Guide to the Human Genome
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Search of human proteins with 112789550

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|112789550 poly (ADP-ribose) polymerase family, member 4
[Homo sapiens]
         (1724 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|112789550 poly (ADP-ribose) polymerase family, member 4 [Homo...  3455   0.0  
gi|194306644 BCSC-1 isoform 1 [Homo sapiens]                          161   4e-39
gi|38195080 BCSC-1 isoform 1 [Homo sapiens]                           161   4e-39
gi|156523968 poly (ADP-ribose) polymerase family, member 1 [Homo...   114   6e-25
gi|38195082 BCSC-1 isoform 2 [Homo sapiens]                           114   6e-25
gi|210147462 von Willebrand factor A domain containing 5B1 [Homo...   105   3e-22
gi|110825963 poly (ADP-ribose) polymerase family, member 2 isofo...   103   1e-21
gi|110825961 poly (ADP-ribose) polymerase family, member 2 isofo...   103   1e-21
gi|158634482 poly (ADP-ribose) polymerase family, member 3 isofo...    79   4e-14
gi|158634478 poly (ADP-ribose) polymerase family, member 3 isofo...    79   4e-14
gi|31542984 inter-alpha (globulin) inhibitor H4 [Homo sapiens]         70   2e-11
gi|133925809 inter-alpha (globulin) inhibitor H3 preproprotein [...    52   7e-06
gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    48   9e-05
gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens]             47   1e-04
gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribo...    47   2e-04
gi|222352129 von Willebrand factor A domain containing 5B2 [Homo...    47   2e-04
gi|156119625 inter-alpha (globulin) inhibitor H1 [Homo sapiens]        44   0.002
gi|228008410 BEN domain containing 4 isoform b [Homo sapiens]          42   0.005
gi|148762950 BEN domain containing 4 isoform a [Homo sapiens]          42   0.005
gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapi...    42   0.007
gi|118498362 kinectin 1 isoform b [Homo sapiens]                       41   0.009
gi|38348336 inter-alpha (globulin) inhibitor H5-like [Homo sapiens]    40   0.015
gi|55750053 atrophin-1 [Homo sapiens]                                  40   0.015
gi|55750041 atrophin-1 [Homo sapiens]                                  40   0.015
gi|150417989 cyclin K isoform 1 [Homo sapiens]                         40   0.020
gi|58530876 melanoma antigen family C, 1 [Homo sapiens]                40   0.026
gi|18959210 WIRE protein [Homo sapiens]                                39   0.057
gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]          38   0.097
gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]          38   0.097
gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]          38   0.097

>gi|112789550 poly (ADP-ribose) polymerase family, member 4 [Homo
            sapiens]
          Length = 1724

 Score = 3455 bits (8959), Expect = 0.0
 Identities = 1724/1724 (100%), Positives = 1724/1724 (100%)

Query: 1    MVMGIFANCIFCLKVKYLPQQQKKKLQTDIKENGGKFSFSLNPQCTHIILDNADVLSQYQ 60
            MVMGIFANCIFCLKVKYLPQQQKKKLQTDIKENGGKFSFSLNPQCTHIILDNADVLSQYQ
Sbjct: 1    MVMGIFANCIFCLKVKYLPQQQKKKLQTDIKENGGKFSFSLNPQCTHIILDNADVLSQYQ 60

Query: 61   LNSIQKNHVHIANPDFIWKSIREKRLLDVKNYDPYKPLDITPPPDQKASSSEVKTEGLCP 120
            LNSIQKNHVHIANPDFIWKSIREKRLLDVKNYDPYKPLDITPPPDQKASSSEVKTEGLCP
Sbjct: 61   LNSIQKNHVHIANPDFIWKSIREKRLLDVKNYDPYKPLDITPPPDQKASSSEVKTEGLCP 120

Query: 121  DSATEEEDTVELTEFGMQNVEIPHLPQDFEVAKYNTLEKVGMEGGQEAVVVELQCSRDSR 180
            DSATEEEDTVELTEFGMQNVEIPHLPQDFEVAKYNTLEKVGMEGGQEAVVVELQCSRDSR
Sbjct: 121  DSATEEEDTVELTEFGMQNVEIPHLPQDFEVAKYNTLEKVGMEGGQEAVVVELQCSRDSR 180

Query: 181  DCPFLISSHFLLDDGMETRRQFAIKKTSEDASEYFENYIEELKKQGFLLREHFTPEATQL 240
            DCPFLISSHFLLDDGMETRRQFAIKKTSEDASEYFENYIEELKKQGFLLREHFTPEATQL
Sbjct: 181  DCPFLISSHFLLDDGMETRRQFAIKKTSEDASEYFENYIEELKKQGFLLREHFTPEATQL 240

Query: 241  ASEQLQALLLEEVMNSSTLSQEVSDLVEMIWAEALGHLEHMLLKPVNRISLNDVSKAEGI 300
            ASEQLQALLLEEVMNSSTLSQEVSDLVEMIWAEALGHLEHMLLKPVNRISLNDVSKAEGI
Sbjct: 241  ASEQLQALLLEEVMNSSTLSQEVSDLVEMIWAEALGHLEHMLLKPVNRISLNDVSKAEGI 300

Query: 301  LLLVKAALKNGETAEQLQKMMTEFYRLIPHKGTMPKEVNLGLLAKKADLCQLIRDMVNVC 360
            LLLVKAALKNGETAEQLQKMMTEFYRLIPHKGTMPKEVNLGLLAKKADLCQLIRDMVNVC
Sbjct: 301  LLLVKAALKNGETAEQLQKMMTEFYRLIPHKGTMPKEVNLGLLAKKADLCQLIRDMVNVC 360

Query: 361  ETNLSKPNPPSLAKYRALRCKIEHVEQNTEEFLRVRKEVLQNHHSKSPVDVLQIFRVGRV 420
            ETNLSKPNPPSLAKYRALRCKIEHVEQNTEEFLRVRKEVLQNHHSKSPVDVLQIFRVGRV
Sbjct: 361  ETNLSKPNPPSLAKYRALRCKIEHVEQNTEEFLRVRKEVLQNHHSKSPVDVLQIFRVGRV 420

Query: 421  NETTEFLSKLGNVRPLLHGSPVQNIVGILCRGLLLPKVVEDRGVQRTDVGNLGSGIYFSD 480
            NETTEFLSKLGNVRPLLHGSPVQNIVGILCRGLLLPKVVEDRGVQRTDVGNLGSGIYFSD
Sbjct: 421  NETTEFLSKLGNVRPLLHGSPVQNIVGILCRGLLLPKVVEDRGVQRTDVGNLGSGIYFSD 480

Query: 481  SLSTSIKYSHPGETDGTRLLLICDVALGKCMDLHEKDFSLTEAPPGYDSVHGVSQTASVT 540
            SLSTSIKYSHPGETDGTRLLLICDVALGKCMDLHEKDFSLTEAPPGYDSVHGVSQTASVT
Sbjct: 481  SLSTSIKYSHPGETDGTRLLLICDVALGKCMDLHEKDFSLTEAPPGYDSVHGVSQTASVT 540

Query: 541  TDFEDDEFVVYKTNQVKMKYIIKFSMPGDQIKDFHPSDHTELEEYRPEFSNFSKVEDYQL 600
            TDFEDDEFVVYKTNQVKMKYIIKFSMPGDQIKDFHPSDHTELEEYRPEFSNFSKVEDYQL
Sbjct: 541  TDFEDDEFVVYKTNQVKMKYIIKFSMPGDQIKDFHPSDHTELEEYRPEFSNFSKVEDYQL 600

Query: 601  PDAKTSSSTKAGLQDASGNLVPLEDVHIKGRIIDTVAQVIVFQTYTNKSHVPIEAKYIFP 660
            PDAKTSSSTKAGLQDASGNLVPLEDVHIKGRIIDTVAQVIVFQTYTNKSHVPIEAKYIFP
Sbjct: 601  PDAKTSSSTKAGLQDASGNLVPLEDVHIKGRIIDTVAQVIVFQTYTNKSHVPIEAKYIFP 660

Query: 661  LDDKAAVCGFEAFINGKHIVGEIKEKEEAQQEYLEAVTQGHGAYLMSQDAPDVFTVSVGN 720
            LDDKAAVCGFEAFINGKHIVGEIKEKEEAQQEYLEAVTQGHGAYLMSQDAPDVFTVSVGN
Sbjct: 661  LDDKAAVCGFEAFINGKHIVGEIKEKEEAQQEYLEAVTQGHGAYLMSQDAPDVFTVSVGN 720

Query: 721  LPPKAKVLIKITYITELSILGTVGVFFMPATVAPWQQDKALNENLQDTVEKICIKEIGTK 780
            LPPKAKVLIKITYITELSILGTVGVFFMPATVAPWQQDKALNENLQDTVEKICIKEIGTK
Sbjct: 721  LPPKAKVLIKITYITELSILGTVGVFFMPATVAPWQQDKALNENLQDTVEKICIKEIGTK 780

Query: 781  QSFSLTMSIEMPYVIEFIFSDTHELKQKRTDCKAVISTMEGSSLDSSGFSLHIGLSAAYL 840
            QSFSLTMSIEMPYVIEFIFSDTHELKQKRTDCKAVISTMEGSSLDSSGFSLHIGLSAAYL
Sbjct: 781  QSFSLTMSIEMPYVIEFIFSDTHELKQKRTDCKAVISTMEGSSLDSSGFSLHIGLSAAYL 840

Query: 841  PRMWVEKHPEKESEACMLVFQPDLDVDLPDLASESEVIICLDCSSSMEGVTFLQAKQIAL 900
            PRMWVEKHPEKESEACMLVFQPDLDVDLPDLASESEVIICLDCSSSMEGVTFLQAKQIAL
Sbjct: 841  PRMWVEKHPEKESEACMLVFQPDLDVDLPDLASESEVIICLDCSSSMEGVTFLQAKQIAL 900

Query: 901  HALSLVGEKQKVNIIQFGTGYKELFSYPKHITSNTMAAEFIMSATPTMGNTDFWKTLRYL 960
            HALSLVGEKQKVNIIQFGTGYKELFSYPKHITSNTMAAEFIMSATPTMGNTDFWKTLRYL
Sbjct: 901  HALSLVGEKQKVNIIQFGTGYKELFSYPKHITSNTMAAEFIMSATPTMGNTDFWKTLRYL 960

Query: 961  SLLYPARGSRNILLVSDGHLQDESLTLQLVKRSRPHTRLFACGIGSTANRHVLRILSQCG 1020
            SLLYPARGSRNILLVSDGHLQDESLTLQLVKRSRPHTRLFACGIGSTANRHVLRILSQCG
Sbjct: 961  SLLYPARGSRNILLVSDGHLQDESLTLQLVKRSRPHTRLFACGIGSTANRHVLRILSQCG 1020

Query: 1021 AGVFEYFNAKSKHSWRKQIEDQMTRLCSPSCHSVSVKWQQLNPDVPEALQAPAQVPSLFL 1080
            AGVFEYFNAKSKHSWRKQIEDQMTRLCSPSCHSVSVKWQQLNPDVPEALQAPAQVPSLFL
Sbjct: 1021 AGVFEYFNAKSKHSWRKQIEDQMTRLCSPSCHSVSVKWQQLNPDVPEALQAPAQVPSLFL 1080

Query: 1081 NDRLLVYGFIPHCTQATLCALIQEKEFRTMVSTTELQKTTGTMIHKLAARALIRDYEDGI 1140
            NDRLLVYGFIPHCTQATLCALIQEKEFRTMVSTTELQKTTGTMIHKLAARALIRDYEDGI
Sbjct: 1081 NDRLLVYGFIPHCTQATLCALIQEKEFRTMVSTTELQKTTGTMIHKLAARALIRDYEDGI 1140

Query: 1141 LHENETSHEMKKQTLKSLIIKLSKENSLITQFTSFVAVEKRDENESPFPDIPKVSELIAK 1200
            LHENETSHEMKKQTLKSLIIKLSKENSLITQFTSFVAVEKRDENESPFPDIPKVSELIAK
Sbjct: 1141 LHENETSHEMKKQTLKSLIIKLSKENSLITQFTSFVAVEKRDENESPFPDIPKVSELIAK 1200

Query: 1201 EDVDFLPYMSWQGEPQEAVRNQSLLASSEWPELRLSKRKHRKIPFSKRKMELSQPEVSED 1260
            EDVDFLPYMSWQGEPQEAVRNQSLLASSEWPELRLSKRKHRKIPFSKRKMELSQPEVSED
Sbjct: 1201 EDVDFLPYMSWQGEPQEAVRNQSLLASSEWPELRLSKRKHRKIPFSKRKMELSQPEVSED 1260

Query: 1261 FEEDGLGVLPAFTSNLERGGVEKLLDLSWTESCKPTATEPLFKKVSPWETSTSSFFPILA 1320
            FEEDGLGVLPAFTSNLERGGVEKLLDLSWTESCKPTATEPLFKKVSPWETSTSSFFPILA
Sbjct: 1261 FEEDGLGVLPAFTSNLERGGVEKLLDLSWTESCKPTATEPLFKKVSPWETSTSSFFPILA 1320

Query: 1321 PAVGSYLPPTARAHSPASLSFASYRQVASFGSAAPPRQFDASQFSQGPVPGTCADWIPQS 1380
            PAVGSYLPPTARAHSPASLSFASYRQVASFGSAAPPRQFDASQFSQGPVPGTCADWIPQS
Sbjct: 1321 PAVGSYLPPTARAHSPASLSFASYRQVASFGSAAPPRQFDASQFSQGPVPGTCADWIPQS 1380

Query: 1381 ASCPTGPPQNPPSSPYCGIVFSGSSLSSAQSAPLQHPGGFTTRPSAGTFPELDSPQLHFS 1440
            ASCPTGPPQNPPSSPYCGIVFSGSSLSSAQSAPLQHPGGFTTRPSAGTFPELDSPQLHFS
Sbjct: 1381 ASCPTGPPQNPPSSPYCGIVFSGSSLSSAQSAPLQHPGGFTTRPSAGTFPELDSPQLHFS 1440

Query: 1441 LPTDPDPIRGFGSYHPSASSPFHFQPSAASLTANLRLPMASALPEALCSQSRTTPVDLCL 1500
            LPTDPDPIRGFGSYHPSASSPFHFQPSAASLTANLRLPMASALPEALCSQSRTTPVDLCL
Sbjct: 1441 LPTDPDPIRGFGSYHPSASSPFHFQPSAASLTANLRLPMASALPEALCSQSRTTPVDLCL 1500

Query: 1501 LEESVGSLEGSRCPVFAFQSSDTESDELSEVLQDSCFLQIKCDTKDDSILCFLEVKEEDE 1560
            LEESVGSLEGSRCPVFAFQSSDTESDELSEVLQDSCFLQIKCDTKDDSILCFLEVKEEDE
Sbjct: 1501 LEESVGSLEGSRCPVFAFQSSDTESDELSEVLQDSCFLQIKCDTKDDSILCFLEVKEEDE 1560

Query: 1561 IVCIQHWQDAVPWTELLSLQTEDGFWKLTPELGLILNLNTNGLHSFLKQKGIQSLGVKGR 1620
            IVCIQHWQDAVPWTELLSLQTEDGFWKLTPELGLILNLNTNGLHSFLKQKGIQSLGVKGR
Sbjct: 1561 IVCIQHWQDAVPWTELLSLQTEDGFWKLTPELGLILNLNTNGLHSFLKQKGIQSLGVKGR 1620

Query: 1621 ECLLDLIATMLVLQFIRTRLEKEGIVFKSLMKMDDASISRNIPWAFEAIKQASEWVRRTE 1680
            ECLLDLIATMLVLQFIRTRLEKEGIVFKSLMKMDDASISRNIPWAFEAIKQASEWVRRTE
Sbjct: 1621 ECLLDLIATMLVLQFIRTRLEKEGIVFKSLMKMDDASISRNIPWAFEAIKQASEWVRRTE 1680

Query: 1681 GQYPSICPRLELGNDWDSATKQLLGLQPISTVSPLHRVLHYSQG 1724
            GQYPSICPRLELGNDWDSATKQLLGLQPISTVSPLHRVLHYSQG
Sbjct: 1681 GQYPSICPRLELGNDWDSATKQLLGLQPISTVSPLHRVLHYSQG 1724


>gi|194306644 BCSC-1 isoform 1 [Homo sapiens]
          Length = 786

 Score =  161 bits (408), Expect = 4e-39
 Identities = 156/596 (26%), Positives = 270/596 (45%), Gaps = 53/596 (8%)

Query: 621  VPLEDVHIKGRIIDTVAQVIVFQTYTNKSHVPIEAKYIFPLDDKAAVCGFEAFINGKHIV 680
            VPL+ + +   I + VA V     Y N+  VP+EA ++FP+D+ +AV  FEA ++GK IV
Sbjct: 15   VPLKSISVSVNIYEFVAGVSATLNYENEEKVPLEAFFVFPMDEDSAVYSFEALVDGKKIV 74

Query: 681  GEIKEKEEAQQEYLEAVTQGHGAYLMSQDAP--DVFTVSVGNLPPKAKVLIKITYITELS 738
             E+++K +A+  Y +A++QGH A+L+  D+   DVF+ +VGNL P +K  + + Y+ EL 
Sbjct: 75   AELQDKMKARTNYEKAISQGHQAFLLEGDSSSRDVFSCNVGNLQPGSKAAVTLKYVQELP 134

Query: 739  ILGTVGV-FFMPATVAPWQQDKALNENLQDTVEKICIKEIGTKQSFSLTMSIEMPYVIEF 797
            +     + F +PA + P  Q    +++    V+   +       + S+  +I+  + IE 
Sbjct: 135  LEADGALRFVLPAVLNPRYQFSGSSKDSCLNVKTPIVPVEDLPYTLSMVATIDSQHGIEK 194

Query: 798  I-----FSDTHELKQKRTDCKAVISTMEGSSLDSSGFSLHIGLSAAYLPRMWVEK-HPEK 851
            +      S T  L + +T   A +S   G   D     L I  +  + P + +E   P  
Sbjct: 195  VQSNCPLSPTEYLGEDKT--SAQVSLAAGHKFDRD-VELLIYYNEVHTPSVVLEMGMPNM 251

Query: 852  E------SEACMLVFQPDLDVDLPDLASESEVIICLDCSSSMEGVTFLQ---------AK 896
            +        + M+ F P++  D P      E I  +D S SM+     Q         AK
Sbjct: 252  KPGHLMGDPSAMVSFYPNIPEDQPSNTC-GEFIFLMDRSGSMQSPMSSQDTSQLRIQAAK 310

Query: 897  QIALHALSLVGEKQKVNIIQFGTGYKELFSYPKHITSNTM--AAEFIMSATPTMGNTDFW 954
            +  +  L  +      NI  FG+ Y+  F      T  TM  A   +      +G T+  
Sbjct: 311  ETLILLLKSLPIGCYFNIYGFGSSYEACFPESVKYTQQTMEEALGRVKLMQADLGGTEIL 370

Query: 955  KTLR--YLSLLYPARGSRNILLVSDGHLQDESLTLQLVKRSRPHTRLFACGIGSTANRHV 1012
              L+  Y     P      + + +DG + D    ++ V+ +R   R F+ GIG   +  +
Sbjct: 371  APLQNIYRGPSIPGH-PLQLFVFTDGEVTDTFSVIKEVRINRQKHRCFSFGIGEGTSTSL 429

Query: 1013 LRILSQCGAGVFEYFNAKSKHSWRKQIEDQMTRLCSPSCHSVSVKWQQLNPDVPEALQAP 1072
            ++ +++   G  E+   K +   + +    + R   P    VS+ W  L P +   + +P
Sbjct: 430  IKGIARASGGTSEFITGKDR--MQSKALRTLKRSLQPVVEDVSLSW-HLPPGLSAKMLSP 486

Query: 1073 AQVPSLFLNDRLLVY----GFIPHC-TQATLCA--LIQEKEFRTMVS-TTELQKTTGTMI 1124
             Q   +F   RL+ Y    G +P   T   +C    +Q K F   V+   + +      I
Sbjct: 487  EQT-VIFRGQRLISYAQLTGRMPAAETTGEVCLKYTLQGKTFEDKVTFPLQPKPDVNLTI 545

Query: 1125 HKLAARALIRDYEDGILHENETSHEMKKQTLKSLIIKLSKENSLITQFTSFVAVEK 1180
            H+LAA++L++  + G+    ET    KK  L      LS E+ +I+ FT+F+A+ K
Sbjct: 546  HRLAAKSLLQTKDMGL---RETPASDKKDAL-----NLSLESGVISSFTAFIAINK 593


>gi|38195080 BCSC-1 isoform 1 [Homo sapiens]
          Length = 786

 Score =  161 bits (408), Expect = 4e-39
 Identities = 156/596 (26%), Positives = 270/596 (45%), Gaps = 53/596 (8%)

Query: 621  VPLEDVHIKGRIIDTVAQVIVFQTYTNKSHVPIEAKYIFPLDDKAAVCGFEAFINGKHIV 680
            VPL+ + +   I + VA V     Y N+  VP+EA ++FP+D+ +AV  FEA ++GK IV
Sbjct: 15   VPLKSISVSVNIYEFVAGVSATLNYENEEKVPLEAFFVFPMDEDSAVYSFEALVDGKKIV 74

Query: 681  GEIKEKEEAQQEYLEAVTQGHGAYLMSQDAP--DVFTVSVGNLPPKAKVLIKITYITELS 738
             E+++K +A+  Y +A++QGH A+L+  D+   DVF+ +VGNL P +K  + + Y+ EL 
Sbjct: 75   AELQDKMKARTNYEKAISQGHQAFLLEGDSSSRDVFSCNVGNLQPGSKAAVTLKYVQELP 134

Query: 739  ILGTVGV-FFMPATVAPWQQDKALNENLQDTVEKICIKEIGTKQSFSLTMSIEMPYVIEF 797
            +     + F +PA + P  Q    +++    V+   +       + S+  +I+  + IE 
Sbjct: 135  LEADGALRFVLPAVLNPRYQFSGSSKDSCLNVKTPIVPVEDLPYTLSMVATIDSQHGIEK 194

Query: 798  I-----FSDTHELKQKRTDCKAVISTMEGSSLDSSGFSLHIGLSAAYLPRMWVEK-HPEK 851
            +      S T  L + +T   A +S   G   D     L I  +  + P + +E   P  
Sbjct: 195  VQSNCPLSPTEYLGEDKT--SAQVSLAAGHKFDRD-VELLIYYNEVHTPSVVLEMGMPNM 251

Query: 852  E------SEACMLVFQPDLDVDLPDLASESEVIICLDCSSSMEGVTFLQ---------AK 896
            +        + M+ F P++  D P      E I  +D S SM+     Q         AK
Sbjct: 252  KPGHLMGDPSAMVSFYPNIPEDQPSNTC-GEFIFLMDRSGSMQSPMSSQDTSQLRIQAAK 310

Query: 897  QIALHALSLVGEKQKVNIIQFGTGYKELFSYPKHITSNTM--AAEFIMSATPTMGNTDFW 954
            +  +  L  +      NI  FG+ Y+  F      T  TM  A   +      +G T+  
Sbjct: 311  ETLILLLKSLPIGCYFNIYGFGSSYEACFPESVKYTQQTMEEALGRVKLMQADLGGTEIL 370

Query: 955  KTLR--YLSLLYPARGSRNILLVSDGHLQDESLTLQLVKRSRPHTRLFACGIGSTANRHV 1012
              L+  Y     P      + + +DG + D    ++ V+ +R   R F+ GIG   +  +
Sbjct: 371  APLQNIYRGPSIPGH-PLQLFVFTDGEVTDTFSVIKEVRINRQKHRCFSFGIGEGTSTSL 429

Query: 1013 LRILSQCGAGVFEYFNAKSKHSWRKQIEDQMTRLCSPSCHSVSVKWQQLNPDVPEALQAP 1072
            ++ +++   G  E+   K +   + +    + R   P    VS+ W  L P +   + +P
Sbjct: 430  IKGIARASGGTSEFITGKDR--MQSKALRTLKRSLQPVVEDVSLSW-HLPPGLSAKMLSP 486

Query: 1073 AQVPSLFLNDRLLVY----GFIPHC-TQATLCA--LIQEKEFRTMVS-TTELQKTTGTMI 1124
             Q   +F   RL+ Y    G +P   T   +C    +Q K F   V+   + +      I
Sbjct: 487  EQT-VIFRGQRLISYAQLTGRMPAAETTGEVCLKYTLQGKTFEDKVTFPLQPKPDVNLTI 545

Query: 1125 HKLAARALIRDYEDGILHENETSHEMKKQTLKSLIIKLSKENSLITQFTSFVAVEK 1180
            H+LAA++L++  + G+    ET    KK  L      LS E+ +I+ FT+F+A+ K
Sbjct: 546  HRLAAKSLLQTKDMGL---RETPASDKKDAL-----NLSLESGVISSFTAFIAINK 593


>gi|156523968 poly (ADP-ribose) polymerase family, member 1 [Homo
            sapiens]
          Length = 1014

 Score =  114 bits (286), Expect = 6e-25
 Identities = 150/624 (24%), Positives = 258/624 (41%), Gaps = 103/624 (16%)

Query: 21   QQKKKLQTDIKENGGKFSFSLNPQCTHIILDNADVLSQYQLNSIQKNHVHIANPDFIW-- 78
            + K +++  I++ GGK + + N     I           ++  +++ ++ + + DF+   
Sbjct: 403  RNKDEVKAMIEKLGGKLTGTANKASLCISTKKEVEKMNKKMEEVKEANIRVVSEDFLQDV 462

Query: 79   ----KSIREKRLLDVKNYDPY------KPLDITPPPDQ------KASSSEVKTEGLCPDS 122
                KS++E  L  + +  P+      +P+++  P  +      K S  +VK EG+    
Sbjct: 463  SASTKSLQELFLAHILS--PWGAEVKAEPVEVVAPRGKSGAALSKKSKGQVKEEGI---- 516

Query: 123  ATEEEDTVELTEFGMQNVEIPHLPQDFEVAKYNTLEKVGMEGGQEAVVVE---------- 172
              + E  ++LT  G   V+    P        + LEK G        +V+          
Sbjct: 517  -NKSEKRMKLTLKGGAAVD----PDSGLEHSAHVLEKGGKVFSATLGLVDIVKGTNSYYK 571

Query: 173  LQCSRDSRDCPFLISSHFLLDDGMETRRQFAIKKTSEDASEYFENYIEELKKQGFLLR-- 230
            LQ   D ++  + I   +     +    +     + EDA E+F    EE     +  +  
Sbjct: 572  LQLLEDDKENRYWIFRSWGRVGTVIGSNKLEQMPSKEDAIEHFMKLYEEKTGNAWHSKNF 631

Query: 231  ----EHFTP-EATQLASEQLQALLLEEVMNSSTLSQEVSDLVEMIW-----AEALGHLEH 280
                + F P E      E+    L       S L + V DL++MI+      +A+   E 
Sbjct: 632  TKYPKKFYPLEIDYGQDEEAVKKLTVNPGTKSKLPKPVQDLIKMIFDVESMKKAMVEYEI 691

Query: 281  MLLK-PVNRISLNDVSKAEGILLLVKAALKNGETAEQLQKMMTEFYRLIPHKGTMPKEVN 339
             L K P+ ++S   +  A  IL  V+ A+  G +  Q+  +   FY LIPH   M K   
Sbjct: 692  DLQKMPLGKLSKRQIQAAYSILSEVQQAVSQGSSDSQILDLSNRFYTLIPHDFGMKKPP- 750

Query: 340  LGLLAKKADLCQLIRDMV-NVCETNLS----------KPNPPSLAKYRALRCKIEHVEQN 388
               L   AD  Q   +M+ N+ +  ++              P    Y  L+  I+ V+++
Sbjct: 751  ---LLNNADSVQAKVEMLDNLLDIEVAYSLLRGGSDDSSKDPIDVNYEKLKTDIKVVDRD 807

Query: 389  TEEFLRVRKEVLQNH---HSKSPVDVLQIFRVGRVNETTEF--LSKLGNVRPLLHGSPVQ 443
            +EE   +RK V   H   H+   ++V+ IF++ R  E   +    +L N R L HGS   
Sbjct: 808  SEEAEIIRKYVKNTHATTHNAYDLEVIDIFKIEREGECQRYKPFKQLHNRRLLWHGSRTT 867

Query: 444  NIVGILCRGL-LLPKVVEDRGVQRTDVGNLGSGIYFSDSLSTSIKYSHPGETDGTRLLLI 502
            N  GIL +GL + P      G         G GIYF+D +S S  Y H  + D   L+L+
Sbjct: 868  NFAGILSQGLRIAPPEAPVTGYM------FGKGIYFADMVSKSANYCHTSQGDPIGLILL 921

Query: 503  CDVALGKCMDLHEKDFSLTEAPPGYDSVHGVSQT-----ASVTTDFED------------ 545
             +VALG   +L      +++ P G  SV G+ +T     A+++ D  D            
Sbjct: 922  GEVALGNMYELKHAS-HISKLPKGKHSVKGLGKTTPDPSANISLDGVDVPLGTGISSGVN 980

Query: 546  ------DEFVVYKTNQVKMKYIIK 563
                  +E++VY   QV +KY++K
Sbjct: 981  DTSLLYNEYIVYDIAQVNLKYLLK 1004


>gi|38195082 BCSC-1 isoform 2 [Homo sapiens]
          Length = 415

 Score =  114 bits (286), Expect = 6e-25
 Identities = 107/406 (26%), Positives = 183/406 (45%), Gaps = 33/406 (8%)

Query: 621 VPLEDVHIKGRIIDTVAQVIVFQTYTNKSHVPIEAKYIFPLDDKAAVCGFEAFINGKHIV 680
           VPL+ + +   I + VA V     Y N+  VP+EA ++FP+D+ +AV  FEA ++GK IV
Sbjct: 15  VPLKSISVSVNIYEFVAGVSATLNYENEEKVPLEAFFVFPMDEDSAVYSFEALVDGKKIV 74

Query: 681 GEIKEKEEAQQEYLEAVTQGHGAYLMSQDAP--DVFTVSVGNLPPKAKVLIKITYITELS 738
            E+++K +A+  Y +A++QGH A+L+  D+   DVF+ +VGNL P +K  + + Y+ EL 
Sbjct: 75  AELQDKMKARTNYEKAISQGHQAFLLEGDSSSRDVFSCNVGNLQPGSKAAVTLKYVQELP 134

Query: 739 ILGTVGV-FFMPATVAPWQQDKALNENLQDTVEKICIKEIGTKQSFSLTMSIEMPYVIEF 797
           +     + F +PA + P  Q    +++    V+   +       + S+  +I+  + IE 
Sbjct: 135 LEADGALRFVLPAVLNPRYQFSGSSKDSCLNVKTPIVPVEDLPYTLSMVATIDSQHGIEK 194

Query: 798 I-----FSDTHELKQKRTDCKAVISTMEGSSLDSSGFSLHIGLSAAYLPRMWVEK-HPEK 851
           +      S T  L + +T   A +S   G   D     L I  +  + P + +E   P  
Sbjct: 195 VQSNCPLSPTEYLGEDKT--SAQVSLAAGHKFDRD-VELLIYYNEVHTPSVVLEMGMPNM 251

Query: 852 E------SEACMLVFQPDLDVDLPDLASESEVIICLDCSSSMEGVTFLQ---------AK 896
           +        + M+ F P++  D P      E I  +D S SM+     Q         AK
Sbjct: 252 KPGHLMGDPSAMVSFYPNIPEDQPSNTC-GEFIFLMDRSGSMQSPMSSQDTSQLRIQAAK 310

Query: 897 QIALHALSLVGEKQKVNIIQFGTGYKELFSYPKHITSNTM--AAEFIMSATPTMGNTDFW 954
           +  +  L  +      NI  FG+ Y+  F      T  TM  A   +      +G T+  
Sbjct: 311 ETLILLLKSLPIGCYFNIYGFGSSYEACFPESVKYTQQTMEEALGRVKLMQADLGGTEIL 370

Query: 955 KTLR--YLSLLYPARGSRNILLVSDGHLQDESLTLQLVKRSRPHTR 998
             L+  Y     P      + + +DG + D    ++ V+ +R   R
Sbjct: 371 APLQNIYRGPSIPGH-PLQLFVFTDGEVTDTFSVIKEVRINRQKHR 415


>gi|210147462 von Willebrand factor A domain containing 5B1 [Homo
            sapiens]
          Length = 1215

 Score =  105 bits (263), Expect = 3e-22
 Identities = 121/543 (22%), Positives = 216/543 (39%), Gaps = 100/543 (18%)

Query: 644  TYTNKSHVPIEAKYIFPLDDKAAVCGFEAFINGKHIVGEIKEKEEAQQEYLEA------V 697
            TY N    P +  +++PLD+   V GFEA I  + +  +IK+K + +  + +A       
Sbjct: 36   TYGNLEAQPFQGLFVYPLDECTTVIGFEAVIADRVVTVQIKDKAKLESGHFDASHVRSPT 95

Query: 698  TQGH---------------GAYLMSQDAPDV-FTVSVGNLPPKAKVLIKITYITELSILG 741
              G+               G   + +D   + F  ++G + P   V I I+  +EL  L 
Sbjct: 96   VTGNILQDGVSIAPHSCTPGKVTLDEDLERILFVANLGTIAPMENVTIFISTSSELPTLP 155

Query: 742  TVGV-FFMPATVAPW------QQDKALNENLQD------------TVEKICIKEIGTKQ- 781
            +  V   +PA  AP       +     N+  Q             +  K+C+  +   + 
Sbjct: 156  SGAVRVLLPAVCAPTVPQFCTKSTGTSNQQAQGKDRHCFGAWAPGSWNKLCLATLLNTEV 215

Query: 782  ------SFSLTMSIEMPYVIEFIFSDTHELKQKRT----DCKAVISTMEGSSLDSSGFSL 831
                   F+  + I  P ++  + S THE++          K++I T+           +
Sbjct: 216  SNPMEYEFNFQLEIRGPCLLAGVESPTHEIRADAAPSARSAKSIIITLANKHTFDRPVEI 275

Query: 832  HIGLSAAYLPRMWVEK--------------------------HPEKESE----------- 854
             I  S  ++P + +EK                            E+++E           
Sbjct: 276  LIHPSEPHMPHVLIEKGDMTLGEFDQHLKGRTDFIKGMKKKSRAERKTEIIRKRLHKDIP 335

Query: 855  ---ACMLVFQPDLDVDLPDLA-SESEVIICLDCSSSMEGVTFLQAKQIALHALSLVGEKQ 910
                 ML F PDL    P L  +  E I  +D SSSM G++  + K   L AL  +    
Sbjct: 336  HHSVIMLNFCPDLQSVQPCLRKAHGEFIFLIDRSSSMSGISMHRVKDAMLVALKSLMPAC 395

Query: 911  KVNIIQFGTGYKELFSYPKHITSNT--MAAEFIMSATPTMGNTDFWKTLRYLSLLYPARG 968
              NII FG+ +K LF   +  + ++  MA + I      MG T+    L+++      RG
Sbjct: 396  LFNIIGFGSTFKSLFPSSQTYSEDSLAMACDDIQRMKADMGGTNILSPLKWVIRQPVHRG 455

Query: 969  -SRNILLVSDGHLQDESLTLQLVKRSRPHTRLFACGIGSTANRHVLRILSQCGAGVFEYF 1027
              R + +++DG + +    L+LV+     TR ++ GIG      +++ L+    G  E  
Sbjct: 456  HPRLLFVITDGAVNNTGKVLELVRNHAFSTRCYSFGIGPNVCHRLVKGLASVSEGSAELL 515

Query: 1028 NAKSKHSWRKQIEDQMTRLCSPSCHSVSVKWQQLNPDVPEALQAPAQVPSLFLNDRLLVY 1087
                +   + ++   + +  +P    V+V+W  + P+  E L +P    SLF  +RL+ Y
Sbjct: 516  MEGER--LQPKMVKSLKKAMAPVLSDVTVEW--IFPETTEVLVSPVSASSLFPGERLVGY 571

Query: 1088 GFI 1090
            G +
Sbjct: 572  GIV 574



 Score = 35.0 bits (79), Expect = 0.63
 Identities = 28/111 (25%), Positives = 48/111 (43%), Gaps = 9/111 (8%)

Query: 1125 HKLAARALIRDYEDGILHENETSHEMKKQTLKSLIIKLSKENSLITQFTSFVAVEKRDEN 1184
            H LAARA+IRD+E     E E      ++   S  +  SK  ++I+++T+FV V+     
Sbjct: 852  HHLAARAIIRDFEQLAEREGEIEQGSNRRYQVS-ALHTSKACNIISKYTAFVPVDVSKSR 910

Query: 1185 ESP----FPDIPKVSELIAKEDVDFLPYMSWQGEPQEAVRNQSLLASSEWP 1231
              P    +P+      ++    +       W+G      R Q++L     P
Sbjct: 911  YLPTVVEYPNSGAALRMLGSRAL----AQQWRGTSSGFGRPQTMLGEDSAP 957


>gi|110825963 poly (ADP-ribose) polymerase family, member 2 isoform
           2 [Homo sapiens]
          Length = 570

 Score =  103 bits (258), Expect = 1e-21
 Identities = 90/351 (25%), Positives = 148/351 (42%), Gaps = 52/351 (14%)

Query: 257 STLSQEVSDLVEMIWAEALGHLEHMLLK--------PVNRISLNDVSKAEGILLLVKAAL 308
           S L   V +L+++I    +  +E M+++        P+ ++++  +      L  ++  +
Sbjct: 219 SQLDLRVQELIKLICN--VQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCI 276

Query: 309 KNGETAEQLQKMMTEFYRLIPHK---GTMPKEVNLGLLAKKADLCQLIRDM---VNVCET 362
           + G+    L +   EFY  IPH     T P       L++K  L + + D+   + + +T
Sbjct: 277 RAGQHGRALMEACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKT 336

Query: 363 NLSKPNPPSLAKYRALRCKIEHVEQNTEEFLRVRKEVLQNH---HSKSPVDVLQIFRVGR 419
            L  P  P    YR L C +  ++  + EF  + + +   H   HS   + +L +F V +
Sbjct: 337 ELQSPEHPLDQHYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEK 396

Query: 420 VNETTEFLSKLGNVRPLLHGSPVQNIVGILCRGL-LLPKVVEDRGVQRTDVGNLGSGIYF 478
             E   F   L N   L HGS + N VGIL  GL + P      G         G GIYF
Sbjct: 397 DGEKEAFREDLHNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYM------FGKGIYF 450

Query: 479 SDSLSTSIKYSHPGETDGTRLLLICDVALGKCMDLHEKDFSLTEAPPGYDSVHGVSQTAS 538
           +D  S S  Y        T LLL+ +VALG+C +L E +        G  S  G+ + A 
Sbjct: 451 ADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAP 510

Query: 539 VTTDF--------------------------EDDEFVVYKTNQVKMKYIIK 563
            +  F                            +E++VY  NQV+M+Y++K
Sbjct: 511 SSAHFVTLNGSTVPLGPASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLK 561


>gi|110825961 poly (ADP-ribose) polymerase family, member 2 isoform
           1 [Homo sapiens]
          Length = 583

 Score =  103 bits (258), Expect = 1e-21
 Identities = 90/351 (25%), Positives = 148/351 (42%), Gaps = 52/351 (14%)

Query: 257 STLSQEVSDLVEMIWAEALGHLEHMLLK--------PVNRISLNDVSKAEGILLLVKAAL 308
           S L   V +L+++I    +  +E M+++        P+ ++++  +      L  ++  +
Sbjct: 232 SQLDLRVQELIKLICN--VQAMEEMMMEMKYNTKKAPLGKLTVAQIKAGYQSLKKIEDCI 289

Query: 309 KNGETAEQLQKMMTEFYRLIPHK---GTMPKEVNLGLLAKKADLCQLIRDM---VNVCET 362
           + G+    L +   EFY  IPH     T P       L++K  L + + D+   + + +T
Sbjct: 290 RAGQHGRALMEACNEFYTRIPHDFGLRTPPLIRTQKELSEKIQLLEALGDIEIAIKLVKT 349

Query: 363 NLSKPNPPSLAKYRALRCKIEHVEQNTEEFLRVRKEVLQNH---HSKSPVDVLQIFRVGR 419
            L  P  P    YR L C +  ++  + EF  + + +   H   HS   + +L +F V +
Sbjct: 350 ELQSPEHPLDQHYRNLHCALRPLDHESYEFKVISQYLQSTHAPTHSDYTMTLLDLFEVEK 409

Query: 420 VNETTEFLSKLGNVRPLLHGSPVQNIVGILCRGL-LLPKVVEDRGVQRTDVGNLGSGIYF 478
             E   F   L N   L HGS + N VGIL  GL + P      G         G GIYF
Sbjct: 410 DGEKEAFREDLHNRMLLWHGSRMSNWVGILSHGLRIAPPEAPITGYM------FGKGIYF 463

Query: 479 SDSLSTSIKYSHPGETDGTRLLLICDVALGKCMDLHEKDFSLTEAPPGYDSVHGVSQTAS 538
           +D  S S  Y        T LLL+ +VALG+C +L E +        G  S  G+ + A 
Sbjct: 464 ADMSSKSANYCFASRLKNTGLLLLSEVALGQCNELLEANPKAEGLLQGKHSTKGLGKMAP 523

Query: 539 VTTDF--------------------------EDDEFVVYKTNQVKMKYIIK 563
            +  F                            +E++VY  NQV+M+Y++K
Sbjct: 524 SSAHFVTLNGSTVPLGPASDTGILNPDGYTLNYNEYIVYNPNQVRMRYLLK 574


>gi|158634482 poly (ADP-ribose) polymerase family, member 3 isoform
           b [Homo sapiens]
          Length = 533

 Score = 79.0 bits (193), Expect = 4e-14
 Identities = 88/421 (20%), Positives = 174/421 (41%), Gaps = 75/421 (17%)

Query: 209 EDASEYFENYIEELKKQGFLLREHFTPEATQLASEQLQA----------------LLLEE 252
           EDA + FE    E  K  +  R+HF     +    ++QA                  + +
Sbjct: 119 EDAKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTK 178

Query: 253 VMNSSTLSQEVSDLVEMIWAEALGHLEHMLLK------PVNRISLNDVSKAEGILLLVKA 306
            +   +L      L+  I+++ +      L+       P+ ++S   +++    L  ++ 
Sbjct: 179 RVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEE 238

Query: 307 ALKNG-ETAEQLQKMMTEFYRLIPHK--GTMPKEVNLG-LLAKKADLCQLIRDM------ 356
           ALK   +  + L+++ + FY +IPH    + P  +N   LL  K D+  ++ D+      
Sbjct: 239 ALKGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQAL 298

Query: 357 --VNVCETNLSKPNPPSLAKYRALRCKIEHVEQNTEEFLRVRKEVLQNHHSKSPVDVLQI 414
             V+  E  + +   P    Y+ L+C+++ ++    E+  ++  + Q   +     +  I
Sbjct: 299 QAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHI 358

Query: 415 FRVGRVNETTEFL--SKLGNVRPLLHGSPVQNIVGILCRGLLLPKVVEDRGVQRTDVGNL 472
           ++V +  E   F   SKLGN + L HG+ +  +  IL  GL   +++   G      G +
Sbjct: 359 WKVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGL---RIMPHSG------GRV 409

Query: 473 GSGIYFSDSLSTSIKYSHPGETDGTRL--LLICDVALGKCMDLHEKDFSLTEAPPGYDSV 530
           G GIYF+   S S  Y    +     +  + + +VALG+   ++  + SL   PPG+DSV
Sbjct: 410 GKGIYFASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSV 469

Query: 531 HGVSQTASVTTD----------------------------FEDDEFVVYKTNQVKMKYII 562
                T    T                             F   E+++Y+ +Q +++Y++
Sbjct: 470 IARGHTEPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLL 529

Query: 563 K 563
           +
Sbjct: 530 E 530


>gi|158634478 poly (ADP-ribose) polymerase family, member 3 isoform
           a [Homo sapiens]
          Length = 540

 Score = 79.0 bits (193), Expect = 4e-14
 Identities = 88/421 (20%), Positives = 174/421 (41%), Gaps = 75/421 (17%)

Query: 209 EDASEYFENYIEELKKQGFLLREHFTPEATQLASEQLQA----------------LLLEE 252
           EDA + FE    E  K  +  R+HF     +    ++QA                  + +
Sbjct: 126 EDAKKDFEKKFREKTKNNWAERDHFVSHPGKYTLIEVQAEDEAQEAVVKVDRGPVRTVTK 185

Query: 253 VMNSSTLSQEVSDLVEMIWAEALGHLEHMLLK------PVNRISLNDVSKAEGILLLVKA 306
            +   +L      L+  I+++ +      L+       P+ ++S   +++    L  ++ 
Sbjct: 186 RVQPCSLDPATQKLITNIFSKEMFKNTMALMDLDVKKMPLGKLSKQQIARGFEALEALEE 245

Query: 307 ALKNG-ETAEQLQKMMTEFYRLIPHK--GTMPKEVNLG-LLAKKADLCQLIRDM------ 356
           ALK   +  + L+++ + FY +IPH    + P  +N   LL  K D+  ++ D+      
Sbjct: 246 ALKGPTDGGQSLEELSSHFYTVIPHNFGHSQPPPINSPELLQAKKDMLLVLADIELAQAL 305

Query: 357 --VNVCETNLSKPNPPSLAKYRALRCKIEHVEQNTEEFLRVRKEVLQNHHSKSPVDVLQI 414
             V+  E  + +   P    Y+ L+C+++ ++    E+  ++  + Q   +     +  I
Sbjct: 306 QAVSEQEKTVEEVPHPLDRDYQLLKCQLQLLDSGAPEYKVIQTYLEQTGSNHRCPTLQHI 365

Query: 415 FRVGRVNETTEFL--SKLGNVRPLLHGSPVQNIVGILCRGLLLPKVVEDRGVQRTDVGNL 472
           ++V +  E   F   SKLGN + L HG+ +  +  IL  GL   +++   G      G +
Sbjct: 366 WKVNQEGEEDRFQAHSKLGNRKLLWHGTNMAVVAAILTSGL---RIMPHSG------GRV 416

Query: 473 GSGIYFSDSLSTSIKYSHPGETDGTRL--LLICDVALGKCMDLHEKDFSLTEAPPGYDSV 530
           G GIYF+   S S  Y    +     +  + + +VALG+   ++  + SL   PPG+DSV
Sbjct: 417 GKGIYFASENSKSAGYVIGMKCGAHHVGYMFLGEVALGREHHINTDNPSLKSPPPGFDSV 476

Query: 531 HGVSQTASVTTD----------------------------FEDDEFVVYKTNQVKMKYII 562
                T    T                             F   E+++Y+ +Q +++Y++
Sbjct: 477 IARGHTEPDPTQDTELELDGQQVVVPQGQPVPCPEFSSSTFSQSEYLIYQESQCRLRYLL 536

Query: 563 K 563
           +
Sbjct: 537 E 537


>gi|31542984 inter-alpha (globulin) inhibitor H4 [Homo sapiens]
          Length = 930

 Score = 69.7 bits (169), Expect = 2e-11
 Identities = 127/613 (20%), Positives = 237/613 (38%), Gaps = 60/613 (9%)

Query: 616  ASGNLVPLEDVHIKGRIIDTVAQVIVFQTYTNKSHVPIEAKYIFPLDDKAAVCGFEAFIN 675
            A  N + +  + +  R+    A  +V     N+++   EA +   L  KA +  F   I+
Sbjct: 28   AEKNGIDIYSLTVDSRVSSRFAHTVVTSRVVNRANTVQEATFQMELPKKAFITNFSMIID 87

Query: 676  GKHIVGEIKEKEEAQQEYLEAVTQGHGAYLMSQDAPDV--FTVSVGNLPPKAKVLIKITY 733
            G    G IKEK EAQ +Y  AV +G  A L+     ++  F VSV ++ P AK+  ++ Y
Sbjct: 88   GMTYPGIIKEKAEAQAQYSAAVAKGKSAGLVKATGRNMEQFQVSV-SVAPNAKITFELVY 146

Query: 734  ITELSILGTVGVFFMPATVAPWQQDKALNENLQDTVEKICIKEIGTKQSFSLTMSIEM-- 791
              E  +   +GV+ +   V P Q  K L  ++    E   I  + T+ +F     ++   
Sbjct: 147  --EELLKRRLGVYELLLKVRPQQLVKHLQMDIH-IFEPQGISFLETESTFMTNQLVDALT 203

Query: 792  ----PYVIEFIFSDTHELKQKRTDCKAVISTMEGSSLDSSGFSLHIGLSAAYLPRMWVEK 847
                       F  T   +QK  + +  +  ++G+ +    + +   +S   +       
Sbjct: 204  TWQNKTKAHIRFKPTLSQQQKSPEQQETV--LDGNLI--IRYDVDRAISGGSI------- 252

Query: 848  HPEKESEACMLVFQPDLDVDLPDLASESEVIICLDCSSSMEGVTFLQAKQIALHALSLVG 907
              + E+   +  F P+    +P       V+  +D S SM G    Q ++  +  L  + 
Sbjct: 253  --QIENGYFVHYFAPEGLTTMP-----KNVVFVIDKSGSMSGRKIQQTREALIKILDDLS 305

Query: 908  EKQKVNIIQFGTGYKELF-SYPKHITSNTMAAEFIMSATPTMGNTDFWKT-LRYLSLL-- 963
             + + N+I F T   +   S       N   A    +    +G T+     L  + LL  
Sbjct: 306  PRDQFNLIVFSTEATQWRPSLVPASAENVNKARSFAAGIQALGGTNINDAMLMAVQLLDS 365

Query: 964  ------YPARGSRNILLVSD-----GHLQDESLTLQLVKRSRPHTRLFACGIGSTANRHV 1012
                   P      I+L++D     G     S+   + +       LF  G G   +   
Sbjct: 366  SNQEERLPEGSVSLIILLTDGDPTVGETNPRSIQNNVREAVSGRYSLFCLGFGFDVSYAF 425

Query: 1013 LRILSQCGAGVFEYFNAKSKHSWRKQIEDQMTRLCSPSCHSVSVKWQQLNPDVPEALQAP 1072
            L  L+    G+    +  S  +   Q++D    + +P   +V+ ++   +  V E  Q  
Sbjct: 426  LEKLALDNGGLARRIHEDSDSA--LQLQDFYQEVANPLLTAVTFEYP--SNAVEEVTQNN 481

Query: 1073 AQVPSLFLNDRLLVYGFI----PHCTQATLCALI--QEKEFRTMVSTTELQ---KTTGTM 1123
             ++  LF    ++V G +    P    AT+   +  Q   F+T  S  E +   ++   +
Sbjct: 482  FRL--LFKGSEMVVAGKLQDRGPDVLTATVSGKLPTQNITFQTESSVAEQEAEFQSPKYI 539

Query: 1124 IHKLAARALIRDYEDGILHENETSHEMKKQTLKSLIIKLSKENSLITQFTSFVAVEKRDE 1183
             H    R         +L +  ++ +  +Q L++  + LS   S +T  TS V  +  D+
Sbjct: 540  FHNFMERLWAYLTIQQLLEQTVSASDADQQALRNQALNLSLAYSFVTPLTSMVVTKPDDQ 599

Query: 1184 NESPFPDIPKVSE 1196
             +S   + P   E
Sbjct: 600  EQSQVAEKPMEGE 612


>gi|133925809 inter-alpha (globulin) inhibitor H3 preproprotein [Homo
            sapiens]
          Length = 890

 Score = 51.6 bits (122), Expect = 7e-06
 Identities = 127/620 (20%), Positives = 231/620 (37%), Gaps = 69/620 (11%)

Query: 610  KAGLQDASGNLVPLEDVHIKGRIIDTVAQVIVFQTYTNKSHVPIEAKYIFPLDDKAAVCG 669
            K  L +   N + +    I  ++    A  +V     N++    E  +   L   A +  
Sbjct: 32   KRSLPEGVANGIEVYSTKINSKVTSRFAHNVVTMRAVNRADTAKEVSFDVELPKTAFITN 91

Query: 670  FEAFINGKHIVGEIKEKEEAQQEYLEAVTQGHGAYLMSQDAP--DVFTVSVGNLPPKAKV 727
            F   I+G    G +KEKE A+++Y +AV+QG  A L+       + FTVSV N+   +KV
Sbjct: 92   FTLTIDGVTYPGNVKEKEVAKKQYEKAVSQGKTAGLVKASGRKLEKFTVSV-NVAAGSKV 150

Query: 728  LIKITYITELSILGTVGVFFMPATVAPWQQDKALNENLQDTVEKICIKEIGTKQSFSLTM 787
              ++TY  E  +    G + M   V P Q  K     + D  E   I  +  + SF    
Sbjct: 151  TFELTY--EELLKRHKGKYEMYLKVQPKQLVKHFEIEV-DIFEPQGISMLDAEASFITND 207

Query: 788  SIEMPYVIEFIFSDTHELKQKRTDCKAVISTMEGSSLDSSGFSLHIGLSAAYLPRMWVEK 847
             +       F     H   +   D +    T   S L+          +  Y        
Sbjct: 208  LLGSALTKSFSGKKGHVSFKPSLDQQRSCPTCTDSLLNGD-------FTITYDVNRESPG 260

Query: 848  HPEKESEACMLVFQPDLDVDLPDLASESEVIICLDCSSSMEGVTFLQAKQIALHALSLVG 907
            + +  +   +  F P     LP       V   +D S SM G    Q K+  L  L  + 
Sbjct: 261  NVQIVNGYFVHFFAPQ---GLP--VVPKNVAFVIDISGSMAGRKLEQTKEALLRILEDMQ 315

Query: 908  EKQKVNIIQFGTGYKELFSYPKHIT----SNTMAAEFIMSATPTMGNTDFWK-TLRYLSL 962
            E+  +N I F     ++ ++ +H+      N   A   + +    G T+     LR +S+
Sbjct: 316  EEDYLNFILFS---GDVSTWKEHLVQATPENLQEARTFVKSMEDKGMTNINDGLLRGISM 372

Query: 963  L--------YPARGSRNILLVSDGHLQDESLTLQLVKRSRPHTR--------LFACGIGS 1006
            L         P R +  +++++DG   D ++     ++ + + R        L+  G G+
Sbjct: 373  LNKAREEHRIPERSTSIVIMLTDG---DANVGESRPEKIQENVRNAIGGKFPLYNLGFGN 429

Query: 1007 TANRHVLRILSQCGAGVFEYFNAKSKHSWRKQIEDQMTRLCSPSCHSVSVKWQQLNPDVP 1066
              N + L  ++    G        S      Q++     + +P    V +++ +    + 
Sbjct: 430  NLNYNFLENMALENHGFARRIYEDSDAD--LQLQGFYEEVANPLLTGVEMEYPE--NAIL 485

Query: 1067 EALQAPAQVPSLFLNDRLLVYGFIPHCTQATLCALIQ------EKEFRTMVSTTELQKTT 1120
            +  Q   Q    +    ++V G +      +  A ++      +  F   V   E++K  
Sbjct: 486  DLTQNTYQ--HFYDGSEIVVAGRLVDEDMNSFKADVKGHGATNDLTFTEEVDMKEMEKAL 543

Query: 1121 -------GTMIHKLAARALIRDYEDGILHENETSHEMKKQTLKSLIIKLSKENSLITQFT 1173
                   G  I +L A   I    + +L + + +H  +K+ L +  + LS +   +T  T
Sbjct: 544  QERDYIFGNYIERLWAYLTI----EQLLEKRKNAHGEEKENLTARALDLSLKYHFVTPLT 599

Query: 1174 SFVAVEKRD-ENESPFPDIP 1192
            S V  +  D E+E    D P
Sbjct: 600  SMVVTKPEDNEDERAIADKP 619


>gi|13376842 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
            polymerase 2 [Homo sapiens]
          Length = 1166

 Score = 47.8 bits (112), Expect = 9e-05
 Identities = 46/162 (28%), Positives = 68/162 (41%), Gaps = 30/162 (18%)

Query: 419  RVNETTEFLSKLGNVRPLLHGSPVQNIVGILCRGLLLPKVVEDRGVQRTDVGNLGSGIYF 478
            R  E +E      N R L HGSP  N +        + K  ++R       G  G+GIYF
Sbjct: 1012 RRKEVSEENHNHANERMLFHGSPFVNAI--------IHKGFDERHAYIG--GMFGAGIYF 1061

Query: 479  SDSLSTSIKYSHPGETDGT--------------RLLLICDVALGKCMDLHEKDFSLTEAP 524
            +++ S S +Y + G   GT              R LL C V LGK   L      +  +P
Sbjct: 1062 AENSSKSNQYVY-GIGGGTGCPVHKDRSCYICHRQLLFCRVTLGKSF-LQFSAMKMAHSP 1119

Query: 525  PGYDSVHGVSQTASVTTDFEDDEFVVYKTNQVKMKYIIKFSM 566
            PG+ SV G      +       E+V+Y+  Q   +Y+I + +
Sbjct: 1120 PGHHSVTGRPSVNGLAL----AEYVIYRGEQAYPEYLITYQI 1157


>gi|4505939 DNA-directed RNA polymerase II A [Homo sapiens]
          Length = 1970

 Score = 47.4 bits (111), Expect = 1e-04
 Identities = 54/195 (27%), Positives = 76/195 (38%), Gaps = 32/195 (16%)

Query: 1305 VSPWETSTSSFFPILAPAVGSYLPPTARAHSPASLSFASYRQVASFGSAAPPRQFDASQF 1364
            ++PW    +  +   +P+VGS + P A   SP++ S                   DAS F
Sbjct: 1517 MTPWNQGATPAYGAWSPSVGSGMTPGAAGFSPSAAS-------------------DASGF 1557

Query: 1365 SQGPVPGTCADWIPQSASCPTGPPQNPPSSPYCGIVFSGSSLSSAQSAPL---QHPGGFT 1421
            S    PG    W P     P  P    PSSPY        S S + ++P    + PGG+T
Sbjct: 1558 S----PGYSPAWSP----TPGSPGSPGPSSPYIPSPGGAMSPSYSPTSPAYEPRSPGGYT 1609

Query: 1422 TR-PSAGTFPELDSPQLHFSLPTDPDPIRGFGSYHPSASSPFHFQPSAASLTANLRLPMA 1480
             + PS        SP      PT P+      SY P++ S     PS  S T+    P +
Sbjct: 1610 PQSPSYSPTSPSYSPTSPSYSPTSPNYSPTSPSYSPTSPSYSPTSPS-YSPTSPSYSPTS 1668

Query: 1481 SALPEALCSQSRTTP 1495
             +      S S T+P
Sbjct: 1669 PSYSPTSPSYSPTSP 1683


>gi|87239981 tankyrase, TRF1-interacting ankyrin-related ADP-ribose
            polymerase [Homo sapiens]
          Length = 1327

 Score = 47.0 bits (110), Expect = 2e-04
 Identities = 46/162 (28%), Positives = 68/162 (41%), Gaps = 30/162 (18%)

Query: 419  RVNETTEFLSKLGNVRPLLHGSPVQNIVGILCRGLLLPKVVEDRGVQRTDVGNLGSGIYF 478
            R  E +E      N R L HGSP  N +        + K  ++R       G  G+GIYF
Sbjct: 1165 RQKEVSEENHNHHNERMLFHGSPFINAI--------IHKGFDERHAYIG--GMFGAGIYF 1214

Query: 479  SDSLSTSIKYSHPGETDGT--------------RLLLICDVALGKCMDLHEKDFSLTEAP 524
            +++ S S +Y + G   GT              R +L C V LGK   L      +  AP
Sbjct: 1215 AENSSKSNQYVY-GIGGGTGCPTHKDRSCYICHRQMLFCRVTLGKSF-LQFSTMKMAHAP 1272

Query: 525  PGYDSVHGVSQTASVTTDFEDDEFVVYKTNQVKMKYIIKFSM 566
            PG+ SV G      +       E+V+Y+  Q   +Y+I + +
Sbjct: 1273 PGHHSVIGRPSVNGLAY----AEYVIYRGEQAYPEYLITYQI 1310



 Score = 33.5 bits (75), Expect = 1.8
 Identities = 36/133 (27%), Positives = 52/133 (39%), Gaps = 13/133 (9%)

Query: 1295 PTATEPLFKKVSPWETSTSSFFPILAPAVGSYLP-------PTARAHSPASL---SFASY 1344
            P  +  L    +P   + S   P  +P  G  LP       P  R  SP  +   S  S 
Sbjct: 33   PPLSPGLAPGTTPASPTASGLAPFASPRHGLALPEGDGSRDPPDRPRSPDPVDGTSCCST 92

Query: 1345 RQVASFGSAAP--PRQFDASQFSQGPVP-GTCADWIPQSASCPTGPPQNPPSSPYCGIVF 1401
                   +AAP  P    +S     P P G+ ++  P S+S PT    + PSSP   +  
Sbjct: 93   TSTICTVAAAPVVPAVSTSSAAGVAPNPAGSGSNNSPSSSSSPTSSSSSSPSSPGSSLAE 152

Query: 1402 SGSSLSSAQSAPL 1414
            S  +   + +APL
Sbjct: 153  SPEAAGVSSTAPL 165


>gi|222352129 von Willebrand factor A domain containing 5B2 [Homo
            sapiens]
          Length = 1242

 Score = 46.6 bits (109), Expect = 2e-04
 Identities = 58/240 (24%), Positives = 102/240 (42%), Gaps = 26/240 (10%)

Query: 858  LVFQPDLDVDLPDLASES-EVIICLDCSSSMEGVTFLQAKQIALHALSLVGEKQKVNIIQ 916
            L F PDL      L + + E++  LD SS       +  K   + A+  +  +  +N+  
Sbjct: 335  LSFCPDLSSKPGHLGTATRELLFLLDSSS-------VAHKDAIVLAVKSLPPQTLINLAV 387

Query: 917  FGTGYKELFSYPKHITSNTMAAEFIMSATPTM----GNTDF-----WKTLRYLSLLYPAR 967
            FGT  + LF  P+    +  A + I  +  T+    G  D      W   +     YP +
Sbjct: 388  FGTLVQPLF--PESRPCSDDAVQLICESIETLQVPSGPPDVLAALDWAVGQPQHRAYPRQ 445

Query: 968  GSRNILLVSDGHLQDESLTLQLVKRSRPHTRLFACGIGSTANRHVLRILSQCGAGVFEYF 1027
                +L  +         TL+L++  R   R F+ G+G T ++ +L+ LS    G  + +
Sbjct: 446  --LFLLTAASPMAATTHRTLELMRWHRGTARCFSFGLGPTCHQ-LLQGLSALSRG--QAY 500

Query: 1028 NAKSKHSWRKQIEDQMTRLCSPSCHSVSVKWQQLNPDVPEALQAPAQVPSLFLNDRLLVY 1087
              +     +  +   + +   P+   +SV W    PD  EAL  P ++P+L+  D+LL Y
Sbjct: 501  FLRPGQRLQPMLVQALRKALEPALSDISVDW--FVPDTVEALLTPREIPALYPGDQLLGY 558



 Score = 37.7 bits (86), Expect = 0.097
 Identities = 20/82 (24%), Positives = 37/82 (45%)

Query: 621 VPLEDVHIKGRIIDTVAQVIVFQTYTNKSHVPIEAKYIFPLDDKAAVCGFEAFINGKHIV 680
           +PL D  ++         V    TY N    P++  +++PL +   V GFEA   G+ + 
Sbjct: 13  LPLTDSWVRACANGPCLSVRARLTYRNPQPQPVDGVFVYPLAEAEVVSGFEAEAAGRRVS 72

Query: 681 GEIKEKEEAQQEYLEAVTQGHG 702
            +++ +  +Q     A+  G G
Sbjct: 73  FQLQSRRRSQAACCRALGPGLG 94


>gi|156119625 inter-alpha (globulin) inhibitor H1 [Homo sapiens]
          Length = 911

 Score = 43.5 bits (101), Expect = 0.002
 Identities = 30/132 (22%), Positives = 61/132 (46%), Gaps = 3/132 (2%)

Query: 604 KTSSSTKAGLQDASGNLVPLEDVHIKGRIIDTVAQVIVFQTYTNKSHVPIEAKYIFPLDD 663
           ++ SS K    D + + V +  + +  ++    A  +V     N ++   E  +   +  
Sbjct: 34  RSKSSEKRQAVDTAVDGVFIRSLKVNCKVTSRFAHYVVTSQVVNTANEAREVAFDLEIPK 93

Query: 664 KAAVCGFEAFINGKHIVGEIKEKEEAQQEYLEAVTQGHGAYLM--SQDAPDVFTVSVGNL 721
            A +  F    +G   +G+IK+K  A ++Y +A   G  A L+  S    + FT+ +  +
Sbjct: 94  TAFISDFAVTADGNAFIGDIKDKVTAWKQYRKAAISGENAGLVRASGRTMEQFTIHL-TV 152

Query: 722 PPKAKVLIKITY 733
            P++KV  ++TY
Sbjct: 153 NPQSKVTFQLTY 164


>gi|228008410 BEN domain containing 4 isoform b [Homo sapiens]
          Length = 441

 Score = 42.0 bits (97), Expect = 0.005
 Identities = 48/153 (31%), Positives = 63/153 (41%), Gaps = 25/153 (16%)

Query: 1301 LFKKVSPWETSTSSFFPILAPAVGS-YLPPT------ARAHSPASLSFASYRQVASFGSA 1353
            ++K+ SP+  S    FP   PA+   Y  PT       RA  P    FA +  V+   S 
Sbjct: 17   IYKQRSPY--SVLKTFPSKRPALAKRYERPTLVELPHVRAPPPPPPPFAPHAAVSISSSE 74

Query: 1354 APPRQFDASQFSQGPVPGTCADWIPQSA-SCPTG--------PPQNPPSSPYCGIVFSGS 1404
             PP+QF A Q S  P PG  A     S+ SC           P Q PP+SP      + S
Sbjct: 75   PPPQQFQA-QSSYPPGPGRAAAAASSSSPSCTPATSQGHLRTPAQPPPASP------AAS 127

Query: 1405 SLSSAQSAPLQHPGGFTTRPSAGTFPELDSPQL 1437
            S SS  +     PG      + GT  +  S +L
Sbjct: 128  SSSSFAAVVRYGPGAAAAAGTGGTGSDSASLEL 160


>gi|148762950 BEN domain containing 4 isoform a [Homo sapiens]
          Length = 534

 Score = 42.0 bits (97), Expect = 0.005
 Identities = 48/153 (31%), Positives = 63/153 (41%), Gaps = 25/153 (16%)

Query: 1301 LFKKVSPWETSTSSFFPILAPAVGS-YLPPT------ARAHSPASLSFASYRQVASFGSA 1353
            ++K+ SP+  S    FP   PA+   Y  PT       RA  P    FA +  V+   S 
Sbjct: 17   IYKQRSPY--SVLKTFPSKRPALAKRYERPTLVELPHVRAPPPPPPPFAPHAAVSISSSE 74

Query: 1354 APPRQFDASQFSQGPVPGTCADWIPQSA-SCPTG--------PPQNPPSSPYCGIVFSGS 1404
             PP+QF A Q S  P PG  A     S+ SC           P Q PP+SP      + S
Sbjct: 75   PPPQQFQA-QSSYPPGPGRAAAAASSSSPSCTPATSQGHLRTPAQPPPASP------AAS 127

Query: 1405 SLSSAQSAPLQHPGGFTTRPSAGTFPELDSPQL 1437
            S SS  +     PG      + GT  +  S +L
Sbjct: 128  SSSSFAAVVRYGPGAAAAAGTGGTGSDSASLEL 160


>gi|239751637 PREDICTED: hypothetical protein FLJ22184 [Homo sapiens]
          Length = 1124

 Score = 41.6 bits (96), Expect = 0.007
 Identities = 44/153 (28%), Positives = 58/153 (37%), Gaps = 15/153 (9%)

Query: 1315 FFPILAPAVGSYLPPTARAHSPASLSFASYRQVASFGSAAPPRQFDASQFSQGPVPGTCA 1374
            F P  +P V     P ++A  P SL+ A   QV     A+PP    A+   Q P P    
Sbjct: 677  FSPPASPPVSPSATPPSQA--PPSLA-APPLQVPPSPPASPPMSPSATPPPQAPPPLAAP 733

Query: 1375 DWIPQSASCPTGPPQNPPSSPYC------GIVFSGSSLSSAQSAPLQHPGGFTTRPSAGT 1428
                     P  PP +PP SP          + +   L    S P   P     +P    
Sbjct: 734  P-----LQVPPSPPASPPMSPSATPPPRVPPLLAAPPLQVPPSPPASLPMSPLAKPPPQA 788

Query: 1429 FPELDSPQLHFSLPTDPDPIRGFGSYHPSASSP 1461
             P L +P L  +LP+ P    G   + PSAS P
Sbjct: 789  PPALATPPLQ-ALPSPPASFPGQAPFSPSASLP 820



 Score = 34.3 bits (77), Expect = 1.1
 Identities = 54/213 (25%), Positives = 73/213 (34%), Gaps = 6/213 (2%)

Query: 1292 SCKPTAT-EPLFKKVSPWETSTSSFFPILAPAVGSYLPPTARAHSPASLSFASYRQVASF 1350
            S  P AT  P   K  P     ++  P+ A    S    T    +P S S     Q    
Sbjct: 300  SSSPLATPSPSGTKARPVPPPDNAATPLPATLPPSPPLATPLPLAPPSPSAPPSLQTLPS 359

Query: 1351 GSAAPPRQFDASQFSQGPVPGTCADWIP--QSASCPTGPPQNPPSSPYCGIVFSGSSLSS 1408
              A PP Q   S  +           IP  Q     T P    P SP    + S  + +S
Sbjct: 360  PPATPPSQAPPSMTTPPMQAPPSLQTIPPIQVPHSLTSPSLQAPPSPLA--LSSLQATTS 417

Query: 1409 AQSAPLQHPGGFTTRPSAGTFPELDSPQLHFSLPTDPDPIRGFGSYHPSASSPFHFQPSA 1468
              S  LQ    F T     T   L SP    S P D  P++   S   S        P+ 
Sbjct: 418  LGSPTLQATHSFLTMSPRQTQASLTSPSRPASTPPDSPPLQAPLSLPASPPLQTSLSPAV 477

Query: 1469 ASLTANLRLPMASALPEALCSQSRTTPVDLCLL 1501
            + L++ L +    AL  +L S S   P+   ++
Sbjct: 478  SPLSSPLTIHPLQAL-SSLASHSPQAPLSSLIM 509


>gi|118498362 kinectin 1 isoform b [Homo sapiens]
          Length = 1306

 Score = 41.2 bits (95), Expect = 0.009
 Identities = 56/252 (22%), Positives = 98/252 (38%), Gaps = 32/252 (12%)

Query: 79   KSIREKRLLDVKNYDPYKPLDITPPPDQKASSSEVKTEGLCPDSATEEEDTVELTEFGMQ 138
            + + E  LL V N +    L IT    +  +  + K E +    A  EE   +L   G  
Sbjct: 814  EELLEAELLKVANKEKTVQLSITSKVQELQNLLKGKEEQMNTMKAVLEEKEKDLANTGKW 873

Query: 139  NVEIPHLPQDF-----EVAKYNTLEKVGMEGGQEAVVVELQCSRDSRDCPFLISSHFLLD 193
              ++    +       EVA++N  E       +E  +V  +   + +    ++      +
Sbjct: 874  LQDLQEENESLKAHVQEVAQHNLKEASSASQFEELEIVLKEKENELKRLEAMLKER---E 930

Query: 194  DGMETRRQFAIKKTSEDASEYFENYIEELKKQGFLLREHFTPEATQLASEQLQALLLEEV 253
              + ++ Q  + +  +D ++ F++ IE+LK+Q +     F P       E+L  ++ E  
Sbjct: 931  SDLSSKTQ--LLQDVQDENKLFKSQIEQLKQQNYQQASSFPPH------EELLKVISERE 982

Query: 254  MNSSTLSQEV--------------SDLVEMIW--AEALGHLEHMLLKPVNRISLNDVSKA 297
               S L  E+              +DL E  W   EAL   E ML   VN+ S     + 
Sbjct: 983  KEISGLWNELDSLKDAVEHQRKKNNDLREKNWEAMEALASTEKMLQDKVNKTSKERQQQV 1042

Query: 298  EGILLLVKAALK 309
            E + L  K  LK
Sbjct: 1043 EAVELEAKEVLK 1054


>gi|38348336 inter-alpha (globulin) inhibitor H5-like [Homo sapiens]
          Length = 1313

 Score = 40.4 bits (93), Expect = 0.015
 Identities = 31/106 (29%), Positives = 44/106 (41%), Gaps = 10/106 (9%)

Query: 598 YQLPDAKTSSSTKAGLQDASGNLVPLEDVHIKGRIIDTVAQVIVFQTYTNKSHVPIEAKY 657
           YQ P    SSSTK  +   S          ++  ++   A  +V     N      EA +
Sbjct: 22  YQGPPVPASSSTKLLMTSYS----------MRSTVVSRYAHTLVTSVLFNPHAEAHEAIF 71

Query: 658 IFPLDDKAAVCGFEAFINGKHIVGEIKEKEEAQQEYLEAVTQGHGA 703
              L   A +  F   IN K  + E+KEK +A++ Y EA  QG  A
Sbjct: 72  DLDLPHLAFISNFTMTINNKVYIAEVKEKHQAKKIYEEAHQQGKTA 117


>gi|55750053 atrophin-1 [Homo sapiens]
          Length = 1190

 Score = 40.4 bits (93), Expect = 0.015
 Identities = 33/113 (29%), Positives = 46/113 (40%), Gaps = 7/113 (6%)

Query: 1319 LAPAVGSYLP-PTARAHSPASLSFASYRQVASFGSAAPPRQFDASQFSQGPVPGTCADWI 1377
            ++P++GS  P P   AH P   S  SY Q    G         +S  SQG  P  C+   
Sbjct: 532  MSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYP--CSH-- 587

Query: 1378 PQSASCPTGPPQNPPSSPYCGIVFSGSSLSSAQSAPLQHPGGFTTRPSAGTFP 1430
            P  +  P G P   P  P   +  S ++LS+  +     P G+ T    G  P
Sbjct: 588  PSPSQGPQGAPY--PFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPP 638


>gi|55750041 atrophin-1 [Homo sapiens]
          Length = 1190

 Score = 40.4 bits (93), Expect = 0.015
 Identities = 33/113 (29%), Positives = 46/113 (40%), Gaps = 7/113 (6%)

Query: 1319 LAPAVGSYLP-PTARAHSPASLSFASYRQVASFGSAAPPRQFDASQFSQGPVPGTCADWI 1377
            ++P++GS  P P   AH P   S  SY Q    G         +S  SQG  P  C+   
Sbjct: 532  MSPSLGSLRPYPPGPAHLPPPHSQVSYSQAGPNGPPVSSSSNSSSSTSQGSYP--CSH-- 587

Query: 1378 PQSASCPTGPPQNPPSSPYCGIVFSGSSLSSAQSAPLQHPGGFTTRPSAGTFP 1430
            P  +  P G P   P  P   +  S ++LS+  +     P G+ T    G  P
Sbjct: 588  PSPSQGPQGAPY--PFPPVPTVTTSSATLSTVIATVASSPAGYKTASPPGPPP 638


>gi|150417989 cyclin K isoform 1 [Homo sapiens]
          Length = 580

 Score = 40.0 bits (92), Expect = 0.020
 Identities = 43/153 (28%), Positives = 53/153 (34%), Gaps = 7/153 (4%)

Query: 1317 PILAPAVGSYLPPTARAHSPASLSFASYRQVASFGSAAPPRQFDASQFSQGPVPGTCADW 1376
            P   P + +  PP   AH P           A+ G A PP   DA+   +  +P      
Sbjct: 352  PPKIPKIETTHPPLPPAHPPPD---RKPPLAAALGEAEPPGPVDATDLPKVQIPPPAHPA 408

Query: 1377 -IPQSASCPTGPPQNPPSSPYCGIVFSGSSLSSAQSAPLQHPGGFTTRPSAGTFPELDSP 1435
             + Q    P  PP  PPSS   G+  + S +S      LQ     T  PS G  P    P
Sbjct: 409  PVHQPPPLPHRPPPPPPSSYMTGMSTTSSYMSGEGYQSLQSMMK-TEGPSYGALPPAYGP 467

Query: 1436 QLHFSLPTDPDPIRGFGSYHPSASSPFHFQPSA 1468
              H  LP  P          P    P  F P A
Sbjct: 468  PAH--LPYHPHVYPPNPPPPPVPPPPASFPPPA 498


>gi|58530876 melanoma antigen family C, 1 [Homo sapiens]
          Length = 1142

 Score = 39.7 bits (91), Expect = 0.026
 Identities = 63/240 (26%), Positives = 92/240 (38%), Gaps = 32/240 (13%)

Query: 1308 WETSTSSF-FPILAPA----VGSYLPPTARAHSPASLS----FASYRQVASFGSAAPPRQ 1358
            WE S S   FP   P       S   P +   S  SLS    F    Q    G A  P Q
Sbjct: 717  WEDSLSPLHFPQFPPQGEDFQSSLQSPVSICSSSTSLSLPQSFPESPQSPPEGPAQSPLQ 776

Query: 1359 FDASQFSQGPVPGTCADWIPQSASCPTGPPQNPPSSPYCGIVF---SGSSLSSAQSAPLQ 1415
               S F       T A  +  S   P  PP+ P  SP    V    S +S S +QS+P+ 
Sbjct: 777  RPVSSFFSY----TLASLLQSSHESPQSPPEGPAQSPLQSPVSSFPSSTSSSLSQSSPVS 832

Query: 1416 HPGGFTTRPSAGTFPE--LDSPQLHFSLPTDPDPIRGFGSYHPSASSPF-HFQPSAASLT 1472
                 T+   + + PE  L SP + FS  T   P      +   +SSP   +  S+ +L 
Sbjct: 833  SFPSSTSSSLSKSSPESPLQSPVISFSSSTSLSP------FSEESSSPVDEYTSSSDTLL 886

Query: 1473 ANLRLPMASALPEALCSQSRTTPVDLCLLEESVGSLEGSRCPVFAFQSSDTESDELSEVL 1532
             +  L  + +L E       + P+    L+E V  L       +  +   T+++ L+ V+
Sbjct: 887  ESDSLTDSESLIE-------SEPLFTYTLDEKVDELARFLLLKYQVKQPITKAEMLTNVI 939


>gi|18959210 WIRE protein [Homo sapiens]
          Length = 440

 Score = 38.5 bits (88), Expect = 0.057
 Identities = 44/140 (31%), Positives = 58/140 (41%), Gaps = 22/140 (15%)

Query: 1328 PPTARAHSPASLSFASYRQVASFGSAAPPRQFDASQFSQGPVPGTCADWI-PQSASCPTG 1386
            PP  RA++P +        +    S AP          + P+P T    + P     P  
Sbjct: 181  PPGRRANAPPT-------PLPMHSSKAPAYN------REKPLPPTPGQRLHPGREGPPAP 227

Query: 1387 PPQNPPSSPY-CGIVFSGSSLSSAQSAPLQHPGGFTTRPSAGT---FPELDSPQLHFSLP 1442
            PP  PP SP       SG SL+     P + P G    PS+ T    PEL  PQ H SL 
Sbjct: 228  PPVKPPPSPVNIRTGPSGQSLAPPPP-PYRQPPGVPNGPSSPTNESAPEL--PQRHNSLH 284

Query: 1443 TD-PDPIRGFGSYHPSASSP 1461
               P P+RG     P+++SP
Sbjct: 285  RKTPGPVRGLAPPPPTSASP 304


>gi|112382226 atrophin-1 like protein isoform b [Homo sapiens]
          Length = 1012

 Score = 37.7 bits (86), Expect = 0.097
 Identities = 48/168 (28%), Positives = 61/168 (36%), Gaps = 22/168 (13%)

Query: 1319 LAPAVGSYLPPTARAHSPASLSFASYRQVASFGSAAPPRQFDASQFSQGPVPGTCADWIP 1378
            + PA  S  P T +  +P     A+   V   GS    +  +  Q    PVP T     P
Sbjct: 193  VTPAPSSAPPGTPQLPTPGPTPSAT--AVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAP 250

Query: 1379 QSASCPTGPPQ-NPPSSPYCGIVFSGSSLSSAQSAPLQHPGGFTTRPSAGTFPELDSPQL 1437
              A  P  PP  +PP  P             +   PLQ   G   +PSA   P    P L
Sbjct: 251  --ALHPQRPPSPHPPPHP-------------SPHPPLQPLTGSAGQPSA---PSHAQPPL 292

Query: 1438 HFSLPTDPDPIR-GFGSYHPSASSPFHFQPSAASLTANLRLPMASALP 1484
            H   P  P  ++ G    HP    PF   P A+   A L    A+A P
Sbjct: 293  HGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYP 340


>gi|112382224 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score = 37.7 bits (86), Expect = 0.097
 Identities = 48/168 (28%), Positives = 61/168 (36%), Gaps = 22/168 (13%)

Query: 1319 LAPAVGSYLPPTARAHSPASLSFASYRQVASFGSAAPPRQFDASQFSQGPVPGTCADWIP 1378
            + PA  S  P T +  +P     A+   V   GS    +  +  Q    PVP T     P
Sbjct: 747  VTPAPSSAPPGTPQLPTPGPTPSAT--AVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAP 804

Query: 1379 QSASCPTGPPQ-NPPSSPYCGIVFSGSSLSSAQSAPLQHPGGFTTRPSAGTFPELDSPQL 1437
              A  P  PP  +PP  P             +   PLQ   G   +PSA   P    P L
Sbjct: 805  --ALHPQRPPSPHPPPHP-------------SPHPPLQPLTGSAGQPSA---PSHAQPPL 846

Query: 1438 HFSLPTDPDPIR-GFGSYHPSASSPFHFQPSAASLTANLRLPMASALP 1484
            H   P  P  ++ G    HP    PF   P A+   A L    A+A P
Sbjct: 847  HGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYP 894


>gi|112382216 atrophin-1 like protein isoform a [Homo sapiens]
          Length = 1566

 Score = 37.7 bits (86), Expect = 0.097
 Identities = 48/168 (28%), Positives = 61/168 (36%), Gaps = 22/168 (13%)

Query: 1319 LAPAVGSYLPPTARAHSPASLSFASYRQVASFGSAAPPRQFDASQFSQGPVPGTCADWIP 1378
            + PA  S  P T +  +P     A+   V   GS    +  +  Q    PVP T     P
Sbjct: 747  VTPAPSSAPPGTPQLPTPGPTPSAT--AVPPQGSPTASQAPNQPQAPTAPVPHTHIQQAP 804

Query: 1379 QSASCPTGPPQ-NPPSSPYCGIVFSGSSLSSAQSAPLQHPGGFTTRPSAGTFPELDSPQL 1437
              A  P  PP  +PP  P             +   PLQ   G   +PSA   P    P L
Sbjct: 805  --ALHPQRPPSPHPPPHP-------------SPHPPLQPLTGSAGQPSA---PSHAQPPL 846

Query: 1438 HFSLPTDPDPIR-GFGSYHPSASSPFHFQPSAASLTANLRLPMASALP 1484
            H   P  P  ++ G    HP    PF   P A+   A L    A+A P
Sbjct: 847  HGQGPPGPHSLQAGPLLQHPGPPQPFGLPPQASQGQAPLGTSPAAAYP 894


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.133    0.391 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 67,099,268
Number of Sequences: 37866
Number of extensions: 3192081
Number of successful extensions: 10521
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 20
Number of HSP's successfully gapped in prelim test: 142
Number of HSP's that attempted gapping in prelim test: 10215
Number of HSP's gapped (non-prelim): 390
length of query: 1724
length of database: 18,247,518
effective HSP length: 116
effective length of query: 1608
effective length of database: 13,855,062
effective search space: 22278939696
effective search space used: 22278939696
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 69 (31.2 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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