Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 187960100
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
(1083 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|187960100 ubiquitin protein ligase E3C [Homo sapiens] 2155 0.0
gi|35493952 ubiquitin protein ligase E3B [Homo sapiens] 345 1e-94
gi|35493959 ubiquitin protein ligase E3B [Homo sapiens] 345 1e-94
gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens] 197 4e-50
gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens] 197 4e-50
gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens] 197 4e-50
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens] 188 3e-47
gi|222352183 neural precursor cell expressed, developmentally do... 187 4e-47
gi|21361472 neural precursor cell expressed, developmentally dow... 187 4e-47
gi|222352094 neural precursor cell expressed, developmentally do... 187 4e-47
gi|222352092 neural precursor cell expressed, developmentally do... 187 4e-47
gi|222352090 neural precursor cell expressed, developmentally do... 187 4e-47
gi|222352088 neural precursor cell expressed, developmentally do... 187 4e-47
gi|222352086 neural precursor cell expressed, developmentally do... 187 4e-47
gi|222352084 neural precursor cell expressed, developmentally do... 187 4e-47
gi|222352082 neural precursor cell expressed, developmentally do... 187 4e-47
gi|114520609 neural precursor cell expressed, developmentally do... 184 3e-46
gi|114520607 neural precursor cell expressed, developmentally do... 184 3e-46
gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiqu... 183 7e-46
gi|40806211 WW domain containing E3 ubiquitin protein ligase 2 i... 178 2e-44
gi|40806207 WW domain containing E3 ubiquitin protein ligase 2 i... 178 2e-44
gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [H... 176 8e-44
gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [H... 176 8e-44
gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin prote... 175 2e-43
gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [... 170 8e-42
gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo sa... 169 1e-41
gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapi... 167 5e-41
gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens] 167 5e-41
gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens] 167 5e-41
gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens] 164 3e-40
>gi|187960100 ubiquitin protein ligase E3C [Homo sapiens]
Length = 1083
Score = 2155 bits (5584), Expect = 0.0
Identities = 1083/1083 (100%), Positives = 1083/1083 (100%)
Query: 1 MFSFEGDFKTRPKVSLGGASRKEEKASLLHRTQEERRKREEERRRLKNAIIIQSFIRGYR 60
MFSFEGDFKTRPKVSLGGASRKEEKASLLHRTQEERRKREEERRRLKNAIIIQSFIRGYR
Sbjct: 1 MFSFEGDFKTRPKVSLGGASRKEEKASLLHRTQEERRKREEERRRLKNAIIIQSFIRGYR 60
Query: 61 DRKQQYSIQRSAFDRCATLSQSGGAFPIANGPNLTLLVRQLLFFYKQNEDSKRLIWLYQN 120
DRKQQYSIQRSAFDRCATLSQSGGAFPIANGPNLTLLVRQLLFFYKQNEDSKRLIWLYQN
Sbjct: 61 DRKQQYSIQRSAFDRCATLSQSGGAFPIANGPNLTLLVRQLLFFYKQNEDSKRLIWLYQN 120
Query: 121 LIKHSSLFVKQLDGSERLTCLFQIKRLMSLCCRLLQNCNDDSLNVALPMRMLEVFSSENT 180
LIKHSSLFVKQLDGSERLTCLFQIKRLMSLCCRLLQNCNDDSLNVALPMRMLEVFSSENT
Sbjct: 121 LIKHSSLFVKQLDGSERLTCLFQIKRLMSLCCRLLQNCNDDSLNVALPMRMLEVFSSENT 180
Query: 181 YLPVLQDASYVVSVIEQILHYMIHNGYYRSLYLLINSKLPSSIEYSDLSRVPIAKILLEN 240
YLPVLQDASYVVSVIEQILHYMIHNGYYRSLYLLINSKLPSSIEYSDLSRVPIAKILLEN
Sbjct: 181 YLPVLQDASYVVSVIEQILHYMIHNGYYRSLYLLINSKLPSSIEYSDLSRVPIAKILLEN 240
Query: 241 VLKPLHFTYNSCPEGARQQVFTAFTEEFLAAPFTDQIFHFIIPALADAQTVFPYEPFLNA 300
VLKPLHFTYNSCPEGARQQVFTAFTEEFLAAPFTDQIFHFIIPALADAQTVFPYEPFLNA
Sbjct: 241 VLKPLHFTYNSCPEGARQQVFTAFTEEFLAAPFTDQIFHFIIPALADAQTVFPYEPFLNA 300
Query: 301 LLLIESRCSRKSGGAPWLFYFVLTVGENYLGALSEEGLLVYLRVLQTFLSQLPVSPASAS 360
LLLIESRCSRKSGGAPWLFYFVLTVGENYLGALSEEGLLVYLRVLQTFLSQLPVSPASAS
Sbjct: 301 LLLIESRCSRKSGGAPWLFYFVLTVGENYLGALSEEGLLVYLRVLQTFLSQLPVSPASAS 360
Query: 361 CHDSASDSEEESEEADKPSSPEDGRLSVSYITEECLKKLDTKQQTNTLLNLVWRDSASEE 420
CHDSASDSEEESEEADKPSSPEDGRLSVSYITEECLKKLDTKQQTNTLLNLVWRDSASEE
Sbjct: 361 CHDSASDSEEESEEADKPSSPEDGRLSVSYITEECLKKLDTKQQTNTLLNLVWRDSASEE 420
Query: 421 VFTTMASVCHTLMVQHRMMVPKVRLLYSLAFNARFLRHLWFLISSMSTRMITGSMVPLLQ 480
VFTTMASVCHTLMVQHRMMVPKVRLLYSLAFNARFLRHLWFLISSMSTRMITGSMVPLLQ
Sbjct: 421 VFTTMASVCHTLMVQHRMMVPKVRLLYSLAFNARFLRHLWFLISSMSTRMITGSMVPLLQ 480
Query: 481 VISRGSPMSFEDSSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQSSMMPFTLE 540
VISRGSPMSFEDSSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQSSMMPFTLE
Sbjct: 481 VISRGSPMSFEDSSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQSSMMPFTLE 540
Query: 541 ELIMLSRCLRDACLGIIKLAYPETKPEVREEYITAFQSIGVTTSSEMQQCIQMEQKRWIQ 600
ELIMLSRCLRDACLGIIKLAYPETKPEVREEYITAFQSIGVTTSSEMQQCIQMEQKRWIQ
Sbjct: 541 ELIMLSRCLRDACLGIIKLAYPETKPEVREEYITAFQSIGVTTSSEMQQCIQMEQKRWIQ 600
Query: 601 LFKVITNLVKMLKSRDTRRNFCPPNHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIG 660
LFKVITNLVKMLKSRDTRRNFCPPNHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIG
Sbjct: 601 LFKVITNLVKMLKSRDTRRNFCPPNHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIG 660
Query: 661 PLQSTLDVGLESPPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFL 720
PLQSTLDVGLESPPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFL
Sbjct: 661 PLQSTLDVGLESPPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFL 720
Query: 721 DGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNEL 780
DGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNEL
Sbjct: 721 DGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNEL 780
Query: 781 LKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFA 840
LKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFA
Sbjct: 781 LKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFA 840
Query: 841 GFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVV 900
GFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVV
Sbjct: 841 GFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVV 900
Query: 901 ELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEI 960
ELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEI
Sbjct: 901 ELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEI 960
Query: 961 QVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSR 1020
QVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSR
Sbjct: 961 QVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSR 1020
Query: 1021 PPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGF 1080
PPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGF
Sbjct: 1021 PPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGF 1080
Query: 1081 ELS 1083
ELS
Sbjct: 1081 ELS 1083
>gi|35493952 ubiquitin protein ligase E3B [Homo sapiens]
Length = 1068
Score = 345 bits (886), Expect = 1e-94
Identities = 319/1163 (27%), Positives = 513/1163 (44%), Gaps = 207/1163 (17%)
Query: 25 KASLLHRTQEERRKREEERRRLKNAIIIQSFIRGYRDRKQ-QYSIQRSAFDRCATLSQSG 83
+A + R ++ R +R ++ R + A++IQ+ +R + R + Q I+R D
Sbjct: 9 RAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDD--------- 59
Query: 84 GAFPIANGPNLTL--------LVRQLLFFYKQNEDSKRLIWLYQNLI------KHSSLFV 129
F A+ P T + R+LLF ++ ED++R L ++++ ++
Sbjct: 60 --FFKADDPESTKRSALCIFKIARKLLFLFRIKEDNERFEKLCRSILSSMDAENEPKVWY 117
Query: 130 KQLDGSERLTCLF--QIKRLMSLCCRLLQNCN----DDSLNVALPMRMLEVFSSENTYLP 183
L S+ LT L+ QIK ++ CC L+ DS + L + ML F+ +T+
Sbjct: 118 VSLACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTW-K 176
Query: 184 VLQDASYVV-----SVIEQILHYMIHNGYYRSLYLLIN----------SKLPSSIEYSDL 228
+L+ + + I+ ++ +G+Y L +L+ SK + +S
Sbjct: 177 ILRGKGESLRPAMNHICANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLA 236
Query: 229 SRVPIAKILLENVLKPLHFTYNSCPEGARQQVFTAFTEEFLAAPFTDQIFHFII------ 282
R IA +N+++P S P + T E D + FII
Sbjct: 237 LRPVIAAQFSDNLIRPFLIHIMSVP-ALVTHLSTVTPERLTVLESHDMLRKFIIFLRDQD 295
Query: 283 ------PALADAQTVFPYEPFLNALLLIESRCSRKSGGAPWLFYFVLTVGENYLGALSEE 336
+L T+ L+ L ++ G L L Y+ ++
Sbjct: 296 RCRDVCESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLLTQTLCYCRKYVS--QKK 353
Query: 337 GLLVYLRVLQTFLSQLPVSPASASCH--------------------DSASDSEEESEEA- 375
L + + + SQ + S H D S ES+E
Sbjct: 354 SNLTHWHPVLGWFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCDILSKKLLESQEPA 413
Query: 376 -DKPSSPEDGRLSVSYITEECLKKLDTKQQTNTLLNLVWRDSASEEVFTTMASVCHTLMV 434
+P+SP++ L V + + +K +L V + ++C L
Sbjct: 414 HAQPASPQN-VLPVKSLLKRAFQK---SASVRNILRPVGGKRVDSAEVQKVCNIC-VLYQ 468
Query: 435 QHRMMVPKVRL--LYSLAFNARFLRHLWFLISSMSTRMITGSMVPLLQVISRGSPMSFED 492
+ ++RL L L + L LW I + G + L+ ++ + E+
Sbjct: 469 TSLTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPH---GGLKLFLECLNNDT----EE 521
Query: 493 SSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQSSMMPFTLEELIMLSRCLRDA 552
S +++ + LF H + + D E + + I F LEEL+ +S L
Sbjct: 522 SKQLLAMLMLFCDCSRHLITILDDIEVYEEQIS-----------FKLEELVTISSFLNSF 570
Query: 553 CLGIIKLAYPETKPEVREEYITAFQSIGVTTSSEMQQCIQMEQKRWIQLFKVITNLVKML 612
+ K+ + + E + FQS+ W+ +L
Sbjct: 571 ---VFKMIWDGIVENAKGETLELFQSV----------------HGWLM----------VL 601
Query: 613 KSRDTRRNFCPPNHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQSTLDVGLES 672
RD RR F P +HWL ++D+K + Q
Sbjct: 602 YERDCRRRFTPEDHWL--RKDLKPSVLFQ------------------------------- 628
Query: 673 PPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIYADKQE---VQGDGPFLDGINVTIRR 729
L +R +L +P V+P + RV +F+ ++ +K++ V+ ++TIRR
Sbjct: 629 -ELDRDRKRAQLILQYIPHVIPHKNRVLLFRTMVTKEKEKLGLVETSSASPHVTHITIRR 687
Query: 730 NYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQ 789
+ + ED Y++L ++ +K IRV +N G+DEAGID G+F+EFL E++K F+P
Sbjct: 688 SRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPAL 747
Query: 790 GFFKTTN-EGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLL 848
FKTT+ + LYP+P + + +++ + + F+G+MLGKA+YE ++V++PFA FFLS+LL
Sbjct: 748 NLFKTTSGDERLYPSPTS--YIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLL 805
Query: 849 GTSADV---DIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFG 905
G V + L SLD E YKNL +K Y+ D+ +LGL + + +G+ EL G
Sbjct: 806 GHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVCHELIPG 865
Query: 906 GKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLIS 965
GK IPVT+ N+I+YIHL+A +R++ QI+ A G +++ EW+RMF E+Q LIS
Sbjct: 866 GKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLIS 925
Query: 966 GAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVV-EGFTDEEKRKLLKFVTSCSRPPLL 1024
G I LEDLK T Y GG+ H VI W ++ FT +E+ LKFVTSCSRPPLL
Sbjct: 926 GDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSCSRPPLL 985
Query: 1025 GFKELYPAFCIH------------NGGSDLE------------RLPTASTCMNLLKLPEF 1060
GF L P F I GS L RLPT+STC NLLKLP +
Sbjct: 986 GFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNY 1045
Query: 1061 YDETLLRSKLLYAIECAAGFELS 1083
+++LR KL YAI GFELS
Sbjct: 1046 SKKSVLREKLRYAISMNTGFELS 1068
>gi|35493959 ubiquitin protein ligase E3B [Homo sapiens]
Length = 1068
Score = 345 bits (886), Expect = 1e-94
Identities = 319/1163 (27%), Positives = 513/1163 (44%), Gaps = 207/1163 (17%)
Query: 25 KASLLHRTQEERRKREEERRRLKNAIIIQSFIRGYRDRKQ-QYSIQRSAFDRCATLSQSG 83
+A + R ++ R +R ++ R + A++IQ+ +R + R + Q I+R D
Sbjct: 9 RAWFIDRARQAREERLVQKERERAAVVIQAHVRSFLCRSRLQRDIRREIDD--------- 59
Query: 84 GAFPIANGPNLTL--------LVRQLLFFYKQNEDSKRLIWLYQNLI------KHSSLFV 129
F A+ P T + R+LLF ++ ED++R L ++++ ++
Sbjct: 60 --FFKADDPESTKRSALCIFKIARKLLFLFRIKEDNERFEKLCRSILSSMDAENEPKVWY 117
Query: 130 KQLDGSERLTCLF--QIKRLMSLCCRLLQNCN----DDSLNVALPMRMLEVFSSENTYLP 183
L S+ LT L+ QIK ++ CC L+ DS + L + ML F+ +T+
Sbjct: 118 VSLACSKDLTLLWIQQIKNILWYCCDFLKQLKPEILQDSRLITLYLTMLVTFTDTSTW-K 176
Query: 184 VLQDASYVV-----SVIEQILHYMIHNGYYRSLYLLIN----------SKLPSSIEYSDL 228
+L+ + + I+ ++ +G+Y L +L+ SK + +S
Sbjct: 177 ILRGKGESLRPAMNHICANIMGHLNQHGFYSVLQILLTRGLARPRPCLSKGTLTAAFSLA 236
Query: 229 SRVPIAKILLENVLKPLHFTYNSCPEGARQQVFTAFTEEFLAAPFTDQIFHFII------ 282
R IA +N+++P S P + T E D + FII
Sbjct: 237 LRPVIAAQFSDNLIRPFLIHIMSVP-ALVTHLSTVTPERLTVLESHDMLRKFIIFLRDQD 295
Query: 283 ------PALADAQTVFPYEPFLNALLLIESRCSRKSGGAPWLFYFVLTVGENYLGALSEE 336
+L T+ L+ L ++ G L L Y+ ++
Sbjct: 296 RCRDVCESLEGCHTLCLMGNLLHLGSLSPRVLEEETDGFVSLLTQTLCYCRKYVS--QKK 353
Query: 337 GLLVYLRVLQTFLSQLPVSPASASCH--------------------DSASDSEEESEEA- 375
L + + + SQ + S H D S ES+E
Sbjct: 354 SNLTHWHPVLGWFSQSVDYGLNESMHLITKQLQFLWGVPLIRIFFCDILSKKLLESQEPA 413
Query: 376 -DKPSSPEDGRLSVSYITEECLKKLDTKQQTNTLLNLVWRDSASEEVFTTMASVCHTLMV 434
+P+SP++ L V + + +K +L V + ++C L
Sbjct: 414 HAQPASPQN-VLPVKSLLKRAFQK---SASVRNILRPVGGKRVDSAEVQKVCNIC-VLYQ 468
Query: 435 QHRMMVPKVRL--LYSLAFNARFLRHLWFLISSMSTRMITGSMVPLLQVISRGSPMSFED 492
+ ++RL L L + L LW I + G + L+ ++ + E+
Sbjct: 469 TSLTTLTQIRLQILTGLTYLDDLLPKLWAFICELGPH---GGLKLFLECLNNDT----EE 521
Query: 493 SSRIIPLFYLFSSLFSHSLISIHDNEFFGDPIEVVGQRQSSMMPFTLEELIMLSRCLRDA 552
S +++ + LF H + + D E + + I F LEEL+ +S L
Sbjct: 522 SKQLLAMLMLFCDCSRHLITILDDIEVYEEQIS-----------FKLEELVTISSFLNSF 570
Query: 553 CLGIIKLAYPETKPEVREEYITAFQSIGVTTSSEMQQCIQMEQKRWIQLFKVITNLVKML 612
+ K+ + + E + FQS+ W+ +L
Sbjct: 571 ---VFKMIWDGIVENAKGETLELFQSV----------------HGWLM----------VL 601
Query: 613 KSRDTRRNFCPPNHWLSEQEDIKADKVTQLYVPASRHVWRFRRMGRIGPLQSTLDVGLES 672
RD RR F P +HWL ++D+K + Q
Sbjct: 602 YERDCRRRFTPEDHWL--RKDLKPSVLFQ------------------------------- 628
Query: 673 PPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIYADKQE---VQGDGPFLDGINVTIRR 729
L +R +L +P V+P + RV +F+ ++ +K++ V+ ++TIRR
Sbjct: 629 -ELDRDRKRAQLILQYIPHVIPHKNRVLLFRTMVTKEKEKLGLVETSSASPHVTHITIRR 687
Query: 730 NYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQ 789
+ + ED Y++L ++ +K IRV +N G+DEAGID G+F+EFL E++K F+P
Sbjct: 688 SRMLEDGYEQLRQLSQHAMKGVIRVKFVNDLGVDEAGIDQDGVFKEFLEEIIKRVFDPAL 747
Query: 790 GFFKTTN-EGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLL 848
FKTT+ + LYP+P + + +++ + + F+G+MLGKA+YE ++V++PFA FFLS+LL
Sbjct: 748 NLFKTTSGDERLYPSPTS--YIHENYLQLFEFVGKMLGKAVYEGIVVDVPFASFFLSQLL 805
Query: 849 GTSADV---DIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFG 905
G V + L SLD E YKNL +K Y+ D+ +LGL + + +G+ EL G
Sbjct: 806 GHHHSVFYSSVDELPSLDSEFYKNLTSIKRYDGDITDLGLTLSYDEDVMGQLVCHELIPG 865
Query: 906 GKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLIS 965
GK IPVT+ N+I+YIHL+A +R++ QI+ A G +++ EW+RMF E+Q LIS
Sbjct: 866 GKTIPVTNENKISYIHLMAHFRMHTQIKNQTAALISGFRSIIKPEWIRMFSTPELQRLIS 925
Query: 966 GAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVV-EGFTDEEKRKLLKFVTSCSRPPLL 1024
G I LEDLK T Y GG+ H VI W ++ FT +E+ LKFVTSCSRPPLL
Sbjct: 926 GDNAEIDLEDLKKHTVYYGGFHGSHRVIIWLWDILASDFTPDERAMFLKFVTSCSRPPLL 985
Query: 1025 GFKELYPAFCIH------------NGGSDLE------------RLPTASTCMNLLKLPEF 1060
GF L P F I GS L RLPT+STC NLLKLP +
Sbjct: 986 GFAYLKPPFSIRCVEVSDDQDTGDTLGSVLRGFFTIRKREPGGRLPTSSTCFNLLKLPNY 1045
Query: 1061 YDETLLRSKLLYAIECAAGFELS 1083
+++LR KL YAI GFELS
Sbjct: 1046 SKKSVLREKLRYAISMNTGFELS 1068
>gi|19718764 ubiquitin protein ligase E3A isoform 3 [Homo sapiens]
Length = 872
Score = 197 bits (501), Expect = 4e-50
Identities = 142/440 (32%), Positives = 232/440 (52%), Gaps = 40/440 (9%)
Query: 661 PLQSTLDVGLESPPLSVSEERQLAVLTELPFVVP---------FEERVKIF-QRLIYADK 710
PL L++ + V E + + +T PF++ ++ R++++ +R I
Sbjct: 450 PLNEVLEMDKDYTFFKVETENKFSFMT-CPFILNAVTKNLGLYYDNRIRMYSERRITVLY 508
Query: 711 QEVQGD--GPFLDGINVTIRRNYIYEDAYDKL---SPENEPDLKKRIRVHLLNAHGLDEA 765
VQG P+L + +RR++I +DA +L + EN DLKK++ V G+DE
Sbjct: 509 SLVQGQQLNPYL---RLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDE- 564
Query: 766 GIDGGGIFREFLNELLKSGFNPNQGFFKTTNEG--LLYPNPAAQMLVGDSFARHYYFLGR 823
GG+ +EF +++ FNP+ G F T +E L + NP++ G + +G
Sbjct: 565 ----GGVSKEFFQLVVEEIFNPDIGMF-TYDESTKLFWFNPSSFETEGQ-----FTLIGI 614
Query: 824 MLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEE- 882
+LG A+Y N ++++ F KL+G L P +Y++L L YE +VE+
Sbjct: 615 VLGLAIYNNCILDVHFPMVVYRKLMGKKGT--FRDLGDSHPVLYQSLKDLLEYEGNVEDD 672
Query: 883 LGLNFTVVNNDL-GEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQ 941
+ + F + DL G + +LK G IP+T+ NR +++L +DY LN+ + + AFR+
Sbjct: 673 MMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRR 732
Query: 942 GLANVVSLEWLR-MFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVV 1000
G V + L+ +F +EI++LI G++ + + L+ T Y GGY+ D +I+ FW +V
Sbjct: 733 GFHMVTNESPLKYLFRPEEIELLICGSR-NLDFQALEETTEYDGGYTRDSVLIREFWEIV 791
Query: 1001 EGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEF 1060
FTDE+KR L+F T R P+ G +L I G D ERLPT+ TC N+L LPE+
Sbjct: 792 HSFTDEQKRLFLQFTTGTDRAPVGGLGKL--KMIIAKNGPDTERLPTSHTCFNVLLLPEY 849
Query: 1061 YDETLLRSKLLYAIECAAGF 1080
+ L+ +LL AI A GF
Sbjct: 850 SSKEKLKERLLKAITYAKGF 869
>gi|19718762 ubiquitin protein ligase E3A isoform 1 [Homo sapiens]
Length = 852
Score = 197 bits (501), Expect = 4e-50
Identities = 142/440 (32%), Positives = 232/440 (52%), Gaps = 40/440 (9%)
Query: 661 PLQSTLDVGLESPPLSVSEERQLAVLTELPFVVP---------FEERVKIF-QRLIYADK 710
PL L++ + V E + + +T PF++ ++ R++++ +R I
Sbjct: 430 PLNEVLEMDKDYTFFKVETENKFSFMT-CPFILNAVTKNLGLYYDNRIRMYSERRITVLY 488
Query: 711 QEVQGD--GPFLDGINVTIRRNYIYEDAYDKL---SPENEPDLKKRIRVHLLNAHGLDEA 765
VQG P+L + +RR++I +DA +L + EN DLKK++ V G+DE
Sbjct: 489 SLVQGQQLNPYL---RLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDE- 544
Query: 766 GIDGGGIFREFLNELLKSGFNPNQGFFKTTNEG--LLYPNPAAQMLVGDSFARHYYFLGR 823
GG+ +EF +++ FNP+ G F T +E L + NP++ G + +G
Sbjct: 545 ----GGVSKEFFQLVVEEIFNPDIGMF-TYDESTKLFWFNPSSFETEGQ-----FTLIGI 594
Query: 824 MLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEE- 882
+LG A+Y N ++++ F KL+G L P +Y++L L YE +VE+
Sbjct: 595 VLGLAIYNNCILDVHFPMVVYRKLMGKKGT--FRDLGDSHPVLYQSLKDLLEYEGNVEDD 652
Query: 883 LGLNFTVVNNDL-GEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQ 941
+ + F + DL G + +LK G IP+T+ NR +++L +DY LN+ + + AFR+
Sbjct: 653 MMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRR 712
Query: 942 GLANVVSLEWLR-MFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVV 1000
G V + L+ +F +EI++LI G++ + + L+ T Y GGY+ D +I+ FW +V
Sbjct: 713 GFHMVTNESPLKYLFRPEEIELLICGSR-NLDFQALEETTEYDGGYTRDSVLIREFWEIV 771
Query: 1001 EGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEF 1060
FTDE+KR L+F T R P+ G +L I G D ERLPT+ TC N+L LPE+
Sbjct: 772 HSFTDEQKRLFLQFTTGTDRAPVGGLGKL--KMIIAKNGPDTERLPTSHTCFNVLLLPEY 829
Query: 1061 YDETLLRSKLLYAIECAAGF 1080
+ L+ +LL AI A GF
Sbjct: 830 SSKEKLKERLLKAITYAKGF 849
>gi|19718766 ubiquitin protein ligase E3A isoform 2 [Homo sapiens]
Length = 875
Score = 197 bits (501), Expect = 4e-50
Identities = 142/440 (32%), Positives = 232/440 (52%), Gaps = 40/440 (9%)
Query: 661 PLQSTLDVGLESPPLSVSEERQLAVLTELPFVVP---------FEERVKIF-QRLIYADK 710
PL L++ + V E + + +T PF++ ++ R++++ +R I
Sbjct: 453 PLNEVLEMDKDYTFFKVETENKFSFMT-CPFILNAVTKNLGLYYDNRIRMYSERRITVLY 511
Query: 711 QEVQGD--GPFLDGINVTIRRNYIYEDAYDKL---SPENEPDLKKRIRVHLLNAHGLDEA 765
VQG P+L + +RR++I +DA +L + EN DLKK++ V G+DE
Sbjct: 512 SLVQGQQLNPYL---RLKVRRDHIIDDALVRLEMIAMENPADLKKQLYVEFEGEQGVDE- 567
Query: 766 GIDGGGIFREFLNELLKSGFNPNQGFFKTTNEG--LLYPNPAAQMLVGDSFARHYYFLGR 823
GG+ +EF +++ FNP+ G F T +E L + NP++ G + +G
Sbjct: 568 ----GGVSKEFFQLVVEEIFNPDIGMF-TYDESTKLFWFNPSSFETEGQ-----FTLIGI 617
Query: 824 MLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEE- 882
+LG A+Y N ++++ F KL+G L P +Y++L L YE +VE+
Sbjct: 618 VLGLAIYNNCILDVHFPMVVYRKLMGKKGT--FRDLGDSHPVLYQSLKDLLEYEGNVEDD 675
Query: 883 LGLNFTVVNNDL-GEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQ 941
+ + F + DL G + +LK G IP+T+ NR +++L +DY LN+ + + AFR+
Sbjct: 676 MMITFQISQTDLFGNPMMYDLKENGDKIPITNENRKEFVNLYSDYILNKSVEKQFKAFRR 735
Query: 942 GLANVVSLEWLR-MFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVV 1000
G V + L+ +F +EI++LI G++ + + L+ T Y GGY+ D +I+ FW +V
Sbjct: 736 GFHMVTNESPLKYLFRPEEIELLICGSR-NLDFQALEETTEYDGGYTRDSVLIREFWEIV 794
Query: 1001 EGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEF 1060
FTDE+KR L+F T R P+ G +L I G D ERLPT+ TC N+L LPE+
Sbjct: 795 HSFTDEQKRLFLQFTTGTDRAPVGGLGKL--KMIIAKNGPDTERLPTSHTCFNVLLLPEY 852
Query: 1061 YDETLLRSKLLYAIECAAGF 1080
+ L+ +LL AI A GF
Sbjct: 853 SSKEKLKERLLKAITYAKGF 872
>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
Length = 4374
Score = 188 bits (477), Expect = 3e-47
Identities = 134/410 (32%), Positives = 215/410 (52%), Gaps = 28/410 (6%)
Query: 684 AVLTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPE 743
AVL + V+ F+ + K F++ + E +G + + V +RR++++ED+Y +L +
Sbjct: 3983 AVLVDYIRVLDFDVKRKYFRQEL-----ERLDEGLRKEDMAVHVRRDHVFEDSYRELHRK 4037
Query: 744 NEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTT-NEGLLYP 802
+ ++K R+ + E G D GG+ RE+ + + FNP F+T+ + + Y
Sbjct: 4038 SPEEMKNRLYIVFEG-----EEGQDAGGLLREWYMIISREMFNPMYALFRTSPGDRVTYT 4092
Query: 803 -NPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLAS 861
NP++ + ++ F+GR++ KA+Y+N L+E F F +LG S V + S
Sbjct: 4093 INPSSHC--NPNHLSYFKFVGRIVAKAVYDNRLLECYFTRSFYKHILGKS--VRYTDMES 4148
Query: 862 LDPEVYKNLLFLKSYEDDVEELG--LNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAY 919
D Y+ L++L E+DV LG L F+ + G +V +LK G +I VT N+ Y
Sbjct: 4149 EDYHFYQGLVYL--LENDVSTLGYDLTFSTEVQEFGVCEVRDLKPNGANILVTEENKKEY 4206
Query: 920 IHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSF 979
+HLV R+ IR+ AF +G ++ + +F +QE+++LISG I ++DLKS
Sbjct: 4207 VHLVCQMRMTGAIRKQLAAFLEGFYEIIPKRLISIFTEQELELLISGLPT-IDIDDLKSN 4265
Query: 980 TNYSGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKEL-----YPAFC 1034
T Y Y ++ I+ FWR + F ++ K L+FVT S+ PL GF L F
Sbjct: 4266 TEYH-KYQSNSIQIQWFWRALRSFDQADRAKFLQFVTGTSKVPLQGFAALEGMNGIQKFQ 4324
Query: 1035 IHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAI-ECAAGFELS 1083
IH +RLP+A TC N L LP + LR LL AI EC+ GF L+
Sbjct: 4325 IHRDDRSTDRLPSAHTCFNQLDLPAYESFEKLRHMLLLAIQECSEGFGLA 4374
>gi|222352183 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 187 bits (476), Expect = 4e-47
Identities = 128/401 (31%), Positives = 214/401 (53%), Gaps = 27/401 (6%)
Query: 689 LPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPD- 747
+P+ F+++ F++ K + D P + + + RN I+E++Y ++ PD
Sbjct: 470 VPYSREFKQKYDYFRK-----KLKKPADIP--NRFEMKLHRNNIFEESYRRIMSVKRPDV 522
Query: 748 LKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFK--TTNEGLLYPNPA 805
LK R+ + + E G+D GG+ RE+ L K FNP G F+ T+ L NP
Sbjct: 523 LKARLWIEFES-----EKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPN 577
Query: 806 AQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPE 865
+ + D + ++ F+GR+ G A++ L++ F F +LG + ++ + S+D E
Sbjct: 578 SGLCNEDHLS-YFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQ--ITLNDMESVDSE 634
Query: 866 VYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVAD 925
Y +L ++ E+D EL L F + + G+ V+LK G +I VT+ N+ YI LV
Sbjct: 635 YYNSLKWI--LENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 692
Query: 926 YRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGG 985
+R ++++ AF +G ++ ++ +++FD+ E+++L+ G + + D + + Y G
Sbjct: 693 WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLG-DVDVNDWRQHSIYKNG 751
Query: 986 YSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPA-----FCIHNGGS 1040
Y +HPVI+ FW+ V E++ +LL+FVT SR P+ GF ELY + F I GS
Sbjct: 752 YCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS 811
Query: 1041 DLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFE 1081
E+LP A TC N L LP + LR KLL A+E A GFE
Sbjct: 812 P-EKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 851
>gi|21361472 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 3 [Homo sapiens]
Length = 955
Score = 187 bits (476), Expect = 4e-47
Identities = 128/401 (31%), Positives = 214/401 (53%), Gaps = 27/401 (6%)
Query: 689 LPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPD- 747
+P+ F+++ F++ K + D P + + + RN I+E++Y ++ PD
Sbjct: 571 VPYSREFKQKYDYFRK-----KLKKPADIP--NRFEMKLHRNNIFEESYRRIMSVKRPDV 623
Query: 748 LKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFK--TTNEGLLYPNPA 805
LK R+ + + E G+D GG+ RE+ L K FNP G F+ T+ L NP
Sbjct: 624 LKARLWIEFES-----EKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPN 678
Query: 806 AQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPE 865
+ + D + ++ F+GR+ G A++ L++ F F +LG + ++ + S+D E
Sbjct: 679 SGLCNEDHLS-YFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQ--ITLNDMESVDSE 735
Query: 866 VYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVAD 925
Y +L ++ E+D EL L F + + G+ V+LK G +I VT+ N+ YI LV
Sbjct: 736 YYNSLKWI--LENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 793
Query: 926 YRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGG 985
+R ++++ AF +G ++ ++ +++FD+ E+++L+ G + + D + + Y G
Sbjct: 794 WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLG-DVDVNDWRQHSIYKNG 852
Query: 986 YSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPA-----FCIHNGGS 1040
Y +HPVI+ FW+ V E++ +LL+FVT SR P+ GF ELY + F I GS
Sbjct: 853 YCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS 912
Query: 1041 DLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFE 1081
E+LP A TC N L LP + LR KLL A+E A GFE
Sbjct: 913 P-EKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 952
>gi|222352094 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 187 bits (476), Expect = 4e-47
Identities = 128/401 (31%), Positives = 214/401 (53%), Gaps = 27/401 (6%)
Query: 689 LPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPD- 747
+P+ F+++ F++ K + D P + + + RN I+E++Y ++ PD
Sbjct: 450 VPYSREFKQKYDYFRK-----KLKKPADIP--NRFEMKLHRNNIFEESYRRIMSVKRPDV 502
Query: 748 LKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFK--TTNEGLLYPNPA 805
LK R+ + + E G+D GG+ RE+ L K FNP G F+ T+ L NP
Sbjct: 503 LKARLWIEFES-----EKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPN 557
Query: 806 AQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPE 865
+ + D + ++ F+GR+ G A++ L++ F F +LG + ++ + S+D E
Sbjct: 558 SGLCNEDHLS-YFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQ--ITLNDMESVDSE 614
Query: 866 VYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVAD 925
Y +L ++ E+D EL L F + + G+ V+LK G +I VT+ N+ YI LV
Sbjct: 615 YYNSLKWI--LENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 672
Query: 926 YRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGG 985
+R ++++ AF +G ++ ++ +++FD+ E+++L+ G + + D + + Y G
Sbjct: 673 WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLG-DVDVNDWRQHSIYKNG 731
Query: 986 YSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPA-----FCIHNGGS 1040
Y +HPVI+ FW+ V E++ +LL+FVT SR P+ GF ELY + F I GS
Sbjct: 732 YCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS 791
Query: 1041 DLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFE 1081
E+LP A TC N L LP + LR KLL A+E A GFE
Sbjct: 792 P-EKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 831
>gi|222352092 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 6 [Homo sapiens]
Length = 834
Score = 187 bits (476), Expect = 4e-47
Identities = 128/401 (31%), Positives = 214/401 (53%), Gaps = 27/401 (6%)
Query: 689 LPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPD- 747
+P+ F+++ F++ K + D P + + + RN I+E++Y ++ PD
Sbjct: 450 VPYSREFKQKYDYFRK-----KLKKPADIP--NRFEMKLHRNNIFEESYRRIMSVKRPDV 502
Query: 748 LKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFK--TTNEGLLYPNPA 805
LK R+ + + E G+D GG+ RE+ L K FNP G F+ T+ L NP
Sbjct: 503 LKARLWIEFES-----EKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPN 557
Query: 806 AQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPE 865
+ + D + ++ F+GR+ G A++ L++ F F +LG + ++ + S+D E
Sbjct: 558 SGLCNEDHLS-YFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQ--ITLNDMESVDSE 614
Query: 866 VYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVAD 925
Y +L ++ E+D EL L F + + G+ V+LK G +I VT+ N+ YI LV
Sbjct: 615 YYNSLKWI--LENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 672
Query: 926 YRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGG 985
+R ++++ AF +G ++ ++ +++FD+ E+++L+ G + + D + + Y G
Sbjct: 673 WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLG-DVDVNDWRQHSIYKNG 731
Query: 986 YSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPA-----FCIHNGGS 1040
Y +HPVI+ FW+ V E++ +LL+FVT SR P+ GF ELY + F I GS
Sbjct: 732 YCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS 791
Query: 1041 DLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFE 1081
E+LP A TC N L LP + LR KLL A+E A GFE
Sbjct: 792 P-EKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 831
>gi|222352090 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 5 [Homo sapiens]
Length = 947
Score = 187 bits (476), Expect = 4e-47
Identities = 128/401 (31%), Positives = 214/401 (53%), Gaps = 27/401 (6%)
Query: 689 LPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPD- 747
+P+ F+++ F++ K + D P + + + RN I+E++Y ++ PD
Sbjct: 563 VPYSREFKQKYDYFRK-----KLKKPADIP--NRFEMKLHRNNIFEESYRRIMSVKRPDV 615
Query: 748 LKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFK--TTNEGLLYPNPA 805
LK R+ + + E G+D GG+ RE+ L K FNP G F+ T+ L NP
Sbjct: 616 LKARLWIEFES-----EKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPN 670
Query: 806 AQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPE 865
+ + D + ++ F+GR+ G A++ L++ F F +LG + ++ + S+D E
Sbjct: 671 SGLCNEDHLS-YFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQ--ITLNDMESVDSE 727
Query: 866 VYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVAD 925
Y +L ++ E+D EL L F + + G+ V+LK G +I VT+ N+ YI LV
Sbjct: 728 YYNSLKWI--LENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 785
Query: 926 YRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGG 985
+R ++++ AF +G ++ ++ +++FD+ E+++L+ G + + D + + Y G
Sbjct: 786 WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLG-DVDVNDWRQHSIYKNG 844
Query: 986 YSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPA-----FCIHNGGS 1040
Y +HPVI+ FW+ V E++ +LL+FVT SR P+ GF ELY + F I GS
Sbjct: 845 YCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS 904
Query: 1041 DLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFE 1081
E+LP A TC N L LP + LR KLL A+E A GFE
Sbjct: 905 P-EKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 944
>gi|222352088 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 4 [Homo sapiens]
Length = 967
Score = 187 bits (476), Expect = 4e-47
Identities = 128/401 (31%), Positives = 214/401 (53%), Gaps = 27/401 (6%)
Query: 689 LPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPD- 747
+P+ F+++ F++ K + D P + + + RN I+E++Y ++ PD
Sbjct: 583 VPYSREFKQKYDYFRK-----KLKKPADIP--NRFEMKLHRNNIFEESYRRIMSVKRPDV 635
Query: 748 LKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFK--TTNEGLLYPNPA 805
LK R+ + + E G+D GG+ RE+ L K FNP G F+ T+ L NP
Sbjct: 636 LKARLWIEFES-----EKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPN 690
Query: 806 AQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPE 865
+ + D + ++ F+GR+ G A++ L++ F F +LG + ++ + S+D E
Sbjct: 691 SGLCNEDHLS-YFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQ--ITLNDMESVDSE 747
Query: 866 VYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVAD 925
Y +L ++ E+D EL L F + + G+ V+LK G +I VT+ N+ YI LV
Sbjct: 748 YYNSLKWI--LENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 805
Query: 926 YRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGG 985
+R ++++ AF +G ++ ++ +++FD+ E+++L+ G + + D + + Y G
Sbjct: 806 WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLG-DVDVNDWRQHSIYKNG 864
Query: 986 YSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPA-----FCIHNGGS 1040
Y +HPVI+ FW+ V E++ +LL+FVT SR P+ GF ELY + F I GS
Sbjct: 865 YCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS 924
Query: 1041 DLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFE 1081
E+LP A TC N L LP + LR KLL A+E A GFE
Sbjct: 925 P-EKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 964
>gi|222352086 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 1 [Homo sapiens]
Length = 975
Score = 187 bits (476), Expect = 4e-47
Identities = 128/401 (31%), Positives = 214/401 (53%), Gaps = 27/401 (6%)
Query: 689 LPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPD- 747
+P+ F+++ F++ K + D P + + + RN I+E++Y ++ PD
Sbjct: 591 VPYSREFKQKYDYFRK-----KLKKPADIP--NRFEMKLHRNNIFEESYRRIMSVKRPDV 643
Query: 748 LKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFK--TTNEGLLYPNPA 805
LK R+ + + E G+D GG+ RE+ L K FNP G F+ T+ L NP
Sbjct: 644 LKARLWIEFES-----EKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPN 698
Query: 806 AQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPE 865
+ + D + ++ F+GR+ G A++ L++ F F +LG + ++ + S+D E
Sbjct: 699 SGLCNEDHLS-YFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQ--ITLNDMESVDSE 755
Query: 866 VYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVAD 925
Y +L ++ E+D EL L F + + G+ V+LK G +I VT+ N+ YI LV
Sbjct: 756 YYNSLKWI--LENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 813
Query: 926 YRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGG 985
+R ++++ AF +G ++ ++ +++FD+ E+++L+ G + + D + + Y G
Sbjct: 814 WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLG-DVDVNDWRQHSIYKNG 872
Query: 986 YSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPA-----FCIHNGGS 1040
Y +HPVI+ FW+ V E++ +LL+FVT SR P+ GF ELY + F I GS
Sbjct: 873 YCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS 932
Query: 1041 DLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFE 1081
E+LP A TC N L LP + LR KLL A+E A GFE
Sbjct: 933 P-EKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 972
>gi|222352084 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 187 bits (476), Expect = 4e-47
Identities = 128/401 (31%), Positives = 214/401 (53%), Gaps = 27/401 (6%)
Query: 689 LPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPD- 747
+P+ F+++ F++ K + D P + + + RN I+E++Y ++ PD
Sbjct: 470 VPYSREFKQKYDYFRK-----KLKKPADIP--NRFEMKLHRNNIFEESYRRIMSVKRPDV 522
Query: 748 LKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFK--TTNEGLLYPNPA 805
LK R+ + + E G+D GG+ RE+ L K FNP G F+ T+ L NP
Sbjct: 523 LKARLWIEFES-----EKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPN 577
Query: 806 AQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPE 865
+ + D + ++ F+GR+ G A++ L++ F F +LG + ++ + S+D E
Sbjct: 578 SGLCNEDHLS-YFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQ--ITLNDMESVDSE 634
Query: 866 VYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVAD 925
Y +L ++ E+D EL L F + + G+ V+LK G +I VT+ N+ YI LV
Sbjct: 635 YYNSLKWI--LENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 692
Query: 926 YRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGG 985
+R ++++ AF +G ++ ++ +++FD+ E+++L+ G + + D + + Y G
Sbjct: 693 WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLG-DVDVNDWRQHSIYKNG 751
Query: 986 YSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPA-----FCIHNGGS 1040
Y +HPVI+ FW+ V E++ +LL+FVT SR P+ GF ELY + F I GS
Sbjct: 752 YCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS 811
Query: 1041 DLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFE 1081
E+LP A TC N L LP + LR KLL A+E A GFE
Sbjct: 812 P-EKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 851
>gi|222352082 neural precursor cell expressed, developmentally
down-regulated 4-like isoform 2 [Homo sapiens]
Length = 854
Score = 187 bits (476), Expect = 4e-47
Identities = 128/401 (31%), Positives = 214/401 (53%), Gaps = 27/401 (6%)
Query: 689 LPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPD- 747
+P+ F+++ F++ K + D P + + + RN I+E++Y ++ PD
Sbjct: 470 VPYSREFKQKYDYFRK-----KLKKPADIP--NRFEMKLHRNNIFEESYRRIMSVKRPDV 522
Query: 748 LKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFK--TTNEGLLYPNPA 805
LK R+ + + E G+D GG+ RE+ L K FNP G F+ T+ L NP
Sbjct: 523 LKARLWIEFES-----EKGLDYGGVAREWFFLLSKEMFNPYYGLFEYSATDNYTLQINPN 577
Query: 806 AQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPE 865
+ + D + ++ F+GR+ G A++ L++ F F +LG + ++ + S+D E
Sbjct: 578 SGLCNEDHLS-YFTFIGRVAGLAVFHGKLLDGFFIRPFYKMMLGKQ--ITLNDMESVDSE 634
Query: 866 VYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVAD 925
Y +L ++ E+D EL L F + + G+ V+LK G +I VT+ N+ YI LV
Sbjct: 635 YYNSLKWI--LENDPTELDLMFCIDEENFGQTYQVDLKPNGSEIMVTNENKREYIDLVIQ 692
Query: 926 YRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGG 985
+R ++++ AF +G ++ ++ +++FD+ E+++L+ G + + D + + Y G
Sbjct: 693 WRFVNRVQKQMNAFLEGFTELLPIDLIKIFDENELELLMCGLG-DVDVNDWRQHSIYKNG 751
Query: 986 YSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPA-----FCIHNGGS 1040
Y +HPVI+ FW+ V E++ +LL+FVT SR P+ GF ELY + F I GS
Sbjct: 752 YCPNHPVIQWFWKAVLLMDAEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQLFTIEQWGS 811
Query: 1041 DLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFE 1081
E+LP A TC N L LP + LR KLL A+E A GFE
Sbjct: 812 P-EKLPRAHTCFNRLDLPPYETFEDLREKLLMAVENAQGFE 851
>gi|114520609 neural precursor cell expressed, developmentally
down-regulated 4 isoform 1 [Homo sapiens]
Length = 900
Score = 184 bits (468), Expect = 3e-46
Identities = 127/401 (31%), Positives = 209/401 (52%), Gaps = 27/401 (6%)
Query: 689 LPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPD- 747
+P+ ++ + + F+R K + Q D P + + +RR + ED+Y ++ D
Sbjct: 516 VPYSRDYKRKYEFFRR-----KLKKQNDIP--NKFEMKLRRATVLEDSYRRIMGVKRADF 568
Query: 748 LKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFK--TTNEGLLYPNPA 805
LK R+ + E G+D GG+ RE+ + K FNP G F+ T+ L NP
Sbjct: 569 LKARLWIEFDG-----EKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPN 623
Query: 806 AQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPE 865
+ + D + ++ F+GR+ G A+Y L++ F F +L + +H + S+D E
Sbjct: 624 SGLCNEDHLS-YFKFIGRVAGMAVYHGKLLDGFFIRPFYKMML--HKPITLHDMESVDSE 680
Query: 866 VYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVAD 925
Y +L ++ E+D EL L F + G+ ELK GG +I VT+ N+ YI+LV
Sbjct: 681 YYNSLRWI--LENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQ 738
Query: 926 YRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGG 985
+R +I++ AF++G ++ + +++FD+ E+++L+ G + + D + T Y G
Sbjct: 739 WRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLG-DVDVNDWREHTKYKNG 797
Query: 986 YSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELY-----PAFCIHNGGS 1040
YSA+H VI+ FW+ V E++ +LL+FVT SR P+ GF ELY +F + G+
Sbjct: 798 YSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGT 857
Query: 1041 DLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFE 1081
E+LP A TC N L LP + L KL AIE GF+
Sbjct: 858 P-EKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFD 897
>gi|114520607 neural precursor cell expressed, developmentally
down-regulated 4 isoform 2 [Homo sapiens]
Length = 1247
Score = 184 bits (468), Expect = 3e-46
Identities = 127/401 (31%), Positives = 209/401 (52%), Gaps = 27/401 (6%)
Query: 689 LPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPD- 747
+P+ ++ + + F+R K + Q D P + + +RR + ED+Y ++ D
Sbjct: 863 VPYSRDYKRKYEFFRR-----KLKKQNDIP--NKFEMKLRRATVLEDSYRRIMGVKRADF 915
Query: 748 LKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFK--TTNEGLLYPNPA 805
LK R+ + E G+D GG+ RE+ + K FNP G F+ T+ L NP
Sbjct: 916 LKARLWIEFDG-----EKGLDYGGVAREWFFLISKEMFNPYYGLFEYSATDNYTLQINPN 970
Query: 806 AQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPE 865
+ + D + ++ F+GR+ G A+Y L++ F F +L + +H + S+D E
Sbjct: 971 SGLCNEDHLS-YFKFIGRVAGMAVYHGKLLDGFFIRPFYKMML--HKPITLHDMESVDSE 1027
Query: 866 VYKNLLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVAD 925
Y +L ++ E+D EL L F + G+ ELK GG +I VT+ N+ YI+LV
Sbjct: 1028 YYNSLRWI--LENDPTELDLRFIIDEELFGQTHQHELKNGGSEIVVTNKNKKEYIYLVIQ 1085
Query: 926 YRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGG 985
+R +I++ AF++G ++ + +++FD+ E+++L+ G + + D + T Y G
Sbjct: 1086 WRFVNRIQKQMAAFKEGFFELIPQDLIKIFDENELELLMCGLG-DVDVNDWREHTKYKNG 1144
Query: 986 YSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELY-----PAFCIHNGGS 1040
YSA+H VI+ FW+ V E++ +LL+FVT SR P+ GF ELY +F + G+
Sbjct: 1145 YSANHQVIQWFWKAVLMMDSEKRIRLLQFVTGTSRVPMNGFAELYGSNGPQSFTVEQWGT 1204
Query: 1041 DLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFE 1081
E+LP A TC N L LP + L KL AIE GF+
Sbjct: 1205 P-EKLPRAHTCFNRLDLPPYESFEELWDKLQMAIENTQGFD 1244
>gi|116875852 HECT domain and ankyrin repeat containing, E3 ubiquitin
protein ligase 1 [Homo sapiens]
Length = 909
Score = 183 bits (465), Expect = 7e-46
Identities = 126/400 (31%), Positives = 202/400 (50%), Gaps = 34/400 (8%)
Query: 694 PFEERVKIFQRLIYADKQEVQG-DGPFLDGINVTIRRNYIYEDAYDKLSPENEPDLKKRI 752
PF++R + F +++ + + P + + + R+ I+ + + +S N LK+ I
Sbjct: 523 PFKDRCEWFYEHLHSGQPDSDMVHRPVNENDILLVHRDSIFRSSCEVVSKANCAKLKQGI 582
Query: 753 RVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGD 812
V G+ G G+ RE+ + L NP+ F + +G + P + V
Sbjct: 583 AVRFHGEEGM------GQGVVREWFDILSNEIVNPDYALFTQSADGTTF-QPNSNSYVNP 635
Query: 813 SFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLF 872
++ F G++LG AL LV + F F +LG V+ +AS+DPE KNL +
Sbjct: 636 DHLNYFRFAGQILGLALNHRQLVNIYFTRSFYKHILGIP--VNYQDVASIDPEYAKNLQW 693
Query: 873 LKSYEDDVEELG--LNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLNR 930
+ ++D+ +LG L F+V + G + V LK GG I VT N+ Y+ LV + R+ R
Sbjct: 694 I--LDNDISDLGLELTFSVETDVFGAMEEVPLKPGGGSILVTQNNKAEYVQLVTELRMTR 751
Query: 931 QIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADH 990
I+ AF QG + +++FD+ E+++L+SG I + D T Y+ GY +
Sbjct: 752 AIQPQINAFLQGFHMFIPPSLIQLFDEYELELLLSG-MPEIDVSDWIKNTEYTSGYERED 810
Query: 991 PVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPAFCIHNGGSDLER------ 1044
PVI+ FW VVE T EE+ LL+FVT SR P GF + GGS L+
Sbjct: 811 PVIQWFWEVVEDITQEERVLLLQFVTGSSRVPHGGFANIM-------GGSGLQNFTIAAV 863
Query: 1045 ------LPTASTCMNLLKLPEFYDETLLRSKLLYAIECAA 1078
LPT+STC+N+LKLPE+ + +L+ +LL A+ C +
Sbjct: 864 PYTPNLLPTSSTCINMLKLPEYPSKEILKDRLLVALHCGS 903
>gi|40806211 WW domain containing E3 ubiquitin protein ligase 2
isoform 2 [Homo sapiens]
Length = 431
Score = 178 bits (452), Expect = 2e-44
Identities = 120/367 (32%), Positives = 191/367 (52%), Gaps = 23/367 (6%)
Query: 723 INVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLK 782
+ +++ R ++ED++ ++ DL++R+ + + E G+D GGI RE+ L
Sbjct: 76 VKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRG-----EEGLDYGGIAREWFFLLSH 130
Query: 783 SGFNPNQGFFKTT--NEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFA 840
NP F+ N L NPA+ + ++ F+GR + ALY ++ F
Sbjct: 131 EVLNPMYCLFEYAGKNNYCLQINPASS--INPDHLTYFRFIGRFIAMALYHGKFIDTGFT 188
Query: 841 GFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNND--LGEAQ 898
F ++L + L S+DPE Y +++++K E+++EE GL + + LG+
Sbjct: 189 LPFYKRMLNKRPT--LKDLESIDPEFYNSIVWIK--ENNLEECGLELYFIQDMEILGKVT 244
Query: 899 VVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQ 958
ELK GG+ I VT N+ YI L+ D+R R + + AF G V LEWLR FD++
Sbjct: 245 THELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEK 304
Query: 959 EIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSC 1018
E+++++ G Q I + D + T Y Y+ + I+ FW+VV+ +E++ +LL+FVT
Sbjct: 305 ELELMLCGMQ-EIDMSDWQKSTIYR-HYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGT 362
Query: 1019 SRPPLLGFKELYPA-----FCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYA 1073
R P+ GF EL + FCI G + LP + TC N L LP + LR KLLYA
Sbjct: 363 CRLPVGGFAELIGSNGPQKFCIDKVGKE-TWLPRSHTCFNRLDLPPYKSYEQLREKLLYA 421
Query: 1074 IECAAGF 1080
IE GF
Sbjct: 422 IEETEGF 428
>gi|40806207 WW domain containing E3 ubiquitin protein ligase 2
isoform 1 [Homo sapiens]
Length = 870
Score = 178 bits (452), Expect = 2e-44
Identities = 120/367 (32%), Positives = 191/367 (52%), Gaps = 23/367 (6%)
Query: 723 INVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLK 782
+ +++ R ++ED++ ++ DL++R+ + + E G+D GGI RE+ L
Sbjct: 515 VKISVSRQTLFEDSFQQIMNMKPYDLRRRLYIIMRG-----EEGLDYGGIAREWFFLLSH 569
Query: 783 SGFNPNQGFFKTT--NEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFA 840
NP F+ N L NPA+ + ++ F+GR + ALY ++ F
Sbjct: 570 EVLNPMYCLFEYAGKNNYCLQINPASS--INPDHLTYFRFIGRFIAMALYHGKFIDTGFT 627
Query: 841 GFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLNFTVVNND--LGEAQ 898
F ++L + L S+DPE Y +++++K E+++EE GL + + LG+
Sbjct: 628 LPFYKRMLNKRPT--LKDLESIDPEFYNSIVWIK--ENNLEECGLELYFIQDMEILGKVT 683
Query: 899 VVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQ 958
ELK GG+ I VT N+ YI L+ D+R R + + AF G V LEWLR FD++
Sbjct: 684 THELKEGGESIRVTEENKEEYIMLLTDWRFTRGVEEQTKAFLDGFNEVAPLEWLRYFDEK 743
Query: 959 EIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSC 1018
E+++++ G Q I + D + T Y Y+ + I+ FW+VV+ +E++ +LL+FVT
Sbjct: 744 ELELMLCGMQ-EIDMSDWQKSTIYR-HYTKNSKQIQWFWQVVKEMDNEKRIRLLQFVTGT 801
Query: 1019 SRPPLLGFKELYPA-----FCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYA 1073
R P+ GF EL + FCI G + LP + TC N L LP + LR KLLYA
Sbjct: 802 CRLPVGGFAELIGSNGPQKFCIDKVGKE-TWLPRSHTCFNRLDLPPYKSYEQLREKLLYA 860
Query: 1074 IECAAGF 1080
IE GF
Sbjct: 861 IEETEGF 867
>gi|31317292 Smad ubiquitination regulatory factor 1 isoform 1 [Homo
sapiens]
Length = 757
Score = 176 bits (447), Expect = 8e-44
Identities = 121/382 (31%), Positives = 194/382 (50%), Gaps = 24/382 (6%)
Query: 710 KQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDG 769
+ E+ P + + R I+E++Y ++ DLKKR+ V E G+D
Sbjct: 386 RHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRG-----EEGLDY 440
Query: 770 GGIFREFLNELLKSGFNPNQGFFK--TTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGK 827
GG+ RE+L L NP G F+ T N +L NP + + +++F+GR++G
Sbjct: 441 GGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS--INPDHLSYFHFVGRIMGL 498
Query: 828 ALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEE-LGLN 886
A++ + F F +LLG + + L S+DPE++K+L+++ E+D+ L
Sbjct: 499 AVFHGHYINGGFTVPFYKQLLGKP--IQLSDLESVDPELHKSLVWI--LENDITPVLDHT 554
Query: 887 FTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANV 946
F V +N G ELK G+++PVT N+ Y+ L ++R R I LA ++G +
Sbjct: 555 FCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNEL 614
Query: 947 VSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDE 1006
+ L+ FDQ+E++++I G I L D KS T AD +++ FW+ VE F +E
Sbjct: 615 IPQHLLKPFDQKELELIIGGLD-KIDLNDWKSNTRLK-HCVADSNIVRWFWQAVETFDEE 672
Query: 1007 EKRKLLKFVTSCSRPPLLGFKELYPA--------FCIHNGGSDLERLPTASTCMNLLKLP 1058
+ +LL+FVT +R PL GFK L + F IH ++ + LP A TC N + +P
Sbjct: 673 RRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIP 732
Query: 1059 EFYDETLLRSKLLYAIECAAGF 1080
+ L KLL A+E GF
Sbjct: 733 PYESYEKLYEKLLTAVEETCGF 754
>gi|31317290 Smad ubiquitination regulatory factor 1 isoform 2 [Homo
sapiens]
Length = 731
Score = 176 bits (447), Expect = 8e-44
Identities = 121/382 (31%), Positives = 194/382 (50%), Gaps = 24/382 (6%)
Query: 710 KQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDG 769
+ E+ P + + R I+E++Y ++ DLKKR+ V E G+D
Sbjct: 360 RHELSLQQPQAGHCRIEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRG-----EEGLDY 414
Query: 770 GGIFREFLNELLKSGFNPNQGFFK--TTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGK 827
GG+ RE+L L NP G F+ T N +L NP + + +++F+GR++G
Sbjct: 415 GGVAREWLYLLCHEMLNPYYGLFQYSTDNIYMLQINPDSS--INPDHLSYFHFVGRIMGL 472
Query: 828 ALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEE-LGLN 886
A++ + F F +LLG + + L S+DPE++K+L+++ E+D+ L
Sbjct: 473 AVFHGHYINGGFTVPFYKQLLGKP--IQLSDLESVDPELHKSLVWI--LENDITPVLDHT 528
Query: 887 FTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANV 946
F V +N G ELK G+++PVT N+ Y+ L ++R R I LA ++G +
Sbjct: 529 FCVEHNAFGRILQHELKPNGRNVPVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNEL 588
Query: 947 VSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDE 1006
+ L+ FDQ+E++++I G I L D KS T AD +++ FW+ VE F +E
Sbjct: 589 IPQHLLKPFDQKELELIIGGLD-KIDLNDWKSNTRLK-HCVADSNIVRWFWQAVETFDEE 646
Query: 1007 EKRKLLKFVTSCSRPPLLGFKELYPA--------FCIHNGGSDLERLPTASTCMNLLKLP 1058
+ +LL+FVT +R PL GFK L + F IH ++ + LP A TC N + +P
Sbjct: 647 RRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIP 706
Query: 1059 EFYDETLLRSKLLYAIECAAGF 1080
+ L KLL A+E GF
Sbjct: 707 PYESYEKLYEKLLTAVEETCGF 728
>gi|55741473 HECT, C2 and WW domain containing E3 ubiquitin protein
ligase 2 [Homo sapiens]
Length = 1572
Score = 175 bits (444), Expect = 2e-43
Identities = 134/426 (31%), Positives = 210/426 (49%), Gaps = 22/426 (5%)
Query: 663 QSTLDVGLESPPLSVSEERQLAVLTELPFVVPFEERVKIFQRLIYADKQEVQGDGPFLDG 722
QS + SP S +R A P+ FE +++ F R K E +G G
Sbjct: 1162 QSPRGSPVSSPQNSPGTQRANA-RAPAPYKRDFEAKLRNFYR-----KLETKGYGQGPGK 1215
Query: 723 INVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLK 782
+ + IRR+++ EDA++++ + DL++ + L + E G+D G REF + +
Sbjct: 1216 LKLIIRRDHLLEDAFNQIMGYSRKDLQR----NKLYVTFVGEEGLDYSGPSREFFFLVSR 1271
Query: 783 SGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFAGF 842
FNP G F+ + + D+ + F GR+LG AL L++ F
Sbjct: 1272 ELFNPYYGLFEYSANDTYTVQISPMSAFVDNHHEWFRFSGRILGLALIHQYLLDAFFTRP 1331
Query: 843 FLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEE-LGLNFTVVNNDLGEAQVVE 901
F LL D+ L LD E +++L ++K ++D+ + L L FTV G+ E
Sbjct: 1332 FYKALLRILCDLS--DLEYLDEEFHQSLQWMK--DNDIHDILDLTFTVNEEVFGQITERE 1387
Query: 902 LKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQ 961
LK GG +IPVT N+ YI + +R+ R + Q + +G VV + +FD +E++
Sbjct: 1388 LKPGGANIPVTEKNKKEYIERMVKWRIERGVVQQTESLVRGFYEVVDARLVSVFDARELE 1447
Query: 962 VLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRP 1021
++I+G I L D ++ T Y GGY +H VI+ FW VE F +E++ +LL+FVT S
Sbjct: 1448 LVIAGT-AEIDLSDWRNNTEYRGGYHDNHIVIRWFWAAVERFNNEQRLRLLQFVTGTSSI 1506
Query: 1022 PLLGFKELYPA-----FCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYAIEC 1076
P GF L + FC+ G + LP A TC N L LP + ++L KLL A+E
Sbjct: 1507 PYEGFASLRGSNGPRRFCVEKWGK-ITALPRAHTCFNRLDLPPYPSFSMLYEKLLTAVEE 1565
Query: 1077 AAGFEL 1082
+ F L
Sbjct: 1566 TSTFGL 1571
>gi|13654239 WW domain containing E3 ubiquitin protein ligase 1 [Homo
sapiens]
Length = 922
Score = 170 bits (430), Expect = 8e-42
Identities = 118/367 (32%), Positives = 192/367 (52%), Gaps = 23/367 (6%)
Query: 723 INVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLK 782
+ + + R ++ED++ ++ DL++R+ V E G+D GG+ RE+ L
Sbjct: 567 VKINVSRQTLFEDSFQQIMALKPYDLRRRLYVIFRG-----EEGLDYGGLAREWFFLLSH 621
Query: 783 SGFNPNQGFFKTT--NEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFA 840
NP F+ N L NPA+ + ++ F+GR + AL+ ++ F+
Sbjct: 622 EVLNPMYCLFEYAGKNNYCLQINPAST--INPDHLSYFCFIGRFIAMALFHGKFIDTGFS 679
Query: 841 GFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEELGLN--FTVVNNDLGEAQ 898
F ++L S + I L S+D E Y +L++++ ++++EE GL F+V LG+
Sbjct: 680 LPFYKRML--SKKLTIKDLESIDTEFYNSLIWIR--DNNIEECGLEMYFSVDMEILGKVT 735
Query: 899 VVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQ 958
+LK GG +I VT N+ YI L+ ++R +R +++ AF G VV L+WL+ FD++
Sbjct: 736 SHDLKLGGSNILVTEENKDEYIGLMTEWRFSRGVQEQTKAFLDGFNEVVPLQWLQYFDEK 795
Query: 959 EIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSC 1018
E++V++ G Q + L D + T Y Y+ + I FW+ V+ +E + +LL+FVT
Sbjct: 796 ELEVMLCGMQ-EVDLADWQRNTVYR-HYTRNSKQIIWFWQFVKETDNEVRMRLLQFVTGT 853
Query: 1019 SRPPLLGFKELYPA-----FCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYA 1073
R PL GF EL + FCI G D LP + TC N L LP + L+ KLL+A
Sbjct: 854 CRLPLGGFAELMGSNGPQKFCIEKVGKD-TWLPRSHTCFNRLDLPPYKSYEQLKEKLLFA 912
Query: 1074 IECAAGF 1080
IE GF
Sbjct: 913 IEETEGF 919
>gi|12232397 SMAD specific E3 ubiquitin protein ligase 2 [Homo
sapiens]
Length = 748
Score = 169 bits (429), Expect = 1e-41
Identities = 118/377 (31%), Positives = 186/377 (49%), Gaps = 17/377 (4%)
Query: 710 KQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDG 769
+QE+ P + + R I+E++Y ++ DL KR+ + E G+D
Sbjct: 380 RQELSQQQPQAGHCRIEVSREEIFEESYRQVMKMRPKDLWKRLMIKFRG-----EEGLDY 434
Query: 770 GGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKAL 829
GG+ RE+L L NP G F+ + + + V +++F+GR++G A+
Sbjct: 435 GGVAREWLYLLSHEMLNPYYGLFQYSRDDIYTLQINPDSAVNPEHLSYFHFVGRIMGMAV 494
Query: 830 YENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEE-LGLNFT 888
+ ++ F F +LLG S +D L +DP+++ +L+++ E+D+ L F
Sbjct: 495 FHGHYIDGGFTLPFYKQLLGKSITLDDMEL--VDPDLHNSLVWI--LENDITGVLDHTFC 550
Query: 889 VVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVS 948
V +N GE ELK GK IPV N+ Y+ L ++R R I LA ++G V+
Sbjct: 551 VEHNAYGEIIQHELKPNGKSIPVNEENKKEYVRLYVNWRFLRGIEAQFLALQKGFNEVIP 610
Query: 949 LEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDEEK 1008
L+ FD++E++++I G I + D K T + D ++K FW+ VE F +E +
Sbjct: 611 QHLLKTFDEKELELIICGLG-KIDVNDWKVNTRLK-HCTPDSNIVKWFWKAVEFFDEERR 668
Query: 1009 RKLLKFVTSCSRPPLLGFKELYPA-----FCIHNGGSDLERLPTASTCMNLLKLPEFYDE 1063
+LL+FVT SR PL GFK L A F IH + LP A TC N + +P +
Sbjct: 669 ARLLQFVTGSSRVPLQGFKALQGAAGPRLFTIHQIDACTNNLPKAHTCFNRIDIPPYESY 728
Query: 1064 TLLRSKLLYAIECAAGF 1080
L KLL AIE GF
Sbjct: 729 EKLYEKLLTAIEETCGF 745
>gi|27477109 itchy homolog E3 ubiquitin protein ligase [Homo sapiens]
Length = 862
Score = 167 bits (423), Expect = 5e-41
Identities = 116/367 (31%), Positives = 195/367 (53%), Gaps = 23/367 (6%)
Query: 723 INVTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIFREFLNELLK 782
I +T+ R ++ED++ ++ + DL++R+ V E G+D GG+ RE+ L
Sbjct: 507 IKITVTRKTLFEDSFQQIMSFSPQDLRRRLWVIFPG-----EEGLDYGGVAREWFFLLSH 561
Query: 783 SGFNPNQGFFKTTNEG--LLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENMLVELPFA 840
NP F+ + L NPA+ + +++ F+GR + AL+ ++ F+
Sbjct: 562 EVLNPMYCLFEYAGKDNYCLQINPASY--INPDHLKYFRFIGRFIAMALFHGKFIDTGFS 619
Query: 841 GFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSYEDDVEE--LGLNFTVVNNDLGEAQ 898
F ++L + V + L S+DPE Y +L+++K E+++EE L + F+V LGE +
Sbjct: 620 LPFYKRIL--NKPVGLKDLESIDPEFYNSLIWVK--ENNIEECDLEMYFSVDKEILGEIK 675
Query: 899 VVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEWLRMFDQQ 958
+LK G +I VT N+ YI +VA++RL+R + + AF +G ++ ++L+ FD +
Sbjct: 676 SHDLKPNGGNILVTEENKEEYIRMVAEWRLSRGVEEQTQAFFEGFNEILPQQYLQYFDAK 735
Query: 959 EIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDEEKRKLLKFVTSC 1018
E++VL+ G Q I L D + Y Y+ I FW+ V+ +E++ +LL+FVT
Sbjct: 736 ELEVLLCGMQ-EIDLNDWQRHAIYR-HYARTSKQIMWFWQFVKEIDNEKRMRLLQFVTGT 793
Query: 1019 SRPPLLGFKELYPA-----FCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLLYA 1073
R P+ GF +L + FCI G + LP + TC N L LP + L+ KLL+A
Sbjct: 794 CRLPVGGFADLMGSNGPQKFCIEKVGKE-NWLPRSHTCFNRLDLPPYKSYEQLKEKLLFA 852
Query: 1074 IECAAGF 1080
IE GF
Sbjct: 853 IEETEGF 859
>gi|37620181 hect domain and RLD 4 isoform b [Homo sapiens]
Length = 1049
Score = 167 bits (423), Expect = 5e-41
Identities = 117/371 (31%), Positives = 177/371 (47%), Gaps = 20/371 (5%)
Query: 718 PFLDGIN----VTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIF 773
P ++ +N + +RR I DA + L D KK ++V + E +D GG+
Sbjct: 692 PVIESVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVG-----EDAVDAGGVR 746
Query: 774 REFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENM 833
+EF +++ +P G F+ + L D F + +G + G A+Y
Sbjct: 747 KEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLF----HLIGVICGLAIYNCT 802
Query: 834 LVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSY-EDDVEE-LGLNFTVVN 891
+V+L F KLL +D L L P+V +++ L Y EDD+EE LNFT+
Sbjct: 803 IVDLHFPLALYKKLLKKKPSLD--DLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITV 860
Query: 892 NDLGEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEW 951
+ G +V EL G D V NR ++ DY N+ + AF G V +
Sbjct: 861 ENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKV 920
Query: 952 LRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDEEKRKL 1011
L +F E+Q ++ G ++L+ T Y G Y A+HP IK+FW V E+K++
Sbjct: 921 LLLFQPNELQAMVIG-NTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQF 979
Query: 1012 LKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLL 1071
L F+T R P+LG K L I + G E LP + TC NLL LP++ ++ LRSKL+
Sbjct: 980 LLFLTGSDRIPILGMKSL--KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLI 1037
Query: 1072 YAIECAAGFEL 1082
AI+ GF L
Sbjct: 1038 QAIDHNEGFSL 1048
>gi|63025188 hect domain and RLD 4 isoform a [Homo sapiens]
Length = 1057
Score = 167 bits (423), Expect = 5e-41
Identities = 117/371 (31%), Positives = 177/371 (47%), Gaps = 20/371 (5%)
Query: 718 PFLDGIN----VTIRRNYIYEDAYDKLSPENEPDLKKRIRVHLLNAHGLDEAGIDGGGIF 773
P ++ +N + +RR I DA + L D KK ++V + E +D GG+
Sbjct: 700 PVIESVNPCLILVVRRENIVGDAMEVLRKTKNIDYKKPLKVIFVG-----EDAVDAGGVR 754
Query: 774 REFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQMLVGDSFARHYYFLGRMLGKALYENM 833
+EF +++ +P G F+ + L D F + +G + G A+Y
Sbjct: 755 KEFFLLIMRELLDPKYGMFRYYEDSRLIWFSDKTFEDSDLF----HLIGVICGLAIYNCT 810
Query: 834 LVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKNLLFLKSY-EDDVEE-LGLNFTVVN 891
+V+L F KLL +D L L P+V +++ L Y EDD+EE LNFT+
Sbjct: 811 IVDLHFPLALYKKLLKKKPSLD--DLKELMPDVGRSMQQLLDYPEDDIEETFCLNFTITV 868
Query: 892 NDLGEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLNRQIRQHCLAFRQGLANVVSLEW 951
+ G +V EL G D V NR ++ DY N+ + AF G V +
Sbjct: 869 ENFGATEVKELVLNGADTAVNKQNRQEFVDAYVDYIFNKSVASLFDAFHAGFHKVCGGKV 928
Query: 952 LRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSADHPVIKVFWRVVEGFTDEEKRKL 1011
L +F E+Q ++ G ++L+ T Y G Y A+HP IK+FW V E+K++
Sbjct: 929 LLLFQPNELQAMVIG-NTNYDWKELEKNTEYKGEYWAEHPTIKIFWEVFHELPLEKKKQF 987
Query: 1012 LKFVTSCSRPPLLGFKELYPAFCIHNGGSDLERLPTASTCMNLLKLPEFYDETLLRSKLL 1071
L F+T R P+LG K L I + G E LP + TC NLL LP++ ++ LRSKL+
Sbjct: 988 LLFLTGSDRIPILGMKSL--KLVIQSTGGGEEYLPVSHTCFNLLDLPKYTEKETLRSKLI 1045
Query: 1072 YAIECAAGFEL 1082
AI+ GF L
Sbjct: 1046 QAIDHNEGFSL 1056
>gi|94536811 NEDD4-like ubiquitin-protein ligase 1 [Homo sapiens]
Length = 1606
Score = 164 bits (416), Expect = 3e-40
Identities = 124/398 (31%), Positives = 193/398 (48%), Gaps = 19/398 (4%)
Query: 690 PFVVPFEERVKIFQRLIYADKQEVQGDGPFLDGINVTIRRNYIYEDAYDKLSPENEPDLK 749
P+ FE +++ F R K E +G G I + IRR+++ E ++++ + +L+
Sbjct: 1222 PYRRDFEAKLRNFYR-----KLEAKGFGQGPGKIKLIIRRDHLLEGTFNQVMAYSRKELQ 1276
Query: 750 KRIRVHLLNAHGLDEAGIDGGGIFREFLNELLKSGFNPNQGFFKTTNEGLLYPNPAAQML 809
+ + L + E G+D G REF L + FNP G F+ + +
Sbjct: 1277 R----NKLYVTFVGEEGLDYSGPSREFFFLLSQELFNPYYGLFEYSANDTYTVQISPMSA 1332
Query: 810 VGDSFARHYYFLGRMLGKALYENMLVELPFAGFFLSKLLGTSADVDIHHLASLDPEVYKN 869
++ + F GR+LG AL L++ F F LL D+ L LD E +++
Sbjct: 1333 FVENHLEWFRFSGRILGLALIHQYLLDAFFTRPFYKALLRLPCDLS--DLEYLDEEFHQS 1390
Query: 870 LLFLKSYEDDVEELGLNFTVVNNDLGEAQVVELKFGGKDIPVTSANRIAYIHLVADYRLN 929
L ++K + + L L FTV G+ ELK GG + VT N+ YI + +R+
Sbjct: 1391 LQWMKD-NNITDILDLTFTVNEEVFGQVTERELKSGGANTQVTEKNKKEYIERMVKWRVE 1449
Query: 930 RQIRQHCLAFRQGLANVVSLEWLRMFDQQEIQVLISGAQVPISLEDLKSFTNYSGGYSAD 989
R + Q A +G VV + +FD +E++++I+G I L D ++ T Y GGY
Sbjct: 1450 RGVVQQTEALVRGFYEVVDSRLVSVFDARELELVIAGT-AEIDLNDWRNNTEYRGGYHDG 1508
Query: 990 HPVIKVFWRVVEGFTDEEKRKLLKFVTSCSRPPLLGFKELYPA-----FCIHNGGSDLER 1044
H VI+ FW VE F +E++ +LL+FVT S P GF L + FCI G +
Sbjct: 1509 HLVIRWFWAAVERFNNEQRLRLLQFVTGTSSVPYEGFAALRGSNGLRRFCIEKWGK-ITS 1567
Query: 1045 LPTASTCMNLLKLPEFYDETLLRSKLLYAIECAAGFEL 1082
LP A TC N L LP + ++L KLL A+E + F L
Sbjct: 1568 LPRAHTCFNRLDLPPYPSYSMLYEKLLTAVEETSTFGL 1605
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.322 0.138 0.405
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,215,382
Number of Sequences: 37866
Number of extensions: 1716879
Number of successful extensions: 6870
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 50
Number of HSP's successfully gapped in prelim test: 15
Number of HSP's that attempted gapping in prelim test: 6504
Number of HSP's gapped (non-prelim): 203
length of query: 1083
length of database: 18,247,518
effective HSP length: 113
effective length of query: 970
effective length of database: 13,968,660
effective search space: 13549600200
effective search space used: 13549600200
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.