Guide to the Human Genome
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Search of human proteins with 187960090

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|187960090 SMG5 homolog nonsense mediated mRNA decay factor
[Homo sapiens]
         (1016 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|187960090 SMG5 homolog nonsense mediated mRNA decay factor [H...  2034   0.0  
gi|42475558 SMG-7 homolog isoform 1 [Homo sapiens]                     79   2e-14
gi|42476070 SMG-7 homolog isoform 2 [Homo sapiens]                     79   2e-14
gi|42476066 SMG-7 homolog isoform 4 [Homo sapiens]                     77   6e-14
gi|115511020 Smg-6 homolog, nonsense mediated mRNA decay factor ...    75   2e-13
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    44   6e-04
gi|156104891 general transcription factor IIF, polypeptide 1, 74...    44   6e-04
gi|217330641 IWS1 homolog [Homo sapiens]                               44   8e-04
gi|58761548 tau tubulin kinase 1 [Homo sapiens]                        44   0.001
gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]                    44   0.001
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]              43   0.002
gi|117968621 MACRO domain containing 2 isoform 1 [Homo sapiens]        42   0.003
gi|74325776 MACRO domain containing 2 isoform 2 [Homo sapiens]         42   0.003
gi|150378543 MYST histone acetyltransferase (monocytic leukemia)...    42   0.004
gi|150378463 MYST histone acetyltransferase (monocytic leukemia)...    42   0.004
gi|150378493 MYST histone acetyltransferase (monocytic leukemia)...    42   0.004
gi|168229156 NFKB activating protein [Homo sapiens]                    41   0.005
gi|55741677 SET domain containing 1A [Homo sapiens]                    40   0.009
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1...    40   0.009
gi|4759128 solute carrier family 24 (sodium/potassium/calcium ex...    40   0.015
gi|34482047 adaptor-related protein complex 3, beta 2 subunit [H...    39   0.019
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom...    39   0.019
gi|126723060 zinc finger CCCH-type containing 4 [Homo sapiens]         39   0.019
gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]     39   0.025
gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]     39   0.025
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof...    39   0.025
gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isof...    39   0.025
gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isof...    39   0.025
gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isof...    39   0.025
gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isof...    39   0.025

>gi|187960090 SMG5 homolog nonsense mediated mRNA decay factor [Homo
            sapiens]
          Length = 1016

 Score = 2035 bits (5271), Expect = 0.0
 Identities = 1016/1016 (100%), Positives = 1016/1016 (100%)

Query: 1    MSQGPPTGESSEPEAKVLHTKRLYRAVVEAVHRLDLILCNKTAYQEVFKPENISLRNKLR 60
            MSQGPPTGESSEPEAKVLHTKRLYRAVVEAVHRLDLILCNKTAYQEVFKPENISLRNKLR
Sbjct: 1    MSQGPPTGESSEPEAKVLHTKRLYRAVVEAVHRLDLILCNKTAYQEVFKPENISLRNKLR 60

Query: 61   ELCVKLMFLHPVDYGRKAEELLWRKVYYEVIQLIKTNKKHIHSRSTLECAYRTHLVAGIG 120
            ELCVKLMFLHPVDYGRKAEELLWRKVYYEVIQLIKTNKKHIHSRSTLECAYRTHLVAGIG
Sbjct: 61   ELCVKLMFLHPVDYGRKAEELLWRKVYYEVIQLIKTNKKHIHSRSTLECAYRTHLVAGIG 120

Query: 121  FYQHLLLYIQSHYQLELQCCIDWTHVTDPLIGCKKPVSASGKEMDWAQMACHRCLVYLGD 180
            FYQHLLLYIQSHYQLELQCCIDWTHVTDPLIGCKKPVSASGKEMDWAQMACHRCLVYLGD
Sbjct: 121  FYQHLLLYIQSHYQLELQCCIDWTHVTDPLIGCKKPVSASGKEMDWAQMACHRCLVYLGD 180

Query: 181  LSRYQNELAGVDTELLAERFYYQALSVAPQIGMPFNQLGTLAGSKYYNVEAMYCYLRCIQ 240
            LSRYQNELAGVDTELLAERFYYQALSVAPQIGMPFNQLGTLAGSKYYNVEAMYCYLRCIQ
Sbjct: 181  LSRYQNELAGVDTELLAERFYYQALSVAPQIGMPFNQLGTLAGSKYYNVEAMYCYLRCIQ 240

Query: 241  SEVSFEGAYGNLKRLYDKAAKMYHQLKKCETRKLSPGKKRCKDIKRLLVNFMYLQSLLQP 300
            SEVSFEGAYGNLKRLYDKAAKMYHQLKKCETRKLSPGKKRCKDIKRLLVNFMYLQSLLQP
Sbjct: 241  SEVSFEGAYGNLKRLYDKAAKMYHQLKKCETRKLSPGKKRCKDIKRLLVNFMYLQSLLQP 300

Query: 301  KSSSVDSELTSLCQSVLEDFNLCLFYLPSSPNLSLASEDEEEYESGYAFLPDLLIFQMVI 360
            KSSSVDSELTSLCQSVLEDFNLCLFYLPSSPNLSLASEDEEEYESGYAFLPDLLIFQMVI
Sbjct: 301  KSSSVDSELTSLCQSVLEDFNLCLFYLPSSPNLSLASEDEEEYESGYAFLPDLLIFQMVI 360

Query: 361  ICLMCVHSLERAGSKQYSAAIAFTLALFSHLVNHVNIRLQAELEEGENPVPAFQSDGTDE 420
            ICLMCVHSLERAGSKQYSAAIAFTLALFSHLVNHVNIRLQAELEEGENPVPAFQSDGTDE
Sbjct: 361  ICLMCVHSLERAGSKQYSAAIAFTLALFSHLVNHVNIRLQAELEEGENPVPAFQSDGTDE 420

Query: 421  PESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDLSEGFES 480
            PESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDLSEGFES
Sbjct: 421  PESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDLSEGFES 480

Query: 481  DSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTRSPTLE 540
            DSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTRSPTLE
Sbjct: 481  DSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTRSPTLE 540

Query: 541  PPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSNLLLQPTTNPHT 600
            PPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSNLLLQPTTNPHT
Sbjct: 541  PPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSNLLLQPTTNPHT 600

Query: 601  SASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERSIQEKLQVLMAEGLLPAVKV 660
            SASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERSIQEKLQVLMAEGLLPAVKV
Sbjct: 601  SASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERSIQEKLQVLMAEGLLPAVKV 660

Query: 661  FLDWLRTNPDLIIVCAQSSQSLWNRLSVLLNLLPAAGELQESGLALCPEVQDLLEGCELP 720
            FLDWLRTNPDLIIVCAQSSQSLWNRLSVLLNLLPAAGELQESGLALCPEVQDLLEGCELP
Sbjct: 661  FLDWLRTNPDLIIVCAQSSQSLWNRLSVLLNLLPAAGELQESGLALCPEVQDLLEGCELP 720

Query: 721  DLPSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLLSTLEESVVRICCIRSFGHFIARLQ 780
            DLPSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLLSTLEESVVRICCIRSFGHFIARLQ
Sbjct: 721  DLPSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLLSTLEESVVRICCIRSFGHFIARLQ 780

Query: 781  GSILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAQEEARRNRLMRDMAQLRLQLEVSQL 840
            GSILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAQEEARRNRLMRDMAQLRLQLEVSQL
Sbjct: 781  GSILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAQEEARRNRLMRDMAQLRLQLEVSQL 840

Query: 841  EGSLQQPKAQSAMSPYLVPDTQALCHHLPVIRQLATSGRFIVIIPRTVIDGLDLLKKEHP 900
            EGSLQQPKAQSAMSPYLVPDTQALCHHLPVIRQLATSGRFIVIIPRTVIDGLDLLKKEHP
Sbjct: 841  EGSLQQPKAQSAMSPYLVPDTQALCHHLPVIRQLATSGRFIVIIPRTVIDGLDLLKKEHP 900

Query: 901  GARDGIRYLEAEFKKGNRYIRCQKEVGKSFERHKLKRQDADAWTLYKILDSCKQLTLAQG 960
            GARDGIRYLEAEFKKGNRYIRCQKEVGKSFERHKLKRQDADAWTLYKILDSCKQLTLAQG
Sbjct: 901  GARDGIRYLEAEFKKGNRYIRCQKEVGKSFERHKLKRQDADAWTLYKILDSCKQLTLAQG 960

Query: 961  AGEEDPSGMVTIITGLPLDNPSVLSGPMQAALQAAAHASVDIKNVLDFYKQWKEIG 1016
            AGEEDPSGMVTIITGLPLDNPSVLSGPMQAALQAAAHASVDIKNVLDFYKQWKEIG
Sbjct: 961  AGEEDPSGMVTIITGLPLDNPSVLSGPMQAALQAAAHASVDIKNVLDFYKQWKEIG 1016


>gi|42475558 SMG-7 homolog isoform 1 [Homo sapiens]
          Length = 1137

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 62/225 (27%), Positives = 106/225 (47%), Gaps = 29/225 (12%)

Query: 56  RNKLRELCVKLMFLHPVDYG--RKAEELLWRKVYYEVIQLIKTNKKHIHS--RSTLECAY 111
           R  L++L  K M +  ++Y   +K E+ LW   +   I  ++   K+  +  RS ++   
Sbjct: 33  RQALQDLYQK-MLVTDLEYALDKKVEQDLWNHAFKNQITTLQGQAKNRANPNRSEVQANL 91

Query: 112 RTHLVAGIGFYQHLLLYIQSHYQLELQCCIDWTHV---------TDPLIGCKKPVSASGK 162
              L A  GFY  LL  + + + ++L C +  + +         T  ++   KP S+S  
Sbjct: 92  SLFLEAASGFYTQLLQELCTVFNVDLPCRVKSSQLGIISNKQTHTSAIV---KPQSSS-- 146

Query: 163 EMDWAQMACHRCLVYLGDLSRYQNELAGVDTELLAERFYYQALSVAPQIGMPFNQLGTLA 222
                   C  CLV+LGD++RY+N+ +       AE +Y  A  + P  G P+NQL  LA
Sbjct: 147 ----CSYICQHCLVHLGDIARYRNQTSQ------AESYYRHAAQLVPSNGQPYNQLAILA 196

Query: 223 GSKYYNVEAMYCYLRCIQSEVSFEGAYGNLKRLYDKAAKMYHQLK 267
            SK  ++  ++ Y R I  +  F  A  NL++   KA +   ++K
Sbjct: 197 SSKGDHLTTIFYYCRSIAVKFPFPAASTNLQKALSKALESRDEVK 241



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 44/168 (26%), Positives = 69/168 (41%), Gaps = 24/168 (14%)

Query: 655 LPAVKVFLDWLRTNPDLI-IVCAQSSQSLWNRLSVLLNLLPAAGELQESGLALCPEVQDL 713
           LPAVKV +DWLR  P +         Q +W  L  LLN             +  P  +DL
Sbjct: 361 LPAVKVSMDWLRLRPRVFQEAVVDERQYIWPWLISLLN-------------SFHPHEEDL 407

Query: 714 LEGCELPDLPSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLLSTLEESV---VRICCIR 770
                 P       LPE+  L+    LR + R  +F      ++  +E     +R   + 
Sbjct: 408 SSISATP-------LPEEFELQGFLALRPSFRNLDFSKGHQGITGDKEGQQRRIRQQRLI 460

Query: 771 SFGHFIARLQGSILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAQEE 818
           S G +IA  Q  ++Q   EVG  + I +  +  L   ++A+  +  +E
Sbjct: 461 SIGKWIADNQPRLIQCENEVGKLLFITEIPELILEDPSEAKENLILQE 508


>gi|42476070 SMG-7 homolog isoform 2 [Homo sapiens]
          Length = 1091

 Score = 79.0 bits (193), Expect = 2e-14
 Identities = 62/225 (27%), Positives = 106/225 (47%), Gaps = 29/225 (12%)

Query: 56  RNKLRELCVKLMFLHPVDYG--RKAEELLWRKVYYEVIQLIKTNKKHIHS--RSTLECAY 111
           R  L++L  K M +  ++Y   +K E+ LW   +   I  ++   K+  +  RS ++   
Sbjct: 33  RQALQDLYQK-MLVTDLEYALDKKVEQDLWNHAFKNQITTLQGQAKNRANPNRSEVQANL 91

Query: 112 RTHLVAGIGFYQHLLLYIQSHYQLELQCCIDWTHV---------TDPLIGCKKPVSASGK 162
              L A  GFY  LL  + + + ++L C +  + +         T  ++   KP S+S  
Sbjct: 92  SLFLEAASGFYTQLLQELCTVFNVDLPCRVKSSQLGIISNKQTHTSAIV---KPQSSS-- 146

Query: 163 EMDWAQMACHRCLVYLGDLSRYQNELAGVDTELLAERFYYQALSVAPQIGMPFNQLGTLA 222
                   C  CLV+LGD++RY+N+ +       AE +Y  A  + P  G P+NQL  LA
Sbjct: 147 ----CSYICQHCLVHLGDIARYRNQTSQ------AESYYRHAAQLVPSNGQPYNQLAILA 196

Query: 223 GSKYYNVEAMYCYLRCIQSEVSFEGAYGNLKRLYDKAAKMYHQLK 267
            SK  ++  ++ Y R I  +  F  A  NL++   KA +   ++K
Sbjct: 197 SSKGDHLTTIFYYCRSIAVKFPFPAASTNLQKALSKALESRDEVK 241



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 44/168 (26%), Positives = 69/168 (41%), Gaps = 24/168 (14%)

Query: 655 LPAVKVFLDWLRTNPDLI-IVCAQSSQSLWNRLSVLLNLLPAAGELQESGLALCPEVQDL 713
           LPAVKV +DWLR  P +         Q +W  L  LLN             +  P  +DL
Sbjct: 361 LPAVKVSMDWLRLRPRVFQEAVVDERQYIWPWLISLLN-------------SFHPHEEDL 407

Query: 714 LEGCELPDLPSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLLSTLEESV---VRICCIR 770
                 P       LPE+  L+    LR + R  +F      ++  +E     +R   + 
Sbjct: 408 SSISATP-------LPEEFELQGFLALRPSFRNLDFSKGHQGITGDKEGQQRRIRQQRLI 460

Query: 771 SFGHFIARLQGSILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAQEE 818
           S G +IA  Q  ++Q   EVG  + I +  +  L   ++A+  +  +E
Sbjct: 461 SIGKWIADNQPRLIQCENEVGKLLFITEIPELILEDPSEAKENLILQE 508


>gi|42476066 SMG-7 homolog isoform 4 [Homo sapiens]
          Length = 1049

 Score = 77.4 bits (189), Expect = 6e-14
 Identities = 56/203 (27%), Positives = 95/203 (46%), Gaps = 26/203 (12%)

Query: 76  RKAEELLWRKVYYEVIQLIKTNKKHIHS--RSTLECAYRTHLVAGIGFYQHLLLYIQSHY 133
           +K E+ LW   +   I  ++   K+  +  RS ++      L A  GFY  LL  + + +
Sbjct: 12  KKVEQDLWNHAFKNQITTLQGQAKNRANPNRSEVQANLSLFLEAASGFYTQLLQELCTVF 71

Query: 134 QLELQCCIDWTHV---------TDPLIGCKKPVSASGKEMDWAQMACHRCLVYLGDLSRY 184
            ++L C +  + +         T  ++   KP S+S          C  CLV+LGD++RY
Sbjct: 72  NVDLPCRVKSSQLGIISNKQTHTSAIV---KPQSSS------CSYICQHCLVHLGDIARY 122

Query: 185 QNELAGVDTELLAERFYYQALSVAPQIGMPFNQLGTLAGSKYYNVEAMYCYLRCIQSEVS 244
           +N+ +       AE +Y  A  + P  G P+NQL  LA SK  ++  ++ Y R I  +  
Sbjct: 123 RNQTSQ------AESYYRHAAQLVPSNGQPYNQLAILASSKGDHLTTIFYYCRSIAVKFP 176

Query: 245 FEGAYGNLKRLYDKAAKMYHQLK 267
           F  A  NL++   KA +   ++K
Sbjct: 177 FPAASTNLQKALSKALESRDEVK 199



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 44/168 (26%), Positives = 69/168 (41%), Gaps = 24/168 (14%)

Query: 655 LPAVKVFLDWLRTNPDLI-IVCAQSSQSLWNRLSVLLNLLPAAGELQESGLALCPEVQDL 713
           LPAVKV +DWLR  P +         Q +W  L  LLN             +  P  +DL
Sbjct: 319 LPAVKVSMDWLRLRPRVFQEAVVDERQYIWPWLISLLN-------------SFHPHEEDL 365

Query: 714 LEGCELPDLPSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLLSTLEESV---VRICCIR 770
                 P       LPE+  L+    LR + R  +F      ++  +E     +R   + 
Sbjct: 366 SSISATP-------LPEEFELQGFLALRPSFRNLDFSKGHQGITGDKEGQQRRIRQQRLI 418

Query: 771 SFGHFIARLQGSILQFNPEVGIFVSIAQSEQESLLQQAQAQFRMAQEE 818
           S G +IA  Q  ++Q   EVG  + I +  +  L   ++A+  +  +E
Sbjct: 419 SIGKWIADNQPRLIQCENEVGKLLFITEIPELILEDPSEAKENLILQE 466


>gi|115511020 Smg-6 homolog, nonsense mediated mRNA decay factor
           [Homo sapiens]
          Length = 1419

 Score = 75.5 bits (184), Expect = 2e-13
 Identities = 64/281 (22%), Positives = 132/281 (46%), Gaps = 20/281 (7%)

Query: 9   ESSEPEAKVLHTKRLYRAVVEAVHRLDLILCNKTAYQEVFKPENISLRNKLRELCVKLM- 67
           E  E   + L  + L+R ++      +L L N  +   +  PE +    +LR   ++L  
Sbjct: 567 EEVEQHMRNLQQQELHR-LLRVADNQELQLSNLLSRDRI-SPEGLEKMAQLRAELLQLYE 624

Query: 68  --FLHPVDYG--RKAEELLWRKVYYEVIQLIKTNKK--HIHSRSTLECAYRTHLVAGIGF 121
              L  +++   +  +++LW+  +Y+VI+  +   K  ++ +   +       L  G  F
Sbjct: 625 RCILLDIEFSDNQNVDQILWKNAFYQVIEKFRQLVKDPNVENPEQIRNRLLELLDEGSDF 684

Query: 122 YQHLLLYIQSHYQLELQCCIDWTHVTDPLIGCKKPVSASGKEMDWAQMACHRCLVYLGDL 181
           +  LL  +Q  Y+ +L+  +D   +        KP+    K + +A ++  RC++  GD+
Sbjct: 685 FDSLLQKLQVTYKFKLEDYMDGLAIRS------KPLR---KTVKYALISAQRCMICQGDI 735

Query: 182 SRYQNELAGVDTELLAERFYYQALSVAPQIGMPFNQLGTLAGSKYYNVEAMYCYLRCIQS 241
           +RY+ + +       A  +Y +A  +AP+ G P+NQL  LA      ++A+Y Y+R + +
Sbjct: 736 ARYREQASDTANYGKARSWYLKAQHIAPKNGRPYNQLALLAVYTRRKLDAVYYYMRSLAA 795

Query: 242 EVSFEGAYGNLKRLYDKAAKMYHQLKKCETRK--LSPGKKR 280
                 A  +L  L+++  +   Q++K +  +  LSP + R
Sbjct: 796 SNPILTAKESLMSLFEETKRKAEQMEKKQHEEFDLSPDQWR 836



 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 132/577 (22%), Positives = 228/577 (39%), Gaps = 103/577 (17%)

Query: 422  ESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDLSEGFESD 481
            E+K   E+ E+   E   ++P   + RK +K +        RH   VGDD+   E +   
Sbjct: 812  ETKRKAEQMEKKQHEEFDLSPD--QWRKGKKSTF-------RH---VGDDTTRLEIWIHP 859

Query: 482  SSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTRSPTLEP 541
            S     R+S+G++SG D   E G     + + S++N +   S L     +  TR      
Sbjct: 860  SH---PRSSQGTESGKDSEQENG---LGSLSPSDLNKRFILSFLH-AHGKLFTRIGMETF 912

Query: 542  PRGRSEAPDSLNGPLGPSEASIASN--LQAMSTQMF-----QTKRCFRLAPTFSNLLLQP 594
            P    +        L  S + I S   LQ M+  MF     Q K CF         ++Q 
Sbjct: 913  PAVAEKVLKEFQVLLQHSPSPIGSTRMLQLMTINMFAVHNSQLKDCFSEE---CRSVIQE 969

Query: 595  TTNPHTSASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERSIQEKLQVLMAEGL 654
                   A     V        E A  + S  E  +       ++  I+    V   + L
Sbjct: 970  QAAALGLAMFSLLVRRCTCLLKESAKAQLSSPEDQD-------DQDDIKVSSFVPDLKEL 1022

Query: 655  LPAVKVFLDWLRTNPDL-------IIVCAQSSQSLWNRLSVLLNLLPAAGELQESGLALC 707
            LP+VKV+ DW+   PD        + + +  +  +W+ L+   N+L A   + +S + L 
Sbjct: 1023 LPSVKVWSDWMLGYPDTWNPPPTSLDLPSHVAVDVWSTLADFCNILTA---VNQSEVPLY 1079

Query: 708  PEVQDLLEGCELPDLPSSLLLPEDMALRNLPPLRAAHRRFNFDTDRPLLSTLEESVVRIC 767
             +  D L         + L+L ED  L    PL AA +   +  ++     +     R+ 
Sbjct: 1080 KDPDDDL---------TLLILEEDRLLSGFVPLLAAPQDPCY-VEKTSDKVIAADCKRVT 1129

Query: 768  CIRSFGHFIARLQGSILQFNPEVGIFVSIA------------------QSEQESLL---- 805
             ++ F   +   +  +L F  + G +VS+A                  + E+E ++    
Sbjct: 1130 VLKYFLEALCGQEEPLLAF--KGGKYVSVAPVPDTMGKEMGSQEGTRLEDEEEDVVIEDF 1187

Query: 806  -QQAQAQFRMAQEEARRNR-----LMRDMAQLRLQLEVSQ--LEGSLQQPKAQSAMSP-Y 856
             + ++A+    +++ R  R     L R +A+ + + E  Q  LE   Q  + +  + P +
Sbjct: 1188 EEDSEAEGSGGEDDIRELRAKKLALARKIAEQQRRQEKIQAVLEDHSQMRQMELEIRPLF 1247

Query: 857  LVPDTQALCHHLPVIRQLATSGRFIVIIPRTVIDGLDLLKK----EHPG----------A 902
            LVPDT     HL  + +L  S ++I+++P  VI+ LD L K    +H            A
Sbjct: 1248 LVPDTNGFIDHLASLARLLESRKYILVVPLIVINELDGLAKGQETDHRAGGYARVVQEKA 1307

Query: 903  RDGIRYLEAEFKKGNRYIRCQKEVGKSFERHKLKRQD 939
            R  I +LE  F+  +  +R     G   E    + +D
Sbjct: 1308 RKSIEFLEQRFESRDSCLRALTSRGNELESIAFRSED 1344



 Score = 33.5 bits (75), Expect = 1.0
 Identities = 44/169 (26%), Positives = 66/169 (39%), Gaps = 16/169 (9%)

Query: 400 QAELEEGENPVPAFQSDGTDEPESKEPVEKEE---EPDP---EPPPVTPQVG--EGRKSR 451
           + E EE  N V   +    +E E +  V KEE   +PD    E  P   +VG  +G K +
Sbjct: 162 RVEEEEVLNQVEQLR---VEEDECRGNVAKEEVANKPDRAEIEKSPGGGRVGAAKGEKGK 218

Query: 452 KFSRLSCLRRRRHPPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAE 511
           +  +   +R     P  G          SD   +  R    S +GS+ S EG G   +  
Sbjct: 219 RMGKGEGVRETHDDPARGRPGSAKRYSRSDKRRNRYRTRSTSSAGSNNSAEGAGLTDNGC 278

Query: 512 TDSEMNSQESRSDLEDMEEEEGTRSPTLEPPRGRSEAPDSLNGPLGPSE 560
                +  + R  L    +++ + S T      R + PD L GP   SE
Sbjct: 279 RRRRQDRTKERPRL----KKQVSVSSTDSLDEDRIDEPDGL-GPRRSSE 322


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 38/165 (23%), Positives = 67/165 (40%), Gaps = 8/165 (4%)

Query: 471 DSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEE 530
           DSD S+   SDSS   +  S  S   SD S     +     +DS+ +S +S SD  D + 
Sbjct: 579 DSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDS 638

Query: 531 EEGTRSPTLEPPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSNL 590
           +  +           S++ DS N     S++S +S+    S+    +        +  + 
Sbjct: 639 KSDSSDSNSSDSSDNSDSSDSSNSS-NSSDSSDSSDSSDSSSSSDSSN-------SSDSS 690

Query: 591 LLQPTTNPHTSASHRPCVNGDVDKPSEPASEEGSESEGSESSGRS 635
               ++N   S+      + D    S+ ++   S+S+ S SS  S
Sbjct: 691 DSSDSSNSSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSS 735



 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 49/237 (20%), Positives = 85/237 (35%), Gaps = 13/237 (5%)

Query: 415 SDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDL 474
           SD +D  +S    +  +  D      +    +   S   S  S            D SD 
Sbjct: 753 SDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDS 812

Query: 475 SEGFESDSSH--------DSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLE 526
           S+  +SDSS+        DS+ +S  SDS        G  +  +      NS +S    +
Sbjct: 813 SDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDSSNSSDSSDSSD 872

Query: 527 DMEEEEGTRSPTLEPPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPT 586
                + + S         S++ DS N     S++S +SN  + S+    +      + +
Sbjct: 873 SSNSSDSSDSSDSNESSNSSDSSDSSNS--SDSDSSDSSN-SSDSSDSSNSSDSSESSNS 929

Query: 587 FSNLLLQPTTNPHTSASHRPCVNGDVDKPSEPA--SEEGSESEGSESSGRSCRNERS 641
             N     ++N   S+      N      S  +  S + S+S  S+SS  S  ++ S
Sbjct: 930 SDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSS 986



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 29/139 (20%), Positives = 53/139 (38%)

Query: 415  SDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDL 474
            SD +D  ES +  +  +  D      +    +   S   S  S            D SD 
Sbjct: 1142 SDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDS 1201

Query: 475  SEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGT 534
            S+  +S  S DS+ +S+ SDS           + D+   S+ +   + SD  D  +   +
Sbjct: 1202 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDS 1261

Query: 535  RSPTLEPPRGRSEAPDSLN 553
             S + +    +S++ +  N
Sbjct: 1262 TSDSNDESDSQSKSGNGNN 1280



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 43/188 (22%), Positives = 74/188 (39%), Gaps = 17/188 (9%)

Query: 470 DDSDLSEGFESDSSHDSARASEGSDSG----------------SDKSLEGGGTAFDAETD 513
           D+SD S+   S +S DS+ +S+ SDS                 S  S E   ++  +++D
Sbjct: 652 DNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSD 711

Query: 514 SEMNSQESRSDLEDMEEEEGTRSPTLEPPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQ 573
           S  +S  S S+  D +    + S         S++ DS N     S++S +SN    S  
Sbjct: 712 SSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSS-DSSDSSDSSNSSDSSDS 770

Query: 574 MFQTKRCFRLAPTFSNLLLQPTTNPHTSASHRPCVNGDVDKPSEPASEEGSESEGSESSG 633
              +        + SN     + +  +S S     + D    S+ +  + S S  S +S 
Sbjct: 771 SDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSS 830

Query: 634 RSCRNERS 641
            S  +  S
Sbjct: 831 DSSDSSNS 838



 Score = 41.6 bits (96), Expect = 0.004
 Identities = 48/227 (21%), Positives = 82/227 (36%), Gaps = 10/227 (4%)

Query: 415  SDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDL 474
            SD ++  +S    +  +  D      +    +   S   S  S            D SD 
Sbjct: 1019 SDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDS 1078

Query: 475  SEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGT 534
            S+  ES  S DS+ +S+ SDS           + D+   S+ ++    SD  D    + +
Sbjct: 1079 SDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSD--SSDSS 1136

Query: 535  RSPTLEPPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSNLLLQP 594
             S         SE+ DS       S++S +S+    S     +        + S+     
Sbjct: 1137 DSSNSSDSSDSSESSDS-------SDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS 1189

Query: 595  TTNPHTSASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERS 641
            + +  +S S     + D    S  +S+    S+ S+SS  S  NE S
Sbjct: 1190 SDSSDSSDSSDSSDSSD-SSDSSDSSDSSDSSDSSDSSDSSDSNESS 1235



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 33/120 (27%), Positives = 51/120 (42%), Gaps = 10/120 (8%)

Query: 415  SDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDL 474
            SD +D  +S +  +  +  D      +    +   S   S  S         +  D SD 
Sbjct: 1181 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDS 1240

Query: 475  SEGFESDSSHDSARASEGSDSGSD---------KSLEGGGTAFDAETDSE-MNSQESRSD 524
            S+  +S +S DS+ +S+ SDS SD         KS  G     D+++DSE  +S  S SD
Sbjct: 1241 SDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHSTSD 1300



 Score = 40.8 bits (94), Expect = 0.007
 Identities = 30/152 (19%), Positives = 56/152 (36%)

Query: 415  SDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDL 474
            SD +D  +S +  +  +  D      +    +   S   S  S         +  D SD 
Sbjct: 1097 SDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDS 1156

Query: 475  SEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGT 534
            S+  +S  S DS+ +S+ SDS +         + D+   S+ +     SD  D  +   +
Sbjct: 1157 SDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1216

Query: 535  RSPTLEPPRGRSEAPDSLNGPLGPSEASIASN 566
               +       S   +  +     S++S +SN
Sbjct: 1217 SDSSDSSDSSDSSDSNESSDSSDSSDSSDSSN 1248



 Score = 40.0 bits (92), Expect = 0.011
 Identities = 35/172 (20%), Positives = 67/172 (38%), Gaps = 17/172 (9%)

Query: 470  DDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDME 529
            D SD S   +S +S DS+ +S+ SDS S  S +   ++  +++    +S +S       +
Sbjct: 946  DSSDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSD 1005

Query: 530  EEEGTRSPTLEPPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSN 589
              + + S         S + DS N     S++S +S+    S     +            
Sbjct: 1006 SSDSSDSSDSSNSSDSSNSSDSSNS----SDSSDSSDSSDSSDSSDSSDS---------- 1051

Query: 590  LLLQPTTNPHTSASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERS 641
                 ++N   S+      +      S  +S+    S+ S+SS  S  ++ S
Sbjct: 1052 ---SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSS 1100



 Score = 39.3 bits (90), Expect = 0.019
 Identities = 34/172 (19%), Positives = 66/172 (38%), Gaps = 17/172 (9%)

Query: 470  DDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDME 529
            D S+ S+  +S +S DS+ +S  SD+ +         + D+   S  +   + SD  +  
Sbjct: 907  DSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNSSDSSNSSDSSNSS 966

Query: 530  EEEGTRSPTLEPPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSN 589
            +   + S         S++ DS +     S++S +SN    S     +            
Sbjct: 967  DSSDSNSSDSSDSSNSSDSSDSSDSS-DSSDSSDSSNSSDSSDSSDSS------------ 1013

Query: 590  LLLQPTTNPHTSASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERS 641
                 ++N   S++     N      S  +S+    S+ S+SS  S  ++ S
Sbjct: 1014 ----DSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSS 1061



 Score = 38.1 bits (87), Expect = 0.042
 Identities = 35/151 (23%), Positives = 60/151 (39%), Gaps = 16/151 (10%)

Query: 407 ENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPP 466
           + P  A  ++ TD  +  E +E     +     +TPQ+   R   K + ++        P
Sbjct: 182 DGPQVAGSNNSTDNED--EIIENSCRNEGNTSEITPQINSKRNGTKEAEVT--------P 231

Query: 467 KVGDDSDLSEGFESDSSHDSARASEGSDSGS-DKSLEGGGTAFDAETDSEMNSQESRSDL 525
             G+D+ L     SD S     A E  D GS D   E  G   D+  +S+    +     
Sbjct: 232 GTGEDAGLD---NSDGSPSGNGADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQDHGKE 288

Query: 526 EDMEEEEGTRSPTLE--PPRGRSEAPDSLNG 554
           +D +   G  S + E   P G+ +  + ++G
Sbjct: 289 DDHDSSIGQNSDSKEYYDPEGKEDPHNEVDG 319



 Score = 38.1 bits (87), Expect = 0.042
 Identities = 35/172 (20%), Positives = 64/172 (37%), Gaps = 4/172 (2%)

Query: 470 DDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDME 529
           D SD  +G    S  DS+ +S  SDS      +   +   +++DS   S    SD  D +
Sbjct: 538 DKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDS---SDSDSSDSSDSD 594

Query: 530 EEEGTRSPTLEPPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSN 589
             + + S         S++ DS +     S++S  S   +  +           + +  N
Sbjct: 595 SSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSS-KSESDSSDSDSKSDSSDSNSSDSSDN 653

Query: 590 LLLQPTTNPHTSASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERS 641
                ++N   S+      +      S  +S     S+ S+SS  S  ++ S
Sbjct: 654 SDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSS 705



 Score = 36.6 bits (83), Expect = 0.12
 Identities = 48/239 (20%), Positives = 91/239 (38%), Gaps = 29/239 (12%)

Query: 405 EGENPVPAFQSDGTDEPESKEPVEKEEEPDPE-PPPVTPQVGEGRKSRKFSRLSCLRRRR 463
           +G++P  + +S+G D+  S+         D       +   G G  S             
Sbjct: 461 QGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDS------------- 507

Query: 464 HPPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQES-R 522
              K  +D D     ++++S  +   + G+D  +DKS  G G +  +++DS  +S  S  
Sbjct: 508 ---KGAEDDDSDSTSDTNNSDSNGNGNNGNDD-NDKSDSGKGKSDSSDSDSSDSSNSSDS 563

Query: 523 SDLEDMEEEEGTRSPTLEPPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFR 582
           SD  D +  +   S         S++ DS +     S++S +SN    S     +     
Sbjct: 564 SDSSDSDSSDSNSS-------SDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDS 616

Query: 583 LAPTFSNLLLQPTTNPHTSASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERS 641
              + S      ++   + +S     +   D  S  +S+    S+ S SS  S  ++ S
Sbjct: 617 SDSSDSK---SDSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSS 672



 Score = 36.6 bits (83), Expect = 0.12
 Identities = 26/114 (22%), Positives = 42/114 (36%), Gaps = 1/114 (0%)

Query: 415  SDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDL 474
            SD +D  +S +  +  +  D      +    +   S   S  S            D SD 
Sbjct: 1187 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDS 1246

Query: 475  SEGFES-DSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLED 527
            S   +S DSS  S   S+ +D    +S  G G    +++DS+    +S     D
Sbjct: 1247 SNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSNHSTSD 1300



 Score = 36.2 bits (82), Expect = 0.16
 Identities = 36/171 (21%), Positives = 67/171 (39%), Gaps = 25/171 (14%)

Query: 471 DSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEE 530
           DS+ S+  ++  S DS+ +S  SDS SD S      + D+ + S+ ++    SD  D   
Sbjct: 644 DSNSSDSSDNSDSSDSSNSSNSSDS-SDSS-----DSSDSSSSSDSSNSSDSSDSSDSSN 697

Query: 531 EEGTRSPTLEPPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSNL 590
              +   +       S++ DS N     S++S +S+    S                   
Sbjct: 698 SSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNS----------------- 740

Query: 591 LLQPTTNPHTSASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERS 641
               +++   S++     +      S  +S+    S+ S+SS  S  N+ S
Sbjct: 741 --SDSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSS 789



 Score = 35.8 bits (81), Expect = 0.21
 Identities = 28/123 (22%), Positives = 47/123 (38%), Gaps = 1/123 (0%)

Query: 415  SDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDL 474
            SD +D   S +  +  +  D      +    +   S   S  S            D SD 
Sbjct: 1172 SDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1231

Query: 475  SEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDME-EEEG 533
            +E  +S  S DS+ +S  SDS          +  + E+DS+  S    ++  D + + EG
Sbjct: 1232 NESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEG 1291

Query: 534  TRS 536
            + S
Sbjct: 1292 SDS 1294



 Score = 35.4 bits (80), Expect = 0.27
 Identities = 34/163 (20%), Positives = 70/163 (42%), Gaps = 2/163 (1%)

Query: 479 ESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTRSPT 538
           ++D S      S+ SDS S  S     ++  +++DS  ++  S SD  D +  + + S +
Sbjct: 536 DNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDS 595

Query: 539 LEPPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSNLLLQPTTNP 598
            +     S++ DS +     S++S +S+ ++ S++              S+     +++ 
Sbjct: 596 SDSSNS-SDSSDSSDSS-DSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDSSDN 653

Query: 599 HTSASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERS 641
             S+      N      S  +S+  S S+ S SS  S  ++ S
Sbjct: 654 SDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSS 696



 Score = 31.6 bits (70), Expect = 4.0
 Identities = 27/124 (21%), Positives = 47/124 (37%), Gaps = 4/124 (3%)

Query: 415  SDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDL 474
            SD ++  +S +  +  +  D      +    +   S   S  S            D ++ 
Sbjct: 1175 SDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNES 1234

Query: 475  SEGFESDSSHDSARASEGSDSG-SDKSLEGGGTAFDAETDS---EMNSQESRSDLEDMEE 530
            S+  +S  S DS+ +S+ SDS  S  S        D+++ S     N  +S SD E  + 
Sbjct: 1235 SDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDS 1294

Query: 531  EEGT 534
               T
Sbjct: 1295 NHST 1298


>gi|156104891 general transcription factor IIF, polypeptide 1, 74kDa
           [Homo sapiens]
          Length = 517

 Score = 44.3 bits (103), Expect = 6e-04
 Identities = 50/192 (26%), Positives = 83/192 (43%), Gaps = 19/192 (9%)

Query: 391 LVNHVNIRLQAELEEGENPVPAFQSDGTDEPESKE----PVEKEEEPDPEPPPVTPQVGE 446
           ++NH +I  Q  L++ +      + +     ++ E     +E + E   +    + + G 
Sbjct: 170 VLNHFSIMQQRRLKDQDQDEDEEEKEKRGRRKASELRIHDLEDDLEMSSDASDASGEEG- 228

Query: 447 GR--KSRKFSRLSCLRRRRHPPKVGDDSDLS-------EGFESDSSHDSARASEGSDSGS 497
           GR  K++K + L+   R++   K  DD           EG E D   D + +S+      
Sbjct: 229 GRVPKAKKKAPLAKGGRKKKKKKGSDDEAFEDSDDGDFEGQEVDYMSDGSSSSQEEPESK 288

Query: 498 DKS--LEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTRSPTLEPPRGR---SEAPDSL 552
            K+   E G    D ++DS   S+E +   ED EEEE  ++PT +  + R   SE  DS 
Sbjct: 289 AKAPQQEEGPKGVDEQSDSSEESEEEKPPEEDKEEEEEKKAPTPQEKKRRKDSSEESDSS 348

Query: 553 NGPLGPSEASIA 564
                 SEAS A
Sbjct: 349 EESDIDSEASSA 360


>gi|217330641 IWS1 homolog [Homo sapiens]
          Length = 819

 Score = 43.9 bits (102), Expect = 8e-04
 Identities = 52/241 (21%), Positives = 94/241 (39%), Gaps = 17/241 (7%)

Query: 405 EGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRH 464
           E + P+    SD   E   ++     E  +   PP +    E   ++  S       R+ 
Sbjct: 70  ENDEPLNLNASDSESEELHRQKDSDSESEERAEPPASDSENED-VNQHGSDSESEETRKL 128

Query: 465 PPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSD 524
           P    ++ +L  G  SDS ++       SDS  ++  +    A D+ET+  +  Q S S+
Sbjct: 129 PGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKS--PASDSETEDALKPQISDSE 186

Query: 525 LEDMEEEEGTRSPTLEPPRGR---SEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCF 581
            E+    + + S   EPP+ R   SE+ +     +  SE+      QA  ++  +  +  
Sbjct: 187 SEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPK-- 244

Query: 582 RLAPTFSNLLLQPTTNPHTSASHRPCVNGDVDKP--SEPASEEGSESEGSESSGRSCRNE 639
              P  S+   +       S S     N ++ KP  S+  SE+   ++ S+S        
Sbjct: 245 ---PRISDSESEDPPRHQASDSE----NEELPKPRISDSESEDPPRNQASDSENEELPKP 297

Query: 640 R 640
           R
Sbjct: 298 R 298



 Score = 38.5 bits (88), Expect = 0.032
 Identities = 45/196 (22%), Positives = 79/196 (40%), Gaps = 21/196 (10%)

Query: 401 AELEEGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEG--RKSRKFSRLSC 458
           ++ E  E P P      +++P   +  + E E  P+ P V+    EG  +     S    
Sbjct: 261 SDSENEELPKPRISDSESEDPPRNQASDSENEELPK-PRVSDSESEGPQKGPASDSETED 319

Query: 459 LRRRRHPPKVGDDSD----------LSEGFESDSSHDSAR-ASEGSDSGSDKSLEGGGTA 507
             R +  P+  DDSD           ++ F SDS  D  +  S  S+    K  +     
Sbjct: 320 ASRHKQKPESDDDSDRENKGEDTEMQNDSFHSDSHMDRKKFHSSDSEEEEHKKQKMDSDE 379

Query: 508 FDAETDSEMNSQESRSDLEDMEEEEGTRSPTLEPPRGRSEAPDS----LNGPLGPSEASI 563
            + E + E  ++   + L D E+EE     + +  R  S+A DS    ++   G  E +I
Sbjct: 380 DEKEGEEEKVAKRKAAVLSDSEDEE---KASAKKSRVVSDADDSDSDAVSDKSGKREKTI 436

Query: 564 ASNLQAMSTQMFQTKR 579
           AS+ +  + +    K+
Sbjct: 437 ASDSEEEAGKELSDKK 452



 Score = 35.4 bits (80), Expect = 0.27
 Identities = 37/172 (21%), Positives = 67/172 (38%), Gaps = 17/172 (9%)

Query: 398 RLQAELEEGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVT---------PQVGEGR 448
           +L     E E  +    SD  +E   K P    E  + +  P +         PQ+ +  
Sbjct: 127 KLPGSDSENEELLNGHASDSENEDVGKHPASDSEIEELQKSPASDSETEDALKPQISDSE 186

Query: 449 KSRKFSRLSCLRRRRHPPKV----GDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGG 504
                   +       PPK      +  +L +   SDS  +     + SDS +++  +  
Sbjct: 187 SEEPPRHQASDSENEEPPKPRMSDSESEELPKPQVSDSESEEPPRHQASDSENEELPK-- 244

Query: 505 GTAFDAETDSEMNSQESRSDLEDMEEEEGTRSPTLEPPRGRSEAPDSLNGPL 556
               D+E++     Q S S+ E++ +   + S + +PP  R++A DS N  L
Sbjct: 245 PRISDSESEDPPRHQASDSENEELPKPRISDSESEDPP--RNQASDSENEEL 294



 Score = 32.7 bits (73), Expect = 1.8
 Identities = 37/188 (19%), Positives = 66/188 (35%), Gaps = 43/188 (22%)

Query: 471 DSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEE 530
           + D++E      +    R SE   S  +  L  G    D+E D  +N   S S+ E++  
Sbjct: 30  EDDVNEQHSGSDTGSVERHSENETSDREDGLPKGHHVTDSENDEPLNLNASDSESEELHR 89

Query: 531 EEGTRSPT---LEPPRGRSEAPDS-------------------------LNGPLGPSEAS 562
           ++ + S +    EPP   SE  D                          LNG    SE  
Sbjct: 90  QKDSDSESEERAEPPASDSENEDVNQHGSDSESEETRKLPGSDSENEELLNGHASDSENE 149

Query: 563 IASNLQAMSTQMFQTKRCFRLAPTFSNLLLQPTTNPHTSASHRPCVNGDVDKPSEPASEE 622
                 A  +++ + ++              P ++  T  + +P ++    +  EP   +
Sbjct: 150 DVGKHPASDSEIEELQK-------------SPASDSETEDALKPQISD--SESEEPPRHQ 194

Query: 623 GSESEGSE 630
            S+SE  E
Sbjct: 195 ASDSENEE 202


>gi|58761548 tau tubulin kinase 1 [Homo sapiens]
          Length = 1321

 Score = 43.5 bits (101), Expect = 0.001
 Identities = 33/136 (24%), Positives = 59/136 (43%), Gaps = 15/136 (11%)

Query: 414 QSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSD 473
           Q++G +E E +E  E+EEE D E      +  E  +  +                 +++ 
Sbjct: 728 QANGKEEEEEEEEDEEEEEEDEEEEEEEEEEEEEEEEEEEEE--------------EEAA 773

Query: 474 LSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEG 533
            +          S  +SEGS+  +D+S EG  +   A+   E   + S +D  D+E EEG
Sbjct: 774 AAVALGEVLGPRSGSSSEGSERSTDRSQEGAPSTLLADDQKESRGRASMAD-GDLEPEEG 832

Query: 534 TRSPTLEPPRGRSEAP 549
           +++  L  P    ++P
Sbjct: 833 SKTLVLVSPGDMKKSP 848


>gi|7656879 ALL1 fused gene from 5q31 [Homo sapiens]
          Length = 1163

 Score = 43.5 bits (101), Expect = 0.001
 Identities = 46/169 (27%), Positives = 74/169 (43%), Gaps = 11/169 (6%)

Query: 477 GFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTRS 536
           G  S+ SH +   SEG+D+  D S    G+   + +DSE  S+ S SD E  E  + + S
Sbjct: 408 GSNSEPSHHN---SEGADNSRDDSSSHSGSESSSGSDSE--SESSSSDSEANEPSQ-SAS 461

Query: 537 PTLEPPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSNLLLQPTT 596
           P  EPP       D+    + P + S AS++ +        K+  R   T ++     T+
Sbjct: 462 PEPEPPPTNKWQLDNWLNKVNPHKVSPASSVDSNIPSSQGYKKEGREQGTGNS--YTDTS 519

Query: 597 NPHTSASHRPCVNGDVDKPSEPASEEGSESEGSESSGRSCRNERSIQEK 645
            P  ++S  P   G   K  +  SE G   + S +   S    R++ +K
Sbjct: 520 GPKETSSATP---GRDSKTIQKGSESGRGRQKSPAQSDSTTQRRTVGKK 565



 Score = 32.0 bits (71), Expect = 3.0
 Identities = 30/132 (22%), Positives = 52/132 (39%), Gaps = 8/132 (6%)

Query: 476 EGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTR 535
           E + +  S    +   GS+    +S   G      +  S +NS  SRS   D   +E  R
Sbjct: 154 ESYNNSGSSSRKKGQHGSEHSKSRSSSPG----KPQAVSSLNSSHSRSHGNDHHSKEHQR 209

Query: 536 SPTLEPPRGRSEAPDSLNGPLGP-SEASIASNLQAMSTQMFQTKRCFRLAPTFSNLLLQP 594
           S +   P    ++P  +    G  S  S   +L + S  M Q    + + P      ++P
Sbjct: 210 SKSPRDPDANWDSPSRVPFSSGQHSTQSFPPSLMSKSNSMLQKPTAY-VRPMDGQESMEP 268

Query: 595 --TTNPHTSASH 604
             ++  ++S SH
Sbjct: 269 KLSSEHYSSQSH 280



 Score = 31.6 bits (70), Expect = 4.0
 Identities = 43/218 (19%), Positives = 78/218 (35%), Gaps = 25/218 (11%)

Query: 418 TDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDLSEG 477
           + + E+ EP  +   P+PEPPP               +L     + +P KV   S +   
Sbjct: 448 SSDSEANEP-SQSASPEPEPPPTNKW-----------QLDNWLNKVNPHKVSPASSVDSN 495

Query: 478 FESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTRSP 537
             S   +      EG + G+  S     T+   ET S    ++S++  +  E   G +  
Sbjct: 496 IPSSQGY----KKEGREQGTGNSYT--DTSGPKETSSATPGRDSKTIQKGSESGRGRQK- 548

Query: 538 TLEPPRGRSEAPDSLNGPLGPSEASIASNLQAMSTQMFQTKRCFRLAPTFSNLLLQPTTN 597
              P +  S       G   P +A  A+  +       +++    LA +  +        
Sbjct: 549 --SPAQSDSTTQRRTVGKKQPKKAEKAAAEEPRGGLKIESETPVDLASSMPS----SRHK 602

Query: 598 PHTSASHRPCVNGDVDKPSEPASEEGSESEGSESSGRS 635
             T  S +P +  +      P +E+      S+SS +S
Sbjct: 603 AATKGSRKPNIKKESKSSPRPTAEKKKYKSTSKSSQKS 640



 Score = 30.8 bits (68), Expect = 6.8
 Identities = 27/88 (30%), Positives = 38/88 (43%), Gaps = 11/88 (12%)

Query: 466 PKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDL 525
           P        S G +S   H S R S GS SG++ S    G   D E+    N+  S S  
Sbjct: 115 PSTSQSQKRSSGLQS--GHSSQRTSAGSSSGTNSS----GQRHDRES---YNNSGSSSRK 165

Query: 526 EDMEEEEGTRSPTLEPPRGRSEAPDSLN 553
           +     E ++S +  P  G+ +A  SLN
Sbjct: 166 KGQHGSEHSKSRSSSP--GKPQAVSSLN 191


>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
          Length = 2400

 Score = 42.7 bits (99), Expect = 0.002
 Identities = 33/153 (21%), Positives = 65/153 (42%), Gaps = 5/153 (3%)

Query: 400  QAELEEGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCL 459
            + E +     V A +++G  +PES++    E E + +P     +  E  K  +    S  
Sbjct: 1864 EGEAQPESEDVEAPEAEGEAQPESEDVETPEAEWEVQPESEGAEAPEAEKEAQPETESVE 1923

Query: 460  RRRRHPPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSE-MNS 518
                     G+D   SEG E+  + ++A+ +EG      + +E      +A+ +SE + +
Sbjct: 1924 ALETE----GEDEPESEGAEAQEAEEAAQEAEGQTQPESEVIESQEAEEEAQPESEDVEA 1979

Query: 519  QESRSDLEDMEEEEGTRSPTLEPPRGRSEAPDS 551
             E   + ++ E E    S  +E P    E  ++
Sbjct: 1980 LEVEVETQEAEGEAQPESEDVEAPEAEGEMQEA 2012



 Score = 37.4 bits (85), Expect = 0.072
 Identities = 39/165 (23%), Positives = 69/165 (41%), Gaps = 12/165 (7%)

Query: 397  IRLQAELEEGENPVPAFQSDGTDEPESK-EPVEKEEEPDPEPPPVTPQV-GEGRKSRKFS 454
            + ++ E +E E      +S+  + PE++ E  E EEE  PE   V  Q   EG ++++  
Sbjct: 1980 LEVEVETQEAEGEAQP-ESEDVEAPEAEGEMQEAEEEAQPESDGVEAQPKSEGEEAQEVE 2038

Query: 455  RLSCLRRRRHPPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDS 514
              +           GD    S+G E+  + + A+ +EG    ++          DA+ ++
Sbjct: 2039 GET-------QKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQ-EA 2090

Query: 515  EMNSQESRSDLEDMEEE-EGTRSPTLEPPRGRSEAPDSLNGPLGP 558
            E  +Q     +E  E E E  ++  +E P    EA     G   P
Sbjct: 2091 EGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAP 2135



 Score = 33.1 bits (74), Expect = 1.4
 Identities = 39/169 (23%), Positives = 62/169 (36%), Gaps = 17/169 (10%)

Query: 400  QAELEEGENPVPAFQSDGTDEPESK--EPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLS 457
            +A+  EG   + A +++G  +PES+  E  E E E  PE   V  Q  EG    +   + 
Sbjct: 2109 EAQKAEG---IEAPETEGEAQPESEGIEAPEAEGEAQPESEGVEAQDAEGEAQPESEGIE 2165

Query: 458  C----------LRRRRHPPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTA 507
                       L     P   G+    SEG E+  +   A+         +   E     
Sbjct: 2166 AQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEP 2225

Query: 508  FDAETDSEMNSQESRSDLEDMEEEEGTRSPTLEPPRGRSEAPDSLNGPL 556
               ET       +  S+ E   E++G  SP +    G+SE     + P+
Sbjct: 2226 EGVETPEAEGEAQPESEGETQGEKKG--SPQVSLGDGQSEEASESSSPV 2272



 Score = 32.0 bits (71), Expect = 3.0
 Identities = 49/201 (24%), Positives = 68/201 (33%), Gaps = 41/201 (20%)

Query: 400  QAELEEGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPV------------------- 440
            +A+ E      P  + +   E E  E  E EEE  PEP  V                   
Sbjct: 2188 EAQPESEGIEAPEAEGEAQPELEGVEAPEAEEEAQPEPEGVETPEAEGEAQPESEGETQG 2247

Query: 441  ----TPQV--GEGRKSRKFSRLSCLRRRR--HPPKVGDDSDLSEGFESDSSHDSARASEG 492
                +PQV  G+G+        S +   R   PP  G D+             S  +S G
Sbjct: 2248 EKKGSPQVSLGDGQSEEASESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWG 2307

Query: 493  S----DSGSDKSL--------EGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTRSPTLE 540
            +    DS +D  L        +  GT       + M  + S S+ E  E   G+R+P   
Sbjct: 2308 NCWQKDSENDHVLGDTRSPDAKSTGTPHAERKATRMYPESSTSEQE--EAPLGSRTPEQG 2365

Query: 541  PPRGRSEAPDSLNGPLGPSEA 561
               G     D   G L P+EA
Sbjct: 2366 ASEGYDLQEDQALGSLAPTEA 2386



 Score = 31.2 bits (69), Expect = 5.2
 Identities = 19/76 (25%), Positives = 34/76 (44%), Gaps = 1/76 (1%)

Query: 465  PPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSD 524
            P   G+    SEG E+  +   A+ +EG      + +E      +A+ +SE + +   ++
Sbjct: 1838 PEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESE-DVETPEAE 1896

Query: 525  LEDMEEEEGTRSPTLE 540
             E   E EG  +P  E
Sbjct: 1897 WEVQPESEGAEAPEAE 1912


>gi|117968621 MACRO domain containing 2 isoform 1 [Homo sapiens]
          Length = 425

 Score = 42.0 bits (97), Expect = 0.003
 Identities = 44/169 (26%), Positives = 69/169 (40%), Gaps = 21/169 (12%)

Query: 405 EGENPVPAFQSDGTDEPESKEPVEKEEEPDPE---------PPPVTPQVGEGRKSRKFSR 455
           E E  V   +    + PE K+ VE+ EE   +         P P + +  E  K   F++
Sbjct: 247 EEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAK 306

Query: 456 LSCLRRRRHPPKVGD----DSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAE 511
              + +     +V D    D D  +G E+DS+ +  +    S S   ++ E      DA 
Sbjct: 307 DENITKGG---EVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAV 363

Query: 512 TDSEMNSQESRSDLEDMEEEEGTRSPTLEPPR--GRSEAPDSLNGPLGP 558
               +   E     ED EE+EG ++P  + PR  G+SE    L    GP
Sbjct: 364 I---VEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGP 409


>gi|74325776 MACRO domain containing 2 isoform 2 [Homo sapiens]
          Length = 213

 Score = 42.0 bits (97), Expect = 0.003
 Identities = 44/169 (26%), Positives = 69/169 (40%), Gaps = 21/169 (12%)

Query: 405 EGENPVPAFQSDGTDEPESKEPVEKEEEPDPE---------PPPVTPQVGEGRKSRKFSR 455
           E E  V   +    + PE K+ VE+ EE   +         P P + +  E  K   F++
Sbjct: 12  EEEEDVEMKEDSDENGPEEKQSVEEMEEQSQDADGVNTVTVPGPASEEAVEDCKDEDFAK 71

Query: 456 LSCLRRRRHPPKVGD----DSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAE 511
              + +     +V D    D D  +G E+DS+ +  +    S S   ++ E      DA 
Sbjct: 72  DENITKGG---EVTDHSVRDQDHPDGQENDSTKNEIKIETESQSSYMETEELSSNQEDAV 128

Query: 512 TDSEMNSQESRSDLEDMEEEEGTRSPTLEPPR--GRSEAPDSLNGPLGP 558
               +   E     ED EE+EG ++P  + PR  G+SE    L    GP
Sbjct: 129 I---VEQPEVIPLTEDQEEKEGEKAPGEDTPRMPGKSEGSSDLENTPGP 174


>gi|150378543 MYST histone acetyltransferase (monocytic leukemia) 3
            [Homo sapiens]
          Length = 2004

 Score = 41.6 bits (96), Expect = 0.004
 Identities = 46/188 (24%), Positives = 73/188 (38%), Gaps = 25/188 (13%)

Query: 399  LQAELEEGENPVPAFQSDGTDE-----PESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKF 453
            L+  L EG   +P   S+G         ES E  E+ E P    PP+  +    RK    
Sbjct: 958  LKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFL 1017

Query: 454  SRLSCLRRRRH------PPKVGDDSD-LSEGFE-SDSSHDSARASEGSDSGSDKSLEGGG 505
             R   +R+R+H         + + ++ L E FE SDS     R     +   ++  E   
Sbjct: 1018 HRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDEN 1077

Query: 506  TAFDAETDSEMNSQE-----------SRSDLEDMEEEEGTRSPTLEPPRGRSEAPDSLNG 554
              F  E    ++SQ+           S+ + ED E ++   +P L+P        D  N 
Sbjct: 1078 ELFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPV-SLLRKRDVKNS 1136

Query: 555  PLGPSEAS 562
            PL P  ++
Sbjct: 1137 PLEPDTST 1144



 Score = 38.5 bits (88), Expect = 0.032
 Identities = 41/154 (26%), Positives = 65/154 (42%), Gaps = 32/154 (20%)

Query: 399  LQAELEEGE---------NPVPAFQ---SDGTDEPESKEPVEKEEEPDPEPPPVTPQVGE 446
            +QAE EE E         + VPA     S  + E E+KEP  +EEE   E P V+ +  +
Sbjct: 1229 MQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEE---EKPRVSEEQRQ 1285

Query: 447  GRKSRKFSRLSCLRRRRHPPKVGDDSDLSEGFESDSSHDSARASEGS-DSGSDKSLEGGG 505
              +          ++    P+  ++ D +     +  HD+    +G  +S   K LE   
Sbjct: 1286 SEEE---------QQELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQP 1336

Query: 506  TAFDA-------ETDSEMNSQESRSDLEDMEEEE 532
            T  D        E+  + N Q+SR  ++D EE E
Sbjct: 1337 TREDVKEEPGVQESFLDANMQKSREKIKDKEETE 1370


>gi|150378463 MYST histone acetyltransferase (monocytic leukemia) 3
            [Homo sapiens]
          Length = 2004

 Score = 41.6 bits (96), Expect = 0.004
 Identities = 46/188 (24%), Positives = 73/188 (38%), Gaps = 25/188 (13%)

Query: 399  LQAELEEGENPVPAFQSDGTDE-----PESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKF 453
            L+  L EG   +P   S+G         ES E  E+ E P    PP+  +    RK    
Sbjct: 958  LKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFL 1017

Query: 454  SRLSCLRRRRH------PPKVGDDSD-LSEGFE-SDSSHDSARASEGSDSGSDKSLEGGG 505
             R   +R+R+H         + + ++ L E FE SDS     R     +   ++  E   
Sbjct: 1018 HRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDEN 1077

Query: 506  TAFDAETDSEMNSQE-----------SRSDLEDMEEEEGTRSPTLEPPRGRSEAPDSLNG 554
              F  E    ++SQ+           S+ + ED E ++   +P L+P        D  N 
Sbjct: 1078 ELFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPV-SLLRKRDVKNS 1136

Query: 555  PLGPSEAS 562
            PL P  ++
Sbjct: 1137 PLEPDTST 1144



 Score = 38.5 bits (88), Expect = 0.032
 Identities = 41/154 (26%), Positives = 65/154 (42%), Gaps = 32/154 (20%)

Query: 399  LQAELEEGE---------NPVPAFQ---SDGTDEPESKEPVEKEEEPDPEPPPVTPQVGE 446
            +QAE EE E         + VPA     S  + E E+KEP  +EEE   E P V+ +  +
Sbjct: 1229 MQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEE---EKPRVSEEQRQ 1285

Query: 447  GRKSRKFSRLSCLRRRRHPPKVGDDSDLSEGFESDSSHDSARASEGS-DSGSDKSLEGGG 505
              +          ++    P+  ++ D +     +  HD+    +G  +S   K LE   
Sbjct: 1286 SEEE---------QQELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQP 1336

Query: 506  TAFDA-------ETDSEMNSQESRSDLEDMEEEE 532
            T  D        E+  + N Q+SR  ++D EE E
Sbjct: 1337 TREDVKEEPGVQESFLDANMQKSREKIKDKEETE 1370


>gi|150378493 MYST histone acetyltransferase (monocytic leukemia) 3
            [Homo sapiens]
          Length = 2004

 Score = 41.6 bits (96), Expect = 0.004
 Identities = 46/188 (24%), Positives = 73/188 (38%), Gaps = 25/188 (13%)

Query: 399  LQAELEEGENPVPAFQSDGTDE-----PESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKF 453
            L+  L EG   +P   S+G         ES E  E+ E P    PP+  +    RK    
Sbjct: 958  LKCRLTEGSERLPRRYSEGDRAVLRGFSESSEEEEEPESPRSSSPPILTKPTLKRKKPFL 1017

Query: 454  SRLSCLRRRRH------PPKVGDDSD-LSEGFE-SDSSHDSARASEGSDSGSDKSLEGGG 505
             R   +R+R+H         + + ++ L E FE SDS     R     +   ++  E   
Sbjct: 1018 HRRRRVRKRKHHNSSVVTETISETTEVLDEPFEDSDSERPMPRLEPTFEIDEEEEEEDEN 1077

Query: 506  TAFDAETDSEMNSQE-----------SRSDLEDMEEEEGTRSPTLEPPRGRSEAPDSLNG 554
              F  E    ++SQ+           S+ + ED E ++   +P L+P        D  N 
Sbjct: 1078 ELFPREYFRRLSSQDVLRCQSSSKRKSKDEEEDEESDDADDTPILKPV-SLLRKRDVKNS 1136

Query: 555  PLGPSEAS 562
            PL P  ++
Sbjct: 1137 PLEPDTST 1144



 Score = 38.5 bits (88), Expect = 0.032
 Identities = 41/154 (26%), Positives = 65/154 (42%), Gaps = 32/154 (20%)

Query: 399  LQAELEEGE---------NPVPAFQ---SDGTDEPESKEPVEKEEEPDPEPPPVTPQVGE 446
            +QAE EE E         + VPA     S  + E E+KEP  +EEE   E P V+ +  +
Sbjct: 1229 MQAEAEEAEEGEEEDAASSEVPAASPADSSNSPETETKEPEVEEEE---EKPRVSEEQRQ 1285

Query: 447  GRKSRKFSRLSCLRRRRHPPKVGDDSDLSEGFESDSSHDSARASEGS-DSGSDKSLEGGG 505
              +          ++    P+  ++ D +     +  HD+    +G  +S   K LE   
Sbjct: 1286 SEEE---------QQELEEPEPEEEEDAAAETAQNDDHDADDEDDGHLESTKKKELEEQP 1336

Query: 506  TAFDA-------ETDSEMNSQESRSDLEDMEEEE 532
            T  D        E+  + N Q+SR  ++D EE E
Sbjct: 1337 TREDVKEEPGVQESFLDANMQKSREKIKDKEETE 1370


>gi|168229156 NFKB activating protein [Homo sapiens]
          Length = 415

 Score = 41.2 bits (95), Expect = 0.005
 Identities = 39/149 (26%), Positives = 60/149 (40%), Gaps = 16/149 (10%)

Query: 420 EPESKE--PVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRR-----RHPPKVGDDS 472
           EP+S E  PVE EE         T +  + +KS +    S  RR+     R   K  +DS
Sbjct: 154 EPDSDEHTPVEDEEPKKSTTSASTSEEEKKKKSSRSKERSKKRRKKKSSKRKHKKYSEDS 213

Query: 473 DLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEE 532
           D     E+DSS +  +         +K  +     +  +   +   + S S  ++ +EE 
Sbjct: 214 DSDSDSETDSSDEDNKRRAKKAKKKEKKKKHRSKKYKKKRSKKSRKESSDSSSKESQEE- 272

Query: 533 GTRSPTLEPP---RGRSEAPDSLNGPLGP 558
                 LE P   R ++E P  L GP  P
Sbjct: 273 -----FLENPWKDRTKAEEPSDLIGPEAP 296


>gi|55741677 SET domain containing 1A [Homo sapiens]
          Length = 1707

 Score = 40.4 bits (93), Expect = 0.009
 Identities = 39/145 (26%), Positives = 56/145 (38%), Gaps = 26/145 (17%)

Query: 399  LQAELEEGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSC 458
            L +E EE      + + D  D+ E +E  ++EE  D          GE  +S   S+ S 
Sbjct: 961  LDSEGEEASQESSS-EKDEEDDEEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSL 1019

Query: 459  LRRRRHPPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNS 518
                                +SD  +DS   SE S S S  S      +  + + S  +S
Sbjct: 1020 YA------------------DSDGENDSTSDSESSSSSSSSS------SSSSSSSSSSSS 1055

Query: 519  QESRSDLEDMEEEEGTRS-PTLEPP 542
              S S  ED EEEE   + P+  PP
Sbjct: 1056 SSSESSSEDEEEEERPAALPSASPP 1080



 Score = 35.0 bits (79), Expect = 0.36
 Identities = 27/81 (33%), Positives = 35/81 (43%), Gaps = 1/81 (1%)

Query: 386  ALFSHLVNHVNIRLQAELEEGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVG 445
            ALFS   + V    +  + E E P P       +E E +   E EEE +      +   G
Sbjct: 1326 ALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESSDSSSSSDG 1385

Query: 446  EGRKSRKFSRLSCLRRRRHPP 466
            EG   R+  R S  RRRR PP
Sbjct: 1386 EGALRRRSLR-SHARRRRPPP 1405


>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
           [Homo sapiens]
          Length = 651

 Score = 40.4 bits (93), Expect = 0.009
 Identities = 30/140 (21%), Positives = 69/140 (49%), Gaps = 6/140 (4%)

Query: 422 ESKEPVEKE-EEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDLSEGFES 480
           + K+ V+K+ E  D E      +  + +K +K  +L    +++   K  + +D   G   
Sbjct: 321 DKKKDVKKDTESTDAESGDSKDERKDTKKDKK--KLKKDDKKKDTKKYPESTDTESGDAK 378

Query: 481 DSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTRSPTLE 540
           D+ +DS    + S +  DK  +     F  +++SE+ S+ES+ D  + ++++ +++   +
Sbjct: 379 DARNDSRNLKKASKN-DDKKKDAKKITFSTDSESELESKESQKD--EKKDKKDSKTDNKK 435

Query: 541 PPRGRSEAPDSLNGPLGPSE 560
             +   E+ D+ + P G S+
Sbjct: 436 SVKNDEESTDADSEPKGDSK 455


>gi|4759128 solute carrier family 24 (sodium/potassium/calcium
           exchanger), member 1 [Homo sapiens]
          Length = 1099

 Score = 39.7 bits (91), Expect = 0.015
 Identities = 31/152 (20%), Positives = 62/152 (40%), Gaps = 1/152 (0%)

Query: 405 EGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRH 464
           E    +P  + +   E E++E    E +P+ E    T   GE  +    +          
Sbjct: 751 ESTGEMPGEEGETAGEGETEEKSGGETQPEGEGETETQGKGEECEDENEAEGKGDNEGED 810

Query: 465 PPKVGDDSDLSEGFESDS-SHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRS 523
             ++  +    +G E ++ S + +  + G     +K +E GG +   +++ E   +E + 
Sbjct: 811 EGEIHAEDGEMKGNEGETESQELSAENHGEAKNDEKGVEDGGGSDGGDSEEEEEEEEEQE 870

Query: 524 DLEDMEEEEGTRSPTLEPPRGRSEAPDSLNGP 555
           + E+ EE+E       E     +E P SL+ P
Sbjct: 871 EEEEEEEQEEEEEEEEEEEEKGNEEPLSLDWP 902


>gi|34482047 adaptor-related protein complex 3, beta 2 subunit [Homo
           sapiens]
          Length = 1082

 Score = 39.3 bits (90), Expect = 0.019
 Identities = 37/144 (25%), Positives = 59/144 (40%), Gaps = 11/144 (7%)

Query: 430 EEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDLSEGFESDSSHDSARA 489
           EE PDP    V  +V E  K     +    R+ +  P   D    S   ES  S D    
Sbjct: 646 EEAPDPSVRNV--EVPEWTKCSNREK----RKEKEKPFYSDSEGESGPTESADS-DPESE 698

Query: 490 SEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTRSPTLEPPRGRSEAP 549
           SE     S +S  G  ++     D + + ++ R    +  EE+G R    + P  + EA 
Sbjct: 699 SESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEEDGKRKTKKKVPERKGEAS 758

Query: 550 DSLNGPLGPSEASIASNLQAMSTQ 573
            S  G    S++S +S+   M+++
Sbjct: 759 SSDEG----SDSSSSSSESEMTSE 778



 Score = 36.6 bits (83), Expect = 0.12
 Identities = 41/181 (22%), Positives = 63/181 (34%), Gaps = 15/181 (8%)

Query: 383 FTLALFSHLVNHVNIRLQAELEEGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTP 442
           F L   SHL+N      Q EL +     P       + PE  +   +E+  + E P  + 
Sbjct: 622 FQLGSLSHLLNAKATGYQ-ELPDWPEEAPDPSVRNVEVPEWTKCSNREKRKEKEKPFYSD 680

Query: 443 QVGEGRKSRKF-----SRLSCLRRRRHPPKVGDDSDLSEGFESDSSHDSARASEGSDSGS 497
             GE   +        S      +       G+ S  S+  + D   +  R SE   S  
Sbjct: 681 SEGESGPTESADSDPESESESDSKSSSESGSGESSSESDNEDQDEDEEKGRGSESEQSEE 740

Query: 498 D---------KSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTRSPTLEPPRGRSEA 548
           D            +G  ++ D  +DS  +S ES    E  EE+    S + + P     A
Sbjct: 741 DGKRKTKKKVPERKGEASSSDEGSDSSSSSSESEMTSESEEEQLEPASWSRKTPPSSKSA 800

Query: 549 P 549
           P
Sbjct: 801 P 801


>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
           sapiens]
          Length = 1152

 Score = 39.3 bits (90), Expect = 0.019
 Identities = 37/150 (24%), Positives = 59/150 (39%), Gaps = 11/150 (7%)

Query: 402 ELEEG--ENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCL 459
           E+EEG  E      + +G  E E ++  E +EE + E      +  EG + ++       
Sbjct: 726 EMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKE------- 778

Query: 460 RRRRHPPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQ 519
            R     K  ++ D  EG E ++        EG +    +  EG G   + E + E   +
Sbjct: 779 ERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEE 838

Query: 520 ESRSDLE--DMEEEEGTRSPTLEPPRGRSE 547
           E   + E  + EEEEG      E   G  E
Sbjct: 839 EGEGEEEEGEGEEEEGEGKGEEEGEEGEGE 868



 Score = 38.5 bits (88), Expect = 0.032
 Identities = 32/147 (21%), Positives = 53/147 (36%), Gaps = 30/147 (20%)

Query: 404  EEGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRR 463
            EEGE      + +G +E    E  E+E E + E      + GEG    +           
Sbjct: 968  EEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEE----------- 1016

Query: 464  HPPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRS 523
                  ++ ++    E +         EG + G ++  EG G             +E+R 
Sbjct: 1017 ------EEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEG-------------EENRR 1057

Query: 524  DLEDMEEEEGTRSPTLEPPRGRSEAPD 550
            + E+ EEEEG    T E    R +  +
Sbjct: 1058 NREEEEEEEGKYQETGEEENERQDGEE 1084



 Score = 37.7 bits (86), Expect = 0.055
 Identities = 42/165 (25%), Positives = 57/165 (34%), Gaps = 29/165 (17%)

Query: 400 QAELEEGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCL 459
           + E EEGE      +  G +E E  E  E+ EE + E      + GEG            
Sbjct: 841 EGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEE---EEGEGE----------- 886

Query: 460 RRRRHPPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQ 519
                    G++    EG E +   +     EG   G ++  EG G     E + E   +
Sbjct: 887 ---------GEEEGEGEGEEEEGEGEGEEEGEGE--GEEEEGEGKGEEEGEEGEGEGEEE 935

Query: 520 ESRSDLED----MEEEEGTRSPTLEPPRGRSEAPDSLNGPLGPSE 560
           E   + ED     EEEEG      E   G  E      G  G  E
Sbjct: 936 EGEGEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGE 980



 Score = 33.1 bits (74), Expect = 1.4
 Identities = 37/149 (24%), Positives = 61/149 (40%), Gaps = 18/149 (12%)

Query: 402 ELEEGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRR 461
           E E+GE      + +   E E KE  EKEE    +        GE ++ ++  +    + 
Sbjct: 673 EREKGEKDKGRGEMERPGEGE-KELAEKEEWKKRD--------GEEQEQKEREQ-GHQKE 722

Query: 462 RRHPPKVGDDSDLSEG--FESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQ 519
           R    + G + +  EG   E D   +  +  EG + G  + +EG     + E +     +
Sbjct: 723 RNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEG-----EREKEEGERKK 777

Query: 520 ESRSDLEDMEEEEGTRSP-TLEPPRGRSE 547
           E R+  E+  EEEG +     E   GR E
Sbjct: 778 EERAGKEEKGEEEGDQGEGEEEETEGRGE 806



 Score = 31.2 bits (69), Expect = 5.2
 Identities = 32/135 (23%), Positives = 49/135 (36%), Gaps = 23/135 (17%)

Query: 400  QAELEEGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCL 459
            + E EEGE        DG  E E +E   + EE + E        GEG +          
Sbjct: 931  EGEEEEGEGE----GEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGE---- 982

Query: 460  RRRRHPPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQ 519
                      ++    EG E +   +     EG + G  +    G    + E + E+  +
Sbjct: 983  ----------EEEGEGEGEEEEGEEEGEEEGEGEEEGEGE----GEEEEEGEVEGEVEGE 1028

Query: 520  ESRSDLEDME-EEEG 533
            E   + E+ E EEEG
Sbjct: 1029 EGEGEGEEEEGEEEG 1043


>gi|126723060 zinc finger CCCH-type containing 4 [Homo sapiens]
          Length = 1303

 Score = 39.3 bits (90), Expect = 0.019
 Identities = 31/132 (23%), Positives = 52/132 (39%), Gaps = 4/132 (3%)

Query: 421 PESKEPVEKEEEPDPEPPPV-TPQVGEGRKSRKFSRLSCLRRRRHPPKVGDDSDLSEGFE 479
           P +  P   E  P P PPP  TP         + +    L  R   P   +D +L EG  
Sbjct: 5   PGTPPPPPSESPPPPSPPPPSTPSPPPCSPDARPATPHLLHHRLPLPDDREDGELEEGEL 64

Query: 480 SDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSDLEDMEEEEGTRSPTL 539
            D   D A  ++ +  G ++S +  G    +++D E + +  +   +   E+E  RS   
Sbjct: 65  ED---DGAEETQDTSGGPERSRKEKGEKHHSDSDEEKSHRRLKRKRKKEREKEKRRSKKR 121

Query: 540 EPPRGRSEAPDS 551
              + +  A  S
Sbjct: 122 RKSKHKRHASSS 133


>gi|148763345 cell division cycle 2-like 2 isoform 4 [Homo sapiens]
          Length = 770

 Score = 38.9 bits (89), Expect = 0.025
 Identities = 32/132 (24%), Positives = 52/132 (39%), Gaps = 9/132 (6%)

Query: 405 EGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRH 464
           E    V A      ++   K          P PP    ++G+GRK  K  ++        
Sbjct: 194 EARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKME------E 247

Query: 465 PPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSD 524
              + D  D+S+     SS +S+ A  GS S  ++  E      + E  +   S+E   +
Sbjct: 248 RDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE---EEEEEEGSTSEESEEEEEE 304

Query: 525 LEDMEEEEGTRS 536
            E+ EEE G+ S
Sbjct: 305 EEEEEEETGSNS 316


>gi|148763347 cell division cycle 2-like 2 isoform 1 [Homo sapiens]
          Length = 780

 Score = 38.9 bits (89), Expect = 0.025
 Identities = 32/132 (24%), Positives = 52/132 (39%), Gaps = 9/132 (6%)

Query: 405 EGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRH 464
           E    V A      ++   K          P PP    ++G+GRK  K  ++        
Sbjct: 204 EARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKME------E 257

Query: 465 PPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSD 524
              + D  D+S+     SS +S+ A  GS S  ++  E      + E  +   S+E   +
Sbjct: 258 RDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE---EEEEEEGSTSEESEEEEEE 314

Query: 525 LEDMEEEEGTRS 536
            E+ EEE G+ S
Sbjct: 315 EEEEEEETGSNS 326


>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           9 [Homo sapiens]
          Length = 771

 Score = 38.9 bits (89), Expect = 0.025
 Identities = 32/132 (24%), Positives = 52/132 (39%), Gaps = 9/132 (6%)

Query: 405 EGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRH 464
           E    V A      ++   K          P PP    ++G+GRK  K  ++        
Sbjct: 195 EARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKME------E 248

Query: 465 PPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSD 524
              + D  D+S+     SS +S+ A  GS S  ++  E      + E  +   S+E   +
Sbjct: 249 RDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE---EEEEEEGSTSEESEEEEEE 305

Query: 525 LEDMEEEEGTRS 536
            E+ EEE G+ S
Sbjct: 306 EEEEEEETGSNS 317


>gi|16332370 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           8 [Homo sapiens]
          Length = 780

 Score = 38.9 bits (89), Expect = 0.025
 Identities = 32/132 (24%), Positives = 52/132 (39%), Gaps = 9/132 (6%)

Query: 405 EGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRH 464
           E    V A      ++   K          P PP    ++G+GRK  K  ++        
Sbjct: 204 EARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKME------E 257

Query: 465 PPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSD 524
              + D  D+S+     SS +S+ A  GS S  ++  E      + E  +   S+E   +
Sbjct: 258 RDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE---EEEEEEGSTSEESEEEEEE 314

Query: 525 LEDMEEEEGTRS 536
            E+ EEE G+ S
Sbjct: 315 EEEEEEETGSNS 326


>gi|16332364 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           5 [Homo sapiens]
          Length = 748

 Score = 38.9 bits (89), Expect = 0.025
 Identities = 32/132 (24%), Positives = 52/132 (39%), Gaps = 9/132 (6%)

Query: 405 EGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRH 464
           E    V A      ++   K          P PP    ++G+GRK  K  ++        
Sbjct: 172 EARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKME------E 225

Query: 465 PPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSD 524
              + D  D+S+     SS +S+ A  GS S  ++  E      + E  +   S+E   +
Sbjct: 226 RDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE---EEEEEEGSTSEESEEEEEE 282

Query: 525 LEDMEEEEGTRS 536
            E+ EEE G+ S
Sbjct: 283 EEEEEEETGSNS 294


>gi|16332362 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           4 [Homo sapiens]
          Length = 737

 Score = 38.9 bits (89), Expect = 0.025
 Identities = 32/132 (24%), Positives = 52/132 (39%), Gaps = 9/132 (6%)

Query: 405 EGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRH 464
           E    V A      ++   K          P PP    ++G+GRK  K  ++        
Sbjct: 161 EARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKME------E 214

Query: 465 PPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSD 524
              + D  D+S+     SS +S+ A  GS S  ++  E      + E  +   S+E   +
Sbjct: 215 RDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE---EEEEEEGSTSEESEEEEEE 271

Query: 525 LEDMEEEEGTRS 536
            E+ EEE G+ S
Sbjct: 272 EEEEEEETGSNS 283


>gi|16332358 cell division cycle 2-like 1 (PITSLRE proteins) isoform
           2 [Homo sapiens]
          Length = 782

 Score = 38.9 bits (89), Expect = 0.025
 Identities = 32/132 (24%), Positives = 52/132 (39%), Gaps = 9/132 (6%)

Query: 405 EGENPVPAFQSDGTDEPESKEPVEKEEEPDPEPPPVTPQVGEGRKSRKFSRLSCLRRRRH 464
           E    V A      ++   K          P PP    ++G+GRK  K  ++        
Sbjct: 206 EARREVSAHHRTMREDYSDKVKASHWSRSPPRPPRERFELGDGRKPVKEEKME------E 259

Query: 465 PPKVGDDSDLSEGFESDSSHDSARASEGSDSGSDKSLEGGGTAFDAETDSEMNSQESRSD 524
              + D  D+S+     SS +S+ A  GS S  ++  E      + E  +   S+E   +
Sbjct: 260 RDLLSDLQDISDSERKTSSAESSSAESGSGSEEEEEEE---EEEEEEGSTSEESEEEEEE 316

Query: 525 LEDMEEEEGTRS 536
            E+ EEE G+ S
Sbjct: 317 EEEEEEETGSNS 328


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.390 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,658,072
Number of Sequences: 37866
Number of extensions: 2047585
Number of successful extensions: 12924
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 46
Number of HSP's successfully gapped in prelim test: 326
Number of HSP's that attempted gapping in prelim test: 11284
Number of HSP's gapped (non-prelim): 1561
length of query: 1016
length of database: 18,247,518
effective HSP length: 112
effective length of query: 904
effective length of database: 14,006,526
effective search space: 12661899504
effective search space used: 12661899504
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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