Guide to the Human Genome
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Search of human proteins with 189163501

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|189163501 serine peptidase inhibitor, Kazal type 5 isoform a
precursor [Homo sapiens]
         (1094 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|189163501 serine peptidase inhibitor, Kazal type 5 isoform a ...  2279   0.0  
gi|74027261 serine peptidase inhibitor, Kazal type 5 isoform b p...  2206   0.0  
gi|189163504 serine peptidase inhibitor, Kazal type 5 isoform c ...  1901   0.0  
gi|54873613 agrin [Homo sapiens]                                       75   3e-13
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ...    61   7e-09
gi|148746195 trichohyalin [Homo sapiens]                               61   7e-09
gi|148839339 nexilin (F actin binding protein) [Homo sapiens]          57   7e-08
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik...    54   1e-06
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    52   4e-06
gi|45505132 serine protease inhibitor, Kazal type 1 precursor [H...    51   7e-06
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap...    51   7e-06
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li...    51   7e-06
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof...    51   7e-06
gi|68299793 serine protease inhibitor, Kazal type 6 [Homo sapiens]     51   7e-06
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa...    50   9e-06
gi|13540523 nucleosomal binding protein 1 [Homo sapiens]               50   1e-05
gi|29568105 transmembrane protein with EGF-like and two follista...    49   3e-05
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li...    48   4e-05
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]     48   6e-05
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]     48   6e-05
gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]            48   6e-05
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof...    47   8e-05
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                       47   1e-04
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof...    47   1e-04
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof...    47   1e-04
gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [...    47   1e-04
gi|47679099 Kazal type serine protease inhibitor 5-like 2 [Homo ...    47   1e-04
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]    46   2e-04
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]    46   2e-04
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ...    46   2e-04

>gi|189163501 serine peptidase inhibitor, Kazal type 5 isoform a
            precursor [Homo sapiens]
          Length = 1094

 Score = 2279 bits (5907), Expect = 0.0
 Identities = 1094/1094 (100%), Positives = 1094/1094 (100%)

Query: 1    MKIATVSVLLPLALCLIQDAASKNEDQEMCHEFQAFMKNGKLFCPQDKKFFQSLDGIMFI 60
            MKIATVSVLLPLALCLIQDAASKNEDQEMCHEFQAFMKNGKLFCPQDKKFFQSLDGIMFI
Sbjct: 1    MKIATVSVLLPLALCLIQDAASKNEDQEMCHEFQAFMKNGKLFCPQDKKFFQSLDGIMFI 60

Query: 61   NKCATCKMILEKEAKSQKRARHLARAPKATAPTELNCDDFKKGERDGDFICPDYYEAVCG 120
            NKCATCKMILEKEAKSQKRARHLARAPKATAPTELNCDDFKKGERDGDFICPDYYEAVCG
Sbjct: 61   NKCATCKMILEKEAKSQKRARHLARAPKATAPTELNCDDFKKGERDGDFICPDYYEAVCG 120

Query: 121  TDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSNPEQDVCSAFRPFVRDGRLGCTREND 180
            TDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSNPEQDVCSAFRPFVRDGRLGCTREND
Sbjct: 121  TDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSNPEQDVCSAFRPFVRDGRLGCTREND 180

Query: 181  PVLGPDGKTHGNKCAMCAELFLKEAENAKREGETRIRRNAEKDFCKEYEKQVRNGRLFCT 240
            PVLGPDGKTHGNKCAMCAELFLKEAENAKREGETRIRRNAEKDFCKEYEKQVRNGRLFCT
Sbjct: 181  PVLGPDGKTHGNKCAMCAELFLKEAENAKREGETRIRRNAEKDFCKEYEKQVRNGRLFCT 240

Query: 241  RESDPVRGPDGRMHGNKCALCAEIFKQRFSEENSKTDQNLGKAEEKTKVKREIVKLCSQY 300
            RESDPVRGPDGRMHGNKCALCAEIFKQRFSEENSKTDQNLGKAEEKTKVKREIVKLCSQY
Sbjct: 241  RESDPVRGPDGRMHGNKCALCAEIFKQRFSEENSKTDQNLGKAEEKTKVKREIVKLCSQY 300

Query: 301  QNQAKNGILFCTRENDPIRGPDGKMHGNLCSMCQAYFQAENEEKKKAEARARNKRESGKA 360
            QNQAKNGILFCTRENDPIRGPDGKMHGNLCSMCQAYFQAENEEKKKAEARARNKRESGKA
Sbjct: 301  QNQAKNGILFCTRENDPIRGPDGKMHGNLCSMCQAYFQAENEEKKKAEARARNKRESGKA 360

Query: 361  TSYAELCSEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGK 420
            TSYAELCSEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGK
Sbjct: 361  TSYAELCSEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGK 420

Query: 421  SRNKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQE 480
            SRNKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQE
Sbjct: 421  SRNKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQE 480

Query: 481  ERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFKLEE 540
            ERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFKLEE
Sbjct: 481  ERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFKLEE 540

Query: 541  EEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTC 600
            EEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTC
Sbjct: 541  EEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTC 600

Query: 601  SMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKT 660
            SMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKT
Sbjct: 601  SMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKT 660

Query: 661  HGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLS 720
            HGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLS
Sbjct: 661  HGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLS 720

Query: 721  CTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQ 780
            CTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQ
Sbjct: 721  CTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQ 780

Query: 781  MKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGE 840
            MKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGE
Sbjct: 781  MKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGE 840

Query: 841  RSNDKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKD 900
            RSNDKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKD
Sbjct: 841  RSNDKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKD 900

Query: 901  EEKSSSKPSNNAKDQCRQVQNEAEDAKFRQPGRSLASVARMSTDECSEFRNYIRNNELIC 960
            EEKSSSKPSNNAKDQCRQVQNEAEDAKFRQPGRSLASVARMSTDECSEFRNYIRNNELIC
Sbjct: 901  EEKSSSKPSNNAKDQCRQVQNEAEDAKFRQPGRSLASVARMSTDECSEFRNYIRNNELIC 960

Query: 961  PRENDPVHGADGKFYTNKCYMCRAVFLTEALERAKLQEKPSHVRASQEEDSPDSFSSLDS 1020
            PRENDPVHGADGKFYTNKCYMCRAVFLTEALERAKLQEKPSHVRASQEEDSPDSFSSLDS
Sbjct: 961  PRENDPVHGADGKFYTNKCYMCRAVFLTEALERAKLQEKPSHVRASQEEDSPDSFSSLDS 1020

Query: 1021 EMCKDYRVLPRIGYLCPKDLKPVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKCEESS 1080
            EMCKDYRVLPRIGYLCPKDLKPVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKCEESS
Sbjct: 1021 EMCKDYRVLPRIGYLCPKDLKPVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKCEESS 1080

Query: 1081 TPGTTAASMPPSDE 1094
            TPGTTAASMPPSDE
Sbjct: 1081 TPGTTAASMPPSDE 1094


>gi|74027261 serine peptidase inhibitor, Kazal type 5 isoform b
            precursor [Homo sapiens]
          Length = 1064

 Score = 2206 bits (5715), Expect = 0.0
 Identities = 1064/1094 (97%), Positives = 1064/1094 (97%), Gaps = 30/1094 (2%)

Query: 1    MKIATVSVLLPLALCLIQDAASKNEDQEMCHEFQAFMKNGKLFCPQDKKFFQSLDGIMFI 60
            MKIATVSVLLPLALCLIQDAASKNEDQEMCHEFQAFMKNGKLFCPQDKKFFQSLDGIMFI
Sbjct: 1    MKIATVSVLLPLALCLIQDAASKNEDQEMCHEFQAFMKNGKLFCPQDKKFFQSLDGIMFI 60

Query: 61   NKCATCKMILEKEAKSQKRARHLARAPKATAPTELNCDDFKKGERDGDFICPDYYEAVCG 120
            NKCATCKMILEKEAKSQKRARHLARAPKATAPTELNCDDFKKGERDGDFICPDYYEAVCG
Sbjct: 61   NKCATCKMILEKEAKSQKRARHLARAPKATAPTELNCDDFKKGERDGDFICPDYYEAVCG 120

Query: 121  TDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSNPEQDVCSAFRPFVRDGRLGCTREND 180
            TDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSNPEQDVCSAFRPFVRDGRLGCTREND
Sbjct: 121  TDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSNPEQDVCSAFRPFVRDGRLGCTREND 180

Query: 181  PVLGPDGKTHGNKCAMCAELFLKEAENAKREGETRIRRNAEKDFCKEYEKQVRNGRLFCT 240
            PVLGPDGKTHGNKCAMCAELFLKEAENAKREGETRIRRNAEKDFCKEYEKQVRNGRLFCT
Sbjct: 181  PVLGPDGKTHGNKCAMCAELFLKEAENAKREGETRIRRNAEKDFCKEYEKQVRNGRLFCT 240

Query: 241  RESDPVRGPDGRMHGNKCALCAEIFKQRFSEENSKTDQNLGKAEEKTKVKREIVKLCSQY 300
            RESDPVRGPDGRMHGNKCALCAEIFKQRFSEENSKTDQNLGKAEEKTKVKREIVKLCSQY
Sbjct: 241  RESDPVRGPDGRMHGNKCALCAEIFKQRFSEENSKTDQNLGKAEEKTKVKREIVKLCSQY 300

Query: 301  QNQAKNGILFCTRENDPIRGPDGKMHGNLCSMCQAYFQAENEEKKKAEARARNKRESGKA 360
            QNQAKNGILFCTRENDPIRGPDGKMHGNLCSMCQAYFQAENEEKKKAEARARNKRESGKA
Sbjct: 301  QNQAKNGILFCTRENDPIRGPDGKMHGNLCSMCQAYFQAENEEKKKAEARARNKRESGKA 360

Query: 361  TSYAELCSEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGK 420
            TSYAELCSEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGK
Sbjct: 361  TSYAELCSEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGK 420

Query: 421  SRNKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQE 480
            SRNKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQE
Sbjct: 421  SRNKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQE 480

Query: 481  ERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFKLEE 540
            ERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFKLEE
Sbjct: 481  ERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFKLEE 540

Query: 541  EEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTC 600
            EEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTC
Sbjct: 541  EEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTC 600

Query: 601  SMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKT 660
            SMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKT
Sbjct: 601  SMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKT 660

Query: 661  HGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLS 720
            HGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLS
Sbjct: 661  HGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLS 720

Query: 721  CTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQ 780
            CTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQ
Sbjct: 721  CTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQ 780

Query: 781  MKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGE 840
            MKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGE
Sbjct: 781  MKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGE 840

Query: 841  RSNDKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKD 900
            RSNDKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKD
Sbjct: 841  RSNDKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKD 900

Query: 901  EEKSSSKPSNNAKDQCRQVQNEAEDAKFRQPGRSLASVARMSTDECSEFRNYIRNNELIC 960
            EEKSSSKPSNNAKD                              ECSEFRNYIRNNELIC
Sbjct: 901  EEKSSSKPSNNAKD------------------------------ECSEFRNYIRNNELIC 930

Query: 961  PRENDPVHGADGKFYTNKCYMCRAVFLTEALERAKLQEKPSHVRASQEEDSPDSFSSLDS 1020
            PRENDPVHGADGKFYTNKCYMCRAVFLTEALERAKLQEKPSHVRASQEEDSPDSFSSLDS
Sbjct: 931  PRENDPVHGADGKFYTNKCYMCRAVFLTEALERAKLQEKPSHVRASQEEDSPDSFSSLDS 990

Query: 1021 EMCKDYRVLPRIGYLCPKDLKPVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKCEESS 1080
            EMCKDYRVLPRIGYLCPKDLKPVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKCEESS
Sbjct: 991  EMCKDYRVLPRIGYLCPKDLKPVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKCEESS 1050

Query: 1081 TPGTTAASMPPSDE 1094
            TPGTTAASMPPSDE
Sbjct: 1051 TPGTTAASMPPSDE 1064


>gi|189163504 serine peptidase inhibitor, Kazal type 5 isoform c
           precursor [Homo sapiens]
          Length = 916

 Score = 1901 bits (4924), Expect = 0.0
 Identities = 913/913 (100%), Positives = 913/913 (100%)

Query: 1   MKIATVSVLLPLALCLIQDAASKNEDQEMCHEFQAFMKNGKLFCPQDKKFFQSLDGIMFI 60
           MKIATVSVLLPLALCLIQDAASKNEDQEMCHEFQAFMKNGKLFCPQDKKFFQSLDGIMFI
Sbjct: 1   MKIATVSVLLPLALCLIQDAASKNEDQEMCHEFQAFMKNGKLFCPQDKKFFQSLDGIMFI 60

Query: 61  NKCATCKMILEKEAKSQKRARHLARAPKATAPTELNCDDFKKGERDGDFICPDYYEAVCG 120
           NKCATCKMILEKEAKSQKRARHLARAPKATAPTELNCDDFKKGERDGDFICPDYYEAVCG
Sbjct: 61  NKCATCKMILEKEAKSQKRARHLARAPKATAPTELNCDDFKKGERDGDFICPDYYEAVCG 120

Query: 121 TDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSNPEQDVCSAFRPFVRDGRLGCTREND 180
           TDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSNPEQDVCSAFRPFVRDGRLGCTREND
Sbjct: 121 TDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSNPEQDVCSAFRPFVRDGRLGCTREND 180

Query: 181 PVLGPDGKTHGNKCAMCAELFLKEAENAKREGETRIRRNAEKDFCKEYEKQVRNGRLFCT 240
           PVLGPDGKTHGNKCAMCAELFLKEAENAKREGETRIRRNAEKDFCKEYEKQVRNGRLFCT
Sbjct: 181 PVLGPDGKTHGNKCAMCAELFLKEAENAKREGETRIRRNAEKDFCKEYEKQVRNGRLFCT 240

Query: 241 RESDPVRGPDGRMHGNKCALCAEIFKQRFSEENSKTDQNLGKAEEKTKVKREIVKLCSQY 300
           RESDPVRGPDGRMHGNKCALCAEIFKQRFSEENSKTDQNLGKAEEKTKVKREIVKLCSQY
Sbjct: 241 RESDPVRGPDGRMHGNKCALCAEIFKQRFSEENSKTDQNLGKAEEKTKVKREIVKLCSQY 300

Query: 301 QNQAKNGILFCTRENDPIRGPDGKMHGNLCSMCQAYFQAENEEKKKAEARARNKRESGKA 360
           QNQAKNGILFCTRENDPIRGPDGKMHGNLCSMCQAYFQAENEEKKKAEARARNKRESGKA
Sbjct: 301 QNQAKNGILFCTRENDPIRGPDGKMHGNLCSMCQAYFQAENEEKKKAEARARNKRESGKA 360

Query: 361 TSYAELCSEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGK 420
           TSYAELCSEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGK
Sbjct: 361 TSYAELCSEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGK 420

Query: 421 SRNKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQE 480
           SRNKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQE
Sbjct: 421 SRNKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQE 480

Query: 481 ERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFKLEE 540
           ERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFKLEE
Sbjct: 481 ERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFKLEE 540

Query: 541 EEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTC 600
           EEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTC
Sbjct: 541 EEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTC 600

Query: 601 SMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKT 660
           SMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKT
Sbjct: 601 SMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKT 660

Query: 661 HGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLS 720
           HGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLS
Sbjct: 661 HGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLS 720

Query: 721 CTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQ 780
           CTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQ
Sbjct: 721 CTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQ 780

Query: 781 MKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGE 840
           MKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGE
Sbjct: 781 MKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGE 840

Query: 841 RSNDKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKD 900
           RSNDKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKD
Sbjct: 841 RSNDKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKD 900

Query: 901 EEKSSSKPSNNAK 913
           EEKSSSKPSNNAK
Sbjct: 901 EEKSSSKPSNNAK 913



 Score =  780 bits (2013), Expect = 0.0
 Identities = 417/956 (43%), Positives = 573/956 (59%), Gaps = 81/956 (8%)

Query: 150  ECKSSNPEQDVCSAFRPFVRDGRLGCTRENDPVLGPDGKTHGNKCAMCAELFLKEAENAK 209
            +  S N +Q++C  F+ F+++G+L C ++       DG    NKCA C  +  KEA++ K
Sbjct: 19   DAASKNEDQEMCHEFQAFMKNGKLFCPQDKKFFQSLDGIMFINKCATCKMILEKEAKSQK 78

Query: 210  REGETRIRRNAEKDF---CKEYEKQVRNGRLFCTRESDPVRGPDGRMHGNKCALCAEIFK 266
            R         A       C +++K  R+G   C    + V G DG+ + N+CALCAE   
Sbjct: 79   RARHLARAPKATAPTELNCDDFKKGERDGDFICPDYYEAVCGTDGKTYDNRCALCAE--- 135

Query: 267  QRFSEENSKTDQNLG-KAEEKTKVKREIVKLCSQYQNQAKNGILFCTRENDPIRGPDGKM 325
                  N+KT   +G K+E + K       +CS ++   ++G L CTRENDP+ GPDGK 
Sbjct: 136  ------NAKTGSQIGVKSEGECKSSNPEQDVCSAFRPFVRDGRLGCTRENDPVLGPDGKT 189

Query: 326  HGNLCSMCQAYFQAENEEKKKAEARARNKRESGKATSYAELCSEYRKLVRNGKLACTREN 385
            HGN C+MC   F  E E  K+ E   R +R + K     + C EY K VRNG+L CTRE+
Sbjct: 190  HGNKCAMCAELFLKEAENAKR-EGETRIRRNAEK-----DFCKEYEKQVRNGRLFCTRES 243

Query: 386  DPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNKRQSKSTASFE--ELCSEYRKS 443
            DP++GPDG++HGN C++C   F+    E+  K  ++  K + K+    E  +LCS+Y+  
Sbjct: 244  DPVRGPDGRMHGNKCALCAEIFKQRFSEENSKTDQNLGKAEEKTKVKREIVKLCSQYQNQ 303

Query: 444  RKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQEER------ARAKAKREAAK---- 493
             KNG LFCTRENDPI+GPDGKMHGN CSMC+A+FQ E        ARA+ KRE+ K    
Sbjct: 304  AKNGILFCTRENDPIRGPDGKMHGNLCSMCQAYFQAENEEKKKAEARARNKRESGKATSY 363

Query: 494  -EICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFKLEEEEKKNDKEEKGK 552
             E+CSE+R  VRNG L CTRE++P++GPDGK+HGN C+MC   F+ EEEEKK  KE K +
Sbjct: 364  AELCSEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKK-KEGKSR 422

Query: 553  VEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTCSMCEAFFQQEAK 612
             + +     + +ELCSEYR   +NGRL CTRENDPI+G DGK+HGNTCSMCEAFFQQE  
Sbjct: 423  NKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQE-- 480

Query: 613  EKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCAMCKAVF 672
              ERA  RAK KREA KE C EFR  ++NG L CTRE++PVRGPDGK HGNKCAMC +VF
Sbjct: 481  --ERA--RAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVF 536

Query: 673  QKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVRDAD 732
            + E EE+K  +EE  +  A            Q+ C+EYR  ++NGRL CTRE+DP+   D
Sbjct: 537  KLEEEEKKNDKEEKGKVEAEKVKREA----VQELCSEYRHYVRNGRLPCTRENDPIEGLD 592

Query: 733  GKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKLICTRES 792
            GK + N C+MC+A  ++EA+ K E +  R+     E+ K+TCDEFR  ++NGKL CTRE+
Sbjct: 593  GKIHGNTCSMCEAFFQQEAKEK-ERAEPRAK-VKREAEKETCDEFRRLLQNGKLFCTREN 650

Query: 793  DPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGERSNDKEDLCREF 852
            DPVRGPDGKTHGNKC MCK   ++E  E+K+KE+ED+ N     ++G    + +D C E+
Sbjct: 651  DPVRGPDGKTHGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEY 710

Query: 853  RSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKDEEKSSSKPSNNA 912
            R   +NG+L CTRE++PVR   GK + N+C MC++  +REA  + +    +S+   S + 
Sbjct: 711  REQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESG 770

Query: 913  KDQCRQVQNEAEDAKFRQPGRSLASVARMSTDECSEFRNYIRNNELICPRENDPVHGADG 972
            K                              D C EFR+ ++N +LIC RE+DPV G DG
Sbjct: 771  K------------------------------DTCDEFRSQMKNGKLICTRESDPVRGPDG 800

Query: 973  KFYTNKCYMCRAVFLTEALERAKLQEKPSHVRASQEEDSPDSFSSLDSE-MCKDYRVLPR 1031
            K + NKC MC+     EA E+ K +++    R++  E S     S D E +C+++R + R
Sbjct: 801  KTHGNKCTMCKEKLEREAAEKKKKEDED---RSNTGERSNTGERSNDKEDLCREFRSMQR 857

Query: 1032 IGYL-CPKDLKPVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKCEESSTPGTTA 1086
             G L C ++  PV G  G+ + N C +C     R+ N   +   + + SS P   A
Sbjct: 858  NGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANER-KKKDEEKSSSKPSNNA 912



 Score =  262 bits (670), Expect = 1e-69
 Identities = 156/466 (33%), Positives = 232/466 (49%), Gaps = 59/466 (12%)

Query: 625  REAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCAMCKAVFQKENEERKRKEE 684
            +  ++E C EF+  ++NGKLFC ++    +  DG    NKCA CK + +KE + +KR   
Sbjct: 23   KNEDQEMCHEFQAFMKNGKLFCPQDKKFFQSLDGIMFINKCATCKMILEKEAKSQKRARH 82

Query: 685  EDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMC- 743
              +   A           T+  C ++++  ++G   C    + V   DGK+Y+N+C +C 
Sbjct: 83   LARAPKAT--------APTELNCDDFKKGERDGDFICPDYYEAVCGTDGKTYDNRCALCA 134

Query: 744  -KAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKLICTRESDPVRGPDGKT 802
              AK   +   K+E     SN       +D C  FR  +++G+L CTRE+DPV GPDGKT
Sbjct: 135  ENAKTGSQIGVKSEGECKSSNPE-----QDVCSAFRPFVRDGRLGCTRENDPVLGPDGKT 189

Query: 803  HGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGERSNDKEDLCREFRSMQRNGKLI 862
            HGNKC MC E   +EA E  K+E E R           R N ++D C+E+    RNG+L 
Sbjct: 190  HGNKCAMCAELFLKEA-ENAKREGETRI----------RRNAEKDFCKEYEKQVRNGRLF 238

Query: 863  CTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKDEEKSSSKPSNNAKDQCRQVQNE 922
            CTRE++PVRGP G+MH NKCA+C  IF +  +E   K ++                   +
Sbjct: 239  CTRESDPVRGPDGRMHGNKCALCAEIFKQRFSEENSKTDQNLG----------------K 282

Query: 923  AEDAKFRQPGRSLASVARMSTDECSEFRNYIRNNELICPRENDPVHGADGKFYTNKCYMC 982
            AE+            V R     CS+++N  +N  L C RENDP+ G DGK + N C MC
Sbjct: 283  AEEK---------TKVKREIVKLCSQYQNQAKNGILFCTRENDPIRGPDGKMHGNLCSMC 333

Query: 983  RAVFLTEALERAKLQEKPSHVRASQEEDSPDSFSSLDSEMCKDYRVLPRIGYL-CPKDLK 1041
            +A F  E  E+ K + +  + R S +  S        +E+C +YR L R G L C ++  
Sbjct: 334  QAYFQAENEEKKKAEARARNKRESGKATSY-------AELCSEYRKLVRNGKLACTREND 386

Query: 1042 PVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKCEESSTPGTTAA 1087
            P+ G DG+ + N C +C      +     +  GK        +TA+
Sbjct: 387  PIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNKRQSKSTAS 432



 Score = 85.1 bits (209), Expect = 3e-16
 Identities = 43/147 (29%), Positives = 75/147 (51%), Gaps = 11/147 (7%)

Query: 946  CSEFRNYIRNNELICPRENDPVHGADGKFYTNKCYMCRAVFLTEALERAKLQEKPSHVRA 1005
            C EF+ +++N +L CP++       DG  + NKC  C+ +   EA    K Q++  H+  
Sbjct: 30   CHEFQAFMKNGKLFCPQDKKFFQSLDGIMFINKCATCKMILEKEA----KSQKRARHLAR 85

Query: 1006 SQEEDSPDSFSSLDSEMCKDYRVLPRIG-YLCPKDLKPVCGDDGQTYNNPCMLCHENLIR 1064
            + +  +P   +      C D++   R G ++CP   + VCG DG+TY+N C LC EN   
Sbjct: 86   APKATAPTELN------CDDFKKGERDGDFICPDYYEAVCGTDGKTYDNRCALCAENAKT 139

Query: 1065 QTNTHIRSTGKCEESSTPGTTAASMPP 1091
             +   ++S G+C+ S+      ++  P
Sbjct: 140  GSQIGVKSEGECKSSNPEQDVCSAFRP 166


>gi|54873613 agrin [Homo sapiens]
          Length = 2045

 Score = 75.5 bits (184), Expect = 3e-13
 Identities = 163/801 (20%), Positives = 259/801 (32%), Gaps = 138/801 (17%)

Query: 111 CPDYYEAVCGTDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSNPEQDVCSAFRPFVRD 170
           CP     VCG+D  TY N C L         +I + S G C S +P  +V  +F      
Sbjct: 202 CPSVVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCAR 261

Query: 171 GRLGCTRE-----------NDPVLGPDGKTHGNKCAMCAELFLKEAENAKR-EGETRIRR 218
              G T                V G DG  +  +C +      ++    K+ +G     +
Sbjct: 262 SADGLTASCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPCQ 321

Query: 219 NAEKD---FCKEYEKQVRNGRLF----CTRESDPVRGPDGRMHGNKCALCAEIFKQRFSE 271
            A  D    C+   +  R   L     C     PV G DG  + N C +      +    
Sbjct: 322 GALPDPSRSCRVNPRTRRPEMLLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLL 381

Query: 272 ENSKTDQNLGKAEEKTKVKREIVKLCSQYQNQAKNGILFCTRENDPIRGPDGKMHGNLCS 331
           +  ++ Q  G+ +     +   V L  + + +     + C     P+   DG+ + + C 
Sbjct: 382 QKVRSGQCQGRDQCPEPCRFNAVCLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCW 441

Query: 332 MCQAYFQAENEEKKKAEARARNKRES--GKATSYAELCSEYRKLVRNGKL------ACTR 383
             QA  + +     K +           G   ++   C+     V+NG+       AC+ 
Sbjct: 442 RQQAECRQQRAIPSKHQGPCDQAPSPCLGVQCAFGATCA-----VKNGQAACECLQACSS 496

Query: 384 ENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNKRQSKSTASFEELCSEYRKS 443
             DP+ G DG  +G+ C +         E +  ++G      Q +    F  LC      
Sbjct: 497 LYDPVCGSDGVTYGSACELEATACTLGREIQVARKGPCDRCGQCR----FGALC-----E 547

Query: 444 RKNGRLFCTRE----NDPIQGPDGKMHGNTCSM--CEAFFQQEERARAKAKREAAKEICS 497
            + GR  C  E      P+ G DG  + + C +       Q      +    E   +   
Sbjct: 548 AETGRCVCPSECVALAQPVCGSDGHTYPSECMLHVHACTHQISLHVASAGPCETCGDAVC 607

Query: 498 EFRDQVRNGTLICTR-EH---NPVRGPDGKMHGNKC----AMCASVFKLEE------EEK 543
            F      G  +C R EH    PV G DG  +G+ C    A C    ++EE      E+ 
Sbjct: 608 AFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPCEQA 667

Query: 544 KNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPC-----TRENDPIEGLDGKIHGN 598
           +      G  E    ++E  ++    +     +G   C     +    P+ G DG  +  
Sbjct: 668 ECGSGGSGSGEDGDCEQELCRQRGGIWDEDSEDGPCVCDFSCQSVPGSPVCGSDGVTYST 727

Query: 599 TCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDG 658
            C                         E +K  C+  R L    +  C         P  
Sbjct: 728 EC-------------------------ELKKARCESQRGLYVAAQGACRGPTFAPLPPVA 762

Query: 659 KTHGNKCAMCKAVFQKENEERKRKEE----EDQRNAAGHGSSGGG--------------G 700
             H   CA       ++N    R               HGS GG               G
Sbjct: 763 PLH---CAQTPYGCCQDNITAARGVGLAGCPSACQCNPHGSYGGTCDPATGQCSCRPGVG 819

Query: 701 GNTQDECA----EYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNE 756
           G   D C      +R  + +GR  CT  S   + A          +C  K      +  +
Sbjct: 820 GLRCDRCEPGFWNFRGIVTDGRSGCTPCSCDPQGAVRDDCEQMTGLCSCKPGVAGPKCGQ 879

Query: 757 YSRSRSNG-TGSE---SGKDTCDEFRSQM------KNGKLICT--------RESDPVRGP 798
               R+ G  G E   S   TC E R +       ++G   C           +  V G 
Sbjct: 880 CPDGRALGPAGCEADASAPATCAEMRCEFGARCVEESGSAHCVCPMLTCPEANATKVCGS 939

Query: 799 DGKTHGNKCTM----CKEKLE 815
           DG T+GN+C +    C++ L+
Sbjct: 940 DGVTYGNECQLKTIACRQGLQ 960



 Score = 56.2 bits (134), Expect = 2e-07
 Identities = 111/568 (19%), Positives = 194/568 (34%), Gaps = 103/568 (18%)

Query: 317 PIRGPDGKMHGNLCSMCQAYFQAENEEKKKAEARARNKRESGKAT-SYAELCSEYRK-LV 374
           P+ G D   + N C + +A    +   +  +     ++      T S+   C+     L 
Sbjct: 208 PVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCARSADGLT 267

Query: 375 RNGKLACTRENDP---IQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNKRQSKSTA 431
            +     T    P   + G DG  +   C +       +E   KK +G     + +    
Sbjct: 268 ASCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPCQGALPDP 327

Query: 432 SFEELCSEYRKSRKNGRLF----CTRENDPIQGPDGKMHGNTCSM-----CEAFFQQEER 482
           S    C    ++R+   L     C     P+ G DG  + N C M           Q+ R
Sbjct: 328 S--RSCRVNPRTRRPEMLLRPESCPARQAPVCGDDGVTYENDCVMGRSGAARGLLLQKVR 385

Query: 483 ARAKAKREAAKEICS--------EFRDQVRNGTLICTREHNPVRGPDGKMHGNKC----A 530
           +     R+   E C           R +     + C   + PV   DG+ + + C    A
Sbjct: 386 SGQCQGRDQCPEPCRFNAVCLSRRGRPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQA 445

Query: 531 MCASVFKLEEEEKKNDKEEKGKVEAEKVKREAVQ----ELCSEYRHYVRNGRLPC----- 581
            C        +++    + +G  +        VQ      C+     V+NG+  C     
Sbjct: 446 EC-------RQQRAIPSKHQGPCDQAPSPCLGVQCAFGATCA-----VKNGQAACECLQA 493

Query: 582 -TRENDPIEGLDGKIHGNTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRR--- 637
            +   DP+ G DG  +G+ C + EA      +E        +V R+   + C + R    
Sbjct: 494 CSSLYDPVCGSDGVTYGSACEL-EATACTLGRE-------IQVARKGPCDRCGQCRFGAL 545

Query: 638 -LLQNGKLFCTRE----NDPVRGPDGKTHGNKCAMCKAVFQKENEERKRKEEEDQRNAAG 692
              + G+  C  E      PV G DG T+ ++C +                       + 
Sbjct: 546 CEAETGRCVCPSECVALAQPVCGSDGHTYPSECML--------------HVHACTHQISL 591

Query: 693 HGSSGGGGGNTQDECAEYREQMKNGRLSCTR----ESDPVRDADGKSYNNQCTM----CK 744
           H +S G      D    +      G+  C R       PV  +DG +Y + C +    C 
Sbjct: 592 HVASAGPCETCGDAVCAFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAACL 651

Query: 745 AKLEREAERKNEYSRSRSNGTGSESGKD-TCDE---------FRSQMKNGKLIC-----T 789
            + + E  R     ++     GS SG+D  C++         +    ++G  +C     +
Sbjct: 652 QQTQIEEARAGPCEQAECGSGGSGSGEDGDCEQELCRQRGGIWDEDSEDGPCVCDFSCQS 711

Query: 790 RESDPVRGPDGKTHGNKCTMCKEKLERE 817
               PV G DG T+  +C + K + E +
Sbjct: 712 VPGSPVCGSDGVTYSTECELKKARCESQ 739



 Score = 53.9 bits (128), Expect = 8e-07
 Identities = 137/667 (20%), Positives = 217/667 (32%), Gaps = 146/667 (21%)

Query: 457  PIQGPDGKMHGNTCSMCEAFFQQEERARAKAKREAAKEICSEFRDQVRNGTLICTREHNP 516
            P+ G D   + N C +  A   Q+ R R  ++           RD   N T  C+     
Sbjct: 208  PVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCGS------RDPCSNVT--CSFGSTC 259

Query: 517  VRGPDGKMHGNKC-AMCASVFKLEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVR 575
             R  DG      C A C                 +G  E      +      ++Y    +
Sbjct: 260  ARSADGLTASCLCPATC-----------------RGAPEGTVCGSDG-----ADYPGECQ 297

Query: 576  NGRLPCTRENDPIEGLDGKIHGNTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEF 635
              R  C R+ +  +  DG      C  C+      ++   R  PR +      +      
Sbjct: 298  LLRRACARQENVFKKFDGP-----CDPCQGALPDPSRSC-RVNPRTRRPEMLLRPESCPA 351

Query: 636  RRLLQNGKLFCTRENDPVRGPDGKTHGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHGS 695
            R+    G    T END V G  G   G    + + V   + + R +  E  + NA     
Sbjct: 352  RQAPVCGDDGVTYENDCVMGRSGAARG---LLLQKVRSGQCQGRDQCPEPCRFNAVCLSR 408

Query: 696  SGGGGGNTQDECAEYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAERKN 755
             G             R +    R++C     PV   DG++Y++ C   +A+  ++    +
Sbjct: 409  RG-------------RPRCSCDRVTCDGAYRPVCAQDGRTYDSDCWRQQAECRQQRAIPS 455

Query: 756  EYSRSRSNGTGSESGKDTCDEFRSQMKNGKLIC------TRESDPVRGPDGKTHGNKCTM 809
            ++            G          +KNG+  C      +   DPV G DG T+G+ C  
Sbjct: 456  KHQGPCDQAPSPCLGVQCAFGATCAVKNGQAACECLQACSSLYDPVCGSDGVTYGSAC-- 513

Query: 810  CKEKLEREAAEKKKKEDEDRSNTGERSNTGERSNDKEDLCREFRSM--QRNGKLICTRE- 866
               +LE  A    ++    R    +R             CR F ++     G+ +C  E 
Sbjct: 514  ---ELEATACTLGREIQVARKGPCDRCGQ----------CR-FGALCEAETGRCVCPSEC 559

Query: 867  ---NNPVRGPYGKMHINKCAMCQSIFDREANERKKKDEEKSSSKPSNNAKDQCRQVQNEA 923
                 PV G  G  + ++C +       + +         +S+ P     D         
Sbjct: 560  VALAQPVCGSDGHTYPSECMLHVHACTHQISLHV------ASAGPCETCGDAV------- 606

Query: 924  EDAKFRQPGRSLASVARMSTDECSEFRNYIRNNELICPR----ENDPVHGADGKFYTNKC 979
                        A  A  S  +C            +CPR       PV G+DG  Y + C
Sbjct: 607  -----------CAFGAVCSAGQC------------VCPRCEHPPPGPVCGSDGVTYGSAC 643

Query: 980  YMCRAVFLTEALERAKLQEKPSHVRASQEEDSPDSFSSLDSEMCKDYRVLPRIGYL---- 1035
             +  A      L++ +++E  +      E  S  S S  D + C+      R G      
Sbjct: 644  ELREAA----CLQQTQIEEARAGPCEQAECGSGGSGSGEDGD-CEQELCRQRGGIWDEDS 698

Query: 1036 ----CPKDLK-------PVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKCEESSTPGT 1084
                C  D         PVCG DG TY+  C L       Q   ++ + G C      G 
Sbjct: 699  EDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGACR-----GP 753

Query: 1085 TAASMPP 1091
            T A +PP
Sbjct: 754  TFAPLPP 760



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 114/542 (21%), Positives = 182/542 (33%), Gaps = 117/542 (21%)

Query: 580  PCTRENDPIEGLDGKIHGNTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLL 639
            PC     P+ G D   + N C +  A   Q+ + +  +      +      TC       
Sbjct: 201  PCPSVVAPVCGSDASTYSNECELQRAQCSQQRRIRLLSRGPCGSRDPCSNVTCSFGSTCA 260

Query: 640  QNG-----KLFC--TRENDP---VRGPDGKTHGNKCAMCK-AVFQKENEERKRKEEEDQR 688
            ++         C  T    P   V G DG  +  +C + + A  ++EN  +K     D  
Sbjct: 261  RSADGLTASCLCPATCRGAPEGTVCGSDGADYPGECQLLRRACARQENVFKKFDGPCDPC 320

Query: 689  NAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKLE 748
              A    S     N +      R +M     SC     PV   DG +Y N C M ++   
Sbjct: 321  QGALPDPSRSCRVNPRTR----RPEMLLRPESCPARQAPVCGDDGVTYENDCVMGRSG-- 374

Query: 749  REAERKNEYSRSRSNGTGSESGKDTCDE------------FRSQMKNGKLICTRESDPVR 796
              A R     + RS   G   G+D C E             R +    ++ C     PV 
Sbjct: 375  --AARGLLLQKVRS---GQCQGRDQCPEPCRFNAVCLSRRGRPRCSCDRVTCDGAYRPVC 429

Query: 797  GPDGKTHGNKCTMCKEKLEREAAEKKKKEDE-DRSNT---GERSNTGERSNDK--EDLCR 850
              DG+T+ + C   + +  ++ A   K +   D++ +   G +   G     K  +  C 
Sbjct: 430  AQDGRTYDSDCWRQQAECRQQRAIPSKHQGPCDQAPSPCLGVQCAFGATCAVKNGQAACE 489

Query: 851  EFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKDEEKSSSKPSN 910
              ++        C+   +PV G  G  + + C +       EA       E + + K   
Sbjct: 490  CLQA--------CSSLYDPVCGSDGVTYGSACEL-------EATACTLGREIQVARKGPC 534

Query: 911  NAKDQCRQVQNEAEDAKFRQPGRSLASVARMSTDECSEFRNYIRNNELICPRE----NDP 966
            +   QCR                   ++    T  C            +CP E      P
Sbjct: 535  DRCGQCR-----------------FGALCEAETGRC------------VCPSECVALAQP 565

Query: 967  VHGADGKFYTNKCYMCRAVFLTEALERAKLQEKPSHVRASQEEDSPDSFSSLDSEMCKD- 1025
            V G+DG  Y ++C +                    HV A   + S    S+   E C D 
Sbjct: 566  VCGSDGHTYPSECML--------------------HVHACTHQISLHVASAGPCETCGDA 605

Query: 1026 ---YRVLPRIGY-LCPK----DLKPVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKCE 1077
               +  +   G  +CP+       PVCG DG TY + C L     ++QT       G CE
Sbjct: 606  VCAFGAVCSAGQCVCPRCEHPPPGPVCGSDGVTYGSACELREAACLQQTQIEEARAGPCE 665

Query: 1078 ES 1079
            ++
Sbjct: 666  QA 667



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 77/374 (20%), Positives = 118/374 (31%), Gaps = 82/374 (21%)

Query: 717  GRLSCTRESDP-------VRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSES 769
            GR SC  +  P       V  +D  +Y+N+C + +A+  ++        R R    G   
Sbjct: 191  GRASCVCKKSPCPSVVAPVCGSDASTYSNECELQRAQCSQQR-------RIRLLSRGPCG 243

Query: 770  GKDTCDEFRSQMKNGKLICTRESD------------------PVRGPDGKTHGNKCTMCK 811
             +D C        +    C R +D                   V G DG  +  +C + +
Sbjct: 244  SRDPCSNVTCSFGS---TCARSADGLTASCLCPATCRGAPEGTVCGSDGADYPGECQLLR 300

Query: 812  EKLEREAAEKKKKEDEDRSNTGERSNTGERSNDKEDLCREFRSMQRNGKLI----CTREN 867
                R+    KK +       G          D    CR     +R   L+    C    
Sbjct: 301  RACARQENVFKKFDGPCDPCQGALP-------DPSRSCRVNPRTRRPEMLLRPESCPARQ 353

Query: 868  NPVRGPYGKMHINKCAMCQSIFDREANERKKKDEEKSSSKPSNNAKDQCRQVQNEAEDAK 927
             PV G  G  + N C M +S   R    +K +  +          +DQC       E  +
Sbjct: 354  APVCGDDGVTYENDCVMGRSGAARGLLLQKVRSGQCQG-------RDQC------PEPCR 400

Query: 928  FRQPGRSLASVARMSTDECSEFRNYIRNNELICPRENDPVHGADGKFYTNKCYM----CR 983
            F     +   ++R     CS  R       + C     PV   DG+ Y + C+     CR
Sbjct: 401  F-----NAVCLSRRGRPRCSCDR-------VTCDGAYRPVCAQDGRTYDSDCWRQQAECR 448

Query: 984  AVFLTEALERAKLQEKPSHVRASQEEDSPDSFSSLDSEMCKDYRVLPRIGYLCPKDLKPV 1043
                  +  +    + PS     Q               C+  +        C     PV
Sbjct: 449  QQRAIPSKHQGPCDQAPSPCLGVQCAFGATCAVKNGQAACECLQA-------CSSLYDPV 501

Query: 1044 CGDDGQTYNNPCML 1057
            CG DG TY + C L
Sbjct: 502  CGSDGVTYGSACEL 515



 Score = 38.1 bits (87), Expect = 0.046
 Identities = 24/61 (39%), Positives = 32/61 (52%), Gaps = 11/61 (18%)

Query: 1036 CPK-DLKPVCGDDGQTYNNPCML----CHENLIRQTNTHIRSTGKCEESSTPGT--TAAS 1088
            CP+ +   VCG DG TY N C L    C + L       I+S G C+E+  P T  T+AS
Sbjct: 928  CPEANATKVCGSDGVTYGNECQLKTIACRQGL----QISIQSLGPCQEAVAPSTHPTSAS 983

Query: 1089 M 1089
            +
Sbjct: 984  V 984



 Score = 38.1 bits (87), Expect = 0.046
 Identities = 18/45 (40%), Positives = 25/45 (55%), Gaps = 1/45 (2%)

Query: 111 CPDYYEA-VCGTDGKTYDNRCALCAENAKTGSQIGVKSEGECKSS 154
           CP+     VCG+DG TY N C L     + G QI ++S G C+ +
Sbjct: 928 CPEANATKVCGSDGVTYGNECQLKTIACRQGLQISIQSLGPCQEA 972



 Score = 31.6 bits (70), Expect = 4.3
 Identities = 17/56 (30%), Positives = 27/56 (48%), Gaps = 1/56 (1%)

Query: 98  DDFKKGERDGDFICPDYYEA-VCGTDGKTYDNRCALCAENAKTGSQIGVKSEGECK 152
           +D + G    DF C     + VCG+DG TY   C L     ++   + V ++G C+
Sbjct: 696 EDSEDGPCVCDFSCQSVPGSPVCGSDGVTYSTECELKKARCESQRGLYVAAQGACR 751


>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
           sapiens]
          Length = 600

 Score = 60.8 bits (146), Expect = 7e-09
 Identities = 71/329 (21%), Positives = 133/329 (40%), Gaps = 22/329 (6%)

Query: 608 QQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCAM 667
           +Q  KE+ R + R   +RE E+E  +  R    +G+    R+ D  +  + +T   +   
Sbjct: 115 RQREKERNRQKER---ERETEREG-ERGRDRQTDGQRERERQRDAEKERERQTDRERQRQ 170

Query: 668 CKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDP 727
            +   QKE E  K ++E  +R       +     +++      RE+         R++D 
Sbjct: 171 TERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDR 230

Query: 728 VRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKLI 787
            RD   K+   +    +A+ ER +ER+ E  + R      +  +D     R Q +     
Sbjct: 231 ERDRQRKTEREREK--QAERERASERETERDKERERERDRDRDRD-----RRQKE----- 278

Query: 788 CTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGERSNDKED 847
             RE    R    +T  ++ T  K + +RE  E++++ +  R    ER    ER  + E 
Sbjct: 279 --RERQTDRKRQRRTERDRETERKRERQRER-ERERERNRKRERERERERERERQRETER 335

Query: 848 LCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREA---NERKKKDEEKS 904
              + R  +R  +    RE N   G  G+    +    +   DR++    E +++D ++ 
Sbjct: 336 DREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRD 395

Query: 905 SSKPSNNAKDQCRQVQNEAEDAKFRQPGR 933
             K      ++ R  Q E E  + R+  R
Sbjct: 396 RQKERERQTEKDRDGQRETEKQREREKDR 424



 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 55/264 (20%), Positives = 109/264 (41%), Gaps = 14/264 (5%)

Query: 673 QKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVRDAD 732
           QKE E R+ K + ++              + + +   +RE+ ++      R++D  RD  
Sbjct: 59  QKERERRREKRQTERETDRKRERRREKDRHRKRD--RHRERQRDREKERERQTDRERDRQ 116

Query: 733 GKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKLICTRES 792
            +   N+    + + ERE ER+ E  R R    G    +   D  + + +       R++
Sbjct: 117 REKERNR----QKERERETEREGERGRDRQTD-GQRERERQRDAEKERERQTDRERQRQT 171

Query: 793 DPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDR-SNTG-ERSNTGERSNDKEDLCR 850
           +  R  + +   N+    +E+ ERE   +K+ + EDR S  G ER    E   + E   +
Sbjct: 172 ERNRQKEREREKNR----QERRERERQREKENKTEDRHSERGRERERERETETETERKRQ 227

Query: 851 EFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREAN-ERKKKDEEKSSSKPS 909
             R   R  K    RE    R    +    +    +   DR+ + +R++K+ E+ + +  
Sbjct: 228 TDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKR 287

Query: 910 NNAKDQCRQVQNEAEDAKFRQPGR 933
               ++ R+ + + E  + R+  R
Sbjct: 288 QRRTERDRETERKRERQRERERER 311



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 69/392 (17%), Positives = 149/392 (38%), Gaps = 47/392 (11%)

Query: 478 QQEERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFK 537
           +Q+ER R + KR+  +E   + R++ R       R+ +  R  D +    +         
Sbjct: 58  RQKERERRREKRQTERETDRK-RERRREKDRHRKRDRHRERQRDREKERER--------- 107

Query: 538 LEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHG 597
             + +++ D++ + +   +K +    +      R    +G+    R+ D  +  + +   
Sbjct: 108 --QTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDR 165

Query: 598 NTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPD 657
                 E   Q+E + ++  + R + +R+ EKE   E R   +       RE +  R  +
Sbjct: 166 ERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERG------RERERERETE 219

Query: 658 GKTHGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNG 717
            +T        K    +E + +++ E E ++ A    +S       ++   E        
Sbjct: 220 TETER------KRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRD 273

Query: 718 RLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEF 777
           R    RE    R    ++  ++ T  K + +RE ER+ E +R R      E  ++   E 
Sbjct: 274 RRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRET 333

Query: 778 -------RSQMKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAA----------- 819
                  R + +  +    RE +   G +G+    +    + + +R++A           
Sbjct: 334 ERDREKERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRD 393

Query: 820 -----EKKKKEDEDRSNTGERSNTGERSNDKE 846
                E++++ ++DR    E     ER  D+E
Sbjct: 394 RDRQKERERQTEKDRDGQRETEKQREREKDRE 425



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 101/494 (20%), Positives = 183/494 (37%), Gaps = 72/494 (14%)

Query: 343 EKKKAEARARNKRESGKATSYAELCSEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSM 402
           EK++ E     KRE  +          +R+  R+ +    R+ D  +    +   N    
Sbjct: 67  EKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNR--- 123

Query: 403 CEVFFQAEEEEKKKKEGKSRNKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPD 462
                Q E E + ++EG+    RQ+      E      ++  +       R+ +  +  +
Sbjct: 124 -----QKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKE 178

Query: 463 GKMHGNTCSMCEAFFQQEERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDG 522
            +   N         +QE R R   +R+  KE  +E R   R       RE    R  + 
Sbjct: 179 REREKN---------RQERRER---ERQREKENKTEDRHSERG------RERERERETET 220

Query: 523 KMHGNKCAMCASVFKLEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCT 582
           +    +           + +++ D++ K + E EK   +A +E  SE R   R+      
Sbjct: 221 ETERKR-----------QTDRERDRQRKTEREREK---QAERERASE-RETERDKERERE 265

Query: 583 RENDPIEGLDGKIHGNTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNG 642
           R+ D       K         E   Q + K + R E   + +R+ E++   E R   +N 
Sbjct: 266 RDRDRDRDRRQK---------ERERQTDRKRQRRTERDRETERKRERQRERE-RERERNR 315

Query: 643 KLFCTRENDPVRGPDGKTHGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGN 702
           K    RE +  R    +T  ++        +KE E +++++ E  R         G  G 
Sbjct: 316 KRERERERERERERQRETERDR--------EKERERKRKRQTEMDRE---RNRQTGREGR 364

Query: 703 TQDECAEYREQMKNGRLSCTRES-DPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSR 761
            Q E    RE+ ++ + +  RE  +  RD D +    + T      +RE E++ E  + R
Sbjct: 365 RQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQRETEKQREREKDR 424

Query: 762 SNGTGSESGKDTCDEFRSQMKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEK 821
            +  G E G++     R + K  +    R++D   G   K    + T+      R A   
Sbjct: 425 ESERGRERGRE-----REKQKGRERDRERQTDRQAGRQRK----RSTLYVNPPPRTARSG 475

Query: 822 KKKEDEDRSNTGER 835
             + D +R   G R
Sbjct: 476 VVQSDPNRPTRGIR 489



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 41/204 (20%), Positives = 79/204 (38%), Gaps = 23/204 (11%)

Query: 730 DADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKLICT 789
           D D +  N Q    + + +R+ ER+ +  R R         +   D  R + ++ +    
Sbjct: 50  DGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKR---DRHRERQRDREKERE 106

Query: 790 RESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGERSNDKEDLC 849
           R++D  R    +   N+    + + ERE  E+ +    D     ER    E+  +++   
Sbjct: 107 RQTDRERDRQREKERNRQKERERETERE-GERGRDRQTDGQRERERQRDAEKERERQTDR 165

Query: 850 REFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKDEEKSSSKPS 909
              R  +RN +    RE N                     +R   ER+++ E K+  + S
Sbjct: 166 ERQRQTERNRQKEREREKNRQ-------------------ERRERERQREKENKTEDRHS 206

Query: 910 NNAKDQCRQVQNEAEDAKFRQPGR 933
              +++ R+ + E E  + RQ  R
Sbjct: 207 ERGRERERERETETETERKRQTDR 230


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 60.8 bits (146), Expect = 7e-09
 Identities = 157/780 (20%), Positives = 281/780 (36%), Gaps = 175/780 (22%)

Query: 201  FLKEAENAKREGETRIRRNAEKDFCKEYEKQVRNGRLFCTRESDPVRGPDGRMHGNKCAL 260
            FL E E  ++    R  R  E  F +E E+  R  R    +E +     DG     +   
Sbjct: 810  FLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEE-----DGLQEDQE--- 861

Query: 261  CAEIFKQRFSEENSKTDQNLGKAEEKTKVKREIVKLCSQYQNQAKNGILFCTRENDPIRG 320
                  +R S+E  +  +   + EE+ K +R  +      Q Q +        E + ++ 
Sbjct: 862  ------RRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQR 915

Query: 321  PDGKMHGNLCSMCQ----AYFQAENE-------EKKKAEARARNKRESGKATSYAE--LC 367
             + +         Q       Q E E       EK++ + R R  R+  K     E  L 
Sbjct: 916  EEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLG 975

Query: 368  SEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNKRQS 427
             E  K  R  +    RE + +Q  +           E   + E E+++++E + + +++ 
Sbjct: 976  EEPEKRRRQEREKKYREEEELQQEE-----------EQLLREEREKRRRQEWERQYRKKD 1024

Query: 428  KSTASFEELCSEYRKSRK-NGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQEERARAK 486
            +     E+L  E R+ R+   R    RE + +Q  + ++ G          ++E R R +
Sbjct: 1025 ELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGE---------ERETRRRQE 1075

Query: 487  AKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFKLEEEEKKND 546
             +R+  KE      ++++       RE      P+ +    +   C      EEEE + +
Sbjct: 1076 LERQYRKE------EELQQEEEQLLREE-----PEKRRRQERERQCR-----EEEELQQE 1119

Query: 547  KEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTCSMCEAF 606
            +E+  + E EK +R   QEL  +YR                                E  
Sbjct: 1120 EEQLLREEREKRRR---QELERQYRE-------------------------------EEE 1145

Query: 607  FQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCA 666
             QQE ++  R EP  + ++E E++  +E    LQ  +    RE    R            
Sbjct: 1146 VQQEEEQLLREEPEKRRRQELERQYREEEE--LQQEEEQLLREEQEKR------------ 1191

Query: 667  MCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESD 726
                  ++E E + R+EEE QR               Q     YR++ +   L    E +
Sbjct: 1192 ------RQERERQYREEEELQR---------------QKRKQRYRDEDQRSDLKWQWEPE 1230

Query: 727  PVRDA-DGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGK 785
                  D K Y      CK + E E  R+ E S+ R      +S +D       Q +   
Sbjct: 1231 KENAVRDNKVY------CKGR-ENEQFRQLEDSQLRDR----QSQQDLQHLLGEQQERD- 1278

Query: 786  LICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGERSNDK 845
                RE +  R      H  +    +E+LERE  E+K+ +  DR +  E+    E   +K
Sbjct: 1279 ----REQERRRWQQRDRHFPE----EEQLERE--EQKEAKRRDRKSQEEKQLLREEREEK 1328

Query: 846  EDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKDEEKSS 905
                   R  +   +L+  RE  P+R                   R+  +RK ++EE   
Sbjct: 1329 RRRQETDRKFREEEQLLQEREEQPLR-------------------RQERDRKFREEELRH 1369

Query: 906  SKPSNNAKDQCRQVQNEAEDAKFRQPGRSLASVARMSTDECSEFRNYIRNNELICPREND 965
             +      ++ ++++ +  + KF +  + L    R         R +    + +  +E D
Sbjct: 1370 QEQGRKFLEEEQRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERD 1429



 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 142/768 (18%), Positives = 284/768 (36%), Gaps = 134/768 (17%)

Query: 177  RENDPVLGPDGKTHGNKCAMCAELFLKEAENAKREGETRIRRNAEKDFCKEYEKQVRNGR 236
            +E + +LG + +T   +     E   ++ E  ++E E  +R   EK   +E E+Q R   
Sbjct: 1058 QEEEQLLGEERETRRRQEL---ERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEE 1114

Query: 237  LFCTRESDPVRGPDGRMHGNKCALCAEIFKQRFSEENSKTDQNLGKAEEKTKVKREIVKL 296
                 E   +R    +          E+ +Q   EE  + ++     EE  K +R+ ++ 
Sbjct: 1115 ELQQEEEQLLREEREKRRRQ------ELERQYREEEEVQQEEEQLLREEPEKRRRQELER 1168

Query: 297  CSQYQNQAKNGILFCTRENDPIRGPDGKMHGNLCSMCQAYFQAENEEKKKAEARARNKRE 356
              + + + +       RE    R  + +               E EE ++ + + R + E
Sbjct: 1169 QYREEEELQQEEEQLLREEQEKRRQERERQ-----------YREEEELQRQKRKQRYRDE 1217

Query: 357  SGKATSYAELCSEYRKLVRNGKLACT-RENDPI-QGPDGKVHGNTCSMCEVFFQAEEEEK 414
              ++    +   E    VR+ K+ C  REN+   Q  D ++              E++E+
Sbjct: 1218 DQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQER 1277

Query: 415  KKKEGKSRNKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCE 474
             +++ + R +++ +     E+L  E +K  K                D K      S  E
Sbjct: 1278 DREQERRRWQQRDRHFPEEEQLEREEQKEAKRR--------------DRK------SQEE 1317

Query: 475  AFFQQEERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGP--DGKMHGNKCAMC 532
                +EER   + ++E  ++    FR++ +   L+  RE  P+R    D K    +    
Sbjct: 1318 KQLLREEREEKRRRQETDRK----FREEEQ---LLQEREEQPLRRQERDRKFREEELRHQ 1370

Query: 533  ASVFKLEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLD 592
                K  EEE++  ++E+ +    K  +E  Q  C E    +R  R    RE +      
Sbjct: 1371 EQGRKFLEEEQRLRRQERER----KFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQ 1426

Query: 593  GKIHGNTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDP 652
             +         +  F++E ++  R E   K   E ++   +  R+  +  +L   RE   
Sbjct: 1427 ER---------DRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQ 1477

Query: 653  VRGPDGKTHGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYRE 712
            +                    ++  +RK  EEE Q                Q+   ++RE
Sbjct: 1478 LH-------------------RQERDRKFLEEEQQLRR-------------QERDRKFRE 1505

Query: 713  QMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKD 772
            Q         R  +P R    K    +  + + + +R+  ++ +  R +  G      +D
Sbjct: 1506 QE-------LRSQEPER----KFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRD 1554

Query: 773  TCDEFRSQMKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDED--RS 830
               +FR + +       R+    +    +    K  + ++K+ R+  E+K  EDE   R 
Sbjct: 1555 R--KFREEEQ------LRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRR 1606

Query: 831  NTGERSNTGERS---NDKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQS 887
              G++    ER     + E L +E    Q +      R+    +    +  + +    Q 
Sbjct: 1607 QEGQQQLRQERDRKFREDEQLLQEREEQQLH------RQERDRKFLEEEPQLRRQEREQQ 1660

Query: 888  IFDREANERKKKDEEKSSSKPSNNAKDQCRQVQNEAEDAKFRQPGRSL 935
            +  R   +RK ++EE+   +         +Q++ +  D KFR+  + L
Sbjct: 1661 L--RHDRDRKFREEEQLLQEGEE------QQLRRQERDRKFREEEQQL 1700



 Score = 35.8 bits (81), Expect = 0.23
 Identities = 101/568 (17%), Positives = 209/568 (36%), Gaps = 80/568 (14%)

Query: 410  EEEEKKKKEGKSRNKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNT 469
            +EEE++++  K   + + +     E+     ++ R+  RL    E + +Q          
Sbjct: 480  QEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQ-------RL 532

Query: 470  CSMCEAFFQQEERARAKAKREAAKEICSEFRDQ-------VRNGTLICTREHNPVR--GP 520
             S  +   +QEER     KRE  K +  E R+Q        R   L+   E    +    
Sbjct: 533  RSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKR 592

Query: 521  DGKMHGNKCAMCASVFKLEEEEKKNDKEEKGKVEAEK--------VKREAVQELCSEYRH 572
            + +    +      V +LE+EE++  + ++ + E E+         + E  Q+     + 
Sbjct: 593  EQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQ 652

Query: 573  YVRNGRLPCTRENDPIEGLDGKIHGNTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETC 632
              R  RL    E + +E    + H           ++E +E+E AE   +  RE  K   
Sbjct: 653  ERREQRLKREEEEERLEQRLKREH-----------EEERREQELAEEEQEQARERIKSRI 701

Query: 633  DEFRRLLQN------GKLFC-TRENDPVRGPDGKTHGNKCAMCKAVFQKENEERKRKEEE 685
             +++  L++       K++   R+ +  R    +    +    +  +Q+E    ++++EE
Sbjct: 702  PKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEE 761

Query: 686  DQR-------NAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVRDADGKSYNN 738
            +QR        A      G    + +    E RE+         RE   + + + K    
Sbjct: 762  EQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRR 821

Query: 739  QCTMCKAK----LERE------------AERKNEYSRSRSNGTGSESGKDTCDEFRSQMK 782
            +    + K    LE E             E ++     +      E  +D    ++ + +
Sbjct: 822  RQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEE 881

Query: 783  NGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGERS 842
              +   T  + P      +         +E+L+RE  EK+++++++R    E     +  
Sbjct: 882  RKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEE----QLQ 937

Query: 843  NDKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKDEE 902
             ++E L RE R  +R  +    RE       Y K    K    +     E  E++++ E 
Sbjct: 938  QEEEQLLREEREKRRRQE----RERQ-----YRK--DKKLQQKEEQLLGEEPEKRRRQER 986

Query: 903  KSSSKPSNNAKDQCRQVQNEAEDAKFRQ 930
            +   +     + +  Q+  E  + + RQ
Sbjct: 987  EKKYREEEELQQEEEQLLREEREKRRRQ 1014



 Score = 35.0 bits (79), Expect = 0.39
 Identities = 50/258 (19%), Positives = 101/258 (39%), Gaps = 24/258 (9%)

Query: 411  EEEKKKKEGKSRNKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTC 470
            EEE+  +EG+ +  R+ +    F E   + R+  +  +    +E   ++  +        
Sbjct: 1671 EEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFL--QEEQQLRRQE-------- 1720

Query: 471  SMCEAFFQQEERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCA 530
               E  F++EE+ R + ++E  +     +R  +    L   RE   +R  +      K  
Sbjct: 1721 --LERKFREEEQLRQETEQEQLRR-QERYRKILEEEQLRPEREEQQLRRQE---RDRKFR 1774

Query: 531  MCASVFKLEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEG 590
                + +  EE++   +E   K   E+  R+  +E   + R   R+G+     E   +E 
Sbjct: 1775 EEEQLRQEREEQQLRSQESDRKFREEEQLRQEREE--QQLRPQQRDGKYRWEEEQLQLEE 1832

Query: 591  LDGKIHGNTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRL------LQNGKL 644
             + ++         A  Q   +EK R E +   + E +K   +  R+L       Q  + 
Sbjct: 1833 QEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEE 1892

Query: 645  FCTRENDPVRGPDGKTHG 662
               R+   ++  +GK HG
Sbjct: 1893 QRHRQVGEIKSQEGKGHG 1910



 Score = 32.3 bits (72), Expect = 2.5
 Identities = 108/568 (19%), Positives = 204/568 (35%), Gaps = 87/568 (15%)

Query: 410 EEEEKKKKEGKSRN-------KRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPD 462
           +EE++++ E + R        +R+ K      EL     +S K  RL    E    Q  D
Sbjct: 115 QEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERL----EQRDRQRRD 170

Query: 463 GKMHGNTCSMCEAFFQQEERARAKAKREAAKEICSEFRD--QVRNGTLICTREHNPVRGP 520
            ++        E   ++E RA  +  +        EF D  Q+R   L+  R     +G 
Sbjct: 171 EELWRQRQEWQE---REERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRR----KGR 223

Query: 521 DGKMHGNKCAMCASVFKLEEEEKKNDKEEKGKVEAEKVKREAVQ---ELCSEYRHYVRNG 577
           + K    +      VF+ EEE++   +E   + E EK++ E  Q   EL  E     +  
Sbjct: 224 EEKQQQRRERQ-DRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE 282

Query: 578 RLPCTRENDPIEGLDGKIHGNTC-----------SMCEAFFQQEAKEKERAEPRAKVKRE 626
           R    RE    E    ++                   E   QQE +E++      +++RE
Sbjct: 283 RQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRRE 342

Query: 627 AEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCAMCKAVFQKENEERKRKEEED 686
            E+    + RR  +  +    RE    R  + +    +    +   Q   E++ R+E++ 
Sbjct: 343 QEERREQQLRREQEEER----REQQLRREQEEERREQQ---LRREQQLRREQQLRREQQL 395

Query: 687 QRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVRDADGKSY--NNQCTMCK 744
           +R               + E    REQ         RE    R+ + + +   ++    +
Sbjct: 396 RREQ-----------QLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERRE 444

Query: 745 AKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKLICTRESDPVRGPDGKTHG 804
            +L+RE E + ++ +        E+ +   +  + Q+K                D +   
Sbjct: 445 QRLKREQEERRDWLKRE-----EETERHEQERRKQQLKR---------------DQEEER 484

Query: 805 NKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGERSNDKEDLCREFRSMQRNGKLICT 864
            +  +  E+ ER   ++++++   R     R    +R  ++E L +  RS Q+       
Sbjct: 485 RERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQ-----LR 539

Query: 865 RENNPVRGPYGKMHINK---CAMCQSIFDREANERK----KKDEEKSSSKPSNNAKDQCR 917
           RE    R    K    K       +    RE  ER+    K++EE+   +     +++  
Sbjct: 540 REQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLE 599

Query: 918 QVQNEAEDAKFRQPGRSLASVARMSTDE 945
           Q     E  +  Q  R    + R   +E
Sbjct: 600 QRLKREEVERLEQEERREQRLKREEPEE 627


>gi|148839339 nexilin (F actin binding protein) [Homo sapiens]
          Length = 675

 Score = 57.4 bits (137), Expect = 7e-08
 Identities = 117/526 (22%), Positives = 212/526 (40%), Gaps = 90/526 (17%)

Query: 262 AEIFKQRFSEENSKTDQNLGKAEE-----KTKVKREIVKLCSQYQNQAKNGILFCTREND 316
           AE+ KQR  E+  +T++   +  E     K K++RE+ K   Q ++    G    + E D
Sbjct: 107 AEMEKQRQEEQRKRTEEERKRRIEQDMLEKRKIQRELAKRAEQIEDINNTGTESASEEGD 166

Query: 317 --------PIRG--PDGKMHGNLCSMCQAYFQAENEEKKKAEARARNKRESGKATSYAEL 366
                   P++     GKM  N             + +K+ E + R K E  K   Y   
Sbjct: 167 DSLLITVVPVKSYKTSGKMKKNF-----------EDLEKEREEKERIKYEEDKRIRY--- 212

Query: 367 CSEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAE---EEEKKKKEGKSRN 423
             E R  ++  K      +D I+    K   +   +   F + E   +E +KK+  +   
Sbjct: 213 -EEQRPSLKEAKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEAR 271

Query: 424 KRQSKSTASFEE----LCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQ 479
           KR  +   +FEE    + +E  +++   ++F            GK+     S  E   Q+
Sbjct: 272 KRLEEEKRAFEEARRQMVNEDEENQDTAKIFKGYR-------PGKL---KLSFEEMERQR 321

Query: 480 EERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRG--------PDGKMHGNKCAM 531
            E  + KA+ EA + I  E +        +   + +P             GK+  N   +
Sbjct: 322 REDEKRKAEEEARRRIEEEKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGKLEINFEEL 381

Query: 532 CASVFKLEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGL 591
                K+EEE+++ ++E K K+E EK + E +++   E      N     +RE + +  L
Sbjct: 382 LKQ--KMEEEKRRTEEERKHKLEMEKQEFEQLRQEMGEEEE--ENETFGLSREYEELIKL 437

Query: 592 --DGKIHG-NTCSMCEAFFQ------QEAKEKERAEPRA---KVK-REAE---KETCDEF 635
              G I   N  S  E   Q      Q+  E+ERA  RA   ++K REAE   +E   + 
Sbjct: 438 KRSGSIQAKNLKSKFEKIGQLSEKEIQKKIEEERARRRAIDLEIKEREAENFHEEDDVDV 497

Query: 636 RRLLQNGKLFCTREN--------DPVRGPDGKTHGNKCAMCKAVFQKEN----EERKRKE 683
           R   ++   F  + N           R  + +    +  + +  F++       ++KR+E
Sbjct: 498 RPARKSEAPFTHKVNMKARFEQMAKAREEEEQRRIEEQKLLRMQFEQREIDAALQKKREE 557

Query: 684 EEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVR 729
           EE++  +  +GS+      T+     +++ +KN   +   +S+PVR
Sbjct: 558 EEEEEGSIMNGSTAEDEEQTRSGAPWFKKPLKN---TSVVDSEPVR 600



 Score = 38.5 bits (88), Expect = 0.035
 Identities = 60/274 (21%), Positives = 101/274 (36%), Gaps = 25/274 (9%)

Query: 673 QKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKN----GRLSCTRESDP- 727
           Q++ E+RKR EEE +R               Q E A+  EQ+++    G  S + E D  
Sbjct: 112 QRQEEQRKRTEEERKRRIEQDMLE---KRKIQRELAKRAEQIEDINNTGTESASEEGDDS 168

Query: 728 --VRDADGKSYNNQCTMCK--AKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKN 783
             +     KSY     M K    LE+E E K             E  +   +E R  +K 
Sbjct: 169 LLITVVPVKSYKTSGKMKKNFEDLEKEREEKERIKY-------EEDKRIRYEEQRPSLKE 221

Query: 784 GKLICTRESDPVRGPDGK--THGNKCTMCKEKLEREAAEKKKK--EDEDRSNTGERSNTG 839
            K +     D +     K      K  +  E+LER+  E +KK  E+E R    E     
Sbjct: 222 AKCLSLVMDDEIESEAKKESLSPGKLKLTFEELERQRQENRKKQAEEEARKRLEEEKRAF 281

Query: 840 ERSNDKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKK 899
           E +  +  +  E    Q   K+        ++  + +M   +    +   + EA  R ++
Sbjct: 282 EEA--RRQMVNEDEENQDTAKIFKGYRPGKLKLSFEEMERQRREDEKRKAEEEARRRIEE 339

Query: 900 DEEKSSSKPSNNAKDQCRQVQNEAEDAKFRQPGR 933
           +++  +    N   D       +    +F  PG+
Sbjct: 340 EKKAFAEARRNMVVDDDSPEMYKTISQEFLTPGK 373


>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
           protein 6 [Homo sapiens]
          Length = 724

 Score = 53.5 bits (127), Expect = 1e-06
 Identities = 75/373 (20%), Positives = 152/373 (40%), Gaps = 39/373 (10%)

Query: 202 LKEAENAKREGETRIRRNAEKDFCKEYEKQVRNGRLFCTRESDPVRGPDGRMHGNKCALC 261
           ++E E   RE E ++RR  E  + KE EK  R   +   +E         +M   +  + 
Sbjct: 384 IREQEEKIREQEEKMRRQEEMMWEKE-EKMRRQEEMMWEKEE--------KMRRQEEMMW 434

Query: 262 AEIFKQRFSEENSKTDQNLGKAEEKTKVKREIVKLCSQYQNQAKNGILFCTRENDPIRGP 321
            +  K R  EE     + + + EEK + + +I +   + + +AK       R+ + IR  
Sbjct: 435 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAK-----MWRQEEKIREQ 489

Query: 322 DGKMHGNLCSMCQAYFQAENEEKKKAEARARNKRESGKATSYAELCSEYRKLVRNGKLAC 381
           + K+      M +   +   +EK + E + + + E  +     E   E  ++        
Sbjct: 490 EEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE---EKIREQEEI-------- 538

Query: 382 TRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNKRQSKSTASFEELCSEYR 441
            R+ + I   + K+      M     +  ++E+K +E + +  RQ +     EE   E  
Sbjct: 539 WRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQE 598

Query: 442 KSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQEERARAKAK--REAAKEICSEF 499
           +  +        + + +   + KM    C   E   +QEE+ R + +  RE  K+I  E 
Sbjct: 599 EKIREQEEMTQEQEEKMGEQEEKM----CEQEEKMQEQEEKMRRQEEKIREQEKKI-REQ 653

Query: 500 RDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFKLEEEEKKNDKEEKGKVEAEKVK 559
            +++R        +   ++  + KM   +  MC    K++E+E+K  ++E+   E E   
Sbjct: 654 EEKIRE-------QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRL 706

Query: 560 REAVQELCSEYRH 572
           R+  +++     H
Sbjct: 707 RQQEEKMQEHQEH 719



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 67/398 (16%), Positives = 156/398 (39%), Gaps = 70/398 (17%)

Query: 539 EEEEKKNDKEEKGKVEAEKVKRE------------AVQELCSEYRHYVRNGRLPCTREND 586
           E+EEK  ++EEK + + EK++R+              +E+  E    +R        + +
Sbjct: 379 EQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEE 438

Query: 587 PIEGLDGKIHGNTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFC 646
            I  L+ K+H           Q++ +E+E        KR+ E++  ++ +R  Q  K++ 
Sbjct: 439 KIRELEEKMHE----------QEKIREQEE-------KRQEEEKIREQEKRQEQEAKMW- 480

Query: 647 TRENDPVRGPDGKTHGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDE 706
            R+ + +R  + K    +  M +   +   +E+ R+EE+ Q                Q+E
Sbjct: 481 -RQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMW---------RQEE 530

Query: 707 CAEYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTG 766
               +E++   +     + + +R  + K +  +  M   + +   + +  + +       
Sbjct: 531 KIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQ 590

Query: 767 SESGKDTCDEFRSQMKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKED 826
            E  ++  ++ R Q +      T+E +   G   +       MC+++ + +  E+K +  
Sbjct: 591 EEKIREQEEKIREQEE-----MTQEQEEKMGEQEE------KMCEQEEKMQEQEEKMRRQ 639

Query: 827 EDRSNTGERSNTGERSNDKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQ 886
           E++    E+     +  ++E+  RE   M +  +               KM   +  MC+
Sbjct: 640 EEKIREQEK-----KIREQEEKIREQEEMMQEQE--------------EKMWEQEEKMCE 680

Query: 887 SIFDREANERKKKDEEKSSSKPSNNAKDQCRQVQNEAE 924
                +  E K + +E+   +     + Q  ++Q   E
Sbjct: 681 QEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQE 718


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 51.6 bits (122), Expect = 4e-06
 Identities = 92/459 (20%), Positives = 190/459 (41%), Gaps = 50/459 (10%)

Query: 202 LKEAENAKREGETRIRRNAEKDFCKEYEKQVRNGRLFCTRESDPVRGPD------GRMHG 255
           ++E E   RE E ++RR  E  + KE EK  R   +   +E    R  +       +M  
Sbjct: 323 IREQEEKIREQEEKMRRQEEMMWEKE-EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRR 381

Query: 256 NKCALCAEIFKQRFSEENSKTDQNLGKAEEKTKVKREIVKLCSQYQNQAKNGILFCTREN 315
            +  +  +  K R  EE     + + + EEK + + +I +   + + +AK       R+ 
Sbjct: 382 QEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAK-----MWRQE 436

Query: 316 DPIRGPDGKMHGNLCSMCQAYFQAENEEKKKAEARARNKRESGKATSYAELCSEYRKLVR 375
           + IR  + K+      M +   +   +EK + E + + + E  +     E   E  ++ R
Sbjct: 437 EKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQE---EKIHEQEEIWR 493

Query: 376 NGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKK--KKEGKSRNK----RQSKS 429
             K     + + I+  + KV      + E   +  E+E+K  ++E K R +    R+ + 
Sbjct: 494 Q-KEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEK 552

Query: 430 TASFEELCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQEERARAKAKR 489
               E++  E ++  +  +++  R+ + I+  + K+      + E   +++E+     K+
Sbjct: 553 MHEQEKIWEEEKRQEQEDKMW--RQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQ 610

Query: 490 EAA----KEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFKLEEEEKKN 545
           E      +E   E  +++R        +    +  + KM   +  MC    K++E+E+  
Sbjct: 611 EEKIREQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETM 670

Query: 546 DKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTCSMCEA 605
            ++E+   E EK  RE  +++                 + + ++  + K+      MCE 
Sbjct: 671 WRQEEKIREQEKKIREQEEKI---------------REQEEMMQEQEEKMWEQEEKMCE- 714

Query: 606 FFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKL 644
              QE K +E+ E   K++R+ EK    E R   Q  K+
Sbjct: 715 ---QEEKMQEQEE---KMRRQEEKMWEQEVRLRQQEEKM 747



 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 77/429 (17%), Positives = 174/429 (40%), Gaps = 45/429 (10%)

Query: 539 EEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGN 598
           E+EEK  ++EEK + + EK++R+  +E+  E    +R        + + +   +  +   
Sbjct: 318 EQEEKIREQEEKIREQEEKMRRQ--EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK 375

Query: 599 TCSMC---EAFFQQEAKEKERAEP--------RAKVKREAEKETCDEFRRLLQNGKLFCT 647
              M    E  +++E K +E  E           + KR+ E++  ++ +R  Q  K++  
Sbjct: 376 EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMW-- 433

Query: 648 RENDPVRGPDGKTHGNKCAMCKA-----VFQKENEERKRKEEEDQRNAAGHGSSGGGGGN 702
           R+ + +R  + K    +  M +        +K  EE KR+E+E+                
Sbjct: 434 RQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWR 493

Query: 703 TQDECAEYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRS 762
            +++  E  E+++       R+ + +R+ + K    +      K+ R+ E+  E      
Sbjct: 494 QKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQE-----EKMWRQEEKIREQEEMWR 548

Query: 763 NGTGSESGKDTCDEFRSQMKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKK 822
                   +   +E + Q +  K+   R+ + +R  + K    +  + +++ +R+  E+K
Sbjct: 549 EEEKMHEQEKIWEEEKRQEQEDKM--WRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEK 606

Query: 823 --KKEDEDRSNTGERSNTGERSNDKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHIN 880
             K+E++ R    +     E+  ++E+  RE   M        T+E        G+    
Sbjct: 607 MWKQEEKIREQEEKIQEQEEKIREQEEKIREQEEM--------TQEQEE---KMGEQEEK 655

Query: 881 KCAMCQSIFDRE----ANERKKKDEEKSSSKPSNNAKDQCRQVQNEAEDAKFRQPGRSLA 936
            C   + + ++E      E K +++EK   +     ++Q  ++  E E+  + Q  +   
Sbjct: 656 MCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQ-EEMMQEQEEKMWEQEEKMCE 714

Query: 937 SVARMSTDE 945
              +M   E
Sbjct: 715 QEEKMQEQE 723



 Score = 32.0 bits (71), Expect = 3.3
 Identities = 46/256 (17%), Positives = 99/256 (38%), Gaps = 20/256 (7%)

Query: 202 LKEAENAKREGETRIRRNAEKDFCKEYEKQVRNGRLFCTRESDPVRGPDG------RMHG 255
           + E E   R+ E ++ R  EK   +E E+++R       R+ + +R  +       +MH 
Sbjct: 498 MHEQEEKIRKQEEKVWRQEEK--IREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHE 555

Query: 256 NKCALCAEIFKQRFSEENSKTDQNLGKAEEKT-----KVKREIVKLCSQYQNQAKNGILF 310
            +  +  E  +Q   ++  + ++ + + EEK      K++ +  K   Q +   K     
Sbjct: 556 QE-KIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKI 614

Query: 311 CTREN------DPIRGPDGKMHGNLCSMCQAYFQAENEEKKKAEARARNKRESGKATSYA 364
             +E       + IR  + K+        +   +   +E+K  E   + + +        
Sbjct: 615 REQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQE 674

Query: 365 ELCSEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNK 424
           E   E  K +R  +     + + +Q  + K+      MCE   + +E+E+K +  + +  
Sbjct: 675 EKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMW 734

Query: 425 RQSKSTASFEELCSEY 440
            Q       EE   E+
Sbjct: 735 EQEVRLRQQEEKMQEH 750


>gi|45505132 serine protease inhibitor, Kazal type 1 precursor [Homo
            sapiens]
          Length = 79

 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 22/41 (53%), Positives = 26/41 (63%)

Query: 1036 CPKDLKPVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKC 1076
            C K   PVCG DG TY N C+LC EN  RQT+  I+ +G C
Sbjct: 39   CTKIYDPVCGTDGNTYPNECVLCFENRKRQTSILIQKSGPC 79



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 20/41 (48%), Positives = 24/41 (58%)

Query: 111 CPDYYEAVCGTDGKTYDNRCALCAENAKTGSQIGVKSEGEC 151
           C   Y+ VCGTDG TY N C LC EN K  + I ++  G C
Sbjct: 39  CTKIYDPVCGTDGNTYPNECVLCFENRKRQTSILIQKSGPC 79



 Score = 38.1 bits (87), Expect = 0.046
 Identities = 18/46 (39%), Positives = 26/46 (56%), Gaps = 7/46 (15%)

Query: 174 GCTRENDPVLGPDGKTHGNKCAMCAELFLKEAENAKREGETRIRRN 219
           GCT+  DPV G DG T+ N+C +C        EN KR+    I+++
Sbjct: 38  GCTKIYDPVCGTDGNTYPNECVLC-------FENRKRQTSILIQKS 76



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 14/32 (43%), Positives = 21/32 (65%)

Query: 788 CTRESDPVRGPDGKTHGNKCTMCKEKLEREAA 819
           CT+  DPV G DG T+ N+C +C E  +R+ +
Sbjct: 39  CTKIYDPVCGTDGNTYPNECVLCFENRKRQTS 70



 Score = 34.3 bits (77), Expect = 0.66
 Identities = 16/50 (32%), Positives = 24/50 (48%)

Query: 701 GNTQDECAEYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKLERE 750
           GNT  +      +  N    CT+  DPV   DG +Y N+C +C    +R+
Sbjct: 19  GNTGADSLGREAKCYNELNGCTKIYDPVCGTDGNTYPNECVLCFENRKRQ 68



 Score = 33.9 bits (76), Expect = 0.86
 Identities = 15/32 (46%), Positives = 20/32 (62%)

Query: 239 CTRESDPVRGPDGRMHGNKCALCAEIFKQRFS 270
           CT+  DPV G DG  + N+C LC E  K++ S
Sbjct: 39  CTKIYDPVCGTDGNTYPNECVLCFENRKRQTS 70



 Score = 33.1 bits (74), Expect = 1.5
 Identities = 12/23 (52%), Positives = 16/23 (69%)

Query: 646 CTRENDPVRGPDGKTHGNKCAMC 668
           CT+  DPV G DG T+ N+C +C
Sbjct: 39  CTKIYDPVCGTDGNTYPNECVLC 61



 Score = 30.4 bits (67), Expect = 9.6
 Identities = 10/23 (43%), Positives = 16/23 (69%)

Query: 510 CTREHNPVRGPDGKMHGNKCAMC 532
           CT+ ++PV G DG  + N+C +C
Sbjct: 39  CTKIYDPVCGTDGNTYPNECVLC 61



 Score = 30.4 bits (67), Expect = 9.6
 Identities = 11/23 (47%), Positives = 14/23 (60%)

Query: 960 CPRENDPVHGADGKFYTNKCYMC 982
           C +  DPV G DG  Y N+C +C
Sbjct: 39  CTKIYDPVCGTDGNTYPNECVLC 61


>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
           sapiens]
          Length = 570

 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 65/308 (21%), Positives = 127/308 (41%), Gaps = 41/308 (13%)

Query: 340 ENEEKKKAEARARNKRESGKATSYAELCSEYRKLVRNGKLACTRENDPIQGPDGKVHGNT 399
           +  E+K  E   + + +  K     E+  E  + +R  +     + + I+  + K+H   
Sbjct: 298 QEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQ- 356

Query: 400 CSMCEVFFQAEE---EEKKKKEGKSRNKRQSKSTASFEELCSEYRKSRKNGRLFCTREND 456
               E   + EE   EE+K +E + R ++++K     E++  +  K R+        + +
Sbjct: 357 ----EKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIRE--------QEE 404

Query: 457 PIQGPDGKMHGNTCSMCEAFFQQEERARAKAKREAAKEICSEFRDQVRNGTLICTREHNP 516
            +Q  + KM      M E   Q+EE    + K    +E   E   ++R        +   
Sbjct: 405 MMQEQEEKMGEQEEKMWE---QEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEM 461

Query: 517 VRGPDGKMHGNKCAMCASVFKLEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRN 576
           ++  + KM   +  MC    K++E+E+K  ++E+   E EK  RE  +++          
Sbjct: 462 MQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKI---------- 511

Query: 577 GRLPCTRENDPIEGLDGKIHGNTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFR 636
                  + + ++  + K+      MCE    QE K +E+ E   K++R+ EK    E R
Sbjct: 512 -----REQEEMMQEQEEKMWEQEEKMCE----QEEKMQEQEE---KMRRQEEKMREQEVR 559

Query: 637 RLLQNGKL 644
              Q  K+
Sbjct: 560 LRQQEEKM 567



 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 56/286 (19%), Positives = 116/286 (40%), Gaps = 24/286 (8%)

Query: 213 ETRIRRNAEKDFCKEYEKQVRNGRLFCTRESDPVRGPDGRMHGNKCALCAEIFKQRFSEE 272
           E +I+   EK   +E E+++R       R+ + +   + +M   +  +  +  K R  EE
Sbjct: 294 EEKIQEREEK--IQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEE 351

Query: 273 NSKTDQNLGKAEEKTKVKREIVKLCSQYQNQAKNGILFCTRENDPIRGPDGKMHGNLCSM 332
                + + + EEK + + +I +   + + +AK       R+ + IR  + K+      M
Sbjct: 352 KMHEQEKIREQEEKRQEEEKIREQEKRQEQEAK-----MWRQEEKIREQEEKIREQEEMM 406

Query: 333 CQAYFQAENEEKKKAEARARNKRESGKATSYAELCSEYRKLVRNGKLACTRENDPIQGPD 392
            +   +   +E+K  E     + +  K     E   E  K +R  +     + + +Q  +
Sbjct: 407 QEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQE 466

Query: 393 GKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNKRQSKSTASFEELCSEYRKSRKNGRLFCT 452
            K+      MCE   + +E+E+K +  + + + Q K     EE   E             
Sbjct: 467 EKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIRE------------- 513

Query: 453 RENDPIQGPDGKMHGNTCSMC---EAFFQQEERARAKAKREAAKEI 495
            + + +Q  + KM      MC   E   +QEE+ R + ++   +E+
Sbjct: 514 -QEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMREQEV 558



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 49/219 (22%), Positives = 97/219 (44%), Gaps = 19/219 (8%)

Query: 478 QQEERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFK 537
           Q+E+  R + K +  +E   E  +++R       R+   +   + KM   +  M     K
Sbjct: 286 QEEKMWRQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 345

Query: 538 LEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHG 597
           + E E+K  ++E  K+  ++ KR+  +++  + +   +  ++   R+ + I   + KI  
Sbjct: 346 IRELEEKMHEQE--KIREQEEKRQEEEKIREQEKRQEQEAKM--WRQEEKIREQEEKIRE 401

Query: 598 NTCSMC---EAFFQQEAK----EKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTREN 650
               M    E   +QE K    E+E  E   K++R+ EK    E +   Q  K+   RE 
Sbjct: 402 QEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKI---REQ 458

Query: 651 DPVRGPD----GKTHGNKCAMCKAVFQKENEERKRKEEE 685
           + +        G+  G  C   +A  Q++ E+ +R+EE+
Sbjct: 459 EEMMQEQEEKMGEQEGKMCEQ-EAKMQEQEEKMRRQEEK 496



 Score = 38.9 bits (89), Expect = 0.027
 Identities = 54/269 (20%), Positives = 104/269 (38%), Gaps = 32/269 (11%)

Query: 202 LKEAENAKREGETRIRRNAEKDFCKEYEKQVRNGRLFCTRESDPVRGPDGRMHGNKCALC 261
           ++E E   RE E ++RR  E  + KE EK  R   +   +E + +R  + +MH  +    
Sbjct: 304 IQEQEEKIREQEEKMRRQEEMMWEKE-EKMRRQEEMMWEKE-EKIRELEEKMHEQEKIRE 361

Query: 262 AEIFKQ-----RFSEENSKTDQNLGKAEEKTKVKREIVKLCSQYQNQAKNGI-------- 308
            E  +Q     R  E+  + +  + + EEK + + E ++   +   + +  +        
Sbjct: 362 QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMW 421

Query: 309 ----------LFCTRENDPIRGPDGKMHGNLCSMC-QAYFQAENEEK------KKAEARA 351
                         R+ + IR  + K+      +  Q     E EEK      K  E  A
Sbjct: 422 EQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEA 481

Query: 352 RNKRESGKATSYAELCSEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEE 411
           + + +  K     E   E  K +R  +     + + +Q  + K+      MCE   + +E
Sbjct: 482 KMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQE 541

Query: 412 EEKKKKEGKSRNKRQSKSTASFEELCSEY 440
           +E+K +  + + + Q       EE   E+
Sbjct: 542 QEEKMRRQEEKMREQEVRLRQQEEKMQEH 570



 Score = 37.4 bits (85), Expect = 0.078
 Identities = 57/340 (16%), Positives = 125/340 (36%), Gaps = 50/340 (14%)

Query: 608 QQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCAM 667
           Q EA    +       K +A+ E  + + RL Q  +    R+ + ++  + K        
Sbjct: 252 QAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKI------- 304

Query: 668 CKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDP 727
                 +E EE+ R++EE  R               ++   E  E+M+        + + 
Sbjct: 305 ------QEQEEKIREQEEKMRRQ-------------EEMMWEKEEKMRRQEEMMWEKEEK 345

Query: 728 VRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKLI 787
           +R+ + K +  +      K+  + E++ E  + R             ++ + Q +  K+ 
Sbjct: 346 IRELEEKMHEQE------KIREQEEKRQEEEKIR-------------EQEKRQEQEAKM- 385

Query: 788 CTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERS--NTGERSNDK 845
             R+ + +R  + K    +  M +++ +    E+K  E E+     E       E+  ++
Sbjct: 386 -WRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQ 444

Query: 846 EDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKDEEKSS 905
           E   RE     R  + +   +   +    GKM   +  M +        E K +++EK  
Sbjct: 445 EKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKI 504

Query: 906 SKPSNNAKDQCRQVQNEAEDAKFRQPGRSLASVARMSTDE 945
            +     ++Q  ++  E E+  + Q  +      +M   E
Sbjct: 505 REQEEKIREQ-EEMMQEQEEKMWEQEEKMCEQEEKMQEQE 543


>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 828

 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 88/500 (17%), Positives = 203/500 (40%), Gaps = 65/500 (13%)

Query: 369 EYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNKRQSK 428
           E  K +R  +    R+ + ++  +GK+      M     +  E+EK+ +E +   + Q K
Sbjct: 245 EQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKK 304

Query: 429 STASFEELCSEYRKS---------------RKNGRLFCTRENDPIQGPDGKMHGNTCSMC 473
                E++  +  K                R+  RL+   +   ++  + KM        
Sbjct: 305 LREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLW--EQEKQMREQEQKMRDQE---- 358

Query: 474 EAFFQQEERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCA 533
           E  ++Q+ER R K +R   +E   E  ++++    I  RE   +R  +  M   +  M  
Sbjct: 359 ERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIRERE-KKMREEEETMREQEEKMQK 417

Query: 534 SVFKLEEEEKKNDKEEKGKVEAEKV-KREAVQELCSEYRHYVRNGRLPCTRENDPIEGLD 592
               + E+E+K  ++++   + EK+ ++E +QE   E + + +  ++   R+ + + G +
Sbjct: 418 QEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQE--QEEKIWEQEEKI---RDQEEMWGQE 472

Query: 593 GKI--HGNTCSMCEAFFQQEAK----------EKERAEPRAKVKREAEKETCDEFRRLLQ 640
            K+          +  ++QE K          ++ER   + +  RE E+   ++ +   Q
Sbjct: 473 KKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQ 532

Query: 641 NGKLFCTRENDPVRGPDGKTHGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGG 700
             K+   RE    +  + KT   +  M +    +E E++ R+EEE  R            
Sbjct: 533 EEKM---REEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMR------------ 577

Query: 701 GNTQDECAEYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRS 760
              +++  E  E+M+        + + +++ + K +  +  M + + E + + + E    
Sbjct: 578 -EQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWE 636

Query: 761 RSNGTGSESGKDTCDEFRSQMKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAE 820
           +         ++   E   +M   +     + + +R  + K  G +  M +++ + +  E
Sbjct: 637 Q---------EEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQE 687

Query: 821 KKKKEDEDRSNTGERSNTGE 840
           +K +E E++    E    G+
Sbjct: 688 EKMREQEEKMRGQEEKMWGQ 707



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 89/508 (17%), Positives = 199/508 (39%), Gaps = 52/508 (10%)

Query: 221 EKDFCKEYEKQVRNGRLFCTRESDPVRGPDGRMHGNKCALCAEIFKQRFSEENSKTDQNL 280
           +++  +E EK++R       R+ + +R  +G+M         E   +R  +   + ++ L
Sbjct: 239 QEEELREQEKKIRKQEEKMWRQEERLREQEGKMREQ------EEKMRRQEKRLREQEKEL 292

Query: 281 GKAEEKTKVKREIVKLCSQYQNQAKNGILFCTRENDPIRGPDGKMHGNLCSMCQAYFQAE 340
            + E++ + ++++ +   Q Q Q +        + + +R  + KM      + +   Q  
Sbjct: 293 REQEKELREQKKLREQEEQMQEQEEK----MWEQEEKMREQEEKMWRQEERLWEQEKQMR 348

Query: 341 NEEKKKAEARARNKRESGKATSYAELCSEYRKL------------VRNGKLACTRENDPI 388
            +E+K  +   R   +  +     E   E  K+            +R  +     E + +
Sbjct: 349 EQEQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETM 408

Query: 389 QGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNKRQSKSTASFEELCSEYRKSRKNGR 448
           +  + K+     +M E   + E ++++  E K +   Q K     E++  +  K R    
Sbjct: 409 REQEEKMQKQEENMWEQ-EEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEE 467

Query: 449 LF-----------CTRENDPIQGPDGKMHGNTCSMC---EAFFQQEERARAKAKREAAKE 494
           ++              + D +   + KM      M    E  ++Q+ER R K +R   ++
Sbjct: 468 MWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQK 527

Query: 495 ICSEFRDQVRNGTLICTRE------HNPVRGPDGKMHGNKCAMCASVFKLEEEEKKNDKE 548
              +  +++R       +E         +R  +      K          E+EEK  ++E
Sbjct: 528 KMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQE 587

Query: 549 EKGKVEAEKV--KREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTCSMC--- 603
           EK + + EK+  + E +QE   E + + +  ++    E D ++  +  +      M    
Sbjct: 588 EKMREQEEKMWEQEEKMQE--QEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQE 645

Query: 604 EAFFQQEAKEKERAEP--RAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKTH 661
           E  ++QE K +E+ E     + K + ++E   E    +Q  +     + + +RG + K  
Sbjct: 646 EKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMW 705

Query: 662 GNKCAMCKAVFQKENEERKRKEEEDQRN 689
           G +  M     +   +E  R++EE  R+
Sbjct: 706 GQEEKMWGQEEKMWGQEEMREKEERIRD 733



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 75/392 (19%), Positives = 153/392 (39%), Gaps = 29/392 (7%)

Query: 204 EAENAKREGETRIRRNA---EKDFCKEYEKQVRNGRLFCTRESDPVRGPDGRMHGNKCAL 260
           E +   RE E R+R      E++   + E+++R        E + +R  + +M   +  +
Sbjct: 363 EQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENM 422

Query: 261 CAEIFK----QRFSEENSKTDQNLGKAEEKTKVKREIVKLCSQYQNQAKNGILF----CT 312
             +  K    QR  E+  K  +     E++ K+  +  K+  Q +   +   ++      
Sbjct: 423 WEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMR 482

Query: 313 RENDPIRGPDGKMHGNLCSMCQAYFQAENEEKKKAEARARNKRESGKATSYAELCSEYRK 372
            + D +   + KM      M     +   ++++  E   R  RE  K     E   E +K
Sbjct: 483 EQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEER-MREQKKMWQQEEKMREEKK 541

Query: 373 LVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNKRQSKSTAS 432
                K    +E    +  + ++      M E      E+E+K +E + + + Q +    
Sbjct: 542 TQEQEKKTWDQEEKMRE--EERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWE 599

Query: 433 FEELCSEYRKS--RKNGRLFCTRENDPIQGPDGKMHGNTCSMCEA---FFQQEERARAKA 487
            EE   E  +    +  +++   E D +Q  +  M      M E     ++QEE+ R + 
Sbjct: 600 QEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQE 659

Query: 488 --------KREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFKLE 539
                   K +  +E   E  ++++        +   +RG + KM G +  M     K+ 
Sbjct: 660 EKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMW 719

Query: 540 EEEKKNDKEEKGKVEAEKVKREAV--QELCSE 569
            +E+  +KEE+ + + EK++      +E CSE
Sbjct: 720 GQEEMREKEERIRDQKEKMQERLPEHEERCSE 751



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 82/448 (18%), Positives = 172/448 (38%), Gaps = 47/448 (10%)

Query: 204 EAENAKREGETRIRRNAEKDFCKEYEKQVRNGRLFCTRESDPVRGPDGRMHGNKCALCAE 263
           E E   RE E ++ R  E+ +  E EKQ+R        + + +   D R+   K     E
Sbjct: 321 EQEEKMREQEEKMWRQEERLW--EQEKQMREQEQKMRDQEERMWEQDERLR-EKEERMRE 377

Query: 264 IFKQRFSEENSKTDQNLGKAEEKTKVKREIVKLCSQ-YQNQAKNGILFCTRENDPIRGPD 322
             K    EE  + ++ + + E+K + + E ++   +  Q Q +N      +E    R P+
Sbjct: 378 QEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPE 437

Query: 323 GKMHGNLCSMCQAYFQAENEEKKKAEARARNKRESGKATSYAELCSEYRKLVRNGKLACT 382
            K             +   E++K  E   +   +  K     E+  + +K+ R  K+   
Sbjct: 438 QK-------------EKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMR-- 482

Query: 383 RENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNKRQSKSTASFEELCSEYRK 442
            + D +   + K+      M +   +  E++++ +E + R + Q K     E++  E + 
Sbjct: 483 EQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREEKKT 542

Query: 443 SRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQEERARAKAKREAAKEICSEFRDQ 502
             +  + +   E                       ++EER R + K+   +E      + 
Sbjct: 543 QEQEKKTWDQEEK---------------------MREEERMREREKKMREEE------EM 575

Query: 503 VRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFKL-EEEEKKNDKEEKGKVEAEKVKRE 561
           +R        +   +R  + KM   +  M     K+ E+EEK  ++EE+ K++ ++    
Sbjct: 576 MREQEEKMQEQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMW 635

Query: 562 AVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTCSMCEAFFQQEAKEKERAEPRA 621
             +E   E    +         + + +   + K+ G    M E   + + +E++  E   
Sbjct: 636 EQEEKMQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEE 695

Query: 622 KVKREAEKETCDEFRRLLQNGKLFCTRE 649
           K++ + EK    E +   Q  K++   E
Sbjct: 696 KMRGQEEKMWGQEEKMWGQEEKMWGQEE 723



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 88/458 (19%), Positives = 173/458 (37%), Gaps = 62/458 (13%)

Query: 469 TCSMCEAFFQQEERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNK 528
           T ++ E  ++QEE  R + K+             +R       R+   +R  +GKM   +
Sbjct: 229 TNTLQEEMWRQEEELREQEKK-------------IRKQEEKMWRQEERLREQEGKMREQE 275

Query: 529 CAMCASVFKLEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPI 588
             M     +L E+EK+  ++EK   E +K++ +  Q    E + + +  ++   RE +  
Sbjct: 276 EKMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKM---REQE-- 330

Query: 589 EGLDGKIHGNTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTR 648
                          E  ++QE    ER   + K  RE E++  D+  R+ +  +    R
Sbjct: 331 ---------------EKMWRQE----ERLWEQEKQMREQEQKMRDQEERMWEQDERL--R 369

Query: 649 ENDPVRGPDGKTHGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECA 708
           E +       K    +  M +    +E E++ R+EEE  R               Q+E  
Sbjct: 370 EKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEE-K 428

Query: 709 EYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSE 768
           E+++Q    +     E + +++ + K +           E +   + E           E
Sbjct: 429 EWQQQRLPEQKEKLWEQEKMQEQEEKIWEQ---------EEKIRDQEEMWGQEKKMWRQE 479

Query: 769 SGKDTCDEFRSQMKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDED 828
             ++  D+   Q +       R+ +       +    +    +EK ER   +KK  + E+
Sbjct: 480 KMREQEDQMWEQEEK-----MRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEE 534

Query: 829 RSNTGERSNTGERSN-DKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQS 887
           +    +++   E+   D+E+  RE   M+   K +   E   +R    KM   +  M   
Sbjct: 535 KMREEKKTQEQEKKTWDQEEKMREEERMREREKKM-REEEEMMREQEEKMQEQEEKM--- 590

Query: 888 IFDREANERKKKDEEKSSSKPSNNAKDQCRQVQNEAED 925
              RE  E+  + EEK   +     + + +  + E ED
Sbjct: 591 ---REQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEED 625


>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           2 [Homo sapiens]
          Length = 782

 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 80/392 (20%), Positives = 157/392 (40%), Gaps = 56/392 (14%)

Query: 410 EEEEKKKKEGKSRNKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNT 469
           E++ +K++E K+  KR   S     +  S      ++ R+  T  N P +  D       
Sbjct: 19  EKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRRED------- 71

Query: 470 CSMCEAFFQQEERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKC 529
            SM +   + +  A    ++ + KE     +D+ R       R H       GK H    
Sbjct: 72  -SMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEK----RRHRSHSAEGGK-HA--- 122

Query: 530 AMCASVFKLEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIE 589
                  +++E+E+++++ ++ + E +K +RE  ++   E        R    RE D +E
Sbjct: 123 -------RVKEKEREHERRKRHREEQDKARREWERQKRREM------AREHSRRERDRLE 169

Query: 590 GLDGKIHGNTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQ--NGKLFCT 647
            L+ K         +   Q+E KE+ER     + +REA +E     R + +  + K+  +
Sbjct: 170 QLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKAS 229

Query: 648 R-ENDPVRGP-------DGKTHGNKCAMCKAVFQKENEER------KRKEEEDQRNAAGH 693
                P R P       DG+         K V +++ EER      +   + +++ ++  
Sbjct: 230 HWSRSPPRPPRERFELGDGR---------KPVKEEKMEERDLLSDLQDISDSERKTSSAE 280

Query: 694 GSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAER 753
            SS   G  +++E  E  E+ + G  S + ES+   + + +      +  +   E+ AE 
Sbjct: 281 SSSAESGSGSEEEEEEEEEEEEEG--STSEESEEEEEEEEEEEEETGSNSEEASEQSAEE 338

Query: 754 KNEYSRSRSNGTGSESGKDTCDEFRSQMKNGK 785
            +E   S      +E+      E R    +G+
Sbjct: 339 VSEEEMSEDEERENENHLLVVPESRFDRDSGE 370



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 78/416 (18%), Positives = 150/416 (36%), Gaps = 86/416 (20%)

Query: 538 LEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDG---- 593
           L+E++++ ++EEK +++  K   +   +  S     +R+ R+  T  N P    D     
Sbjct: 17  LQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDR 76

Query: 594 -------------------KIHG-----------NTCSMCEAFFQQEAKEKERAEPRAKV 623
                              K+H            +     E       KEKER   R K 
Sbjct: 77  GEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKR 136

Query: 624 KREAEKETCDEFRRLLQN--GKLFCTRENDPVRGPDGKTHGNKCAMCKAVFQKENEERKR 681
            RE + +   E+ R  +    +    RE D +   + K    +    +   Q+E +ER+R
Sbjct: 137 HREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERER 196

Query: 682 KEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVRD---ADGKSYNN 738
           + EE ++               +++   Y +++K    S +    P       DG+    
Sbjct: 197 RAEERRKEREARREVSAHHRTMRED---YSDKVKASHWSRSPPRPPRERFELGDGRKPVK 253

Query: 739 QCTMCKAKLEREAERKNEYSRSRSNGTGS--ESGKDTCDEFRSQMKNGKLICTRESDPVR 796
           +  M +  L  + +  ++  R  S+   S  ESG  + +E              E +   
Sbjct: 254 EEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEE-------------EEEEEEE 300

Query: 797 GPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGERSNDKEDLCREFRSMQ 856
             +G T         E+ E E  E++++E+E  SN+ E S        +E++  +     
Sbjct: 301 EEEGST--------SEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEEREN 352

Query: 857 RNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKDEEKSSSKPSNNA 912
            N  L+                     + +S FDR++ E ++ +EE     P ++A
Sbjct: 353 ENHLLV---------------------VPESRFDRDSGESEEAEEEVGEGTPQSSA 387



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 70/373 (18%), Positives = 138/373 (36%), Gaps = 45/373 (12%)

Query: 609 QEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKL-----FCTRENDPVRGPDG---KT 660
           QE K ++  E +A++KR    +  D  R  L+ G+L       T  N P R  D    + 
Sbjct: 18  QEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHRMEITIRNSPYRREDSMEDRG 77

Query: 661 HGNKCAMCKAVFQKENEE----RKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKN 716
             +     K   Q   +E    RK ++ +++R    H + GG     +++  E+  + ++
Sbjct: 78  EEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKRRHRSHSAEGGKHARVKEKEREHERRKRH 137

Query: 717 GRLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDE 776
                  E D  R    +    +  M +    RE +R  +  R R         ++   E
Sbjct: 138 -----REEQDKARREWERQKRRE--MAREHSRRERDRLEQLERKRER---ERKMREQQKE 187

Query: 777 FRSQMKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAA----EKKKKEDEDRSNT 832
            R Q +  +    R  +     +   H    TM ++  ++  A        +   +R   
Sbjct: 188 QREQKERERRAEERRKEREARREVSAHHR--TMREDYSDKVKASHWSRSPPRPPRERFEL 245

Query: 833 GE-RSNTGERSNDKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDR 891
           G+ R    E   ++ DL  + + +  + +   + E++      G              + 
Sbjct: 246 GDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGS-------------EE 292

Query: 892 EANERKKKDEEKSSSKPSNNAKDQCRQVQNEAEDAKFRQPGRSLASVARMSTDECSEFRN 951
           E  E ++++EE S+S+ S   ++   + + E E+        S  S   +S +E SE   
Sbjct: 293 EEEEEEEEEEEGSTSEESEEEEE---EEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEE 349

Query: 952 YIRNNELICPREN 964
               N L+   E+
Sbjct: 350 RENENHLLVVPES 362


>gi|68299793 serine protease inhibitor, Kazal type 6 [Homo sapiens]
          Length = 80

 Score = 50.8 bits (120), Expect = 7e-06
 Identities = 22/40 (55%), Positives = 30/40 (75%), Gaps = 4/40 (10%)

Query: 632 CDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCAMCKAV 671
           C EF    Q+ K++CTRE++P  G DG+T+GNKCA CKA+
Sbjct: 30  CGEF----QDPKVYCTRESNPHCGSDGQTYGNKCAFCKAI 65



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 23/48 (47%), Positives = 30/48 (62%), Gaps = 4/48 (8%)

Query: 764 GTGSESGKDTCDEFRSQMKNGKLICTRESDPVRGPDGKTHGNKCTMCK 811
           G  S+ G+  C EF+      K+ CTRES+P  G DG+T+GNKC  CK
Sbjct: 20  GVFSQGGQVDCGEFQDP----KVYCTRESNPHCGSDGQTYGNKCAFCK 63



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 20/58 (34%), Positives = 32/58 (55%), Gaps = 4/58 (6%)

Query: 94  ELNCDDFKKGERDGDFICPDYYEAVCGTDGKTYDNRCALCAENAKTGSQIGVKSEGEC 151
           +++C +F+    D    C       CG+DG+TY N+CA C    K+G +I +K  G+C
Sbjct: 27  QVDCGEFQ----DPKVYCTRESNPHCGSDGQTYGNKCAFCKAIVKSGGKISLKHPGKC 80



 Score = 45.1 bits (105), Expect = 4e-04
 Identities = 20/42 (47%), Positives = 26/42 (61%), Gaps = 4/42 (9%)

Query: 496 CSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFK 537
           C EF+D      + CTRE NP  G DG+ +GNKCA C ++ K
Sbjct: 30  CGEFQDP----KVYCTRESNPHCGSDGQTYGNKCAFCKAIVK 67



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 17/36 (47%), Positives = 26/36 (72%)

Query: 231 QVRNGRLFCTRESDPVRGPDGRMHGNKCALCAEIFK 266
           + ++ +++CTRES+P  G DG+ +GNKCA C  I K
Sbjct: 32  EFQDPKVYCTRESNPHCGSDGQTYGNKCAFCKAIVK 67



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 16/29 (55%), Positives = 23/29 (79%)

Query: 169 RDGRLGCTRENDPVLGPDGKTHGNKCAMC 197
           +D ++ CTRE++P  G DG+T+GNKCA C
Sbjct: 34  QDPKVYCTRESNPHCGSDGQTYGNKCAFC 62



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 17/42 (40%), Positives = 28/42 (66%), Gaps = 4/42 (9%)

Query: 704 QDECAEYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKA 745
           Q +C E+++     ++ CTRES+P   +DG++Y N+C  CKA
Sbjct: 27  QVDCGEFQDP----KVYCTRESNPHCGSDGQTYGNKCAFCKA 64



 Score = 39.7 bits (91), Expect = 0.016
 Identities = 18/54 (33%), Positives = 31/54 (57%), Gaps = 4/54 (7%)

Query: 367 CSEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGK 420
           C E++    + K+ CTRE++P  G DG+ +GN C+ C+   ++  +   K  GK
Sbjct: 30  CGEFQ----DPKVYCTRESNPHCGSDGQTYGNKCAFCKAIVKSGGKISLKHPGK 79



 Score = 38.9 bits (89), Expect = 0.027
 Identities = 15/39 (38%), Positives = 27/39 (69%), Gaps = 4/39 (10%)

Query: 437 CSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEA 475
           C E++    + +++CTRE++P  G DG+ +GN C+ C+A
Sbjct: 30  CGEFQ----DPKVYCTRESNPHCGSDGQTYGNKCAFCKA 64



 Score = 38.5 bits (88), Expect = 0.035
 Identities = 16/41 (39%), Positives = 27/41 (65%), Gaps = 4/41 (9%)

Query: 945 ECSEFRNYIRNNELICPRENDPVHGADGKFYTNKCYMCRAV 985
           +C EF++     ++ C RE++P  G+DG+ Y NKC  C+A+
Sbjct: 29  DCGEFQD----PKVYCTRESNPHCGSDGQTYGNKCAFCKAI 65



 Score = 38.5 bits (88), Expect = 0.035
 Identities = 15/41 (36%), Positives = 20/41 (48%)

Query: 1036 CPKDLKPVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKC 1076
            C ++  P CG DGQTY N C  C   +       ++  GKC
Sbjct: 40   CTRESNPHCGSDGQTYGNKCAFCKAIVKSGGKISLKHPGKC 80



 Score = 38.1 bits (87), Expect = 0.046
 Identities = 24/75 (32%), Positives = 36/75 (48%), Gaps = 4/75 (5%)

Query: 1  MKIATVSVLLPLALCLIQDAASKNEDQEMCHEFQAFMKNGKLFCPQDKKFFQSLDGIMFI 60
          MK++ + +LL LAL            Q  C EFQ    + K++C ++       DG  + 
Sbjct: 1  MKLSGMFLLLSLALFCFLTGVFSQGGQVDCGEFQ----DPKVYCTRESNPHCGSDGQTYG 56

Query: 61 NKCATCKMILEKEAK 75
          NKCA CK I++   K
Sbjct: 57 NKCAFCKAIVKSGGK 71



 Score = 38.1 bits (87), Expect = 0.046
 Identities = 21/51 (41%), Positives = 30/51 (58%), Gaps = 4/51 (7%)

Query: 838 TGERSNDKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSI 888
           TG  S   +  C EF+    + K+ CTRE+NP  G  G+ + NKCA C++I
Sbjct: 19  TGVFSQGGQVDCGEFQ----DPKVYCTRESNPHCGSDGQTYGNKCAFCKAI 65



 Score = 38.1 bits (87), Expect = 0.046
 Identities = 15/39 (38%), Positives = 26/39 (66%), Gaps = 4/39 (10%)

Query: 297 CSQYQNQAKNGILFCTRENDPIRGPDGKMHGNLCSMCQA 335
           C ++Q+      ++CTRE++P  G DG+ +GN C+ C+A
Sbjct: 30  CGEFQDPK----VYCTRESNPHCGSDGQTYGNKCAFCKA 64



 Score = 37.0 bits (84), Expect = 0.10
 Identities = 16/46 (34%), Positives = 28/46 (60%), Gaps = 4/46 (8%)

Query: 567 CSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTCSMCEAFFQQEAK 612
           C E++    + ++ CTRE++P  G DG+ +GN C+ C+A  +   K
Sbjct: 30  CGEFQ----DPKVYCTRESNPHCGSDGQTYGNKCAFCKAIVKSGGK 71


>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 668

 Score = 50.4 bits (119), Expect = 9e-06
 Identities = 71/376 (18%), Positives = 151/376 (40%), Gaps = 40/376 (10%)

Query: 202 LKEAENAKREGETRIRRNAEKDFCKEYEKQVRNGRLFCTRESDPVRGPDGRMHGNKCALC 261
           ++E E   RE E ++RR  E  + KE EK  R   +   +E         +M   +  + 
Sbjct: 323 IREQEEKIREQEEKMRRQEEMMWEKE-EKMRRQEEMMWEKEE--------KMRRLEEMMW 373

Query: 262 AEIFKQRFSEENSKTDQNLGKAEEKTKVKREIVKLCSQYQNQAKNGILFCTRENDPIRGP 321
            +  K R  EE     + + + EEK + + +I +   + + +AK       R+ + IR  
Sbjct: 374 EKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAK-----MWRQEEKIREQ 428

Query: 322 DGKMHGNLCSMCQAYFQAENEEKKKAEARARNK----RESGKATSYAELCSEYRKLVRNG 377
           + K+      M +   +   +EK + E + + +    R+  K     E+  +  K+    
Sbjct: 429 EEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQE 488

Query: 378 KLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNKRQSKSTASFEELC 437
           K+   ++ + +   + K+H              ++E+K +E + +  RQ +     EE  
Sbjct: 489 KIR--KQEEKVWRQEEKMH--------------DQEEKIREQEEKMWRQEEKIREQEEKI 532

Query: 438 SEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQEERARAKAKR-EAAKEIC 496
            E  +  +        + + +   + KM        E   +QEE+ R + ++    KE  
Sbjct: 533 REQEEKIREQEEMMQEQEEKMGEQEEKMQEQ-----EKMRRQEEKIREQEEKIREQKEKI 587

Query: 497 SEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFKLEEEEKKNDKEEKGKVEAE 556
            E  +++         +   ++  + KM   +  MC    K++E+E+K  ++E+   E E
Sbjct: 588 REQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQE 647

Query: 557 KVKREAVQELCSEYRH 572
              R+  +++     H
Sbjct: 648 VRLRQQEEKMQEHQEH 663



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 64/312 (20%), Positives = 129/312 (41%), Gaps = 42/312 (13%)

Query: 340 ENEEKKKAEARARNKRESGKATSYAELCSEYRKLVRNGKLACTRENDPIQGPDGKVHGNT 399
           E EEK   + + R + E  K     ++  + ++  +  K+   R+ + I+  + K+    
Sbjct: 381 ELEEKMHEQEKIREQEE--KRQEEEKIREQEKRQEQEAKM--WRQEEKIREQEEKIREQE 436

Query: 400 CSMCEVFFQAEEEEKKKKEGKSRNKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQ 459
             M     +  E+EK ++E     KRQ +     EE+  +  K R+   ++  +E     
Sbjct: 437 KKMWRQEEKIHEQEKIREE----EKRQEQ-----EEMWRQEEKIREQEEIWRQKE----- 482

Query: 460 GPDGKMHGNTCSMCEAFFQQEERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRG 519
               KMH           +QE+  + + K    +E   +  +++R       R+   +R 
Sbjct: 483 ----KMH-----------EQEKIRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIRE 527

Query: 520 PDGKMHGNKCAMCASVFKLEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRL 579
            + K+   +  +      ++E+E+K  ++E+   E EK++R+  +E   E    +R  + 
Sbjct: 528 QEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQ--EEKIREQEEKIREQKE 585

Query: 580 PCTRENDPIEGLDGKIHGNTCSMC---EAFFQQEAK----EKERAEPRAKVKREAEKETC 632
               + + I   + KI      M    E  ++QE K    E++  E   K++R+ EK   
Sbjct: 586 KIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWE 645

Query: 633 DEFRRLLQNGKL 644
            E R   Q  K+
Sbjct: 646 QEVRLRQQEEKM 657



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 59/326 (18%), Positives = 140/326 (42%), Gaps = 21/326 (6%)

Query: 539 EEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGN 598
           E+EEK  ++EEK + + EK++R+  +E+  E    +R        + + +  L+  +   
Sbjct: 318 EQEEKIREQEEKIREQEEKMRRQ--EEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEK 375

Query: 599 TCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDG 658
              + E   +   +EK R +   + KR+ E++  ++ +R  Q  K++  R+ + +R  + 
Sbjct: 376 EEKIRELEEKMHEQEKIREQ---EEKRQEEEKIREQEKRQEQEAKMW--RQEEKIREQEE 430

Query: 659 KTHGNKCAMCKA-----VFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQ 713
           K    +  M +        +K  EE KR+E+E+                 +++  E +E+
Sbjct: 431 KIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHE-QEK 489

Query: 714 MKNGRLSCTRESDPVRDADGKSYNNQCTMCKAK---LEREAERKNEYSRSRSNGTGSESG 770
           ++       R+ + + D + K    +  M + +    E+E + + +  + R      +  
Sbjct: 490 IRKQEEKVWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQ 549

Query: 771 KDTCDEFRSQMKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRS 830
           ++   E   +M+  + +  R+ + +R  + K    K  + +++ +    E+K +E E+  
Sbjct: 550 EEKMGEQEEKMQEQEKM-RRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMM 608

Query: 831 NTGERSNTGERSNDKEDLCREFRSMQ 856
              E     +    +E +C +   MQ
Sbjct: 609 QEQEE----KMWEQEEKMCEQEEKMQ 630


>gi|13540523 nucleosomal binding protein 1 [Homo sapiens]
          Length = 282

 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 48/167 (28%), Positives = 75/167 (44%), Gaps = 21/167 (12%)

Query: 675 ENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYR-EQMKNGRLS---CTRESDPVRD 730
           +NEE  +KE+E+ +N       G  G   +DE  E   ++ KNG         + D  + 
Sbjct: 124 KNEEEDQKEDEEDQNE----EKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKG 179

Query: 731 ADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKLICTR 790
            DGK  N +    K + E+E E + E    + N  G E G           K GK +  +
Sbjct: 180 EDGKG-NGEDGKEKGEDEKEEEDRKETGDGKENEDGKEKG---------DKKEGKDVKVK 229

Query: 791 ESDPVRGPDGKTH--GNKCTMCKEKLEREAAEKKKKEDEDRSNTGER 835
           E +  R  DGK    GN+    KEK + +  E+ K+EDE + + G++
Sbjct: 230 EDEKER-EDGKEDEGGNEEEAGKEKEDLKEEEEGKEEDEIKEDDGKK 275



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 74/301 (24%), Positives = 116/301 (38%), Gaps = 65/301 (21%)

Query: 452 TRENDPIQGPDGKMHGNTCSMCEAFFQQEERARAKAKREAAKEICSEFRDQVRNGTLICT 511
           T E  P +    +       M E       +A A+ K+EA  E   ++ +  +NG    T
Sbjct: 31  TPEVKPKRTSSSRKMKTKSDMMEENIDTSAQAVAETKQEAVVE--EDYNENAKNGEAKIT 88

Query: 512 R----EHNPVRGPDGKMH------GNKCAMCASVFKLEEEEKKNDKEEKGKVEAEKVKRE 561
                E   V   +  +       G K    A+  K EEE++K D+E++ + + E  K E
Sbjct: 89  EAPASEKEIVEVKEENIEDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGK-E 147

Query: 562 AVQELCSEYRHYVRNGR---LPCTRENDPIEGLDGKIHGNTCSMCEAFFQQEAKEKERAE 618
              E   E     +NG         + D  +G DGK +G           ++ KEK   E
Sbjct: 148 DKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKGNG-----------EDGKEKGEDE 196

Query: 619 PRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCAMCKAVFQKENEE 678
                + E  KET D              +EN+     DGK  G+K         KE ++
Sbjct: 197 K----EEEDRKETGD-------------GKENE-----DGKEKGDK---------KEGKD 225

Query: 679 RKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVRDADGKSYNN 738
            K KE+E +R     G    GG   ++E  + +E +K       +E D +++ DGK    
Sbjct: 226 VKVKEDEKERE---DGKEDEGG--NEEEAGKEKEDLKEEEEG--KEEDEIKEDDGKKEEP 278

Query: 739 Q 739
           Q
Sbjct: 279 Q 279



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 47/206 (22%), Positives = 79/206 (38%), Gaps = 21/206 (10%)

Query: 673 QKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAE--YREQMKNGRLSCTR------- 723
           ++ +  RK K + D        S+       Q+   E  Y E  KNG    T        
Sbjct: 37  KRTSSSRKMKTKSDMMEENIDTSAQAVAETKQEAVVEEDYNENAKNGEAKITEAPASEKE 96

Query: 724 ----ESDPVRDADGKS-YNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTC-DEF 777
               + + + DA  K     +    + K E E ++++E  ++   G   +  KD   +E 
Sbjct: 97  IVEVKEENIEDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEED 156

Query: 778 RSQMKNGKLI---CTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGE 834
             + KNG         + D  +G DGK +G      KEK E E  E+ +KE  D     +
Sbjct: 157 GKEDKNGNEKGEDAKEKEDGKKGEDGKGNGEDG---KEKGEDEKEEEDRKETGDGKENED 213

Query: 835 RSNTGERSNDKEDLCREFRSMQRNGK 860
               G++   K+   +E    + +GK
Sbjct: 214 GKEKGDKKEGKDVKVKEDEKEREDGK 239



 Score = 32.7 bits (73), Expect = 1.9
 Identities = 40/161 (24%), Positives = 63/161 (39%), Gaps = 32/161 (19%)

Query: 410 EEEEKKKKEGKSRNKRQSKSTASFEELCSEYRKSRKNGR---LFCTRENDPIQGPDGKMH 466
           EEE++K+ E     ++        +E   E  K  KNG         + D  +G DGK +
Sbjct: 126 EEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKGN 185

Query: 467 GNTCSMCEAFFQQEERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHG 526
           G             E  + K + E  +E   E  D   N               DGK  G
Sbjct: 186 G-------------EDGKEKGEDEKEEEDRKETGDGKEN--------------EDGKEKG 218

Query: 527 NKCAMCASVFKLEEEEKKNDKEEKG--KVEAEKVKREAVQE 565
           +K        K +E+E+++ KE++G  + EA K K +  +E
Sbjct: 219 DKKEGKDVKVKEDEKEREDGKEDEGGNEEEAGKEKEDLKEE 259



 Score = 30.4 bits (67), Expect = 9.6
 Identities = 27/113 (23%), Positives = 48/113 (42%), Gaps = 9/113 (7%)

Query: 815 EREAAEKKKKEDEDRSNTGERSNTGERSNDKEDLCREFRSMQRNGKLICTRENNPVRGPY 874
           E+E  E K++  ED +  G     GE+   KE +  E ++ + + K     + N  +G  
Sbjct: 94  EKEIVEVKEENIEDATEKG-----GEK---KEAVAAEVKNEEEDQKED-EEDQNEEKGEA 144

Query: 875 GKMHINKCAMCQSIFDREANERKKKDEEKSSSKPSNNAKDQCRQVQNEAEDAK 927
           GK   ++        D+  NE+ +  +EK   K   + K      + + ED K
Sbjct: 145 GKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDGKKGEDGKGNGEDGKEKGEDEK 197


>gi|29568105 transmembrane protein with EGF-like and two
            follistatin-like domains 1 [Homo sapiens]
          Length = 380

 Score = 48.9 bits (115), Expect = 3e-05
 Identities = 38/137 (27%), Positives = 56/137 (40%), Gaps = 18/137 (13%)

Query: 960  CPRENDPVHGADGKFYTNKCYMCRAVF-----LTEALERAKLQEKPSHVRASQEEDSPDS 1014
            C     PV G++G  Y N+C++ RA       +T         +  S     +EE S   
Sbjct: 103  CHTNYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAE 162

Query: 1015 FSSLDSEM--CKDYRV-----LPRIGYLCPKD-----LKPVCGDDGQTYNNPCMLCHENL 1062
                 S+   CK Y+         +G +C  D       PVC  DG +YNNPC +   + 
Sbjct: 163  VHRKHSKCGPCK-YKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASC 221

Query: 1063 IRQTNTHIRSTGKCEES 1079
            I+Q    IR  G C ++
Sbjct: 222  IKQEQIDIRHLGHCTDT 238



 Score = 40.4 bits (93), Expect = 0.009
 Identities = 39/143 (27%), Positives = 51/143 (35%), Gaps = 41/143 (28%)

Query: 104 ERDGD-------FICPDYYEAVCGTDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSN- 155
           + DGD       F C   Y  VCG++G TY N C L     K   +I V + G C S N 
Sbjct: 89  KEDGDGLKCACQFQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNG 148

Query: 156 -------PEQDVCSAFRPFVRDG-------------RLGCTREND-------PVLGPDGK 188
                   E       R   + G              +GC    D       PV   DG 
Sbjct: 149 SGSGEGEEEGSGAEVHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGS 208

Query: 189 THGNKCAMCAELFLKEAENAKRE 211
           ++ N C      F++EA   K+E
Sbjct: 209 SYNNPC------FVREASCIKQE 225



 Score = 36.6 bits (83), Expect = 0.13
 Identities = 31/124 (25%), Positives = 51/124 (41%), Gaps = 17/124 (13%)

Query: 646 CTRENDPVRGPDGKTHGNKCAMCKAVFQKENEER---KRKEEEDQRNAAGHGSSGGGGGN 702
           C     PV G +G T+ N+C + +A  + + E     +     D  + +G G   G G  
Sbjct: 103 CHTNYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGSGEGEEEGSGAE 162

Query: 703 TQ---DEC------AEYREQMKNGRLSCTRES-----DPVRDADGKSYNNQCTMCKAKLE 748
                 +C      AE  E  +N    C  +      +PV  +DG SYNN C + +A   
Sbjct: 163 VHRKHSKCGPCKYKAECDEDAENVGCVCNIDCSGYSFNPVCASDGSSYNNPCFVREASCI 222

Query: 749 REAE 752
           ++ +
Sbjct: 223 KQEQ 226



 Score = 33.5 bits (75), Expect = 1.1
 Identities = 15/51 (29%), Positives = 22/51 (43%)

Query: 1034 YLCPKDLKPVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKCEESSTPGT 1084
            + C  +  PVCG +G TY N C L       Q    + + G C   +  G+
Sbjct: 101  FQCHTNYIPVCGSNGDTYQNECFLRRAACKHQKEITVIARGPCYSDNGSGS 151



 Score = 32.3 bits (72), Expect = 2.5
 Identities = 18/66 (27%), Positives = 32/66 (48%), Gaps = 6/66 (9%)

Query: 111 CPDY-YEAVCGTDGKTYDNRCALCAENAKTGSQIGVKSEGECKSSNP-----EQDVCSAF 164
           C  Y +  VC +DG +Y+N C +   +     QI ++  G C  ++      ++D    +
Sbjct: 194 CSGYSFNPVCASDGSSYNNPCFVREASCIKQEQIDIRHLGHCTDTDDTSLLGKKDDGLQY 253

Query: 165 RPFVRD 170
           RP V+D
Sbjct: 254 RPDVKD 259


>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
           [Homo sapiens]
          Length = 899

 Score = 48.1 bits (113), Expect = 4e-05
 Identities = 111/542 (20%), Positives = 206/542 (38%), Gaps = 56/542 (10%)

Query: 341 NEEKKKAEARARNK---RESGKATSYAELCSEYRKLVRNGKLA-----------CTREND 386
           NEE KK  A  + K    ES K+     +    RKL R   L              R+ +
Sbjct: 220 NEELKKKNAELQEKLPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEE 279

Query: 387 PIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNKRQSKSTASFEELCSEYRKSRKN 446
            ++  + K+      M     +  E+E K +E + +  RQ K     E+   E  K  + 
Sbjct: 280 ELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELRE 339

Query: 447 GRLFCTRENDPIQGPDGKMHGNTCSMCEA---FFQQEERARAKAKREAAKEICSEFRDQV 503
            +    +E + +Q  + KM      M E     ++QEER   + K+   +E   + RDQ 
Sbjct: 340 QKELREQE-EQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQE--QKMRDQE 396

Query: 504 RNGTLICTREHNPVRGPDGKMHGNKCAMCASVFKLEEEEKKNDKEEKGKVEAEKVKREAV 563
                    +   +R  + +M   +  M   V K+ EE+K  ++E+K + + EK++ E  
Sbjct: 397 ER----MWEQDERLREKEERMREQE-KMWEQVEKMREEKKMQEQEKKTRDQEEKMQEE-- 449

Query: 564 QELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTCSMCEAFFQQEAKEKERAEPRAKV 623
                     +R        E + +   + K+     +M E   Q+E + +++  P  K 
Sbjct: 450 --------ERIREREKKMREEEETMREQEEKMQKQEENMWE---QEEKEWQQQRLPEQKE 498

Query: 624 KR-EAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCAMCKAVFQKENEERKRK 682
           K  E EK    E +   Q  K+   R+ + + G + K    +    +     E EE+ R 
Sbjct: 499 KLWEQEKMQEQEEKIWEQEEKI---RDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRD 555

Query: 683 EEE---DQRNAAGHGSSGGGGGN-TQDECAEYREQMKNGRLSCTRESDPVRDADGKSYNN 738
           +E+   DQ       +         Q+E     E+M+        E + +R+ + K    
Sbjct: 556 QEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQ 615

Query: 739 QCTMCKAKLEREAER--KNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKLICTRESDPVR 796
           +      K++ + E+  + E           E  +   ++     +  +L    + + + 
Sbjct: 616 E-----EKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRL--PEQKEKLW 668

Query: 797 GPDGKTHGNKCTMCKEKL-EREAAEKKKKEDEDRSNTGERSNTGERSNDKEDLCREFRSM 855
             +      K    +EK+ E+E  EKK +E E ++   E+    E   ++E   RE   M
Sbjct: 669 EHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEM 728

Query: 856 QR 857
            R
Sbjct: 729 MR 730



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 95/499 (19%), Positives = 193/499 (38%), Gaps = 61/499 (12%)

Query: 177 RENDPVLGPDGKTHGNKCAMCAELFLKEAENAKREGETRIRRNAEKDFCKEYEKQVRNGR 236
           RE   +   + KT   +  M  E  ++E E   RE E  +R   EK      +KQ  N  
Sbjct: 427 REEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEETMREQEEK-----MQKQEENMW 481

Query: 237 LFCTRESDPVRGPDGRMHGNKCALCAEIFKQRFSEENSKTDQNLGKAEEKTKVKREIVKL 296
               +E    R P+ +          ++++Q   E+  + ++ + + EEK + + E+   
Sbjct: 482 EQEEKEWQQQRLPEQK---------EKLWEQ---EKMQEQEEKIWEQEEKIRDQEEMWGQ 529

Query: 297 CSQYQNQAKNGILFCTRENDPIRGPDGKMHGNLCSMCQAYFQAEN---EEKKKAEARARN 353
             +   Q K        + D +   + KM      M     + E    E++KK   +   
Sbjct: 530 EKKMWRQEK-----MREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEK 584

Query: 354 KRESGKATSYAELCSEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEE 413
            RE  +     +   E  +++R  +     + + +Q  + K+      M E   +  E+E
Sbjct: 585 MREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQE 644

Query: 414 KKKKEGKSRNKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMC 473
           +K  E + +   Q +     E+L  E+ K ++  ++   +E +       KM   T    
Sbjct: 645 EKMWEQEEKMWEQQRLPEQKEKLW-EHEKMQEQEKM---QEQEEKIWEQEKMEKKTQEQE 700

Query: 474 EAFFQQEERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCA 533
           +  + QE+    ++ RE  K++  E  + +R        +   ++  + +M   +  M  
Sbjct: 701 KKTWDQEKMREEESMREREKKMREE-EEMMREQEEKMQEQEEKMQEQEEEMWEQEEKMWE 759

Query: 534 SVFKL--------------------------EEEEKKNDKEEKGKVEAEKVKREAVQELC 567
              K+                          E+EEK  D+EEK + + EK++ +  +   
Sbjct: 760 QEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRG 819

Query: 568 SEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTCSMCEAFFQQEAKEKERAEPRAKVKREA 627
            E + + +  ++    + + + G + K+ G    M E    QE K +E+ E   K++ + 
Sbjct: 820 QEEKMWGQEEKM--WGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEE---KMRGQE 874

Query: 628 EKETCDEFRRLLQNGKLFC 646
           EK    E +   Q  K++C
Sbjct: 875 EKMREQEEKMRGQEEKIYC 893


>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
          Length = 494

 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 67/359 (18%), Positives = 129/359 (35%), Gaps = 33/359 (9%)

Query: 588 IEGLDG-KIHGNTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFC 646
           +E LDG +++G    + E    +    + R+  R++    +   +    +   ++G    
Sbjct: 157 LEKLDGTEVNGRKIRLVE---DKPGSRRRRSYSRSRSHSRSRSRSRHSRKSRSRSGSSKS 213

Query: 647 TRENDPVRGPDGKTHGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDE 706
           +      R   G    +K         +  +E+ R   +++  +  H S+G     ++D+
Sbjct: 214 SHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEKSRSRSH-SAGKSRSKSKDQ 272

Query: 707 CAEYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKLE--------REAERKNEYS 758
             E  +   N  +   +   P R        ++    + + E        R  E+    S
Sbjct: 273 AEE--KIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQS 330

Query: 759 RSRSNGTGSESGKDTCDEFRSQMKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREA 818
           RSRS   G    +          + G+     ES        K+  ++    K   +  +
Sbjct: 331 RSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKRDSKAGS 390

Query: 819 AEKKKKEDEDRSNTGERSNTGERSNDKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMH 878
           ++KKKKED DRS    +S +  RS  KE    +  S QR G           RG      
Sbjct: 391 SKKKKKEDTDRS----QSRSPSRSVSKEREHAKSESSQREG-----------RGESENAG 435

Query: 879 INKCAMCQSIFDREANER---KKKDEEKSSSKPSNNAKDQCRQVQNEAEDAKFRQPGRS 934
            N+    +S  + ++      + +   KS+SK  + +K + R        ++ R   RS
Sbjct: 436 TNQETRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSASRSPSRSRSRSHSRS 494



 Score = 31.2 bits (69), Expect = 5.6
 Identities = 50/252 (19%), Positives = 101/252 (40%), Gaps = 38/252 (15%)

Query: 270 SEENSKTDQNLGKAEEKTKVKREIVKLCSQYQNQAKNGILFCTRENDPIRGPDGKMHGNL 329
           +EE  + + N+GK + ++   R   K  S+ ++Q +       R  +  RG   +     
Sbjct: 273 AEEKIQNNDNVGKPKSRSP-SRHKSKSKSRSRSQER-------RVEEEKRGSVSRGRSQE 324

Query: 330 CSMCQAYFQAENEEKKKAEARARNK---RESGKATSYAELCSEYR---KLVRNGKLACTR 383
            S+ Q+  ++ ++   ++ +R+R+K   +  G+  S  E  S  R   K  R+ K    R
Sbjct: 325 KSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKSERSRKRGSKR 384

Query: 384 ENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNKRQSKSTASFEELCSEYRKS 443
           ++                      +A   +KKKKE   R++ +S S +  +E   E+ KS
Sbjct: 385 DS----------------------KAGSSKKKKKEDTDRSQSRSPSRSVSKE--REHAKS 420

Query: 444 RKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQEERARAKAKREAAKEICSEFRDQV 503
             + R       +     + +    + S  +     E R+R+K+  +      S  R   
Sbjct: 421 ESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRSKSASKTRSRSKSRSRSAS 480

Query: 504 RNGTLICTREHN 515
           R+ +   +R H+
Sbjct: 481 RSPSRSRSRSHS 492


>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
          Length = 780

 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 82/392 (20%), Positives = 154/392 (39%), Gaps = 58/392 (14%)

Query: 410 EEEEKKKKEGKSRNKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNT 469
           E++ +K++E K+  KR   S     +  S      ++  +  T  N P +  D       
Sbjct: 19  EKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRRED------- 71

Query: 470 CSMCEAFFQQEERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKC 529
            SM +   + +  A    ++ + KE     +D+ R       R H+     +G  H    
Sbjct: 72  -SMEDRGEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKC---RHHS--HSAEGGKH---- 121

Query: 530 AMCASVFKLEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIE 589
              A V + E E +K  +EE+ K   E  +R+  +E+  E+            RE D +E
Sbjct: 122 ---ARVKEREHERRKRHREEQDKARREW-ERQKRREMAREHSR----------RERDRLE 167

Query: 590 GLDGKIHGNTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQ--NGKLFCT 647
            L+ K         +   Q+E KE+ER     + +REA +E     R + +  + K+  +
Sbjct: 168 QLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKAS 227

Query: 648 R-ENDPVRGP-------DGKTHGNKCAMCKAVFQKENEER------KRKEEEDQRNAAGH 693
                P R P       DG+         K V +++ EER      +   + +++ ++  
Sbjct: 228 HWSRSPPRPPRERFELGDGR---------KPVKEEKMEERDLLSDLQDISDSERKTSSAE 278

Query: 694 GSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAER 753
            SS   G  +++E  E  E+ + G  S + ES+   + + +      +  +   E+ AE 
Sbjct: 279 SSSAESGSGSEEEEEEEEEEEEEG--STSEESEEEEEEEEEEEEETGSNSEEASEQSAEE 336

Query: 754 KNEYSRSRSNGTGSESGKDTCDEFRSQMKNGK 785
            +E   S      +E+      E R    +G+
Sbjct: 337 VSEEEMSEDEERENENHLLVVPESRFDRDSGE 368



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 74/371 (19%), Positives = 135/371 (36%), Gaps = 43/371 (11%)

Query: 609 QEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKL--FC---TRENDPVRGPDGKTHGN 663
           QE K ++  E +A++KR    +  D  R  L+ G+L   C   T  N P R  D      
Sbjct: 18  QEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDRG 77

Query: 664 KCAMCKAVFQKENEERK-----RKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGR 718
           +     A+   +   RK     RK+E+ +     H  S  GG +     A  +E+    R
Sbjct: 78  EEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKCRHHSHSAEGGKH-----ARVKEREHERR 132

Query: 719 LSCTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFR 778
                E D  R    +    +  M +    RE +R  +  R R         ++   E R
Sbjct: 133 KRHREEQDKARREWERQKRRE--MAREHSRRERDRLEQLERKRER---ERKMREQQKEQR 187

Query: 779 SQMKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAA----EKKKKEDEDRSNTGE 834
            Q +  +    R  +     +   H    TM ++  ++  A        +   +R   G+
Sbjct: 188 EQKERERRAEERRKEREARREVSAHHR--TMREDYSDKVKASHWSRSPPRPPRERFELGD 245

Query: 835 -RSNTGERSNDKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREA 893
            R    E   ++ DL  + + +  + +   + E++      G              + E 
Sbjct: 246 GRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGS-------------EEEE 292

Query: 894 NERKKKDEEKSSSKPSNNAKDQCRQVQNEAEDAKFRQPGRSLASVARMSTDECSEFRNYI 953
            E ++++EE S+S+ S   ++   + + E E+        S  S   +S +E SE     
Sbjct: 293 EEEEEEEEEGSTSEESEEEEE---EEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERE 349

Query: 954 RNNELICPREN 964
             N L+   E+
Sbjct: 350 NENHLLVVPES 360



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 61/311 (19%), Positives = 118/311 (37%), Gaps = 52/311 (16%)

Query: 609 QEAKEKERAEPRAKVKREAEKETCDEFRRLLQN--GKLFCTRENDPVRGPDGKTHGNKCA 666
           + A+ KER   R K  RE + +   E+ R  +    +    RE D +   + K    +  
Sbjct: 120 KHARVKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKM 179

Query: 667 MCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESD 726
             +   Q+E +ER+R+ EE ++               +++   Y +++K    S +    
Sbjct: 180 REQQKEQREQKERERRAEERRKEREARREVSAHHRTMRED---YSDKVKASHWSRSPPRP 236

Query: 727 PVRD---ADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGS--ESGKDTCDEFRSQM 781
           P       DG+    +  M +  L  + +  ++  R  S+   S  ESG  + +E     
Sbjct: 237 PRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEE----- 291

Query: 782 KNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGER 841
                    E +     +G T         E+ E E  E++++E+E  SN+ E S     
Sbjct: 292 --------EEEEEEEEEEGST--------SEESEEEEEEEEEEEEETGSNSEEASEQSAE 335

Query: 842 SNDKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKDE 901
              +E++  +      N  L+                     + +S FDR++ E ++ +E
Sbjct: 336 EVSEEEMSEDEERENENHLLV---------------------VPESRFDRDSGESEEAEE 374

Query: 902 EKSSSKPSNNA 912
           E     P ++A
Sbjct: 375 EVGEGTPQSSA 385


>gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]
          Length = 290

 Score = 47.8 bits (112), Expect = 6e-05
 Identities = 44/188 (23%), Positives = 77/188 (40%), Gaps = 13/188 (6%)

Query: 673 QKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVRDAD 732
           +K + ER+RKE+E  RN             T+ E    RE+ K       R  +  RD D
Sbjct: 96  RKRDRERRRKEKETNRNRDREKQ-------TEIERDREREKQKGRERERDRGRERERDRD 148

Query: 733 GKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKLICTRES 792
            +    + T      +RE E + E  R R      E+ +D     R + ++ +    R++
Sbjct: 149 REKERERQTEKDRDGQRETETERERDREREKQKERETERD-----RDRQRDTEKERERQT 203

Query: 793 DPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGERSNDKEDLCREF 852
           D  R    KT   +      + ERE  +++++   DR    ER    +R  +++   ++ 
Sbjct: 204 DRERDRQRKTQTERQRETDREGERE-TDRRRERQRDRDRGKERDRERDRKEERKKERKKE 262

Query: 853 RSMQRNGK 860
           R  +R  K
Sbjct: 263 RKKERKEK 270



 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 51/234 (21%), Positives = 93/234 (39%), Gaps = 34/234 (14%)

Query: 608 QQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCAM 667
           ++  KE++R   R + +R  EKET +  R   +  ++   RE +  +G + +    +   
Sbjct: 86  EKTEKERDRDRKRDRERRRKEKET-NRNRDREKQTEIERDREREKQKGRERERDRGRERE 144

Query: 668 CKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDP 727
                +KE E +  K+ + QR              T+ E    RE+ K       R+ D 
Sbjct: 145 RDRDREKERERQTEKDRDGQR-------------ETETERERDREREKQKERETERDRDR 191

Query: 728 VRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKLI 787
            RD                 E+E ER+ +  R R   T +E  ++T  E   +    +  
Sbjct: 192 QRDT----------------EKERERQTDRERDRQRKTQTERQRETDREGERETDRRR-- 233

Query: 788 CTRESDPVRGPD-GKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGE 840
             R+ D  RG +  +    K    KE+ +    E+K+K+ E++    ++   GE
Sbjct: 234 -ERQRDRDRGKERDRERDRKEERKKERKKERKKERKEKKKEEKRREDKKRKWGE 286



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 54/262 (20%), Positives = 100/262 (38%), Gaps = 29/262 (11%)

Query: 679 RKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVRDADGKSYNN 738
           R   +E  +    G       G + Q E    RE+ +  R    +     R  + ++  N
Sbjct: 53  RLGSQESPRSWGLGQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRN 112

Query: 739 QCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKLICTRESDPVRGP 798
           +    + ++ER+ ER+ +  R R    G E  +D                 RE +  R  
Sbjct: 113 RDREKQTEIERDREREKQKGRERERDRGRERERDR---------------DREKERERQT 157

Query: 799 DGKTHGNKCTMCKEKLEREAAEKKKKEDE-DRSNTGERSNTGERSNDKEDLCREFRSMQR 857
           +    G + T  + + +RE  ++K++E E DR    +     ER  D+E      R  QR
Sbjct: 158 EKDRDGQRETETERERDREREKQKERETERDRDRQRDTEKERERQTDRE------RDRQR 211

Query: 858 NGKLICTRENNPVRGPYGKMHINKCAMCQSIFDR---EANERKKKDEEKSSSKPSNNAKD 914
             +    RE +      G+   ++    Q   DR      ER +K+E K   K     + 
Sbjct: 212 KTQTERQRETD----REGERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKER 267

Query: 915 QCRQVQNEAEDAKFRQPGRSLA 936
           + ++ + +  + K R+ G  ++
Sbjct: 268 KEKKKEEKRREDKKRKWGEGIS 289


>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           9 [Homo sapiens]
          Length = 771

 Score = 47.4 bits (111), Expect = 8e-05
 Identities = 76/405 (18%), Positives = 148/405 (36%), Gaps = 75/405 (18%)

Query: 538 LEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDG---- 593
           L+E++++ ++EEK +++  K   +   +  S     +R+  +  T  N P    D     
Sbjct: 17  LQEKKRRKEQEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEITIRNSPYRREDSMEDR 76

Query: 594 -------------------KIHGNTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDE 634
                              K+H       +       KEKER   R K  RE + +   E
Sbjct: 77  GEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHARVKEKEREHERRKRHREEQDKARRE 136

Query: 635 FRRLLQN--GKLFCTRENDPVRGPDGKTHGNKCAMCKAVFQKENEERKRKEEEDQRNAAG 692
           + R  +    +    RE D +   + K    +    +   Q+E +ER+R+ EE ++    
Sbjct: 137 WERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREA 196

Query: 693 HGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVRD---ADGKSYNNQCTMCKAKLER 749
                      +++   Y +++K    S +    P       DG+    +  M +  L  
Sbjct: 197 RREVSAHHRTMRED---YSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLS 253

Query: 750 EAERKNEYSRSRSNGTGS--ESGKDTCDEFRSQMKNGKLICTRESDPVRGPDGKTHGNKC 807
           + +  ++  R  S+   S  ESG  + +E              E +     +G T     
Sbjct: 254 DLQDISDSERKTSSAESSSAESGSGSEEE-------------EEEEEEEEEEGST----- 295

Query: 808 TMCKEKLEREAAEKKKKEDEDRSNTGERSNTGERSNDKEDLCREFRSMQRNGKLICTREN 867
               E+ E E  E++++E+E  SN+ E S        +E++  +      N  L+     
Sbjct: 296 ---SEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMSEDEERENENHLLV----- 347

Query: 868 NPVRGPYGKMHINKCAMCQSIFDREANERKKKDEEKSSSKPSNNA 912
                           + +S FDR++ E ++ +EE     P ++A
Sbjct: 348 ----------------VPESRFDRDSGESEEAEEEVGEGTPQSSA 376



 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 55/265 (20%), Positives = 113/265 (42%), Gaps = 33/265 (12%)

Query: 537 KLEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIH 596
           +++E+E+++++ ++ + E +K +RE  ++   E        R    RE D +E L+ K  
Sbjct: 112 RVKEKEREHERRKRHREEQDKARREWERQKRREM------AREHSRRERDRLEQLERKRE 165

Query: 597 GNTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQ--NGKLFCTR-ENDPV 653
                  +   Q+E KE+ER     + +REA +E     R + +  + K+  +     P 
Sbjct: 166 RERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPP 225

Query: 654 RGP-------DGKTHGNKCAMCKAVFQKENEER------KRKEEEDQRNAAGHGSSGGGG 700
           R P       DG+         K V +++ EER      +   + +++ ++   SS   G
Sbjct: 226 RPPRERFELGDGR---------KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG 276

Query: 701 GNTQDECAEYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRS 760
             +++E  E  E+ + G  S + ES+   + + +      +  +   E+ AE  +E   S
Sbjct: 277 SGSEEEEEEEEEEEEEG--STSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS 334

Query: 761 RSNGTGSESGKDTCDEFRSQMKNGK 785
                 +E+      E R    +G+
Sbjct: 335 EDEERENENHLLVVPESRFDRDSGE 359



 Score = 34.3 bits (77), Expect = 0.66
 Identities = 36/234 (15%), Positives = 89/234 (38%), Gaps = 15/234 (6%)

Query: 537 KLEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPI-EGLDGKI 595
           +LE+ E+K ++E K + + ++ + +  +E  +E R   R  R   +  +  + E    K+
Sbjct: 156 RLEQLERKRERERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKV 215

Query: 596 HGNTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRG 655
             +  S       +E  E        K ++  E++   + + +  + +   + E+     
Sbjct: 216 KASHWSRSPPRPPRERFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAES 275

Query: 656 PDGKTHGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMK 715
             G     +        ++E EE    EE ++            G N+++   +  E++ 
Sbjct: 276 GSGSEEEEE------EEEEEEEEGSTSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVS 329

Query: 716 NGRLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSES 769
              +S         D + ++ N+   + +++ +R++    E       GT   S
Sbjct: 330 EEEMS--------EDEERENENHLLVVPESRFDRDSGESEEAEEEVGEGTPQSS 375


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 112/613 (18%), Positives = 220/613 (35%), Gaps = 92/613 (15%)

Query: 338 QAENEEKKKAEARARNKRESGKATSYAELCSEYRKLVRNGKLACTRENDPIQGPDGKVHG 397
           Q   E + +AE  A  + +  +     E   E R+  R  +L   +E + +        G
Sbjct: 13  QKREEMRLEAERIAYQRNDDDEE----EAARERRRRARQERLRQKQEEESL--------G 60

Query: 398 NTCSMCEVFFQAEEEEKKKKEGKSRNKRQSKSTASFEELCS---EYRKSRKNGRLFCTRE 454
                 EV  Q    +++ K   +  + +    A+F E  +   E R+ R    L   +E
Sbjct: 61  QVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKE 120

Query: 455 NDP------IQGPDGKMHGNTCSMCEAFFQQEERARAKAKREAAKEICSEFRDQVRNGTL 508
            DP      +  P  +M  +T        ++EE++ ++ +R   +E            T+
Sbjct: 121 FDPTITDASLSLPSRRMQNDTAE--NETTEKEEKSESRQERYEIEE----------TETV 168

Query: 509 ICTREHNPVRGPDGKMHGNKCAMCASVFKLEEEEKKNDKEEKGKVEAEKVKREAVQELCS 568
             + + N  R  +     +K          E+EE++ +K ++G +   +V+   V+E  +
Sbjct: 169 TKSYQKNDWRDAEENKKEDK----------EKEEEEEEKPKRGSIGENQVE-VMVEEKTT 217

Query: 569 EYRHY-----VRNGRLPCT---RENDPIEGLDGKIHGNTCSMCEAFFQQEAKEKERAEPR 620
           E +       ++NG++      +E +  +G D   H       +    +  + +  AE R
Sbjct: 218 ESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEER 277

Query: 621 AKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCAMCKAVFQKENEERK 680
            ++K E +K+  DE  R+    K    +E +     + +    +        Q+  EE K
Sbjct: 278 ERIKAEQDKKIADERARIEAEEKA-AAQERERREAEERERMREEEKRAAEERQRIKEEEK 336

Query: 681 RKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVRDADGKSYNNQC 740
           R  EE QR               +   AE R+++K        E    R  + +      
Sbjct: 337 RAAEERQRIK-----------EEEKRAAEERQRIKEEEKRAAEERQRARAEEEE------ 379

Query: 741 TMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKLICTRE-SDPVRGPD 799
              KAK+E +   K    +  +       G+    +   +  N K     +    V    
Sbjct: 380 ---KAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQ 436

Query: 800 GKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGERSNDKEDLCREFRSMQRNG 859
           G+  G K    +EKL+ +    KK+E +D           E+    ++   E +S     
Sbjct: 437 GEEKGTKVQAKREKLQEDKPTFKKEEIKD-----------EKIKKDKEPKEEVKSFMDRK 485

Query: 860 KLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERK--KKDEEKSSSKPSNNAKDQCR 917
           K         V+   G+   +K    ++ F R         K+ E +    +    ++ R
Sbjct: 486 KGF-----TEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELR 540

Query: 918 QVQNEAEDAKFRQ 930
           + + E E  +F +
Sbjct: 541 RRRGETESEEFEK 553



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 102/522 (19%), Positives = 194/522 (37%), Gaps = 56/522 (10%)

Query: 268 RFSEENSKTDQNLGKAEEKTKVKR------EIVKLCSQYQNQAKNGILFCTRENDPIRGP 321
           R +EEN K D+   + EE+ K KR      ++  +  +   +++   +  + +N  I   
Sbjct: 178 RDAEENKKEDKEK-EEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSE 236

Query: 322 DGKMHGNL---CSMCQAYFQAENEEKKKAEA-RAR---NKRESGKATSYAELCSEYRKLV 374
           + K              + + E E+K++AEA RAR    +RE  KA    ++  E  ++ 
Sbjct: 237 EPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIE 296

Query: 375 RNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNKRQSKSTASFE 434
              K A             ++        E   + +EEEK+  E + R K + K  A   
Sbjct: 297 AEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEER 356

Query: 435 ELCSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQEERARAKAKREAAKE 494
           +   E  K     R     E +     + +         +   Q+ +    K +++   +
Sbjct: 357 QRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGK 416

Query: 495 ICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFKLEE---EEKKNDKEEKG 551
             +E + Q         ++    +G   +    K       FK EE   E+ K DKE K 
Sbjct: 417 WVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKE 476

Query: 552 KVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTCSMCEAFFQQEA 611
           +V++   +++   E+ S+   ++ + +L  T       G  G+   +T    EA    + 
Sbjct: 477 EVKSFMDRKKGFTEVKSQNGEFMTH-KLKHTENTFSRPG--GRASVDTK---EAEGAPQV 530

Query: 612 KEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCAMCKAV 671
           +  +R E   + + E E E  ++ ++  Q   L                        + +
Sbjct: 531 EAGKRLEELRRRRGETESEEFEKLKQKQQEAAL----------------------ELEEL 568

Query: 672 FQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVRDA 731
            +K  E RK  EEE+QR               ++E    +E+++  R     +   + + 
Sbjct: 569 KKKREERRKVLEEEEQRRKQ---EEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPE- 624

Query: 732 DGKSYNNQCTMC------KAKLEREAERKNEYSRSRSNGTGS 767
           DG S + +   C        K+E  AE  N+ S  +S+G  S
Sbjct: 625 DGLSDDKKPFKCFTPKGSSLKIEERAEFLNK-SVQKSSGVKS 665



 Score = 39.7 bits (91), Expect = 0.016
 Identities = 91/482 (18%), Positives = 184/482 (38%), Gaps = 111/482 (23%)

Query: 410 EEEEKKKKEGKSRNKR-----QSKSTASFEELCSEYRKSRKNGRLFCT---RENDPIQGP 461
           EEEE+K K G     +     + K+T S EE       S KNG++      +E +  QG 
Sbjct: 192 EEEEEKPKRGSIGENQVEVMVEEKTTESQEETVV---MSLKNGQISSEEPKQEEEREQGS 248

Query: 462 DGKMHGNTCSMCEAFFQQEERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPD 521
           D   H           ++E++ RA+A+R   +   +E R++++        +   +    
Sbjct: 249 DEISHHEK-------MEEEDKERAEAERARLE---AEERERIK------AEQDKKIADER 292

Query: 522 GKMHGNKCAMCASVFKLEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPC 581
            ++   + A      + E EE++  +EE+ +   E+ + +  ++  +E R  ++      
Sbjct: 293 ARIEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRA 352

Query: 582 TRENDPIEGLDGKIHGNTCSMCEAFFQQEAKEKERA----EPRAKVKREAEKETCDEFRR 637
             E   I+  +               ++ A+E++RA    E +AKV+ +   +  +E + 
Sbjct: 353 AEERQRIKEEE---------------KRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKH 397

Query: 638 LLQNGKLFCTRENDPVRGP---DGKTHGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHG 694
            +Q  K+   +    + G    + K   +K  +  AV +K+ EE+  K +  +       
Sbjct: 398 AMQETKIKGEKVEQKIEGKWVNEKKAQEDK--LQTAVLKKQGEEKGTKVQAKREKLQ--- 452

Query: 695 SSGGGGGNTQDECAEYREQMKNGRLSCTRE-SDPVRD--------ADGKSYNNQCTMCKA 745
                    +D+    +E++K+ ++   +E  + V+          + KS N +    K 
Sbjct: 453 ---------EDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKL 503

Query: 746 KLER-----------------------EAERKNEYSRSRSNGTGSESGKDT--------- 773
           K                          EA ++ E  R R   T SE  +           
Sbjct: 504 KHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAAL 563

Query: 774 -CDEFRSQMKNGKLICTRESDPVRGPDGKT---HGNKCTMCKEKLER---EAAEKKKKED 826
             +E + + +  + +   E    +  +         +    KE++ER   EAAEK++K  
Sbjct: 564 ELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMP 623

Query: 827 ED 828
           ED
Sbjct: 624 ED 625



 Score = 37.0 bits (84), Expect = 0.10
 Identities = 80/439 (18%), Positives = 162/439 (36%), Gaps = 78/439 (17%)

Query: 542 EKKNDKEEKGKVEAEKVKREA----VQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHG 597
           E +  K E+ ++EAE++  +      +E   E R   R  RL   +E + +  +  ++  
Sbjct: 9   ELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEV 68

Query: 598 N--------------TCSMCE-----AFFQQEAKEKERAEPRAKVKREAEKETCDEFR-- 636
           N              T +  E     AF ++ A+ +ER + R +   E +KE        
Sbjct: 69  NAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDA 128

Query: 637 ------RLLQNG-----------KLFCTRENDPVRGPDGKTHGNKCAMCKAVFQKENEER 679
                 R +QN            K    +E   +   +  T   +    +   + + E++
Sbjct: 129 SLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDK 188

Query: 680 KRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQ-----MKNGRLSCTRESDPVRDADGK 734
           +++EEE+++   G           +++  E +E+     +KNG++S     +P ++ + +
Sbjct: 189 EKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQIS---SEEPKQEEERE 245

Query: 735 SYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKLICTRESDP 794
             +++ +  + K+E E + + E  R+R      E         R + +  K I    +  
Sbjct: 246 QGSDEISHHE-KMEEEDKERAEAERARLEAEERE---------RIKAEQDKKIADERAR- 294

Query: 795 VRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGERSNDKEDLCREFRS 854
                           +EK   +  E+++ E+ +R    E+    ER   KE+  R    
Sbjct: 295 -------------IEAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEE 341

Query: 855 MQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKDEEKSSSKPSNNAKD 914
            QR    I   E              K A  +    R   E K K EE+  +K     K 
Sbjct: 342 RQR----IKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKH 397

Query: 915 QCRQVQNEAEDAKFRQPGR 933
             ++ + + E  + +  G+
Sbjct: 398 AMQETKIKGEKVEQKIEGK 416


>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           5 [Homo sapiens]
          Length = 748

 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 55/265 (20%), Positives = 113/265 (42%), Gaps = 33/265 (12%)

Query: 537 KLEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIH 596
           +++E+E+++++ ++ + E +K +RE  ++   E        R    RE D +E L+ K  
Sbjct: 89  RVKEKEREHERRKRHREEQDKARREWERQKRREM------AREHSRRERDRLEQLERKRE 142

Query: 597 GNTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQ--NGKLFCTR-ENDPV 653
                  +   Q+E KE+ER     + +REA +E     R + +  + K+  +     P 
Sbjct: 143 RERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPP 202

Query: 654 RGP-------DGKTHGNKCAMCKAVFQKENEER------KRKEEEDQRNAAGHGSSGGGG 700
           R P       DG+         K V +++ EER      +   + +++ ++   SS   G
Sbjct: 203 RPPRERFELGDGR---------KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG 253

Query: 701 GNTQDECAEYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRS 760
             +++E  E  E+ + G  S + ES+   + + +      +  +   E+ AE  +E   S
Sbjct: 254 SGSEEEEEEEEEEEEEG--STSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS 311

Query: 761 RSNGTGSESGKDTCDEFRSQMKNGK 785
                 +E+      E R    +G+
Sbjct: 312 EDEERENENHLLVVPESRFDRDSGE 336



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 62/308 (20%), Positives = 117/308 (37%), Gaps = 52/308 (16%)

Query: 612 KEKERAEPRAKVKREAEKETCDEFRRLLQN--GKLFCTRENDPVRGPDGKTHGNKCAMCK 669
           KEKER   R K  RE + +   E+ R  +    +    RE D +   + K    +    +
Sbjct: 91  KEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQ 150

Query: 670 AVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVR 729
              Q+E +ER+R+ EE ++               +++   Y +++K    S +    P  
Sbjct: 151 QKEQREQKERERRAEERRKEREARREVSAHHRTMRED---YSDKVKASHWSRSPPRPPRE 207

Query: 730 D---ADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGS--ESGKDTCDEFRSQMKNG 784
                DG+    +  M +  L  + +  ++  R  S+   S  ESG  + +E        
Sbjct: 208 RFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEE-------- 259

Query: 785 KLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGERSND 844
                 E +     +G T         E+ E E  E++++E+E  SN+ E S        
Sbjct: 260 -----EEEEEEEEEEGST--------SEESEEEEEEEEEEEEETGSNSEEASEQSAEEVS 306

Query: 845 KEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKDEEKS 904
           +E++  +      N  L+                     + +S FDR++ E ++ +EE  
Sbjct: 307 EEEMSEDEERENENHLLV---------------------VPESRFDRDSGESEEAEEEVG 345

Query: 905 SSKPSNNA 912
              P ++A
Sbjct: 346 EGTPQSSA 353



 Score = 30.4 bits (67), Expect = 9.6
 Identities = 30/140 (21%), Positives = 62/140 (44%), Gaps = 11/140 (7%)

Query: 811 KEKLEREAAEKKKKEDEDRSNTGERSNTGERSNDKEDLCREFRSMQRNGKLICTRENNPV 870
           KEK+     EK+K++   RS++ E      R  +KE   RE    +R+       E +  
Sbjct: 60  KEKVHHRKDEKRKEKRRHRSHSAE-GGKHARVKEKE---REHERRKRH-----REEQDKA 110

Query: 871 RGPYGKMHINKCAMCQSIFDREANER--KKKDEEKSSSKPSNNAKDQCRQVQNEAEDAKF 928
           R  + +    + A   S  +R+  E+  +K++ E+   +     ++Q  + +   E  K 
Sbjct: 111 RREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQKEQREQKERERRAEERRKE 170

Query: 929 RQPGRSLASVARMSTDECSE 948
           R+  R +++  R   ++ S+
Sbjct: 171 REARREVSAHHRTMREDYSD 190


>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           4 [Homo sapiens]
          Length = 737

 Score = 47.0 bits (110), Expect = 1e-04
 Identities = 55/265 (20%), Positives = 113/265 (42%), Gaps = 33/265 (12%)

Query: 537 KLEEEEKKNDKEEKGKVEAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIH 596
           +++E+E+++++ ++ + E +K +RE  ++   E        R    RE D +E L+ K  
Sbjct: 78  RVKEKEREHERRKRHREEQDKARREWERQKRREM------AREHSRRERDRLEQLERKRE 131

Query: 597 GNTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQ--NGKLFCTR-ENDPV 653
                  +   Q+E KE+ER     + +REA +E     R + +  + K+  +     P 
Sbjct: 132 RERKMREQQKEQREQKERERRAEERRKEREARREVSAHHRTMREDYSDKVKASHWSRSPP 191

Query: 654 RGP-------DGKTHGNKCAMCKAVFQKENEER------KRKEEEDQRNAAGHGSSGGGG 700
           R P       DG+         K V +++ EER      +   + +++ ++   SS   G
Sbjct: 192 RPPRERFELGDGR---------KPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESG 242

Query: 701 GNTQDECAEYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRS 760
             +++E  E  E+ + G  S + ES+   + + +      +  +   E+ AE  +E   S
Sbjct: 243 SGSEEEEEEEEEEEEEG--STSEESEEEEEEEEEEEEETGSNSEEASEQSAEEVSEEEMS 300

Query: 761 RSNGTGSESGKDTCDEFRSQMKNGK 785
                 +E+      E R    +G+
Sbjct: 301 EDEERENENHLLVVPESRFDRDSGE 325



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 62/308 (20%), Positives = 117/308 (37%), Gaps = 52/308 (16%)

Query: 612 KEKERAEPRAKVKREAEKETCDEFRRLLQN--GKLFCTRENDPVRGPDGKTHGNKCAMCK 669
           KEKER   R K  RE + +   E+ R  +    +    RE D +   + K    +    +
Sbjct: 80  KEKEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQ 139

Query: 670 AVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVR 729
              Q+E +ER+R+ EE ++               +++   Y +++K    S +    P  
Sbjct: 140 QKEQREQKERERRAEERRKEREARREVSAHHRTMRED---YSDKVKASHWSRSPPRPPRE 196

Query: 730 D---ADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGS--ESGKDTCDEFRSQMKNG 784
                DG+    +  M +  L  + +  ++  R  S+   S  ESG  + +E        
Sbjct: 197 RFELGDGRKPVKEEKMEERDLLSDLQDISDSERKTSSAESSSAESGSGSEEE-------- 248

Query: 785 KLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGERSND 844
                 E +     +G T         E+ E E  E++++E+E  SN+ E S        
Sbjct: 249 -----EEEEEEEEEEGST--------SEESEEEEEEEEEEEEETGSNSEEASEQSAEEVS 295

Query: 845 KEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMCQSIFDREANERKKKDEEKS 904
           +E++  +      N  L+                     + +S FDR++ E ++ +EE  
Sbjct: 296 EEEMSEDEERENENHLLV---------------------VPESRFDRDSGESEEAEEEVG 334

Query: 905 SSKPSNNA 912
              P ++A
Sbjct: 335 EGTPQSSA 342


>gi|153945790 myosin, heavy chain 8, skeletal muscle, perinatal [Homo
            sapiens]
          Length = 1937

 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 161/791 (20%), Positives = 299/791 (37%), Gaps = 119/791 (15%)

Query: 227  EYEKQV-RNGRLFCTRESDPVRGPDGRMHGNKCALCAEIFKQRFSEENSKTDQNLGKAEE 285
            EY+K + R   LFC + +  VR      H     L    FK +   ++++T++ +   +E
Sbjct: 803  EYQKMLQRREALFCIQYN--VRAFMNVKHWPWMKL---FFKIKPLLKSAETEKEMATMKE 857

Query: 286  K-TKVKREIVKLCSQYQNQAKNGILFCTRENDPIRGPDGKMHGNLCSMCQAYFQAENEEK 344
            +  K K E+ K  ++ +   +  +     +ND       ++     S+  A  + E   K
Sbjct: 858  EFQKTKDELAKSEAKRKELEEKMVTLLKEKNDL----QLQVQSEADSLADAEERCEQLIK 913

Query: 345  KKAEARARNKRESGKATSYAELCSEYRKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCE 404
             K +  A+ K  + +A    E+ +E     R  +  C+     I               E
Sbjct: 914  NKIQLEAKIKEVTERAEEEEEINAELTAKKRKLEDECSELKKDIDD------------LE 961

Query: 405  VFFQAEEEEKKKKEGKSRNKRQSKSTASFEELCSEYRKSRKNGRLFCTRENDPIQGPDGK 464
            +     E+EK   E K +N   ++  A  +E  ++  K +K  +    +  D +Q  + K
Sbjct: 962  LTLAKVEKEKHATENKVKNL--TEEMAGLDETIAKLSKEKKALQETHQQTLDDLQAEEDK 1019

Query: 465  MHGNTCSMCEAFFQQEERARAKAKREAAKEICSEFRDQVRNGTLICTRE-----HNPVRG 519
            ++  T +  +   QQ +      ++E    +  E   +   G L   +E      N  + 
Sbjct: 1020 VNILTKAKTK-LEQQVDDLEGSLEQEKKLRMDLERAKRKLEGDLKLAQESTMDMENDKQQ 1078

Query: 520  PDGKMHGNKCAMCASVFKLEEEE------KKNDKEEKGKVE--AEKVKREAVQELCSEYR 571
             D K+   +  +   + K+E+E+      +K  KE + ++E   E+++ E      +E +
Sbjct: 1079 LDEKLEKKEFEISNLISKIEDEQAVEIQLQKKIKELQARIEELGEEIEAERASRAKAEKQ 1138

Query: 572  HYVRNGRLPCTRENDPIEGLDGKIHGNTCSMCE------AFFQ------QEAKEKERAEP 619
                  R   +RE + I     +  G T +  E      A FQ      +EA  +  A  
Sbjct: 1139 ------RSDLSRELEEISERLEEAGGATSAQVELNKKREAEFQKLRRDLEEATLQHEAMV 1192

Query: 620  RAKVKREAEK-----ETCDEFRRL---LQNGKLFCTRENDPVRGPD---GKTHGNKCAMC 668
             A  K+ A+      E  D  +R+   L+  K     E D +        K  GN   MC
Sbjct: 1193 AALRKKHADSMAELGEQIDNLQRVKQKLEKEKSELKMETDDLSSNAEAISKAKGNLEKMC 1252

Query: 669  KAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQM--KNGRLSCTRESD 726
            +++ + +  E K KEEE QR               Q E  EY  Q+  K+  +S    S 
Sbjct: 1253 RSL-EDQVSELKTKEEEQQRLI---NDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSK 1308

Query: 727  PVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQM---KN 783
                   ++   Q    K +LE E + KN  + +       +S +  CD  R Q    + 
Sbjct: 1309 -------QASTQQIEELKHQLEEETKAKNALAHA------LQSSRHDCDLLREQYEEEQE 1355

Query: 784  GKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDEDRSNTGERSNTGERSN 843
            GK    R              ++    + K E +A ++ ++ +E +    +R    E   
Sbjct: 1356 GKAELQRALSKA--------NSEVAQWRTKYETDAIQRTEELEEAKKKLAQRLQ--EAEE 1405

Query: 844  DKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCAMC-----QSIFDREANERKK 898
              E +  +  S+++  +    R  N V      +  +  A       Q  FD+  +E K+
Sbjct: 1406 HVEAVNAKCASLEKTKQ----RLQNEVEDLMLDVERSNAACAALDKKQRNFDKVLSEWKQ 1461

Query: 899  KDEE-----KSSSKPSNNAKDQCRQVQNEAEDA-----KFRQPGRSLASVARMSTDECSE 948
            K EE     ++S K S +   +  +V+N  E++       R+  ++L       T++ +E
Sbjct: 1462 KYEETQAELEASQKESRSLSTELFKVKNVYEESLDQLETLRRENKNLQQEISDLTEQIAE 1521

Query: 949  FRNYIRNNELI 959
                I   E I
Sbjct: 1522 GGKQIHELEKI 1532



 Score = 33.9 bits (76), Expect = 0.86
 Identities = 49/209 (23%), Positives = 85/209 (40%), Gaps = 30/209 (14%)

Query: 811  KEKLEREAAEKKKKEDEDRSNTGERSNTGERSNDKEDLCREFRSMQRNGKLICTRENNPV 870
            K+KLE+E +E K + D+  SN    S   +   + E +C   RS++     + T+E    
Sbjct: 1217 KQKLEKEKSELKMETDDLSSNAEAIS---KAKGNLEKMC---RSLEDQVSELKTKEEEQQ 1270

Query: 871  RGPYGKMHINKCAMCQSIFDREANERKKKDEEKSS-----SKPSNNAKDQCRQVQNEAED 925
            R       IN     ++    EA E  ++ +EK +     S+    +  Q  +++++ E+
Sbjct: 1271 R------LINDLTAQRARLQTEAGEYSRQLDEKDALVSQLSRSKQASTQQIEELKHQLEE 1324

Query: 926  AKFRQPGRSLASVARMSTDECSEFRNYI---RNNELICPRENDPVHGADGKFYTNKCYMC 982
                +   +LA   + S  +C   R      +  +    R     +    ++ T   Y  
Sbjct: 1325 E--TKAKNALAHALQSSRHDCDLLREQYEEEQEGKAELQRALSKANSEVAQWRTK--YET 1380

Query: 983  RAVFLTEALERAK------LQEKPSHVRA 1005
             A+  TE LE AK      LQE   HV A
Sbjct: 1381 DAIQRTEELEEAKKKLAQRLQEAEEHVEA 1409


>gi|47679099 Kazal type serine protease inhibitor 5-like 2 [Homo
           sapiens]
          Length = 97

 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 18/41 (43%), Positives = 26/41 (63%)

Query: 111 CPDYYEAVCGTDGKTYDNRCALCAENAKTGSQIGVKSEGEC 151
           CP  Y+ +CGT+  TYDN C LC E+ K+  +I    +G+C
Sbjct: 57  CPGLYQPICGTNFITYDNPCILCVESLKSHGRIRFYHDGKC 97



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 17/41 (41%), Positives = 23/41 (56%)

Query: 1036 CPKDLKPVCGDDGQTYNNPCMLCHENLIRQTNTHIRSTGKC 1076
            CP   +P+CG +  TY+NPC+LC E+L           GKC
Sbjct: 57   CPGLYQPICGTNFITYDNPCILCVESLKSHGRIRFYHDGKC 97


>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
          Length = 2454

 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 109/613 (17%), Positives = 220/613 (35%), Gaps = 91/613 (14%)

Query: 260  LCAEIFKQRFSEENSKTDQNLGK--AEEKTK---VKREIVKLCSQYQNQAKNGILFCTRE 314
            +  +  K+  S+E S+ D+   K   EEK K    K++++K+  QY++ +        RE
Sbjct: 926  IAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPERE 985

Query: 315  NDPIRGPDGKMHGNLCSMCQAYFQAENE----EKKKAEARARNKRESGKATSYAELCSEY 370
                          +C   +   Q +N     EKK  + R +  ++  + + YAE     
Sbjct: 986  E-------------ICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAE----- 1027

Query: 371  RKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNKRQSKST 430
                       T + D     + K   N            E+++ K  GKS  KRQ  S+
Sbjct: 1028 ---------KSTGKGDSCDSSEDKKSKNGA-------YGREKKRCKLLGKSSRKRQDCSS 1071

Query: 431  ASFEEL------CSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQEERAR 484
            +  E+       C+   K  K   L   R     +       G++ S  E   +  E  +
Sbjct: 1072 SDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAE---ESSEDNK 1128

Query: 485  AKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFKLEEEEKK 544
             K +R ++K+     +++ RN     T+               K A   S    + E+  
Sbjct: 1129 KKKQRTSSKKKAVIVKEKKRNSLRTSTKR--------------KQADITSSSSSDIEDDD 1174

Query: 545  NDKEEKGKVEAEKVKREAVQELCSEYRHYVRNG-------RLPCT-----RENDPIEGLD 592
             +   +G  + +K+K      + S +  + ++         +P T      +NDP   + 
Sbjct: 1175 QNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIA 1234

Query: 593  GKIHGNTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDP 652
             K+         +  +  + + E  E + +  ++ E+   DE  +   N +     ++D 
Sbjct: 1235 KKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSE----SDSDS 1290

Query: 653  VRGPDGKTHGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYRE 712
                  +           V   E+ E K+ + ++ +   G         +++D  ++++E
Sbjct: 1291 EESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSED--SDFQE 1348

Query: 713  QMKNGRLSCTRESDPVRDADGKSY----NNQCTMCKAKLEREAERKNEYSRSRSNGTGSE 768
               +  +S + +    R    K      N +    K K  R   +++  S ++SN    E
Sbjct: 1349 SGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEE 1408

Query: 769  SGKDTCDEFRSQMKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDED 828
              K+  +E   + +  +     E+D  + P       +  +  +KL  E     K+E+E 
Sbjct: 1409 EEKEEEEEEEEEEEEEE---EDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEER 1465

Query: 829  RSNTGERSNTGER 841
            R    ER    E+
Sbjct: 1466 RKRIAEREREREK 1478



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 46/211 (21%), Positives = 86/211 (40%), Gaps = 25/211 (11%)

Query: 750  EAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKLICTRESDPVRGPDGKTHGNKCTM 809
            + E KN+ + S S+    ES K     +R ++   KL  +         DG++   K T 
Sbjct: 1275 DEEAKNQVN-SESDSDSEESKKP---RYRHRLLRHKLTVS---------DGESGEEKKTK 1321

Query: 810  CKEKLEREAAEKKKKEDEDRSNTG-ERSNTGERSNDKEDLCREFRSMQRNGKLICTRENN 868
             KE  E +   ++K   ED  ++  + S   E  ++ ED   E R   R+ K     EN 
Sbjct: 1322 PKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESED---EQRPRTRSAKKAELEENQ 1378

Query: 869  PVRGPYGKMHINKCAMCQSIFDREANERKKKDEEKSSSKPSNNAKDQCRQVQNEAEDAKF 928
                   K    K      + +  ++E K   EE+   K     +++  + + E E+   
Sbjct: 1379 RSYKQKKKRRRIK------VQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDS 1432

Query: 929  RQPGRSLASVARMSTDE--CSEFRNYIRNNE 957
            + PG+    + ++  D+   +E +N ++  E
Sbjct: 1433 KSPGKGRKKIRKILKDDKLRTETQNALKEEE 1463


>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
          Length = 2492

 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 109/613 (17%), Positives = 220/613 (35%), Gaps = 91/613 (14%)

Query: 260  LCAEIFKQRFSEENSKTDQNLGK--AEEKTK---VKREIVKLCSQYQNQAKNGILFCTRE 314
            +  +  K+  S+E S+ D+   K   EEK K    K++++K+  QY++ +        RE
Sbjct: 964  IAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGTEKLPERE 1023

Query: 315  NDPIRGPDGKMHGNLCSMCQAYFQAENE----EKKKAEARARNKRESGKATSYAELCSEY 370
                          +C   +   Q +N     EKK  + R +  ++  + + YAE     
Sbjct: 1024 E-------------ICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAE----- 1065

Query: 371  RKLVRNGKLACTRENDPIQGPDGKVHGNTCSMCEVFFQAEEEEKKKKEGKSRNKRQSKST 430
                       T + D     + K   N            E+++ K  GKS  KRQ  S+
Sbjct: 1066 ---------KSTGKGDSCDSSEDKKSKNGA-------YGREKKRCKLLGKSSRKRQDCSS 1109

Query: 431  ASFEEL------CSEYRKSRKNGRLFCTRENDPIQGPDGKMHGNTCSMCEAFFQQEERAR 484
            +  E+       C+   K  K   L   R     +       G++ S  E   +  E  +
Sbjct: 1110 SDTEKYSMKEDGCNSSDKRLKRIELRERRNLSSKRNTKEIQSGSSSSDAE---ESSEDNK 1166

Query: 485  AKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHGNKCAMCASVFKLEEEEKK 544
             K +R ++K+     +++ RN     T+               K A   S    + E+  
Sbjct: 1167 KKKQRTSSKKKAVIVKEKKRNSLRTSTKR--------------KQADITSSSSSDIEDDD 1212

Query: 545  NDKEEKGKVEAEKVKREAVQELCSEYRHYVRNG-------RLPCT-----RENDPIEGLD 592
             +   +G  + +K+K      + S +  + ++         +P T      +NDP   + 
Sbjct: 1213 QNSIGEGSSDEQKIKPVTENLVLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDPENRIA 1272

Query: 593  GKIHGNTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDP 652
             K+         +  +  + + E  E + +  ++ E+   DE  +   N +     ++D 
Sbjct: 1273 KKMLLEEIKANLSSDEDGSSDDEPEEGKKRTGKQNEENPGDEEAKNQVNSE----SDSDS 1328

Query: 653  VRGPDGKTHGNKCAMCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYRE 712
                  +           V   E+ E K+ + ++ +   G         +++D  ++++E
Sbjct: 1329 EESKKPRYRHRLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSED--SDFQE 1386

Query: 713  QMKNGRLSCTRESDPVRDADGKSY----NNQCTMCKAKLEREAERKNEYSRSRSNGTGSE 768
               +  +S + +    R    K      N +    K K  R   +++  S ++SN    E
Sbjct: 1387 SGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSEEEE 1446

Query: 769  SGKDTCDEFRSQMKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKEDED 828
              K+  +E   + +  +     E+D  + P       +  +  +KL  E     K+E+E 
Sbjct: 1447 EEKEEEEEEEEEEEEEE---EDENDDSKSPGKGRKKIRKILKDDKLRTETQNALKEEEER 1503

Query: 829  RSNTGERSNTGER 841
            R    ER    E+
Sbjct: 1504 RKRIAEREREREK 1516



 Score = 40.0 bits (92), Expect = 0.012
 Identities = 46/211 (21%), Positives = 86/211 (40%), Gaps = 25/211 (11%)

Query: 750  EAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKLICTRESDPVRGPDGKTHGNKCTM 809
            + E KN+ + S S+    ES K     +R ++   KL  +         DG++   K T 
Sbjct: 1313 DEEAKNQVN-SESDSDSEESKKP---RYRHRLLRHKLTVS---------DGESGEEKKTK 1359

Query: 810  CKEKLEREAAEKKKKEDEDRSNTG-ERSNTGERSNDKEDLCREFRSMQRNGKLICTRENN 868
             KE  E +   ++K   ED  ++  + S   E  ++ ED   E R   R+ K     EN 
Sbjct: 1360 PKEHKEVKGRNRRKVSSEDSEDSDFQESGVSEEVSESED---EQRPRTRSAKKAELEENQ 1416

Query: 869  PVRGPYGKMHINKCAMCQSIFDREANERKKKDEEKSSSKPSNNAKDQCRQVQNEAEDAKF 928
                   K    K      + +  ++E K   EE+   K     +++  + + E E+   
Sbjct: 1417 RSYKQKKKRRRIK------VQEDSSSENKSNSEEEEEEKEEEEEEEEEEEEEEEDENDDS 1470

Query: 929  RQPGRSLASVARMSTDE--CSEFRNYIRNNE 957
            + PG+    + ++  D+   +E +N ++  E
Sbjct: 1471 KSPGKGRKKIRKILKDDKLRTETQNALKEEE 1501


>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
           [Homo sapiens]
          Length = 624

 Score = 46.2 bits (108), Expect = 2e-04
 Identities = 60/265 (22%), Positives = 96/265 (36%), Gaps = 34/265 (12%)

Query: 608 QQEAKEKERAEPRAKVK-REAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCA 666
           +++ KEKER + + + K RE EKE                 RE +  RG +      +  
Sbjct: 381 REKIKEKERVKEKDREKEREREKE-----------------REKEKERGKNKDRDKER-- 421

Query: 667 MCKAVFQKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESD 726
                 +K+ E+ K K+ E +R               QD+  E RE+ ++  +   R+ D
Sbjct: 422 ------EKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKE-REKDRSKEIDEKRKKD 474

Query: 727 PVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKL 786
                  +SYN       +  ER   R    SRS       +         RS+ K  K 
Sbjct: 475 KKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDK- 533

Query: 787 ICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKKKED----EDRSNTGERSNTGERS 842
              RE +     + +      +M K   +R+  EK +K      E   N    S+  +  
Sbjct: 534 --KREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEV 591

Query: 843 NDKEDLCREFRSMQRNGKLICTREN 867
           +DK+    E   +Q NG      EN
Sbjct: 592 DDKDAPRTEENKIQHNGNCQLNEEN 616



 Score = 44.7 bits (104), Expect = 5e-04
 Identities = 71/370 (19%), Positives = 134/370 (36%), Gaps = 24/370 (6%)

Query: 704  QDECAEYREQMKNGRLSCTRESDPVRDADGKSYNNQCTMCKAKLEREAERKNEYSRSRSN 763
            Q    E  E MK  R + +  S  +    GKS            ER+  R   ++RS+S 
Sbjct: 269  QAAAKELEEVMKRVREAQSFISAAIEPESGKSN-----------ERKGGRSRSHTRSKSR 317

Query: 764  GTGSESGKDTCDEFRSQMKNGKLICTRESDPVRGPDGKTHGNKCTMCKEKLEREAAEKKK 823
             +     +    + + + ++     +R+ D  R        +K    ++   R  +  K+
Sbjct: 318  SSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKR 377

Query: 824  KEDEDRSNTGERSNTGERSNDKEDLCREFRSMQRNGKLICTRENNPVRGPYGKMHINKCA 883
            K+  ++    ER    +R  ++E      +  +R       +E    R    +    +  
Sbjct: 378  KDTREKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERER 437

Query: 884  MCQSIFDREANERKKKDEEKSSSKPSNNAKDQCRQVQNEAEDAKFRQPGRSLASVARMST 943
              +   DR+  + K++D+EK   K  +   D+ R+     +D K R P RS  + +R S 
Sbjct: 438  EKEHEKDRDKEKEKEQDKEKEREKDRSKEIDEKRK-----KDKKSRTPPRSY-NASRRSR 491

Query: 944  DECSEFRNYIRNNELICPRENDPVHGADGKFYT----NKCYMCRAVFLTEALERAKLQEK 999
                E R     +    PR +  +     +  +    NK    R        ER + +  
Sbjct: 492  SSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERS 551

Query: 1000 PSHVRASQEEDSPDSFSSLDSEMC-KDYRVLPRIGYLCPKDLK--PVCGDDGQTYNNPCM 1056
             S  ++S + D  +      + +  K++   P        D K  P   ++   +N  C 
Sbjct: 552  TSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQ 611

Query: 1057 LCHENLIRQT 1066
            L  ENL  +T
Sbjct: 612  LNEENLSTKT 621



 Score = 35.0 bits (79), Expect = 0.39
 Identities = 59/321 (18%), Positives = 121/321 (37%), Gaps = 15/321 (4%)

Query: 554 EAEKVKREAVQELCSEYRHYVRNGRLPCTRENDPIEGLDGKIHGNTCSMCEAFFQQEAKE 613
           +A   + E V +   E + ++     P + +++  +G  G+   +T S   +  +  ++ 
Sbjct: 269 QAAAKELEEVMKRVREAQSFISAAIEPESGKSNERKG--GRSRSHTRSKSRSSSKSHSRR 326

Query: 614 KE-RAEPRAKVKREAEKETCDEFRRLLQNGKLFCTRENDPVRGPDGKTHGNKCAMCKAVF 672
           K  +++ R++    +     D  R    + K   +RE    R         K    K   
Sbjct: 327 KRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKE 386

Query: 673 QKENEERKRKEEEDQRNAAGHGSSGGGGGNTQDECAEYREQMKNGRLSCTRESDPVRDAD 732
           ++  +E+ R++E ++          G   +   E  + RE+ K       RE +  +D D
Sbjct: 387 KERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRD 446

Query: 733 GKSYNNQCTMCKAKLEREAERKNEYSRSRSNGTGSESGKDTCDEFRSQMKNGKLICTRES 792
            +    Q      + ERE +R  E    R     S +   + +  R    + +    R S
Sbjct: 447 KEKEKEQ----DKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRS 502

Query: 793 -DPVRGP-DGKTHGNKCTMCKEKLEREAAEKKKKEDED---RSNTGERSNTGERSNDKED 847
               R P   KT   K +       R   +KK++++ D        ERS +  +S++  D
Sbjct: 503 RSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRD 562

Query: 848 LCREFRSMQRNGKLICTRENN 868
                  +++N   +  +E+N
Sbjct: 563 ---GKEKLEKNSTSLKEKEHN 580



 Score = 32.3 bits (72), Expect = 2.5
 Identities = 73/364 (20%), Positives = 135/364 (37%), Gaps = 63/364 (17%)

Query: 412 EEKKKKEGKSRNKRQSKSTASFEELCSEYR-----KSRKNGRLFCTRENDPIQGPDGKMH 466
           +  ++K G+SR+  +SKS +S +      R     +SR + R    +++        K  
Sbjct: 299 KSNERKGGRSRSHTRSKSRSSSKSHSRRKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKR 358

Query: 467 GNTCSMCEAFFQQEERARAKAKREAAKEICSEFRDQVRNGTLICTREHNPVRGPDGKMHG 526
             +    ++  +   R + K  RE  KE     +++V+       RE    R  + K  G
Sbjct: 359 SKSRERRKSRSRSHSRDKRKDTREKIKE-----KERVKEKDREKEREREKEREKE-KERG 412

Query: 527 NKCAMCASVFKLEEEEKKNDKEEKGKVEAEKVK-REAVQELCSEYRHYVRNGRLPCTREN 585
                     K  E++K+ D+E + + E EK + +E  +E   E             RE 
Sbjct: 413 KNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEKE-----------REK 461

Query: 586 DPIEGLDGKIHGNTCSMCEAFFQQEAKEKERAEPRAKVKREAEKETCDEFRRLLQNGKLF 645
           D  + +D K              ++  +K R  PR+       + +  E RR        
Sbjct: 462 DRSKEIDEK--------------RKKDKKSRTPPRSYNASRRSRSSSRERRR-------- 499

Query: 646 CTRENDPVRGP-DGKTHGNKCAMCKAVFQKENEERKRKEEED--------QRNAAGHGSS 696
             R     R P   KT   K +   +   +  +++KR++E D        +R+ +   SS
Sbjct: 500 -RRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSS 558

Query: 697 GGGGGNTQDE----CAEYREQMKNGRLSCTRESD----PVRDADGKSYNNQCTMCKAKLE 748
               G  + E      + +E  K    S ++E D    P  + +   +N  C + +  L 
Sbjct: 559 NDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNEENLS 618

Query: 749 REAE 752
            + E
Sbjct: 619 TKTE 622


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.130    0.389 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 48,646,250
Number of Sequences: 37866
Number of extensions: 2496177
Number of successful extensions: 15327
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 79
Number of HSP's successfully gapped in prelim test: 327
Number of HSP's that attempted gapping in prelim test: 11325
Number of HSP's gapped (non-prelim): 2668
length of query: 1094
length of database: 18,247,518
effective HSP length: 113
effective length of query: 981
effective length of database: 13,968,660
effective search space: 13703255460
effective search space used: 13703255460
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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