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Search of human proteins with 188497648
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|188497648 ubiquitin specific peptidase 37 [Homo sapiens]
(979 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|188497648 ubiquitin specific peptidase 37 [Homo sapiens] 1944 0.0
gi|10190742 ubiquitin specific peptidase 29 [Homo sapiens] 696 0.0
gi|13994268 ubiquitin-specific protease 26 [Homo sapiens] 623 e-178
gi|32698815 ubiquitin thiolesterase 12 [Homo sapiens] 93 1e-18
gi|197116355 ubiquitin specific peptidase 46 isoform 2 [Homo sap... 89 3e-17
gi|31377709 ubiquitin specific peptidase 46 isoform 1 [Homo sapi... 89 3e-17
gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo sapi... 87 6e-17
gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens] 87 1e-16
gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens] 81 5e-15
gi|62243586 ubiquitin-specific protease 21 [Homo sapiens] 76 1e-13
gi|74027267 ubiquitin-specific protease 21 [Homo sapiens] 76 1e-13
gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens] 74 7e-13
gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens] 74 7e-13
gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens] 74 7e-13
gi|57529246 ubiquitin thioesterase 19 [Homo sapiens] 74 9e-13
gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens] 72 3e-12
gi|45267835 ubiquitin specific protease 50 [Homo sapiens] 70 7e-12
gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens] 66 2e-10
gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens] 66 2e-10
gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens] 65 2e-10
gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens] 65 4e-10
gi|149192845 ubiquitin specific protease 24 [Homo sapiens] 63 2e-09
gi|22550104 ubiquitin specific protease 32 [Homo sapiens] 62 3e-09
gi|109638751 ubiquitin specific protease 6 [Homo sapiens] 61 6e-09
gi|41152235 ubiquitin specific protease 51 [Homo sapiens] 61 6e-09
gi|50312666 ubiquitin specific peptidase 25 [Homo sapiens] 59 2e-08
gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens] 59 2e-08
gi|21361749 ubiquitin thioesterase 49 [Homo sapiens] 59 2e-08
gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens] 58 4e-08
gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens] 58 4e-08
>gi|188497648 ubiquitin specific peptidase 37 [Homo sapiens]
Length = 979
Score = 1944 bits (5037), Expect = 0.0
Identities = 979/979 (100%), Positives = 979/979 (100%)
Query: 1 MSPLKIHGPIRIRSMQTGITKWKEGSFEIVEKENKVSLVVHYNTGGIPRIFQLSHNIKNV 60
MSPLKIHGPIRIRSMQTGITKWKEGSFEIVEKENKVSLVVHYNTGGIPRIFQLSHNIKNV
Sbjct: 1 MSPLKIHGPIRIRSMQTGITKWKEGSFEIVEKENKVSLVVHYNTGGIPRIFQLSHNIKNV 60
Query: 61 VLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFLDAVHQNRLPAAMKPSQGSGSF 120
VLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFLDAVHQNRLPAAMKPSQGSGSF
Sbjct: 61 VLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFLDAVHQNRLPAAMKPSQGSGSF 120
Query: 121 GAILGSRTSQKETSRQLSYSDNQASAKRGSLETKDDIPFRKVLGNPGRGSIKTVAGSGIA 180
GAILGSRTSQKETSRQLSYSDNQASAKRGSLETKDDIPFRKVLGNPGRGSIKTVAGSGIA
Sbjct: 121 GAILGSRTSQKETSRQLSYSDNQASAKRGSLETKDDIPFRKVLGNPGRGSIKTVAGSGIA 180
Query: 181 RTIPSLTSTSTPLRSGLLENRTEKRKRMISTGSELNEDYPKENDSSSNNKAMTDPSRKYL 240
RTIPSLTSTSTPLRSGLLENRTEKRKRMISTGSELNEDYPKENDSSSNNKAMTDPSRKYL
Sbjct: 181 RTIPSLTSTSTPLRSGLLENRTEKRKRMISTGSELNEDYPKENDSSSNNKAMTDPSRKYL 240
Query: 241 TSSREKQLSLKQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGTNLDRTNVSSQTPSAKR 300
TSSREKQLSLKQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGTNLDRTNVSSQTPSAKR
Sbjct: 241 TSSREKQLSLKQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGTNLDRTNVSSQTPSAKR 300
Query: 301 SLGFLPQPVPLSVKKLRCNQDYTGWNKPRVPLSSHQQQQLQGFSNLGNTCYMNAILQSLF 360
SLGFLPQPVPLSVKKLRCNQDYTGWNKPRVPLSSHQQQQLQGFSNLGNTCYMNAILQSLF
Sbjct: 301 SLGFLPQPVPLSVKKLRCNQDYTGWNKPRVPLSSHQQQQLQGFSNLGNTCYMNAILQSLF 360
Query: 361 SLQSFANDLLKQGIPWKKIPLNALIRRFAHLLVKKDICNSETKKDLLKKVKNAISATAER 420
SLQSFANDLLKQGIPWKKIPLNALIRRFAHLLVKKDICNSETKKDLLKKVKNAISATAER
Sbjct: 361 SLQSFANDLLKQGIPWKKIPLNALIRRFAHLLVKKDICNSETKKDLLKKVKNAISATAER 420
Query: 421 FSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTEPVSGEENSPDISATRAYTCPVITNLE 480
FSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTEPVSGEENSPDISATRAYTCPVITNLE
Sbjct: 421 FSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTEPVSGEENSPDISATRAYTCPVITNLE 480
Query: 481 FEVQHSIICKACGEIIPKREQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELEYSCEK 540
FEVQHSIICKACGEIIPKREQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELEYSCEK
Sbjct: 481 FEVQHSIICKACGEIIPKREQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELEYSCEK 540
Query: 541 CGGKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTENTKP 600
CGGKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTENTKP
Sbjct: 541 CGGKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTENTKP 600
Query: 601 PFTLGWSAHMAISRPLKASQMVNSCITSPSTPSKKFTFKSKSSLALCLDSDSEDELKRSV 660
PFTLGWSAHMAISRPLKASQMVNSCITSPSTPSKKFTFKSKSSLALCLDSDSEDELKRSV
Sbjct: 601 PFTLGWSAHMAISRPLKASQMVNSCITSPSTPSKKFTFKSKSSLALCLDSDSEDELKRSV 660
Query: 661 ALSQRLCEMLGNEQQQEDLEKDSKLCPIEPDKSELENSGFDRMSEEELLAAVLEISKRDA 720
ALSQRLCEMLGNEQQQEDLEKDSKLCPIEPDKSELENSGFDRMSEEELLAAVLEISKRDA
Sbjct: 661 ALSQRLCEMLGNEQQQEDLEKDSKLCPIEPDKSELENSGFDRMSEEELLAAVLEISKRDA 720
Query: 721 SPSLSHEDDDKPTSSPDTGFAEDDIQEMPENPDTMETEKPKTITELDPASFTEITKDCDE 780
SPSLSHEDDDKPTSSPDTGFAEDDIQEMPENPDTMETEKPKTITELDPASFTEITKDCDE
Sbjct: 721 SPSLSHEDDDKPTSSPDTGFAEDDIQEMPENPDTMETEKPKTITELDPASFTEITKDCDE 780
Query: 781 NKENKTPEGSQGEVDWLQQYDMEREREEQELQQALAQSLQEQEAWEQKEDDDLKRATELS 840
NKENKTPEGSQGEVDWLQQYDMEREREEQELQQALAQSLQEQEAWEQKEDDDLKRATELS
Sbjct: 781 NKENKTPEGSQGEVDWLQQYDMEREREEQELQQALAQSLQEQEAWEQKEDDDLKRATELS 840
Query: 841 LQEFNNSFVDALGSDEDSGNEDVFDMEYTEAEAEELKRNAETGNLPHSYRLISVVSHIGS 900
LQEFNNSFVDALGSDEDSGNEDVFDMEYTEAEAEELKRNAETGNLPHSYRLISVVSHIGS
Sbjct: 841 LQEFNNSFVDALGSDEDSGNEDVFDMEYTEAEAEELKRNAETGNLPHSYRLISVVSHIGS 900
Query: 901 TSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEAAVQSDRDRSGYIFFYMHKEIFDELLET 960
TSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEAAVQSDRDRSGYIFFYMHKEIFDELLET
Sbjct: 901 TSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEAAVQSDRDRSGYIFFYMHKEIFDELLET 960
Query: 961 EKNSQSLSTEVGKTTRQAS 979
EKNSQSLSTEVGKTTRQAS
Sbjct: 961 EKNSQSLSTEVGKTTRQAS 979
>gi|10190742 ubiquitin specific peptidase 29 [Homo sapiens]
Length = 922
Score = 696 bits (1795), Expect = 0.0
Identities = 438/978 (44%), Positives = 587/978 (60%), Gaps = 78/978 (7%)
Query: 1 MSPLKIHGPIRIRSMQTGITKWKEGSFEIVEKENKVSLVVHYNTGGIPRIFQLSHNIKNV 60
M LK+ G I+I S +TG+TK KE E V+++ ++ LVV + +G RIFQLS+NI++V
Sbjct: 1 MISLKVCGFIQIWSQKTGMTKLKEALIETVQRQKEIKLVVTFKSGKFIRIFQLSNNIRSV 60
Query: 61 VLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFLDAVHQNRLPAAMKPSQGSGSF 120
VLR +QS L LTL++N FL IDK+ +DA+++ +FLD +HQN+ MK S
Sbjct: 61 VLRHCKKRQSHLRLTLKNNVFLFIDKLSYRDAKQLNMFLDIIHQNKSQQPMK----SDDD 116
Query: 121 GAILGSRTSQKETSRQLSYSD-NQASAKRGSLETKDDIPFRKVLGNPGRGSIKTVAGSGI 179
++ SR KE + YS N+ S ++ L
Sbjct: 117 WSVFESRNMLKEIDKTSFYSICNKPSYQKMPL---------------------------- 148
Query: 180 ARTIPSLTSTSTPLRSGLLENRTEKRKRMISTGSELNEDYPKENDSSSNNKAMTDPSRKY 239
++ + T ++ G+LEN+ K + +S+ + NED KE++ N K TD S KY
Sbjct: 149 -----FMSKSPTHVKKGILENQGGKGQNTLSSDVQTNEDILKEDNPVPNKKYKTD-SLKY 202
Query: 240 LTSSREKQLSLKQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGTNLDRTNVSSQTPSAK 299
+ S+R+ SL+ E++R L P SF + +G NLD T +++QT +AK
Sbjct: 203 IQSNRKNPSSLEDLEKDRDLKLGP----SF-------NTNCNGNPNLDETVLATQTLNAK 251
Query: 300 RSLGFLPQPVPLSVKKLRCNQDYTGWNKPRVPLSSHQQQQLQGFSNLGNTCYMNAILQSL 359
L +P S RCN K +VPL SH QQ QGF NLGNTCYMNA+LQSL
Sbjct: 252 NGLTSPLEPEH-SQGDPRCN-------KAQVPLDSHSQQLQQGFPNLGNTCYMNAVLQSL 303
Query: 360 FSLQSFANDLLKQGIPWKKIPLNALIRRFAHLLVKKDICNSETKKDLLKKVKNAISATAE 419
F++ SFA+DLL QG+PW+ IP ALI LL KD C+++ K++LL VK ISA AE
Sbjct: 304 FAIPSFADDLLTQGVPWEYIPFEALIMTLTQLLALKDFCSTKIKRELLGNVKKVISAVAE 363
Query: 420 RFSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTEPVSGEEN-SPDI----SATRAYTCP 474
FSG MQNDAHEFL QCLDQLKEDMEKLN T T G+EN SP + +AT+ + CP
Sbjct: 364 IFSGNMQNDAHEFLGQCLDQLKEDMEKLNATLNTGKECGDENSSPQMHVGSAATKVFVCP 423
Query: 475 VITNLEFEVQHSIICKACGEIIPKREQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEEL 534
V+ N EFE+Q S+ICKACG + K E N LSI+L + KPL P SIQ+SLDLFF+ EEL
Sbjct: 424 VVANFEFELQLSLICKACGHAVLKVEPNNYLSINLHQETKPL-PLSIQNSLDLFFKEEEL 482
Query: 535 EYSCEKCGGKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHC 594
EY+C+ C K + RH F+RL RVLI+HLKRYSFN A L K +QV IP+ L+LSS+C
Sbjct: 483 EYNCQMCKQKSCVARHTFSRLSRVLIIHLKRYSFNNAWLL-VKNNEQVYIPKSLSLSSYC 541
Query: 595 TENTKPPFTLGWSAHMAISRPLKASQMVNSCITSPSTPSKKFTFKSKSSLALCLDSDSED 654
E+TKPP L SA + L+ SQ + S I SP TPS K T +S SL L ++ D
Sbjct: 542 NESTKPPLPLSSSAPVGKCEVLEVSQEMISEINSPLTPSMKLTSESSDSLVLPVEPDKNA 601
Query: 655 ELKRSVALSQRLCEMLGNEQQQEDLEKDSKLCPIEPDKSELENSGFDRMSEEELLAAVLE 714
+L+R QR C EQ Q DLE S L +SEL + + E+EL A
Sbjct: 602 DLQR----FQRDCGDASQEQHQRDLENGSAL------ESELVHFRDRAIGEKELPVADSL 651
Query: 715 ISKRDASPSLSHEDDDKPTSSPDTGFAEDDIQEMPENPDTMETEKPKTITELDPASFTEI 774
+ + D S + +ED K SSPDT E +QE+P++P+ + EK T E + S TE
Sbjct: 652 MDQGDISLPVMYEDGGKLISSPDTRLVEVHLQEVPQHPELQKYEKTNTFVEFNFDSVTES 711
Query: 775 TKDCDENKENKTPEGSQGEVDWLQQYDMEREREEQELQQALAQSLQEQEAWEQKEDDDLK 834
T + KEN+ PEGSQG + LQQ +E ++ LQQA +++ +A E E + L
Sbjct: 712 TNGFYDCKENRIPEGSQGMAEQLQQC-IEESIIDEFLQQAPPPGVRKLDAQEHTE-ETLN 769
Query: 835 RATELSLQEFNNSFVDALGSDEDSGNEDVFDMEYTEAEAEELKRNAETGNLPHSYRLISV 894
++TEL LQ+ + + + ALGSD + GN+++ D E T EA+EL RN + G+ +YRLISV
Sbjct: 770 QSTELRLQKADLNHLGALGSD-NPGNKNILDAENTRGEAKELTRNVKMGDPLQAYRLISV 828
Query: 895 VSHIGSTSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEAAVQSDRDRSGYIFFYMHKEIF 954
VSHIGS+ +SGHYISDVYD +KQAWFTYNDL VS+I E +Q R SGYIFFYMH IF
Sbjct: 829 VSHIGSSPNSGHYISDVYDFQKQAWFTYNDLCVSEISETKMQEARLHSGYIFFYMHNGIF 888
Query: 955 DELLETEKNSQSLSTEVG 972
+ELL +NS+ ST+ G
Sbjct: 889 EELLRKAENSRLPSTQAG 906
>gi|13994268 ubiquitin-specific protease 26 [Homo sapiens]
Length = 913
Score = 623 bits (1606), Expect = e-178
Identities = 410/982 (41%), Positives = 565/982 (57%), Gaps = 75/982 (7%)
Query: 1 MSPLKIHGPIRIRSMQTGITKWKEGSFEIVEKENKVSLVVHYNTGGIPRIFQLSHNIKNV 60
M+ L + G ++I + +TGI+K KE E VE++ K LV+++ +G F+LS NI+NV
Sbjct: 1 MAALFLRGFVQIGNCKTGISKSKEAFIEAVERKKKDRLVLYFKSGKYST-FRLSDNIQNV 59
Query: 61 VLRPSGAKQSRLMLTLQDNSFLSIDKVPSKDAEEMRLFLDAVHQNRLPAAMKPSQGSGSF 120
VL+ Q+ L LTLQ+N+ L I+ + S DAE++++FLD VHQN + ++P +G F
Sbjct: 60 VLKSYRGNQNHLHLTLQNNNGLFIEGLSSTDAEQLKIFLDRVHQNEVQPPVRPGKGGSVF 119
Query: 121 GAILGSRTSQKETSRQLSYSDNQASAKRGSLETKDDIPFRKVLGNPGRGSIKTVAGSGIA 180
S T+QKE ++ + ++ S+ + I +G+G+
Sbjct: 120 -----SSTTQKEINKTSFHKVDEKSSSKSF-------------------EIAKGSGTGVL 155
Query: 181 RTIPSLTSTSTPLRSGLLENRTEKRKRMISTGSELNEDYPKENDSSSNNKAMTDPSRKYL 240
+ +P LTS T L EN+ +KRKRM+S+ SE+NE++ KEN+S K+ D SR +
Sbjct: 156 QRMPLLTSKLTLTCGELSENQHKKRKRMLSSSSEMNEEFLKENNSVEYKKSKADCSR-CV 214
Query: 241 TSSREKQLSLKQSEENRTSGLLPLQSSSFYGSRAGSKEHSSGGTNLDRTNVSSQTPSAKR 300
+ +REKQL LK+ EEN+ L +SS +++G LD + Q + K
Sbjct: 215 SYNREKQLKLKELEENKK---LECESSCIM--------NATGNPYLDDIGLL-QALTEKM 262
Query: 301 SLGFLPQPVPLSVKKLRCNQDYTGWNKPRVPLSSHQQQQLQGFSNLGNTCYMNAILQSLF 360
L FL Q + YT W+K ++ ++ G NLGNTCYMNA+LQSL
Sbjct: 263 VLVFLLQQ--------GYSDGYTKWDKLKLFFELFPEKICHGLPNLGNTCYMNAVLQSLL 314
Query: 361 SLQSFANDLLKQGIPWKKIPLNALIRRFAHLLVKKDICNSETKKDLLKKVKNAISATAER 420
S+ SFA+DLL Q PW KIPLNAL A LL KD N E K+ LL +K AISA AE
Sbjct: 315 SIPSFADDLLNQSFPWGKIPLNALTMCLARLLFFKDTYNIEIKEMLLLNLKKAISAAAEI 374
Query: 421 FSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTEPVSGEENSP-----DISATRAYTCPV 475
F G QNDAHEFL+ CLDQLK++MEKLN WK + GE+N P D T ++CPV
Sbjct: 375 FHGNAQNDAHEFLAHCLDQLKDNMEKLNTIWKPKSEFGEDNFPKQVFADDPDTSGFSCPV 434
Query: 476 ITNLEFEVQHSIICKACGEIIPKREQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELE 535
ITN E E+ HSI CKACG++I K E N LSI+LP+R K P SIQ + DLFF AEELE
Sbjct: 435 ITNFELELLHSIACKACGQVILKTELNNYLSINLPQRIK-AHPSSIQSTFDLFFGAEELE 493
Query: 536 YSCEKCGGKCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCT 595
Y C KC K ++ H F+RLPR+LI+HLKRYS N +L K Q+VII +YL +SSHC
Sbjct: 494 YKCAKCEHKTSVGVHSFSRLPRILIVHLKRYSLNEFCAL-KKNDQEVIISKYLKVSSHCN 552
Query: 596 ENTKPPFTLGWSAHMAISRPLKASQMVNSCITSPSTPSKKFTFKSKSSLALCLDSDSEDE 655
E T+PP L + + LK + + S S S P+ K +SK LA + SD E E
Sbjct: 553 EGTRPPLPLSEDGEITDFQLLKVIRKMTSGNISVSWPATK---ESKDILAPHIGSDKESE 609
Query: 656 LKRSVALSQRLCEMLGNEQQQEDLEKDSKLCPIEPDKSELENSGFDRMSEEELLAAVLEI 715
K+ Q + + QQQ+ L K+SK P++ E SG E+E LA ++
Sbjct: 610 QKK----GQTVFKGASRRQQQKYLGKNSK-----PNELESVYSGDRAFIEKEPLAHLMTY 660
Query: 716 SKRDASPSLSHEDDDKPTSSPDTGFAEDDIQEMPENPDTMETEKPKTITELDPASFTEIT 775
+ D S H+ KP SSP T ++ D Q +PENP + K D T
Sbjct: 661 LE-DTSLCQFHKAGGKPASSPGTPLSKVDFQTVPENPKRKKYVKTSKFVAFD--RIINPT 717
Query: 776 KDCDENKENKTPEGSQGEVDWLQQYDMEREREEQELQQALAQSLQEQEAWEQKEDDDLKR 835
KD E+K + PE Q + QQ D R EQ QQAL QS + Q +L R
Sbjct: 718 KDLYEDKNIRIPERFQKVSEQTQQCDGMRIC-EQAPQQALPQSFPKPGT--QGHTKNLLR 774
Query: 836 ATELSLQEFNNSFVDALGSDEDSGNEDVFDMEYTEAEAEELKRNAETGNLPHSYRLISVV 895
T+L+LQ+ N + + ALGS+++ N+D+ D +++A+E KRN + G+ H+YRLISVV
Sbjct: 775 PTKLNLQKSNRNSLLALGSNKNPRNKDILDK--IKSKAKETKRNDDKGD--HTYRLISVV 830
Query: 896 SHIGSTSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEAAVQSDRDRSGYIFFYMHKEIFD 955
SH+G T SGHYI D YD +KQ WFTY+D+ V IQEA +Q DR +GYIFFYMH EIF+
Sbjct: 831 SHLGKTLKSGHYICDAYDFEKQIWFTYDDMRVLGIQEAQMQEDRRCTGYIFFYMHNEIFE 890
Query: 956 ELLETEKNSQSLSTEVGKTTRQ 977
E+L+ E+N+Q S EV +T ++
Sbjct: 891 EMLKREENAQLNSKEVEETLQK 912
>gi|32698815 ubiquitin thiolesterase 12 [Homo sapiens]
Length = 370
Score = 92.8 bits (229), Expect = 1e-18
Identities = 81/271 (29%), Positives = 122/271 (45%), Gaps = 26/271 (9%)
Query: 342 GFSNLGNTCYMNAILQSLFSLQSFANDLLK-QGIPWKKIPLNALIRRFAHLLVKKDICNS 400
G N GNTCY N++LQ+L+ + F +L + P KK L + H I
Sbjct: 40 GLVNFGNTCYCNSVLQALYFCRPFREKVLAYKSQPRKKESLLTCLADLFH-----SIATQ 94
Query: 401 ETKKDLL--KKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTEPVSG 458
+ K ++ KK + E F YMQ DAHEFL+ L+ + + +++ K E +G
Sbjct: 95 KKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFLNYLLNTIADILQEERKQ---EKQNG 151
Query: 459 EENSPDISATRAYTCPVITNLEFEVQHSII----CKACGEIIPKREQFNDLSIDLPRRKK 514
+ +I + P T ++ Q ++ C C I K E F DLS+D+ +
Sbjct: 152 RLPNGNIDNENNNSTPDPTWVDEIFQGTLTNETRCLTCETISSKDEDFLDLSVDVEQNT- 210
Query: 515 PLPPRSIQDSLDLFFRAE----ELEYSCEKCGGKC-ALVRHKFNRLPRVLILHLKRYSFN 569
SI L F E E +Y CE+C K A R K +LP +L LHLKR+ +
Sbjct: 211 -----SITHCLRGFSNTETLCSEYKYYCEECRSKQEAHKRMKVKKLPMILALHLKRFKYM 265
Query: 570 VALSLNNKIGQQVIIPRYLTLSSHCTENTKP 600
L K+ +V+ P L L + + T P
Sbjct: 266 DQLHRYTKLSYRVVFPLELRLFNTSGDATNP 296
Score = 45.1 bits (105), Expect = 3e-04
Identities = 69/325 (21%), Positives = 129/325 (39%), Gaps = 40/325 (12%)
Query: 639 KSKSSLALCLDSDSEDELKRSVALSQRLCEMLGNEQQQEDLEKDSKLCP--IEPDKSELE 696
+ K SL CL +L S+A ++ ++ ++ L K+++L ++ D E
Sbjct: 75 RKKESLLTCLA-----DLFHSIATQKKKVGVIPPKKFITRLRKENELFDNYMQQDAHEFL 129
Query: 697 NSGFDRMSEEELLAAVLEISKRDASPSLSHEDDDKPTSSPDTGFAEDDIQEMPENPDTME 756
N + +++ +L + K++ + D++ S+PD + ++ Q N
Sbjct: 130 NYLLNTIAD--ILQEERKQEKQNGRLPNGNIDNENNNSTPDPTWVDEIFQGTLTNETRCL 187
Query: 757 TEKPKTITELDPASFTEITKDCDENKENKTPEGSQGEVDWLQQYDMEREREEQELQQALA 816
T +TI+ D F +++ D ++N + + E E +
Sbjct: 188 T--CETISSKDE-DFLDLSVDVEQNTS----------ITHCLRGFSNTETLCSEYKYYCE 234
Query: 817 QSLQEQEAWEQKEDDDLKRATELSLQEFNNSFVDALGSDEDSGNEDVFDMEYTEAEAEEL 876
+ +QEA ++ + L L L+ F ++D L VF +E
Sbjct: 235 ECRSKQEAHKRMKVKKLPMILALHLKRFK--YMDQLHRYTKLSYRVVFPLEL-----RLF 287
Query: 877 KRNAETGNLPHSYRLISVVSHIGSTSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEAAVQ 936
+ + N Y L++VV H GS + GHYI+ V W ++D V KI A++
Sbjct: 288 NTSGDATNPDRMYDLVAVVVHCGSGPNRGHYIAIVK--SHDFWLLFDDDIVEKIDAQAIE 345
Query: 937 ---------SDRDRSGYIFFYMHKE 952
S SGYI FY ++
Sbjct: 346 EFYGLTSDISKNSESGYILFYQSRD 370
>gi|197116355 ubiquitin specific peptidase 46 isoform 2 [Homo
sapiens]
Length = 359
Score = 88.6 bits (218), Expect = 3e-17
Identities = 74/262 (28%), Positives = 115/262 (43%), Gaps = 28/262 (10%)
Query: 342 GFSNLGNTCYMNAILQSLFSLQSFANDLLKQGIPWKKIPLNALIRRFAHLLVKKDICNSE 401
G N GNTCY N++LQ+L+ + F ++L KK L+ A L I +
Sbjct: 29 GLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQKK--KENLLTCLADLF--HSIATQK 84
Query: 402 TKKDLL--KKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWK------- 452
K ++ KK + + + F YMQ DAHEFL+ L+ + + +++ K K
Sbjct: 85 KKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGKLKN 144
Query: 453 ---TEPVSGEENSPDISATRAYTCPVITNLEFEVQHSIICKACGEIIPKREQFNDLSIDL 509
EP E N P+++ +TN C C + K E F DLS+D+
Sbjct: 145 GNMNEP--AENNKPELTWVHEIFQGTLTN-------ETRCLNCETVSSKDEDFLDLSVDV 195
Query: 510 PRRKKPLPPRSIQDSLDLFFRAEELEYSCEKCGGKC-ALVRHKFNRLPRVLILHLKRYSF 568
+ ++D + E +Y CE C K A R + +LP +L LHLKR+ +
Sbjct: 196 EQNTS--ITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKY 253
Query: 569 NVALSLNNKIGQQVIIPRYLTL 590
L K+ +V+ P L L
Sbjct: 254 MEQLHRYTKLSYRVVFPLELRL 275
Score = 45.1 bits (105), Expect = 3e-04
Identities = 28/83 (33%), Positives = 40/83 (48%), Gaps = 11/83 (13%)
Query: 879 NAETGNLPHSYRLISVVSHIGSTSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEAAVQ-- 936
+++ NL Y L++VV H GS + GHYI+ V W ++D V KI A++
Sbjct: 279 SSDAVNLDRMYDLVAVVVHCGSGPNRGHYITIVK--SHGFWLLFDDDIVEKIDAQAIEEF 336
Query: 937 -------SDRDRSGYIFFYMHKE 952
S SGYI FY +E
Sbjct: 337 YGLTSDISKNSESGYILFYQSRE 359
>gi|31377709 ubiquitin specific peptidase 46 isoform 1 [Homo
sapiens]
Length = 366
Score = 88.6 bits (218), Expect = 3e-17
Identities = 74/262 (28%), Positives = 115/262 (43%), Gaps = 28/262 (10%)
Query: 342 GFSNLGNTCYMNAILQSLFSLQSFANDLLKQGIPWKKIPLNALIRRFAHLLVKKDICNSE 401
G N GNTCY N++LQ+L+ + F ++L KK L+ A L I +
Sbjct: 36 GLVNFGNTCYCNSVLQALYFCRPFRENVLAYKAQQKK--KENLLTCLADLF--HSIATQK 91
Query: 402 TKKDLL--KKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWK------- 452
K ++ KK + + + F YMQ DAHEFL+ L+ + + +++ K K
Sbjct: 92 KKVGVIPPKKFISRLRKENDLFDNYMQQDAHEFLNYLLNTIADILQEEKKQEKQNGKLKN 151
Query: 453 ---TEPVSGEENSPDISATRAYTCPVITNLEFEVQHSIICKACGEIIPKREQFNDLSIDL 509
EP E N P+++ +TN C C + K E F DLS+D+
Sbjct: 152 GNMNEP--AENNKPELTWVHEIFQGTLTN-------ETRCLNCETVSSKDEDFLDLSVDV 202
Query: 510 PRRKKPLPPRSIQDSLDLFFRAEELEYSCEKCGGKC-ALVRHKFNRLPRVLILHLKRYSF 568
+ ++D + E +Y CE C K A R + +LP +L LHLKR+ +
Sbjct: 203 EQNTS--ITHCLRDFSNTETLCSEQKYYCETCCSKQEAQKRMRVKKLPMILALHLKRFKY 260
Query: 569 NVALSLNNKIGQQVIIPRYLTL 590
L K+ +V+ P L L
Sbjct: 261 MEQLHRYTKLSYRVVFPLELRL 282
Score = 45.1 bits (105), Expect = 3e-04
Identities = 28/83 (33%), Positives = 40/83 (48%), Gaps = 11/83 (13%)
Query: 879 NAETGNLPHSYRLISVVSHIGSTSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEAAVQ-- 936
+++ NL Y L++VV H GS + GHYI+ V W ++D V KI A++
Sbjct: 286 SSDAVNLDRMYDLVAVVVHCGSGPNRGHYITIVK--SHGFWLLFDDDIVEKIDAQAIEEF 343
Query: 937 -------SDRDRSGYIFFYMHKE 952
S SGYI FY +E
Sbjct: 344 YGLTSDISKNSESGYILFYQSRE 366
>gi|188528692 ubiquitin specific peptidase 2 isoform a [Homo
sapiens]
Length = 605
Score = 87.4 bits (215), Expect = 6e-17
Identities = 82/287 (28%), Positives = 132/287 (45%), Gaps = 28/287 (9%)
Query: 332 LSSHQQQQLQGFSNLGNTCYMNAILQSLFSLQSFANDLLK----QGIPWKKIPLNALIRR 387
++S Q L G NLGNTC+MN+ILQ L + + + L+ + + AL+
Sbjct: 258 MNSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEE 317
Query: 388 FAHLLVKKDICNSETKKDLL--KKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDME 445
FA L+ + + D++ + K I A RF GY Q DA EFL LD L ++
Sbjct: 318 FAKLI---QTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVN 374
Query: 446 KLNKTWKTEPVSGEENSPDISATRAYTCPVITNLEF--------EVQHSIICKACGEIIP 497
++ K+ P ++ PD R + + +++ S+ C CG
Sbjct: 375 RVTLRPKSNP-ENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCST 433
Query: 498 KREQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELE----YSCEKC-GGKCALVRHKF 552
+ F DLS LP K+ P ++ D + LF + + L+ +C +C G K + +
Sbjct: 434 VFDPFWDLS--LPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSI 491
Query: 553 NRLPRVLILHLKRYSFNVALSLNNKIGQQVIIP-RYLTLSSHCTENT 598
R P++L+LHLKR F+ + +K+ V P R L L +ENT
Sbjct: 492 QRFPKILVLHLKR--FSESRIRTSKLTTFVNFPLRDLDLREFASENT 536
Score = 33.1 bits (74), Expect = 1.3
Identities = 22/72 (30%), Positives = 33/72 (45%), Gaps = 5/72 (6%)
Query: 878 RNAETGNLPHS-YRLISVVSHIGSTSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEAAVQ 936
R + N H+ Y L +V +H G+T GHY + W T+ND V+ + + V
Sbjct: 529 REFASENTNHAVYNLYAVSNHSGTTMG-GHYTAYCRSPGTGEWHTFNDSSVTPMSSSQV- 586
Query: 937 SDRDRSGYIFFY 948
R Y+ FY
Sbjct: 587 --RTSDAYLLFY 596
>gi|28565285 ubiquitin specific peptidase 2 isoform b [Homo sapiens]
Length = 396
Score = 86.7 bits (213), Expect = 1e-16
Identities = 82/286 (28%), Positives = 131/286 (45%), Gaps = 28/286 (9%)
Query: 333 SSHQQQQLQGFSNLGNTCYMNAILQSLFSLQSFANDLLK----QGIPWKKIPLNALIRRF 388
+S Q L G NLGNTC+MN+ILQ L + + + L+ + + AL+ F
Sbjct: 50 NSKSAQGLAGLRNLGNTCFMNSILQCLSNTRELRDYCLQRLYMRDLHHGSNAHTALVEEF 109
Query: 389 AHLLVKKDICNSETKKDLL--KKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEK 446
A L+ + + D++ + K I A RF GY Q DA EFL LD L ++ +
Sbjct: 110 AKLI---QTIWTSSPNDVVSPSEFKTQIQRYAPRFVGYNQQDAQEFLRFLLDGLHNEVNR 166
Query: 447 LNKTWKTEPVSGEENSPDISATRAYTCPVITNLEF--------EVQHSIICKACGEIIPK 498
+ K+ P ++ PD R + + +++ S+ C CG
Sbjct: 167 VTLRPKSNP-ENLDHLPDDEKGRQMWRKYLEREDSRIGDLFVGQLKSSLTCTDCGYCSTV 225
Query: 499 REQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELE----YSCEKC-GGKCALVRHKFN 553
+ F DLS LP K+ P ++ D + LF + + L+ +C +C G K + +
Sbjct: 226 FDPFWDLS--LPIAKRGYPEVTLMDCMRLFTKEDVLDGDEKPTCCRCRGRKRCIKKFSIQ 283
Query: 554 RLPRVLILHLKRYSFNVALSLNNKIGQQVIIP-RYLTLSSHCTENT 598
R P++L+LHLKR F+ + +K+ V P R L L +ENT
Sbjct: 284 RFPKILVLHLKR--FSESRIRTSKLTTFVNFPLRDLDLREFASENT 327
Score = 33.1 bits (74), Expect = 1.3
Identities = 22/72 (30%), Positives = 33/72 (45%), Gaps = 5/72 (6%)
Query: 878 RNAETGNLPHS-YRLISVVSHIGSTSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEAAVQ 936
R + N H+ Y L +V +H G+T GHY + W T+ND V+ + + V
Sbjct: 320 REFASENTNHAVYNLYAVSNHSGTTMG-GHYTAYCRSPGTGEWHTFNDSSVTPMSSSQV- 377
Query: 937 SDRDRSGYIFFY 948
R Y+ FY
Sbjct: 378 --RTSDAYLLFY 387
>gi|55770886 ubiquitin thiolesterase 3 [Homo sapiens]
Length = 520
Score = 80.9 bits (198), Expect = 5e-15
Identities = 84/287 (29%), Positives = 123/287 (42%), Gaps = 58/287 (20%)
Query: 342 GFSNLGNTCYMNAILQSLFSLQSFANDLLKQGIPWKKIPLNALI------RRFAHLLVKK 395
G NLGNTC+MNAILQSL +++ F +K++P L RR H +
Sbjct: 160 GLRNLGNTCFMNAILQSLSNIEQFC-------CYFKELPAVELRNGKTAGRRTYHTRSQG 212
Query: 396 DICNSETKKDLLKKVKNAI---SATA--------------ERFSGYMQNDAHEFLSQCLD 438
D N+ + + +K A+ S TA F GY Q DAHEF+ LD
Sbjct: 213 D--NNVSLVEEFRKTLCALWQGSQTAFSPESLFYVVWKIMPNFRGYQQQDAHEFMRYLLD 270
Query: 439 QLKEDME------KLNKTWKTEPVSGEENSPDISATRAYTCPVITNLEFEVQHSIICKAC 492
L +++ + + N I+ + + +Q+ + C C
Sbjct: 271 HLHLELQGGFNGVSRSAILQENSTLSASNKCCINGASTVVTAIFGGI---LQNEVNCLIC 327
Query: 493 GEIIPKREQFNDLSIDLP--------RRKKPLPPRSIQDSLDLFFRAEELE----YSCEK 540
G K + F DLS+D+P + ++ P S++D L F EEL+ Y C K
Sbjct: 328 GTESRKFDPFLDLSLDIPSQFRSKRSKNQENGPVCSLRDCLRSFTDLEELDETELYMCHK 387
Query: 541 CGGKCALVRHKF--NRLPRVLILHLKRYSFNVALSLNNKIGQQVIIP 585
C K + KF +LP+VL LHLKR F+ L NK+ V P
Sbjct: 388 CKKKQKSTK-KFWIQKLPKVLCLHLKR--FHWTAYLRNKVDTYVEFP 431
Score = 37.7 bits (86), Expect = 0.053
Identities = 23/64 (35%), Positives = 31/64 (48%), Gaps = 5/64 (7%)
Query: 889 YRLISVVSHIGSTSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEAAVQSDRDRSGYIFFY 948
Y L +VV H GS SGHY + Y + WF +ND V+ E V + YI FY
Sbjct: 454 YDLAAVVVHHGSGVGSGHYTA--YATHEGRWFHFNDSTVTLTDEETVVKAK---AYILFY 508
Query: 949 MHKE 952
+ +
Sbjct: 509 VEHQ 512
>gi|62243586 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 76.3 bits (186), Expect = 1e-13
Identities = 74/294 (25%), Positives = 124/294 (42%), Gaps = 40/294 (13%)
Query: 342 GFSNLGNTCYMNAILQSLFSLQSFANDLLKQGIPWKKIP----LNALIRRFAHL---LVK 394
G NLGNTC++NA+LQ L S + + L++ +++P L FA + L
Sbjct: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFR-QEVPGGGRAQELTEAFADVIGALWH 271
Query: 395 KDICNSETKKDLLKKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTE 454
D C + + + FSGY Q DA EFL +++L ++ + +
Sbjct: 272 PDSCEAVNPT----RFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPI 327
Query: 455 PVSGEENSPDISATRAYTCPVITN-----------LEFE-----------VQHSIICKAC 492
+G SP P +++ LE E ++ + C+AC
Sbjct: 328 LANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQAC 387
Query: 493 GEIIPKREQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELEYS----CEKCGGKCALV 548
G E F DLS+ +P++ S++D +LF + EELE C++C K
Sbjct: 388 GYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRST 447
Query: 549 RH-KFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTENTKPP 601
+ R PR+L+LHL R+S + + +G + R L+L ++ P
Sbjct: 448 KKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQR-LSLGDFASDKAGSP 500
>gi|74027267 ubiquitin-specific protease 21 [Homo sapiens]
Length = 565
Score = 76.3 bits (186), Expect = 1e-13
Identities = 74/294 (25%), Positives = 124/294 (42%), Gaps = 40/294 (13%)
Query: 342 GFSNLGNTCYMNAILQSLFSLQSFANDLLKQGIPWKKIP----LNALIRRFAHL---LVK 394
G NLGNTC++NA+LQ L S + + L++ +++P L FA + L
Sbjct: 213 GLRNLGNTCFLNAVLQCLSSTRPLRDFCLRRDFR-QEVPGGGRAQELTEAFADVIGALWH 271
Query: 395 KDICNSETKKDLLKKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTE 454
D C + + + FSGY Q DA EFL +++L ++ + +
Sbjct: 272 PDSCEAVNPT----RFRAVFQKYVPSFSGYSQQDAQEFLKLLMERLHLEINRRGRRAPPI 327
Query: 455 PVSGEENSPDISATRAYTCPVITN-----------LEFE-----------VQHSIICKAC 492
+G SP P +++ LE E ++ + C+AC
Sbjct: 328 LANGPVPSPPRRGGALLEEPELSDDDRANLMWKRYLEREDSKIVDLFVGQLKSCLKCQAC 387
Query: 493 GEIIPKREQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELEYS----CEKCGGKCALV 548
G E F DLS+ +P++ S++D +LF + EELE C++C K
Sbjct: 388 GYRSTTFEVFCDLSLPIPKKGFAGGKVSLRDCFNLFTKEEELESENAPVCDRCRQKTRST 447
Query: 549 RH-KFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTENTKPP 601
+ R PR+L+LHL R+S + + +G + R L+L ++ P
Sbjct: 448 KKLTVQRFPRILVLHLNRFSASRGSIKKSSVGVDFPLQR-LSLGDFASDKAGSP 500
>gi|190684694 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 73.9 bits (180), Expect = 7e-13
Identities = 64/251 (25%), Positives = 114/251 (45%), Gaps = 30/251 (11%)
Query: 340 LQGFSNLGNTCYMNAILQSL---------FSLQSFANDLLKQGIPWKKIPLNALIRRFAH 390
L G NLGNTCYMN+ILQ L F+ + +D+ + + K + F
Sbjct: 776 LTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHK---GEVAEEFG- 831
Query: 391 LLVKKDICNSETKKDLLKKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKT 450
++ K + + + K K I ++F+GY Q D+ E L +D L ED+ K +
Sbjct: 832 -IIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNR 890
Query: 451 WKTEPVSGEENSPDISATRAY-------TCPVITNLEFEVQHSIICKACGEIIPKREQFN 503
+ + + + +A A+ ++ + + + ++ C C + E F
Sbjct: 891 KRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFM 950
Query: 504 DLSIDLPRRKKPLPPRSIQDSLDLFFRAEEL----EYSCEKC-GGKCALVRHKFNRLPRV 558
LS+ L K ++QD L LF + E+L + C C + +L + + +LP V
Sbjct: 951 YLSLPLASTSK----CTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPV 1006
Query: 559 LILHLKRYSFN 569
L++HLKR+S++
Sbjct: 1007 LLVHLKRFSYD 1017
Score = 42.0 bits (97), Expect = 0.003
Identities = 23/60 (38%), Positives = 33/60 (55%), Gaps = 4/60 (6%)
Query: 889 YRLISVVSHIGSTSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEAAVQSDRDRSGYIFFY 948
Y L SV +H G GHY + + +Q WF ++D EVS I ++V+S + YI FY
Sbjct: 1051 YNLFSVSNHYGGLDG-GHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSS---AAYILFY 1106
>gi|190684692 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 73.9 bits (180), Expect = 7e-13
Identities = 64/251 (25%), Positives = 114/251 (45%), Gaps = 30/251 (11%)
Query: 340 LQGFSNLGNTCYMNAILQSL---------FSLQSFANDLLKQGIPWKKIPLNALIRRFAH 390
L G NLGNTCYMN+ILQ L F+ + +D+ + + K + F
Sbjct: 776 LTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHK---GEVAEEFG- 831
Query: 391 LLVKKDICNSETKKDLLKKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKT 450
++ K + + + K K I ++F+GY Q D+ E L +D L ED+ K +
Sbjct: 832 -IIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNR 890
Query: 451 WKTEPVSGEENSPDISATRAY-------TCPVITNLEFEVQHSIICKACGEIIPKREQFN 503
+ + + + +A A+ ++ + + + ++ C C + E F
Sbjct: 891 KRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFM 950
Query: 504 DLSIDLPRRKKPLPPRSIQDSLDLFFRAEEL----EYSCEKC-GGKCALVRHKFNRLPRV 558
LS+ L K ++QD L LF + E+L + C C + +L + + +LP V
Sbjct: 951 YLSLPLASTSK----CTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPV 1006
Query: 559 LILHLKRYSFN 569
L++HLKR+S++
Sbjct: 1007 LLVHLKRFSYD 1017
Score = 42.0 bits (97), Expect = 0.003
Identities = 23/60 (38%), Positives = 33/60 (55%), Gaps = 4/60 (6%)
Query: 889 YRLISVVSHIGSTSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEAAVQSDRDRSGYIFFY 948
Y L SV +H G GHY + + +Q WF ++D EVS I ++V+S + YI FY
Sbjct: 1051 YNLFSVSNHYGGLDG-GHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSS---AAYILFY 1106
>gi|190684690 ubiquitin specific peptidase 8 [Homo sapiens]
Length = 1118
Score = 73.9 bits (180), Expect = 7e-13
Identities = 64/251 (25%), Positives = 114/251 (45%), Gaps = 30/251 (11%)
Query: 340 LQGFSNLGNTCYMNAILQSL---------FSLQSFANDLLKQGIPWKKIPLNALIRRFAH 390
L G NLGNTCYMN+ILQ L F+ + +D+ + + K + F
Sbjct: 776 LTGLRNLGNTCYMNSILQCLCNAPHLADYFNRNCYQDDINRSNLLGHK---GEVAEEFG- 831
Query: 391 LLVKKDICNSETKKDLLKKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKT 450
++ K + + + K K I ++F+GY Q D+ E L +D L ED+ K +
Sbjct: 832 -IIMKALWTGQYRYISPKDFKITIGKINDQFAGYSQQDSQELLLFLMDGLHEDLNKADNR 890
Query: 451 WKTEPVSGEENSPDISATRAY-------TCPVITNLEFEVQHSIICKACGEIIPKREQFN 503
+ + + + +A A+ ++ + + + ++ C C + E F
Sbjct: 891 KRYKEENNDHLDDFKAAEHAWQKHKQLNESIIVALFQGQFKSTVQCLTCHKKSRTFEAFM 950
Query: 504 DLSIDLPRRKKPLPPRSIQDSLDLFFRAEEL----EYSCEKC-GGKCALVRHKFNRLPRV 558
LS+ L K ++QD L LF + E+L + C C + +L + + +LP V
Sbjct: 951 YLSLPLASTSK----CTLQDCLRLFSKEEKLTDNNRFYCSHCRARRDSLKKIEIWKLPPV 1006
Query: 559 LILHLKRYSFN 569
L++HLKR+S++
Sbjct: 1007 LLVHLKRFSYD 1017
Score = 42.0 bits (97), Expect = 0.003
Identities = 23/60 (38%), Positives = 33/60 (55%), Gaps = 4/60 (6%)
Query: 889 YRLISVVSHIGSTSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEAAVQSDRDRSGYIFFY 948
Y L SV +H G GHY + + +Q WF ++D EVS I ++V+S + YI FY
Sbjct: 1051 YNLFSVSNHYGGLDG-GHYTAYCKNAARQRWFKFDDHEVSDISVSSVKSS---AAYILFY 1106
>gi|57529246 ubiquitin thioesterase 19 [Homo sapiens]
Length = 1318
Score = 73.6 bits (179), Expect = 9e-13
Identities = 54/189 (28%), Positives = 92/189 (48%), Gaps = 15/189 (7%)
Query: 342 GFSNLGNTCYMNAILQSLFS---LQSFANDLLKQGIPWKKIPLNA---LIRRFAHLLVKK 395
G NLGNTC+MN+++QSL + L+ F +D + PL L FA LL +
Sbjct: 498 GLVNLGNTCFMNSVIQSLSNTRELRDFFHDRSFEAEINYNNPLGTGGRLAIGFAVLL--R 555
Query: 396 DICNSETKKDLLKKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTEP 455
+ K+K +++ A +F+GY Q+DA EF++ LD L ED+ ++ TE
Sbjct: 556 ALWKGTHHAFQPSKLKAIVASKASQFTGYAQHDAQEFMAFLLDGLHEDLNRIQNKPYTET 615
Query: 456 VSGEENSPDISATRAYTCPVITNLEF-------EVQHSIICKACGEIIPKREQFNDLSID 508
V + ++ A A+ + N F + + ++C C ++ + F L +
Sbjct: 616 VDSDGRPDEVVAEEAWQRHKMRNDSFIVDLFQGQYKSKLVCPVCAKVSITFDPFLYLPVP 675
Query: 509 LPRRKKPLP 517
LP+++K LP
Sbjct: 676 LPQKQKVLP 684
Score = 31.2 bits (69), Expect = 5.0
Identities = 29/81 (35%), Positives = 40/81 (49%), Gaps = 7/81 (8%)
Query: 520 SIQDSLDLFFRAEELE----YSCEKCGG-KCALVRHKFNRLPRVLILHLKRYSFNVALSL 574
++ L+LF R E L + C +C + A + RLP VLI+ LKR+SF +
Sbjct: 1059 TLDQCLNLFTRPEVLAPEEAWYCPQCKQHREASKQLLLWRLPNVLIVQLKRFSFR-SFIW 1117
Query: 575 NNKIGQQVIIP-RYLTLSSHC 594
+KI V P R L LS C
Sbjct: 1118 RDKINDLVEFPVRNLDLSKFC 1138
>gi|150010639 ubiquitin thiolesterase 22 [Homo sapiens]
Length = 525
Score = 71.6 bits (174), Expect = 3e-12
Identities = 73/291 (25%), Positives = 115/291 (39%), Gaps = 41/291 (14%)
Query: 326 NKPRVPLSSHQQQQLQGFSNLGNTCYMNAILQSLFSLQSFANDLLKQGIPWK-KIPLNAL 384
N R ++S+ L+G NLGNTC+MN I+Q+L + L + + P + L
Sbjct: 161 NPKRRKITSNCTIGLRGLINLGNTCFMNCIVQALTHTPLLRDFFLSDRHRCEMQSPSSCL 220
Query: 385 IRRFAHLLVKKDICNSETKKDLLKKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDM 444
+ + L ++ + + K+ + + A +GY Q DAHEFL LD L
Sbjct: 221 VCEMSSLF--QEFYSGHRSPHIPYKLLHLVWTHARHLAGYEQQDAHEFLIAALDVLHRHC 278
Query: 445 EKLNKTWKTEPVSGEENSPDISATRAYTCPVITNLEFEVQHSIICKACGEIIPKREQFND 504
+ G++N + C + +Q + C+ C + + F D
Sbjct: 279 K------------GDDNGKKANNPNHCNCIIDQIFTGGLQSDVTCQVCHGVSTTIDPFWD 326
Query: 505 LSIDLPRRKKPLPPRS-------------------IQDSLDLFFRAEELEYSCE-KCGG- 543
+S+DLP P P S + D L F R E L S + KC G
Sbjct: 327 ISLDLPGSSTPFWPLSPGSEGNVVNGESHVSGTTTLTDCLRRFTRPEHLGSSAKIKCSGC 386
Query: 544 ---KCALVRHKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLS 591
+ + + +LP V HLKR F + L KI V P L ++
Sbjct: 387 HSYQESTKQLTMKKLPIVACFHLKR--FEHSAKLRRKITTYVSFPLELDMT 435
>gi|45267835 ubiquitin specific protease 50 [Homo sapiens]
Length = 339
Score = 70.5 bits (171), Expect = 7e-12
Identities = 70/243 (28%), Positives = 114/243 (46%), Gaps = 23/243 (9%)
Query: 338 QQLQGFSNLGNTCYMNAILQSLFSLQSFANDLL--KQGIPWKKIPL----NALIRRFAHL 391
Q + G NLGNTC +NAI Q L S+ L K +K L + + FA+L
Sbjct: 41 QGVTGLWNLGNTCCVNAISQCLCSILPLVEYFLTGKYITALQKFLLPSDCSEVATAFAYL 100
Query: 392 LVKKDICNSETKKDLLKKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKTW 451
+ + +S+ + +A+ F+ MQ DA EFL L++L E ++K + +
Sbjct: 101 MTDMWLGDSDCVSPEI--FWSALGNLYPAFTKKMQQDAQEFLICVLNELHEALKKYHYSR 158
Query: 452 KTEPVSGEENSPDISATRAYT--CPVITNL-EFEVQHSIICKACGEIIPKREQFNDLSID 508
+ S E+ S + T +IT L E ++ +SI+C C + K E F S+
Sbjct: 159 RR---SYEKGSTQRCCRKWITTETSIITQLFEEQLNYSIVCLKCEKCTYKNEVFTVFSLP 215
Query: 509 LPRRKKPLPPRSIQDSLDLFFRAEEL----EYSCEKCGGKC-ALVRHKFNRLPRVLILHL 563
+P + + S++D L FF+ + L E C C K VR ++ P+++I HL
Sbjct: 216 IPSKYE----CSLRDCLQCFFQQDALTWNNEIHCSFCETKQETAVRASISKAPKIIIFHL 271
Query: 564 KRY 566
KR+
Sbjct: 272 KRF 274
>gi|40795665 ubiquitin specific protease 4 isoform a [Homo sapiens]
Length = 963
Score = 65.9 bits (159), Expect = 2e-10
Identities = 55/203 (27%), Positives = 87/203 (42%), Gaps = 29/203 (14%)
Query: 331 PLSSHQQQQLQGFSNLGNTCYMNAILQSLFSLQSFANDLLKQGIPWKKIPLNALIRRFAH 390
P SSH Q L G NLGNTC+MN+ LQ L + + LK A I R
Sbjct: 292 PPSSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKD-------EYEAEINRDNP 344
Query: 391 LLVKKDICNSETKKDLLKKV-------------KNAISATAERFSGYMQNDAHEFLSQCL 437
L +K +I +E +L+K++ K + A +FSGY Q D+ E L+ L
Sbjct: 345 LGMKGEI--AEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLL 402
Query: 438 DQLKEDMEKLNKTWKTEPVSGEENSPDISATRAY-------TCPVITNLEFEVQHSIICK 490
D L ED+ ++ K E + A A+ ++ + +++C
Sbjct: 403 DGLHEDLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCP 462
Query: 491 ACGEIIPKREQFNDLSIDLPRRK 513
C ++ + F L++ LP +K
Sbjct: 463 ECAKVSVTFDPFCYLTLPLPLKK 485
Score = 33.5 bits (75), Expect = 1.0
Identities = 22/67 (32%), Positives = 36/67 (53%), Gaps = 7/67 (10%)
Query: 509 LPRRKKPLPPRSIQDSLDLFFRAEEL----EYSCEKCGGKCALVRHKFN--RLPRVLILH 562
L +KK +++D ++LF E L + C C K KF+ LP++L++H
Sbjct: 766 LQPQKKKKTTVALRDCIELFTTMETLGEHDPWYCPNCK-KHQQATKKFDLWSLPKILVVH 824
Query: 563 LKRYSFN 569
LKR+S+N
Sbjct: 825 LKRFSYN 831
>gi|40795667 ubiquitin specific protease 4 isoform b [Homo sapiens]
Length = 916
Score = 65.9 bits (159), Expect = 2e-10
Identities = 55/203 (27%), Positives = 87/203 (42%), Gaps = 29/203 (14%)
Query: 331 PLSSHQQQQLQGFSNLGNTCYMNAILQSLFSLQSFANDLLKQGIPWKKIPLNALIRRFAH 390
P SSH Q L G NLGNTC+MN+ LQ L + + LK A I R
Sbjct: 245 PPSSHIQPGLCGLGNLGNTCFMNSALQCLSNTAPLTDYFLKD-------EYEAEINRDNP 297
Query: 391 LLVKKDICNSETKKDLLKKV-------------KNAISATAERFSGYMQNDAHEFLSQCL 437
L +K +I +E +L+K++ K + A +FSGY Q D+ E L+ L
Sbjct: 298 LGMKGEI--AEAYAELIKQMWSGRDAHVAPRMFKTQVGRFAPQFSGYQQQDSQELLAFLL 355
Query: 438 DQLKEDMEKLNKTWKTEPVSGEENSPDISATRAY-------TCPVITNLEFEVQHSIICK 490
D L ED+ ++ K E + A A+ ++ + +++C
Sbjct: 356 DGLHEDLNRVKKKPYLELKDANGRPDAVVAKEAWENHRLRNDSVIVDTFHGLFKSTLVCP 415
Query: 491 ACGEIIPKREQFNDLSIDLPRRK 513
C ++ + F L++ LP +K
Sbjct: 416 ECAKVSVTFDPFCYLTLPLPLKK 438
Score = 33.5 bits (75), Expect = 1.0
Identities = 22/67 (32%), Positives = 36/67 (53%), Gaps = 7/67 (10%)
Query: 509 LPRRKKPLPPRSIQDSLDLFFRAEEL----EYSCEKCGGKCALVRHKFN--RLPRVLILH 562
L +KK +++D ++LF E L + C C K KF+ LP++L++H
Sbjct: 719 LQPQKKKKTTVALRDCIELFTTMETLGEHDPWYCPNCK-KHQQATKKFDLWSLPKILVVH 777
Query: 563 LKRYSFN 569
LKR+S+N
Sbjct: 778 LKRFSYN 784
>gi|14149627 ubiquitin specific peptidase 15 [Homo sapiens]
Length = 952
Score = 65.5 bits (158), Expect = 2e-10
Identities = 60/234 (25%), Positives = 103/234 (44%), Gaps = 29/234 (12%)
Query: 295 TPSAKRSLGFLPQPVPLSVKKLRCNQDYTGWNKPRVPLSSHQQQQLQGFSNLGNTCYMNA 354
TP+ K S LP N DY+ P +++Q L G SNLGNTC+MN+
Sbjct: 226 TPNVKNSNYCLPSYTAYK------NYDYSE------PGRNNEQPGLCGLSNLGNTCFMNS 273
Query: 355 ILQSLFSL----QSFANDLLKQGIPWKKIPLNA---LIRRFAHLLVKKDICNSETKKDLL 407
+Q L + + F ND ++ + + PL + + +A L+ K + + +
Sbjct: 274 AIQCLSNTPPLTEYFLNDKYQEELNFDN-PLGMRGEIAKSYAELI--KQMWSGKFSYVTP 330
Query: 408 KKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTEPVSGEENSPDISA 467
+ K + A +FSGY Q D E L+ LD L ED+ ++ K + + + A
Sbjct: 331 RAFKTQVGRFAPQFSGYQQQDCQELLAFLLDGLHEDLNRIRKKPYIQLKDADGRPDKVVA 390
Query: 468 TRAYTCPVITNLEFEV-------QHSIICKACGEIIPKREQFNDLSIDLPRRKK 514
A+ + N V + +++C C +I + F L++ LP +K+
Sbjct: 391 EEAWENHLKRNDSIIVDIFHGLFKSTLVCPECAKISVTFDPFCYLTLPLPMKKE 444
Score = 38.9 bits (89), Expect = 0.024
Identities = 24/94 (25%), Positives = 41/94 (43%), Gaps = 6/94 (6%)
Query: 861 EDVFDMEYTEAEAEELKRNAETGNLPHSYRLISVVSHIGSTSSSGHYISDVYDIKKQAWF 920
+ + D + + E N G P Y LI+V +H G GHY + + W+
Sbjct: 820 DTLVDFPINDLDMSEFLINPNAG--PCRYNLIAVSNHYGGMGG-GHYTAFAKNKDDGKWY 876
Query: 921 TYNDLEVSKIQEAAVQSDRDRSGYIFFYMHKEIF 954
++D VS E + S ++ Y+ FY ++ F
Sbjct: 877 YFDDSSVSTASEDQIVS---KAAYVLFYQRQDTF 907
>gi|223005906 X-linked ubiquitin thioesterase 27 [Homo sapiens]
Length = 438
Score = 64.7 bits (156), Expect = 4e-10
Identities = 71/272 (26%), Positives = 109/272 (40%), Gaps = 48/272 (17%)
Query: 324 GWNKPRVPLSSHQQQQLQGFSNLGNTCYMNAILQSL----FSLQSFANDLLKQGIPWKKI 379
G N R ++S L+G NLGNTC+MN I+Q+L F +D + +P
Sbjct: 61 GHNPRRRRITSSFTIGLRGLINLGNTCFMNCIVQALTHTPILRDFFLSDRHRCEMP---S 117
Query: 380 PLNALIRRFAHLLVKKDICNSETKKDLLKKVKNAISATAERFSGYMQNDAHEFLSQCLDQ 439
P L+ + L +++ + + K+ + + A +GY Q DAHEFL LD
Sbjct: 118 PELCLVCEMSSLF--RELYSGNPSPHVPYKLLHLVWIHARHLAGYRQQDAHEFLIAALD- 174
Query: 440 LKEDMEKLNKTWKTEPVSGEENSPDISATRAYTCPVITNLEFE--VQHSIICKACGEIIP 497
L++ K + V N+P+ C I + F +Q + C+AC +
Sbjct: 175 ------VLHRHCKGDDVGKAANNPN-------HCNCIIDQIFTGGLQSDVTCQACHGVST 221
Query: 498 KREQFNDLSIDLPRRKKPLPPRS------------------IQDSLDLFFRAEELEYSCE 539
+ D+S+DLP P S + D L F R E L S +
Sbjct: 222 TIDPCWDISLDLPGSCTSFWPMSPGRESSVNGESHIPGITTLTDCLRRFTRPEHLGSSAK 281
Query: 540 KCGGKCALVRHK-----FNRLPRVLILHLKRY 566
G C + N+LP V H KR+
Sbjct: 282 IKCGSCQSYQESTKQLTMNKLPVVACFHFKRF 313
Score = 49.3 bits (116), Expect = 2e-05
Identities = 36/104 (34%), Positives = 56/104 (53%), Gaps = 14/104 (13%)
Query: 865 DMEYTEAEAEELKRNAE------TGNLPHSYRLISVVSHIGSTSSSGHYISDVYDIKKQA 918
DM A ++E + N + +GN + Y L +VV+H G T SGHY S + K Q
Sbjct: 334 DMTPFMASSKESRMNGQLQLPTNSGNNENKYSLFAVVNHQG-TLESGHYTSFIRHHKDQ- 391
Query: 919 WFTYNDLEVSKIQEAAVQSDRDRSGYIFFYMHKEIFDELLETEK 962
WF +D ++K A+++ D GY+ FY HK++ + E+EK
Sbjct: 392 WFKCDDAVITK---ASIKDVLDSEGYLLFY-HKQVLEH--ESEK 429
>gi|149192845 ubiquitin specific protease 24 [Homo sapiens]
Length = 2460
Score = 62.8 bits (151), Expect = 2e-09
Identities = 70/274 (25%), Positives = 107/274 (39%), Gaps = 48/274 (17%)
Query: 331 PLSSHQQQQLQGFSNLGNTCYMNAILQSLFSLQSFANDLLKQGIPWKKIPLNALIRR--- 387
P+ S G N G TCYMNA+ Q L+ LL P +++ +
Sbjct: 1519 PVDSRSSSGFVGLRNGGATCYMNAVFQQLYMQPGLPESLLSVDDDTDN-PDDSVFYQVQS 1577
Query: 388 -FAHLLVKKDICNSETKKDLLKKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEK 446
F HL+ K + K+ N E Q DA+EF + +DQ+ E ++K
Sbjct: 1578 LFGHLMESKLQYYVPENFWKIFKMWNKELYVRE------QQDAYEFFTSLIDQMDEYLKK 1631
Query: 447 LNKTWKTEPVSGEENSPDISATRAYTCPVITNLEFEVQHSI--ICKACGEIIPKREQFND 504
+ + I F+ +S ICK C + E F
Sbjct: 1632 MGRDQ------------------------IFKNTFQGIYSDQKICKDCPHRYEREEAFMA 1667
Query: 505 LSIDLPRRKKPLPPRSIQDSLDLFFRAEELE----YSCEKCGGKCALVRHK-FNRLPRVL 559
L++ + + S++ SLD F R E LE Y CEKC K V+ LP VL
Sbjct: 1668 LNLGVTSCQ------SLEISLDQFVRGEVLEGSNAYYCEKCKEKRITVKRTCIKSLPSVL 1721
Query: 560 ILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSH 593
++HL R+ F+ + K +Q+ P L + +
Sbjct: 1722 VIHLMRFGFDWESGRSIKYDEQIRFPWMLNMEPY 1755
Score = 30.8 bits (68), Expect = 6.5
Identities = 15/48 (31%), Positives = 26/48 (54%), Gaps = 4/48 (8%)
Query: 885 LPHSYRLISVVSHIGSTSSSGHYISDVYDIK---KQAWFTYNDLEVSK 929
L +Y L+ V+ H G + +GHY S + D + K W+ +ND + +
Sbjct: 1790 LTENYELVGVIVHSGQ-AHAGHYYSFIKDRRGCGKGKWYKFNDTVIEE 1836
>gi|22550104 ubiquitin specific protease 32 [Homo sapiens]
Length = 1604
Score = 61.6 bits (148), Expect = 3e-09
Identities = 48/181 (26%), Positives = 84/181 (46%), Gaps = 13/181 (7%)
Query: 342 GFSNLGNTCYMNAILQSLFSLQSFANDLLKQGIPWKKIPLNALIRRFAHLLVKKDICN-- 399
G SNLGNTC+MN+ +Q + + Q + ++ N + + D+
Sbjct: 735 GLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQEL 794
Query: 400 -SETKKDLLK-KVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTEPVS 457
S T+K++ K++ I+ A RF+G+ Q D+ E L+ LD L ED+ ++++ E +
Sbjct: 795 WSGTQKNVAPLKLRWTIAKYAPRFNGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVE-LK 853
Query: 458 GEENSPDISAT--------RAYTCPVITNLEFEVQHSIICKACGEIIPKREQFNDLSIDL 509
+ PD R V+ +++ + CK CG I + + FN LS+ L
Sbjct: 854 DSDGRPDWEVAAEAWDNHLRRNRSIVVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPL 913
Query: 510 P 510
P
Sbjct: 914 P 914
Score = 36.2 bits (82), Expect = 0.15
Identities = 24/63 (38%), Positives = 31/63 (49%), Gaps = 7/63 (11%)
Query: 512 RKKPLPPRSIQDSLDLFFRAEELE----YSCEKCGGKCALVRHKFN--RLPRVLILHLKR 565
R+ P ++ L F EEL Y C KC C L K + RLP +LI+HLKR
Sbjct: 1226 RRAQAEPINLDSCLRAFTSEEELGENEMYYCSKCKTHC-LATKKLDLWRLPPILIIHLKR 1284
Query: 566 YSF 568
+ F
Sbjct: 1285 FQF 1287
>gi|109638751 ubiquitin specific protease 6 [Homo sapiens]
Length = 1406
Score = 60.8 bits (146), Expect = 6e-09
Identities = 46/181 (25%), Positives = 82/181 (45%), Gaps = 13/181 (7%)
Query: 342 GFSNLGNTCYMNAILQSLFSLQSFANDLLKQGIPWKKIPLNALIRRFAHLLVKKDICN-- 399
G SNLGNTC+MN+ +Q + + Q + ++ N + + D+
Sbjct: 533 GLSNLGNTCFMNSSIQCVSNTQPLTQYFISGRHLYELNRTNPIGMKGHMAKCYGDLVQEL 592
Query: 400 -SETKKDLLK-KVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTEPVS 457
S T+K + K++ I+ A +F G+ Q D+ E L+ LD L ED+ ++++ E +
Sbjct: 593 WSGTQKSVAPLKLRRTIAKYAPKFDGFQQQDSQELLAFLLDGLHEDLNRVHEKPYVE-LK 651
Query: 458 GEENSPDISAT--------RAYTCPVITNLEFEVQHSIICKACGEIIPKREQFNDLSIDL 509
+ PD R ++ +++ + CK CG I + + FN LS+ L
Sbjct: 652 DSDGRPDWEVAAEAWDNHLRRNRSIIVDLFHGQLRSQVKCKTCGHISVRFDPFNFLSLPL 711
Query: 510 P 510
P
Sbjct: 712 P 712
Score = 34.7 bits (78), Expect = 0.45
Identities = 24/63 (38%), Positives = 30/63 (47%), Gaps = 7/63 (11%)
Query: 512 RKKPLPPRSIQDSLDLFFRAEELE----YSCEKCGGKCALVRHKFN--RLPRVLILHLKR 565
R+ P ++ L F EEL Y C KC C L K + RLP LI+HLKR
Sbjct: 1024 RRAQAEPINLDSCLRAFTSEEELGESEMYYCSKCKTHC-LATKKLDLWRLPPFLIIHLKR 1082
Query: 566 YSF 568
+ F
Sbjct: 1083 FQF 1085
>gi|41152235 ubiquitin specific protease 51 [Homo sapiens]
Length = 711
Score = 60.8 bits (146), Expect = 6e-09
Identities = 66/255 (25%), Positives = 100/255 (39%), Gaps = 45/255 (17%)
Query: 340 LQGFSNLGNTCYMNAILQSLFSL----QSFANDLLKQGIPWKKIPLNALIRRFAHLLVKK 395
L+G NLGNTC+MN I+Q+L + F +D K + + L + H +
Sbjct: 362 LRGLINLGNTCFMNCIVQALTHIPLLKDFFLSDKHKCIMTSPSLCLVCEMSSLFHAMY-- 419
Query: 396 DICNSETKKDLLKKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWKTEP 455
+ + K+ + I AE +GY Q DAHEFL LD L++ K +
Sbjct: 420 ---SGSRTPHIPYKLLHLIWIHAEHLAGYRQQDAHEFLIAILD-------VLHRHSKDDS 469
Query: 456 VSGEENSPDISATRAYTCPVITNLEFEVQHSIICKACGEIIPKREQFNDLSIDLP----- 510
E N+P+ C + +Q + C+AC + + D+S+DLP
Sbjct: 470 GGQEANNPN-----CCNCIIDQIFTGGLQSDVTCQACHSVSTTIDPCWDISLDLPGSCAT 524
Query: 511 -------------RRKKPLPP-RSIQDSLDLFFRAEEL----EYSCEKCGGKCALVRH-K 551
R +P S+ D L F R E L + C C +
Sbjct: 525 FDSQNPERADSTVSRDDHIPGIPSLTDCLQWFTRPEHLGSSAKIKCNSCQSYQESTKQLT 584
Query: 552 FNRLPRVLILHLKRY 566
+LP V HLKR+
Sbjct: 585 MKKLPIVACFHLKRF 599
>gi|50312666 ubiquitin specific peptidase 25 [Homo sapiens]
Length = 1055
Score = 59.3 bits (142), Expect = 2e-08
Identities = 69/288 (23%), Positives = 109/288 (37%), Gaps = 46/288 (15%)
Query: 325 WNKPRVPLSSHQQQQLQ-GFSNLGNTCYMNAILQSLFSLQSF------------ANDLLK 371
W R P +Q + G N+GNTC+ +A++QSLF+L F A DL +
Sbjct: 152 WRDSRNPYDRKRQDKAPVGLKNVGNTCWFSAVIQSLFNLLEFRRLVLNYKPPSNAQDLPR 211
Query: 372 QGIPWKKIPLNALIRRFAHLLV--KKDICNSETKKDLLKKVKNAISATAERFSGYMQNDA 429
+ +P +R LLV K+ + ++LK A + + Q D
Sbjct: 212 NQKEHRNLPFMRELRYLFALLVGTKRKYVDPSRAVEILK--------DAFKSNDSQQQDV 263
Query: 430 HEFLSQCLDQLKEDMEKLNKTWKTEPVSGEENSPDISATRAYTCPVITNLEFEVQHSIIC 489
EF + LD L ED ++ +T+ + ++ R V+ +FE
Sbjct: 264 SEFTHKLLDWL-EDAFQMKAEEETDEEKPKNPMVELFYGRFLAVGVLEGKKFE------- 315
Query: 490 KACGEIIPKREQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELEYSCEKCGGKCALVR 549
E F + + K + + L+ E+E + GK
Sbjct: 316 --------NTEMFGQYPLQVNGFK------DLHECLEAAMIEGEIESLHSENSGKSG-QE 360
Query: 550 HKFNRLPRVLILHLKRYSFNVALSLNNKIGQQVIIPRYLTLSSHCTEN 597
H F LP VL L R+ FN AL KI ++ P+ L L + N
Sbjct: 361 HWFTELPPVLTFELSRFEFNQALGRPEKIHNKLEFPQVLYLDRYMHRN 408
Score = 41.6 bits (96), Expect = 0.004
Identities = 27/92 (29%), Positives = 48/92 (52%), Gaps = 7/92 (7%)
Query: 889 YRLISVVSHIGSTSSSGHYISDVYDIKKQAWFTYNDLEVSKIQEAAVQSD-----RDRSG 943
YRL +V+ H G +++GHY + ++D ++ W YND+ V+K + D R+ S
Sbjct: 591 YRLHAVLVHEGQ-ANAGHYWAYIFDHRESRWMKYNDIAVTKSSWEELVRDSFGGYRNASA 649
Query: 944 YIFFYMHKEIFDELLETEKNSQSLSTEVGKTT 975
Y Y++ + L++ E N ++ VG T
Sbjct: 650 YCLMYINDKA-QFLIQEEFNKETGQPLVGIET 680
>gi|24234683 ubiquitin specific peptidase 11 [Homo sapiens]
Length = 963
Score = 59.3 bits (142), Expect = 2e-08
Identities = 53/206 (25%), Positives = 89/206 (43%), Gaps = 27/206 (13%)
Query: 337 QQQLQGFSNLGNTCYMNAILQSLFSL----QSFANDLLKQGIPWKKIPLNA---LIRRFA 389
Q + G +NLGNTC+MN+ LQ L ++ + F N+ + + ++ PL + +A
Sbjct: 305 QPGICGLTNLGNTCFMNSALQCLSNVPQLTEYFLNNCYLEELNFRN-PLGMKGEIAEAYA 363
Query: 390 HLLVKKDICNSETKKDLLKKVKNAISATAERFSGYMQNDAHEFLSQCLDQLKEDMEKLNK 449
L+ K + + + KN + A +F GY Q+D+ E LS LD L ED+ ++ K
Sbjct: 364 DLV--KQAWSGHHRSIVPHVFKNKVGHFASQFLGYQQHDSQELLSFLLDGLHEDLNRVKK 421
Query: 450 TWKTEPVSGEENSPDISAT--------RAYTCPVITNLEFEVQHSIICKACGEIIPKREQ 501
E + PD R ++ + +++C CG + +
Sbjct: 422 KEYVE-LCDAAGRPDQEVAQEAWQNHKRRNDSVIVDTFHGLFKSTLVCPDCGNVSVTFDP 480
Query: 502 FNDLSIDLPRRKK--------PLPPR 519
F LS+ LP K P+ PR
Sbjct: 481 FCYLSVPLPISHKRVLEVFFIPMDPR 506
Score = 32.0 bits (71), Expect = 2.9
Identities = 19/56 (33%), Positives = 30/56 (53%), Gaps = 5/56 (8%)
Query: 518 PRSIQDSLDLFFRAEELE----YSCEKCGG-KCALVRHKFNRLPRVLILHLKRYSF 568
P +Q+ ++LF E LE + C C + A + LP +LI+HLKR+S+
Sbjct: 778 PVRLQECIELFTTVETLEKENPWYCPSCKQHQLATKKLDLWMLPEILIIHLKRFSY 833
>gi|21361749 ubiquitin thioesterase 49 [Homo sapiens]
Length = 640
Score = 58.9 bits (141), Expect = 2e-08
Identities = 57/203 (28%), Positives = 89/203 (43%), Gaps = 40/203 (19%)
Query: 421 FSGYMQNDAHEFLSQCLDQLKEDMEKLNKTWK-TEPVSGEENSPDISATRAYTCPVITNL 479
F GY Q DA EFL + L ++++++E T + P S + T+ V T
Sbjct: 392 FRGYDQQDAQEFLCELLHKVQQELESEGTTRRILIPFSQRK------LTKQVLKVVNTIF 445
Query: 480 EFEVQHSIICKACGEIIPKREQFNDLSIDLPRR----KKPLPPRS-----IQDSLDLFFR 530
++ + C +C E F DLS++ P R +K P + + + L F
Sbjct: 446 HGQLLSQVTCISCNYKSNTIEPFWDLSLEFPERYHCIEKGFVPLNQTECLLTEMLAKFTE 505
Query: 531 AEELE---YSCEKCGGKCALVRHKFN----------------RLPRVLILHLKRYSFNVA 571
E LE Y+C++C K R K N RLP+VL LHLKR+ ++
Sbjct: 506 TEALEGRIYACDQCNSK----RRKSNPKPLVLSEARKQLMIYRLPQVLRLHLKRFRWS-G 560
Query: 572 LSLNNKIGQQVIIPRYLTLSSHC 594
+ KIG V+ + LT+ +C
Sbjct: 561 RNHREKIGVHVVFDQVLTMEPYC 583
Score = 38.1 bits (87), Expect = 0.041
Identities = 17/24 (70%), Positives = 18/24 (75%)
Query: 342 GFSNLGNTCYMNAILQSLFSLQSF 365
G NLGNTCYMN+ILQ L LQ F
Sbjct: 254 GLRNLGNTCYMNSILQVLSHLQKF 277
>gi|50312664 ubiquitin specific protease 16 isoform b [Homo sapiens]
Length = 822
Score = 58.2 bits (139), Expect = 4e-08
Identities = 73/295 (24%), Positives = 125/295 (42%), Gaps = 30/295 (10%)
Query: 327 KPRVPLSSHQQQQLQGFSNLGNTCYMNAILQSLFS---LQSFANDLLKQGIPWKKIPLNA 383
K P++S Q ++G SNLGNTC+ NA++Q+L L+ ++ G K P +
Sbjct: 181 KENPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDL 240
Query: 384 LIRRFAHL---------LVKKDICNS--ETKKDLL--KKVKNAISATAERFSGYMQNDAH 430
+ + L N ETKK ++ K++ + + A RF GY Q D+
Sbjct: 241 ALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQ 300
Query: 431 EFLSQCLDQLK-EDMEKLNKTW------KTEPVSGEENSPDISATRAYTCPVITNLEF-- 481
E L LD ++ E+ ++++K TE + E + + + P + F
Sbjct: 301 ELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGG 360
Query: 482 EVQHSIICKACGEIIPKREQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELEYSCEKC 541
E+ I+C C + E F DLS LP +S+ D +L E+ + E+
Sbjct: 361 ELTSMIMCDQCRTVSLVHESFLDLS--LPVLDDQSGKKSVNDK-NLKKTVEDEDQDSEEE 417
Query: 542 GGKCALVRHKFNRLPRVLILHL-KRYSFNVALSLNNKIGQQVIIPRYLTLSSHCT 595
+ ++ + + +P HL K+ N+ QQ I + L L+ CT
Sbjct: 418 KDNDSYIKER-SDIPSGTSKHLQKKAKKQAKKQAKNQRRQQKIQGKVLHLNDICT 471
>gi|5454156 ubiquitin specific protease 16 isoform a [Homo sapiens]
Length = 823
Score = 58.2 bits (139), Expect = 4e-08
Identities = 73/295 (24%), Positives = 125/295 (42%), Gaps = 30/295 (10%)
Query: 327 KPRVPLSSHQQQQLQGFSNLGNTCYMNAILQSLFS---LQSFANDLLKQGIPWKKIPLNA 383
K P++S Q ++G SNLGNTC+ NA++Q+L L+ ++ G K P +
Sbjct: 182 KENPPMNSPCQITVKGLSNLGNTCFFNAVMQNLSQTPVLRELLKEVKMSGTIVKIEPPDL 241
Query: 384 LIRRFAHL---------LVKKDICNS--ETKKDLL--KKVKNAISATAERFSGYMQNDAH 430
+ + L N ETKK ++ K++ + + A RF GY Q D+
Sbjct: 242 ALTEPLEINLEPPGPLTLAMSQFLNEMQETKKGVVTPKELFSQVCKKAVRFKGYQQQDSQ 301
Query: 431 EFLSQCLDQLK-EDMEKLNKTW------KTEPVSGEENSPDISATRAYTCPVITNLEF-- 481
E L LD ++ E+ ++++K TE + E + + + P + F
Sbjct: 302 ELLRYLLDGMRAEEHQRVSKGILKAFGNSTEKLDEELKNKVKDYEKKKSMPSFVDRIFGG 361
Query: 482 EVQHSIICKACGEIIPKREQFNDLSIDLPRRKKPLPPRSIQDSLDLFFRAEELEYSCEKC 541
E+ I+C C + E F DLS LP +S+ D +L E+ + E+
Sbjct: 362 ELTSMIMCDQCRTVSLVHESFLDLS--LPVLDDQSGKKSVNDK-NLKKTVEDEDQDSEEE 418
Query: 542 GGKCALVRHKFNRLPRVLILHL-KRYSFNVALSLNNKIGQQVIIPRYLTLSSHCT 595
+ ++ + + +P HL K+ N+ QQ I + L L+ CT
Sbjct: 419 KDNDSYIKER-SDIPSGTSKHLQKKAKKQAKKQAKNQRRQQKIQGKVLHLNDICT 472
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.128 0.359
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 37,689,091
Number of Sequences: 37866
Number of extensions: 1820740
Number of successful extensions: 9276
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 132
Number of HSP's successfully gapped in prelim test: 368
Number of HSP's that attempted gapping in prelim test: 7588
Number of HSP's gapped (non-prelim): 1547
length of query: 979
length of database: 18,247,518
effective HSP length: 112
effective length of query: 867
effective length of database: 14,006,526
effective search space: 12143658042
effective search space used: 12143658042
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.