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Search of human proteins with 113205085
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|113205085 leucine rich repeat containing 31 [Homo sapiens]
(552 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|113205085 leucine rich repeat containing 31 [Homo sapiens] 1085 0.0
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 110 4e-24
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens] 110 4e-24
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens] 110 4e-24
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens] 110 4e-24
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens] 110 4e-24
gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens] 110 4e-24
gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens] 110 4e-24
gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens] 110 4e-24
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 76 9e-14
gi|116268109 nucleotide-binding oligomerization domains 27 [Homo... 75 2e-13
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 67 3e-11
gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Ho... 64 4e-10
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 63 6e-10
gi|40788015 caspase recruitment domain protein 12 [Homo sapiens] 61 2e-09
gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo... 60 7e-09
gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Hom... 60 7e-09
gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Hom... 60 7e-09
gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens] 59 9e-09
gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Hom... 59 2e-08
gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Hom... 59 2e-08
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 56 8e-08
gi|4506411 Ran GTPase activating protein 1 [Homo sapiens] 56 1e-07
gi|4503743 flightless I homolog [Homo sapiens] 55 2e-07
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 54 4e-07
gi|187937176 NACHT, leucine rich repeat and PYD containing 7 iso... 54 4e-07
gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isof... 54 4e-07
gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens] 52 1e-06
gi|118918429 NOD3 protein [Homo sapiens] 52 2e-06
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 51 3e-06
>gi|113205085 leucine rich repeat containing 31 [Homo sapiens]
Length = 552
Score = 1085 bits (2805), Expect = 0.0
Identities = 552/552 (100%), Positives = 552/552 (100%)
Query: 1 MSQTRKKTSSEGETKPQTSTVNKFLRGSNAESRKEDNDLKTSDSQPSDWIQKTATSETAK 60
MSQTRKKTSSEGETKPQTSTVNKFLRGSNAESRKEDNDLKTSDSQPSDWIQKTATSETAK
Sbjct: 1 MSQTRKKTSSEGETKPQTSTVNKFLRGSNAESRKEDNDLKTSDSQPSDWIQKTATSETAK 60
Query: 61 PLSSEMEWRSSMEKNEHFLQKLGKKAVNKCLDLNNCGLTTADMKEMVALLPFLPDLEELD 120
PLSSEMEWRSSMEKNEHFLQKLGKKAVNKCLDLNNCGLTTADMKEMVALLPFLPDLEELD
Sbjct: 61 PLSSEMEWRSSMEKNEHFLQKLGKKAVNKCLDLNNCGLTTADMKEMVALLPFLPDLEELD 120
Query: 121 ISWNGFVGGTLLSITQQMHLVSKLKILRLGSCRLTTDDVQALGEAFEMIPELEELNLSWN 180
ISWNGFVGGTLLSITQQMHLVSKLKILRLGSCRLTTDDVQALGEAFEMIPELEELNLSWN
Sbjct: 121 ISWNGFVGGTLLSITQQMHLVSKLKILRLGSCRLTTDDVQALGEAFEMIPELEELNLSWN 180
Query: 181 SKVGGNLPLILQKFQKGSKIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLDLSINRDIV 240
SKVGGNLPLILQKFQKGSKIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLDLSINRDIV
Sbjct: 181 SKVGGNLPLILQKFQKGSKIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLDLSINRDIV 240
Query: 241 GSLNSIAQGLKSTSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFE 300
GSLNSIAQGLKSTSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFE
Sbjct: 241 GSLNSIAQGLKSTSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFE 300
Query: 301 DSPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLS 360
DSPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLS
Sbjct: 301 DSPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLS 360
Query: 361 RLRFLPALKSLVINNCALESETFTALAEASVHLSALEVFNLSWNKCVGGNLKLLLETLKL 420
RLRFLPALKSLVINNCALESETFTALAEASVHLSALEVFNLSWNKCVGGNLKLLLETLKL
Sbjct: 361 RLRFLPALKSLVINNCALESETFTALAEASVHLSALEVFNLSWNKCVGGNLKLLLETLKL 420
Query: 421 SMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLSYNDSICDAGWTMFCQNVRFL 480
SMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLSYNDSICDAGWTMFCQNVRFL
Sbjct: 421 SMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLSYNDSICDAGWTMFCQNVRFL 480
Query: 481 KELIELDISLRPSNFRDCGQWFRHLLYAVTKLPQITEIGMKRWILPASQEEELECFDQDK 540
KELIELDISLRPSNFRDCGQWFRHLLYAVTKLPQITEIGMKRWILPASQEEELECFDQDK
Sbjct: 481 KELIELDISLRPSNFRDCGQWFRHLLYAVTKLPQITEIGMKRWILPASQEEELECFDQDK 540
Query: 541 KRSIHFDHGGFQ 552
KRSIHFDHGGFQ
Sbjct: 541 KRSIHFDHGGFQ 552
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 110 bits (274), Expect = 4e-24
Identities = 114/408 (27%), Positives = 188/408 (46%), Gaps = 17/408 (4%)
Query: 93 LNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVGGTLLSITQQMHLVS-KLKILRLGS 151
L++CGLT A K++ + L P L EL++ N + + Q + S K++ L L +
Sbjct: 35 LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQN 94
Query: 152 CRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQ-KFQKGSKIQMIELVDCSL 210
C LT L +P L+EL+LS N L L+ + +++ ++L CSL
Sbjct: 95 CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSL 154
Query: 211 TSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLK-STSNLKVLKLHSCGLSQK 269
++ L +L + L +S N + + QGLK S L+ LKL SCG++
Sbjct: 155 SAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD 214
Query: 270 SVKILDAAFRYLGELRKLDLSCNKDLG--GGFEDSPAQLVMLKHLQVLDLHQCSLTADDV 327
+ + L LR+L L NK LG G E P L L+ L + +C +TA
Sbjct: 215 NCRDLCGIVASKASLRELALGSNK-LGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGC 273
Query: 328 MSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLRFLPA--LKSLVINNCALESETFTA 385
L +V+ +L+EL L+ N ++G LL P L+SL + +C+ + +
Sbjct: 274 GDLCRVLRAKESLKELSLAGN-ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSH 332
Query: 386 LAEASVHLSALEVFNLSWNKCVGGNLKLLLETLKLSMS-LQVLRLSSCSLVTEDVALLAS 444
+ L +S N+ ++ L + L S L+VL L+ C + + LA+
Sbjct: 333 FSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAA 392
Query: 445 VIQTGHLAKLQKLDLSYNDSICDAGWTMFCQNVR----FLKELIELDI 488
+ H L++LDLS N+ + DAG ++VR L++L+ DI
Sbjct: 393 TLLANH--SLRELDLS-NNCLGDAGILQLVESVRQPGCLLEQLVLYDI 437
Score = 96.7 bits (239), Expect = 5e-20
Identities = 103/374 (27%), Positives = 165/374 (44%), Gaps = 23/374 (6%)
Query: 115 DLEELDISWNGFVGGTLLSITQQMHLVSKLKILRLGSCRLTTDDVQALGEAFEMIPELEE 174
D++ LDI + + L+ + +++RL C LT + + A + P L E
Sbjct: 4 DIQSLDIQCEELSDARWAEL---LPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
Query: 175 LNLSWNSKVGGNLPLILQKFQKGS-KIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLDL 233
LNL N + +LQ Q S KIQ + L +C LT L L L +L+ L L
Sbjct: 61 LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
Query: 234 SINRDIVGSLNSIAQGLKSTS-NLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCN 292
S N L + +GL L+ L+L C LS S + L + R + ++L +S N
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
Query: 293 -------KDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDL 345
+ L G +DSP QL LK L C +T+D+ L ++ ++L+EL L
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALK------LESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 346 SANKKMGSSSENLLSRLRFLPA-LKSLVINNCALESETFTALAEASVHLSALEVFNLSWN 404
+NK L L + L++L I C + ++ L +L+ +L+ N
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 405 KCVGGNLKLLLET-LKLSMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLSYND 463
+ +LL ET L+ L+ L + SCS + +SV+ L +L +S N+
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRF--LLELQIS-NN 351
Query: 464 SICDAGWTMFCQNV 477
+ DAG CQ +
Sbjct: 352 RLEDAGVRELCQGL 365
Score = 67.4 bits (163), Expect = 3e-11
Identities = 86/329 (26%), Positives = 147/329 (44%), Gaps = 18/329 (5%)
Query: 91 LDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVG--GTLLSITQQMHLVSKLKILR 148
L L NC LT A + + L LP L+EL +S N +G G L + +L+ L+
Sbjct: 90 LSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN-LLGDAGLQLLCEGLLDPQCRLEKLQ 148
Query: 149 LGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKG-SKIQMIELVD 207
L C L+ + L P+ +EL +S N + ++ Q + +++ ++L
Sbjct: 149 LEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLES 208
Query: 208 CSLTSEDGTFLGQLLPMLQSLEVLDLSINR-DIVGSLNSIAQGLKSTSNLKVLKLHSCGL 266
C +TS++ L ++ SL L L N+ VG L +S L+ L + CG+
Sbjct: 209 CGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGI 268
Query: 267 SQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLV---MLK---HLQVLDLHQC 320
+ K L R L++L L+ N +LG D A+L+ +L+ L+ L + C
Sbjct: 269 TAKGCGDLCRVLRAKESLKELSLAGN-ELG----DEGARLLCETLLEPGCQLESLWVKSC 323
Query: 321 SLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRL-RFLPALKSLVINNCALE 379
S TA + V+ L EL +S N+ + L L + L+ L + +C +
Sbjct: 324 SFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVS 383
Query: 380 SETFTALAEASVHLSALEVFNLSWNKCVG 408
+ ++LA + +L +LS N C+G
Sbjct: 384 DSSCSSLAATLLANHSLRELDLS-NNCLG 411
>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 110 bits (274), Expect = 4e-24
Identities = 114/408 (27%), Positives = 188/408 (46%), Gaps = 17/408 (4%)
Query: 93 LNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVGGTLLSITQQMHLVS-KLKILRLGS 151
L++CGLT A K++ + L P L EL++ N + + Q + S K++ L L +
Sbjct: 35 LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQN 94
Query: 152 CRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQ-KFQKGSKIQMIELVDCSL 210
C LT L +P L+EL+LS N L L+ + +++ ++L CSL
Sbjct: 95 CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSL 154
Query: 211 TSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLK-STSNLKVLKLHSCGLSQK 269
++ L +L + L +S N + + QGLK S L+ LKL SCG++
Sbjct: 155 SAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD 214
Query: 270 SVKILDAAFRYLGELRKLDLSCNKDLG--GGFEDSPAQLVMLKHLQVLDLHQCSLTADDV 327
+ + L LR+L L NK LG G E P L L+ L + +C +TA
Sbjct: 215 NCRDLCGIVASKASLRELALGSNK-LGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGC 273
Query: 328 MSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLRFLPA--LKSLVINNCALESETFTA 385
L +V+ +L+EL L+ N ++G LL P L+SL + +C+ + +
Sbjct: 274 GDLCRVLRAKESLKELSLAGN-ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSH 332
Query: 386 LAEASVHLSALEVFNLSWNKCVGGNLKLLLETLKLSMS-LQVLRLSSCSLVTEDVALLAS 444
+ L +S N+ ++ L + L S L+VL L+ C + + LA+
Sbjct: 333 FSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAA 392
Query: 445 VIQTGHLAKLQKLDLSYNDSICDAGWTMFCQNVR----FLKELIELDI 488
+ H L++LDLS N+ + DAG ++VR L++L+ DI
Sbjct: 393 TLLANH--SLRELDLS-NNCLGDAGILQLVESVRQPGCLLEQLVLYDI 437
Score = 96.7 bits (239), Expect = 5e-20
Identities = 103/374 (27%), Positives = 165/374 (44%), Gaps = 23/374 (6%)
Query: 115 DLEELDISWNGFVGGTLLSITQQMHLVSKLKILRLGSCRLTTDDVQALGEAFEMIPELEE 174
D++ LDI + + L+ + +++RL C LT + + A + P L E
Sbjct: 4 DIQSLDIQCEELSDARWAEL---LPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
Query: 175 LNLSWNSKVGGNLPLILQKFQKGS-KIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLDL 233
LNL N + +LQ Q S KIQ + L +C LT L L L +L+ L L
Sbjct: 61 LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
Query: 234 SINRDIVGSLNSIAQGLKSTS-NLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCN 292
S N L + +GL L+ L+L C LS S + L + R + ++L +S N
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
Query: 293 -------KDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDL 345
+ L G +DSP QL LK L C +T+D+ L ++ ++L+EL L
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALK------LESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 346 SANKKMGSSSENLLSRLRFLPA-LKSLVINNCALESETFTALAEASVHLSALEVFNLSWN 404
+NK L L + L++L I C + ++ L +L+ +L+ N
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 405 KCVGGNLKLLLET-LKLSMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLSYND 463
+ +LL ET L+ L+ L + SCS + +SV+ L +L +S N+
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRF--LLELQIS-NN 351
Query: 464 SICDAGWTMFCQNV 477
+ DAG CQ +
Sbjct: 352 RLEDAGVRELCQGL 365
Score = 67.4 bits (163), Expect = 3e-11
Identities = 86/329 (26%), Positives = 147/329 (44%), Gaps = 18/329 (5%)
Query: 91 LDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVG--GTLLSITQQMHLVSKLKILR 148
L L NC LT A + + L LP L+EL +S N +G G L + +L+ L+
Sbjct: 90 LSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN-LLGDAGLQLLCEGLLDPQCRLEKLQ 148
Query: 149 LGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKG-SKIQMIELVD 207
L C L+ + L P+ +EL +S N + ++ Q + +++ ++L
Sbjct: 149 LEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLES 208
Query: 208 CSLTSEDGTFLGQLLPMLQSLEVLDLSINR-DIVGSLNSIAQGLKSTSNLKVLKLHSCGL 266
C +TS++ L ++ SL L L N+ VG L +S L+ L + CG+
Sbjct: 209 CGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGI 268
Query: 267 SQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLV---MLK---HLQVLDLHQC 320
+ K L R L++L L+ N +LG D A+L+ +L+ L+ L + C
Sbjct: 269 TAKGCGDLCRVLRAKESLKELSLAGN-ELG----DEGARLLCETLLEPGCQLESLWVKSC 323
Query: 321 SLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRL-RFLPALKSLVINNCALE 379
S TA + V+ L EL +S N+ + L L + L+ L + +C +
Sbjct: 324 SFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVS 383
Query: 380 SETFTALAEASVHLSALEVFNLSWNKCVG 408
+ ++LA + +L +LS N C+G
Sbjct: 384 DSSCSSLAATLLANHSLRELDLS-NNCLG 411
>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 110 bits (274), Expect = 4e-24
Identities = 114/408 (27%), Positives = 188/408 (46%), Gaps = 17/408 (4%)
Query: 93 LNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVGGTLLSITQQMHLVS-KLKILRLGS 151
L++CGLT A K++ + L P L EL++ N + + Q + S K++ L L +
Sbjct: 35 LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQN 94
Query: 152 CRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQ-KFQKGSKIQMIELVDCSL 210
C LT L +P L+EL+LS N L L+ + +++ ++L CSL
Sbjct: 95 CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSL 154
Query: 211 TSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLK-STSNLKVLKLHSCGLSQK 269
++ L +L + L +S N + + QGLK S L+ LKL SCG++
Sbjct: 155 SAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD 214
Query: 270 SVKILDAAFRYLGELRKLDLSCNKDLG--GGFEDSPAQLVMLKHLQVLDLHQCSLTADDV 327
+ + L LR+L L NK LG G E P L L+ L + +C +TA
Sbjct: 215 NCRDLCGIVASKASLRELALGSNK-LGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGC 273
Query: 328 MSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLRFLPA--LKSLVINNCALESETFTA 385
L +V+ +L+EL L+ N ++G LL P L+SL + +C+ + +
Sbjct: 274 GDLCRVLRAKESLKELSLAGN-ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSH 332
Query: 386 LAEASVHLSALEVFNLSWNKCVGGNLKLLLETLKLSMS-LQVLRLSSCSLVTEDVALLAS 444
+ L +S N+ ++ L + L S L+VL L+ C + + LA+
Sbjct: 333 FSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAA 392
Query: 445 VIQTGHLAKLQKLDLSYNDSICDAGWTMFCQNVR----FLKELIELDI 488
+ H L++LDLS N+ + DAG ++VR L++L+ DI
Sbjct: 393 TLLANH--SLRELDLS-NNCLGDAGILQLVESVRQPGCLLEQLVLYDI 437
Score = 96.7 bits (239), Expect = 5e-20
Identities = 103/374 (27%), Positives = 165/374 (44%), Gaps = 23/374 (6%)
Query: 115 DLEELDISWNGFVGGTLLSITQQMHLVSKLKILRLGSCRLTTDDVQALGEAFEMIPELEE 174
D++ LDI + + L+ + +++RL C LT + + A + P L E
Sbjct: 4 DIQSLDIQCEELSDARWAEL---LPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
Query: 175 LNLSWNSKVGGNLPLILQKFQKGS-KIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLDL 233
LNL N + +LQ Q S KIQ + L +C LT L L L +L+ L L
Sbjct: 61 LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
Query: 234 SINRDIVGSLNSIAQGLKSTS-NLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCN 292
S N L + +GL L+ L+L C LS S + L + R + ++L +S N
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
Query: 293 -------KDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDL 345
+ L G +DSP QL LK L C +T+D+ L ++ ++L+EL L
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALK------LESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 346 SANKKMGSSSENLLSRLRFLPA-LKSLVINNCALESETFTALAEASVHLSALEVFNLSWN 404
+NK L L + L++L I C + ++ L +L+ +L+ N
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 405 KCVGGNLKLLLET-LKLSMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLSYND 463
+ +LL ET L+ L+ L + SCS + +SV+ L +L +S N+
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRF--LLELQIS-NN 351
Query: 464 SICDAGWTMFCQNV 477
+ DAG CQ +
Sbjct: 352 RLEDAGVRELCQGL 365
Score = 67.4 bits (163), Expect = 3e-11
Identities = 86/329 (26%), Positives = 147/329 (44%), Gaps = 18/329 (5%)
Query: 91 LDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVG--GTLLSITQQMHLVSKLKILR 148
L L NC LT A + + L LP L+EL +S N +G G L + +L+ L+
Sbjct: 90 LSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN-LLGDAGLQLLCEGLLDPQCRLEKLQ 148
Query: 149 LGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKG-SKIQMIELVD 207
L C L+ + L P+ +EL +S N + ++ Q + +++ ++L
Sbjct: 149 LEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLES 208
Query: 208 CSLTSEDGTFLGQLLPMLQSLEVLDLSINR-DIVGSLNSIAQGLKSTSNLKVLKLHSCGL 266
C +TS++ L ++ SL L L N+ VG L +S L+ L + CG+
Sbjct: 209 CGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGI 268
Query: 267 SQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLV---MLK---HLQVLDLHQC 320
+ K L R L++L L+ N +LG D A+L+ +L+ L+ L + C
Sbjct: 269 TAKGCGDLCRVLRAKESLKELSLAGN-ELG----DEGARLLCETLLEPGCQLESLWVKSC 323
Query: 321 SLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRL-RFLPALKSLVINNCALE 379
S TA + V+ L EL +S N+ + L L + L+ L + +C +
Sbjct: 324 SFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVS 383
Query: 380 SETFTALAEASVHLSALEVFNLSWNKCVG 408
+ ++LA + +L +LS N C+G
Sbjct: 384 DSSCSSLAATLLANHSLRELDLS-NNCLG 411
>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 110 bits (274), Expect = 4e-24
Identities = 114/408 (27%), Positives = 188/408 (46%), Gaps = 17/408 (4%)
Query: 93 LNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVGGTLLSITQQMHLVS-KLKILRLGS 151
L++CGLT A K++ + L P L EL++ N + + Q + S K++ L L +
Sbjct: 35 LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQN 94
Query: 152 CRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQ-KFQKGSKIQMIELVDCSL 210
C LT L +P L+EL+LS N L L+ + +++ ++L CSL
Sbjct: 95 CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSL 154
Query: 211 TSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLK-STSNLKVLKLHSCGLSQK 269
++ L +L + L +S N + + QGLK S L+ LKL SCG++
Sbjct: 155 SAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD 214
Query: 270 SVKILDAAFRYLGELRKLDLSCNKDLG--GGFEDSPAQLVMLKHLQVLDLHQCSLTADDV 327
+ + L LR+L L NK LG G E P L L+ L + +C +TA
Sbjct: 215 NCRDLCGIVASKASLRELALGSNK-LGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGC 273
Query: 328 MSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLRFLPA--LKSLVINNCALESETFTA 385
L +V+ +L+EL L+ N ++G LL P L+SL + +C+ + +
Sbjct: 274 GDLCRVLRAKESLKELSLAGN-ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSH 332
Query: 386 LAEASVHLSALEVFNLSWNKCVGGNLKLLLETLKLSMS-LQVLRLSSCSLVTEDVALLAS 444
+ L +S N+ ++ L + L S L+VL L+ C + + LA+
Sbjct: 333 FSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAA 392
Query: 445 VIQTGHLAKLQKLDLSYNDSICDAGWTMFCQNVR----FLKELIELDI 488
+ H L++LDLS N+ + DAG ++VR L++L+ DI
Sbjct: 393 TLLANH--SLRELDLS-NNCLGDAGILQLVESVRQPGCLLEQLVLYDI 437
Score = 96.7 bits (239), Expect = 5e-20
Identities = 103/374 (27%), Positives = 165/374 (44%), Gaps = 23/374 (6%)
Query: 115 DLEELDISWNGFVGGTLLSITQQMHLVSKLKILRLGSCRLTTDDVQALGEAFEMIPELEE 174
D++ LDI + + L+ + +++RL C LT + + A + P L E
Sbjct: 4 DIQSLDIQCEELSDARWAEL---LPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
Query: 175 LNLSWNSKVGGNLPLILQKFQKGS-KIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLDL 233
LNL N + +LQ Q S KIQ + L +C LT L L L +L+ L L
Sbjct: 61 LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
Query: 234 SINRDIVGSLNSIAQGLKSTS-NLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCN 292
S N L + +GL L+ L+L C LS S + L + R + ++L +S N
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
Query: 293 -------KDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDL 345
+ L G +DSP QL LK L C +T+D+ L ++ ++L+EL L
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALK------LESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 346 SANKKMGSSSENLLSRLRFLPA-LKSLVINNCALESETFTALAEASVHLSALEVFNLSWN 404
+NK L L + L++L I C + ++ L +L+ +L+ N
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 405 KCVGGNLKLLLET-LKLSMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLSYND 463
+ +LL ET L+ L+ L + SCS + +SV+ L +L +S N+
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRF--LLELQIS-NN 351
Query: 464 SICDAGWTMFCQNV 477
+ DAG CQ +
Sbjct: 352 RLEDAGVRELCQGL 365
Score = 67.4 bits (163), Expect = 3e-11
Identities = 86/329 (26%), Positives = 147/329 (44%), Gaps = 18/329 (5%)
Query: 91 LDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVG--GTLLSITQQMHLVSKLKILR 148
L L NC LT A + + L LP L+EL +S N +G G L + +L+ L+
Sbjct: 90 LSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN-LLGDAGLQLLCEGLLDPQCRLEKLQ 148
Query: 149 LGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKG-SKIQMIELVD 207
L C L+ + L P+ +EL +S N + ++ Q + +++ ++L
Sbjct: 149 LEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLES 208
Query: 208 CSLTSEDGTFLGQLLPMLQSLEVLDLSINR-DIVGSLNSIAQGLKSTSNLKVLKLHSCGL 266
C +TS++ L ++ SL L L N+ VG L +S L+ L + CG+
Sbjct: 209 CGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGI 268
Query: 267 SQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLV---MLK---HLQVLDLHQC 320
+ K L R L++L L+ N +LG D A+L+ +L+ L+ L + C
Sbjct: 269 TAKGCGDLCRVLRAKESLKELSLAGN-ELG----DEGARLLCETLLEPGCQLESLWVKSC 323
Query: 321 SLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRL-RFLPALKSLVINNCALE 379
S TA + V+ L EL +S N+ + L L + L+ L + +C +
Sbjct: 324 SFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVS 383
Query: 380 SETFTALAEASVHLSALEVFNLSWNKCVG 408
+ ++LA + +L +LS N C+G
Sbjct: 384 DSSCSSLAATLLANHSLRELDLS-NNCLG 411
>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 110 bits (274), Expect = 4e-24
Identities = 114/408 (27%), Positives = 188/408 (46%), Gaps = 17/408 (4%)
Query: 93 LNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVGGTLLSITQQMHLVS-KLKILRLGS 151
L++CGLT A K++ + L P L EL++ N + + Q + S K++ L L +
Sbjct: 35 LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQN 94
Query: 152 CRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQ-KFQKGSKIQMIELVDCSL 210
C LT L +P L+EL+LS N L L+ + +++ ++L CSL
Sbjct: 95 CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSL 154
Query: 211 TSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLK-STSNLKVLKLHSCGLSQK 269
++ L +L + L +S N + + QGLK S L+ LKL SCG++
Sbjct: 155 SAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD 214
Query: 270 SVKILDAAFRYLGELRKLDLSCNKDLG--GGFEDSPAQLVMLKHLQVLDLHQCSLTADDV 327
+ + L LR+L L NK LG G E P L L+ L + +C +TA
Sbjct: 215 NCRDLCGIVASKASLRELALGSNK-LGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGC 273
Query: 328 MSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLRFLPA--LKSLVINNCALESETFTA 385
L +V+ +L+EL L+ N ++G LL P L+SL + +C+ + +
Sbjct: 274 GDLCRVLRAKESLKELSLAGN-ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSH 332
Query: 386 LAEASVHLSALEVFNLSWNKCVGGNLKLLLETLKLSMS-LQVLRLSSCSLVTEDVALLAS 444
+ L +S N+ ++ L + L S L+VL L+ C + + LA+
Sbjct: 333 FSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAA 392
Query: 445 VIQTGHLAKLQKLDLSYNDSICDAGWTMFCQNVR----FLKELIELDI 488
+ H L++LDLS N+ + DAG ++VR L++L+ DI
Sbjct: 393 TLLANH--SLRELDLS-NNCLGDAGILQLVESVRQPGCLLEQLVLYDI 437
Score = 96.7 bits (239), Expect = 5e-20
Identities = 103/374 (27%), Positives = 165/374 (44%), Gaps = 23/374 (6%)
Query: 115 DLEELDISWNGFVGGTLLSITQQMHLVSKLKILRLGSCRLTTDDVQALGEAFEMIPELEE 174
D++ LDI + + L+ + +++RL C LT + + A + P L E
Sbjct: 4 DIQSLDIQCEELSDARWAEL---LPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
Query: 175 LNLSWNSKVGGNLPLILQKFQKGS-KIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLDL 233
LNL N + +LQ Q S KIQ + L +C LT L L L +L+ L L
Sbjct: 61 LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
Query: 234 SINRDIVGSLNSIAQGLKSTS-NLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCN 292
S N L + +GL L+ L+L C LS S + L + R + ++L +S N
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
Query: 293 -------KDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDL 345
+ L G +DSP QL LK L C +T+D+ L ++ ++L+EL L
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALK------LESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 346 SANKKMGSSSENLLSRLRFLPA-LKSLVINNCALESETFTALAEASVHLSALEVFNLSWN 404
+NK L L + L++L I C + ++ L +L+ +L+ N
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 405 KCVGGNLKLLLET-LKLSMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLSYND 463
+ +LL ET L+ L+ L + SCS + +SV+ L +L +S N+
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRF--LLELQIS-NN 351
Query: 464 SICDAGWTMFCQNV 477
+ DAG CQ +
Sbjct: 352 RLEDAGVRELCQGL 365
Score = 67.4 bits (163), Expect = 3e-11
Identities = 86/329 (26%), Positives = 147/329 (44%), Gaps = 18/329 (5%)
Query: 91 LDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVG--GTLLSITQQMHLVSKLKILR 148
L L NC LT A + + L LP L+EL +S N +G G L + +L+ L+
Sbjct: 90 LSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN-LLGDAGLQLLCEGLLDPQCRLEKLQ 148
Query: 149 LGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKG-SKIQMIELVD 207
L C L+ + L P+ +EL +S N + ++ Q + +++ ++L
Sbjct: 149 LEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLES 208
Query: 208 CSLTSEDGTFLGQLLPMLQSLEVLDLSINR-DIVGSLNSIAQGLKSTSNLKVLKLHSCGL 266
C +TS++ L ++ SL L L N+ VG L +S L+ L + CG+
Sbjct: 209 CGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGI 268
Query: 267 SQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLV---MLK---HLQVLDLHQC 320
+ K L R L++L L+ N +LG D A+L+ +L+ L+ L + C
Sbjct: 269 TAKGCGDLCRVLRAKESLKELSLAGN-ELG----DEGARLLCETLLEPGCQLESLWVKSC 323
Query: 321 SLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRL-RFLPALKSLVINNCALE 379
S TA + V+ L EL +S N+ + L L + L+ L + +C +
Sbjct: 324 SFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVS 383
Query: 380 SETFTALAEASVHLSALEVFNLSWNKCVG 408
+ ++LA + +L +LS N C+G
Sbjct: 384 DSSCSSLAATLLANHSLRELDLS-NNCLG 411
>gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 110 bits (274), Expect = 4e-24
Identities = 114/408 (27%), Positives = 188/408 (46%), Gaps = 17/408 (4%)
Query: 93 LNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVGGTLLSITQQMHLVS-KLKILRLGS 151
L++CGLT A K++ + L P L EL++ N + + Q + S K++ L L +
Sbjct: 35 LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQN 94
Query: 152 CRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQ-KFQKGSKIQMIELVDCSL 210
C LT L +P L+EL+LS N L L+ + +++ ++L CSL
Sbjct: 95 CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSL 154
Query: 211 TSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLK-STSNLKVLKLHSCGLSQK 269
++ L +L + L +S N + + QGLK S L+ LKL SCG++
Sbjct: 155 SAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD 214
Query: 270 SVKILDAAFRYLGELRKLDLSCNKDLG--GGFEDSPAQLVMLKHLQVLDLHQCSLTADDV 327
+ + L LR+L L NK LG G E P L L+ L + +C +TA
Sbjct: 215 NCRDLCGIVASKASLRELALGSNK-LGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGC 273
Query: 328 MSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLRFLPA--LKSLVINNCALESETFTA 385
L +V+ +L+EL L+ N ++G LL P L+SL + +C+ + +
Sbjct: 274 GDLCRVLRAKESLKELSLAGN-ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSH 332
Query: 386 LAEASVHLSALEVFNLSWNKCVGGNLKLLLETLKLSMS-LQVLRLSSCSLVTEDVALLAS 444
+ L +S N+ ++ L + L S L+VL L+ C + + LA+
Sbjct: 333 FSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAA 392
Query: 445 VIQTGHLAKLQKLDLSYNDSICDAGWTMFCQNVR----FLKELIELDI 488
+ H L++LDLS N+ + DAG ++VR L++L+ DI
Sbjct: 393 TLLANH--SLRELDLS-NNCLGDAGILQLVESVRQPGCLLEQLVLYDI 437
Score = 96.7 bits (239), Expect = 5e-20
Identities = 103/374 (27%), Positives = 165/374 (44%), Gaps = 23/374 (6%)
Query: 115 DLEELDISWNGFVGGTLLSITQQMHLVSKLKILRLGSCRLTTDDVQALGEAFEMIPELEE 174
D++ LDI + + L+ + +++RL C LT + + A + P L E
Sbjct: 4 DIQSLDIQCEELSDARWAEL---LPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
Query: 175 LNLSWNSKVGGNLPLILQKFQKGS-KIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLDL 233
LNL N + +LQ Q S KIQ + L +C LT L L L +L+ L L
Sbjct: 61 LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
Query: 234 SINRDIVGSLNSIAQGLKSTS-NLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCN 292
S N L + +GL L+ L+L C LS S + L + R + ++L +S N
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
Query: 293 -------KDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDL 345
+ L G +DSP QL LK L C +T+D+ L ++ ++L+EL L
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALK------LESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 346 SANKKMGSSSENLLSRLRFLPA-LKSLVINNCALESETFTALAEASVHLSALEVFNLSWN 404
+NK L L + L++L I C + ++ L +L+ +L+ N
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 405 KCVGGNLKLLLET-LKLSMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLSYND 463
+ +LL ET L+ L+ L + SCS + +SV+ L +L +S N+
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRF--LLELQIS-NN 351
Query: 464 SICDAGWTMFCQNV 477
+ DAG CQ +
Sbjct: 352 RLEDAGVRELCQGL 365
Score = 67.4 bits (163), Expect = 3e-11
Identities = 86/329 (26%), Positives = 147/329 (44%), Gaps = 18/329 (5%)
Query: 91 LDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVG--GTLLSITQQMHLVSKLKILR 148
L L NC LT A + + L LP L+EL +S N +G G L + +L+ L+
Sbjct: 90 LSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN-LLGDAGLQLLCEGLLDPQCRLEKLQ 148
Query: 149 LGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKG-SKIQMIELVD 207
L C L+ + L P+ +EL +S N + ++ Q + +++ ++L
Sbjct: 149 LEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLES 208
Query: 208 CSLTSEDGTFLGQLLPMLQSLEVLDLSINR-DIVGSLNSIAQGLKSTSNLKVLKLHSCGL 266
C +TS++ L ++ SL L L N+ VG L +S L+ L + CG+
Sbjct: 209 CGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGI 268
Query: 267 SQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLV---MLK---HLQVLDLHQC 320
+ K L R L++L L+ N +LG D A+L+ +L+ L+ L + C
Sbjct: 269 TAKGCGDLCRVLRAKESLKELSLAGN-ELG----DEGARLLCETLLEPGCQLESLWVKSC 323
Query: 321 SLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRL-RFLPALKSLVINNCALE 379
S TA + V+ L EL +S N+ + L L + L+ L + +C +
Sbjct: 324 SFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVS 383
Query: 380 SETFTALAEASVHLSALEVFNLSWNKCVG 408
+ ++LA + +L +LS N C+G
Sbjct: 384 DSSCSSLAATLLANHSLRELDLS-NNCLG 411
>gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 110 bits (274), Expect = 4e-24
Identities = 114/408 (27%), Positives = 188/408 (46%), Gaps = 17/408 (4%)
Query: 93 LNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVGGTLLSITQQMHLVS-KLKILRLGS 151
L++CGLT A K++ + L P L EL++ N + + Q + S K++ L L +
Sbjct: 35 LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQN 94
Query: 152 CRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQ-KFQKGSKIQMIELVDCSL 210
C LT L +P L+EL+LS N L L+ + +++ ++L CSL
Sbjct: 95 CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSL 154
Query: 211 TSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLK-STSNLKVLKLHSCGLSQK 269
++ L +L + L +S N + + QGLK S L+ LKL SCG++
Sbjct: 155 SAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD 214
Query: 270 SVKILDAAFRYLGELRKLDLSCNKDLG--GGFEDSPAQLVMLKHLQVLDLHQCSLTADDV 327
+ + L LR+L L NK LG G E P L L+ L + +C +TA
Sbjct: 215 NCRDLCGIVASKASLRELALGSNK-LGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGC 273
Query: 328 MSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLRFLPA--LKSLVINNCALESETFTA 385
L +V+ +L+EL L+ N ++G LL P L+SL + +C+ + +
Sbjct: 274 GDLCRVLRAKESLKELSLAGN-ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSH 332
Query: 386 LAEASVHLSALEVFNLSWNKCVGGNLKLLLETLKLSMS-LQVLRLSSCSLVTEDVALLAS 444
+ L +S N+ ++ L + L S L+VL L+ C + + LA+
Sbjct: 333 FSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAA 392
Query: 445 VIQTGHLAKLQKLDLSYNDSICDAGWTMFCQNVR----FLKELIELDI 488
+ H L++LDLS N+ + DAG ++VR L++L+ DI
Sbjct: 393 TLLANH--SLRELDLS-NNCLGDAGILQLVESVRQPGCLLEQLVLYDI 437
Score = 96.7 bits (239), Expect = 5e-20
Identities = 103/374 (27%), Positives = 165/374 (44%), Gaps = 23/374 (6%)
Query: 115 DLEELDISWNGFVGGTLLSITQQMHLVSKLKILRLGSCRLTTDDVQALGEAFEMIPELEE 174
D++ LDI + + L+ + +++RL C LT + + A + P L E
Sbjct: 4 DIQSLDIQCEELSDARWAEL---LPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
Query: 175 LNLSWNSKVGGNLPLILQKFQKGS-KIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLDL 233
LNL N + +LQ Q S KIQ + L +C LT L L L +L+ L L
Sbjct: 61 LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
Query: 234 SINRDIVGSLNSIAQGLKSTS-NLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCN 292
S N L + +GL L+ L+L C LS S + L + R + ++L +S N
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
Query: 293 -------KDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDL 345
+ L G +DSP QL LK L C +T+D+ L ++ ++L+EL L
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALK------LESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 346 SANKKMGSSSENLLSRLRFLPA-LKSLVINNCALESETFTALAEASVHLSALEVFNLSWN 404
+NK L L + L++L I C + ++ L +L+ +L+ N
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 405 KCVGGNLKLLLET-LKLSMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLSYND 463
+ +LL ET L+ L+ L + SCS + +SV+ L +L +S N+
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRF--LLELQIS-NN 351
Query: 464 SICDAGWTMFCQNV 477
+ DAG CQ +
Sbjct: 352 RLEDAGVRELCQGL 365
Score = 67.4 bits (163), Expect = 3e-11
Identities = 86/329 (26%), Positives = 147/329 (44%), Gaps = 18/329 (5%)
Query: 91 LDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVG--GTLLSITQQMHLVSKLKILR 148
L L NC LT A + + L LP L+EL +S N +G G L + +L+ L+
Sbjct: 90 LSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN-LLGDAGLQLLCEGLLDPQCRLEKLQ 148
Query: 149 LGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKG-SKIQMIELVD 207
L C L+ + L P+ +EL +S N + ++ Q + +++ ++L
Sbjct: 149 LEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLES 208
Query: 208 CSLTSEDGTFLGQLLPMLQSLEVLDLSINR-DIVGSLNSIAQGLKSTSNLKVLKLHSCGL 266
C +TS++ L ++ SL L L N+ VG L +S L+ L + CG+
Sbjct: 209 CGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGI 268
Query: 267 SQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLV---MLK---HLQVLDLHQC 320
+ K L R L++L L+ N +LG D A+L+ +L+ L+ L + C
Sbjct: 269 TAKGCGDLCRVLRAKESLKELSLAGN-ELG----DEGARLLCETLLEPGCQLESLWVKSC 323
Query: 321 SLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRL-RFLPALKSLVINNCALE 379
S TA + V+ L EL +S N+ + L L + L+ L + +C +
Sbjct: 324 SFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVS 383
Query: 380 SETFTALAEASVHLSALEVFNLSWNKCVG 408
+ ++LA + +L +LS N C+G
Sbjct: 384 DSSCSSLAATLLANHSLRELDLS-NNCLG 411
>gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 110 bits (274), Expect = 4e-24
Identities = 114/408 (27%), Positives = 188/408 (46%), Gaps = 17/408 (4%)
Query: 93 LNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVGGTLLSITQQMHLVS-KLKILRLGS 151
L++CGLT A K++ + L P L EL++ N + + Q + S K++ L L +
Sbjct: 35 LDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQN 94
Query: 152 CRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQ-KFQKGSKIQMIELVDCSL 210
C LT L +P L+EL+LS N L L+ + +++ ++L CSL
Sbjct: 95 CCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSL 154
Query: 211 TSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLK-STSNLKVLKLHSCGLSQK 269
++ L +L + L +S N + + QGLK S L+ LKL SCG++
Sbjct: 155 SAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSD 214
Query: 270 SVKILDAAFRYLGELRKLDLSCNKDLG--GGFEDSPAQLVMLKHLQVLDLHQCSLTADDV 327
+ + L LR+L L NK LG G E P L L+ L + +C +TA
Sbjct: 215 NCRDLCGIVASKASLRELALGSNK-LGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGC 273
Query: 328 MSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLRFLPA--LKSLVINNCALESETFTA 385
L +V+ +L+EL L+ N ++G LL P L+SL + +C+ + +
Sbjct: 274 GDLCRVLRAKESLKELSLAGN-ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSH 332
Query: 386 LAEASVHLSALEVFNLSWNKCVGGNLKLLLETLKLSMS-LQVLRLSSCSLVTEDVALLAS 444
+ L +S N+ ++ L + L S L+VL L+ C + + LA+
Sbjct: 333 FSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAA 392
Query: 445 VIQTGHLAKLQKLDLSYNDSICDAGWTMFCQNVR----FLKELIELDI 488
+ H L++LDLS N+ + DAG ++VR L++L+ DI
Sbjct: 393 TLLANH--SLRELDLS-NNCLGDAGILQLVESVRQPGCLLEQLVLYDI 437
Score = 96.7 bits (239), Expect = 5e-20
Identities = 103/374 (27%), Positives = 165/374 (44%), Gaps = 23/374 (6%)
Query: 115 DLEELDISWNGFVGGTLLSITQQMHLVSKLKILRLGSCRLTTDDVQALGEAFEMIPELEE 174
D++ LDI + + L+ + +++RL C LT + + A + P L E
Sbjct: 4 DIQSLDIQCEELSDARWAEL---LPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAE 60
Query: 175 LNLSWNSKVGGNLPLILQKFQKGS-KIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLDL 233
LNL N + +LQ Q S KIQ + L +C LT L L L +L+ L L
Sbjct: 61 LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120
Query: 234 SINRDIVGSLNSIAQGLKSTS-NLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCN 292
S N L + +GL L+ L+L C LS S + L + R + ++L +S N
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180
Query: 293 -------KDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDL 345
+ L G +DSP QL LK L C +T+D+ L ++ ++L+EL L
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALK------LESCGVTSDNCRDLCGIVASKASLRELAL 234
Query: 346 SANKKMGSSSENLLSRLRFLPA-LKSLVINNCALESETFTALAEASVHLSALEVFNLSWN 404
+NK L L + L++L I C + ++ L +L+ +L+ N
Sbjct: 235 GSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGN 294
Query: 405 KCVGGNLKLLLET-LKLSMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLSYND 463
+ +LL ET L+ L+ L + SCS + +SV+ L +L +S N+
Sbjct: 295 ELGDEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRF--LLELQIS-NN 351
Query: 464 SICDAGWTMFCQNV 477
+ DAG CQ +
Sbjct: 352 RLEDAGVRELCQGL 365
Score = 67.4 bits (163), Expect = 3e-11
Identities = 86/329 (26%), Positives = 147/329 (44%), Gaps = 18/329 (5%)
Query: 91 LDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVG--GTLLSITQQMHLVSKLKILR 148
L L NC LT A + + L LP L+EL +S N +G G L + +L+ L+
Sbjct: 90 LSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDN-LLGDAGLQLLCEGLLDPQCRLEKLQ 148
Query: 149 LGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKG-SKIQMIELVD 207
L C L+ + L P+ +EL +S N + ++ Q + +++ ++L
Sbjct: 149 LEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLES 208
Query: 208 CSLTSEDGTFLGQLLPMLQSLEVLDLSINR-DIVGSLNSIAQGLKSTSNLKVLKLHSCGL 266
C +TS++ L ++ SL L L N+ VG L +S L+ L + CG+
Sbjct: 209 CGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGI 268
Query: 267 SQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLV---MLK---HLQVLDLHQC 320
+ K L R L++L L+ N +LG D A+L+ +L+ L+ L + C
Sbjct: 269 TAKGCGDLCRVLRAKESLKELSLAGN-ELG----DEGARLLCETLLEPGCQLESLWVKSC 323
Query: 321 SLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRL-RFLPALKSLVINNCALE 379
S TA + V+ L EL +S N+ + L L + L+ L + +C +
Sbjct: 324 SFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVS 383
Query: 380 SETFTALAEASVHLSALEVFNLSWNKCVG 408
+ ++LA + +L +LS N C+G
Sbjct: 384 DSSCSSLAATLLANHSLRELDLS-NNCLG 411
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 75.9 bits (185), Expect = 9e-14
Identities = 87/295 (29%), Positives = 139/295 (47%), Gaps = 21/295 (7%)
Query: 91 LDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVG--GTLLSITQQMHLVSKLKILR 148
L L C ++++ +++ A L +L +D+S NG VG G +L H +L++++
Sbjct: 747 LRLKRCRISSSACEDLSAALIANKNLTRMDLSGNG-VGFPGMMLLCEGLRHPQCRLQMIQ 805
Query: 149 LGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKG-SKIQMIELVD 207
L C+L + Q + P L EL+L+ N+ L L+ Q + +++ + L
Sbjct: 806 LRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKI 865
Query: 208 CSLTSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLN--SIAQGLK-STSNLKVLKLHSC 264
C LT+ L L + QSL LDLS+N +G L + +GL+ T L+ L+L C
Sbjct: 866 CRLTAAACDELASTLSVNQSLRELDLSLNE--LGDLGVLLLCEGLRHPTCKLQTLRLGIC 923
Query: 265 GLSQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLVM--LKH----LQVLDLH 318
L + + L + LR+LDLS N DLG D L+ L+H LQ L L
Sbjct: 924 RLGSAACEGLSVVLQANHNLRELDLSFN-DLG----DWGLWLLAEGLQHPACRLQKLWLD 978
Query: 319 QCSLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLRFLPALKSLVI 373
C LTA +L + + L +L L+ N +G + LL + P K V+
Sbjct: 979 SCGLTAKACENLYFTLGINQTLTDLYLT-NNALGDTGVRLLCKRLSHPGCKLRVL 1032
Score = 73.9 bits (180), Expect = 3e-13
Identities = 73/243 (30%), Positives = 116/243 (47%), Gaps = 14/243 (5%)
Query: 230 VLDLSINRDIVGS--LNSIAQGLKSTS-NLKVLKLHSCGLSQKSVKILDAAFRYLGELRK 286
+++LS+ R+ +GS + + QGL+ + L+ L+L C +S + + L AA L +
Sbjct: 715 LIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTR 774
Query: 287 LDLSCNKDLGGGFEDSPAQLVMLKH----LQVLDLHQCSLTADDVMSLTQVIPLLSNLQE 342
+DLS N G GF L+H LQ++ L +C L + + V+ +L E
Sbjct: 775 MDLSGN---GVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVE 831
Query: 343 LDLSANKKMGSSSENLLSRLRF-LPALKSLVINNCALESETFTALAEASVHLSALEVFNL 401
LDL+ N L LR + L++L + C L + LA +L +L
Sbjct: 832 LDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDL 891
Query: 402 SWNKCVGGNLKLLLETLKL-SMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLS 460
S N+ + LL E L+ + LQ LRL C L + L+ V+Q H L++LDLS
Sbjct: 892 SLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANH--NLRELDLS 949
Query: 461 YND 463
+ND
Sbjct: 950 FND 952
Score = 62.4 bits (150), Expect = 1e-09
Identities = 84/291 (28%), Positives = 129/291 (44%), Gaps = 9/291 (3%)
Query: 98 LTTADMKEMVALLPFLPDLEELDISWNGFVGGTLLSITQQM-HLVSKLKILRLGSCRLTT 156
L A + + A L P+L EL + N + + Q + H KL+ LRL CR+++
Sbjct: 697 LLDAYSEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISS 756
Query: 157 DDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGS-KIQMIELVDCSLTSEDG 215
+ L A L ++LS N + L+ + + ++QMI+L C L S
Sbjct: 757 SACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGAC 816
Query: 216 TFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLK-STSNLKVLKLHSCGLSQKSVKIL 274
+ +L L LDL+ N L + QGL+ L+ L L C L+ + L
Sbjct: 817 QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 876
Query: 275 DAAFRYLGELRKLDLSCNK--DLGGGFEDSPAQLVMLKHLQVLDLHQCSLTADDVMSLTQ 332
+ LR+LDLS N+ DLG + K LQ L L C L + L+
Sbjct: 877 ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCK-LQTLRLGICRLGSAACEGLSV 935
Query: 333 VIPLLSNLQELDLSANKKMGSSSENLLSRLRFLPA--LKSLVINNCALESE 381
V+ NL+ELDLS N +G LL+ PA L+ L +++C L ++
Sbjct: 936 VLQANHNLRELDLSFN-DLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAK 985
Score = 54.3 bits (129), Expect = 3e-07
Identities = 49/150 (32%), Positives = 69/150 (46%), Gaps = 2/150 (1%)
Query: 89 KCLDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVG-GTLLSITQQMHLVSKLKIL 147
+ L L C LT A E+ + L L ELD+S N G LL H KL+ L
Sbjct: 859 RTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTL 918
Query: 148 RLGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQ-KGSKIQMIELV 206
RLG CRL + + L + L EL+LS+N L L+ + Q ++Q + L
Sbjct: 919 RLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLD 978
Query: 207 DCSLTSEDGTFLGQLLPMLQSLEVLDLSIN 236
C LT++ L L + Q+L L L+ N
Sbjct: 979 SCGLTAKACENLYFTLGINQTLTDLYLTNN 1008
>gi|116268109 nucleotide-binding oligomerization domains 27 [Homo
sapiens]
Length = 1866
Score = 74.7 bits (182), Expect = 2e-13
Identities = 107/441 (24%), Positives = 177/441 (40%), Gaps = 68/441 (15%)
Query: 44 SQPSDWIQKTATSETAKPLSSEMEWRSSMEKNEHFLQKLGKKAVNKCLDLNNCGLTTADM 103
+Q S + + + SET + L ++E+ E E L L +C L
Sbjct: 1404 AQASGSVTEISISETQQQLCVQLEFPRQEENPEAV-----------ALRLAHCDLGAHHS 1452
Query: 104 KEMVALLPFLPDLEELDISWNGFV---GGTLLSITQQMHLVSKLKILRLGSCRLTTDDVQ 160
+ L+ L++L +S + L + + +S+LK RL S ++T+ +
Sbjct: 1453 LLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVSTEGLA 1512
Query: 161 ALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGSKIQMIELVDCSLTSEDGTFLGQ 220
L LEEL+LS N +++ + ++ ++L L S L
Sbjct: 1513 HLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTLALLTH 1572
Query: 221 LLPMLQSLEVLDLSINRDIVGSLNS--IAQGLKSTSNLKVLKLHSCGLSQKSVKILDAAF 278
L + L+ L +NR+ +G + +++ L++ ++L+ L L + V+ L
Sbjct: 1573 RLSQMTCLQ--SLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATIL 1630
Query: 279 RYLGELRKLDLSCNKDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIP--- 335
L ELRK+DLS N G LV+ + L+ L L +L + L Q +P
Sbjct: 1631 PGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQELPQHL 1690
Query: 336 --------------LLSNLQELDLSANKKMGSSSENLLSR--LRF---LPALKSLVINNC 376
LS Q LD S + + S +EN L+ LRF LP L+ + + +C
Sbjct: 1691 RVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLAGGVLRFCMELPLLRQIDLVSC 1750
Query: 377 ALESETFTALAEASVHLSALEVFNLSWNKCVG-------------GNLK----------- 412
++++T L + ALEV LSWN G LK
Sbjct: 1751 KIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKNQITA 1810
Query: 413 ----LLLETLKLSMSLQVLRL 429
LL E L S+QV+RL
Sbjct: 1811 LGAWLLAEGLAQGSSIQVIRL 1831
Score = 61.2 bits (147), Expect = 2e-09
Identities = 108/472 (22%), Positives = 197/472 (41%), Gaps = 33/472 (6%)
Query: 61 PLSSEMEWRSSMEKNEHFLQKLGKKAVNKCLDLNNCGLTTADMKEMVALLPFLPDLEELD 120
P +++ RS HF ++ V C C L+ ++ + LL DL ++D
Sbjct: 1191 PRVKKVDLRSLHHATLHFRSNEEEEGVC-CGRFTGCSLSQEHVESLCWLLSKCKDLSQVD 1249
Query: 121 ISWNGFVGGTLLSITQQMHLVSKLKILRLGSCRLTTDDVQALGEAFEMIPELEELNLSWN 180
+S N L + + + V +L L ++ + L E P + E +++
Sbjct: 1250 LSANLLGDSGLRCLLECLPQVPISGLLDLSHNSISQESALYLLETLPSCPRVREASVNLG 1309
Query: 181 SKVGGNLPLILQKFQKGSKIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLDLSINRDIV 240
S+ + ++ Q G +++ E CS E + L L +SL++ +L++ + +
Sbjct: 1310 SEQSFRIH-FSREDQAGKTLRLSE---CSFRPEHVSRLATGLS--KSLQLTELTLTQCCL 1363
Query: 241 G--SLNSIAQGLKSTSNLKVLKLHSCGLSQKSV-KILDAAFRYLGELRKLDLS------C 291
G L + + + L L++ + V +L+ + G + ++ +S C
Sbjct: 1364 GQKQLAILLSLVGRPAGLFSLRVQEPWADRARVLSLLEVCAQASGSVTEISISETQQQLC 1423
Query: 292 NKDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLS---AN 348
+ E++P + L L C L A + + Q++ + LQ+L LS
Sbjct: 1424 VQLEFPRQEENPEAV-------ALRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLC 1476
Query: 349 KKMGSSSENLLSRLRFLPALKSLVINNCALESETFTALAEASVHLSALEVFNLSWNKCVG 408
+ +SS L S L L LK+ + + + +E LA H LE +LS N+
Sbjct: 1477 EDDDASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDE 1536
Query: 409 GNLKLLLETLKLSMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLSYNDSICDA 468
K L+ L+ L+ L LS L + +ALL + + LQ L L+ N SI D
Sbjct: 1537 EGTKALMRALEGKWMLKRLDLSHLLLNSSTLALLTH--RLSQMTCLQSLRLNRN-SIGDV 1593
Query: 469 GWTMFCQNVRFLKELIELDISLRPSNFRDCGQWFRHLLYAVTKLPQITEIGM 520
G + +R L ELD+S + D G +HL + LP++ +I +
Sbjct: 1594 GCCHLSEALRAATSLEELDLS--HNQIGDAG--VQHLATILPGLPELRKIDL 1641
Score = 60.8 bits (146), Expect = 3e-09
Identities = 110/427 (25%), Positives = 170/427 (39%), Gaps = 73/427 (17%)
Query: 61 PLSSEMEWRSSMEKNEHFLQKLGKKAVNKCLDLNNCGLTTADMKEMVALLPFLPDLEELD 120
P + E + + + E Q+ G ++ + L L C L D + ++ALL P LEE+D
Sbjct: 817 PTETTAELQRAPDLQESDGQRKGAQSRSLTLRLQKCQLQVHDAEALIALLQEGPHLEEVD 876
Query: 121 ISWNGF--VGGTLLS-ITQQMHLVSKLKILRLGSCRLTTDDVQALGEAFEMIPELEELNL 177
+S N G L++ Q+H+ KL + G L+ V + A L EL++
Sbjct: 877 LSGNQLEDEGCRLMAEAASQLHIARKLDLSDNG---LSVAGVHCVLRAVSACWTLAELHI 933
Query: 178 SWNSKVGGNLPLILQKFQKGSKIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLDLSINR 237
S K + + QKG + E FL L MLQ L LS R
Sbjct: 934 SLQHKTVIFMFAQEPEEQKGPQ-------------ERAAFLDSL--MLQMPSELPLSSRR 978
Query: 238 DIVGSLNSIAQGLKSTSNLKVLKLHSCGLSQKSVKILDAAFR---YLGELRKLDLSCNKD 294
++L CGL +K ++ L A +LG L LD S N
Sbjct: 979 ---------------------MRLTHCGLQEKHLEQLCKALGGSCHLGHLH-LDFSGNA- 1015
Query: 295 LGGGFEDSPAQLVM-LKHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLSANKK--- 350
LG AQL+ L LQ L+L + L+ D V+ L + L L LD+S +
Sbjct: 1016 LGDEGAARLAQLLPGLGALQSLNLSENGLSLDAVLGLVRCFSTLQWLFRLDISFESQHIL 1075
Query: 351 ------------------MGSSSENLLSRLRFLPALKSLVINNCALESETFTALAEASVH 392
++++ L R R +P +SL ++ C LE + T L
Sbjct: 1076 LRGDKTSRDMWATGSLPDFPAAAKFLGFRQRCIP--RSLCLSECPLEPPSLTRLCATLKD 1133
Query: 393 LSALEVFNLSWNKCVGGNLKLLLETLKLSMSLQVLRLSSCSLVTEDVALLASVIQTGHLA 452
LS +L+ LL+ L L +L+LS L + LLA+ +
Sbjct: 1134 CPGPLELQLSCEFLSDQSLETLLDCLPQLPQLSLLQLSQTGLSPKSPFLLANTLSL--CP 1191
Query: 453 KLQKLDL 459
+++K+DL
Sbjct: 1192 RVKKVDL 1198
Score = 56.6 bits (135), Expect = 6e-08
Identities = 76/317 (23%), Positives = 133/317 (41%), Gaps = 9/317 (2%)
Query: 170 PELEELNLSWNSKVGGNLPLILQKFQKGSKIQMIELVDCSLTSEDGT---FLGQLLPMLQ 226
PE L L+ + L+ Q + +++Q + L +L +D L LL L
Sbjct: 1435 PEAVALRLAHCDLGAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLS 1494
Query: 227 SLEVLDLSINRDIVGSLNSIAQGLKSTSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRK 286
L+ L+ + L +A GL +L+ L L + ++ K L A L++
Sbjct: 1495 ELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKR 1554
Query: 287 LDLSCNKDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLS 346
LDLS +L + LQ L L++ S+ L++ + ++L+ELDLS
Sbjct: 1555 LDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLS 1614
Query: 347 ANKKMGSSSENLLSRLRFLPALKSLVINNCALESETFTALAEASVHLSALEVFNLSWNKC 406
N+ + ++L + L LP L+ + ++ ++ S LAE+ V LE L N
Sbjct: 1615 HNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNAL 1674
Query: 407 VGGNLKLLLETLKLSMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLSYNDSIC 466
G+ L +L L+VL L L LA + L+++ L+ N+
Sbjct: 1675 --GDPTALGLAQELPQHLRVLHLPFSHLGPGGALSLAQALDGS--PHLEEISLAENN--L 1728
Query: 467 DAGWTMFCQNVRFLKEL 483
G FC + L+++
Sbjct: 1729 AGGVLRFCMELPLLRQI 1745
Score = 55.5 bits (132), Expect = 1e-07
Identities = 59/247 (23%), Positives = 105/247 (42%), Gaps = 6/247 (2%)
Query: 91 LDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVGGTLLSITQQMHLVSKLKILRLG 150
LDL++ + A ++ + +LP LP+L ++D+S N + + + + L +L+ L LG
Sbjct: 1611 LDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLG 1670
Query: 151 SCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGSKIQMIELVDCSL 210
L D ALG A E+ L L+L ++ G + Q ++ I L + +L
Sbjct: 1671 CNAL--GDPTALGLAQELPQHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNL 1728
Query: 211 TSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLKSTSNLKVLKLHSCGLSQKS 270
F + LP+L+ ++++ I+ L S S L+V+ L L ++
Sbjct: 1729 AGGVLRFCME-LPLLRQIDLVSCKIDNQTAKLLTS---SFTSCPALEVILLSWNLLGDEA 1784
Query: 271 VKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTADDVMSL 330
L +G L+++DL N+ G L +QV+ L + D L
Sbjct: 1785 AAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPIPCDMAQHL 1844
Query: 331 TQVIPLL 337
P L
Sbjct: 1845 KSQEPRL 1851
Score = 50.8 bits (120), Expect = 3e-06
Identities = 93/399 (23%), Positives = 156/399 (39%), Gaps = 49/399 (12%)
Query: 93 LNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVGGT--LLSITQQMHLVSKLKILRLG 150
L +CGL ++++ L L L + ++G G + Q + + L+ L L
Sbjct: 981 LTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQLLPGLGALQSLNLS 1040
Query: 151 SCRLTTDDVQALGEAFEMIPELEELNLSWNSK--------------VGGNLPLI-----L 191
L+ D V L F + L L++S+ S+ G+LP
Sbjct: 1041 ENGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRGDKTSRDMWATGSLPDFPAAAKF 1100
Query: 192 QKFQKGSKIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLK 251
F++ + + L +C L T L L L LS SL ++ L
Sbjct: 1101 LGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPLELQLSCEFLSDQSLETLLDCLP 1160
Query: 252 STSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLVMLKH 311
L +L+L GLS KS +L ++K+DL F + + +
Sbjct: 1161 QLPQLSLLQLSQTGLSPKSPFLLANTLSLCPRVKKVDLRSLHHATLHFRSNEEE----EG 1216
Query: 312 LQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLRFLP--ALK 369
+ CSL+ + V SL ++ +L ++DLSAN S LL L +P L
Sbjct: 1217 VCCGRFTGCSLSQEHVESLCWLLSKCKDLSQVDLSANLLGDSGLRCLLECLPQVPISGLL 1276
Query: 370 SLVINNCALESETF--------TALAEASVHLSALEVFNLSWNK--CVGGNLKL------ 413
L N+ + ES + + EASV+L + + F + +++ G L+L
Sbjct: 1277 DLSHNSISQESALYLLETLPSCPRVREASVNLGSEQSFRIHFSREDQAGKTLRLSECSFR 1336
Query: 414 ------LLETLKLSMSLQVLRLSSCSLVTEDVALLASVI 446
L L S+ L L L+ C L + +A+L S++
Sbjct: 1337 PEHVSRLATGLSKSLQLTELTLTQCCLGQKQLAILLSLV 1375
Score = 43.9 bits (102), Expect = 4e-04
Identities = 58/226 (25%), Positives = 97/226 (42%), Gaps = 23/226 (10%)
Query: 282 GELRKLDLSCNKDLGGGFEDSPAQ-LVMLKHLQVLDLHQCSLTADDVMSLTQVIPLLSNL 340
G++ L K G F ++ ++ L + LQ+L L +TA + L + +PL L
Sbjct: 686 GQIENLSFKSRK-CGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQL 744
Query: 341 QELDLSANKKMGSSSENLLSRLRFLPALKSLVINNCALESETFTALAEASV------HLS 394
+E+ N+ N++ L LP L+ L +++ ++ T LA +V L
Sbjct: 745 KEVSFRDNQLSDQVVLNIVEVLPHLPRLRKLDLSSNSICVSTLLCLARVAVTCPTVRMLQ 804
Query: 395 ALE---VFNLSWNKCVGGNLKLLLETLK--------LSMSLQVLRLSSCSLVTEDVALLA 443
A E +F LS L+ + + S SL LRL C L D L
Sbjct: 805 AREADLIFLLSPPTETTAELQRAPDLQESDGQRKGAQSRSL-TLRLQKCQLQVHDAEALI 863
Query: 444 SVIQTGHLAKLQKLDLSYNDSICDAGWTMFCQNVRFLKELIELDIS 489
+++Q G L+++DLS N + D G + + L +LD+S
Sbjct: 864 ALLQEG--PHLEEVDLSGN-QLEDEGCRLMAEAASQLHIARKLDLS 906
Score = 37.7 bits (86), Expect = 0.028
Identities = 74/310 (23%), Positives = 117/310 (37%), Gaps = 46/310 (14%)
Query: 218 LGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLKSTSNLKVLKLHSCGLSQKSVKILDAA 277
L + LP + L++L L+ ++ ++ + + L LK + LS + V +
Sbjct: 706 LSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSDQVVLNIVEV 765
Query: 278 FRYLGELRKLDLSCNKDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTADDVMSL---TQVI 334
+L LRKLDLS N V +++L + AD + L T+
Sbjct: 766 LPHLPRLRKLDLSSNSICVSTLLCLARVAVTCPTVRMLQARE----ADLIFLLSPPTETT 821
Query: 335 PLLSNLQELDLSANKKMGSSSENLLSRLRFLPALKSLVINNCAL---ESETFTALAEASV 391
L +L S ++ G+ S +L RL+ C L ++E AL +
Sbjct: 822 AELQRAPDLQESDGQRKGAQSRSLTLRLQ-----------KCQLQVHDAEALIALLQEGP 870
Query: 392 HLSALEVFNLSWNKCVGGNLKLLLETLKLSMSLQVLRLSSCSLVTEDV-ALLASVIQTGH 450
H LE +LS N+ +L+ E + L LS L V +L +V
Sbjct: 871 H---LEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSDNGLSVAGVHCVLRAVSACWT 927
Query: 451 LAKLQKLDLSYNDSICDAGWTMFCQ----------NVRFLKELI-----ELDISLRPSNF 495
LA+L + L + I MF Q FL L+ EL +S R
Sbjct: 928 LAELH-ISLQHKTVI-----FMFAQEPEEQKGPQERAAFLDSLMLQMPSELPLSSRRMRL 981
Query: 496 RDCGQWFRHL 505
CG +HL
Sbjct: 982 THCGLQEKHL 991
Score = 35.4 bits (80), Expect = 0.14
Identities = 44/218 (20%), Positives = 96/218 (44%), Gaps = 42/218 (19%)
Query: 133 SITQQMHLVSKLKILRLGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQ 192
++++ + + +L++L L ++T + L +A + P+L+E++ N
Sbjct: 705 ALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDN------------ 752
Query: 193 KFQKGSKIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLKS 252
Q+ + V ++ ++LP L L LDLS N V +L +A+ +
Sbjct: 753 --------QLSDQVVLNIV--------EVLPHLPRLRKLDLSSNSICVSTLLCLARVAVT 796
Query: 253 TSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRKL-DLSCNKDLGGGFEDSPAQLVMLKH 311
+++L+ L + +L EL++ DL ++ G + + ++ + L+
Sbjct: 797 CPTVRMLQAREADL----IFLLSPPTETTAELQRAPDL---QESDGQRKGAQSRSLTLR- 848
Query: 312 LQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLSANK 349
L +C L D +L ++ +L+E+DLS N+
Sbjct: 849 -----LQKCQLQVHDAEALIALLQEGPHLEEVDLSGNQ 881
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 67.4 bits (163), Expect = 3e-11
Identities = 100/371 (26%), Positives = 154/371 (41%), Gaps = 24/371 (6%)
Query: 115 DLEELDISWNGFVGGTLLSITQQM-HLVSKLKILRLGSCRLTTDDVQALGEAFEMIPELE 173
DL+ DI NG + S+ + + H KL+ LRL SC LT + A L
Sbjct: 735 DLKGSDIGDNG-----VKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALIRSQSLI 789
Query: 174 ELNLSWNSKVGGNLPLILQKFQKGS-KIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLD 232
LNLS N+ + + L+ + + ++ + L C LT +L L + L L
Sbjct: 790 FLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALISNKRLTHLC 849
Query: 233 LSINRDIVGSLNSIAQGLKSTS-NLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSC 291
L+ N G + ++ L+ LK L L C + S + L + + L LDL
Sbjct: 850 LADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHNKSLTHLDLGS 909
Query: 292 NKDLGGGFEDSPAQLV--MLKH----LQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDL 345
N +D+ +L+ + +H LQ L+L C LT + L VI NL+ LDL
Sbjct: 910 N-----WLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLRSLDL 964
Query: 346 SANKKMGSSSENLLSRLRFLPA-LKSLVINNCALESETFTALAEASVHLSALEVFNLSWN 404
N + L LR+ ++ L + C L S L+ A + L NL+ N
Sbjct: 965 GNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMNLTQN 1024
Query: 405 KCVGGNLKLLLETLKL-SMSLQVLRLSSCSLVTEDVALLASV-IQTGHLAKLQKLDLSYN 462
+ L + LK LQVL L + E LL +V + HL + K D +Y+
Sbjct: 1025 TLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHL--IIKPDCNYH 1082
Query: 463 DSICDAGWTMF 473
+ + W F
Sbjct: 1083 NEEDVSWWWCF 1093
>gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Homo
sapiens]
Length = 287
Score = 63.9 bits (154), Expect = 4e-10
Identities = 56/188 (29%), Positives = 96/188 (51%), Gaps = 9/188 (4%)
Query: 93 LNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVG--GTLLSITQQMHLVSKLKILRLG 150
L C ++++ +++ A L +L +D+S NG VG G +L H +L++++L
Sbjct: 32 LKRCRISSSACEDLSAALIANKNLTRMDLSGNG-VGFPGMMLLCEGLRHPQCRLQMIQLR 90
Query: 151 SCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKG-SKIQMIELVDCS 209
C+L + Q + P L EL+L+ N+ L L+ Q + +++ + L C
Sbjct: 91 KCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICR 150
Query: 210 LTSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLN--SIAQGLK-STSNLKVLKLHSCGL 266
LT+ L L + QSL LDLS+N +G L + +GL+ T L+ L+L SCGL
Sbjct: 151 LTAAACDELASTLSVNQSLRELDLSLNE--LGDLGVLLLCEGLRHPTCKLQTLRLDSCGL 208
Query: 267 SQKSVKIL 274
+ K+ + L
Sbjct: 209 TAKACENL 216
Score = 54.3 bits (129), Expect = 3e-07
Identities = 64/228 (28%), Positives = 99/228 (43%), Gaps = 18/228 (7%)
Query: 259 LKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLVMLKH----LQV 314
L L C +S + + L AA L ++DLS N G GF L+H LQ+
Sbjct: 30 LWLKRCRISSSACEDLSAALIANKNLTRMDLSGN---GVGFPGMMLLCEGLRHPQCRLQM 86
Query: 315 LDLHQCSLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLRF-LPALKSLVI 373
+ L +C L + + V+ +L ELDL+ N L LR + L++L +
Sbjct: 87 IQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWL 146
Query: 374 NNCALESETFTALAEASVHLSALEVFNLSWNKCVGGNLKLLLETLK-LSMSLQVLRLSSC 432
C L + LA +L +LS N+ + LL E L+ + LQ LRL SC
Sbjct: 147 KICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSC 206
Query: 433 SLVT---EDVALLASVIQTGHLAKLQKLDLSYNDSICDAGWTMFCQNV 477
L E++ + QT L L L+ N+++ D G + C+ +
Sbjct: 207 GLTAKACENLYFTLGINQT-----LTDLYLT-NNALGDTGVRLLCKRL 248
Score = 50.4 bits (119), Expect = 4e-06
Identities = 64/231 (27%), Positives = 98/231 (42%), Gaps = 6/231 (2%)
Query: 147 LRLGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGS-KIQMIEL 205
L L CR+++ + L A L ++LS N + L+ + + ++QMI+L
Sbjct: 30 LWLKRCRISSSACEDLSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQL 89
Query: 206 VDCSLTSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLKS-TSNLKVLKLHSC 264
C L S + +L L LDL+ N L + QGL+ L+ L L C
Sbjct: 90 RKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKIC 149
Query: 265 GLSQKSVKILDAAFRYLGELRKLDLSCNK--DLGGGFEDSPAQLVMLKHLQVLDLHQCSL 322
L+ + L + LR+LDLS N+ DLG + K LQ L L C L
Sbjct: 150 RLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCK-LQTLRLDSCGL 208
Query: 323 TADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLRFLPALKSLVI 373
TA +L + + L +L L+ N +G + LL + P K V+
Sbjct: 209 TAKACENLYFTLGINQTLTDLYLT-NNALGDTGVRLLCKRLSHPGCKLRVL 258
Score = 49.3 bits (116), Expect = 9e-06
Identities = 44/148 (29%), Positives = 69/148 (46%), Gaps = 2/148 (1%)
Query: 91 LDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVGGTLLSITQQM-HLVSKLKILRL 149
+ L C L + +EM ++L P L ELD++ N L + Q + H V +L+ L L
Sbjct: 87 IQLRKCQLESGACQEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWL 146
Query: 150 GSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGS-KIQMIELVDC 208
CRLT L + L EL+LS N + L+ + + + K+Q + L C
Sbjct: 147 KICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSC 206
Query: 209 SLTSEDGTFLGQLLPMLQSLEVLDLSIN 236
LT++ L L + Q+L L L+ N
Sbjct: 207 GLTAKACENLYFTLGINQTLTDLYLTNN 234
Score = 39.7 bits (91), Expect = 0.007
Identities = 37/124 (29%), Positives = 55/124 (44%), Gaps = 2/124 (1%)
Query: 89 KCLDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVG-GTLLSITQQMHLVSKLKIL 147
+ L L C LT A E+ + L L ELD+S N G LL H KL+ L
Sbjct: 142 RTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTL 201
Query: 148 RLGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKF-QKGSKIQMIELV 206
RL SC LT + L + L +L L+ N+ + L+ ++ G K++++ L
Sbjct: 202 RLDSCGLTAKACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRLSHPGCKLRVLWLF 261
Query: 207 DCSL 210
L
Sbjct: 262 GMDL 265
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 63.2 bits (152), Expect = 6e-10
Identities = 91/313 (29%), Positives = 139/313 (44%), Gaps = 13/313 (4%)
Query: 172 LEELNLSWNSKVGGNLPLILQKFQKGSKIQMIELVDCSLTSEDGTFLGQLLPMLQS---L 228
L EL+LS NSK+ + L K + ++ +L S+T E L L+ LQ L
Sbjct: 728 LHELDLS-NSKLHASSVKGLCLALKNPRCKVQKLTCKSVTPE--WVLQDLIIALQGNSKL 784
Query: 229 EVLDLSINRDIVGSLNSIAQGLK-STSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRKL 287
L+ S N+ + ++ I + L+ S NLK L L C LS S + L + + +L
Sbjct: 785 THLNFSSNK-LGMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRL 843
Query: 288 DLSCNKDLGGGFEDSPAQLVMLK-HLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLS 346
L N+ G + A L K L+ L+L C L A L+ + +L L+LS
Sbjct: 844 CLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLS 903
Query: 347 ANKKMGSSSENLLSRL-RFLPALKSLVINNCALESETFTALAEASVHLSALEVFNLSWNK 405
N + L L R L+SL ++ C+ E LA A H +++ +L N
Sbjct: 904 KNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGEND 963
Query: 406 CVGGNLKLLLETLKLSMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLSYNDSI 465
+KLL E LK +L L L+ C+L T L SV+ + L L+L N+
Sbjct: 964 LQDDGVKLLCEALKPHRALHTLGLAKCNLTTACCQHLFSVLSSS--KSLVNLNLLGNELD 1021
Query: 466 CDAGWTMFCQNVR 478
D G M C+ ++
Sbjct: 1022 TD-GVKMLCKALK 1033
Score = 54.7 bits (130), Expect = 2e-07
Identities = 83/316 (26%), Positives = 131/316 (41%), Gaps = 16/316 (5%)
Query: 115 DLEELDISWNGF----VGGTLLSITQQMHLVSKLKILRLGSCRLTTDD--VQALGEAFEM 168
+L ELD+S + V G L++ V KL +C+ T + +Q L A +
Sbjct: 727 NLHELDLSNSKLHASSVKGLCLALKNPRCKVQKL------TCKSVTPEWVLQDLIIALQG 780
Query: 169 IPELEELNLSWNSKVGGNLPLILQKFQKGS-KIQMIELVDCSLTSEDGTFLGQLLPMLQS 227
+L LN S N K+G +PLIL+ + + ++ + L C+L++ L L +Q
Sbjct: 781 NSKLTHLNFSSN-KLGMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQH 839
Query: 228 LEVLDLSINRDIVGSLNSIAQGLKSTS-NLKVLKLHSCGLSQKSVKILDAAFRYLGELRK 286
+ L L NR + + L L+ L+L C L+ + K L A L
Sbjct: 840 VTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRSLTH 899
Query: 287 LDLSCNKDLGGGFEDSPAQLVMLK-HLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDL 345
L+LS N G + L +LQ L+L CS T + L + N++ LDL
Sbjct: 900 LNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDL 959
Query: 346 SANKKMGSSSENLLSRLRFLPALKSLVINNCALESETFTALAEASVHLSALEVFNLSWNK 405
N + L L+ AL +L + C L + L +L NL N+
Sbjct: 960 GENDLQDDGVKLLCEALKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNE 1019
Query: 406 CVGGNLKLLLETLKLS 421
+K+L + LK S
Sbjct: 1020 LDTDGVKMLCKALKKS 1035
Score = 29.6 bits (65), Expect = 7.5
Identities = 27/120 (22%), Positives = 47/120 (39%), Gaps = 1/120 (0%)
Query: 80 QKLGKKAVN-KCLDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVGGTLLSITQQM 138
+ LG+ N + L+L+ C T E+ L +++ LD+ N + + + +
Sbjct: 917 EALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEAL 976
Query: 139 HLVSKLKILRLGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGS 198
L L L C LTT Q L L LNL N + ++ + +K +
Sbjct: 977 KPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKST 1036
>gi|40788015 caspase recruitment domain protein 12 [Homo sapiens]
Length = 1024
Score = 61.2 bits (147), Expect = 2e-09
Identities = 90/375 (24%), Positives = 149/375 (39%), Gaps = 44/375 (11%)
Query: 153 RLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGSKIQMIELVDCSLTS 212
+L D++ LG+ F L L + + V G+L L+L + I + + LT
Sbjct: 671 KLNKQDIRYLGKIFSSATSLR-LQIKRCAGVAGSLSLVLSTCKN---IYSLMVEASPLTI 726
Query: 213 EDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLKSTSNLKVLKLHSCGLSQKSVK 272
ED + + L++L + DL N+ + G L LK NL L + + ++++
Sbjct: 727 EDERHITSVTN-LKTLSIHDLQ-NQRLPGGLTDSLGNLK---NLTKLIMDNIKMNEEDAI 781
Query: 273 ILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLVMLK-HLQVLDLHQCSLTADDVMSLT 331
L + L ++ L+ D+G G + L L+ + L C L+A+ V L
Sbjct: 782 KLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILA 841
Query: 332 QVIPLLSNLQELDLSAN---KKMGSSSENLLSRLRFLPALKSLVINNCALESETFTALAE 388
Q + L L LDLS N K + L+ R+ L L +L+
Sbjct: 842 QNLHNLVKLSILDLSENYLEKDGNEALHELIDRMNVLEQLTALM---------------- 885
Query: 389 ASVHLSALEVFNLSWNKCVGGNLKLLLETLKLSMSLQVLRLSSCSLVTEDVALLASVIQT 448
L W V G+L LL+ L+ L L L + L ++ +L +
Sbjct: 886 ------------LPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRLTDTEIRILGAFFGK 933
Query: 449 GHLAKLQKLDLSYNDSICDAGWTMFCQNVRFLKELIELDISLRPSNFRDCGQWFRHLLYA 508
L Q+L+L+ N + GW F LK+L+ D S + F R L
Sbjct: 934 NPLKNFQQLNLAGN-RVSSDGWLAFMGVFENLKQLVFFDFSTK--EFLPDPALVRKLSQV 990
Query: 509 VTKLPQITEIGMKRW 523
++KL + E + W
Sbjct: 991 LSKLTFLQEARLVGW 1005
Score = 51.2 bits (121), Expect = 2e-06
Identities = 65/262 (24%), Positives = 113/262 (43%), Gaps = 13/262 (4%)
Query: 279 RYLGELRKLDLSCN---KDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIP 335
RYLG++ S K G L K++ L + LT +D +T V
Sbjct: 678 RYLGKIFSSATSLRLQIKRCAGVAGSLSLVLSTCKNIYSLMVEASPLTIEDERHITSVTN 737
Query: 336 LLSNLQELDLSANKKMGSSSENLLSRLRFLPALKSLVINNCALESETFTALAEASVHLSA 395
L L DL + G +++L + L L L+++N + E LAE +L
Sbjct: 738 L-KTLSIHDLQNQRLPGGLTDSLGN----LKNLTKLIMDNIKMNEEDAIKLAEGLKNLKK 792
Query: 396 LEVFNLSWNKCVGGNLKLLLETLKLS-MSLQVLRLSSCSLVTEDVALLASVIQTGHLAKL 454
+ +F+L+ +G + ++++L L+ ++L SC L V +LA + +L KL
Sbjct: 793 MCLFHLTHLSDIGEGMDYIVKSLSSEPCDLEEIQLVSCCLSANAVKILAQNLH--NLVKL 850
Query: 455 QKLDLSYNDSICDAGWTMFCQNVRFLKELIELDISLRPSNFRDCGQWFRHLLYAVTKLPQ 514
LDLS N D + + + + L +L + P G LL + ++PQ
Sbjct: 851 SILDLSENYLEKDGNEALH-ELIDRMNVLEQLTALMLPWGCDVQGS-LSSLLKHLEEVPQ 908
Query: 515 ITEIGMKRWILPASQEEELECF 536
+ ++G+K W L ++ L F
Sbjct: 909 LVKLGLKNWRLTDTEIRILGAF 930
Score = 49.3 bits (116), Expect = 9e-06
Identities = 58/248 (23%), Positives = 101/248 (40%), Gaps = 36/248 (14%)
Query: 134 ITQQMHLVSKLKILRLGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQK 193
+T + + L L + + ++ +D L E + + ++ +L+ S +G + I++
Sbjct: 755 LTDSLGNLKNLTKLIMDNIKMNEEDAIKLAEGLKNLKKMCLFHLTHLSDIGEGMDYIVKS 814
Query: 194 FQ-KGSKIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLDLSINR--------------- 237
+ ++ I+LV C L++ L Q L L L +LDLS N
Sbjct: 815 LSSEPCDLEEIQLVSCCLSANAVKILAQNLHNLVKLSILDLSENYLEKDGNEALHELIDR 874
Query: 238 ----------------DIVGSLNSIAQGLKSTSNLKVLKLHSCGLSQKSVKILDAAF--R 279
D+ GSL+S+ + L+ L L L + L+ ++IL A F
Sbjct: 875 MNVLEQLTALMLPWGCDVQGSLSSLLKHLEEVPQLVKLGLKNWRLTDTEIRILGAFFGKN 934
Query: 280 YLGELRKLDLSCNKDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTADD--VMSLTQVIPLL 337
L ++L+L+ N+ G+ LK L D D V L+QV+ L
Sbjct: 935 PLKNFQQLNLAGNRVSSDGWLAFMGVFENLKQLVFFDFSTKEFLPDPALVRKLSQVLSKL 994
Query: 338 SNLQELDL 345
+ LQE L
Sbjct: 995 TFLQEARL 1002
Score = 39.7 bits (91), Expect = 0.007
Identities = 31/113 (27%), Positives = 55/113 (48%), Gaps = 18/113 (15%)
Query: 70 SSMEKNEHFLQKLGKKAVNKCLDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVGG 129
S ++ +E++L+K G +A+++ +D N L L L + W V G
Sbjct: 851 SILDLSENYLEKDGNEALHELIDRMNV----------------LEQLTALMLPWGCDVQG 894
Query: 130 TLLSITQQMHLVSKLKILRLGSCRLTTDDVQALGEAFEMIP--ELEELNLSWN 180
+L S+ + + V +L L L + RLT +++ LG F P ++LNL+ N
Sbjct: 895 SLSSLLKHLEEVPQLVKLGLKNWRLTDTEIRILGAFFGKNPLKNFQQLNLAGN 947
>gi|7662386 NLR family, pyrin domain containing 1 isoform 2 [Homo
sapiens]
Length = 1429
Score = 59.7 bits (143), Expect = 7e-09
Identities = 53/177 (29%), Positives = 87/177 (49%), Gaps = 8/177 (4%)
Query: 98 LTTADMKEMVALLPFLPDLEELDISWNGFVGGTLLSITQQMHLVS-KLKILRLGSCRLTT 156
+T A + + ++L +L+ELD+S N + S+ + + L+ LRL C LT
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 157 DDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGS-KIQMIELVDCSLTSEDG 215
+D + L L EL+LS+N + Q+ ++ S K+Q ++LV C LTS+
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 216 TFLGQLLPMLQSLEVLDLSINR-DIVGSLNSIAQGLKSTSNLKVLKLHSCGLSQKSV 271
L +L SL+ LDL N D VG + + +GL+ + KL GL Q ++
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVG-VRLLCEGLRHPA----CKLIRLGLDQTTL 963
Score = 57.4 bits (137), Expect = 3e-08
Identities = 54/179 (30%), Positives = 84/179 (46%), Gaps = 13/179 (7%)
Query: 302 SPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSR 361
SP +V+ + + V D + L V+ + NL+ELDLS N S+ ++L
Sbjct: 780 SPTMVVLFRWVPVTDAYW--------QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKT 831
Query: 362 LRFLPAL-KSLVINNCALESETFTALAEASVHLSALEVFNLSWNKCVGGNLKLLLETLKL 420
LR L ++L + C L +E LA L +LS+N K L + L+
Sbjct: 832 LRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQ 891
Query: 421 -SMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLSYNDSICDAGWTMFCQNVR 478
S LQ L+L SC L ++ LASV+ L++LDL N ++ D G + C+ +R
Sbjct: 892 PSCKLQRLQLVSCGLTSDCCQDLASVLSAS--PSLKELDLQQN-NLDDVGVRLLCEGLR 947
Score = 50.8 bits (120), Expect = 3e-06
Identities = 59/199 (29%), Positives = 93/199 (46%), Gaps = 17/199 (8%)
Query: 91 LDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVGGTLLSITQQMHLVS-KLKILRL 149
L L CGLT D K++ L L ELD+S+N + Q++ S KL+ L+L
Sbjct: 842 LRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQL 901
Query: 150 GSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQ-KGSKIQMIELVDC 208
SC LT+D Q L P L+EL+L N+ + L+ + + K+ + L
Sbjct: 902 VSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQT 961
Query: 209 SLTSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGL------KSTSNLKVLKLH 262
+L+ E + Q L L+ E L I S+ + +GL STS+LK +L
Sbjct: 962 TLSDE----MRQELRALEQ-EKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLG 1016
Query: 263 S----CGLSQKSVKILDAA 277
S ++Q ++K+LD +
Sbjct: 1017 SERAASHVAQANLKLLDVS 1035
Score = 48.9 bits (115), Expect = 1e-05
Identities = 43/133 (32%), Positives = 64/133 (48%), Gaps = 2/133 (1%)
Query: 218 LGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLKSTSNL-KVLKLHSCGLSQKSVKILDA 276
L +L + ++L+ LDLS N ++ S+ + L+ L + L+L CGL+ + K L
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 277 AFRYLGELRKLDLSCNKDLGGGFEDSPAQLVMLK-HLQVLDLHQCSLTADDVMSLTQVIP 335
R L +LDLS N G + +L LQ L L C LT+D L V+
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 336 LLSNLQELDLSAN 348
+L+ELDL N
Sbjct: 920 ASPSLKELDLQQN 932
Score = 43.9 bits (102), Expect = 4e-04
Identities = 51/172 (29%), Positives = 70/172 (40%), Gaps = 30/172 (17%)
Query: 250 LKSTSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLVML 309
LK T NLK L L LS +VK L R P L
Sbjct: 804 LKVTRNLKELDLSGNSLSHSAVKSLCKTLR----------------------RPRCL--- 838
Query: 310 KHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLRFLPA-- 367
L+ L L C LTA+D L + L ELDLS N + +++L RLR P+
Sbjct: 839 --LETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLR-QPSCK 895
Query: 368 LKSLVINNCALESETFTALAEASVHLSALEVFNLSWNKCVGGNLKLLLETLK 419
L+ L + +C L S+ LA +L+ +L N ++LL E L+
Sbjct: 896 LQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLR 947
>gi|74271814 NLR family, pyrin domain containing 1 isoform 5 [Homo
sapiens]
Length = 1375
Score = 59.7 bits (143), Expect = 7e-09
Identities = 53/177 (29%), Positives = 87/177 (49%), Gaps = 8/177 (4%)
Query: 98 LTTADMKEMVALLPFLPDLEELDISWNGFVGGTLLSITQQMHLVS-KLKILRLGSCRLTT 156
+T A + + ++L +L+ELD+S N + S+ + + L+ LRL C LT
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 157 DDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGS-KIQMIELVDCSLTSEDG 215
+D + L L EL+LS+N + Q+ ++ S K+Q ++LV C LTS+
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 216 TFLGQLLPMLQSLEVLDLSINR-DIVGSLNSIAQGLKSTSNLKVLKLHSCGLSQKSV 271
L +L SL+ LDL N D VG + + +GL+ + KL GL Q ++
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVG-VRLLCEGLRHPA----CKLIRLGLDQTTL 963
Score = 57.4 bits (137), Expect = 3e-08
Identities = 54/179 (30%), Positives = 84/179 (46%), Gaps = 13/179 (7%)
Query: 302 SPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSR 361
SP +V+ + + V D + L V+ + NL+ELDLS N S+ ++L
Sbjct: 780 SPTMVVLFRWVPVTDAYW--------QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKT 831
Query: 362 LRFLPAL-KSLVINNCALESETFTALAEASVHLSALEVFNLSWNKCVGGNLKLLLETLKL 420
LR L ++L + C L +E LA L +LS+N K L + L+
Sbjct: 832 LRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQ 891
Query: 421 -SMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLSYNDSICDAGWTMFCQNVR 478
S LQ L+L SC L ++ LASV+ L++LDL N ++ D G + C+ +R
Sbjct: 892 PSCKLQRLQLVSCGLTSDCCQDLASVLSAS--PSLKELDLQQN-NLDDVGVRLLCEGLR 947
Score = 50.8 bits (120), Expect = 3e-06
Identities = 59/199 (29%), Positives = 93/199 (46%), Gaps = 17/199 (8%)
Query: 91 LDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVGGTLLSITQQMHLVS-KLKILRL 149
L L CGLT D K++ L L ELD+S+N + Q++ S KL+ L+L
Sbjct: 842 LRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQL 901
Query: 150 GSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQ-KGSKIQMIELVDC 208
SC LT+D Q L P L+EL+L N+ + L+ + + K+ + L
Sbjct: 902 VSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQT 961
Query: 209 SLTSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGL------KSTSNLKVLKLH 262
+L+ E + Q L L+ E L I S+ + +GL STS+LK +L
Sbjct: 962 TLSDE----MRQELRALEQ-EKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLG 1016
Query: 263 S----CGLSQKSVKILDAA 277
S ++Q ++K+LD +
Sbjct: 1017 SERAASHVAQANLKLLDVS 1035
Score = 48.9 bits (115), Expect = 1e-05
Identities = 43/133 (32%), Positives = 64/133 (48%), Gaps = 2/133 (1%)
Query: 218 LGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLKSTSNL-KVLKLHSCGLSQKSVKILDA 276
L +L + ++L+ LDLS N ++ S+ + L+ L + L+L CGL+ + K L
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 277 AFRYLGELRKLDLSCNKDLGGGFEDSPAQLVMLK-HLQVLDLHQCSLTADDVMSLTQVIP 335
R L +LDLS N G + +L LQ L L C LT+D L V+
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 336 LLSNLQELDLSAN 348
+L+ELDL N
Sbjct: 920 ASPSLKELDLQQN 932
Score = 43.9 bits (102), Expect = 4e-04
Identities = 51/172 (29%), Positives = 70/172 (40%), Gaps = 30/172 (17%)
Query: 250 LKSTSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLVML 309
LK T NLK L L LS +VK L R P L
Sbjct: 804 LKVTRNLKELDLSGNSLSHSAVKSLCKTLR----------------------RPRCL--- 838
Query: 310 KHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLRFLPA-- 367
L+ L L C LTA+D L + L ELDLS N + +++L RLR P+
Sbjct: 839 --LETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLR-QPSCK 895
Query: 368 LKSLVINNCALESETFTALAEASVHLSALEVFNLSWNKCVGGNLKLLLETLK 419
L+ L + +C L S+ LA +L+ +L N ++LL E L+
Sbjct: 896 LQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLR 947
>gi|14719829 NLR family, pyrin domain containing 1 isoform 1 [Homo
sapiens]
Length = 1473
Score = 59.7 bits (143), Expect = 7e-09
Identities = 53/177 (29%), Positives = 87/177 (49%), Gaps = 8/177 (4%)
Query: 98 LTTADMKEMVALLPFLPDLEELDISWNGFVGGTLLSITQQMHLVS-KLKILRLGSCRLTT 156
+T A + + ++L +L+ELD+S N + S+ + + L+ LRL C LT
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 157 DDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGS-KIQMIELVDCSLTSEDG 215
+D + L L EL+LS+N + Q+ ++ S K+Q ++LV C LTS+
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 216 TFLGQLLPMLQSLEVLDLSINR-DIVGSLNSIAQGLKSTSNLKVLKLHSCGLSQKSV 271
L +L SL+ LDL N D VG + + +GL+ + KL GL Q ++
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVG-VRLLCEGLRHPA----CKLIRLGLDQTTL 963
Score = 57.4 bits (137), Expect = 3e-08
Identities = 54/179 (30%), Positives = 84/179 (46%), Gaps = 13/179 (7%)
Query: 302 SPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSR 361
SP +V+ + + V D + L V+ + NL+ELDLS N S+ ++L
Sbjct: 780 SPTMVVLFRWVPVTDAYW--------QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKT 831
Query: 362 LRFLPAL-KSLVINNCALESETFTALAEASVHLSALEVFNLSWNKCVGGNLKLLLETLKL 420
LR L ++L + C L +E LA L +LS+N K L + L+
Sbjct: 832 LRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQ 891
Query: 421 -SMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLSYNDSICDAGWTMFCQNVR 478
S LQ L+L SC L ++ LASV+ L++LDL N ++ D G + C+ +R
Sbjct: 892 PSCKLQRLQLVSCGLTSDCCQDLASVLSAS--PSLKELDLQQN-NLDDVGVRLLCEGLR 947
Score = 50.8 bits (120), Expect = 3e-06
Identities = 59/199 (29%), Positives = 93/199 (46%), Gaps = 17/199 (8%)
Query: 91 LDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVGGTLLSITQQMHLVS-KLKILRL 149
L L CGLT D K++ L L ELD+S+N + Q++ S KL+ L+L
Sbjct: 842 LRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQL 901
Query: 150 GSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQ-KGSKIQMIELVDC 208
SC LT+D Q L P L+EL+L N+ + L+ + + K+ + L
Sbjct: 902 VSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLRHPACKLIRLGLDQT 961
Query: 209 SLTSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGL------KSTSNLKVLKLH 262
+L+ E + Q L L+ E L I S+ + +GL STS+LK +L
Sbjct: 962 TLSDE----MRQELRALEQ-EKPQLLIFSRRKPSVMTPTEGLDTGEMSNSTSSLKRQRLG 1016
Query: 263 S----CGLSQKSVKILDAA 277
S ++Q ++K+LD +
Sbjct: 1017 SERAASHVAQANLKLLDVS 1035
Score = 48.9 bits (115), Expect = 1e-05
Identities = 43/133 (32%), Positives = 64/133 (48%), Gaps = 2/133 (1%)
Query: 218 LGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLKSTSNL-KVLKLHSCGLSQKSVKILDA 276
L +L + ++L+ LDLS N ++ S+ + L+ L + L+L CGL+ + K L
Sbjct: 800 LFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDLAF 859
Query: 277 AFRYLGELRKLDLSCNKDLGGGFEDSPAQLVMLK-HLQVLDLHQCSLTADDVMSLTQVIP 335
R L +LDLS N G + +L LQ L L C LT+D L V+
Sbjct: 860 GLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASVLS 919
Query: 336 LLSNLQELDLSAN 348
+L+ELDL N
Sbjct: 920 ASPSLKELDLQQN 932
Score = 43.9 bits (102), Expect = 4e-04
Identities = 51/172 (29%), Positives = 70/172 (40%), Gaps = 30/172 (17%)
Query: 250 LKSTSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLVML 309
LK T NLK L L LS +VK L R P L
Sbjct: 804 LKVTRNLKELDLSGNSLSHSAVKSLCKTLR----------------------RPRCL--- 838
Query: 310 KHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLRFLPA-- 367
L+ L L C LTA+D L + L ELDLS N + +++L RLR P+
Sbjct: 839 --LETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLR-QPSCK 895
Query: 368 LKSLVINNCALESETFTALAEASVHLSALEVFNLSWNKCVGGNLKLLLETLK 419
L+ L + +C L S+ LA +L+ +L N ++LL E L+
Sbjct: 896 LQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLR 947
>gi|194018482 NLR family, pyrin domain containing 4 [Homo sapiens]
Length = 994
Score = 59.3 bits (142), Expect = 9e-09
Identities = 78/337 (23%), Positives = 139/337 (41%), Gaps = 37/337 (10%)
Query: 33 RKEDNDLKTSDSQPSDW------------IQKTATSETAKPLSSEMEWRSSMEKNEHFLQ 80
+KED TSD W +++ ++ S+ + W + + LQ
Sbjct: 611 KKEDEHSSTSDYSLICWHHICSVLTTSGHLRELQVQDSTLSESTFVTWCNQLRHPSCRLQ 670
Query: 81 KLGKKAVNKCLDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVGGTLLSITQQMHL 140
KLG +NN + + + +L + PDL+ L + + S+ ++
Sbjct: 671 KLG---------INNVSFSGQSVL-LFEVLFYQPDLKYLSFTLTKLSRDDIRSLCDALNY 720
Query: 141 -VSKLKILRLGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGSK 199
+K L L +C L+ D + L +L LN+S N G +PL+ +
Sbjct: 721 PAGNVKELALVNCHLSPIDCEVLAGLLTNNKKLTYLNVSCNQLDTG-VPLLCEALCSPDT 779
Query: 200 IQM-IELVDCSLTSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLKSTSN-LK 257
+ + + L C L+ + ++ ++L +S+ LDLS N L ++ + LK L
Sbjct: 780 VLVYLMLAFCHLSEQCCEYISEMLLRNKSVRYLDLSANVLKDEGLKTLCEALKHPDCCLD 839
Query: 258 VLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLVM--LKH---- 311
L L C ++ + L +A L+ L + CN+ D QL+ L H
Sbjct: 840 SLCLVKCFITAAGCEDLASALISNQNLKILQIGCNE-----IGDVGVQLLCRALTHTDCR 894
Query: 312 LQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLSAN 348
L++L L +C LT+ L V+ LQ+L+L+ N
Sbjct: 895 LEILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLN 931
Score = 34.3 bits (77), Expect = 0.31
Identities = 31/97 (31%), Positives = 46/97 (47%), Gaps = 6/97 (6%)
Query: 90 CLD---LNNCGLTTADMKEMVALLPFLPDLEELDISWN--GFVGGTLLSITQQMHLVSKL 144
CLD L C +T A +++ + L +L+ L I N G VG LL H +L
Sbjct: 837 CLDSLCLVKCFITAAGCEDLASALISNQNLKILQIGCNEIGDVGVQLLC-RALTHTDCRL 895
Query: 145 KILRLGSCRLTTDDVQALGEAFEMIPELEELNLSWNS 181
+IL L C LT+ + L L++LNL+ N+
Sbjct: 896 EILGLEECGLTSTCCKDLASVLTCSKTLQQLNLTLNT 932
>gi|14719835 NLR family, pyrin domain containing 1 isoform 4 [Homo
sapiens]
Length = 1399
Score = 58.5 bits (140), Expect = 2e-08
Identities = 48/157 (30%), Positives = 79/157 (50%), Gaps = 4/157 (2%)
Query: 98 LTTADMKEMVALLPFLPDLEELDISWNGFVGGTLLSITQQMHLVS-KLKILRLGSCRLTT 156
+T A + + ++L +L+ELD+S N + S+ + + L+ LRL C LT
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 157 DDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGS-KIQMIELVDCSLTSEDG 215
+D + L L EL+LS+N + Q+ ++ S K+Q ++LV C LTS+
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 216 TFLGQLLPMLQSLEVLDLSINR-DIVGSLNSIAQGLK 251
L +L SL+ LDL N D VG + + +GL+
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVG-VRLLCEGLR 947
Score = 57.4 bits (137), Expect = 3e-08
Identities = 54/179 (30%), Positives = 84/179 (46%), Gaps = 13/179 (7%)
Query: 302 SPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSR 361
SP +V+ + + V D + L V+ + NL+ELDLS N S+ ++L
Sbjct: 780 SPTMVVLFRWVPVTDAYW--------QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKT 831
Query: 362 LRFLPAL-KSLVINNCALESETFTALAEASVHLSALEVFNLSWNKCVGGNLKLLLETLKL 420
LR L ++L + C L +E LA L +LS+N K L + L+
Sbjct: 832 LRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQ 891
Query: 421 -SMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLSYNDSICDAGWTMFCQNVR 478
S LQ L+L SC L ++ LASV+ L++LDL N ++ D G + C+ +R
Sbjct: 892 PSCKLQRLQLVSCGLTSDCCQDLASVLSAS--PSLKELDLQQN-NLDDVGVRLLCEGLR 947
Score = 50.4 bits (119), Expect = 4e-06
Identities = 34/92 (36%), Positives = 47/92 (51%), Gaps = 1/92 (1%)
Query: 91 LDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVGGTLLSITQQMHLVS-KLKILRL 149
L L CGLT D K++ L L ELD+S+N + Q++ S KL+ L+L
Sbjct: 842 LRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQL 901
Query: 150 GSCRLTTDDVQALGEAFEMIPELEELNLSWNS 181
SC LT+D Q L P L+EL+L N+
Sbjct: 902 VSCGLTSDCCQDLASVLSASPSLKELDLQQNN 933
Score = 46.2 bits (108), Expect = 8e-05
Identities = 55/189 (29%), Positives = 80/189 (42%), Gaps = 31/189 (16%)
Query: 250 LKSTSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLVML 309
LK T NLK L L LS +VK L R P L
Sbjct: 804 LKVTRNLKELDLSGNSLSHSAVKSLCKTLR----------------------RPRCL--- 838
Query: 310 KHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLRFLPA-- 367
L+ L L C LTA+D L + L ELDLS N + +++L RLR P+
Sbjct: 839 --LETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLR-QPSCK 895
Query: 368 LKSLVINNCALESETFTALAEASVHLSALEVFNLSWNKCVGGNLKLLLETLKLSMSLQVL 427
L+ L + +C L S+ LA +L+ +L N ++LL E L+ + +++
Sbjct: 896 LQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLR-HPACKLI 954
Query: 428 RLSSCSLVT 436
RL S++T
Sbjct: 955 RLGKPSVMT 963
Score = 45.1 bits (105), Expect = 2e-04
Identities = 40/135 (29%), Positives = 63/135 (46%), Gaps = 2/135 (1%)
Query: 160 QALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGS-KIQMIELVDCSLTSEDGTFL 218
Q L ++ L+EL+LS NS + + + ++ ++ + L C LT+ED L
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 219 GQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLKSTS-NLKVLKLHSCGLSQKSVKILDAA 277
L Q+L LDLS N + Q L+ S L+ L+L SCGL+ + L +
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 278 FRYLGELRKLDLSCN 292
L++LDL N
Sbjct: 918 LSASPSLKELDLQQN 932
>gi|14719833 NLR family, pyrin domain containing 1 isoform 3 [Homo
sapiens]
Length = 1443
Score = 58.5 bits (140), Expect = 2e-08
Identities = 48/157 (30%), Positives = 79/157 (50%), Gaps = 4/157 (2%)
Query: 98 LTTADMKEMVALLPFLPDLEELDISWNGFVGGTLLSITQQMHLVS-KLKILRLGSCRLTT 156
+T A + + ++L +L+ELD+S N + S+ + + L+ LRL C LT
Sbjct: 792 VTDAYWQILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTA 851
Query: 157 DDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGS-KIQMIELVDCSLTSEDG 215
+D + L L EL+LS+N + Q+ ++ S K+Q ++LV C LTS+
Sbjct: 852 EDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCC 911
Query: 216 TFLGQLLPMLQSLEVLDLSINR-DIVGSLNSIAQGLK 251
L +L SL+ LDL N D VG + + +GL+
Sbjct: 912 QDLASVLSASPSLKELDLQQNNLDDVG-VRLLCEGLR 947
Score = 57.4 bits (137), Expect = 3e-08
Identities = 54/179 (30%), Positives = 84/179 (46%), Gaps = 13/179 (7%)
Query: 302 SPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSR 361
SP +V+ + + V D + L V+ + NL+ELDLS N S+ ++L
Sbjct: 780 SPTMVVLFRWVPVTDAYW--------QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKT 831
Query: 362 LRFLPAL-KSLVINNCALESETFTALAEASVHLSALEVFNLSWNKCVGGNLKLLLETLKL 420
LR L ++L + C L +E LA L +LS+N K L + L+
Sbjct: 832 LRRPRCLLETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQ 891
Query: 421 -SMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLSYNDSICDAGWTMFCQNVR 478
S LQ L+L SC L ++ LASV+ L++LDL N ++ D G + C+ +R
Sbjct: 892 PSCKLQRLQLVSCGLTSDCCQDLASVLSAS--PSLKELDLQQN-NLDDVGVRLLCEGLR 947
Score = 50.4 bits (119), Expect = 4e-06
Identities = 34/92 (36%), Positives = 47/92 (51%), Gaps = 1/92 (1%)
Query: 91 LDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVGGTLLSITQQMHLVS-KLKILRL 149
L L CGLT D K++ L L ELD+S+N + Q++ S KL+ L+L
Sbjct: 842 LRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQL 901
Query: 150 GSCRLTTDDVQALGEAFEMIPELEELNLSWNS 181
SC LT+D Q L P L+EL+L N+
Sbjct: 902 VSCGLTSDCCQDLASVLSASPSLKELDLQQNN 933
Score = 46.2 bits (108), Expect = 8e-05
Identities = 55/189 (29%), Positives = 80/189 (42%), Gaps = 31/189 (16%)
Query: 250 LKSTSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLVML 309
LK T NLK L L LS +VK L R P L
Sbjct: 804 LKVTRNLKELDLSGNSLSHSAVKSLCKTLR----------------------RPRCL--- 838
Query: 310 KHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLRFLPA-- 367
L+ L L C LTA+D L + L ELDLS N + +++L RLR P+
Sbjct: 839 --LETLRLAGCGLTAEDCKDLAFGLRANQTLTELDLSFNVLTDAGAKHLCQRLR-QPSCK 895
Query: 368 LKSLVINNCALESETFTALAEASVHLSALEVFNLSWNKCVGGNLKLLLETLKLSMSLQVL 427
L+ L + +C L S+ LA +L+ +L N ++LL E L+ + +++
Sbjct: 896 LQRLQLVSCGLTSDCCQDLASVLSASPSLKELDLQQNNLDDVGVRLLCEGLR-HPACKLI 954
Query: 428 RLSSCSLVT 436
RL S++T
Sbjct: 955 RLGKPSVMT 963
Score = 45.1 bits (105), Expect = 2e-04
Identities = 40/135 (29%), Positives = 63/135 (46%), Gaps = 2/135 (1%)
Query: 160 QALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGS-KIQMIELVDCSLTSEDGTFL 218
Q L ++ L+EL+LS NS + + + ++ ++ + L C LT+ED L
Sbjct: 798 QILFSVLKVTRNLKELDLSGNSLSHSAVKSLCKTLRRPRCLLETLRLAGCGLTAEDCKDL 857
Query: 219 GQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLKSTS-NLKVLKLHSCGLSQKSVKILDAA 277
L Q+L LDLS N + Q L+ S L+ L+L SCGL+ + L +
Sbjct: 858 AFGLRANQTLTELDLSFNVLTDAGAKHLCQRLRQPSCKLQRLQLVSCGLTSDCCQDLASV 917
Query: 278 FRYLGELRKLDLSCN 292
L++LDL N
Sbjct: 918 LSASPSLKELDLQQN 932
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 56.2 bits (134), Expect = 8e-08
Identities = 83/298 (27%), Positives = 128/298 (42%), Gaps = 19/298 (6%)
Query: 144 LKILRLGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVG-GNLPLILQKFQKGSKIQM 202
L+ LRL C LT + + P L+ L+L+ N G +PL +Q
Sbjct: 868 LESLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQK 927
Query: 203 IELVDCSLTSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLKSTS-NLKVLKL 261
+ L DC +T+ L L +SL L LS N +N + + ++ +L+ L L
Sbjct: 928 LILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLML 987
Query: 262 HSCGLSQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQL---VMLK---HLQVL 315
+ C L L A L L LS N ED+ +L VM + HLQ L
Sbjct: 988 NQCHLDTAGCGFLALALMGNSWLTHLSLSMNP-----VEDNGVKLLCEVMREPSCHLQDL 1042
Query: 316 DLHQCSLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLRFL-PALKSLVIN 374
+L +C LTA SL+ VI +L+ LDL+ N L L+ L L +
Sbjct: 1043 ELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLK 1102
Query: 375 NCALESETFTALAEA---SVHLSALEVFNLSWNKCVGGNLKLLLETLKLSMSLQVLRL 429
C L S+ AL+ A + HL++L + +++ G +KL + +LQ++ L
Sbjct: 1103 ACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSP--KGMMKLCSAFACPTSNLQIIGL 1158
Score = 55.1 bits (131), Expect = 2e-07
Identities = 68/269 (25%), Positives = 116/269 (43%), Gaps = 6/269 (2%)
Query: 85 KAVNKCLDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVGGTLLSITQQMHLVS-K 143
K + + L L+ CGLT A ++ +L P L+ L ++ N ++ ++ + +
Sbjct: 865 KCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCA 924
Query: 144 LKILRLGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQ-KGSKIQM 202
L+ L L C +T Q+L A L L LS NS + L+ + + +Q
Sbjct: 925 LQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQR 984
Query: 203 IELVDCSLTSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLKSTS-NLKVLKL 261
+ L C L + FL L L L LS+N + + + ++ S +L+ L+L
Sbjct: 985 LMLNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLEL 1044
Query: 262 HSCGLSQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLVMLKH--LQVLDLHQ 319
C L+ + L L+ LDL+ N LG G + + + K+ L L L
Sbjct: 1045 VKCHLTAACCESLSCVISRSRHLKSLDLTDNA-LGDGGVAALCEGLKQKNSVLARLGLKA 1103
Query: 320 CSLTADDVMSLTQVIPLLSNLQELDLSAN 348
C LT+D +L+ + +L L+L N
Sbjct: 1104 CGLTSDCCEALSLALSCNRHLTSLNLVQN 1132
Score = 33.9 bits (76), Expect = 0.40
Identities = 27/92 (29%), Positives = 44/92 (47%), Gaps = 1/92 (1%)
Query: 91 LDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVGGTLLSITQQMHLV-SKLKILRL 149
L+L C LT A + + ++ L+ LD++ N G + ++ + + S L L L
Sbjct: 1042 LELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGL 1101
Query: 150 GSCRLTTDDVQALGEAFEMIPELEELNLSWNS 181
+C LT+D +AL A L LNL N+
Sbjct: 1102 KACGLTSDCCEALSLALSCNRHLTSLNLVQNN 1133
>gi|4506411 Ran GTPase activating protein 1 [Homo sapiens]
Length = 587
Score = 55.8 bits (133), Expect = 1e-07
Identities = 44/153 (28%), Positives = 71/153 (46%), Gaps = 7/153 (4%)
Query: 144 LKILRLGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGSKIQMI 203
LK+ G RL D AL EAF +I LEE+++ N + + Q F +++I
Sbjct: 182 LKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVI 241
Query: 204 ELVDCSLTSEDGTFLGQLLPMLQSLEVLD----LSINRDIVGSLNSIAQGLKSTSNLKVL 259
L D + T + + + L L+ +EV++ L ++ V ++I GL LK L
Sbjct: 242 NLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGL---PKLKEL 298
Query: 260 KLHSCGLSQKSVKILDAAFRYLGELRKLDLSCN 292
L C + + + + A EL KLDL+ N
Sbjct: 299 NLSFCEIKRDAALAVAEAMADKAELEKLDLNGN 331
Score = 46.6 bits (109), Expect = 6e-05
Identities = 79/312 (25%), Positives = 122/312 (39%), Gaps = 27/312 (8%)
Query: 211 TSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLKSTSNLKVLKLHSCGLSQKS 270
T+ED + + + SLE L L N V + IA+ L+ S LK +
Sbjct: 34 TAEDAKDVIKEIEDFDSLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLR 93
Query: 271 VKILDAAFRYLGE--------LRKLDLSCNKDLGGGFEDSPAQLVMLK--HLQVLDLHQC 320
+I A LGE L +LDLS N G + A L LQ L L+ C
Sbjct: 94 TEIPPALIS-LGEGLITAGAQLVELDLSDNAFGPDGVQGFEALLKSSACFTLQELKLNNC 152
Query: 321 ------------SLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLRFLPAL 368
+LT S Q PL L+ N+ + L R + L
Sbjct: 153 GMGIGGGKILAAALTECHRKSSAQGKPLA--LKVFVAGRNRLENDGATALAEAFRVIGTL 210
Query: 369 KSLVINNCALESETFTALAEASVHLSALEVFNLSWNKCVGGNLKLLLETLKLSMSLQVLR 428
+ + + + TALA+A L V NL+ N + ETLK ++V+
Sbjct: 211 EEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVIN 270
Query: 429 LSSCSLVTEDVALLASVIQTGHLAKLQKLDLSYNDSICDAGWTMFCQNVRFLKELIELDI 488
C + ++ +A I+ G L KL++L+LS+ + DA + + + EL +LD+
Sbjct: 271 FGDCLVRSKGAVAIADAIR-GGLPKLKELNLSFCEIKRDAALAV-AEAMADKAELEKLDL 328
Query: 489 SLRPSNFRDCGQ 500
+ C Q
Sbjct: 329 NGNTLGEEGCEQ 340
Score = 37.0 bits (84), Expect = 0.047
Identities = 39/198 (19%), Positives = 82/198 (41%), Gaps = 17/198 (8%)
Query: 91 LDLNNCGLTTADMKEMVALLPFL---PDLEELDISWNGFVGGT-------LLSITQQMHL 140
L LNNCG+ K + A L + ++ FV G ++ + +
Sbjct: 147 LKLNNCGMGIGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFRV 206
Query: 141 VSKLKILRLGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGSKI 200
+ L+ + + + + AL +AF + P L +NL+ N+ + + + ++
Sbjct: 207 IGTLEEVHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQV 266
Query: 201 QMIELVDCSLTSEDGTFLGQL----LPMLQSLEVLDLSINRDIVGSLNSIAQGLKSTSNL 256
++I DC + S+ + LP L+ L + I RD + ++A+ + + L
Sbjct: 267 EVINFGDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEIKRD---AALAVAEAMADKAEL 323
Query: 257 KVLKLHSCGLSQKSVKIL 274
+ L L+ L ++ + L
Sbjct: 324 EKLDLNGNTLGEEGCEQL 341
Score = 30.0 bits (66), Expect = 5.8
Identities = 29/100 (29%), Positives = 43/100 (43%), Gaps = 4/100 (4%)
Query: 86 AVNKCLDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFV----GGTLLSITQQMHLV 141
AVN L + N T K VA+ L L ++++ G G + +
Sbjct: 233 AVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGL 292
Query: 142 SKLKILRLGSCRLTTDDVQALGEAFEMIPELEELNLSWNS 181
KLK L L C + D A+ EA ELE+L+L+ N+
Sbjct: 293 PKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNT 332
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 54.7 bits (130), Expect = 2e-07
Identities = 94/351 (26%), Positives = 145/351 (41%), Gaps = 56/351 (15%)
Query: 113 LPDLEELDISWNGFVGGTLLSITQQMHLVSKLKILRLGSCRLTTDDVQALGEAFEMIPEL 172
LP + +D+S N F GG + M + LK+ R G C L E + +L
Sbjct: 7 LPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLP--------EELAALQKL 58
Query: 173 EELNLSWNSKVGGNLPLILQKFQKGSKIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLD 232
E L++S N NL + + S + + + S + + + L L VLD
Sbjct: 59 EHLSVSHN-----NLTTLHGEL---SSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLD 110
Query: 233 LSINRDIVGSLNSIAQGLKSTSNLKVLKLHSCGLSQKSV-KILDAAFRYLGELRKLDLSC 291
LS N+ L + L++ N+ VL LS S+ I + F L +L LDLS
Sbjct: 111 LSHNQ-----LTECPRELENAKNMLVL-----NLSHNSIDTIPNQLFINLTDLLYLDLSE 160
Query: 292 NKDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLSANKKM 351
N+ E P Q+ L HLQ L L+ L + L P ++ LQ L L + ++
Sbjct: 161 NR-----LESLPPQMRRLVHLQTLVLNGNPLLHAQLRQL----PAMTALQTLHLRSTQR- 210
Query: 352 GSSSENLLSRLRFLPALKSLVINNCALESETFTALAEASVHLSALEVFNLSWNKCVGGNL 411
+ NL + L L L + L T + E L +L NLS N+ L
Sbjct: 211 --TQSNLPTSLEGLSNLADV-----DLSCNDLTRVPECLYTLPSLRRLNLSSNQIT--EL 261
Query: 412 KLLLETLKLSMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLSYN 462
L ++ Q + + + +L + L S I L+KL+KL L+ N
Sbjct: 262 SLCID--------QWVHVETLNLSRNQLTSLPSAI--CKLSKLKKLYLNSN 302
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 53.9 bits (128), Expect = 4e-07
Identities = 67/235 (28%), Positives = 104/235 (44%), Gaps = 6/235 (2%)
Query: 200 IQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLKSTSN-LKV 258
++ + LV CS T++ L L + QSL ++LS N + + L+ L+
Sbjct: 785 LRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQR 844
Query: 259 LKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCNK--DLGGGFEDSPAQLVMLKHLQVLD 316
L L +C L++ + K L A EL L L+ N + G F + K LQ L
Sbjct: 845 LSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECK-LQTLV 903
Query: 317 LHQCSLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLRF-LPALKSLVINN 375
L C +T+D LT+++ S+L LDL N + L LR L L+ L +
Sbjct: 904 LWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWG 963
Query: 376 CALESETFTALAEASVHLSALEVFNLSWNKCVGGNLKLLLETLKLSM-SLQVLRL 429
C++ + L A +L +L N +K+L ETL S +L+ LRL
Sbjct: 964 CSIPPFSCEDLCSALSCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRL 1018
Score = 50.8 bits (120), Expect = 3e-06
Identities = 56/205 (27%), Positives = 87/205 (42%), Gaps = 3/205 (1%)
Query: 91 LDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVG-GTLLSITQQMHLVSKLKILRL 149
L L +C TT ++ L L +++S N + G L T H L+ L L
Sbjct: 788 LGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSL 847
Query: 150 GSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGS-KIQMIELVDC 208
+C LT + + L + EL L L+ N + + + + K+Q + L +C
Sbjct: 848 ENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNC 907
Query: 209 SLTSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGL-KSTSNLKVLKLHSCGLS 267
+TS+ L +LL SL LDL +N V + + + L K NL+ L L C +
Sbjct: 908 DITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIP 967
Query: 268 QKSVKILDAAFRYLGELRKLDLSCN 292
S + L +A L LDL N
Sbjct: 968 PFSCEDLCSALSCNQSLVTLDLGQN 992
Score = 40.4 bits (93), Expect = 0.004
Identities = 58/224 (25%), Positives = 89/224 (39%), Gaps = 4/224 (1%)
Query: 139 HLVSKLKILRLGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGS 198
H L+ L L SC TT L A E+ L +NLS N + L+ +
Sbjct: 780 HPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPK 839
Query: 199 -KIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLK-STSNL 256
+Q + L +C LT + L +L + + L L L+ N + + +GL+ L
Sbjct: 840 CFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKL 899
Query: 257 KVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFED-SPAQLVMLKHLQVL 315
+ L L +C ++ L + L LDL N G + A L +L+ L
Sbjct: 900 QTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCL 959
Query: 316 DLHQCSLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLL 359
L CS+ L + +L LDL N +GSS +L
Sbjct: 960 WLWGCSIPPFSCEDLCSALSCNQSLVTLDLGQN-PLGSSGVKML 1002
>gi|187937176 NACHT, leucine rich repeat and PYD containing 7 isoform
3 [Homo sapiens]
Length = 1037
Score = 53.9 bits (128), Expect = 4e-07
Identities = 62/225 (27%), Positives = 95/225 (42%), Gaps = 16/225 (7%)
Query: 71 SMEKNEHFLQKLGKKAVNKCLDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVGGT 130
+M + +HFLQ L L NC LT A K++ A+L L L ++ N +G T
Sbjct: 812 TMTRPKHFLQMLS---------LENCRLTEASCKDLAAVLVVSKKLTHLCLAKNP-IGDT 861
Query: 131 LLSITQQ--MHLVSKLKILRLGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLP 188
+ + + KL+ L L C +T + L EA + L L+LS N G
Sbjct: 862 GVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIARGLWI 921
Query: 189 LILQKFQKGSKIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQ 248
L ++ + L CSL LG L Q LE LDL N + +
Sbjct: 922 LCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFG 981
Query: 249 GLKS-TSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCN 292
L+ T +LK+L+L + + + K+L+ + KL + CN
Sbjct: 982 VLRQRTGSLKILRLKTYETNLEIKKLLEEVKE---KNPKLTIDCN 1023
Score = 47.8 bits (112), Expect = 3e-05
Identities = 55/182 (30%), Positives = 83/182 (45%), Gaps = 6/182 (3%)
Query: 284 LRKLDLSCNKDLGGGFEDSPAQLVMLKH-LQVLDLHQCSLTADDVMSLTQVIPLLSNLQE 342
L+ L LS N L G + KH LQ+L L C LT L V+ + L
Sbjct: 791 LKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTH 850
Query: 343 LDLSANKKMGSSSENLLSRLRFLPA-LKSLVINNCALESETFTALAEASVHLSALEVFNL 401
L L+ N + + L L + L++LV+ C++ L+EA +L +L
Sbjct: 851 LCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDL 910
Query: 402 SWNKCVGGNLKLLLETLKL-SMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLS 460
S N+ G L +L + L+ + +L+ LRL SCSL+ L S + + KL+ LDL
Sbjct: 911 SINQIARG-LWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQ--KLETLDLG 967
Query: 461 YN 462
N
Sbjct: 968 QN 969
Score = 42.7 bits (99), Expect = 9e-04
Identities = 56/222 (25%), Positives = 86/222 (38%), Gaps = 2/222 (0%)
Query: 144 LKILRLGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGSK-IQM 202
L+ LRLG T + + L+ L LS N + L+ + + +QM
Sbjct: 763 LQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQM 822
Query: 203 IELVDCSLTSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLKSTS-NLKVLKL 261
+ L +C LT L +L + + L L L+ N + + +GL L+ L L
Sbjct: 823 LSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVL 882
Query: 262 HSCGLSQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLVMLKHLQVLDLHQCS 321
C +++ + L A + L LDLS N+ G + A +L+ L L CS
Sbjct: 883 QQCSITKLGCRYLSEALQEACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLWSCS 942
Query: 322 LTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLR 363
L L + L+ LDL N S L LR
Sbjct: 943 LMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLR 984
>gi|46049100 NACHT, leucine rich repeat and PYD containing 7 isoform
1 [Homo sapiens]
Length = 1009
Score = 53.9 bits (128), Expect = 4e-07
Identities = 62/225 (27%), Positives = 95/225 (42%), Gaps = 16/225 (7%)
Query: 71 SMEKNEHFLQKLGKKAVNKCLDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVGGT 130
+M + +HFLQ L L NC LT A K++ A+L L L ++ N +G T
Sbjct: 784 TMTRPKHFLQMLS---------LENCRLTEASCKDLAAVLVVSKKLTHLCLAKNP-IGDT 833
Query: 131 LLSITQQ--MHLVSKLKILRLGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLP 188
+ + + KL+ L L C +T + L EA + L L+LS N G
Sbjct: 834 GVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIARGLWI 893
Query: 189 LILQKFQKGSKIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQ 248
L ++ + L CSL LG L Q LE LDL N + +
Sbjct: 894 LCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFG 953
Query: 249 GLKS-TSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCN 292
L+ T +LK+L+L + + + K+L+ + KL + CN
Sbjct: 954 VLRQRTGSLKILRLKTYETNLEIKKLLEEVKE---KNPKLTIDCN 995
Score = 47.8 bits (112), Expect = 3e-05
Identities = 55/182 (30%), Positives = 83/182 (45%), Gaps = 6/182 (3%)
Query: 284 LRKLDLSCNKDLGGGFEDSPAQLVMLKH-LQVLDLHQCSLTADDVMSLTQVIPLLSNLQE 342
L+ L LS N L G + KH LQ+L L C LT L V+ + L
Sbjct: 763 LKHLRLSANVLLDEGAMLLYKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTH 822
Query: 343 LDLSANKKMGSSSENLLSRLRFLPA-LKSLVINNCALESETFTALAEASVHLSALEVFNL 401
L L+ N + + L L + L++LV+ C++ L+EA +L +L
Sbjct: 823 LCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDL 882
Query: 402 SWNKCVGGNLKLLLETLKL-SMSLQVLRLSSCSLVTEDVALLASVIQTGHLAKLQKLDLS 460
S N+ G L +L + L+ + +L+ LRL SCSL+ L S + + KL+ LDL
Sbjct: 883 SINQIARG-LWILCQALENPNCNLKHLRLWSCSLMPFYCQHLGSALLSNQ--KLETLDLG 939
Query: 461 YN 462
N
Sbjct: 940 QN 941
Score = 42.7 bits (99), Expect = 9e-04
Identities = 56/222 (25%), Positives = 86/222 (38%), Gaps = 2/222 (0%)
Query: 144 LKILRLGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGSK-IQM 202
L+ LRLG T + + L+ L LS N + L+ + + +QM
Sbjct: 735 LQYLRLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLLYKTMTRPKHFLQM 794
Query: 203 IELVDCSLTSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLKSTS-NLKVLKL 261
+ L +C LT L +L + + L L L+ N + + +GL L+ L L
Sbjct: 795 LSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEGLSYPDCKLQTLVL 854
Query: 262 HSCGLSQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLVMLKHLQVLDLHQCS 321
C +++ + L A + L LDLS N+ G + A +L+ L L CS
Sbjct: 855 QQCSITKLGCRYLSEALQEACSLTNLDLSINQIARGLWILCQALENPNCNLKHLRLWSCS 914
Query: 322 LTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLR 363
L L + L+ LDL N S L LR
Sbjct: 915 LMPFYCQHLGSALLSNQKLETLDLGQNHLWKSGIIKLFGVLR 956
>gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]
Length = 1033
Score = 52.0 bits (123), Expect = 1e-06
Identities = 87/349 (24%), Positives = 142/349 (40%), Gaps = 9/349 (2%)
Query: 104 KEMVALLPFLPDLEELDISWNGFVGGTLLSITQQM-HLVSKLKILRLGSCRLTTDDVQAL 162
+E+ +L + L EL I N G + +++ + H KL+ L+L S T + L
Sbjct: 623 REICSLFYTMESLRELHIFDNDLNGISERILSKALEHSSCKLRTLKL-SYVSTASGFEDL 681
Query: 163 GEAFEMIPELEELNLSWNSKVGGNLPLILQKF--QKGSKIQMIELVDCSLTSEDGTFLGQ 220
+A L L+++ S + N+ +L + +I + L+ C L + + +
Sbjct: 682 LKALARNRSLTYLSINCTS-ISLNMFSLLHDILHEPTCQISHLSLMKCDLRASECEEIAS 740
Query: 221 LLPMLQSLEVLDLSINRDIVGSLNSIAQGLKSTS-NLKVLKLHSCGLSQKSVKILDAAFR 279
LL SL L LS N +N + L + L L L C L++ L
Sbjct: 741 LLISGGSLRKLTLSSNPLRSDGMNILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLL 800
Query: 280 YLGELRKLDLSCNKDLGGGFEDSPAQLVMLK-HLQVLDLHQCSLTADDVMSLTQVIPLLS 338
+ LR+LDL N+ G L+ L+ L L C ++D + VI
Sbjct: 801 FSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNE 860
Query: 339 NLQELDLSANKKMGSSSENLLSRLRFLPA-LKSLVINNCALESETFTALAEASVHLSALE 397
L+ L++ +NK + + L LR L ++ + C L S +LA LE
Sbjct: 861 KLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLE 920
Query: 398 VFNLSWNKCVGGNLKLLLETL-KLSMSLQVLRLSSCSLVTEDVALLASV 445
NL N + LLE+L L+V+ L L T+ LL +V
Sbjct: 921 RLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLPLTGLNTQTQQLLMTV 969
Score = 48.9 bits (115), Expect = 1e-05
Identities = 69/302 (22%), Positives = 118/302 (39%), Gaps = 23/302 (7%)
Query: 79 LQKLGKKAVNKCLDLNNCGL---------TTADMKEMVALLPFLPDLEELDISWNGFVGG 129
L + ++ ++K L+ ++C L T + ++++ L L L I+
Sbjct: 645 LNGISERILSKALEHSSCKLRTLKLSYVSTASGFEDLLKALARNRSLTYLSINCTSISLN 704
Query: 130 TLLSITQQMHLVS-KLKILRLGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLP 188
+ +H + ++ L L C L + + + L +L LS N +
Sbjct: 705 MFSLLHDILHEPTCQISHLSLMKCDLRASECEEIASLLISGGSLRKLTLSSNPLRSDGMN 764
Query: 189 LILQKF-QKGSKIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLDLSINR-DIVGSLNSI 246
++ + + LV C LT + LG++L +L LDL +NR G L+
Sbjct: 765 ILCDALLHPNCTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVT 824
Query: 247 AQGLKSTSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQL 306
L T L+ L L C S + + +LR L++ NK ED+ QL
Sbjct: 825 FPLLFPTCQLEELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNK-----IEDAGMQL 879
Query: 307 VM--LKH----LQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLS 360
+ L+H L + L +C LT+ SL V+ L+ L+L N LL
Sbjct: 880 LCGGLRHPNCMLVNIGLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLE 939
Query: 361 RL 362
L
Sbjct: 940 SL 941
>gi|118918429 NOD3 protein [Homo sapiens]
Length = 1065
Score = 51.6 bits (122), Expect = 2e-06
Identities = 67/320 (20%), Positives = 124/320 (38%), Gaps = 4/320 (1%)
Query: 129 GTLLSITQQMHLVSKLKILRLGSCRLTTDDVQALGEAFEMIP-ELEELNLSWNSKVGGNL 187
G L S+ Q+ KL RL + + ++ LG +++++L+ N
Sbjct: 627 GVLQSLLPQLLYCRKL---RLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGA 683
Query: 188 PLILQKFQKGSKIQMIELVDCSLTSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIA 247
+ + + ++L S+ + L L + ++L L L N S+A
Sbjct: 684 KALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMA 743
Query: 248 QGLKSTSNLKVLKLHSCGLSQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLV 307
+ L S L +L L + + + A + L++L S N GG + L
Sbjct: 744 EALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALK 803
Query: 308 MLKHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLRFLPA 367
+ + L+ LDL S++ V +L + L L L N ++ + L
Sbjct: 804 VNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANST 863
Query: 368 LKSLVINNCALESETFTALAEASVHLSALEVFNLSWNKCVGGNLKLLLETLKLSMSLQVL 427
LK+L + L + A+A A L +L WN G + L + L+L+ SL L
Sbjct: 864 LKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSL 923
Query: 428 RLSSCSLVTEDVALLASVIQ 447
L ++ + +A ++
Sbjct: 924 DLQENAIGDDGACAVARALK 943
Score = 51.2 bits (121), Expect = 2e-06
Identities = 72/355 (20%), Positives = 135/355 (38%), Gaps = 10/355 (2%)
Query: 143 KLKILRLGSCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGSKIQM 202
+++ + L +++ +AL + + L L+L NS + + +
Sbjct: 667 RIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTS 726
Query: 203 IELVDCSLTSEDGTFLGQLLPMLQSLEVLDLSINRDIVGSLNSIAQGLKSTSNLKVLKLH 262
+ L ++ + + + L ++L +L L N +A LK +LK L
Sbjct: 727 LSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFS 786
Query: 263 SCGLSQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLVMLKHLQVLDLHQCSL 322
S + K L A + L LDL N G L + L L L + S+
Sbjct: 787 SNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSI 846
Query: 323 TADDVMSLTQVIPLLSNLQELDLSANKKMGSSSENLLSRLRFLPALKSLVINNCALESET 382
+ + ++ + S L+ LDL+AN + + +R L SL + +++
Sbjct: 847 SPEGAQAIAHALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGA 906
Query: 383 FTALAEASVHLSALEVFNLSWNKCVGGNLKLLLETLKLSMSLQVLRLSSCSLVTEDVALL 442
AL +A +L +L N + LK++ +L L L S+ +L
Sbjct: 907 AQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQVL 966
Query: 443 ASVIQTGHLAKLQKLDLSYNDSICDAGWTMFCQNVRFLKELIELDISLRPSNFRD 497
+ L+ LDL N +I AG + L ++++ SLR N ++
Sbjct: 967 GEALAVNR--TLEILDLRGN-AIGVAG-------AKALANALKVNSSLRRLNLQE 1011
Score = 43.5 bits (101), Expect = 5e-04
Identities = 36/148 (24%), Positives = 65/148 (43%), Gaps = 5/148 (3%)
Query: 160 QALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGSKIQMIELVDCSLTSEDGTFLG 219
QALG+A ++ L L+L N+ + + + + + + L S+ + LG
Sbjct: 908 QALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQVLG 967
Query: 220 QLLPMLQSLEVLDLSINRDIVGSLNSIAQGLKSTSNLKVLKLHSCGLSQKSVKILDAAFR 279
+ L + ++LE+LDL N V ++A LK S+L+ L L L + A
Sbjct: 968 EALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLRRLNLQENSLGMDGAICIATALS 1027
Query: 280 YLGELRKLDLSCNKDLGGGFEDSPAQLV 307
L+ ++L G DS A+++
Sbjct: 1028 GNHRLQHINLQ-----GNHIGDSGARMI 1050
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 50.8 bits (120), Expect = 3e-06
Identities = 94/404 (23%), Positives = 160/404 (39%), Gaps = 64/404 (15%)
Query: 91 LDLNNCGLTTADMKEMVALLPFLPDLEELDISWNGFVGGTLLSITQQMHLVSKLKILRLG 150
LD NN ++ + L L LE LD+S+N +L+ + +H + +L++ +
Sbjct: 78 LDKNN-------LRSLCPALGLLSSLESLDLSYNPIFSSSLV-VVSFLHALRELRLYQ-- 127
Query: 151 SCRLTTDDVQALGEAFEMIPELEELNLSWNSKVGGNLPLILQKFQKGSKIQMIELVDCSL 210
TD + F+ + LE L L+ G +L + ++ +K++ I L
Sbjct: 128 -----TDLKEIPVVIFKNLHHLELLGLT-----GNHLKCLPKEIVNQTKLREI-----YL 172
Query: 211 TSEDGTFLGQLLPMLQSLEVLDLSINR-----DIVGSLNSIAQGLKSTSNLKVLKLHSCG 265
Q L +L +LE++DL N+ + +G L + + +++NL VL C
Sbjct: 173 KRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVLPASLCQ 232
Query: 266 LSQKSVKILDAAFRYLGELRKLDLSCNKDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTAD 325
SQ SV LD + L + K K G + + V + LH L
Sbjct: 233 CSQLSV--LDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNT 290
Query: 326 DVMSLTQVIPLLSNLQELDLSAN---------------KKMGSSSENLLSRLRFLPALKS 370
+ L L NL+ LDLS N + +G + L +L
Sbjct: 291 GLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSK 350
Query: 371 LVINNCALESETFTALAEASVHLSALEVFNLSWNKCVGGNLKLLLETLKLSMSLQVLRLS 430
L I L F + E + L++LE + ++ G L + E ++ SL+ L +
Sbjct: 351 LKI--LGLTGNEFLSFPEEVLSLASLEKLYIGQDQ--GFKLTYVPEHIRKLQSLKELYIE 406
Query: 431 SCSLVTEDVALLASVIQTGHLAKLQKLDLSYN------DSICDA 468
+ L V+L G + L+ LD +N D+IC A
Sbjct: 407 NNHLEYLPVSL-------GSMPNLEVLDCRHNLLKQLPDAICQA 443
Score = 40.0 bits (92), Expect = 0.006
Identities = 54/192 (28%), Positives = 85/192 (44%), Gaps = 29/192 (15%)
Query: 283 ELRKLDLSCNKDLGGGFEDSPAQLVMLKHLQVLDLHQCSLTADDVMSLTQVIPLLSNLQE 342
EL ++ L N+ E+ P ++ LK+++VL L + +++ SL + LLS+L+
Sbjct: 49 ELEEVHLENNQ-----IEEIPQEIQRLKNIRVLYLDK-----NNLRSLCPALGLLSSLES 98
Query: 343 LDLSANKKMGSSSENLLSRLRFLPALKSLVINNCALESETFTALAEASVHLSALEVFNLS 402
LDLS N SS L + FL AL+ L + L+ +L LE+ L+
Sbjct: 99 LDLSYNPIFSSS----LVVVSFLHALRELRLYQTDLKEIPVVIFK----NLHHLELLGLT 150
Query: 403 WN--KCVGG---NLKLLLETLKLSMSLQVLRLSSCSLVTEDVALL------ASVIQTGHL 451
N KC+ N L E +V C L T ++ L A + GHL
Sbjct: 151 GNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHL 210
Query: 452 AKLQKLDLSYND 463
LQK ++ N+
Sbjct: 211 TGLQKFYMASNN 222
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.317 0.132 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 18,932,209
Number of Sequences: 37866
Number of extensions: 762055
Number of successful extensions: 2997
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 34
Number of HSP's successfully gapped in prelim test: 139
Number of HSP's that attempted gapping in prelim test: 2413
Number of HSP's gapped (non-prelim): 407
length of query: 552
length of database: 18,247,518
effective HSP length: 107
effective length of query: 445
effective length of database: 14,195,856
effective search space: 6317155920
effective search space used: 6317155920
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.