Search of human proteins with 105990528

Search of human proteins with 105990528

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|105990528 hairy/enhancer-of-split related with YRPW motif 1
isoform a [Homo sapiens]
         (304 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|105990528 hairy/enhancer-of-split related with YRPW motif 1 i...   608   e-174
gi|105990526 hairy/enhancer-of-split related with YRPW motif 1 i...   603   e-173
gi|6912414 hairy/enhancer-of-split related with YRPW motif 2 [Ho...   292   2e-79
gi|7657154 hairy/enhancer-of-split related with YRPW motif-like ...   212   4e-55
gi|5031763 hairy and enhancer of split 1 [Homo sapiens]                94   1e-19
gi|10863967 hairy and enhancer of split 4 isoform 2 [Homo sapiens]     91   2e-18
gi|216548627 hairy and enhancer of split 4 isoform 1 [Homo sapiens]    87   1e-17
gi|71274142 HES/HEY-like transcription factor [Homo sapiens]           81   1e-15
gi|145207994 hairy and enhancer of split 7 [Homo sapiens]              70   3e-12
gi|13540521 basic helix-loop-helix domain containing, class B, 3...    69   7e-12
gi|21361763 hairy and enhancer of split 6 isoform a [Homo sapiens]     65   7e-11
gi|218751874 hairy and enhancer of split 6 isoform b [Homo sapiens]    65   1e-10
gi|58219048 hairy and enhancer of split 5 [Homo sapiens]               62   5e-10
gi|63055047 hairy and enhancer of split homolog 2 [Homo sapiens]       62   6e-10
gi|24586667 transcription factor-like protein 4 isoform gamma [H...    52   8e-07
gi|38201612 transcription factor-like protein 4 isoform beta [Ho...    51   1e-06
gi|4503299 basic helix-loop-helix family, member e40 [Homo sapiens]    51   1e-06
gi|71852580 aryl hydrocarbon receptor nuclear translocator-like ...    46   4e-05
gi|42716311 aryl hydrocarbon receptor nuclear translocator-like ...    46   4e-05
gi|38201614 transcription factor-like protein 4 isoform alpha [H...    46   5e-05
gi|71852582 aryl hydrocarbon receptor nuclear translocator-like ...    45   8e-05
gi|66912172 hairy and enhancer of split 3 [Homo sapiens]               45   8e-05
gi|31745180 aryl hydrocarbon receptor nuclear translocator-like ...    42   9e-04
gi|52630419 sterol regulatory element binding transcription fact...    40   0.003
gi|22547195 sterol regulatory element binding transcription fact...    40   0.003
gi|66529407 tensin [Homo sapiens]                                      39   0.004
gi|46877105 upstream stimulatory factor 2 isoform 2 [Homo sapiens]     38   0.013
gi|4507847 upstream stimulatory factor 2 isoform 1 [Homo sapiens]      38   0.013
gi|27477113 sterol regulatory element-binding transcription fact...    37   0.017
gi|8659574 transcription factor E3 [Homo sapiens]                      37   0.022

>gi|105990528 hairy/enhancer-of-split related with YRPW motif 1
           isoform a [Homo sapiens]
          Length = 304

 Score =  608 bits (1569), Expect = e-174
 Identities = 304/304 (100%), Positives = 304/304 (100%)

Query: 1   MKRAHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKR 60
           MKRAHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKR
Sbjct: 1   MKRAHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKR 60

Query: 61  RRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAM 120
           RRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAM
Sbjct: 61  RRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAM 120

Query: 121 DYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLGHIPW 180
           DYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLGHIPW
Sbjct: 121 DYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLGHIPW 180

Query: 181 GTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGSLGPV 240
           GTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGSLGPV
Sbjct: 181 GTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGSLGPV 240

Query: 241 LPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRPWGTE 300
           LPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRPWGTE
Sbjct: 241 LPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRPWGTE 300

Query: 301 IGAF 304
           IGAF
Sbjct: 301 IGAF 304


>gi|105990526 hairy/enhancer-of-split related with YRPW motif 1
           isoform b [Homo sapiens]
          Length = 308

 Score =  603 bits (1554), Expect = e-173
 Identities = 304/308 (98%), Positives = 304/308 (98%), Gaps = 4/308 (1%)

Query: 1   MKRAHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKR 60
           MKRAHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKR
Sbjct: 1   MKRAHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKR 60

Query: 61  RRDRINNSLSELRRLVPSAFEKQ----GSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAH 116
           RRDRINNSLSELRRLVPSAFEKQ    GSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAH
Sbjct: 61  RRDRINNSLSELRRLVPSAFEKQVMEQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAH 120

Query: 117 ALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLG 176
           ALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLG
Sbjct: 121 ALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLG 180

Query: 177 HIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGS 236
           HIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGS
Sbjct: 181 HIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGS 240

Query: 237 LGPVLPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRP 296
           LGPVLPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRP
Sbjct: 241 LGPVLPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALSPSAPTQAANLGKPYRP 300

Query: 297 WGTEIGAF 304
           WGTEIGAF
Sbjct: 301 WGTEIGAF 308


>gi|6912414 hairy/enhancer-of-split related with YRPW motif 2 [Homo
           sapiens]
          Length = 337

 Score =  292 bits (748), Expect = 2e-79
 Identities = 182/336 (54%), Positives = 220/336 (65%), Gaps = 42/336 (12%)

Query: 7   EYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKRRRDRIN 66
           E ++S+S++DETI+V  E+     + SS +   SPTT+SQI+ARK+RRGIIEKRRRDRIN
Sbjct: 6   EETTSESDMDETIDVGSENNYSGQSTSSVIRLNSPTTTSQIMARKKRRGIIEKRRRDRIN 65

Query: 67  NSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAMDYRSLG 126
           NSLSELRRLVP+AFEKQGSAKLEKAEILQMTVDHLKML   GGKGYFDAHALAMD+ S+G
Sbjct: 66  NSLSELRRLVPTAFEKQGSAKLEKAEILQMTVDHLKMLQATGGKGYFDAHALAMDFMSIG 125

Query: 127 FRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGA------HAGLGHIPW 180
           FRECL EVARYLS +EGLD+SDPLRVRLVSHL+  A+QREAA+        H  L    W
Sbjct: 126 FRECLTEVARYLSSVEGLDSSDPLRVRLVSHLSTCATQREAAAMTSSMAHHHHPLHPHHW 185

Query: 181 GTVFGHHPHIAHPLLLPQNGHGNAGT-----TASPTEPHHQGRLGS---AHPEAPALRAP 232
              F H P     LL P   H +  T     T S   P H   L +   AH ++ ALR P
Sbjct: 186 AAAFHHLP---AALLQPNGLHASESTPCRLSTTSEVPPAHGSALLTATFAHADS-ALRMP 241

Query: 233 PSGSLGP-VLPVVTSASKLSPPLLSSVASLSA----FPFSF-GSFHLLSPN--------- 277
            +GS+ P V P+ TS   LS  + ++ A+ +A    FP SF G+F +L PN         
Sbjct: 242 STGSVAPCVPPLSTSLLSLSATVHAAAAAATAAAHSFPLSFAGAFPMLPPNAAAAVAAAT 301

Query: 278 ALSP-------SAP--TQAANLGKPYRPWGTEIGAF 304
           A+SP       S+P  T +    KPYRPWGTE+GAF
Sbjct: 302 AISPPLSVSATSSPQQTSSGTNNKPYRPWGTEVGAF 337


>gi|7657154 hairy/enhancer-of-split related with YRPW motif-like
           [Homo sapiens]
          Length = 328

 Score =  212 bits (539), Expect = 4e-55
 Identities = 153/345 (44%), Positives = 195/345 (56%), Gaps = 58/345 (16%)

Query: 1   MKRAHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKR 60
           MKR   E S SD E D  I+V +E     G LS     +S  +SSQ+ ARK+RRGIIEKR
Sbjct: 1   MKRPK-EPSGSDGESDGPIDVGQE-----GQLSQMARPLSTPSSSQMQARKKRRGIIEKR 54

Query: 61  RRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDAHALAM 120
           RRDRIN+SLSELRRLVP+AFEKQGS+KLEKAE+LQMTVDHLKMLH  GG G+FDA ALA+
Sbjct: 55  RRDRINSSLSELRRLVPTAFEKQGSSKLEKAEVLQMTVDHLKMLHATGGTGFFDARALAV 114

Query: 121 DYRSLGFRECLAEVARYLSIIEGLDA-SDPLRVRLVSHLNNYASQREAASGAHAGLGHIP 179
           D+RS+GFRECL EV RYL ++EG  + +DP+R+RL+SHLN+YA++ E +      L    
Sbjct: 115 DFRSIGFRECLTEVIRYLGVLEGPSSRADPVRIRLLSHLNSYAAEMEPSPTPTGPLAFPA 174

Query: 180 WGTVFGHH----PHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALR-APPS 234
           W   F H     P +++ L +        G   SP  P   G    A+P  PALR AP  
Sbjct: 175 WPWSFFHSCPGLPALSNQLAI-------LGRVPSPVLP---GVSSPAYP-IPALRTAPLR 223

Query: 235 GSLGPVLPV--------VTSASKLSPPLLSSVASLSAFPFSFG--SFH---LLSPNALSP 281
            + G +LP           S+++ + PL      +   P S    S H   LL  ++ +P
Sbjct: 224 RATGIILPARRNVLPSRGASSTRRARPLERPATPVPVAPSSRAARSSHIAPLLQSSSPTP 283

Query: 282 SAPTQAA--------------NLGKP-----YRPWG---TEIGAF 304
             PT +A                G+P     Y  W    TEIGAF
Sbjct: 284 PGPTGSAAYVAVPTPNSSSPGPAGRPAGAMLYHSWVSEITEIGAF 328


>gi|5031763 hairy and enhancer of split 1 [Homo sapiens]
          Length = 280

 Score = 94.0 bits (232), Expect = 1e-19
 Identities = 92/283 (32%), Positives = 127/283 (44%), Gaps = 58/283 (20%)

Query: 41  PTTSSQILARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGS--AKLEKAEILQMTV 98
           P T+S+   RK  + I+EKRRR RIN SLS+L+ L+  A +K  S  +KLEKA+IL+MTV
Sbjct: 28  PKTASE--HRKSSKPIMEKRRRARINESLSQLKTLILDALKKDSSRHSKLEKADILEMTV 85

Query: 99  DHLKMLHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHL 158
            HL+ L  A            +     GF EC+ EV R+LS  EG++    +R RL+ HL
Sbjct: 86  KHLRNLQRAQMTAALSTDPSVLGKYRAGFSECMNEVTRFLSTCEGVNTE--VRTRLLGHL 143

Query: 159 NNYASQREAASGAHAGLGHI-----------PWGTVFGHHPHIAHPLLLPQNGHGNAGTT 207
            N  +Q  A +  + G  H            P G    H P    P L+P  G       
Sbjct: 144 ANCMTQINAMT--YPGQPHPALQAPPPPPPGPGGP--QHAPFAPPPPLVPIPGGAAPPPG 199

Query: 208 ASPTEPHHQ-GRLGSAHPEAPALRAP--------PSGSL---GPVLPVVTSASKLSPPLL 255
            +P +   Q G           + AP        P+G+    GPV+PV TS S  S    
Sbjct: 200 GAPCKLGSQAGEAAKVFGGFQVVPAPDGQFAFLIPNGAFAHSGPVIPVYTSNSGTS---- 255

Query: 256 SSVASLSAFPFSFGSFHLLSPNALSPSA-PTQAANLGKPYRPW 297
                             + PNA+SPS+ P+  A+    +RPW
Sbjct: 256 ------------------VGPNAVSPSSGPSLTAD--SMWRPW 278


>gi|10863967 hairy and enhancer of split 4 isoform 2 [Homo sapiens]
          Length = 221

 Score = 90.5 bits (223), Expect = 2e-18
 Identities = 76/199 (38%), Positives = 96/199 (48%), Gaps = 21/199 (10%)

Query: 50  RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGS--AKLEKAEILQMTVDHLKMLHTA 107
           RK  + ++EKRRR RIN SL++L+ L+  A  K+ S  +KLEKA+IL+MTV HL+ L   
Sbjct: 35  RKSSKPVMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRSLRRV 94

Query: 108 GGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSH----LNNYAS 163
                  A    +     GF ECLAEV R+L+  EG+ A   +R RL+ H    L     
Sbjct: 95  QVTAALSADPAVLGKYRAGFHECLAEVNRFLAGCEGVPAD--VRSRLLGHLAACLRQLGP 152

Query: 164 QREAASGAHAGLGHIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAH 223
            R  AS + A     P   V+   P      LLP  G G     A P  P     L  A 
Sbjct: 153 SRRPASLSPAAPAEAPAPEVYAGRP------LLPSLG-GPFPLLAPPLLP----GLTRAL 201

Query: 224 PEAPALRAPPSGSLGPVLP 242
           P AP  RA P G  GP  P
Sbjct: 202 PAAP--RAGPQGPGGPWRP 218


>gi|216548627 hairy and enhancer of split 4 isoform 1 [Homo sapiens]
          Length = 247

 Score = 87.4 bits (215), Expect = 1e-17
 Identities = 74/193 (38%), Positives = 93/193 (48%), Gaps = 21/193 (10%)

Query: 56  IIEKRRRDRINNSLSELRRLVPSAFEKQGS--AKLEKAEILQMTVDHLKMLHTAGGKGYF 113
           ++EKRRR RIN SL++L+ L+  A  K+ S  +KLEKA+IL+MTV HL+ L         
Sbjct: 67  VMEKRRRARINESLAQLKTLILDALRKESSRHSKLEKADILEMTVRHLRSLRRVQVTAAL 126

Query: 114 DAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSH----LNNYASQREAAS 169
            A    +     GF ECLAEV R+L+  EG+ A   +R RL+ H    L      R  AS
Sbjct: 127 SADPAVLGKYRAGFHECLAEVNRFLAGCEGVPAD--VRSRLLGHLAACLRQLGPSRRPAS 184

Query: 170 GAHAGLGHIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPAL 229
            + A     P   V+   P      LLP  G G     A P  P     L  A P AP  
Sbjct: 185 LSPAAPAEAPAPEVYAGRP------LLPSLG-GPFPLLAPPLLP----GLTRALPAAP-- 231

Query: 230 RAPPSGSLGPVLP 242
           RA P G  GP  P
Sbjct: 232 RAGPQGPGGPWRP 244


>gi|71274142 HES/HEY-like transcription factor [Homo sapiens]
          Length = 327

 Score = 81.3 bits (199), Expect = 1e-15
 Identities = 83/275 (30%), Positives = 112/275 (40%), Gaps = 60/275 (21%)

Query: 56  IIEKRRRDRINNSLSELRRLVPSAFEKQG------------------------------- 84
           +IEKRRRDRIN  L+EL + VP A  KQG                               
Sbjct: 61  VIEKRRRDRINRCLNELGKTVPMALAKQGEPQEALAQIRSRVRSLVLSSATVPDQQALGR 120

Query: 85  ----------SAKLEKAEILQMTVDHLKMLHTAG-GKGYFDAHALA--MDYRSLGFRECL 131
                     S KLEKAEIL+MTV +L+ LH+A   +G   A  LA   +Y   G+ EC+
Sbjct: 121 CEGPFLLLQSSGKLEKAEILEMTVQYLRALHSADFPRGREKAELLAEFANYFHYGYHECM 180

Query: 132 AEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGLGHIPWGTVFGHHPHIA 191
             +  YL+ +E ++  D    R+++ L + A  R  A  A   LG +P    F +  H A
Sbjct: 181 KNLVHYLTTVERMETKDTKYARILAFLQSKA--RLGAEPAFPPLGSLP-EPDFSYQLHPA 237

Query: 192 HPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAPALRAPPSGSLGPVLPV-VTSASKL 250
            P      GH        P     QG      P  P     P+    P  PV + S ++ 
Sbjct: 238 GPEFA---GHSPGEAAVFP-----QGSGAGPFPWPPGAARSPALPYLPSAPVPLASPAQQ 289

Query: 251 SPPLLSSVASLSAFPFS-FGSFHLLSPNALSPSAP 284
             P L+ V  L     +  G  H   PNAL+   P
Sbjct: 290 HSPFLTPVQGLDRHYLNLIGHAH---PNALNLHTP 321


>gi|145207994 hairy and enhancer of split 7 [Homo sapiens]
          Length = 225

 Score = 69.7 bits (169), Expect = 3e-12
 Identities = 68/210 (32%), Positives = 86/210 (40%), Gaps = 27/210 (12%)

Query: 51  KRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQG--SAKLEKAEILQMTVDHLKMLHTAG 108
           K  + ++EKRRRDRIN SL ELR L+      Q   + KLEKAEIL+  V +L+      
Sbjct: 14  KMLKPLVEKRRRDRINRSLEELRLLLLERTRDQNLRNPKLEKAEILEFAVGYLRERSRVE 73

Query: 109 GKG-----YFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYAS 163
             G       DA ALA  Y S GFRECL  +A +       DAS   R +L S L+ Y  
Sbjct: 74  PPGVPRSPVQDAEALASCYLS-GFRECLLRLAAFAH-----DASPAARAQLFSALHGYLR 127

Query: 164 QREAASGAHAGLGHIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAH 223
            +             P        P    P L P       G       P HQG      
Sbjct: 128 PKP------------PRPKPVDPRPPAPRPSLDP--AAPALGPALHQRPPVHQGHPSPRC 173

Query: 224 PEAPALRAPPSGSLGPVLPVVTSASKLSPP 253
             +P+L +P +G  G   P+        PP
Sbjct: 174 AWSPSLCSPRAGDSGAPAPLTGLLPPPPPP 203


>gi|13540521 basic helix-loop-helix domain containing, class B, 3
           [Homo sapiens]
          Length = 482

 Score = 68.6 bits (166), Expect = 7e-12
 Identities = 43/122 (35%), Positives = 65/122 (53%), Gaps = 13/122 (10%)

Query: 56  IIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDA 115
           +IEK+RRDRIN  +++L+ L+P   +      LEKA +L++T+ HLK L     + +   
Sbjct: 51  LIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHLKALTALTEQQHQKI 110

Query: 116 HALAMDYRSL-------------GFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYA 162
            AL    RSL             GF+ C  EV +YLS  E     +P  V+L++HL+  A
Sbjct: 111 IALQNGERSLKSPIQSDLDAFHSGFQTCAKEVLQYLSRFESWTPREPRCVQLINHLHAVA 170

Query: 163 SQ 164
           +Q
Sbjct: 171 TQ 172


>gi|21361763 hairy and enhancer of split 6 isoform a [Homo sapiens]
          Length = 224

 Score = 65.1 bits (157), Expect = 7e-11
 Identities = 58/194 (29%), Positives = 89/194 (45%), Gaps = 14/194 (7%)

Query: 50  RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGG 109
           RK R+ ++EK+RR RIN SL ELR L+  A   +  AKLE AE+L++TV  ++ +     
Sbjct: 26  RKARKPLVEKKRRARINESLQELRLLLAGA---EVQAKLENAEVLELTVRRVQGVLRGRA 82

Query: 110 KGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAAS 169
           +      A A +  + G+ +C+ EV  ++S  + +DA+  +   L++HL      RE +S
Sbjct: 83  REREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDAT--VAAELLNHLLESMPLREGSS 140

Query: 170 ------GAHAGLGHIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAH 223
                  A AG    P  + +        P+  P    G      S  E   +  L  A 
Sbjct: 141 FQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPP---GPGDDLCSDLEEAPEAELSQAP 197

Query: 224 PEAPALRAPPSGSL 237
            E P L     GSL
Sbjct: 198 AEGPDLVPAALGSL 211


>gi|218751874 hairy and enhancer of split 6 isoform b [Homo sapiens]
          Length = 222

 Score = 64.7 bits (156), Expect = 1e-10
 Identities = 58/194 (29%), Positives = 88/194 (45%), Gaps = 16/194 (8%)

Query: 50  RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGG 109
           RK R+ ++EK+RR RIN SL ELR L+  A      AKLE AE+L++TV  ++ +     
Sbjct: 26  RKARKPLVEKKRRARINESLQELRLLLAGA-----EAKLENAEVLELTVRRVQGVLRGRA 80

Query: 110 KGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAAS 169
           +      A A +  + G+ +C+ EV  ++S  + +DA+  +   L++HL      RE +S
Sbjct: 81  REREQLQAEASERFAAGYIQCMHEVHTFVSTCQAIDAT--VAAELLNHLLESMPLREGSS 138

Query: 170 ------GAHAGLGHIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAH 223
                  A AG    P  + +        P+  P    G      S  E   +  L  A 
Sbjct: 139 FQDLLGDALAGPPRAPGRSGWPAGGAPGSPIPSPP---GPGDDLCSDLEEAPEAELSQAP 195

Query: 224 PEAPALRAPPSGSL 237
            E P L     GSL
Sbjct: 196 AEGPDLVPAALGSL 209


>gi|58219048 hairy and enhancer of split 5 [Homo sapiens]
          Length = 166

 Score = 62.4 bits (150), Expect = 5e-10
 Identities = 44/125 (35%), Positives = 75/125 (60%), Gaps = 13/125 (10%)

Query: 39  MSPTTSS-QILARKR----RRGIIEKRRRDRINNSLSELRRLVPSAFEK-QGSAKLEKAE 92
           M+P+T + ++L+ K     R+ ++EK RRDRIN+S+ +L+ L+   F + Q ++KLEKA+
Sbjct: 1   MAPSTVAVELLSPKEKNRLRKPVVEKMRRDRINSSIEQLKLLLEQEFARHQPNSKLEKAD 60

Query: 93  ILQMTVDHLKMLHTAGGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRV 152
           IL+M V +LK  H+          +L  DY S G+  CL E  ++L+    L A+   ++
Sbjct: 61  ILEMAVSYLK--HSKAFVAAAGPKSLHQDY-SEGYSWCLQEAVQFLT----LHAASDTQM 113

Query: 153 RLVSH 157
           +L+ H
Sbjct: 114 KLLYH 118


>gi|63055047 hairy and enhancer of split homolog 2 [Homo sapiens]
          Length = 173

 Score = 62.0 bits (149), Expect = 6e-10
 Identities = 58/194 (29%), Positives = 87/194 (44%), Gaps = 40/194 (20%)

Query: 50  RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGS--AKLEKAEILQMTVDHLKMLHTA 107
           RK  + ++EKRRR RIN SLS+L+ L+     ++ S  +KLEKA++L+MTV  L+ L  +
Sbjct: 14  RKSLKPLLEKRRRARINQSLSQLKGLILPLLGRENSNCSKLEKADVLEMTVRFLQELPAS 73

Query: 108 GGKGYFDAHALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREA 167
               +  A  L  D    G+  C+A +AR L     L+ +  +  RL+ HL      R A
Sbjct: 74  ---SWPTAAPLPCDSYREGYSACVARLARVLPACRVLEPA--VSARLLEHL-----WRRA 123

Query: 168 ASGAHAGLGHIPWGTVFGHHPHIAHPLLLPQNGHGNAGTTASPTEPHHQGRLGSAHPEAP 227
           AS    G                           G AG ++ P+ P       +  P + 
Sbjct: 124 ASATLDG---------------------------GRAGDSSGPSAP-APAPASAPEPASA 155

Query: 228 ALRAPPSGSLGPVL 241
            + +PPS   GP L
Sbjct: 156 PVPSPPSPPCGPGL 169


>gi|24586667 transcription factor-like protein 4 isoform gamma [Homo
           sapiens]
          Length = 298

 Score = 51.6 bits (122), Expect = 8e-07
 Identities = 40/145 (27%), Positives = 66/145 (45%), Gaps = 26/145 (17%)

Query: 4   AHPEYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQIL--------------- 48
           A  EY+ SD+ LD  + VE   +   G++ S   S+  T++S +                
Sbjct: 67  AKVEYAYSDNSLDPGLFVE---STRKGSVVSRANSIGSTSASSVPNTDDEDSDYHQEAYK 123

Query: 49  -----ARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQ---GSAKLEKAEILQMTVDH 100
                 R+R     E++RRD I     +L+ +VP+  ++    GS KL KA +LQ T+D+
Sbjct: 124 ESYKDRRRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDY 183

Query: 101 LKMLHTAGGKGYFDAHALAMDYRSL 125
           ++ LH    K   +   L  D  +L
Sbjct: 184 IQFLHKEKKKQEEEVSTLRKDVTAL 208


>gi|38201612 transcription factor-like protein 4 isoform beta [Homo
           sapiens]
          Length = 244

 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 39/142 (27%), Positives = 65/142 (45%), Gaps = 26/142 (18%)

Query: 7   EYSSSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQIL------------------ 48
           EY+ SD+ LD  + VE   +   G++ S   S+  T++S +                   
Sbjct: 16  EYAYSDNSLDPGLFVE---STRKGSVVSRANSIGSTSASSVPNTDDEDSDYHQEAYKESY 72

Query: 49  --ARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQ---GSAKLEKAEILQMTVDHLKM 103
              R+R     E++RRD I     +L+ +VP+  ++    GS KL KA +LQ T+D+++ 
Sbjct: 73  KDRRRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQF 132

Query: 104 LHTAGGKGYFDAHALAMDYRSL 125
           LH    K   +   L  D  +L
Sbjct: 133 LHKEKKKQEEEVSTLRKDVTAL 154


>gi|4503299 basic helix-loop-helix family, member e40 [Homo sapiens]
          Length = 412

 Score = 50.8 bits (120), Expect = 1e-06
 Identities = 37/125 (29%), Positives = 61/125 (48%), Gaps = 18/125 (14%)

Query: 56  IIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGGKGYFDA 115
           +IEK+RRDRIN  +++L+ L+P   +      LEKA +L++T+ H+K L     +     
Sbjct: 59  LIEKKRRDRINECIAQLKDLLPEHLKLTTLGHLEKAVVLELTLKHVKALTNLIDQQQQKI 118

Query: 116 HALAMDYRS----------------LGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLN 159
            AL    ++                 GF+ C  EV +YL+  E  +  D    +LV+HL+
Sbjct: 119 IALQSGLQAGELSGRNVETGQEMFCSGFQTCAREVLQYLAKHE--NTRDLKSSQLVTHLH 176

Query: 160 NYASQ 164
              S+
Sbjct: 177 RVVSE 181


>gi|71852580 aryl hydrocarbon receptor nuclear translocator-like
           isoform a [Homo sapiens]
          Length = 625

 Score = 46.2 bits (108), Expect = 4e-05
 Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 10/97 (10%)

Query: 11  SDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKRRRDRINNSLS 70
           S ++  E+++ +K+  D +G L             +I   +     IEKRRRD++N+ + 
Sbjct: 42  SSTDYQESMDTDKD--DPHGRLEYT------EHQGRIKNAREAHSQIEKRRRDKMNSFID 93

Query: 71  ELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTA 107
           EL  LVP+      S KL+K  +L+M V H+K L  A
Sbjct: 94  ELASLVPTC--NAMSRKLDKLTVLRMAVQHMKTLRGA 128


>gi|42716311 aryl hydrocarbon receptor nuclear translocator-like
           isoform a [Homo sapiens]
          Length = 625

 Score = 46.2 bits (108), Expect = 4e-05
 Identities = 31/97 (31%), Positives = 50/97 (51%), Gaps = 10/97 (10%)

Query: 11  SDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKRRRDRINNSLS 70
           S ++  E+++ +K+  D +G L             +I   +     IEKRRRD++N+ + 
Sbjct: 42  SSTDYQESMDTDKD--DPHGRLEYT------EHQGRIKNAREAHSQIEKRRRDKMNSFID 93

Query: 71  ELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTA 107
           EL  LVP+      S KL+K  +L+M V H+K L  A
Sbjct: 94  ELASLVPTC--NAMSRKLDKLTVLRMAVQHMKTLRGA 128


>gi|38201614 transcription factor-like protein 4 isoform alpha [Homo
           sapiens]
          Length = 214

 Score = 45.8 bits (107), Expect = 5e-05
 Identities = 26/79 (32%), Positives = 42/79 (53%), Gaps = 3/79 (3%)

Query: 50  RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQ---GSAKLEKAEILQMTVDHLKMLHT 106
           R+R     E++RRD I     +L+ +VP+  ++    GS KL KA +LQ T+D+++ LH 
Sbjct: 46  RRRAHTQAEQKRRDAIKRGYDDLQTIVPTCQQQDFSIGSQKLSKAIVLQKTIDYIQFLHK 105

Query: 107 AGGKGYFDAHALAMDYRSL 125
              K   +   L  D  +L
Sbjct: 106 EKKKQEEEVSTLRKDVTAL 124


>gi|71852582 aryl hydrocarbon receptor nuclear translocator-like
           isoform b [Homo sapiens]
          Length = 582

 Score = 45.1 bits (105), Expect = 8e-05
 Identities = 24/51 (47%), Positives = 33/51 (64%), Gaps = 2/51 (3%)

Query: 57  IEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTA 107
           IEKRRRD++N+ + EL  LVP+      S KL+K  +L+M V H+K L  A
Sbjct: 37  IEKRRRDKMNSFIDELASLVPTC--NAMSRKLDKLTVLRMAVQHMKTLRGA 85


>gi|66912172 hairy and enhancer of split 3 [Homo sapiens]
          Length = 186

 Score = 45.1 bits (105), Expect = 8e-05
 Identities = 48/162 (29%), Positives = 76/162 (46%), Gaps = 13/162 (8%)

Query: 57  IEKRRRDRINNSLSELRRLVPSAFEKQ-GSAKLEKAEILQMTVDHLKMLHTAGGKGYFDA 115
           +EK+RR RIN SL +L+ L+   +  Q    KLEKA+IL+++V +++ L  +  +G +  
Sbjct: 1   MEKKRRARINVSLEQLKSLLEKHYSHQIRKRKLEKADILELSVKYMRSLQNS-LQGLWPV 59

Query: 116 HALAMDYRSLGFRECLAEVARYLSIIEGLDASDPLRVRLVSHLNNYASQREAASGAHAGL 175
              A   +  GFR CL  V++ L    G +    LR  LV      ++   A  G  A  
Sbjct: 60  PRGA--EQPSGFRSCLPGVSQLLR--RGDEVGSGLRCPLVPESAAGSTMDSAGLGQEAPA 115

Query: 176 GHIP-WGTVFGHHPHIAHP------LLLPQNGHGNAGTTASP 210
              P    V+   P    P      LLLP++  G++ +   P
Sbjct: 116 LFRPCTPAVWAPAPAAGGPRSPPPLLLLPESLPGSSASVPPP 157


>gi|31745180 aryl hydrocarbon receptor nuclear translocator-like 2
           [Homo sapiens]
          Length = 636

 Score = 41.6 bits (96), Expect = 9e-04
 Identities = 20/47 (42%), Positives = 30/47 (63%), Gaps = 2/47 (4%)

Query: 58  EKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKML 104
           EKRRRD++NN + EL  ++P       + KL+K  +L+M V HL+ L
Sbjct: 116 EKRRRDKMNNLIEELSAMIPQC--NPMARKLDKLTVLRMAVQHLRSL 160


>gi|52630419 sterol regulatory element binding transcription factor
           1 isoform a [Homo sapiens]
          Length = 1177

 Score = 40.0 bits (92), Expect = 0.003
 Identities = 23/76 (30%), Positives = 39/76 (51%), Gaps = 5/76 (6%)

Query: 35  ALGSMSPTTSSQILARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEIL 94
           A GS +P ++     ++     IEKR R  IN+ + EL+ LV         AKL K+ +L
Sbjct: 339 AAGSKAPASAQSRGEKRTAHNAIEKRYRSSINDKIIELKDLVVGT-----EAKLNKSAVL 393

Query: 95  QMTVDHLKMLHTAGGK 110
           +  +D+++ L  +  K
Sbjct: 394 RKAIDYIRFLQHSNQK 409


>gi|22547195 sterol regulatory element binding transcription factor
           1 isoform b [Homo sapiens]
          Length = 1147

 Score = 40.0 bits (92), Expect = 0.003
 Identities = 23/76 (30%), Positives = 39/76 (51%), Gaps = 5/76 (6%)

Query: 35  ALGSMSPTTSSQILARKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEIL 94
           A GS +P ++     ++     IEKR R  IN+ + EL+ LV         AKL K+ +L
Sbjct: 309 AAGSKAPASAQSRGEKRTAHNAIEKRYRSSINDKIIELKDLVVGT-----EAKLNKSAVL 363

Query: 95  QMTVDHLKMLHTAGGK 110
           +  +D+++ L  +  K
Sbjct: 364 RKAIDYIRFLQHSNQK 379


>gi|66529407 tensin [Homo sapiens]
          Length = 1735

 Score = 39.3 bits (90), Expect = 0.004
 Identities = 43/133 (32%), Positives = 51/133 (38%), Gaps = 15/133 (11%)

Query: 169  SGAHAGLGHIPWGTVFGHHPHIAHPLLLPQNGHGNA-GTTASPTEPHHQGRLGSAHPEAP 227
            SG H  +   P     G HP  AH   L    H NA  +  SP+   H G  GS  P +P
Sbjct: 1257 SGLHNKVATTPGSPSLGRHPG-AHQGNLASGLHSNAIASPGSPSLGRHLGGSGSVVPGSP 1315

Query: 228  AL-RAPPSGSLG------PVLPVVTSASKLSPPLLSSVASLSAFPFSFGSFHLLSPNALS 280
             L R    G         P L   +SAS    P      S  +FP S   +  LS  A S
Sbjct: 1316 CLDRHVAYGGYSTPEDRRPTLSRQSSASGYQAP------STPSFPVSPAYYPGLSSPATS 1369

Query: 281  PSAPTQAANLGKP 293
            PS  + A   G P
Sbjct: 1370 PSPDSAAFRQGSP 1382


>gi|46877105 upstream stimulatory factor 2 isoform 2 [Homo sapiens]
          Length = 279

 Score = 37.7 bits (86), Expect = 0.013
 Identities = 20/75 (26%), Positives = 36/75 (48%), Gaps = 3/75 (4%)

Query: 50  RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGG 109
           R+ +   +E+RRRD+INN + +L +++P            K  IL    D+++ L     
Sbjct: 169 RRAQHNEVERRRRDKINNWIVQLSKIIPDCNADNSKTGASKGGILSKACDYIRELRQTNQ 228

Query: 110 K---GYFDAHALAMD 121
           +    + +A  L MD
Sbjct: 229 RMQETFKEAERLQMD 243


>gi|4507847 upstream stimulatory factor 2 isoform 1 [Homo sapiens]
          Length = 346

 Score = 37.7 bits (86), Expect = 0.013
 Identities = 20/75 (26%), Positives = 36/75 (48%), Gaps = 3/75 (4%)

Query: 50  RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGG 109
           R+ +   +E+RRRD+INN + +L +++P            K  IL    D+++ L     
Sbjct: 236 RRAQHNEVERRRRDKINNWIVQLSKIIPDCNADNSKTGASKGGILSKACDYIRELRQTNQ 295

Query: 110 K---GYFDAHALAMD 121
           +    + +A  L MD
Sbjct: 296 RMQETFKEAERLQMD 310


>gi|27477113 sterol regulatory element-binding transcription factor
           2 [Homo sapiens]
          Length = 1141

 Score = 37.4 bits (85), Expect = 0.017
 Identities = 21/61 (34%), Positives = 32/61 (52%), Gaps = 5/61 (8%)

Query: 50  RKRRRGIIEKRRRDRINNSLSELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKMLHTAGG 109
           R+    IIEKR R  IN+ + EL+ LV         AK+ K+ +L+  +D++K L     
Sbjct: 331 RRTTHNIIEKRYRSSINDKIIELKDLVMGT-----DAKMHKSGVLRKAIDYIKYLQQVNH 385

Query: 110 K 110
           K
Sbjct: 386 K 386


>gi|8659574 transcription factor E3 [Homo sapiens]
          Length = 575

 Score = 37.0 bits (84), Expect = 0.022
 Identities = 24/95 (25%), Positives = 42/95 (44%), Gaps = 2/95 (2%)

Query: 10  SSDSELDETIEVEKESADENGNLSSALGSMSPTTSSQILARKRRRGIIEKRRRDRINNSL 69
           SS       I V      E  N+   +         +   +K    +IE+RRR  IN+ +
Sbjct: 307 SSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRI 366

Query: 70  SELRRLVPSAFEKQGSAKLEKAEILQMTVDHLKML 104
            EL  L+P + + +   +  K  IL+ +VD+++ L
Sbjct: 367 KELGTLIPKSSDPE--MRWNKGTILKASVDYIRKL 399


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.314    0.130    0.381 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 12,185,410
Number of Sequences: 37866
Number of extensions: 583212
Number of successful extensions: 3031
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 71
Number of HSP's successfully gapped in prelim test: 163
Number of HSP's that attempted gapping in prelim test: 2776
Number of HSP's gapped (non-prelim): 370
length of query: 304
length of database: 18,247,518
effective HSP length: 102
effective length of query: 202
effective length of database: 14,385,186
effective search space: 2905807572
effective search space used: 2905807572
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (22.0 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.