Search of human proteins with 11321561

Search of human proteins with 11321561

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|11321561 hemopexin precursor [Homo sapiens]
         (462 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|11321561 hemopexin precursor [Homo sapiens]                       1007   0.0  
gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]    77   3e-14
gi|73858572 matrix metalloproteinase 12 preproprotein [Homo sapi...    72   8e-13
gi|112382270 matrix metalloproteinase 17 preproprotein [Homo sap...    70   3e-12
gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]     69   7e-12
gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprot...    69   9e-12
gi|58331148 matrix metalloproteinase 11 preproprotein [Homo sapi...    65   1e-10
gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]    65   2e-10
gi|88853069 vitronectin precursor [Homo sapiens]                       62   1e-09
gi|73808268 matrix metalloproteinase 27 [Homo sapiens]                 60   3e-09
gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]    59   7e-09
gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein ...    59   1e-08
gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]    58   2e-08
gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]    58   2e-08
gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]     58   2e-08
gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]       56   8e-08
gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [H...    56   8e-08
gi|189181724 proteoglycan 4 isoform D [Homo sapiens]                   53   5e-07
gi|189181722 proteoglycan 4 isoform C [Homo sapiens]                   53   5e-07
gi|189181720 proteoglycan 4 isoform B [Homo sapiens]                   53   5e-07
gi|67190163 proteoglycan 4 isoform A [Homo sapiens]                    53   5e-07
gi|45359865 matrix metalloproteinase 20 preproprotein [Homo sapi...    50   6e-06
gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]       49   7e-06
gi|11342666 matrix metalloproteinase 2 isoform a preproprotein [...    49   7e-06
gi|11968059 matrix metalloproteinase 25 preproprotein [Homo sapi...    49   1e-05
gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]    47   4e-05
gi|22218341 matrix metalloproteinase 21 preproprotein [Homo sapi...    43   5e-04
gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein ...    41   0.002
gi|72534732 dehydrogenase/reductase (SDR family) member 12 isofo...    41   0.002
gi|5729720 actin-like 7A [Homo sapiens]                                33   0.71 

>gi|11321561 hemopexin precursor [Homo sapiens]
          Length = 462

 Score = 1007 bits (2603), Expect = 0.0
 Identities = 462/462 (100%), Positives = 462/462 (100%)

Query: 1   MARVLGAPVALGLWSLCWSLAIATPLPPTSAHGNVAEGETKPDPDVTERCSDGWSFDATT 60
           MARVLGAPVALGLWSLCWSLAIATPLPPTSAHGNVAEGETKPDPDVTERCSDGWSFDATT
Sbjct: 1   MARVLGAPVALGLWSLCWSLAIATPLPPTSAHGNVAEGETKPDPDVTERCSDGWSFDATT 60

Query: 61  LDDNGTMLFFKGEFVWKSHKWDRELISERWKNFPSPVDAAFRQGHNSVFLIKGDKVWVYP 120
           LDDNGTMLFFKGEFVWKSHKWDRELISERWKNFPSPVDAAFRQGHNSVFLIKGDKVWVYP
Sbjct: 61  LDDNGTMLFFKGEFVWKSHKWDRELISERWKNFPSPVDAAFRQGHNSVFLIKGDKVWVYP 120

Query: 121 PEKKEKGYPKLLQDEFPGIPSPLDAAVECHRGECQAEGVLFFQGDREWFWDLATGTMKER 180
           PEKKEKGYPKLLQDEFPGIPSPLDAAVECHRGECQAEGVLFFQGDREWFWDLATGTMKER
Sbjct: 121 PEKKEKGYPKLLQDEFPGIPSPLDAAVECHRGECQAEGVLFFQGDREWFWDLATGTMKER 180

Query: 181 SWPAVGNCSSALRWLGRYYCFQGNQFLRFDPVRGEVPPRYPRDVRDYFMPCPGRGHGHRN 240
           SWPAVGNCSSALRWLGRYYCFQGNQFLRFDPVRGEVPPRYPRDVRDYFMPCPGRGHGHRN
Sbjct: 181 SWPAVGNCSSALRWLGRYYCFQGNQFLRFDPVRGEVPPRYPRDVRDYFMPCPGRGHGHRN 240

Query: 241 GTGHGNSTHHGPEYMRCSPHLVLSALTSDNHGATYAFSGTHYWRLDTSRDGWHSWPIAHQ 300
           GTGHGNSTHHGPEYMRCSPHLVLSALTSDNHGATYAFSGTHYWRLDTSRDGWHSWPIAHQ
Sbjct: 241 GTGHGNSTHHGPEYMRCSPHLVLSALTSDNHGATYAFSGTHYWRLDTSRDGWHSWPIAHQ 300

Query: 301 WPQGPSAVDAAFSWEEKLYLVQGTQVYVFLTKGGYTLVSGYPKRLEKEVGTPHGIILDSV 360
           WPQGPSAVDAAFSWEEKLYLVQGTQVYVFLTKGGYTLVSGYPKRLEKEVGTPHGIILDSV
Sbjct: 301 WPQGPSAVDAAFSWEEKLYLVQGTQVYVFLTKGGYTLVSGYPKRLEKEVGTPHGIILDSV 360

Query: 361 DAAFICPGSSRLHIMAGRRLWWLDLKSGAQATWTELPWPHEKVDGALCMEKSLGPNSCSA 420
           DAAFICPGSSRLHIMAGRRLWWLDLKSGAQATWTELPWPHEKVDGALCMEKSLGPNSCSA
Sbjct: 361 DAAFICPGSSRLHIMAGRRLWWLDLKSGAQATWTELPWPHEKVDGALCMEKSLGPNSCSA 420

Query: 421 NGPGLYLIHGPNLYCYSDVEKLNAAKALPQPQNVTSLLGCTH 462
           NGPGLYLIHGPNLYCYSDVEKLNAAKALPQPQNVTSLLGCTH
Sbjct: 421 NGPGLYLIHGPNLYCYSDVEKLNAAKALPQPQNVTSLLGCTH 462


>gi|4505205 matrix metalloproteinase 10 preproprotein [Homo sapiens]
          Length = 476

 Score = 77.4 bits (189), Expect = 3e-14
 Identities = 58/201 (28%), Positives = 95/201 (47%), Gaps = 22/201 (10%)

Query: 27  PPTSAHGNVAEGETKPD-PDVTERCSDGWSFDA-TTLDDNGTMLFFKGEFVWKSHKWDRE 84
           PP S    +   ++ P   ++  +C    SFDA +TL   G  LFFK  + W+   W+ E
Sbjct: 265 PPASTEEPLVPTKSVPSGSEMPAKCDPALSFDAISTL--RGEYLFFKDRYFWRRSHWNPE 322

Query: 85  ----LISERWKNFPSPVDAAFR-QGHNSVFLIKGDKVWVYPPEKKEKGYPKLLQD-EFPG 138
               LIS  W + PS +DAA+     ++VF+ KG++ W     + + GYP+ +    FP 
Sbjct: 323 PEFHLISAFWPSLPSYLDAAYEVNSRDTVFIFKGNEFWAIRGNEVQAGYPRGIHTLGFPP 382

Query: 139 IPSPLDAAVECHRGECQAEGVLFFQGDREWFWDLATGTMKE-------RSWPAV-GNCSS 190
               +DAAV     + + +   FF  D+ W +D  + +M++         +P V     +
Sbjct: 383 TIRKIDAAV----SDKEKKKTYFFAADKYWRFDENSQSMEQGFPRLIADDFPGVEPKVDA 438

Query: 191 ALRWLGRYYCFQGNQFLRFDP 211
            L+  G +Y F G+    FDP
Sbjct: 439 VLQAFGFFYFFSGSSQFEFDP 459



 Score = 39.3 bits (90), Expect = 0.008
 Identities = 36/138 (26%), Positives = 59/138 (42%), Gaps = 17/138 (12%)

Query: 256 RCSPHLVLSALTSDNHGATYAFSGTHYWRLDTSRDGWHSWPIAHQ----WPQGPSAVDAA 311
           +C P L   A+ S   G    F   ++WR    R  W+  P  H     WP  PS +DAA
Sbjct: 288 KCDPALSFDAI-STLRGEYLFFKDRYFWR----RSHWNPEPEFHLISAFWPSLPSYLDAA 342

Query: 312 F--SWEEKLYLVQGTQVYVFLTKGGYTLVSGYPKRLEKEVGTPHGIILDSVDAAFICPGS 369
           +  +  + +++ +G +   F    G  + +GYP+ +   +G P  I    +DAA      
Sbjct: 343 YEVNSRDTVFIFKGNE---FWAIRGNEVQAGYPRGIH-TLGFPPTI--RKIDAAVSDKEK 396

Query: 370 SRLHIMAGRRLWWLDLKS 387
            + +  A  + W  D  S
Sbjct: 397 KKTYFFAADKYWRFDENS 414


>gi|73858572 matrix metalloproteinase 12 preproprotein [Homo
           sapiens]
          Length = 470

 Score = 72.4 bits (176), Expect = 8e-13
 Identities = 57/194 (29%), Positives = 85/194 (43%), Gaps = 14/194 (7%)

Query: 30  SAHGNVAEGETKPDPDVTER--CSDGWSFDATTLDDNGTMLFFKGEFVW----KSHKWDR 83
           S +G+  E +  P+PD +E   C    SFDA T   N  + FFK  F W    +  K   
Sbjct: 260 SLYGDPKENQRLPNPDNSEPALCDPNLSFDAVTTVGN-KIFFFKDRFFWLKVSERPKTSV 318

Query: 84  ELISERWKNFPSPVDAAFR-QGHNSVFLIKGDKVWVYPPEKKEKGYPKLLQD-EFPGIPS 141
            LIS  W   PS ++AA+  +  N VFL K DK W+    + E  YPK +    FP    
Sbjct: 319 NLISSLWPTLPSGIEAAYEIEARNQVFLFKDDKYWLISNLRPEPNYPKSIHSFGFPNFVK 378

Query: 142 PLDAAV---ECHRGECQAEGVLFFQGDREWFWDLATGTMKERSWPAVGNCSSALRWLGR- 197
            +DAAV     +R     +   +   +R    D     +  +++  +G    A+ +    
Sbjct: 379 KIDAAVFNPRFYRTYFFVDNQYWRYDERRQMMDPGYPKLITKNFQGIGPKIDAVFYSKNK 438

Query: 198 -YYCFQGNQFLRFD 210
            YY FQG+    +D
Sbjct: 439 YYYFFQGSNQFEYD 452



 Score = 36.6 bits (83), Expect = 0.049
 Identities = 34/134 (25%), Positives = 55/134 (41%), Gaps = 17/134 (12%)

Query: 257 CSPHLVLSALTSDNHGATYAFSGTHYWRLDTSRDGWHSWPIAHQWPQGPSAVDAAFSWEE 316
           C P+L   A+T+  +   + F    +W   + R       I+  WP  PS ++AA+  E 
Sbjct: 282 CDPNLSFDAVTTVGN-KIFFFKDRFFWLKVSERPKTSVNLISSLWPTLPSGIEAAYEIEA 340

Query: 317 KLYLVQGTQVYVFLTKGGYTLVS------GYPKRLEKEVGTPHGIILDSVDAAFICPGSS 370
           +       QV++F     Y L+S       YPK +    G P+   +  +DAA   P   
Sbjct: 341 R------NQVFLF-KDDKYWLISNLRPEPNYPKSIH-SFGFPN--FVKKIDAAVFNPRFY 390

Query: 371 RLHIMAGRRLWWLD 384
           R +     + W  D
Sbjct: 391 RTYFFVDNQYWRYD 404


>gi|112382270 matrix metalloproteinase 17 preproprotein [Homo
           sapiens]
          Length = 603

 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 61/209 (29%), Positives = 89/209 (42%), Gaps = 28/209 (13%)

Query: 42  PDPDVTERCSDGWSFDATTLDDNGTMLFFKGEFVWKSHKWDRELISER-------WKNFP 94
           P  DV  RCS    FDA      G   FFKG++ W+  + DR L+S +       W+  P
Sbjct: 324 PRKDVPHRCST--HFDAVA-QIRGEAFFFKGKYFWRLTR-DRHLVSLQPAQMHRFWRGLP 379

Query: 95  ---SPVDAAF-RQGHNSVFLIKGDKVWVYPPEKKEKGYPKLLQDEFPGIPSPLDAAVECH 150
                VDA + R   + +   KGD+ WV+     E+GYP+ + D F   P  +DAA    
Sbjct: 380 LHLDSVDAVYERTSDHKIVFFKGDRYWVFKDNNVEEGYPRPVSD-FSLPPGGIDAAFSW- 437

Query: 151 RGECQAEGVLFFQGDREWFWDLATGTM------KERSWPAV-GNCSSALRWL-GRYYCFQ 202
                 +   FF+    W +D  T  M      +   W  V      A+RW  G  Y F+
Sbjct: 438 ---AHNDRTYFFKDQLYWRYDDHTRHMDPGYPAQSPLWRGVPSTLDDAMRWSDGASYFFR 494

Query: 203 GNQFLRFDPVRGEVPPRYPRDVRDYFMPC 231
           G ++ +      EV P YP+     ++ C
Sbjct: 495 GQEYWKVLDGELEVAPGYPQSTARDWLVC 523



 Score = 33.1 bits (74), Expect = 0.55
 Identities = 35/136 (25%), Positives = 54/136 (39%), Gaps = 18/136 (13%)

Query: 256 RCSPHLVLSALTSDNHGATYAFSGTHYWRLDTSRDGWHSWPI-AHQW----PQGPSAVDA 310
           RCS H    A      G  + F G ++WRL   R      P   H++    P    +VDA
Sbjct: 331 RCSTHFDAVAQI---RGEAFFFKGKYFWRLTRDRHLVSLQPAQMHRFWRGLPLHLDSVDA 387

Query: 311 AF--SWEEKLYLVQGTQVYVFLTKGGYTLVSGYPKRLEKEVGTPHGIILDSVDAAFICPG 368
            +  + + K+   +G + +VF       +  GYP+ +      P GI     DAAF    
Sbjct: 388 VYERTSDHKIVFFKGDRYWVFKDN---NVEEGYPRPVSDFSLPPGGI-----DAAFSWAH 439

Query: 369 SSRLHIMAGRRLWWLD 384
           + R +    +  W  D
Sbjct: 440 NDRTYFFKDQLYWRYD 455


>gi|4505217 matrix metalloproteinase 3 preproprotein [Homo sapiens]
          Length = 477

 Score = 69.3 bits (168), Expect = 7e-12
 Identities = 59/203 (29%), Positives = 86/203 (42%), Gaps = 29/203 (14%)

Query: 24  TPLPPTSAHGNVAEGETKPDPDVTERCSDGWSFDA-TTLDDNGTMLFFKGEFVWKS--HK 80
           TPL PT            P+P     C    SFDA +TL   G +L FK    W+    K
Sbjct: 272 TPLVPTEP--------VPPEPGTPANCDPALSFDAVSTL--RGEILIFKDRHFWRKSLRK 321

Query: 81  WDREL--ISERWKNFPSPVDAAFR-QGHNSVFLIKGDKVWVYPPEKKEKGYPKLLQD-EF 136
            + EL  IS  W + PS VDAA+     + VF+ KG++ W     +   GYP+ +    F
Sbjct: 322 LEPELHLISSFWPSLPSGVDAAYEVTSKDLVFIFKGNQFWAIRGNEVRAGYPRGIHTLGF 381

Query: 137 PGIPSPLDAAVECHRGECQAEGVLFFQGDREWFWDLATGTMK-------ERSWPAV-GNC 188
           P     +DAA+     + +     FF  D+ W +D    +M+          +P +    
Sbjct: 382 PPTVRKIDAAI----SDKEKNKTYFFVEDKYWRFDEKRNSMEPGFPKQIAEDFPGIDSKI 437

Query: 189 SSALRWLGRYYCFQGNQFLRFDP 211
            +     G +Y F G+  L FDP
Sbjct: 438 DAVFEEFGFFYFFTGSSQLEFDP 460



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 35/132 (26%), Positives = 55/132 (41%), Gaps = 9/132 (6%)

Query: 257 CSPHLVLSALTSDNHGATYAFSGTHYWRLDTSRDGWHSWPIAHQWPQGPSAVDAAFSWEE 316
           C P L   A+ S   G    F   H+WR    +       I+  WP  PS VDAA+    
Sbjct: 290 CDPALSFDAV-STLRGEILIFKDRHFWRKSLRKLEPELHLISSFWPSLPSGVDAAYEVTS 348

Query: 317 K--LYLVQGTQVYVFLTKGGYTLVSGYPKRLEKEVGTPHGIILDSVDAAFICPGSSRLHI 374
           K  +++ +G Q   F    G  + +GYP+ +   +G P  +    +DAA      ++ + 
Sbjct: 349 KDLVFIFKGNQ---FWAIRGNEVRAGYPRGIH-TLGFPPTV--RKIDAAISDKEKNKTYF 402

Query: 375 MAGRRLWWLDLK 386
               + W  D K
Sbjct: 403 FVEDKYWRFDEK 414



 Score = 30.4 bits (67), Expect = 3.5
 Identities = 28/99 (28%), Positives = 39/99 (39%), Gaps = 7/99 (7%)

Query: 234 RGHGHRNGTGHGNSTHHGPEYMRCSPHLVLSALTSDNHGATYAFSGTHYWRLDTSRDGWH 293
           RG+  R G   G  T   P  +R     + +A++      TY F    YWR D  R+   
Sbjct: 364 RGNEVRAGYPRGIHTLGFPPTVR----KIDAAISDKEKNKTYFFVEDKYWRFDEKRNSME 419

Query: 294 -SWP--IAHQWPQGPSAVDAAFSWEEKLYLVQGTQVYVF 329
             +P  IA  +P   S +DA F      Y   G+    F
Sbjct: 420 PGFPKQIAEDFPGIDSKIDAVFEEFGFFYFFTGSSQLEF 458


>gi|4505213 matrix metalloproteinase 19 isoform rasi-1 preproprotein
           [Homo sapiens]
          Length = 508

 Score = 68.9 bits (167), Expect = 9e-12
 Identities = 68/225 (30%), Positives = 92/225 (40%), Gaps = 33/225 (14%)

Query: 40  TKPDPDVTERCSDGWSFDATTLDDNGTMLFFKGEFVWK---SHKWDRELISERWKNFPSP 96
           T+P P + + CS     DA  L   G    FKG++VW    S       +S  W+  P  
Sbjct: 280 TEPSP-MPDPCSS--ELDAMMLGPRGKTYAFKGDYVWTVSDSGPGPLFRVSALWEGLPGN 336

Query: 97  VDAAFRQGHNS-VFLIKGDKVWVYPPEKKEKGYPKLLQDEFPGIPSPLDAAVECHRGECQ 155
           +DAA        +   KGDKVW Y   K   G+PK L    P     LDAA+        
Sbjct: 337 LDAAVYSPRTQWIHFFKGDKVWRYINFKMSPGFPKKLNRVEPN----LDAALYWPLN--- 389

Query: 156 AEGVLFFQGDREWFWD-LATGTMKERSWPAVG-------NCSSALRWL-GRYYCFQGNQF 206
            + V  F+G   W WD LA         P  G         S+A+ W  GR Y F+G  +
Sbjct: 390 -QKVFLFKGSGYWQWDELARTDFSSYPKPIKGLFTGVPNQPSAAMSWQDGRVYFFKGKVY 448

Query: 207 LRFDPVRGEVPPRYPRDVRDYFMPC--------PGRGHGHRNGTG 243
            R +  +  V   YPR++   +M C        P  G+   +GTG
Sbjct: 449 WRLNQ-QLRVEKGYPRNISHNWMHCRPRTIDTTPSGGNTTPSGTG 492



 Score = 39.7 bits (91), Expect = 0.006
 Identities = 33/140 (23%), Positives = 64/140 (45%), Gaps = 18/140 (12%)

Query: 263 LSALTSDNHGATYAFSGTHYWRLDTSRDGWHSWPIAHQWPQGPSAVDAAF--SWEEKLYL 320
           L A+     G TYAF G + W +  S  G   + ++  W   P  +DAA      + ++ 
Sbjct: 293 LDAMMLGPRGKTYAFKGDYVWTVSDSGPG-PLFRVSALWEGLPGNLDAAVYSPRTQWIHF 351

Query: 321 VQGTQVYVFLTKGGYTLVSGYPKRLEKEVGTPHGIILDSVDAAFICPGSSRLHIMAGRRL 380
            +G +V+ ++    + +  G+PK+L +        +  ++DAA   P + ++ +  G   
Sbjct: 352 FKGDKVWRYI---NFKMSPGFPKKLNR--------VEPNLDAALYWPLNQKVFLFKGSGY 400

Query: 381 W-WLDLKSGAQATWTELPWP 399
           W W +L   A+  ++  P P
Sbjct: 401 WQWDEL---ARTDFSSYPKP 417


>gi|58331148 matrix metalloproteinase 11 preproprotein [Homo
           sapiens]
          Length = 488

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 59/210 (28%), Positives = 87/210 (41%), Gaps = 24/210 (11%)

Query: 35  VAEGETKPDPDVTERCSDGWSFDATTLDDNGTMLFFKGEFVWKSHKWDRE-----LISER 89
           +A  E    PD  E      SFDA +    G + FFK  FVW+      +     L S  
Sbjct: 282 IAPLEPDAPPDACEA-----SFDAVSTI-RGELFFFKAGFVWRLRGGQLQPGYPALASRH 335

Query: 90  WKNFPSPVDAAFRQGHNSVFLIKGDKVWVYPPEKKEKGYPKLLQDEFPGIPSPLDAAVEC 149
           W+  PSPVDAAF      ++  +G + WVY  EK   G   L   E   +  P+ AA+  
Sbjct: 336 WQGLPSPVDAAFEDAQGHIWFFQGAQYWVYDGEKPVLGPAPL--TELGLVRFPVHAALVW 393

Query: 150 HRGECQAEGVLFFQGDREWFWDLATGTM------KERSWPAV-GNCSSALRWLGRY-YCF 201
                +   + FF+G   W +  +T  +      +   W  V     +A +    Y Y  
Sbjct: 394 GP---EKNKIYFFRGRDYWRFHPSTRRVDSPVPRRATDWRGVPSEIDAAFQDADGYAYFL 450

Query: 202 QGNQFLRFDPVRGEVPPRYPRDVRDYFMPC 231
           +G  + +FDPV+ +    +PR V   F  C
Sbjct: 451 RGRLYWKFDPVKVKALEGFPRLVGPDFFGC 480


>gi|4505211 matrix metalloproteinase 15 preproprotein [Homo sapiens]
          Length = 669

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 63/233 (27%), Positives = 91/233 (39%), Gaps = 34/233 (14%)

Query: 25  PLPPTSAHGNVAEGETKPDPDVTERCSD----------GWSFDATTLDDNGTMLFFKGEF 74
           P PP    G   E   KP P V  R ++             FD   +   G M  FKG +
Sbjct: 335 PQPPPP--GGKPERPPKPGPPVQPRATERPDQYGPNICDGDFDTVAML-RGEMFVFKGRW 391

Query: 75  VWKSHKWDREL------ISERWKNFPSPVDAAFRQGHNSVFLIKGDKVWVYPPEKKEKGY 128
            W+  + +R L      I   W+  P  + AA+ +        KGD+ W++     E GY
Sbjct: 392 FWRV-RHNRVLDNYPMPIGHFWRGLPGDISAAYERQDGRFVFFKGDRYWLFREANLEPGY 450

Query: 129 PKLLQDEFPGIP-SPLDAAVECHRGECQAEGVLFFQGDREWFWDLAT-----GTMKERS- 181
           P+ L     GIP   +D A+             FFQ DR W ++  T     G  K  S 
Sbjct: 451 PQPLTSYGLGIPYDRIDTAIWWE----PTGHTFFFQEDRYWRFNEETQRGDPGYPKPISV 506

Query: 182 W---PAVGNCSSALRWLGRYYCFQGNQFLRFDPVRGEVPPRYPRDVRDYFMPC 231
           W   PA    +         Y ++G ++ +FD  R  + P YP+ +   FM C
Sbjct: 507 WQGIPASPKGAFLSNDAAYTYFYKGTKYWKFDNERLRMEPGYPKSILRDFMGC 559


>gi|88853069 vitronectin precursor [Homo sapiens]
          Length = 478

 Score = 61.6 bits (148), Expect = 1e-09
 Identities = 42/136 (30%), Positives = 65/136 (47%), Gaps = 9/136 (6%)

Query: 41  KPDPDVTERCSDGWSFDATTLDDNGTMLFFKGEFVWK-SHKWDR----ELISERWKNFPS 95
           +P P   E    G  FDA T   NG++  F+G++ ++   K  R    +LI + W     
Sbjct: 146 RPQPPAEEELCSGKPFDAFTDLKNGSLFAFRGQYCYELDEKAVRPGYPKLIRDVW-GIEG 204

Query: 96  PVDAAFRQGH--NSVFLIKGDKVWVYPPEKKEKGYPKLLQDEFPGIPSPLDAAVECHRGE 153
           P+DAAF + +     +L KG + W +     +  YP+ + D F GIP  +DAA+      
Sbjct: 205 PIDAAFTRINCQGKTYLFKGSQYWRFEDGVLDPDYPRNISDGFDGIPDNVDAALALPAHS 264

Query: 154 CQA-EGVLFFQGDREW 168
               E V FF+G + W
Sbjct: 265 YSGRERVYFFKGKQYW 280



 Score = 40.8 bits (94), Expect = 0.003
 Identities = 36/137 (26%), Positives = 53/137 (38%), Gaps = 45/137 (32%)

Query: 96  PVDAAFRQGHNSVFLIKGDKVWVYPPEKKEKGYPKLLQDEFPGIPSPLDAAVECHRGECQ 155
           P DA     + S+F  +G   +    +    GYPKL++D + GI  P+DAA    R  CQ
Sbjct: 160 PFDAFTDLKNGSLFAFRGQYCYELDEKAVRPGYPKLIRDVW-GIEGPIDAAFT--RINCQ 216

Query: 156 AEGVLFFQGDREWFWDLATGTMKERSWPAVGNCSSALRWLGRYYCFQGNQFLRFDPVRGE 215
                                                   G+ Y F+G+Q+ RF+   G 
Sbjct: 217 ----------------------------------------GKTYLFKGSQYWRFED--GV 234

Query: 216 VPPRYPRDVRDYFMPCP 232
           + P YPR++ D F   P
Sbjct: 235 LDPDYPRNISDGFDGIP 251



 Score = 31.2 bits (69), Expect = 2.1
 Identities = 21/66 (31%), Positives = 31/66 (46%), Gaps = 8/66 (12%)

Query: 272 GATYAFSGTHYWRL-DTSRDGWHSWPIAHQWPQGPSAVDAA-------FSWEEKLYLVQG 323
           G TY F G+ YWR  D   D  +   I+  +   P  VDAA       +S  E++Y  +G
Sbjct: 217 GKTYLFKGSQYWRFEDGVLDPDYPRNISDGFDGIPDNVDAALALPAHSYSGRERVYFFKG 276

Query: 324 TQVYVF 329
            Q + +
Sbjct: 277 KQYWEY 282



 Score = 29.6 bits (65), Expect = 6.0
 Identities = 10/21 (47%), Positives = 13/21 (61%)

Query: 216 VPPRYPRDVRDYFMPCPGRGH 236
           V P YPR +  Y++ CP  GH
Sbjct: 457 VDPPYPRSIAQYWLGCPAPGH 477


>gi|73808268 matrix metalloproteinase 27 [Homo sapiens]
          Length = 513

 Score = 60.5 bits (145), Expect = 3e-09
 Identities = 49/195 (25%), Positives = 86/195 (44%), Gaps = 19/195 (9%)

Query: 30  SAHGNVAEGETKP-DPDVTERCSDGWSFDATTLDDNGTMLFFKGEFVWKSH----KWDRE 84
           S +G + +   KP +P +   C    +FDA T      M FFKG  +W+ +      + E
Sbjct: 258 SIYGGLPKEPAKPKEPTIPHACDPDLTFDAITTFRREVM-FFKGRHLWRIYYDITDVEFE 316

Query: 85  LISERWKNFPSPVDAAFRQGHNSVFLIKGDKVWVYPPEKKEKGYPKLLQD-EFPGIPSPL 143
           LI+  W + P+ + AA+    + + + K +  W+         YPK +    FPG    +
Sbjct: 317 LIASFWPSLPADLQAAYENPRDKILVFKDENFWMIRGYAVLPDYPKSIHTLGFPGRVKKI 376

Query: 144 DAAVECHRGECQAEGVLFFQGDREWFWDLATGTMKE-------RSWPAVG-NCSSALRWL 195
           DAAV C +         FF G   W +D  T TM +       + +P +     +A ++ 
Sbjct: 377 DAAV-CDK---TTRKTYFFVGIWCWRFDEMTQTMDKGFPQRVVKHFPGISIRVDAAFQYK 432

Query: 196 GRYYCFQGNQFLRFD 210
           G ++  +G++   +D
Sbjct: 433 GFFFFSRGSKQFEYD 447


>gi|5729929 matrix metalloproteinase 24 preproprotein [Homo sapiens]
          Length = 645

 Score = 59.3 bits (142), Expect = 7e-09
 Identities = 53/215 (24%), Positives = 81/215 (37%), Gaps = 33/215 (15%)

Query: 38  GETKPDPDVTERCSDGWSFDATTLDDNGTMLFFKGEFVWKSHKWDRE-----LISERWKN 92
           G+    P       DG +F+   L   G M  FK  + W+      +      I + WK 
Sbjct: 367 GDRPSTPGTKPNICDG-NFNTVALF-RGEMFVFKDRWFWRLRNNRVQEGYPMQIEQFWKG 424

Query: 93  FPSPVDAAFRQGHNSVFLIKGDKVWVYPPEKKEKGYPKLLQDEFPGIP-SPLDAAVECHR 151
            P+ +DAA+ +        KGDK WV+     E GYP  L +    +P   +D A+    
Sbjct: 425 LPARIDAAYERADGRFVFFKGDKYWVFKEVTVEPGYPHSLGELGSCLPREGIDTALRWE- 483

Query: 152 GECQAEGVLFFQGDREWFWDLATGTMKERSWPAVGNCSSALRWLG--------------- 196
                    FF+G+R W +       +ER     G       W G               
Sbjct: 484 ---PVGKTYFFKGERYWRYS------EERRATDPGYPKPITVWKGIPQAPQGAFISKEGY 534

Query: 197 RYYCFQGNQFLRFDPVRGEVPPRYPRDVRDYFMPC 231
             Y ++G  + +FD  +  V P YPR++   +M C
Sbjct: 535 YTYFYKGRDYWKFDNQKLSVEPGYPRNILRDWMGC 569



 Score = 37.0 bits (84), Expect = 0.038
 Identities = 50/205 (24%), Positives = 75/205 (36%), Gaps = 45/205 (21%)

Query: 158 GVLFFQGDREWFWDLATGTMKE-------RSWPAVGNCSSAL--RWLGRYYCFQGNQFLR 208
           G +F   DR WFW L    ++E       + W  +     A   R  GR+  F+G+++  
Sbjct: 392 GEMFVFKDR-WFWRLRNNRVQEGYPMQIEQFWKGLPARIDAAYERADGRFVFFKGDKYWV 450

Query: 209 FDPVRGEVPPRYPRDVRDYFMPCPGRGHGHRNGTGHGNSTHHGPEYMRCSPHLVLSALTS 268
           F  V   V P YP  + +     P  G                          + +AL  
Sbjct: 451 FKEVT--VEPGYPHSLGELGSCLPREG--------------------------IDTALRW 482

Query: 269 DNHGATYAFSGTHYWRLDTSR---DGWHSWPIAHQWPQGPSAVDAAFSWEE--KLYLVQG 323
           +  G TY F G  YWR    R   D  +  PI   W   P A   AF  +E    Y  +G
Sbjct: 483 EPVGKTYFFKGERYWRYSEERRATDPGYPKPIT-VWKGIPQAPQGAFISKEGYYTYFYKG 541

Query: 324 TQVYVFLTKGGYTLVSGYPKRLEKE 348
              + F      ++  GYP+ + ++
Sbjct: 542 RDYWKF-DNQKLSVEPGYPRNILRD 565


>gi|13027802 matrix metalloproteinase 16 isoform 1 preproprotein
           [Homo sapiens]
          Length = 607

 Score = 58.5 bits (140), Expect = 1e-08
 Identities = 46/183 (25%), Positives = 75/183 (40%), Gaps = 21/183 (11%)

Query: 67  MLFFKGEFVWKSHKWDREL------ISERWKNFPSPVDAAFRQGHNSVFLIKGDKVWVYP 120
           M  FK ++ W+    +R +      I+  W+  P  +DA +     +    KG+K WV+ 
Sbjct: 357 MFVFKDQWFWRVRN-NRVMDGYPMQITYFWRGLPPSIDAVYENSDGNFVFFKGNKYWVFK 415

Query: 121 PEKKEKGYPKLLQDEFPGI-PSPLDAAVECHRGECQAEGVLFFQGDREWFWDLATGTMKE 179
               + GYP  L     GI P  +D+A+             FF+GDR W +     TM  
Sbjct: 416 DTTLQPGYPHDLITLGSGIPPHGIDSAIWWE----DVGKTYFFKGDRYWRYSEEMKTMDP 471

Query: 180 ---------RSWPAVGNCSSALRWLGRYYCFQGNQFLRFDPVRGEVPPRYPRDVRDYFMP 230
                    +  P     +   +  G  Y ++G ++ +F+    +V P YPR +   FM 
Sbjct: 472 GYPKPITVWKGIPESPQGAFVHKENGFTYFYKGKEYWKFNNQILKVEPGYPRSILKDFMG 531

Query: 231 CPG 233
           C G
Sbjct: 532 CDG 534



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 27/98 (27%), Positives = 40/98 (40%), Gaps = 9/98 (9%)

Query: 62  DDNGTMLFFKGEFVWKSHKWDRELISER------WKNFPSPVDAAFRQGHNS-VFLIKGD 114
           +D G   FFKG+  W+  +  + +          WK  P     AF    N   +  KG 
Sbjct: 446 EDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPITVWKGIPESPQGAFVHKENGFTYFYKGK 505

Query: 115 KVWVYPPE--KKEKGYPKLLQDEFPGIPSPLDAAVECH 150
           + W +  +  K E GYP+ +  +F G   P D   E H
Sbjct: 506 EYWKFNNQILKVEPGYPRSILKDFMGCDGPTDRVKEGH 543



 Score = 34.3 bits (77), Expect = 0.24
 Identities = 27/95 (28%), Positives = 42/95 (44%), Gaps = 7/95 (7%)

Query: 259 PHLVLSALTSDNHGATYAFSGTHYWRLD---TSRDGWHSWPIAHQWPQGPSAVDAAFSWE 315
           PH + SA+  ++ G TY F G  YWR      + D  +  PI   W   P +   AF  +
Sbjct: 436 PHGIDSAIWWEDVGKTYFFKGDRYWRYSEEMKTMDPGYPKPIT-VWKGIPESPQGAFVHK 494

Query: 316 EK--LYLVQGTQVYVFLTKGGYTLVSGYPKRLEKE 348
           E    Y  +G + + F       +  GYP+ + K+
Sbjct: 495 ENGFTYFYKGKEYWKF-NNQILKVEPGYPRSILKD 528


>gi|4826834 matrix metalloproteinase 14 preproprotein [Homo sapiens]
          Length = 582

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 55/229 (24%), Positives = 101/229 (44%), Gaps = 29/229 (12%)

Query: 25  PLPPTSAHGNVAEGETKP-DPDVTERCSDGWSFDATTLDDNGTMLFFKGEFVWKSHKWD- 82
           P P T++  +V +   KP +P       DG +FD   +   G M  FK  + W+      
Sbjct: 295 PQPRTTSRPSVPD---KPKNPTYGPNICDG-NFDTVAML-RGEMFVFKERWFWRVRNNQV 349

Query: 83  ----RELISERWKNFPSPVDAAFRQGHNSVFLIKGDKVWVYPPEKKEKGYPKLLQDEFPG 138
                  I + W+  P+ ++ A+ +        KGDK WV+     E GYPK +++   G
Sbjct: 350 MDGYPMPIGQFWRGLPASINTAYERKDGKFVFFKGDKHWVFDEASLEPGYPKHIKELGRG 409

Query: 139 IPS-PLDAAV-ECHRGECQAEGVLFFQGDREWFWDLATGTMKE------RSWPAVGNCSS 190
           +P+  +DAA+     G+       FF+G++ + ++     +        + W  +   S 
Sbjct: 410 LPTDKIDAALFWMPNGK-----TYFFRGNKYYRFNEELRAVDSEYPKNIKVWEGIPE-SP 463

Query: 191 ALRWLGR----YYCFQGNQFLRFDPVRGEVPPRYPRDVRDYFMPCPGRG 235
              ++G      Y ++GN++ +F+  + +V P YP+     +M CP  G
Sbjct: 464 RGSFMGSDEVFTYFYKGNKYWKFNNQKLKVEPGYPKSALRDWMGCPSGG 512


>gi|4505209 matrix metalloproteinase 13 preproprotein [Homo sapiens]
          Length = 471

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 51/188 (27%), Positives = 76/188 (40%), Gaps = 19/188 (10%)

Query: 30  SAHGNVAEGETKPDPDVTERCSDGWSFDATTLDDNGTMLFFKGEFVWKSH--KWDRELIS 87
           S +G   E      P   ++C    S DA T     TM+F K  F W+ H  + D EL  
Sbjct: 264 SLYGPGDEDPNPKHPKTPDKCDPSLSLDAITSLRGETMIF-KDRFFWRLHPQQVDAELFL 322

Query: 88  ER--WKNFPSPVDAAFRQ-GHNSVFLIKGDKVWVYPPEKKEKGYPKLLQD-EFPGIPSPL 143
            +  W   P+ +DAA+    H+ +F+ +G K W        +GYPK + +   P     +
Sbjct: 323 TKSFWPELPNRIDAAYEHPSHDLIFIFRGRKFWALNGYDILEGYPKKISELGLPKEVKKI 382

Query: 144 DAAVECHRGECQAEGVLFFQGDREWFWDLATGTMK-------ERSWPAVGNCSSALRWLG 196
            AAV            L F G++ W +D     M        E  +P +G+   A+    
Sbjct: 383 SAAVHFE----DTGKTLLFSGNQVWRYDDTNHIMDKDYPRLIEEDFPGIGDKVDAVYEKN 438

Query: 197 RY-YCFQG 203
            Y Y F G
Sbjct: 439 GYIYFFNG 446



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 35/131 (26%), Positives = 63/131 (48%), Gaps = 9/131 (6%)

Query: 256 RCSPHLVLSALTSDNHGATYAFSGTHYWRLDTSRDGWHSWPIAHQWPQGPSAVDAAFSW- 314
           +C P L L A+TS   G T  F    +WRL   +     +     WP+ P+ +DAA+   
Sbjct: 283 KCDPSLSLDAITS-LRGETMIFKDRFFWRLHPQQVDAELFLTKSFWPELPNRIDAAYEHP 341

Query: 315 -EEKLYLVQGTQVYVFLTKGGYTLVSGYPKRLEKEVGTPHGIILDSVDAAFICPGSSRLH 373
             + +++ +G +   F    GY ++ GYPK++  E+G P  +    + AA     + +  
Sbjct: 342 SHDLIFIFRGRK---FWALNGYDILEGYPKKI-SELGLPKEV--KKISAAVHFEDTGKTL 395

Query: 374 IMAGRRLWWLD 384
           + +G ++W  D
Sbjct: 396 LFSGNQVWRYD 406


>gi|4505221 matrix metalloproteinase 8 preproprotein [Homo sapiens]
          Length = 467

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 42/135 (31%), Positives = 65/135 (48%), Gaps = 15/135 (11%)

Query: 44  PDVTERCSDGWSFDA-TTLDDNGTMLFFKGEFVWKSH----KWDRELISERWKNFPSPVD 98
           P   + C    +FDA TTL   G +LFFK  + W+ H    + +   IS  W + P+ + 
Sbjct: 273 PSTPKPCDPSLTFDAITTL--RGEILFFKDRYFWRRHPQLQRVEMNFISLFWPSLPTGIQ 330

Query: 99  AAFRQ-GHNSVFLIKGDKVWVYPPEKKEKGYPKLLQD-EFPGIPSPLDAAVECHRGECQA 156
           AA+     + +FL KG++ W        +GYPK + +  FP     +DAAV  +R +   
Sbjct: 331 AAYEDFDRDLIFLFKGNQYWALSGYDILQGYPKDISNYGFPSSVQAIDAAV-FYRSK--- 386

Query: 157 EGVLFFQGDREWFWD 171
               FF  D+ W +D
Sbjct: 387 --TYFFVNDQFWRYD 399



 Score = 32.0 bits (71), Expect = 1.2
 Identities = 54/218 (24%), Positives = 82/218 (37%), Gaps = 60/218 (27%)

Query: 132 LQDEFPGIPSPLDA-----AVECHRGECQAEGVLFFQGDREWFW----DLATGTMKERS- 181
           +Q   P  P P D      A+   RGE     +LFF+ DR +FW     L    M   S 
Sbjct: 268 IQPTGPSTPKPCDPSLTFDAITTLRGE-----ILFFK-DR-YFWRRHPQLQRVEMNFISL 320

Query: 182 -WPAVGN-CSSALRWLGR--YYCFQGNQFLR---FDPVRGEVPPRYPRDVRDYFMPCPGR 234
            WP++     +A     R   + F+GNQ+     +D ++G     YP+D+ +Y  P    
Sbjct: 321 FWPSLPTGIQAAYEDFDRDLIFLFKGNQYWALSGYDILQG-----YPKDISNYGFPS--- 372

Query: 235 GHGHRNGTGHGNSTHHGPEYMRCSPHLVLSALTSDNHGATYAFSGTHYWRLDTSR---DG 291
                                  S   + +A+       TY F    +WR D  R   + 
Sbjct: 373 -----------------------SVQAIDAAVFY--RSKTYFFVNDQFWRYDNQRQFMEP 407

Query: 292 WHSWPIAHQWPQGPSAVDAAFSWEEKLYLVQGTQVYVF 329
            +   I+  +P   S VDA F  E   ++  G + Y F
Sbjct: 408 GYPKSISGAFPGIESKVDAVFQQEHFFHVFSGPRYYAF 445


>gi|225543094 matrix metalloproteinase 1 isoform 2 [Homo sapiens]
          Length = 403

 Score = 55.8 bits (133), Expect = 8e-08
 Identities = 48/183 (26%), Positives = 78/183 (42%), Gaps = 20/183 (10%)

Query: 44  PDVTERCSDGWSFDATTLDDNGTMLFFKGEFVWKSHKWDREL----ISERWKNFPSPVDA 99
           P   + C    +FDA T    G ++FFK  F  +++ +  E+    IS  W   P+ ++A
Sbjct: 206 PQTPKACDSKLTFDAITTI-RGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEA 264

Query: 100 AFR-QGHNSVFLIKGDKVWVYPPEKKEKGYPKLLQDEF--PGIPSPLDAAVECHRGECQA 156
           A+     + V   KG+K W    +    GYPK +   F  P     +DAA+     E   
Sbjct: 265 AYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALS----EENT 320

Query: 157 EGVLFFQGDREWFWDLATGTMKE-------RSWPAVGNCSSALRWL-GRYYCFQGNQFLR 208
               FF  ++ W +D    +M           +P +G+   A+    G +Y F G +  +
Sbjct: 321 GKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYK 380

Query: 209 FDP 211
           FDP
Sbjct: 381 FDP 383



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 26/69 (37%), Positives = 33/69 (47%), Gaps = 3/69 (4%)

Query: 264 SALTSDNHGATYAFSGTHYWRLD---TSRDGWHSWPIAHQWPQGPSAVDAAFSWEEKLYL 320
           +AL+ +N G TY F    YWR D    S D  +   IAH +P     VDA F  +   Y 
Sbjct: 313 AALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYF 372

Query: 321 VQGTQVYVF 329
             GT+ Y F
Sbjct: 373 FHGTRQYKF 381



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 38/137 (27%), Positives = 58/137 (42%), Gaps = 26/137 (18%)

Query: 63  DNGTMLFFKGEFVWKS------HKWDRELISERWKNFPSPV---DAAFRQGHNS-VFLIK 112
           D   + FFKG   W        H + +++ S     FP  V   DAA  + +    +   
Sbjct: 270 DRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSF--GFPRTVKHIDAALSEENTGKTYFFV 327

Query: 113 GDKVWVYPPEKK--EKGYPKLLQDEFPGIPSPLDAAVECHRGECQAEGVL-FFQGDREWF 169
            +K W Y   K+  + GYPK++  +FPGI   +DA           +G   FF G R++ 
Sbjct: 328 ANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVF-------MKDGFFYFFHGTRQYK 380

Query: 170 WDLATGTM----KERSW 182
           +D  T  +    K  SW
Sbjct: 381 FDPKTKRILTLQKANSW 397



 Score = 34.7 bits (78), Expect = 0.19
 Identities = 30/137 (21%), Positives = 56/137 (40%), Gaps = 9/137 (6%)

Query: 251 GPEYMR-CSPHLVLSALTSDNHGATYAFSGTHYWRLDTSRDGWHSWPIAHQWPQGPSAVD 309
           GP+  + C   L   A+T+   G    F    Y R +          I+  WPQ P+ ++
Sbjct: 205 GPQTPKACDSKLTFDAITTIR-GEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLE 263

Query: 310 AAFSW--EEKLYLVQGTQVYVFLTKGGYTLVSGYPKRLEKEVGTPHGIILDSVDAAFICP 367
           AA+ +   +++   +G + +      G  ++ GYPK +    G P  +    +DAA    
Sbjct: 264 AAYEFADRDEVRFFKGNKYWAV---QGQNVLHGYPKDIYSSFGFPRTV--KHIDAALSEE 318

Query: 368 GSSRLHIMAGRRLWWLD 384
            + + +     + W  D
Sbjct: 319 NTGKTYFFVANKYWRYD 335


>gi|4505215 matrix metalloproteinase 1 isoform 1 preproprotein [Homo
           sapiens]
          Length = 469

 Score = 55.8 bits (133), Expect = 8e-08
 Identities = 48/183 (26%), Positives = 78/183 (42%), Gaps = 20/183 (10%)

Query: 44  PDVTERCSDGWSFDATTLDDNGTMLFFKGEFVWKSHKWDREL----ISERWKNFPSPVDA 99
           P   + C    +FDA T    G ++FFK  F  +++ +  E+    IS  W   P+ ++A
Sbjct: 272 PQTPKACDSKLTFDAITTI-RGEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLEA 330

Query: 100 AFR-QGHNSVFLIKGDKVWVYPPEKKEKGYPKLLQDEF--PGIPSPLDAAVECHRGECQA 156
           A+     + V   KG+K W    +    GYPK +   F  P     +DAA+     E   
Sbjct: 331 AYEFADRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSFGFPRTVKHIDAALS----EENT 386

Query: 157 EGVLFFQGDREWFWDLATGTMKE-------RSWPAVGNCSSALRWL-GRYYCFQGNQFLR 208
               FF  ++ W +D    +M           +P +G+   A+    G +Y F G +  +
Sbjct: 387 GKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYFFHGTRQYK 446

Query: 209 FDP 211
           FDP
Sbjct: 447 FDP 449



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 26/69 (37%), Positives = 33/69 (47%), Gaps = 3/69 (4%)

Query: 264 SALTSDNHGATYAFSGTHYWRLD---TSRDGWHSWPIAHQWPQGPSAVDAAFSWEEKLYL 320
           +AL+ +N G TY F    YWR D    S D  +   IAH +P     VDA F  +   Y 
Sbjct: 379 AALSEENTGKTYFFVANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVFMKDGFFYF 438

Query: 321 VQGTQVYVF 329
             GT+ Y F
Sbjct: 439 FHGTRQYKF 447



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 38/137 (27%), Positives = 58/137 (42%), Gaps = 26/137 (18%)

Query: 63  DNGTMLFFKGEFVWKS------HKWDRELISERWKNFPSPV---DAAFRQGHNS-VFLIK 112
           D   + FFKG   W        H + +++ S     FP  V   DAA  + +    +   
Sbjct: 336 DRDEVRFFKGNKYWAVQGQNVLHGYPKDIYSSF--GFPRTVKHIDAALSEENTGKTYFFV 393

Query: 113 GDKVWVYPPEKK--EKGYPKLLQDEFPGIPSPLDAAVECHRGECQAEGVL-FFQGDREWF 169
            +K W Y   K+  + GYPK++  +FPGI   +DA           +G   FF G R++ 
Sbjct: 394 ANKYWRYDEYKRSMDPGYPKMIAHDFPGIGHKVDAVF-------MKDGFFYFFHGTRQYK 446

Query: 170 WDLATGTM----KERSW 182
           +D  T  +    K  SW
Sbjct: 447 FDPKTKRILTLQKANSW 463



 Score = 34.7 bits (78), Expect = 0.19
 Identities = 30/137 (21%), Positives = 56/137 (40%), Gaps = 9/137 (6%)

Query: 251 GPEYMR-CSPHLVLSALTSDNHGATYAFSGTHYWRLDTSRDGWHSWPIAHQWPQGPSAVD 309
           GP+  + C   L   A+T+   G    F    Y R +          I+  WPQ P+ ++
Sbjct: 271 GPQTPKACDSKLTFDAITTIR-GEVMFFKDRFYMRTNPFYPEVELNFISVFWPQLPNGLE 329

Query: 310 AAFSW--EEKLYLVQGTQVYVFLTKGGYTLVSGYPKRLEKEVGTPHGIILDSVDAAFICP 367
           AA+ +   +++   +G + +      G  ++ GYPK +    G P  +    +DAA    
Sbjct: 330 AAYEFADRDEVRFFKGNKYWAV---QGQNVLHGYPKDIYSSFGFPRTV--KHIDAALSEE 384

Query: 368 GSSRLHIMAGRRLWWLD 384
            + + +     + W  D
Sbjct: 385 NTGKTYFFVANKYWRYD 401


>gi|189181724 proteoglycan 4 isoform D [Homo sapiens]
          Length = 1270

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 36/125 (28%), Positives = 57/125 (45%), Gaps = 8/125 (6%)

Query: 45   DVTERCSDGWSFDATTLDDNGTMLFFKGEFVWKSHKWD----RELISERWKNFPSPVDAA 100
            D T  C+ G   D  T   NGT++ F+G + W    +        I+E W   PSP+D  
Sbjct: 1007 DETNICN-GKPVDGLTTLRNGTLVAFRGHYFWMLSPFSPPSPARRITEVW-GIPSPIDTV 1064

Query: 101  FRQGH--NSVFLIKGDKVWVYPPEKKEKGYPKLLQDEFPGIPSPLDAAVECHRGECQAEG 158
            F + +     F  K  + W +  + K+ GYPK +   F G+   + AA+   + +   E 
Sbjct: 1065 FTRCNCEGKTFFFKDSQYWRFTNDIKDAGYPKPIFKGFGGLTGQIVAALSTAKYKNWPES 1124

Query: 159  VLFFQ 163
            V FF+
Sbjct: 1125 VYFFK 1129



 Score = 30.4 bits (67), Expect = 3.5
 Identities = 27/104 (25%), Positives = 44/104 (42%), Gaps = 7/104 (6%)

Query: 263  LSALTSDNHGATYAFSGTHYWRLDTSRDGWHSWPIAHQWPQGPSAVDAAF---SWEEKLY 319
            +  LT+  +G   AF G ++W L        +  I   W   PS +D  F   + E K +
Sbjct: 1017 VDGLTTLRNGTLVAFRGHYFWMLSPFSPPSPARRITEVWGI-PSPIDTVFTRCNCEGKTF 1075

Query: 320  LVQGTQVYVFLTKGGYTLVSGYPKRLEKEVGTPHGIILDSVDAA 363
              + +Q + F         +GYPK + K  G   G I+ ++  A
Sbjct: 1076 FFKDSQYWRFTND---IKDAGYPKPIFKGFGGLTGQIVAALSTA 1116


>gi|189181722 proteoglycan 4 isoform C [Homo sapiens]
          Length = 1311

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 36/125 (28%), Positives = 57/125 (45%), Gaps = 8/125 (6%)

Query: 45   DVTERCSDGWSFDATTLDDNGTMLFFKGEFVWKSHKWD----RELISERWKNFPSPVDAA 100
            D T  C+ G   D  T   NGT++ F+G + W    +        I+E W   PSP+D  
Sbjct: 1048 DETNICN-GKPVDGLTTLRNGTLVAFRGHYFWMLSPFSPPSPARRITEVW-GIPSPIDTV 1105

Query: 101  FRQGH--NSVFLIKGDKVWVYPPEKKEKGYPKLLQDEFPGIPSPLDAAVECHRGECQAEG 158
            F + +     F  K  + W +  + K+ GYPK +   F G+   + AA+   + +   E 
Sbjct: 1106 FTRCNCEGKTFFFKDSQYWRFTNDIKDAGYPKPIFKGFGGLTGQIVAALSTAKYKNWPES 1165

Query: 159  VLFFQ 163
            V FF+
Sbjct: 1166 VYFFK 1170



 Score = 30.4 bits (67), Expect = 3.5
 Identities = 27/104 (25%), Positives = 44/104 (42%), Gaps = 7/104 (6%)

Query: 263  LSALTSDNHGATYAFSGTHYWRLDTSRDGWHSWPIAHQWPQGPSAVDAAF---SWEEKLY 319
            +  LT+  +G   AF G ++W L        +  I   W   PS +D  F   + E K +
Sbjct: 1058 VDGLTTLRNGTLVAFRGHYFWMLSPFSPPSPARRITEVWGI-PSPIDTVFTRCNCEGKTF 1116

Query: 320  LVQGTQVYVFLTKGGYTLVSGYPKRLEKEVGTPHGIILDSVDAA 363
              + +Q + F         +GYPK + K  G   G I+ ++  A
Sbjct: 1117 FFKDSQYWRFTND---IKDAGYPKPIFKGFGGLTGQIVAALSTA 1157


>gi|189181720 proteoglycan 4 isoform B [Homo sapiens]
          Length = 1363

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 36/125 (28%), Positives = 57/125 (45%), Gaps = 8/125 (6%)

Query: 45   DVTERCSDGWSFDATTLDDNGTMLFFKGEFVWKSHKWD----RELISERWKNFPSPVDAA 100
            D T  C+ G   D  T   NGT++ F+G + W    +        I+E W   PSP+D  
Sbjct: 1100 DETNICN-GKPVDGLTTLRNGTLVAFRGHYFWMLSPFSPPSPARRITEVW-GIPSPIDTV 1157

Query: 101  FRQGH--NSVFLIKGDKVWVYPPEKKEKGYPKLLQDEFPGIPSPLDAAVECHRGECQAEG 158
            F + +     F  K  + W +  + K+ GYPK +   F G+   + AA+   + +   E 
Sbjct: 1158 FTRCNCEGKTFFFKDSQYWRFTNDIKDAGYPKPIFKGFGGLTGQIVAALSTAKYKNWPES 1217

Query: 159  VLFFQ 163
            V FF+
Sbjct: 1218 VYFFK 1222



 Score = 30.4 bits (67), Expect = 3.5
 Identities = 27/104 (25%), Positives = 44/104 (42%), Gaps = 7/104 (6%)

Query: 263  LSALTSDNHGATYAFSGTHYWRLDTSRDGWHSWPIAHQWPQGPSAVDAAF---SWEEKLY 319
            +  LT+  +G   AF G ++W L        +  I   W   PS +D  F   + E K +
Sbjct: 1110 VDGLTTLRNGTLVAFRGHYFWMLSPFSPPSPARRITEVWGI-PSPIDTVFTRCNCEGKTF 1168

Query: 320  LVQGTQVYVFLTKGGYTLVSGYPKRLEKEVGTPHGIILDSVDAA 363
              + +Q + F         +GYPK + K  G   G I+ ++  A
Sbjct: 1169 FFKDSQYWRFTND---IKDAGYPKPIFKGFGGLTGQIVAALSTA 1209


>gi|67190163 proteoglycan 4 isoform A [Homo sapiens]
          Length = 1404

 Score = 53.1 bits (126), Expect = 5e-07
 Identities = 36/125 (28%), Positives = 57/125 (45%), Gaps = 8/125 (6%)

Query: 45   DVTERCSDGWSFDATTLDDNGTMLFFKGEFVWKSHKWD----RELISERWKNFPSPVDAA 100
            D T  C+ G   D  T   NGT++ F+G + W    +        I+E W   PSP+D  
Sbjct: 1141 DETNICN-GKPVDGLTTLRNGTLVAFRGHYFWMLSPFSPPSPARRITEVW-GIPSPIDTV 1198

Query: 101  FRQGH--NSVFLIKGDKVWVYPPEKKEKGYPKLLQDEFPGIPSPLDAAVECHRGECQAEG 158
            F + +     F  K  + W +  + K+ GYPK +   F G+   + AA+   + +   E 
Sbjct: 1199 FTRCNCEGKTFFFKDSQYWRFTNDIKDAGYPKPIFKGFGGLTGQIVAALSTAKYKNWPES 1258

Query: 159  VLFFQ 163
            V FF+
Sbjct: 1259 VYFFK 1263



 Score = 30.4 bits (67), Expect = 3.5
 Identities = 27/104 (25%), Positives = 44/104 (42%), Gaps = 7/104 (6%)

Query: 263  LSALTSDNHGATYAFSGTHYWRLDTSRDGWHSWPIAHQWPQGPSAVDAAF---SWEEKLY 319
            +  LT+  +G   AF G ++W L        +  I   W   PS +D  F   + E K +
Sbjct: 1151 VDGLTTLRNGTLVAFRGHYFWMLSPFSPPSPARRITEVWGI-PSPIDTVFTRCNCEGKTF 1209

Query: 320  LVQGTQVYVFLTKGGYTLVSGYPKRLEKEVGTPHGIILDSVDAA 363
              + +Q + F         +GYPK + K  G   G I+ ++  A
Sbjct: 1210 FFKDSQYWRFTND---IKDAGYPKPIFKGFGGLTGQIVAALSTA 1250


>gi|45359865 matrix metalloproteinase 20 preproprotein [Homo
           sapiens]
          Length = 483

 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 38/133 (28%), Positives = 61/133 (45%), Gaps = 20/133 (15%)

Query: 63  DNGTMLFFKGEFVWKSHKWDRELISERWKNFPSP-----VDAA--FRQGHNSVFLIKGDK 115
           + GT  FFKG   W +  +  +       +F  P     +DAA   R+   ++F + GD+
Sbjct: 355 ERGTAYFFKGPHYWITRGFQMQGPPRTIYDFGFPRHVQQIDAAVYLREPQKTLFFV-GDE 413

Query: 116 VWVYPPEKK--EKGYPKLLQDEFPGIPSPLDAAVECHRGECQAEGVLFFQGDREWFWDL- 172
            + Y   K+  EK YPK  ++EF G+   +DAAVE +        + FF G + + +D  
Sbjct: 414 YYSYDERKRKMEKDYPKNTEEEFSGVNGQIDAAVELN------GYIYFFSGPKTYKYDTE 467

Query: 173 ---ATGTMKERSW 182
                  +K  SW
Sbjct: 468 KEDVVSVVKSSSW 480



 Score = 45.8 bits (107), Expect = 8e-05
 Identities = 47/189 (24%), Positives = 76/189 (40%), Gaps = 23/189 (12%)

Query: 44  PDVTERCSDGWSFDATTLDDNGTMLFFKGEFVWKSHKWDR-----ELISERWKNFPSPVD 98
           P + + C    SFDA T+     +L FK    W+     R       I+  +    S VD
Sbjct: 290 PSIPDLCDSSSSFDAVTMLGK-ELLLFKDRIFWRRQVHLRTGIRPSTITSSFPQLMSNVD 348

Query: 99  AAFRQG-HNSVFLIKGDKVWVYPPEKKEKGYPKLLQD-EFPGIPSPLDAAVECHRGECQA 156
           AA+      + +  KG   W+    + + G P+ + D  FP     +DAAV       + 
Sbjct: 349 AAYEVAERGTAYFFKGPHYWITRGFQMQ-GPPRTIYDFGFPRHVQQIDAAVYLR----EP 403

Query: 157 EGVLFFQGDREWFWDLATGTMKERSWP---------AVGNCSSALRWLGRYYCFQGNQFL 207
           +  LFF GD  + +D     M E+ +P           G   +A+   G  Y F G +  
Sbjct: 404 QKTLFFVGDEYYSYDERKRKM-EKDYPKNTEEEFSGVNGQIDAAVELNGYIYFFSGPKTY 462

Query: 208 RFDPVRGEV 216
           ++D  + +V
Sbjct: 463 KYDTEKEDV 471


>gi|189217853 matrix metalloproteinase 2 isoform b [Homo sapiens]
          Length = 610

 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 46/185 (24%), Positives = 73/185 (39%), Gaps = 24/185 (12%)

Query: 44  PDVTERCSDGWSFDATTLDDNGTMLFFKGEFVWKS-----HKWDRELISERWKNFPSPVD 98
           P   E C     FD       G + FFK  F+W++           L++  W   P  +D
Sbjct: 413 PVTPEICKQDIVFDGIA-QIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKID 471

Query: 99  AAFR--QGHNSVFLIKGDKVWVYPPEKKEKGYPKLLQD-EFPGIPSPLDAAVECHRGECQ 155
           A +   Q   +VF   G++ W+Y     E+GYPK L     P     +DAA    +    
Sbjct: 472 AVYEAPQEEKAVF-FAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKN--- 527

Query: 156 AEGVLFFQGDREWFWDLATGTMK-------ERSWPAVGNCSSA---LRWLGRYYCFQGNQ 205
            +    F GD+ W ++     M          +W A+ +   A   L+  G  Y F+G  
Sbjct: 528 -KKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAY 586

Query: 206 FLRFD 210
           +L+ +
Sbjct: 587 YLKLE 591



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 37/143 (25%), Positives = 61/143 (42%), Gaps = 21/143 (14%)

Query: 103 QGHNSVFLIKGDKVW-VYPPEKKEKGYPKLLQDEFPGIPSPLDAAVECHRGECQAEGVLF 161
           Q    +F  K   +W    P  K  G P L+   +P +P  +DA  E      Q E  +F
Sbjct: 430 QIRGEIFFFKDRFIWRTVTPRDKPMG-PLLVATFWPELPEKIDAVYEAP----QEEKAVF 484

Query: 162 FQGDREWFWDLATGTMKERSWPA----------VGNCSSALRWLG--RYYCFQGNQFLRF 209
           F G+  W +  +T    ER +P           V    +A  W    + Y F G++F R+
Sbjct: 485 FAGNEYWIYSAST---LERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRY 541

Query: 210 DPVRGEVPPRYPRDVRDYFMPCP 232
           + V+ ++ P +P+ + D +   P
Sbjct: 542 NEVKKKMDPGFPKLIADAWNAIP 564



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 37/128 (28%), Positives = 55/128 (42%), Gaps = 10/128 (7%)

Query: 257 CSPHLVLSALTSDNHGATYAFSGTHYWRLDTSRDG-WHSWPIAHQWPQGPSAVDAAFS-- 313
           C   +V   + +   G  + F     WR  T RD       +A  WP+ P  +DA +   
Sbjct: 419 CKQDIVFDGI-AQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAP 477

Query: 314 WEEKLYLVQGTQVYVFLTKGGYTLVSGYPKRLEKEVGTPHGIILDSVDAAFICPGSSRLH 373
            EEK     G + +++      TL  GYPK L   +G P  +    VDAAF    + + +
Sbjct: 478 QEEKAVFFAGNEYWIYSAS---TLERGYPKPLTS-LGLPPDV--QRVDAAFNWSKNKKTY 531

Query: 374 IMAGRRLW 381
           I AG + W
Sbjct: 532 IFAGDKFW 539


>gi|11342666 matrix metalloproteinase 2 isoform a preproprotein
           [Homo sapiens]
          Length = 660

 Score = 49.3 bits (116), Expect = 7e-06
 Identities = 46/185 (24%), Positives = 73/185 (39%), Gaps = 24/185 (12%)

Query: 44  PDVTERCSDGWSFDATTLDDNGTMLFFKGEFVWKS-----HKWDRELISERWKNFPSPVD 98
           P   E C     FD       G + FFK  F+W++           L++  W   P  +D
Sbjct: 463 PVTPEICKQDIVFDGIA-QIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKID 521

Query: 99  AAFR--QGHNSVFLIKGDKVWVYPPEKKEKGYPKLLQD-EFPGIPSPLDAAVECHRGECQ 155
           A +   Q   +VF   G++ W+Y     E+GYPK L     P     +DAA    +    
Sbjct: 522 AVYEAPQEEKAVF-FAGNEYWIYSASTLERGYPKPLTSLGLPPDVQRVDAAFNWSKN--- 577

Query: 156 AEGVLFFQGDREWFWDLATGTMK-------ERSWPAVGNCSSA---LRWLGRYYCFQGNQ 205
            +    F GD+ W ++     M          +W A+ +   A   L+  G  Y F+G  
Sbjct: 578 -KKTYIFAGDKFWRYNEVKKKMDPGFPKLIADAWNAIPDNLDAVVDLQGGGHSYFFKGAY 636

Query: 206 FLRFD 210
           +L+ +
Sbjct: 637 YLKLE 641



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 37/143 (25%), Positives = 61/143 (42%), Gaps = 21/143 (14%)

Query: 103 QGHNSVFLIKGDKVW-VYPPEKKEKGYPKLLQDEFPGIPSPLDAAVECHRGECQAEGVLF 161
           Q    +F  K   +W    P  K  G P L+   +P +P  +DA  E      Q E  +F
Sbjct: 480 QIRGEIFFFKDRFIWRTVTPRDKPMG-PLLVATFWPELPEKIDAVYEAP----QEEKAVF 534

Query: 162 FQGDREWFWDLATGTMKERSWPA----------VGNCSSALRWLG--RYYCFQGNQFLRF 209
           F G+  W +  +T    ER +P           V    +A  W    + Y F G++F R+
Sbjct: 535 FAGNEYWIYSAST---LERGYPKPLTSLGLPPDVQRVDAAFNWSKNKKTYIFAGDKFWRY 591

Query: 210 DPVRGEVPPRYPRDVRDYFMPCP 232
           + V+ ++ P +P+ + D +   P
Sbjct: 592 NEVKKKMDPGFPKLIADAWNAIP 614



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 37/128 (28%), Positives = 55/128 (42%), Gaps = 10/128 (7%)

Query: 257 CSPHLVLSALTSDNHGATYAFSGTHYWRLDTSRDG-WHSWPIAHQWPQGPSAVDAAFS-- 313
           C   +V   + +   G  + F     WR  T RD       +A  WP+ P  +DA +   
Sbjct: 469 CKQDIVFDGI-AQIRGEIFFFKDRFIWRTVTPRDKPMGPLLVATFWPELPEKIDAVYEAP 527

Query: 314 WEEKLYLVQGTQVYVFLTKGGYTLVSGYPKRLEKEVGTPHGIILDSVDAAFICPGSSRLH 373
            EEK     G + +++      TL  GYPK L   +G P  +    VDAAF    + + +
Sbjct: 528 QEEKAVFFAGNEYWIYSAS---TLERGYPKPLTS-LGLPPDV--QRVDAAFNWSKNKKTY 581

Query: 374 IMAGRRLW 381
           I AG + W
Sbjct: 582 IFAGDKFW 589


>gi|11968059 matrix metalloproteinase 25 preproprotein [Homo
           sapiens]
          Length = 562

 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 73/294 (24%), Positives = 103/294 (35%), Gaps = 94/294 (31%)

Query: 27  PPTSAHGNVAEGETKPDPDVTERCSDGWSFDATTLDDNGTMLFFKGEFVWKSHKWDRELI 86
           PP     +     + P PD   RC    +FDA   +  G   FFKG + W+      +L+
Sbjct: 297 PPPQPPASPTHSPSFPIPD---RCEG--NFDAIA-NIRGETFFFKGPWFWRLQP-SGQLV 349

Query: 87  SER-------WKNFPSPV---DAAF-RQGHNSVFLIKGDKVWVYPPEKKEKGYPKLLQDE 135
           S R       W+  P+ V    AA+ R     + L  G + WV+   + E G   L +  
Sbjct: 350 SPRPARLHRFWEGLPAQVRVVQAAYARHRDGRILLFSGPQFWVFQDRQLEGGARPLTE-- 407

Query: 136 FPGIPSPLDAAVECHRGECQAEGVLFFQGDREWFWDLATGTMKERSWPAVGNCSSALRWL 195
             G+P           GE + + V                     SWP  G         
Sbjct: 408 -LGLPP----------GE-EVDAVF--------------------SWPQNG--------- 426

Query: 196 GRYYCFQGNQFLRFDPVRGEVPPRYPRDVRDYFMPCPGRGHGHRNGTGHGNSTHHGPEYM 255
            + Y  +G Q+ R+D       P YPRD+  +    P                       
Sbjct: 427 -KTYLVRGRQYWRYDEAAARPDPGYPRDLSLWEGAPP----------------------- 462

Query: 256 RCSPHLVLSALTSDNHGATYAFSGTHYWRLDTSRDGWHSWPIAHQWPQGPSAVD 309
             SP  V    T  N G TY F G HYWR    ++   + P A Q P GP+ +D
Sbjct: 463 --SPDDV----TVSNAGDTYFFKGAHYWRF--PKNSIKTEPDAPQ-PMGPNWLD 507



 Score = 38.5 bits (88), Expect = 0.013
 Identities = 35/120 (29%), Positives = 56/120 (46%), Gaps = 15/120 (12%)

Query: 272 GATYAFSGTHYWRLDTSRDGWHSWPIA-HQWPQGPSA----VDAAFSWEE--KLYLVQGT 324
           G T+ F G  +WRL  S       P   H++ +G  A    V AA++     ++ L  G 
Sbjct: 329 GETFFFKGPWFWRLQPSGQLVSPRPARLHRFWEGLPAQVRVVQAAYARHRDGRILLFSGP 388

Query: 325 QVYVFLTKGGYTLVSGYPKRLEKEVGTPHGIILDSVDAAFICPGSSRLHIMAGRRLWWLD 384
           Q +VF  +     + G  + L  E+G P G   + VDA F  P + + +++ GR+ W  D
Sbjct: 389 QFWVFQDRQ----LEGGARPLT-ELGLPPG---EEVDAVFSWPQNGKTYLVRGRQYWRYD 440


>gi|74272287 matrix metalloproteinase 9 preproprotein [Homo sapiens]
          Length = 707

 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 37/117 (31%), Positives = 58/117 (49%), Gaps = 13/117 (11%)

Query: 275 YAFSGTHYWRLDTSRDGWHSWP--IAHQWPQGPSAVDAAFS--WEEKLYLVQGTQVYVFL 330
           Y F    YWR    R      P  IA +WP  P  +D+ F     +KL+   G QV+V+ 
Sbjct: 532 YLFKDGKYWRFSEGRGSRPQGPFLIADKWPALPRKLDSVFEERLSKKLFFFSGRQVWVYT 591

Query: 331 TKGGYTLVSGYPKRLEKEVGTPHGIILDSVDAAFICPGSSRLHIMAGRRLWWLDLKS 387
              G +++   P+RL+K +G   G  +  V  A +  G  ++ + +GRRLW  D+K+
Sbjct: 592 ---GASVLG--PRRLDK-LGL--GADVAQVTGA-LRSGRGKMLLFSGRRLWRFDVKA 639



 Score = 40.4 bits (93), Expect = 0.003
 Identities = 36/134 (26%), Positives = 56/134 (41%), Gaps = 11/134 (8%)

Query: 106 NSVFLIKGDKVWVYPPEKKEKGY-PKLLQDEFPGIPSPLDAAVECHRGECQAEGVLFFQG 164
           N ++L K  K W +   +  +   P L+ D++P +P  LD+  E    E  ++ + FF G
Sbjct: 529 NQLYLFKDGKYWRFSEGRGSRPQGPFLIADKWPALPRKLDSVFE----ERLSKKLFFFSG 584

Query: 165 DREWFWDLATGTMKERS-----WPAVGNCSSALR-WLGRYYCFQGNQFLRFDPVRGEVPP 218
            + W +  A+     R         V   + ALR   G+   F G +  RFD     V P
Sbjct: 585 RQVWVYTGASVLGPRRLDKLGLGADVAQVTGALRSGRGKMLLFSGRRLWRFDVKAQMVDP 644

Query: 219 RYPRDVRDYFMPCP 232
           R   +V   F   P
Sbjct: 645 RSASEVDRMFPGVP 658


>gi|22218341 matrix metalloproteinase 21 preproprotein [Homo
           sapiens]
          Length = 569

 Score = 43.1 bits (100), Expect = 5e-04
 Identities = 42/190 (22%), Positives = 64/190 (33%), Gaps = 72/190 (37%)

Query: 109 FLIKGDKVWVYPPEKKE--------KGYPKLLQDEFPGIPSPLDAAVECHRGECQAEGVL 160
           +  +G++ W Y  +K +        K YPKL+ + FPGIPSPLD A              
Sbjct: 409 YFFQGNQYWRYDSDKDQALTEDEQGKSYPKLISEGFPGIPSPLDTA-------------- 454

Query: 161 FFQGDREWFWDLATGTMKERSWPAVGNCSSALRWLGRYYCFQGNQFLRFDPVRGEVPPRY 220
                   F+D                     R     Y F+ +    FD  R  V   Y
Sbjct: 455 --------FYD---------------------RRQKLIYFFKESLVFAFDVNRNRVLNSY 485

Query: 221 PRDVRDYFMPCPGRGHGHRNGTGHGNSTHHGPEYMRCSPHLVLSALTSDNHGATYAFSGT 280
           P+ + + F     + H  RN                     + SA  S  + + + F G 
Sbjct: 486 PKRITEVFPAVIPQNHPFRN---------------------IDSAYYSYAYNSIFFFKGN 524

Query: 281 HYWRLDTSRD 290
            YW++   +D
Sbjct: 525 AYWKVVNDKD 534



 Score = 37.0 bits (84), Expect = 0.038
 Identities = 30/120 (25%), Positives = 51/120 (42%), Gaps = 14/120 (11%)

Query: 275 YAFSGTHYWRLDTSRD-------GWHSWP--IAHQWPQGPSAVDAAF--SWEEKLYLVQG 323
           Y F G  YWR D+ +D          S+P  I+  +P  PS +D AF    ++ +Y  + 
Sbjct: 409 YFFQGNQYWRYDSDKDQALTEDEQGKSYPKLISEGFPGIPSPLDTAFYDRRQKLIYFFKE 468

Query: 324 TQVYVFLTKGGYTLVSGYPKRLEK--EVGTPHGIILDSVDAAFICPGSSRLHIMAGRRLW 381
           + V+ F       L + YPKR+ +      P      ++D+A+     + +    G   W
Sbjct: 469 SLVFAFDVNRNRVL-NSYPKRITEVFPAVIPQNHPFRNIDSAYYSYAYNSIFFFKGNAYW 527



 Score = 32.3 bits (72), Expect = 0.93
 Identities = 25/94 (26%), Positives = 41/94 (43%), Gaps = 13/94 (13%)

Query: 84  ELISERWKNFPSPVDAAFRQGHNS-VFLIKGDKVWVYPPEKKE--KGYPKLLQDEFPG-I 139
           +LISE +   PSP+D AF       ++  K   V+ +   +      YPK + + FP  I
Sbjct: 438 KLISEGFPGIPSPLDTAFYDRRQKLIYFFKESLVFAFDVNRNRVLNSYPKRITEVFPAVI 497

Query: 140 PS-----PLDAAVECHRGECQAEGVLFFQGDREW 168
           P       +D+A   +        + FF+G+  W
Sbjct: 498 PQNHPFRNIDSAYYSY----AYNSIFFFKGNAYW 527


>gi|13236530 matrix metalloproteinase 28 isoform 1 preproprotein
           [Homo sapiens]
          Length = 520

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 28/98 (28%), Positives = 43/98 (43%), Gaps = 7/98 (7%)

Query: 55  SFDATTLDDNGTMLFFKGEFVWK----SHKWDRELISERWKNFPSPVD-AAFRQGHNSVF 109
           SFDA T+D    +  FKG   W+     +  +   + ERW   P  ++ AA        +
Sbjct: 327 SFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPRPLQERWVGLPPNIEAAAVSLNDGDFY 386

Query: 110 LIKGDKVWVYPPEKKEKGYPKLLQDEFPGIPSPLDAAV 147
             KG + W +   K   G P+L +    G+P   DAA+
Sbjct: 387 FFKGGRCWRFRGPKPVWGLPQLCR--AGGLPRHPDAAL 422



 Score = 40.0 bits (92), Expect = 0.004
 Identities = 46/199 (23%), Positives = 67/199 (33%), Gaps = 62/199 (31%)

Query: 251 GPEYMRCSPHLVLSALTSDNHGATYAFSGTHYWRLDTSRDGWHSWPIAHQWPQGPSAVDA 310
           GP+Y     H    A+T D     Y F G+H+W +    +     P+  +W   P  ++A
Sbjct: 320 GPKYC----HSSFDAITVDRQQQLYIFKGSHFWEVAADGNVSEPRPLQERWVGLPPNIEA 375

Query: 311 A-----------------------------------------------FSWEEKLYLVQG 323
           A                                               F    +L L +G
Sbjct: 376 AAVSLNDGDFYFFKGGRCWRFRGPKPVWGLPQLCRAGGLPRHPDAALFFPPLRRLILFKG 435

Query: 324 TQVYVFLTKGGYTLVSGYPKRLEKEVGTPHGIILDSVDAAFICPGSSRLHIMAGRRLWWL 383
            + YV L +GG  +   YP+ L+   G P     + V  A   P  S +      R W L
Sbjct: 436 ARYYV-LARGGLQVEPYYPRSLQDWGGIP-----EEVSGALPRPDGS-IIFFRDDRYWRL 488

Query: 384 D---LKSGAQATW-TELPW 398
           D   L++     W TELPW
Sbjct: 489 DQAKLQATTSGRWATELPW 507


>gi|72534732 dehydrogenase/reductase (SDR family) member 12 isoform
           1 [Homo sapiens]
          Length = 271

 Score = 41.2 bits (95), Expect = 0.002
 Identities = 34/147 (23%), Positives = 53/147 (36%), Gaps = 15/147 (10%)

Query: 39  ETKPDPDVTERCSDGWSFDATTLDD-NGTMLFFKGEFVWKSHKWDRELISERWKNFPSPV 97
           E + DP V    S G        +D       F G  V+  +K  + +++ERW       
Sbjct: 114 EKEHDPRVITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWA------ 167

Query: 98  DAAFRQGHNSVFLIKGDKVWVYPPEKKEKGYPKLLQDEFPGIPSPLDAAVECHRGECQAE 157
                QGH ++        W   P++ E+   K++ +     P P    +  H G+CQ +
Sbjct: 168 -----QGHPAIHFSSMHPGWADTPDRNEQELRKVVGEAQTASPLPRFLEIMMHEGKCQPQ 222

Query: 158 GVLFFQGDREWFWDLATGTMKE-RSWP 183
           G      D E  W    G       WP
Sbjct: 223 G--HSSNDLEACWSSGGGEQNSLPDWP 247


>gi|5729720 actin-like 7A [Homo sapiens]
          Length = 435

 Score = 32.7 bits (73), Expect = 0.71
 Identities = 19/55 (34%), Positives = 28/55 (50%), Gaps = 6/55 (10%)

Query: 333 GGYTLVSGYPKRLEKEVG------TPHGIILDSVDAAFICPGSSRLHIMAGRRLW 381
           GG T++SG+P RL+KE+       TP   +L   D+A    GS    +   + LW
Sbjct: 362 GGSTMLSGFPNRLQKELSSMCPNDTPQVNVLPERDSAVWTGGSILASLQGFQPLW 416


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.320    0.138    0.471 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,764,509
Number of Sequences: 37866
Number of extensions: 1215837
Number of successful extensions: 2742
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 29
Number of HSP's successfully gapped in prelim test: 9
Number of HSP's that attempted gapping in prelim test: 2548
Number of HSP's gapped (non-prelim): 122
length of query: 462
length of database: 18,247,518
effective HSP length: 106
effective length of query: 356
effective length of database: 14,233,722
effective search space: 5067205032
effective search space used: 5067205032
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.