Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Search of human proteins with 105990514
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|105990514 filamin B, beta (actin binding protein 278) [Homo
sapiens]
(2602 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|105990514 filamin B, beta (actin binding protein 278) [Homo s... 5289 0.0
gi|116063573 filamin A, alpha isoform 1 [Homo sapiens] 3802 0.0
gi|160420317 filamin A, alpha isoform 2 [Homo sapiens] 3795 0.0
gi|116805322 gamma filamin isoform a [Homo sapiens] 3205 0.0
gi|188595687 gamma filamin isoform b [Homo sapiens] 3190 0.0
gi|239755812 PREDICTED: similar to spectrin, beta, non-erythrocy... 218 8e-56
gi|4557241 actinin, alpha 3 [Homo sapiens] 159 3e-38
gi|4501893 actinin, alpha 2 [Homo sapiens] 157 2e-37
gi|12025678 actinin, alpha 4 [Homo sapiens] 156 2e-37
gi|194097352 actinin, alpha 1 isoform c [Homo sapiens] 152 3e-36
gi|194097350 actinin, alpha 1 isoform a [Homo sapiens] 152 3e-36
gi|4501891 actinin, alpha 1 isoform b [Homo sapiens] 152 3e-36
gi|33188445 microfilament and actin filament cross-linker protei... 144 1e-33
gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo ... 140 2e-32
gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo ... 139 3e-32
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 139 3e-32
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 139 3e-32
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 139 3e-32
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 139 3e-32
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 139 3e-32
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 139 3e-32
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 139 3e-32
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 139 3e-32
gi|221316624 dystonin isoform 4 [Homo sapiens] 139 4e-32
gi|221316622 dystonin isoform 3 [Homo sapiens] 139 4e-32
gi|221316618 dystonin isoform 2 [Homo sapiens] 139 4e-32
gi|34577047 dystonin isoform 1 [Homo sapiens] 139 4e-32
gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens] 138 6e-32
gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1 [... 138 6e-32
gi|67782321 spectrin beta isoform a [Homo sapiens] 137 1e-31
>gi|105990514 filamin B, beta (actin binding protein 278) [Homo
sapiens]
Length = 2602
Score = 5289 bits (13720), Expect = 0.0
Identities = 2602/2602 (100%), Positives = 2602/2602 (100%)
Query: 1 MPVTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQK 60
MPVTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQK
Sbjct: 1 MPVTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQK 60
Query: 61 RMYRKYHQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILH 120
RMYRKYHQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILH
Sbjct: 61 RMYRKYHQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILH 120
Query: 121 YSISMPVWEDEGDDDAKKQTPKQRLLGWIQNKIPYLPITNFNQNWQDGKALGALVDSCAP 180
YSISMPVWEDEGDDDAKKQTPKQRLLGWIQNKIPYLPITNFNQNWQDGKALGALVDSCAP
Sbjct: 121 YSISMPVWEDEGDDDAKKQTPKQRLLGWIQNKIPYLPITNFNQNWQDGKALGALVDSCAP 180
Query: 181 GLCPDWESWDPQKPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLSQFPKA 240
GLCPDWESWDPQKPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLSQFPKA
Sbjct: 181 GLCPDWESWDPQKPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLSQFPKA 240
Query: 241 KLKPGAPLKPKLNPKKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGNK 300
KLKPGAPLKPKLNPKKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGNK
Sbjct: 241 KLKPGAPLKPKLNPKKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGNK 300
Query: 301 EEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVSVDKAQGDASKVTAK 360
EEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVSVDKAQGDASKVTAK
Sbjct: 301 EEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVSVDKAQGDASKVTAK 360
Query: 361 GPGLEAVGNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDKGNQVYRCVYKP 420
GPGLEAVGNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDKGNQVYRCVYKP
Sbjct: 361 GPGLEAVGNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDKGNQVYRCVYKP 420
Query: 421 MQPGPHVVKIFFAGDTIPKSPFVVQVGEACNPNACRASGRGLQPKGVRIRETTDFKVDTK 480
MQPGPHVVKIFFAGDTIPKSPFVVQVGEACNPNACRASGRGLQPKGVRIRETTDFKVDTK
Sbjct: 421 MQPGPHVVKIFFAGDTIPKSPFVVQVGEACNPNACRASGRGLQPKGVRIRETTDFKVDTK 480
Query: 481 AAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITWGGHHIPKSPFE 540
AAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITWGGHHIPKSPFE
Sbjct: 481 AAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITWGGHHIPKSPFE 540
Query: 541 VQVGPEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYNDQN 600
VQVGPEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYNDQN
Sbjct: 541 VQVGPEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYNDQN 600
Query: 601 DGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGYNPDLVRAYGPGLEKSGC 660
DGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGYNPDLVRAYGPGLEKSGC
Sbjct: 601 DGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGYNPDLVRAYGPGLEKSGC 660
Query: 661 IVNNLAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGTYACSYTPVKAIKHTIAV 720
IVNNLAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGTYACSYTPVKAIKHTIAV
Sbjct: 661 IVNNLAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGTYACSYTPVKAIKHTIAV 720
Query: 721 VWGGVNIPHSPYRVNIGQGSHPQKVKVFGPGVERSGLKANEPTHFTVDCTEAGEGDVSVG 780
VWGGVNIPHSPYRVNIGQGSHPQKVKVFGPGVERSGLKANEPTHFTVDCTEAGEGDVSVG
Sbjct: 721 VWGGVNIPHSPYRVNIGQGSHPQKVKVFGPGVERSGLKANEPTHFTVDCTEAGEGDVSVG 780
Query: 781 IKCDARVLSEDEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPASPFRVKVD 840
IKCDARVLSEDEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPASPFRVKVD
Sbjct: 781 IKCDARVLSEDEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPASPFRVKVD 840
Query: 841 PSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFNSPLPGDAVKDLDIID 900
PSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFNSPLPGDAVKDLDIID
Sbjct: 841 PSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFNSPLPGDAVKDLDIID 900
Query: 901 NYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTVGVAAPLDLSKIKLNGLENRVEVGK 960
NYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTVGVAAPLDLSKIKLNGLENRVEVGK
Sbjct: 901 NYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTVGVAAPLDLSKIKLNGLENRVEVGK 960
Query: 961 DQEFTVDTRGAGGQGKLDVTILSPSRKVVPCLVTPVTGRENSTAKFIPREEGLYAVDVTY 1020
DQEFTVDTRGAGGQGKLDVTILSPSRKVVPCLVTPVTGRENSTAKFIPREEGLYAVDVTY
Sbjct: 961 DQEFTVDTRGAGGQGKLDVTILSPSRKVVPCLVTPVTGRENSTAKFIPREEGLYAVDVTY 1020
Query: 1021 DGHPVPGSPYTVEASLPPDPSKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTVEGP 1080
DGHPVPGSPYTVEASLPPDPSKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTVEGP
Sbjct: 1021 DGHPVPGSPYTVEASLPPDPSKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTVEGP 1080
Query: 1081 CEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVASG 1140
CEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVASG
Sbjct: 1081 CEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVASG 1140
Query: 1141 PGLEHGKVGEAGLLSVDCSEAGPGALGLEAVSDSGTKAEVSIQNNKDGTYAVTYVPLTAG 1200
PGLEHGKVGEAGLLSVDCSEAGPGALGLEAVSDSGTKAEVSIQNNKDGTYAVTYVPLTAG
Sbjct: 1141 PGLEHGKVGEAGLLSVDCSEAGPGALGLEAVSDSGTKAEVSIQNNKDGTYAVTYVPLTAG 1200
Query: 1201 MYTLTMKYGGELVPHFPARVKVEPAVDTSRIKVFGPGIEGKDVFREATTDFTVDSRPLTQ 1260
MYTLTMKYGGELVPHFPARVKVEPAVDTSRIKVFGPGIEGKDVFREATTDFTVDSRPLTQ
Sbjct: 1201 MYTLTMKYGGELVPHFPARVKVEPAVDTSRIKVFGPGIEGKDVFREATTDFTVDSRPLTQ 1260
Query: 1261 VGGDHIKAHIANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPIPNSPFKV 1320
VGGDHIKAHIANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPIPNSPFKV
Sbjct: 1261 VGGDHIKAHIANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPIPNSPFKV 1320
Query: 1321 AVTEGCQPSRVQAQGPGLKEAFTNKPNVFTVVTRGAGIGGLGITVEGPSESKINCRDNKD 1380
AVTEGCQPSRVQAQGPGLKEAFTNKPNVFTVVTRGAGIGGLGITVEGPSESKINCRDNKD
Sbjct: 1321 AVTEGCQPSRVQAQGPGLKEAFTNKPNVFTVVTRGAGIGGLGITVEGPSESKINCRDNKD 1380
Query: 1381 GSCSAEYIPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVDPSKVKIAGPGLGSGVRARVL 1440
GSCSAEYIPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVDPSKVKIAGPGLGSGVRARVL
Sbjct: 1381 GSCSAEYIPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVDPSKVKIAGPGLGSGVRARVL 1440
Query: 1441 QSFTVDSSKAGLAPLEVRVLGPRGLVEPVNVVDNGDGTHTVTYTPSQEGPYMVSVKYADE 1500
QSFTVDSSKAGLAPLEVRVLGPRGLVEPVNVVDNGDGTHTVTYTPSQEGPYMVSVKYADE
Sbjct: 1441 QSFTVDSSKAGLAPLEVRVLGPRGLVEPVNVVDNGDGTHTVTYTPSQEGPYMVSVKYADE 1500
Query: 1501 EIPRSPFKVKVLPTYDASKVTASGPGLSSYGVPASLPVDFAIDARDAGEGLLAVQITDQE 1560
EIPRSPFKVKVLPTYDASKVTASGPGLSSYGVPASLPVDFAIDARDAGEGLLAVQITDQE
Sbjct: 1501 EIPRSPFKVKVLPTYDASKVTASGPGLSSYGVPASLPVDFAIDARDAGEGLLAVQITDQE 1560
Query: 1561 GKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGVTYGGDDIPLSPYRIRATQTGDASKCLAT 1620
GKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGVTYGGDDIPLSPYRIRATQTGDASKCLAT
Sbjct: 1561 GKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGVTYGGDDIPLSPYRIRATQTGDASKCLAT 1620
Query: 1621 GPGIASTVKTGEEVGFVVDAKTAGKGKVTCTVLTPDGTEAEADVIENEDGTYDIFYTAAK 1680
GPGIASTVKTGEEVGFVVDAKTAGKGKVTCTVLTPDGTEAEADVIENEDGTYDIFYTAAK
Sbjct: 1621 GPGIASTVKTGEEVGFVVDAKTAGKGKVTCTVLTPDGTEAEADVIENEDGTYDIFYTAAK 1680
Query: 1681 PGTYVIYVRFGGVDIPNSPFTVMATDGEVTAVEEAPVNACPPGFRPWVTEEAYVPVSDMN 1740
PGTYVIYVRFGGVDIPNSPFTVMATDGEVTAVEEAPVNACPPGFRPWVTEEAYVPVSDMN
Sbjct: 1681 PGTYVIYVRFGGVDIPNSPFTVMATDGEVTAVEEAPVNACPPGFRPWVTEEAYVPVSDMN 1740
Query: 1741 GLGFKPFDLVIPFAVRKGEITGEVHMPSGKTATPEIVDNKDGTVTVRYAPTEVGLHEMHI 1800
GLGFKPFDLVIPFAVRKGEITGEVHMPSGKTATPEIVDNKDGTVTVRYAPTEVGLHEMHI
Sbjct: 1741 GLGFKPFDLVIPFAVRKGEITGEVHMPSGKTATPEIVDNKDGTVTVRYAPTEVGLHEMHI 1800
Query: 1801 KYMGSHIPESPLQFYVNYPNSGSVSAYGPGLVYGVANKTATFTIVTEDAGEGGLDLAIEG 1860
KYMGSHIPESPLQFYVNYPNSGSVSAYGPGLVYGVANKTATFTIVTEDAGEGGLDLAIEG
Sbjct: 1801 KYMGSHIPESPLQFYVNYPNSGSVSAYGPGLVYGVANKTATFTIVTEDAGEGGLDLAIEG 1860
Query: 1861 PSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGSPFTAKITDDSRRCSQVKL 1920
PSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGSPFTAKITDDSRRCSQVKL
Sbjct: 1861 PSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGSPFTAKITDDSRRCSQVKL 1920
Query: 1921 GSAADFLLDISETDLSSLTASIKAPSGRDEPCLLKRLPNNHIGISFIPREVGEHLVSIKK 1980
GSAADFLLDISETDLSSLTASIKAPSGRDEPCLLKRLPNNHIGISFIPREVGEHLVSIKK
Sbjct: 1921 GSAADFLLDISETDLSSLTASIKAPSGRDEPCLLKRLPNNHIGISFIPREVGEHLVSIKK 1980
Query: 1981 NGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFEMSDFIVDTRDAGYGGISLAVE 2040
NGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFEMSDFIVDTRDAGYGGISLAVE
Sbjct: 1981 NGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFEMSDFIVDTRDAGYGGISLAVE 2040
Query: 2041 GPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVPGSPFTVKISGEGRVKESIT 2100
GPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVPGSPFTVKISGEGRVKESIT
Sbjct: 2041 GPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVPGSPFTVKISGEGRVKESIT 2100
Query: 2101 RTSRAPSVATVGSICDLNLKIPEINSSDMSAHVTSPSGRVTEAEIVPMGKNSHCVRFVPQ 2160
RTSRAPSVATVGSICDLNLKIPEINSSDMSAHVTSPSGRVTEAEIVPMGKNSHCVRFVPQ
Sbjct: 2101 RTSRAPSVATVGSICDLNLKIPEINSSDMSAHVTSPSGRVTEAEIVPMGKNSHCVRFVPQ 2160
Query: 2161 EMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGPGLERGEAGVPAEFSIWTRE 2220
EMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGPGLERGEAGVPAEFSIWTRE
Sbjct: 2161 EMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGPGLERGEAGVPAEFSIWTRE 2220
Query: 2221 AGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYEVSIKFNDEHIPESPYLVPV 2280
AGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYEVSIKFNDEHIPESPYLVPV
Sbjct: 2221 AGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYEVSIKFNDEHIPESPYLVPV 2280
Query: 2281 IAPSDDARRLTVMSLQESGLKVNQPASFAIRLNGAKGKIDAKVHSPSGAVEECHVSELEP 2340
IAPSDDARRLTVMSLQESGLKVNQPASFAIRLNGAKGKIDAKVHSPSGAVEECHVSELEP
Sbjct: 2281 IAPSDDARRLTVMSLQESGLKVNQPASFAIRLNGAKGKIDAKVHSPSGAVEECHVSELEP 2340
Query: 2341 DKYAVRFIPHENGVHTIDVKFNGSHVVGSPFKVRVGEPGQAGNPALVSAYGTGLEGGTTG 2400
DKYAVRFIPHENGVHTIDVKFNGSHVVGSPFKVRVGEPGQAGNPALVSAYGTGLEGGTTG
Sbjct: 2341 DKYAVRFIPHENGVHTIDVKFNGSHVVGSPFKVRVGEPGQAGNPALVSAYGTGLEGGTTG 2400
Query: 2401 IQSEFFINTTRAGPGTLSVTIEGPSKVKMDCQETPEGYKVMYTPMAPGNYLISVKYGGPN 2460
IQSEFFINTTRAGPGTLSVTIEGPSKVKMDCQETPEGYKVMYTPMAPGNYLISVKYGGPN
Sbjct: 2401 IQSEFFINTTRAGPGTLSVTIEGPSKVKMDCQETPEGYKVMYTPMAPGNYLISVKYGGPN 2460
Query: 2461 HIVGSPFKAKVTGQRLVSPGSANETSSILVESVTRSSTETCYSAIPKASSDASKVTSKGA 2520
HIVGSPFKAKVTGQRLVSPGSANETSSILVESVTRSSTETCYSAIPKASSDASKVTSKGA
Sbjct: 2461 HIVGSPFKAKVTGQRLVSPGSANETSSILVESVTRSSTETCYSAIPKASSDASKVTSKGA 2520
Query: 2521 GLSKAFVGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSMKHVGNQQYNVTYVVKERGD 2580
GLSKAFVGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSMKHVGNQQYNVTYVVKERGD
Sbjct: 2521 GLSKAFVGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSMKHVGNQQYNVTYVVKERGD 2580
Query: 2581 YVLAVKWGEEHIPGSPFHVTVP 2602
YVLAVKWGEEHIPGSPFHVTVP
Sbjct: 2581 YVLAVKWGEEHIPGSPFHVTVP 2602
>gi|116063573 filamin A, alpha isoform 1 [Homo sapiens]
Length = 2639
Score = 3802 bits (9860), Expect = 0.0
Identities = 1827/2613 (69%), Positives = 2164/2613 (82%), Gaps = 12/2613 (0%)
Query: 1 MPVTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQK 60
MP TEKDLAEDAPWKKIQQNTFTRWCNEHLKCV+KRI NLQTDLSDGLRLIALLEVLSQK
Sbjct: 28 MPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLIALLEVLSQK 87
Query: 61 RMYRKYHQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILH 120
+M+RK++QRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGL+WTLILH
Sbjct: 88 KMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILH 147
Query: 121 YSISMPVWEDEGDDDAKKQTPKQRLLGWIQNKIPYLPITNFNQNWQDGKALGALVDSCAP 180
YSISMP+W++E D++AKKQTPKQRLLGWIQNK+P LPITNF+++WQ G+ALGALVDSCAP
Sbjct: 148 YSISMPMWDEEEDEEAKKQTPKQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAP 207
Query: 181 GLCPDWESWDPQKPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLSQFPKA 240
GLCPDW+SWD KPV NAREAMQQADDWLG+PQVITPEEI+ P+VDEHSVMTYLSQFPKA
Sbjct: 208 GLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVMTYLSQFPKA 267
Query: 241 KLKPGAPLKPKLNPKKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGNK 300
KLKPGAPL+PKLNPKKARAYG GIEPTGNMVK+ A+FTV+T SAGQG+V+V+VEDP G++
Sbjct: 268 KLKPGAPLRPKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQ 327
Query: 301 EEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVSVDKAQGDASKVTAK 360
EEA+VT ++DKN+T+SV Y+P+VTG HKVTVLFAGQHI+KSPFEV VDK+QGDASKVTA+
Sbjct: 328 EEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQ 387
Query: 361 GPGLEAVGNIANKPTYFDIYTAGAGVGDIGVEVEDPQG-KNTVELLVEDKGNQVYRCVYK 419
GPGLE GNIANK TYF+I+TAGAG G++ V ++DP G K TVE +E +G+ YRC Y+
Sbjct: 388 GPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPMGQKGTVEPQLEARGDSTYRCSYQ 447
Query: 420 PMQPGPHVVKIFFAGDTIPKSPFVVQVGEACNPNACRASGRGLQPKGVRIRETTDFKVDT 479
P G H V + FAG IP+SP+ V VG+ACNP+ACRA GRGLQPKGVR++ET DFKV T
Sbjct: 448 PTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNPSACRAVGRGLQPKGVRVKETADFKVYT 507
Query: 480 KAAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITWGGHHIPKSPF 539
K AGSGEL VT+KGPKG EE VKQKD DGVY FEYYP PG Y + ITWGG +I +SPF
Sbjct: 508 KGAGSGELKVTVKGPKG-EERVKQKDLGDGVYGFEYYPMVPGTYIVTITWGGQNIGRSPF 566
Query: 540 EVQVGPEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYNDQ 599
EV+VG E G QKVRAWGPGL GG+VG+SADFVVE+IG +VG+LGF++EGPSQAKIE +D+
Sbjct: 567 EVKVGTECGNQKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQAKIECDDK 626
Query: 600 NDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGYNPDLVRAYGPGLEKSG 659
DGSCDV+YWP+E GEYAVH++C+ EDI+ SP+MA I A ++PD V+A GPGLEK+G
Sbjct: 627 GDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIRDAPQDFHPDRVKARGPGLEKTG 686
Query: 660 CIVNNLAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGTYACSYTPVKAIKHTIA 719
VN AEFTVD K GKAPL++ QD EG ++ +K+ +GTY+CSY P K +KHT
Sbjct: 687 VAVNKPAEFTVDAKHGGKAPLRVQVQDNEGCPVEALVKDNGNGTYSCSYVPRKPVKHTAM 746
Query: 720 VVWGGVNIPHSPYRVNIGQGSHPQKVKVFGPGVERSGLKANEPTHFTVDCTEAGEGDVSV 779
V WGGV+IP+SP+RVN+G GSHP KVKV+GPGV ++GLKA+EPT+FTVDC EAG+GDVS+
Sbjct: 747 VSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCAEAGQGDVSI 806
Query: 780 GIKCDARVLSEDEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPASPFRVKV 839
GIKC V+ E D+DFDII N NDTFTVKY P AG YTI VLFA Q P SP RVKV
Sbjct: 807 GIKCAPGVVGPAEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKV 866
Query: 840 DPSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFNSPLPGDAVKDLDII 899
+PSHDASKVKAEGPGLS+ GVE GKPTHFTV K AGK L+VQF+ GDAV+D+DII
Sbjct: 867 EPSHDASKVKAEGPGLSRTGVELGKPTHFTVNAKAAGKGKLDVQFSGLTKGDAVRDVDII 926
Query: 900 DNYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTVGVAAPLDLSKIKLNGLENRVEVG 959
D++D ++TVKYTP QQG + V VTYGGDPIPKSPF+V V+ LDLSKIK++GL +V+VG
Sbjct: 927 DHHDNTYTVKYTPVQQGPVGVNVTYGGDPIPKSPFSVAVSPSLDLSKIKVSGLGEKVDVG 986
Query: 960 KDQEFTVDTRGAGGQGKLDVTILSPSRKVVPCLVTPVTGRENSTAKFIPREEGLYAVDVT 1019
KDQEFTV ++GAGGQGK+ I+ PS VPC V P G +NS +F+PREEG Y V+VT
Sbjct: 987 KDQEFTVKSKGAGGQGKVASKIVGPSGAAVPCKVEPGLGADNSVVRFLPREEGPYEVEVT 1046
Query: 1020 YDGHPVPGSPYTVEASLPPDPSKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTVEG 1079
YDG PVPGSP+ +EA P PSKVKA GPGL+GG G PA FTIDTKGAGTGGLGLTVEG
Sbjct: 1047 YDGVPVPGSPFPLEAVAPTKPSKVKAFGPGLQGGSAGSPARFTIDTKGAGTGGLGLTVEG 1106
Query: 1080 PCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVAS 1139
PCEA++EC DNGDGTCSVSY+PT+PG+Y +NILF + HIPGSPFKA + FD SKV S
Sbjct: 1107 PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFDASKVKCS 1166
Query: 1140 GPGLEHGKVGEAGLLSVDCSEAGPGALGLEAVSDSGTKAEVSIQNNKDGTYAVTYVPLTA 1199
GPGLE GE G VDCS AG L +E S++G AEV IQ++ DGT+ +TY+PL
Sbjct: 1167 GPGLERATAGEVGQFQVDCSSAGSAELTIEICSEAGLPAEVYIQDHGDGTHTITYIPLCP 1226
Query: 1200 GMYTLTMKYGGELVPHFPARVKVEPAVDTSRIKVFGPGIEGKDVFREATTDFTVDSRPLT 1259
G YT+T+KYGG+ VP+FP++++VEPAVDTS ++ +GPGIEG+ VFREATT+F+VD+R LT
Sbjct: 1227 GAYTVTIKYGGQPVPNFPSKLQVEPAVDTSGVQCYGPGIEGQGVFREATTEFSVDARALT 1286
Query: 1260 QVGGDHIKAHIANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPIPNSPFK 1319
Q GG H+KA +ANPSG TE +V D DG Y+VEYTP+E+GLH V+VTYD P+P+SPF+
Sbjct: 1287 QTGGPHVKARVANPSGNLTETYVQDRGDGMYKVEYTPYEEGLHSVDVTYDGSPVPSSPFQ 1346
Query: 1320 VAVTEGCQPSRVQAQGPGLKEAFTNKPNVFTVVTRGAGIGGLGITVEGPSESKINCRDNK 1379
V VTEGC PSRV+ GPG++ TNKPN FTV TRGAG GGLG+ VEGPSE+K++C DNK
Sbjct: 1347 VPVTEGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPSEAKMSCMDNK 1406
Query: 1380 DGSCSAEYIPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVDPSKVKIAGPGLGSG-VRAR 1438
DGSCS EYIP+ G Y +N+TYGG +PGSPF+VPV DV D SKVK +GPGL G VRA
Sbjct: 1407 DGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTDASKVKCSGPGLSPGMVRAN 1466
Query: 1439 VLQSFTVDSSKAGLAPLEVRVLGPRGLVEPVNVVDNGDGTHTVTYTPSQEGPYMVSVKYA 1498
+ QSF VD+SKAG+APL+V+V GP+GLVEPV+VVDN DGT TV Y PS+EGPY +SV Y
Sbjct: 1467 LPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPYSISVLYG 1526
Query: 1499 DEEIPRSPFKVKVLPTYDASKVTASGPGLSSYGVPASLPVDFAIDARDAGEGLLAVQITD 1558
DEE+PRSPFKVKVLPT+DASKV ASGPGL++ GVPASLPV+F IDA+DAGEGLLAVQITD
Sbjct: 1527 DEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEGLLAVQITD 1586
Query: 1559 QEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGVTYGGDDIPLSPYRIRATQTGDASKCL 1618
EGKPK+ + DN DGTY V Y+PD TGRY I + YGGD+IP SPYR+RA TGDASKC
Sbjct: 1587 PEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVPTGDASKCT 1646
Query: 1619 ATGPGIASTVKTGEEVGFVVDAKTAGKGKVTCTVLTPDGTEAEADVIENEDGTYDIFYTA 1678
TG GI T++ GEE VD K AGKGKVTCTV TPDG+E + DV+ENEDGT+DIFYTA
Sbjct: 1647 VTGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDGTFDIFYTA 1706
Query: 1679 AKPGTYVIYVRFGGVDIPNSPFTVMATDGEVTAVEE-------AP-VNACPPGFRPWVTE 1730
+PG YVI VRFGG +PNSPF V A G+ +V+ AP G + W E
Sbjct: 1707 PQPGKYVICVRFGGEHVPNSPFQVTALAGDQPSVQPPLRSQQLAPQYTYAQGGQQTWAPE 1766
Query: 1731 EAYVPVSDMNGLGFKPFDLVIPFAVRKGEITGEVHMPSGKTATPEIVDNKDGTVTVRYAP 1790
V V+ ++ +PFDLVIPF ++KGEITGEV MPSGK A P I DNKDGTVTVRYAP
Sbjct: 1767 RPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPTITDNKDGTVTVRYAP 1826
Query: 1791 TEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVSAYGPGLVYGVANKTATFTIVTEDAG 1850
+E GLHEM I+Y HIP SPLQFYV+Y N G V+AYGPGL +GV NK ATFT+ T+DAG
Sbjct: 1827 SEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLTHGVVNKPATFTVNTKDAG 1886
Query: 1851 EGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGSPFTAKIT- 1909
EGGL LAIEGPSKAEISC DN+DGTC+V+YLP LPGDYSILVKYN++H+PGSPFTA++T
Sbjct: 1887 EGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHVPGSPFTARVTG 1946
Query: 1910 DDSRRCSQVKLGSAADFLLDISETDLSSLTASIKAPSGRDEPCLLKRLPNNHIGISFIPR 1969
DDS R S +K+GSAAD ++ISETDLS LTA++ PSGR+EPCLLKRL N H+GISF+P+
Sbjct: 1947 DDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGHVGISFVPK 2006
Query: 1970 EVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFEMSDFIVDTRD 2029
E GEHLV +KKNG HVA+SP+ +++ QSEIGDA R +V G+GL EG TFE ++FI+DTRD
Sbjct: 2007 ETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGQGLHEGHTFEPAEFIIDTRD 2066
Query: 2030 AGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVPGSPFTVKI 2089
AGYGG+SL++EGPSKVDI TEDLEDGTC+V+Y PT PG YI++ KFAD+HVPGSPF+VK+
Sbjct: 2067 AGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVPGSPFSVKV 2126
Query: 2090 SGEGRVKESITRTSRAPSVATVGSICDLNLKIPEINSSDMSAHVTSPSGRVTEAEIVPMG 2149
+GEGRVKESITR RAPSVA VGS CDL+LKIPEI+ DM+A VTSPSG+ EAEIV
Sbjct: 2127 TGEGRVKESITRRRRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKTHEAEIVEGE 2186
Query: 2150 KNSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGPGLERGEAG 2209
+++C+RFVP EMG HTVSVKY+GQHV GSPFQFTVGPLGEGGAHKVRAGGPGLER EAG
Sbjct: 2187 NHTYCIRFVPAEMGTHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGPGLERAEAG 2246
Query: 2210 VPAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYEVSIKFNDE 2269
VPAEFSIWTREAGAGGL+IAVEGPSKAEI+F+D K+GSCGV+Y+ QEPG+YEVS+KFN+E
Sbjct: 2247 VPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYEVSVKFNEE 2306
Query: 2270 HIPESPYLVPVIAPSDDARRLTVMSLQESGLKVNQPASFAIRLNGAKGKIDAKVHSPSGA 2329
HIP+SP++VPV +PS DARRLTV SLQESGLKVNQPASFA+ LNGAKG IDAKVHSPSGA
Sbjct: 2307 HIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDAKVHSPSGA 2366
Query: 2330 VEECHVSELEPDKYAVRFIPHENGVHTIDVKFNGSHVVGSPFKVRVGEPGQAGNPALVSA 2389
+EEC+V+E++ DKYAVRFIP ENGV+ IDVKFNG+H+ GSPFK+RVGEPG G+P LVSA
Sbjct: 2367 LEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHGGDPGLVSA 2426
Query: 2390 YGTGLEGGTTGIQSEFFINTTRAGPGTLSVTIEGPSKVKMDCQETPEGYKVMYTPMAPGN 2449
YG GLEGG TG +EF +NT+ AG G LSVTI+GPSKVKMDCQE PEGY+V YTPMAPG+
Sbjct: 2427 YGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVTYTPMAPGS 2486
Query: 2450 YLISVKYGGPNHIVGSPFKAKVTGQRLVSPGSANETSSILVESVTRSSTETCYSAIPKAS 2509
YLIS+KYGGP HI GSPFKAKVTG RLVS S +ETSS+ V+S+T+++ + A
Sbjct: 2487 YLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQHGAPGPGP 2546
Query: 2510 SDASKVTSKGAGLSKAFVGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSMKHVGNQQY 2569
+DASKV +KG GLSKA+VGQKSSF VDCSKAG+NMLL+GVHGP TPCEE+ +KHVG++ Y
Sbjct: 2547 ADASKVVAKGLGLSKAYVGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILVKHVGSRLY 2606
Query: 2570 NVTYVVKERGDYVLAVKWGEEHIPGSPFHVTVP 2602
+V+Y++K++G+Y L VKWG+EHIPGSP+ V VP
Sbjct: 2607 SVSYLLKDKGEYTLVVKWGDEHIPGSPYRVVVP 2639
>gi|160420317 filamin A, alpha isoform 2 [Homo sapiens]
Length = 2647
Score = 3795 bits (9841), Expect = 0.0
Identities = 1827/2621 (69%), Positives = 2164/2621 (82%), Gaps = 20/2621 (0%)
Query: 1 MPVTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQK 60
MP TEKDLAEDAPWKKIQQNTFTRWCNEHLKCV+KRI NLQTDLSDGLRLIALLEVLSQK
Sbjct: 28 MPATEKDLAEDAPWKKIQQNTFTRWCNEHLKCVSKRIANLQTDLSDGLRLIALLEVLSQK 87
Query: 61 RMYRKYHQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILH 120
+M+RK++QRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGL+WTLILH
Sbjct: 88 KMHRKHNQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLIWTLILH 147
Query: 121 YSISMPVWEDEGDDDAKKQTPKQRLLGWIQNKIPYLPITNFNQNWQDGKALGALVDSCAP 180
YSISMP+W++E D++AKKQTPKQRLLGWIQNK+P LPITNF+++WQ G+ALGALVDSCAP
Sbjct: 148 YSISMPMWDEEEDEEAKKQTPKQRLLGWIQNKLPQLPITNFSRDWQSGRALGALVDSCAP 207
Query: 181 GLCPDWESWDPQKPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLSQFPKA 240
GLCPDW+SWD KPV NAREAMQQADDWLG+PQVITPEEI+ P+VDEHSVMTYLSQFPKA
Sbjct: 208 GLCPDWDSWDASKPVTNAREAMQQADDWLGIPQVITPEEIVDPNVDEHSVMTYLSQFPKA 267
Query: 241 KLKPGAPLKPKLNPKKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGNK 300
KLKPGAPL+PKLNPKKARAYG GIEPTGNMVK+ A+FTV+T SAGQG+V+V+VEDP G++
Sbjct: 268 KLKPGAPLRPKLNPKKARAYGPGIEPTGNMVKKRAEFTVETRSAGQGEVLVYVEDPAGHQ 327
Query: 301 EEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVSVDKAQGDASKVTAK 360
EEA+VT ++DKN+T+SV Y+P+VTG HKVTVLFAGQHI+KSPFEV VDK+QGDASKVTA+
Sbjct: 328 EEAKVTANNDKNRTFSVWYVPEVTGTHKVTVLFAGQHIAKSPFEVYVDKSQGDASKVTAQ 387
Query: 361 GPGLEAVGNIANKPTYFDIYTAGAGVGDIGVEVEDPQG-KNTVELLVEDKGNQVYRCVYK 419
GPGLE GNIANK TYF+I+TAGAG G++ V ++DP G K TVE +E +G+ YRC Y+
Sbjct: 388 GPGLEPSGNIANKTTYFEIFTAGAGTGEVEVVIQDPMGQKGTVEPQLEARGDSTYRCSYQ 447
Query: 420 PMQPGPHVVKIFFAGDTIPKSPFVVQVGEACNPNACRASGRGLQPKGVRIRETTDFKVDT 479
P G H V + FAG IP+SP+ V VG+ACNP+ACRA GRGLQPKGVR++ET DFKV T
Sbjct: 448 PTMEGVHTVHVTFAGVPIPRSPYTVTVGQACNPSACRAVGRGLQPKGVRVKETADFKVYT 507
Query: 480 KAAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITWGGHHIPKSPF 539
K AGSGEL VT+KGPKG EE VKQKD DGVY FEYYP PG Y + ITWGG +I +SPF
Sbjct: 508 KGAGSGELKVTVKGPKG-EERVKQKDLGDGVYGFEYYPMVPGTYIVTITWGGQNIGRSPF 566
Query: 540 EVQVGPEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYNDQ 599
EV+VG E G QKVRAWGPGL GG+VG+SADFVVE+IG +VG+LGF++EGPSQAKIE +D+
Sbjct: 567 EVKVGTECGNQKVRAWGPGLEGGVVGKSADFVVEAIGDDVGTLGFSVEGPSQAKIECDDK 626
Query: 600 NDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGYNPDLVRAYGPGLEKSG 659
DGSCDV+YWP+E GEYAVH++C+ EDI+ SP+MA I A ++PD V+A GPGLEK+G
Sbjct: 627 GDGSCDVRYWPQEAGEYAVHVLCNSEDIRLSPFMADIRDAPQDFHPDRVKARGPGLEKTG 686
Query: 660 CIVNNLAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGTYACSYTPVKAIKHTIA 719
VN AEFTVD K GKAPL++ QD EG ++ +K+ +GTY+CSY P K +KHT
Sbjct: 687 VAVNKPAEFTVDAKHGGKAPLRVQVQDNEGCPVEALVKDNGNGTYSCSYVPRKPVKHTAM 746
Query: 720 VVWGGVNIPHSPYRVNIGQGSHPQKVKVFGPGVERSGLKANEPTHFTVDCTEAGEGDVSV 779
V WGGV+IP+SP+RVN+G GSHP KVKV+GPGV ++GLKA+EPT+FTVDC EAG+GDVS+
Sbjct: 747 VSWGGVSIPNSPFRVNVGAGSHPNKVKVYGPGVAKTGLKAHEPTYFTVDCAEAGQGDVSI 806
Query: 780 GIKCDARVLSEDEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPASPFRVKV 839
GIKC V+ E D+DFDII N NDTFTVKY P AG YTI VLFA Q P SP RVKV
Sbjct: 807 GIKCAPGVVGPAEADIDFDIIRNDNDTFTVKYTPRGAGSYTIMVLFADQATPTSPIRVKV 866
Query: 840 DPSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFNSPLPGDAVKDLDII 899
+PSHDASKVKAEGPGLS+ GVE GKPTHFTV K AGK L+VQF+ GDAV+D+DII
Sbjct: 867 EPSHDASKVKAEGPGLSRTGVELGKPTHFTVNAKAAGKGKLDVQFSGLTKGDAVRDVDII 926
Query: 900 DNYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTVGVAAPLDLSKIKLNGLENRVEVG 959
D++D ++TVKYTP QQG + V VTYGGDPIPKSPF+V V+ LDLSKIK++GL +V+VG
Sbjct: 927 DHHDNTYTVKYTPVQQGPVGVNVTYGGDPIPKSPFSVAVSPSLDLSKIKVSGLGEKVDVG 986
Query: 960 KDQEFTVDTRGAGGQGKLDVTILSPSRKVVPCLVTPVTGRENSTAKFIPREEGLYAVDVT 1019
KDQEFTV ++GAGGQGK+ I+ PS VPC V P G +NS +F+PREEG Y V+VT
Sbjct: 987 KDQEFTVKSKGAGGQGKVASKIVGPSGAAVPCKVEPGLGADNSVVRFLPREEGPYEVEVT 1046
Query: 1020 YDGHPVPGSPYTVEASLPPDPSKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTVEG 1079
YDG PVPGSP+ +EA P PSKVKA GPGL+GG G PA FTIDTKGAGTGGLGLTVEG
Sbjct: 1047 YDGVPVPGSPFPLEAVAPTKPSKVKAFGPGLQGGSAGSPARFTIDTKGAGTGGLGLTVEG 1106
Query: 1080 PCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVAS 1139
PCEA++EC DNGDGTCSVSY+PT+PG+Y +NILF + HIPGSPFKA + FD SKV S
Sbjct: 1107 PCEAQLECLDNGDGTCSVSYVPTEPGDYNINILFADTHIPGSPFKAHVVPCFDASKVKCS 1166
Query: 1140 GPGLEHGKVGEAGLLSVDCSEAGPGALGLEAVSDSGTKAEVSIQNNKDGTYAVTYVPLTA 1199
GPGLE GE G VDCS AG L +E S++G AEV IQ++ DGT+ +TY+PL
Sbjct: 1167 GPGLERATAGEVGQFQVDCSSAGSAELTIEICSEAGLPAEVYIQDHGDGTHTITYIPLCP 1226
Query: 1200 GMYTLTMKYGGELVPHFPARVKVEPAVDTSRIKVFGPGIEGKDVFREATTDFTVDSRPLT 1259
G YT+T+KYGG+ VP+FP++++VEPAVDTS ++ +GPGIEG+ VFREATT+F+VD+R LT
Sbjct: 1227 GAYTVTIKYGGQPVPNFPSKLQVEPAVDTSGVQCYGPGIEGQGVFREATTEFSVDARALT 1286
Query: 1260 QVGGDHIKAHIANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPIPNSPFK 1319
Q GG H+KA +ANPSG TE +V D DG Y+VEYTP+E+GLH V+VTYD P+P+SPF+
Sbjct: 1287 QTGGPHVKARVANPSGNLTETYVQDRGDGMYKVEYTPYEEGLHSVDVTYDGSPVPSSPFQ 1346
Query: 1320 VAVTEGCQPSRVQAQGPGLKEAFTNKPNVFTVVTRGAGIGGLGITVEGPSESKINCRDNK 1379
V VTEGC PSRV+ GPG++ TNKPN FTV TRGAG GGLG+ VEGPSE+K++C DNK
Sbjct: 1347 VPVTEGCDPSRVRVHGPGIQSGTTNKPNKFTVETRGAGTGGLGLAVEGPSEAKMSCMDNK 1406
Query: 1380 DGSCSAEYIPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVDPSKVKIAGPGLGSG-VRAR 1438
DGSCS EYIP+ G Y +N+TYGG +PGSPF+VPV DV D SKVK +GPGL G VRA
Sbjct: 1407 DGSCSVEYIPYEAGTYSLNVTYGGHQVPGSPFKVPVHDVTDASKVKCSGPGLSPGMVRAN 1466
Query: 1439 VLQSFTVDSSKAGLAPLEVRVLGPRGLVEPVNVVDNGDGTHTVTYTPSQEGPYMVSVKYA 1498
+ QSF VD+SKAG+APL+V+V GP+GLVEPV+VVDN DGT TV Y PS+EGPY +SV Y
Sbjct: 1467 LPQSFQVDTSKAGVAPLQVKVQGPKGLVEPVDVVDNADGTQTVNYVPSREGPYSISVLYG 1526
Query: 1499 DEEIPRSPFKVKVLPTYDASKVTASGPGLSSYGVPASLPVDFAIDARDAGEGLLAVQITD 1558
DEE+PRSPFKVKVLPT+DASKV ASGPGL++ GVPASLPV+F IDA+DAGEGLLAVQITD
Sbjct: 1527 DEEVPRSPFKVKVLPTHDASKVKASGPGLNTTGVPASLPVEFTIDAKDAGEGLLAVQITD 1586
Query: 1559 QEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGVTYGGDDIPLSPYRIRATQTGDASKCL 1618
EGKPK+ + DN DGTY V Y+PD TGRY I + YGGD+IP SPYR+RA TGDASKC
Sbjct: 1587 PEGKPKKTHIQDNHDGTYTVAYVPDVTGRYTILIKYGGDEIPFSPYRVRAVPTGDASKCT 1646
Query: 1619 AT--------GPGIASTVKTGEEVGFVVDAKTAGKGKVTCTVLTPDGTEAEADVIENEDG 1670
T G GI T++ GEE VD K AGKGKVTCTV TPDG+E + DV+ENEDG
Sbjct: 1647 VTVSIGGHGLGAGIGPTIQIGEETVITVDTKAAGKGKVTCTVCTPDGSEVDVDVVENEDG 1706
Query: 1671 TYDIFYTAAKPGTYVIYVRFGGVDIPNSPFTVMATDGEVTAVEE-------AP-VNACPP 1722
T+DIFYTA +PG YVI VRFGG +PNSPF V A G+ +V+ AP
Sbjct: 1707 TFDIFYTAPQPGKYVICVRFGGEHVPNSPFQVTALAGDQPSVQPPLRSQQLAPQYTYAQG 1766
Query: 1723 GFRPWVTEEAYVPVSDMNGLGFKPFDLVIPFAVRKGEITGEVHMPSGKTATPEIVDNKDG 1782
G + W E V V+ ++ +PFDLVIPF ++KGEITGEV MPSGK A P I DNKDG
Sbjct: 1767 GQQTWAPERPLVGVNGLDVTSLRPFDLVIPFTIKKGEITGEVRMPSGKVAQPTITDNKDG 1826
Query: 1783 TVTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVSAYGPGLVYGVANKTATF 1842
TVTVRYAP+E GLHEM I+Y HIP SPLQFYV+Y N G V+AYGPGL +GV NK ATF
Sbjct: 1827 TVTVRYAPSEAGLHEMDIRYDNMHIPGSPLQFYVDYVNCGHVTAYGPGLTHGVVNKPATF 1886
Query: 1843 TIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGS 1902
T+ T+DAGEGGL LAIEGPSKAEISC DN+DGTC+V+YLP LPGDYSILVKYN++H+PGS
Sbjct: 1887 TVNTKDAGEGGLSLAIEGPSKAEISCTDNQDGTCSVSYLPVLPGDYSILVKYNEQHVPGS 1946
Query: 1903 PFTAKIT-DDSRRCSQVKLGSAADFLLDISETDLSSLTASIKAPSGRDEPCLLKRLPNNH 1961
PFTA++T DDS R S +K+GSAAD ++ISETDLS LTA++ PSGR+EPCLLKRL N H
Sbjct: 1947 PFTARVTGDDSMRMSHLKVGSAADIPINISETDLSLLTATVVPPSGREEPCLLKRLRNGH 2006
Query: 1962 IGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFEMS 2021
+GISF+P+E GEHLV +KKNG HVA+SP+ +++ QSEIGDA R +V G+GL EG TFE +
Sbjct: 2007 VGISFVPKETGEHLVHVKKNGQHVASSPIPVVISQSEIGDASRVRVSGQGLHEGHTFEPA 2066
Query: 2022 DFIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVP 2081
+FI+DTRDAGYGG+SL++EGPSKVDI TEDLEDGTC+V+Y PT PG YI++ KFAD+HVP
Sbjct: 2067 EFIIDTRDAGYGGLSLSIEGPSKVDINTEDLEDGTCRVTYCPTEPGNYIINIKFADQHVP 2126
Query: 2082 GSPFTVKISGEGRVKESITRTSRAPSVATVGSICDLNLKIPEINSSDMSAHVTSPSGRVT 2141
GSPF+VK++GEGRVKESITR RAPSVA VGS CDL+LKIPEI+ DM+A VTSPSG+
Sbjct: 2127 GSPFSVKVTGEGRVKESITRRRRAPSVANVGSHCDLSLKIPEISIQDMTAQVTSPSGKTH 2186
Query: 2142 EAEIVPMGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGP 2201
EAEIV +++C+RFVP EMG HTVSVKY+GQHV GSPFQFTVGPLGEGGAHKVRAGGP
Sbjct: 2187 EAEIVEGENHTYCIRFVPAEMGTHTVSVKYKGQHVPGSPFQFTVGPLGEGGAHKVRAGGP 2246
Query: 2202 GLERGEAGVPAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYE 2261
GLER EAGVPAEFSIWTREAGAGGL+IAVEGPSKAEI+F+D K+GSCGV+Y+ QEPG+YE
Sbjct: 2247 GLERAEAGVPAEFSIWTREAGAGGLAIAVEGPSKAEISFEDRKDGSCGVAYVVQEPGDYE 2306
Query: 2262 VSIKFNDEHIPESPYLVPVIAPSDDARRLTVMSLQESGLKVNQPASFAIRLNGAKGKIDA 2321
VS+KFN+EHIP+SP++VPV +PS DARRLTV SLQESGLKVNQPASFA+ LNGAKG IDA
Sbjct: 2307 VSVKFNEEHIPDSPFVVPVASPSGDARRLTVSSLQESGLKVNQPASFAVSLNGAKGAIDA 2366
Query: 2322 KVHSPSGAVEECHVSELEPDKYAVRFIPHENGVHTIDVKFNGSHVVGSPFKVRVGEPGQA 2381
KVHSPSGA+EEC+V+E++ DKYAVRFIP ENGV+ IDVKFNG+H+ GSPFK+RVGEPG
Sbjct: 2367 KVHSPSGALEECYVTEIDQDKYAVRFIPRENGVYLIDVKFNGTHIPGSPFKIRVGEPGHG 2426
Query: 2382 GNPALVSAYGTGLEGGTTGIQSEFFINTTRAGPGTLSVTIEGPSKVKMDCQETPEGYKVM 2441
G+P LVSAYG GLEGG TG +EF +NT+ AG G LSVTI+GPSKVKMDCQE PEGY+V
Sbjct: 2427 GDPGLVSAYGAGLEGGVTGNPAEFVVNTSNAGAGALSVTIDGPSKVKMDCQECPEGYRVT 2486
Query: 2442 YTPMAPGNYLISVKYGGPNHIVGSPFKAKVTGQRLVSPGSANETSSILVESVTRSSTETC 2501
YTPMAPG+YLIS+KYGGP HI GSPFKAKVTG RLVS S +ETSS+ V+S+T+++
Sbjct: 2487 YTPMAPGSYLISIKYGGPYHIGGSPFKAKVTGPRLVSNHSLHETSSVFVDSLTKATCAPQ 2546
Query: 2502 YSAIPKASSDASKVTSKGAGLSKAFVGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSM 2561
+ A +DASKV +KG GLSKA+VGQKSSF VDCSKAG+NMLL+GVHGP TPCEE+ +
Sbjct: 2547 HGAPGPGPADASKVVAKGLGLSKAYVGQKSSFTVDCSKAGNNMLLVGVHGPRTPCEEILV 2606
Query: 2562 KHVGNQQYNVTYVVKERGDYVLAVKWGEEHIPGSPFHVTVP 2602
KHVG++ Y+V+Y++K++G+Y L VKWG+EHIPGSP+ V VP
Sbjct: 2607 KHVGSRLYSVSYLLKDKGEYTLVVKWGDEHIPGSPYRVVVP 2647
>gi|116805322 gamma filamin isoform a [Homo sapiens]
Length = 2725
Score = 3205 bits (8310), Expect = 0.0
Identities = 1620/2647 (61%), Positives = 1958/2647 (73%), Gaps = 121/2647 (4%)
Query: 1 MPVTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQK 60
MP TEKDLAEDAPWKKIQQNTFTRWCNEHLKCV KR+ +LQ DLSDGLRLIALLEVLSQK
Sbjct: 21 MPSTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVGKRLTDLQRDLSDGLRLIALLEVLSQK 80
Query: 61 RMYRKYHQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILH 120
RMYRK+H RP FRQM+LENVSVALEFL+RE IKLVSIDSKAIVDGNLKLILGL+WTLILH
Sbjct: 81 RMYRKFHPRPNFRQMKLENVSVALEFLEREHIKLVSIDSKAIVDGNLKLILGLIWTLILH 140
Query: 121 YSISMPVWEDEGDDDAKKQTPKQRLLGWIQNKIPYLPITNFNQNWQDGKALGALVDSCAP 180
YSISMP+WEDE D+DA+KQTPKQRLLGWIQNK+P LPITNFN++WQDGKALGALVD+CAP
Sbjct: 141 YSISMPMWEDEDDEDARKQTPKQRLLGWIQNKVPQLPITNFNRDWQDGKALGALVDNCAP 200
Query: 181 GLCPDWESWDPQKPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLSQFPKA 240
GLCPDWE+WDP +PV+NAREAMQQADDWLGVPQVI PEEI+ P+VDEHSVMTYLSQFPKA
Sbjct: 201 GLCPDWEAWDPNQPVENAREAMQQADDWLGVPQVIAPEEIVDPNVDEHSVMTYLSQFPKA 260
Query: 241 KLKPGAPLKPK-LNPKKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGN 299
KLKPGAP++ K LNPKKA AYG GIEP GN V QPA FTV T+ AG G+V+V++EDPEG+
Sbjct: 261 KLKPGAPVRSKQLNPKKAIAYGPGIEPQGNTVLQPAHFTVQTVDAGVGEVLVYIEDPEGH 320
Query: 300 KEEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVSVDKAQGDASKVTA 359
EEA+V P++DK++TY+V Y+PKV GLHKVTVLFAGQ+I +SPFEV+V A GDA+KV+A
Sbjct: 321 TEEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSA 380
Query: 360 KGPGLEAVGNIANKPTYFDIYTAGAGVGDIGVEVEDPQGK-NTVELLVEDKGNQVYRCVY 418
+GPGLE VGN+ANKPTYFDIYTAGAG GD+ V + DPQG+ +TVE+ +EDKG+ +RC Y
Sbjct: 381 RGPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTY 440
Query: 419 KPMQPGPHVVKIFFAGDTIPKSPFVVQVGEACNPNACRASGRGLQPKGVRIRETTDFKVD 478
+P GPH V + FAG I +SPF V V EACNPNACRASGRGLQPKGVR++E DFKV
Sbjct: 441 RPAMEGPHTVHVAFAGAPITRSPFPVHVSEACNPNACRASGRGLQPKGVRVKEVADFKVF 500
Query: 479 TKAAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITWGGHHIPKSP 538
TK AGSGEL VT+KGPKG EE VK ++ DGV+ EYYP PG+Y + ITWGG+ IP+SP
Sbjct: 501 TKGAGSGELKVTVKGPKGTEEPVKVREAGDGVFECEYYPVVPGKYVVTITWGGYAIPRSP 560
Query: 539 FEVQVGPEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYND 598
FEVQV PEAG+QKVRAWGPGL G VG+SADFVVE+IG+EVG+LGF+IEGPSQAKIE +D
Sbjct: 561 FEVQVSPEAGVQKVRAWGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKIECDD 620
Query: 599 QNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGYNPDLVRAYGPGLEKS 658
+ DGSCDV+YWP EPGEYAVH++CDDEDI+DSP++A I PA PD V+A+GPGLE +
Sbjct: 621 KGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHILPAPPDCFPDKVKAFGPGLEPT 680
Query: 659 GCIVNNLAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGTYACSYTPVKAIKHTI 718
GCIV+ AEFT+D + AGK LK++AQD +G IDI++ DGT+ CSY P K IKHTI
Sbjct: 681 GCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTI 740
Query: 719 AVVWGGVNIPHSPYRVNIGQGSHPQKVKVFGPGVERSGLKANEPTHFTVDCTEAGEGDVS 778
+ WGGVN+P SP+RVN+G+GSHP++VKV+GPGVE++GLKANEPT+FTVDC+EAG+GDVS
Sbjct: 741 IISWGGVNVPKSPFRVNVGEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVS 800
Query: 779 VGIKCDARVLSEDEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPASPFRVK 838
+GIKC V+ E D+DFDII N NDTFTVKY PP AGRYTI VLFA+QEIPASPF +K
Sbjct: 801 IGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIK 860
Query: 839 VDPSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFNSPLPGDAVKDLDI 898
VDPSHDASKVKAEGPGL++ GVE GKPTHFTV TKGAGKA L+VQF G+ V+D +I
Sbjct: 861 VDPSHDASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVQFAGTAKGEVVRDFEI 920
Query: 899 IDNYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTVGVAAPLDLSKIKLNGLENRVEV 958
IDN+DYS+TVKYT QQGNM V VTYGGDP+PKSPF V VA PLDLSKIK+ GL ++V V
Sbjct: 921 IDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPPLDLSKIKVQGLNSKVAV 980
Query: 959 GKDQEFTVDTRGAGGQGKLDVTILSPSRKVVPCLVTPVTGRENSTAKFIPREEGLYAVDV 1018
G++Q F+V+TRGAGGQG+LDV + SPSR+ +PC + P G E +++P EEG Y VD+
Sbjct: 981 GQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGGGAEAQAVRYMPPEEGPYKVDI 1040
Query: 1019 TYDGHPVPGSPYTVEASLPPDPSKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTVE 1078
TYDGHPVPGSP+ VE LPPDPSKV A+GPGL+GGLVG PA F+IDTKGAGTGGLGLTVE
Sbjct: 1041 TYDGHPVPGSPFAVEGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVE 1100
Query: 1079 GPCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVA 1138
GPCEAKIEC DNGDG+C+VSYLPT+PGEY +NILF E HIPGSPFKA I FDPSKV A
Sbjct: 1101 GPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIRPVFDPSKVRA 1160
Query: 1139 SGPGLEHGKVGEAGLLSVDCSEAGPGALGLEAVSDSGTKAEVSIQNNKDGTYAVTYVPLT 1198
SGPGLE GKVGEA +VDCSEAG L +E +SD+G KAEV I NN DGTY +TY P
Sbjct: 1161 SGPGLERGKVGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAF 1220
Query: 1199 AGMYTLTMKYGGELVPHFPARVKVEPAVDTSRIKVFGPGIEGKDVFREATTDFTVDSRPL 1258
G YT+T+KYGG VP FP RV V+PAVDTS +KV GPG+E V RE TT+FTVD+R L
Sbjct: 1221 PGTYTITIKYGGHPVPKFPTRVHVQPAVDTSGVKVSGPGVEPHGVLREVTTEFTVDARSL 1280
Query: 1259 TQVGGDHIKAHIANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPIPNSPF 1318
T GG+H+ A + NPSGA T+ +VTDN DGTY+V+YT +E+G+H+VEV YD+V +P SPF
Sbjct: 1281 TATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEVLYDEVAVPKSPF 1340
Query: 1319 KVAVTEGCQPSRVQAQGPGLKEAFTNKPNVFTVVTRGAGIGGLGITVEGPSESKINCRDN 1378
+V VTEGC P+RV+A GPGL+ NK N FTV TRGAG GGLG+ +EGPSE+K++C+DN
Sbjct: 1341 RVGVTEGCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSCKDN 1400
Query: 1379 KDGSCSAEYIPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVDPSKVKIAGPGLGSGVRAR 1438
KDGSC+ EYIPF PGDYDVNIT+GG IPGSPFRVPVKDVVDP KVK +GPGLG+GVRAR
Sbjct: 1401 KDGSCTVEYIPFTPGDYDVNITFGGRPIPGSPFRVPVKDVVDPGKVKCSGPGLGAGVRAR 1460
Query: 1439 VLQSFTVDSSKAGLAPLEVRVLGPRGLVEPVNVVDNGDGTHTVTYTPSQEGPYMVSVKYA 1498
V Q+FTVD S+AG APL+V VLGP G+ EPV V DNGDGTHTV YTP+ +GPY V+VKYA
Sbjct: 1461 VPQTFTVDCSQAGRAPLQVAVLGPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYA 1520
Query: 1499 DEEIPRSPFKVKVLPTYDASKVTASGPGLSSYGVPASLPVDFAIDARDAGEGLLAVQITD 1558
D+E+PRSPFK+KVLP +DASKV ASGPGL++ G+PASLPV+F IDARDAGEGLL VQI D
Sbjct: 1521 DQEVPRSPFKIKVLPAHDASKVRASGPGLNASGIPASLPVEFTIDARDAGEGLLTVQILD 1580
Query: 1559 QEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGVTYGGDDIPLSPYRIRATQTGDASKCL 1618
EGKPK+A + DN DGTY V+Y+PD +GRY I + YGGD+IP SP+RI A TGDASKCL
Sbjct: 1581 PEGKPKKANIRDNGDGTYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCL 1640
Query: 1619 AT--------GPGIASTVKTGEEVGFVVDAKTAGKGKVTCTVLTPDGTEAEADVIENEDG 1670
T G + ++ G+E VDAK AG+GKVTCTV TPDG E + DV+EN DG
Sbjct: 1641 VTVSIGGHGLGACLGPRIQIGQETVITVDAKAAGEGKVTCTVSTPDGAELDVDVVENHDG 1700
Query: 1671 TYDIFYTAAKPGTYVIYVRFGGVDIPNSPFTVMATD--------GEVTAVEEAPVNACPP 1722
T+DI+YTA +PG YVI +RFGG IPNSPF V+A D EV + + P P
Sbjct: 1701 TFDIYYTAPEPGKYVITIRFGGEHIPNSPFHVLACDPLPHEEEPSEVPQLRQ-PYAPPRP 1759
Query: 1723 GFRP--WVTEEAYVPVSDMNGLGFKPFDLVIPFAVRKGEITGEVHMPSGKTATPEIVDNK 1780
G RP W TEE VPV M + +PF+LVIPFAV+KGE+TGEV MPSGKTA P I DNK
Sbjct: 1760 GARPTHWATEEPVVPVEPMESM-LRPFNLVIPFAVQKGELTGEVRMPSGKTARPNITDNK 1818
Query: 1781 DGTVTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVSAYGPGLVYGVANKTA 1840
DGT+TVRYAPTE GLH+M IKY G+HIP SPLQFYV+ NS VSAYGPGL +G+ NK A
Sbjct: 1819 DGTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRHVSAYGPGLSHGMVNKPA 1878
Query: 1841 TFTIVTEDAGEGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIP 1900
TFTIVT+DAGEGGL LA+EGPSKAEI+C DNKDGTCTV+YLPT PGDYSI+V+++DKHIP
Sbjct: 1879 TFTIVTKDAGEGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIP 1938
Query: 1901 GSPFTAKIT-DDSRRCSQVKLGSAADFLLDISETDLSSLTASIKAPSGRDEPCLLKRLPN 1959
GSPFTAKIT DDS R SQ+ +G++ D L I+E+DLS LTASI+APSG +EPCLLKRLPN
Sbjct: 1939 GSPFTAKITGDDSMRTSQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEEPCLLKRLPN 1998
Query: 1960 NHIGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFE 2019
HIGISF P+EVGEH+VS++K+G HV NSP I+V SEIGDA + +V+G+GLSEG TF+
Sbjct: 1999 RHIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGHTFQ 2058
Query: 2020 MSDFIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEH 2079
+++FIVDTR+AGYGG+ L++EGPSKVDI ED+EDGTCKV+Y PT PG YI++ KFAD+H
Sbjct: 2059 VAEFIVDTRNAGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKH 2118
Query: 2080 VPGSPFTVKISGEGRVKESITRTSRAPSVATVGSICDLNLKIP-----EINSSDMSAHVT 2134
VPGSPFTVK++GEGR+KESITR +APS+AT+GS CDLNLKIP +++ +
Sbjct: 2119 VPGSPFTVKVTGEGRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTF 2178
Query: 2135 SPSGRV---TEAEIVPMGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEG 2191
+ S TE + + R V E V G PF G
Sbjct: 2179 TRSSHTYTRTERTEISKTRGGETKREVRVE----------ESTQVGGDPFPAVFGDF--- 2225
Query: 2192 GAHKVRAGGPG-LERGEAGVPAEFSIWTREAGAGGLSIAVEGPS----KAEITFDDHKNG 2246
+ R G G + R + G EA + ++ V PS AEI + ++
Sbjct: 2226 -LGRERLGSFGSITRQQEG----------EASSQDMTAQVTSPSGKVEAAEIV--EGEDS 2272
Query: 2247 SCGVSYIAQEPGNYEVSIKFNDEHIPESPYLVPVIAPSDDARRLTVMSLQESGLK---VN 2303
+ V ++ QE G + V++K+ +H+P SP+ + P + V + +GL+
Sbjct: 2273 AYSVRFVPQEMGPHTVAVKYRGQHVPGSPFQF-TVGPLGEGGAHKVRA-GGTGLERGVAG 2330
Query: 2304 QPASFAIRLNGA-KGKIDAKVHSPSGAVEECHVSELEPDKYAVRFIPHENGVHTIDVKFN 2362
PA F+I A G + V PS A E + + V ++ E G + + +KFN
Sbjct: 2331 VPAEFSIWTREAGAGGLSIAVEGPSKA--EIAFEDRKDGSCGVSYVVQEPGDYEVSIKFN 2388
Query: 2363 GSHVVGSPFKVRVGE-PGQAGNPALVSAYGTGLEGGTTGIQSEFFINTTRAGPGTLSVTI 2421
H+ SPF V V A + S TGL+ Q F G + +
Sbjct: 2389 DEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVN----QPASFAVQLNGARGVIDARV 2444
Query: 2422 EGPSKVKMDC---QETPEGYKVMYTPMAPGNYLISVKYGGPNHIVGSPFKAKVTGQRLVS 2478
PS +C + + + + + P G + I VK+ G HI GSPFK +V Q
Sbjct: 2445 HTPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGA-HIPGSPFKIRVGEQ---- 2499
Query: 2479 PGSANETSSILVESVTRSSTETCYSAIPKASSDASKVTSKGAGLSKAFVGQKSSFLVDCS 2538
+ D V++ G GL G S F+V+
Sbjct: 2500 ----------------------------SQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTL 2531
Query: 2539 KAGSNMLLIGVHGPT---TPCEEVSMKHVGNQQYNVTYVVKERGDYVLAVKW-GEEHIPG 2594
AGS L + + GP+ C E HV VTY G+Y++A+K+ G +HI G
Sbjct: 2532 NAGSGALSVTIDGPSKVQLDCRECPEGHV------VTYTPMAPGNYLIAIKYGGPQHIVG 2585
Query: 2595 SPFHVTV 2601
SPF V
Sbjct: 2586 SPFKAKV 2592
Score = 1523 bits (3944), Expect = 0.0
Identities = 954/2440 (39%), Positives = 1334/2440 (54%), Gaps = 184/2440 (7%)
Query: 256 KARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGNKEEAQVTPDSDKNKTY 315
K A G G+EP GN+ +P F + T AG GDV V + DP+G ++ +V + + T+
Sbjct: 377 KVSARGPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDSTF 436
Query: 316 SVEYLPKVTGLHKVTVLFAGQHISKSPFEVSVDKAQGDASKVTAKGPGLEAVGNIANKPT 375
Y P + G H V V FAG I++SPF V V +A + + A G GL+ G +
Sbjct: 437 RCTYRPAMEGPHTVHVAFAGAPITRSPFPVHVSEAC-NPNACRASGRGLQPKGVRVKEVA 495
Query: 376 YFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDKGNQVYRCVYKPMQPGPHVVKIFFAGD 435
F ++T GAG G++ V V+ P+G + V + G+ V+ C Y P+ PG +VV I + G
Sbjct: 496 DFKVFTKGAGSGELKVTVKGPKGTEE-PVKVREAGDGVFECEYYPVVPGKYVVTITWGGY 554
Query: 436 TIPKSPFVVQVGEACNPNACRASGRGLQPKGVRIRETTDFKVDTKAAGSGELGVTMKGPK 495
IP+SPF VQV RA G GL+ ++ ++ DF V+ G LG +++GP
Sbjct: 555 AIPRSPFEVQVSPEAGVQKVRAWGPGLETG--QVGKSADFVVEAIGTEVGTLGFSIEGPS 612
Query: 496 GLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITWGGHHIPKSPFEVQV---GPEAGMQKV 552
+ ++ D DG Y+P+ PG Y++ + I SPF + P+ KV
Sbjct: 613 --QAKIECDDKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHILPAPPDCFPDKV 670
Query: 553 RAWGPGLH--GGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYN--DQNDGSCDVKY 608
+A+GPGL G IV + A+F +++ + G L + I+ DG+ Y
Sbjct: 671 KAFGPGLEPTGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSY 730
Query: 609 WPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGYNPDLVRAYGPGLEKSGCIVNNLAEF 668
P +P ++ + I ++ SP+ + G +P+ V+ YGPG+EK+G N F
Sbjct: 731 VPTKPIKHTIIISWGGVNVPKSPFRVNVGE---GSHPERVKVYGPGVEKTGLKANEPTYF 787
Query: 669 TVDPKDAGKAPLKIFAQDGEG------QRIDIQMKNRMDGTYACSYTPVKAIKHTIAVVW 722
TVD +AG+ + I + G ID + + T+ YTP A ++TI V++
Sbjct: 788 TVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLF 847
Query: 723 GGVNIPHSPYRVNIGQGSHPQKVKVFGPGVERSGLKANEPTHFTVDCTEAGEGDVSVGIK 782
IP SP+ + + KVK GPG+ R+G++ +PTHFTV AG+ + V
Sbjct: 848 ANQEIPASPFHIKVDPSHDASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVQFA 907
Query: 783 CDARVLSEDEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPASPFRVKVDPS 842
A+ E DF+II N + ++TVKY G + V + +P SPF V V P
Sbjct: 908 GTAK----GEVVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPP 963
Query: 843 HDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAG-KAPLNVQFNSPLPGDAVKDLDIIDN 901
D SK+K +G SK V G+ F+V T+GAG + L+V+ SP L+
Sbjct: 964 LDLSKIKVQGLN-SKVAV--GQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGGG 1020
Query: 902 YDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTVGVAAPLDLSKIKLNG--LENRVEVG 959
+ + V+Y P ++G +V +TY G P+P SPF V P D SK+ G L+ + VG
Sbjct: 1021 AE-AQAVRYMPPEEGPYKVDITYDGHPVPGSPFAVEGVLPPDPSKVCAYGPGLKGGL-VG 1078
Query: 960 KDQEFTVDTRGAGGQGKLDVTILSPSRKVVPCLVTPVTGRENSTAKFIPREEGLYAVDVT 1019
F++DT+GAG G L +T+ P + C G + ++P E G Y +++
Sbjct: 1079 TPAPFSIDTKGAG-TGGLGLTVEGPCEAKIEC---QDNGDGSCAVSYLPTEPGEYTINIL 1134
Query: 1020 YDGHPVPGSPYTVEASLPPDPSKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTV-- 1077
+ +PGSP+ DPSKV+A GPGLE G VG+ A FT+D AG L + +
Sbjct: 1135 FAEAHIPGSPFKATIRPVFDPSKVRASGPGLERGKVGEAATFTVDCSEAGEAELTIEILS 1194
Query: 1078 EGPCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVV 1137
+ +A++ +N DGT ++Y P PG Y + I + +P P + ++ D S V
Sbjct: 1195 DAGVKAEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHVQPAVDTSGVK 1254
Query: 1138 ASGPGLE-HGKVGEAGL-LSVDC---SEAGPGALGLEAVSDSGTKAEVSIQNNKDGTYAV 1192
SGPG+E HG + E +VD + G + ++ SG K + + +N DGTY V
Sbjct: 1255 VSGPGVEPHGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRV 1314
Query: 1193 TYVPLTAGMYTLTMKYGGELVPHFPARVKVEPAVDTSRIKVFGPGIEGKDVFREATTDFT 1252
Y G++ + + Y VP P RV V D +R++ FGPG+EG V + FT
Sbjct: 1315 QYTAYEEGVHLVEVLYDEVAVPKSPFRVGVTEGCDPTRVRAFGPGLEGGLVNK--ANRFT 1372
Query: 1253 VDSRPLTQVGGDHIKAHIANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVP 1312
V++R G + I PS A C DN DG+ VEY PF G + V +T+ P
Sbjct: 1373 VETRG---AGTGGLGLAIEGPSEAKMSC--KDNKDGSCTVEYIPFTPGDYDVNITFGGRP 1427
Query: 1313 IPNSPFKVAVTEGCQPSRVQAQGPGLKEAFTNK-PNVFTVVTRGAGIGGLGITVEGPS-- 1369
IP SPF+V V + P +V+ GPGL + P FTV AG L + V GP+
Sbjct: 1428 IPGSPFRVPVKDVVDPGKVKCSGPGLGAGVRARVPQTFTVDCSQAGRAPLQVAVLGPTGV 1487
Query: 1370 ESKINCRDNKDGSCSAEYIPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVDPSKVKIAGP 1429
+ RDN DG+ + Y P G Y V + Y +P SPF++ V D SKV+ +GP
Sbjct: 1488 AEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVLPAHDASKVRASGP 1547
Query: 1430 GLG-SGVRARVLQSFTVDSSKAGLAPLEVRVLGPRGLVEPVNVVDNGDGTHTVTYTPSQE 1488
GL SG+ A + FT+D+ AG L V++L P G + N+ DNGDGT+TV+Y P
Sbjct: 1548 GLNASGIPASLPVEFTIDARDAGEGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDMS 1607
Query: 1489 GPYMVSVKYADEEIPRSPFKVKVLPTYDASK----VTASGPGLSSYGVPA---SLPVDFA 1541
G Y +++KY +EIP SPF++ LPT DASK V+ G GL + P
Sbjct: 1608 GRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLGPRIQIGQETVIT 1667
Query: 1542 IDARDAGEGLLAVQITDQEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGVTYGGDDIPL 1601
+DA+ AGEG + ++ +G V +N DGT+ + Y + G+Y+I + +GG+ IP
Sbjct: 1668 VDAKAAGEGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGEHIPN 1727
Query: 1602 SPYRIRA----------TQTGDASKCLATG-PGIASTVKTGEEVGFVVDAKTA------- 1643
SP+ + A ++ + A PG T EE V+ +
Sbjct: 1728 SPFHVLACDPLPHEEEPSEVPQLRQPYAPPRPGARPTHWATEEPVVPVEPMESMLRPFNL 1787
Query: 1644 ------GKGKVTCTVLTPDGTEAEADVIENEDGTYDIFYTAAKPGTYVIYVRFGGVDIPN 1697
KG++T V P G A ++ +N+DGT + Y + G + + +++ G IP
Sbjct: 1788 VIPFAVQKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPG 1847
Query: 1698 SPFTVMATDGEVTAVEEAPVNACPPGFRPWVTEEAYVPVSDMNGLGFKPFDL-VIPFAVR 1756
SP V A+ V+A PG +G+ KP ++
Sbjct: 1848 SPLQFY-----VDAINSRHVSAYGPGLS--------------HGMVNKPATFTIVTKDAG 1888
Query: 1757 KGEITGEVHMPSGKTATPEIVDNKDGTVTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYV 1816
+G ++ V PS T + DNKDGT TV Y PT G + + +++ HIP SP +
Sbjct: 1889 EGGLSLAVEGPSKAEITCK--DNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKI 1946
Query: 1817 NYPNSGSVSAYGPGLVYGVANKTATFTIVTEDAGEGGLDLAIEGPSKAEISCIDNK--DG 1874
+S S G V+ K I D + L +I PS E C+ + +
Sbjct: 1947 TGDDSMRTSQLNVGTSTDVSLK-----ITESDLSQ--LTASIRAPSGNEEPCLLKRLPNR 1999
Query: 1875 TCTVTYLPTLPGDYSILVKYNDKHIPGSPF-----------TAKITDDSRRCSQVKLGSA 1923
+++ P G++ + V+ + KH+ SPF +K+ + S+
Sbjct: 2000 HIGISFTPKEVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGHTFQV 2059
Query: 1924 ADFLLDISETDLSSLTASIKAPSGRDEPCLLKRLPNNHIGISFIPREVGEHLVSIKKNGN 1983
A+F++D L SI+ PS D C + + + +++ P E G ++++IK
Sbjct: 2060 AEFIVDTRNAGYGGLGLSIEGPSKVDINC--EDMEDGTCKVTYCPTEPGTYIINIKFADK 2117
Query: 1984 HVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFEMSDFIVDTRDAGYGGISLAVEGPS 2043
HV SP ++ V EGR M + I R A S+A G S
Sbjct: 2118 HVPGSPFTVKVT-----------------GEGR---MKESITRRRQAP----SIATIG-S 2152
Query: 2044 KVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFA-DEHVPGSPFTVKISG--------EGR 2094
D+ + ++F V ++ F H +IS E R
Sbjct: 2153 TCDLNLK------IPGNWFQMVSAQERLTRTFTRSSHTYTRTERTEISKTRGGETKREVR 2206
Query: 2095 VKESITRTSRAPSVATVGSICD----------LNLKIPEINSSDMSAHVTSPSGRVTEAE 2144
V+ES T+ P A G + E +S DM+A VTSPSG+V AE
Sbjct: 2207 VEES-TQVGGDPFPAVFGDFLGRERLGSFGSITRQQEGEASSQDMTAQVTSPSGKVEAAE 2265
Query: 2145 IVPMGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGPGLE 2204
IV +++ VRFVPQEMG HTV+VKYRGQHV GSPFQFTVGPLGEGGAHKVRAGG GLE
Sbjct: 2266 IVEGEDSAYSVRFVPQEMGPHTVAVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLE 2325
Query: 2205 RGEAGVPAEFSIWTREAGAGGLSIAVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYEVSI 2264
RG AGVPAEFSIWTREAGAGGLSIAVEGPSKAEI F+D K+GSCGVSY+ QEPG+YEVSI
Sbjct: 2326 RGVAGVPAEFSIWTREAGAGGLSIAVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSI 2385
Query: 2265 KFNDEHIPESPYLVPVIAPSDDARRLTVMSLQESGLKVNQPASFAIRLNGAKGKIDAKVH 2324
KFNDEHIP+SP++VPV + SDDARRLTV SLQE+GLKVNQPASFA++LNGA+G IDA+VH
Sbjct: 2386 KFNDEHIPDSPFVVPVASLSDDARRLTVTSLQETGLKVNQPASFAVQLNGARGVIDARVH 2445
Query: 2325 SPSGAVEECHVSELEPDKYAVRFIPHENGVHTIDVKFNGSHVVGSPFKVRVGEPGQAGNP 2384
+PSGAVEEC+VSEL+ DK+ +RFIPHENGVH+IDVKFNG+H+ GSPFK+RVGE QAG+P
Sbjct: 2446 TPSGAVEECYVSELDSDKHTIRFIPHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDP 2505
Query: 2385 ALVSAYGTGLEGGTTGIQSEFFINTTRAGPGTLSVTIEGPSKVKMDCQETPEGYKVMYTP 2444
LVSAYG GLEGGTTG+ SEF +NT AG G LSVTI+GPSKV++DC+E PEG+ V YTP
Sbjct: 2506 GLVSAYGPGLEGGTTGVSSEFIVNTLNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTP 2565
Query: 2445 MAPGNYLISVKYGGPNHIVGSPFKAKVTGQRLVSPGSANETSSILVESVTRSSTE--TCY 2502
MAPGNYLI++KYGGP HIVGSPFKAKVTG RL S +ETS++LVE+VT+SS+ + Y
Sbjct: 2566 MAPGNYLIAIKYGGPQHIVGSPFKAKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSY 2625
Query: 2503 SAIPKASSDASKVTSKGAGLSKAFVGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSMK 2562
S+IPK SSDASKV ++G GLS+AFVGQK+SF VDCSKAG+NM+++GVHGP TPCEEV +K
Sbjct: 2626 SSIPKFSSDASKVVTRGPGLSQAFVGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVK 2685
Query: 2563 HVGNQQYNVTYVVKERGDYVLAVKWGEEHIPGSPFHVTVP 2602
H+GN+ YNVTY VKE+GDY+L VKWG+E +PGSPF V VP
Sbjct: 2686 HMGNRVYNVTYTVKEKGDYILIVKWGDESVPGSPFKVKVP 2725
Score = 140 bits (352), Expect = 2e-32
Identities = 126/438 (28%), Positives = 195/438 (44%), Gaps = 64/438 (14%)
Query: 244 PGAPLKPKLNP------KKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPE 297
PG+P + + P K RA G G+E + PA+F++ T AG G + + VE P
Sbjct: 2298 PGSPFQFTVGPLGEGGAHKVRAGGTGLER--GVAGVPAEFSIWTREAGAGGLSIAVEGP- 2354
Query: 298 GNKEEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVSVDKAQGDASKV 357
+A++ + K+ + V Y+ + G ++V++ F +HI SPF V V DA ++
Sbjct: 2355 ---SKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDARRL 2411
Query: 358 TAKGPGLEAVGNIANKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDKGNQVYRCV 417
T L+ G N+P F + GA G I V P G E V + + +
Sbjct: 2412 TV--TSLQETGLKVNQPASFAVQLNGAR-GVIDARVHTPSGA-VEECYVSELDSDKHTIR 2467
Query: 418 YKPMQPGPHVVKIFFAGDTIPKSPFVVQVGE---ACNPNACRASGRGLQPKGVRIRETTD 474
+ P + G H + + F G IP SPF ++VGE A +P A G GL+ G +++
Sbjct: 2468 FIPHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLE--GGTTGVSSE 2525
Query: 475 FKVDTKAAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITWGG-HH 533
F V+T AGSG L VT+ GP ++ + ++ +G + Y P PG Y IAI +GG H
Sbjct: 2526 FIVNTLNAGSGALSVTIDGPSKVQ--LDCRECPEG-HVVTYTPMAPGNYLIAIKYGGPQH 2582
Query: 534 IPKSPFEVQV-GP------------------------------------EAGMQKVRAWG 556
I SPF+ +V GP + KV G
Sbjct: 2583 IVGSPFKAKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRG 2642
Query: 557 PGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYNDQNDGS--CDVKYWPKEPG 614
PGL VG+ F V+ + + + GP E ++ G+ +V Y KE G
Sbjct: 2643 PGLSQAFVGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKG 2702
Query: 615 EYAVHIMCDDEDIKDSPY 632
+Y + + DE + SP+
Sbjct: 2703 DYILIVKWGDESVPGSPF 2720
Score = 75.1 bits (183), Expect = 8e-13
Identities = 62/247 (25%), Positives = 105/247 (42%), Gaps = 54/247 (21%)
Query: 244 PGAPLKPKL-------NPKKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDP 296
PG+P K ++ +P AYG G+E G ++F V+T++AG G + V ++ P
Sbjct: 2488 PGSPFKIRVGEQSQAGDPGLVSAYGPGLE--GGTTGVSSEFIVNTLNAGSGALSVTIDGP 2545
Query: 297 EGNKEEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAG-QHISKSPFEV---------- 345
+ + + P+ + V Y P G + + + + G QHI SPF+
Sbjct: 2546 SKVQLDCRECPEG-----HVVTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKVTGPRLSGG 2600
Query: 346 --------------------------SVDKAQGDASKVTAKGPGLEAVGNIANKPTYFDI 379
S+ K DASKV +GPGL + F +
Sbjct: 2601 HSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQA--FVGQKNSFTV 2658
Query: 380 YTAGAGVGDIGVEVEDPQGKNTVELLVEDKGNQVYRCVYKPMQPGPHVVKIFFAGDTIPK 439
+ AG + V V P+ E+ V+ GN+VY Y + G +++ + + +++P
Sbjct: 2659 DCSKAGTNMMMVGVHGPKTP-CEEVYVKHMGNRVYNVTYTVKEKGDYILIVKWGDESVPG 2717
Query: 440 SPFVVQV 446
SPF V+V
Sbjct: 2718 SPFKVKV 2724
>gi|188595687 gamma filamin isoform b [Homo sapiens]
Length = 2692
Score = 3190 bits (8272), Expect = 0.0
Identities = 1611/2637 (61%), Positives = 1947/2637 (73%), Gaps = 134/2637 (5%)
Query: 1 MPVTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQK 60
MP TEKDLAEDAPWKKIQQNTFTRWCNEHLKCV KR+ +LQ DLSDGLRLIALLEVLSQK
Sbjct: 21 MPSTEKDLAEDAPWKKIQQNTFTRWCNEHLKCVGKRLTDLQRDLSDGLRLIALLEVLSQK 80
Query: 61 RMYRKYHQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILH 120
RMYRK+H RP FRQM+LENVSVALEFL+RE IKLVSIDSKAIVDGNLKLILGL+WTLILH
Sbjct: 81 RMYRKFHPRPNFRQMKLENVSVALEFLEREHIKLVSIDSKAIVDGNLKLILGLIWTLILH 140
Query: 121 YSISMPVWEDEGDDDAKKQTPKQRLLGWIQNKIPYLPITNFNQNWQDGKALGALVDSCAP 180
YSISMP+WEDE D+DA+KQTPKQRLLGWIQNK+P LPITNFN++WQDGKALGALVD+CAP
Sbjct: 141 YSISMPMWEDEDDEDARKQTPKQRLLGWIQNKVPQLPITNFNRDWQDGKALGALVDNCAP 200
Query: 181 GLCPDWESWDPQKPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLSQFPKA 240
GLCPDWE+WDP +PV+NAREAMQQADDWLGVPQVI PEEI+ P+VDEHSVMTYLSQFPKA
Sbjct: 201 GLCPDWEAWDPNQPVENAREAMQQADDWLGVPQVIAPEEIVDPNVDEHSVMTYLSQFPKA 260
Query: 241 KLKPGAPLKPK-LNPKKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGN 299
KLKPGAP++ K LNPKKA AYG GIEP GN V QPA FTV T+ AG G+V+V++EDPEG+
Sbjct: 261 KLKPGAPVRSKQLNPKKAIAYGPGIEPQGNTVLQPAHFTVQTVDAGVGEVLVYIEDPEGH 320
Query: 300 KEEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVSVDKAQGDASKVTA 359
EEA+V P++DK++TY+V Y+PKV GLHKVTVLFAGQ+I +SPFEV+V A GDA+KV+A
Sbjct: 321 TEEAKVVPNNDKDRTYAVSYVPKVAGLHKVTVLFAGQNIERSPFEVNVGMALGDANKVSA 380
Query: 360 KGPGLEAVGNIANKPTYFDIYTAGAGVGDIGVEVEDPQGK-NTVELLVEDKGNQVYRCVY 418
+GPGLE VGN+ANKPTYFDIYTAGAG GD+ V + DPQG+ +TVE+ +EDKG+ +RC Y
Sbjct: 381 RGPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDSTFRCTY 440
Query: 419 KPMQPGPHVVKIFFAGDTIPKSPFVVQVGEACNPNACRASGRGLQPKGVRIRETTDFKVD 478
+P GPH V + FAG I +SPF V V EACNPNACRASGRGLQPKGVR++E DFKV
Sbjct: 441 RPAMEGPHTVHVAFAGAPITRSPFPVHVSEACNPNACRASGRGLQPKGVRVKEVADFKVF 500
Query: 479 TKAAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITWGGHHIPKSP 538
TK AGSGEL VT+KGPKG EE VK ++ DGV+ EYYP PG+Y + ITWGG+ IP+SP
Sbjct: 501 TKGAGSGELKVTVKGPKGTEEPVKVREAGDGVFECEYYPVVPGKYVVTITWGGYAIPRSP 560
Query: 539 FEVQVGPEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYND 598
FEVQV PEAG+QKVRAWGPGL G VG+SADFVVE+IG+EVG+LGF+IEGPSQAKIE +D
Sbjct: 561 FEVQVSPEAGVQKVRAWGPGLETGQVGKSADFVVEAIGTEVGTLGFSIEGPSQAKIECDD 620
Query: 599 QNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGYNPDLVRAYGPGLEKS 658
+ DGSCDV+YWP EPGEYAVH++CDDEDI+DSP++A I PA PD V+A+GPGLE +
Sbjct: 621 KGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHILPAPPDCFPDKVKAFGPGLEPT 680
Query: 659 GCIVNNLAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGTYACSYTPVKAIKHTI 718
GCIV+ AEFT+D + AGK LK++AQD +G IDI++ DGT+ CSY P K IKHTI
Sbjct: 681 GCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSYVPTKPIKHTI 740
Query: 719 AVVWGGVNIPHSPYRVNIGQGSHPQKVKVFGPGVERSGLKANEPTHFTVDCTEAGEGDVS 778
+ WGGVN+P SP+RVN+G+GSHP++VKV+GPGVE++GLKANEPT+FTVDC+EAG+GDVS
Sbjct: 741 IISWGGVNVPKSPFRVNVGEGSHPERVKVYGPGVEKTGLKANEPTYFTVDCSEAGQGDVS 800
Query: 779 VGIKCDARVLSEDEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPASPFRVK 838
+GIKC V+ E D+DFDII N NDTFTVKY PP AGRYTI VLFA+QEIPASPF +K
Sbjct: 801 IGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLFANQEIPASPFHIK 860
Query: 839 VDPSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFNSPLPGDAVKDLDI 898
VDPSHDASKVKAEGPGL++ GVE GKPTHFTV TKGAGKA L+VQF G+ V+D +I
Sbjct: 861 VDPSHDASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVQFAGTAKGEVVRDFEI 920
Query: 899 IDNYDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTVGVAAPLDLSKIKLNGLENRVEV 958
IDN+DYS+TVKYT QQGNM V VTYGGDP+PKSPF V VA PLDLSKIK+ GL ++V V
Sbjct: 921 IDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPPLDLSKIKVQGLNSKVAV 980
Query: 959 GKDQEFTVDTRGAGGQGKLDVTILSPSRKVVPCLVTPVTGRENSTAKFIPREEGLYAVDV 1018
G++Q F+V+TRGAGGQG+LDV + SPSR+ +PC + P G E +++P EEG Y VD+
Sbjct: 981 GQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGGGAEAQAVRYMPPEEGPYKVDI 1040
Query: 1019 TYDGHPVPGSPYTVEASLPPDPSKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTVE 1078
TYDGHPVPGSP+ VE LPPDPSKV A+GPGL+GGLVG PA F+IDTKGAGTGGLGLTVE
Sbjct: 1041 TYDGHPVPGSPFAVEGVLPPDPSKVCAYGPGLKGGLVGTPAPFSIDTKGAGTGGLGLTVE 1100
Query: 1079 GPCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVVA 1138
GPCEAKIEC DNGDG+C+VSYLPT+PGEY +NILF E HIPGSPFKA I FDPSKV A
Sbjct: 1101 GPCEAKIECQDNGDGSCAVSYLPTEPGEYTINILFAEAHIPGSPFKATIRPVFDPSKVRA 1160
Query: 1139 SGPGLEHGKVGEAGLLSVDCSEAGPGALGLEAVSDSGTKAEVSIQNNKDGTYAVTYVPLT 1198
SGPGLE GKVGEA +VDCSEAG L +E +SD+G KAEV I NN DGTY +TY P
Sbjct: 1161 SGPGLERGKVGEAATFTVDCSEAGEAELTIEILSDAGVKAEVLIHNNADGTYHITYSPAF 1220
Query: 1199 AGMYTLTMKYGGELVPHFPARVKVEPAVDTSRIKVFGPGIEGKDVFREATTDFTVDSRPL 1258
G YT+T+KYGG VP FP RV V+PAVDTS +KV GPG+E V RE TT+FTVD+R L
Sbjct: 1221 PGTYTITIKYGGHPVPKFPTRVHVQPAVDTSGVKVSGPGVEPHGVLREVTTEFTVDARSL 1280
Query: 1259 TQVGGDHIKAHIANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVPIPNSPF 1318
T GG+H+ A + NPSGA T+ +VTDN DGTY+V+YT +E+G+H+VEV YD+V +P SPF
Sbjct: 1281 TATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRVQYTAYEEGVHLVEVLYDEVAVPKSPF 1340
Query: 1319 KVAVTEGCQPSRVQAQGPGLKEAFTNKPNVFTVVTRGAGIGGLGITVEGPSESKINCRDN 1378
+V VTEGC P+RV+A GPGL+ NK N FTV TRGAG GGLG+ +EGPSE+K++C+DN
Sbjct: 1341 RVGVTEGCDPTRVRAFGPGLEGGLVNKANRFTVETRGAGTGGLGLAIEGPSEAKMSCKDN 1400
Query: 1379 KDGSCSAEYIPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVDPSKVKIAGPGLGSGVRAR 1438
KDGSC+ EYIPF PGDYDVNIT+GG IPGSPFRVPVKDVVDP KVK +GPGLG+GVRAR
Sbjct: 1401 KDGSCTVEYIPFTPGDYDVNITFGGRPIPGSPFRVPVKDVVDPGKVKCSGPGLGAGVRAR 1460
Query: 1439 VLQSFTVDSSKAGLAPLEVRVLGPRGLVEPVNVVDNGDGTHTVTYTPSQEGPYMVSVKYA 1498
V Q+FTVD S+AG APL+V VLGP G+ EPV V DNGDGTHTV YTP+ +GPY V+VKYA
Sbjct: 1461 VPQTFTVDCSQAGRAPLQVAVLGPTGVAEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYA 1520
Query: 1499 DEEIPRSPFKVKVLPTYDASKVTASGPGLSSYGVPASLPVDFAIDARDAGEGLLAVQITD 1558
D+E+PRSPFK+KVLP +DASKV ASGPGL++ G+PASLPV+F IDARDAGEGLL VQI D
Sbjct: 1521 DQEVPRSPFKIKVLPAHDASKVRASGPGLNASGIPASLPVEFTIDARDAGEGLLTVQILD 1580
Query: 1559 QEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGVTYGGDDIPLSPYRIRATQTGDASKCL 1618
EGKPK+A + DN DGTY V+Y+PD +GRY I + YGGD+IP SP+RI A TGDASKCL
Sbjct: 1581 PEGKPKKANIRDNGDGTYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHALPTGDASKCL 1640
Query: 1619 AT--------GPGIASTVKTGEEVGFVVDAKTAGKGKVTCTVLTPDGTEAEADVIENEDG 1670
T G + ++ G+E VDAK AG+GKVTCTV TPDG E + DV+EN DG
Sbjct: 1641 VTVSIGGHGLGACLGPRIQIGQETVITVDAKAAGEGKVTCTVSTPDGAELDVDVVENHDG 1700
Query: 1671 TYDIFYTAAKPGTYVIYVRFGGVDIPNSPFTVMATDGEVTAVEEAPVNACPPGFRPWVTE 1730
T+DI+YTA +PG YVI +RFGG IPNSPF V+A TE
Sbjct: 1701 TFDIYYTAPEPGKYVITIRFGGEHIPNSPFHVLA------------------------TE 1736
Query: 1731 EAYVPVSDMNGLGFKPFDLVIPFAVRKGEITGEVHMPSGKTATPEIVDNKDGTVTVRYAP 1790
E VPV M + +PF+LVIPFAV+KGE+TGEV MPSGKTA P I DNKDGT+TVRYAP
Sbjct: 1737 EPVVPVEPMESM-LRPFNLVIPFAVQKGELTGEVRMPSGKTARPNITDNKDGTITVRYAP 1795
Query: 1791 TEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVSAYGPGLVYGVANKTATFTIVTEDAG 1850
TE GLH+M IKY G+HIP SPLQFYV+ NS VSAYGPGL +G+ NK ATFTIVT+DAG
Sbjct: 1796 TEKGLHQMGIKYDGNHIPGSPLQFYVDAINSRHVSAYGPGLSHGMVNKPATFTIVTKDAG 1855
Query: 1851 EGGLDLAIEGPSKAEISCIDNKDGTCTVTYLPTLPGDYSILVKYNDKHIPGSPFTAKIT- 1909
EGGL LA+EGPSKAEI+C DNKDGTCTV+YLPT PGDYSI+V+++DKHIPGSPFTAKIT
Sbjct: 1856 EGGLSLAVEGPSKAEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKITG 1915
Query: 1910 DDSRRCSQVKLGSAADFLLDISETDLSSLTASIKAPSGRDEPCLLKRLPNNHIGISFIPR 1969
DDS R SQ+ +G++ D L I+E+DLS LTASI+APSG +EPCLLKRLPN HIGISF P+
Sbjct: 1916 DDSMRTSQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISFTPK 1975
Query: 1970 EVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKVYGRGLSEGRTFEMSDFIVDTRD 2029
EVGEH+VS++K+G HV NSP I+V SEIGDA + +V+G+GLSEG TF++++FIVDTR+
Sbjct: 1976 EVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEGHTFQVAEFIVDTRN 2035
Query: 2030 AGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPGVYIVSTKFADEHVPGSPFTVKI 2089
AGYGG+ L++EGPSKVDI ED+EDGTCKV+Y PT PG YI++ KFAD+HVPGSPFTVK+
Sbjct: 2036 AGYGGLGLSIEGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKV 2095
Query: 2090 SGEGRVKESITRTSRAPSVATVGSICDLNLKIP-----EINSSDMSAHVTSPSGRV---T 2141
+GEGR+KESITR +APS+AT+GS CDLNLKIP +++ + + S T
Sbjct: 2096 TGEGRMKESITRRRQAPSIATIGSTCDLNLKIPGNWFQMVSAQERLTRTFTRSSHTYTRT 2155
Query: 2142 EAEIVPMGKNSHCVRFVPQEMGVHTVSVKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGP 2201
E + + R V E V G PF G + R G
Sbjct: 2156 ERTEISKTRGGETKREVRVE----------ESTQVGGDPFPAVFGDF----LGRERLGSF 2201
Query: 2202 G-LERGEAGVPAEFSIWTREAGAGGLSIAVEGPS----KAEITFDDHKNGSCGVSYIAQE 2256
G + R + G EA + ++ V PS AEI + ++ + V ++ QE
Sbjct: 2202 GSITRQQEG----------EASSQDMTAQVTSPSGKVEAAEIV--EGEDSAYSVRFVPQE 2249
Query: 2257 PGNYEVSIKFNDEHIPESPYLVPVIAPSDDARRLTVMSLQESGLK---VNQPASFAIRLN 2313
G + V++K+ +H+P SP+ + P + V + +GL+ PA F+I
Sbjct: 2250 MGPHTVAVKYRGQHVPGSPFQF-TVGPLGEGGAHKVRA-GGTGLERGVAGVPAEFSIWTR 2307
Query: 2314 GA-KGKIDAKVHSPSGAVEECHVSELEPDKYAVRFIPHENGVHTIDVKFNGSHVVGSPFK 2372
A G + V PS A E + + V ++ E G + + +KFN H+ SPF
Sbjct: 2308 EAGAGGLSIAVEGPSKA--EIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFV 2365
Query: 2373 VRVGE-PGQAGNPALVSAYGTGLEGGTTGIQSEFFINTTRAGPGTLSVTIEGPSKVKMDC 2431
V V A + S TGL+ Q F G + + PS +C
Sbjct: 2366 VPVASLSDDARRLTVTSLQETGLKVN----QPASFAVQLNGARGVIDARVHTPSGAVEEC 2421
Query: 2432 ---QETPEGYKVMYTPMAPGNYLISVKYGGPNHIVGSPFKAKVTGQRLVSPGSANETSSI 2488
+ + + + + P G + I VK+ G HI GSPFK +V Q
Sbjct: 2422 YVSELDSDKHTIRFIPHENGVHSIDVKFNGA-HIPGSPFKIRVGEQ-------------- 2466
Query: 2489 LVESVTRSSTETCYSAIPKASSDASKVTSKGAGLSKAFVGQKSSFLVDCSKAGSNMLLIG 2548
+ D V++ G GL G S F+V+ AGS L +
Sbjct: 2467 ------------------SQAGDPGLVSAYGPGLEGGTTGVSSEFIVNTLNAGSGALSVT 2508
Query: 2549 VHGPT---TPCEEVSMKHVGNQQYNVTYVVKERGDYVLAVKW-GEEHIPGSPFHVTV 2601
+ GP+ C E HV VTY G+Y++A+K+ G +HI GSPF V
Sbjct: 2509 IDGPSKVQLDCRECPEGHV------VTYTPMAPGNYLIAIKYGGPQHIVGSPFKAKV 2559
Score = 1531 bits (3965), Expect = 0.0
Identities = 951/2416 (39%), Positives = 1330/2416 (55%), Gaps = 169/2416 (6%)
Query: 256 KARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGNKEEAQVTPDSDKNKTY 315
K A G G+EP GN+ +P F + T AG GDV V + DP+G ++ +V + + T+
Sbjct: 377 KVSARGPGLEPVGNVANKPTYFDIYTAGAGTGDVAVVIVDPQGRRDTVEVALEDKGDSTF 436
Query: 316 SVEYLPKVTGLHKVTVLFAGQHISKSPFEVSVDKAQGDASKVTAKGPGLEAVGNIANKPT 375
Y P + G H V V FAG I++SPF V V +A + + A G GL+ G +
Sbjct: 437 RCTYRPAMEGPHTVHVAFAGAPITRSPFPVHVSEAC-NPNACRASGRGLQPKGVRVKEVA 495
Query: 376 YFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDKGNQVYRCVYKPMQPGPHVVKIFFAGD 435
F ++T GAG G++ V V+ P+G + V + G+ V+ C Y P+ PG +VV I + G
Sbjct: 496 DFKVFTKGAGSGELKVTVKGPKGTEE-PVKVREAGDGVFECEYYPVVPGKYVVTITWGGY 554
Query: 436 TIPKSPFVVQVGEACNPNACRASGRGLQPKGVRIRETTDFKVDTKAAGSGELGVTMKGPK 495
IP+SPF VQV RA G GL+ ++ ++ DF V+ G LG +++GP
Sbjct: 555 AIPRSPFEVQVSPEAGVQKVRAWGPGLETG--QVGKSADFVVEAIGTEVGTLGFSIEGPS 612
Query: 496 GLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITWGGHHIPKSPFEVQV---GPEAGMQKV 552
+ ++ D DG Y+P+ PG Y++ + I SPF + P+ KV
Sbjct: 613 --QAKIECDDKGDGSCDVRYWPTEPGEYAVHVICDDEDIRDSPFIAHILPAPPDCFPDKV 670
Query: 553 RAWGPGLH--GGIVGRSADFVVESIGSEVGSLGFAIEGPSQAKIEYN--DQNDGSCDVKY 608
+A+GPGL G IV + A+F +++ + G L + I+ DG+ Y
Sbjct: 671 KAFGPGLEPTGCIVDKPAEFTIDARAAGKGDLKLYAQDADGCPIDIKVIPNGDGTFRCSY 730
Query: 609 WPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGYNPDLVRAYGPGLEKSGCIVNNLAEF 668
P +P ++ + I ++ SP+ + G +P+ V+ YGPG+EK+G N F
Sbjct: 731 VPTKPIKHTIIISWGGVNVPKSPFRVNVGE---GSHPERVKVYGPGVEKTGLKANEPTYF 787
Query: 669 TVDPKDAGKAPLKIFAQDGEG------QRIDIQMKNRMDGTYACSYTPVKAIKHTIAVVW 722
TVD +AG+ + I + G ID + + T+ YTP A ++TI V++
Sbjct: 788 TVDCSEAGQGDVSIGIKCAPGVVGPAEADIDFDIIKNDNDTFTVKYTPPGAGRYTIMVLF 847
Query: 723 GGVNIPHSPYRVNIGQGSHPQKVKVFGPGVERSGLKANEPTHFTVDCTEAGEGDVSVGIK 782
IP SP+ + + KVK GPG+ R+G++ +PTHFTV AG+ + V
Sbjct: 848 ANQEIPASPFHIKVDPSHDASKVKAEGPGLNRTGVEVGKPTHFTVLTKGAGKAKLDVQFA 907
Query: 783 CDARVLSEDEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQEIPASPFRVKVDPS 842
A+ E DF+II N + ++TVKY G + V + +P SPF V V P
Sbjct: 908 GTAK----GEVVRDFEIIDNHDYSYTVKYTAVQQGNMAVTVTYGGDPVPKSPFVVNVAPP 963
Query: 843 HDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAG-KAPLNVQFNSPLPGDAVKDLDIIDN 901
D SK+K +G SK V G+ F+V T+GAG + L+V+ SP L+
Sbjct: 964 LDLSKIKVQGLN-SKVAV--GQEQAFSVNTRGAGGQGQLDVRMTSPSRRPIPCKLEPGGG 1020
Query: 902 YDYSHTVKYTPTQQGNMQVLVTYGGDPIPKSPFTVGVAAPLDLSKIKLNG--LENRVEVG 959
+ + V+Y P ++G +V +TY G P+P SPF V P D SK+ G L+ + VG
Sbjct: 1021 AE-AQAVRYMPPEEGPYKVDITYDGHPVPGSPFAVEGVLPPDPSKVCAYGPGLKGGL-VG 1078
Query: 960 KDQEFTVDTRGAGGQGKLDVTILSPSRKVVPCLVTPVTGRENSTAKFIPREEGLYAVDVT 1019
F++DT+GAG G L +T+ P + C G + ++P E G Y +++
Sbjct: 1079 TPAPFSIDTKGAG-TGGLGLTVEGPCEAKIEC---QDNGDGSCAVSYLPTEPGEYTINIL 1134
Query: 1020 YDGHPVPGSPYTVEASLPPDPSKVKAHGPGLEGGLVGKPAEFTIDTKGAGTGGLGLTV-- 1077
+ +PGSP+ DPSKV+A GPGLE G VG+ A FT+D AG L + +
Sbjct: 1135 FAEAHIPGSPFKATIRPVFDPSKVRASGPGLERGKVGEAATFTVDCSEAGEAELTIEILS 1194
Query: 1078 EGPCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKADIEMPFDPSKVV 1137
+ +A++ +N DGT ++Y P PG Y + I + +P P + ++ D S V
Sbjct: 1195 DAGVKAEVLIHNNADGTYHITYSPAFPGTYTITIKYGGHPVPKFPTRVHVQPAVDTSGVK 1254
Query: 1138 ASGPGLE-HGKVGEAGL-LSVDC---SEAGPGALGLEAVSDSGTKAEVSIQNNKDGTYAV 1192
SGPG+E HG + E +VD + G + ++ SG K + + +N DGTY V
Sbjct: 1255 VSGPGVEPHGVLREVTTEFTVDARSLTATGGNHVTARVLNPSGAKTDTYVTDNGDGTYRV 1314
Query: 1193 TYVPLTAGMYTLTMKYGGELVPHFPARVKVEPAVDTSRIKVFGPGIEGKDVFREATTDFT 1252
Y G++ + + Y VP P RV V D +R++ FGPG+EG V + FT
Sbjct: 1315 QYTAYEEGVHLVEVLYDEVAVPKSPFRVGVTEGCDPTRVRAFGPGLEGGLVNK--ANRFT 1372
Query: 1253 VDSRPLTQVGGDHIKAHIANPSGASTECFVTDNADGTYQVEYTPFEKGLHVVEVTYDDVP 1312
V++R G + I PS A C DN DG+ VEY PF G + V +T+ P
Sbjct: 1373 VETRG---AGTGGLGLAIEGPSEAKMSC--KDNKDGSCTVEYIPFTPGDYDVNITFGGRP 1427
Query: 1313 IPNSPFKVAVTEGCQPSRVQAQGPGLKEAFTNK-PNVFTVVTRGAGIGGLGITVEGPS-- 1369
IP SPF+V V + P +V+ GPGL + P FTV AG L + V GP+
Sbjct: 1428 IPGSPFRVPVKDVVDPGKVKCSGPGLGAGVRARVPQTFTVDCSQAGRAPLQVAVLGPTGV 1487
Query: 1370 ESKINCRDNKDGSCSAEYIPFAPGDYDVNITYGGAHIPGSPFRVPVKDVVDPSKVKIAGP 1429
+ RDN DG+ + Y P G Y V + Y +P SPF++ V D SKV+ +GP
Sbjct: 1488 AEPVEVRDNGDGTHTVHYTPATDGPYTVAVKYADQEVPRSPFKIKVLPAHDASKVRASGP 1547
Query: 1430 GLG-SGVRARVLQSFTVDSSKAGLAPLEVRVLGPRGLVEPVNVVDNGDGTHTVTYTPSQE 1488
GL SG+ A + FT+D+ AG L V++L P G + N+ DNGDGT+TV+Y P
Sbjct: 1548 GLNASGIPASLPVEFTIDARDAGEGLLTVQILDPEGKPKKANIRDNGDGTYTVSYLPDMS 1607
Query: 1489 GPYMVSVKYADEEIPRSPFKVKVLPTYDASK----VTASGPGLSSYGVPA---SLPVDFA 1541
G Y +++KY +EIP SPF++ LPT DASK V+ G GL + P
Sbjct: 1608 GRYTITIKYGGDEIPYSPFRIHALPTGDASKCLVTVSIGGHGLGACLGPRIQIGQETVIT 1667
Query: 1542 IDARDAGEGLLAVQITDQEGKPKRAIVHDNKDGTYAVTYIPDKTGRYMIGVTYGGDDIPL 1601
+DA+ AGEG + ++ +G V +N DGT+ + Y + G+Y+I + +GG+ IP
Sbjct: 1668 VDAKAAGEGKVTCTVSTPDGAELDVDVVENHDGTFDIYYTAPEPGKYVITIRFGGEHIPN 1727
Query: 1602 SPYRIRATQTGDASKCLATGPGIASTVKTGEEVGFVVDAKTAGKGKVTCTVLTPDGTEAE 1661
SP+ + AT+ + P + + F V KG++T V P G A
Sbjct: 1728 SPFHVLATE----EPVVPVEPMESMLRPFNLVIPFAVQ-----KGELTGEVRMPSGKTAR 1778
Query: 1662 ADVIENEDGTYDIFYTAAKPGTYVIYVRFGGVDIPNSPFTVMATDGEVTAVEEAPVNACP 1721
++ +N+DGT + Y + G + + +++ G IP SP V A+ V+A
Sbjct: 1779 PNITDNKDGTITVRYAPTEKGLHQMGIKYDGNHIPGSPLQFY-----VDAINSRHVSAYG 1833
Query: 1722 PGFRPWVTEEAYVPVSDMNGLGFKPFDL-VIPFAVRKGEITGEVHMPSGKTATPEIVDNK 1780
PG +G+ KP ++ +G ++ V PS T + DNK
Sbjct: 1834 PGLS--------------HGMVNKPATFTIVTKDAGEGGLSLAVEGPSKAEITCK--DNK 1877
Query: 1781 DGTVTVRYAPTEVGLHEMHIKYMGSHIPESPLQFYVNYPNSGSVSAYGPGLVYGVANKTA 1840
DGT TV Y PT G + + +++ HIP SP + +S S G V+ K
Sbjct: 1878 DGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKITGDDSMRTSQLNVGTSTDVSLK-- 1935
Query: 1841 TFTIVTEDAGEGGLDLAIEGPSKAEISCIDNK--DGTCTVTYLPTLPGDYSILVKYNDKH 1898
I D + L +I PS E C+ + + +++ P G++ + V+ + KH
Sbjct: 1936 ---ITESDLSQ--LTASIRAPSGNEEPCLLKRLPNRHIGISFTPKEVGEHVVSVRKSGKH 1990
Query: 1899 IPGSPF-----------TAKITDDSRRCSQVKLGSAADFLLDISETDLSSLTASIKAPSG 1947
+ SPF +K+ + S+ A+F++D L SI+ PS
Sbjct: 1991 VTNSPFKILVGPSEIGDASKVRVWGKGLSEGHTFQVAEFIVDTRNAGYGGLGLSIEGPSK 2050
Query: 1948 RDEPCLLKRLPNNHIGISFIPREVGEHLVSIKKNGNHVANSPVSIMVVQSEIGDARRAKV 2007
D C + + + +++ P E G ++++IK HV SP ++ V
Sbjct: 2051 VDINC--EDMEDGTCKVTYCPTEPGTYIINIKFADKHVPGSPFTVKVT------------ 2096
Query: 2008 YGRGLSEGRTFEMSDFIVDTRDAGYGGISLAVEGPSKVDIQTEDLEDGTCKVSYFPTVPG 2067
EGR M + I R A S+A G S D+ + ++F V
Sbjct: 2097 -----GEGR---MKESITRRRQAP----SIATIG-STCDLNLK------IPGNWFQMVSA 2137
Query: 2068 VYIVSTKFA-DEHVPGSPFTVKISG--------EGRVKESITRTSRAPSVATVGSICD-- 2116
++ F H +IS E RV+ES T+ P A G
Sbjct: 2138 QERLTRTFTRSSHTYTRTERTEISKTRGGETKREVRVEES-TQVGGDPFPAVFGDFLGRE 2196
Query: 2117 --------LNLKIPEINSSDMSAHVTSPSGRVTEAEIVPMGKNSHCVRFVPQEMGVHTVS 2168
+ E +S DM+A VTSPSG+V AEIV +++ VRFVPQEMG HTV+
Sbjct: 2197 RLGSFGSITRQQEGEASSQDMTAQVTSPSGKVEAAEIVEGEDSAYSVRFVPQEMGPHTVA 2256
Query: 2169 VKYRGQHVTGSPFQFTVGPLGEGGAHKVRAGGPGLERGEAGVPAEFSIWTREAGAGGLSI 2228
VKYRGQHV GSPFQFTVGPLGEGGAHKVRAGG GLERG AGVPAEFSIWTREAGAGGLSI
Sbjct: 2257 VKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWTREAGAGGLSI 2316
Query: 2229 AVEGPSKAEITFDDHKNGSCGVSYIAQEPGNYEVSIKFNDEHIPESPYLVPVIAPSDDAR 2288
AVEGPSKAEI F+D K+GSCGVSY+ QEPG+YEVSIKFNDEHIP+SP++VPV + SDDAR
Sbjct: 2317 AVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVVPVASLSDDAR 2376
Query: 2289 RLTVMSLQESGLKVNQPASFAIRLNGAKGKIDAKVHSPSGAVEECHVSELEPDKYAVRFI 2348
RLTV SLQE+GLKVNQPASFA++LNGA+G IDA+VH+PSGAVEEC+VSEL+ DK+ +RFI
Sbjct: 2377 RLTVTSLQETGLKVNQPASFAVQLNGARGVIDARVHTPSGAVEECYVSELDSDKHTIRFI 2436
Query: 2349 PHENGVHTIDVKFNGSHVVGSPFKVRVGEPGQAGNPALVSAYGTGLEGGTTGIQSEFFIN 2408
PHENGVH+IDVKFNG+H+ GSPFK+RVGE QAG+P LVSAYG GLEGGTTG+ SEF +N
Sbjct: 2437 PHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGGTTGVSSEFIVN 2496
Query: 2409 TTRAGPGTLSVTIEGPSKVKMDCQETPEGYKVMYTPMAPGNYLISVKYGGPNHIVGSPFK 2468
T AG G LSVTI+GPSKV++DC+E PEG+ V YTPMAPGNYLI++KYGGP HIVGSPFK
Sbjct: 2497 TLNAGSGALSVTIDGPSKVQLDCRECPEGHVVTYTPMAPGNYLIAIKYGGPQHIVGSPFK 2556
Query: 2469 AKVTGQRLVSPGSANETSSILVESVTRSSTE--TCYSAIPKASSDASKVTSKGAGLSKAF 2526
AKVTG RL S +ETS++LVE+VT+SS+ + YS+IPK SSDASKV ++G GLS+AF
Sbjct: 2557 AKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPKFSSDASKVVTRGPGLSQAF 2616
Query: 2527 VGQKSSFLVDCSKAGSNMLLIGVHGPTTPCEEVSMKHVGNQQYNVTYVVKERGDYVLAVK 2586
VGQK+SF VDCSKAG+NM+++GVHGP TPCEEV +KH+GN+ YNVTY VKE+GDY+L VK
Sbjct: 2617 VGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNRVYNVTYTVKEKGDYILIVK 2676
Query: 2587 WGEEHIPGSPFHVTVP 2602
WG+E +PGSPF V VP
Sbjct: 2677 WGDESVPGSPFKVKVP 2692
Score = 404 bits (1039), Expect = e-112
Identities = 338/1234 (27%), Positives = 535/1234 (43%), Gaps = 129/1234 (10%)
Query: 244 PGAPLKPKLNP----KKARAYGRGIEPTGNMVKQPAKFTVDTISAGQGDVMVFVEDPEGN 299
P +P K K+ P K RA G G+ +G P +FT+D AG+G + V + DPEG
Sbjct: 1525 PRSPFKIKVLPAHDASKVRASGPGLNASGIPASLPVEFTIDARDAGEGLLTVQILDPEGK 1584
Query: 300 KEEAQVTPDSDKNKTYSVEYLPKVTGLHKVTVLFAGQHISKSPFEVSVDKAQGDASK--- 356
++A + + D TY+V YLP ++G + +T+ + G I SPF + GDASK
Sbjct: 1585 PKKANIRDNGDG--TYTVSYLPDMSGRYTITIKYGGDEIPYSPFRIHA-LPTGDASKCLV 1641
Query: 357 -VTAKGPGLEAVGNIA---NKPTYFDIYTAGAGVGDIGVEVEDPQGKNTVELLVEDKGNQ 412
V+ G GL A + T + AG G + V P G +++ V + +
Sbjct: 1642 TVSIGGHGLGACLGPRIQIGQETVITVDAKAAGEGKVTCTVSTPDGAE-LDVDVVENHDG 1700
Query: 413 VYRCVYKPMQPGPHVVKIFFAGDTIPKSPF-VVQVGEACNPNACRASGRGLQPKGVRIRE 471
+ Y +PG +V+ I F G+ IP SPF V+ E P ++P +R
Sbjct: 1701 TFDIYYTAPEPGKYVITIRFGGEHIPNSPFHVLATEEPVVP---------VEPMESMLRP 1751
Query: 472 TTDFKVDTKAAGSGELGVTMKGPKGLEELVKQKDFLDGVYAFEYYPSTPGRYSIAITWGG 531
V A GEL ++ P G D DG Y P+ G + + I + G
Sbjct: 1752 FN--LVIPFAVQKGELTGEVRMPSGKTARPNITDNKDGTITVRYAPTEKGLHQMGIKYDG 1809
Query: 532 HHIPKSPFEVQVGPEAGMQKVRAWGPGLHGGIVGRSADFVVESIGSEVGSLGFAIEGPSQ 591
+HIP SP + V + V A+GPGL G+V + A F + + + G L A+EGPS+
Sbjct: 1810 NHIPGSPLQFYVDA-INSRHVSAYGPGLSHGMVNKPATFTIVTKDAGEGGLSLAVEGPSK 1868
Query: 592 AKIEYNDQNDGSCDVKYWPKEPGEYAVHIMCDDEDIKDSPYMAFIHPATGGYNPDLVRAY 651
A+I D DG+C V Y P PG+Y++ + DD+ I SP+ A I TG
Sbjct: 1869 AEITCKDNKDGTCTVSYLPTAPGDYSIIVRFDDKHIPGSPFTAKI---TGD--------- 1916
Query: 652 GPGLEKSGCIVNNLAEFTVDPKDAGKAPLKIFAQDGEGQRIDIQMKNRMDGTYACSYTPV 711
+ S V + ++ ++ + L + G +K + S+TP
Sbjct: 1917 -DSMRTSQLNVGTSTDVSLKITESDLSQLTASIRAPSGNEEPCLLKRLPNRHIGISFTPK 1975
Query: 712 KAIKHTIAVVWGGVNIPHSPYRVNIGQGS--HPQKVKVFGPGVERSGLKANEPTHFTVDC 769
+ +H ++V G ++ +SP+++ +G KV+V+G G+ + F VD
Sbjct: 1976 EVGEHVVSVRKSGKHVTNSPFKILVGPSEIGDASKVRVWGKGLSEG--HTFQVAEFIVDT 2033
Query: 770 TEAGEGDVSVGIKCDARVLSEDEEDVDFDIIHNANDTFTVKYVPPAAGRYTIKVLFASQE 829
AG G + + I E VD + + T V Y P G Y I + FA +
Sbjct: 2034 RNAGYGGLGLSI--------EGPSKVDINCEDMEDGTCKVTYCPTEPGTYIINIKFADKH 2085
Query: 830 IPASPFRVKVDPSHDASKVKAEGPGLSKAGVENGKPTHFTVYTKGAGKAPLNVQFNSPLP 889
+P SPF VKV G G K + + ++ T G+ N +P
Sbjct: 2086 VPGSPFTVKVT-----------GEGRMKESITRRRQAP-SIATIGS-----TCDLNLKIP 2128
Query: 890 GDAVKDLDIIDNYDYSHT-VKYTPTQQGNMQVLVTYGGDPIPKSPFTVGVAAPLDLSKIK 948
G+ + + + + T +T T+ ++ T GG+ + D
Sbjct: 2129 GNWFQMVSAQERLTRTFTRSSHTYTRTERTEISKTRGGETKREVRVEESTQVGGDPFPAV 2188
Query: 949 LNGLENRVEVGKDQEFTVDTRGAGGQGKLDVTILSPSRKVVPCLVTPVTGRENS-TAKFI 1007
R +G T G + + SPS KV + V G +++ + +F+
Sbjct: 2189 FGDFLGRERLGSFGSITRQQEGEASSQDMTAQVTSPSGKVEAAEI--VEGEDSAYSVRFV 2246
Query: 1008 PREEGLYAVDVTYDGHPVPGSPY--TVEASLPPDPSKVKAHGPGLEGGLVGKPAEFTIDT 1065
P+E G + V V Y G VPGSP+ TV KV+A G GLE G+ G PAEF+I T
Sbjct: 2247 PQEMGPHTVAVKYRGQHVPGSPFQFTVGPLGEGGAHKVRAGGTGLERGVAGVPAEFSIWT 2306
Query: 1066 KGAGTGGLGLTVEGPCEAKIECSDNGDGTCSVSYLPTKPGEYFVNILFEEVHIPGSPFKA 1125
+ AG GGL + VEGP +A+I D DG+C VSY+ +PG+Y V+I F + HIP SPF
Sbjct: 2307 REAGAGGLSIAVEGPSKAEIAFEDRKDGSCGVSYVVQEPGDYEVSIKFNDEHIPDSPFVV 2366
Query: 1126 DIEMPFDPSKVVASGPGLEHG-KVGEAGLLSVDCSEAGPGALGLEAVSDSGTKAEVSIQN 1184
+ D ++ + E G KV + +V + A G + + SG E +
Sbjct: 2367 PVASLSDDARRLTVTSLQETGLKVNQPASFAVQLNGA-RGVIDARVHTPSGAVEECYVSE 2425
Query: 1185 NKDGTYAVTYVPLTAGMYTLTMKYGGELVPHFPARVKV---EPAVDTSRIKVFGPGIEGK 1241
+ + ++P G++++ +K+ G +P P +++V A D + +GPG+EG
Sbjct: 2426 LDSDKHTIRFIPHENGVHSIDVKFNGAHIPGSPFKIRVGEQSQAGDPGLVSAYGPGLEGG 2485
Query: 1242 DVFREATTDFTVDSRPLTQVGGDHIKAHIANPSGASTECFVTDNADGTYQVEYTPFEKGL 1301
+++F V++ G + I PS +C + +G + V YTP G
Sbjct: 2486 TT--GVSSEFIVNT---LNAGSGALSVTIDGPSKVQLDC--RECPEG-HVVTYTPMAPGN 2537
Query: 1302 HVVEVTYDDVP-IPNSPFKVAVTE------------------------------------ 1324
+++ + Y I SPFK VT
Sbjct: 2538 YLIAIKYGGPQHIVGSPFKAKVTGPRLSGGHSLHETSTVLVETVTKSSSSRGSSYSSIPK 2597
Query: 1325 -GCQPSRVQAQGPGLKEAFTNKPNVFTVVTRGAGIGGLGITVEGPSE--SKINCRDNKDG 1381
S+V +GPGL +AF + N FTV AG + + V GP ++ + +
Sbjct: 2598 FSSDASKVVTRGPGLSQAFVGQKNSFTVDCSKAGTNMMMVGVHGPKTPCEEVYVKHMGNR 2657
Query: 1382 SCSAEYIPFAPGDYDVNITYGGAHIPGSPFRVPV 1415
+ Y GDY + + +G +PGSPF+V V
Sbjct: 2658 VYNVTYTVKEKGDYILIVKWGDESVPGSPFKVKV 2691
>gi|239755812 PREDICTED: similar to spectrin, beta, non-erythrocytic
2 [Homo sapiens]
Length = 158
Score = 218 bits (554), Expect = 8e-56
Identities = 107/120 (89%), Positives = 111/120 (92%)
Query: 62 MYRKYHQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHY 121
MY KYHQRPTFRQMQL+NVSVALEFLDR+SIKLVSIDSKA VDGNLKLILGLVWTLIL Y
Sbjct: 1 MYLKYHQRPTFRQMQLKNVSVALEFLDRDSIKLVSIDSKATVDGNLKLILGLVWTLILRY 60
Query: 122 SISMPVWEDEGDDDAKKQTPKQRLLGWIQNKIPYLPITNFNQNWQDGKALGALVDSCAPG 181
SIS PV EDEGDDDAKKQ KQRLLGWIQNK+PYLPITNF+QNWQD KAL ALVDSCAPG
Sbjct: 61 SISTPVCEDEGDDDAKKQMRKQRLLGWIQNKVPYLPITNFSQNWQDSKALRALVDSCAPG 120
>gi|4557241 actinin, alpha 3 [Homo sapiens]
Length = 901
Score = 159 bits (402), Expect = 3e-38
Identities = 89/237 (37%), Positives = 144/237 (60%), Gaps = 15/237 (6%)
Query: 5 EKDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYR 64
++DL D W+K Q+ TFT WCN HL+ +I N++ D +GL+L+ LLEV+S +R+ R
Sbjct: 34 DRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPR 93
Query: 65 KYHQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSIS 124
+ R ++ NV+ AL+F+ + +KLVSI ++ IVDGNLK+ LG++WT+IL ++I
Sbjct: 94 P--DKGKMRFHKIANVNKALDFIASKGVKLVSIGAEEIVDGNLKMTLGMIWTIILRFAIQ 151
Query: 125 MPVWEDEGDDDAKKQTPKQRLLGWIQNK-IPY--LPITNFNQNWQDGKALGALVDSCAPG 181
D ++ + K+ LL W Q K PY + + NF+ +W+DG AL AL+ P
Sbjct: 152 --------DISVEETSAKEGLLLWCQRKTAPYRNVNVQNFHTSWKDGLALCALIHRHRPD 203
Query: 182 LCPDWESWDPQKPVDNAREAMQQADDWLGVPQVITPEEIIH-PDVDEHSVMTYLSQF 237
L D+ P+ N A + A+ +L +P+++ E+I++ P DE ++MTY+S F
Sbjct: 204 LI-DYAKLRKDDPIGNLNTAFEVAEKYLDIPKMLDAEDIVNTPKPDEKAIMTYVSCF 259
>gi|4501893 actinin, alpha 2 [Homo sapiens]
Length = 894
Score = 157 bits (396), Expect = 2e-37
Identities = 88/237 (37%), Positives = 144/237 (60%), Gaps = 15/237 (6%)
Query: 5 EKDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYR 64
++DL D W+K Q+ TFT WCN HL+ +I N++ D +GL+L+ LLEV+S +R+ +
Sbjct: 27 DRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRNGLKLMLLLEVISGERLPK 86
Query: 65 KYHQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSIS 124
R R ++ NV+ AL+++ + +KLVSI ++ IVDGN+K+ LG++WT+IL ++I
Sbjct: 87 P--DRGKMRFHKIANVNKALDYIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQ 144
Query: 125 MPVWEDEGDDDAKKQTPKQRLLGWIQNK-IPY--LPITNFNQNWQDGKALGALVDSCAPG 181
D ++ + K+ LL W Q K PY + I NF+ +W+DG L AL+ P
Sbjct: 145 --------DISVEETSAKEGLLLWCQRKTAPYRNVNIQNFHTSWKDGLGLCALIHRHRPD 196
Query: 182 LCPDWESWDPQKPVDNAREAMQQADDWLGVPQVITPEEIIH-PDVDEHSVMTYLSQF 237
L D+ + P+ N AM+ A+ L +P+++ E+I++ P DE ++MTY+S F
Sbjct: 197 LI-DYSKLNKDDPIGNINLAMEIAEKHLDIPKMLDAEDIVNTPKPDERAIMTYVSCF 252
>gi|12025678 actinin, alpha 4 [Homo sapiens]
Length = 911
Score = 156 bits (395), Expect = 2e-37
Identities = 87/237 (36%), Positives = 142/237 (59%), Gaps = 15/237 (6%)
Query: 5 EKDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYR 64
++DL D W+K Q+ TFT WCN HL+ +I N+ D DGL+L+ LLEV+S +R+ +
Sbjct: 39 DRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIDEDFRDGLKLMLLLEVISGERLPK 98
Query: 65 KYHQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSIS 124
+R R ++ NV+ AL+F+ + +KLVSI ++ IVDGN K+ LG++WT+IL ++I
Sbjct: 99 P--ERGKMRVHKINNVNKALDFIASKGVKLVSIGAEEIVDGNAKMTLGMIWTIILRFAIQ 156
Query: 125 MPVWEDEGDDDAKKQTPKQRLLGWIQNK-IPY--LPITNFNQNWQDGKALGALVDSCAPG 181
D ++ + K+ LL W Q K PY + + NF+ +W+DG A AL+ P
Sbjct: 157 --------DISVEETSAKEGLLLWCQRKTAPYKNVNVQNFHISWKDGLAFNALIHRHRPE 208
Query: 182 LCPDWESWDPQKPVDNAREAMQQADDWLGVPQVITPEEIIH-PDVDEHSVMTYLSQF 237
L +++ PV N A + A+ +L +P+++ E+I++ DE ++MTY+S F
Sbjct: 209 LI-EYDKLRKDDPVTNLNNAFEVAEKYLDIPKMLDAEDIVNTARPDEKAIMTYVSSF 264
>gi|194097352 actinin, alpha 1 isoform c [Homo sapiens]
Length = 887
Score = 152 bits (385), Expect = 3e-36
Identities = 87/237 (36%), Positives = 140/237 (59%), Gaps = 15/237 (6%)
Query: 5 EKDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYR 64
++DL D W+K Q+ TFT WCN HL+ +I N++ D DGL+L+ LLEV+S +R+ +
Sbjct: 20 DRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAK 79
Query: 65 KYHQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSIS 124
+R R ++ NV+ AL+F+ + +KLVSI ++ IVDGN+K+ LG++WT+IL ++I
Sbjct: 80 P--ERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQ 137
Query: 125 MPVWEDEGDDDAKKQTPKQRLLGWIQNK-IPY--LPITNFNQNWQDGKALGALVDSCAPG 181
D ++ + K+ LL W Q K PY + I NF+ +W+DG AL+ P
Sbjct: 138 --------DISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPE 189
Query: 182 LCPDWESWDPQKPVDNAREAMQQADDWLGVPQVITPEEII-HPDVDEHSVMTYLSQF 237
L D+ P+ N A A+ +L +P+++ E+I+ DE ++MTY+S F
Sbjct: 190 LI-DYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSF 245
>gi|194097350 actinin, alpha 1 isoform a [Homo sapiens]
Length = 914
Score = 152 bits (385), Expect = 3e-36
Identities = 87/237 (36%), Positives = 140/237 (59%), Gaps = 15/237 (6%)
Query: 5 EKDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYR 64
++DL D W+K Q+ TFT WCN HL+ +I N++ D DGL+L+ LLEV+S +R+ +
Sbjct: 20 DRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAK 79
Query: 65 KYHQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSIS 124
+R R ++ NV+ AL+F+ + +KLVSI ++ IVDGN+K+ LG++WT+IL ++I
Sbjct: 80 P--ERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQ 137
Query: 125 MPVWEDEGDDDAKKQTPKQRLLGWIQNK-IPY--LPITNFNQNWQDGKALGALVDSCAPG 181
D ++ + K+ LL W Q K PY + I NF+ +W+DG AL+ P
Sbjct: 138 --------DISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPE 189
Query: 182 LCPDWESWDPQKPVDNAREAMQQADDWLGVPQVITPEEII-HPDVDEHSVMTYLSQF 237
L D+ P+ N A A+ +L +P+++ E+I+ DE ++MTY+S F
Sbjct: 190 LI-DYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSF 245
>gi|4501891 actinin, alpha 1 isoform b [Homo sapiens]
Length = 892
Score = 152 bits (385), Expect = 3e-36
Identities = 87/237 (36%), Positives = 140/237 (59%), Gaps = 15/237 (6%)
Query: 5 EKDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYR 64
++DL D W+K Q+ TFT WCN HL+ +I N++ D DGL+L+ LLEV+S +R+ +
Sbjct: 20 DRDLLLDPAWEKQQRKTFTAWCNSHLRKAGTQIENIEEDFRDGLKLMLLLEVISGERLAK 79
Query: 65 KYHQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSIS 124
+R R ++ NV+ AL+F+ + +KLVSI ++ IVDGN+K+ LG++WT+IL ++I
Sbjct: 80 P--ERGKMRVHKISNVNKALDFIASKGVKLVSIGAEEIVDGNVKMTLGMIWTIILRFAIQ 137
Query: 125 MPVWEDEGDDDAKKQTPKQRLLGWIQNK-IPY--LPITNFNQNWQDGKALGALVDSCAPG 181
D ++ + K+ LL W Q K PY + I NF+ +W+DG AL+ P
Sbjct: 138 --------DISVEETSAKEGLLLWCQRKTAPYKNVNIQNFHISWKDGLGFCALIHRHRPE 189
Query: 182 LCPDWESWDPQKPVDNAREAMQQADDWLGVPQVITPEEII-HPDVDEHSVMTYLSQF 237
L D+ P+ N A A+ +L +P+++ E+I+ DE ++MTY+S F
Sbjct: 190 LI-DYGKLRKDDPLTNLNTAFDVAEKYLDIPKMLDAEDIVGTARPDEKAIMTYVSSF 245
>gi|33188445 microfilament and actin filament cross-linker protein
isoform a [Homo sapiens]
Length = 5430
Score = 144 bits (363), Expect = 1e-33
Identities = 92/231 (39%), Positives = 131/231 (56%), Gaps = 16/231 (6%)
Query: 16 KIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYRKYHQRPTFRQM 75
++Q+ TFT+W N+HL V K I +L DL DG LI+LLEVLS ++ R ++ R
Sbjct: 78 RVQKKTFTKWVNKHLMKVRKHINDLYEDLRDGHNLISLLEVLSGIKLPR---EKGRMRFH 134
Query: 76 QLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSISMPVWEDEGDDD 135
+L+NV +AL+FL + +KLV+I + I DGN KL LGL+WT+ILH+ IS E D
Sbjct: 135 RLQNVQIALDFLKQRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIYISGESGD- 193
Query: 136 AKKQTPKQRLLGWIQN---KIPYLPITNFNQNWQDGKALGALVDSCAPGLCPDWESWDPQ 192
+ K++LL W Q + TNF+ W DGK AL+ P L D E Q
Sbjct: 194 ---MSAKEKLLLWTQKVTAGYTGIKCTNFSSCWSDGKMFNALIHRYRPDLV-DMERVQIQ 249
Query: 193 KPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLSQ----FPK 239
+N +A + A+ LGV +++ E++ P DE SV+TY+S FPK
Sbjct: 250 SNRENLEQAFEVAER-LGVTRLLDAEDVDVPSPDEKSVITYVSSIYDAFPK 299
>gi|112382250 spectrin, beta, non-erythrocytic 1 isoform 1 [Homo
sapiens]
Length = 2364
Score = 140 bits (352), Expect = 2e-32
Identities = 92/235 (39%), Positives = 134/235 (57%), Gaps = 16/235 (6%)
Query: 6 KDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYRK 65
K LA++ + +Q+ TFT+W N HL V+ RI +L TDL DG LI LLEVLS +R+
Sbjct: 46 KALADER--EAVQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERL--- 100
Query: 66 YHQRPTFRQMQ---LENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYS 122
+PT +M+ LENV AL+FL + + L ++ S IVDGN +L LGL+WT+IL +
Sbjct: 101 --PKPTKGRMRIHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQ 158
Query: 123 ISMPVWEDEGDDDAKKQTPKQRLLGWIQNK---IPYLPITNFNQNWQDGKALGALVDSCA 179
I E E D+ +K++ K LL W Q K P + I NF +W+DG A AL+
Sbjct: 159 IQDISVETE--DNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHR 216
Query: 180 PGLCPDWESWDPQKPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYL 234
P L D++ N + A A+ LG+ +++ PE+I DE S++TY+
Sbjct: 217 PDLI-DFDKLKKSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYV 270
>gi|112382252 spectrin, beta, non-erythrocytic 1 isoform 2 [Homo
sapiens]
Length = 2155
Score = 139 bits (351), Expect = 3e-32
Identities = 89/224 (39%), Positives = 128/224 (57%), Gaps = 14/224 (6%)
Query: 17 IQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYRKYHQRPTFRQMQ 76
+Q+ TFT+W N HL V+ RI +L TDL DG LI LLEVLS +R+ +PT +M+
Sbjct: 42 VQKKTFTKWVNSHLARVSCRITDLYTDLRDGRMLIKLLEVLSGERL-----PKPTKGRMR 96
Query: 77 ---LENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSISMPVWEDEGD 133
LENV AL+FL + + L ++ S IVDGN +L LGL+WT+IL + I E E
Sbjct: 97 IHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLTLGLIWTIILRFQIQDISVETE-- 154
Query: 134 DDAKKQTPKQRLLGWIQNK---IPYLPITNFNQNWQDGKALGALVDSCAPGLCPDWESWD 190
D+ +K++ K LL W Q K P + I NF +W+DG A AL+ P L D++
Sbjct: 155 DNKEKKSAKDALLLWCQMKTAGYPNVNIHNFTTSWRDGMAFNALIHKHRPDLI-DFDKLK 213
Query: 191 PQKPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYL 234
N + A A+ LG+ +++ PE+I DE S++TY+
Sbjct: 214 KSNAHYNLQNAFNLAEQHLGLTKLLDPEDISVDHPDEKSIITYV 257
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 139 bits (351), Expect = 3e-32
Identities = 82/223 (36%), Positives = 128/223 (57%), Gaps = 11/223 (4%)
Query: 16 KIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYRKYHQRPTFRQM 75
++Q+ TFT+W N+HL + I +L DL DG LI+LLEVLS + R ++ R
Sbjct: 42 RVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR---EKGRMRFH 98
Query: 76 QLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSISMPVWEDEGDDD 135
+L+NV +AL++L +KLV+I + I DGN KL LGL+WT+ILH+ IS + +
Sbjct: 99 KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQIS----DIQVSGQ 154
Query: 136 AKKQTPKQRLLGWIQNKI---PYLPITNFNQNWQDGKALGALVDSCAPGLCPDWESWDPQ 192
++ T K++LL W Q + L NF +W+DG+ A++ P L D Q
Sbjct: 155 SEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP-LLIDMNKVYRQ 213
Query: 193 KPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLS 235
++N +A A+ LGV +++ PE++ P DE S++TY+S
Sbjct: 214 TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVS 256
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 139 bits (351), Expect = 3e-32
Identities = 82/223 (36%), Positives = 128/223 (57%), Gaps = 11/223 (4%)
Query: 16 KIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYRKYHQRPTFRQM 75
++Q+ TFT+W N+HL + I +L DL DG LI+LLEVLS + R ++ R
Sbjct: 46 RVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR---EKGRMRFH 102
Query: 76 QLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSISMPVWEDEGDDD 135
+L+NV +AL++L +KLV+I + I DGN KL LGL+WT+ILH+ IS + +
Sbjct: 103 KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQIS----DIQVSGQ 158
Query: 136 AKKQTPKQRLLGWIQNKI---PYLPITNFNQNWQDGKALGALVDSCAPGLCPDWESWDPQ 192
++ T K++LL W Q + L NF +W+DG+ A++ P L D Q
Sbjct: 159 SEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP-LLIDMNKVYRQ 217
Query: 193 KPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLS 235
++N +A A+ LGV +++ PE++ P DE S++TY+S
Sbjct: 218 TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVS 260
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 139 bits (351), Expect = 3e-32
Identities = 82/223 (36%), Positives = 128/223 (57%), Gaps = 11/223 (4%)
Query: 16 KIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYRKYHQRPTFRQM 75
++Q+ TFT+W N+HL + I +L DL DG LI+LLEVLS + R ++ R
Sbjct: 42 RVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR---EKGRMRFH 98
Query: 76 QLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSISMPVWEDEGDDD 135
+L+NV +AL++L +KLV+I + I DGN KL LGL+WT+ILH+ IS + +
Sbjct: 99 KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQIS----DIQVSGQ 154
Query: 136 AKKQTPKQRLLGWIQNKI---PYLPITNFNQNWQDGKALGALVDSCAPGLCPDWESWDPQ 192
++ T K++LL W Q + L NF +W+DG+ A++ P L D Q
Sbjct: 155 SEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP-LLIDMNKVYRQ 213
Query: 193 KPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLS 235
++N +A A+ LGV +++ PE++ P DE S++TY+S
Sbjct: 214 TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVS 256
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 139 bits (351), Expect = 3e-32
Identities = 82/223 (36%), Positives = 128/223 (57%), Gaps = 11/223 (4%)
Query: 16 KIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYRKYHQRPTFRQM 75
++Q+ TFT+W N+HL + I +L DL DG LI+LLEVLS + R ++ R
Sbjct: 10 RVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR---EKGRMRFH 66
Query: 76 QLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSISMPVWEDEGDDD 135
+L+NV +AL++L +KLV+I + I DGN KL LGL+WT+ILH+ IS + +
Sbjct: 67 KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQIS----DIQVSGQ 122
Query: 136 AKKQTPKQRLLGWIQNKI---PYLPITNFNQNWQDGKALGALVDSCAPGLCPDWESWDPQ 192
++ T K++LL W Q + L NF +W+DG+ A++ P L D Q
Sbjct: 123 SEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP-LLIDMNKVYRQ 181
Query: 193 KPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLS 235
++N +A A+ LGV +++ PE++ P DE S++TY+S
Sbjct: 182 TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVS 224
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 139 bits (351), Expect = 3e-32
Identities = 82/223 (36%), Positives = 128/223 (57%), Gaps = 11/223 (4%)
Query: 16 KIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYRKYHQRPTFRQM 75
++Q+ TFT+W N+HL + I +L DL DG LI+LLEVLS + R ++ R
Sbjct: 179 RVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR---EKGRMRFH 235
Query: 76 QLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSISMPVWEDEGDDD 135
+L+NV +AL++L +KLV+I + I DGN KL LGL+WT+ILH+ IS + +
Sbjct: 236 KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQIS----DIQVSGQ 291
Query: 136 AKKQTPKQRLLGWIQNKI---PYLPITNFNQNWQDGKALGALVDSCAPGLCPDWESWDPQ 192
++ T K++LL W Q + L NF +W+DG+ A++ P L D Q
Sbjct: 292 SEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP-LLIDMNKVYRQ 350
Query: 193 KPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLS 235
++N +A A+ LGV +++ PE++ P DE S++TY+S
Sbjct: 351 TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVS 393
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 139 bits (351), Expect = 3e-32
Identities = 82/223 (36%), Positives = 128/223 (57%), Gaps = 11/223 (4%)
Query: 16 KIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYRKYHQRPTFRQM 75
++Q+ TFT+W N+HL + I +L DL DG LI+LLEVLS + R ++ R
Sbjct: 20 RVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR---EKGRMRFH 76
Query: 76 QLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSISMPVWEDEGDDD 135
+L+NV +AL++L +KLV+I + I DGN KL LGL+WT+ILH+ IS + +
Sbjct: 77 KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQIS----DIQVSGQ 132
Query: 136 AKKQTPKQRLLGWIQNKI---PYLPITNFNQNWQDGKALGALVDSCAPGLCPDWESWDPQ 192
++ T K++LL W Q + L NF +W+DG+ A++ P L D Q
Sbjct: 133 SEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP-LLIDMNKVYRQ 191
Query: 193 KPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLS 235
++N +A A+ LGV +++ PE++ P DE S++TY+S
Sbjct: 192 TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVS 234
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 139 bits (351), Expect = 3e-32
Identities = 82/223 (36%), Positives = 128/223 (57%), Gaps = 11/223 (4%)
Query: 16 KIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYRKYHQRPTFRQM 75
++Q+ TFT+W N+HL + I +L DL DG LI+LLEVLS + R ++ R
Sbjct: 28 RVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR---EKGRMRFH 84
Query: 76 QLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSISMPVWEDEGDDD 135
+L+NV +AL++L +KLV+I + I DGN KL LGL+WT+ILH+ IS + +
Sbjct: 85 KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQIS----DIQVSGQ 140
Query: 136 AKKQTPKQRLLGWIQNKI---PYLPITNFNQNWQDGKALGALVDSCAPGLCPDWESWDPQ 192
++ T K++LL W Q + L NF +W+DG+ A++ P L D Q
Sbjct: 141 SEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP-LLIDMNKVYRQ 199
Query: 193 KPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLS 235
++N +A A+ LGV +++ PE++ P DE S++TY+S
Sbjct: 200 TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVS 242
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 139 bits (351), Expect = 3e-32
Identities = 82/223 (36%), Positives = 128/223 (57%), Gaps = 11/223 (4%)
Query: 16 KIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYRKYHQRPTFRQM 75
++Q+ TFT+W N+HL + I +L DL DG LI+LLEVLS + R ++ R
Sbjct: 69 RVQKKTFTKWVNKHLIKAQRHISDLYEDLRDGHNLISLLEVLSGDSLPR---EKGRMRFH 125
Query: 76 QLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSISMPVWEDEGDDD 135
+L+NV +AL++L +KLV+I + I DGN KL LGL+WT+ILH+ IS + +
Sbjct: 126 KLQNVQIALDYLRHRQVKLVNIRNDDIADGNPKLTLGLIWTIILHFQIS----DIQVSGQ 181
Query: 136 AKKQTPKQRLLGWIQNKI---PYLPITNFNQNWQDGKALGALVDSCAPGLCPDWESWDPQ 192
++ T K++LL W Q + L NF +W+DG+ A++ P L D Q
Sbjct: 182 SEDMTAKEKLLLWSQRMVEGYQGLRCDNFTSSWRDGRLFNAIIHRHKP-LLIDMNKVYRQ 240
Query: 193 KPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLS 235
++N +A A+ LGV +++ PE++ P DE S++TY+S
Sbjct: 241 TNLENLDQAFSVAERDLGVTRLLDPEDVDVPQPDEKSIITYVS 283
>gi|221316624 dystonin isoform 4 [Homo sapiens]
Length = 5526
Score = 139 bits (350), Expect = 4e-32
Identities = 91/231 (39%), Positives = 129/231 (55%), Gaps = 16/231 (6%)
Query: 16 KIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYRKYHQRPTFRQM 75
K+Q+ TFT+W N+HL V K + +L DL DG LI+LLEVLS + R ++ R
Sbjct: 64 KVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR---EKGRMRFH 120
Query: 76 QLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSISMPVWEDEGDDD 135
+L+NV +AL++L R +KLV+I + I DGN KL LGL+WT+ILH+ IS E +D
Sbjct: 121 RLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESED- 179
Query: 136 AKKQTPKQRLLGWIQNKIP-YLPI--TNFNQNWQDGKALGALVDSCAPGLCPDWESWDPQ 192
+ K+RLL W Q Y I NF W+DGK A++ P L D + Q
Sbjct: 180 ---MSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLI-DMNTVAVQ 235
Query: 193 KPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLSQ----FPK 239
+ N A A+ +GV +++ PE++ DE SV+TY+S FPK
Sbjct: 236 SNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK 285
>gi|221316622 dystonin isoform 3 [Homo sapiens]
Length = 5537
Score = 139 bits (350), Expect = 4e-32
Identities = 91/231 (39%), Positives = 129/231 (55%), Gaps = 16/231 (6%)
Query: 16 KIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYRKYHQRPTFRQM 75
K+Q+ TFT+W N+HL V K + +L DL DG LI+LLEVLS + R ++ R
Sbjct: 75 KVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR---EKGRMRFH 131
Query: 76 QLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSISMPVWEDEGDDD 135
+L+NV +AL++L R +KLV+I + I DGN KL LGL+WT+ILH+ IS E +D
Sbjct: 132 RLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESED- 190
Query: 136 AKKQTPKQRLLGWIQNKIP-YLPI--TNFNQNWQDGKALGALVDSCAPGLCPDWESWDPQ 192
+ K+RLL W Q Y I NF W+DGK A++ P L D + Q
Sbjct: 191 ---MSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLI-DMNTVAVQ 246
Query: 193 KPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLSQ----FPK 239
+ N A A+ +GV +++ PE++ DE SV+TY+S FPK
Sbjct: 247 SNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK 296
>gi|221316618 dystonin isoform 2 [Homo sapiens]
Length = 5675
Score = 139 bits (350), Expect = 4e-32
Identities = 91/231 (39%), Positives = 129/231 (55%), Gaps = 16/231 (6%)
Query: 16 KIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYRKYHQRPTFRQM 75
K+Q+ TFT+W N+HL V K + +L DL DG LI+LLEVLS + R ++ R
Sbjct: 213 KVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR---EKGRMRFH 269
Query: 76 QLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSISMPVWEDEGDDD 135
+L+NV +AL++L R +KLV+I + I DGN KL LGL+WT+ILH+ IS E +D
Sbjct: 270 RLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESED- 328
Query: 136 AKKQTPKQRLLGWIQNKIP-YLPI--TNFNQNWQDGKALGALVDSCAPGLCPDWESWDPQ 192
+ K+RLL W Q Y I NF W+DGK A++ P L D + Q
Sbjct: 329 ---MSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLI-DMNTVAVQ 384
Query: 193 KPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLSQ----FPK 239
+ N A A+ +GV +++ PE++ DE SV+TY+S FPK
Sbjct: 385 SNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK 434
>gi|34577047 dystonin isoform 1 [Homo sapiens]
Length = 5497
Score = 139 bits (350), Expect = 4e-32
Identities = 91/231 (39%), Positives = 129/231 (55%), Gaps = 16/231 (6%)
Query: 16 KIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYRKYHQRPTFRQM 75
K+Q+ TFT+W N+HL V K + +L DL DG LI+LLEVLS + R ++ R
Sbjct: 35 KVQKKTFTKWINQHLMKVRKHVNDLYEDLRDGHNLISLLEVLSGDTLPR---EKGRMRFH 91
Query: 76 QLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSISMPVWEDEGDDD 135
+L+NV +AL++L R +KLV+I + I DGN KL LGL+WT+ILH+ IS E +D
Sbjct: 92 RLQNVQIALDYLKRRQVKLVNIRNDDITDGNPKLTLGLIWTIILHFQISDIHVTGESED- 150
Query: 136 AKKQTPKQRLLGWIQNKIP-YLPI--TNFNQNWQDGKALGALVDSCAPGLCPDWESWDPQ 192
+ K+RLL W Q Y I NF W+DGK A++ P L D + Q
Sbjct: 151 ---MSAKERLLLWTQQATEGYAGIRCENFTTCWRDGKLFNAIIHKYRPDLI-DMNTVAVQ 206
Query: 193 KPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLSQ----FPK 239
+ N A A+ +GV +++ PE++ DE SV+TY+S FPK
Sbjct: 207 SNLANLEHAFYVAEK-IGVIRLLDPEDVDVSSPDEKSVITYVSSLYDAFPK 256
>gi|5902122 spectrin, beta, non-erythrocytic 2 [Homo sapiens]
Length = 2390
Score = 138 bits (348), Expect = 6e-32
Identities = 90/238 (37%), Positives = 136/238 (57%), Gaps = 16/238 (6%)
Query: 6 KDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYRK 65
K LA++ + +Q+ TFT+W N HL V R+G+L +DL DG L+ LLEVLS + +
Sbjct: 49 KALADER--EAVQKKTFTKWVNSHLARVTCRVGDLYSDLRDGRNLLRLLEVLSGEIL--- 103
Query: 66 YHQRPTFRQMQ---LENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYS 122
+PT +M+ LENV AL+FL + + L ++ S IVDGN +L LGLVWT+IL +
Sbjct: 104 --PKPTKGRMRIHCLENVDKALQFLKEQKVHLENMGSHDIVDGNHRLTLGLVWTIILRFQ 161
Query: 123 ISMPVWEDEGDDDAKKQTPKQRLLGWIQNK---IPYLPITNFNQNWQDGKALGALVDSCA 179
I E E D+ +K++ K LL W Q K P + + NF +W+DG A A+V
Sbjct: 162 IQDISVETE--DNKEKKSAKDALLLWCQMKTAGYPNVNVHNFTTSWRDGLAFNAIVHKHR 219
Query: 180 PGLCPDWESWDPQKPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLSQF 237
P L D+ES N + A A+ LG+ +++ PE++ DE S++TY++ +
Sbjct: 220 PDLL-DFESLKKCNAHYNLQNAFNLAEKELGLTKLLDPEDVNVDQPDEKSIITYVATY 276
>gi|115430237 spectrin, beta, non-erythrocytic 4 isoform sigma1
[Homo sapiens]
Length = 2564
Score = 138 bits (348), Expect = 6e-32
Identities = 89/235 (37%), Positives = 130/235 (55%), Gaps = 10/235 (4%)
Query: 6 KDLAEDAPWKKIQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYRK 65
K LA++ + +Q+ TFT+W N HL V IG+L DL DG L LLEVLS +++ R
Sbjct: 53 KALADER--EAVQKKTFTKWVNSHLARVGCHIGDLYVDLRDGFVLTRLLEVLSGEQLPRP 110
Query: 66 YHQRPTFRQMQLENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSISM 125
R R LENV AL+FL + + L ++ S IVDGN +L LGLVWT+IL + I
Sbjct: 111 TRGR--MRIHSLENVDKALQFLKEQRVHLENVGSHDIVDGNHRLTLGLVWTIILRFQIQ- 167
Query: 126 PVWEDEGDDDAKKQTPKQRLLGWIQNK---IPYLPITNFNQNWQDGKALGALVDSCAPGL 182
V + E +D+ + ++ K LL W Q K P + I NF +W+DG A AL+ P L
Sbjct: 168 -VIKIETEDNRETRSAKDALLLWCQMKTAGYPEVNIQNFTTSWRDGLAFNALIHRHRPDL 226
Query: 183 CPDWESWDPQKPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLSQF 237
D+ N + A + A+ LG+ +++ PE++ DE S++TY+ F
Sbjct: 227 V-DFSKLTKSNANYNLQRAFRTAEQHLGLARLLDPEDVNMEAPDEKSIITYVVSF 280
>gi|67782321 spectrin beta isoform a [Homo sapiens]
Length = 2328
Score = 137 bits (345), Expect = 1e-31
Identities = 84/227 (37%), Positives = 128/227 (56%), Gaps = 14/227 (6%)
Query: 17 IQQNTFTRWCNEHLKCVNKRIGNLQTDLSDGLRLIALLEVLSQKRMYRKYHQRPTFRQMQ 76
+Q+ TFT+W N HL V+ RI +L DL DG LI LLEVLS + + +PT +M+
Sbjct: 55 VQKKTFTKWVNSHLARVSCRITDLYKDLRDGRMLIKLLEVLSGEML-----PKPTKGKMR 109
Query: 77 ---LENVSVALEFLDRESIKLVSIDSKAIVDGNLKLILGLVWTLILHYSISMPVWEDEGD 133
LENV AL+FL + + L ++ S IVDGN +L+LGL+WT+IL + I V + +
Sbjct: 110 IHCLENVDKALQFLKEQRVHLENMGSHDIVDGNHRLVLGLIWTIILRFQIQDIVVQTQ-- 167
Query: 134 DDAKKQTPKQRLLGWIQNK---IPYLPITNFNQNWQDGKALGALVDSCAPGLCPDWESWD 190
+ + ++ K LL W Q K P++ +TNF +W+DG A AL+ P L D++
Sbjct: 168 EGRETRSAKDALLLWCQMKTAGYPHVNVTNFTSSWKDGLAFNALIHKHRPDLI-DFDKLK 226
Query: 191 PQKPVDNAREAMQQADDWLGVPQVITPEEIIHPDVDEHSVMTYLSQF 237
N A A+ LG+ ++ PE++ + DE S++TY+ F
Sbjct: 227 DSNARHNLEHAFNVAERQLGIIPLLDPEDVFTENPDEKSIITYVVAF 273
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.314 0.135 0.402
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 112,244,740
Number of Sequences: 37866
Number of extensions: 5876899
Number of successful extensions: 14035
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 54
Number of HSP's successfully gapped in prelim test: 52
Number of HSP's that attempted gapping in prelim test: 10047
Number of HSP's gapped (non-prelim): 446
length of query: 2602
length of database: 18,247,518
effective HSP length: 119
effective length of query: 2483
effective length of database: 13,741,464
effective search space: 34120055112
effective search space used: 34120055112
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.9 bits)
S2: 71 (32.0 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
Home |
Table of Contents |
Search text |
Search genes |
Search sequences |
Purchase |
FAQ |
Blog |
Help
Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.