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Search of human proteins with 188497642
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|188497642 ARHGAP15 [Homo sapiens]
(475 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|188497642 ARHGAP15 [Homo sapiens] 944 0.0
gi|26986534 Rho GTPase activating protein 12 [Homo sapiens] 382 e-106
gi|226693398 Rho GTPase activating protein 27 isoform b [Homo sa... 356 2e-98
gi|40548322 Rho GTPase activating protein 27 isoform a [Homo sap... 356 2e-98
gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo sap... 331 8e-91
gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo sap... 331 8e-91
gi|122939151 Rho GTPase activating protein 9 isoform 2 [Homo sap... 255 5e-68
gi|203097003 Rho GTPase activating protein 21 [Homo sapiens] 172 8e-43
gi|224458284 Rho GTPase activating protein 23 [Homo sapiens] 158 1e-38
gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo s... 143 3e-34
gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens] 132 7e-31
gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens] 132 7e-31
gi|4757980 beta chimerin isoform 2 [Homo sapiens] 130 2e-30
gi|91106928 beta chimerin isoform 1 [Homo sapiens] 130 2e-30
gi|208022687 GTPase regulator associated with the focal adhesion... 129 4e-30
gi|7662208 GTPase regulator associated with the focal adhesion k... 129 4e-30
gi|229094128 active breakpoint cluster region-related protein i... 129 6e-30
gi|38679957 active breakpoint cluster region-related protein is... 129 6e-30
gi|38679954 active breakpoint cluster region-related protein is... 129 6e-30
gi|4505507 oligophrenin 1 [Homo sapiens] 127 2e-29
gi|50843948 Rho GTPase activating protein 10 [Homo sapiens] 127 2e-29
gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens] 125 1e-28
gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens] 125 1e-28
gi|23510413 sorting nexin 26 [Homo sapiens] 124 1e-28
gi|218083800 Rho GTPase-activating protein isoform 1 [Homo sapiens] 122 5e-28
gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo ... 122 9e-28
gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo sap... 121 1e-27
gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo sap... 121 1e-27
gi|29469071 Rho GTPase-activating protein isoform 2 [Homo sapiens] 119 8e-27
gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapi... 115 7e-26
>gi|188497642 ARHGAP15 [Homo sapiens]
Length = 475
Score = 944 bits (2441), Expect = 0.0
Identities = 475/475 (100%), Positives = 475/475 (100%)
Query: 1 MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHR 60
MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHR
Sbjct: 1 MQKSTNSDTSVETLNSTRQGTGAVQMRIKNANSHHDRLSQSKSMILTDVGKVTEPISRHR 60
Query: 61 RNHSQHILKDVIPPLEQLMVEKEGYLQKAKIADGGKKLRKNWSTSWIVLSSRRIEFYKES 120
RNHSQHILKDVIPPLEQLMVEKEGYLQKAKIADGGKKLRKNWSTSWIVLSSRRIEFYKES
Sbjct: 61 RNHSQHILKDVIPPLEQLMVEKEGYLQKAKIADGGKKLRKNWSTSWIVLSSRRIEFYKES 120
Query: 121 KQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDW 180
KQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDW
Sbjct: 121 KQQALSNMKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDW 180
Query: 181 FHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHH 240
FHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHH
Sbjct: 181 FHAIKNAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHH 240
Query: 241 SASDTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQ 300
SASDTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQ
Sbjct: 241 SASDTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQ 300
Query: 301 CIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFR 360
CIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFR
Sbjct: 301 CIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFR 360
Query: 361 ELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKA 420
ELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKA
Sbjct: 361 ELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKA 420
Query: 421 SKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIFGSEED 475
SKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIFGSEED
Sbjct: 421 SKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIFGSEED 475
>gi|26986534 Rho GTPase activating protein 12 [Homo sapiens]
Length = 846
Score = 382 bits (981), Expect = e-106
Identities = 204/393 (51%), Positives = 271/393 (68%), Gaps = 14/393 (3%)
Query: 81 EKEGYLQKAKIADGGKKLRKNWSTSWIVLSSRRIEFYKESKQQALSNMKTGHKPE-SVDL 139
EK G L KIA+ GKK+RKNW +SW VL + F K KPE +VDL
Sbjct: 465 EKYGLLNVTKIAENGKKVRKNWLSSWAVLQGSSLLFTKTQGSSTSWFGSNQSKPEFTVDL 524
Query: 140 CGAHIEWA-KEKSSRKNVFQITTVSGNEFLLQSDIDFIILDWFHAIKNAIDRLPKDSSCP 198
GA IE A K+KSS+KNVF++ T G E L+QSD D +I DWF + + I+ ++
Sbjct: 525 KGATIEMASKDKSSKKNVFELKTRQGTELLIQSDNDTVINDWFKVLSSTINNQAVETD-- 582
Query: 199 SRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHHSASDTSDKNRVKSRLKKF 258
E + + S + H D ++++ + +K F++ S+ D+S++ + K LKKF
Sbjct: 583 ----EGIEEEIPDSPGIEKH---DKEKEQKDPKKLRSFKV--SSIDSSEQKKTKKNLKKF 633
Query: 259 ITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRV 318
+TRRP+L+ ++EKG IKDQ+FGS+L +C+REN TVP FVK CIE VE+ GLD+DGIYRV
Sbjct: 634 LTRRPTLQAVREKGYIKDQVFGSNLANLCQRENGTVPKFVKLCIEHVEEHGLDIDGIYRV 693
Query: 319 SGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEA 378
SGNLA IQKLRF VN +EKL+L+DS+WEDIHV+TGALKMFFRELPEPLF ++ F FV A
Sbjct: 694 SGNLAVIQKLRFAVNHDEKLDLNDSKWEDIHVITGALKMFFRELPEPLFTFNHFNDFVNA 753
Query: 379 IKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTL 438
I KQ+ R+ AVK L+++LP PN+DTM++LF HL +++ KN M+ QS+ IVFGPTL
Sbjct: 754 I-KQEPRQRVAAVKDLIRQLPKPNQDTMQILFRHLRRVIENGEKNRMTYQSIAIVFGPTL 812
Query: 439 LRAENETGNMAIHMVYQNQIAELMLSEYSKIFG 471
L+ E ETGN+A+H VYQNQI EL+L E S IFG
Sbjct: 813 LKPEKETGNIAVHTVYQNQIVELILLELSSIFG 845
>gi|226693398 Rho GTPase activating protein 27 isoform b [Homo
sapiens]
Length = 521
Score = 356 bits (914), Expect = 2e-98
Identities = 191/397 (48%), Positives = 264/397 (66%), Gaps = 13/397 (3%)
Query: 80 VEKEGYLQKAKIADGGKKLRK-NWSTSWIVLSSRRIEFYKESKQQALSNMKTGHK---PE 135
++K G L + K AD GK+LRK +WS SW VL + F+K+SK A ++ K PE
Sbjct: 129 LDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPE 188
Query: 136 -SVDLCGAHIEWA-KEKSSRKNVFQITTVSGNEFLLQSDIDFIILDWFHAIKNAIDRLPK 193
+V+L GA + WA K+KSSRKNV ++ + G+E+L+Q D + II W AI I L
Sbjct: 189 YTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQEL-- 246
Query: 194 DSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHHSASDTSDKNRVKS 253
+ P E ++ SS L S +E++ + R + SD ++V+
Sbjct: 247 SAELPPEESESSRVDFGSSERLGSW-----QEKEEDARPNAAAPALGPVGLESDLSKVRH 301
Query: 254 RLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVD 313
+L+KF+ RRP+L++L+EKG IKDQ+FG L +CERE S VP FV+QCI AVE RGLD+D
Sbjct: 302 KLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDID 361
Query: 314 GIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFE 373
G+YR+SGNLATIQKLR+ V+ +E+L+LDD +WED+HV+TGALK+FFRELPEPLFP+S F
Sbjct: 362 GLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFR 421
Query: 374 QFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIV 433
QF+ AIK QD R V+ LV+ LP PN DT+++LF HL +++ +N MS QS+ IV
Sbjct: 422 QFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIV 481
Query: 434 FGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIF 470
FGPTLLR E E +M + MV+QNQ+ EL+L + + IF
Sbjct: 482 FGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIF 518
>gi|40548322 Rho GTPase activating protein 27 isoform a [Homo
sapiens]
Length = 548
Score = 356 bits (914), Expect = 2e-98
Identities = 191/397 (48%), Positives = 264/397 (66%), Gaps = 13/397 (3%)
Query: 80 VEKEGYLQKAKIADGGKKLRK-NWSTSWIVLSSRRIEFYKESKQQALSNMKTGHK---PE 135
++K G L + K AD GK+LRK +WS SW VL + F+K+SK A ++ K PE
Sbjct: 156 LDKAGVLHRTKTADKGKRLRKKHWSASWTVLEGGVLTFFKDSKTSAAGGLRQPSKFSTPE 215
Query: 136 -SVDLCGAHIEWA-KEKSSRKNVFQITTVSGNEFLLQSDIDFIILDWFHAIKNAIDRLPK 193
+V+L GA + WA K+KSSRKNV ++ + G+E+L+Q D + II W AI I L
Sbjct: 216 YTVELRGATLSWAPKDKSSRKNVLELRSRDGSEYLIQHDSEAIISTWHKAIAQGIQEL-- 273
Query: 194 DSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHHSASDTSDKNRVKS 253
+ P E ++ SS L S +E++ + R + SD ++V+
Sbjct: 274 SAELPPEESESSRVDFGSSERLGSW-----QEKEEDARPNAAAPALGPVGLESDLSKVRH 328
Query: 254 RLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVD 313
+L+KF+ RRP+L++L+EKG IKDQ+FG L +CERE S VP FV+QCI AVE RGLD+D
Sbjct: 329 KLRKFLQRRPTLQSLREKGYIKDQVFGCALAALCERERSRVPRFVQQCIRAVEARGLDID 388
Query: 314 GIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFE 373
G+YR+SGNLATIQKLR+ V+ +E+L+LDD +WED+HV+TGALK+FFRELPEPLFP+S F
Sbjct: 389 GLYRISGNLATIQKLRYKVDHDERLDLDDGRWEDVHVITGALKLFFRELPEPLFPFSHFR 448
Query: 374 QFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIV 433
QF+ AIK QD R V+ LV+ LP PN DT+++LF HL +++ +N MS QS+ IV
Sbjct: 449 QFIAAIKLQDQARRSRCVRDLVRSLPAPNHDTLRMLFQHLCRVIEHGEQNRMSVQSVAIV 508
Query: 434 FGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIF 470
FGPTLLR E E +M + MV+QNQ+ EL+L + + IF
Sbjct: 509 FGPTLLRPEVEETSMPMTMVFQNQVVELILQQCADIF 545
>gi|122939147 Rho GTPase activating protein 9 isoform 1 [Homo
sapiens]
Length = 731
Score = 331 bits (849), Expect = 8e-91
Identities = 183/428 (42%), Positives = 265/428 (61%), Gaps = 40/428 (9%)
Query: 74 PLEQLM-----VEKEGYLQKAKIADGGKKLRKNWSTSWIVLSSRRIEFYKESKQQALSNM 128
PL QL+ VEK G L KIA GG+KLRKNW SW+VL+ + FY+E A S+
Sbjct: 312 PLPQLLDDPHEVEKSGLLNMTKIAQGGRKLRKNWGPSWVVLTGNSLVFYREPPPTAPSSG 371
Query: 129 --KTGHKPES-VDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDWFHAIK 185
G +PES VDL GA + + SSR+NV I T+ G+EFLLQSD + + W A++
Sbjct: 372 WGPAGSRPESSVDLRGAALAHGRHLSSRRNVLHIRTIPGHEFLLQSDHETELRAWHRALR 431
Query: 186 NAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHHSAS-- 243
I+RL +++ LEL ++ S EL + D +E++ E + RL S
Sbjct: 432 TVIERLDRENP-----LEL-RLSGSGPAELSAGED---EEEESELVSKPLLRLSSRRSSI 482
Query: 244 ---DTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQ 300
+ +++NRV+++LK+ I +RP L++LQE+GL++DQ+FG L +C+RE TVP F++
Sbjct: 483 RGPEGTEQNRVRNKLKRLIAKRPPLQSLQERGLLRDQVFGCQLESLCQREGDTVPSFLRL 542
Query: 301 CIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVN------------------QEEKLNLDD 342
CI AV+KRGLDVDGIYRVSGNLA +QKLRF+V+ QE +L+LD
Sbjct: 543 CIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDS 602
Query: 343 SQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPN 402
++W+DIHVVTGALK+F RELP+PL P F A+ ++ + ++ L+ +P PN
Sbjct: 603 TEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQELIGSMPKPN 662
Query: 403 RDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELM 462
DT++ L HL +++A + KN M+ +LGIVFGPTL R E ET + A H +Y Q+ +LM
Sbjct: 663 HDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHALYPGQLVQLM 722
Query: 463 LSEYSKIF 470
L+ ++ +F
Sbjct: 723 LTNFTSLF 730
>gi|122939149 Rho GTPase activating protein 9 isoform 3 [Homo
sapiens]
Length = 547
Score = 331 bits (849), Expect = 8e-91
Identities = 183/428 (42%), Positives = 265/428 (61%), Gaps = 40/428 (9%)
Query: 74 PLEQLM-----VEKEGYLQKAKIADGGKKLRKNWSTSWIVLSSRRIEFYKESKQQALSNM 128
PL QL+ VEK G L KIA GG+KLRKNW SW+VL+ + FY+E A S+
Sbjct: 128 PLPQLLDDPHEVEKSGLLNMTKIAQGGRKLRKNWGPSWVVLTGNSLVFYREPPPTAPSSG 187
Query: 129 --KTGHKPES-VDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDWFHAIK 185
G +PES VDL GA + + SSR+NV I T+ G+EFLLQSD + + W A++
Sbjct: 188 WGPAGSRPESSVDLRGAALAHGRHLSSRRNVLHIRTIPGHEFLLQSDHETELRAWHRALR 247
Query: 186 NAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHHSAS-- 243
I+RL +++ LEL ++ S EL + D +E++ E + RL S
Sbjct: 248 TVIERLDRENP-----LEL-RLSGSGPAELSAGED---EEEESELVSKPLLRLSSRRSSI 298
Query: 244 ---DTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQ 300
+ +++NRV+++LK+ I +RP L++LQE+GL++DQ+FG L +C+RE TVP F++
Sbjct: 299 RGPEGTEQNRVRNKLKRLIAKRPPLQSLQERGLLRDQVFGCQLESLCQREGDTVPSFLRL 358
Query: 301 CIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVN------------------QEEKLNLDD 342
CI AV+KRGLDVDGIYRVSGNLA +QKLRF+V+ QE +L+LD
Sbjct: 359 CIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDS 418
Query: 343 SQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPN 402
++W+DIHVVTGALK+F RELP+PL P F A+ ++ + ++ L+ +P PN
Sbjct: 419 TEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAALALSESEQCLSQIQELIGSMPKPN 478
Query: 403 RDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELM 462
DT++ L HL +++A + KN M+ +LGIVFGPTL R E ET + A H +Y Q+ +LM
Sbjct: 479 HDTLRYLLEHLCRVIAHSDKNRMTPHNLGIVFGPTLFRPEQETSDPAAHALYPGQLVQLM 538
Query: 463 LSEYSKIF 470
L+ ++ +F
Sbjct: 539 LTNFTSLF 546
>gi|122939151 Rho GTPase activating protein 9 isoform 2 [Homo
sapiens]
Length = 640
Score = 255 bits (652), Expect = 5e-68
Identities = 149/337 (44%), Positives = 208/337 (61%), Gaps = 40/337 (11%)
Query: 74 PLEQLM-----VEKEGYLQKAKIADGGKKLRKNWSTSWIVLSSRRIEFYKESKQQALSNM 128
PL QL+ VEK G L KIA GG+KLRKNW SW+VL+ + FY+E A S+
Sbjct: 312 PLPQLLDDPHEVEKSGLLNMTKIAQGGRKLRKNWGPSWVVLTGNSLVFYREPPPTAPSSG 371
Query: 129 --KTGHKPES-VDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDWFHAIK 185
G +PES VDL GA + + SSR+NV I T+ G+EFLLQSD + + W A++
Sbjct: 372 WGPAGSRPESSVDLRGAALAHGRHLSSRRNVLHIRTIPGHEFLLQSDHETELRAWHRALR 431
Query: 186 NAIDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSLMFRLHHSAS-- 243
I+RL +++ LEL ++ S EL + D +E++ E + RL S
Sbjct: 432 TVIERLDRENP-----LEL-RLSGSGPAELSAGED---EEEESELVSKPLLRLSSRRSSI 482
Query: 244 ---DTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQ 300
+ +++NRV+++LK+ I +RP L++LQE+GL++DQ+FG L +C+RE TVP F++
Sbjct: 483 RGPEGTEQNRVRNKLKRLIAKRPPLQSLQERGLLRDQVFGCQLESLCQREGDTVPSFLRL 542
Query: 301 CIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVN------------------QEEKLNLDD 342
CI AV+KRGLDVDGIYRVSGNLA +QKLRF+V+ QE +L+LD
Sbjct: 543 CIAAVDKRGLDVDGIYRVSGNLAVVQKLRFLVDRERAVTSDGRYVFPEQPGQEGRLDLDS 602
Query: 343 SQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAI 379
++W+DIHVVTGALK+F RELP+PL P F A+
Sbjct: 603 TEWDDIHVVTGALKLFLRELPQPLVPPLLLPHFRAAL 639
>gi|203097003 Rho GTPase activating protein 21 [Homo sapiens]
Length = 1958
Score = 172 bits (435), Expect = 8e-43
Identities = 142/472 (30%), Positives = 231/472 (48%), Gaps = 47/472 (9%)
Query: 29 KNANSHHDRLSQSKSMILTDVGKVTEPISRHRRNHSQHILKDVIPPLEQLMVEKEGYLQ- 87
++A +S K + + D K +E S R++ S + D KEG+L
Sbjct: 891 EDAKLSFKHVSSLKGIKIADSQKSSED-SGSRKDSSSEVFSDAA---------KEGWLHF 940
Query: 88 KAKIADGGKKLR---KNWSTSWIVLSSRRIEFYKESKQQALSNMKTGHKPESVDLCGAHI 144
+ + D GK++ + W ++VL + YK+ ++Q + + +P SV+ C I
Sbjct: 941 RPLVTDKGKRVGGSIRPWKQMYVVLRGHSLYLYKDKREQTTPSEE--EQPISVNACLIDI 998
Query: 145 EWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDWFHAIKNAIDRLPKDSSCPSRNL-- 202
+++ K RKNVF++TT S E L Q++ +L W I+ + + +D+ +R+L
Sbjct: 999 SYSETK--RKNVFRLTT-SDCECLFQAEDRDDMLAWIKTIQESSNLNEEDTGVTNRDLIS 1055
Query: 203 --------------ELFKIQRSSST--ELLSHYDSDIKEQKPEHRKSLMFRLHHSASDTS 246
+L K R S + + L S+ K Q P K R S DTS
Sbjct: 1056 RRIKEYNNLMSKAEQLPKTPRQSLSIRQTLLGAKSEPKTQSPHSPKEESERKLLSKDDTS 1115
Query: 247 DKNRVKSRLKKFITRRPSL--KTLQEKGLIKDQIFGSHLHKVCERE-NSTVPWFVKQCIE 303
+ K +K I PS+ KT ++K FG L N +P V C +
Sbjct: 1116 PP-KDKGTWRKGI---PSIMRKTFEKKPTATGT-FGVRLDDCPPAHTNRYIPLIVDICCK 1170
Query: 304 AVEKRGLDVDGIYRVSGNLATIQKLRFIVNQE-EKLNLDDSQWEDIHVVTGALKMFFREL 362
VE+RGL+ GIYRV GN A I ++ +N+ +++ D +W D++V++ LK FFR+L
Sbjct: 1171 LVEERGLEYTGIYRVPGNNAAISSMQEELNKGMADIDIQDDKWRDLNVISSLLKSFFRKL 1230
Query: 363 PEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASK 422
PEPLF + F+EA +K+D R++ +K L+ LP + +T+K L HL + + K
Sbjct: 1231 PEPLFTNDKYADFIEANRKEDPLDRLKTLKRLIHDLPEHHYETLKFLSAHLKTVAENSEK 1290
Query: 423 NLMSTQSLGIVFGPTLLR-AENETGNMAIHMVYQNQIAELMLSEYSKIFGSE 473
N M ++L IVFGPTL+R +E+ +M HM Q +I E ++ + F E
Sbjct: 1291 NKMEPRNLAIVFGPTLVRTSEDNMTHMVTHMPDQYKIVETLIQHHDWFFTEE 1342
>gi|224458284 Rho GTPase activating protein 23 [Homo sapiens]
Length = 1397
Score = 158 bits (399), Expect = 1e-38
Identities = 120/420 (28%), Positives = 199/420 (47%), Gaps = 30/420 (7%)
Query: 80 VEKEGYLQ-KAKIADGGKKLR---KNWSTSWIVLSSRRIEFYKESKQQ--------ALSN 127
+ +EG+L K + GKK + W + L +R + KE ++ A
Sbjct: 595 IRREGWLYYKQILTKKGKKAGSGLRQWKRVYAALRARSLSLSKERREPGPAAAGAAAAGA 654
Query: 128 MKTGHKPESVDLCGAHIEWAKEKSSRKNVFQITTVSGNEFLLQSDIDFIILDWFHAIKNA 187
+ P + C I +++ K R++VF++TT E+L Q++ +L W AI+
Sbjct: 655 GEDEAAPVCIGSCLVDISYSETK--RRHVFRLTTADFCEYLFQAEDRDDMLGWIRAIREN 712
Query: 188 IDRLPKDSSCPSRNLELFKIQRSSSTELLSHYDSDIKEQKPEHRKSL----MFRLHHSAS 243
+D C ++ L K+ + +SH + P+ + L L SA+
Sbjct: 713 SRAEGEDPGCANQALISKKL---NDYRKVSHSSGPKADSSPKGSRGLGGLKSEFLKQSAA 769
Query: 244 DTSDKNRVKSRLKKFITRRPS----LKTLQEKGLIKDQIFGSHLHKVCE--RENSTVPWF 297
+ + K P + +++ + FG L + C+ EN VP
Sbjct: 770 RGLRTQDLPAGSKDDSAAAPKTPWGINIIKKNKKAAPRAFGVRLEE-CQPATENQRVPLI 828
Query: 298 VKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEE-KLNLDDSQWEDIHVVTGALK 356
V C VE RGL+ GIYRV GN A + L+ +N+ +NL D +W+D++V++ LK
Sbjct: 829 VAACCRIVEARGLESTGIYRVPGNNAVVSSLQEQLNRGPGDINLQDERWQDLNVISSLLK 888
Query: 357 MFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKI 416
FFR+LPEPLF + F+EA + +D R+ ++ L++ LP +T+K L GHL I
Sbjct: 889 SFFRKLPEPLFTDDKYNDFIEANRIEDARERMRTLRKLIRDLPGHYYETLKFLVGHLKTI 948
Query: 417 VAKASKNLMSTQSLGIVFGPTLLR-AENETGNMAIHMVYQNQIAELMLSEYSKIFGSEED 475
+ KN M ++L +VFGPTL+R +E+ +M HM + +I E ++ F EED
Sbjct: 949 ADHSEKNKMEPRNLALVFGPTLVRTSEDNMTDMVTHMPDRYKIVETLIQHSDWFFSDEED 1008
>gi|221307575 Rho-type GTPase-activating protein FLJ32810 [Homo
sapiens]
Length = 874
Score = 143 bits (361), Expect = 3e-34
Identities = 70/182 (38%), Positives = 112/182 (61%), Gaps = 4/182 (2%)
Query: 297 FVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLR---FIVNQEEKLNLDDSQWEDIHVVTG 353
FV++CI+AVE RG+ + G+YR+ G + +QKL F +++D W++ +T
Sbjct: 397 FVRKCIQAVETRGITILGLYRIGGVNSKVQKLMNTTFSPKSPPDIDIDIELWDN-KTITS 455
Query: 354 ALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHL 413
LK + R L EPL Y + F+ A+K D N R+EAV +LV KLP NR+ + +L HL
Sbjct: 456 GLKNYLRCLAEPLMTYKLHKDFIIAVKSDDQNYRVEAVHALVHKLPEKNREMLDILIKHL 515
Query: 414 TKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIFGSE 473
K+ + +NLM+ +LG++FGPTL+RA+ ET +++ +QN + E+++ Y KIF +
Sbjct: 516 VKVSLHSQQNLMTVSNLGVIFGPTLMRAQEETVAAMMNIKFQNIVVEILIEHYEKIFHTA 575
Query: 474 ED 475
D
Sbjct: 576 PD 577
>gi|4502813 chimerin (chimaerin) 1 isoform a [Homo sapiens]
Length = 459
Score = 132 bits (332), Expect = 7e-31
Identities = 64/196 (32%), Positives = 119/196 (60%), Gaps = 2/196 (1%)
Query: 277 QIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQE- 335
+++ L + + + P V CI +E RGL+ +G+YRVSG I+ ++ +++
Sbjct: 264 KVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDG 323
Query: 336 EKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLV 395
EK ++ + +EDI+++TGALK++FR+LP PL Y + +F+E+ K D + ++E + +
Sbjct: 324 EKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEAL 383
Query: 396 QKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMV-Y 454
+ LPP + +T++ L HL ++ +NLM+ ++LGIVFGPTL+R+ A++ + Y
Sbjct: 384 KLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRY 443
Query: 455 QNQIAELMLSEYSKIF 470
Q + EL++ +F
Sbjct: 444 QRLVVELLIKNEDILF 459
>gi|209364623 chimerin (chimaerin) 1 isoform b [Homo sapiens]
Length = 433
Score = 132 bits (332), Expect = 7e-31
Identities = 64/196 (32%), Positives = 119/196 (60%), Gaps = 2/196 (1%)
Query: 277 QIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQE- 335
+++ L + + + P V CI +E RGL+ +G+YRVSG I+ ++ +++
Sbjct: 238 KVYSCDLTTLVKAHTTKRPMVVDMCIREIESRGLNSEGLYRVSGFSDLIEDVKMAFDRDG 297
Query: 336 EKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLV 395
EK ++ + +EDI+++TGALK++FR+LP PL Y + +F+E+ K D + ++E + +
Sbjct: 298 EKADISVNMYEDINIITGALKLYFRDLPIPLITYDAYPKFIESAKIMDPDEQLETLHEAL 357
Query: 396 QKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMV-Y 454
+ LPP + +T++ L HL ++ +NLM+ ++LGIVFGPTL+R+ A++ + Y
Sbjct: 358 KLLPPAHCETLRYLMAHLKRVTLHEKENLMNAENLGIVFGPTLMRSPELDAMAALNDIRY 417
Query: 455 QNQIAELMLSEYSKIF 470
Q + EL++ +F
Sbjct: 418 QRLVVELLIKNEDILF 433
>gi|4757980 beta chimerin isoform 2 [Homo sapiens]
Length = 468
Score = 130 bits (328), Expect = 2e-30
Identities = 68/211 (32%), Positives = 123/211 (58%), Gaps = 9/211 (4%)
Query: 262 RPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGN 321
+P LK +++ ++ L + + N+ P V CI +E RGL +G+YRVSG
Sbjct: 265 QPDLKRIKK-------VYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGF 317
Query: 322 LATIQKLRFIVNQE-EKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIK 380
I+ ++ +++ EK ++ + + DI+++TGALK++FR+LP P+ Y + +F++A K
Sbjct: 318 TEHIEDVKMAFDRDGEKADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAK 377
Query: 381 KQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLR 440
+ + R+EAV ++ LPP + +T++ L HL K+ N M+ ++LGIVFGPTL+R
Sbjct: 378 ISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMR 437
Query: 441 AENETGNMAIH-MVYQNQIAELMLSEYSKIF 470
++ +H M YQ I ++++ +F
Sbjct: 438 PPEDSTLTTLHDMRYQKLIVQILIENEDVLF 468
>gi|91106928 beta chimerin isoform 1 [Homo sapiens]
Length = 332
Score = 130 bits (328), Expect = 2e-30
Identities = 68/211 (32%), Positives = 123/211 (58%), Gaps = 9/211 (4%)
Query: 262 RPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGN 321
+P LK +++ ++ L + + N+ P V CI +E RGL +G+YRVSG
Sbjct: 129 QPDLKRIKK-------VYCCDLTTLVKAHNTQRPMVVDICIREIEARGLKSEGLYRVSGF 181
Query: 322 LATIQKLRFIVNQE-EKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIK 380
I+ ++ +++ EK ++ + + DI+++TGALK++FR+LP P+ Y + +F++A K
Sbjct: 182 TEHIEDVKMAFDRDGEKADISANVYPDINIITGALKLYFRDLPIPVITYDTYSKFIDAAK 241
Query: 381 KQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLR 440
+ + R+EAV ++ LPP + +T++ L HL K+ N M+ ++LGIVFGPTL+R
Sbjct: 242 ISNADERLEAVHEVLMLLPPAHYETLRYLMIHLKKVTMNEKDNFMNAENLGIVFGPTLMR 301
Query: 441 AENETGNMAIH-MVYQNQIAELMLSEYSKIF 470
++ +H M YQ I ++++ +F
Sbjct: 302 PPEDSTLTTLHDMRYQKLIVQILIENEDVLF 332
>gi|208022687 GTPase regulator associated with the focal adhesion
kinase pp125 isoform b [Homo sapiens]
Length = 759
Score = 129 bits (325), Expect = 4e-30
Identities = 64/182 (35%), Positives = 108/182 (59%), Gaps = 5/182 (2%)
Query: 298 VKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDS----QWEDIHVVTG 353
+++CI AVE RG++ G+YR+ G + +QKL ++ + + ++ +WE I +T
Sbjct: 393 IRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETDICAEWE-IKTITS 451
Query: 354 ALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHL 413
ALK + R LP PL Y F F++A K ++ +R+ + SLV +LP NR +++L HL
Sbjct: 452 ALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHL 511
Query: 414 TKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIFGSE 473
+ +NLM+ +LG+VFGPTLLR + ET + + +QN + E+++ + KIF +
Sbjct: 512 ANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTV 571
Query: 474 ED 475
D
Sbjct: 572 PD 573
>gi|7662208 GTPase regulator associated with the focal adhesion
kinase pp125 isoform a [Homo sapiens]
Length = 814
Score = 129 bits (325), Expect = 4e-30
Identities = 64/182 (35%), Positives = 108/182 (59%), Gaps = 5/182 (2%)
Query: 298 VKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDS----QWEDIHVVTG 353
+++CI AVE RG++ G+YR+ G + +QKL ++ + + ++ +WE I +T
Sbjct: 393 IRKCIHAVETRGINEQGLYRIVGVNSRVQKLLSVLMDPKTASETETDICAEWE-IKTITS 451
Query: 354 ALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHL 413
ALK + R LP PL Y F F++A K ++ +R+ + SLV +LP NR +++L HL
Sbjct: 452 ALKTYLRMLPGPLMMYQFQRSFIKAAKLENQESRVSEIHSLVHRLPEKNRQMLQLLMNHL 511
Query: 414 TKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIFGSE 473
+ +NLM+ +LG+VFGPTLLR + ET + + +QN + E+++ + KIF +
Sbjct: 512 ANVANNHKQNLMTVANLGVVFGPTLLRPQEETVAAIMDIKFQNIVIEILIENHEKIFNTV 571
Query: 474 ED 475
D
Sbjct: 572 PD 573
>gi|229094128 active breakpoint cluster region-related protein
isoform c [Homo sapiens]
Length = 813
Score = 129 bits (324), Expect = 6e-30
Identities = 79/202 (39%), Positives = 109/202 (53%), Gaps = 9/202 (4%)
Query: 243 SDTSDKNRVKSRLK-KFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQC 301
+D + N +K KF +R SLK K + +FG + V +RE S VP+ V+QC
Sbjct: 564 TDVIEMNGIKVEFSMKFTSRDMSLKRTPSKK--QTGVFGVKISVVTKRERSKVPYIVRQC 621
Query: 302 IEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEK---LNLDDSQWEDIHVVTGALKMF 358
+E VEKRG++ GIYR+SG IQ L+ + + K L L D DI+ + G LK++
Sbjct: 622 VEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDM---DINAIAGTLKLY 678
Query: 359 FRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVA 418
FRELPEPL + F+E I D + + L++ LP PN T L HL ++
Sbjct: 679 FRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAE 738
Query: 419 KASKNLMSTQSLGIVFGPTLLR 440
K N MS +L VFGPTLLR
Sbjct: 739 KEPINKMSLHNLATVFGPTLLR 760
>gi|38679957 active breakpoint cluster region-related protein
isoform a [Homo sapiens]
Length = 859
Score = 129 bits (324), Expect = 6e-30
Identities = 79/202 (39%), Positives = 109/202 (53%), Gaps = 9/202 (4%)
Query: 243 SDTSDKNRVKSRLK-KFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQC 301
+D + N +K KF +R SLK K + +FG + V +RE S VP+ V+QC
Sbjct: 610 TDVIEMNGIKVEFSMKFTSRDMSLKRTPSKK--QTGVFGVKISVVTKRERSKVPYIVRQC 667
Query: 302 IEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEK---LNLDDSQWEDIHVVTGALKMF 358
+E VEKRG++ GIYR+SG IQ L+ + + K L L D DI+ + G LK++
Sbjct: 668 VEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDM---DINAIAGTLKLY 724
Query: 359 FRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVA 418
FRELPEPL + F+E I D + + L++ LP PN T L HL ++
Sbjct: 725 FRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAE 784
Query: 419 KASKNLMSTQSLGIVFGPTLLR 440
K N MS +L VFGPTLLR
Sbjct: 785 KEPINKMSLHNLATVFGPTLLR 806
>gi|38679954 active breakpoint cluster region-related protein
isoform b [Homo sapiens]
Length = 822
Score = 129 bits (324), Expect = 6e-30
Identities = 79/202 (39%), Positives = 109/202 (53%), Gaps = 9/202 (4%)
Query: 243 SDTSDKNRVKSRLK-KFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQC 301
+D + N +K KF +R SLK K + +FG + V +RE S VP+ V+QC
Sbjct: 573 TDVIEMNGIKVEFSMKFTSRDMSLKRTPSKK--QTGVFGVKISVVTKRERSKVPYIVRQC 630
Query: 302 IEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEK---LNLDDSQWEDIHVVTGALKMF 358
+E VEKRG++ GIYR+SG IQ L+ + + K L L D DI+ + G LK++
Sbjct: 631 VEEVEKRGIEEVGIYRISGVATDIQALKAVFDANNKDILLMLSDM---DINAIAGTLKLY 687
Query: 359 FRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVA 418
FRELPEPL + F+E I D + + L++ LP PN T L HL ++
Sbjct: 688 FRELPEPLLTDRLYPAFMEGIALSDPAAKENCMMHLLRSLPDPNLITFLFLLEHLKRVAE 747
Query: 419 KASKNLMSTQSLGIVFGPTLLR 440
K N MS +L VFGPTLLR
Sbjct: 748 KEPINKMSLHNLATVFGPTLLR 769
>gi|4505507 oligophrenin 1 [Homo sapiens]
Length = 802
Score = 127 bits (320), Expect = 2e-29
Identities = 66/200 (33%), Positives = 118/200 (59%), Gaps = 5/200 (2%)
Query: 275 KDQIFGSHLHKVCERENSTVPW-FVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLR---F 330
K+ I+ S + K E E + V + FV++CI +E +G+ +G+YR G+ +QKL F
Sbjct: 366 KEPIYHSPITKQQEMELNEVGFKFVRKCINIIETKGIKTEGLYRTVGSNIQVQKLLNAFF 425
Query: 331 IVNQEEKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEA 390
++ +S W DI +T +LK + R L EP+ Y ++ V A K + + R+ A
Sbjct: 426 DPKCPGDVDFHNSDW-DIKTITSSLKFYLRNLSEPVMTYRLHKELVSAAKSDNLDYRLGA 484
Query: 391 VKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAI 450
+ SLV KLP NR+ +++L HL + + +NLM+ ++G++FGPTL+RA+ +T +
Sbjct: 485 IHSLVYKLPEKNREMLELLIRHLVNVCEHSKENLMTPSNMGVIFGPTLMRAQEDTVAAMM 544
Query: 451 HMVYQNQIAELMLSEYSKIF 470
++ +QN + E+++ + KI+
Sbjct: 545 NIKFQNIVVEILIEHFGKIY 564
>gi|50843948 Rho GTPase activating protein 10 [Homo sapiens]
Length = 786
Score = 127 bits (319), Expect = 2e-29
Identities = 63/181 (34%), Positives = 106/181 (58%), Gaps = 3/181 (1%)
Query: 298 VKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLN---LDDSQWEDIHVVTGA 354
+++CI AVE RG++ G+YRV G + +Q+L ++ + N L++S ++ +T A
Sbjct: 399 IRKCISAVETRGINDQGLYRVVGVSSKVQRLLSMLMDVKTCNEVDLENSADWEVKTITSA 458
Query: 355 LKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLT 414
LK + R LPEPL Y F+ K +R+ A+ LV KLP N++ + +L HLT
Sbjct: 459 LKQYLRSLPEPLMTYELHGDFIVPAKSGSPESRVNAIHFLVHKLPEKNKEMLDILVKHLT 518
Query: 415 KIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLSEYSKIFGSEE 474
+ + +NLM+ +LG+VFGPTL+R + ET + + +QN + E+++ + KIF +
Sbjct: 519 NVSNHSKQNLMTVANLGVVFGPTLMRPQEETVAALMDLKFQNIVVEILIENHEKIFRTPP 578
Query: 475 D 475
D
Sbjct: 579 D 579
>gi|82546845 breakpoint cluster region isoform 2 [Homo sapiens]
Length = 1227
Score = 125 bits (313), Expect = 1e-28
Identities = 73/194 (37%), Positives = 107/194 (55%), Gaps = 6/194 (3%)
Query: 257 KFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIY 316
KF +R SLK + + + +FG + V +RE S VP+ V+QC+E +E+RG++ GIY
Sbjct: 988 KFNSREFSLKRMPSRK--QTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIY 1045
Query: 317 RVSGNLATIQKLR--FIVNQEEKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQ 374
RVSG IQ L+ F VN ++ + D++ + G LK++FRELPEPLF F+
Sbjct: 1046 RVSGVATDIQALKAAFDVNNKDVSVMMSEM--DVNAIAGTLKLYFRELPEPLFTDEFYPN 1103
Query: 375 FVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVF 434
F E I D + + +L+ LP N T L HL ++ K + N MS +L VF
Sbjct: 1104 FAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVF 1163
Query: 435 GPTLLRAENETGNM 448
GPTLLR + +
Sbjct: 1164 GPTLLRPSEKESKL 1177
>gi|82546843 breakpoint cluster region isoform 1 [Homo sapiens]
Length = 1271
Score = 125 bits (313), Expect = 1e-28
Identities = 73/194 (37%), Positives = 107/194 (55%), Gaps = 6/194 (3%)
Query: 257 KFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIY 316
KF +R SLK + + + +FG + V +RE S VP+ V+QC+E +E+RG++ GIY
Sbjct: 1032 KFNSREFSLKRMPSRK--QTGVFGVKIAVVTKRERSKVPYIVRQCVEEIERRGMEEVGIY 1089
Query: 317 RVSGNLATIQKLR--FIVNQEEKLNLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQ 374
RVSG IQ L+ F VN ++ + D++ + G LK++FRELPEPLF F+
Sbjct: 1090 RVSGVATDIQALKAAFDVNNKDVSVMMSEM--DVNAIAGTLKLYFRELPEPLFTDEFYPN 1147
Query: 375 FVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVF 434
F E I D + + +L+ LP N T L HL ++ K + N MS +L VF
Sbjct: 1148 FAEGIALSDPVAKESCMLNLLLSLPEANLLTFLFLLDHLKRVAEKEAVNKMSLHNLATVF 1207
Query: 435 GPTLLRAENETGNM 448
GPTLLR + +
Sbjct: 1208 GPTLLRPSEKESKL 1221
>gi|23510413 sorting nexin 26 [Homo sapiens]
Length = 1126
Score = 124 bits (312), Expect = 1e-28
Identities = 72/230 (31%), Positives = 125/230 (54%), Gaps = 8/230 (3%)
Query: 248 KNRVKSRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEK 307
+ ++ L+ F+ RPS + L+++G+++ ++FG L + VP ++ C E +E
Sbjct: 282 RGKLAGLLRTFMRSRPSRQRLRQRGILRQRVFGCDLGEHLSNSGQDVPQVLRCCSEFIEA 341
Query: 308 RGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQW-EDIHVVTGALKMFFRELPEPL 366
G+ VDGIYR+SG + IQ+LR + E L + +DIH V+ K++FRELP PL
Sbjct: 342 HGV-VDGIYRLSGVSSNIQRLRHEFDSERIPELSGPAFLQDIHSVSSLCKLYFRELPNPL 400
Query: 367 FPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMS 426
Y + +F EA+ R+ V ++Q+LPPP+ T++ L HL ++ ++ M
Sbjct: 401 LTYQLYGKFSEAMSVPGEEERLVRVHDVIQQLPPPHYRTLEYLLRHLARMARHSANTSMH 460
Query: 427 TQSLGIVFGPTLLRA-ENETGNMAIHMVY-----QNQIAELMLSEYSKIF 470
++L IV+ P LLR+ E E+ M + Q+ + E +L+ +F
Sbjct: 461 ARNLAIVWAPNLLRSMELESVGMGGAAAFREVRVQSVVVEFLLTHVDVLF 510
>gi|218083800 Rho GTPase-activating protein isoform 1 [Homo sapiens]
Length = 2087
Score = 122 bits (307), Expect = 5e-28
Identities = 71/223 (31%), Positives = 124/223 (55%), Gaps = 8/223 (3%)
Query: 255 LKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDG 314
L+ F+ RP+ + L+++G++K+++FG L + VP ++ C +E+ G+ VDG
Sbjct: 346 LRTFMKSRPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGI-VDG 404
Query: 315 IYRVSGNLATIQKLRFIVNQEEKLNLDDSQW-EDIHVVTGALKMFFRELPEPLFPYSFFE 373
IYR+SG + IQ+LR + E +L + +DIH V K++FRELP PL Y +E
Sbjct: 405 IYRLSGVASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYE 464
Query: 374 QFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIV 433
+F +A+ + R+ + ++Q+LPPP+ T++ L HL+ + S M ++L IV
Sbjct: 465 KFSDAVSAATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIV 524
Query: 434 FGPTLLRAEN-----ETGNMAIHMV-YQNQIAELMLSEYSKIF 470
+ P LLR++ +G A V Q+ + E +L+ +F
Sbjct: 525 WAPNLLRSKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLF 567
>gi|150417981 glucocorticoid receptor DNA binding factor 1 [Homo
sapiens]
Length = 1499
Score = 122 bits (305), Expect = 9e-28
Identities = 71/227 (31%), Positives = 118/227 (51%), Gaps = 2/227 (0%)
Query: 239 HHSASDTSDKNRVKSRLKKFITRRPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFV 298
+ + D +N ++S + +P + K + FG L V E +P F+
Sbjct: 1207 YETDEDPRRRNILRSLRRNTKKPKPKPRPSITKATWESNYFGVPLTTVVTPEKP-IPIFI 1265
Query: 299 KQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKLNLDDSQWEDIHVVTGALKMF 358
++CIE +E GL +GIYRVSGN + ++ L+ +Q+ L+L + + ++ V GA+K F
Sbjct: 1266 ERCIEYIEATGLSTEGIYRVSGNKSEMESLQRQFDQDHNLDLAEKDFT-VNTVAGAMKSF 1324
Query: 359 FRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVA 418
F ELP+PL PY+ VEA K D ++ A+K +++K P N + K + HL K+
Sbjct: 1325 FSELPDPLVPYNMQIDLVEAHKINDREQKLHALKEVLKKFPKENHEVFKYVISHLNKVSH 1384
Query: 419 KASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQIAELMLSE 465
NLM++++L I F PTL+R + T + I EL + +
Sbjct: 1385 NNKVNLMTSENLSICFWPTLMRPDFSTMDALTATRTYQTIIELFIQQ 1431
>gi|71040096 Rho GTPase activating protein 30 isoform 2 [Homo
sapiens]
Length = 890
Score = 121 bits (304), Expect = 1e-27
Identities = 74/210 (35%), Positives = 117/210 (55%), Gaps = 8/210 (3%)
Query: 269 QEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKL 328
++KG K+++FG L + + VP +K C E VE+ G+ VDGIYR+SG + IQKL
Sbjct: 8 KKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNIQKL 66
Query: 329 RFIVNQEEKLNLD-DSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTR 387
R E K +L D +DIH V+ K +FRELP+PL Y +++F EA+ Q R
Sbjct: 67 RQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPER 126
Query: 388 IEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLR-----AE 442
+ + ++++LP PN T++ L HL + + +++ M ++L IV+ P LLR A
Sbjct: 127 LVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEAS 186
Query: 443 NETGNMAIHMV-YQNQIAELMLSEYSKIFG 471
G A V Q+ + E +L+ ++FG
Sbjct: 187 GFNGTAAFMEVRVQSIVVEFILTHVDQLFG 216
>gi|71040098 Rho GTPase activating protein 30 isoform 1 [Homo
sapiens]
Length = 1101
Score = 121 bits (304), Expect = 1e-27
Identities = 74/210 (35%), Positives = 117/210 (55%), Gaps = 8/210 (3%)
Query: 269 QEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKL 328
++KG K+++FG L + + VP +K C E VE+ G+ VDGIYR+SG + IQKL
Sbjct: 8 KKKGSAKERVFGCDLQEHLQHSGQEVPQVLKSCAEFVEEYGV-VDGIYRLSGVSSNIQKL 66
Query: 329 RFIVNQEEKLNLD-DSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTR 387
R E K +L D +DIH V+ K +FRELP+PL Y +++F EA+ Q R
Sbjct: 67 RQEFESERKPDLRRDVYLQDIHCVSSLCKAYFRELPDPLLTYRLYDKFAEAVGVQLEPER 126
Query: 388 IEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLR-----AE 442
+ + ++++LP PN T++ L HL + + +++ M ++L IV+ P LLR A
Sbjct: 127 LVKILEVLRELPVPNYRTLEFLMRHLVHMASFSAQTNMHARNLAIVWAPNLLRSKDIEAS 186
Query: 443 NETGNMAIHMV-YQNQIAELMLSEYSKIFG 471
G A V Q+ + E +L+ ++FG
Sbjct: 187 GFNGTAAFMEVRVQSIVVEFILTHVDQLFG 216
>gi|29469071 Rho GTPase-activating protein isoform 2 [Homo sapiens]
Length = 1738
Score = 119 bits (297), Expect = 8e-27
Identities = 69/216 (31%), Positives = 120/216 (55%), Gaps = 8/216 (3%)
Query: 262 RPSLKTLQEKGLIKDQIFGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGN 321
RP+ + L+++G++K+++FG L + VP ++ C +E+ G+ VDGIYR+SG
Sbjct: 4 RPTKQKLKQRGILKERVFGCDLGEHLLNSGFEVPQVLQSCTAFIERYGI-VDGIYRLSGV 62
Query: 322 LATIQKLRFIVNQEEKLNLDDSQW-EDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIK 380
+ IQ+LR + E +L + +DIH V K++FRELP PL Y +E+F +A+
Sbjct: 63 ASNIQRLRHEFDSEHVPDLTKEPYVQDIHSVGSLCKLYFRELPNPLLTYQLYEKFSDAVS 122
Query: 381 KQDNNTRIEAVKSLVQKLPPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLR 440
+ R+ + ++Q+LPPP+ T++ L HL+ + S M ++L IV+ P LLR
Sbjct: 123 AATDEERLIKIHDVIQQLPPPHYRTLEFLMRHLSLLADYCSITNMHAKNLAIVWAPNLLR 182
Query: 441 AEN-----ETGNMAIHMV-YQNQIAELMLSEYSKIF 470
++ +G A V Q+ + E +L+ +F
Sbjct: 183 SKQIESACFSGTAAFMEVRIQSVVVEFILNHVDVLF 218
>gi|71834863 Rho GTPase activating protein 5 isoform a [Homo sapiens]
Length = 1502
Score = 115 bits (289), Expect = 7e-26
Identities = 64/196 (32%), Positives = 101/196 (51%), Gaps = 2/196 (1%)
Query: 279 FGSHLHKVCERENSTVPWFVKQCIEAVEKRGLDVDGIYRVSGNLATIQKLRFIVNQEEKL 338
FG L + E +P FV++C+E +E GL +G+YRVSGN ++ +Q+ +
Sbjct: 1260 FGMPLQDLVTAEKP-IPLFVEKCVEFIEDTGLCTEGLYRVSGNKTDQDNIQKQFDQDHNI 1318
Query: 339 NLDDSQWEDIHVVTGALKMFFRELPEPLFPYSFFEQFVEAIKKQDNNTRIEAVKSLVQKL 398
NL + ++ V GALK FF +LP+PL PYS + +EA K D R+ A+K +V+K
Sbjct: 1319 NLVSME-VTVNAVAGALKAFFADLPDPLIPYSLHPELLEAAKIPDKTERLHALKEIVKKF 1377
Query: 399 PPPNRDTMKVLFGHLTKIVAKASKNLMSTQSLGIVFGPTLLRAENETGNMAIHMVYQNQI 458
P N D + + HL ++ + NLM+ +L I F PTL+R + E +
Sbjct: 1378 HPVNYDVFRYVITHLNRVSQQHKINLMTADNLSICFWPTLMRPDFENREFLSTTKIHQSV 1437
Query: 459 AELMLSEYSKIFGSEE 474
E + + F + E
Sbjct: 1438 VETFIQQCQFFFYNGE 1453
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.316 0.131 0.372
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 16,743,108
Number of Sequences: 37866
Number of extensions: 701687
Number of successful extensions: 2884
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 109
Number of HSP's successfully gapped in prelim test: 41
Number of HSP's that attempted gapping in prelim test: 2591
Number of HSP's gapped (non-prelim): 181
length of query: 475
length of database: 18,247,518
effective HSP length: 106
effective length of query: 369
effective length of database: 14,233,722
effective search space: 5252243418
effective search space used: 5252243418
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.