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Search of human proteins with 18375528
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18375528 UPF3 regulator of nonsense transcripts homolog B
isoform 1 [Homo sapiens]
(483 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|18375528 UPF3 regulator of nonsense transcripts homolog B iso... 963 0.0
gi|12711674 UPF3 regulator of nonsense transcripts homolog B iso... 928 0.0
gi|12711676 UPF3 regulator of nonsense transcripts homolog A iso... 389 e-108
gi|18375525 UPF3 regulator of nonsense transcripts homolog A iso... 323 3e-88
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 102 8e-22
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 99 9e-21
gi|148746195 trichohyalin [Homo sapiens] 97 3e-20
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 97 4e-20
gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-li... 95 1e-19
gi|239745079 PREDICTED: Putative golgin subfamily A member 6-lik... 95 2e-19
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 94 2e-19
gi|239757964 PREDICTED: hypothetical protein [Homo sapiens] 94 3e-19
gi|151301171 RNA polymerase II transcription factor TAFII140 [Ho... 94 3e-19
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 92 8e-19
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 92 1e-18
gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo sa... 92 1e-18
gi|239747891 PREDICTED: hypothetical protein [Homo sapiens] 90 5e-18
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 88 2e-17
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 88 2e-17
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 88 2e-17
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa... 85 1e-16
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 85 2e-16
gi|42560244 peptidylprolyl isomerase G [Homo sapiens] 85 2e-16
gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-li... 84 2e-16
gi|221219020 NYD-SP11 protein [Homo sapiens] 82 8e-16
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 82 1e-15
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 82 1e-15
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 82 1e-15
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 82 1e-15
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 81 2e-15
>gi|18375528 UPF3 regulator of nonsense transcripts homolog B
isoform 1 [Homo sapiens]
Length = 483
Score = 963 bits (2489), Expect = 0.0
Identities = 483/483 (100%), Positives = 483/483 (100%)
Query: 1 MKEEKEHRPKEKRVTLLTPAGATGSGGGTSGDSSKGEDKQDRNKEKKEALSKVVIRRLPP 60
MKEEKEHRPKEKRVTLLTPAGATGSGGGTSGDSSKGEDKQDRNKEKKEALSKVVIRRLPP
Sbjct: 1 MKEEKEHRPKEKRVTLLTPAGATGSGGGTSGDSSKGEDKQDRNKEKKEALSKVVIRRLPP 60
Query: 61 TLTKEQLQEHLQPMPEHDYFEFFSNDTSLYPHMYARAYINFKNQEDIILFRDRFDGYVFL 120
TLTKEQLQEHLQPMPEHDYFEFFSNDTSLYPHMYARAYINFKNQEDIILFRDRFDGYVFL
Sbjct: 61 TLTKEQLQEHLQPMPEHDYFEFFSNDTSLYPHMYARAYINFKNQEDIILFRDRFDGYVFL 120
Query: 121 DNKGQEYPAIVEFAPFQKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPET 180
DNKGQEYPAIVEFAPFQKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPET
Sbjct: 121 DNKGQEYPAIVEFAPFQKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPET 180
Query: 181 LLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEE 240
LLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEE
Sbjct: 181 LLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEE 240
Query: 241 KRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREK 300
KRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREK
Sbjct: 241 KRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREK 300
Query: 301 AKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERIL 360
AKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERIL
Sbjct: 301 AKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERIL 360
Query: 361 RERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTE 420
RERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTE
Sbjct: 361 RERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTE 420
Query: 421 KKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQESGISHRKEG 480
KKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQESGISHRKEG
Sbjct: 421 KKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQESGISHRKEG 480
Query: 481 GEE 483
GEE
Sbjct: 481 GEE 483
>gi|12711674 UPF3 regulator of nonsense transcripts homolog B
isoform 2 [Homo sapiens]
Length = 470
Score = 928 bits (2399), Expect = 0.0
Identities = 470/483 (97%), Positives = 470/483 (97%), Gaps = 13/483 (2%)
Query: 1 MKEEKEHRPKEKRVTLLTPAGATGSGGGTSGDSSKGEDKQDRNKEKKEALSKVVIRRLPP 60
MKEEKEHRPKEKRVTLLTPAGATGSGGGTSGDSSKGEDKQDRNKEKKEALSKVVIRRLPP
Sbjct: 1 MKEEKEHRPKEKRVTLLTPAGATGSGGGTSGDSSKGEDKQDRNKEKKEALSKVVIRRLPP 60
Query: 61 TLTKEQLQEHLQPMPEHDYFEFFSNDTSLYPHMYARAYINFKNQEDIILFRDRFDGYVFL 120
TLTKEQLQEHLQPMPEHDYFEFFSNDTSLYPHMYARAYINFKNQEDIILFRDRFDGYVFL
Sbjct: 61 TLTKEQLQEHLQPMPEHDYFEFFSNDTSLYPHMYARAYINFKNQEDIILFRDRFDGYVFL 120
Query: 121 DNKGQEYPAIVEFAPFQKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPET 180
DNKGQEYPAIVEFAPFQKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPET
Sbjct: 121 DNKGQEYPAIVEFAPFQKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPET 180
Query: 181 LLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEE 240
LLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEE
Sbjct: 181 LLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEE 240
Query: 241 KRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREK 300
KRKRKDIEKLKKIDRIPERDKLKDEPKIK LLKKPEKGDEKELDKREK
Sbjct: 241 KRKRKDIEKLKKIDRIPERDKLKDEPKIK-------------LLKKPEKGDEKELDKREK 287
Query: 301 AKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERIL 360
AKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERIL
Sbjct: 288 AKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERIL 347
Query: 361 RERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTE 420
RERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTE
Sbjct: 348 RERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTE 407
Query: 421 KKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQESGISHRKEG 480
KKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQESGISHRKEG
Sbjct: 408 KKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQESGISHRKEG 467
Query: 481 GEE 483
GEE
Sbjct: 468 GEE 470
>gi|12711676 UPF3 regulator of nonsense transcripts homolog A
isoform hUpf3p [Homo sapiens]
Length = 476
Score = 389 bits (999), Expect = e-108
Identities = 214/464 (46%), Positives = 302/464 (65%), Gaps = 53/464 (11%)
Query: 3 EEKEHRPKEKRVTLLTPAGATGSGGGTSGDSSKGEDKQDRNKEKKEALSKVVIRRLPPTL 62
E + HR +++ P ++G GGG G+ ++ EK+ ALSKVVIRRLPP L
Sbjct: 30 EVQFHRDSQQQEAETPPTSSSGCGGGA------GKPRE----EKRTALSKVVIRRLPPGL 79
Query: 63 TKEQLQEHLQPMPEHDYFEFFSNDTSLYPHMYARAYINFKNQEDIILFRDRFDGYVFLDN 122
TKEQL+E L+P+P HDYFEFF+ D SLYPH+Y+RAYINF+N +DI+LFRDRFDGY+FLD+
Sbjct: 80 TKEQLEEQLRPLPAHDYFEFFAADLSLYPHLYSRAYINFRNPDDILLFRDRFDGYIFLDS 139
Query: 123 KGQEYPAIVEFAPFQKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLL 182
KG EYPA+VEFAPFQK AKKK +K+D K G+I+DDPEY+KFLE+Y + EK ++ PETLL
Sbjct: 140 KGLEYPAVVEFAPFQKIAKKKLRKKDAKTGSIEDDPEYKKFLETYCVEEEKTSANPETLL 199
Query: 183 EEIEAKNRELIAKKTTPLLSFLKN----KQRMREEKREERRRREIERKRQREEERRKWKE 238
E+EAK RELIA++TTPLL ++KN KQR+REEKREERRRRE+E+KR REEE+R+ +E
Sbjct: 200 GEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRRE 259
Query: 239 EEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDK- 297
EE+ K+K+ +K KKI + E +IK LLKKPEKG+E +K
Sbjct: 260 EERCKKKETDKQKKI--------AEKEVRIK-------------LLKKPEKGEEPTTEKP 298
Query: 298 REKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQE 357
+E+ +++D E + + + + L++ P++ S + R+ ER QE
Sbjct: 299 KERGEEIDTGGGKQESCAPGAVVKARPMEGSLEE-----PQETSHSGSDKEHRDVERSQE 353
Query: 358 RILRERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKK--------AES 409
+E E + ++ RR + +E E+ +R E+E + K +D+GKK E+
Sbjct: 354 ---QESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEA 410
Query: 410 TESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLC 453
E +G +++ + +++R+ NKDRPA+QLY PGAR R R C
Sbjct: 411 MERLGRAQRCD-DSPAPRKERLANKDRPALQLYDPGARFRAREC 453
>gi|18375525 UPF3 regulator of nonsense transcripts homolog A
isoform hUpf3pdelta [Homo sapiens]
Length = 443
Score = 323 bits (827), Expect = 3e-88
Identities = 191/464 (41%), Positives = 274/464 (59%), Gaps = 86/464 (18%)
Query: 3 EEKEHRPKEKRVTLLTPAGATGSGGGTSGDSSKGEDKQDRNKEKKEALSKVVIRRLPPTL 62
E + HR +++ P ++G GGG G+ ++ EK+ ALSKVVIRRLPP L
Sbjct: 30 EVQFHRDSQQQEAETPPTSSSGCGGGA------GKPRE----EKRTALSKVVIRRLPPGL 79
Query: 63 TKEQLQEHLQPMPEHDYFEFFSNDTSLYPHMYARAYINFKNQEDIILFRDRFDGYVFLDN 122
TKEQL+E L+P+P HDYFEFF+ D SLYPH+Y+RAYINF+N +DI+LFRDRFDGY+FLD+
Sbjct: 80 TKEQLEEQLRPLPAHDYFEFFAADLSLYPHLYSRAYINFRNPDDILLFRDRFDGYIFLDS 139
Query: 123 KGQEYPAIVEFAPFQKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLL 182
K DPEY+KFLE+Y + EK ++ PETLL
Sbjct: 140 K---------------------------------DPEYKKFLETYCVEEEKTSANPETLL 166
Query: 183 EEIEAKNRELIAKKTTPLLSFLKN----KQRMREEKREERRRREIERKRQREEERRKWKE 238
E+EAK RELIA++TTPLL ++KN KQR+REEKREERRRRE+E+KR REEE+R+ +E
Sbjct: 167 GEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRRE 226
Query: 239 EEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDK- 297
EE+ K+K+ +K KKI + E +IK LLKKPEKG+E +K
Sbjct: 227 EERCKKKETDKQKKI--------AEKEVRIK-------------LLKKPEKGEEPTTEKP 265
Query: 298 REKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQE 357
+E+ +++D E + + + + L++ P++ S + R+ ER QE
Sbjct: 266 KERGEEIDTGGGKQESCAPGAVVKARPMEGSLEE-----PQETSHSGSDKEHRDVERSQE 320
Query: 358 RILRERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKK--------AES 409
+E E + ++ RR + +E E+ +R E+E + K +D+GKK E+
Sbjct: 321 ---QESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEA 377
Query: 410 TESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLC 453
E +G +++ + +++R+ NKDRPA+QLY PGAR R R C
Sbjct: 378 MERLGRAQRCD-DSPAPRKERLANKDRPALQLYDPGARFRAREC 420
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 102 bits (254), Expect = 8e-22
Identities = 81/307 (26%), Positives = 156/307 (50%), Gaps = 35/307 (11%)
Query: 205 KNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKL----------KKID 254
K++ R R+ RE +R RE ER+RQ + ER + +E+E+ ++K+ E+ ++ D
Sbjct: 85 KDRHRKRDRHRERQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTD 144
Query: 255 RIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEK-ELDKREKAKKLDKENLSDER 313
ER++ +D K + + + Q ++ E+ EK ++RE+ ++ +KEN +++R
Sbjct: 145 GQRERERQRDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDR 204
Query: 314 ASGQSCTLPKRSDSELKDEKPK---RPEDESGRDYRER----------EREYERDQERIL 360
S + + ++E + E+ + R D + RER ERE ERD+ER
Sbjct: 205 HSERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKER-E 263
Query: 361 RERERLK---RQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGK-KAESTESIGSS 416
RER+R + R+++ER RQ +R + +T + +E E K+E+ R++ + + E
Sbjct: 264 RERDRDRDRDRRQKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERER 323
Query: 417 EKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQESGISH 476
E+ +++ +RDR + ++R + + R RNR + + G AER++E
Sbjct: 324 ERERERQRETERDREKERERKRKRQTEMD-RERNR-----QTGREGRRQAERERERERER 377
Query: 477 RKEGGEE 483
++ E
Sbjct: 378 DRQSARE 384
Score = 98.2 bits (243), Expect = 1e-20
Identities = 73/283 (25%), Positives = 146/283 (51%), Gaps = 18/283 (6%)
Query: 206 NKQRMREEKREERR-RREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKD 264
+++R R+++RE RR +R+ ER+ R+ ERR +E+++ +++D + ++ DR ER++ D
Sbjct: 53 DRERNRQKERERRREKRQTERETDRKRERR--REKDRHRKRDRHRERQRDREKERERQTD 110
Query: 265 EPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDK---REKAKKLDKENLSDERASGQSCTL 321
+ + Q ++N K+ E+ E+E ++ R+ + ++E D + T
Sbjct: 111 RERDR------QREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTD 164
Query: 322 PKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEEERRRQKERYE 381
+R ++ + +R +++ ++ RERER+ E++ + R ER + +E ER + E
Sbjct: 165 RERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETER 224
Query: 382 KEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQL 441
K +T + ++ + K E R++ K+AE E E KE +RDR R++DR +
Sbjct: 225 KRQTDRERDRQRKTE----REREKQAE-RERASERETERDKERERERDRDRDRDRRQKER 279
Query: 442 YQPGARSRNRLCPPDDST-KSGDSAAERKQESGISHRKEGGEE 483
+ R R R D T + + ER++E + ++E E
Sbjct: 280 ERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERE 322
Score = 95.1 bits (235), Expect = 1e-19
Identities = 80/309 (25%), Positives = 154/309 (49%), Gaps = 27/309 (8%)
Query: 183 EEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKR 242
++ + +RE +K + +R + KRE RR ++ RKR R ER++ +E+E+
Sbjct: 47 KDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERE 106
Query: 243 KR----KDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKR 298
++ +D ++ K+ +R ER++ + + ++ + EK E++ D R
Sbjct: 107 RQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTD-R 165
Query: 299 EKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPED---ESGRDYREREREYERD 355
E+ ++ ++ N ER ++ +R + E + EK + ED E GR+ RERERE E +
Sbjct: 166 ERQRQTER-NRQKEREREKN--RQERRERERQREKENKTEDRHSERGRE-RERERETETE 221
Query: 356 QER---ILRERERLKRQEEERRRQ--KERYEKEKTFKRKEEEMKKEKDTLRDKGKKAEST 410
ER RER+R ++ E ER +Q +ER + +T + KE E ++++D RD+ +K
Sbjct: 222 TERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERER 281
Query: 411 ESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQ 470
++ ++ +++ +R R R ++R R RNR + + + ER++
Sbjct: 282 QTDRKRQRRTERDRETERKRERQRERER-------ERERNR---KRERERERERERERQR 331
Query: 471 ESGISHRKE 479
E+ KE
Sbjct: 332 ETERDREKE 340
Score = 93.2 bits (230), Expect = 5e-19
Identities = 78/312 (25%), Positives = 152/312 (48%), Gaps = 24/312 (7%)
Query: 169 TDNEKMTSTPETLLEEIEAKN-----RELIAKKTTPLLSFLKNKQRMREEKREERRRREI 223
TD E+ T +E E + RE ++ + ++ +R RE +RE E
Sbjct: 163 TDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETET 222
Query: 224 ERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVH-RFLLQAVNQKN 282
ERKRQ + ER + ++ E+ + K E+ + +R ERDK ++ + + R Q ++
Sbjct: 223 ERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQ 282
Query: 283 LLKKPEKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESG 342
+K ++ E++ RE +K +++ ER + + + E + E+ ++ E E
Sbjct: 283 TDRKRQRRTERD---RETERKRERQR---ERERERERNRKRERERERERERERQRETERD 336
Query: 343 RDY---REREREYERDQERILRERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDT 399
R+ R+R+R+ E D+ER R+ R R++ ER R++ER E+++ R+ EE ++++D
Sbjct: 337 REKERERKRKRQTEMDRERN-RQTGREGRRQAERERERER-ERDRQSAREREERERDRDR 394
Query: 400 LRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCPPDDST 459
R K ++ ++ + +TEK+ E R KDR + + + G + D
Sbjct: 395 DRQKERERQTEKDRDGQRETEKQRE-------REKDRESERGRERGREREKQKGRERDRE 447
Query: 460 KSGDSAAERKQE 471
+ D A R+++
Sbjct: 448 RQTDRQAGRQRK 459
Score = 83.6 bits (205), Expect = 4e-16
Identities = 77/327 (23%), Positives = 160/327 (48%), Gaps = 46/327 (14%)
Query: 137 QKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKK 196
Q+ + KT+ R ++ G + E + E+ T+ ++ T + E + + ++
Sbjct: 194 QREKENKTEDRHSERGR---ERERERETET-ETERKRQTDRERDRQRKTEREREKQAERE 249
Query: 197 TTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRI 256
++K+R RE R+ R R +++R+R+ +R++ ++R +D E +K +R
Sbjct: 250 RASERETERDKERERERDRDRDRDRR-QKERERQTDRKR----QRRTERDRETERKRERQ 304
Query: 257 PERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDK-REKAKKLDKENLSDERAS 315
ER++ + ++N ++ E+ E+E ++ RE + +KE ER
Sbjct: 305 RERERER----------------ERNRKRERERERERERERQRETERDREKER---ERKR 345
Query: 316 GQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEEERRR 375
+ + + + + E ++ E E R+ RER+R+ R++E R+R+R +++E ER+
Sbjct: 346 KRQTEMDRERNRQTGREGRRQAERERERE-RERDRQSAREREERERDRDRDRQKERERQT 404
Query: 376 QKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKD 435
+K+R + +T K++E E +E + R++G++ E K++ +RDR R D
Sbjct: 405 EKDRDGQRETEKQREREKDRESERGRERGRERE-------------KQKGRERDRERQTD 451
Query: 436 RPAMQLYQPGARSRNRLCPPDDSTKSG 462
R Q + RS + PP + +SG
Sbjct: 452 R---QAGRQRKRSTLYVNPPPRTARSG 475
Score = 55.8 bits (133), Expect = 8e-08
Identities = 37/146 (25%), Positives = 72/146 (49%), Gaps = 12/146 (8%)
Query: 338 EDESGRDYREREREYERDQERILRERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEK 397
+D G D RER R+ ER++ R R+ ER ++ ERRR+K+R+ K + ++ + +KE+
Sbjct: 47 KDADGDD-RERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKER 105
Query: 398 DTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCPPDD 457
+ D+ + + + ++ E++ E R+ R +DR G R R R D
Sbjct: 106 ERQTDRERDRQREKERNRQKERERETE---REGERGRDRQT-----DGQRERER---QRD 154
Query: 458 STKSGDSAAERKQESGISHRKEGGEE 483
+ K + +R+++ ++ E
Sbjct: 155 AEKERERQTDRERQRQTERNRQKERE 180
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 99.0 bits (245), Expect = 9e-21
Identities = 86/324 (26%), Positives = 144/324 (44%), Gaps = 19/324 (5%)
Query: 170 DNEKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQR 229
D + S + + K E KK K ++ E+ ER RRE ER+R+R
Sbjct: 272 DKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRERERERER 331
Query: 230 EEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEK 289
E ER K KE E+ + +D ++ DR ERD+ +D + + + K+ + EK
Sbjct: 332 EREREKEKERERERERDRDR----DRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREK 387
Query: 290 GDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESG------- 342
++E + RE+ ++ ++E + + +R KD+K R EDE
Sbjct: 388 SRDRERE-REREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERRKL 446
Query: 343 -RDYREREREY-ERDQERILRERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTL 400
R RE+E Y ER + +RER++ + E+E R++ER + ++ +E ++ D
Sbjct: 447 ERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDD 506
Query: 401 RDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCP-PDDST 459
RD K + EK+ E +RDR R K+ +L + R P PD
Sbjct: 507 RDDPKYYRGSALQKRLRDREKEMEADERDRKREKE----ELEEIRQRLLAEGHPDPDAEL 562
Query: 460 KSGDSAAERKQESGISHRKEGGEE 483
+ + AER+++ I E EE
Sbjct: 563 QRMEQEAERRRQPQIKQEPESEEE 586
Score = 95.5 bits (236), Expect = 9e-20
Identities = 77/258 (29%), Positives = 133/258 (51%), Gaps = 43/258 (16%)
Query: 184 EIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERR-----RREIERKRQREEERRKWKE 238
E+E R+LI+++ + K + + +K +ER+ RRE ER+R+RE ERR+ +E
Sbjct: 268 EMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRE-RE 326
Query: 239 EEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDK- 297
E+ + ++ EK K+ +R ERD+ +D K E++ D+
Sbjct: 327 REREREREREKEKERERERERDRDRDRTK------------------------ERDRDRD 362
Query: 298 REKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQE 357
RE+ + D+E SD R +S + K D E + E+ + E E RERERE ER++E
Sbjct: 363 RERDRDRDRERSSD-RNKDRSRSREKSRDRERERERERERERE-----RERERERERERE 416
Query: 358 RILRERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSE 417
RERER + +E++++R +E E++ +RK E +EK+ + K I +
Sbjct: 417 ---REREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLK---NWEIRERK 470
Query: 418 KTEKKEEVVKRDRIRNKD 435
KT + E+ +R+ R ++
Sbjct: 471 KTREYEKEAEREEERRRE 488
Score = 85.5 bits (210), Expect = 1e-16
Identities = 62/229 (27%), Positives = 114/229 (49%), Gaps = 28/229 (12%)
Query: 205 KNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKD 264
K++ R RE+ R+ R RE ER+R+RE ER + +E E+ + ++ E+ ++ D+ +RD+ +D
Sbjct: 379 KDRSRSREKSRDREREREREREREREREREREREREREREREREREREKDK--KRDREED 436
Query: 265 EPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKR 324
E R L + + +K + E+ E+ +R+K ++ +KE +E + KR
Sbjct: 437 EEDAYERRKLERKLREKEAAYQ-ERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKR 495
Query: 325 SDSELKDEKPKRPEDESGRD------YREREREYERDQERILRERERLK----------- 367
L+D R + + R R+RE+E E D+ RE+E L+
Sbjct: 496 LKEFLEDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGH 555
Query: 368 --------RQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAE 408
R E+E R+++ K++ +EEE K+EK+ R++ + E
Sbjct: 556 PDPDAELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEE 604
Score = 77.0 bits (188), Expect = 3e-14
Identities = 60/251 (23%), Positives = 120/251 (47%), Gaps = 43/251 (17%)
Query: 205 KNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERD---- 260
+++++ R+ +RE R RE ER+R+RE ER + +E E+ + ++ EK KK DR + +
Sbjct: 383 RSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYE 442
Query: 261 ------KLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKR----EKAKKL------ 304
KL+++ R + ++ ++ EK E+E ++R ++AK+L
Sbjct: 443 RRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLED 502
Query: 305 ---DKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYRER------------- 348
D+++ R S L R DE+ ++ E E + R+R
Sbjct: 503 YDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAEL 562
Query: 349 ---EREYERDQERILRERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGK 405
E+E ER ++ +++ + +EEE++ ++E+ E+ +EEE ++K L+ +
Sbjct: 563 QRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREE----PMEEEEEPEQKPCLKPTLR 618
Query: 406 KAESTESIGSS 416
S S+ S+
Sbjct: 619 PISSAPSVSSA 629
Score = 62.0 bits (149), Expect = 1e-09
Identities = 71/279 (25%), Positives = 116/279 (41%), Gaps = 47/279 (16%)
Query: 222 EIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQK 281
+ + K Q +E + K K R + + + E K +D+ L++ + +
Sbjct: 162 DAKTKAQLDEWKAKKKASNGNARPETVTNDDEEALDEETKRRDQMIKGAIEVLIREYSSE 221
Query: 282 NLLKKPEKGDEKELDKREKAKKLD-----------------KENLSDERASGQSCTLPKR 324
L P + + K++K KK D KE+++ L R
Sbjct: 222 --LNAPSQESDSHPRKKKKEKKEDIFRRFPVAPLIPYPLITKEDINAIEMEEDKRDLISR 279
Query: 325 SDSELKDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEEERRRQKERYEKEK 384
S+ +D K E++ ++ +E E ER + RERER +R E ER R++ER E+E
Sbjct: 280 EISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERR-ERERERERER-ERE- 336
Query: 385 TFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQP 444
K KE E ++E+D RD+ K+ ++ +E RDR R+ DR
Sbjct: 337 --KEKERERERERDRDRDRTKE---------RDRDRDRERDRDRDRERSSDRNK------ 379
Query: 445 GARSRNRLCPPDDSTKSGDSAAERKQESGISHRKEGGEE 483
RSR+R KS D ER++E +E E
Sbjct: 380 -DRSRSR-------EKSRDRERERERERERERERERERE 410
Score = 36.6 bits (83), Expect = 0.052
Identities = 42/175 (24%), Positives = 83/175 (47%), Gaps = 15/175 (8%)
Query: 94 YARAYINFKNQEDIILFRDRFDGYVFLDNKG-QEYPAIVEFAPFQKAAKKKTKKRDTK-V 151
Y R + K +E +++R + + K +EY E ++ K KR + +
Sbjct: 441 YERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFL 500
Query: 152 GTIDDDPEYRKF-----LESYATDNEKMTSTPET----LLEEIEAKNRELIAKKTTPLLS 202
DDD + K+ L+ D EK E EE+E + L+A+ +
Sbjct: 501 EDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDA 560
Query: 203 FLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIP 257
L QRM E++ E RR+ +I+++ + EEE + +E+E+++ + +E+ ++ ++ P
Sbjct: 561 EL---QRM-EQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKP 611
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 97.1 bits (240), Expect = 3e-20
Identities = 79/295 (26%), Positives = 153/295 (51%), Gaps = 46/295 (15%)
Query: 204 LKNKQRMREE---KREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERD 260
L+ +Q++R E +RE++ RRE + +R++EEER + K E++R+ + +++ ++ RD
Sbjct: 401 LRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKR----EQEERRD 456
Query: 261 KLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERASGQSCT 320
LK E + + H + +K LK+ ++E ++RE+ KL++E
Sbjct: 457 WLKREEETERH----EQERRKQQLKR-----DQEEERRERWLKLEEEE------------ 495
Query: 321 LPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEEERRRQKERY 380
+R E ++++ +R ++E +R+ E ER Q+R LR ++L+R++EERR Q +
Sbjct: 496 --RREQQERREQQLRREQEERREQRLKRQEEEERLQQR-LRSEQQLRREQEERREQLLKR 552
Query: 381 EKEKTFK--RKEEEMKKEKDTLRDKGKKAEST--------ESIGSSEKTEKKEEVVKRDR 430
E+EK + R+E+ +K+E++ RD+ K E E E+ K+EEV +R
Sbjct: 553 EEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEV---ER 609
Query: 431 IRNKDRPAMQL--YQPGARSRNRLCPPDDSTKSGDSAAERKQESGISHRKEGGEE 483
+ ++R +L +P R +L ++ + R+Q+ R + EE
Sbjct: 610 LEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEE 664
Score = 92.8 bits (229), Expect = 6e-19
Identities = 81/310 (26%), Positives = 165/310 (53%), Gaps = 26/310 (8%)
Query: 182 LEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEK 241
LEE + R + K L L+ +Q++ +E+ EE +R E E KR+R+E+ R+++EEE+
Sbjct: 878 LEEERKRRRHTLYAKPA-LQEQLRKEQQLLQEEEEELQREERE-KRRRQEQERQYREEEQ 935
Query: 242 RKRKDIEKLKKIDRIPERDKLKDEPKIKVHRF--LLQAVNQKNLLKKPEKGDEKELDKR- 298
++++ + L++ ER+K + + + + +R LQ ++ L ++PEK +E +K+
Sbjct: 936 LQQEEEQLLRE-----EREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKY 990
Query: 299 ---EKAKKLDKENLSDERASG--QSCTLPKRSDSELKDEKPKR-PEDESGRDYREREREY 352
E+ ++ +++ L +ER Q R EL+ E+ + E+ R +ERER+Y
Sbjct: 991 REEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERERQY 1050
Query: 353 ERDQERILRERERLKRQEEE--RRRQKER-YEKEKTFKRKEEEMKKEKDTLRDKGKKAES 409
R++E + +E E+L +E E RR++ ER Y KE+ +++EE++ +E+ +K ++ E
Sbjct: 1051 -REEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEP---EKRRRQER 1106
Query: 410 TESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERK 469
E+ +++EE + R+ + R ++ R + ++ + R+
Sbjct: 1107 ERQCREEEELQQEEEQLLREEREKRRRQELERQY---REEEEVQQEEEQLLREEPEKRRR 1163
Query: 470 QESGISHRKE 479
QE +R+E
Sbjct: 1164 QELERQYREE 1173
Score = 91.7 bits (226), Expect = 1e-18
Identities = 81/363 (22%), Positives = 185/363 (50%), Gaps = 37/363 (10%)
Query: 141 KKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKKTTPL 200
+++ ++R +V +++ E+RK + EK+ E++ + +L + L
Sbjct: 227 QQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQEL 286
Query: 201 LSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEE-----EKRKRKDIEKLKKIDR 255
++R EE++++R RRE + +R++EEERR+ +EE E+R++++ + +++ R
Sbjct: 287 -----RRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRR 341
Query: 256 IPE--------RDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKE 307
E R++ ++ + ++ R + ++ L ++ + E++L + ++ ++ ++
Sbjct: 342 EQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRR--EQ 399
Query: 308 NLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRERER-- 365
L E+ + L R + +L+ E+ R E E R E++ E ER ++R+ RE+E
Sbjct: 400 QLRREQQLRREQQL--RREQQLRREQQLRREQEEER--HEQKHEQERREQRLKREQEERR 455
Query: 366 --LKRQEEERRRQKERYEKEKTFKRKEEEMKKE---KDTLRDKGKKAESTESIGSSEKTE 420
LKR+EE R ++ER +++ KR +EE ++E K ++ ++ E E E+ E
Sbjct: 456 DWLKREEETERHEQER--RKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEE 513
Query: 421 KKEEVVKR----DRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQESGISH 476
++E+ +KR +R++ + R QL + R +L ++ + E++ +
Sbjct: 514 RREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEE 573
Query: 477 RKE 479
R++
Sbjct: 574 RRD 576
Score = 88.6 bits (218), Expect = 1e-17
Identities = 77/367 (20%), Positives = 182/367 (49%), Gaps = 47/367 (12%)
Query: 141 KKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKKTTPL 200
++K ++R++++ +++ +R+ E + ++ T + EE + R+ ++ + PL
Sbjct: 736 EEKRRRRESELQWQEEERAHRQQQE----EEQRRDFTWQWQAEEKSERGRQRLSARP-PL 790
Query: 201 LSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERD 260
+QR R+ + EER++RE +R EEE+ + + + + + K+++ L++ +++ R+
Sbjct: 791 -----REQRERQLRAEERQQRE-QRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRE 844
Query: 261 KLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEK-----ELDKREKAKKLDKENLSDERAS 315
+ + +++ LQ +Q+ + ++ D+K E +++ + L + E+
Sbjct: 845 RAQ---QLQEEEDGLQE-DQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLR 900
Query: 316 GQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEEERRR 375
+ L + + ++E+ KR E R YRE E+ + +++ + ERE+ +RQE ER+
Sbjct: 901 KEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQY 960
Query: 376 QKE-------------------RYEKEKTFKRKEEEMKKEKDTL----RDKGKKAESTES 412
+K+ R E+EK + R+EEE+++E++ L R+K ++ E
Sbjct: 961 RKDKKLQQKEEQLLGEEPEKRRRQEREKKY-REEEELQQEEEQLLREEREKRRRQEWERQ 1019
Query: 413 IGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQES 472
++ +++EE + R+ +++ +Q + R L ++ + R+QE
Sbjct: 1020 YRKKDELQQEEEQLLRE---EREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076
Query: 473 GISHRKE 479
+RKE
Sbjct: 1077 ERQYRKE 1083
Score = 88.2 bits (217), Expect = 2e-17
Identities = 62/260 (23%), Positives = 148/260 (56%), Gaps = 41/260 (15%)
Query: 205 KNKQRMREEKRE--------ERRRREIERKRQREEE-----RRKWKEEEKRKRKDIEKLK 251
+ +Q+ +E++RE E++ R +R RQR +E R++W+E E+R+ ++ E+L+
Sbjct: 136 RRRQKRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEE-EQLQ 194
Query: 252 KIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKG-DEKELDKREKAKKLDKENLS 310
+ E ++ DE +++ ++ LL+ KG +EK+ +RE+ ++ +E
Sbjct: 195 SC-KGHETEEFPDEEQLR----------RRELLELRRKGREEKQQQRRERQDRVFQE--E 241
Query: 311 DERASGQSCTLPKRSDSELKDEKPKRPED---------ESGRDYREREREYERDQERILR 361
+E+ + T+ ++ + +L++E+P+R + + R RER+ E Q++ LR
Sbjct: 242 EEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLR 301
Query: 362 ERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEK 421
++L+R++EE RR+++ +E+ +R+++E ++E+ R++ ++ E + + ++ E+
Sbjct: 302 REQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERRE--QQLRREQEEER 359
Query: 422 KEEVVKRDRIRNKDRPAMQL 441
+E+ ++R+ + ++R QL
Sbjct: 360 REQQLRRE--QEEERREQQL 377
Score = 87.8 bits (216), Expect = 2e-17
Identities = 78/375 (20%), Positives = 187/375 (49%), Gaps = 44/375 (11%)
Query: 136 FQKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAK 195
FQ+ +K+ +KR+T + ++ L+ ++ E L ++E + +
Sbjct: 238 FQEEEEKEWRKRETVLRKEEEK------LQEEEPQRQRELQEEEEQLRKLERQELRRERQ 291
Query: 196 KTTPLLSFLKNKQRMREEKREERR-----RREIERKRQREEERR-----KWKEE------ 239
+ L+ +Q++R ++ EERR RRE + +R+++EERR + +EE
Sbjct: 292 EEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQL 351
Query: 240 ---------EKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFL---LQAVNQKNLLKKP 287
E++ R++ E+ ++ ++ +L+ E +++ + L Q ++ L ++
Sbjct: 352 RREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 411
Query: 288 EKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYRE 347
+ E++L + ++ ++ +E +++ + + + E + + KR E+ +
Sbjct: 412 QLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERHEQER 471
Query: 348 REREYERDQERILRERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKA 407
R+++ +RDQE RER LK +EEERR Q+ER +E+ +R++EE ++++ +++ ++
Sbjct: 472 RKQQLKRDQEEERRER-WLKLEEEERREQQER--REQQLRREQEERREQRLKRQEEEERL 528
Query: 408 ES---TESIGSSEKTEKKEEVVKRDRIR--NKDRPAMQLYQPGARSRNRLCPPDDSTKSG 462
+ +E E+ E++E+++KR+ + ++R +L + R++L ++ +
Sbjct: 529 QQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERR-- 586
Query: 463 DSAAERKQESGISHR 477
+R+QE + R
Sbjct: 587 QQRLKREQEERLEQR 601
Score = 86.7 bits (213), Expect = 4e-17
Identities = 73/284 (25%), Positives = 143/284 (50%), Gaps = 22/284 (7%)
Query: 208 QRMREEKREERRRREIERKRQREEERR-KWK--EEEKRKRKDIEKLKKIDRIPERDKLKD 264
+R E +R E+ RR+ + KR +EEERR +W EEE+R+ + + +++ R E + +
Sbjct: 459 KREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQR 518
Query: 265 EPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKR 324
+ + L Q + + L++ ++ ++L KRE+ K+L++E Q +R
Sbjct: 519 LKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQE----ER 574
Query: 325 SDSELKDEKPKRP-----EDESGRDYREREREYERDQERILRERERLKRQEEERRRQKER 379
D LK E+ +R E E + R + E ER ++ RE +RLKR+E E R+++
Sbjct: 575 RDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERRE-QRLKREEPEEERRQQL 633
Query: 380 YEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRD-RIRNKDRPA 438
+ E+ +R+++++++E+ R++ K E E+ E+ E+ +KR+ +++
Sbjct: 634 LKSEEQEERRQQQLRREQQERREQRLKRE--------EEEERLEQRLKREHEEERREQEL 685
Query: 439 MQLYQPGARSRNRLCPPDDSTKSGDSAAERKQESGISHRKEGGE 482
+ Q AR R + P + A R+ + RK+ G+
Sbjct: 686 AEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQ 729
Score = 86.7 bits (213), Expect = 4e-17
Identities = 60/238 (25%), Positives = 131/238 (55%), Gaps = 16/238 (6%)
Query: 205 KNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKD 264
+ KQ+++ ++ EERR R ++ + + E+++ +E++ R+ ++ + +++ R E ++L+
Sbjct: 471 RRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQ 530
Query: 265 EPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKR 324
+ + Q ++ LLK+ E EK L++ + ++L +E +ER +R
Sbjct: 531 RLRSEQQLRREQEERREQLLKREE---EKRLEQERREQRLKREQ--EERRDQLLKREEER 585
Query: 325 SDSELKDEKPKRPEDESGRDYREREREYERDQERILRE-------RERLKRQEEERRRQK 377
LK E+ +R E R+ ER + ER ++R+ RE ++ LK +E+E RRQ+
Sbjct: 586 RQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQ 645
Query: 378 ERYEKEKTFKRKEEEMKKEKDTLR-DKGKKAESTESIGSSEKTEKKEEVVKRDRIRNK 434
+ +++ +R+E+ +K+E++ R ++ K E E E E+++E R+RI+++
Sbjct: 646 QLRREQQ--ERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQA-RERIKSR 700
Score = 85.1 bits (209), Expect = 1e-16
Identities = 53/242 (21%), Positives = 135/242 (55%), Gaps = 16/242 (6%)
Query: 207 KQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKD-- 264
+QR ++REERR E + + + E ++ +EE+ +R+++ +L++ R ++ + ++
Sbjct: 175 RQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQ 234
Query: 265 --------EPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERASG 316
E + + +L+ +K ++P++ E + ++ E+ +KL+++ L ER
Sbjct: 235 DRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQ-EEEEQLRKLERQELRRERQEE 293
Query: 317 QSCTLPKRSDSEL--KDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEEERR 374
+ R + +L K E+ +R + E R+ +ER + E +E+ LR RE+ +R+E++ R
Sbjct: 294 EQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLR-REQEERREQQLR 352
Query: 375 RQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNK 434
R++E +E+ +R++EE ++E+ R++ + E + + ++ +++++ + ++R +
Sbjct: 353 REQEEERREQQLRREQEEERREQQLRREQQLRRE--QQLRREQQLRREQQLRREQQLRRE 410
Query: 435 DR 436
+
Sbjct: 411 QQ 412
Score = 84.7 bits (208), Expect = 2e-16
Identities = 62/248 (25%), Positives = 144/248 (58%), Gaps = 23/248 (9%)
Query: 204 LKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLK 263
L+ +++ REEK+++RR R+ +R Q EEE+ +W++ E RK+ EKL++ + +R+ +
Sbjct: 216 LELRRKGREEKQQQRRERQ-DRVFQEEEEK-EWRKRETVLRKEEEKLQEEEPQRQRELQE 273
Query: 264 DEPKIK------VHRFLLQAVNQKNLLKKPEKGDEKELDKR-----EKAKKLDKENLSDE 312
+E +++ + R + Q+ L++ ++ K+ ++R E+ ++ ++ +E
Sbjct: 274 EEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEE 333
Query: 313 RASGQSCTLPKRSDSELKDEKPKRPEDESGRDYR-EREREYERDQERILRERERLKRQEE 371
R Q +R E ++++ +R ++E R+ + RE+E ER +E+ LR ++L+R+++
Sbjct: 334 RREQQL----RREQEERREQQLRREQEEERREQQLRREQEEER-REQQLRREQQLRREQQ 388
Query: 372 ERRRQKERYEKE---KTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSE-KTEKKEEVVK 427
RR Q+ R E++ + R+E+++++E+ R++ + E E + + E++E+ +K
Sbjct: 389 LRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLK 448
Query: 428 RDRIRNKD 435
R++ +D
Sbjct: 449 REQEERRD 456
Score = 82.0 bits (201), Expect = 1e-15
Identities = 75/292 (25%), Positives = 144/292 (49%), Gaps = 38/292 (13%)
Query: 183 EEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIER------KRQREEERRKW 236
EE E + R+ ++ + ++++ E+RE+RRR+E ER K Q++EE+
Sbjct: 916 EEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQLLG 975
Query: 237 KEEEKRKRKDIEKLKKIDRI--PERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKE 294
+E EKR+R++ EK + + E ++L E + K R Q ++ K + +E++
Sbjct: 976 EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRR---QEWERQYRKKDELQQEEEQ 1032
Query: 295 LDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYER 354
L + E+ K+ +E ER + L + + L +E+ R E R YR +E E ++
Sbjct: 1033 LLREEREKRRLQER---ERQYREEEELQQEEEQLLGEERETRRRQELERQYR-KEEELQQ 1088
Query: 355 DQERILRE---------RERLKRQEE-----------ERRRQKERYEKEKTFKRKEEEMK 394
++E++LRE RER R+EE E R ++ R E E+ ++ +EE +
Sbjct: 1089 EEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQ 1148
Query: 395 KEKDTLR---DKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQ 443
+E+ LR +K ++ E E+ +++EE + R+ + + + Y+
Sbjct: 1149 EEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYR 1200
Score = 81.6 bits (200), Expect = 1e-15
Identities = 74/362 (20%), Positives = 171/362 (47%), Gaps = 29/362 (8%)
Query: 136 FQKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAK 195
+Q +K+ RD KV + E + LE + + + LL E + ++RE +
Sbjct: 1225 WQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERR 1284
Query: 196 KTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDR 255
+ ++++ E+++E +RR +RK Q E++ + + EEKR+R++ ++ +
Sbjct: 1285 RWQQRDRHFPEEEQLEREEQKEAKRR--DRKSQEEKQLLREEREEKRRRQETDRKFR--- 1339
Query: 256 IPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKG-----DEKELDKREKAKKLDKENLS 310
E L++ + + R ++ L+ E+G +E+ L ++E+ +K KE
Sbjct: 1340 -EEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEE-Q 1397
Query: 311 DERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYR---------EREREYERDQERILR 361
R + L + D + ++E+ + E R +R ERER++ +++++ +
Sbjct: 1398 QLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQ 1457
Query: 362 ERERLKRQEEERRRQKE-----RYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSS 416
ER R R+EE+ +++E R E+++ F +E+++++++ RD+ + + S
Sbjct: 1458 ERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQE---RDRKFREQELRSQEPE 1514
Query: 417 EKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQESGISH 476
K ++E+ + R + + K Q + R + R D + + + ++E +S
Sbjct: 1515 RKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSR 1574
Query: 477 RK 478
++
Sbjct: 1575 QE 1576
Score = 80.9 bits (198), Expect = 2e-15
Identities = 87/393 (22%), Positives = 184/393 (46%), Gaps = 58/393 (14%)
Query: 137 QKAAKKKTKKRDTKVGTIDDDPEYRKFLE---SYATDNEKMTSTPETLLEEIEAKNRELI 193
++ +K K + + + ++PE R+ E Y + E + L EE E + R+
Sbjct: 957 ERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEW 1016
Query: 194 AKKTTPLLSFLKNKQRMREEKREERRRREIERKR------QREEERRKWKEEEKRKRKDI 247
++ + ++++ E+RE+RR +E ER+ Q+EEE+ +E E R+R+++
Sbjct: 1017 ERQYRKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQEL 1076
Query: 248 EK-LKKIDRIPERDK--LKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKL 304
E+ +K + + + ++ L++EP+ + + ++ ++ E E+E RE+ +K
Sbjct: 1077 ERQYRKEEELQQEEEQLLREEPEKRRRQ-----ERERQCREEEELQQEEEQLLREEREKR 1131
Query: 305 DKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRER- 363
++ L ER + + + + L++E KR E R YRE E E ++++E++LRE
Sbjct: 1132 RRQEL--ERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEE-ELQQEEEQLLREEQ 1188
Query: 364 --------------ERLKRQEEERRRQKE----------RYEKEKTFK--------RKEE 391
E L+RQ+ ++R + E EKE + R+ E
Sbjct: 1189 EKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENE 1248
Query: 392 EMKKEKDT-LRDKGKKAESTESIGSSEKTEKKEE---VVKRDRIRNKDRPAMQLYQPGAR 447
+ ++ +D+ LRD+ + + +G ++ ++++E +RDR ++ + Q A+
Sbjct: 1249 QFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAK 1308
Query: 448 SRNRLCPPDDS-TKSGDSAAERKQESGISHRKE 479
R+R + + R+QE+ R+E
Sbjct: 1309 RRDRKSQEEKQLLREEREEKRRRQETDRKFREE 1341
Score = 80.9 bits (198), Expect = 2e-15
Identities = 57/236 (24%), Positives = 129/236 (54%), Gaps = 29/236 (12%)
Query: 207 KQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKDEP 266
+Q++R ++R+ + R E ++ R++E ER+ +EE++ +R+++E+ + E ++L+ E
Sbjct: 1681 EQQLRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELER-----KFREEEQLRQET 1735
Query: 267 KIKVHRFLLQAVNQKNLLK----KPEKGDEKELDKREKAKKL-DKENLSDERAS----GQ 317
+ L + + +L+ +PE+ +E++L ++E+ +K ++E L ER Q
Sbjct: 1736 E---QEQLRRQERYRKILEEEQLRPER-EEQQLRRQERDRKFREEEQLRQEREEQQLRSQ 1791
Query: 318 SCTLPKRSDSELKDEKPK---RPEDESGR-DYREREREYERDQERILRERERLKRQEEE- 372
R + +L+ E+ + RP+ G+ + E + + E ++R+ +ER+R R EE+
Sbjct: 1792 ESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQF 1851
Query: 373 ------RRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKK 422
RR ++E +++E+ +R+E E K ++ +R + K+ + +G + E K
Sbjct: 1852 ATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGK 1907
Score = 79.7 bits (195), Expect = 5e-15
Identities = 76/350 (21%), Positives = 176/350 (50%), Gaps = 49/350 (14%)
Query: 121 DNKGQEYPAIVEFAPFQKAAKKKTKKRDTKVGTIDDDPEY---------RKFLESYATDN 171
D K QE ++ +K +++T ++ + + + E RKF E
Sbjct: 1311 DRKSQEEKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQ 1370
Query: 172 EKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREE 231
E+ LEE + R+ +K FLK +Q++R ++RE++ R++ +RK + EE
Sbjct: 1371 EQ----GRKFLEEEQRLRRQERERK------FLKEEQQLRCQEREQQLRQDRDRKFREEE 1420
Query: 232 ERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGD 291
++ +E +++ R++ +++++ +R ER L++E +++ R + ++ LL++ E
Sbjct: 1421 QQLSRQERDRKFREEEQQVRRQER--ERKFLEEEQQLRQERHR-KFREEEQLLQERE--- 1474
Query: 292 EKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRP----EDESGRDYRE 347
E++L ++E+ D++ L +E+ + K + EL+ ++P+R E + R R+
Sbjct: 1475 EQQLHRQER----DRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQ 1530
Query: 348 R------------EREYER--DQERILRERERLKRQEEERRRQKERYEKEKTFKRKEEEM 393
R ER +R D++R RE E+L+++ EE +Q R E+++ F+ +E+++
Sbjct: 1531 RKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREE--QQLSRQERDRKFRLEEQKV 1588
Query: 394 KKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQ 443
++++ + + + G + ++++ + D ++R QL++
Sbjct: 1589 RRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHR 1638
Score = 78.6 bits (192), Expect = 1e-14
Identities = 72/292 (24%), Positives = 150/292 (51%), Gaps = 26/292 (8%)
Query: 161 RKFLESYATDNEKMTSTPETLL-EEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERR 219
R+ LE E++ E LL EE E + R+ ++ + ++++ E+RE+RR
Sbjct: 1073 RQELERQYRKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREEREKRR 1132
Query: 220 RREIERKRQREEERRKWKEE------EKRKRKDIEKLKKIDRIPERDK---LKDEPKIKV 270
R+E+ER+ + EEE ++ +E+ EKR+R+++E+ + + ++++ L++E + +
Sbjct: 1133 RQELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRR 1192
Query: 271 HRFLLQAVNQKNLLKKPEKGDEKELDKREKAK---KLDKEN-LSDERA---SGQSCTLPK 323
Q ++ L ++ K ++ D+R K + +KEN + D + ++ +
Sbjct: 1193 QERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQ 1252
Query: 324 RSDSELKDEKPKRPEDESGRDYREREREYER----DQERILRERERLKRQEE-ERRRQKE 378
DS+L+D + ++ + +ER+RE ER ++R E E+L+R+E+ E +R+
Sbjct: 1253 LEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDR 1312
Query: 379 RYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDR 430
+ ++EK R+E E K+ + K ++ E E+ E+ +RDR
Sbjct: 1313 KSQEEKQLLREEREEKRRRQETDRKFREEEQL----LQEREEQPLRRQERDR 1360
Score = 77.0 bits (188), Expect = 3e-14
Identities = 72/290 (24%), Positives = 146/290 (50%), Gaps = 53/290 (18%)
Query: 203 FLKNKQRMREEKREERRRREI------ERKRQREEERRKWKEEEKRKRKDIEKLKKI--- 253
FL+ +Q++R+E+ + R E E++ R+E RK+ EEE++ R+ E+ +K
Sbjct: 1448 FLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQQLRRQ-ERDRKFREQ 1506
Query: 254 ---DRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLS 310
+ PER L++E ++ + + + ++ L++ E+G ++ D+ K + ++E L
Sbjct: 1507 ELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFR--EEEQLR 1564
Query: 311 DERASGQSCTLPKRSDSELKDEKPKRPEDE-------------SGRDY--REREREYERD 355
ER Q + L+++K +R E E G+ +ER+R++ R+
Sbjct: 1565 QEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKF-RE 1623
Query: 356 QERILRERE--RLKRQEEER-------------RRQKERYEKEKTFKRKEEEMKK-EKDT 399
E++L+ERE +L RQE +R R Q+ R+++++ F+ +E+ +++ E+
Sbjct: 1624 DEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQ 1683
Query: 400 LR--DKGKKAESTESIGSSEKTEKK----EEVVKRDRIRNKDRPAMQLYQ 443
LR ++ +K E ++ E+K E+ ++R + K R QL Q
Sbjct: 1684 LRRQERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQ 1733
Score = 75.9 bits (185), Expect = 8e-14
Identities = 60/247 (24%), Positives = 125/247 (50%), Gaps = 24/247 (9%)
Query: 205 KNKQRMREEKREERRRREIERKRQREEER-----------RKWKEEEKRKRKDIEKLKKI 253
+ ++R ++ +RE+ RRE KRQ EEER R+ +EE + + E+ K++
Sbjct: 499 QQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRL 558
Query: 254 DRIPERDKLKDEPKIKVHRFLLQAVN--QKNLLKKPEKGDEKELDKREKAKKLDKENLSD 311
++ +LK E + + + L + Q+ L ++ E+ E+ L KRE+ ++L++E +
Sbjct: 559 EQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRL-KREEVERLEQEERRE 617
Query: 312 ERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEE 371
+R + +R +E+ +R + + R+ +ER + + +E R +RLKR+ E
Sbjct: 618 QRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHE 677
Query: 372 ERRRQKERYEKEKTFKRK---------EEEMKKEKDTLRDKGKKAESTESIGSSEKTEKK 422
E RR++E E+E+ R+ + +++ E D + K + + G + E++
Sbjct: 678 EERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSK-VYSRPRKQEGQRRRQEQE 736
Query: 423 EEVVKRD 429
E+ +R+
Sbjct: 737 EKRRRRE 743
Score = 75.1 bits (183), Expect = 1e-13
Identities = 82/376 (21%), Positives = 182/376 (48%), Gaps = 40/376 (10%)
Query: 137 QKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKK 196
Q+ +++ ++RD + ++ + R E +++ LE+ E + + L K+
Sbjct: 565 QRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRL--KR 622
Query: 197 TTPLLSFLKNKQRMREEKREERRRREIERKRQ-REEERRKWKEEEKRKRKDIEKLKKIDR 255
P + +Q ++ E++EERR++++ R++Q R E+R K +EEE+R + +++ + +R
Sbjct: 623 EEPEEE--RRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEER 680
Query: 256 IP------ERDKLKDEPKIKVHRFLLQA-----VNQKNLLKKPEK--GDEKELDKREKAK 302
E+++ ++ K ++ ++ Q Q + +P K G + ++ EK +
Sbjct: 681 REQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRR 740
Query: 303 KLDKENL--SDERASGQSCTLPKRSD------SELKDEKPK-----RPEDESGRDYRERE 349
+ + E +ERA Q +R D +E K E+ + RP R+ + R
Sbjct: 741 RRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRA 800
Query: 350 REYERDQERILRERE----RLKRQEEERRRQKERYEKEKTFKRKE--EEMKKEKDTLRDK 403
E ++ ++R L E E R +++ ER ++ + E+E+ +R+E +++++E+D L++
Sbjct: 801 EERQQREQRFLPEEEEKEQRRRQR-REREKELQFLEEEEQLQRRERAQQLQEEEDGLQED 859
Query: 404 GKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGD 463
++ S E + + EE KR R +PA+Q + + + L ++ + +
Sbjct: 860 QERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQ--EQLRKEQQLLQEEEEELQREE 917
Query: 464 SAAERKQESGISHRKE 479
R+QE +R+E
Sbjct: 918 REKRRRQEQERQYREE 933
Score = 74.7 bits (182), Expect = 2e-13
Identities = 70/345 (20%), Positives = 174/345 (50%), Gaps = 44/345 (12%)
Query: 141 KKKTKKRDTKVGTIDDDPEYRKF--LESYATDNEKMTSTPETLLEEIEAKNRELIAKKTT 198
++K ++++ + ++D+ + R+ + + ++ E LL+E E + +
Sbjct: 1585 EQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDR- 1643
Query: 199 PLLSFLKNKQRMREEKREERRRREIERK--------RQREEERRKWKEEEKRKRKDIEKL 250
FL+ + ++R ++RE++ R + +RK ++ EE++ + +E +++ R++ ++L
Sbjct: 1644 ---KFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQL 1700
Query: 251 KKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKK-LDKENL 309
++ +R ER L++E +++ + ++ L ++ E +++L ++E+ +K L++E L
Sbjct: 1701 RRQER--ERKFLQEEQQLRRQELERKFREEEQLRQETE---QEQLRRQERYRKILEEEQL 1755
Query: 310 SDERASGQSCTLPK----RSDSELKDEKPKRP--EDESGRDYRE-------REREYERDQ 356
ER Q + R + +L+ E+ ++ ES R +RE RE + R Q
Sbjct: 1756 RPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQ 1815
Query: 357 ERILR---ERERLKRQEEERRRQKER---YEKEKTFKRKEEEMKKEKDTLRDKGKKAEST 410
+R + E E+L+ +E+E+R ++ER Y E+ F +E+ ++E++ +++ +K
Sbjct: 1816 QRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQ- 1874
Query: 411 ESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCPP 455
E+ ++E + ++ + + R ++ + RL P
Sbjct: 1875 ----ERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEP 1915
Score = 72.4 bits (176), Expect = 9e-13
Identities = 60/290 (20%), Positives = 145/290 (50%), Gaps = 22/290 (7%)
Query: 203 FLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKL 262
F + +Q++ ++R+ + R E ++ R++E ER+ +EE++ +++ K ++ +++ + +
Sbjct: 1416 FREEEQQLSRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREE 1475
Query: 263 KDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERASGQSCTLP 322
+ + + R L+ Q ++ K E+EL +E +K +E Q
Sbjct: 1476 QQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEE--------QQLHRQ 1527
Query: 323 KRSDSELKDEKPKRPEDESGRDYREREREY-ERDQERILRERERLKRQEEERRRQKE--- 378
+R L++E+ R ++ + ++R+R++ E +Q R RE ++L RQE +R+ + E
Sbjct: 1528 QRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQK 1587
Query: 379 --RYEKEKTFKRKEEEMKK---EKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRN 433
R E+E+ F E+++++ ++ +++ +K E + E+ E++ +RDR
Sbjct: 1588 VRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQL-LQEREEQQLHRQERDRKFL 1646
Query: 434 KDRPAMQLYQPGARSRN----RLCPPDDSTKSGDSAAERKQESGISHRKE 479
++ P ++ + + R+ + + + G+ R+QE R+E
Sbjct: 1647 EEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREE 1696
Score = 71.2 bits (173), Expect = 2e-12
Identities = 56/256 (21%), Positives = 143/256 (55%), Gaps = 24/256 (9%)
Query: 182 LEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEK 241
LEE + + +E K F++++Q++R ++ +++ R+E +RK + +E+ + +EE++
Sbjct: 1583 LEEQKVRRQEQERK-------FMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQ 1635
Query: 242 RKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKA 301
R++ ++ K ++ P+ + + E +++ H + ++ LL ++G+E++L ++E+
Sbjct: 1636 LHRQERDR-KFLEEEPQLRRQEREQQLR-HDRDRKFREEEQLL---QEGEEQQLRRQERD 1690
Query: 302 KKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILR 361
+K +E R + L + ++ + K E+E R E+E+ +++ R +
Sbjct: 1691 RKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKIL 1750
Query: 362 ERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEK 421
E E+L+ + EE +Q R E+++ F R+EE++++E++ + + ++ S++ +
Sbjct: 1751 EEEQLRPEREE--QQLRRQERDRKF-REEEQLRQEREEQQLRSQE---------SDRKFR 1798
Query: 422 KEEVVKRDRIRNKDRP 437
+EE ++++R + RP
Sbjct: 1799 EEEQLRQEREEQQLRP 1814
Score = 69.7 bits (169), Expect = 6e-12
Identities = 79/358 (22%), Positives = 164/358 (45%), Gaps = 43/358 (12%)
Query: 137 QKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKK 196
++ +K+ KRD ++ ++L+ + + E L + + RE K+
Sbjct: 468 EQERRKQQLKRD------QEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKR 521
Query: 197 TTP---LLSFLKNKQRMR---EEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKL 250
L L+++Q++R EE+RE+ +RE E++ ++E ++ K E++ +R + K
Sbjct: 522 QEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKR 581
Query: 251 KKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLS 310
++ +R +R K + E +++ R + V + ++ E+ ++E + E+ ++L K
Sbjct: 582 EE-ERRQQRLKREQEERLE-QRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQ 639
Query: 311 DERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERD-QERILRERERLKRQ 369
+ER Q +R E ++++ KR E+E + R + RE+E + +E+ L E E Q
Sbjct: 640 EERRQQQL----RREQQERREQRLKREEEEERLEQRLK-REHEEERREQELAEEE----Q 690
Query: 370 EEERRRQKERYEK-------------EKTFKR-KEEEMKKEKDTLRDKGKKAESTESIGS 415
E+ R R K R K K + R +++E ++ + +K ++ ES
Sbjct: 691 EQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQE 750
Query: 416 SEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLC--PPDDSTKSGDSAAERKQE 471
E+ ++++ + R Q + R R RL PP + AE +Q+
Sbjct: 751 EERAHRQQQ---EEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQ 805
Score = 63.9 bits (154), Expect = 3e-10
Identities = 62/256 (24%), Positives = 123/256 (48%), Gaps = 24/256 (9%)
Query: 238 EEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKG-----DE 292
+EEKR R D ++ DR E D+ + EP+ R L + Q+ K+ E+ E
Sbjct: 96 DEEKRARCDGKESLLQDRRQEEDQRRFEPR---DRQLEEEPGQRRRQKRQEQERELAEGE 152
Query: 293 KELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREY 352
++ +K+E+ ++ D++ +E R E ++ + +R E+E + + E E
Sbjct: 153 EQSEKQERLEQRDRQRRDEELW---------RQRQEWQEREERRAEEEQLQSCKGHETEE 203
Query: 353 ERDQERILRERERL---KRQEEERRRQKERYEKEKTFKRKEE-EMKKEKDTLRDKGKKAE 408
D+E+ LR RE L ++ EE+++Q+ R +++ F+ +EE E +K + LR + +K +
Sbjct: 204 FPDEEQ-LRRRELLELRRKGREEKQQQR-RERQDRVFQEEEEKEWRKRETVLRKEEEKLQ 261
Query: 409 STESIGSSEKTEKKEEVVKRDRIR-NKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAE 467
E E E++E++ K +R ++R + Q R +L + +
Sbjct: 262 EEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER 321
Query: 468 RKQESGISHRKEGGEE 483
R+Q+ ++E E+
Sbjct: 322 REQQERREQQEERREQ 337
Score = 63.5 bits (153), Expect = 4e-10
Identities = 69/309 (22%), Positives = 150/309 (48%), Gaps = 40/309 (12%)
Query: 145 KKRDTKVGTIDDDPEYRKFL--ESYATDNEKMTSTPETLLEEIEAKNRELIAKKTTPLLS 202
++RD K ++++P+ R+ + D ++ E LL+E E + ++
Sbjct: 1639 QERDRKF--LEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQ----LRRQERDRK 1692
Query: 203 FLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKL 262
F + +Q++R ++RE + +E ++ R++E ER+ +EE+ R+ + E+L++ +R K+
Sbjct: 1693 FREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYR---KI 1749
Query: 263 KDEPKIKVHRFLLQAVNQKNLLKKPEKG------DEKELDKREKAKKL-DKENLSDERAS 315
+E +++ R Q Q+ K E+ +E++L +E +K ++E L ER
Sbjct: 1750 LEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREE 1809
Query: 316 GQSCTLPKRSDSELK-DEKPKRPEDESGRDYREREREYE------------RDQERILRE 362
Q P++ D + + +E+ + E++ R +ER+R+Y R+++ + +E
Sbjct: 1810 QQ--LRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQE 1867
Query: 363 RERLKRQEEE-------RRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGS 415
E+ +RQE E RRQ++ ++ + + + K L + G ++ + S
Sbjct: 1868 EEQKRRQERERKLREEHIRRQQKEEQRHRQVGEIKSQEGKGHGRLLEPGTHQFASVPVRS 1927
Query: 416 SEKTEKKEE 424
S E +E
Sbjct: 1928 SPLYEYIQE 1936
Score = 46.2 bits (108), Expect = 7e-05
Identities = 38/177 (21%), Positives = 86/177 (48%), Gaps = 23/177 (12%)
Query: 290 GDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYRE-R 348
G LD+ ++A+ KE+L +R + + D +L++E +R + RE
Sbjct: 90 GQATGLDEEKRARCDGKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELA 149
Query: 349 EREYERDQERILRERERLKRQEEERRRQKERYEKEKTFKRKEEEM--------------- 393
E E + +++ L +R+R +R++EE RQ++ +++ + + +EE++
Sbjct: 150 EGEEQSEKQERLEQRDR-QRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEE 208
Query: 394 ---KKEKDTLRDKGKKAESTESIGSSEKT---EKKEEVVKRDRIRNKDRPAMQLYQP 444
++E LR KG++ + + ++ E+++E KR+ + K+ +Q +P
Sbjct: 209 QLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEP 265
Score = 32.0 bits (71), Expect = 1.3
Identities = 34/184 (18%), Positives = 81/184 (44%), Gaps = 21/184 (11%)
Query: 317 QSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEEERR-- 374
Q+C + L +EK R + G++ ++R E DQ R +L+ + +RR
Sbjct: 83 QACYYALGQATGLDEEKRARCD---GKESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQ 139
Query: 375 -RQKERYE--------------KEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKT 419
RQ++ E +++ +R++EE+ +++ +++ ++ E + S K
Sbjct: 140 KRQEQERELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSC-KG 198
Query: 420 EKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQESGISHRKE 479
+ EE +++R ++ ++ + + R D + + RK+E+ + +E
Sbjct: 199 HETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEE 258
Query: 480 GGEE 483
+E
Sbjct: 259 KLQE 262
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 96.7 bits (239), Expect = 4e-20
Identities = 70/228 (30%), Positives = 125/228 (54%), Gaps = 24/228 (10%)
Query: 202 SFLKNKQRMREEKREERRRREIERKRQR-EEERRKWKEEEKRKRKDIEKLKKIDRIPERD 260
S ++ ++R E ++E ++ RE ERK++R E E+RK + E++RKR+ +K KK +R E
Sbjct: 36 SEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEER 95
Query: 261 KLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLS---DERASGQ 317
+ K ++ K+ ++G+EKE KR+K +K ++ S ER +
Sbjct: 96 ERK----------------KRRREKENKEGEEKE--KRKKKEKKERGRTSKEGKERERKE 137
Query: 318 SCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRER-ERLKRQEEERRRQ 376
+R + E K E+ ++ + R RER++ E+++ER +ER ER KR+ + R+
Sbjct: 138 ERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERK 197
Query: 377 KERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTE-SIGSSEKTEKKE 423
KER KE+ ++KE + K+E+ R K ++ E G E+ E+K+
Sbjct: 198 KERERKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245
Score = 89.4 bits (220), Expect = 7e-18
Identities = 62/230 (26%), Positives = 115/230 (50%), Gaps = 46/230 (20%)
Query: 207 KQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKDEP 266
+ +RE +RE R+E K++RE ER+K + E ++++++ EK +K +R
Sbjct: 35 QSEIREREREIETRKE--GKKERESERKKERREREKRKREREKERKRERG---------- 82
Query: 267 KIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSD 326
KK +KG+ K+ ++ K ++ +KEN E +
Sbjct: 83 ------------------KKEKKGERKKEERERKKRRREKENKEGE-------------E 111
Query: 327 SELKDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEEERRRQKERYEKEKTF 386
E + +K K+ + ++ +ERER+ ER +E +ERER K + E+ R +KER ++E+
Sbjct: 112 KEKRKKKEKKERGRTSKEGKERERKEERKREE-RKERERKKEEREKERERKERKKRERKQ 170
Query: 387 KRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDR 436
++EE +KEK+ R + KK E E+ K+ K++R + ++R
Sbjct: 171 VGEKEEERKEKE--RKERKKRERNRKERKKERERKERRERKKERKKKEER 218
Score = 78.2 bits (191), Expect = 2e-14
Identities = 63/220 (28%), Positives = 115/220 (52%), Gaps = 25/220 (11%)
Query: 184 EIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRK 243
EI + RE+ +K K+R E K+E R R + +R+R++E +R + K+E+K +
Sbjct: 37 EIREREREIETRKEG-------KKERESERKKERREREKRKREREKERKRERGKKEKKGE 89
Query: 244 RKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKK 303
RK E+ +K R R+K E + K R + + K+ ++ + KE KRE+ K+
Sbjct: 90 RKKEERERKKRR---REKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKE 146
Query: 304 LD-------KENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREY---- 352
+ KE ER + + ++ + + E+ +R + E R R++ERE
Sbjct: 147 RERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKERR 206
Query: 353 ERDQERILRERERLKRQEEERR---RQKERYEKEKTFKRK 389
ER +ER +E ER K ++++R+ R+KER ++E+ ++K
Sbjct: 207 ERKKERKKKE-ERKKERQKDRQTNWREKERGKRERKERKK 245
Score = 70.9 bits (172), Expect = 2e-12
Identities = 61/212 (28%), Positives = 106/212 (50%), Gaps = 20/212 (9%)
Query: 275 LQAVNQKNLLKK-PEKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEK 333
LQ V+ ++ K + G + E+ +RE+ + KE K +SE K E+
Sbjct: 17 LQMVSCSHISKPCTQPGWQSEIREREREIETRKEG-------------KKERESERKKER 63
Query: 334 PKRPEDESGRDYREREREYERDQERILRERERLKRQEEERRRQKERYEKEKTFKRKEEEM 393
+R E + RE+ER+ ER ++ ER++ +R+ ++RRR+KE E E+ KRK++E
Sbjct: 64 RER---EKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKE- 119
Query: 394 KKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIR-NKDRPAMQLYQPGARSRNRL 452
KKE+ +GK+ E E E+ E++ + +R++ R K+R + Q G + R
Sbjct: 120 KKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERK 179
Query: 453 CPPDDSTKSGD-SAAERKQESGISHRKEGGEE 483
K + + ERK+E R+E +E
Sbjct: 180 EKERKERKKRERNRKERKKERERKERRERKKE 211
Score = 63.2 bits (152), Expect = 5e-10
Identities = 56/239 (23%), Positives = 105/239 (43%), Gaps = 60/239 (25%)
Query: 137 QKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKK 196
+K +++ K+R + G + E +K + E+ E +E E K + +K
Sbjct: 67 EKRKREREKERKRERGKKEKKGERKK------EERERKKRRREKENKEGEEKEKRKKKEK 120
Query: 197 TTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRI 256
+ + K+R R+E+R+ R+E ERK++ E+ R+ KE +KR+RK +
Sbjct: 121 KERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKKRERKQVG-------- 172
Query: 257 PERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERASG 316
+K E+ EKE +R+K ++ KE +
Sbjct: 173 ----------------------------EKEEERKEKERKERKKRERNRKERKKE----- 199
Query: 317 QSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEEERRR 375
R E ++ K +R + E ER++E ++D++ RE+ER KR+ +ER++
Sbjct: 200 -------RERKERRERKKERKKKE------ERKKERQKDRQTNWREKERGKRERKERKK 245
>gi|239756241 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 899
Score = 95.1 bits (235), Expect = 1e-19
Identities = 85/354 (24%), Positives = 181/354 (51%), Gaps = 26/354 (7%)
Query: 141 KKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKKTTPL 200
+++ K RD + + D R+ E + EKM E + EE + + +E KKT
Sbjct: 387 EQEQKMRDQEERMWEQDERLRE-KEERMREQEKMWEQVEKMREEKKMQEQE---KKTRDQ 442
Query: 201 LSFLKNKQRMREEKR----EERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRI 256
++ ++R+RE ++ EE RE E K Q++EE W++EEK ++ R+
Sbjct: 443 EEKMQEEERIREREKKMREEEETMREQEEKMQKQEENM-WEQEEKEWQQ--------QRL 493
Query: 257 PE-RDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERAS 315
PE ++KL ++ K++ + +K ++ G EK++ ++EK + ++E+ E+
Sbjct: 494 PEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMR--EQEDQMWEQEE 551
Query: 316 GQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYE--RDQERILRERERLKRQEEER 373
K D E + EK + +++ D E+ RE E R++E+ +RE E + R++EE+
Sbjct: 552 KMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEK 611
Query: 374 RRQKER--YEKEKTFKRKEEEMKKEKDTLRDKGKKA-ESTESIGSSEK-TEKKEEVVKRD 429
+++E E+E+ +EE+M+++++ + ++ +K E E + ++ E+KE++ + +
Sbjct: 612 MQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHE 671
Query: 430 RIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQESGISHRKEGGEE 483
+++ +++ Q + + + + K+ D R++ES K+ EE
Sbjct: 672 KMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREE 725
Score = 85.5 bits (210), Expect = 1e-16
Identities = 66/283 (23%), Positives = 144/283 (50%), Gaps = 40/283 (14%)
Query: 157 DPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKRE 216
+ E R+ + EKM E L E+ E K RE K + ++ +RE+++E
Sbjct: 278 EEELREQEKKIRKQEEKMWRQEERLREQ-EGKMREQEEKMWRQEKRLREQEKELREQEKE 336
Query: 217 ERRRREI--ERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFL 274
R ++E+ + ++ +E+E + W++EEK + ++ + ++ +R+ E++K E + K+
Sbjct: 337 LREQKELREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRD-- 394
Query: 275 LQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKP 334
++ + ++ E+ EKE RE+ K ++ ++++EK
Sbjct: 395 ----QEERMWEQDERLREKEERMREQEKMWEQVE-------------------KMREEKK 431
Query: 335 KRPEDESGRDYREREREYERDQERILRERERLKRQEEERRRQKERYEKEKTFKRKEEEMK 394
+ +++ RD E+ +E ER +RERE+ R+EEE R E+E+ +++EE M
Sbjct: 432 MQEQEKKTRDQEEKMQEEER-----IREREKKMREEEETMR-----EQEEKMQKQEENMW 481
Query: 395 KEKDTLRDKGKKAESTESIGSSEKTEKKEEVV--KRDRIRNKD 435
++++ + + E E + EK +++EE + + ++IR+++
Sbjct: 482 EQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQE 524
Score = 84.3 bits (207), Expect = 2e-16
Identities = 75/312 (24%), Positives = 160/312 (51%), Gaps = 29/312 (9%)
Query: 183 EEIEAKNRELIAKKTTPLLSFLKNKQRM--REEKREERRRR----EIERKRQREE---ER 233
EE++ KN EL K PL K++ ++ +E KR+ R + +++ +EE +
Sbjct: 221 EELKKKNAELQEK--LPLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQE 278
Query: 234 RKWKEEEKRKRKDIEKL-KKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKG-- 290
+ +E+EK+ RK EK+ ++ +R+ E++ E + K+ R + Q+ L++ EK
Sbjct: 279 EELREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELR 338
Query: 291 DEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPED---ESGRDYRE 347
++KEL ++E+ + +E + ++ + ++EK R E+ E + RE
Sbjct: 339 EQKELREQEEQMQEQEEKMWEQEEKMRE-----------QEEKMWRQEERLWEQEKQMRE 387
Query: 348 REREYERDQERILRERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKA 407
+E++ +ER+ + ERL R++EER R++E+ ++ R+E++M++++ RD+ +K
Sbjct: 388 QEQKMRDQEERMWEQDERL-REKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKM 446
Query: 408 ESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAE 467
+ E I EK ++EE R++ + +++ + + P+ K +
Sbjct: 447 QEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKM 506
Query: 468 RKQESGISHRKE 479
++QE I ++E
Sbjct: 507 QEQEEKIWEQEE 518
Score = 81.3 bits (199), Expect = 2e-15
Identities = 63/312 (20%), Positives = 156/312 (50%), Gaps = 16/312 (5%)
Query: 141 KKKTKKRDTKV-----------GTIDDDPEYRKFLESYATDNEK-MTSTPETLLEEIEAK 188
+KK +K++ K+ G + + E E + EK + + L E+ E +
Sbjct: 285 EKKIRKQEEKMWRQEERLREQEGKMREQEEKMWRQEKRLREQEKELREQEKELREQKELR 344
Query: 189 NRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIE 248
+E ++ + + K R +EEK + R E+++Q E+ +K +++E+R + E
Sbjct: 345 EQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERMWEQDE 404
Query: 249 KLK-KIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKE 307
+L+ K +R+ E++K+ ++ + +Q +K ++ + +E+ + +REK + ++E
Sbjct: 405 RLREKEERMREQEKMWEQVEKMREEKKMQEQEKKTRDQEEKMQEEERIREREKKMREEEE 464
Query: 308 NLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYER---DQERILRERE 364
+ ++ Q E + ++ + PE + +E+ +E E +QE +R++E
Sbjct: 465 TMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQE 524
Query: 365 RLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEE 424
+ QE++ RQ++ E+E +EE+M+ ++ + D+ ++ E + +++E+
Sbjct: 525 EMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMEKKTQEQEKKTWDQEEK 584
Query: 425 VVKRDRIRNKDR 436
+ + +R+R +++
Sbjct: 585 MREEERMREREK 596
Score = 77.4 bits (189), Expect = 3e-14
Identities = 62/288 (21%), Positives = 152/288 (52%), Gaps = 22/288 (7%)
Query: 170 DNEKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEK--REERRRREIERKR 227
+ EKM E + E+ E K R+ + + K R +E++ +E + R+ E+K
Sbjct: 502 EQEKMQEQEEKIWEQ-EEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKM 560
Query: 228 QREEER--RKWKEEEKRKRKDIEKLKKIDRIPERDK-LKDEPKIKVHRFLLQAVNQKNLL 284
+EER +K +E+EK+ EK+++ +R+ ER+K +++E ++ + ++ +
Sbjct: 561 WDQEERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQ 620
Query: 285 KKPEK---GDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDS----ELKDEKPKRP 337
++ EK +EK ++ EK + +++ E + LP++ + E E+ K
Sbjct: 621 EQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQ 680
Query: 338 EDESGRDYREREREYERDQERILRERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEK 397
E E +E+ + ++QE+ ++E+++ +E R R+K+ E+E+ + +EE+M++++
Sbjct: 681 EQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQE 740
Query: 398 DTLRDKGKKA-ESTESIGSSEK--------TEKKEEVVKRDRIRNKDR 436
+ ++++ ++ E E + E+ E+KE++ + ++++ +++
Sbjct: 741 EKMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEK 788
Score = 77.0 bits (188), Expect = 3e-14
Identities = 69/294 (23%), Positives = 149/294 (50%), Gaps = 29/294 (9%)
Query: 141 KKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMT-STPETLLEEIEAKNRELIAKKTTP 199
+++ K RD + D + +E + EK T E + EE + RE ++
Sbjct: 548 EQEEKMRDQEQKMWDQEER----MEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEE 603
Query: 200 LLSFLKNKQRMREEKREERRRREIERK-RQREEERRKWKEEEKRKRKDIEKLKKIDRIPE 258
++ + K + +EEK +E+ + E++ + +E+E + W++EEK ++ EK+ + R+PE
Sbjct: 604 MMREQEEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE-EKMWEQQRLPE 662
Query: 259 -RDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERASGQ 317
++KL + K++ Q+ + ++ EK E+E K EK + ++ D+ +
Sbjct: 663 QKEKLWEHEKMQ---------EQEKMQEQEEKIWEQE--KMEKKTQEQEKKTWDQEKMRE 711
Query: 318 SCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEE---ERR 374
++ +R ++E+ R ++E +E+E + + +E + + E++ QEE E++
Sbjct: 712 EESMREREKKMREEEEMMREQEEK---MQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQ 768
Query: 375 RQKERYEK--EKTFKRKEEEMKKEKDTLRDKGKKAESTES--IGSSEKTEKKEE 424
R E+ EK E +++E++ ++++ +RD+ +K E G EK +EE
Sbjct: 769 RLPEQKEKLWEHEKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEE 822
Score = 68.9 bits (167), Expect = 9e-12
Identities = 68/316 (21%), Positives = 158/316 (50%), Gaps = 45/316 (14%)
Query: 141 KKKTKKRDTKVGTIDDDPEYRKFL----ESYATDNEKMTSTPETLLEEIEAKNRELIAKK 196
+KKT+ ++ K+ + E K + E+ EKM E + E+ E + ++ +
Sbjct: 436 EKKTRDQEEKMQEEERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPE 495
Query: 197 TTPLLSFLKNKQRMREEK---REERRRREIE----------RKRQREEERRKWKEEEKRK 243
L + + K + +EEK +EE+ R + E +++ RE+E + W++EEK +
Sbjct: 496 QKEKL-WEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMR 554
Query: 244 RKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKK 303
++ + + +R+ ++ + +++ + +Q+ +++ E+ E+E RE+ +
Sbjct: 555 DQEQKMWDQEERMEKKTQEQEK----------KTWDQEEKMREEERMREREKKMREEEEM 604
Query: 304 LDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYER---DQERIL 360
+ ++ +E+ Q + ++ + + E+ + ++E + E+ E E +Q+R+
Sbjct: 605 MREQ---EEKMQEQEEKMQEQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLP 661
Query: 361 RERERL----KRQEEERRRQKER--YEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIG 414
++E+L K QE+E+ +++E +E+EK K+ +E+ KK D +K ES+
Sbjct: 662 EQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQ-----EKMREEESMR 716
Query: 415 SSEKTEKKEEVVKRDR 430
EK ++EE + R++
Sbjct: 717 EREKKMREEEEMMREQ 732
Score = 68.9 bits (167), Expect = 9e-12
Identities = 51/232 (21%), Positives = 127/232 (54%), Gaps = 11/232 (4%)
Query: 207 KQRMREEKREERRRR-EIERKRQREEERR----KWKEEEKRKRKDIEKL-KKIDRIPERD 260
++RM ++ +E+ ++ + E K + EE R K +EEE+ R+ EK+ ++ +++ E++
Sbjct: 564 EERMEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMQEQE 623
Query: 261 KLKDEPKIKVHRFLLQAVNQ-KNLLKKPEKGDEKELDKREKAKKLDKENLSDERASGQSC 319
+ E + K+ + Q + + ++ EK E++ +K K + E + ++ +
Sbjct: 624 EKMWEQEEKMQEQEEKMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKMQEQ- 682
Query: 320 TLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEEERRRQKER 379
K + E ++K + E ++ + RE E R++E+ +RE E + R++EE+ +++E
Sbjct: 683 -EEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEEKMQEQEE 741
Query: 380 --YEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRD 429
E+E+ +EE+M ++++ + ++ + E E + EK +++E++ +++
Sbjct: 742 KMQEQEEEMWEQEEKMWEQEEKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQE 793
Score = 64.3 bits (155), Expect = 2e-10
Identities = 52/223 (23%), Positives = 116/223 (52%), Gaps = 20/223 (8%)
Query: 170 DNEKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKR----EERRRREIER 225
+ EKM E + E+ + + + +K T ++ ++ MRE ++ EE RE E
Sbjct: 675 EQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEMMREQEE 734
Query: 226 KRQREEERRK------WKEEEKRKRKDIEKLKKIDRIPE-RDKLKDEPKIKVHRFLLQAV 278
K Q +EE+ + W++EEK ++ EK+ + R+PE ++KL + K++ + +
Sbjct: 735 KMQEQEEKMQEQEEEMWEQEEKMWEQE-EKMWEQQRLPEQKEKLWEHEKMQEQEKIWEQE 793
Query: 279 NQKNLLKKPEKGDEKELDKREKAKKLDKENL--SDERASGQSCTLPKRSDSELKDEKPKR 336
+ ++ +G E+++ +E+ + +E + +E+ GQ + + + ++ ++ K
Sbjct: 794 EKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEE-KMWGQEEKM 852
Query: 337 PEDESGRDYREREREYERDQERILRERERLKRQEEERRRQKER 379
E G++ + RE+E E++ + E+++ QEE+ R Q+E+
Sbjct: 853 EEKMQGQEEKMREQE-----EKMRGQEEKMREQEEKMRGQEEK 890
Score = 62.8 bits (151), Expect = 7e-10
Identities = 52/229 (22%), Positives = 114/229 (49%), Gaps = 14/229 (6%)
Query: 170 DNEKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEK--REERRRREIERKR 227
++EKM + +E + +E + KKT ++++MREE+ RE ++ E +
Sbjct: 669 EHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESMREREKKMREEEEM 728
Query: 228 QREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKP 287
RE+E + ++EEK + ++ E ++ +++ E+++ E + + QK L +
Sbjct: 729 MREQEEKMQEQEEKMQEQEEEMWEQEEKMWEQEEKMWEQQ--------RLPEQKEKLWEH 780
Query: 288 EKGDEKELDKREKAKKLDKENL---SDERASGQSCTLPKRSDSELKDEKPKRPEDESGRD 344
EK E+E ++ K D+E +E+ GQ + + + E+ ++E
Sbjct: 781 EKMQEQEKIWEQEEKMRDQEEKMRGQEEKMRGQEEKMRGQEEKMWGQEEKMWGQEEKMWG 840
Query: 345 YRERE-REYERDQERILRERERLKRQEEERRRQKERYEKEKTFKRKEEE 392
E+ + E+ +E++ + E+++ QEE+ R Q+E+ +++ R +EE
Sbjct: 841 QEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEE 889
Score = 53.5 bits (127), Expect = 4e-07
Identities = 48/253 (18%), Positives = 127/253 (50%), Gaps = 31/253 (12%)
Query: 170 DNEKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMRE-EKREERRRREIERKRQ 228
+ +++ E L E + + +E + ++ + K +++ +E EK+ + + E +
Sbjct: 656 EQQRLPEQKEKLWEHEKMQEQEKMQEQEEKIWEQEKMEKKTQEQEKKTWDQEKMREEESM 715
Query: 229 REEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPE 288
RE E++ +EEE+ R+ EK+++ + +K++++ + + ++ + ++ E
Sbjct: 716 REREKK-MREEEEMMREQEEKMQE-----QEEKMQEQEEEMWEQ-------EEKMWEQEE 762
Query: 289 KGDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPK-RPEDESGRDYRE 347
K E++ +K K + E + ++ + + +++D++ K R ++E R E
Sbjct: 763 KMWEQQRLPEQKEKLWEHEKMQEQEKIWE-------QEEKMRDQEEKMRGQEEKMRGQEE 815
Query: 348 REREYER----DQERILRERERLKRQEEERRRQKERYE-----KEKTFKRKEEEMKKEKD 398
+ R E +E++ + E++ QEE+ Q+E+ E +E+ + +EE+M+ +++
Sbjct: 816 KMRGQEEKMWGQEEKMWGQEEKMWGQEEKMWGQEEKMEEKMQGQEEKMREQEEKMRGQEE 875
Query: 399 TLRDKGKKAESTE 411
+R++ +K E
Sbjct: 876 KMREQEEKMRGQE 888
Score = 31.6 bits (70), Expect = 1.7
Identities = 16/44 (36%), Positives = 29/44 (65%), Gaps = 4/44 (9%)
Query: 211 REEKREERRRREIERKRQREEERR----KWKEEEKRKRKDIEKL 250
+EEK EE+ + + E+ R++EE+ R K +E+E++ R EK+
Sbjct: 848 QEEKMEEKMQGQEEKMREQEEKMRGQEEKMREQEEKMRGQEEKI 891
>gi|239745079 PREDICTED: Putative golgin subfamily A member 6-like
protein 6 [Homo sapiens]
Length = 724
Score = 94.7 bits (234), Expect = 2e-19
Identities = 77/312 (24%), Positives = 168/312 (53%), Gaps = 26/312 (8%)
Query: 137 QKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKK 196
+K +++ K R + + + + R+ E EKM E + E+ E K REL K
Sbjct: 389 EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK-EEKIRELEEKM 447
Query: 197 TTPLLSFLKNKQRMREEK-REERRRREIERKRQREEERRKWKEEEKRKRKDIEKL-KKID 254
+ ++R EEK RE+ +R+E E K R+EE K +E+E++ R+ EK+ ++ +
Sbjct: 448 HEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE--KIREQEEKIREQEEKMWRQEE 505
Query: 255 RIPERDKLKDEPKIKVHRFLLQAVN----QKNLLKKPEKGDEKELDKREKAKKLDKENLS 310
+I E++K+++E K + + + Q+ + ++ EK E+E R++ +K+ ++
Sbjct: 506 KIHEQEKIREEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQ--- 562
Query: 311 DERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYER-----------DQERI 359
+E+ Q + ++ + + E+ R ++E R+ E+ RE E +E++
Sbjct: 563 EEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKM 622
Query: 360 LRERERLKRQEEERRRQKERY-EKEKTFKRKEEEMKKEKDTLRDKGKK--AESTESIGSS 416
+ E+++ QEE+ RRQ+E+ E+EK + +EE+++++++ ++++ +K + +
Sbjct: 623 CEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQE 682
Query: 417 EKTEKKEEVVKR 428
EK +++EE ++R
Sbjct: 683 EKMQEQEEKMRR 694
Score = 89.4 bits (220), Expect = 7e-18
Identities = 67/317 (21%), Positives = 159/317 (50%), Gaps = 26/317 (8%)
Query: 164 LESYATDNE---KMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRR 220
L++ +NE ++ E + E K +E K + ++++RE++ + RR+
Sbjct: 342 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ 401
Query: 221 REI---ERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPE-RDKLKDEPKIKVHRFLLQ 276
E+ + ++ R +E W++EEK +R++ +K ++I E +K+ ++ KI+ Q
Sbjct: 402 EEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQ 461
Query: 277 AVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKR 336
++ +++ EK E+E + +K+ ++ +E+ Q + ++ + + EK +
Sbjct: 462 ---EEEKIREQEKRQEQEAKMWRQEEKIREQ---EEKIREQEEKMWRQEEKIHEQEKIRE 515
Query: 337 PEDESGRDYREREREYERDQERILRERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKE 396
E ++ R+ E R+QE I R++E++ QEE+ R+Q+E+ R+EE+M +
Sbjct: 516 EEKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEK------MWRQEEKMHDQ 569
Query: 397 KDTLRDKGKKAESTESIGSSEKTEKKEEVVK--RDRIRNKDRPAMQLYQPGARSRNRLCP 454
++ +R++ +K E EK ++EE ++ ++IR ++ + + ++C
Sbjct: 570 EEKIREQEEKVWRQE-----EKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCE 624
Query: 455 PDDSTKSGDSAAERKQE 471
++ + + R++E
Sbjct: 625 QEEKMQEQEEKMRRQEE 641
Score = 81.3 bits (199), Expect = 2e-15
Identities = 67/352 (19%), Positives = 174/352 (49%), Gaps = 32/352 (9%)
Query: 137 QKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKK 196
+K +++ K ++ + + + + R+ E EKM E + E+ E R+
Sbjct: 361 EKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQ----- 415
Query: 197 TTPLLSFLKNKQRMREEK--REERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKID 254
++ + K R +EE +E + RE+E K +E+ R+ +EEKR+ + EK+++ +
Sbjct: 416 -EEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIRE--QEEKRQEE--EKIREQE 470
Query: 255 RIPERD--KLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDE 312
+ E++ + E KI+ ++ +K ++ + +++++ + EK ++ ++ +E
Sbjct: 471 KRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEE 530
Query: 313 RASGQSCTLPKRSDSELKDEKPKRPEDESGRD---YREREREYERDQERILRERERLKRQ 369
+ Q ++ ++EK ++ E++ R ++E + +E++ R+ E+++ Q
Sbjct: 531 KIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQ 590
Query: 370 EEERRRQKERY-EKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVK- 427
EE+ R Q+E+ E+E+ + +EE+M ++++ + ++ +K + E EK ++EE ++
Sbjct: 591 EEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQE-----EKMRRQEEKIRE 645
Query: 428 --------RDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQE 471
++IR ++ + + ++C ++ + + R++E
Sbjct: 646 QEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE 697
Score = 74.3 bits (181), Expect = 2e-13
Identities = 57/271 (21%), Positives = 140/271 (51%), Gaps = 20/271 (7%)
Query: 137 QKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKK 196
++ +++ K+++ + + + R+ E EKM E + E+ + + E K
Sbjct: 463 EEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREEE----K 518
Query: 197 TTPLLSFLKNKQRMREEKREERRRREIERKRQ--REEERRKWKEEEKRKRKDIEKLKKID 254
+ ++++RE++ R++ +I + + R++E + W++EEK ++ EK+++
Sbjct: 519 RQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQE-EKIRE-- 575
Query: 255 RIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERA 314
E + E KI+ ++ +K + ++ E E+E E+ +K+ ++ +E+
Sbjct: 576 --QEEKVWRQEEKIREQEEKIREQEEK-IREQEEMTQEQEEKMGEQEEKMCEQ---EEKM 629
Query: 315 SGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYER----DQERILRERERLKRQE 370
Q + ++ + + EK R ++E R+ E +E E +E++ + E+++ QE
Sbjct: 630 QEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE 689
Query: 371 EERRRQKER-YEKEKTFKRKEEEMKKEKDTL 400
E+ RRQ+E+ +E+E +++EE+M++ ++ L
Sbjct: 690 EKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 720
Score = 68.6 bits (166), Expect = 1e-11
Identities = 62/259 (23%), Positives = 128/259 (49%), Gaps = 16/259 (6%)
Query: 165 ESYATDNEKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIE 224
E + EK+ + +E + +E ++ + + K +EEK E+ + E
Sbjct: 457 EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEKMWRQEEKIHEQEKIREE 516
Query: 225 RKRQ------REEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAV 278
KRQ R+EE+ + +EE R+++ I + ++ R E + E K+ ++
Sbjct: 517 EKRQEQEEMWRQEEKIREQEEIWRQKEKIHEQEEKIRKQEEKMWRQEEKMHDQEEKIREQ 576
Query: 279 NQKNLLKKPEKGDEKELDKREKAKKL-DKENLSDERASGQSCTLPKRSDSELK----DEK 333
+K + ++ EK E+E RE+ +K+ ++E ++ E+ K + E K +EK
Sbjct: 577 EEK-VWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEEK 635
Query: 334 PKRPED---ESGRDYREREREYERDQERILRERERLKRQEEERRRQKER-YEKEKTFKRK 389
+R E+ E + RE+E + +E + + E++ QEE+ Q+E+ E+E+ +R+
Sbjct: 636 MRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ 695
Query: 390 EEEMKKEKDTLRDKGKKAE 408
EE+M +++ LR + +K +
Sbjct: 696 EEKMWEQEVRLRQQEEKMQ 714
Score = 63.5 bits (153), Expect = 4e-10
Identities = 48/214 (22%), Positives = 111/214 (51%), Gaps = 9/214 (4%)
Query: 170 DNEKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEK--REERRRREIERKR 227
+ EK E +E + + +E I ++ + + K R +EEK R+E + + E K
Sbjct: 515 EEEKRQEQEEMWRQEEKIREQEEIWRQKEKIHE-QEEKIRKQEEKMWRQEEKMHDQEEKI 573
Query: 228 QREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKP 287
RE+E + W++EEK + ++ + ++ ++I E++++ E + K+ + Q+ +K
Sbjct: 574 -REQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQE---EKM 629
Query: 288 EKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYRE 347
++ +EK + EK ++ +K+ E + + + + ++ +++ K E E +E
Sbjct: 630 QEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE--KMQE 687
Query: 348 REREYERDQERILRERERLKRQEEERRRQKERYE 381
+E + R +E++ + RL++QEE+ + +E E
Sbjct: 688 QEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 721
Score = 54.3 bits (129), Expect = 2e-07
Identities = 84/354 (23%), Positives = 157/354 (44%), Gaps = 60/354 (16%)
Query: 135 PFQKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTP--ETLLEEIEAKN--- 189
P A TKK+ GT +PE ++ ++E+ S E L E+EA+
Sbjct: 137 PSVGTAASDTKKKKINNGT---NPETTTSGGCHSPEDEQKASHQHQEALRRELEAQVHTI 193
Query: 190 RELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWK---EEEKRKRKD 246
R L +KT ++ ++ +++ + E R I R WK E E+
Sbjct: 194 RILTCQKTELQMALYYSQHAVKQLEGEARDL--ISRLHD------SWKFAGELEQALSAV 245
Query: 247 IEKLKKIDR-IPERDKLKDEPKIKVHRFLL--QAVNQKNL-------LKKPEKGD----E 292
+ KK DR I E K +D ++++R + + + +KN L + EK +
Sbjct: 246 ATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNV 305
Query: 293 KELDKR-EKAKKL--------DKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGR 343
KEL ++ E+AK L + ++L E S + + ++EL + ++ E++ R
Sbjct: 306 KELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWR 365
Query: 344 DYREREREYERDQERILRERERLKR---QEEERRRQKE---------------RYEKEKT 385
+ + E+ QE+ + RE+ ++ QEE+ RRQ+E +EKE+
Sbjct: 366 QEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 425
Query: 386 FKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAM 439
+R+EE M ++++ +R+ +K E I E+ ++EE ++ R + M
Sbjct: 426 MRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM 479
Score = 36.6 bits (83), Expect = 0.052
Identities = 36/174 (20%), Positives = 85/174 (48%), Gaps = 9/174 (5%)
Query: 137 QKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEA-KNRELIAK 195
+K K++ K + D + + R+ E EK+ E + E+ E + +E + +
Sbjct: 550 EKIRKQEEKMWRQEEKMHDQEEKIREQEEKVWRQEEKIREQEEKIREQEEKIREQEEMTQ 609
Query: 196 KTTPLLSFLKNKQRMREEK---REERRRREIERKRQ-----REEERRKWKEEEKRKRKDI 247
+ + + K +EEK +EE+ RR+ E+ R+ RE+E + ++EE + ++
Sbjct: 610 EQEEKMGEQEEKMCEQEEKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEE 669
Query: 248 EKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKA 301
+ ++ +++ E+++ E + K+ R + Q+ L++ E+ ++ + E A
Sbjct: 670 KMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAA 723
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 94.4 bits (233), Expect = 2e-19
Identities = 87/341 (25%), Positives = 170/341 (49%), Gaps = 54/341 (15%)
Query: 135 PFQKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTP----------ETLLEE 184
P Q A +K++ K+ V +D++ E K S+P T L
Sbjct: 443 PPQSARRKRSYKQ--AVSELDEEQHLED--EELQPPRSKTPSSPCPASKVVRPLRTFLHT 498
Query: 185 IEAKNRELIAKKTTP---LLSFLKNKQRMREEKREERRRR--EIERKRQREEERRKWKEE 239
++ +N+ L+ + P + SF+K +R + +E+ R+R + RK + E+ RR+ EE
Sbjct: 499 VQ-RNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRRQKVEE 557
Query: 240 EKRKRKDIEKLKKIDRIP------ER-DKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDE 292
+KR+R + KLK+ +R+ ER +++K+E K ++ + Q +++K K E+ E
Sbjct: 558 DKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQ-IDEKTEKAKEERLAE 616
Query: 293 KELDKREKAKKLDK-----------------ENLSDERASGQSCTLPKRSDSEL--KDEK 333
++ K+ AKK+++ + +ER + K + E K +
Sbjct: 617 EKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAE 676
Query: 334 PKRPEDESGRDYREREREYE--RDQERILRERERLKRQ--EEERRRQKERYEKEKTFKRK 389
KR ++ ++ RE+ER + R+QER +ER +RQ E+ERRR++ER + E+ + +
Sbjct: 677 AKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERELQER 736
Query: 390 EEEMKKEKDTLR---DKGKKAESTESIGSSEKTEKKEEVVK 427
E+ ++ +K+ L+ ++ KK E + + + E++E+ K
Sbjct: 737 EKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAK 777
>gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]
Length = 290
Score = 94.0 bits (232), Expect = 3e-19
Identities = 72/235 (30%), Positives = 131/235 (55%), Gaps = 32/235 (13%)
Query: 206 NKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKDE 265
++QR R+ RE + +E +R R+R+ ERR+ KE+E + +D EK +I+R ER+K
Sbjct: 76 DRQRERDRVRE-KTEKERDRDRKRDRERRR-KEKETNRNRDREKQTEIERDREREK---- 129
Query: 266 PKIKVHRFLLQAVNQKNLLKKPEKGDEKELDK-REKAKKLDKENLSDERASGQSCTLPKR 324
QK ++ ++G E+E D+ REK ++E +++ GQ T +R
Sbjct: 130 --------------QKGRERERDRGRERERDRDREK----ERERQTEKDRDGQRETETER 171
Query: 325 SDSELKDEKPKRPEDESGRDYREREREYERDQERIL-RERERLKRQEEERRRQKERYEKE 383
E E+ K+ E E+ RD R+R+R+ E+++ER RER+R ++ + ER+R+ +R +
Sbjct: 172 ---ERDREREKQKERETERD-RDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGER 227
Query: 384 KTFKRKEEEMKKE--KDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDR 436
+T +R+E + ++ K+ R++ +K E + K E+KE+ + R +K R
Sbjct: 228 ETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKERKEKKKEEKRREDKKR 282
Score = 85.9 bits (211), Expect = 8e-17
Identities = 67/227 (29%), Positives = 119/227 (52%), Gaps = 18/227 (7%)
Query: 188 KNRELIAKKTTPLLSFLKNKQRMREEKRE-ERRRREIERKRQREEERRKWKEEEKRKRKD 246
+ R+ + +KT K+R R+ KR+ ERRR+E E R R+ E++ E ++ + K
Sbjct: 79 RERDRVREKT--------EKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREKQ 130
Query: 247 IEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDK 306
+ ++ DR ER++ +D K + + +K+ + E E+E D RE+ K+ ++
Sbjct: 131 KGRERERDRGRERERDRDREKER------ERQTEKDRDGQRETETERERD-REREKQKER 183
Query: 307 ENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRERERL 366
E D + +R +D + K + RE ERE +R +ER R+R+R
Sbjct: 184 ETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGERETDRRRER-QRDRDRG 242
Query: 367 KRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESI 413
K ++ ER R++ER +KE+ +RK+E +K+K+ R + KK + E I
Sbjct: 243 KERDRERDRKEER-KKERKKERKKERKEKKKEEKRREDKKRKWGEGI 288
Score = 67.4 bits (163), Expect = 3e-11
Identities = 60/207 (28%), Positives = 101/207 (48%), Gaps = 19/207 (9%)
Query: 286 KPEKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDY 345
K GD+++ ++ +K +KE D + + +R + E + + + E RD
Sbjct: 70 KDADGDDRQRERDRVREKTEKERDRDRKRDRER----RRKEKETNRNRDREKQTEIERD- 124
Query: 346 REREREYERDQERIL-RERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKG 404
RERE++ R++ER RERER + +E+ER RQ EK++ +R E E ++E+D R+K
Sbjct: 125 REREKQKGRERERDRGRERERDRDREKERERQT---EKDRDGQR-ETETERERDREREKQ 180
Query: 405 KKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAM-----QLYQPGARSRNRLCPPD--- 456
K+ E+ TEK+ E + DR R++ R + + G R +R
Sbjct: 181 KERETERDRDRQRDTEKERE-RQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDR 239
Query: 457 DSTKSGDSAAERKQESGISHRKEGGEE 483
D K D +RK+E +KE +E
Sbjct: 240 DRGKERDRERDRKEERKKERKKERKKE 266
Score = 45.1 bits (105), Expect = 1e-04
Identities = 31/100 (31%), Positives = 53/100 (53%), Gaps = 8/100 (8%)
Query: 340 ESGRDYREREREYERDQERILRERERLKRQEEERRRQKERYEKEKTFKR---KEEEMKKE 396
++ +D +R+ ERD+ R E+ER + +R+R +ER KEK R +E++ + E
Sbjct: 67 QAHKDADGDDRQRERDRVREKTEKER----DRDRKRDRERRRKEKETNRNRDREKQTEIE 122
Query: 397 KDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDR 436
+D R+K K E G + ++ E +R+R KDR
Sbjct: 123 RDREREKQKGRERERDRGRERERDRDRE-KERERQTEKDR 161
>gi|151301171 RNA polymerase II transcription factor TAFII140 [Homo
sapiens]
Length = 929
Score = 94.0 bits (232), Expect = 3e-19
Identities = 79/284 (27%), Positives = 139/284 (48%), Gaps = 60/284 (21%)
Query: 147 RDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKN 206
R K+GT + P ++ S + TPE L + E K T L S ++
Sbjct: 475 RKAKLGTPSNMPPNFPYISSPSVS----PPTPEPLHKVYEEK---------TKLPSSVEV 521
Query: 207 KQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDR---IPERDKLK 263
K+++++E + + +++E +R R+RE+++ K K +EK K K+ EK K+ R P ++ LK
Sbjct: 522 KKKLKKELKTKMKKKEKQRDREREKDKNKDKSKEKDKVKEKEKDKETGRETKYPWKEFLK 581
Query: 264 DE----------------PKIKVHRFLLQAVNQKNLLKKP--EKGDEKELDKREKAKKLD 305
+E PK+K+ L++ +K+ KK EKG +K+ DKREK K D
Sbjct: 582 EEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREKG-KKDKDKREKEKVKD 640
Query: 306 KENLSDERASGQSCTLPKRS-------------------------DSELKDEKPKRPEDE 340
K +A LP + +L +EK K E E
Sbjct: 641 KGREDKMKAPAPPLVLPPKELALPLFSPATASRVPAMLPSLLPVLPEKLFEEKEKVKEKE 700
Query: 341 SGRDYREREREYERDQERILRERERLKRQEEERRRQKERYEKEK 384
+D +E++++ E+++E+ +ERE+ KR+ E+R ++KE+++ EK
Sbjct: 701 KKKDKKEKKKKKEKEKEKKEKEREKEKREREKREKEKEKHKHEK 744
Score = 48.1 bits (113), Expect = 2e-05
Identities = 44/159 (27%), Positives = 79/159 (49%), Gaps = 25/159 (15%)
Query: 248 EKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKE 307
EK K + + KLK E K K +KK EK ++E REK K DK
Sbjct: 511 EKTKLPSSVEVKKKLKKELKTK--------------MKKKEKQRDRE---REKDKNKDKS 553
Query: 308 NLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRERERLK 367
D+ + K + E K + ++E Y+ + +E+E D + ++ ++ L
Sbjct: 554 KEKDKVKEKEK---DKETGRETKYPWKEFLKEEEADPYKFKIKEFE-DVDPKVKLKDGLV 609
Query: 368 RQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKK 406
R+E+E+ + K++ ++EK K K+ K+EK+ ++DKG++
Sbjct: 610 RKEKEKHKDKKK-DREKGKKDKD---KREKEKVKDKGRE 644
Score = 45.8 bits (107), Expect = 9e-05
Identities = 30/135 (22%), Positives = 66/135 (48%), Gaps = 9/135 (6%)
Query: 141 KKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAK-------NRELI 193
K K KK+D + G D D ++ ++ +++ P +L E +
Sbjct: 615 KHKDKKKDREKGKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASRV 674
Query: 194 AKKTTPLLSFLKNK--QRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLK 251
LL L K + + K +E+++ + E+K+++E+E+ K ++E ++++++ EK +
Sbjct: 675 PAMLPSLLPVLPEKLFEEKEKVKEKEKKKDKKEKKKKKEKEKEKKEKEREKEKREREKRE 734
Query: 252 KIDRIPERDKLKDEP 266
K + +K+K EP
Sbjct: 735 KEKEKHKHEKIKVEP 749
Score = 43.1 bits (100), Expect = 6e-04
Identities = 41/168 (24%), Positives = 74/168 (44%), Gaps = 26/168 (15%)
Query: 292 EKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYRERERE 351
+K+L K K K KE K+ D E + +K K E + +E+E++
Sbjct: 522 KKKLKKELKTKMKKKE---------------KQRDREREKDKNKDKSKEKDK-VKEKEKD 565
Query: 352 YERDQERILRERERLKRQEEE--RRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAES 409
E +E +E LK +E + + + KE + + K K+ ++KEK+ +DK K E
Sbjct: 566 KETGRETKYPWKEFLKEEEADPYKFKIKEFEDVDPKVKLKDGLVRKEKEKHKDKKKDREK 625
Query: 410 TESIGSSEKTEKKEEVVKRDRIRNKDRP--------AMQLYQPGARSR 449
+ + EK ++ + D+++ P A+ L+ P SR
Sbjct: 626 GKKDKDKREKEKVKDKGREDKMKAPAPPLVLPPKELALPLFSPATASR 673
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 92.4 bits (228), Expect = 8e-19
Identities = 79/296 (26%), Positives = 154/296 (52%), Gaps = 36/296 (12%)
Query: 161 RKFLESYATDNEKMTST--PETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREER 218
R FL + + MT T P ++++ +N L + P SF++ K+R R E +
Sbjct: 493 RTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPL---RMDPKCSFVE-KERQRLENLRRK 548
Query: 219 RRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPER-DKLKDEPKIKVHRFLLQA 277
E R+++ EE++R+ EE K KR+ E+L+K+ + ER +++K+E K ++ + Q
Sbjct: 549 EEAEQLRRQKVEEDKRRRLEEVKLKRE--ERLRKVLQARERVEQMKEEKKKQIEQKFAQ- 605
Query: 278 VNQKNLLKKPEKGDEKELDKREKAKKLDK-----------------ENLSDERASGQSCT 320
+++K K E+ E++ K+ AKK+++ + +ER +
Sbjct: 606 IDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQ 665
Query: 321 LPKRSDSEL--KDEKPKRPEDESGRDYREREREYE--RDQERILRERERLKRQ--EEERR 374
K + E K + KR ++ ++ RE+ER + R+QER +ER +RQ E+ERR
Sbjct: 666 KKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERR 725
Query: 375 RQKERYEKEKTFKRKEEEMKKEKDTLR---DKGKKAESTESIGSSEKTEKKEEVVK 427
R++ER + E+ + +E+ ++ +K+ L+ ++ KK E + + + E++E+ K
Sbjct: 726 REQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAK 781
Score = 60.5 bits (145), Expect = 3e-09
Identities = 56/216 (25%), Positives = 107/216 (49%), Gaps = 29/216 (13%)
Query: 137 QKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKK 196
++ ++K K+ + K ID+ E K E + + +EE+EA+ ++ +
Sbjct: 589 EQMKEEKKKQIEQKFAQIDEKTEKAK--EERLAEEKAKKKAAAKKMEEVEARRKQEEEAR 646
Query: 197 TTPLLSFLKNKQRMRE------EKREERRRREIERKR---QREEERRKWKEEEKRKRKDI 247
L + ++R +E E+ +ER R+ E KR QRE+ERR+ +E +++R++
Sbjct: 647 RLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERRE-QERREQERREQ 705
Query: 248 EKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKE 307
E+ ++ R ER + E + + R LQA E+EL +REKA +L KE
Sbjct: 706 ERREQERREQERQLAEQERRREQER--LQA--------------ERELQEREKALRLQKE 749
Query: 308 NLSDERASGQSCTLPKR-SDSELKDEKPKRPEDESG 342
L E + +R ++ +L++E+ K+ ++ +G
Sbjct: 750 QLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAG 785
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 92.0 bits (227), Expect = 1e-18
Identities = 69/244 (28%), Positives = 122/244 (50%), Gaps = 46/244 (18%)
Query: 184 EIEAKNRELIAKKTTPLLSFLKNKQRMREEKREER---RRREIERKRQREEERRKWKEEE 240
E++ + I+K T S K ++R RE+++ ER R+RE +K +++ ++R+ +E
Sbjct: 16 ELQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKER 75
Query: 241 KRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREK 300
+RKRK+ EK +K R ER K K E K K + K+ +RE+
Sbjct: 76 ERKRKEREKQRKERREKERRKRKKEKK---------------------KRERKQRGRRER 114
Query: 301 AKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERIL 360
KK KE ER + K +R R ++R +E +R++ER
Sbjct: 115 KKK--KERKERER-----------------ENKQRRERKRKKRRKKKRRKERKREKERGK 155
Query: 361 RERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTE 420
RER+R KR++EER +++ER KE ++KE E K+ ++ +++ K+ + KT+
Sbjct: 156 RERKRKKRKKEEREKKRERNRKE---RKKERERKERRERKKERKKERRKKKERKKDRKTD 212
Query: 421 KKEE 424
++ +
Sbjct: 213 RQTD 216
Score = 87.4 bits (215), Expect = 3e-17
Identities = 58/197 (29%), Positives = 113/197 (57%), Gaps = 19/197 (9%)
Query: 211 REEKREERRRREIERKRQREEERRKWK-EEEKRKRKDIEKLKKIDRI-PERDKLKDEPKI 268
RE +R++ RR +RKR+RE+ER++ + ++EK+KRK E+ K+ +R ER+K + E +
Sbjct: 32 RESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERRE 91
Query: 269 KVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSE 328
K R K+ +K + K+ +RE+ KK KE ER + Q ++ +
Sbjct: 92 KERR---------KRKKEKKKRERKQRGRRERKKK--KERKERERENKQRRERKRKKRRK 140
Query: 329 LKDEKPKRPEDESGRDYRER------EREYERDQERILRERERLKRQEEERRRQKERYEK 382
K K ++ E E G+ R+R ERE +R++ R R++ER +++ ER++++++ +
Sbjct: 141 KKRRKERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERR 200
Query: 383 EKTFKRKEEEMKKEKDT 399
+K ++K+ + ++ D+
Sbjct: 201 KKKERKKDRKTDRQTDS 217
Score = 80.9 bits (198), Expect = 2e-15
Identities = 72/214 (33%), Positives = 115/214 (53%), Gaps = 40/214 (18%)
Query: 228 QREEERRKWKEE-EKRKR-KDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLK 285
QRE ER+K + E EKRKR ++ E+ +R++ K E K + K
Sbjct: 31 QRESERKKERREREKRKREREKER--------KRERGKKEKKKR---------------K 67
Query: 286 KPEKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPK--RPEDESGR 343
K E+G E+E KR++ +K KE ER KR + K E+ + R E + +
Sbjct: 68 KRERGKERE-RKRKEREKQRKERREKERR--------KRKKEKKKRERKQRGRRERKKKK 118
Query: 344 DYREREREYERDQERILRERERLKRQEEERRRQKERYEKE-KTFKRKEEEMKKEKDTLRD 402
+ +ERERE ++ +ER R++ R K++ +ER+R+KER ++E K KRK+EE +K+++ R
Sbjct: 119 ERKERERENKQRRER-KRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRERNRK 177
Query: 403 KGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDR 436
+ KK + +K KKE K++ R KDR
Sbjct: 178 ERKKERERKERRERKKERKKERRKKKE--RKKDR 209
Score = 80.1 bits (196), Expect = 4e-15
Identities = 60/221 (27%), Positives = 112/221 (50%), Gaps = 30/221 (13%)
Query: 176 STPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQR---EEE 232
S P T E K R K+ K ++ +E+K+ ++R R ER+R+R E++
Sbjct: 26 SKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQ 85
Query: 233 RRKWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDE 292
R++ +E+E+RKRK +K ++ + R++ K + + + R +N ++ K +
Sbjct: 86 RKERREKERRKRKKEKKKRERKQRGRRERKKKKERKERER--------ENKQRRERKRKK 137
Query: 293 KELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREY 352
+ KR K +K +KE R E K +K K+ E E R+ +ER+
Sbjct: 138 RRKKKRRKERKREKE----------------RGKRERKRKKRKKEEREKKRERNRKERKK 181
Query: 353 ERDQERILRERERLKRQEEERRRQKERYEKEKTFKRKEEEM 393
ER+++ RER K +++ERR++KER + KT ++ + ++
Sbjct: 182 ERERK---ERRERKKERKKERRKKKERKKDRKTDRQTDSQV 219
Score = 68.6 bits (166), Expect = 1e-11
Identities = 52/199 (26%), Positives = 99/199 (49%), Gaps = 9/199 (4%)
Query: 275 LQAVNQKNLLKK-PEKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEK 333
LQ V+ ++ K ++ E++ ++RE+ K+ + +R G+ ++ K+ +
Sbjct: 17 LQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERE 76
Query: 334 PKRPEDESGRDYREREREYERDQERILRERERLKRQEEERRRQKERYEKEKTFK-RKEEE 392
KR E E R +ER + R +++ ++RER +R ER+++KER E+E+ K R+E +
Sbjct: 77 RKRKEREKQR--KERREKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERK 134
Query: 393 MKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRL 452
KK + R K +K E G E+ KK + +R++ R ++R + + R R
Sbjct: 135 RKKRRKKKRRKERKREKER--GKRERKRKKRKKEEREKKRERNRKERKKERERKERRER- 191
Query: 453 CPPDDSTKSGDSAAERKQE 471
+ K ERK++
Sbjct: 192 --KKERKKERRKKKERKKD 208
Score = 61.6 bits (148), Expect = 2e-09
Identities = 48/162 (29%), Positives = 84/162 (51%), Gaps = 15/162 (9%)
Query: 335 KRPEDESGRDYREREREYERDQERILRERERLK-----------RQEEERRRQKERYEKE 383
+R ++ R+ R+RERE ER +ER +E+++ K R+E E++R KER EKE
Sbjct: 35 ERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQR-KERREKE 93
Query: 384 KTFKRKEEEMKKEKDT--LRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQL 441
+ KRK+E+ K+E+ R++ KK E E +++ +++ +R + R K+R +
Sbjct: 94 RR-KRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKE 152
Query: 442 YQPGARSRNRLCPPDDSTKSGDSAAERKQESGISHRKEGGEE 483
R R + + K + ERK+E R+E +E
Sbjct: 153 RGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKE 194
Score = 56.2 bits (134), Expect = 6e-08
Identities = 42/183 (22%), Positives = 86/183 (46%), Gaps = 7/183 (3%)
Query: 137 QKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKK 196
++ ++K K+ K + + +K + E+ E + E + +E +K
Sbjct: 39 ERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRK 98
Query: 197 TTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRI 256
K + R +K++ER+ RE E K++RE +R+K +++++RK + EK +
Sbjct: 99 KEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRER 158
Query: 257 PERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDK-REKAKKLDKENLSDERAS 315
+ + K+E + K R N+K K+ E+ + +E K R+K ++ KE D +
Sbjct: 159 KRKKRKKEEREKKRER------NRKERKKERERKERRERKKERKKERRKKKERKKDRKTD 212
Query: 316 GQS 318
Q+
Sbjct: 213 RQT 215
>gi|222446603 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 668
Score = 91.7 bits (226), Expect = 1e-18
Identities = 77/322 (23%), Positives = 166/322 (51%), Gaps = 41/322 (12%)
Query: 137 QKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKK 196
+K +++ K R + + + + R+ E EKM E + E+ E K REL K
Sbjct: 328 EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEK-EEKIRELEEKM 386
Query: 197 TTPLLSFLKNKQRMREEK-REERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDR 255
+ ++R EEK RE+ +R+E E K R+EE+ + ++EEK + ++ + ++ ++
Sbjct: 387 HEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIR-EQEEKIREQEKKMWRQEEK 445
Query: 256 IPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENL------ 309
I E++K+++E K + Q+ + ++ EK E+E R+K K ++E +
Sbjct: 446 IHEQEKIREEEKRQ---------EQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEK 496
Query: 310 ---SDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYE------------- 353
+E+ Q + ++ + + E+ R ++E R+ E+ RE E
Sbjct: 497 VWRQEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQ 556
Query: 354 ----RDQERILRERERLKRQEEERRRQKERY-EKEKTFKRKEEEMKKEKDTLRDKGKK-- 406
++QE++ R+ E+++ QEE+ R QKE+ E+E+ +EE+++++++ ++++ +K
Sbjct: 557 EEKMQEQEKMRRQEEKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMW 616
Query: 407 AESTESIGSSEKTEKKEEVVKR 428
+ + EK +++EE ++R
Sbjct: 617 EQEEKMCEQEEKMQEQEEKMRR 638
Score = 82.4 bits (202), Expect = 8e-16
Identities = 67/339 (19%), Positives = 168/339 (49%), Gaps = 37/339 (10%)
Query: 164 LESYATDNE---KMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRR 220
L++ +NE ++ E + E K +E K + ++++RE++ + RR+
Sbjct: 281 LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQ 340
Query: 221 REI---ERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPE-RDKLKDEPKIKVHRFLLQ 276
E+ + ++ R +E W++EEK +R + +K ++I E +K+ ++ KI+ Q
Sbjct: 341 EEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQ 400
Query: 277 AVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKR 336
++ +++ EK E+E + +K+ ++ +E+ Q + ++ + + EK +
Sbjct: 401 ---EEEKIREQEKRQEQEAKMWRQEEKIREQ---EEKIREQEKKMWRQEEKIHEQEKIRE 454
Query: 337 PEDESGRDYREREREYERDQERILR------ERERLKRQEEERRRQKER-YEKEKTFKRK 389
E ++ R+ E R+QE I R E+E++++QEE+ RQ+E+ +++E+ + +
Sbjct: 455 EEKRQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQ 514
Query: 390 EEEMKKEKDTLRDKGKK---------------AESTESIGSSEKTEKKEEVVKR--DRIR 432
EE+M ++++ +R++ +K E E +G E+ +++E ++R ++IR
Sbjct: 515 EEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQEEKIR 574
Query: 433 NKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQE 471
++ + + ++ ++ + + + ++E
Sbjct: 575 EQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEE 613
Score = 82.0 bits (201), Expect = 1e-15
Identities = 65/326 (19%), Positives = 161/326 (49%), Gaps = 19/326 (5%)
Query: 172 EKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQ--- 228
+++ + + L +E+++ + +L A+ L N+Q+ + R+E + +E E K Q
Sbjct: 261 QQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQE 320
Query: 229 ---REEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRF-LLQAVNQKNLL 284
RE+E + ++EEK +R++ +K +++ ++++ E + K+ R + ++ +
Sbjct: 321 EKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRLEEMMWEKEEKIR 380
Query: 285 KKPEKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPK--------- 335
+ EK E+E + ++ K+ ++E + ++ + R + ++++++ K
Sbjct: 381 ELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMW 440
Query: 336 RPEDESGRDYREREREYERDQERILRERERLKRQEEERRRQKERYEKEKTFKRKEEEMKK 395
R E++ + RE E ++QE + R+ E++ R++EE RQKE+ +++ +++EE++ +
Sbjct: 441 RQEEKIHEQEKIREEEKRQEQEEMWRQEEKI-REQEEIWRQKEKMHEQEKIRKQEEKVWR 499
Query: 396 EKDTLRDKGKKAESTES--IGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLC 453
+++ + D+ +K E EK ++EE ++ + +++ M Q
Sbjct: 500 QEEKMHDQEEKIREQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEK 559
Query: 454 PPDDSTKSGDSAAERKQESGISHRKE 479
+ R+QE I +KE
Sbjct: 560 MQEQEKMRRQEEKIREQEEKIREQKE 585
Score = 71.6 bits (174), Expect = 1e-12
Identities = 59/275 (21%), Positives = 149/275 (54%), Gaps = 23/275 (8%)
Query: 137 QKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKK 196
++ +++ K+++ + + + R+ E +KM E + E+ + + E K
Sbjct: 402 EEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEE----K 457
Query: 197 TTPLLSFLKNKQRMREEKREERRRREI-ERKRQREEERRKWKEEEK------RKRKDIEK 249
+ ++++RE++ R++ ++ E+++ R++E + W++EEK + R+ EK
Sbjct: 458 RQEQEEMWRQEEKIREQEEIWRQKEKMHEQEKIRKQEEKVWRQEEKMHDQEEKIREQEEK 517
Query: 250 L-KKIDRIPERDKL--KDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDK 306
+ ++ ++I E+++ + E KI+ ++Q +K + ++ EK E+E +R++ K ++
Sbjct: 518 MWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEK-MGEQEEKMQEQEKMRRQEEKIREQ 576
Query: 307 ENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRERERL 366
E E+ Q + ++ + + E+ R ++E ++ E+ E E E++ + E++
Sbjct: 577 E----EKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQE---EKMCEQEEKM 629
Query: 367 KRQEEERRRQKE-RYEKEKTFKRKEEEMKKEKDTL 400
+ QEE+ RRQ+E +E+E +++EE+M++ ++ L
Sbjct: 630 QEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHL 664
Score = 66.2 bits (160), Expect = 6e-11
Identities = 48/217 (22%), Positives = 114/217 (52%), Gaps = 10/217 (4%)
Query: 170 DNEKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEK--REERRRREIERKR 227
+ EK E +E + + +E I ++ + + K R +EEK R+E + + E K
Sbjct: 454 EEEKRQEQEEMWRQEEKIREQEEIWRQKEKMHE--QEKIRKQEEKVWRQEEKMHDQEEKI 511
Query: 228 QREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKP 287
RE+E + W++EEK + ++ + ++ ++I E++++ E + K+ + Q+ + ++
Sbjct: 512 -REQEEKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQE 570
Query: 288 EK---GDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRD 344
EK +EK +++EK ++ +++ E + + + + ++ +++ K E E
Sbjct: 571 EKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEKMCEQEE--K 628
Query: 345 YREREREYERDQERILRERERLKRQEEERRRQKERYE 381
+E+E + R +E++ + RL++QEE+ + +E E
Sbjct: 629 MQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLE 665
Score = 53.1 bits (126), Expect = 5e-07
Identities = 84/354 (23%), Positives = 156/354 (44%), Gaps = 60/354 (16%)
Query: 135 PFQKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTP--ETLLEEIEAKN--- 189
P A TKK+ GT +PE ++ ++E+ S E L E+EA+
Sbjct: 76 PSVGTAASDTKKKKINNGT---NPETTTSGGCHSPEDEQKASHQHQEALRRELEAQVHTI 132
Query: 190 RELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWK---EEEKRKRKD 246
R L +KT ++ ++ +++ + E R I R WK E E+
Sbjct: 133 RILTCQKTELQMALYYSQHAVKQLEGEARDL--ISRLHD------SWKFAGELEQALSAV 184
Query: 247 IEKLKKIDR-IPERDKLKDEPKIKVHRFLL--QAVNQKNL-------LKKPEKGD----E 292
+ KK DR I E K +D ++++R + + + +KN L + EK +
Sbjct: 185 ATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNV 244
Query: 293 KELDKR-EKAKKL--------DKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGR 343
KEL ++ E+AK L + ++L E S + + ++EL + ++ E++ R
Sbjct: 245 KELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWR 304
Query: 344 DYREREREYERDQERILRERERLKR---QEEERRRQKE---------------RYEKEKT 385
+ + E+ QE+ + RE+ ++ QEE+ RRQ+E +EKE+
Sbjct: 305 QEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEK 364
Query: 386 FKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAM 439
+R EE M ++++ +R+ +K E I E+ ++EE ++ R + M
Sbjct: 365 MRRLEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM 418
Score = 32.7 bits (73), Expect = 0.75
Identities = 31/166 (18%), Positives = 79/166 (47%), Gaps = 15/166 (9%)
Query: 137 QKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKK 196
+K +++ K R+ + + + + R+ E EKM E + E+ + + +E
Sbjct: 516 EKMWRQEEKIREQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMQEQEKMRRQE----- 570
Query: 197 TTPLLSFLKNKQRMREEK-REERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDR 255
K R +EEK RE++ + + ++ E+E + ++EE + ++ + ++ ++
Sbjct: 571 ---------EKIREQEEKIREQKEKIREQEEKIWEQEEKIREQEEMMQEQEEKMWEQEEK 621
Query: 256 IPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKA 301
+ E+++ E + K+ R + Q+ L++ E+ ++ + E A
Sbjct: 622 MCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQEHQEHLEAA 667
>gi|239747891 PREDICTED: hypothetical protein [Homo sapiens]
Length = 202
Score = 89.7 bits (221), Expect = 5e-18
Identities = 63/208 (30%), Positives = 112/208 (53%), Gaps = 11/208 (5%)
Query: 208 QRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPK 267
+R RE KRE R +E ER+R R+ ER E E R R+ ++ ++ DR +R+K ++ K
Sbjct: 2 ERQRERKRETDRGKETERERDRQRERENQTERENRHRQR-DRHRERDRQTDREKERERQK 60
Query: 268 IKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDS 327
+ + + ++ ++ E+ ++E KR+ ++ DK+ + + R
Sbjct: 61 ERDRQRQRERETERETERQRERQRQRER-KRQTDRERDKDRDRERKRETDRNRERNRKGG 119
Query: 328 ELKDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEEERRRQKERYEKEKTFK 387
+D++ +R D RERER+ +R++ER R+RER + + ER+R ER E++K K
Sbjct: 120 RERDKQTERERD------RERERQRQRERER-QRQRERKRETDRERQRWAEREERKKERK 172
Query: 388 --RKEEEMKKEKDTLRDKGKKAESTESI 413
RK+E +K+K+ R + KK + E I
Sbjct: 173 KERKKERKEKKKEEKRREDKKRKWGEGI 200
Score = 64.3 bits (155), Expect = 2e-10
Identities = 48/182 (26%), Positives = 95/182 (52%), Gaps = 11/182 (6%)
Query: 312 ERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERIL-RERERLKRQE 370
ER + + ++E + ++ + E+++ R+ R R+R+ R+++R RE+ER +++E
Sbjct: 2 ERQRERKRETDRGKETERERDRQRERENQTERENRHRQRDRHRERDRQTDREKERERQKE 61
Query: 371 EERRRQKERYEKEKTFKRKE----EEMKKEKDTLRDKGKKAE-STESIGSSEKTEK---- 421
+R+RQ+ER + +T +++E E K++ D RDK + E E+ + E+ K
Sbjct: 62 RDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRKGGRE 121
Query: 422 KEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQESGISHRKEGG 481
+++ +R+R R ++R Q + R R R D + ERK+E +KE
Sbjct: 122 RDKQTERERDRERER-QRQRERERQRQRERKRETDRERQRWAEREERKKERKKERKKERK 180
Query: 482 EE 483
E+
Sbjct: 181 EK 182
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
Length = 624
Score = 88.2 bits (217), Expect = 2e-17
Identities = 73/248 (29%), Positives = 121/248 (48%), Gaps = 29/248 (11%)
Query: 183 EEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKR 242
E ++++R K +K K+R++E+ RE+ R R E++R++E+ER K K+ +K
Sbjct: 363 ERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKERER--EKEREKEKERGKNKDRDKE 420
Query: 243 KRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAK 302
+ KD EK K+ DR ER+K ++ + K + +++ K+ EK KE+D++ K
Sbjct: 421 REKDREKDKEKDREREREKEHEKDRDK------EKEKEQDKEKEREKDRSKEIDEKRKKD 474
Query: 303 KLDK--------------ENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYRER 348
K + + R +S + R+ +K + + P S R+ +++
Sbjct: 475 KKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRS-RNKKDK 533
Query: 349 EREYERD--QERILRERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDK--- 403
+RE ERD ER RER R+ R KE+ EK T KE+E KE D+ K
Sbjct: 534 KREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNST-SLKEKEHNKEPDSSVSKEVD 592
Query: 404 GKKAESTE 411
K A TE
Sbjct: 593 DKDAPRTE 600
Score = 82.8 bits (203), Expect = 6e-16
Identities = 70/274 (25%), Positives = 123/274 (44%), Gaps = 41/274 (14%)
Query: 211 REEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKV 270
R+ + + R R R R R+++RR+ K K++ K E+ K R RDK KD
Sbjct: 326 RKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTR---- 381
Query: 271 HRFLLQAVNQKNLLKKPEKGDEKELDK-REKAKKLDKENLSDERASGQSCTLPKRSDSEL 329
+ + +K +K+ ++ E+E +K REK K+ K
Sbjct: 382 -----EKIKEKERVKEKDREKEREREKEREKEKERGKN---------------------- 414
Query: 330 KDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEEERRRQKERYEKEKTFKRK 389
KD +R +D ++RERE E++ E+ R++E+ K Q++E+ R+K+R KE KRK
Sbjct: 415 KDRDKEREKDREKDKEKDREREREKEHEKD-RDKEKEKEQDKEKEREKDR-SKEIDEKRK 472
Query: 390 EEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSR 449
+++ + + +++ S+ S E+ ++ R +K P RSR
Sbjct: 473 KDKKSRTPPRSYNASRRSRSS----SRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSR 528
Query: 450 NRLCPPDDSTKSGDSAAERKQ-ESGISHRKEGGE 482
N+ K D +ER++ E S RK +
Sbjct: 529 NK--KDKKREKERDHISERRERERSTSMRKSSND 560
Score = 82.4 bits (202), Expect = 8e-16
Identities = 76/279 (27%), Positives = 125/279 (44%), Gaps = 31/279 (11%)
Query: 205 KNKQRMREEKREERRRREIERKR-QREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLK 263
K+ + R + RE R+ R R +R++ R K KE+E+ K KD EK + +R ER+K K
Sbjct: 352 KSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKER--EREKEREKEK 409
Query: 264 DEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDK---REKAKKLDKENLSDERASGQSCT 320
+ K K + +K+ K E+ EKE +K +EK K+ DKE ER +S
Sbjct: 410 ERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEK---EREKDRSKE 466
Query: 321 LPKRSDSELKDEKPKRPEDESGR---DYREREREYERDQERILRERERLKRQEEERRRQK 377
+ ++ + K P R + S R RER R R R R + +KR+ +
Sbjct: 467 IDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPR 526
Query: 378 ERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRP 437
R +K+K + +KE+D + ++ ++ ST SS + KE++ K +
Sbjct: 527 SRNKKDK-------KREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKE--- 576
Query: 438 AMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQESGISH 476
+ N+ S + D A R +E+ I H
Sbjct: 577 ---------KEHNKEPDSSVSKEVDDKDAPRTEENKIQH 606
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
[Homo sapiens]
Length = 508
Score = 88.2 bits (217), Expect = 2e-17
Identities = 73/248 (29%), Positives = 121/248 (48%), Gaps = 29/248 (11%)
Query: 183 EEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKR 242
E ++++R K +K K+R++E+ RE+ R R E++R++E+ER K K+ +K
Sbjct: 247 ERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKERER--EKEREKEKERGKNKDRDKE 304
Query: 243 KRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAK 302
+ KD EK K+ DR ER+K ++ + K + +++ K+ EK KE+D++ K
Sbjct: 305 REKDREKDKEKDREREREKEHEKDRDK------EKEKEQDKEKEREKDRSKEIDEKRKKD 358
Query: 303 KLDK--------------ENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYRER 348
K + + R +S + R+ +K + + P S R+ +++
Sbjct: 359 KKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRS-RNKKDK 417
Query: 349 EREYERD--QERILRERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDK--- 403
+RE ERD ER RER R+ R KE+ EK T KE+E KE D+ K
Sbjct: 418 KREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNST-SLKEKEHNKEPDSSVSKEVD 476
Query: 404 GKKAESTE 411
K A TE
Sbjct: 477 DKDAPRTE 484
Score = 82.8 bits (203), Expect = 6e-16
Identities = 70/274 (25%), Positives = 123/274 (44%), Gaps = 41/274 (14%)
Query: 211 REEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKV 270
R+ + + R R R R R+++RR+ K K++ K E+ K R RDK KD
Sbjct: 210 RKRSQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTR---- 265
Query: 271 HRFLLQAVNQKNLLKKPEKGDEKELDK-REKAKKLDKENLSDERASGQSCTLPKRSDSEL 329
+ + +K +K+ ++ E+E +K REK K+ K
Sbjct: 266 -----EKIKEKERVKEKDREKEREREKEREKEKERGKN---------------------- 298
Query: 330 KDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEEERRRQKERYEKEKTFKRK 389
KD +R +D ++RERE E++ E+ R++E+ K Q++E+ R+K+R KE KRK
Sbjct: 299 KDRDKEREKDREKDKEKDREREREKEHEKD-RDKEKEKEQDKEKEREKDR-SKEIDEKRK 356
Query: 390 EEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSR 449
+++ + + +++ S+ S E+ ++ R +K P RSR
Sbjct: 357 KDKKSRTPPRSYNASRRSRSS----SRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSR 412
Query: 450 NRLCPPDDSTKSGDSAAERKQ-ESGISHRKEGGE 482
N+ K D +ER++ E S RK +
Sbjct: 413 NK--KDKKREKERDHISERRERERSTSMRKSSND 444
Score = 82.4 bits (202), Expect = 8e-16
Identities = 76/279 (27%), Positives = 125/279 (44%), Gaps = 31/279 (11%)
Query: 205 KNKQRMREEKREERRRREIERKR-QREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLK 263
K+ + R + RE R+ R R +R++ R K KE+E+ K KD EK + +R ER+K K
Sbjct: 236 KSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKER--EREKEREKEK 293
Query: 264 DEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDK---REKAKKLDKENLSDERASGQSCT 320
+ K K + +K+ K E+ EKE +K +EK K+ DKE ER +S
Sbjct: 294 ERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDKEKEKEQDKEK---EREKDRSKE 350
Query: 321 LPKRSDSELKDEKPKRPEDESGR---DYREREREYERDQERILRERERLKRQEEERRRQK 377
+ ++ + K P R + S R RER R R R R + +KR+ +
Sbjct: 351 IDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRRRSRSSSRSPRTSKTIKRKSSRSPSPR 410
Query: 378 ERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRP 437
R +K+K + +KE+D + ++ ++ ST SS + KE++ K +
Sbjct: 411 SRNKKDK-------KREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKE--- 460
Query: 438 AMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQESGISH 476
+ N+ S + D A R +E+ I H
Sbjct: 461 ---------KEHNKEPDSSVSKEVDDKDAPRTEENKIQH 490
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 88.2 bits (217), Expect = 2e-17
Identities = 70/273 (25%), Positives = 129/273 (47%), Gaps = 19/273 (6%)
Query: 202 SFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDK 261
S+ + + + R++ R ER R E +RR +E ++R I + D + ERD+
Sbjct: 601 SYPERDRYPERDNRDQARDSSFER-RHGERDRRDNRERDQRPSSPIRHQGRNDEL-ERDE 658
Query: 262 LKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDK---REKAKKLDKENLSDERASGQS 318
++E ++ V+ + + E+ E+E D+ RE+ ++ D+E + +
Sbjct: 659 RREERRV-------DRVDDRRDERARERDRERERDRERERERERERDREREKERELERER 711
Query: 319 CTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEEERRRQKE 378
+R + +D + R D RERER+ E+++ER ERER + +E ER R++E
Sbjct: 712 AREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERERERERERERE 771
Query: 379 RYEKEKTFKRKEEEMKKEKDTLRDKGK--KAESTESIGSSEK-TEKKEEVVKRDRIRNKD 435
R E+E+ +R +E ++ +DKG+ + E E I + +E + R RN+
Sbjct: 772 R-ERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEG 830
Query: 436 RPAMQLYQPGARSRNRLCPPDDSTKSGDSAAER 468
P+ + + R P D+ SGD E+
Sbjct: 831 SPSP---RQSPKRRREHSPDSDAYNSGDDKNEK 860
Score = 79.3 bits (194), Expect = 7e-15
Identities = 84/338 (24%), Positives = 141/338 (41%), Gaps = 56/338 (16%)
Query: 158 PEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREE 217
PE ++ E D + +S E NRE + ++P+ +N + R+E+REE
Sbjct: 603 PERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREE 662
Query: 218 RR---------------RREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKL 262
RR RE ER R+RE ER + ++ E+ K +++E+ + +R ER+K
Sbjct: 663 RRVDRVDDRRDERARERDRERERDRERERERERERDREREKERELERERAREREREREKE 722
Query: 263 KDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDK-REKAKKLDKENLSDERASGQSCTL 321
+D E+ +++ D+ RE+ ++ D+E ER
Sbjct: 723 RDR----------------------ERDRDRDHDRERERERERDREK---ER-------- 749
Query: 322 PKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEEERRRQKERYE 381
+R E + E+ + E E R+ RERER ERD+ER + K + + RR+K
Sbjct: 750 -EREREERERERERERERERERE-RERERARERDKERERQRDWEDKDKGRDDRREKREEI 807
Query: 382 KEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQL 441
+E R + +K K R++G + E + + D K R Q+
Sbjct: 808 REDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQV 867
Query: 442 YQPGARSRNRLCPPDDSTKSGDSAAERKQESGISHRKE 479
+P +R P T+ D K+E RKE
Sbjct: 868 VRP---QESRSLSPSHLTE--DRQGRWKEEDRKPERKE 900
Score = 72.8 bits (177), Expect = 7e-13
Identities = 71/291 (24%), Positives = 136/291 (46%), Gaps = 30/291 (10%)
Query: 141 KKKTKKRDTKVGTIDD--DPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKKTT 198
++ ++ + +V +DD D R+ D E+ E E K REL ++
Sbjct: 655 ERDERREERRVDRVDDRRDERARERDRERERDRERERERERERDRERE-KERELERERAR 713
Query: 199 PLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPE 258
+ ++R +E RE R R+ +R+R+RE ER + KE E R+R++ E+ ++ +R E
Sbjct: 714 E-----REREREKERDRERDRDRDHDRERERERERDREKERE-REREERERERERERERE 767
Query: 259 RDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDK---------ENL 309
R++ ++ + + + ++ + E D+ D+REK +++ + E
Sbjct: 768 RERERERERAR------ERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERK 821
Query: 310 SDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYRERER---EYERDQERILRERERL 366
S +R + P++S ++ P SG D E+ R + R QE L
Sbjct: 822 SKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHL 881
Query: 367 KRQEEERRRQKERY-EKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSS 416
+ R ++++R E++++ +R EE+ KEK + D K+ E TE + SS
Sbjct: 882 TEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVD--KQREQTEILESS 930
Score = 58.5 bits (140), Expect = 1e-08
Identities = 65/316 (20%), Positives = 127/316 (40%), Gaps = 42/316 (13%)
Query: 204 LKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLK 263
L++ + MR+ + R+ + R + R + R R+ + +K D PE +
Sbjct: 470 LRDSRDMRDSREMRDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSY 529
Query: 264 DEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERAS-------- 315
++ + N+ + E +++ R + +L ++ R S
Sbjct: 530 GRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSN 589
Query: 316 -GQSCTLPKRSDSELKDEKPKRPEDESGRD------YRERER------------------ 350
+ RS +D P+R + RD + ER+R
Sbjct: 590 SNYHDSWETRSSYPERDRYPERDNRDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQG 649
Query: 351 ---EYERDQERILRERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKA 407
E ERD+ R R +R+ + +ER R+++R E+E+ + +E E ++E+D R+K ++
Sbjct: 650 RNDELERDERREERRVDRVDDRRDERARERDR-ERERD-RERERERERERDREREKEREL 707
Query: 408 ESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAE 467
E E E+ +KE +RDR R+ DR + + R R + + + + E
Sbjct: 708 E-RERAREREREREKERDRERDRDRDHDR---ERERERERDREKEREREREERERERERE 763
Query: 468 RKQESGISHRKEGGEE 483
R++E +E E
Sbjct: 764 RERERERERERERARE 779
Score = 52.8 bits (125), Expect = 7e-07
Identities = 58/286 (20%), Positives = 117/286 (40%), Gaps = 72/286 (25%)
Query: 205 KNKQRMREEKREERRRREIERKRQREEER---RKWKEEEKRKRKDIEKLKKI--DRIP-- 257
+ ++R RE +RE R RE ER R+R++ER R W++++K + EK ++I DR P
Sbjct: 756 RERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRD 815
Query: 258 ---ERDKLK-----------------------------DEPKIKVHRFLLQAVNQKNL-- 283
ER K + K + HR L Q V +
Sbjct: 816 GHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRS 875
Query: 284 -----LKKPEKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPE 338
L + +G KE D++ + K+ + E S +R +E+ + R +
Sbjct: 876 LSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQ 935
Query: 339 DESGR----DYREREREYERDQERILRERERLKRQEEE---------------------- 372
D G D +R ++ ++++ +++ +K+++E+
Sbjct: 936 DIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTSEDGQVFSPK 995
Query: 373 RRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEK 418
+ ++K+ EK++ + + ++ E+ + K K+ T I + E+
Sbjct: 996 KGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEE 1041
Score = 49.3 bits (116), Expect = 8e-06
Identities = 41/195 (21%), Positives = 89/195 (45%), Gaps = 12/195 (6%)
Query: 134 APFQKAAKKKTKKRDTKV-GTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNREL 192
+P Q +++ D+ + DD E + L E + +P L E+ + + +E
Sbjct: 833 SPRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEE 892
Query: 193 IAKKTTPLLSFLKNKQRMREEKREERRRRE----IERKRQREEE-----RRKWKEEEKRK 243
K S +Q ++E+ ++RE +E R R ++ + + +E R
Sbjct: 893 DRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRMRAQDIIGHHQSEDRETSDRA 952
Query: 244 RKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKK 303
+ +K KI + P + K +D+ + + R ++ ++ + P+KG +K+ ++++ K
Sbjct: 953 HDENKKKAKIQKKPIKKKKEDD--VGIERGNIETTSEDGQVFSPKKGQKKKSIEKKRKKS 1010
Query: 304 LDKENLSDERASGQS 318
++SDE A+ QS
Sbjct: 1011 KGDSDISDEEAAQQS 1025
Score = 49.3 bits (116), Expect = 8e-06
Identities = 73/341 (21%), Positives = 140/341 (41%), Gaps = 58/341 (17%)
Query: 148 DTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNK 207
+T T ++ +RK + T EK+ TP +E+ + + + + K+++ L S N+
Sbjct: 1145 NTTNNTFANEDSHRK---CHRTRVEKV-ETPHVTIEDAQHR-KPMDQKRSSSLGSNRSNR 1199
Query: 208 QRMREEKREERRRREIERKRQREEERRKWKEEEKRKR------KDIEKLKKIDRIPERDK 261
R + R ++ RKR +D EK K ++ ER
Sbjct: 1200 SHTSGRLRSP----------SNDSAHRSGDDQSGRKRVLHSGSRDREKTKSLEITGERKS 1249
Query: 262 LKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENL--SDERASGQSC 319
D+ LK+ E D+++ + + SD + +S
Sbjct: 1250 RIDQ------------------LKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSG 1291
Query: 320 TLPKRSDSELKDE-KPKRPEDESGRDYRERE--REYERDQERILRERERLKRQEEERRRQ 376
+ R + +D + R + RD R+RE R+ ++D R R+R+RL+ +E ER R
Sbjct: 1292 SFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRN-RDRDRLRERERERERD 1350
Query: 377 KERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSE-----KTEKKEEVVKRDRI 431
K R + + + +++++D RD+ ++ ES+ E + E+ E RD +
Sbjct: 1351 KRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERDLESTSRDSL 1410
Query: 432 ------RNKDRPAMQLYQPGARSR--NRLCPPDDSTKSGDS 464
+KD ++Q ++ +S L DD +K D+
Sbjct: 1411 ALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESKLDDA 1451
Score = 43.9 bits (102), Expect = 3e-04
Identities = 77/366 (21%), Positives = 133/366 (36%), Gaps = 55/366 (15%)
Query: 134 APFQKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELI 193
+P +A KK +K + D K +S + S P + E+I +
Sbjct: 224 SPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQS-KKKGPRTPSPPPPIPEDIA------L 276
Query: 194 AKKTTPLLSFLKNKQRMREEKREERRR-REIERKRQREEERRKWKE--------EEKRKR 244
KK K K R+ E+ R+ + R R+ ER+R++ ++ R +
Sbjct: 277 GKKYKEKY---KVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPISSRHHS 333
Query: 245 KDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQK------NLLKKPEKGDEKELDKR 298
+ I R + K P R L + + + L P++ K+ R
Sbjct: 334 SSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSSPQR---KQSPPR 390
Query: 299 EKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYRER----EREYER 354
++ +K ER S + D + +R ED G+ RE+ EREYE+
Sbjct: 391 HRSPMREKGRHDHERTS------------QSHDRRHERREDTRGKRDREKDSREEREYEQ 438
Query: 355 DQERILRERERLKRQEEERRRQKERYEKEKTFKRKE-EEMKKEKDTLRDKGKKAESTESI 413
DQ R R + E R ++R + T R+E + + +D+ + ++ ES
Sbjct: 439 DQ-----SSSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESR 493
Query: 414 GSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQESG 473
+ ++ RDR Y +RS R + + S E + ES
Sbjct: 494 DPRDSRSTRDAHDYRDREGRDTHRKEDTYPEESRSYGR-----NHLREESSRTEIRNESR 548
Query: 474 ISHRKE 479
R E
Sbjct: 549 NESRSE 554
Score = 39.7 bits (91), Expect = 0.006
Identities = 71/378 (18%), Positives = 140/378 (37%), Gaps = 44/378 (11%)
Query: 143 KTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKKTTP--- 199
+T + D+ G I+ D + LE +K+ L +E K E+I KK
Sbjct: 145 ETNRDDSDNGDINYDYVHELSLEM---KRQKIQRELMKLEQENMEKREEIIIKKEVSPEV 201
Query: 200 LLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKE-----EEKRKRKDIEKLKKID 254
+ S L +R+ + +R+ + +++R+ +++R K + KK
Sbjct: 202 VRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKKKGP 261
Query: 255 RIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERA 314
R P E ++ + + + +K G ++ D + +K DK +
Sbjct: 262 RTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAG 321
Query: 315 SGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILR------------- 361
S + S + + S R R Y+R LR
Sbjct: 322 QHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASPYPSHSLSS 381
Query: 362 -ERERLKRQEEERRRQKERYEKEKT-------FKRKEEEMKK---EKDTLRDKGKKAEST 410
+R++ + R+K R++ E+T +R+E+ K EKD+ ++ + + +
Sbjct: 382 PQRKQSPPRHRSPMREKGRHDHERTSQSHDRRHERREDTRGKRDREKDSREEREYEQDQS 441
Query: 411 ESIGSSEKTEKKEEVVKRDRIRNKDRPAM---------QLYQPGARSRNRLCPPDDSTKS 461
S + E ++ +RD +DR + + + +R P DS +
Sbjct: 442 SSRDHRDDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDPRDSRST 501
Query: 462 GDSAAERKQESGISHRKE 479
D+ R +E +HRKE
Sbjct: 502 RDAHDYRDREGRDTHRKE 519
Score = 38.1 bits (87), Expect = 0.018
Identities = 56/279 (20%), Positives = 112/279 (40%), Gaps = 20/279 (7%)
Query: 195 KKTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEE----KRKRKDIEKL 250
+ T L +KNK++ + + ++R E ++E R + +E+E ++R +
Sbjct: 80 RPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEE 139
Query: 251 KKIDRIPERDKLKDEPKIK---VHRFLLQAVNQK---NLLKKPEKGDEKE---LDKREKA 301
+ ++ RD D I VH L+ QK L+K ++ EK + K+E +
Sbjct: 140 ENVEWETNRDD-SDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVS 198
Query: 302 KKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDY----REREREYERDQE 357
++ + LS + +S PKR S K+ S ++R + + ++
Sbjct: 199 PEVVRSKLSPSPSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSPLLDQQRNSKTNQSKK 258
Query: 358 RILRERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSE 417
+ R E+ K+ EK K R EE+ + KD RD ++ E + S+
Sbjct: 259 KGPRTPSPPPPIPEDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTS 318
Query: 418 KTEKKEEVV--KRDRIRNKDRPAMQLYQPGARSRNRLCP 454
+ + + ++ ++Q + P R + P
Sbjct: 319 PAGQHHSPISSRHHSSSSQSGSSIQRHSPSPRRKRTPSP 357
Score = 37.0 bits (84), Expect = 0.040
Identities = 50/243 (20%), Positives = 90/243 (37%), Gaps = 56/243 (23%)
Query: 205 KNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKD 264
+++ MRE+ R + R + +RR + E+ R ++D EK D ER+ +D
Sbjct: 390 RHRSPMREKGRHDHERTS------QSHDRRHERREDTRGKRDREK----DSREEREYEQD 439
Query: 265 EPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKR 324
+ + HR D RE D+ + D R
Sbjct: 440 QSSSRDHR-----------------------DDREPRDGRDRRDARDTR----------- 465
Query: 325 SDSELKDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEEERRRQKERYEKEK 384
EL+D + R D RE R+Y RD + R+ ++ R +E +
Sbjct: 466 DRRELRDSRDMR-------DSREM-RDYSRDTKESRDPRDSRSTRDAHDYRDREGRDTH- 516
Query: 385 TFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQP 444
RKE+ +E + + ES+ + +E + ++ DR+ +L +
Sbjct: 517 ---RKEDTYPEESRSYGRNHLREESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEK 573
Query: 445 GAR 447
G+R
Sbjct: 574 GSR 576
Score = 35.0 bits (79), Expect = 0.15
Identities = 41/168 (24%), Positives = 61/168 (36%), Gaps = 34/168 (20%)
Query: 310 SDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYR-EREREYERDQERILRERERLKR 368
S ER +G K ++ E KR +ES R E R R++E I +ER
Sbjct: 77 SPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKERTPE 136
Query: 369 QEEER--------------------------------RRQKERYEKEKTFKRKEEEMKKE 396
EEE +R+ + E+E KR+E +KKE
Sbjct: 137 SEEENVEWETNRDDSDNGDINYDYVHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKE 196
Query: 397 KDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQP 444
+ K + S S+ S K+ K++ K KDR + P
Sbjct: 197 VSPEVVRSKLSPS-PSLRKSSKSPKRKSSPKSSSASKKDRKTSAVSSP 243
Score = 30.4 bits (67), Expect = 3.7
Identities = 27/87 (31%), Positives = 37/87 (42%), Gaps = 8/87 (9%)
Query: 352 YERDQERI---LRERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAE 408
Y R ER LRER + KRQ+ + QK E+ + RKE + ++ K K
Sbjct: 74 YRRSPERPTGDLRERMKNKRQDVDTEPQKRNTEESSSPVRKESSRGRHREKEDIKITKER 133
Query: 409 STESIGSSEKTEKKEEVVKRDRIRNKD 435
+ ES + E E RD N D
Sbjct: 134 TPES-----EEENVEWETNRDDSDNGD 155
>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
sapiens]
Length = 750
Score = 85.1 bits (209), Expect = 1e-16
Identities = 80/348 (22%), Positives = 174/348 (50%), Gaps = 63/348 (18%)
Query: 141 KKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKKTTPL 200
+K+ K R + + + + R+ E EKM E + E+ E K REL K
Sbjct: 346 EKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEK-EEKIRELEEKMHEQE 404
Query: 201 LSFLKNKQRMREEK-REERRRREIERKRQREEER-----RKWKEEEKRKRKDIEKLKKID 254
+ ++R EEK RE+ +R+E E K R+EE+ K +E+EK+ + EK+ + +
Sbjct: 405 KIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQE 464
Query: 255 RIPERDKLKDEPKI-----KVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENL 309
+I E +K +++ ++ K+H Q+ + ++ EK E+E R++ +K+ ++
Sbjct: 465 KIREEEKRQEQEEMWRQEEKIHE-------QEEIWRQKEKMHEQEEKIRKQEEKVWRQ-- 515
Query: 310 SDERASGQSCTLPKRSDSELKDEKPKRPEDESGRD----------YREREREYERD---- 355
+E+ Q + ++ + + E+ R ++E R+ + E +R+ + D
Sbjct: 516 -EEKIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWR 574
Query: 356 --------QERILRERERLKRQEEERRRQKERY--------EKEKTFKRKEEEMKKEKDT 399
+E++ R+ E+++ QEE+R+ Q+E+ E+E+ + +EE+++++++
Sbjct: 575 QEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEK 634
Query: 400 LRDKGKKA-ESTESIG--------SSEKTEKKEEVVKR--DRIRNKDR 436
+R++ + E E +G EK +++EE + R ++IR +++
Sbjct: 635 IREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEK 682
Score = 84.7 bits (208), Expect = 2e-16
Identities = 61/264 (23%), Positives = 142/264 (53%), Gaps = 14/264 (5%)
Query: 179 ETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREI----ERKRQREEERR 234
E ++E E K RE +K ++ ++ M EK E+ RR+E + ++ R +E
Sbjct: 313 EEKIQEQEEKIREQ-EEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEM 371
Query: 235 KWKEEEKRKRKDIEKLKKIDRIPE-RDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEK 293
W++EEK +R++ +K ++I E +K+ ++ KI+ Q ++ +++ EK E+
Sbjct: 372 MWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQ---EEEKIREQEKRQEQ 428
Query: 294 ELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYE 353
E + +K+ ++ +E+ Q + ++ + + EK + E ++ R+ E
Sbjct: 429 EAKMWRQEEKIREQ---EEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKI 485
Query: 354 RDQERILRERERLKRQEEERRRQKER-YEKEKTFKRKEEEMKKEKDTL-RDKGKKAESTE 411
+QE I R++E++ QEE+ R+Q+E+ + +E+ + +EE+++++++ + R + K E E
Sbjct: 486 HEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIREQEE 545
Query: 412 SIGSSEKTEKKEEVVKRDRIRNKD 435
EK ++E++ + ++ + ++
Sbjct: 546 MWREEEKMHEQEKIWEEEKRQEQE 569
Score = 83.6 bits (205), Expect = 4e-16
Identities = 55/314 (17%), Positives = 159/314 (50%), Gaps = 12/314 (3%)
Query: 181 LLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEE 240
L + + E + ++ + + + Q E+ RE+ + + ++ R +E W++EE
Sbjct: 290 LWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEE 349
Query: 241 KRKRKDIEKLKKIDRIPERDKLKDEPKIKVHR-FLLQAVNQKNLLKKPEKGDEKELDKRE 299
K +R++ +K +++ ++++ E + K+ R + ++ + + EK E+E + +
Sbjct: 350 KMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQ 409
Query: 300 KAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPK---------RPEDESGRDYRERER 350
+ K+ ++E + ++ + R + ++++++ K R E++ + RE
Sbjct: 410 EEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIREE 469
Query: 351 EYERDQERILRERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKK-AES 409
E ++QE + R+ E++ QEE R++++ +E+E+ +++EE++ ++++ +R++ +K E
Sbjct: 470 EKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQ 529
Query: 410 TESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERK 469
E + E+ +++E + R+ + ++ + + +++ ++ + + R
Sbjct: 530 EEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWR- 588
Query: 470 QESGISHRKEGGEE 483
QE I ++E +E
Sbjct: 589 QEEKIREQEEKRQE 602
Score = 80.1 bits (196), Expect = 4e-15
Identities = 58/235 (24%), Positives = 134/235 (57%), Gaps = 19/235 (8%)
Query: 205 KNKQRMREEK--REERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKL 262
+ K R +EEK R+E + RE E K RE+E + W++EEK + ++ E ++ +++ E++K+
Sbjct: 502 EEKIRKQEEKVWRQEEKIREQEEKI-REQEEKMWRQEEKIREQE-EMWREEEKMHEQEKI 559
Query: 263 KDEPKIKVHRFLLQAVNQK------NLLKKPEKGDEKELDKREKAKKLDKENLSDERASG 316
+E K + + +K + ++ EK E+E ++E+ +K+ K+ +E+
Sbjct: 560 WEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQ---EEKIRE 616
Query: 317 QSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEEERRRQ 376
Q + ++ + + E+ R ++E ++ E+ E E E++ + E+++ QEE RQ
Sbjct: 617 QEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQE---EKMCEQEEKMQEQEETMWRQ 673
Query: 377 KERY-EKEKTFKRKEEEMKKEKDTLRDKGKK--AESTESIGSSEKTEKKEEVVKR 428
+E+ E+EK + +EE+++++++ ++++ +K + + EK +++EE ++R
Sbjct: 674 EEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR 728
Score = 79.3 bits (194), Expect = 7e-15
Identities = 62/260 (23%), Positives = 138/260 (53%), Gaps = 17/260 (6%)
Query: 141 KKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKKTTPL 200
++K +K++ KV ++ + R+ E EKM E + E+ E E + +
Sbjct: 502 EEKIRKQEEKVWRQEE--KIREQEEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKI 559
Query: 201 LSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERD 260
K +++ + R+E + RE E K R+EE+ + ++EEKR+ ++ + K+ ++I E++
Sbjct: 560 WEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIR-EQEEKRQEQEEKMWKQEEKIREQE 618
Query: 261 KLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERASGQSCT 320
+ E + K+ ++ + ++ E E+E E+ +K+ ++ +E+ Q T
Sbjct: 619 EKIQEQEEKIRE------QEEKIREQEEMTQEQEEKMGEQEEKMCEQ---EEKMQEQEET 669
Query: 321 LPKRSDSELKDEKPKRPEDESGRDYREREREYER----DQERILRERERLKRQEEERRRQ 376
+ ++ + + EK R ++E R+ E +E E +E++ + E+++ QEE+ RRQ
Sbjct: 670 MWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQ 729
Query: 377 KER-YEKEKTFKRKEEEMKK 395
+E+ +E+E +++EE+M++
Sbjct: 730 EEKMWEQEVRLRQQEEKMQE 749
Score = 79.0 bits (193), Expect = 9e-15
Identities = 59/262 (22%), Positives = 142/262 (54%), Gaps = 17/262 (6%)
Query: 165 ESYATDNEKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIE 224
E EK+ E + E+ E K RE K + ++ REE++ + + E
Sbjct: 503 EKIRKQEEKVWRQEEKIREQ-EEKIREQEEKMWRQEEKIREQEEMWREEEKMHEQEKIWE 561
Query: 225 RKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLL 284
++++E+E + W++EEK + ++ + ++ ++I E+++ + E + K+ + ++ +
Sbjct: 562 EEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWK------QEEKIR 615
Query: 285 KKPEKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRD 344
++ EK E+E RE+ +K+ ++ +E Q + ++ + + E+ + ++E+
Sbjct: 616 EQEEKIQEQEEKIREQEEKIREQ---EEMTQEQEEKMGEQEEKMCEQEEKMQEQEET--- 669
Query: 345 YREREREYERDQERILRERE-RLKRQEEERRRQKER-YEKEKTFKRKEEEMKKEKDTLRD 402
R+ E R+QE+ +RE+E +++ QEE + Q+E+ +E+E+ +EE+M+++++ +R
Sbjct: 670 -MWRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR 728
Query: 403 KGKKAESTESIGSSEKTEKKEE 424
+ +K E + ++ EK +E
Sbjct: 729 QEEKMWEQE-VRLRQQEEKMQE 749
Score = 78.2 bits (191), Expect = 2e-14
Identities = 62/297 (20%), Positives = 151/297 (50%), Gaps = 12/297 (4%)
Query: 186 EAKNRELIAKKTTPLLSFLKNKQRMRE-EKREERRRREIERKRQREEERRKWKEEEKRKR 244
E K RE K + ++++ E EK E +R+ + + R+EE+ +EE R++
Sbjct: 436 EEKIREQEEKIREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQK 495
Query: 245 KDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKL 304
+ + + ++ R E + E KI+ ++ +K + ++ EK E+E RE+ K
Sbjct: 496 EKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEK-MWRQEEKIREQEEMWREEEKMH 554
Query: 305 DKENLSDERASGQSCTLPKRSDSELKDEKPK-RPEDESGRDYREREREYE----RDQERI 359
++E + +E + R + ++++++ K ++E R+ E+ +E E + +E+I
Sbjct: 555 EQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQEQEEKMWKQEEKI 614
Query: 360 LRERERLKRQEEERRRQKERY-EKEKTFKRKEEEMKKEKDTLRDKGKKAESTESI--GSS 416
+ E+++ QEE+ R Q+E+ E+E+ + +EE+M ++++ + ++ +K + E
Sbjct: 615 REQEEKIQEQEEKIREQEEKIREQEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQE 674
Query: 417 EKTEKKEEVVK--RDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQE 471
EK ++E+ ++ ++IR ++ + + ++C ++ + + R++E
Sbjct: 675 EKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEE 731
Score = 74.7 bits (182), Expect = 2e-13
Identities = 52/273 (19%), Positives = 136/273 (49%), Gaps = 12/273 (4%)
Query: 205 KNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKD 264
K Q + + + + E+ + +++E + W++EEK + + + ++ ++I E+++
Sbjct: 272 KELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIR 331
Query: 265 EPKIKVHRFLLQAVNQKNLLKKPEK---GDEKELDKREKAKKLDKENLSDERASGQSCTL 321
E + K+ R ++ + +K EK +E +K EK ++ ++ E + +
Sbjct: 332 EQEEKMRR------QEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEM 385
Query: 322 PKRSDSELKDEKPKRPEDESGRDYREREREYE--RDQERILRERERLKRQEEERRRQKER 379
+ ++++ + K E E R+ E+ +E E R+QE+ + ++ RQEE+ R Q+E+
Sbjct: 386 MWEKEEKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEK 445
Query: 380 YEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVK-RDRIRNKDRPA 438
+++ ++EE E++ +R++ K+ E E EK ++EE+ + ++++ ++
Sbjct: 446 IREQEKKMWRQEEKIHEQEKIREEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKI 505
Query: 439 MQLYQPGARSRNRLCPPDDSTKSGDSAAERKQE 471
+ + R ++ ++ + + R++E
Sbjct: 506 RKQEEKVWRQEEKIREQEEKIREQEEKMWRQEE 538
Score = 66.6 bits (161), Expect = 5e-11
Identities = 63/282 (22%), Positives = 134/282 (47%), Gaps = 26/282 (9%)
Query: 159 EYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREER 218
E + L + AT +K E L +E +A + EL T +E+ +E+
Sbjct: 176 ELEQALSAVATQKKKADRYIEELTKERDALSLELYRNTIT-------------DEELKEK 222
Query: 219 RRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAV 278
+ E+ + E E+ + + K ++ +E+ K + +P++ + + LQ+V
Sbjct: 223 NAKLQEKLQLVESEKSEIQLNVKELKRKLERAKLL--LPQQQLQAEADHLGKE---LQSV 277
Query: 279 NQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPE 338
+ K + +E EL R ++ +K +E+ + ++ + + E+ R +
Sbjct: 278 SAK----LQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQ 333
Query: 339 DESGRDYREREREYERDQERILRERERLKRQEEERRRQKER-YEKEKTFKRKEEEMKKEK 397
+E R R+ E +E++ E++ R+ E + +EE+ RRQ+E +EKE+ +R+EE M +++
Sbjct: 334 EEKMR--RQEEMMWEKE-EKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKE 390
Query: 398 DTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAM 439
+ +R+ +K E I E+ ++EE ++ R + M
Sbjct: 391 EKIRELEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKM 432
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 84.7 bits (208), Expect = 2e-16
Identities = 68/297 (22%), Positives = 154/297 (51%), Gaps = 36/297 (12%)
Query: 141 KKKTKKRDTKVGT----IDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKK 196
++K ++R+ K+ I + E + E + E+ E ++ E E K REL K
Sbjct: 294 EEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKM 353
Query: 197 TTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRI 256
+ K R +EEKR+E + + KRQ E+E + W++EEK + ++ + ++ + +
Sbjct: 354 HE------QEKIREQEEKRQEEEKIREQEKRQ-EQEAKMWRQEEKIREQEEKIREQEEMM 406
Query: 257 PERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERASG 316
E+++ E + K+ ++ + ++ EK +E RE+ KK+ ++ +E+
Sbjct: 407 QEQEEKMGEQEEKMWE------QEEEMQEQEEKMRRQEEKIREQEKKIREQ---EEKI-- 455
Query: 317 QSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEEERRRQ 376
R E+ E+ ++ ++ G+ E+E + + +E++ R+ E+++ QE++ R Q
Sbjct: 456 -------REQEEMMQEQEEKMGEQEGK-MCEQEAKMQEQEEKMRRQEEKIREQEKKIREQ 507
Query: 377 KERY-EKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIR 432
+E+ E+E+ + +EE+M ++++ + ++ +K + E EK ++EE ++ +R
Sbjct: 508 EEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQE-----EKMRRQEEKMREQEVR 559
Score = 81.6 bits (200), Expect = 1e-15
Identities = 64/267 (23%), Positives = 144/267 (53%), Gaps = 39/267 (14%)
Query: 205 KNKQRMREEK--REERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPE-RDK 261
+ K + REEK +E + RE E K +R+EE W++EEK +R++ +K ++I E +K
Sbjct: 294 EEKIQEREEKIQEQEEKIREQEEKMRRQEEMM-WEKEEKMRRQEEMMWEKEEKIRELEEK 352
Query: 262 LKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKEL----------DKREKAKKLDKENLSD 311
+ ++ KI+ Q ++ +++ EK E+E ++ EK ++ ++
Sbjct: 353 MHEQEKIREQEEKRQ---EEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQEQ 409
Query: 312 ERASGQSCTLPKRSDSELKDEKPK-RPEDESGRDYREREREYE---RDQERILRERE--- 364
E G+ + E+++++ K R ++E R+ ++ RE E R+QE +++E+E
Sbjct: 410 EEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKM 469
Query: 365 ------------RLKRQEEERRRQKERY-EKEKTFKRKEEEMKKEKDTLRDKGKK--AES 409
+++ QEE+ RRQ+E+ E+EK + +EE+++++++ ++++ +K +
Sbjct: 470 GEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQE 529
Query: 410 TESIGSSEKTEKKEEVVKRDRIRNKDR 436
+ EK +++EE ++R + +++
Sbjct: 530 EKMCEQEEKMQEQEEKMRRQEEKMREQ 556
Score = 79.0 bits (193), Expect = 9e-15
Identities = 60/319 (18%), Positives = 159/319 (49%), Gaps = 35/319 (10%)
Query: 172 EKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREE 231
+++ + + L +E+++ + +L A+ L N+Q+ + R+E + +E E K Q +E
Sbjct: 249 QQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEREEKIQEQE 308
Query: 232 ERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGD 291
E+ + ++EEK +R++ +K +++ ++++ E + K+ EK
Sbjct: 309 EKIR-EQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIREL-------------EEKMH 354
Query: 292 EKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYRERERE 351
E+E + ++ K+ ++E + ++ + R + ++++++ K E E +E+E +
Sbjct: 355 EQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMM--QEQEEK 412
Query: 352 YERDQERILRERERLKRQEEERRRQKERY-EKEKTFKRKEEEMKKEKDTLRD-------- 402
+E++ + E ++ QEE+ RRQ+E+ E+EK + +EE+++++++ +++
Sbjct: 413 MGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQ 472
Query: 403 KGKKAESTESI-GSSEKTEKKEEVVK---------RDRIRNKDRPAMQLYQPGARSRNRL 452
+GK E + EK ++EE ++ ++IR ++ + + ++
Sbjct: 473 EGKMCEQEAKMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKM 532
Query: 453 CPPDDSTKSGDSAAERKQE 471
C ++ + + R++E
Sbjct: 533 CEQEEKMQEQEEKMRRQEE 551
Score = 67.4 bits (163), Expect = 3e-11
Identities = 90/381 (23%), Positives = 172/381 (45%), Gaps = 47/381 (12%)
Query: 135 PFQKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTP--ETLLEEIEAKN--- 189
P A TKK+ GT +PE ++ ++E+ S E L E+EA+
Sbjct: 64 PSVGTAASDTKKKKINNGT---NPETTTSGGCHSPEDEQKASHQHQEALRRELEAQVQTI 120
Query: 190 RELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWK---EEEKRKRKD 246
R L +KT ++ ++ +++ + E R I R WK E E+
Sbjct: 121 RILTCQKTELQMALYYSQHAVKQLEGEARDL--ISRLHD------SWKFAGELEQALSAV 172
Query: 247 IEKLKKIDR-IPERDKLKDEPKIKVHRFLL--QAVNQKNL-------LKKPEKGD----E 292
+ KK DR I E K +D ++++R + + + +KN L + EK +
Sbjct: 173 ATQKKKADRYIEELTKERDALSLELYRNTITDEELKEKNAKLQEKLQLVESEKSEIQLNV 232
Query: 293 KELDKR-EKAKKL--------DKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGR 343
KEL ++ E+AK L + ++L E S + + ++EL + ++ E++
Sbjct: 233 KELKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQVEENELWNRLNQQQEEKM-- 290
Query: 344 DYREREREYERDQERILRERERLKRQEEERRRQKER-YEKEKTFKRKEEEMKKEKDTLRD 402
+R+ E+ ER+ E+I + E+++ QEE+ RRQ+E +EKE+ +R+EE M ++++ +R+
Sbjct: 291 -WRQEEKIQERE-EKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKIRE 348
Query: 403 KGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSG 462
+K E I E+ ++EE ++ R + M + R + +
Sbjct: 349 LEEKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQE 408
Query: 463 DSAAERKQESGISHRKEGGEE 483
+QE + ++E +E
Sbjct: 409 QEEKMGEQEEKMWEQEEEMQE 429
Score = 37.7 bits (86), Expect = 0.023
Identities = 25/136 (18%), Positives = 69/136 (50%), Gaps = 5/136 (3%)
Query: 137 QKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKK 196
+K +++ K R+ + + + + R+ E EKM + E+ EAK +E K
Sbjct: 432 EKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQ-EAKMQEQEEKM 490
Query: 197 TTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRI 256
+ ++++RE++ + R + E+ +E+E + W++EEK ++ + ++ +++
Sbjct: 491 RRQEEKIREQEKKIREQEEKIREQEEM----MQEQEEKMWEQEEKMCEQEEKMQEQEEKM 546
Query: 257 PERDKLKDEPKIKVHR 272
+++ E ++++ +
Sbjct: 547 RRQEEKMREQEVRLRQ 562
>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
Length = 754
Score = 84.7 bits (208), Expect = 2e-16
Identities = 107/446 (23%), Positives = 190/446 (42%), Gaps = 101/446 (22%)
Query: 132 EFAPFQKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNE--KMTSTPETLL--EEIEA 187
E A +K+ K+K K R + + +K +S ++++E + + P++ + EEI
Sbjct: 220 ESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPP 279
Query: 188 --KNRELIAKKTTPLLSFLKNKQRMREEKRE----------------------------E 217
+NR L+ +K+ P + K R RE +RE
Sbjct: 280 IPENRFLM-RKSPPKADEKERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGP 338
Query: 218 RRRREIERKRQREEERRK-----WKEEEKRKRK---------------DIEKLKKIDRIP 257
RR R R R R+ RR W++E +R ++ ++ ++K+ R P
Sbjct: 339 RRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGDKSELNEIKENQRSP 398
Query: 258 ERDKLKDEPKIKVHRFLLQAVNQKNLLKKP---EKGDEKELDKREKAKKLDK-ENLSDER 313
R K E KI HR + ++ N+KN +K K + KE D R ++K DK +N +R
Sbjct: 399 VRVK---ERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKR 455
Query: 314 ASGQSCTLPK-RSDSELKDEKPKRPEDE------SGRDYRE-REREYERDQERILRERER 365
A +S + K +S S+ +D K R E++ GRD+ +E+E + D + +ER R
Sbjct: 456 AKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQERSR 515
Query: 366 LKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEV 425
K + ++ + ++ K+ ++ + ++ KGK + ++ + S ++ V
Sbjct: 516 SKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRV 575
Query: 426 VKRDRIRNKDRPAMQLY----------QPGARSRNRLCPPD------------------- 456
R R ++DR + Y + +RSR R PP
Sbjct: 576 --RSRTHDRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRSRSKDRRRRRRDSRSSER 633
Query: 457 DSTKSGDSAAERKQESGISHRKEGGE 482
+ ++S + R QES SHRKE E
Sbjct: 634 EESQSRNKDKYRNQESKSSHRKENSE 659
Score = 73.6 bits (179), Expect = 4e-13
Identities = 54/303 (17%), Positives = 131/303 (43%), Gaps = 4/303 (1%)
Query: 170 DNEKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQR 229
D ++ E + K R++ + KN++ + + + + R+
Sbjct: 384 DKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSE 443
Query: 230 EEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEK 289
++++ K K +++ K K K K+ + ERD + + K R + + +N+ +K ++
Sbjct: 444 KDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEKQ 503
Query: 290 GDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYRERE 349
D K D +E+++ +K + +++ + K D + + + Y R
Sbjct: 504 SDSKGKD-QERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRT 562
Query: 350 REYERDQERILRERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAES 409
RE R ++R R R R ++ R ++ RY +E+ ++R+ +E+ T + + +
Sbjct: 563 RERSRSRDRSRRVRSRTHDRDRSRSKEYHRY-REQEYRRRGRSRSRERRTPPGRSRSKDR 621
Query: 410 TESIGSSEKTEKKEEVVK-RDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAER 468
S +E++E + +D+ RN++ + + + S R+ S +++ E+
Sbjct: 622 RRRRRDSRSSEREESQSRNKDKYRNQESKSSH-RKENSESEKRMYSKSRDHNSSNNSREK 680
Query: 469 KQE 471
K +
Sbjct: 681 KAD 683
Score = 63.2 bits (152), Expect = 5e-10
Identities = 67/303 (22%), Positives = 134/303 (44%), Gaps = 24/303 (7%)
Query: 138 KAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKKT 197
K K +K+RD + + DD +Y+ ++ A + S ++ +E ++K+ K+
Sbjct: 427 KDHKSNSKERDIRRNSEKDD-KYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRM 485
Query: 198 TPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIP 257
++ +EK+ + + ++ ER R +E+ ++ E K D K K+ DR
Sbjct: 486 RSRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQL---ESKSNEHDHSKSKEKDRRA 542
Query: 258 E-RDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDK-REKAKKLDKENLSDERAS 315
+ R + D K K H + + + + + + D+ R ++K+ + + R
Sbjct: 543 QSRSRECDITKGK-HSYNSRTRERSRSRDRSRRVRSRTHDRDRSRSKEYHRYREQEYRRR 601
Query: 316 GQSCTLPKRSD---SELKDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEEE 372
G+S + +R+ S KD + +R RD R ERE E R +++ + QE +
Sbjct: 602 GRSRSRERRTPPGRSRSKDRRRRR------RDSRSSERE-----ESQSRNKDKYRNQESK 650
Query: 373 RRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIR 432
+KE E EK K + ++ + KKA+ +S S K ++ +K ++
Sbjct: 651 SSHRKENSESEKRMYSKSRDHNSSNNS---REKKADRDQSPFSKIKQSSQDNELKSSMLK 707
Query: 433 NKD 435
NK+
Sbjct: 708 NKE 710
Score = 51.2 bits (121), Expect = 2e-06
Identities = 57/241 (23%), Positives = 97/241 (40%), Gaps = 33/241 (13%)
Query: 141 KKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNREL-IAKKTTP 199
K+K K+ D+K + K + + NE S + ++++RE I K
Sbjct: 498 KEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRSRECDITKGKHS 557
Query: 200 LLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKR--------------- 244
S + + R R+ R R R +R R R +E +++E+E R+R
Sbjct: 558 YNSRTRERSRSRDRSRRVRSRTH-DRDRSRSKEYHRYREQEYRRRGRSRSRERRTPPGRS 616
Query: 245 --KDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELD------ 296
KD + ++ R ER++ + K K ++ ++K + ++ K D
Sbjct: 617 RSKDRRRRRRDSRSSEREESQSRNKDKYRNQESKSSHRKENSESEKRMYSKSRDHNSSNN 676
Query: 297 KREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQ 356
REK D+ S + S Q D+ELK K EDE R E+E + + Q
Sbjct: 677 SREKKADRDQSPFSKIKQSSQ--------DNELKSSMLKNKEDEKIRSSVEKENQKSKGQ 728
Query: 357 E 357
E
Sbjct: 729 E 729
Score = 50.4 bits (119), Expect = 3e-06
Identities = 75/320 (23%), Positives = 131/320 (40%), Gaps = 68/320 (21%)
Query: 223 IERKRQREEERRKWK-------------------------------EEEKRKR------- 244
I + + ++EE+++ K EE+ +KR
Sbjct: 178 IPKSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKKKHRKN 237
Query: 245 -----KDIEKLKKIDRI----PERDKLKDEPKIKVHRFLLQAVNQKNLL--KKPEKGDEK 293
K+ +K KK + E + L+ +P+ V + + + L K P K DEK
Sbjct: 238 SRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADEK 297
Query: 294 ELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYE 353
E RE+ ++ + + + AS Q L RS ++K P+R S R R R+
Sbjct: 298 ERKNRERERERECNPPNSQPASYQRRLLVTRSGRKIKGRGPRRYRTPS----RSRSRDRF 353
Query: 354 RDQERILRERERLKRQEEERRRQKERYEKEKTFKRKEEEMKK-EKDTLRDKGKKAESTES 412
R E R+ ++R + R ER+ K K + E+K+ ++ +R K +K +
Sbjct: 354 RRSETPPHWRQEMQRAQRMRVSSGERWIKGD--KSELNEIKENQRSPVRVKERKITDHRN 411
Query: 413 IGSS--EKTEKKEEV-------VKRDRIRN--KDRPAMQLYQPGARSRNRLCPPDDS-TK 460
+ S K EK+++V +RD RN KD + A+S++R + S +K
Sbjct: 412 VSESPNRKNEKEKKVKDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSK 471
Query: 461 SGDSAAERKQESGISHRKEG 480
DS R +E + R +G
Sbjct: 472 ERDSKHNRNEEKRMRSRSKG 491
>gi|239745089 PREDICTED: golgi autoantigen, golgin subfamily a-like
[Homo sapiens]
Length = 828
Score = 84.3 bits (207), Expect = 2e-16
Identities = 69/310 (22%), Positives = 154/310 (49%), Gaps = 22/310 (7%)
Query: 137 QKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKK 196
+K +++ + R+ + + + E R+ + + E+ E + E E K RE K
Sbjct: 276 EKMRRQEKRLREQEKELREQEKELRE--QKKLREQEEQMQEQEEKMWEQEEKMREQEEKM 333
Query: 197 TTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDI----EKLKK 252
+ +++MRE+ E++ R+ E + ++ER + KEE R+++ + EK+++
Sbjct: 334 WRQEERLWEQEKQMREQ---EQKMRDQEERMWEQDERLREKEERMREQEKMWEQEEKMQE 390
Query: 253 IDRIPERDK-LKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSD 311
+RI ER+K +++E + + ++N+ ++ EK +++ +K K ++E + +
Sbjct: 391 EERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQE 450
Query: 312 ERASGQSCTLPKRSDSEL--------KDEKPKRPED---ESGRDYREREREYERDQERIL 360
+ R E+ + EK + ED E R++E++ +ER+
Sbjct: 451 QEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMW 510
Query: 361 RERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTE 420
+ ERL+ +EE R QK+ +++E+ + +++ ++EK T D+ +K E + EK
Sbjct: 511 EQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTW-DQEEKMREEERMREREKKM 569
Query: 421 KKEEVVKRDR 430
++EE + R++
Sbjct: 570 REEEEMMREQ 579
Score = 83.2 bits (204), Expect = 5e-16
Identities = 81/305 (26%), Positives = 153/305 (50%), Gaps = 23/305 (7%)
Query: 137 QKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKK 196
+K +++ K R+ + + + + + E EKM E L E+ E + RE K
Sbjct: 296 EKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQ-EKQMREQEQKM 354
Query: 197 TTPLLSFLKNKQRMREEK---REERRRREIERKRQREEERR----KWKEEEKRKRKDIEK 249
+ +R+RE++ RE+ + E E K Q EE R K +EEE+ R+ EK
Sbjct: 355 RDQEERMWEQDERLREKEERMREQEKMWEQEEKMQEEERIREREKKMREEEETMREQEEK 414
Query: 250 LKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKL-DKEN 308
++K E + + E K + L + QK L + EK E+E E+ +K+ D+E
Sbjct: 415 MQK----QEENMWEQEEKEWQQQRLPE---QKEKLWEQEKMQEQEEKIWEQEEKIRDQEE 467
Query: 309 L-SDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYE---RDQERILRERE 364
+ E+ + + ++ D + E+ R +++ D ER E + R++E +RE++
Sbjct: 468 MWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQK 527
Query: 365 RLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESI--GSSEKTEKK 422
++ +QEE+ R +K+ E+EK +EE+M +E++ +R++ KK E + EK +++
Sbjct: 528 KMWQQEEKMREEKKTQEQEKKTWDQEEKM-REEERMREREKKMREEEEMMREQEEKMQEQ 586
Query: 423 EEVVK 427
EE ++
Sbjct: 587 EEKMR 591
Score = 83.2 bits (204), Expect = 5e-16
Identities = 70/347 (20%), Positives = 173/347 (49%), Gaps = 15/347 (4%)
Query: 141 KKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKKTTPL 200
+++ K RD + + D R+ E + EKM E + EE + RE ++
Sbjct: 349 EQEQKMRDQEERMWEQDERLRE-KEERMREQEKMWEQEEKMQEEERIREREKKMREEEET 407
Query: 201 LSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERD 260
+ + K + +EE E+ +E +++R E++ + W E+EK + ++ + ++ ++I +++
Sbjct: 408 MREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLW-EQEKMQEQEEKIWEQEEKIRDQE 466
Query: 261 KLKDEPKIKVHRFLLQAVNQKNLLKKPEK---GDEKELDKREKAKKLDKENLSDERASGQ 317
++ + K K+ R + + ++ EK ++K D+ E+ + D E L ++ +
Sbjct: 467 EMWGQEK-KMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQD-ERLREKEERMR 524
Query: 318 SCTLPKRSDSELKDEKPKRPEDESGRDYREREREYER--DQERILRERERLKRQEEERRR 375
+ + ++++EK + +++ D E+ RE ER ++E+ +RE E + R++EE+ +
Sbjct: 525 EQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQ 584
Query: 376 QKER--YEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVV-KRDRIR 432
++E E+E+ +EE+M+++++ + ++ +K E +K +++EE++ +++
Sbjct: 585 EQEEKMREQEEKMWEQEEKMQEQEEKMWEQEEKMWEQE---EEDKMQEQEEMMWEQEEKM 641
Query: 433 NKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQESGISHRKE 479
+ M + R + + G R+QE + ++E
Sbjct: 642 QEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEE 688
Score = 83.2 bits (204), Expect = 5e-16
Identities = 47/228 (20%), Positives = 126/228 (55%), Gaps = 5/228 (2%)
Query: 205 KNKQRMREEK-REERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLK 263
+ K+ R+EK RE+ + + ++ R++E++ W +EE+ +D +K +R+ E+ K+
Sbjct: 471 QEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMW 530
Query: 264 DEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERASGQSCTLPK 323
+ + Q +K ++ + +E+ + +REK + ++E + ++ Q
Sbjct: 531 QQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKM 590
Query: 324 RSDSELKDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEEERRRQKER--YE 381
R E E+ ++ +++ + + + E+ +E+++E ++E+E + ++EE+ +++E +E
Sbjct: 591 REQEEKMWEQEEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWE 650
Query: 382 KEKTFKRKEEEMKKEKDTLRDKGKKAESTES--IGSSEKTEKKEEVVK 427
+E+ + +EE+M+++++ ++ + +K E G EK ++EE ++
Sbjct: 651 QEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMR 698
Score = 81.3 bits (199), Expect = 2e-15
Identities = 65/296 (21%), Positives = 151/296 (51%), Gaps = 30/296 (10%)
Query: 172 EKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREE 231
EKM + + E+ E K R+ K + +R+RE++ R ++++ ++ ++
Sbjct: 479 EKMREQEDQMWEQ-EEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMR 537
Query: 232 ERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGD 291
E +K +E+EK+ EK+++ +R+ ER+K E ++ + ++ EK
Sbjct: 538 EEKKTQEQEKKTWDQEEKMREEERMREREKKMRE-------------EEEMMREQEEKMQ 584
Query: 292 EKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYRERERE 351
E+E RE+ +K+ ++ +E+ Q + ++ + + E+ + +++ + E+E +
Sbjct: 585 EQEEKMREQEEKMWEQ---EEKMQEQEEKMWEQEEKMWEQEEEDKMQEQEEMMW-EQEEK 640
Query: 352 YERDQERILRERERLKRQEEERRRQKERYE-KEKTFKRKEEEMKKEKDTLRDKGKKAEST 410
+ +E++ + E+++ QEE+ R Q+E+ + +E+ + +EE+M+ +++ +R++ +K
Sbjct: 641 MQEQEEKMWEQEEKMREQEEKMREQEEKMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQ 700
Query: 411 ESI---------GSSEKTEKKEEV-VKRDRIRN-KDRPAMQLYQPGARSRNRLCPP 455
E G EK +EE+ K +RIR+ K++ +L + R PP
Sbjct: 701 EEKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQERLPEHEERCSEPCLPP 756
Score = 80.1 bits (196), Expect = 4e-15
Identities = 76/367 (20%), Positives = 183/367 (49%), Gaps = 31/367 (8%)
Query: 141 KKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLE---EIEAKNRELIAKKT 197
+KK +K++ K+ ++ R+ EKM + L E E+ + +EL +K
Sbjct: 247 EKKIRKQEEKMWRQEE--RLREQEGKMREQEEKMRRQEKRLREQEKELREQEKELREQKK 304
Query: 198 TPLLSFLKNKQRMREEK--REERRRREIERKRQREEER-----RKWKEEEKRKRKDIEKL 250
L + + + +EEK +E + RE E K R+EER ++ +E+E++ R E++
Sbjct: 305 ---LREQEEQMQEQEEKMWEQEEKMREQEEKMWRQEERLWEQEKQMREQEQKMRDQEERM 361
Query: 251 -KKIDRIPER-DKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDK-- 306
++ +R+ E+ ++++++ K+ +Q ++ + ++ +K E+E RE+ +K+ K
Sbjct: 362 WEQDERLREKEERMREQEKMWEQEEKMQ--EEERIREREKKMREEEETMREQEEKMQKQE 419
Query: 307 ENL-SDERASGQSCTLPKRSDSELKDEKPKRPED---ESGRDYREREREYERD-----QE 357
EN+ E Q LP++ + + EK + E+ E R++E + ++ QE
Sbjct: 420 ENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEKIWEQEEKIRDQEEMWGQEKKMWRQE 479
Query: 358 RILRERERLKRQEEERRRQKER-YEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSS 416
++ + +++ QEE+ R Q+++ +++E+ ++E ++++++ +R++ K + E +
Sbjct: 480 KMREQEDQMWEQEEKMRDQEQKMWDQEERMWEQDERLREKEERMREQKKMWQQEEKMREE 539
Query: 417 EKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQESGISH 476
+KT+++E+ + ++ M+ + R + + R+QE +
Sbjct: 540 KKTQEQEKKTWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWE 599
Query: 477 RKEGGEE 483
++E +E
Sbjct: 600 QEEKMQE 606
Score = 79.0 bits (193), Expect = 9e-15
Identities = 79/359 (22%), Positives = 168/359 (46%), Gaps = 47/359 (13%)
Query: 159 EYRKFLESYATDN---EKMTSTPETLLEEIEAKNRELIAK--KTTPLLSFLKNKQRMREE 213
E KFL N E+M E L E+ E K R+ K + L + K R +EE
Sbjct: 218 ERAKFLLPQVQTNTLQEEMWRQEEELREQ-EKKIRKQEEKMWRQEERLREQEGKMREQEE 276
Query: 214 K--REERRRREIERK-RQREEERRK------------------WKEEEKRKRKDIEKLKK 252
K R+E+R RE E++ R++E+E R+ W++EEK + ++ + ++
Sbjct: 277 KMRRQEKRLREQEKELREQEKELREQKKLREQEEQMQEQEEKMWEQEEKMREQEEKMWRQ 336
Query: 253 IDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDE 312
+R+ E++K E + K+ ++ + ++ E+ EKE RE+ K ++E E
Sbjct: 337 EERLWEQEKQMREQEQKMRD------QEERMWEQDERLREKEERMREQEKMWEQEEKMQE 390
Query: 313 RASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEEE 372
+ R + E E+ ++ + + + + E+E++ Q+R+ ++E+L QE+
Sbjct: 391 EERIREREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQ--QQRLPEQKEKLWEQEKM 448
Query: 373 RRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVV------ 426
+ ++++ +E+E+ + +EE +EK R + + + + EK +E+ +
Sbjct: 449 QEQEEKIWEQEEKIRDQEEMWGQEKKMWRQEKMREQEDQMWEQEEKMRDQEQKMWDQEER 508
Query: 427 ---KRDRIRNKD---RPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQESGISHRKE 479
+ +R+R K+ R +++Q + R + K+ D + ++E + R++
Sbjct: 509 MWEQDERLREKEERMREQKKMWQQEEKMREEKKTQEQEKKTWDQEEKMREEERMREREK 567
Score = 78.2 bits (191), Expect = 2e-14
Identities = 68/306 (22%), Positives = 151/306 (49%), Gaps = 37/306 (12%)
Query: 183 EEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRR----EIERKRQREE---ERRK 235
EE++ KN EL K + + ++E KR+ R + +++ +EE + +
Sbjct: 183 EELKKKNAELQEKLRLAESEKSEIQLNVKELKRKLERAKFLLPQVQTNTLQEEMWRQEEE 242
Query: 236 WKEEEKRKRKDIEKL-KKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKE 294
+E+EK+ RK EK+ ++ +R+ E++ E + K+ R +K L ++ ++ E+E
Sbjct: 243 LREQEKKIRKQEEKMWRQEERLREQEGKMREQEEKMRR------QEKRLREQEKELREQE 296
Query: 295 LDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYER 354
+ RE+ K ++E ++++++ K E E RE+E + R
Sbjct: 297 KELREQKKLREQEE-------------------QMQEQEEKMWEQEE--KMREQEEKMWR 335
Query: 355 DQERILRERERLKRQEEERRRQKER-YEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESI 413
+ER+ + ++++ QE++ R Q+ER +E+++ + KEE M +E++ + ++ +K + E I
Sbjct: 336 QEERLWEQEKQMREQEQKMRDQEERMWEQDERLREKEERM-REQEKMWEQEEKMQEEERI 394
Query: 414 GSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQESG 473
EK ++EE R++ + +++ + + P+ K + ++QE
Sbjct: 395 REREKKMREEEETMREQEEKMQKQEENMWEQEEKEWQQQRLPEQKEKLWEQEKMQEQEEK 454
Query: 474 ISHRKE 479
I ++E
Sbjct: 455 IWEQEE 460
Score = 73.9 bits (180), Expect = 3e-13
Identities = 67/280 (23%), Positives = 138/280 (49%), Gaps = 44/280 (15%)
Query: 137 QKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKK 196
+K ++ K D + + D R+ E + +KM E + EE + + +E KK
Sbjct: 493 EKMRDQEQKMWDQEERMWEQDERLRE-KEERMREQKKMWQQEEKMREEKKTQEQE---KK 548
Query: 197 TTPLLSFLKNKQRMREEKR----EERRRREIERKRQ------REEERRKWKEEEK---RK 243
T ++ ++RMRE ++ EE RE E K Q RE+E + W++EEK ++
Sbjct: 549 TWDQEEKMREEERMREREKKMREEEEMMREQEEKMQEQEEKMREQEEKMWEQEEKMQEQE 608
Query: 244 RKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKK 303
K E+ +K+ E DK++++ ++ + ++ + ++ EK E+E RE+ +K
Sbjct: 609 EKMWEQEEKMWEQEEEDKMQEQEEMMWEQ-------EEKMQEQEEKMWEQEEKMREQEEK 661
Query: 304 LDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRER 363
+ ++ +E+ GQ E+ R ++E + E+ RE E E++ +
Sbjct: 662 MREQ---EEKMQGQ--------------EEKMREQEEKMQGQEEKMREQE---EKMRGQE 701
Query: 364 ERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDK 403
E++ QEE+ Q+E+ ++ + KEE ++ +K+ ++++
Sbjct: 702 EKMWGQEEKMWGQEEKMWGQEEMREKEERIRDQKEKMQER 741
Score = 40.8 bits (94), Expect = 0.003
Identities = 34/145 (23%), Positives = 71/145 (48%), Gaps = 19/145 (13%)
Query: 141 KKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEA-KNRELIAKKTTP 199
++K +++ K+ +++ + ++ E EKM E + E+ E + +E ++
Sbjct: 608 EEKMWEQEEKMWEQEEEDKMQEQEEMMWEQEEKMQEQEEKMWEQEEKMREQEEKMREQEE 667
Query: 200 LLSFLKNKQRMREEK---REERRRREIERKRQREE------------ERRKWKEEEKRKR 244
+ + K R +EEK +EE+ R + E+ R +EE E + W +EE R++
Sbjct: 668 KMQGQEEKMREQEEKMQGQEEKMREQEEKMRGQEEKMWGQEEKMWGQEEKMWGQEEMREK 727
Query: 245 KD---IEKLKKIDRIPERDKLKDEP 266
++ +K K +R+PE ++ EP
Sbjct: 728 EERIRDQKEKMQERLPEHEERCSEP 752
>gi|221219020 NYD-SP11 protein [Homo sapiens]
Length = 2873
Score = 82.4 bits (202), Expect = 8e-16
Identities = 76/308 (24%), Positives = 158/308 (51%), Gaps = 28/308 (9%)
Query: 138 KAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEA---KNRELIA 194
KA++K KKR++ + K L+ D K+T + + A K R L
Sbjct: 2054 KASRKLIKKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSI 2113
Query: 195 KKTTPLLSFL----KNKQRMREEKREERRRREIERKRQR--EEERRKWKEEEKRKRKDIE 248
+++ + K + ++EK+ R++R++ K +R +E + +EE K RK E
Sbjct: 2114 EQSKLDIKEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSE 2173
Query: 249 KLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEK---ELDKREKAKKLD 305
+ + E +++E I FL + ++ K+ +K EK ++D+ E +
Sbjct: 2174 VILDDE---EEGGIEEEEVIP---FLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFS 2227
Query: 306 KE--NLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRER 363
+E +L DE +S + + E ++E+ +R E+E + ER+ E E +++++ +E
Sbjct: 2228 EEMESLLDELEKQESLS---SEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEE 2284
Query: 364 ERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEK-DTLRDKGKKAESTESIGSSEKTEKK 422
E K++++E++++ E EKE+ F+ KEE M +E+ ++L D + E ES E+ +++
Sbjct: 2285 EEKKKKKKEKKKE-EVQEKEEVFEEKEEIMSEEETESLSD---EEEEEESCSLEEEVDRE 2340
Query: 423 EEVVKRDR 430
+E++K+++
Sbjct: 2341 KEILKKEK 2348
Score = 72.0 bits (175), Expect = 1e-12
Identities = 78/293 (26%), Positives = 133/293 (45%), Gaps = 49/293 (16%)
Query: 188 KNRELIAKKTTPLLSFLKNKQRMREEKR----EERRRREIERKRQREEER---------- 233
K RE ++K+ L LK Q++ ++R EE + +++R +E R
Sbjct: 2061 KKRESLSKEPAKLNKILKALQKLTRDERKLTQEEIKMTKMKRALFVKERRLSIEQSKLDI 2120
Query: 234 RKWKEEEKRKR--KDIEKLKKIDRI---PERDKLKDEPKIKVHRFLLQAVNQKNLLKKPE 288
++W EKR KD +KL + R R + E K+ L + + +L E
Sbjct: 2121 KEWDFSEKRSELTKDEKKLARKQRKLANKMRRMINKEEKMTEEESKLARKHSEVILDDEE 2180
Query: 289 KGDEKELD----------KREKAKKLDK--ENLSDERASGQSCTLPKRSDSELKDEKPKR 336
+G +E + KR++AK+ DK E S + +S L DE K+
Sbjct: 2181 EGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQ 2240
Query: 337 PEDESGRDYREREREYERDQERILRERERLKRQEE---------ERRRQKERYEKEKTFK 387
E S + ERE E ER++E + E E K +EE E ++K++ EK+K
Sbjct: 2241 -ESLSSEEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEV 2299
Query: 388 RKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEK----KEEVVKRDRIRNKDR 436
+++EE+ +EK+ + + E TES+ E+ E+ +EEV + I K++
Sbjct: 2300 QEKEEVFEEKEEIMSE----EETESLSDEEEEEESCSLEEEVDREKEILKKEK 2348
Score = 67.0 bits (162), Expect = 4e-11
Identities = 54/226 (23%), Positives = 107/226 (47%), Gaps = 25/226 (11%)
Query: 187 AKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREI----ERKRQREEE------RRKW 236
A+ + +A K +++ K ++ EE + R+ E+ E + EEE +R+W
Sbjct: 2140 ARKQRKLANKMRRMIN--KEEKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRW 2197
Query: 237 KEEEKRKRKDIEKLK---KIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEK 293
++ ++ KR D K K ++D + + +E + LL + ++ L E+ + +
Sbjct: 2198 RKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMES-----LLDELEKQESLSSEEEEERE 2252
Query: 294 ELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPED--ESGRDYRERERE 351
E ++RE+ + ++E E G+ + K + + K +K K+ E+ E + E+E
Sbjct: 2253 EEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEI 2312
Query: 352 YERDQERILRERERLKRQ---EEERRRQKERYEKEKTFKRKEEEMK 394
++ L + E + EEE R+KE +KEK FK +E+ K
Sbjct: 2313 MSEEETESLSDEEEEEESCSLEEEVDREKEILKKEKQFKLQEQRRK 2358
Score = 63.5 bits (153), Expect = 4e-10
Identities = 88/355 (24%), Positives = 164/355 (46%), Gaps = 65/355 (18%)
Query: 160 YRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKR---E 216
+ L S + + + TL EE+ + E +Q++ EE+R E
Sbjct: 1525 WENMLSSKSKEQQYKDEEEVTLEEEVSREGEE--------------KEQQVTEEQRHIQE 1570
Query: 217 ERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDR-IPERDKLKDEPKIKV---HR 272
E + I RKR R E++R +EE++ ++ EKL + +R + + ++ + +K+ R
Sbjct: 1571 EHKWARIHRKRARAEKKRA--QEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDR 1628
Query: 273 FLLQAVN-----QKNLLKKPEKGD---EKELDKREK-AKKLDKENLSDERASGQSCTLPK 323
+ QA ++ L ++ EK EK KR+K AKK +K +E+ + + L +
Sbjct: 1629 EMAQAEGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKLAKKGGKLAE 1688
Query: 324 RSDSELKDEKPKRPEDESGRDYRERE-----------------REYERDQE--RILRERE 364
+ L + + P+ E D++E+E +E E +QE +++ E++
Sbjct: 1689 VKNI-LAQKVEELPQREQNLDWQEKELAQELEELEWDMEELSWKEEELNQEEGKLVEEKK 1747
Query: 365 RLKRQEEERRRQKERYEKEKTFKRKEEEMK-KEKDTL-RDKGKKAESTESIGSSEK--TE 420
+L +EE Q+E+ +E+T +EEE+ +EK+ L + K K E E +G + E
Sbjct: 1748 KLAEEEEALAWQREKLSEEETKLAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIE 1807
Query: 421 KKEEVV-KRDRIRNK----DRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQ 470
KK ++ KR+R N + M LYQ +N + + + A+RK+
Sbjct: 1808 KKMKLAQKRERWINSMEELTKNKMILYQ----KKNLAQEKKNLAQEKEKLAQRKE 1858
Score = 62.4 bits (150), Expect = 9e-10
Identities = 67/296 (22%), Positives = 131/296 (44%), Gaps = 31/296 (10%)
Query: 172 EKMTSTPETLLE---EIEAKNRELIAKKTTPLLSFLKNKQRMREE-KREERRRREIERKR 227
EKMT L E+ + E + ++ FLK + R R+E KR ++ + + +
Sbjct: 2158 EKMTEEESKLARKHSEVILDDEEEGGIEEEEVIPFLKRRWRKRKEAKRGDKPKEKFSSQV 2217
Query: 228 QREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKP 287
E + EE + ++EK + + E ++ ++E + + + ++ K+
Sbjct: 2218 DEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEE-----EVREEEEERKEE 2272
Query: 288 EKGDEKELDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYRE 347
E+G+EK+++K E+ KK K+ E + ++ + ++E ++E +
Sbjct: 2273 EEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIMSEEETESLSDEEEEEESCS 2332
Query: 348 REREYERDQERILRERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEK---DTLRDKG 404
E E +R++E IL++ ++ K QE+ R+ + R E+ + R K L+
Sbjct: 2333 LEEEVDREKE-ILKKEKQFKLQEQRRKSLRGR-ERVLSILRGVPHGKGRAIRLGVLKSPL 2390
Query: 405 KKAESTESIGSSEKT------------EKKEEVVKRDR----IRNKDRPAMQLYQP 444
KK ST ++ EKT +KK VV+ R +K+R M Y+P
Sbjct: 2391 KKLMST-ALEMKEKTPVPVPEKQISWEDKKATVVEIPRKFLGTMDKEREVMGKYEP 2445
Score = 58.5 bits (140), Expect = 1e-08
Identities = 68/303 (22%), Positives = 138/303 (45%), Gaps = 42/303 (13%)
Query: 202 SFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEE-----KRKRKDIEKLKKIDRI 256
+F K+ ++ R+ ++ER+ +I+R+ +EE + EE ++ K KL I+R
Sbjct: 1395 TFQKSPKQGRKAVQKERKVGKIKREMTKEERDMSEEVEEMATLEEKVVKQEGKLVMIERT 1454
Query: 257 PERDKLK---DEPKIKVHRFLLQAVN------QKNLLKKPEKGDE--KELDKREKAKKLD 305
P K DE K +VH ++ +K LL++ EK + ++L E+ + D
Sbjct: 1455 PSWQDWKKAWDEWK-QVHGETRKSWKAWKEEWEKRLLQEEEKLHQAGEKLSPEEEMLQED 1513
Query: 306 KENLSDE-RASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRERE 364
K+ +E + ++ K + + KDE+ E+E R+ E+E++ +Q I E +
Sbjct: 1514 KKLKWEEWKQVWENMLSSKSKEQQYKDEEEVTLEEEVSREGEEKEQQVTEEQRHIQEEHK 1573
Query: 365 RLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKK---------AESTESIGS 415
+ + R +K+R ++E+ ++EE++ +E+ L + +K + E +
Sbjct: 1574 WARIHRKRARAEKKRAQEERKLAQEEEKLAQEERQLAQEERKLAQAYVKITQDDREMAQA 1633
Query: 416 SEKTEKKEEVV---------KRDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAA 466
K +KEE + + +++ K + + ++ AR +L K G A
Sbjct: 1634 EGKFAQKEETLAQRGEKLSQEAEKLAQKRKKLAKKWEKVAREEEKL------AKKGGKLA 1687
Query: 467 ERK 469
E K
Sbjct: 1688 EVK 1690
Score = 57.4 bits (137), Expect = 3e-08
Identities = 75/356 (21%), Positives = 149/356 (41%), Gaps = 23/356 (6%)
Query: 131 VEFAPFQKAAKKKTKK-RDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKN 189
++ A +KA + K+ + K+ ++ K + KMT + L E +
Sbjct: 1954 LDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFERKLSLE 2013
Query: 190 RELIAKKTTPLL----SFLKNKQRMREEKR--EERRRREIERKRQREEERRKWKEEEKRK 243
+++ + L K K +R + +R+ + R+ ++R +E +
Sbjct: 2014 EKILLHEDRILAMEESEIAKGKLEFTRGQRIFVQGQRKLAKASRKLIKKRESLSKEPAKL 2073
Query: 244 RKDIEKLKKIDRIPERDKLKDEPKI-KVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAK 302
K ++ L+K+ R ER ++E K+ K+ R L V ++ L + K D KE D EK
Sbjct: 2074 NKILKALQKLTR-DERKLTQEEIKMTKMKRALF--VKERRLSIEQSKLDIKEWDFSEKRS 2130
Query: 303 KLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYRE----REREYERDQER 358
+L K+ R + +R + K+EK E + R + E E E ++E
Sbjct: 2131 ELTKDEKKLARKQRKLANKMRRMIN--KEEKMTEEESKLARKHSEVILDDEEEGGIEEEE 2188
Query: 359 I---LRERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGS 415
+ L+ R R +++ + + KE++ + EE +E ++L D+ E ES+ S
Sbjct: 2189 VIPFLKRRWRKRKEAKRGDKPKEKFSSQVDEVESEEHFSEEMESLLDE---LEKQESLSS 2245
Query: 416 SEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQE 471
E+ E++EE + + ++ + + G + + K + E QE
Sbjct: 2246 EEEEEREEEEEREEEEVREEEEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQE 2301
Score = 48.9 bits (115), Expect = 1e-05
Identities = 39/173 (22%), Positives = 83/173 (47%), Gaps = 24/173 (13%)
Query: 138 KAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEK---MTSTPETLLEEIEAKNRELIA 194
K K +K ++V ++ + + + +ES + EK ++S E EE E + E +
Sbjct: 2204 KRGDKPKEKFSSQVDEVESEEHFSEEMESLLDELEKQESLSSEEEEEREEEEEREEEEVR 2263
Query: 195 KKTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKID 254
++ ++ +EE+ E ++ E E + ++++++ K KEE + K + E+ ++I
Sbjct: 2264 EE----------EEERKEEEEGEEKQVEKEEEEKKKKKKEKKKEEVQEKEEVFEEKEEIM 2313
Query: 255 RIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKE 307
E + L DE + +++ + E EKE+ K+EK KL ++
Sbjct: 2314 SEEETESLSDEEE-----------EEESCSLEEEVDREKEILKKEKQFKLQEQ 2355
Score = 47.8 bits (112), Expect = 2e-05
Identities = 64/300 (21%), Positives = 134/300 (44%), Gaps = 16/300 (5%)
Query: 157 DPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKRE 216
+ E + LE D E+++ E L +E E K E K + ++++ EE+ +
Sbjct: 1711 EKELAQELEELEWDMEELSWKEEELNQE-EGKLVEEKKKLAEEEEALAWQREKLSEEETK 1769
Query: 217 ERRRRE--IERKRQREEERRKWKEEEKR---KRKD-IEKLKKIDRIPERDKLKDEPKIKV 270
+ E I+ K + + + K EEE+R KR+ IEK K+ + ER E K
Sbjct: 1770 LAQEEELLIQEKEKLAQHKEKMPEEEERLGRKREQLIEKKMKLAQKRERWINSMEELTKN 1829
Query: 271 HRFLLQAVN----QKNLLKKPEKGDEKE---LDKREKAKKLDKENLSDERASGQSCTLPK 323
L Q N +KNL ++ EK +++ L +E+ K+ + + G +
Sbjct: 1830 KMILYQKKNLAQEKKNLAQEKEKLAQRKENLLYNKERLTHSKKQLVQVKNKLGMFNKILA 1889
Query: 324 RSDSELKDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQEEERRRQKERYEKE 383
+ + +L EK + + E E++ + ++ + +++E+L +++ + +K + +
Sbjct: 1890 QVEEKLTQEKETVIKKKE--KLAETEKKLVQVEDSLAKKQEKLAQEKMKLALEKAMVQGK 1947
Query: 384 KTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQ 443
K + + + K+EK + + AE + ++T K E + R R + +L++
Sbjct: 1948 KRLRGELDIAKEEKALNLEMKRLAEEKMRLVEGKETLSKGETPETSRQRKMTQVEQELFE 2007
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 82.0 bits (201), Expect = 1e-15
Identities = 70/311 (22%), Positives = 144/311 (46%), Gaps = 49/311 (15%)
Query: 175 TSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERR 234
T+TP LE+++ + AK L + + MR ++ EE R+R+ E +RQ+EE R
Sbjct: 710 TTTPGPALEQLQQLEKAKAAK-----LEQERREAEMRAKREEEERKRQEELRRQQEEILR 764
Query: 235 KWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKE 294
+ +EEE+++R++ E ++ K E ++ R ++ + + ++ +E+
Sbjct: 765 RQQEEERKRREEEELARR----------KQEEALRRQR-------EQEIALRRQREEEER 807
Query: 295 LDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYER 354
+ E ++L++ +E Q L K+ E + K R E+E+ R E E
Sbjct: 808 QQQEEALRRLEERRREEEERRKQEELLRKQ---EEEAAKWAREEEEAQRRLEENRLRMEE 864
Query: 355 DQERILRERERLKRQEEERRRQKE----RYEKEKTFKRKEEEMKKEK------------- 397
+ R+ E E KR+E E +RQKE R ++++ +R +++ ++++
Sbjct: 865 EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 924
Query: 398 DTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNR------ 451
++++T S+ +K E++ E R+ R + R M+ Q + + +
Sbjct: 925 QQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWG 984
Query: 452 -LCPPDDSTKS 461
+ P +TKS
Sbjct: 985 NVSKPSGTTKS 995
Score = 49.7 bits (117), Expect = 6e-06
Identities = 46/204 (22%), Positives = 94/204 (46%), Gaps = 33/204 (16%)
Query: 172 EKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQR-E 230
E+ E L +E + RE ++ L + ++ + + EE +R +E R R E
Sbjct: 804 EEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRME 863
Query: 231 EERRKWK-EEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEK 289
EE + + EEE+RKRK++E QK L+++ ++
Sbjct: 864 EEAARLRHEEEERKRKELE----------------------------VQRQKELMRQRQQ 895
Query: 290 GDE--KELDKREKAKKLDKENLSDERASG-QSCTLPKRSDSELKDEKPKRPEDESGRDYR 346
E + L ++++ ++L + L G QS T +S + L + ++ E+E R R
Sbjct: 896 QQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLR 955
Query: 347 EREREYERDQERILRERERLKRQE 370
E +R +R+ + L+++++ ++Q+
Sbjct: 956 EEQRRQQRELMKALQQQQQQQQQK 979
Score = 30.8 bits (68), Expect = 2.9
Identities = 37/187 (19%), Positives = 71/187 (37%), Gaps = 34/187 (18%)
Query: 155 DDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEK 214
DD+ YR+ + ++ S PE LE+ E E+ ++ LK Q+ +
Sbjct: 257 DDERGYRRVRSGSGSIDDDRDSLPEWCLEDAE---EEMGTFDSSGAFLSLKKVQKEPIPE 313
Query: 215 REERRRREIERKRQREE----ERRKWKEEEKRKRKDIEKLKKI-----DRIPERD----- 260
+E R ++ + + + KE +K +K+ EK ++ + P+
Sbjct: 314 EQEMDFRPVDEGEECSDSEGSHNEEAKEPDKTNKKEGEKTDRVGVEASEETPQTSSSSAR 373
Query: 261 ---------------KLKDEPKIKVHRFLLQAVNQKNLL--KKPEKGDEKELDKREKAKK 303
+ KDEPK + + +N L K P +GDE D ++ +
Sbjct: 374 PGTPSDHQSQEASQFERKDEPKTEQTEKAEEETRMENSLPAKVPSRGDEMVADVQQPLSQ 433
Query: 304 LDKENLS 310
+ + S
Sbjct: 434 IPSDTAS 440
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sapiens]
Length = 1320
Score = 82.0 bits (201), Expect = 1e-15
Identities = 70/311 (22%), Positives = 144/311 (46%), Gaps = 49/311 (15%)
Query: 175 TSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERR 234
T+TP LE+++ + AK L + + MR ++ EE R+R+ E +RQ+EE R
Sbjct: 737 TTTPGPALEQLQQLEKAKAAK-----LEQERREAEMRAKREEEERKRQEELRRQQEEILR 791
Query: 235 KWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKE 294
+ +EEE+++R++ E ++ K E ++ R ++ + + ++ +E+
Sbjct: 792 RQQEEERKRREEEELARR----------KQEEALRRQR-------EQEIALRRQREEEER 834
Query: 295 LDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYER 354
+ E ++L++ +E Q L K+ E + K R E+E+ R E E
Sbjct: 835 QQQEEALRRLEERRREEEERRKQEELLRKQ---EEEAAKWAREEEEAQRRLEENRLRMEE 891
Query: 355 DQERILRERERLKRQEEERRRQKE----RYEKEKTFKRKEEEMKKEK------------- 397
+ R+ E E KR+E E +RQKE R ++++ +R +++ ++++
Sbjct: 892 EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 951
Query: 398 DTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNR------ 451
++++T S+ +K E++ E R+ R + R M+ Q + + +
Sbjct: 952 QQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWG 1011
Query: 452 -LCPPDDSTKS 461
+ P +TKS
Sbjct: 1012 NVSKPSGTTKS 1022
Score = 49.7 bits (117), Expect = 6e-06
Identities = 46/204 (22%), Positives = 94/204 (46%), Gaps = 33/204 (16%)
Query: 172 EKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQR-E 230
E+ E L +E + RE ++ L + ++ + + EE +R +E R R E
Sbjct: 831 EEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRME 890
Query: 231 EERRKWK-EEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEK 289
EE + + EEE+RKRK++E QK L+++ ++
Sbjct: 891 EEAARLRHEEEERKRKELE----------------------------VQRQKELMRQRQQ 922
Query: 290 GDE--KELDKREKAKKLDKENLSDERASG-QSCTLPKRSDSELKDEKPKRPEDESGRDYR 346
E + L ++++ ++L + L G QS T +S + L + ++ E+E R R
Sbjct: 923 QQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLR 982
Query: 347 EREREYERDQERILRERERLKRQE 370
E +R +R+ + L+++++ ++Q+
Sbjct: 983 EEQRRQQRELMKALQQQQQQQQQK 1006
Score = 31.2 bits (69), Expect = 2.2
Identities = 32/150 (21%), Positives = 62/150 (41%), Gaps = 4/150 (2%)
Query: 155 DDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEK 214
DD+ YR+ + ++ S PE LE+ E E+ ++ LK Q+ +
Sbjct: 285 DDERGYRRVRSGSGSIDDDRDSLPEWCLEDAE---EEMGTFDSSGAFLSLKKVQKEPIPE 341
Query: 215 REERRRREIERKRQREEERRKWKEEEKRKRKDIEKL-KKIDRIPERDKLKDEPKIKVHRF 273
+E R ++ + + EE K K +K +K DR+ + + R
Sbjct: 342 EQEMDFRPVDEGEECSDSEGSHNEEAKEPDKTNKKEGEKTDRVGVASEETPQTSSSSARP 401
Query: 274 LLQAVNQKNLLKKPEKGDEKELDKREKAKK 303
+ +Q + E+ DE + ++ EKA++
Sbjct: 402 GTPSDHQSQEASQFERKDEPKTEQTEKAEE 431
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sapiens]
Length = 1299
Score = 82.0 bits (201), Expect = 1e-15
Identities = 70/311 (22%), Positives = 144/311 (46%), Gaps = 49/311 (15%)
Query: 175 TSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERR 234
T+TP LE+++ + AK L + + MR ++ EE R+R+ E +RQ+EE R
Sbjct: 716 TTTPGPALEQLQQLEKAKAAK-----LEQERREAEMRAKREEEERKRQEELRRQQEEILR 770
Query: 235 KWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKE 294
+ +EEE+++R++ E ++ K E ++ R ++ + + ++ +E+
Sbjct: 771 RQQEEERKRREEEELARR----------KQEEALRRQR-------EQEIALRRQREEEER 813
Query: 295 LDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYER 354
+ E ++L++ +E Q L K+ E + K R E+E+ R E E
Sbjct: 814 QQQEEALRRLEERRREEEERRKQEELLRKQ---EEEAAKWAREEEEAQRRLEENRLRMEE 870
Query: 355 DQERILRERERLKRQEEERRRQKE----RYEKEKTFKRKEEEMKKEK------------- 397
+ R+ E E KR+E E +RQKE R ++++ +R +++ ++++
Sbjct: 871 EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 930
Query: 398 DTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNR------ 451
++++T S+ +K E++ E R+ R + R M+ Q + + +
Sbjct: 931 QQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWG 990
Query: 452 -LCPPDDSTKS 461
+ P +TKS
Sbjct: 991 NVSKPSGTTKS 1001
Score = 49.7 bits (117), Expect = 6e-06
Identities = 46/204 (22%), Positives = 94/204 (46%), Gaps = 33/204 (16%)
Query: 172 EKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQR-E 230
E+ E L +E + RE ++ L + ++ + + EE +R +E R R E
Sbjct: 810 EEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRME 869
Query: 231 EERRKWK-EEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEK 289
EE + + EEE+RKRK++E QK L+++ ++
Sbjct: 870 EEAARLRHEEEERKRKELE----------------------------VQRQKELMRQRQQ 901
Query: 290 GDE--KELDKREKAKKLDKENLSDERASG-QSCTLPKRSDSELKDEKPKRPEDESGRDYR 346
E + L ++++ ++L + L G QS T +S + L + ++ E+E R R
Sbjct: 902 QQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLR 961
Query: 347 EREREYERDQERILRERERLKRQE 370
E +R +R+ + L+++++ ++Q+
Sbjct: 962 EEQRRQQRELMKALQQQQQQQQQK 985
Score = 30.8 bits (68), Expect = 2.9
Identities = 37/187 (19%), Positives = 71/187 (37%), Gaps = 34/187 (18%)
Query: 155 DDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEK 214
DD+ YR+ + ++ S PE LE+ E E+ ++ LK Q+ +
Sbjct: 263 DDERGYRRVRSGSGSIDDDRDSLPEWCLEDAE---EEMGTFDSSGAFLSLKKVQKEPIPE 319
Query: 215 REERRRREIERKRQREE----ERRKWKEEEKRKRKDIEKLKKI-----DRIPERD----- 260
+E R ++ + + + KE +K +K+ EK ++ + P+
Sbjct: 320 EQEMDFRPVDEGEECSDSEGSHNEEAKEPDKTNKKEGEKTDRVGVEASEETPQTSSSSAR 379
Query: 261 ---------------KLKDEPKIKVHRFLLQAVNQKNLL--KKPEKGDEKELDKREKAKK 303
+ KDEPK + + +N L K P +GDE D ++ +
Sbjct: 380 PGTPSDHQSQEASQFERKDEPKTEQTEKAEEETRMENSLPAKVPSRGDEMVADVQQPLSQ 439
Query: 304 LDKENLS 310
+ + S
Sbjct: 440 IPSDTAS 446
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapiens]
Length = 1299
Score = 82.0 bits (201), Expect = 1e-15
Identities = 70/311 (22%), Positives = 144/311 (46%), Gaps = 49/311 (15%)
Query: 175 TSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERR 234
T+TP LE+++ + AK L + + MR ++ EE R+R+ E +RQ+EE R
Sbjct: 716 TTTPGPALEQLQQLEKAKAAK-----LEQERREAEMRAKREEEERKRQEELRRQQEEILR 770
Query: 235 KWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKE 294
+ +EEE+++R++ E ++ K E ++ R ++ + + ++ +E+
Sbjct: 771 RQQEEERKRREEEELARR----------KQEEALRRQR-------EQEIALRRQREEEER 813
Query: 295 LDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYER 354
+ E ++L++ +E Q L K+ E + K R E+E+ R E E
Sbjct: 814 QQQEEALRRLEERRREEEERRKQEELLRKQ---EEEAAKWAREEEEAQRRLEENRLRMEE 870
Query: 355 DQERILRERERLKRQEEERRRQKE----RYEKEKTFKRKEEEMKKEK------------- 397
+ R+ E E KR+E E +RQKE R ++++ +R +++ ++++
Sbjct: 871 EAARLRHEEEERKRKELEVQRQKELMRQRQQQQEALRRLQQQQQQQQLAQMKLPSSSTWG 930
Query: 398 DTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNR------ 451
++++T S+ +K E++ E R+ R + R M+ Q + + +
Sbjct: 931 QQSNTTACQSQATLSLAEIQKLEEERERQLREEQRRQQRELMKALQQQQQQQQQKLSGWG 990
Query: 452 -LCPPDDSTKS 461
+ P +TKS
Sbjct: 991 NVSKPSGTTKS 1001
Score = 49.7 bits (117), Expect = 6e-06
Identities = 46/204 (22%), Positives = 94/204 (46%), Gaps = 33/204 (16%)
Query: 172 EKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQR-E 230
E+ E L +E + RE ++ L + ++ + + EE +R +E R R E
Sbjct: 810 EEERQQQEEALRRLEERRREEEERRKQEELLRKQEEEAAKWAREEEEAQRRLEENRLRME 869
Query: 231 EERRKWK-EEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEK 289
EE + + EEE+RKRK++E QK L+++ ++
Sbjct: 870 EEAARLRHEEEERKRKELE----------------------------VQRQKELMRQRQQ 901
Query: 290 GDE--KELDKREKAKKLDKENLSDERASG-QSCTLPKRSDSELKDEKPKRPEDESGRDYR 346
E + L ++++ ++L + L G QS T +S + L + ++ E+E R R
Sbjct: 902 QQEALRRLQQQQQQQQLAQMKLPSSSTWGQQSNTTACQSQATLSLAEIQKLEEERERQLR 961
Query: 347 EREREYERDQERILRERERLKRQE 370
E +R +R+ + L+++++ ++Q+
Sbjct: 962 EEQRRQQRELMKALQQQQQQQQQK 985
Score = 30.8 bits (68), Expect = 2.9
Identities = 37/187 (19%), Positives = 71/187 (37%), Gaps = 34/187 (18%)
Query: 155 DDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEK 214
DD+ YR+ + ++ S PE LE+ E E+ ++ LK Q+ +
Sbjct: 263 DDERGYRRVRSGSGSIDDDRDSLPEWCLEDAE---EEMGTFDSSGAFLSLKKVQKEPIPE 319
Query: 215 REERRRREIERKRQREE----ERRKWKEEEKRKRKDIEKLKKI-----DRIPERD----- 260
+E R ++ + + + KE +K +K+ EK ++ + P+
Sbjct: 320 EQEMDFRPVDEGEECSDSEGSHNEEAKEPDKTNKKEGEKTDRVGVEASEETPQTSSSSAR 379
Query: 261 ---------------KLKDEPKIKVHRFLLQAVNQKNLL--KKPEKGDEKELDKREKAKK 303
+ KDEPK + + +N L K P +GDE D ++ +
Sbjct: 380 PGTPSDHQSQEASQFERKDEPKTEQTEKAEEETRMENSLPAKVPSRGDEMVADVQQPLSQ 439
Query: 304 LDKENLS 310
+ + S
Sbjct: 440 IPSDTAS 446
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 81.3 bits (199), Expect = 2e-15
Identities = 79/335 (23%), Positives = 150/335 (44%), Gaps = 36/335 (10%)
Query: 137 QKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLLEEIEAKNRELIAKK 196
Q + + K T ++ D E FLE A E+ + L+E + +E
Sbjct: 71 QNSVPDEEAKTTTTNTQVEGDDE-AAFLERLARREERR----QKRLQEALERQKEFDPTI 125
Query: 197 TTPLLSF---------LKNKQRMREEKREERRRR-EIERKRQ--REEERRKWKEEEKRKR 244
T LS +N+ +EEK E R+ R EIE + ++ W++ E+ K+
Sbjct: 126 TDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKK 185
Query: 245 KDIEKLKKIDRIPERDKL-KDEPKIKVHRFLLQAVNQKNLL---------KKPEKGDEKE 294
+D EK ++ + P+R + +++ ++ V ++ + ++ ++P++ +E+E
Sbjct: 186 EDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEERE 245
Query: 295 LDKREKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYER 354
E + E ERA + L +K E+ K+ DE R E + +
Sbjct: 246 QGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQE 305
Query: 355 DQERILRERERLKRQE----EERRRQKER----YEKEKTFKRKEEEMKKEKDTLRDKGKK 406
+ R ERER++ +E EER+R KE E+ + K +E+ +E+ ++++ K+
Sbjct: 306 RERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKR 365
Query: 407 AESTESIGSSEKTEK-KEEVVKRDRIRNKDRPAMQ 440
A +E+ EK K E KR++ + + AMQ
Sbjct: 366 AAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQ 400
Score = 65.1 bits (157), Expect = 1e-10
Identities = 60/272 (22%), Positives = 125/272 (45%), Gaps = 24/272 (8%)
Query: 184 EIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRK 243
E+ + + +++ T ++S LKN Q EE ++E R + + E+ EEE ++
Sbjct: 209 EVMVEEKTTESQEETVVMS-LKNGQISSEEPKQEEEREQGSDEISHHEKM----EEEDKE 263
Query: 244 RKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKK 303
R + E+ + ER K + + KI R ++A + ++ + E+ RE+ K+
Sbjct: 264 RAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMREEEKR 323
Query: 304 LDKENL---SDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERIL 360
+E +E+ + + K + +E+ + E+E R ER+R ++E+
Sbjct: 324 AAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEK-RAAEERQRARAEEEEKAK 382
Query: 361 RERERLKRQEEERRR--QKERYEKEKTFKRKE----EEMKKEKDTLR---------DKGK 405
E ++ +Q EE++ Q+ + + EK ++ E E K ++D L+ +KG
Sbjct: 383 VEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGT 442
Query: 406 KAESTESIGSSEKTEKKEEVVKRDRIRNKDRP 437
K ++ +K K+E +K ++I+ P
Sbjct: 443 KVQAKREKLQEDKPTFKKEEIKDEKIKKDKEP 474
Score = 61.2 bits (147), Expect = 2e-09
Identities = 68/275 (24%), Positives = 121/275 (44%), Gaps = 51/275 (18%)
Query: 205 KNKQRMREEKR---EERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDK 261
+ +QR++EE++ EER+R + E KR EE +R EEE++ + +E+ K+ ++ E+
Sbjct: 340 EERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAK--VEEQKRNKQLEEKKH 397
Query: 262 LKDEPKIKVHRFLLQA----VNQKN----------LLKKPEKGDEKELDKREKAKK---- 303
E KIK + + VN+K L K+ E+ K KREK ++
Sbjct: 398 AMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPT 457
Query: 304 LDKENLSDERASG---------------QSCTLPKRSDSELKDEKPKRPEDESGR----- 343
KE + DE+ + T K + E K K E+ R
Sbjct: 458 FKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRA 517
Query: 344 --DYRERER----EYERDQERILRERERLKRQEEERRRQKERYE--KEKTFKRKEEEMKK 395
D +E E E + E + R R + +E E+ +QK++ + + K+K EE +K
Sbjct: 518 SVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRK 577
Query: 396 EKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDR 430
+ + K+ E+ + E+ + +E ++R R
Sbjct: 578 VLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRR 612
Score = 60.5 bits (145), Expect = 3e-09
Identities = 54/245 (22%), Positives = 117/245 (47%), Gaps = 32/245 (13%)
Query: 205 KNKQRMREEKRE--ERRRREIERKRQREEERRKWKEEEKRKRKDIEKLKKIDRIPERDKL 262
+ ++RMREE++ E R+R E +++ EER++ KEEEKR + ER ++
Sbjct: 312 EERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAE------------ERQRI 359
Query: 263 KDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKA---KKLDKENLSDERASGQSC 319
K+E K ++ K E+ K+L++++ A K+ E + +++ G+
Sbjct: 360 KEEEKRAAEERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKV-EQKIEGKWV 418
Query: 320 TLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRER---ERLKRQEEERRRQ 376
K + +L+ K+ +E G + + + + D+ +E E++K+ +E +
Sbjct: 419 NEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEV 478
Query: 377 KERYEKEKTFKRKEEE--------MKKEKDTLRDKGKKA--ESTESIGSSE-KTEKKEEV 425
K +++K F + + +K ++T G +A ++ E+ G+ + + K+ E
Sbjct: 479 KSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEE 538
Query: 426 VKRDR 430
++R R
Sbjct: 539 LRRRR 543
Score = 57.4 bits (137), Expect = 3e-08
Identities = 58/312 (18%), Positives = 132/312 (42%), Gaps = 24/312 (7%)
Query: 188 KNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQREEERRKWKEEEKRKRKDI 247
+ REL +K + + R + EE RE R+ ++E R+K +EE + D
Sbjct: 6 RRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQ 65
Query: 248 EKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDKREKAKKLDKE 307
++ + +P+ +E K ++ ++ L++ + +E+ + ++A L+++
Sbjct: 66 VEVNAQNSVPD-----EEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEA--LERQ 118
Query: 308 NLSDERASGQSCTLPKR------SDSELKDEKPKRPEDESGRDYREREREYERDQERILR 361
D + S +LP R +++E +++ K + + E E + Q+ R
Sbjct: 119 KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
Query: 362 ERERLKRQEEERRRQKERYEK---------EKTFKRKEEEMKKEKDTLRDKGKKAESTES 412
+ E K++++E+ ++E K E + K E ++E + K + S E
Sbjct: 179 DAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEP 238
Query: 413 IGSSEKTEKKEEVVKRDRI--RNKDRPAMQLYQPGARSRNRLCPPDDSTKSGDSAAERKQ 470
E+ + +E+ +++ +K+R + + A R R+ D + + A +
Sbjct: 239 KQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAE 298
Query: 471 ESGISHRKEGGE 482
E + +E E
Sbjct: 299 EKAAAQERERRE 310
Score = 56.2 bits (134), Expect = 6e-08
Identities = 69/324 (21%), Positives = 129/324 (39%), Gaps = 70/324 (21%)
Query: 168 ATDNEKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKR----EERRRREI 223
A + E+M + EE + E K+ +K +++ E+R EE +R
Sbjct: 311 AEERERMREEEKRAAEERQRIKEE--EKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAE 368
Query: 224 ERKRQREEERRKWKEEEKRKRKDIEKLKKI---------------------DRIPERDKL 262
ER+R R EE K K EE+++ K +E+ K ++ + DKL
Sbjct: 369 ERQRARAEEEEKAKVEEQKRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKL 428
Query: 263 K--------DEPKIKVHRFLLQAVNQKNLLKKPEKGDEK---ELDKREKAK--------- 302
+ +E KV + K KK E DEK + + +E+ K
Sbjct: 429 QTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGF 488
Query: 303 -------------KLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYRERE 349
KL + R G++ K ++ + E KR E+ R
Sbjct: 489 TEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETES 548
Query: 350 REYER---DQERILRERERLKRQEEERRR-------QKERYEKEKTFKRKEEEMKKEKDT 399
E+E+ Q+ E E LK++ EERR+ ++++ E ++ + +EE+ + +++
Sbjct: 549 EEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEI 608
Query: 400 LRDKGKKAESTESIGSSEKTEKKE 423
R + + AE + + ++ K+
Sbjct: 609 ERRRAEAAEKRQKMPEDGLSDDKK 632
Score = 52.4 bits (124), Expect = 9e-07
Identities = 76/386 (19%), Positives = 156/386 (40%), Gaps = 86/386 (22%)
Query: 122 NKGQEYPAIVEFAPFQKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETL 181
N E A E + + + K+ + +G + D E ++ D E T+T T
Sbjct: 30 NDDDEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNA--QNSVPDEEAKTTTTNTQ 87
Query: 182 LE-EIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIERKRQ------------ 228
+E + EA E +A+ REE+R++R + +ER+++
Sbjct: 88 VEGDDEAAFLERLAR---------------REERRQKRLQEALERQKEFDPTITDASLSL 132
Query: 229 -----------REEERRKWKEEEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQA 277
E ++ K E +++R +IE+ + + + +++ +D +
Sbjct: 133 PSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEE---------- 182
Query: 278 VNQKNLLKKPEKGDEKELDKREKAKKLDKENLSDERA--SGQSCTLPKRSDSELKDEKPK 335
N+K +K E+ +EK KR + E + +E+ S + + + ++ E+PK
Sbjct: 183 -NKKEDKEKEEEEEEKP--KRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPK 239
Query: 336 RPED-ESGRD-YREREREYERDQERILRERERLKRQEEERRRQKERYEKEKTFKRKEEEM 393
+ E+ E G D E+ E D+ER ER RL+ +E ER K E+
Sbjct: 240 QEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERI--------------KAEQD 285
Query: 394 KKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLC 453
KK + D+ + E+ E+K +R+R ++R M+ + A +
Sbjct: 286 KK----IADERARIEA----------EEKAAAQERERREAEERERMREEEKRAAEERQRI 331
Query: 454 PPDDSTKSGDSAAERKQESGISHRKE 479
++ + + +++E + ++
Sbjct: 332 KEEEKRAAEERQRIKEEEKRAAEERQ 357
Score = 50.4 bits (119), Expect = 3e-06
Identities = 57/233 (24%), Positives = 105/233 (45%), Gaps = 28/233 (12%)
Query: 213 EKREERRRREIERKRQR-EEERRKWKEEE---KRKRKDIEKLKKIDRIPERDKLKDEPKI 268
+K+ E + +++ KR++ +E++ +K+EE ++ +KD E +++ +R K E K
Sbjct: 434 KKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTEVKS 493
Query: 269 KVHRFLLQAVNQ-KNLLKKPEKGDEKELDKREKAKKLDK----ENLSDERASGQSCTLPK 323
+ F+ + +N +P + + E A +++ E L R +S K
Sbjct: 494 QNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEEFEK 553
Query: 324 RSDS------ELKDEKPKRPEDESGRDYREREREYERDQERILRERERLKR--QEEERRR 375
EL++ K KR E + E+ R+ E + +R LRE E +R +E ERRR
Sbjct: 554 LKQKQQEAALELEELKKKREERRKVLEEEEQRRKQE-EADRKLREEEEKRRLKEEIERRR 612
Query: 376 QKERYEKEKTFKRKEEEMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKR 428
+ E+ K +D L D K + GSS K E++ E + +
Sbjct: 613 A----------EAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEFLNK 655
Score = 33.9 bits (76), Expect = 0.34
Identities = 23/81 (28%), Positives = 44/81 (54%), Gaps = 5/81 (6%)
Query: 165 ESYATDNEKMTSTPETLLEEIEAKNRELIAKKTTPLLSFLKNKQRMREEKREERRRREIE 224
E+ + + EK+ + E+E EL K+ + +QR ++E+ + + R E E
Sbjct: 545 ETESEEFEKLKQKQQEAALELE----ELKKKREERRKVLEEEEQRRKQEEADRKLREEEE 600
Query: 225 RKRQREE-ERRKWKEEEKRKR 244
++R +EE ERR+ + EKR++
Sbjct: 601 KRRLKEEIERRRAEAAEKRQK 621
Score = 30.8 bits (68), Expect = 2.9
Identities = 23/105 (21%), Positives = 45/105 (42%), Gaps = 17/105 (16%)
Query: 347 EREREYERDQERILR-ERERLKRQ-----EEERRRQKERYEKEKTFKRKEE--------- 391
ER RE R + +R E ER+ Q EEE R++ R +++ ++K+E
Sbjct: 5 ERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQVTD 64
Query: 392 --EMKKEKDTLRDKGKKAESTESIGSSEKTEKKEEVVKRDRIRNK 434
E+ + ++ K + + ++ E + +R+ R K
Sbjct: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQK 109
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.128 0.347
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,482,542
Number of Sequences: 37866
Number of extensions: 1121746
Number of successful extensions: 47883
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 867
Number of HSP's successfully gapped in prelim test: 1343
Number of HSP's that attempted gapping in prelim test: 9286
Number of HSP's gapped (non-prelim): 12711
length of query: 483
length of database: 18,247,518
effective HSP length: 106
effective length of query: 377
effective length of database: 14,233,722
effective search space: 5366113194
effective search space used: 5366113194
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.