEK+ E L+  +  A Q+ +        
Sbjct: 1301 WRRERAKVETKTVSKEVVRHE-------KDPVLEKEAERLRQEVREAAQKRRAA--EDAV 1351

Query: 150  YNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIR 209
            Y     R+   RRK  E   +QE     +  +D  + E      ++   SL EE  G  R
Sbjct: 1352 YELQSKRLLLERRKPEEKVVVQEVV---VTQKDPKLREE----HSRLSGSLDEEV-GRRR 1403

Query: 210  NLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNV--- 266
             LE  +Q  R  +EE E L    + + ++   E EL  L LR Q+   +   +++ +   
Sbjct: 1404 QLELEVQQLRAGVEEQEGLLSFQEDRSKKLAVERELRQLTLRIQELEKRPPTVQEKIIME 1463

Query: 267  EMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCS 326
            E++KL K                  L++    LR   D       ELN + K  +++   
Sbjct: 1464 EVVKLEKD---------------PDLEKSTEALRWDLDQEKTQVTELNRECKNLQVQIDV 1508

Query: 327  LEKQLHSMKFSERRIEELQ-DRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQL 385
            L+K     K   + +  +Q DR+  LE ER  + E  ++   +A  A  EE  +L+E   
Sbjct: 1509 LQKAKSQEKTIYKEVIRVQKDRV--LEDERARVWEMLNR-ERTARQAREEEARRLRE--- 1562

Query: 386  KVQIAQLETALKSDLTDKTEILDRLKTERDQN-EKLVQENRELQLQYLEQKQQLDELKKR 444
              +I + ET  ++   +++E L R + + DQ   +L QE R L+ Q   ++QQ  +L++ 
Sbjct: 1563 --RIDRAETLGRTWSREESE-LQRARDQADQECGRLQQELRALERQ---KQQQTLQLQEE 1616

Query: 445  IKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQA--TH 502
             KL +Q+ +    +         AQ+ Q+   L   +  + +   + ER++R+L A  + 
Sbjct: 1617 SKLLSQKTESERQK--------AAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSR 1668

Query: 503  AETVQELEKTRNML-----IMQHKINKD---YQMEVEAVTRKMENLQ-QDYELKVEQYVH 553
             E  QE +     L     I++ +  KD   Y+     +  + + LQ Q+ E   E+   
Sbjct: 1669 EELSQETQTRETNLSTKISILEPETGKDMSPYEAYKRGIIDRGQYLQLQELECDWEEVTT 1728

Query: 554  ---------LLDIRAARIHKLEAQLKDIAYGTKQY 579
                     LLD ++ + + +EA L+      ++Y
Sbjct: 1729 SGPCGEESVLLDRKSGKQYSIEAALRCRRISKEEY 1763



 Score = 53.9 bits (128), Expect = 9e-07
 Identities = 94/485 (19%), Positives = 202/485 (41%), Gaps = 78/485 (16%)

Query: 112  IEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQ 171
            +  LQE +   EK        + +A+QQL  Q          +      RR  +   G  
Sbjct: 846  VAPLQESIQAQEKNLAKAYTEVAAAQQQLLQQLEFARKMLEKKELSEDIRRTHDAKQG-S 904

Query: 172  ECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEI 231
            E P +  +  +A  A+             LEE R  +  +++ +++QR Q+ +       
Sbjct: 905  ESPAQAGRESEALKAQ-------------LEEERKRVARVQHELEAQRSQLLQ------- 944

Query: 232  LKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQ 291
            L+TQ   +  E +  +   R+ Q     S ++  VE  +  K+       L     K +Q
Sbjct: 945  LRTQRPLERLEEKEVVEFYRDPQLEGSLSRVKAQVE--EEGKRRAGLQADLEVAAQKVVQ 1002

Query: 292  LQEKQRTL----------RISHD-ALMANGDELNMQLKEQRLKCCSLEKQLHSMKFS--- 337
            L+ K++T+          ++  D  L +   +L +Q+++ R +   +  +L  +K     
Sbjct: 1003 LESKRKTMQPHLLTKEVTQVERDPGLDSQAAQLRIQIQQLRGEDAVISARLEGLKKELLA 1062

Query: 338  -ERRIEELQDR-----INDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQ 391
             E+R  +++++     +  +EK  E++K            AA  +Q +    +L+ +I  
Sbjct: 1063 LEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDAARRKQAEEAVAKLQARIED 1122

Query: 392  LETALKSD------------------LTDKTEILDRLKTERDQNEKLVQENRELQLQY-- 431
            LE A+ S                   L + + +   L+ ER +N  L +E  +L  +Y  
Sbjct: 1123 LERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEERTKNATLARELSDLHSKYSV 1182

Query: 432  LEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDL 491
            +E+++   +L++R+    Q +     E  + +  +KA+ ++  G         S + K++
Sbjct: 1183 VEKQRPKVQLQERVHEIFQVD----PETEQEITRLKAKLQEMAGK-------RSGVEKEV 1231

Query: 492  ERSMRELQATHAE--TVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVE 549
            E+ + +L+   A+  TV+  E T+   +++H+ + +   E++ +  ++  L   +    E
Sbjct: 1232 EKLLPDLEVLRAQKPTVEYKEVTQE--VVRHERSPEVLREIDRLKAQLNELVNSHGRSQE 1289

Query: 550  QYVHL 554
            Q + L
Sbjct: 1290 QLIRL 1294



 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 119/633 (18%), Positives = 255/633 (40%), Gaps = 73/633 (11%)

Query: 29   ETSTTRTMKSRQAVSRV-SREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVN 87
            E    R  ++ +AV+++ +R E  +R +   +  +++K+  + ++D      +  +R + 
Sbjct: 1100 EEDAARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLL 1159

Query: 88   DKKRYERVGGGPKRLGRD----------VEMEEMIEQLQEKVHELEKQNETLKNRLISAK 137
            +++R +        L R+          VE +    QLQE+VHE+ + +   +  +   K
Sbjct: 1160 EEERTKNA-----TLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVDPETEQEITRLK 1214

Query: 138  QQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYG 197
             +LQ    +       +S +     K   +  +    +  +++++       H    +  
Sbjct: 1215 AKLQEMAGK-------RSGVEKEVEKLLPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVL 1267

Query: 198  NSL--LEEARGEIRNLENVIQSQ--RGQIEELEHLAEILKTQLRRKENEI---------- 243
              +  L+    E+ N     Q Q  R Q E  E   E  K + +    E+          
Sbjct: 1268 REIDRLKAQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHEKDPVLE 1327

Query: 244  -ELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRIS 302
             E   L+   ++A  +R    D V  ++  + L+E+      +  + + + +K   LR  
Sbjct: 1328 KEAERLRQEVREAAQKRRAAEDAVYELQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREE 1387

Query: 303  HDALMANGDE-----LNMQLKEQRLKCCSLEKQLHSMKFS---------ERRIEELQDRI 348
            H  L  + DE       ++L+ Q+L+   +E+Q   + F          ER + +L  RI
Sbjct: 1388 HSRLSGSLDEEVGRRRQLELEVQQLR-AGVEEQEGLLSFQEDRSKKLAVERELRQLTLRI 1446

Query: 349  NDLEK-----ERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDK 403
             +LEK     + +++ E   KL          E  +    Q K Q+ +L    K +L  +
Sbjct: 1447 QELEKRPPTVQEKIIMEEVVKLEKDPDLEKSTEALRWDLDQEKTQVTELNRECK-NLQVQ 1505

Query: 404  TEILDRLKTERDQNEK---LVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELS 460
             ++L + K++     K    VQ++R L+    +++ ++ E+  R +   Q  +  A  L 
Sbjct: 1506 IDVLQKAKSQEKTIYKEVIRVQKDRVLE----DERARVWEMLNRERTARQAREEEARRLR 1561

Query: 461  EALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQE-LEKTRNMLIMQ 519
            E +   +      + + S L +   + +++  R  +EL+A   +  Q+ L+      ++ 
Sbjct: 1562 ERIDRAETLGRTWSREESELQRARDQADQECGRLQQELRALERQKQQQTLQLQEESKLLS 1621

Query: 520  HKINKDYQMEV---EAVTRKMENLQQDYELKVEQYVHLLDIRAARIHK---LEAQLKDIA 573
             K   + Q      + ++R    + ++ +   E+   L D+ A    +    E Q ++  
Sbjct: 1622 QKTESERQKAAQRGQELSRLEAAILREKDQIYEKERTLRDLHAKVSREELSQETQTRETN 1681

Query: 574  YGTKQYKFKPEIMPDDSVDEFDETIHLERGENL 606
              TK    +PE   D S  E  +   ++RG+ L
Sbjct: 1682 LSTKISILEPETGKDMSPYEAYKRGIIDRGQYL 1714



 Score = 48.5 bits (114), Expect = 4e-05
 Identities = 103/513 (20%), Positives = 203/513 (39%), Gaps = 80/513 (15%)

Query: 103  GRDVEMEEMIEQLQEKVHELEKQNETLKNRLI---SAKQQLQTQGYRQTPYNNVQSRINT 159
            G D  +   +E L++++  LEK+   +K +++     K +   +  +      +Q   + 
Sbjct: 1044 GEDAVISARLEGLKKELLALEKREVDVKEKVVVKEVVKVEKNLEMVKAAQALRLQMEEDA 1103

Query: 160  GRRKANENA-------------GLQECPRKGIKFQDADVAETPHPM-FTKYGNSLLEEAR 205
             RRK  E A              +     K I  +   V + P  +  +    SLLEE R
Sbjct: 1104 ARRKQAEEAVAKLQARIEDLERAISSVEPKVIVKEVKKVEQDPGLLQESSRLRSLLEEER 1163

Query: 206  ----------GEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQA 255
                       ++ +  +V++ QR +++  E + EI +      E E E++ L+ + Q+ 
Sbjct: 1164 TKNATLARELSDLHSKYSVVEKQRPKVQLQERVHEIFQVD---PETEQEITRLKAKLQEM 1220

Query: 256  TDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHD-ALMANGDELN 314
              +RS +   VE      +L+     L A +      +  Q  +R      ++   D L 
Sbjct: 1221 AGKRSGVEKEVE------KLLPDLEVLRAQKPTVEYKEVTQEVVRHERSPEVLREIDRLK 1274

Query: 315  MQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAH 374
             QL E        ++QL  ++         + ++      +E+++   D + +       
Sbjct: 1275 AQLNELVNSHGRSQEQLIRLQGERDEWRRERAKVETKTVSKEVVRHEKDPVLEKEAERLR 1334

Query: 375  EEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERD---QNEKLVQENRELQLQY 431
            +E  +  +++   + A  E      L  K  +L+R K E     Q   + Q++ +L+ ++
Sbjct: 1335 QEVREAAQKRRAAEDAVYE------LQSKRLLLERRKPEEKVVVQEVVVTQKDPKLREEH 1388

Query: 432  LEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDL 491
                  LDE   R +           +L   +  ++A  E++ G LSF  + D      +
Sbjct: 1389 SRLSGSLDEEVGRRR-----------QLELEVQQLRAGVEEQEGLLSF--QEDRSKKLAV 1435

Query: 492  ERSMRELQATHAETVQELEK----TRNMLIMQH--KINKDYQMEVEAVTRKMENLQQDYE 545
            ER +R+L       +QELEK     +  +IM+   K+ KD  +E     +  E L+ D +
Sbjct: 1436 ERELRQLTL----RIQELEKRPPTVQEKIIMEEVVKLEKDPDLE-----KSTEALRWDLD 1486

Query: 546  LKVEQYVHL------LDIRAARIHKLEAQLKDI 572
             +  Q   L      L ++   + K ++Q K I
Sbjct: 1487 QEKTQVTELNRECKNLQVQIDVLQKAKSQEKTI 1519


>gi|21735548 centrosomal protein 2 [Homo sapiens]
          Length = 2442

 Score = 79.0 bits (193), Expect = 3e-14
 Identities = 120/552 (21%), Positives = 235/552 (42%), Gaps = 67/552 (12%)

Query: 25   GGLQETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIR 84
            G +QE    R M+           EL    L+  ++ + L+Q   ++ +K + +   L  
Sbjct: 1442 GQIQELEKQREMQKAAL-------ELLSLDLKKRNQEVDLQQEQIQELEKCRSVLEHLPM 1494

Query: 85   LVNDKKRYERVGGGPKR-LGRDVEMEEMIEQLQEKVHELEKQN---ETLKNRLISAKQQL 140
             V ++++   V     R L +D E +  +  L+ ++ ELEK++   E+ + ++   K+QL
Sbjct: 1495 AVQEREQKLTVQREQIRELEKDRETQRNV--LEHQLLELEKKDQMIESQRGQVQDLKKQL 1552

Query: 141  QTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSL 200
             T             ++   ++   E  G +E  R  +     D+ E    +  +     
Sbjct: 1553 VTLECLALELEENHHKMECQQKLIKELEGQRETQRVALTHLTLDLEERSQELQAQSSQIH 1612

Query: 201  LEEARG-----EIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIEL--SLLQLREQ 253
              E+       E++  +  ++SQR QIEEL+   E L   L R++ E+ L    +Q+ E 
Sbjct: 1613 DLESHSTVLARELQERDQEVKSQREQIEELQRQKEHLTQDLERRDQELMLQKERIQVLED 1672

Query: 254  QATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDEL 313
            Q T Q   + +++E IKL                    L+E+ R L      +    +E 
Sbjct: 1673 QRTRQTKILEEDLEQIKL-------------------SLRERGRELTTQRQLMQERAEEG 1713

Query: 314  NMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLY-----DS 368
                K QR    SLE     ++  E+ +E  Q+ I++L++ ++ L++    L+      S
Sbjct: 1714 KGPSKAQR---GSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETS 1770

Query: 369  AFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQN-EKLVQENREL 427
               +  E++  + +QQL+    Q E   +S L  + +   R   +RDQ  E L QE ++ 
Sbjct: 1771 LLLSQREQEIVVLQQQLQEAREQGELKEQS-LQSQLDEAQRALAQRDQELEALQQEQQQA 1829

Query: 428  QLQYLEQKQQLDELKKRIKLYN----------QENDINADELSEALLLIKAQKEQKNGDL 477
            Q Q    K++ D L+  ++  +          Q++   A  L E  L ++ ++ Q   ++
Sbjct: 1830 QGQEERVKEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEE-LAVEGRRVQALEEV 1888

Query: 478  SFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNML----IMQHKINKDYQMEVEAV 533
               ++ +S   ++ E+++  LQ   AE  QE E     L    +    + K+   E+EA+
Sbjct: 1889 LGDLRAES---REQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEAL 1945

Query: 534  TRKMENLQQDYE 545
              + ++ +   E
Sbjct: 1946 RAESQSSRHQEE 1957



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 121/648 (18%), Positives = 271/648 (41%), Gaps = 91/648 (14%)

Query: 42   VSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKR-YERVGGGPK 100
            ++ +S E +     +LH +    +Q      D+++++  +L     +K + +  +    +
Sbjct: 1233 LTALSAEAVASALHKLHQDLWKTQQTRDVLRDQVQKLEERLTDTEAEKSQVHTELQDLQR 1292

Query: 101  RLGRDVEMEEMIE----QLQEKVHELEKQNETLKNRLISAK-QQLQTQGYRQ-------- 147
            +L ++ E +   E     L+ ++ EL +   +L++RL  A+ Q+++ QG R+        
Sbjct: 1293 QLSQNQEEKSKWEGKQNSLESELMELHETMASLQSRLRRAELQRMEAQGERELLQAAKEN 1352

Query: 148  --TPYNNVQSRINTGRRKANENAGLQE---CPRKGIKFQDADVAETPHPMFTKYGNSLLE 202
                  ++Q+ +   R +A+    L+E     R  +K ++ +V               L+
Sbjct: 1353 LTAQVEHLQAAVVEARAQASAAGILEEDLRTARSALKLKNEEVESERERAQALQEQGELK 1412

Query: 203  EARGE------------IRNLENVIQSQRGQIEELEH-------LAEILKTQLRRKENEI 243
             A+G+            +   E  +++ RGQI+ELE          E+L   L+++  E+
Sbjct: 1413 VAQGKALQENLALLTQTLAEREEEVETLRGQIQELEKQREMQKAALELLSLDLKKRNQEV 1472

Query: 244  ELS-------------------LLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSA 284
            +L                     +Q REQ+ T QR  IR+      L K    + N L  
Sbjct: 1473 DLQQEQIQELEKCRSVLEHLPMAVQEREQKLTVQREQIRE------LEKDRETQRNVL-- 1524

Query: 285  MEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEEL 344
             E + ++L++K + +    ++      +L  QL         LE+  H M+  ++ I+EL
Sbjct: 1525 -EHQLLELEKKDQMI----ESQRGQVQDLKKQLVTLECLALELEENHHKMECQQKLIKEL 1579

Query: 345  QDRIN-----------DLEKERELLKENYDKLYD-SAFSAAHEEQWKLKEQQLKVQIAQL 392
            + +             DLE+  + L+    +++D  + S     + + ++Q++K Q  Q+
Sbjct: 1580 EGQRETQRVALTHLTLDLEERSQELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQI 1639

Query: 393  E--TALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQ 450
            E     K  LT   E  D+    + +  +++++ R  Q + LE  + L+++K  ++   +
Sbjct: 1640 EELQRQKEHLTQDLERRDQELMLQKERIQVLEDQRTRQTKILE--EDLEQIKLSLRERGR 1697

Query: 451  ENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLE---RSMRELQATHAETVQ 507
            E       + E     K   + + G L  +  +  +  K++E     + ELQ    +  Q
Sbjct: 1698 ELTTQRQLMQERAEEGKGPSKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQ 1757

Query: 508  ELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEA 567
            +L+     +     +    + E+  + ++++  ++  ELK +     LD     + + + 
Sbjct: 1758 QLQGLHRKVGETSLLLSQREQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQ 1817

Query: 568  QLKDIAYGTKQYKFKPEIMPD--DSVDEFDETIHLERGENLFEIHINK 613
            +L+ +    +Q + + E + +  D++    E  H+   E   E+  +K
Sbjct: 1818 ELEALQQEQQQAQGQEERVKEKADALQGALEQAHMTLKERHGELQDHK 1865



 Score = 71.2 bits (173), Expect = 6e-12
 Identities = 122/594 (20%), Positives = 252/594 (42%), Gaps = 72/594 (12%)

Query: 48   EELEDRFLRLHD---ENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGR 104
            +EL+ +  ++HD    + +L +  ++++ ++K    ++  L   K   E +    +R  R
Sbjct: 1602 QELQAQSSQIHDLESHSTVLARELQERDQEVKSQREQIEELQRQK---EHLTQDLER--R 1656

Query: 105  DVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNV-QSRINTGRRK 163
            D E+    E++Q    +  +Q + L+  L   K  L+ +G   T    + Q R   G+  
Sbjct: 1657 DQELMLQKERIQVLEDQRTRQTKILEEDLEQIKLSLRERGRELTTQRQLMQERAEEGKGP 1716

Query: 164  ANENAGLQECPR-------KGIKFQDADVAETPH----------PMFTKYGNS--LLEEA 204
            +    G  E  +       K ++ Q   + E              +  K G +  LL + 
Sbjct: 1717 SKAQRGSLEHMKLILRDKEKEVECQQEHIHELQELKDQLEQQLQGLHRKVGETSLLLSQR 1776

Query: 205  RGEIRNLENVIQSQR--GQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNI 262
              EI  L+  +Q  R  G+++E    +++ + Q    + + EL  LQ  +QQA  Q   +
Sbjct: 1777 EQEIVVLQQQLQEAREQGELKEQSLQSQLDEAQRALAQRDQELEALQQEQQQAQGQEERV 1836

Query: 263  RDNVEMIK-----LHKQLVEKSNALS-------------AMEGKFIQLQEK-----QRTL 299
            ++  + ++      H  L E+   L              A+EG+ +Q  E+     +   
Sbjct: 1837 KEKADALQGALEQAHMTLKERHGELQDHKEQARRLEEELAVEGRRVQALEEVLGDLRAES 1896

Query: 300  RISHDALMANGDELNMQLKEQRLKCCSLEKQLHS----MKFSERRIEELQDRINDLEKER 355
            R    AL+A   +   Q +E  ++  +L+         +K  ++ +E L+        + 
Sbjct: 1897 REQEKALLALQQQCAEQAQEHEVETRALQDSWLQAQAVLKERDQELEALRAESQSSRHQE 1956

Query: 356  ELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERD 415
            E  +   + L + A   AH    + KEQ L  Q A+L  +L++        LD  +    
Sbjct: 1957 EAARARAEALQE-ALGKAHAAL-QGKEQHLLEQ-AELSRSLEASTATLQASLDACQAHSR 2013

Query: 416  QNEKLVQ-ENRELQLQYLEQKQQLDELKKRIKLYNQE--NDINADELSEALLLIKAQKEQ 472
            Q E+ ++ +  E+Q Q L  ++ + +L++ +   ++E  +    ++L E  L  + Q+  
Sbjct: 2014 QLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQEREQLLEKSLAQRVQENM 2073

Query: 473  KNGDLSFLVKVDSEINKDLERSMRELQATHAETVQEL------EKTRNMLIMQHKINKDY 526
                 +   + + E  + L +S+RELQ T A+  QE+      ++  N+  + H  +K  
Sbjct: 2074 IQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQRNNLEALPHS-HKTS 2132

Query: 527  QMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYK 580
             ME +++  K+++L+   + ++E+    L    AR  +   + +D+A    Q K
Sbjct: 2133 PMEEQSL--KLDSLEPRLQRELERLQAALRQTEAREIEWREKAQDLALSLAQTK 2184



 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 117/574 (20%), Positives = 254/574 (44%), Gaps = 71/574 (12%)

Query: 65   KQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMI-------EQLQE 117
            ++  R+Q + +++ A +L R VN + + +    G    G+  E +E +       E+LQE
Sbjct: 472  REELRQQLEVLEQEAWRL-RRVNVELQLQ----GDSAQGQKEEQQEELHLAVRERERLQE 526

Query: 118  KVHELE-KQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRK 176
             +  LE KQ+E+L + LI+ ++ L++           Q+ +     +A ++         
Sbjct: 527  MLMGLEAKQSESL-SELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELSSSEN 585

Query: 177  GIKFQDADVAETPHPMFTKYGNSLLEEA--RGEIRNLENVIQSQRGQIEELEHLAEILKT 234
             +K + AD+      +        L++     ++  LE   QS   ++E  E     L+ 
Sbjct: 586  TLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARNALQV 645

Query: 235  QLRRKENEIEL-----SLLQLREQQATDQRSNIRDNVEMIKLHKQLVEK--SNALSAMEG 287
             L   E   E      + L+ + Q+A +  + ++ ++  I+  K+ ++K  S +    E 
Sbjct: 646  DLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRHQQEA 705

Query: 288  KFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDR 347
               QL++  +  +   + L     E    ++E+     +LE +L ++   ER  ++L ++
Sbjct: 706  ATTQLEQLHQEAKRQEEVLARAVQEKEALVREK----AALEVRLQAV---ERDRQDLAEQ 758

Query: 348  INDLEKERELLKENYDKLYDSAFSAAHEEQW-KLKEQQLKVQIAQLETALKSDLTDKTEI 406
            +  L   +ELL+        S F A  +    ++ + QL+VQI Q  T  K  +  +   
Sbjct: 759  LQGLSSAKELLES-------SLFEAQQQNSVIEVTKGQLEVQI-QTVTQAKEVIQGEVRC 810

Query: 407  LD-RLKTERDQNEK--------LVQENRE----LQLQYLEQKQQLDELKKRIKLYNQEND 453
            L   L TER Q E+        L Q  +E    L+ Q    ++++++L+++   + +E  
Sbjct: 811  LKLELDTERSQAEQERDAAARQLAQAEQEGKTALEQQKAAHEKEVNQLREK---WEKERS 867

Query: 454  INADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQ-----E 508
             +  EL++AL  ++ +K +    L      + +   +  ++ RE + T AE+       E
Sbjct: 868  WHQQELAKALESLEREKMELEMRLK-----EQQTEMEAIQAQREEERTQAESALCQMQLE 922

Query: 509  LEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQ 568
             EK R  L+   +     Q E+   ++++E L+QD +++  +      I   ++ + + +
Sbjct: 923  TEKERVSLL---ETLLQTQKELADASQQLERLRQDMKVQKLKEQETTGILQTQLQEAQRE 979

Query: 569  LKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLER 602
            LK+ A   +Q++     + ++S     + + L++
Sbjct: 980  LKEAA---RQHRDDLAALQEESSSLLQDKMDLQK 1010



 Score = 65.5 bits (158), Expect = 3e-10
 Identities = 101/500 (20%), Positives = 219/500 (43%), Gaps = 67/500 (13%)

Query: 115  LQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINT-GRRKANENAGLQEC 173
            L +++ +LE++N+++ +R+ +A+Q    +   Q      + R      +  +  A LQ+ 
Sbjct: 615  LNQQLLQLEEENQSVCSRMEAAEQ---ARNALQVDLAEAEKRREALWEKNTHLEAQLQKA 671

Query: 174  PRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQI-EELEHLAEIL 232
               G + Q AD+ +             +++   E R+ +    +Q  Q+ +E +   E+L
Sbjct: 672  EEAGAELQ-ADLRDIQEE------KEEIQKKLSESRHQQEAATTQLEQLHQEAKRQEEVL 724

Query: 233  KTQLRRKENEI-ELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFI- 290
               ++ KE  + E + L++R Q     R ++ + ++ +   K+L+E S   +  +   I 
Sbjct: 725  ARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQGLSSAKELLESSLFEAQQQNSVIE 784

Query: 291  ----QLQEKQRTLRISHDALMANGDELNMQLKEQRLKC-------------------CSL 327
                QL+ + +T+  + + +      L ++L  +R +                     +L
Sbjct: 785  VTKGQLEVQIQTVTQAKEVIQGEVRCLKLELDTERSQAEQERDAAARQLAQAEQEGKTAL 844

Query: 328  EKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKV 387
            E+Q  +    E+ + +L+++    EKER   ++   K  +S      E + +LKEQQ ++
Sbjct: 845  EQQKAA---HEKEVNQLREK---WEKERSWHQQELAKALESLEREKMELEMRLKEQQTEM 898

Query: 388  QIAQLETALKSDLTDKTEILDRLKTERDQ---NEKLVQENREL-----QLQYLEQKQQLD 439
            +  Q +   +    +      +L+TE+++    E L+Q  +EL     QL+ L Q  ++ 
Sbjct: 899  EAIQAQREEERTQAESALCQMQLETEKERVSLLETLLQTQKELADASQQLERLRQDMKVQ 958

Query: 440  ELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEI---NKDLERSMR 496
            +LK++     +   I   +L EA   +K    Q   DL+ L +  S +     DL++ + 
Sbjct: 959  KLKEQ-----ETTGILQTQLQEAQRELKEAARQHRDDLAALQEESSSLLQDKMDLQKQVE 1013

Query: 497  ELQA-------THAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRK-MENLQQDYELKV 548
            +L++       +     QE+++        ++I K+ + E  ++T   ME  Q+   L+ 
Sbjct: 1014 DLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREKASLTLSLMEKEQRLLVLQE 1073

Query: 549  EQYVHLLDIRAARIHKLEAQ 568
               +   ++ A R    EAQ
Sbjct: 1074 ADSIRQQELSALRQDMQEAQ 1093



 Score = 64.3 bits (155), Expect = 7e-10
 Identities = 123/584 (21%), Positives = 227/584 (38%), Gaps = 103/584 (17%)

Query: 115 LQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECP 174
           L  K  ELEK+       LI  K Q   +           S + T  +K NE+    E  
Sbjct: 249 LLAKTQELEKEAHERSQELIQLKSQGDLEKAELQDRVTELSALLTQSQKQNED---YEKM 305

Query: 175 RKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQS-QRGQIEELEHLAEILK 233
            K ++ +  ++ ET H    ++  SL   A+ E  +L+ VI+   +  +EE +++A    
Sbjct: 306 IKALR-ETVEILETNHTELMEHEASLSRNAQEEKLSLQQVIKDITQVMVEEGDNIA---- 360

Query: 234 TQLRRKENEIEL--SLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQ 291
            Q    EN +EL  S+    + Q  D+   +  +V        L  +  A+  +  +   
Sbjct: 361 -QGSGHENSLELDSSIFSQFDYQDADKALTLVRSV--------LTRRRQAVQDLRQQLAG 411

Query: 292 LQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDL 351
            QE    L+  HD     G  L  +L++   +  +L  Q            +LQ  ++ L
Sbjct: 412 CQEAVNLLQQQHDQWEEEGKALRQRLQKLTGERDTLAGQT----------VDLQGEVDSL 461

Query: 352 EKERELLKENYDKLY------------------------DSAFSAAHEEQWKL-----KE 382
            KERELL++  ++L                         DSA     E+Q +L     + 
Sbjct: 462 SKERELLQKAREELRQQLEVLEQEAWRLRRVNVELQLQGDSAQGQKEEQQEELHLAVRER 521

Query: 383 QQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDEL- 441
           ++L+  +  LE      L++   + + L++   + E L QE  E+       +Q + EL 
Sbjct: 522 ERLQEMLMGLEAKQSESLSELITLREALESSHLEGELLRQEQTEVTAALARAEQSIAELS 581

Query: 442 KKRIKLYNQENDINA-----DELSEALLLIKA-------QKEQKNGDLSFLVKVDSEINK 489
                L  +  D+ A       L+EAL L K        Q E++N  +   ++   +   
Sbjct: 582 SSENTLKTEVADLRAAAVKLSALNEALALDKVGLNQQLLQLEEENQSVCSRMEAAEQARN 641

Query: 490 DLERSMRELQA---------THAET-VQELEKT--------RNMLIMQHKINK---DYQM 528
            L+  + E +          TH E  +Q+ E+         R++   + +I K   + + 
Sbjct: 642 ALQVDLAEAEKRREALWEKNTHLEAQLQKAEEAGAELQADLRDIQEEKEEIQKKLSESRH 701

Query: 529 EVEAVTRKMENLQQDYELKVEQYVHLLDIRAA----------RIHKLEAQLKDIAYGTKQ 578
           + EA T ++E L Q+ + + E     +  + A          R+  +E   +D+A   + 
Sbjct: 702 QQEAATTQLEQLHQEAKRQEEVLARAVQEKEALVREKAALEVRLQAVERDRQDLAEQLQG 761

Query: 579 YKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSEVLQ 622
                E++     +   +   +E  +   E+ I  VT + EV+Q
Sbjct: 762 LSSAKELLESSLFEAQQQNSVIEVTKGQLEVQIQTVTQAKEVIQ 805



 Score = 60.5 bits (145), Expect = 1e-08
 Identities = 98/439 (22%), Positives = 184/439 (41%), Gaps = 74/439 (16%)

Query: 28   QETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVN 87
            QE        + Q     +   L++R   L D     K+ AR+ E+++     ++  L  
Sbjct: 1832 QEERVKEKADALQGALEQAHMTLKERHGELQDH----KEQARRLEEELAVEGRRVQAL-- 1885

Query: 88   DKKRYERVGGGPKRLGRDVE------MEEMIEQLQEKVHELEK---QNETLKNRLISAKQ 138
                 E V G  +   R+ E       ++  EQ QE  HE+E    Q+  L+ + +  ++
Sbjct: 1886 -----EEVLGDLRAESREQEKALLALQQQCAEQAQE--HEVETRALQDSWLQAQAVLKER 1938

Query: 139  QLQTQGYR-QTPYNNVQSRINTGRRKANENA-GLQECPRKGIKFQDADVAETPHPM--FT 194
              + +  R ++  +  Q      R +A + A G      +G +    + AE    +   T
Sbjct: 1939 DQELEALRAESQSSRHQEEAARARAEALQEALGKAHAALQGKEQHLLEQAELSRSLEAST 1998

Query: 195  KYGNSLLEEARGEIRNLENVIQSQRGQI--------EELEHLAEILKTQ------LRRKE 240
                + L+  +   R LE  ++ Q G+I        E+++ L + L  +       + +E
Sbjct: 1999 ATLQASLDACQAHSRQLEEALRIQEGEIQDQDLRYQEDVQQLQQALAQRDEELRHQQERE 2058

Query: 241  NEIELSLLQLREQQATDQRSNI---RDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQR 297
              +E SL Q  ++    ++ N+   R+  E+  LH+ + E    L+  E + ++L+E Q+
Sbjct: 2059 QLLEKSLAQRVQENMIQEKQNLGQEREEEEIRGLHQSVRELQLTLAQKEQEILELRETQQ 2118

Query: 298  TLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKEREL 357
              R + +AL  +     M+  EQ LK  SLE +L      +R +E LQ  +   E     
Sbjct: 2119 --RNNLEALPHSHKTSPME--EQSLKLDSLEPRL------QRELERLQAALRQTE----- 2163

Query: 358  LKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQN 417
                           A E +W+ K Q L + +AQ + ++ S L +    L     ERD  
Sbjct: 2164 ---------------AREIEWREKAQDLALSLAQTKASV-SSLQEVAMFLQASVLERDSE 2207

Query: 418  EKLVQENRELQLQYLEQKQ 436
            ++ +Q+  EL  + LE+++
Sbjct: 2208 QQRLQDELELTRRALEKER 2226



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 60/299 (20%), Positives = 138/299 (46%), Gaps = 31/299 (10%)

Query: 106  VEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKAN 165
            +E+E  +++ Q ++  ++ Q E  + +  SA  Q+Q +  ++   + +++ + T +  A+
Sbjct: 885  MELEMRLKEQQTEMEAIQAQREEERTQAESALCQMQLETEKER-VSLLETLLQTQKELAD 943

Query: 166  ENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEEL 225
             +  L+   R+ +K Q     ET   + T+     L+EA+   R L+   +  R  +  L
Sbjct: 944  ASQQLERL-RQDMKVQKLKEQETTGILQTQ-----LQEAQ---RELKEAARQHRDDLAAL 994

Query: 226  EHLAEIL---KTQLRRKENEIELSLLQLREQQAT---DQRSNIRDNVEMIKLHKQLVEKS 279
            +  +  L   K  L+++  +++  L+   + Q     + +  +R+  E  ++ K+L  + 
Sbjct: 995  QEESSSLLQDKMDLQKQVEDLKSQLVAQDDSQRLVEQEVQEKLRETQEYNRIQKELEREK 1054

Query: 280  NALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSER 339
             +L+      + L EK++ L +  +A      EL+  L++   +    +K+L +      
Sbjct: 1055 ASLT------LSLMEKEQRLLVLQEADSIRQQELSA-LRQDMQEAQGEQKELSA------ 1101

Query: 340  RIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKS 398
            ++E L+  +   EKE + L +    L +   S   E+Q +      + + AQL+  L+S
Sbjct: 1102 QMELLRQEVK--EKEADFLAQEAQLLEELEASHITEQQLRASLWAQEAKAAQLQLRLRS 1158



 Score = 35.4 bits (80), Expect = 0.34
 Identities = 33/159 (20%), Positives = 70/159 (44%), Gaps = 12/159 (7%)

Query: 380 LKEQQLKVQIAQLETALKSDLTDKTEILDR-LKTERDQNEKLVQENRELQLQYLEQKQQL 438
           +K Q L++ + +   AL+  + +      R LK  ++  ++     R+LQ + L+ +   
Sbjct: 11  MKPQSLQLVLEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWC 70

Query: 439 DELKKRIKLYN---QENDINADELSEALLLIKAQKEQK--------NGDLSFLVKVDSEI 487
            EL+KR++       +   N +E +   LL++ ++EQ+        N  L   ++    +
Sbjct: 71  QELEKRLEATGGPIPQRWENVEEPNLDELLVRLEEEQQRCESLAEVNTQLRLHMEKADVV 130

Query: 488 NKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDY 526
           NK L   + +L    +    EL +  +   M+ +  K Y
Sbjct: 131 NKALREDVEKLTVDWSRARDELMRKESQWQMEQEFFKGY 169



 Score = 35.0 bits (79), Expect = 0.44
 Identities = 68/344 (19%), Positives = 143/344 (41%), Gaps = 50/344 (14%)

Query: 243 IELSLLQLREQQATDQRSN---IRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEK---- 295
           +E  +L L++Q A +Q ++   ++++ E  +    LV K  A       + Q  EK    
Sbjct: 20  LEEQVLALQQQMAENQAASWRKLKNSQEAQQRQATLVRKLQAKVLQYRSWCQELEKRLEA 79

Query: 296 ------QRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRIN 349
                 QR   +    L    DEL ++L+E++ +C SL +    ++    + + +     
Sbjct: 80  TGGPIPQRWENVEEPNL----DELLVRLEEEQQRCESLAEVNTQLRLHMEKADVVNKA-- 133

Query: 350 DLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDR 409
            L ++ E L  ++ +  D       E QW+++++  K                       
Sbjct: 134 -LREDVEKLTVDWSRARDELMRK--ESQWQMEQEFFK---------------------GY 169

Query: 410 LKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEAL-LLIKA 468
           LK E  +   L +E    +  +LE K   D  +  ++L  +   ++   L+  L L + A
Sbjct: 170 LKGEHGRLLSLWREVVTFRRHFLEMKSATD--RDLMELKAEHVRLSGSLLTCCLRLTVGA 227

Query: 469 QKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQM 528
           Q  + NG      +  +++   L ++ +EL+    E  QEL + ++   ++    +D   
Sbjct: 228 QSREPNGSGRMDGREPAQLLLLLAKT-QELEKEAHERSQELIQLKSQGDLEKAELQDRVT 286

Query: 529 EVEAVTRKMENLQQDYELKVE---QYVHLLDIRAARIHKLEAQL 569
           E+ A+  + +   +DYE  ++   + V +L+     + + EA L
Sbjct: 287 ELSALLTQSQKQNEDYEKMIKALRETVEILETNHTELMEHEASL 330


>gi|4885583 Rho-associated, coiled-coil containing protein kinase 1
           [Homo sapiens]
          Length = 1354

 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 130/562 (23%), Positives = 239/562 (42%), Gaps = 80/562 (14%)

Query: 28  QETSTTRTMKSRQAVSRVS--REELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRL 85
           Q  +     K R   + VS  +++LED  L+   +N  L      Q  K    A  L+R 
Sbjct: 499 QRKAEQENEKRRNVENEVSTLKDQLED--LKKVSQNSQLANEKLSQLQKQLEEANDLLRT 556

Query: 86  VNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGY 145
            +D     R            EM + I QL+    EL+++N  L+N          ++  
Sbjct: 557 ESDTAVRLRKS--------HTEMSKSISQLESLNRELQERNRILEN----------SKSQ 598

Query: 146 RQTPYNNVQSRINTGRR-KANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEA 204
               Y  +Q+ +   RR + +++  + +   +    Q+    E  H    K+    +E  
Sbjct: 599 TDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQE----EVKH---LKHNLEKVEGE 651

Query: 205 RGEIRNLENVIQSQRGQIE-ELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIR 263
           R E +++ N  + ++  +E +L +  + L+ +L ++ NE +++  +L     TD+  +I 
Sbjct: 652 RKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARL-----TDKHQSIE 706

Query: 264 D--NVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQR 321
           +  +V M ++ K+L E+  A    E + +Q+ EKQ ++             L++ LK+  
Sbjct: 707 EAKSVAMCEMEKKLKEEREAREKAENRVVQI-EKQCSM-------------LDVDLKQ-- 750

Query: 322 LKCCSLEKQLHSMKFSERRIEELQDRINDLEKE--RELLKENYDKLYDSAFSAAHEEQWK 379
               S +K  H     ER  +E+++    LE+E  + LL +N  +L   AF A   +  K
Sbjct: 751 ----SQQKLEHLTGNKERMEDEVKNLTLQLEQESNKRLLLQN--ELKTQAFEA---DNLK 801

Query: 380 LKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLD 439
             E+Q+K +I  L  A +    +  ++  + +    Q  +L  +    Q      K Q+ 
Sbjct: 802 GLEKQMKQEINTLLEAKRLLEFELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVK 861

Query: 440 ELKKRIKLYNQENDINADELSEA---------LLLIKAQKEQKNGDL--SFLVKVDSEIN 488
           ELK+ I+  N+EN     EL            L   KA+ EQ    L      ++  E  
Sbjct: 862 ELKEEIEEKNRENLKKIQELQNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQESK 921

Query: 489 KDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKV 548
           K   R+ +E+      TV  LE+  +ML    +I    + E E +T KM+  +++Y+L+ 
Sbjct: 922 KAASRNRQEI-TDKDHTVSRLEEANSMLTKDIEI---LRRENEELTEKMKKAEEEYKLEK 977

Query: 549 EQYVHLLDIRAARIHKLEAQLK 570
           E+ +  L     +    E  LK
Sbjct: 978 EEEISNLKAAFEKNINTERTLK 999



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 99/501 (19%), Positives = 227/501 (45%), Gaps = 38/501 (7%)

Query: 228 LAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEG 287
           L E L+  + + E ++  + +QL+++     R++   N+++ K+ K+L E+ N    +E 
Sbjct: 424 LQESLQKTIYKLEEQLH-NEMQLKDEMEQKCRTS---NIKLDKIMKELDEEGNQRRNLES 479

Query: 288 KFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDR 347
              Q+++++  L+   +      ++ N + +    +  +L+ QL  +K   +  +   ++
Sbjct: 480 TVSQIEKEKMLLQHRINEYQRKAEQENEKRRNVENEVSTLKDQLEDLKKVSQNSQLANEK 539

Query: 348 INDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEIL 407
           ++ L+K+   L+E  D L   + +A    + +    ++   I+QLE +L  +L ++  IL
Sbjct: 540 LSQLQKQ---LEEANDLLRTESDTAV---RLRKSHTEMSKSISQLE-SLNRELQERNRIL 592

Query: 408 DRLKTERDQNEKLVQENRELQLQYL-EQKQQLDELKKRIKLYNQE--------NDINADE 458
           +  K++ D++   +Q   E + +      + + +L+ RI    +E          +  + 
Sbjct: 593 ENSKSQTDKDYYQLQAILEAERRDRGHDSEMIGDLQARITSLQEEVKHLKHNLEKVEGER 652

Query: 459 LSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETV---QELEKTRN- 514
                +L  ++KE+ N ++    K+ S + + LE+ + E + T A      Q +E+ ++ 
Sbjct: 653 KEAQDMLNHSEKEKNNLEIDLNYKLKS-LQQRLEQEVNEHKVTKARLTDKHQSIEEAKSV 711

Query: 515 -MLIMQHKINKDYQMEVEAVTRKMENLQQ----DYELKVEQYVHLLDIRAARIHKLEAQL 569
            M  M+ K+ ++ +   +A  R ++  +Q    D +LK  Q    L+       ++E ++
Sbjct: 712 AMCEMEKKLKEEREAREKAENRVVQIEKQCSMLDVDLKQSQ--QKLEHLTGNKERMEDEV 769

Query: 570 KDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSEVLQASGDKEP 629
           K++    +Q   K  ++ ++   +  E  +L+  E   +  IN +  +  +L+       
Sbjct: 770 KNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEFE----- 824

Query: 630 VTFCTYAFYDFELQTTPVVRGLHPEYNFTSQYLVHVNDLFLQYIQKNTITLEVHQAYSTE 689
           +   T  +   E Q   +   L  E  F++ Y   V +L  +  +KN   L+  Q    E
Sbjct: 825 LAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLKKIQELQNE 884

Query: 690 YETIAACQLKFHEILEKSGRI 710
            ET+A  QL   E   +S ++
Sbjct: 885 KETLAT-QLDLAETKAESEQL 904



 Score = 67.0 bits (162), Expect = 1e-10
 Identities = 98/494 (19%), Positives = 214/494 (43%), Gaps = 78/494 (15%)

Query: 29   ETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHAR--KQEDKIKRMATKLIRLV 86
            E S ++T K    +  +   E  DR    HD  ++    AR    ++++K +   L ++ 
Sbjct: 593  ENSKSQTDKDYYQLQAILEAERRDRG---HDSEMIGDLQARITSLQEEVKHLKHNLEKVE 649

Query: 87   NDKKRYERV--GGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQG 144
             ++K  + +      ++   ++++   ++ LQ+++ +   +++  K RL    Q ++   
Sbjct: 650  GERKEAQDMLNHSEKEKNNLEIDLNYKLKSLQQRLEQEVNEHKVTKARLTDKHQSIEEA- 708

Query: 145  YRQTPYNNVQSRINTGR--RKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLE 202
             +      ++ ++   R  R+  EN  +Q    K     D D+ ++   +    GN   E
Sbjct: 709  -KSVAMCEMEKKLKEEREAREKAENRVVQI--EKQCSMLDVDLKQSQQKLEHLTGNK--E 763

Query: 203  EARGEIRNL--------------ENVIQSQRGQIEELEHLAEILKTQLR---RKENEIEL 245
                E++NL              +N +++Q  + + L+ L + +K ++      +  +E 
Sbjct: 764  RMEDEVKNLTLQLEQESNKRLLLQNELKTQAFEADNLKGLEKQMKQEINTLLEAKRLLEF 823

Query: 246  SLLQLREQQATD--QRSNIRDNVE-----------MIKLHKQLVEKSNALSAMEGKFIQL 292
             L QL +Q   +  Q   ++D +E            +K  K+ +E+ N  +    K  +L
Sbjct: 824  ELAQLTKQYRGNEGQMRELQDQLEAEQYFSTLYKTQVKELKEEIEEKNRENLK--KIQEL 881

Query: 293  QEKQRTLRISHDAL--------MANG--DELNMQLKEQRLKCCSLEKQLHSMKFSERRIE 342
            Q ++ TL    D          +A G  +E   +L ++  K  S  +Q  + K  +  + 
Sbjct: 882  QNEKETLATQLDLAETKAESEQLARGLLEEQYFELTQESKKAASRNRQEITDK--DHTVS 939

Query: 343  ELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKL-KEQQLKVQIAQLETALKSDLT 401
             L++  + L K+ E+L+   ++L +    A  EE++KL KE+++    A  E  + ++ T
Sbjct: 940  RLEEANSMLTKDIEILRRENEELTEKMKKA--EEEYKLEKEEEISNLKAAFEKNINTERT 997

Query: 402  DKTEI--------------LDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKL 447
             KT+               +DR K       K  +ENR+LQL+  +++++ +++   +K 
Sbjct: 998  LKTQAVNKLAEIMNRKDFKIDRKKANTQDLRKKEKENRKLQLELNQEREKFNQMV--VKH 1055

Query: 448  YNQENDINADELSE 461
              + ND+ A  + E
Sbjct: 1056 QKELNDMQAQLVEE 1069


>gi|22538387 A-kinase anchor protein 9 isoform 2 [Homo sapiens]
          Length = 3907

 Score = 78.6 bits (192), Expect = 3e-14
 Identities = 108/524 (20%), Positives = 219/524 (41%), Gaps = 48/524 (9%)

Query: 114  QLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQEC 173
            Q+QEK   +++    L+  L+ A  +LQ     Q      +  ++  +      AG    
Sbjct: 1937 QIQEKTDIIDR----LEQELLCASNRLQELEAEQQQIQEERELLSRQKEAMKAEAG---- 1988

Query: 174  PRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILK 233
            P +    Q+ +               + ++ + +++ LE  ++ Q  +  ELE       
Sbjct: 1989 PVEQQLLQETEKLMKEKLEVQCQAEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTEL 2048

Query: 234  TQLRRKENEIELSLLQLR---EQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFI 290
              LR++   +E  L ++R   ++QA D R + RD      + +Q ++K      +  +F 
Sbjct: 2049 MDLRQQNQALEKQLEKMRKFLDEQAID-REHERD------VFQQEIQKLEQQLKVVPRFQ 2101

Query: 291  QLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSL----EKQLHSMKFSERRIEELQD 346
             + E Q              ++L   LKE+  KC  L    E+    ++     IE+L+ 
Sbjct: 2102 PISEHQTR----------EVEQLANHLKEKTDKCSELLLSKEQLQRDIQERNEEIEKLEF 2151

Query: 347  RINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEI 406
            R+ +LE+   +  + + K+ D     A E +    E  L+VQ+     A+     + T +
Sbjct: 2152 RVRELEQALLVSADTFQKVEDRKHFGAVEAK---PELSLEVQLQAERDAIDRKEKEITNL 2208

Query: 407  LDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLI 466
             ++L+  R   E+L  +N E+Q  +++ + Q  E   R++   QEN +  D++ +  L I
Sbjct: 2209 EEQLEQFR---EELENKNEEVQQLHMQLEIQKKESTTRLQELEQENKLFKDDMEKLGLAI 2265

Query: 467  KAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHK--INK 524
            K        D   L    ++I ++ E  + +L     +  Q+L+ T +  +++ K  + +
Sbjct: 2266 KESDAMSTQDQHVLFGKFAQIIQEKEVEIDQLNEQVTKLQQQLKITTDNKVIEEKNELIR 2325

Query: 525  DYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPE 584
            D + ++E +    E ++++ E ++EQ   +       I KL+ +L +I   T        
Sbjct: 2326 DLETQIECLMSDQECVKRNREEEIEQLNEV-------IEKLQQELANIGQKTSMNAHSLS 2378

Query: 585  IMPDDSVDEFDETIHLERG-ENLFEIHINKVTFSSEVLQASGDK 627
               D    + D  I  +   E   E    ++TF   VL+ +  K
Sbjct: 2379 EEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFK 2422



 Score = 73.6 bits (179), Expect = 1e-12
 Identities = 119/564 (21%), Positives = 249/564 (44%), Gaps = 95/564 (16%)

Query: 29  ETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMA-----TKLI 83
           ET    T  S  A    +++++     +L +++ LL+ + +K+ED   +++      K+ 
Sbjct: 249 ETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVY 308

Query: 84  RLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQ---QL 140
            +  DKK    V    K      E E +IE+L  K+ E EK+   LK++L +A +   +L
Sbjct: 309 EMEQDKK----VENSNKE--EIQEKETIIEELNTKIIEEEKKTLELKDKLTTADKLLGEL 362

Query: 141 QTQ-GYRQTPYNNVQSRINTGRRKANENA-----------GLQECPRKGIKFQDADVAET 188
           Q Q   +     N++  +   ++K  +++            LQ+   K  +F+   V   
Sbjct: 363 QEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRM 422

Query: 189 PHPMFTKYGNSLLEEARGEIRNL--ENVIQSQRGQIEELEHLAEILKTQLRRKENEIELS 246
                 K     LE+ R E+  +  + ++Q ++  I   +H+A++ + + R K  E+E  
Sbjct: 423 EQETQRK-----LEQLRAELDEMYGQQIVQMKQELIR--QHMAQMEEMKTRHK-GEME-- 472

Query: 247 LLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDAL 306
                   A    SNI  N + IKL    + + N         I+LQ+       ++   
Sbjct: 473 -------NALRSYSNITVNEDQIKLMNVAINELN---------IKLQD-------TNSQK 509

Query: 307 MANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLY 366
               +EL + L+E+    C+L++QL  +      +EEL      +++ R+ + E   KL 
Sbjct: 510 EKLKEELGLILEEK----CALQRQLEDL------VEELSFSREQIQRARQTIAEQESKLN 559

Query: 367 DSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRE 426
           ++  S +  E  K +         +LE   ++++T+    L+ L+ E++     + E++E
Sbjct: 560 EAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQE 619

Query: 427 LQLQYL------EQKQQLDELKKRIKL----------------YNQENDINADELSEALL 464
            +L+ L        +++L +LK+ +++                Y Q+ D   +E+S+ + 
Sbjct: 620 AELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIE 679

Query: 465 LIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAE-TVQELEKTRNMLIMQHKIN 523
            ++ +K+      + L+   S++ KDL++S+   ++      + EL+K   +L  + K  
Sbjct: 680 TMQFEKDNLITKQNQLILEISKL-KDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEK 738

Query: 524 KDYQMEVEAVTRKMENLQQDYELK 547
              + EV+ +  K E L++  + K
Sbjct: 739 GTLEQEVQELQLKTELLEKQMKEK 762



 Score = 71.6 bits (174), Expect = 4e-12
 Identities = 96/540 (17%), Positives = 223/540 (41%), Gaps = 55/540 (10%)

Query: 48   EELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVE 107
            +ELE    ++ +E  LL +     + +   +  +L++      +        ++L    +
Sbjct: 1960 QELEAEQQQIQEERELLSRQKEAMKAEAGPVEQQLLQETEKLMK--------EKLEVQCQ 2011

Query: 108  MEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANEN 167
             E++ + LQ++V  LE   E   +R I  +Q+  T+       N    +     RK  + 
Sbjct: 2012 AEKVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELMDLRQQNQALEKQLEKMRKFLDE 2071

Query: 168  AGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEH 227
              +     + +  Q+    E    +  ++   + E    E+  L N ++ +  +  EL  
Sbjct: 2072 QAIDREHERDVFQQEIQKLEQQLKVVPRF-QPISEHQTREVEQLANHLKEKTDKCSELLL 2130

Query: 228  LAEILKTQLRRKENEIELSLLQLREQQ-----ATDQRSNIRDNVEM--------IKLHKQ 274
              E L+  ++ +  EIE    ++RE +     + D    + D            + L  Q
Sbjct: 2131 SKEQLQRDIQERNEEIEKLEFRVRELEQALLVSADTFQKVEDRKHFGAVEAKPELSLEVQ 2190

Query: 275  LVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSM 334
            L  + +A+   E +   L+E+    R   +       +L+MQL+ Q+ +  +   +L  +
Sbjct: 2191 LQAERDAIDRKEKEITNLEEQLEQFREELENKNEEVQQLHMQLEIQKKESTT---RLQEL 2247

Query: 335  KFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLET 394
            +   +  ++  +++    KE + +      +    F+   +E+ +++  QL  Q+ +L+ 
Sbjct: 2248 EQENKLFKDDMEKLGLAIKESDAMSTQDQHVLFGKFAQIIQEK-EVEIDQLNEQVTKLQQ 2306

Query: 395  ALKSD-----LTDKTEILDRLKTERD---QNEKLVQENRELQLQYLEQKQQLDELKKRIK 446
             LK       + +K E++  L+T+ +    +++ V+ NRE +++ L +   +++L++ + 
Sbjct: 2307 QLKITTDNKVIEEKNELIRDLETQIECLMSDQECVKRNREEEIEQLNEV--IEKLQQELA 2364

Query: 447  LYNQENDINADELSEAL--------------LLIKAQKEQKNGDLSFLVKVDSEINKDLE 492
               Q+  +NA  LSE                L ++ Q E  N +++F+  V  E N  + 
Sbjct: 2365 NIGQKTSMNAHSLSEEADSLKHQLDVVIAEKLALEQQVETANEEMTFMKNVLKETNFKMN 2424

Query: 493  RSMREL-----QATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELK 547
            +  +EL     +    E +Q + +    + + H      ++EV      +++L+     K
Sbjct: 2425 QLTQELFSLKRERESVEKIQSIPENSVNVAIDHLSKDKPELEVVLTEDALKSLENQTYFK 2484



 Score = 70.5 bits (171), Expect = 1e-11
 Identities = 97/513 (18%), Positives = 222/513 (43%), Gaps = 74/513 (14%)

Query: 108 MEEMIEQLQEKVHELEKQNETLKNRLIS----AKQQLQ----TQGYRQTPYNNVQSRINT 159
           +E M  +L  K HE+E+ N  L+   ++      QQLQ        R      + + +  
Sbjct: 157 LEMMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQ 216

Query: 160 GRRKANENAG-----LQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENV 214
            RR+ +E         ++  +  I+FQ    +ET         NS       ++   +  
Sbjct: 217 ARREKDETMREFLELTEQSQKLQIQFQQLQASET-------LRNSTHSSTAADLLQAKQQ 269

Query: 215 IQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQ--LREQQATDQRSNIRDNVEMIKLH 272
           I + + Q+EE +HL E    Q ++++  +++S LQ  ++  +    +     N E I+  
Sbjct: 270 ILTHQQQLEEQDHLLE--DYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEK 327

Query: 273 KQLVEKSNA-LSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQL 331
           + ++E+ N  +   E K ++L++K  T     D L+    EL  Q+ ++  +  +++ +L
Sbjct: 328 ETIIEELNTKIIEEEKKTLELKDKLTTA----DKLLG---ELQEQIVQKNQEIKNMKLEL 380

Query: 332 HSMKFSERR-----------IEELQDRIN---------------DLEKERELLKENYDKL 365
            + K  ER+           +EELQ R +               + +++ E L+   D++
Sbjct: 381 TNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEM 440

Query: 366 YDSAFSAAHEEQWKLKEQQLKVQIAQLE---TALKSDLTDKTEILDRLKTERDQNEKLVQ 422
           Y        ++  ++K++ ++  +AQ+E   T  K ++ +       +    DQ + +  
Sbjct: 441 YG-------QQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNV 493

Query: 423 ENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVK 482
              EL ++  +   Q ++LK+ + L  +E      +L + +  +   +EQ       + +
Sbjct: 494 AINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQLEDLVEELSFSREQIQRARQTIAE 553

Query: 483 VDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRK----ME 538
            +S++N +  +S+  ++   AE V   E  + + +       +Y++++E + ++    ++
Sbjct: 554 QESKLN-EAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLD 612

Query: 539 NLQQDYELKVEQY-VHLLDIRAARIHKLEAQLK 570
            + +  E ++E+    LL      + KL+  L+
Sbjct: 613 RMAESQEAELERLRTQLLFSHEEELSKLKEDLE 645



 Score = 70.1 bits (170), Expect = 1e-11
 Identities = 124/572 (21%), Positives = 252/572 (44%), Gaps = 116/572 (20%)

Query: 31   STTRTMKSRQAVSRVSREELEDRF--------LRLH----DENILLKQHARKQEDKIKRM 78
            ST   +K+    +  SR+ELE +         ++L     ++N +L + A  QE +++R+
Sbjct: 566  STVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEAELERL 625

Query: 79   ATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMI--EQLQEKVH-ELEKQNETLKNRLIS 135
             T+L+    ++           +L  D+E+E  I  E+L++ +    ++Q + L+N +  
Sbjct: 626  RTQLLFSHEEEL---------SKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEM-- 674

Query: 136  AKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTK 195
              Q+++T  + +   +N+ ++ N    + ++   LQ+            +  +     T 
Sbjct: 675  -SQKIETMQFEK---DNLITKQNQLILEISKLKDLQQ-----------SLVNSKSEEMTL 719

Query: 196  YGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQA 255
              N L +E    +R  E    +   +++EL+   E+L+ Q++ KEN+++    QL  + +
Sbjct: 720  QINELQKEIE-ILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENS 778

Query: 256  T--DQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDEL 313
               D++  + D   M+K+H  + ++   +       I+ + K        + L+   ++L
Sbjct: 779  ILKDEKKTLED---MLKIHTPVSQEERLIFLDS---IKSKSKDSVWEKEIEILIEENEDL 832

Query: 314  N---MQLKEQRLKCCSLEKQLHSMKFSERRIE----ELQDRINDLEKERELLKENYDKL- 365
                +QL E+      +EKQ ++  F+E+  E    ELQ+    L K ++ L+++ +K  
Sbjct: 833  KQQCIQLNEE------IEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQE 886

Query: 366  --YDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQE 423
              Y S   A +EE   L  Q++     ++++++  +  DKT + + L    +  E + ++
Sbjct: 887  LEYKSKLKALNEE---LHLQRINPTTVKMKSSVFDE--DKTFVAETL----EMGEVVEKD 937

Query: 424  NRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFL--- 480
              EL  +         E+ KR KL          ELS+ L  +  Q +QK+G++SFL   
Sbjct: 938  TTELMEKL--------EVTKREKL----------ELSQRLSDLSEQLKQKHGEISFLNEE 979

Query: 481  VKVDSEINKDLERSMRELQA----THAETVQELEKTRNMLI-------------MQHKIN 523
            VK   +  + +    REL+       AE VQ  +   + L+                K+N
Sbjct: 980  VKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVN 1039

Query: 524  KDYQMEVEAVTR---KMENLQQDYELKVEQYV 552
            K +  E + +       EN+    E K EQ +
Sbjct: 1040 KSFGEESKIMVEDKVSFENMTVGEESKQEQLI 1071



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 122/632 (19%), Positives = 266/632 (42%), Gaps = 101/632 (15%)

Query: 57   LHDENILLKQHARKQ----EDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMI 112
            +HDE  +    A +Q    E++++ M  +L+R   + ++   +         + + E+  
Sbjct: 1565 IHDEISVSSMDASRQLMLNEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQ- 1623

Query: 113  EQLQEKVHELEKQ--------NETLKNRL-------ISAKQQLQTQGYRQTPYNNVQSRI 157
            EQLQE++  L +Q        NE L +         + A +QL   G  +       S  
Sbjct: 1624 EQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQLSLAGREKLCCELRNSST 1683

Query: 158  NTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQS 217
             T  +  NEN G  E      K  D    + P  + +    +L +     ++ L  V+++
Sbjct: 1684 QT--QNGNENQGEVEEQTFKEKELDRKPEDVPPEILSNERYALQKANNRLLKILLEVVKT 1741

Query: 218  QRGQIEEL-EHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLV 276
                 E +  H+  IL    R  +++   SL+   E +A+  +S + +       H ++ 
Sbjct: 1742 TAAVEETIGRHVLGILD---RSSKSQSSASLIWRSEAEAS-VKSCVHEE------HTRVT 1791

Query: 277  EKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKF 336
            ++S  + +  G  +   +     +++ +     G EL+ +L         ++ +   +  
Sbjct: 1792 DES--IPSYSGSDMPRNDINMWSKVTEE-----GTELSQRLVRSGFAGTEIDPENEELML 1844

Query: 337  S---------ERRIEELQDRINDLEKER----ELLKENYDKLYDSAFSAAHEEQWKLK-- 381
            +         E+ +E + +  + LE  +    EL++E++ +  ++  S   +E+ + +  
Sbjct: 1845 NISSRLQAAVEKLLEAISETSSQLEHAKVTQTELMRESFRQKQEATESLKCQEELRERLH 1904

Query: 382  -----EQQLKVQIAQLE----------TALKSDLTDKTEILDRLKTERDQNEKLVQENRE 426
                  +QL V++++ E          T  +  + +KT+I+DRL+ E       +QE   
Sbjct: 1905 EESRAREQLAVELSKAEGVIDGYADEKTLFERQIQEKTDIIDRLEQELLCASNRLQELEA 1964

Query: 427  LQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSE 486
             Q Q  E+++ L   K+ +K   +   +    L E   L+K + E         V+  +E
Sbjct: 1965 EQQQIQEERELLSRQKEAMKA--EAGPVEQQLLQETEKLMKEKLE---------VQCQAE 2013

Query: 487  -INKDLERSMRELQATHAETVQ---ELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQ 542
             +  DL++ ++ L+    E V    ELE+ +N  +M      D + + +A+ +++E +++
Sbjct: 2014 KVRDDLQKQVKALEIDVEEQVSRFIELEQEKNTELM------DLRQQNQALEKQLEKMRK 2067

Query: 543  DYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETI-HL- 600
              + +     H  D+    I KLE QLK +       +F+P  + +    E ++   HL 
Sbjct: 2068 FLDEQAIDREHERDVFQQEIQKLEQQLKVVP------RFQP--ISEHQTREVEQLANHLK 2119

Query: 601  ERGENLFEIHINKVTFSSEVLQASGDKEPVTF 632
            E+ +   E+ ++K     ++ + + + E + F
Sbjct: 2120 EKTDKCSELLLSKEQLQRDIQERNEEIEKLEF 2151



 Score = 55.5 bits (132), Expect = 3e-07
 Identities = 98/442 (22%), Positives = 193/442 (43%), Gaps = 90/442 (20%)

Query: 196  YGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQA 255
            Y +S   E+  + R  E ++  Q+  +EE   L    +T+L        + LL   EQ+ 
Sbjct: 3010 YDSSQSHESFSDWRG-ELLLALQQVFLEERSVLLAAFRTELTALGTTDAVGLLNCLEQRI 3068

Query: 256  TDQRSNIRDNVEMIKL--HKQLVEKSNALSA-MEGKFIQLQEKQRTLRISHDALMANGDE 312
             +Q    +  +E ++    + L+ +  AL A M G+ I L+ +Q + + S + L     E
Sbjct: 3069 QEQGVEYQAAMECLQKADRRSLLSEIQALHAQMNGRKITLKREQESEKPSQELL-----E 3123

Query: 313  LNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRIND-----LEKERELLKENYDKLYD 367
             N+Q K+ ++    ++ +L SMK    R  ELQ++++       E + EL +   +   +
Sbjct: 3124 YNIQQKQSQM--LEMQVELSSMK---DRATELQEQLSSEKMVVAELKSELAQTKLE--LE 3176

Query: 368  SAFSAAHEEQWKLKEQQLKV-----QIAQLETALKSDLTDKTEI---LDRLKT------E 413
            +   A H+   +L+  +L+V     ++  L   L S+     E+   L++ K       E
Sbjct: 3177 TTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSRELQWALEKEKAKLGRSEE 3236

Query: 414  RDQN---------EKLVQENRELQLQYLEQKQQLDELKKRIK----LYNQENDINADELS 460
            RD+          E   Q N +L L   +QKQ L+E +++I+    LY+ +         
Sbjct: 3237 RDKEELEDLKFSLESQKQRNLQLNLLLEQQKQLLNESQQKIESQRMLYDAQLSEEQGRNL 3296

Query: 461  EALLLIKAQKEQKNGDLSFLVKVDSEINKDLERS-------------------MRELQAT 501
            E  +L++++K +   ++S  +  + E++  L+ S                    ++L+  
Sbjct: 3297 ELQVLLESEKVRIR-EMSSTLDRERELHAQLQSSDGTGQSRPPLPSEDLLKELQKQLEEK 3355

Query: 502  HA-----------------ETVQELEKTRNM----LIMQHKINKDYQMEVEAVTRKMENL 540
            H+                 +T Q++EK R +    L  + + N + Q ++  +  K+E+L
Sbjct: 3356 HSRIVELLNETEKYKLDSLQTRQQMEKDRQVHRKTLQTEQEANTEGQKKMHELQSKVEDL 3415

Query: 541  QQDYELKVEQYVHLLDIRAARI 562
            Q+  E K  Q V+ LD+   R+
Sbjct: 3416 QRQLEEK-RQQVYKLDLEGQRL 3436



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 65/316 (20%), Positives = 132/316 (41%), Gaps = 21/316 (6%)

Query: 311 DELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAF 370
           +ELN +L+E R+   +  + L  ++  E  I++    I  L    +  +   D+      
Sbjct: 172 EELNRELEEMRVTYGT--EGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFL 229

Query: 371 SAAHEEQ-WKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQL 429
               + Q  +++ QQL+       +   S   D  +   ++ T + Q E+      + Q 
Sbjct: 230 ELTEQSQKLQIQFQQLQASETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQK 289

Query: 430 QYLEQKQQLDELKKRIKLYNQEND-----INADELSEALLLIKAQKEQKNGDLSFLVKVD 484
           +  +   Q+  L+++IK+Y  E D      N +E+ E   +I    E+ N  +    K  
Sbjct: 290 KKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETII----EELNTKIIEEEKKT 345

Query: 485 SEINKDLERSMRELQATHAETVQELEKTRNM-LIMQHKINKDYQM--EVEAVTRKMENLQ 541
            E+   L  + + L     + VQ+ ++ +NM L + +   K+ Q   E++ +   +E LQ
Sbjct: 346 LELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQ 405

Query: 542 ----QDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVD-EFDE 596
               +D + + +    +      ++ +L A+L D  YG +  + K E++       E  +
Sbjct: 406 KRNHKDSQFETDIVQRMEQETQRKLEQLRAEL-DEMYGQQIVQMKQELIRQHMAQMEEMK 464

Query: 597 TIHLERGENLFEIHIN 612
           T H    EN    + N
Sbjct: 465 TRHKGEMENALRSYSN 480



 Score = 38.1 bits (87), Expect = 0.052
 Identities = 98/532 (18%), Positives = 210/532 (39%), Gaps = 73/532 (13%)

Query: 35   TMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYER 94
            T+K  Q   + S+E LE    +   + + ++      +D+    AT+L   ++ +K    
Sbjct: 3107 TLKREQESEKPSQELLEYNIQQKQSQMLEMQVELSSMKDR----ATELQEQLSSEKMV-- 3160

Query: 95   VGGGPKRLGRD-VEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNV 153
            V      L +  +E+E  ++   + + ELE     +K++         T    Q     +
Sbjct: 3161 VAELKSELAQTKLELETTLKAQHKHLKELEAFRLEVKDKTDEVHLLNDTLASEQKKSREL 3220

Query: 154  QSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLEN 213
            Q  +   + K   +    +   + +KF      +    +     N LLE+ +  +   + 
Sbjct: 3221 QWALEKEKAKLGRSEERDKEELEDLKFSLESQKQRNLQL-----NLLLEQQKQLLNESQQ 3275

Query: 214  VIQSQR-----------GQIEELEHLAEILKTQLRRKENEIELSL---LQLREQQATDQR 259
             I+SQR           G+  EL+ L E  K ++R   + ++       QL+    T Q 
Sbjct: 3276 KIESQRMLYDAQLSEEQGRNLELQVLLESEKVRIREMSSTLDRERELHAQLQSSDGTGQS 3335

Query: 260  SNIRDNVEMIK-LHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLK 318
                 + +++K L KQL EK +       + ++L  +    ++  D+L           K
Sbjct: 3336 RPPLPSEDLLKELQKQLEEKHS-------RIVELLNETEKYKL--DSLQTR----QQMEK 3382

Query: 319  EQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKL----------YDS 368
            ++++   +L+ +  +    ++++ ELQ ++ DL+++ E  ++   KL             
Sbjct: 3383 DRQVHRKTLQTEQEANTEGQKKMHELQSKVEDLQRQLEEKRQQVYKLDLEGQRLQGIMQE 3442

Query: 369  AFSAAHEEQWKLKEQQLKVQIAQLET--ALKSDLTDKTEILDRLKTERDQNE--KLVQEN 424
                  E + K + +++  Q     T  +L SD T    +  +++ E  ++   KL++ N
Sbjct: 3443 FQKQELEREEKRESRRILYQNLNEPTTWSLTSDRTRNWVLQQKIEGETKESNYAKLIEMN 3502

Query: 425  R-----ELQLQYLEQKQQLDELKKRI-----------KLYNQENDINADELSEALLLIKA 468
                    +L+ + QK Q    K ++           +  + E+ I   E  + ++L   
Sbjct: 3503 GGGTGCNHELEMIRQKLQCVASKLQVLPQKASERLQFETADDEDFIWVQENIDEIILQLQ 3562

Query: 469  QKEQKNGDLSFLVKVDSEINKDLERSMR---ELQATHAETVQELEKTRNMLI 517
            +   + G+   LV   +      ER +R   EL    ++  +E    RNM++
Sbjct: 3563 KLTGQQGEEPSLVSPSTSCGSLTERLLRQNAELTGHISQLTEEKNDLRNMVM 3614



 Score = 37.4 bits (85), Expect = 0.089
 Identities = 75/358 (20%), Positives = 153/358 (42%), Gaps = 44/358 (12%)

Query: 207  EIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNV 266
            ++ NLE++  + + ++  L+ L    KT+L  +  E+E SL+   +QQ  +   N    +
Sbjct: 1310 QMTNLEDIDVNHKSKLSSLQDLE---KTKLEEQVQELE-SLISSLQQQLKETEQNYEAEI 1365

Query: 267  EMIKLHKQLVEKSNALSAM--EGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKC 324
              ++   Q V +S    ++  +   I   + QRT+                         
Sbjct: 1366 HCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPG---------------------S 1404

Query: 325  CSLEKQLHSMKFS-ERRIEELQDRINDLEKE-RELLKENYDKLYDSAFSAAHEEQWKLKE 382
            C  +    +++FS E  ++E  + +  LEK+ +E L+E   K+  S  S A  +Q +L  
Sbjct: 1405 CVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEVAKVIVS-MSIAFAQQTELSR 1463

Query: 383  QQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQL--QYLEQKQQLDE 440
                 +         +    +    + +K  +DQ      E  +++   ++    ++L E
Sbjct: 1464 ISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKELGE 1523

Query: 441  LKKRIKLYNQE-NDINADELSEALLLIKAQKEQKNGDLSFLVK--VDSEINKDLERSMRE 497
              K I L N + +DI   E  + +L I   +E  + D +F+V+  +  EI+     + R+
Sbjct: 1524 HGKEILLSNSDPHDI--PESKDCVLTI--SEEMFSKDKTFIVRQSIHDEISVSSMDASRQ 1579

Query: 498  LQATHAETVQELEKTRNMLIMQHKINKD-YQMEVEAVTRKMENLQQDYELKVEQYVHL 554
            L        ++LE  R  L+ Q++ ++   ++  +A  R+ME  ++D E   E+   L
Sbjct: 1580 LMLNE----EQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQEQLQEEIKRL 1633



 Score = 36.2 bits (82), Expect = 0.20
 Identities = 100/577 (17%), Positives = 230/577 (39%), Gaps = 86/577 (14%)

Query: 37   KSRQAVSRVSR-EELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERV 95
            K  Q +  +S+ ++L+   +    E + L+ +  ++E +I R   K    +  + +  ++
Sbjct: 691  KQNQLILEISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQL 750

Query: 96   GGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQS 155
                K    + +M+E    LQEK  +LE +N  LK+     K+ L+      TP +  + 
Sbjct: 751  ----KTELLEKQMKEKENDLQEKFAQLEAENSILKDE----KKTLEDMLKIHTPVSQEER 802

Query: 156  RINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVI 215
             I                      F D+  +++   ++ K    L+EE            
Sbjct: 803  LI----------------------FLDSIKSKSKDSVWEKEIEILIEEN----------- 829

Query: 216  QSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQL 275
            +  + Q  +L    E  +      E   E++  +L+E+ A      ++D++E  K +KQ 
Sbjct: 830  EDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYAC--LLKVKDDLEDSK-NKQE 886

Query: 276  VEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMK 335
            +E  + L A+  +    +    T+++       +   +   L+   +      + +  ++
Sbjct: 887  LEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLE 946

Query: 336  FSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETA 395
             ++R   EL  R++DL    E LK+ + ++   +F     +  K +++Q+ ++  +LE  
Sbjct: 947  VTKREKLELSQRLSDLS---EQLKQKHGEI---SFLNEEVKSLKQEKEQVSLRCRELEII 1000

Query: 396  LKSDLTDKTEILD-RLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDI 454
            +  +  +  +  D ++ +  D    +     E              + K  K + +E+ I
Sbjct: 1001 INHNRAENVQSCDTQVSSLLDGVVTMTSRGAE------------GSVSKVNKSFGEESKI 1048

Query: 455  NA-DELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTR 513
               D++S   + +  + +Q+   L  L  V  E           L+AT      +L+K  
Sbjct: 1049 MVEDKVSFENMTVGEESKQEQLILDHLPSVTKE---------SSLRATQPSENDKLQKEL 1099

Query: 514  NMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVH------LLDIRAARIHKLEA 567
            N+L  +     D ++++EA    +  +   +  +V +Y+       L  ++   I   E 
Sbjct: 1100 NVLKSE---QNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEE 1156

Query: 568  QLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGE 604
            ++K++    K ++ + + M      +  + +HL  G+
Sbjct: 1157 KIKEL---QKIHQLELQTMKTQETGDEGKPLHLLIGK 1190



 Score = 31.2 bits (69), Expect = 6.4
 Identities = 65/343 (18%), Positives = 144/343 (41%), Gaps = 29/343 (8%)

Query: 114  QLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQEC 173
            +L+E+V ELE    +L+ +L   +Q  + +       + +Q R+    +  +E+      
Sbjct: 1335 KLEEQVQELESLISSLQQQLKETEQNYEAE------IHCLQKRL----QAVSESTVPPSL 1384

Query: 174  PRKGIKFQDADVAETPHP-MFTKYGNSLLEEARGE--IRNLENVIQSQRGQIEEL--EHL 228
            P   +   ++D   T +P    K       E  GE  ++   N+++    Q +E   E +
Sbjct: 1385 PVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVKLLEKQYQEQLEEEV 1444

Query: 229  AEILKTQLRRKENEIELSLLQ-LREQQATDQRSNIRDNVEMIKLHK-QLVEKSNALSAME 286
            A+++ +       + ELS +   +E  A+ ++++     E    ++ +L +        E
Sbjct: 1445 AKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFE 1504

Query: 287  GKFIQLQEKQRTL-----RISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRI 341
               ++ +E+ + L         + L++N D  ++   +  +   S E       F  R+ 
Sbjct: 1505 TVDVKFKEEFKPLSKELGEHGKEILLSNSDPHDIPESKDCVLTISEEMFSKDKTFIVRQS 1564

Query: 342  EELQDRINDLEKERELLKENYDKLYD--SAFSAAHEEQWKLKEQQLKVQIAQLETAL--K 397
               +  ++ ++  R+L+  N ++L D        ++E  +  E   +  + Q+E     +
Sbjct: 1565 IHDEISVSSMDASRQLML-NEEQLEDMRQELVRQYQEHQQATELLRQAHMRQMERQREDQ 1623

Query: 398  SDLTDKTEILDRLKTERD--QNEKLVQENRELQLQYLEQKQQL 438
              L ++ + L+R   +R    NE LV E   + L+ LE  +QL
Sbjct: 1624 EQLQEEIKRLNRQLAQRSSIDNENLVSERERVLLEELEALKQL 1666



 Score = 31.2 bits (69), Expect = 6.4
 Identities = 54/278 (19%), Positives = 118/278 (42%), Gaps = 32/278 (11%)

Query: 104  RDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRK 163
            R+ E+   I  L  ++ ELE Q   +   LI  K+Q++     +      + ++   ++ 
Sbjct: 2593 REDELGSDISALTLRISELESQVVEMHTSLILEKEQVE---IAEKNVLEKEKKLLELQKL 2649

Query: 164  ANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNS----LLEEARGEIRNLENVIQSQR 219
               N   Q    K    QD +V +T   +F     S     LE  R E    +  + S +
Sbjct: 2650 LEGNEKKQREKEKKRSPQDVEVLKTTTELFHSNEESGFFNELEALRAESVATKAELASYK 2709

Query: 220  GQIEELEH---LAEILKTQLRRKENEIELSLLQLREQQA---TDQRSNIRDNVEMIKLHK 273
             + E+L+    + E   T L++  +++   L + +E+ +    +  + ++++ +      
Sbjct: 2710 EKAEKLQEELLVKETNMTSLQKDLSQVRDHLAEAKEKLSILEKEDETEVQESKKACMFEP 2769

Query: 274  QLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMAN-GDELNMQLKEQRLKCCSLEKQLH 332
              ++ S ++++     +++    +T +I    L+ N G ++N+Q +      CS E+   
Sbjct: 2770 LPIKLSKSIASQTDGTLKISSSNQTPQI----LVKNAGIQINLQSE------CSSEEVTE 2819

Query: 333  SMKFSERRIEELQD----RINDLE----KERELLKENY 362
             +     +IE++Q+     I D+E     E E LK  +
Sbjct: 2820 IISQFTEKIEKMQELHAAEILDMESRHISETETLKREH 2857


>gi|116284396 myosin, heavy chain 14 isoform 1 [Homo sapiens]
          Length = 2003

 Score = 78.2 bits (191), Expect = 5e-14
 Identities = 101/387 (26%), Positives = 180/387 (46%), Gaps = 62/387 (16%)

Query: 207  EIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNV 266
            ++   + V+Q++  ++++++ L +    Q  R+  E++  + QL E++A      +R   
Sbjct: 871  QVTRQDEVLQARAQELQKVQELQQ----QSAREVGELQGRVAQLEEERAR-LAEQLRAEA 925

Query: 267  EMI--------KLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLK 318
            E+         +L  +  E    +S +E +  + +E  R ++     L  +  EL   L+
Sbjct: 926  ELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLE 985

Query: 319  EQRLKCCSLEKQLHSMKFSERRIEE----LQDRINDLEKERELLKENYDKLYDSAFSAAH 374
             +      L+ +  + +   ++ EE    L+D+ + L KER+LL+   D+L + +  AA 
Sbjct: 986  AEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLE---DRLAEFSSQAAE 1042

Query: 375  EEQW--KLKEQQLKVQ--IAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQ 430
            EE+    L + +LK +  IA +E  L+ +   + E L++LK   D       E+ ELQ Q
Sbjct: 1043 EEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE-LEKLKRRLDG------ESSELQEQ 1095

Query: 431  YLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKD 490
             +EQ+Q+ +EL  R +L  +E     +EL  AL    A+ E + G  + L+K        
Sbjct: 1096 MVEQQQRAEEL--RAQLGRKE-----EELQAAL----ARAEDEGGARAQLLK-------- 1136

Query: 491  LERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKME------NLQQDY 544
               S+RE QA  AE  ++LE  R       K  +D   E+EA+  ++E      N QQ+ 
Sbjct: 1137 ---SLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQEL 1193

Query: 545  ELKVEQYVHLLD---IRAARIHKLEAQ 568
              K EQ V  L        RIH+   Q
Sbjct: 1194 RSKREQEVTELKKTLEEETRIHEAAVQ 1220



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 108/489 (22%), Positives = 199/489 (40%), Gaps = 82/489 (16%)

Query: 29   ETSTTRTMKSRQAVSRVSR------EELEDRFLRLHDENIL---LKQHARKQEDKIKRMA 79
            E  T R  +  + V R+ R      +EL+D  + L  +  L   L++  RK +  +    
Sbjct: 1427 EALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEK 1486

Query: 80   TKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQ 139
              ++R V +++R E    G +R  R + +   +E+ QE   ELE+QN  L+  L +    
Sbjct: 1487 AAVLRAVEERERAE--AEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSS 1544

Query: 140  LQTQGYRQTPYNNVQSRINTGRRKANE-NAGLQECPRKGIKFQDAD--VAETPHPMFTKY 196
                G      + ++       + AN+  A + E   +    +DA   +  T   + T++
Sbjct: 1545 KDDVG---KSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQH 1601

Query: 197  GNSLL-EEARGEIRNLENVIQSQRGQIE----------------ELEHLAEILKTQLRRK 239
               L   +  GE R  +   Q +  ++E                +LE   E LK Q+   
Sbjct: 1602 ERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASA 1661

Query: 240  ENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLV-----EKSNALSAMEGKFIQLQE 294
                E ++ QLR+ QA  Q   +   VE  +  ++ +     E    L  +E + ++LQE
Sbjct: 1662 GQGKEEAVKQLRKMQA--QMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQE 1719

Query: 295  KQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKE 354
            +      +      + DE+  ++    L   ++   L   +  E R+ +L++ + + +  
Sbjct: 1720 ELAASDRARRQAQQDRDEMADEVANGNLSKAAI---LEEKRQLEGRLGQLEEELEEEQSN 1776

Query: 355  RELLKENYDKLY------------DSAFSAAHEEQWKLKEQQLKVQIAQLE--------- 393
             ELL + Y KL             + +FSA  E       QQL+ QI +L          
Sbjct: 1777 SELLNDRYRKLLLQVESLTTELSAERSFSAKAES----GRQQLERQIQELRGRLGEEDAG 1832

Query: 394  ---------TALKSDLTDKTEILDRLKTERDQNEKLVQEN----RELQLQYLEQKQQLDE 440
                      AL+S L    E L++   ER  + KLV+      +E+ LQ  E+++  D+
Sbjct: 1833 ARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQ 1892

Query: 441  LKKRIKLYN 449
            L+ +++  N
Sbjct: 1893 LRDQLEKGN 1901



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 125/628 (19%), Positives = 249/628 (39%), Gaps = 59/628 (9%)

Query: 29   ETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVND 88
            E    + ++  +  +    ++ E+  L L D+N  L +  +  ED++   +++       
Sbjct: 987  EEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEK 1046

Query: 89   KKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQ- 147
             K   ++     RL  +  + +M ++L+ K  +  ++ E LK RL     +LQ Q   Q 
Sbjct: 1047 VKSLNKL-----RLKYEATIADMEDRLR-KEEKGRQELEKLKRRLDGESSELQEQMVEQQ 1100

Query: 148  -------TPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFT------ 194
                         +  +     +A +  G +    K ++   A +AE    + +      
Sbjct: 1101 QRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVART 1160

Query: 195  ---KYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRR---KENEIELSLL 248
               K    L EE       LE+ + S   Q +EL    E   T+L++   +E  I  + +
Sbjct: 1161 KAEKQRRDLGEELEALRGELEDTLDSTNAQ-QELRSKREQEVTELKKTLEEETRIHEAAV 1219

Query: 249  QLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMA 308
            Q   Q+       + + +E  +  K   EK+    A+E +  +L+ +  +L+ +      
Sbjct: 1220 QELRQRHGQALGELAEQLEQARRGKGAWEKTRL--ALEAEVSELRAELSSLQTARQEGEQ 1277

Query: 309  NGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDS 368
                L +QL+E + +    E+         +R +   + ++    E E       K   S
Sbjct: 1278 RRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSS 1337

Query: 369  AFSAAHEEQWKLKEQ-QLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENREL 427
              +  H+ Q  L+E+ + K+ +     A++++     E L+     R+      +  REL
Sbjct: 1338 TEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARE------RAGREL 1391

Query: 428  QLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEI 487
            Q      + QL E ++R     QE +  A E  E      A++ +    L+  +   +E 
Sbjct: 1392 Q----TAQAQLSEWRRR-----QEEEAGALEAGEEARRRAAREAEA---LTQRLAEKTET 1439

Query: 488  NKDLERSMRELQATHAETVQELEKTRNMLI----MQHKINKDYQMEVEAVTRKMENLQQD 543
               LER  R LQ    +   +LE+ R ++      Q K ++    E  AV R +E  ++ 
Sbjct: 1440 VDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERA 1499

Query: 544  YELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIH-LER 602
                 E+    L +  A   + EA+ +++    +  + + E +   S D+  +++H LER
Sbjct: 1500 EAEGREREARALSLTRALEEEQEAR-EELERQNRALRAELEALL-SSKDDVGKSVHELER 1557

Query: 603  GENLFEIHIN----KVTFSSEVLQASGD 626
               + E   N    +VT   + L A+ D
Sbjct: 1558 ACRVAEQAANDLRAQVTELEDELTAAED 1585



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 125/662 (18%), Positives = 254/662 (38%), Gaps = 107/662 (16%)

Query: 48   EELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVE 107
            +EL     +LHD   LL++  R +     R+          +++ E      +R GR+++
Sbjct: 1333 KELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQ 1392

Query: 108  -----MEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRR 162
                 + E   + +E+   LE   E  +     A ++ +    R         R+  GRR
Sbjct: 1393 TAQAQLSEWRRRQEEEAGALEAGEEARRR----AAREAEALTQRLAEKTETVDRLERGRR 1448

Query: 163  KANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQI 222
            +  +         +    Q   +  T      K+   L EE    +R +E   + +R + 
Sbjct: 1449 RLQQELDDATMDLE----QQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVE---ERERAEA 1501

Query: 223  EELEHLAEIL-------KTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIK----- 270
            E  E  A  L       + Q  R+E E +   L+   +     + ++  +V  ++     
Sbjct: 1502 EGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRV 1561

Query: 271  -------LHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQ--- 320
                   L  Q+ E  + L+A E   ++L+   + L+  H+  +   DE   + + Q   
Sbjct: 1562 AEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAK 1621

Query: 321  RLKCCSLEKQ---------LHSMKFSERRIEEL-----------QDRINDLEKERELLKE 360
            +L+   +E+          + + K  E  +EEL           ++ +  L K +  +KE
Sbjct: 1622 QLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKE 1681

Query: 361  NYDKLYDSA------FSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTER 414
             + ++ ++       FS   E + +LK  + +V        L+ +L        + + +R
Sbjct: 1682 LWREVEETRTSREEIFSQNRESEKRLKGLEAEV------LRLQEELAASDRARRQAQQDR 1735

Query: 415  DQNEKLVQENRELQLQYLEQKQQLD----ELKKRIKLYNQENDINADELSEALLLIKAQK 470
            D+    V      +   LE+K+QL+    +L++ ++     +++  D   + LL +++  
Sbjct: 1736 DEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLT 1795

Query: 471  EQKNGDLSFLVKVDSEINKDLERSMREL-----------QATHAETVQELEKTRNMLIMQ 519
             + + + SF  K +S   + LER ++EL           +A H  T+  LE        Q
Sbjct: 1796 TELSAERSFSAKAESG-RQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQ 1854

Query: 520  HKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQY 579
             +     ++    + R+ E   ++  L+VE+   + D       +L  QL+      KQ 
Sbjct: 1855 LEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVAD-------QLRDQLEKGNLRVKQL 1907

Query: 580  KFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSE-------VLQASGDKEPVTF 632
            K + E       +  +E    + G    +  +  VT S+E        L+    + P+TF
Sbjct: 1908 KRQLE-------EAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTF 1960

Query: 633  CT 634
             T
Sbjct: 1961 TT 1962


>gi|116284394 myosin, heavy chain 14 isoform 2 [Homo sapiens]
          Length = 1995

 Score = 78.2 bits (191), Expect = 5e-14
 Identities = 101/387 (26%), Positives = 180/387 (46%), Gaps = 62/387 (16%)

Query: 207  EIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNV 266
            ++   + V+Q++  ++++++ L +    Q  R+  E++  + QL E++A      +R   
Sbjct: 863  QVTRQDEVLQARAQELQKVQELQQ----QSAREVGELQGRVAQLEEERAR-LAEQLRAEA 917

Query: 267  EMI--------KLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLK 318
            E+         +L  +  E    +S +E +  + +E  R ++     L  +  EL   L+
Sbjct: 918  ELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLE 977

Query: 319  EQRLKCCSLEKQLHSMKFSERRIEE----LQDRINDLEKERELLKENYDKLYDSAFSAAH 374
             +      L+ +  + +   ++ EE    L+D+ + L KER+LL+   D+L + +  AA 
Sbjct: 978  AEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLE---DRLAEFSSQAAE 1034

Query: 375  EEQW--KLKEQQLKVQ--IAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQ 430
            EE+    L + +LK +  IA +E  L+ +   + E L++LK   D       E+ ELQ Q
Sbjct: 1035 EEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE-LEKLKRRLDG------ESSELQEQ 1087

Query: 431  YLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKD 490
             +EQ+Q+ +EL  R +L  +E     +EL  AL    A+ E + G  + L+K        
Sbjct: 1088 MVEQQQRAEEL--RAQLGRKE-----EELQAAL----ARAEDEGGARAQLLK-------- 1128

Query: 491  LERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKME------NLQQDY 544
               S+RE QA  AE  ++LE  R       K  +D   E+EA+  ++E      N QQ+ 
Sbjct: 1129 ---SLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQEL 1185

Query: 545  ELKVEQYVHLLD---IRAARIHKLEAQ 568
              K EQ V  L        RIH+   Q
Sbjct: 1186 RSKREQEVTELKKTLEEETRIHEAAVQ 1212



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 108/489 (22%), Positives = 199/489 (40%), Gaps = 82/489 (16%)

Query: 29   ETSTTRTMKSRQAVSRVSR------EELEDRFLRLHDENIL---LKQHARKQEDKIKRMA 79
            E  T R  +  + V R+ R      +EL+D  + L  +  L   L++  RK +  +    
Sbjct: 1419 EALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEK 1478

Query: 80   TKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQ 139
              ++R V +++R E    G +R  R + +   +E+ QE   ELE+QN  L+  L +    
Sbjct: 1479 AAVLRAVEERERAE--AEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSS 1536

Query: 140  LQTQGYRQTPYNNVQSRINTGRRKANE-NAGLQECPRKGIKFQDAD--VAETPHPMFTKY 196
                G      + ++       + AN+  A + E   +    +DA   +  T   + T++
Sbjct: 1537 KDDVG---KSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQH 1593

Query: 197  GNSLL-EEARGEIRNLENVIQSQRGQIE----------------ELEHLAEILKTQLRRK 239
               L   +  GE R  +   Q +  ++E                +LE   E LK Q+   
Sbjct: 1594 ERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASA 1653

Query: 240  ENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLV-----EKSNALSAMEGKFIQLQE 294
                E ++ QLR+ QA  Q   +   VE  +  ++ +     E    L  +E + ++LQE
Sbjct: 1654 GQGKEEAVKQLRKMQA--QMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQE 1711

Query: 295  KQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKE 354
            +      +      + DE+  ++    L   ++   L   +  E R+ +L++ + + +  
Sbjct: 1712 ELAASDRARRQAQQDRDEMADEVANGNLSKAAI---LEEKRQLEGRLGQLEEELEEEQSN 1768

Query: 355  RELLKENYDKLY------------DSAFSAAHEEQWKLKEQQLKVQIAQLE--------- 393
             ELL + Y KL             + +FSA  E       QQL+ QI +L          
Sbjct: 1769 SELLNDRYRKLLLQVESLTTELSAERSFSAKAES----GRQQLERQIQELRGRLGEEDAG 1824

Query: 394  ---------TALKSDLTDKTEILDRLKTERDQNEKLVQEN----RELQLQYLEQKQQLDE 440
                      AL+S L    E L++   ER  + KLV+      +E+ LQ  E+++  D+
Sbjct: 1825 ARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQ 1884

Query: 441  LKKRIKLYN 449
            L+ +++  N
Sbjct: 1885 LRDQLEKGN 1893



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 125/628 (19%), Positives = 249/628 (39%), Gaps = 59/628 (9%)

Query: 29   ETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVND 88
            E    + ++  +  +    ++ E+  L L D+N  L +  +  ED++   +++       
Sbjct: 979  EEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEK 1038

Query: 89   KKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQ- 147
             K   ++     RL  +  + +M ++L+ K  +  ++ E LK RL     +LQ Q   Q 
Sbjct: 1039 VKSLNKL-----RLKYEATIADMEDRLR-KEEKGRQELEKLKRRLDGESSELQEQMVEQQ 1092

Query: 148  -------TPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFT------ 194
                         +  +     +A +  G +    K ++   A +AE    + +      
Sbjct: 1093 QRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVART 1152

Query: 195  ---KYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRR---KENEIELSLL 248
               K    L EE       LE+ + S   Q +EL    E   T+L++   +E  I  + +
Sbjct: 1153 KAEKQRRDLGEELEALRGELEDTLDSTNAQ-QELRSKREQEVTELKKTLEEETRIHEAAV 1211

Query: 249  QLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMA 308
            Q   Q+       + + +E  +  K   EK+    A+E +  +L+ +  +L+ +      
Sbjct: 1212 QELRQRHGQALGELAEQLEQARRGKGAWEKTRL--ALEAEVSELRAELSSLQTARQEGEQ 1269

Query: 309  NGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDS 368
                L +QL+E + +    E+         +R +   + ++    E E       K   S
Sbjct: 1270 RRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSS 1329

Query: 369  AFSAAHEEQWKLKEQ-QLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENREL 427
              +  H+ Q  L+E+ + K+ +     A++++     E L+     R+      +  REL
Sbjct: 1330 TEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARE------RAGREL 1383

Query: 428  QLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEI 487
            Q      + QL E ++R     QE +  A E  E      A++ +    L+  +   +E 
Sbjct: 1384 Q----TAQAQLSEWRRR-----QEEEAGALEAGEEARRRAAREAEA---LTQRLAEKTET 1431

Query: 488  NKDLERSMRELQATHAETVQELEKTRNMLI----MQHKINKDYQMEVEAVTRKMENLQQD 543
               LER  R LQ    +   +LE+ R ++      Q K ++    E  AV R +E  ++ 
Sbjct: 1432 VDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERA 1491

Query: 544  YELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIH-LER 602
                 E+    L +  A   + EA+ +++    +  + + E +   S D+  +++H LER
Sbjct: 1492 EAEGREREARALSLTRALEEEQEAR-EELERQNRALRAELEALL-SSKDDVGKSVHELER 1549

Query: 603  GENLFEIHIN----KVTFSSEVLQASGD 626
               + E   N    +VT   + L A+ D
Sbjct: 1550 ACRVAEQAANDLRAQVTELEDELTAAED 1577



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 125/662 (18%), Positives = 254/662 (38%), Gaps = 107/662 (16%)

Query: 48   EELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVE 107
            +EL     +LHD   LL++  R +     R+          +++ E      +R GR+++
Sbjct: 1325 KELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQ 1384

Query: 108  -----MEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRR 162
                 + E   + +E+   LE   E  +     A ++ +    R         R+  GRR
Sbjct: 1385 TAQAQLSEWRRRQEEEAGALEAGEEARRR----AAREAEALTQRLAEKTETVDRLERGRR 1440

Query: 163  KANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQI 222
            +  +         +    Q   +  T      K+   L EE    +R +E   + +R + 
Sbjct: 1441 RLQQELDDATMDLE----QQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVE---ERERAEA 1493

Query: 223  EELEHLAEIL-------KTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIK----- 270
            E  E  A  L       + Q  R+E E +   L+   +     + ++  +V  ++     
Sbjct: 1494 EGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRV 1553

Query: 271  -------LHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQ--- 320
                   L  Q+ E  + L+A E   ++L+   + L+  H+  +   DE   + + Q   
Sbjct: 1554 AEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAK 1613

Query: 321  RLKCCSLEKQ---------LHSMKFSERRIEEL-----------QDRINDLEKERELLKE 360
            +L+   +E+          + + K  E  +EEL           ++ +  L K +  +KE
Sbjct: 1614 QLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKE 1673

Query: 361  NYDKLYDSA------FSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTER 414
             + ++ ++       FS   E + +LK  + +V        L+ +L        + + +R
Sbjct: 1674 LWREVEETRTSREEIFSQNRESEKRLKGLEAEV------LRLQEELAASDRARRQAQQDR 1727

Query: 415  DQNEKLVQENRELQLQYLEQKQQLD----ELKKRIKLYNQENDINADELSEALLLIKAQK 470
            D+    V      +   LE+K+QL+    +L++ ++     +++  D   + LL +++  
Sbjct: 1728 DEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLT 1787

Query: 471  EQKNGDLSFLVKVDSEINKDLERSMREL-----------QATHAETVQELEKTRNMLIMQ 519
             + + + SF  K +S   + LER ++EL           +A H  T+  LE        Q
Sbjct: 1788 TELSAERSFSAKAESG-RQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQ 1846

Query: 520  HKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQY 579
             +     ++    + R+ E   ++  L+VE+   + D       +L  QL+      KQ 
Sbjct: 1847 LEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVAD-------QLRDQLEKGNLRVKQL 1899

Query: 580  KFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSE-------VLQASGDKEPVTF 632
            K + E       +  +E    + G    +  +  VT S+E        L+    + P+TF
Sbjct: 1900 KRQLE-------EAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTF 1952

Query: 633  CT 634
             T
Sbjct: 1953 TT 1954


>gi|224831241 myosin, heavy chain 14 isoform 3 [Homo sapiens]
          Length = 2036

 Score = 78.2 bits (191), Expect = 5e-14
 Identities = 101/387 (26%), Positives = 180/387 (46%), Gaps = 62/387 (16%)

Query: 207  EIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNV 266
            ++   + V+Q++  ++++++ L +    Q  R+  E++  + QL E++A      +R   
Sbjct: 904  QVTRQDEVLQARAQELQKVQELQQ----QSAREVGELQGRVAQLEEERAR-LAEQLRAEA 958

Query: 267  EMI--------KLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLK 318
            E+         +L  +  E    +S +E +  + +E  R ++     L  +  EL   L+
Sbjct: 959  ELCAEAEETRGRLAARKQELELVVSELEARVGEEEECSRQMQTEKKRLQQHIQELEAHLE 1018

Query: 319  EQRLKCCSLEKQLHSMKFSERRIEE----LQDRINDLEKERELLKENYDKLYDSAFSAAH 374
             +      L+ +  + +   ++ EE    L+D+ + L KER+LL+   D+L + +  AA 
Sbjct: 1019 AEEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLE---DRLAEFSSQAAE 1075

Query: 375  EEQW--KLKEQQLKVQ--IAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQ 430
            EE+    L + +LK +  IA +E  L+ +   + E L++LK   D       E+ ELQ Q
Sbjct: 1076 EEEKVKSLNKLRLKYEATIADMEDRLRKEEKGRQE-LEKLKRRLDG------ESSELQEQ 1128

Query: 431  YLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKD 490
             +EQ+Q+ +EL  R +L  +E     +EL  AL    A+ E + G  + L+K        
Sbjct: 1129 MVEQQQRAEEL--RAQLGRKE-----EELQAAL----ARAEDEGGARAQLLK-------- 1169

Query: 491  LERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKME------NLQQDY 544
               S+RE QA  AE  ++LE  R       K  +D   E+EA+  ++E      N QQ+ 
Sbjct: 1170 ---SLREAQAALAEAQEDLESERVARTKAEKQRRDLGEELEALRGELEDTLDSTNAQQEL 1226

Query: 545  ELKVEQYVHLLD---IRAARIHKLEAQ 568
              K EQ V  L        RIH+   Q
Sbjct: 1227 RSKREQEVTELKKTLEEETRIHEAAVQ 1253



 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 108/489 (22%), Positives = 199/489 (40%), Gaps = 82/489 (16%)

Query: 29   ETSTTRTMKSRQAVSRVSR------EELEDRFLRLHDENIL---LKQHARKQEDKIKRMA 79
            E  T R  +  + V R+ R      +EL+D  + L  +  L   L++  RK +  +    
Sbjct: 1460 EALTQRLAEKTETVDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEK 1519

Query: 80   TKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQ 139
              ++R V +++R E    G +R  R + +   +E+ QE   ELE+QN  L+  L +    
Sbjct: 1520 AAVLRAVEERERAE--AEGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSS 1577

Query: 140  LQTQGYRQTPYNNVQSRINTGRRKANE-NAGLQECPRKGIKFQDAD--VAETPHPMFTKY 196
                G      + ++       + AN+  A + E   +    +DA   +  T   + T++
Sbjct: 1578 KDDVG---KSVHELERACRVAEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQH 1634

Query: 197  GNSLL-EEARGEIRNLENVIQSQRGQIE----------------ELEHLAEILKTQLRRK 239
               L   +  GE R  +   Q +  ++E                +LE   E LK Q+   
Sbjct: 1635 ERDLQGRDEAGEERRRQLAKQLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASA 1694

Query: 240  ENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLV-----EKSNALSAMEGKFIQLQE 294
                E ++ QLR+ QA  Q   +   VE  +  ++ +     E    L  +E + ++LQE
Sbjct: 1695 GQGKEEAVKQLRKMQA--QMKELWREVEETRTSREEIFSQNRESEKRLKGLEAEVLRLQE 1752

Query: 295  KQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKE 354
            +      +      + DE+  ++    L   ++   L   +  E R+ +L++ + + +  
Sbjct: 1753 ELAASDRARRQAQQDRDEMADEVANGNLSKAAI---LEEKRQLEGRLGQLEEELEEEQSN 1809

Query: 355  RELLKENYDKLY------------DSAFSAAHEEQWKLKEQQLKVQIAQLE--------- 393
             ELL + Y KL             + +FSA  E       QQL+ QI +L          
Sbjct: 1810 SELLNDRYRKLLLQVESLTTELSAERSFSAKAES----GRQQLERQIQELRGRLGEEDAG 1865

Query: 394  ---------TALKSDLTDKTEILDRLKTERDQNEKLVQEN----RELQLQYLEQKQQLDE 440
                      AL+S L    E L++   ER  + KLV+      +E+ LQ  E+++  D+
Sbjct: 1866 ARARHKMTIAALESKLAQAEEQLEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVADQ 1925

Query: 441  LKKRIKLYN 449
            L+ +++  N
Sbjct: 1926 LRDQLEKGN 1934



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 125/628 (19%), Positives = 249/628 (39%), Gaps = 59/628 (9%)

Query: 29   ETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVND 88
            E    + ++  +  +    ++ E+  L L D+N  L +  +  ED++   +++       
Sbjct: 1020 EEGARQKLQLEKVTTEAKMKKFEEDLLLLEDQNSKLSKERKLLEDRLAEFSSQAAEEEEK 1079

Query: 89   KKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQ- 147
             K   ++     RL  +  + +M ++L+ K  +  ++ E LK RL     +LQ Q   Q 
Sbjct: 1080 VKSLNKL-----RLKYEATIADMEDRLR-KEEKGRQELEKLKRRLDGESSELQEQMVEQQ 1133

Query: 148  -------TPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFT------ 194
                         +  +     +A +  G +    K ++   A +AE    + +      
Sbjct: 1134 QRAEELRAQLGRKEEELQAALARAEDEGGARAQLLKSLREAQAALAEAQEDLESERVART 1193

Query: 195  ---KYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRR---KENEIELSLL 248
               K    L EE       LE+ + S   Q +EL    E   T+L++   +E  I  + +
Sbjct: 1194 KAEKQRRDLGEELEALRGELEDTLDSTNAQ-QELRSKREQEVTELKKTLEEETRIHEAAV 1252

Query: 249  QLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMA 308
            Q   Q+       + + +E  +  K   EK+    A+E +  +L+ +  +L+ +      
Sbjct: 1253 QELRQRHGQALGELAEQLEQARRGKGAWEKTRL--ALEAEVSELRAELSSLQTARQEGEQ 1310

Query: 309  NGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDS 368
                L +QL+E + +    E+         +R +   + ++    E E       K   S
Sbjct: 1311 RRRRLELQLQEVQGRAGDGERARAEAAEKLQRAQAELENVSGALNEAESKTIRLSKELSS 1370

Query: 369  AFSAAHEEQWKLKEQ-QLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENREL 427
              +  H+ Q  L+E+ + K+ +     A++++     E L+     R+      +  REL
Sbjct: 1371 TEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARE------RAGREL 1424

Query: 428  QLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEI 487
            Q      + QL E ++R     QE +  A E  E      A++ +    L+  +   +E 
Sbjct: 1425 Q----TAQAQLSEWRRR-----QEEEAGALEAGEEARRRAAREAEA---LTQRLAEKTET 1472

Query: 488  NKDLERSMRELQATHAETVQELEKTRNMLI----MQHKINKDYQMEVEAVTRKMENLQQD 543
               LER  R LQ    +   +LE+ R ++      Q K ++    E  AV R +E  ++ 
Sbjct: 1473 VDRLERGRRRLQQELDDATMDLEQQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVEERERA 1532

Query: 544  YELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIH-LER 602
                 E+    L +  A   + EA+ +++    +  + + E +   S D+  +++H LER
Sbjct: 1533 EAEGREREARALSLTRALEEEQEAR-EELERQNRALRAELEALL-SSKDDVGKSVHELER 1590

Query: 603  GENLFEIHIN----KVTFSSEVLQASGD 626
               + E   N    +VT   + L A+ D
Sbjct: 1591 ACRVAEQAANDLRAQVTELEDELTAAED 1618



 Score = 62.4 bits (150), Expect = 3e-09
 Identities = 125/662 (18%), Positives = 254/662 (38%), Gaps = 107/662 (16%)

Query: 48   EELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVE 107
            +EL     +LHD   LL++  R +     R+          +++ E      +R GR+++
Sbjct: 1366 KELSSTEAQLHDAQELLQEETRAKLALGSRVRAMEAEAAGLREQLEEEAAARERAGRELQ 1425

Query: 108  -----MEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRR 162
                 + E   + +E+   LE   E  +     A ++ +    R         R+  GRR
Sbjct: 1426 TAQAQLSEWRRRQEEEAGALEAGEEARRR----AAREAEALTQRLAEKTETVDRLERGRR 1481

Query: 163  KANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQI 222
            +  +         +    Q   +  T      K+   L EE    +R +E   + +R + 
Sbjct: 1482 RLQQELDDATMDLE----QQRQLVSTLEKKQRKFDQLLAEEKAAVLRAVE---ERERAEA 1534

Query: 223  EELEHLAEIL-------KTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIK----- 270
            E  E  A  L       + Q  R+E E +   L+   +     + ++  +V  ++     
Sbjct: 1535 EGREREARALSLTRALEEEQEAREELERQNRALRAELEALLSSKDDVGKSVHELERACRV 1594

Query: 271  -------LHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQ--- 320
                   L  Q+ E  + L+A E   ++L+   + L+  H+  +   DE   + + Q   
Sbjct: 1595 AEQAANDLRAQVTELEDELTAAEDAKLRLEVTVQALKTQHERDLQGRDEAGEERRRQLAK 1654

Query: 321  RLKCCSLEKQ---------LHSMKFSERRIEEL-----------QDRINDLEKERELLKE 360
            +L+   +E+          + + K  E  +EEL           ++ +  L K +  +KE
Sbjct: 1655 QLRDAEVERDEERKQRTLAVAARKKLEGELEELKAQMASAGQGKEEAVKQLRKMQAQMKE 1714

Query: 361  NYDKLYDSA------FSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTER 414
             + ++ ++       FS   E + +LK  + +V        L+ +L        + + +R
Sbjct: 1715 LWREVEETRTSREEIFSQNRESEKRLKGLEAEV------LRLQEELAASDRARRQAQQDR 1768

Query: 415  DQNEKLVQENRELQLQYLEQKQQLD----ELKKRIKLYNQENDINADELSEALLLIKAQK 470
            D+    V      +   LE+K+QL+    +L++ ++     +++  D   + LL +++  
Sbjct: 1769 DEMADEVANGNLSKAAILEEKRQLEGRLGQLEEELEEEQSNSELLNDRYRKLLLQVESLT 1828

Query: 471  EQKNGDLSFLVKVDSEINKDLERSMREL-----------QATHAETVQELEKTRNMLIMQ 519
             + + + SF  K +S   + LER ++EL           +A H  T+  LE        Q
Sbjct: 1829 TELSAERSFSAKAESG-RQQLERQIQELRGRLGEEDAGARARHKMTIAALESKLAQAEEQ 1887

Query: 520  HKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQY 579
             +     ++    + R+ E   ++  L+VE+   + D       +L  QL+      KQ 
Sbjct: 1888 LEQETRERILSGKLVRRAEKRLKEVVLQVEEERRVAD-------QLRDQLEKGNLRVKQL 1940

Query: 580  KFKPEIMPDDSVDEFDETIHLERGENLFEIHINKVTFSSE-------VLQASGDKEPVTF 632
            K + E       +  +E    + G    +  +  VT S+E        L+    + P+TF
Sbjct: 1941 KRQLE-------EAEEEASRAQAGRRRLQRELEDVTESAESMNREVTTLRNRLRRGPLTF 1993

Query: 633  CT 634
             T
Sbjct: 1994 TT 1995


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 78.2 bits (191), Expect = 5e-14
 Identities = 143/666 (21%), Positives = 265/666 (39%), Gaps = 141/666 (21%)

Query: 28   QETSTTRTMKSRQAVSRVSREELEDRFLRLHDENILLKQHARKQEDKIKRMATKLIRLVN 87
            +E    + ++  +  +    +++E+  L L D+N    +  +  ED+I   +++L     
Sbjct: 961  EEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEE 1020

Query: 88   DKKRYERVGGGPKRLGRDVE----MEEMIEQ---------------LQEKVHELEKQNET 128
              K   ++    + +  D+E     EE   Q               LQ+++ EL+ Q + 
Sbjct: 1021 KAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDE 1080

Query: 129  LKNRLISAKQQLQ---TQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADV 185
            LK +L   +++LQ    +G  +T + N  + +   R    + A LQE         D + 
Sbjct: 1081 LKLQLAKKEEELQGALARGDDETLHKN--NALKVVRELQAQIAELQE---------DFES 1129

Query: 186  AETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIE---ELEHLAEILKTQLRRKENE 242
             +       K    L EE       LE+ + +   Q E   + E     LK  L  +   
Sbjct: 1130 EKASRNKAEKQKRDLSEELEALKTELEDTLDTTAAQQELRTKREQEVAELKKALEEETKN 1189

Query: 243  IELSLLQLREQQAT---------DQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQ-- 291
             E  +  +R++ AT         +Q    + N+E    +KQ +E  N   A E K +Q  
Sbjct: 1190 HEAQIQDMRQRHATALEELSEQLEQAKRFKANLEK---NKQGLETDNKELACEVKVLQQV 1246

Query: 292  ---LQEKQRTLRISHDAL---MANGDELNMQLKEQRLK---------------------- 323
                + K++ L      L   ++ GD L ++L E+  K                      
Sbjct: 1247 KAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKASKLQNELDNVSTLLEEAEKKGIKF 1306

Query: 324  ---CCSLEKQLHS----MKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEE 376
                 SLE QL      ++   R+   L  RI  LE+E+  L+E  ++  ++  +   + 
Sbjct: 1307 AKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKNSLQEQQEEEEEARKNLEKQV 1366

Query: 377  ---QWKLKEQQLKVQ-----IAQLETALKSDLTDKTEILDRL--------KTERDQNEKL 420
               Q +L + + KV      I  LE A K  L D   +  RL        K E+ +N +L
Sbjct: 1367 LALQSQLADTKKKVDDDLGTIESLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKN-RL 1425

Query: 421  VQENRELQLQYLEQKQQLDELKKRIKLYNQ----ENDINA--------------DELSEA 462
             QE  +L +    Q+Q    L+K+ K ++Q    E  I+A              ++ ++A
Sbjct: 1426 QQELDDLTVDLDHQRQVASNLEKKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKA 1485

Query: 463  LLLIKA-------------QKEQKNGDLSFLVKVDSEINK---DLERSMRELQATHAETV 506
            L L +A             Q +Q   D+  L+    ++ K   +LE+S R L+    E  
Sbjct: 1486 LSLARALEEALEAKEEFERQNKQLRADMEDLMSSKDDVGKNVHELEKSKRALEQQVEEMR 1545

Query: 507  QELEKTRNMLIMQHKINKDYQMEVEAVTRKME-NLQQDYELKVEQYVHLLDIRAARIHKL 565
             +LE+  + L    +  +D ++ +E   + M+   ++D + + EQ      +   ++ +L
Sbjct: 1546 TQLEELEDEL----QATEDAKLRLEVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVREL 1601

Query: 566  EAQLKD 571
            EA+L+D
Sbjct: 1602 EAELED 1607



 Score = 77.0 bits (188), Expect = 1e-13
 Identities = 117/523 (22%), Positives = 224/523 (42%), Gaps = 86/523 (16%)

Query: 56   RLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVE-MEEMIEQ 114
            R  +E    +  AR++E K   +A  L   +  K+ +ER     K+L  D+E +    + 
Sbjct: 1466 RYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQN---KQLRADMEDLMSSKDD 1522

Query: 115  LQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQ-EC 173
            + + VHELEK    L+ ++   + QL+           ++  +     +A E+A L+ E 
Sbjct: 1523 VGKNVHELEKSKRALEQQVEEMRTQLE----------ELEDEL-----QATEDAKLRLEV 1567

Query: 174  PRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILK 233
              + +K Q                              E  +Q++  Q EE + L     
Sbjct: 1568 NMQAMKAQ-----------------------------FERDLQTRDEQNEEKKRL----- 1593

Query: 234  TQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQ 293
              L ++  E+E  L   R+Q+A    S  +  +++  L  Q+   + A   +  +  +LQ
Sbjct: 1594 --LIKQVRELEAELEDERKQRALAVASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQ 1651

Query: 294  EKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEK 353
             + +  +   +   A+ DE+  Q KE        EK+L S+   E  I +LQ+ +   E+
Sbjct: 1652 AQMKDYQRELEEARASRDEIFAQSKES-------EKKLKSL---EAEILQLQEELASSER 1701

Query: 354  ERELLKENYDKLYDSAFSAAHEEQWKLKE-QQLKVQIAQLETALKSDLTDKTEILDRLKT 412
             R   ++  D+L D   ++A  +   L E ++L+ +IAQLE  L+ + ++   + DR + 
Sbjct: 1702 ARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEELEEEQSNMELLNDRFRK 1761

Query: 413  ERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQ 472
               Q + L   N EL  +     Q+ D  +++++  N+E      EL  A+      K +
Sbjct: 1762 TTLQVDTL---NAELAAE-RSAAQKSDNARQQLERQNKELKAKLQELEGAV------KSK 1811

Query: 473  KNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINK----DYQM 528
                +S L     ++ + LE+  +E  A + + V+  EK    + MQ +  +     Y+ 
Sbjct: 1812 FKATISALEAKIGQLEEQLEQEAKERAAAN-KLVRRTEKKLKEIFMQVEDERRHADQYKE 1870

Query: 529  EVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKD 571
            ++E    +M+ L++  E   E+        A+R  KL+ +L D
Sbjct: 1871 QMEKANARMKQLKRQLEEAEEEATR---ANASR-RKLQRELDD 1909



 Score = 74.3 bits (181), Expect = 7e-13
 Identities = 114/521 (21%), Positives = 213/521 (40%), Gaps = 83/521 (15%)

Query: 101  RLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQL-----QTQGYRQTPYNNVQS 155
            R  R+ E+ E+ + L+E+    E Q + ++ R  +A ++L     Q + ++     N Q 
Sbjct: 1169 RTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLEKNKQG 1228

Query: 156  RINTGRRKANENAGLQECPRKGI---KFQDADVAETPHPMFTKYGNSLLEEARGEIRNLE 212
                 +  A E   LQ+   +     K  DA V E  H   ++ G+ L  E   +   L+
Sbjct: 1229 LETDNKELACEVKVLQQVKAESEHKRKKLDAQVQEL-HAKVSE-GDRLRVELAEKASKLQ 1286

Query: 213  NVIQSQRGQIEE------------------LEHLAEILKTQLRRKEN------EIELSLL 248
            N + +    +EE                  L+   E+L+ + R+K N      ++E    
Sbjct: 1287 NELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSSRIRQLEEEKN 1346

Query: 249  QLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMA 308
             L+EQQ  ++ +      +++ L  QL +    +    G    L+E ++ L       + 
Sbjct: 1347 SLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIESLEEAKKKL-------LK 1399

Query: 309  NGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLK--ENYDKLY 366
            + + L+ +L+E+ L    LEK  + ++      +EL D   DL+ +R++    E   K +
Sbjct: 1400 DAEALSQRLEEKALAYDKLEKTKNRLQ------QELDDLTVDLDHQRQVASNLEKKQKKF 1453

Query: 367  D---------SAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQN 417
            D         SA  A   ++ + + ++ + +   L  AL+  L  K E   + K  R   
Sbjct: 1454 DQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNKQLRADM 1513

Query: 418  EKLVQEN-------RELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQK 470
            E L+           EL+      +QQ++E++ +++    E     D      + ++A K
Sbjct: 1514 EDLMSSKDDVGKNVHELEKSKRALEQQVEEMRTQLEELEDELQATEDAKLRLEVNMQAMK 1573

Query: 471  EQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEV 530
             Q   DL    + + E  + L + +REL+A       ELE  R    +            
Sbjct: 1574 AQFERDLQTRDEQNEEKKRLLIKQVRELEA-------ELEDERKQRAL-----------A 1615

Query: 531  EAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKD 571
             A  +KME   +D E ++E      D    ++ KL+AQ+KD
Sbjct: 1616 VASKKKMEIDLKDLEAQIEAANKARDEVIKQLRKLQAQMKD 1656



 Score = 67.8 bits (164), Expect = 6e-11
 Identities = 119/552 (21%), Positives = 230/552 (41%), Gaps = 80/552 (14%)

Query: 44   RVSREELEDRFLRLHDENIL-LKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRL 102
            +V+R+E E   L+  DE +L +K+   K E +++ M  K  +L+ +K            L
Sbjct: 846  QVTRQEEE---LQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQAETEL 902

Query: 103  GRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRR 162
                E EEM  +L  K  ELE+    L++R+   +++ Q     Q     +Q+ I     
Sbjct: 903  F--AEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQ---ILQNEKKKMQAHIQDLEE 957

Query: 163  KANENAGLQE-------CPRKGIKFQDADV--AETPHPMFTKYG----------NSLLEE 203
            + +E  G ++            IK  + ++   E  +  F K            +S L E
Sbjct: 958  QLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAE 1017

Query: 204  ARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQATDQRSNIR 263
               + +NL  +   Q   I +LE    + K +  R+E E     L        DQ + ++
Sbjct: 1018 EEEKAKNLAKIRNKQEVMISDLEE--RLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQ 1075

Query: 264  DNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLK 323
              ++ +KL  QL +K              +E Q  L    D  +   + L + ++E + +
Sbjct: 1076 AQIDELKL--QLAKKE-------------EELQGALARGDDETLHKNNALKV-VRELQAQ 1119

Query: 324  CCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQ 383
               L++   S K S  + E+ +    DL +E E LK    +L D+  + A +++ + K +
Sbjct: 1120 IAELQEDFESEKASRNKAEKQK---RDLSEELEALK---TELEDTLDTTAAQQELRTKRE 1173

Query: 384  QLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKK 443
            Q   ++A+L+ AL+               E   +E  +Q+ R+     LE+  +  E  K
Sbjct: 1174 Q---EVAELKKALEE--------------ETKNHEAQIQDMRQRHATALEELSEQLEQAK 1216

Query: 444  RIKLYNQEN----DINADELS---EALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMR 496
            R K   ++N    + +  EL+   + L  +KA+ E K   L   V+       + +R   
Sbjct: 1217 RFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRV 1276

Query: 497  ELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLD 556
            EL    ++   EL+    +L    K    +  +  ++  ++++ Q+  + +  Q ++L  
Sbjct: 1277 ELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNL-- 1334

Query: 557  IRAARIHKLEAQ 568
              ++RI +LE +
Sbjct: 1335 --SSRIRQLEEE 1344



 Score = 64.3 bits (155), Expect = 7e-10
 Identities = 96/430 (22%), Positives = 188/430 (43%), Gaps = 71/430 (16%)

Query: 201  LEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQ-QATDQR 259
            +E    ++   +N++  Q     EL   AE ++ +L  K+ E+E  L  L  + +  ++R
Sbjct: 878  MERKHQQLLEEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEER 937

Query: 260  SNIRDNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRT----LRISHDALMANGDELNM 315
            + I  N E  K+   + +    L   EG   +LQ ++ T    ++   + ++   D+ + 
Sbjct: 938  NQILQN-EKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQNSK 996

Query: 316  QLKEQRL------KCCSL-----EKQLHSMKFSERR---IEELQDRINDLEKERELLKEN 361
             +KE++L      +C S      EK  +  K   ++   I +L++R+   EK R+ L++ 
Sbjct: 997  FIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKA 1056

Query: 362  YDKLYDSAFSAAHEEQWKLKEQ--QLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEK 419
              KL D   +   ++  +L+ Q  +LK+Q+A+ E  L+  L             R  +E 
Sbjct: 1057 KRKL-DGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALA------------RGDDET 1103

Query: 420  LVQEN-----RELQLQYLEQKQQLD-ELKKRIKLYNQENDINAD------ELSEALLLIK 467
            L + N     RELQ Q  E ++  + E   R K   Q+ D++ +      EL + L    
Sbjct: 1104 LHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLDTTA 1163

Query: 468  AQKE---QKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQE---------------- 508
            AQ+E   ++  +++ L K   E  K+ E  +++++  HA  ++E                
Sbjct: 1164 AQQELRTKREQEVAELKKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFKANLE 1223

Query: 509  -----LEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIH 563
                 LE     L  + K+ +  + E E   +K++   Q+   KV +   L    A +  
Sbjct: 1224 KNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRVELAEKAS 1283

Query: 564  KLEAQLKDIA 573
            KL+ +L +++
Sbjct: 1284 KLQNELDNVS 1293


>gi|6715600 golgi autoantigen, golgin subfamily a, 4 [Homo sapiens]
          Length = 2230

 Score = 78.2 bits (191), Expect = 5e-14
 Identities = 124/578 (21%), Positives = 250/578 (43%), Gaps = 94/578 (16%)

Query: 58   HDENILLKQH----ARKQEDKIKRMATKLIRLVND-----------KKRYERVGGGPKRL 102
            H E +   QH      ++++++K    K++ L N            KK  E V    K  
Sbjct: 1559 HKELVQKLQHFQELGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKSK 1618

Query: 103  GRDVE-MEEMIE-----QLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSR 156
              +++ +E+ +E     +L E   + E++   +K +L+S  ++ + Q Y++   +++ S 
Sbjct: 1619 EEELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQ-YKKGTESHL-SE 1676

Query: 157  INTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEA--RGEIRNL--E 212
            +NT  ++      + E   K ++   ++    P         +  EEA  +G ++    E
Sbjct: 1677 LNTKLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEE 1736

Query: 213  NVIQSQRGQIEELEHLAEILKTQLRRKENEIELS------LLQLREQQATDQRSNIRDNV 266
             +   QR   E+ + L  + + +     +  E+       L++L   +A        D  
Sbjct: 1737 KISVLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHE----DQS 1792

Query: 267  EMIKLHKQLVEKSNALSAMEGKFIQ-------LQEKQRTLRISHDALMANGD-ELNMQLK 318
             +  L ++L EK+   S +  + ++       +Q KQ    +  D      + EL  Q+ 
Sbjct: 1793 MIGHLQEELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQIL 1852

Query: 319  EQRLK----CCSLEKQLHSMKFSE--RRIEELQ--DRINDLEKERELLKENYDKLYDSAF 370
            EQ++K    C   +K++H ++  E   + E+LQ   +++   K  ELL+EN ++      
Sbjct: 1853 EQKIKELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEK----- 1907

Query: 371  SAAHEEQWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQ 430
            S +H  Q KL    ++ Q   LE  L     +K ++           +++V+  ++L++ 
Sbjct: 1908 SKSHLVQPKLLSN-MEAQHNDLEFKLAGAEREKQKL----------GKEIVRLQKDLRML 1956

Query: 431  YLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKD 490
              E +Q+L+ LKK    Y+QE +    +  E L L      + N  L  L++   E N  
Sbjct: 1957 RKEHQQELEILKKE---YDQEREEKIKQEQEDLEL------KHNSTLKQLMR---EFNTQ 2004

Query: 491  LERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQ 550
            L +  +EL+ T  ET+ + ++    L+  H      Q E   + +K+     D +   ++
Sbjct: 2005 LAQKEQELEMTIKETINKAQEVEAELLESH------QEETNQLLKKIAEKDDDLKRTAKR 2058

Query: 551  YVHLLDIR----AARIHKLEAQLKDIAYGTKQYKFKPE 584
            Y  +LD R     A++  L+ QL+++    K+Y+ K E
Sbjct: 2059 YEEILDAREEEMTAKVRDLQTQLEEL---QKKYQQKLE 2093



 Score = 75.1 bits (183), Expect = 4e-13
 Identities = 110/522 (21%), Positives = 236/522 (45%), Gaps = 79/522 (15%)

Query: 104  RDVEMEEMIEQLQEKV---HELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTG 160
            +  E+E +  +L E +   H+LE++   LK++    KQ+L+ +   Q   N+ Q ++++ 
Sbjct: 682  KQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQK--NHHQQQVDSI 739

Query: 161  RRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRG 220
             ++   +    E   K +K Q   +      +  K  +  L+E +  + NLE  I+   G
Sbjct: 740  IKEHEVSIQRTE---KALKDQINQLE-----LLLKERDKHLKEHQAHVENLEADIKRSEG 791

Query: 221  QIEELEHLAEILK-----TQLRRKENEIELSLLQ-----------LREQQATDQRSNIRD 264
            ++++     ++ +     T  + K  E +L+ LQ           L  +Q  +  +  +D
Sbjct: 792  ELQQASAKLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQVAEVEAQKKD 851

Query: 265  NVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKE----- 319
                +  HK  ++  + +  +E +  ++++K ++L   +++ + +G++   Q K+     
Sbjct: 852  VCTELDAHK--IQVQDLMQQLEKQNSEMEQKVKSLTQVYESKLEDGNKEQEQTKQILVEK 909

Query: 320  QRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWK 379
            + +     E Q   ++   +++   +D I+ L +E E   +N +K  +     A E Q  
Sbjct: 910  ENMILQMREGQKKEIEILTQKLSAKEDSIHILNEEYETKFKNQEKKMEKVKQKAKEMQET 969

Query: 380  LK----EQQLKVQIAQLETALKSDLTDK-----------------TEILDRLKT-ERDQN 417
            LK    +Q+ K++     TAL+    +K                 ++ + RL+T +++Q 
Sbjct: 970  LKKKLLDQEAKLKKELENTALELSQKEKQFNAKMLEMAQANSAGISDAVSRLETNQKEQI 1029

Query: 418  EKLVQ-ENRELQ--LQYLEQK--QQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQ 472
            E L +   REL   +   E+K  QQ +EL++  ++  QE +    EL + +LL   +KE+
Sbjct: 1030 ESLTEVHRRELNDVISIWEKKLNQQAEELQEIHEIQLQEKEQEVAELKQKILLFGCEKEE 1089

Query: 473  KNGDLSFL----VKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQM 528
             N ++++L    VK D+ +N +L+  +++  A      Q+  K +  L    K+  D   
Sbjct: 1090 MNKEITWLKEEGVKQDTTLN-ELQEQLKQKSAHVNSLAQDETKLKAHL---EKLEVDLNK 1145

Query: 529  EVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLK 570
             ++  T   E L    ELK+     L +    ++ +L ++LK
Sbjct: 1146 SLKENTFLQEQL---VELKM-----LAEEDKRKVSELTSKLK 1179



 Score = 69.3 bits (168), Expect = 2e-11
 Identities = 125/623 (20%), Positives = 251/623 (40%), Gaps = 93/623 (14%)

Query: 15   KDTGLNLFGMGGLQETSTTRTMKSRQAVSRVSREELE---DRFLR----LHDENILLKQH 67
            +DT LN       Q+++   ++   +   +   E+LE   ++ L+    L ++ + LK  
Sbjct: 1104 QDTTLNELQEQLKQKSAHVNSLAQDETKLKAHLEKLEVDLNKSLKENTFLQEQLVELKML 1163

Query: 68   ARKQEDKIKRMATKLIRLVND----KKRYERVGGGPKRLGRDVEMEEMIEQLQEKVHELE 123
            A + + K+  + +KL     +    K  +E+     +   + +E +++ E+L  ++    
Sbjct: 1164 AEEDKRKVSELTSKLKTTDEEFQSLKSSHEKSNKSLE--DKSLEFKKLSEELAIQLDICC 1221

Query: 124  KQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRR---KANENAGLQECPRKGIKF 180
            K+ E L    + AK   +      +  N + SRI+  +    K  E   ++ C    ++ 
Sbjct: 1222 KKTEAL----LEAKTN-ELINISSSKTNAILSRISHCQHRTTKVKEALLIKTCTVSELEA 1276

Query: 181  QDADVAETPHPMFTKYGNSLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLRRKE 240
            Q   + E  + +     N   ++A  ++   EN I+S +  IE L     + + +  +KE
Sbjct: 1277 QLRQLTEEQNTL-----NISFQQATHQLEEKENQIKSMKADIESL-----VTEKEALQKE 1326

Query: 241  NEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQ-LVEKSNALSAMEGKF---------- 289
               +      +E   T  +  + +N+  + L K+ L EK   +S++  +           
Sbjct: 1327 GGNQQQAASEKESCITQLKKELSENINAVTLMKEELKEKKVEISSLSKQLTDLNVQLQNS 1386

Query: 290  IQLQEKQRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSM---------KFSERR 340
            I L EK+  +            EL  Q+++   K  +L K+  S          KFSE +
Sbjct: 1387 ISLSEKEAAISSLRKQYDEEKCELLDQVQDLSFKVDTLSKEKISALEQVDDWSNKFSEWK 1446

Query: 341  -------------IEELQDRINDLEKER-------ELLKENYD---KLYDSAFSAAHEEQ 377
                         ++ELQ ++    KE         LLKE  D   K +D       +++
Sbjct: 1447 KKAQSRFTQHQNTVKELQIQLELKSKEAYEKDEQINLLKEELDQQNKRFDCLKGEMEDDK 1506

Query: 378  WKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTE----RDQNEKLVQENRELQLQYLE 433
             K+++++     + LET LKS      E+ D +  +       NE L   N++  +++ E
Sbjct: 1507 SKMEKKE-----SNLETELKSQTARIMELEDHITQKTIEIESLNEVLKNYNQQKDIEHKE 1561

Query: 434  QKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLER 493
              Q+L   ++      +E D    E  E +L ++ Q      +L    K    +N  ++ 
Sbjct: 1562 LVQKLQHFQE----LGEEKDNRVKEAEEKILTLENQVYSMKAELETKKKELEHVNLSVKS 1617

Query: 494  SMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVH 553
               EL+A   E   E E    +  ++ K  +      + +  +ME  ++ Y+   E ++ 
Sbjct: 1618 KEEELKA--LEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLS 1675

Query: 554  LLDI----RAARIHKLEAQLKDI 572
             L+     R   +H LE +LK +
Sbjct: 1676 ELNTKLQEREREVHILEEKLKSV 1698



 Score = 67.8 bits (164), Expect = 6e-11
 Identities = 122/590 (20%), Positives = 245/590 (41%), Gaps = 86/590 (14%)

Query: 56  RLHDENILLKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDVEMEEMIEQL 115
           ++H+   + ++   +   +IK+M T+   L   K++ ER     + L + +   +  E+ 
Sbjct: 372 QMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAF--EELEKALSTAQKTEEA 429

Query: 116 QEKVH-ELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANEN--AGLQE 172
           + K+  E+++Q +T++      +  LQ +       + V+  +    +K++E   A LQ+
Sbjct: 430 RRKLKAEMDEQIKTIEKTSEEERISLQQE------LSRVKQEVVDVMKKSSEEQIAKLQK 483

Query: 173 CPRKGIKFQDADVA---ETPHPMFTKYGNSLLEEARGEIRNLEN---------------- 213
              K +  ++ ++    +T    F +     LE+++ E   +                  
Sbjct: 484 LHEKELARKEQELTKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQ 543

Query: 214 ---VIQSQRGQIEELEHLAEILKTQLRRKENEIELSLLQLREQQA-------TDQRSNIR 263
              ++     ++ +L+  AE  +T++   E+ +E SL + + Q          ++  + +
Sbjct: 544 KKAILTESENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNK 603

Query: 264 DNVEMIKLHKQLVEKSNALSAMEGKFIQLQEKQRTLRISHDALMANGDELNMQLKEQRLK 323
           +   M++ HK  +E     S    +     EK + L+  +   M    E   Q KE  LK
Sbjct: 604 EITVMVEKHKTELE-----SLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLK 658

Query: 324 CCSLEKQLHSMKFSERRIEELQDRINDLE----------KERELLKENYDKLYDSAFSAA 373
              +  Q H  + +E+ +E+L  +  +LE          K R  L+E    L D      
Sbjct: 659 DKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEELSVLKDQTDKMK 718

Query: 374 HEEQWKLKEQ-------------QLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKL 420
            E + K+ EQ             + +V I + E ALK    D+   L+ L  ERD++ K 
Sbjct: 719 QELEAKMDEQKNHHQQQVDSIIKEHEVSIQRTEKALK----DQINQLELLLKERDKHLKE 774

Query: 421 VQENRE-LQLQYLEQKQQLDELKKRIKLYNQENDINADELSEALLLIKAQKEQKNGDLS- 478
            Q + E L+      + +L +   ++ ++ Q       E ++A     AQ +QK  DL  
Sbjct: 775 HQAHVENLEADIKRSEGELQQASAKLDVF-QSYQSATHEQTKAYEEQLAQLQQKLLDLET 833

Query: 479 ---FLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTR 535
               L K  +E+    +    EL A H   VQ+L      +    K N + + +V+++T+
Sbjct: 834 ERILLTKQVAEVEAQKKDVCTELDA-HKIQVQDL------MQQLEKQNSEMEQKVKSLTQ 886

Query: 536 KMENLQQDYELKVEQYVHLLDIRAARIHKL-EAQLKDIAYGTKQYKFKPE 584
             E+  +D   + EQ   +L  +   I ++ E Q K+I   T++   K +
Sbjct: 887 VYESKLEDGNKEQEQTKQILVEKENMILQMREGQKKEIEILTQKLSAKED 936



 Score = 64.7 bits (156), Expect = 5e-10
 Identities = 124/618 (20%), Positives = 248/618 (40%), Gaps = 130/618 (21%)

Query: 107 EMEEMIEQLQEKVHELEKQNE---TLKNRLI-----------------------SAKQQL 140
           E E + EQL E++ ELEK  +     K +LI                       + +Q  
Sbjct: 315 EKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRDAKNLIEQLEQDKGMVIAETKRQMH 374

Query: 141 QTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIK--FQDADVAETPHPMFTKYGN 198
           +T   ++     ++SRI   ++   +   L+E   K  +  F++ + A +      +   
Sbjct: 375 ETLEMKEEEIAQLRSRI---KQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARR 431

Query: 199 SLLEEARGEIRNLENVIQSQRGQI--------------------EELEHLAEILKTQLRR 238
            L  E   +I+ +E   + +R  +                    E++  L ++ + +L R
Sbjct: 432 KLKAEMDEQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQKLHEKELAR 491

Query: 239 KENEIELSLLQLREQQATDQR--------------SNIRDNVEMIKLHKQLVEKSNALSA 284
           KE E+    LQ RE++  +Q               S  ++  E + L +  ++K   L+ 
Sbjct: 492 KEQEL-TKKLQTREREFQEQMKVALEKSQSEYLKISQEKEQQESLALEELELQKKAILTE 550

Query: 285 MEGKFIQLQEKQRTLRI-------------------SHDALMANGDELNMQLKEQRLKCC 325
            E K   LQ++  T R                    S D  +    E N   KE  +   
Sbjct: 551 SENKLRDLQQEAETYRTRILELESSLEKSLQENKNQSKDLAVHLEAEKNKHNKEITVMVE 610

Query: 326 SLEKQLHSMKFSERRI---------EELQDRINDLEKERELLKENYDKLYDSAFSAAHEE 376
             + +L S+K  +  +         ++ Q  +  L ++ E  KE   K  +  F A  EE
Sbjct: 611 KHKTELESLKHQQDALWTEKLQVLKQQYQTEMEKLREKCEQEKETLLKDKEIIFQAHIEE 670

Query: 377 QWKLKEQQLKVQIAQLETALKSDLTDKTEILDRLKTE----RDQNEKLVQE-NRELQLQY 431
             +   ++L V+  +LE +L S+L++  +   +L+ E    +DQ +K+ QE   ++  Q 
Sbjct: 671 MNEKTLEKLDVKQTELE-SLSSELSEVLKARHKLEEELSVLKDQTDKMKQELEAKMDEQK 729

Query: 432 LEQKQQLDELKKRIKLYNQEND-INADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKD 490
              +QQ+D + K  ++  Q  +    D++++  LL+K + +      + +  +++    D
Sbjct: 730 NHHQQQVDSIIKEHEVSIQRTEKALKDQINQLELLLKERDKHLKEHQAHVENLEA----D 785

Query: 491 LERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQ 550
           ++RS  ELQ   A    +L+  ++     H+  K Y+ ++  + +K+ +L+ +  L  +Q
Sbjct: 786 IKRSEGELQQASA----KLDVFQSYQSATHEQTKAYEEQLAQLQQKLLDLETERILLTKQ 841

Query: 551 YVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSVDEFDETIHLERGENLFEIH 610
                      + ++EAQ KD+      +K + +          D    LE+  +  E  
Sbjct: 842 -----------VAEVEAQKKDVCTELDAHKIQVQ----------DLMQQLEKQNSEMEQK 880

Query: 611 INKVTFSSEVLQASGDKE 628
           +  +T   E     G+KE
Sbjct: 881 VKSLTQVYESKLEDGNKE 898



 Score = 60.8 bits (146), Expect = 8e-09
 Identities = 98/488 (20%), Positives = 209/488 (42%), Gaps = 63/488 (12%)

Query: 112 IEQLQEKVHELEKQNETLKNRLISAKQQLQTQGYRQTPYNNVQSRINTGRRKANENAGLQ 171
           +E LQ++V    K+ E L  R    K+ +Q+        +  Q  + T  ++A +   L 
Sbjct: 281 LETLQQRV----KRQENLLKR---CKETIQS--------HKEQCTLLTSEKEALQEQ-LD 324

Query: 172 ECPRKGIKFQDADVAETPHPMFTKYGNSLLEEARGEIRNLEN----VIQSQRGQIEELEH 227
           E  ++  K +D  +AE    +      + L +A+  I  LE     VI   + Q+ E   
Sbjct: 325 ERLQELEKIKDLHMAEKTKLI------TQLRDAKNLIEQLEQDKGMVIAETKRQMHETLE 378

Query: 228 LAEILKTQLRRKENEIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNALSAMEG 287
           + E    QLR +  ++     +LREQ+   +R+   +  + +   ++  E    L A   
Sbjct: 379 MKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAFEELEKALSTAQKTEEARRKLKAEMD 438

Query: 288 KFIQLQEK---QRTLRISHDALMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEEL 344
           + I+  EK   +  + +  +      + +++  K    +   L+K LH  + + R+ +EL
Sbjct: 439 EQIKTIEKTSEEERISLQQELSRVKQEVVDVMKKSSEEQIAKLQK-LHEKELA-RKEQEL 496

Query: 345 QDRINDLEKE-RELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLTDK 403
             ++   E+E +E +K   +K        + E     KEQQ  + + +LE   K+ LT+ 
Sbjct: 497 TKKLQTREREFQEQMKVALEKSQSEYLKISQE-----KEQQESLALEELELQKKAILTES 551

Query: 404 TEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQENDINADELSEAL 463
              L                 R+LQ +    + ++ EL+  ++   QEN   + +L+   
Sbjct: 552 ENKL-----------------RDLQQEAETYRTRILELESSLEKSLQENKNQSKDLA--- 591

Query: 464 LLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEKTRNMLIMQHKIN 523
           + ++A+K + N +++ +V+   +   +LE    +  A   E +Q L+  +       K+ 
Sbjct: 592 VHLEAEKNKHNKEITVMVE---KHKTELESLKHQQDALWTEKLQVLK--QQYQTEMEKLR 646

Query: 524 KDYQMEVEAVTRKMENL-QQDYELKVEQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFK 582
           +  + E E + +  E + Q   E   E+ +  LD++   +  L ++L ++     + + +
Sbjct: 647 EKCEQEKETLLKDKEIIFQAHIEEMNEKTLEKLDVKQTELESLSSELSEVLKARHKLEEE 706

Query: 583 PEIMPDDS 590
             ++ D +
Sbjct: 707 LSVLKDQT 714



 Score = 51.2 bits (121), Expect = 6e-06
 Identities = 80/408 (19%), Positives = 170/408 (41%), Gaps = 47/408 (11%)

Query: 29   ETSTTRTMKSRQAVSRVSREELEDRF-LRLHDENILLK-QHARKQEDKIKRMATKLIRLV 86
            + + T   K  Q V +   E +   F +R   +  L+K +HA  ++ + + M   L   +
Sbjct: 1742 QRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQEEL 1801

Query: 87   NDK-KRYERV-------GGGPKRLGRDVEMEEMIEQLQEKVHELEKQNETLKNRLISAKQ 138
             +K K+Y  +        GG   +     +E + + +Q+ + E E   + L+ ++    +
Sbjct: 1802 EEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKI----K 1857

Query: 139  QLQTQGYRQTPYNNVQSRINTGRRKANENAGLQECPRKGIKFQDADVAETPHPMFTKYGN 198
            +L +   RQ   + V+    T + +  +     +   K  +  + +  E       +   
Sbjct: 1858 ELDSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQ--P 1915

Query: 199  SLLEEARGEIRNLENVIQSQRGQIEELEHLAEILKTQLR--RKENEIELSLLQLREQQAT 256
             LL     +  +LE  +     + ++L      L+  LR  RKE++ EL +L+    Q  
Sbjct: 1916 KLLSNMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQER 1975

Query: 257  DQRSNIRDNVEMIKLH-----KQLVEKSNALSAMEGKFIQLQEKQ---RTLRISHDALMA 308
            +++  I+   E ++L      KQL+ + N   A + + +++  K+   +   +  + L +
Sbjct: 1976 EEK--IKQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLES 2033

Query: 309  NGDELNMQLKEQRLKCCSLEKQLHSMK-FSERRIEELQDRINDLEKERELLKENYDKLYD 367
            + +E N  LK+   K   L++     +   + R EE+  ++ DL+ + E L++ Y +  +
Sbjct: 2034 HQEETNQLLKKIAEKDDDLKRTAKRYEEILDAREEEMTAKVRDLQTQLEELQKKYQQKLE 2093

Query: 368  SAFSAAHEE------------------QWKLKEQQLKVQIAQLETALK 397
               +  ++                     KLKEQ+ + QI  LE  LK
Sbjct: 2094 QEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLK 2141



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 118/559 (21%), Positives = 220/559 (39%), Gaps = 108/559 (19%)

Query: 48   EELEDRFLRLHDENIL-LKQHARKQEDKIKRMATKLIRLVNDKKRYERVGGGPKRLGRDV 106
            EEL+    RL  E+   L +  RK E KI  +  +L+  + +K+   + G        + 
Sbjct: 1620 EELKALEDRLESESAAKLAELKRKAEQKIAAIKKQLLSQMEEKEEQYKKGTESHLSELNT 1679

Query: 107  EMEEM---IEQLQEKVHELEK-QNETL------KN-RLISAKQQLQTQGYRQTPYN---N 152
            +++E    +  L+EK+  +E  Q+ETL      KN    + +++  +QG  Q  Y    +
Sbjct: 1680 KLQEREREVHILEEKLKSVESSQSETLIVPRSAKNVAAYTEQEEADSQGCVQKTYEEKIS 1739

Query: 153  VQSRINTGRRKANENAGLQ-------------ECPRKGIKFQDADVAETPHPMFTKYGNS 199
            V  R  T + K  +  G +             +   + IK + A+  +        +   
Sbjct: 1740 VLQRNLTEKEKLLQRVGQEKEETVSSHFEMRCQYQERLIKLEHAEAKQHEDQSMIGHLQE 1799

Query: 200  LLEEARGEI--------------------RNLENVIQSQRGQIEELEHLAEILKTQLRRK 239
             LEE   +                     +NLENV    +  ++E E   +IL+ +++  
Sbjct: 1800 ELEEKNKKYSLIVAQHVEKEGGKNNIQAKQNLENVFDDVQKTLQEKELTCQILEQKIKEL 1859

Query: 240  EN-----------EIELSLLQLREQQATDQRSNIRDNVEMIKLHKQLVEKSNA-----LS 283
            ++           E+E    +  + QA  Q        E+++ + +   KS+      LS
Sbjct: 1860 DSCLVRQKEVHRVEMEELTSKYEKLQALQQMDGRNKPTELLEENTEEKSKSHLVQPKLLS 1919

Query: 284  AMEGK---------------------FIQLQEKQRTLRISHDALMANGDELNMQLKEQRL 322
             ME +                      ++LQ+  R LR  H   +    +   Q +E+++
Sbjct: 1920 NMEAQHNDLEFKLAGAEREKQKLGKEIVRLQKDLRMLRKEHQQELEILKKEYDQEREEKI 1979

Query: 323  KCCSLEKQLHSMKFSERRIEELQDRINDLEKEREL-LKENYDKLYD--SAFSAAHEEQWK 379
            K    + +L      ++ + E   ++   E+E E+ +KE  +K  +  +    +H+E+  
Sbjct: 1980 KQEQEDLELKHNSTLKQLMREFNTQLAQKEQELEMTIKETINKAQEVEAELLESHQEE-- 2037

Query: 380  LKEQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLD 439
                QL  +IA+ +  LK       EILD       + E++  + R+LQ        QL+
Sbjct: 2038 --TNQLLKKIAEKDDDLKRTAKRYEEILDA------REEEMTAKVRDLQ-------TQLE 2082

Query: 440  ELKKRI--KLYNQENDINADELSEALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRE 497
            EL+K+   KL  +EN  N +     L    AQK     D     +   E   +LE  +++
Sbjct: 2083 ELQKKYQQKLEQEENPGNDNVTIMELQTQLAQKTTLISDSKLKEQEFREQIHNLEDRLKK 2142

Query: 498  LQA-THAETVQELEKTRNM 515
             +   +A TV    K  N+
Sbjct: 2143 YEKNVYATTVGTPYKGGNL 2161



 Score = 38.1 bits (87), Expect = 0.052
 Identities = 64/307 (20%), Positives = 136/307 (44%), Gaps = 27/307 (8%)

Query: 306 LMANGDELNMQLKEQRLKCCSLEKQLHSMKFSERRIEELQDRINDLEKERELLKENYDKL 365
           L+ N D LN +   QRL+   +E+ L S +    +  EL      L++E++ L+    + 
Sbjct: 127 LVGNSDSLNKEQLIQRLR--RMERSLSSYR---GKYSELVTAYQMLQREKKKLQGILSQS 181

Query: 366 YDSAFSAAHEEQWKLK-EQQLKVQIAQLETALKSDLTDKTEILDRLKTERDQNEKLVQEN 424
            D +     E + +L+ +QQ K     L+    + L +K + +  L+T+    ++ ++ N
Sbjct: 182 QDKSLRRIAELREELQMDQQAK---KHLQEEFDASLEEKDQYISVLQTQVSLLKQRLR-N 237

Query: 425 RELQLQYLEQKQQLD-ELKKRIKLYNQEND---INADELSEALLLIKAQKEQKNGDLSFL 480
             + +  L+   QL+ + +   K  N E+D   +  D  S   L    Q+ ++  +L   
Sbjct: 238 GPMNVDVLKPLPQLEPQAEVFTKEENPESDGEPVVEDGTSVKTLETLQQRVKRQENLLKR 297

Query: 481 VKVDSEINKD----LERSMRELQATHAETVQELEKTRNMLIMQHKINKDYQM-EVEAVTR 535
            K   + +K+    L      LQ    E +QELEK +++    H   K   + ++     
Sbjct: 298 CKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDL----HMAEKTKLITQLRDAKN 353

Query: 536 KMENLQQDYELKV----EQYVHLLDIRAARIHKLEAQLKDIAYGTKQYKFKPEIMPDDSV 591
            +E L+QD  + +     Q    L+++   I +L +++K +    ++ + + E     + 
Sbjct: 354 LIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEKSERAAF 413

Query: 592 DEFDETI 598
           +E ++ +
Sbjct: 414 EELEKAL 420



 Score = 37.7 bits (86), Expect = 0.068
 Identities = 58/297 (19%), Positives = 124/297 (41%), Gaps = 37/297 (12%)

Query: 342 EELQDRINDLEKERELLKENYDKLYDSAFSAAHEEQWKLKEQQLKVQIAQLETALKSDLT 401
           E+L  R+  +E+     +  Y +L  +A+     E+ KL+          L  +    L 
Sbjct: 137 EQLIQRLRRMERSLSSYRGKYSELV-TAYQMLQREKKKLQ--------GILSQSQDKSLR 187

Query: 402 DKTEILDRLKTERDQNEKLVQENRELQLQYLEQKQQLDELKKRIKLYNQE---NDINADE 458
              E+ + L+ ++ Q +K +QE  +  L+  E+ Q +  L+ ++ L  Q      +N D 
Sbjct: 188 RIAELREELQMDQ-QAKKHLQEEFDASLE--EKDQYISVLQTQVSLLKQRLRNGPMNVDV 244

Query: 459 LS-------EALLLIKAQKEQKNGDLSFLVKVDSEINKDLERSMRELQATHAETVQELEK 511
           L        +A +  K +  + +G+    V  D    K LE              Q +++
Sbjct: 245 LKPLPQLEPQAEVFTKEENPESDGEP---VVEDGTSVKTLETLQ-----------QRVKR 290

Query: 512 TRNMLIMQHKINKDYQMEVEAVTRKMENLQQDYELKVEQYVHLLDIRAARIHKLEAQLKD 571
             N+L    +  + ++ +   +T + E LQ+  + ++++   + D+  A   KL  QL+D
Sbjct: 291 QENLLKRCKETIQSHKEQCTLLTSEKEALQEQLDERLQELEKIKDLHMAEKTKLITQLRD 350

Query: 572 IAYGTKQYKFKPEIMPDDSVDEFDETIHLERGE-NLFEIHINKVTFSSEVLQASGDK 627
                +Q +    ++  ++  +  ET+ ++  E       I ++T   E L+   +K
Sbjct: 351 AKNLIEQLEQDKGMVIAETKRQMHETLEMKEEEIAQLRSRIKQMTTQGEELREQKEK 407


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.132    0.365 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 44,433,610
Number of Sequences: 37866
Number of extensions: 2066997
Number of successful extensions: 15542
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 170
Number of HSP's successfully gapped in prelim test: 1046
Number of HSP's that attempted gapping in prelim test: 8561
Number of HSP's gapped (non-prelim): 4467
length of query: 1235
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1121
effective length of database: 13,930,794
effective search space: 15616420074
effective search space used: 15616420074
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 68 (30.8 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.