Search of human proteins with 10190746

Search of human proteins with 10190746

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis)
[Homo sapiens]
         (336 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo...   662   0.0  
gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]        279   2e-75
gi|186928839 retinol dehydrogenase 12 [Homo sapiens]                  270   1e-72
gi|166795268 retinol dehydrogenase 11 [Homo sapiens]                  257   9e-69
gi|19923931 retinol dehydrogenase 13 isoform 2 [Homo sapiens]         239   3e-63
gi|146231950 dehydrogenase/reductase (SDR family) member 13 [Hom...   236   3e-62
gi|193804850 dehydrogenase/reductase (SDR family) X-linked [Homo...   202   4e-52
gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo s...   192   3e-49
gi|7705421 hydroxysteroid (17-beta) dehydrogenase 7 [Homo sapiens]     77   3e-14
gi|13375997 dehydrogenase/reductase (SDR family) member 12 isofo...    70   2e-12
gi|40254992 carbonic reductase 4 [Homo sapiens]                        65   9e-11
gi|72534732 dehydrogenase/reductase (SDR family) member 12 isofo...    64   2e-10
gi|4502601 carbonyl reductase 3 [Homo sapiens]                         62   6e-10
gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]              62   6e-10
gi|4502599 carbonyl reductase 1 [Homo sapiens]                         62   9e-10
gi|25282469 retinol dehydrogenase 10 [Homo sapiens]                    59   5e-09
gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]    59   5e-09
gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo...    59   6e-09
gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo s...    57   2e-08
gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]           57   3e-08
gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]         55   9e-08
gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo...    54   2e-07
gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]          54   2e-07
gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform ...    54   3e-07
gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo sap...    53   4e-07
gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A...    53   4e-07
gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]     52   6e-07
gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo ...    52   6e-07
gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]        52   6e-07
gi|18860884 WW domain-containing oxidoreductase isoform 2 [Homo ...    51   1e-06

>gi|10190746 retinol dehydrogenase 14 (all-trans and 9-cis) [Homo
           sapiens]
          Length = 336

 Score =  662 bits (1709), Expect = 0.0
 Identities = 336/336 (100%), Positives = 336/336 (100%)

Query: 1   MAVATAAAVLAALGGALWLAARRFVGPRVQRLRRGGDPGLMHGKTVLITGANSGLGRATA 60
           MAVATAAAVLAALGGALWLAARRFVGPRVQRLRRGGDPGLMHGKTVLITGANSGLGRATA
Sbjct: 1   MAVATAAAVLAALGGALWLAARRFVGPRVQRLRRGGDPGLMHGKTVLITGANSGLGRATA 60

Query: 61  AELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPGVSGVGELIVRELDLASLR 120
           AELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPGVSGVGELIVRELDLASLR
Sbjct: 61  AELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPGVSGVGELIVRELDLASLR 120

Query: 121 SVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQFGVNHLGHFLLTNLLLGLLK 180
           SVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQFGVNHLGHFLLTNLLLGLLK
Sbjct: 121 SVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQFGVNHLGHFLLTNLLLGLLK 180

Query: 181 SSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYSRSKLANILFTRELARRLEGTNV 240
           SSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYSRSKLANILFTRELARRLEGTNV
Sbjct: 181 SSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYSRSKLANILFTRELARRLEGTNV 240

Query: 241 TVNVLHPGIVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLASSPEVEGVSG 300
           TVNVLHPGIVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLASSPEVEGVSG
Sbjct: 241 TVNVLHPGIVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLASSPEVEGVSG 300

Query: 301 RYFGDCKEEELLPKAMDESVARKLWDISEVMVGLLK 336
           RYFGDCKEEELLPKAMDESVARKLWDISEVMVGLLK
Sbjct: 301 RYFGDCKEEELLPKAMDESVARKLWDISEVMVGLLK 336


>gi|225579078 retinol dehydrogenase 13 isoform 1 [Homo sapiens]
          Length = 331

 Score =  279 bits (714), Expect = 2e-75
 Identities = 149/295 (50%), Positives = 193/295 (65%), Gaps = 16/295 (5%)

Query: 43  GKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPG 102
           GKTV++TGAN+G+G+ TA EL R G  +I+ CRD  + E AA  +R E            
Sbjct: 38  GKTVIVTGANTGIGKQTALELARRGGNIILACRDMEKCEAAAKDIRGETLNH-------- 89

Query: 103 VSGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQFG 162
                 +  R LDLASL+S+R F  ++++EE R+D+LINNAG+ +CP+  TEDGFEMQFG
Sbjct: 90  -----HVNARHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTTEDGFEMQFG 144

Query: 163 VNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLN-SEQSYNKSFCYSRSK 221
           VNHLGHFLLTNLLL  LK+SAPSRI+ +SS  +  G I+FDDLN   + YN    Y +SK
Sbjct: 145 VNHLGHFLLTNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSK 204

Query: 222 LANILFTRELARRLEGTNVTVNVLHPGIVRTNLGRH--IHIPLLVKPLFNLVSWAFFKTP 279
           LA +LFT+EL+RRL+G+ VTVN LHPG+ RT LGRH  IH           + W   K+P
Sbjct: 205 LAIVLFTKELSRRLQGSGVTVNALHPGVARTELGRHTGIHGSTFSSTTLGPIFWLLVKSP 264

Query: 280 VEGAQTSIYLASSPEVEGVSGRYFGDCKEEELLPKAMDESVARKLWDISEVMVGL 334
              AQ S YLA + E+  VSG+YF   K++   P+A DE VAR+LW  S  +VGL
Sbjct: 265 ELAAQPSTYLAVAEELADVSGKYFDGLKQKAPAPEAEDEEVARRLWAESARLVGL 319


>gi|186928839 retinol dehydrogenase 12 [Homo sapiens]
          Length = 316

 Score =  270 bits (691), Expect = 1e-72
 Identities = 145/313 (46%), Positives = 201/313 (64%), Gaps = 20/313 (6%)

Query: 25  VGPRVQRLRRGG---DPGLMHGKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAE 81
           V P +++   GG       + GK V+ITGAN+G+G+ TA EL   GARV + CRD  + E
Sbjct: 18  VAPSIRKFFAGGVCRTNVQLPGKVVVITGANTGIGKETARELASRGARVYIACRDVLKGE 77

Query: 82  EAAGQLRRELRQAAECGPEPGVSGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLIN 141
            AA ++R + + +             +++VR+LDL+  +S+RAF +  L EE +L +LIN
Sbjct: 78  SAASEIRVDTKNS-------------QVLVRKLDLSDTKSIRAFAEGFLAEEKQLHILIN 124

Query: 142 NAGIFQCPYMKTEDGFEMQFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDIN 201
           NAG+  CPY KT DGFE   GVNHLGHFLLT LLL  LK SAP+R+V VSS  +  G I 
Sbjct: 125 NAGVMMCPYSKTADGFETHLGVNHLGHFLLTYLLLERLKVSAPARVVNVSSVAHHIGKIP 184

Query: 202 FDDLNSEQSYNKSFCYSRSKLANILFTRELARRLEGTNVTVNVLHPGIVRTNLGRHIHIP 261
           F DL SE+ Y++ F Y  SKLAN+LFTRELA+RL+GT VT   +HPG+VR+ L RH  + 
Sbjct: 185 FHDLQSEKRYSRGFAYCHSKLANVLFTRELAKRLQGTGVTTYAVHPGVVRSELVRHSSLL 244

Query: 262 LLVKPLFNLVSWAFFKTPVEGAQTSIYLASSPEVEGVSGRYFGDCKEEELLPKAMDESVA 321
            L+  LF+     F KT  EGAQTS++ A +  +E +SG+YF DCK   + P+A +   A
Sbjct: 245 CLLWRLFS----PFVKTAREGAQTSLHCALAEGLEPLSGKYFSDCKRTWVSPRARNNKTA 300

Query: 322 RKLWDISEVMVGL 334
            +LW++S  ++G+
Sbjct: 301 ERLWNVSCELLGI 313


>gi|166795268 retinol dehydrogenase 11 [Homo sapiens]
          Length = 318

 Score =  257 bits (657), Expect = 9e-69
 Identities = 140/292 (47%), Positives = 190/292 (65%), Gaps = 17/292 (5%)

Query: 43  GKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPG 102
           GK V++TGAN+G+G+ TA EL + GARV + CRD  + E  A +++              
Sbjct: 41  GKVVVVTGANTGIGKETAKELAQRGARVYLACRDVEKGELVAKEIQT------------- 87

Query: 103 VSGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQFG 162
            +G  +++VR+LDL+  +S+RAF +  L EE  L VLINNAG+  CPY KT DGFEM  G
Sbjct: 88  TTGNQQVLVRKLDLSDTKSIRAFAKGFLAEEKHLHVLINNAGVMMCPYSKTADGFEMHIG 147

Query: 163 VNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYSRSKL 222
           VNHLGHFLLT+LLL  LK SAPSRIV VSS  +  G I+F +L  E+ YN    Y  SKL
Sbjct: 148 VNHLGHFLLTHLLLEKLKESAPSRIVNVSSLAHHLGRIHFHNLQGEKFYNAGLAYCHSKL 207

Query: 223 ANILFTRELARRLEGTNVTVNVLHPGIVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEG 282
           ANILFT+ELARRL+G+ VT   +HPG V++ L RH      +  LF+     F KTP +G
Sbjct: 208 ANILFTQELARRLKGSGVTTYSVHPGTVQSELVRHSSFMRWMWWLFSF----FIKTPQQG 263

Query: 283 AQTSIYLASSPEVEGVSGRYFGDCKEEELLPKAMDESVARKLWDISEVMVGL 334
           AQTS++ A +  +E +SG +F DC    +  +A +E++AR+LWD+S  ++GL
Sbjct: 264 AQTSLHCALTEGLEILSGNHFSDCHVAWVSAQARNETIARRLWDVSCDLLGL 315


>gi|19923931 retinol dehydrogenase 13 isoform 2 [Homo sapiens]
          Length = 260

 Score =  239 bits (609), Expect = 3e-63
 Identities = 124/226 (54%), Positives = 158/226 (69%), Gaps = 3/226 (1%)

Query: 112 RELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQFGVNHLGHFLL 171
           R LDLASL+S+R F  ++++EE R+D+LINNAG+ +CP+  TEDGFEMQFGVNHLGHFLL
Sbjct: 23  RHLDLASLKSIREFAAKIIEEEERVDILINNAGVMRCPHWTTEDGFEMQFGVNHLGHFLL 82

Query: 172 TNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLN-SEQSYNKSFCYSRSKLANILFTRE 230
           TNLLL  LK+SAPSRI+ +SS  +  G I+FDDLN   + YN    Y +SKLA +LFT+E
Sbjct: 83  TNLLLDKLKASAPSRIINLSSLAHVAGHIDFDDLNWQTRKYNTKAAYCQSKLAIVLFTKE 142

Query: 231 LARRLEGTNVTVNVLHPGIVRTNLGRH--IHIPLLVKPLFNLVSWAFFKTPVEGAQTSIY 288
           L+RRL+G+ VTVN LHPG+ RT LGRH  IH           + W   K+P   AQ S Y
Sbjct: 143 LSRRLQGSGVTVNALHPGVARTELGRHTGIHGSTFSSTTLGPIFWLLVKSPELAAQPSTY 202

Query: 289 LASSPEVEGVSGRYFGDCKEEELLPKAMDESVARKLWDISEVMVGL 334
           LA + E+  VSG+YF   K++   P+A DE VAR+LW  S  +VGL
Sbjct: 203 LAVAEELADVSGKYFDGLKQKAPAPEAEDEEVARRLWAESARLVGL 248


>gi|146231950 dehydrogenase/reductase (SDR family) member 13 [Homo
           sapiens]
          Length = 377

 Score =  236 bits (601), Expect = 3e-62
 Identities = 140/324 (43%), Positives = 189/324 (58%), Gaps = 18/324 (5%)

Query: 13  LGGALWLAARRFVGPRVQRLRRGGDPGLMHGKTVLITGANSGLGRATAAELLRLGARVIM 72
           LG  L L A   V   + +    G  G + G+T ++TGANSG+G+ TA EL R GARV++
Sbjct: 6   LGAGLLLGAYVLVYYNLVKAPPCGGMGNLRGRTAVVTGANSGIGKMTALELARRGARVVL 65

Query: 73  GCRDRARAEEAAGQLRRELRQAAECGPEPGVSGVGELIVRELDLASLRSVRAFCQEMLQE 132
            CR + R E AA  LR+E             SG  E+I   LDLASL SVRAF    L  
Sbjct: 66  ACRSQERGEAAAFDLRQE-------------SGNNEVIFMALDLASLASVRAFATAFLSS 112

Query: 133 EPRLDVLINNAGIFQCPYMKTEDGFEMQFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSS 192
           EPRLD+LI+NAGI  C   +T + F +   VNH+G FLLT+LLL  LK+ APSR+VVV+S
Sbjct: 113 EPRLDILIHNAGISSCG--RTREAFNLLLRVNHIGPFLLTHLLLPCLKACAPSRVVVVAS 170

Query: 193 KLYKYGDINFDDLNSEQS--YNKSFCYSRSKLANILFTRELARRLEGTNVTVNVLHPGIV 250
             +  G ++F  L+        +   Y+ +KLAN+LF RELA +LE T VT    HPG V
Sbjct: 171 AAHCRGRLDFKRLDRPVVGWRQELRAYADTKLANVLFARELANQLEATGVTCYAAHPGPV 230

Query: 251 RTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLASSPEVEGVSGRYFGDCKEEE 310
            + L    H+P  ++PL   ++W   + P  GAQT +Y A    +E +SGRYF +C  EE
Sbjct: 231 NSELFLR-HVPGWLRPLLRPLAWLVLRAPRGGAQTPLYCALQEGIEPLSGRYFANCHVEE 289

Query: 311 LLPKAMDESVARKLWDISEVMVGL 334
           + P A D+  A +LW+ S+ + GL
Sbjct: 290 VPPAARDDRAAHRLWEASKRLAGL 313


>gi|193804850 dehydrogenase/reductase (SDR family) X-linked [Homo
           sapiens]
          Length = 330

 Score =  202 bits (513), Expect = 4e-52
 Identities = 130/345 (37%), Positives = 191/345 (55%), Gaps = 32/345 (9%)

Query: 1   MAVATAAAVLAALGGALWLAARRFVGPRVQRLRRGG--DPGL--MHGKTVLITGANSGLG 56
           ++ A AA  + A+G A+ LA       ++ R  RGG  +P       +  ++TG   G+G
Sbjct: 4   LSAARAALRVYAVGAAVILA-------QLLRRCRGGFLEPVFPPRPDRVAIVTGGTDGIG 56

Query: 57  RATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPGVSGVGELIVRELDL 116
            +TA  L RLG  VI+   + ++A++   +++ E                 ++     DL
Sbjct: 57  YSTAKHLARLGMHVIIAGNNDSKAKQVVSKIKEETLN-------------DKVEFLYCDL 103

Query: 117 ASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQFGVNHLGHFLLTNLLL 176
           AS+ S+R F Q+   ++  L VLINNAG+   P  KT DGFE  FG+N+LGHFLLTNLLL
Sbjct: 104 ASMTSIRQFVQKFKMKKIPLHVLINNAGVMMVPQRKTRDGFEEHFGLNYLGHFLLTNLLL 163

Query: 177 GLLKSSA----PSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYSRSKLANILFTRELA 232
             LK S      +R+V VSS  +   ++N DDL S   Y+    Y++SKLA +LFT  L 
Sbjct: 164 DTLKESGSPGHSARVVTVSSATHYVAELNMDDLQSSACYSPHAAYAQSKLALVLFTYHLQ 223

Query: 233 RRL--EGTNVTVNVLHPGIVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLA 290
           R L  EG++VT NV+ PG+V T++ +H+      +    L+ W  FKTP EGA TSIY A
Sbjct: 224 RLLAAEGSHVTANVVDPGVVNTDVYKHVF--WATRLAKKLLGWLLFKTPDEGAWTSIYAA 281

Query: 291 SSPEVEGVSGRYFGDCKEEELLPKAMDESVARKLWDISEVMVGLL 335
            +PE+EGV G Y  + KE + L    ++ + ++LW  S  M G+L
Sbjct: 282 VTPELEGVGGHYLYNEKETKSLHVTYNQKLQQQLWSKSCEMTGVL 326


>gi|7706523 WW domain-containing oxidoreductase isoform 1 [Homo
           sapiens]
          Length = 414

 Score =  192 bits (489), Expect = 3e-49
 Identities = 119/298 (39%), Positives = 165/298 (55%), Gaps = 24/298 (8%)

Query: 43  GKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPG 102
           GK V++TGANSG+G  TA      GA VI+ CR+ ARA EA  ++  E  +A        
Sbjct: 124 GKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWHKA-------- 175

Query: 103 VSGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQFG 162
                ++    LDLA LRSV+ F +    +   L VL+ NA  F  P+  T+DG E  F 
Sbjct: 176 -----KVEAMTLDLALLRSVQHFAEAFKAKNVPLHVLVCNAATFALPWSLTKDGLETTFQ 230

Query: 163 VNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDIN-------FDDLN-SEQSYNKS 214
           VNHLGHF L  LL  +L  SAP+R++VVSS+ +++ DIN       F  L+ ++  Y   
Sbjct: 231 VNHLGHFYLVQLLQDVLCRSAPARVIVVSSESHRFTDINDSLGKLDFSRLSPTKNDYWAM 290

Query: 215 FCYSRSKLANILFTRELARRLEGTNVTVNVLHPGIVRTNLGRHIHIPLLVKPLFNLVSWA 274
             Y+RSKL NILF+ EL RRL    VT N +HPG     +  +IH    V  L   ++  
Sbjct: 291 LAYNRSKLCNILFSNELHRRLSPRGVTSNAVHPG---NMMYSNIHRSWWVYTLLFTLARP 347

Query: 275 FFKTPVEGAQTSIYLASSPEVEGVSGRYFGDCKEEELLPKAMDESVARKLWDISEVMV 332
           F K+  +GA T++Y A+ PE+EG+ G YF +C      P+A  E  AR LW +SE ++
Sbjct: 348 FTKSMQQGAATTVYCAAVPELEGLGGMYFNNCCRCMPSPEAQSEETARTLWALSERLI 405


>gi|7705421 hydroxysteroid (17-beta) dehydrogenase 7 [Homo sapiens]
          Length = 341

 Score = 76.6 bits (187), Expect = 3e-14
 Identities = 78/285 (27%), Positives = 116/285 (40%), Gaps = 55/285 (19%)

Query: 44  KTVLITGANSGLGRATAAELLRLG--ARVIMGCRDRARAEEAAGQLRRELRQAAECGPEP 101
           K VLITGA+SG+G A    LL       + + CR+ ++AE             A C    
Sbjct: 3   KVVLITGASSGIGLALCKRLLAEDDELHLCLACRNMSKAE-------------AVCAALL 49

Query: 102 GVSGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMK--------- 152
                 E+ + ++D+++L+SV    +E+ Q   RLD +  NAGI   P +          
Sbjct: 50  ASHPTAEVTIVQVDVSNLQSVFRASKELKQRFQRLDCIYLNAGIMPNPQLNIKALFFGLF 109

Query: 153 ---------------------TEDGFEMQFGVNHLGHFLLTNLLLGLL-KSSAPSRIVVV 190
                                T DG +  F  N  GHF+L   L  LL  S  PS+++  
Sbjct: 110 SRKVIHMFSTAEGLLTQGDKITADGLQEVFETNVFGHFILIRELEPLLCHSDNPSQLIWT 169

Query: 191 SSKLYKYGDINFDDLNSEQSYNKSFCYSRSKLANILFTRELARRLEGTNVTVNVLHPGIV 250
           SS+  +  + + +D    +       YS SK A  L +  L R      +  NV  PG  
Sbjct: 170 SSRSARKSNFSLEDFQHSKGKEP---YSSSKYATDLLSVALNRNFNQQGLYSNVACPGTA 226

Query: 251 RTNLGRHIHIPL---LVKPLFNLVSW---AFFKTPVEGAQTSIYL 289
            TNL   I  P    L+ P   L+ +   AF  TP  G +  ++L
Sbjct: 227 LTNLTYGILPPFIWTLLMPAILLLRFFANAFTLTPYNGTEALVWL 271


>gi|13375997 dehydrogenase/reductase (SDR family) member 12 isoform
           2 [Homo sapiens]
          Length = 242

 Score = 70.5 bits (171), Expect = 2e-12
 Identities = 57/192 (29%), Positives = 93/192 (48%), Gaps = 11/192 (5%)

Query: 114 LDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQFGVNHLGHFLLTN 173
           +DL+  + +  F +   QE  +L VLINNAG        TEDG E  F  N LG ++LT 
Sbjct: 49  VDLSDPKQIWKFVENFKQEH-KLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTT 107

Query: 174 LLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQS-YNKSFCYSRSKLANILFTRELA 232
            L+ +L+     R++ VSS       +N +DL SE++ ++ +  Y+++K   ++ T   A
Sbjct: 108 GLIPVLEKEHDPRVITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWA 167

Query: 233 RRLEGTNVTVNVLHPGIVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLA-S 291
           +      +  + +HPG   T   R         P F+       ++  +GA T ++LA S
Sbjct: 168 QGHPA--IHFSSMHPGWADTPGVRQ------AMPGFHARFGDRLRSEAQGADTMLWLALS 219

Query: 292 SPEVEGVSGRYF 303
           S      SGR+F
Sbjct: 220 SAAAAQPSGRFF 231


>gi|40254992 carbonic reductase 4 [Homo sapiens]
          Length = 237

 Score = 65.1 bits (157), Expect = 9e-11
 Identities = 69/256 (26%), Positives = 110/256 (42%), Gaps = 36/256 (14%)

Query: 44  KTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPGV 103
           K   + G + G+GRA A  + R G R+ +  R+   A+ AAG L                
Sbjct: 3   KVCAVFGGSRGIGRAVAQLMARKGYRLAVIARNLEGAKAAAGDLG--------------- 47

Query: 104 SGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQFGV 163
              G+ +    D+A    V+   +E+ +   R++ L+N AGI         DG  ++   
Sbjct: 48  ---GDHLAFSCDVAKEHDVQNTFEELEKHLGRVNFLVNAAGI-------NRDGLLVRTKT 97

Query: 164 NHLGHFLLTNLLLGLLKSSAPSRIVVVSS--KLYKYGDINFDDLNSEQSYNKSFCYSRSK 221
             +   L TNLL  +L   A  R ++      +   G I     NS QS      YS SK
Sbjct: 98  EDMVSQLHTNLLGSMLTCKAAMRTMIQQQGGSIVNVGSIVGLKGNSGQSV-----YSASK 152

Query: 222 LANILFTRELARRLEGTNVTVNVLHPGIVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVE 281
              + F+R LA+ +    + VNV+ PG V T++ + +    L K   N+    F +T +E
Sbjct: 153 GGLVGFSRALAKEVARKKIRVNVVAPGFVHTDMTKDLKEEHLKK---NIPLGRFGET-IE 208

Query: 282 GAQTSIYLASSPEVEG 297
            A   ++L  SP + G
Sbjct: 209 VAHAVVFLLESPYITG 224


>gi|72534732 dehydrogenase/reductase (SDR family) member 12 isoform
           1 [Homo sapiens]
          Length = 271

 Score = 63.5 bits (153), Expect = 2e-10
 Identities = 42/136 (30%), Positives = 71/136 (52%), Gaps = 4/136 (2%)

Query: 114 LDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQFGVNHLGHFLLTN 173
           +DL+  + +  F +   QE  +L VLINNAG        TEDG E  F  N LG ++LT 
Sbjct: 49  VDLSDPKQIWKFVENFKQEH-KLHVLINNAGCMVNKRELTEDGLEKNFAANTLGVYILTT 107

Query: 174 LLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQS-YNKSFCYSRSKLANILFTRELA 232
            L+ +L+     R++ VSS       +N +DL SE++ ++ +  Y+++K   ++ T   A
Sbjct: 108 GLIPVLEKEHDPRVITVSSGGMLVQKLNTNDLQSERTPFDGTMVYAQNKRQQVVLTERWA 167

Query: 233 RRLEGTNVTVNVLHPG 248
           +      +  + +HPG
Sbjct: 168 QGHPA--IHFSSMHPG 181


>gi|4502601 carbonyl reductase 3 [Homo sapiens]
          Length = 277

 Score = 62.4 bits (150), Expect = 6e-10
 Identities = 77/291 (26%), Positives = 119/291 (40%), Gaps = 79/291 (27%)

Query: 44  KTVLITGANSGLGRATAAELLR-LGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPG 102
           +  L+TGAN G+G A A EL R     V++  RD AR + A  QL+ E       G  P 
Sbjct: 6   RVALVTGANRGIGLAIARELCRQFSGDVVLTARDVARGQAAVQQLQAE-------GLSPR 58

Query: 103 VSGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGF----- 157
                     +LD+  L+S+RA    + +E   L+VL+NNA +      K++D       
Sbjct: 59  F--------HQLDIDDLQSIRALRDFLRKEYGGLNVLVNNAAV----AFKSDDPMPFDIK 106

Query: 158 -EMQFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSS------------------------ 192
            EM    N      + N LL ++K     R+V +SS                        
Sbjct: 107 AEMTLKTNFFATRNMCNELLPIMKPH--GRVVNISSLQCLRAFENCSEDLQERFHSETLT 164

Query: 193 ------KLYKYGDINFDDLNSEQSYNKSFCYSRSKLANILFTRELARRLE----GTNVTV 242
                  + K+ +   ++++  + +  S  Y  SKL   + +R LARRL+       + V
Sbjct: 165 EGDLVDLMKKFVEDTKNEVHEREGWPNS-PYGVSKLGVTVLSRILARRLDEKRKADRILV 223

Query: 243 NVLHPGIVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLASSP 293
           N   PG V+T++     I                +T  EGA+T +YLA  P
Sbjct: 224 NACCPGPVKTDMDGKDSI----------------RTVEEGAETPVYLALLP 258


>gi|7705925 dicarbonyl/L-xylulose reductase [Homo sapiens]
          Length = 244

 Score = 62.4 bits (150), Expect = 6e-10
 Identities = 59/218 (27%), Positives = 97/218 (44%), Gaps = 40/218 (18%)

Query: 43  GKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAEC-GPEP 101
           G+ VL+TGA  G+GR T   L   GARV+   R +A  +              EC G EP
Sbjct: 7   GRRVLVTGAGKGIGRGTVQALHATGARVVAVSRTQADLDSL----------VRECPGIEP 56

Query: 102 GVSGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGI-FQCPYMK-TEDGFEM 159
               +G+    E  L S+  V              D+L+NNA +    P+++ T++ F+ 
Sbjct: 57  VCVDLGDWEATERALGSVGPV--------------DLLVNNAAVALLQPFLEVTKEAFDR 102

Query: 160 QFGVNHLGHFLLTNLLL-GLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYS 218
            F VN      ++ ++  GL+    P  IV VSS+             S+++      Y 
Sbjct: 103 SFEVNLRAVIQVSQIVARGLIARGVPGAIVNVSSQC------------SQRAVTNHSVYC 150

Query: 219 RSKLANILFTRELARRLEGTNVTVNVLHPGIVRTNLGR 256
            +K A  + T+ +A  L    + VN ++P +V T++G+
Sbjct: 151 STKGALDMLTKVMALELGPHKIRVNAVNPTVVMTSMGQ 188


>gi|4502599 carbonyl reductase 1 [Homo sapiens]
          Length = 277

 Score = 61.6 bits (148), Expect = 9e-10
 Identities = 80/305 (26%), Positives = 128/305 (41%), Gaps = 78/305 (25%)

Query: 47  LITGANSGLGRATAAELLRL-GARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPGVSG 105
           L+TG N G+G A   +L RL    V++  RD  R + A  QL+ E       G  P    
Sbjct: 9   LVTGGNKGIGLAIVRDLCRLFSGDVVLTARDVTRGQAAVQQLQAE-------GLSPRF-- 59

Query: 106 VGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTED------GFEM 159
                  +LD+  L+S+RA    + +E   LDVL+NNAGI      K  D        E+
Sbjct: 60  ------HQLDIDDLQSIRALRDFLRKEYGGLDVLVNNAGI----AFKVADPTPFHIQAEV 109

Query: 160 QFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSS---------------KLYKYGDINFDD 204
               N  G   +   LL L+K     R+V VSS               + ++   I  ++
Sbjct: 110 TMKTNFFGTRDVCTELLPLIKPQ--GRVVNVSSIMSVRALKSCSPELQQKFRSETITEEE 167

Query: 205 L---------NSEQSYNK-----SFCYSRSKLANILFTRELARRL----EGTNVTVNVLH 246
           L         ++++  ++     S  Y  +K+   + +R  AR+L    +G  + +N   
Sbjct: 168 LVGLMNKFVEDTKKGVHQKEGWPSSAYGVTKIGVTVLSRIHARKLSEQRKGDKILLNACC 227

Query: 247 PGIVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEGAQTSIYLA-SSPEVEGVSGRYFGD 305
           PG VRT                ++      K+P EGA+T +YLA   P+ EG  G++  +
Sbjct: 228 PGWVRT----------------DMAGPKATKSPEEGAETPVYLALLPPDAEGPHGQFVSE 271

Query: 306 CKEEE 310
            + E+
Sbjct: 272 KRVEQ 276


>gi|25282469 retinol dehydrogenase 10 [Homo sapiens]
          Length = 341

 Score = 59.3 bits (142), Expect = 5e-09
 Identities = 62/243 (25%), Positives = 97/243 (39%), Gaps = 35/243 (14%)

Query: 43  GKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELR--QAAECGPE 100
           G+  LITGA SGLGR  A E  R  A +++   +    EE AG +R   R  +AA+    
Sbjct: 36  GQVCLITGAGSGLGRLFALEFARRRALLVLWDINTQSNEETAGMVRHIYRDLEAADAAAL 95

Query: 101 PGVSGVGELI--------VRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGI------F 146
              +G  E++            D+    +V    + + +E   + VL+NNAG+       
Sbjct: 96  QAGNGEEEILPHCNLQVFTYTCDVGKRENVYLTAERVRKEVGEVSVLVNNAGVVSGHHLL 155

Query: 147 QCPYMKTEDGFEMQFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLN 206
           +CP    ++  E    VN   HF  T   L  +       IV V+S L  +     +D  
Sbjct: 156 ECP----DELIERTMMVNCHAHFWTTKAFLPTMLEINHGHIVTVASSLGLFSTAGVED-- 209

Query: 207 SEQSYNKSFCYSRSKLANILFTRELARRL---EGTNVTVNVLHPGIVRTNLGRHIHIPLL 263
                     Y  SK   + F   L+  L   E   +   ++ P +V T + R   I   
Sbjct: 210 ----------YCASKFGVVGFHESLSHELKAAEKDGIKTTLVCPYLVDTGMFRGCRIRKE 259

Query: 264 VKP 266
           ++P
Sbjct: 260 IEP 262


>gi|19743808 hydroxysteroid (17-beta) dehydrogenase 6 [Homo sapiens]
          Length = 317

 Score = 59.3 bits (142), Expect = 5e-09
 Identities = 63/220 (28%), Positives = 93/220 (42%), Gaps = 39/220 (17%)

Query: 41  MHGKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPE 100
           +  K V ITG +SG G   A +L   G RV+  C     AE+  GQ    L         
Sbjct: 27  LQDKYVFITGCDSGFGNLLARQLDARGLRVLAACLTEKGAEQLRGQTSDRLETVT----- 81

Query: 101 PGVSGVGELIVRELDLASLRSVRAFCQEMLQE--EPRLDVLINNAGIFQ----CPYMKTE 154
                        LD+  + S+ A  Q + +   +  L  L+NNAGI      C ++ TE
Sbjct: 82  -------------LDVTKMESIAAATQWVKEHVGDRGLWGLVNNAGILTPITLCEWLNTE 128

Query: 155 DGFEMQFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKS 214
           D   M   VN +G   +T  +L L++  A  RIV VSS L   G + F        +   
Sbjct: 129 DSMNM-LKVNLIGVIQVTLSMLPLVR-RARGRIVNVSSIL---GRVAF--------FVGG 175

Query: 215 FCYSRSKLANILFTRELARRLEGTNVTVNVLHPGIVRTNL 254
           +C   SK     F+  L R ++   V ++++ PG  RT +
Sbjct: 176 YCV--SKYGVEAFSDILRREIQHFGVKISIVEPGYFRTGM 213


>gi|20149619 dehydrogenase/reductase (SDR family) member 7B [Homo
           sapiens]
          Length = 325

 Score = 58.9 bits (141), Expect = 6e-09
 Identities = 71/256 (27%), Positives = 107/256 (41%), Gaps = 29/256 (11%)

Query: 1   MAVATAAAVLAALGGALWLAARRFVGPRVQRLRRGGDPGLMHGKTVLITGANSGLGRATA 60
           M   T+ A+L  L G L +    F   R+ +  RG     +    V+ITGA SGLG+  A
Sbjct: 16  MDFITSTAILPLLFGCLGV----FGLFRLLQWVRG--KAYLRNAVVVITGATSGLGKECA 69

Query: 61  AELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPGVSGVGELIVRELDLASLR 120
                 GA++++  R+    EE    L REL  +     +       +  +   DL    
Sbjct: 70  KVFYAAGAKLVLCGRNGGALEE----LIRELTASHATKVQ-----THKPYLVTFDLTDSG 120

Query: 121 SVRAFCQEMLQEEPRLDVLINNAGI-FQCPYMKTE-DGFEMQFGVNHLGHFLLTNLLLGL 178
           ++ A   E+LQ    +D+L+NNAGI ++   M T  D  +     N+ G   LT  LL  
Sbjct: 121 AIVAAAAEILQCFGYVDILVNNAGISYRGTIMDTTVDVDKRVMETNYFGPVALTKALLPS 180

Query: 179 LKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYSRSKLANILFTRELARRLEGT 238
           +       IV +SS            +  + S      Y+ SK A   F   L   +E  
Sbjct: 181 MIKRRQGHIVAISS------------IQGKMSIPFRSAYAASKHATQAFFDCLRAEMEQY 228

Query: 239 NVTVNVLHPGIVRTNL 254
            + V V+ PG + TNL
Sbjct: 229 EIEVTVISPGYIHTNL 244


>gi|7706318 dehydrogenase/reductase (SDR family) member 7 [Homo
           sapiens]
          Length = 339

 Score = 57.0 bits (136), Expect = 2e-08
 Identities = 49/151 (32%), Positives = 73/151 (48%), Gaps = 13/151 (8%)

Query: 46  VLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPGVSG 105
           V +TGA+SG+G   A +L +LG  +++  R   R  E     RR L        E G   
Sbjct: 53  VWVTGASSGIGEELAYQLSKLGVSLVLSAR---RVHELERVKRRCL--------ENGNLK 101

Query: 106 VGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPY-MKTE-DGFEMQFGV 163
             +++V  LDL    S  A  + +LQE  R+D+L+NN G+ Q    M T  D +     +
Sbjct: 102 EKDILVLPLDLTDTGSHEAATKAVLQEFGRIDILVNNGGMSQRSLCMDTSLDVYRKLIEL 161

Query: 164 NHLGHFLLTNLLLGLLKSSAPSRIVVVSSKL 194
           N+LG   LT  +L  +      +IV V+S L
Sbjct: 162 NYLGTVSLTKCVLPHMIERKQGKIVTVNSIL 192


>gi|15277342 estradiol 17 beta-dehydrogenase 8 [Homo sapiens]
          Length = 261

 Score = 56.6 bits (135), Expect = 3e-08
 Identities = 63/249 (25%), Positives = 107/249 (42%), Gaps = 25/249 (10%)

Query: 47  LITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPGVSGV 106
           L+TGA SG+GRA +  L   GA V     DRA A+E        +R     G + G    
Sbjct: 15  LVTGAGSGIGRAVSVRLAGEGATVAACDLDRAAAQET-------VRLLGGPGSKEGPPR- 66

Query: 107 GELIVRELDLASLRSVRAFCQEMLQEEPR-LDVLINNAGIFQCPYM--KTEDGFEMQFGV 163
           G     + D++  R+ R   +++     R   V+++ AGI Q  ++   +ED ++    V
Sbjct: 67  GNHAAFQADVSEARAARCLLEQVQACFSRPPSVVVSCAGITQDEFLLHMSEDDWDKVIAV 126

Query: 164 NHLGHFLLTNLLL-GLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYSRSKL 222
           N  G FL+T      L+ +     I+ +SS + K G++   +            Y+ SK 
Sbjct: 127 NLKGTFLVTQAAAQALVSNGCRGSIINISSIVGKVGNVGQTN------------YAASKA 174

Query: 223 ANILFTRELARRLEGTNVTVNVLHPGIVRTNLGRHIHIPLLVKPLFNLVSWAFFKTPVEG 282
             I  T+  AR L    +  N + PG + T + + +    +V  +  ++       P + 
Sbjct: 175 GVIGLTQTAARELGRHGIRCNSVLPGFIATPMTQKVP-QKVVDKITEMIPMGHLGDPEDV 233

Query: 283 AQTSIYLAS 291
           A    +LAS
Sbjct: 234 ADVVAFLAS 242


>gi|142976729 estradiol 17-beta-dehydrogenase 11 [Homo sapiens]
          Length = 300

 Score = 55.1 bits (131), Expect = 9e-08
 Identities = 61/217 (28%), Positives = 95/217 (43%), Gaps = 36/217 (16%)

Query: 43  GKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPG 102
           G+ VLITGA  G+GR TA E  +L +++++   ++   EE           AA+C     
Sbjct: 36  GEIVLITGAGHGIGRLTAYEFAKLKSKLVLWDINKHGLEET----------AAKC----- 80

Query: 103 VSGVGELI-VRELDLASLRSVRAFCQEMLQEEPRLDVLINNAG-IFQCPYMKTED-GFEM 159
             G+G  +    +D ++   + +  +++  E   + +L+NNAG ++      T+D   E 
Sbjct: 81  -KGLGAKVHTFVVDCSNREDIYSSAKKVKAEIGDVSILVNNAGVVYTSDLFATQDPQIEK 139

Query: 160 QFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYSR 219
            F VN L HF  T   L  +  +    IV V+S     G ++   L           Y  
Sbjct: 140 TFEVNVLAHFWTTKAFLPAMTKNNHGHIVTVASAA---GHVSVPFL---------LAYCS 187

Query: 220 SKLANILF----TRELARRLEGTNVTVNVLHPGIVRT 252
           SK A + F    T ELA  L+ T V    L P  V T
Sbjct: 188 SKFAAVGFHKTLTDELA-ALQITGVKTTCLCPNFVNT 223


>gi|59889578 dehydrogenase/reductase (SDR family) member 10 [Homo
           sapiens]
          Length = 270

 Score = 54.3 bits (129), Expect = 2e-07
 Identities = 59/215 (27%), Positives = 90/215 (41%), Gaps = 35/215 (16%)

Query: 43  GKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPG 102
           GK V++TG   G+G       +  GARV++  +D    E     L +EL         PG
Sbjct: 9   GKVVVVTGGGRGIGAGIVRAFVNSGARVVICDKD----ESGGRALEQEL---------PG 55

Query: 103 VSGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIF---QCPYMKTEDGFEM 159
              +   + +E D+ +L S      E ++   RLD ++NNAG     Q P   +  GF  
Sbjct: 56  AVFILCDVTQEDDVKTLVS------ETIRRFGRLDCVVNNAGHHPPPQRPEETSAQGFRQ 109

Query: 160 QFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYSR 219
              +N LG + LT L L  L+ S    ++ +SS +   G              ++  Y  
Sbjct: 110 LLELNLLGTYTLTKLALPYLRKS-QGNVINISSLVGAIGQA------------QAVPYVA 156

Query: 220 SKLANILFTRELARRLEGTNVTVNVLHPGIVRTNL 254
           +K A    T+ LA       V VN + PG + T L
Sbjct: 157 TKGAVTAMTKALALDESPYGVRVNCISPGNIWTPL 191


>gi|7657478 retinol dehydrogenase 8 (all-trans) [Homo sapiens]
          Length = 311

 Score = 53.9 bits (128), Expect = 2e-07
 Identities = 64/214 (29%), Positives = 94/214 (43%), Gaps = 34/214 (15%)

Query: 44  KTVLITGANSGLGRATAAELL---RLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPE 100
           +TVLI+G +SG+G   A +L    +   +V+   RD  + E         L Q       
Sbjct: 6   RTVLISGCSSGIGLELAVQLAHDPKKRYQVVATMRDLGKKETLEAAAGEALGQT------ 59

Query: 101 PGVSGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQ 160
                   L V +LD+ S  SV A C   +Q E  +DVL+NNAG+     ++      MQ
Sbjct: 60  --------LTVAQLDVCSDESV-AQCLSCIQGE--VDVLVNNAGMGLVGPLEGLSLAAMQ 108

Query: 161 --FGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYS 218
             F  N  G   L   +L  +K      IVV+SS +   G I F+D+           Y+
Sbjct: 109 NVFDTNFFGAVRLVKAVLPGMKRRRQGHIVVISSVMGLQGVI-FNDV-----------YA 156

Query: 219 RSKLANILFTRELARRLEGTNVTVNVLHPGIVRT 252
            SK A   F   LA +L   N+ ++++ PG V T
Sbjct: 157 ASKFALEGFFESLAIQLLQFNIFISLVEPGPVVT 190


>gi|31542939 hydroxyprostaglandin dehydrogenase 15-(NAD) isoform 1
           [Homo sapiens]
          Length = 266

 Score = 53.5 bits (127), Expect = 3e-07
 Identities = 63/241 (26%), Positives = 102/241 (42%), Gaps = 44/241 (18%)

Query: 41  MHGKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPE 100
           ++GK  L+TGA  G+GRA A  LL  GA+V +   +     EA  Q +  L +  E  P+
Sbjct: 3   VNGKVALVTGAAQGIGRAFAEALLLKGAKVALVDWNL----EAGVQCKAALDEQFE--PQ 56

Query: 101 PGVSGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYMKTEDGFEMQ 160
                  + +  + D+A  + +R   ++++    RLD+L+NNAG+        E  +E  
Sbjct: 57  -------KTLFIQCDVADQQQLRDTFRKVVDHFGRLDILVNNAGV------NNEKNWEKT 103

Query: 161 FGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYSRS 220
             +N +     T L L  +         ++         IN   L       +   Y  S
Sbjct: 104 LQINLVSVISGTYLGLDYMSKQNGGEGGII---------INMSSLAGLMPVAQQPVYCAS 154

Query: 221 KLANILFTRE--LARRLEGTNVTVNVLHPGIVRT----------NLGRHI----HIPLLV 264
           K   + FTR   LA  L  + V +N + PG V T          N+G++I    HI  ++
Sbjct: 155 KHGIVGFTRSAALAANLMNSGVRLNAICPGFVNTAILESIEKEENMGQYIEYKDHIKDMI 214

Query: 265 K 265
           K
Sbjct: 215 K 215


>gi|50726952 retinol dehydrogenase 5 (11-cis and 9-cis) [Homo
           sapiens]
          Length = 318

 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 60/213 (28%), Positives = 94/213 (44%), Gaps = 39/213 (18%)

Query: 46  VLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPGVSG 105
           V ITG +SG GR  A +L + G RV+  C   + AE        +L++ A          
Sbjct: 31  VFITGCDSGFGRLLALQLDQRGFRVLASCLTPSGAE--------DLQRVAS--------- 73

Query: 106 VGELIVRELDLASLRSVRAFCQ--EMLQEEPRLDVLINNAG----IFQCPYMKTEDGFEM 159
              L    LD+   +SV+   +  EM  +E  L  L+NNAG    I   P++ T D F+ 
Sbjct: 74  -SRLHTTLLDITDPQSVQQAAKWVEMHVKEAGLFGLVNNAGVAGIIGPTPWL-TRDDFQR 131

Query: 160 QFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYSR 219
              VN +G   +T  LL LL+  A  R++ ++S L +             +    +C S+
Sbjct: 132 VLNVNTMGPIGVTLALLPLLQ-QARGRVINITSVLGRLA-----------ANGGGYCVSK 179

Query: 220 SKLANILFTRELARRLEGTNVTVNVLHPGIVRT 252
             L    F+  L R +    + V+++ PG  RT
Sbjct: 180 FGLE--AFSDSLRRDVAHFGIRVSIVEPGFFRT 210


>gi|210032110 hydroxysteroid (17-beta) dehydrogenase 13 isoform A
           [Homo sapiens]
          Length = 300

 Score = 52.8 bits (125), Expect = 4e-07
 Identities = 53/220 (24%), Positives = 92/220 (41%), Gaps = 32/220 (14%)

Query: 43  GKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPG 102
           G+ VLITGA  G+GR T  E  +  + +++   ++   EE A + R+            G
Sbjct: 36  GEIVLITGAGHGIGRQTTYEFAKRQSILVLWDINKRGVEETAAECRK-----------LG 84

Query: 103 VSGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAG-IFQCPYMKTED-GFEMQ 160
           V+    ++    D ++   +     ++ +E   + +++NNAG ++    + T+D      
Sbjct: 85  VTAHAYVV----DCSNREEIYRSLNQVKKEVGDVTIVVNNAGTVYPADLLSTKDEEITKT 140

Query: 161 FGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSYNKSFCYSRS 220
           F VN LGHF +T  LL  +       IV V+S            +   +       Y  S
Sbjct: 141 FEVNILGHFWITKALLPSMMERNHGHIVTVAS------------VCGHEGIPYLIPYCSS 188

Query: 221 KLANILFTRELARRLEG---TNVTVNVLHPGIVRTNLGRH 257
           K A + F R L   L+    T +  + L P  V T   ++
Sbjct: 189 KFAAVGFHRGLTSELQALGKTGIKTSCLCPVFVNTGFTKN 228


>gi|4504505 hydroxysteroid (17-beta) dehydrogenase 4 [Homo sapiens]
          Length = 736

 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 57/219 (26%), Positives = 90/219 (41%), Gaps = 33/219 (15%)

Query: 36  GDPGLMHGKTVLITGANSGLGRATAAELLRLGARVIMG-----CRDRARAEEAAGQLRRE 90
           G P    G+ VL+TGA +GLGRA A      GA V++       +   +   AA ++  E
Sbjct: 2   GSPLRFDGRVVLVTGAGAGLGRAYALAFAERGALVVVNDLGGDFKGVGKGSLAADKVVEE 61

Query: 91  LRQAAECGPEPGVSGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPY 150
           +R+             G   V   D  S+       +  L    R+DV++NNAGI +   
Sbjct: 62  IRRR------------GGKAVANYD--SVEEGEKVVKTALDAFGRIDVVVNNAGILRDRS 107

Query: 151 MK--TEDGFEMQFGVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSE 208
               +++ +++   V+  G F +T      +K     RI++ SS    YG  NF   N  
Sbjct: 108 FARISDEDWDIIHRVHLRGSFQVTRAAWEHMKKQKYGRIIMTSSASGIYG--NFGQAN-- 163

Query: 209 QSYNKSFCYSRSKLANILFTRELARRLEGTNVTVNVLHP 247
                   YS +KL  +     LA     +N+  N + P
Sbjct: 164 --------YSAAKLGLLGLANSLAIEGRKSNIHCNTIAP 194


>gi|32483357 peroxisomal short-chain alcohol dehydrogenase [Homo
           sapiens]
          Length = 278

 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 62/248 (25%), Positives = 103/248 (41%), Gaps = 37/248 (14%)

Query: 15  GALWLAARRFVGPRVQR---LRRGGDPGLMHGKTVLITGANSGLGRATAAELLRLGARVI 71
           G L L AR +   R+      RR  DP  +  K  L+T +  G+G A A  L + GA V+
Sbjct: 5   GLLGLCARAWNSVRMASSGMTRR--DP--LANKVALVTASTDGIGFAIARRLAQDGAHVV 60

Query: 72  MGCRDRARAEEAAGQLRRELRQAAECGPEPGVSGVGELIVRELDLASLRSVRAFCQEMLQ 131
           +  R +   ++A   L+ E            V  VG+   RE  +A+   +         
Sbjct: 61  VSSRKQQNVDQAVATLQGEGLSVTGT-----VCHVGKAEDRERLVATAVKLHG------- 108

Query: 132 EEPRLDVLINNAGI---FQCPYMKTEDGFEMQFGVNHLGHFLLTNLLLGLLKSSAPSRIV 188
               +D+L++NA +   F      TE+ ++    +N     L+T  ++  ++      +V
Sbjct: 109 ---GIDILVSNAAVNPFFGSIMDVTEEVWDKTLDINVKAPALMTKAVVPEMEKRGGGSVV 165

Query: 189 VVSSKLYKYGDINFDDLNSEQSYNKSFCYSRSKLANILFTRELARRLEGTNVTVNVLHPG 248
           +VSS         F              Y+ SK A +  T+ LA  L   N+ VN L PG
Sbjct: 166 IVSSIAAFSPSPGFSP------------YNVSKTALLGLTKTLAIELAPRNIRVNCLAPG 213

Query: 249 IVRTNLGR 256
           +++T+  R
Sbjct: 214 LIKTSFSR 221


>gi|109715829 short-chain dehydrogenase/reductase [Homo sapiens]
          Length = 260

 Score = 52.4 bits (124), Expect = 6e-07
 Identities = 62/259 (23%), Positives = 103/259 (39%), Gaps = 36/259 (13%)

Query: 44  KTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPEPGV 103
           +  L+TGA+ G+G A A  L++ G +V+   R     EE           AAEC      
Sbjct: 12  RLALVTGASGGIGAAVARALVQQGLKVVGCARTVGNIEEL----------AAEC---KSA 58

Query: 104 SGVGELIVRELDLASLRSVRAFCQEMLQEEPRLDVLINNAGIFQCPYM--KTEDGFEMQF 161
              G LI    DL++   + +    +  +   +D+ INNAG+ +   +   +  G++  F
Sbjct: 59  GYPGTLIPYRCDLSNEEDILSMFSAIRSQHSGVDICINNAGLARPDTLLSGSTSGWKDMF 118

Query: 162 GVNHLGHFLLTNLLLGLLKSSAPSRIVVVSSKLYKYGDINFDDLNSEQSY-----NKSFC 216
            VN             +L  S  +R    S K     D +  ++NS   +     + +  
Sbjct: 119 NVN-------------VLALSICTREAYQSMKERNVDDGHIININSMSGHRVLPLSVTHF 165

Query: 217 YSRSKLANILFTRELARRLE--GTNVTVNVLHPGIVRTNLGRHIHIPLLVKPLFNLVSWA 274
           YS +K A    T  L + L    T++    + PG+V T     +H     K         
Sbjct: 166 YSATKYAVTALTEGLRQELREAQTHIRATCISPGVVETQFAFKLHDKDPEKAAATYEQMK 225

Query: 275 FFKTPVEGAQTSIYLASSP 293
             K P + A+  IY+ S+P
Sbjct: 226 CLK-PEDVAEAVIYVLSTP 243


>gi|18860884 WW domain-containing oxidoreductase isoform 2 [Homo
           sapiens]
          Length = 189

 Score = 51.2 bits (121), Expect = 1e-06
 Identities = 26/58 (44%), Positives = 34/58 (58%)

Query: 43  GKTVLITGANSGLGRATAAELLRLGARVIMGCRDRARAEEAAGQLRRELRQAAECGPE 100
           GK V++TGANSG+G  TA      GA VI+ CR+ ARA EA  ++  E +      PE
Sbjct: 124 GKVVVVTGANSGIGFETAKSFALHGAHVILACRNMARASEAVSRILEEWKTKYHPPPE 181


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.322    0.138    0.403 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 11,906,571
Number of Sequences: 37866
Number of extensions: 496806
Number of successful extensions: 1416
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 65
Number of HSP's successfully gapped in prelim test: 16
Number of HSP's that attempted gapping in prelim test: 1281
Number of HSP's gapped (non-prelim): 88
length of query: 336
length of database: 18,247,518
effective HSP length: 103
effective length of query: 233
effective length of database: 14,347,320
effective search space: 3342925560
effective search space used: 3342925560
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 62 (28.5 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.