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Search of human proteins with 18375525
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18375525 UPF3 regulator of nonsense transcripts homolog A
isoform hUpf3pdelta [Homo sapiens]
(443 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|18375525 UPF3 regulator of nonsense transcripts homolog A iso... 895 0.0
gi|12711676 UPF3 regulator of nonsense transcripts homolog A iso... 879 0.0
gi|12711674 UPF3 regulator of nonsense transcripts homolog B iso... 332 4e-91
gi|18375528 UPF3 regulator of nonsense transcripts homolog B iso... 323 3e-88
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 77 2e-14
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 77 2e-14
gi|148746195 trichohyalin [Homo sapiens] 74 2e-13
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 73 6e-13
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 73 6e-13
gi|29568103 U1 small nuclear ribonucleoprotein 70 kDa [Homo sapi... 72 8e-13
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 70 3e-12
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 68 2e-11
gi|239747174 PREDICTED: hypothetical protein XP_002343931, parti... 67 4e-11
gi|4503509 eukaryotic translation initiation factor 3, subunit 1... 65 9e-11
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 65 1e-10
gi|169167715 PREDICTED: hypothetical protein [Homo sapiens] 64 2e-10
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ... 64 2e-10
gi|239757964 PREDICTED: hypothetical protein [Homo sapiens] 64 3e-10
gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo sap... 63 6e-10
gi|239747891 PREDICTED: hypothetical protein [Homo sapiens] 62 8e-10
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 62 8e-10
gi|115298682 HBxAg transactivated protein 2 [Homo sapiens] 62 8e-10
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 61 2e-09
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 60 3e-09
gi|169218106 PREDICTED: hypothetical protein, partial [Homo sapi... 60 4e-09
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 60 4e-09
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 60 4e-09
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 60 5e-09
gi|239745153 PREDICTED: similar to Putative golgin subfamily A m... 60 5e-09
gi|239745127 PREDICTED: similar to Putative golgin subfamily A m... 60 5e-09
>gi|18375525 UPF3 regulator of nonsense transcripts homolog A
isoform hUpf3pdelta [Homo sapiens]
Length = 443
Score = 895 bits (2314), Expect = 0.0
Identities = 443/443 (100%), Positives = 443/443 (100%)
Query: 1 MRSEKEGAGGLRAAVAARGPSGREKLSALEVQFHRDSQQQEAETPPTSSSGCGGGAGKPR 60
MRSEKEGAGGLRAAVAARGPSGREKLSALEVQFHRDSQQQEAETPPTSSSGCGGGAGKPR
Sbjct: 1 MRSEKEGAGGLRAAVAARGPSGREKLSALEVQFHRDSQQQEAETPPTSSSGCGGGAGKPR 60
Query: 61 EEKRTALSKVVIRRLPPGLTKEQLEEQLRPLPAHDYFEFFAADLSLYPHLYSRAYINFRN 120
EEKRTALSKVVIRRLPPGLTKEQLEEQLRPLPAHDYFEFFAADLSLYPHLYSRAYINFRN
Sbjct: 61 EEKRTALSKVVIRRLPPGLTKEQLEEQLRPLPAHDYFEFFAADLSLYPHLYSRAYINFRN 120
Query: 121 PDDILLFRDRFDGYIFLDSKDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARR 180
PDDILLFRDRFDGYIFLDSKDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARR
Sbjct: 121 PDDILLFRDRFDGYIFLDSKDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARR 180
Query: 181 TTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKK 240
TTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKK
Sbjct: 181 TTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKK 240
Query: 241 IAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEP 300
IAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEP
Sbjct: 241 IAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEP 300
Query: 301 QETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPG 360
QETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPG
Sbjct: 301 QETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPG 360
Query: 361 QDRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPALQLYDPGARFRAREC 420
QDRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPALQLYDPGARFRAREC
Sbjct: 361 QDRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPALQLYDPGARFRAREC 420
Query: 421 GGNRRICKAEGSGTGPEKREEAE 443
GGNRRICKAEGSGTGPEKREEAE
Sbjct: 421 GGNRRICKAEGSGTGPEKREEAE 443
>gi|12711676 UPF3 regulator of nonsense transcripts homolog A
isoform hUpf3p [Homo sapiens]
Length = 476
Score = 879 bits (2270), Expect = 0.0
Identities = 443/476 (93%), Positives = 443/476 (93%), Gaps = 33/476 (6%)
Query: 1 MRSEKEGAGGLRAAVAARGPSGREKLSALEVQFHRDSQQQEAETPPTSSSGCGGGAGKPR 60
MRSEKEGAGGLRAAVAARGPSGREKLSALEVQFHRDSQQQEAETPPTSSSGCGGGAGKPR
Sbjct: 1 MRSEKEGAGGLRAAVAARGPSGREKLSALEVQFHRDSQQQEAETPPTSSSGCGGGAGKPR 60
Query: 61 EEKRTALSKVVIRRLPPGLTKEQLEEQLRPLPAHDYFEFFAADLSLYPHLYSRAYINFRN 120
EEKRTALSKVVIRRLPPGLTKEQLEEQLRPLPAHDYFEFFAADLSLYPHLYSRAYINFRN
Sbjct: 61 EEKRTALSKVVIRRLPPGLTKEQLEEQLRPLPAHDYFEFFAADLSLYPHLYSRAYINFRN 120
Query: 121 PDDILLFRDRFDGYIFLDSK---------------------------------DPEYKKF 147
PDDILLFRDRFDGYIFLDSK DPEYKKF
Sbjct: 121 PDDILLFRDRFDGYIFLDSKGLEYPAVVEFAPFQKIAKKKLRKKDAKTGSIEDDPEYKKF 180
Query: 148 LETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERR 207
LETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERR
Sbjct: 181 LETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERR 240
Query: 208 RRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKE 267
RRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKE
Sbjct: 241 RRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKE 300
Query: 268 RGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQR 327
RGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQR
Sbjct: 301 RGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQR 360
Query: 328 YHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRC 387
YHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRC
Sbjct: 361 YHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRC 420
Query: 388 DDSPAPRKERLANKDRPALQLYDPGARFRARECGGNRRICKAEGSGTGPEKREEAE 443
DDSPAPRKERLANKDRPALQLYDPGARFRARECGGNRRICKAEGSGTGPEKREEAE
Sbjct: 421 DDSPAPRKERLANKDRPALQLYDPGARFRARECGGNRRICKAEGSGTGPEKREEAE 476
>gi|12711674 UPF3 regulator of nonsense transcripts homolog B
isoform 2 [Homo sapiens]
Length = 470
Score = 332 bits (851), Expect = 4e-91
Identities = 191/451 (42%), Positives = 274/451 (60%), Gaps = 73/451 (16%)
Query: 30 EVQFHRDSQQQEAETPPTSSSGCGGGA------GKPRE----EKRTALSKVVIRRLPPGL 79
E + HR +++ P ++G GGG G+ ++ EK+ ALSKVVIRRLPP L
Sbjct: 3 EEKEHRPKEKRVTLLTPAGATGSGGGTSGDSSKGEDKQDRNKEKKEALSKVVIRRLPPTL 62
Query: 80 TKEQLEEQLRPLPAHDYFEFFAADLSLYPHLYSRAYINFRNPDDILLFRDRFDGYIFLDS 139
TKEQL+E L+P+P HDYFEFF+ D SLYPH+Y+RAYINF+N +DI+LFRDRFDGY+FLD+
Sbjct: 63 TKEQLQEHLQPMPEHDYFEFFSNDTSLYPHMYARAYINFKNQEDIILFRDRFDGYVFLDN 122
Query: 140 K---------------------------------DPEYKKFLETYCVEEEKTSANPETLL 166
K DPEY+KFLE+Y + EK ++ PETLL
Sbjct: 123 KGQEYPAIVEFAPFQKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLL 182
Query: 167 GEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRRE 226
E+EAK RELIA++TTPLL ++KN KQR+REEKREERRRRE+E+KR REEE+R+ +E
Sbjct: 183 EEIEAKNRELIAKKTTPLLSFLKN----KQRMREEKREERRRREIERKRQREEERRKWKE 238
Query: 227 EERCKKKETDKQKKI--------AEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGK 278
EE+ K+K+ +K KKI + E +IKLLKKPEKG+E +K +E+ +++D
Sbjct: 239 EEKRKRKDIEKLKKIDRIPERDKLKDEPKIKLLKKPEKGDEKELDK-REKAKKLDKENLS 297
Query: 279 QESCAPGAVVKARPMEGSLEE-----PQETSHSGSDKEHRDVERSQE---QESEAQRYHV 330
E + + + + L++ P++ S + R+ ER QE +E E +
Sbjct: 298 DERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQERILRERERLKRQE 357
Query: 331 DDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRCD-D 389
++ RR + +E E+ +R E+E + K +D+GKK E+ E +G +++ +
Sbjct: 358 EERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKK--------AESTESIGSSEKTEKK 409
Query: 390 SPAPRKERLANKDRPALQLYDPGARFRAREC 420
+++R+ NKDRPA+QLY PGAR R R C
Sbjct: 410 EEVVKRDRIRNKDRPAMQLYQPGARSRNRLC 440
>gi|18375528 UPF3 regulator of nonsense transcripts homolog B
isoform 1 [Homo sapiens]
Length = 483
Score = 323 bits (827), Expect = 3e-88
Identities = 191/464 (41%), Positives = 274/464 (59%), Gaps = 86/464 (18%)
Query: 30 EVQFHRDSQQQEAETPPTSSSGCGGGA------GKPRE----EKRTALSKVVIRRLPPGL 79
E + HR +++ P ++G GGG G+ ++ EK+ ALSKVVIRRLPP L
Sbjct: 3 EEKEHRPKEKRVTLLTPAGATGSGGGTSGDSSKGEDKQDRNKEKKEALSKVVIRRLPPTL 62
Query: 80 TKEQLEEQLRPLPAHDYFEFFAADLSLYPHLYSRAYINFRNPDDILLFRDRFDGYIFLDS 139
TKEQL+E L+P+P HDYFEFF+ D SLYPH+Y+RAYINF+N +DI+LFRDRFDGY+FLD+
Sbjct: 63 TKEQLQEHLQPMPEHDYFEFFSNDTSLYPHMYARAYINFKNQEDIILFRDRFDGYVFLDN 122
Query: 140 K---------------------------------DPEYKKFLETYCVEEEKTSANPETLL 166
K DPEY+KFLE+Y + EK ++ PETLL
Sbjct: 123 KGQEYPAIVEFAPFQKAAKKKTKKRDTKVGTIDDDPEYRKFLESYATDNEKMTSTPETLL 182
Query: 167 GEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRRE 226
E+EAK RELIA++TTPLL ++KN KQR+REEKREERRRRE+E+KR REEE+R+ +E
Sbjct: 183 EEIEAKNRELIAKKTTPLLSFLKN----KQRMREEKREERRRREIERKRQREEERRKWKE 238
Query: 227 EERCKKKETDKQKKI--------AEKEVRIK-------------LLKKPEKGEEPTTEKP 265
EE+ K+K+ +K KKI + E +IK LLKKPEKG+E +K
Sbjct: 239 EEKRKRKDIEKLKKIDRIPERDKLKDEPKIKVHRFLLQAVNQKNLLKKPEKGDEKELDK- 297
Query: 266 KERGEEIDTGGGKQESCAPGAVVKARPMEGSLEE-----PQETSHSGSDKEHRDVERSQE 320
+E+ +++D E + + + + L++ P++ S + R+ ER QE
Sbjct: 298 REKAKKLDKENLSDERASGQSCTLPKRSDSELKDEKPKRPEDESGRDYREREREYERDQE 357
Query: 321 ---QESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEA 377
+E E + ++ RR + +E E+ +R E+E + K +D+GKK E+
Sbjct: 358 RILRERERLKRQEEERRRQKERYEKEKTFKRKEEEMKKEKDTLRDKGKK--------AES 409
Query: 378 MERLGRAQRCD-DSPAPRKERLANKDRPALQLYDPGARFRAREC 420
E +G +++ + +++R+ NKDRPA+QLY PGAR R R C
Sbjct: 410 TESIGSSEKTEKKEEVVKRDRIRNKDRPAMQLYQPGARSRNRLC 453
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
Length = 624
Score = 77.4 bits (189), Expect = 2e-14
Identities = 63/253 (24%), Positives = 111/253 (43%), Gaps = 15/253 (5%)
Query: 189 KNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRI 248
K+R R R +++ RR + KKR + E+R+ R + K D ++KI EKE
Sbjct: 332 KHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVK 391
Query: 249 KLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGS 308
+ ++ E+ E EK KERG+ D +++ + + E E +E H
Sbjct: 392 EKDREKEREREKEREKEKERGKNKDRDKEREKD-------REKDKEKDREREREKEHEKD 444
Query: 309 DKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGS 368
+ ++ E+ +E+E E R D +R + + R RS + R + ++R ++ S
Sbjct: 445 RDKEKEKEQDKEKEREKDRSKEIDEKRKK--DKKSRTPPRSYNASRRSRSSSRERRRRRS 502
Query: 369 QDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPALQLYDPGARFRARECGGNRRICK 428
+ S + + R + SP+PR KD+ + D + R RE + R K
Sbjct: 503 RSSSRSPRTSKTIKR--KSSRSPSPRSRN--KKDKKREKERDHISERRERERSTSMR--K 556
Query: 429 AEGSGTGPEKREE 441
+ G EK E+
Sbjct: 557 SSNDRDGKEKLEK 569
Score = 69.3 bits (168), Expect = 7e-12
Identities = 61/222 (27%), Positives = 101/222 (45%), Gaps = 14/222 (6%)
Query: 186 EYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKE 245
E IK ++ K++ RE++RE + RE EK+R + +++ + RE++R K KE D++++ EKE
Sbjct: 382 EKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERE-REKE 440
Query: 246 VRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGK-QESCAP----GAVVKARPMEGSLEEP 300
K+ EK ++ E+ K+R +EID K ++S P A ++R
Sbjct: 441 HEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRR 500
Query: 301 QETSHSGSDKEHRDVER-SQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGP 359
+ S S S + + ++R S S R D R H ER R R K
Sbjct: 501 RSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMR--KSS 558
Query: 360 GQDRGKKGSQDSGAPGEAMER-----LGRAQRCDDSPAPRKE 396
GK+ + + + E ++ DD APR E
Sbjct: 559 NDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTE 600
Score = 29.6 bits (65), Expect = 5.7
Identities = 25/101 (24%), Positives = 41/101 (40%), Gaps = 14/101 (13%)
Query: 178 ARRTTPLLEYIKNRKLEKQRIREEKREERRR--------------RELEKKRLREEEKRR 223
+R +P K++K EK+R +R ER R +LEK +EK
Sbjct: 520 SRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEH 579
Query: 224 RREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEK 264
+E + KE D + +E +I+ + EE + K
Sbjct: 580 NKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNEENLSTK 620
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
[Homo sapiens]
Length = 508
Score = 77.4 bits (189), Expect = 2e-14
Identities = 63/253 (24%), Positives = 111/253 (43%), Gaps = 15/253 (5%)
Query: 189 KNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRI 248
K+R R R +++ RR + KKR + E+R+ R + K D ++KI EKE
Sbjct: 216 KHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVK 275
Query: 249 KLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGS 308
+ ++ E+ E EK KERG+ D +++ + + E E +E H
Sbjct: 276 EKDREKEREREKEREKEKERGKNKDRDKEREKD-------REKDKEKDREREREKEHEKD 328
Query: 309 DKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGS 368
+ ++ E+ +E+E E R D +R + + R RS + R + ++R ++ S
Sbjct: 329 RDKEKEKEQDKEKEREKDRSKEIDEKRKK--DKKSRTPPRSYNASRRSRSSSRERRRRRS 386
Query: 369 QDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPALQLYDPGARFRARECGGNRRICK 428
+ S + + R + SP+PR KD+ + D + R RE + R K
Sbjct: 387 RSSSRSPRTSKTIKR--KSSRSPSPRSRN--KKDKKREKERDHISERRERERSTSMR--K 440
Query: 429 AEGSGTGPEKREE 441
+ G EK E+
Sbjct: 441 SSNDRDGKEKLEK 453
Score = 69.3 bits (168), Expect = 7e-12
Identities = 61/222 (27%), Positives = 101/222 (45%), Gaps = 14/222 (6%)
Query: 186 EYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKE 245
E IK ++ K++ RE++RE + RE EK+R + +++ + RE++R K KE D++++ EKE
Sbjct: 266 EKIKEKERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDRERE-REKE 324
Query: 246 VRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGK-QESCAP----GAVVKARPMEGSLEEP 300
K+ EK ++ E+ K+R +EID K ++S P A ++R
Sbjct: 325 HEKDRDKEKEKEQDKEKEREKDRSKEIDEKRKKDKKSRTPPRSYNASRRSRSSSRERRRR 384
Query: 301 QETSHSGSDKEHRDVER-SQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGP 359
+ S S S + + ++R S S R D R H ER R R K
Sbjct: 385 RSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERRERERSTSMR--KSS 442
Query: 360 GQDRGKKGSQDSGAPGEAMER-----LGRAQRCDDSPAPRKE 396
GK+ + + + E ++ DD APR E
Sbjct: 443 NDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTE 484
Score = 29.6 bits (65), Expect = 5.7
Identities = 25/101 (24%), Positives = 41/101 (40%), Gaps = 14/101 (13%)
Query: 178 ARRTTPLLEYIKNRKLEKQRIREEKREERRR--------------RELEKKRLREEEKRR 223
+R +P K++K EK+R +R ER R +LEK +EK
Sbjct: 404 SRSPSPRSRNKKDKKREKERDHISERRERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEH 463
Query: 224 RREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEK 264
+E + KE D + +E +I+ + EE + K
Sbjct: 464 NKEPDSSVSKEVDDKDAPRTEENKIQHNGNCQLNEENLSTK 504
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 74.3 bits (181), Expect = 2e-13
Identities = 60/222 (27%), Positives = 105/222 (47%), Gaps = 21/222 (9%)
Query: 154 EEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKN-RKLEKQRIREEKREE-----RR 207
EEEK ET+L + E K +E +R L E + RKLE+Q +R E++EE R
Sbjct: 241 EEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRL 300
Query: 208 RRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKE 267
RRE + +R +EEE+R ++EE R +++ ++Q++ E+++R ++ E+ E+ + +E
Sbjct: 301 RREQQLRRKQEEERREQQEERREQQERREQQEERREQQLR---REQEERREQQLRREQEE 357
Query: 268 RGEEIDTGGGKQESCAPGAVVKARPM--------EGSLEEPQETSHSGSDKEHRDVERSQ 319
E ++E + + + + E L Q+ + + + R Q
Sbjct: 358 ERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQ 417
Query: 320 EQESEAQRYHVDDGRRHRAHHEPE----RLSRRSEDEQRWGK 357
+ E Q + RH HE E RL R E+ + W K
Sbjct: 418 QLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRDWLK 459
Score = 65.9 bits (159), Expect = 7e-11
Identities = 59/248 (23%), Positives = 119/248 (47%), Gaps = 33/248 (13%)
Query: 132 DGYIFLDSKDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYI-KN 190
D ++ ++ E + LE + + ++ + + LLGE + + RE RR + +
Sbjct: 1237 DNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEE 1296
Query: 191 RKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQ-----------K 239
+LE++ +E KR +R+ +E EK+ LREE + +RR +E +K ++Q +
Sbjct: 1297 EQLEREEQKEAKRRDRKSQE-EKQLLREEREEKRRRQETDRKFREEEQLLQEREEQPLRR 1355
Query: 240 KIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSL-- 297
+ +++ R + L+ E+G + E+ + R +E + K+E ++ + E L
Sbjct: 1356 QERDRKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKEEQ-----QLRCQEREQQLRQ 1410
Query: 298 -------EEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGR-----RHRAHHEPERL 345
EE Q+ S D++ R+ E Q + E +R +++ + RHR E E+L
Sbjct: 1411 DRDRKFREEEQQLSRQERDRKFRE-EEQQVRRQERERKFLEEEQQLRQERHRKFREEEQL 1469
Query: 346 SRRSEDEQ 353
+ E++Q
Sbjct: 1470 LQEREEQQ 1477
Score = 64.3 bits (155), Expect = 2e-10
Identities = 55/205 (26%), Positives = 96/205 (46%), Gaps = 18/205 (8%)
Query: 154 EEEKTSANPETLLGEMEAKTRELIAR---RTTPLLEYIKNRKLEKQRIREEKREERRRRE 210
E E+ A E L +T E R LLE + + EKQ+ R E R++R +E
Sbjct: 182 EREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRE-RQDRVFQE 240
Query: 211 LEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPE-KGEEPTTEKPKERG 269
E+K R+ E R+EEE+ +++E +Q+++ E+E +++ L++ E + E E+ ++R
Sbjct: 241 EEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRL 300
Query: 270 EEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYH 329
KQE + R + E QE ++ + + R QE+ E Q
Sbjct: 301 RREQQLRRKQEE-------ERREQQEERREQQERREQQEERREQQLRREQEERREQQL-- 351
Query: 330 VDDGRRHRAHHEPERLSRRSEDEQR 354
RR + E+ RR ++E+R
Sbjct: 352 ----RREQEEERREQQLRREQEEER 372
Score = 64.3 bits (155), Expect = 2e-10
Identities = 67/289 (23%), Positives = 129/289 (44%), Gaps = 33/289 (11%)
Query: 149 ETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRR 208
E C EEE+ E LL E K R R E ++ E+Q +REE E+RRR
Sbjct: 1107 ERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQE--EEQLLREEP-EKRRR 1163
Query: 209 RELEKKR-------------LREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPE 255
+ELE++ LREE+++RR+E ER ++E + Q++ ++ R + +
Sbjct: 1164 QELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDL 1223
Query: 256 KGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGS----LEEPQETSHSGSDKE 311
K + ++ R ++ G + E + R +E S + Q+ H +++
Sbjct: 1224 KWQWEPEKENAVRDNKVYCKGRENE--------QFRQLEDSQLRDRQSQQDLQHLLGEQQ 1275
Query: 312 HRDVERSQEQESEAQRYHVDDGRRHRAHH-EPERLSRRSEDEQRWGKGPGQDRGKKGSQD 370
RD E+ + + + R+ ++ + R E +R R+S++E++ + +++ ++ D
Sbjct: 1276 ERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLREEREEKRRRQETD 1335
Query: 371 SGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPALQLYDPGARFRARE 419
+ E Q ++ P R+ER L+ + G +F E
Sbjct: 1336 R----KFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEE 1380
Score = 60.8 bits (146), Expect = 2e-09
Identities = 69/283 (24%), Positives = 122/283 (43%), Gaps = 44/283 (15%)
Query: 155 EEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKK 214
E++ E + ++ + + R E + R+ EK R+ +E+RE+R +RE E++
Sbjct: 516 EQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEK-RLEQERREQRLKREQEER 574
Query: 215 R---LREEEKRRR---------REEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTT 262
R L+ EE+RR+ R E+R K++E ++ ++ +E R+K ++PE+
Sbjct: 575 RDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLK-REEPEEERRQQL 633
Query: 263 EKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQ- 321
K +E+ E +++ +K E LE+ + H +E E QEQ
Sbjct: 634 LKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQA 693
Query: 322 ---------------ESEA--------QRYHVDDGRRHRAHHEPERLSRRSEDEQRW--- 355
ESEA R +G+R R E +R RR E E +W
Sbjct: 694 RERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKR--RRRESELQWQEE 751
Query: 356 GKGPGQDRGKKGSQDSGAPGEAMERLGRA-QRCDDSPAPRKER 397
+ Q + ++ +D +A E+ R QR P R++R
Sbjct: 752 ERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQR 794
Score = 60.5 bits (145), Expect = 3e-09
Identities = 74/276 (26%), Positives = 123/276 (44%), Gaps = 49/276 (17%)
Query: 154 EEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEK---REERRRRE 210
EEE+ E LLGE E +TR + ++LE+Q +EE+ EE+ RE
Sbjct: 1052 EEEELQQEEEQLLGE-ERETR--------------RRQELERQYRKEEELQQEEEQLLRE 1096
Query: 211 LEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEK------ 264
+KR R+E +R+ REEE +++E ++ EK R +L ++ + EE E+
Sbjct: 1097 EPEKRRRQERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLRE 1156
Query: 265 --PKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQE 322
K R +E++ ++E + E L E QE ++++R+ E Q Q+
Sbjct: 1157 EPEKRRRQELERQYREEEEL-------QQEEEQLLREEQEKRRQERERQYREEEELQRQK 1209
Query: 323 SEAQRYHVDDGRRH-RAHHEPER---------LSRRSEDEQRWGKGPGQDRGKKGSQD-S 371
+ QRY +D R + EPE+ + E+EQ Q R ++ QD
Sbjct: 1210 RK-QRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQDLQ 1268
Query: 372 GAPGEAMERLGRAQR----CDDSPAPRKERLANKDR 403
GE ER +R D P +E+L +++
Sbjct: 1269 HLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQ 1304
Score = 58.2 bits (139), Expect = 2e-08
Identities = 53/203 (26%), Positives = 104/203 (51%), Gaps = 18/203 (8%)
Query: 154 EEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEK 213
+++K E LLGE K R R E + ++ E+Q +REE RE+RRR+E E+
Sbjct: 962 KDKKLQQKEEQLLGEEPEKRRR--QEREKKYREEEELQQEEEQLLREE-REKRRRQEWER 1018
Query: 214 KRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPT--TEKPKERGEE 271
+ +++E ++EEE+ ++E +K +++ E+E + + ++ ++ EE E+ R +E
Sbjct: 1019 QYRKKDE--LQQEEEQLLREEREK-RRLQERERQYREEEELQQEEEQLLGEERETRRRQE 1075
Query: 272 IDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVD 331
++ K+E ++ + EEP++ +++ R+ E Q++E + R
Sbjct: 1076 LERQYRKEEE------LQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLR---- 1125
Query: 332 DGRRHRAHHEPERLSRRSEDEQR 354
+ R R E ER R E+ Q+
Sbjct: 1126 EEREKRRRQELERQYREEEEVQQ 1148
Score = 57.8 bits (138), Expect = 2e-08
Identities = 75/333 (22%), Positives = 149/333 (44%), Gaps = 42/333 (12%)
Query: 118 FRNPDDILLFRDRFDGYIFLDSKDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRE-- 175
FR + +L ++R + + +D +KFLE E++ + E E +++E
Sbjct: 1463 FREEEQLL--QEREEQQLHRQERD---RKFLEE---EQQLRRQERDRKFREQELRSQEPE 1514
Query: 176 -LIARRTTPLLEYIKNRKL--EKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKK 232
L + RK E+Q++R ++R ++RR++ ++K EE+ R+ REE++ +
Sbjct: 1515 RKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSR 1574
Query: 233 KETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARP 292
+E D++ ++ E++VR + ++ K E + ++ G Q+ K R
Sbjct: 1575 QERDRKFRLEEQKVRRQ--EQERKFMEDEQQLRRQEG---------QQQLRQERDRKFRE 1623
Query: 293 MEGSLEEPQETSHSGSDKEHRDVERS---QEQESEAQRYHVDDGRRHRAHHEPERLSRRS 349
E L+E +E +++ + +E + QE E Q H R R E E+L +
Sbjct: 1624 DEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRH----DRDRKFREEEQLLQEG 1679
Query: 350 EDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQR-CDDSPAPRKERLANKDRPALQL 408
E++Q Q+R +K ++ + + R R ++ + R++ L K R QL
Sbjct: 1680 EEQQL----RRQERDRKFREEE----QQLRRQERERKFLQEEQQLRRQELERKFREEEQL 1731
Query: 409 YDPGARFRARECGGNRRICKAEGSGTGPEKREE 441
+ + R R+I + E PE+ E+
Sbjct: 1732 RQETEQEQLRRQERYRKILEEE--QLRPEREEQ 1762
Score = 56.6 bits (135), Expect = 4e-08
Identities = 59/253 (23%), Positives = 112/253 (44%), Gaps = 27/253 (10%)
Query: 189 KNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRI 248
+ R L ++ +E++R +RR RE E + L EEE+ +RRE + ++E D ++ E+ R
Sbjct: 807 EQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERR-RS 865
Query: 249 KLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESC-APGAVVKARPMEGSLEEPQETSHSG 307
+ ++ +K E+ K R + QE +++ E EE ++
Sbjct: 866 QEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQE 925
Query: 308 SDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRR-----SEDEQRWGKGP--- 359
++++R+ E+ Q++E + R + R R E ER R+ ++EQ G+ P
Sbjct: 926 QERQYREEEQLQQEEEQLLR----EEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKR 981
Query: 360 -GQDRGKKGSQDSGAPGEAMERL------------GRAQRCDDSPAPRKERLANKDRPAL 406
Q+R KK ++ E + L R R D +E+L ++R
Sbjct: 982 RRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKR 1041
Query: 407 QLYDPGARFRARE 419
+L + ++R E
Sbjct: 1042 RLQERERQYREEE 1054
Score = 55.5 bits (132), Expect = 1e-07
Identities = 61/222 (27%), Positives = 102/222 (45%), Gaps = 28/222 (12%)
Query: 186 EYIKNRKLEKQRIREEKREERRRREL---EKKRLREE-EKRRRREEERCKKKETDKQKKI 241
E ++ + EK+R +E++R+ R +L E++ LREE EKRRR+E ER +K+ KK+
Sbjct: 911 EELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKD----KKL 966
Query: 242 AEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQ 301
+KE ++ L ++PEK EK EE+ ++E K R E
Sbjct: 967 QQKEEQL-LGEEPEKRRRQEREKKYREEEELQQ---EEEQLLREEREKRRRQE------W 1016
Query: 302 ETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQ 361
E + D+ ++ E+ +E E +R R R + E E L + E+EQ G+
Sbjct: 1017 ERQYRKKDELQQEEEQLLREEREKRRLQ----ERERQYREEEEL--QQEEEQLL----GE 1066
Query: 362 DRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDR 403
+R + Q+ E L + + P K R ++R
Sbjct: 1067 ERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRRQERER 1108
Score = 54.3 bits (129), Expect = 2e-07
Identities = 55/245 (22%), Positives = 116/245 (47%), Gaps = 21/245 (8%)
Query: 163 ETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKR 222
ET E E + ++L + E + E++R ++E+RE++ RRE E++R E+ +
Sbjct: 463 ETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERR--EQRLK 520
Query: 223 RRREEERCKKK-ETDKQKKIAEKEVRIKLLKKPEK---GEEPTTEKPKERGEEIDTGGGK 278
R+ EEER +++ +++Q + ++E R +LLK+ E+ +E ++ K EE K
Sbjct: 521 RQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLK 580
Query: 279 QESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRA 338
+E + R E+ + +E +E+ + +E +R ++ RR +
Sbjct: 581 REE-------ERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQL 633
Query: 339 HHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERL 398
E+ RR + +R + + R K+ ++ ERL + + + R++ L
Sbjct: 634 LKSEEQEERRQQQLRREQQERREQRLKREEEE--------ERLEQRLKREHEEERREQEL 685
Query: 399 ANKDR 403
A +++
Sbjct: 686 AEEEQ 690
Score = 53.1 bits (126), Expect = 5e-07
Identities = 47/170 (27%), Positives = 79/170 (46%), Gaps = 12/170 (7%)
Query: 194 EKQRIREEKREERRRRELEKKRLREEEKRRRREEER----CKKKETDKQKKIAEKEVRIK 249
EKQ E++ +RR EL ++R +E+ RR EE CK ET++ E+ R +
Sbjct: 156 EKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPD-EEQLRRRE 214
Query: 250 LLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSD 309
LL+ KG E ++ +ER + + ++E V++ + EEPQ +
Sbjct: 215 LLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEE 274
Query: 310 KEH-----RDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQR 354
+E R R + QE E Q+ + ++ R E ER R ++E+R
Sbjct: 275 EEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER--REQQEERR 322
Score = 51.2 bits (121), Expect = 2e-06
Identities = 58/255 (22%), Positives = 116/255 (45%), Gaps = 30/255 (11%)
Query: 190 NRKLEKQRIREE----KREERRRRELEKKR-LREEEKRRRREEERCKKKETDKQ------ 238
+R+ ++ REE +R+ER R+ LE+++ LR+E R+ REEE+ ++ ++Q
Sbjct: 1424 SRQERDRKFREEEQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQER 1483
Query: 239 -KKIAEKEVRIKLLKKPEK--GEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEG 295
+K E+E +++ ++ K +E +++P+ + E + +Q+ K E
Sbjct: 1484 DRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQR-----KFLQEEQ 1538
Query: 296 SL--EEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRS---- 349
L +E + D++ R+ E+ +++ E Q + R+ R + R +
Sbjct: 1539 QLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFM 1598
Query: 350 EDEQRWGKGPG-----QDRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRP 404
EDEQ+ + G Q+R +K +D E E+ Q D + +L ++R
Sbjct: 1599 EDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQERE 1658
Query: 405 ALQLYDPGARFRARE 419
+D +FR E
Sbjct: 1659 QQLRHDRDRKFREEE 1673
Score = 50.4 bits (119), Expect = 3e-06
Identities = 62/252 (24%), Positives = 121/252 (48%), Gaps = 32/252 (12%)
Query: 122 DDILLFRDRFDGYIFLDSKDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRT 181
+D L ++R + + +D +KFLE + + + L + + K RE
Sbjct: 1623 EDEQLLQEREEQQLHRQERD---RKFLEEE--PQLRRQEREQQLRHDRDRKFRE-----E 1672
Query: 182 TPLLEYIKNRKLEKQ----RIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETD- 236
LL+ + ++L +Q + REE+ ++ RR+E E+K L+EE++ RR+E ER ++E
Sbjct: 1673 EQLLQEGEEQQLRRQERDRKFREEE-QQLRRQERERKFLQEEQQLRRQELERKFREEEQL 1731
Query: 237 ----KQKKIAEKEVRIKLLK----KPEKGEEPTTEKPKER----GEEIDTGGGKQESCAP 284
+Q+++ +E K+L+ +PE+ E+ + ++R E++ +Q+ +
Sbjct: 1732 RQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQ 1791
Query: 285 GAVVKARPMEGSLE--EPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHE- 341
+ K R E + E Q+ D ++R E + E + QR + R++RA +
Sbjct: 1792 ESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQF 1851
Query: 342 -PERLSRRSEDE 352
+ SRR E E
Sbjct: 1852 ATQEKSRREEQE 1863
Score = 50.1 bits (118), Expect = 4e-06
Identities = 56/244 (22%), Positives = 108/244 (44%), Gaps = 35/244 (14%)
Query: 154 EEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEK 213
E ++ E L E + + L + E + + E+Q +E ++E+ RR+E +
Sbjct: 1688 ERDRKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYR 1747
Query: 214 KRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEID 273
K L EE+ R REE++ +++E D +K E+E +L ++ E+ + + E ++ EE
Sbjct: 1748 KILEEEQLRPEREEQQLRRQERD--RKFREEE---QLRQEREEQQLRSQESDRKFREEEQ 1802
Query: 274 TGGGKQESCAPGAVVKARPMEG-----------SLEEPQETSHSGSDKEHRDVERSQEQE 322
++E + RP + LEE ++ D+++R E+ QE
Sbjct: 1803 LRQEREEQ-------QLRPQQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQE 1855
Query: 323 S---EAQRYHVDDGRRHRAHHE----PERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPG 375
E Q ++ ++ R E E + R+ ++EQR + G+ SQ+ G
Sbjct: 1856 KSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQR-----HRQVGEIKSQEGKGHG 1910
Query: 376 EAME 379
+E
Sbjct: 1911 RLLE 1914
Score = 48.9 bits (115), Expect = 9e-06
Identities = 46/229 (20%), Positives = 99/229 (43%), Gaps = 36/229 (15%)
Query: 155 EEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRE---- 210
+++ E GE +++ +E + +R ++ +L +QR ++REERR E
Sbjct: 139 QKRQEQERELAEGEEQSEKQERLEQRDRQR----RDEELWRQRQEWQEREERRAEEEQLQ 194
Query: 211 ---------------------LEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIK 249
LE +R EEK+++R E + + + +++K+ ++E ++
Sbjct: 195 SCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLR 254
Query: 250 LLKKPEKGEEPTTEKPKERGEE----IDTGGGKQESCAPGAVVKARPMEGSLEEPQETSH 305
++ + EEP ++ + EE ++ ++E + E L QE
Sbjct: 255 KEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEER 314
Query: 306 SGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQR 354
+E R+ + +EQ+ E + + RR + ++L R E+E+R
Sbjct: 315 REQQEERREQQERREQQEERREQQL---RREQEERREQQLRREQEEERR 360
Score = 48.9 bits (115), Expect = 9e-06
Identities = 54/259 (20%), Positives = 112/259 (43%), Gaps = 14/259 (5%)
Query: 153 VEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREE--KREERRRRE 210
+ E+ + L E E + RE RR + + E+Q RE+ +RE++ RRE
Sbjct: 339 LRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRRE 398
Query: 211 LEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGE 270
+ +R E++ RR ++ R ++ ++Q + ++E R + + E+ E+ + +ER +
Sbjct: 399 QQLRR--EQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERRD 456
Query: 271 EIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHV 330
+ K+E + R + ++ +E E + QE+ + R
Sbjct: 457 WL-----KREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQ 511
Query: 331 DDGRRHR--AHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRCD 388
++ R R E ERL +R EQ+ + + R + ++ + +E+ R QR
Sbjct: 512 EERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREE---EKRLEQERREQRLK 568
Query: 389 DSPAPRKERLANKDRPALQ 407
R+++L ++ Q
Sbjct: 569 REQEERRDQLLKREEERRQ 587
Score = 48.5 bits (114), Expect = 1e-05
Identities = 52/225 (23%), Positives = 104/225 (46%), Gaps = 13/225 (5%)
Query: 143 EYKKFLETYCVEEEKTSAN---PETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRI- 198
E+++ E EE+ S E E + + REL+ R E + R+ + R+
Sbjct: 179 EWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRERQDRVF 238
Query: 199 REEKREERRRREL----EKKRLREEE--KRR--RREEERCKKKETDK-QKKIAEKEVRIK 249
+EE+ +E R+RE E+++L+EEE ++R + EEE+ +K E + +++ E+E + +
Sbjct: 239 QEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRERQEEEQQQQ 298
Query: 250 LLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSD 309
L++ ++ E+ +E+ EE ++E + R + E Q +
Sbjct: 299 RLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRREQEERREQQLRREQEEE 358
Query: 310 KEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQR 354
+ + + R QE+E Q+ + R E+ RR + +R
Sbjct: 359 RREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRR 403
Score = 48.1 bits (113), Expect = 2e-05
Identities = 60/248 (24%), Positives = 113/248 (45%), Gaps = 54/248 (21%)
Query: 153 VEEEKTSA--NPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQ--RIREEKREERRR 208
++EEK + E+LL + + +E RR P ++R+LE++ + R +KR+E+ R
Sbjct: 95 LDEEKRARCDGKESLLQD---RRQEEDQRRFEP-----RDRQLEEEPGQRRRQKRQEQER 146
Query: 209 R------ELEKKRLREEEKRRRREEE--RCKKKETDKQKKIAEKEV-------------- 246
+ EK+ E+ R+RR+EE R +++ +++++ AE+E
Sbjct: 147 ELAEGEEQSEKQERLEQRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPD 206
Query: 247 -----RIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQ 301
R +LL+ KG E ++ +ER + + ++E V++ + EEPQ
Sbjct: 207 EEQLRRRELLELRRKGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQ 266
Query: 302 ETSHSGSDKEH-RDVERS------QEQESEAQRYH--------VDDGRRHRAHHEPERLS 346
++E R +ER QE+E + QR ++ RR + E+
Sbjct: 267 RQRELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQE 326
Query: 347 RRSEDEQR 354
RR + E+R
Sbjct: 327 RREQQEER 334
Score = 48.1 bits (113), Expect = 2e-05
Identities = 53/208 (25%), Positives = 100/208 (48%), Gaps = 25/208 (12%)
Query: 156 EKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIR---EEKREERRRRELE 212
E+ + L E E + + + R+ E ++ R +Q++R EE+RE+ +RE E
Sbjct: 498 EQQERREQQLRREQEERREQRLKRQEEE--ERLQQRLRSEQQLRREQEERREQLLKRE-E 554
Query: 213 KKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEI 272
+KRL E+E+R E+R K+++ +++ ++ ++E + + + EE ++ K EE+
Sbjct: 555 EKRL-EQERR----EQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKR--EEV 607
Query: 273 DTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVE-RSQEQESEAQRYHVD 331
+ +QE + + P E E Q+ S +E R + R ++QE QR +
Sbjct: 608 ER--LEQEERREQRLKREEPEE---ERRQQLLKSEEQEERRQQQLRREQQERREQRLKRE 662
Query: 332 ------DGRRHRAHHEPERLSRRSEDEQ 353
+ R R H E R +E+EQ
Sbjct: 663 EEEERLEQRLKREHEEERREQELAEEEQ 690
Score = 47.4 bits (111), Expect = 3e-05
Identities = 63/298 (21%), Positives = 127/298 (42%), Gaps = 37/298 (12%)
Query: 137 LDSKDPEYKKFLETYC-VEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEK 195
+ S+ P+++ LE+ + K + P G+ + +E RR L++ + + +
Sbjct: 697 IKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHR 756
Query: 196 QRIREEKR-------------EERRRRELEKKRLREEEKRRRREEERCKK------KETD 236
Q+ EE+R E R+R + LRE+ +R+ R EER ++ +E +
Sbjct: 757 QQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEE 816
Query: 237 KQKKIAEKEVRIKLLKKPEKGEE-PTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEG 295
K+++ ++ R K L+ E+ E+ E+ ++ EE D QE + +
Sbjct: 817 KEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRW 876
Query: 296 SLEEPQE-------TSHSGSDKEHRDVERSQEQESEAQRYHVDDGRR---HRAHHEPERL 345
LEE ++ + ++ ++ + QE+E E QR + RR R + E E+L
Sbjct: 877 QLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQL 936
Query: 346 SRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDR 403
+ E R ++R K+ Q+ ++L + + P K R +++
Sbjct: 937 QQEEEQLLR------EEREKRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREK 988
Score = 46.2 bits (108), Expect = 6e-05
Identities = 40/204 (19%), Positives = 91/204 (44%), Gaps = 16/204 (7%)
Query: 195 KQRIREEKREE--RRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLK 252
K+ + +++R+E +RR E ++L EE +RRR++ + +++E + ++ +EK+ R++
Sbjct: 106 KESLLQDRRQEEDQRRFEPRDRQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLEQRD 165
Query: 253 KPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEH 312
+ + EE ++ + + E +Q G + P E L + +E
Sbjct: 166 RQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREE 225
Query: 313 RDVERSQEQESEAQRYHVDDGRRHRA----------HHEPERLSRRSEDEQRWGKGPGQD 362
+ +R + Q+ Q + R+ EP+R E+E++ K Q+
Sbjct: 226 KQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQE 285
Query: 363 RGKKGSQDSGAPGEAMERLGRAQR 386
++ ++ + +RL R Q+
Sbjct: 286 LRRERQEEE----QQQQRLRREQQ 305
Score = 45.1 bits (105), Expect = 1e-04
Identities = 44/189 (23%), Positives = 82/189 (43%), Gaps = 12/189 (6%)
Query: 174 RELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKR---------LREEEKRRR 224
RE RR L + R+ E++ R E++ E+ RRE KR REEE R
Sbjct: 409 REQQLRREQQLRREQQLRR-EQEEERHEQKHEQERREQRLKREQEERRDWLKREEETERH 467
Query: 225 REEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAP 284
+E R ++ + D++++ E+ ++++ ++ E+ E + +E+ E + +QE
Sbjct: 468 EQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEE--E 525
Query: 285 GAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPER 344
+ + E L QE K + QE+ + + ++ R E ER
Sbjct: 526 ERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEER 585
Query: 345 LSRRSEDEQ 353
+R + EQ
Sbjct: 586 RQQRLKREQ 594
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 72.8 bits (177), Expect = 6e-13
Identities = 67/234 (28%), Positives = 112/234 (47%), Gaps = 39/234 (16%)
Query: 168 EMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKRE-ERRRRELEKKRLREEEKRRRRE 226
EME R+LI+R + + K + EK + +E++E E+ RRE E++R RE E RR RE
Sbjct: 268 EMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERE-RRERE 326
Query: 227 EERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGA 286
ER +++E +K+K+ E+E ++ ++ + T E+ ++R E D
Sbjct: 327 REREREREREKEKE-RERE------RERDRDRDRTKERDRDRDRERD------------- 366
Query: 287 VVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLS 346
+ R E S + ++ S S R+ ER +E+E E +R + R R E ER
Sbjct: 367 --RDRDRERSSDRNKDRSRSREKSRDRERERERERERERERERERERERER-ERERERER 423
Query: 347 RRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLAN 400
R +D++R DR + +A ER ++ + A +ERL N
Sbjct: 424 EREKDKKR-------DREEDEE-------DAYERRKLERKLREKEAAYQERLKN 463
Score = 66.2 bits (160), Expect = 6e-11
Identities = 82/325 (25%), Positives = 139/325 (42%), Gaps = 40/325 (12%)
Query: 143 EYKKFLETYC-VEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREE 201
E KF +T+ +EEEK E E E + RE R E + R+ E++R RE+
Sbjct: 280 EISKFRDTHKKLEEEKGKKEKERQEIEKERRERERERERERERRE--REREREREREREK 337
Query: 202 KREERRRRELEKKRLREEEKRRRREEERCKKKETDK-------------------QKKIA 242
++E R RE ++ R R +E+ R R+ ER + ++ ++ +++
Sbjct: 338 EKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERER 397
Query: 243 EKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQE 302
E+E + ++ E+ E E+ +ER E D ++E + R +E L E +
Sbjct: 398 EREREREREREREREREREREREREREREKDKKRDREED--EEDAYERRKLERKLREKEA 455
Query: 303 TSHSG-SDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQ 361
+ E R+ ++++E E EA+R ++ RR E +RL ED P
Sbjct: 456 AYQERLKNWEIRERKKTREYEKEAER---EEERRREMAKEAKRLKEFLEDYDDDRDDPKY 512
Query: 362 DRG---KKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPALQLYDPGARFRAR 418
RG +K +D EA ER + ++ + ++RL + P DP A +
Sbjct: 513 YRGSALQKRLRDREKEMEADERDRKREK--EELEEIRQRLLAEGHP-----DPDAELQRM 565
Query: 419 ECGGNRRICKAEGSGTGPEKREEAE 443
E RR + PE EE E
Sbjct: 566 EQEAERR--RQPQIKQEPESEEEEE 588
Score = 61.2 bits (147), Expect = 2e-09
Identities = 55/227 (24%), Positives = 102/227 (44%), Gaps = 24/227 (10%)
Query: 189 KNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKE--- 245
++R EK R RE +RE R RE E++R RE E+ R RE ER +++E DK++ E E
Sbjct: 381 RSRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDA 440
Query: 246 -VRIKLLKKPEKGEEPTTEKPK-------ERGEEIDTGGGKQESCAPGAVVKARPMEGSL 297
R KL +K + E E+ K ++ E + ++E +A+ ++ L
Sbjct: 441 YERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFL 500
Query: 298 E-------EPQETSHSGSDKEHRDVER---SQEQESEAQRYHVDDGRRH---RAHHEPER 344
E +P+ S K RD E+ + E++ + ++ +++ R+ H +P+
Sbjct: 501 EDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDA 560
Query: 345 LSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRCDDSP 391
+R E E + P + + ++ E E+ ++ P
Sbjct: 561 ELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEP 607
Score = 43.1 bits (100), Expect = 5e-04
Identities = 43/166 (25%), Positives = 72/166 (43%), Gaps = 23/166 (13%)
Query: 168 EMEAKTRELIARRTTPLLEY-IKNRKLEKQRIREEKREERRRRELEK--KRLREE----- 219
++E K RE A L + I+ RK ++ +E +REE RRRE+ K KRL+E
Sbjct: 445 KLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYD 504
Query: 220 --------------EKRRRREEERCKKKETDKQKKIAE-KEVRIKLLKKPEKGEEPTTEK 264
+KR R E+ + E D++++ E +E+R +LL + + ++
Sbjct: 505 DDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQR 564
Query: 265 PKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDK 310
++ E KQE + + + E EEP E K
Sbjct: 565 MEQEAERRRQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQK 610
Score = 37.7 bits (86), Expect = 0.021
Identities = 36/144 (25%), Positives = 60/144 (41%), Gaps = 15/144 (10%)
Query: 168 EMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKR---LREEEKRRR 224
EMEA R+ +R LE I+ R L + + +R +E E++R +++E +
Sbjct: 528 EMEADERD--RKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERRRQPQIKQEPESEE 585
Query: 225 REEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAP 284
EEE+ +K+E ++ E+E K KP T +P + + G P
Sbjct: 586 EEEEKQEKEEKREEPMEEEEEPEQKPCLKP-------TLRPISSAPSVSSASGNATPNTP 638
Query: 285 GAVVKAR---PMEGSLEEPQETSH 305
G P E S ++ Q H
Sbjct: 639 GDESPCGIIIPHENSPDQQQPEEH 662
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 72.8 bits (177), Expect = 6e-13
Identities = 65/262 (24%), Positives = 118/262 (45%), Gaps = 24/262 (9%)
Query: 140 KDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIR 199
+D + K E E + ++ ET + + R+ R E + ++QR
Sbjct: 232 RDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRT 291
Query: 200 EEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEE 259
E RE R+RE +++R RE E+ R+RE ER +++E ++Q +E K+ E+ +
Sbjct: 292 ERDRETERKRERQRERERERERNRKRERERERERERERQ-----RETERDREKERERKRK 346
Query: 260 PTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQ 319
TE +ER + G +Q R E E ++++ ++E RD +R +
Sbjct: 347 RQTEMDRERNRQTGREGRRQAE---------RERERERERDRQSAREREERE-RDRDRDR 396
Query: 320 EQESEAQRYHVDDGRRHRAHHEPERLSRRSED-EQRWGKGPGQDRGKKGSQDSGAPGEAM 378
++E E Q DG+R E E+ R +D E G+ G++R K+ ++ +
Sbjct: 397 QKERERQTEKDRDGQR-----ETEKQREREKDRESERGRERGREREKQKGRERDRERQTD 451
Query: 379 ERLGRAQRCDD---SPAPRKER 397
+ GR ++ +P PR R
Sbjct: 452 RQAGRQRKRSTLYVNPPPRTAR 473
Score = 72.0 bits (175), Expect = 1e-12
Identities = 60/234 (25%), Positives = 109/234 (46%), Gaps = 23/234 (9%)
Query: 189 KNRKLEKQRIREEKREER---RRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKE 245
+NR+ E++R RE+++ ER R+RE +++ R ++ R RE +R ++KE ++Q E++
Sbjct: 56 RNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKERERQTD-RERD 114
Query: 246 VRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGA-------VVKARPMEGSLE 298
+ + + +K E TE+ ERG + T G ++ A + R +
Sbjct: 115 RQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERN 174
Query: 299 EPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPE------RLSRRSEDE 352
+E + +E R+ ER +E+E++ + H + GR E E R + R D
Sbjct: 175 RQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDR 234
Query: 353 QRWGKGPGQDRGKKGSQDSGAPGEA---MERLGRAQRCDDSPAPRKERLANKDR 403
QR + ++R K+ ++ + E ER R D +KER DR
Sbjct: 235 QRKTE---REREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDR 285
Score = 68.9 bits (167), Expect = 9e-12
Identities = 46/178 (25%), Positives = 85/178 (47%), Gaps = 15/178 (8%)
Query: 189 KNRKLEKQRIREEK------------REERRRRELEKKRLREEEKRRRREEERCKKKETD 236
+NR+ E++R E + RE R+R+ EK+R R+ ++ R+R+ ER ++KE +
Sbjct: 121 RNRQKERERETEREGERGRDRQTDGQRERERQRDAEKERERQTDRERQRQTERNRQKERE 180
Query: 237 KQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGS 296
++K E+ R + +K K E+ +E+ +ER E +T + E+ + R +
Sbjct: 181 REKNRQERRERERQREKENKTEDRHSERGRERERERET---ETETERKRQTDRERDRQRK 237
Query: 297 LEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQR 354
E +E R+ ER +E+E E R D R+ + +R +R + R
Sbjct: 238 TEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTERDR 295
Score = 67.0 bits (162), Expect = 3e-11
Identities = 65/260 (25%), Positives = 114/260 (43%), Gaps = 27/260 (10%)
Query: 189 KNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQK-----KIAE 243
+ R EK+R R+ RE R+RE E+ R +E E+ RE ER + ++TD Q+ + AE
Sbjct: 97 RQRDREKERERQTDRERDRQREKERNRQKERERETEREGERGRDRQTDGQRERERQRDAE 156
Query: 244 KEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQET 303
KE + ++ ++ E +K +ER + +QE + R + E E
Sbjct: 157 KERERQTDRERQRQTERNRQKEREREK------NRQER-------RERERQREKENKTED 203
Query: 304 SHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDR 363
HS + R+ ER +E E+E +R D R R +++E E+ + +D+
Sbjct: 204 RHS---ERGRERERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDK 260
Query: 364 GKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPALQLYDPGARFRARECGGN 423
++ +D + ++ R ++ D R ER +R + R R RE N
Sbjct: 261 ERERERDRDRDRDRRQK-ERERQTDRKRQRRTERDRETERKRER-----QRERERERERN 314
Query: 424 RRICKAEGSGTGPEKREEAE 443
R+ + E++ E E
Sbjct: 315 RKRERERERERERERQRETE 334
Score = 66.6 bits (161), Expect = 4e-11
Identities = 61/238 (25%), Positives = 106/238 (44%), Gaps = 19/238 (7%)
Query: 189 KNRKLEKQRIREEKREERRRRELEKKRL--REEEKRRRREEERCKKKETDKQKKIAEKEV 246
+ R+ +++R R+ K E R ++ E++R RE E+ + RE ER + ++ D+++K E++
Sbjct: 224 RKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQT 283
Query: 247 RIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHS 306
K ++ E+ E TE+ +ER E + + + R E E +ET
Sbjct: 284 DRKRQRRTERDRE--TERKRERQRERERERERNRKRE-----RERERERERERQRETERD 336
Query: 307 GSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKK 366
+ R +R E + E R +GRR +A E ER R R + +DR +
Sbjct: 337 REKERERKRKRQTEMDRERNRQTGREGRR-QAERERERERERDRQSAREREERERDRDRD 395
Query: 367 GSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPALQLYDPGARFRARECGGNR 424
++ ER R D K+R KDR + + + G R R ++ G R
Sbjct: 396 RQKE-------RERQTEKDR-DGQRETEKQREREKDRESERGRERG-REREKQKGRER 444
Score = 64.3 bits (155), Expect = 2e-10
Identities = 62/277 (22%), Positives = 114/277 (41%), Gaps = 34/277 (12%)
Query: 140 KDPEYKKFLETYCVEEEKTSANP----ETLLGEMEAKTRELIARRTTPLLEYIKNRKLEK 195
+D E ++ +T + +T N E E + RE + + R E+
Sbjct: 153 RDAEKERERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRER 212
Query: 196 QRIREEKREERRRRELEKKRLR----EEEKRRRREEERCKKKETDKQKKIAEKEVRIKLL 251
+R RE + E R+R+ +++R R E E+ ++ E ER ++ET++ K+ + R +
Sbjct: 213 ERERETETETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDR 272
Query: 252 KKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKE 311
+ +K E T++ ++R E D R E E +E
Sbjct: 273 DRRQKERERQTDRKRQRRTERD-----------------RETERKRERQRERERERERNR 315
Query: 312 HRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDS 371
R+ ER +E+E E QR + R R + R++E ++ + G++ ++ ++
Sbjct: 316 KRERERERERERERQR----ETERDREKERERKRKRQTEMDRERNRQTGREGRRQAERER 371
Query: 372 GAPGE-----AMERLGRAQRCDDSPAPRKERLANKDR 403
E A ER R + D +ER KDR
Sbjct: 372 ERERERDRQSAREREERERDRDRDRQKERERQTEKDR 408
>gi|29568103 U1 small nuclear ribonucleoprotein 70 kDa [Homo
sapiens]
Length = 437
Score = 72.4 bits (176), Expect = 8e-13
Identities = 59/188 (31%), Positives = 87/188 (46%), Gaps = 29/188 (15%)
Query: 189 KNRKLEKQRIREEKREERRRRELEKKRLR----EEEKRRRREEERCKKKETDKQKKIAEK 244
+ + E+ R R+++RE RR R +++R +EE+RR R ER K K+ D++++ +
Sbjct: 238 ERERRERSRERDKERERRRSRSRDRRRRSRSRDKEERRRSR--ERSKDKDRDRKRRSSRS 295
Query: 245 EVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEE----- 299
R + + +ER EE+ GGG + P A P +G E
Sbjct: 296 RERAR--------------RERERKEELRGGGG--DMAEPSEAGDAPPDDGPPGELGPDG 339
Query: 300 PQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGP 359
P G D++ R+ RS E E +R D R R H ER S R DE R G G
Sbjct: 340 PDGPEEKGRDRD-RERRRSHRSERERRRDRDRDRDRDREHKRGERGSERGRDEAR-GGGG 397
Query: 360 GQDRGKKG 367
GQD G +G
Sbjct: 398 GQDNGLEG 405
Score = 32.3 bits (72), Expect = 0.89
Identities = 91/404 (22%), Positives = 134/404 (33%), Gaps = 91/404 (22%)
Query: 118 FRNPDDILLFRDRFDGYIFLD--SKDPEYKKFLETYC--------VEEEKTSANP---ET 164
F P+ + LF R D +L K P K + YC E+ + + P ET
Sbjct: 4 FLPPNLLALFAPR-DPIPYLPPLEKLPHEKHHNQPYCGIAPYIREFEDPRDAPPPTRAET 62
Query: 165 LLGEMEAKTRELIARRTTPLLEYIKN--------------RKLEKQRIREEKREERRRRE 210
ME K RE I RR + +K + L R+ + E + RRE
Sbjct: 63 REERMERKRREKIERRQQEVETELKMWDPHNDPNAQGDAFKTLFVARVNYDTTESKLRRE 122
Query: 211 LEK----KRLREEEKRR------------RREEERCKKKETDKQKKIAEKEVRIKLLKKP 254
E KR+ +R E + + KKI + V + +
Sbjct: 123 FEVYGPIKRIHMVYSKRSGKPRGYAFIEYEHERDMHSAYKHADGKKIDGRRVLVDV---- 178
Query: 255 EKGEEPTTEKPKERGEEID---TGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKE 311
E+G +P+ G + GG G +R E P D+E
Sbjct: 179 ERGRTVKGWRPRRLGGGLGGTRRGGADVNIRHSGRDDTSRYDERPGPSPLPHRDRDRDRE 238
Query: 312 HRDVERSQEQESEAQRYH---------------------------VDDGRRHRAHHEPER 344
ERS+E++ E +R D R+ R+ ER
Sbjct: 239 RERRERSRERDKERERRRSRSRDRRRRSRSRDKEERRRSRERSKDKDRDRKRRSSRSRER 298
Query: 345 LSRRSE--DEQRWGKGPGQDRGKKGS--QDSGAPGE-------AMERLGRAQRCDDSPAP 393
R E +E R G G + + G D G PGE E GR + + +
Sbjct: 299 ARRERERKEELRGGGGDMAEPSEAGDAPPDDGPPGELGPDGPDGPEEKGRDRDRERRRSH 358
Query: 394 RKERLANKDRPALQLYDPGARFRARECGGNRRICKAEGSGTGPE 437
R ER +DR + D + E G R +A G G G +
Sbjct: 359 RSERERRRDRDRDR--DRDREHKRGERGSERGRDEARGGGGGQD 400
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 70.5 bits (171), Expect = 3e-12
Identities = 65/240 (27%), Positives = 107/240 (44%), Gaps = 30/240 (12%)
Query: 167 GEMEAK-TRELIARRTTPLLEYIKNRKLEKQRIREEKREER---RRRELEKKRLREEEKR 222
GE + + RE R ++P+ +N +LE+ REE+R +R RR E ++R RE E+
Sbjct: 627 GERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERD 686
Query: 223 RRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESC 282
R RE ER ++++ +++K E+E+ + E+ E E+ KER E D
Sbjct: 687 RERERERERERDREREK---EREL------ERERAREREREREKERDRERDRDRDHDRE- 736
Query: 283 APGAVVKARPMEGSLEEPQETSHSGSDKE-HRDVERSQEQESEAQRYHVDDGRRHRAHH- 340
+ R E E+ +E ++E R+ ER +E+E E +R D R R
Sbjct: 737 ------RERERERDREKEREREREERERERERERERERERERERERARERDKERERQRDW 790
Query: 341 ------EPERLSRRSEDEQRWGKGPGQD--RGKKGSQDSGAPGEAMERLGRAQRCDDSPA 392
+R +R E + G D + KK ++ G+P R + DS A
Sbjct: 791 EDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDA 850
Score = 67.8 bits (164), Expect = 2e-11
Identities = 56/246 (22%), Positives = 111/246 (45%), Gaps = 15/246 (6%)
Query: 189 KNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQK--KIAEKEV 246
K R+LE++R RE +RE + R+ E+ R R+ ++ R RE ER ++KE ++++ + E+E
Sbjct: 703 KERELERERAREREREREKERDRERDRDRDHDRERERERERDREKEREREREERERERER 762
Query: 247 RIKLLKKPEKGEEPTTEKPKER-----GEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQ 301
+ ++ E+ E E+ KER E+ D G + P +G E
Sbjct: 763 ERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPRDGHDERKS 822
Query: 302 ETSH--SGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGP 359
+ + GS + +R +E ++ Y+ D + + H ++ R E
Sbjct: 823 KKRYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNEK-HRLLSQVVRPQESRSLSPSHL 881
Query: 360 GQDRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPALQLYDPGARFRARE 419
+DR + ++ P ER ++R ++ K +K R ++ + +R RA++
Sbjct: 882 TEDRQGRWKEEDRKP----ERKESSRRYEEQELKEKVSSVDKQREQTEILE-SSRMRAQD 936
Query: 420 CGGNRR 425
G+ +
Sbjct: 937 IIGHHQ 942
Score = 35.0 bits (79), Expect = 0.14
Identities = 18/66 (27%), Positives = 39/66 (59%), Gaps = 2/66 (3%)
Query: 186 EYIKNRKLEKQRIREEKREERRRREL--EKKRLREEEKRRRREEERCKKKETDKQKKIAE 243
++ +NR ++ R RE +RE +RR+L E++RL + R R+ +R + E+ + + +
Sbjct: 1330 DWPRNRDRDRLRERERERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKR 1389
Query: 244 KEVRIK 249
E +++
Sbjct: 1390 CEAKLE 1395
Score = 32.7 bits (73), Expect = 0.68
Identities = 44/225 (19%), Positives = 86/225 (38%), Gaps = 21/225 (9%)
Query: 157 KTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRL 216
+ SA+P + ++ R +P+ E K R ++ + R RR + KR
Sbjct: 368 RRSASPYPSHSLSSPQRKQSPPRHRSPMRE--KGRHDHERTSQSHDRRHERREDTRGKRD 425
Query: 217 REEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGG 276
RE + REE ++ ++ + ++E R ++ + T +E + D
Sbjct: 426 RE---KDSREEREYEQDQSSSRDHRDDREPR----DGRDRRDARDTRDRRELRDSRDMRD 478
Query: 277 GKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERS-----QEQESEAQRYHVD 331
++ ++R S +H D+E RD R +E S + + +
Sbjct: 479 SREMRDYSRDTKESRDPRDS--RSTRDAHDYRDREGRDTHRKEDTYPEESRSYGRNHLRE 536
Query: 332 DGRRHRAHHEPERLSRRSEDEQRWGKGPGQ-----DRGKKGSQDS 371
+ R +E SR R G+ G+ ++G +GS+ S
Sbjct: 537 ESSRTEIRNESRNESRSEIRNDRMGRSRGRVPELPEKGSRGSRGS 581
Score = 30.8 bits (68), Expect = 2.6
Identities = 48/239 (20%), Positives = 92/239 (38%), Gaps = 26/239 (10%)
Query: 139 SKDPEYKKFLETYCVEEEKTSANPETLLGEMEAKT-------RELIARRTTPLLEYIKNR 191
S+D E K LE + E+ S + GE T R +RR++P + +
Sbjct: 1232 SRDREKTKSLE---ITGERKSRIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHS 1288
Query: 192 KLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQK---KIAEKEVRI 248
+ R+ + +ER R E +++R RE R+RE +R K+ + + ++ E+E
Sbjct: 1289 RSGSFDSRD-RLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERE--- 1344
Query: 249 KLLKKPEKGEEPTTEKPKER----GEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETS 304
++ E+ + ++ +ER E D + + + + E LE E
Sbjct: 1345 ---RERERDKRRDLDRERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKLEGEHERD 1401
Query: 305 HSGSDKEH--RDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQ 361
+ ++ D ER + Q + + E + +D G G G+
Sbjct: 1402 LESTSRDSLALDKERMDKDLGSVQGFEETNKSERTESLEAGDDESKLDDAHSLGSGAGE 1460
Score = 30.4 bits (67), Expect = 3.4
Identities = 48/230 (20%), Positives = 88/230 (38%), Gaps = 25/230 (10%)
Query: 154 EEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREER----RRR 209
EE + E+ G K I + TP E +N + E R + +
Sbjct: 106 EESSSPVRKESSRGRHREKEDIKITKERTPESEE-ENVEWETNRDDSDNGDINYDYVHEL 164
Query: 210 ELEKKRLREEEKRRRREEERC-KKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKER 268
LE KR + + + + E+E K++E +K+++ + VR KL P +++ PK +
Sbjct: 165 SLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKL--SPSPSLRKSSKSPKRK 222
Query: 269 GEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRY 328
+ K++ K + L + Q S + K+ S
Sbjct: 223 SSPKSSSASKKDR-------KTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIP---- 271
Query: 329 HVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQD----RGKKGSQDSGAP 374
+D + + E ++ R E++ R GK G+D R K+ S +P
Sbjct: 272 --EDIALGKKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSP 319
Score = 30.0 bits (66), Expect = 4.4
Identities = 61/310 (19%), Positives = 113/310 (36%), Gaps = 34/310 (10%)
Query: 111 YSRAYINFRNPDDILLFRDRFDGYIFLDSKDPEYKKFLETYCVEEEKTSANPETLLGEME 170
YSR R+P D RD D Y + +D K+ +TY E N L E
Sbjct: 485 YSRDTKESRDPRDSRSTRDAHD-YRDREGRDTHRKE--DTYPEESRSYGRNH---LREES 538
Query: 171 AKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERC 230
++T R E I+N ++ + R R + E+ R ++ +
Sbjct: 539 SRTEIRNESRNESRSE-IRNDRMGRSRGRVPELPEKGSRGSRGSQIDSHSSNSNYHDSWE 597
Query: 231 KKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKA 290
+ ++ + E++ R ++ + + E+ R E D ++ P + ++
Sbjct: 598 TRSSYPERDRYPERDNR-------DQARDSSFER---RHGERDRRDNRERDQRPSSPIRH 647
Query: 291 RPMEGSLEEPQETSHSGSDK-EHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRS 349
+ LE + D+ + R ER++E++ E +R D R R R
Sbjct: 648 QGRNDELERDERREERRVDRVDDRRDERARERDRERER----DRERERERERERDREREK 703
Query: 350 EDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPALQLY 409
E E + ++R ++ +D R + D +ER +DR +
Sbjct: 704 ERELERERAREREREREKERD------------RERDRDRDHDRERERERERDREKERER 751
Query: 410 DPGARFRARE 419
+ R R RE
Sbjct: 752 EREERERERE 761
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 67.8 bits (164), Expect = 2e-11
Identities = 67/238 (28%), Positives = 106/238 (44%), Gaps = 42/238 (17%)
Query: 188 IKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVR 247
I+ RK K+ E+++ERR RE KR RE EK R+R ER KK++ ++KK + +
Sbjct: 45 IETRKEGKKERESERKKERRERE---KRKREREKERKR--ERGKKEKKGERKKEERERKK 99
Query: 248 IKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSG 307
+ K+ ++GEE K KE+ E T +E + R E EE +E
Sbjct: 100 RRREKENKEGEEKEKRKKKEKKERGRTSKEGKE--------RERKEERKREERKERERK- 150
Query: 308 SDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKG 367
KE R+ ER +++ + +R V G + E ER R+ + R ++R K+
Sbjct: 151 --KEEREKERERKERKKRERKQV--GEKEEERKEKERKERKKRERNR------KERKKE- 199
Query: 368 SQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPALQLYDPGARFRARECGGNRR 425
ER R +R +KER ++R + D +R +E G R
Sbjct: 200 ----------RERKERRER-------KKERKKKEERKKERQKDRQTNWREKERGKRER 240
Score = 61.6 bits (148), Expect = 1e-09
Identities = 48/203 (23%), Positives = 100/203 (49%), Gaps = 18/203 (8%)
Query: 167 GEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRRE 226
G+ E ++ RR + + ++ +++R ++EK+ ER++ E E+K+ R E++ + E
Sbjct: 51 GKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERKKRRREKENKEGE 110
Query: 227 EERCKKKETDKQKKIAEKEVRIKLLKKPEKGEE--PTTEKPKERGEEIDTGGGKQESCAP 284
E+ +KK+ K++ KE + + K+ K EE K +ER +E + K+
Sbjct: 111 EKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKERERKERKK----- 165
Query: 285 GAVVKARPMEGSLEEPQETSHSGSDKEHRDVERS-QEQESEAQRYHVDDGRRHRAHHEPE 343
+ R G EE ++ KE + ER+ +E++ E +R + ++ R E
Sbjct: 166 ----RERKQVGEKEEERKEKER---KERKKRERNRKERKKERERKERRERKKERKKKEER 218
Query: 344 RLSRRSEDEQRWGKGPGQDRGKK 366
+ R+ + + W + ++RGK+
Sbjct: 219 KKERQKDRQTNWRE---KERGKR 238
Score = 53.5 bits (127), Expect = 4e-07
Identities = 29/92 (31%), Positives = 49/92 (53%)
Query: 154 EEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEK 213
E ++ E E E K R+ R+ E + K K+R + E+ + R++E E+
Sbjct: 143 ERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERER 202
Query: 214 KRLREEEKRRRREEERCKKKETDKQKKIAEKE 245
K RE +K R+++EER K+++ D+Q EKE
Sbjct: 203 KERRERKKERKKKEERKKERQKDRQTNWREKE 234
Score = 43.5 bits (101), Expect = 4e-04
Identities = 23/74 (31%), Positives = 46/74 (62%), Gaps = 2/74 (2%)
Query: 194 EKQRIREEKRE-ERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLK 252
EK+ R+EK ER++RE +K ++E +R+ R E + ++K+ +++KK +K+ + +
Sbjct: 173 EKEEERKEKERKERKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWRE 232
Query: 253 KPEKGEEPTTEKPK 266
K E+G+ E+ K
Sbjct: 233 K-ERGKRERKERKK 245
Score = 42.4 bits (98), Expect = 9e-04
Identities = 30/109 (27%), Positives = 52/109 (47%), Gaps = 7/109 (6%)
Query: 138 DSKDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQR 197
+ + E +K E E EK E E + + R+ E K + K+R
Sbjct: 137 EERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKER 196
Query: 198 IREEKREERRRRELEKKRLREEEKRRR-------REEERCKKKETDKQK 239
+E +R+ERR R+ E+K+ E +K R+ RE+ER K++ +++K
Sbjct: 197 KKERERKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKERKK 245
>gi|239747174 PREDICTED: hypothetical protein XP_002343931, partial
[Homo sapiens]
Length = 213
Score = 66.6 bits (161), Expect = 4e-11
Identities = 47/168 (27%), Positives = 85/168 (50%), Gaps = 5/168 (2%)
Query: 189 KNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQK-KIAEKEVR 247
++ + ++QR RE RE R RE EK+ RE E++R RE +R +++ET++++ K E +
Sbjct: 42 RHSERDRQRDRERNRERDRDREREKQTDREGERQRERERDRDRQRETERERDKERETDRH 101
Query: 248 IKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHS- 306
+ ++ +K +E E+ ++R E G++ R E E +ET
Sbjct: 102 TETDRERQKQKEREMERVRDREREKQKEMGRERQTDRET---DRERERQAERERETGRER 158
Query: 307 GSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQR 354
++ HR+ ER +++E E +R + R E +R + R D QR
Sbjct: 159 KTEDRHRERERERKRERERKRETKERERHTDMERERQRETDRKRDRQR 206
Score = 58.2 bits (139), Expect = 2e-08
Identities = 37/153 (24%), Positives = 76/153 (49%), Gaps = 4/153 (2%)
Query: 189 KNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRI 248
++R+ EKQ RE +R+ R R+ +++R E E+ + RE +R + + ++QK+ + R+
Sbjct: 60 RDREREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKEREMERV 119
Query: 249 K---LLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSH 305
+ K+ E G E T++ +R E ++ + R E + +E
Sbjct: 120 RDREREKQKEMGRERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKR 179
Query: 306 SGSDKE-HRDVERSQEQESEAQRYHVDDGRRHR 337
++E H D+ER +++E++ +R + R R
Sbjct: 180 ETKERERHTDMERERQRETDRKRDRQRESERER 212
Score = 47.4 bits (111), Expect = 3e-05
Identities = 43/209 (20%), Positives = 91/209 (43%), Gaps = 17/209 (8%)
Query: 201 EKREERRRRELEKKRL-REEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEE 259
E + E R E + + R+ E+RR + ER + KE+ + + +E++ ++ ++
Sbjct: 2 ESKTEGRHTHTETETMDRQRERRRETDRERDRAKESKTEDRHSERD------RQRDRERN 55
Query: 260 PTTEKPKERGEEIDTGGGKQ-----ESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRD 314
++ +ER ++ D G +Q + + R E + ET ++ R+
Sbjct: 56 RERDRDREREKQTDREGERQRERERDRDRQRETERERDKERETDRHTETDRERQKQKERE 115
Query: 315 VERSQEQESEAQRYHVDDGRRHRAHHEPER-LSRRSEDEQRWGK-GPGQDRGKKGSQDSG 372
+ER +++E E Q+ + GR + E +R R++E E+ G+ +DR ++ ++
Sbjct: 116 MERVRDREREKQK---EMGRERQTDRETDRERERQAERERETGRERKTEDRHRERERERK 172
Query: 373 APGEAMERLGRAQRCDDSPAPRKERLANK 401
E +R D R+ K
Sbjct: 173 RERERKRETKERERHTDMERERQRETDRK 201
Score = 47.0 bits (110), Expect = 3e-05
Identities = 36/143 (25%), Positives = 71/143 (49%), Gaps = 18/143 (12%)
Query: 140 KDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQ--- 196
+D + ++ E +E +T + ET + K RE+ E +++R+ EKQ
Sbjct: 80 RDRDRQRETERERDKERETDRHTETDRERQKQKEREM---------ERVRDREREKQKEM 130
Query: 197 -RIREEKREERRRRELEKKRLREEEKRRR-----REEERCKKKETDKQKKIAEKEVRIKL 250
R R+ RE R RE + +R RE + R+ RE ER +K+E +++++ E+E +
Sbjct: 131 GRERQTDRETDRERERQAERERETGRERKTEDRHRERERERKRERERKRETKERERHTDM 190
Query: 251 LKKPEKGEEPTTEKPKERGEEID 273
++ ++ + ++ +E E D
Sbjct: 191 ERERQRETDRKRDRQRESERERD 213
Score = 46.2 bits (108), Expect = 6e-05
Identities = 30/106 (28%), Positives = 57/106 (53%), Gaps = 5/106 (4%)
Query: 179 RRTTPLLEYIKNRKLEKQRIREEKREER----RRRELEKKRLREEEKRRRREEERCKKKE 234
R T E K ++ E +R+R+ +RE++ R R+ +++ RE E++ RE E ++++
Sbjct: 100 RHTETDRERQKQKEREMERVRDREREKQKEMGRERQTDRETDRERERQAERERETGRERK 159
Query: 235 TDKQKKIAEKE-VRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQ 279
T+ + + E+E R + K+ K E T+ +ER E D +Q
Sbjct: 160 TEDRHRERERERKRERERKRETKERERHTDMERERQRETDRKRDRQ 205
>gi|4503509 eukaryotic translation initiation factor 3, subunit 10
theta, 150/170kDa [Homo sapiens]
Length = 1382
Score = 65.5 bits (158), Expect = 9e-11
Identities = 88/354 (24%), Positives = 157/354 (44%), Gaps = 59/354 (16%)
Query: 81 KEQLEEQLRPLPAH-DYFEFFAADLSLYPHLYSRAYINFRNPDDILLFRDRFDGYIFLDS 139
K++L+E+L+ DYFE A L P L AY R D +D
Sbjct: 681 KKELQERLKNQEKKIDYFER-AKRLEEIP-LIKSAYEEQRIKD--------------MDL 724
Query: 140 KDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEK--QR 197
+ + ++ + T +E EK + + +E R+L R + + KL++ +R
Sbjct: 725 WEQQEEERITTMQLEREKALEHKNRMSRMLE--DRDLFVMRLKAARQSVYEEKLKQFEER 782
Query: 198 IREEKR---EERRRRELEKKRL-----REEEKRRRREEERCKKKETDKQKKIAEKEVRIK 249
+ EE+ EER+R+ E++R+ +EEE++RR EE+ K++E ++ + A++E ++
Sbjct: 783 LAEERHNRLEERKRQRKEERRITYYREKEEEEQRRAEEQMLKEREERERAERAKREEELR 842
Query: 250 LLKKPEKGEEPTTEKPKERGEEIDTGGGKQES---CAPGAVVKA------RPMEGSL--- 297
++ K E K ++R EI+ ++E ++ + R EG+
Sbjct: 843 EYQERVKKLEEVERKKRQRELEIEERERRREEERRLGDSSLSRKDSRWGDRDSEGTWRKG 902
Query: 298 -EEPQETSHSGSDK-----EHRDVERSQEQESE-AQRYHVDDGRRHRAHHEPERLSRRSE 350
E E +K E RD +RS ++ E +R D+ R + +R+ RR
Sbjct: 903 PEADSEWRRGPPEKEWRRGEGRDEDRSHRRDEERPRRLGDDEDREPSLRPDDDRVPRRGM 962
Query: 351 DEQRW-GKGPGQDRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDR 403
D+ R +GP +DR + D P + DD PR R+A++DR
Sbjct: 963 DDDRGPRRGPEEDRFSRRGADDDRPS--------WRNTDDDRPPR--RIADEDR 1006
Score = 51.6 bits (122), Expect = 1e-06
Identities = 42/123 (34%), Positives = 66/123 (53%), Gaps = 6/123 (4%)
Query: 154 EEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKRE-ERRRRELE 212
+EE+ L + + ++ARR T +E K R LE I+ EK E E+R EL+
Sbjct: 546 KEEQHQLAVTAYLKNSRKEHQRILARRQT--IEERKER-LESLNIQREKEELEQREAELQ 602
Query: 213 KKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKL--LKKPEKGEEPTTEKPKERGE 270
K R EEE+ R+ +ER K++ + ++I +K VR +L +KK E G + + E E
Sbjct: 603 KVRKAEEERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLE 662
Query: 271 EID 273
E+D
Sbjct: 663 ELD 665
Score = 37.4 bits (85), Expect = 0.028
Identities = 75/350 (21%), Positives = 123/350 (35%), Gaps = 108/350 (30%)
Query: 154 EEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKN-RKLE----KQRIRE---EKREE 205
EEE+ E +L E E + R A+R L EY + +KLE K+R RE E+RE
Sbjct: 811 EEEEQRRAEEQMLKEREERERAERAKREEELREYQERVKKLEEVERKKRQRELEIEERER 870
Query: 206 RRRRE-------LEKKRLR-------------------------EEEKRRR--REEERCK 231
RR E L +K R E+E RR R+E+R
Sbjct: 871 RREEERRLGDSSLSRKDSRWGDRDSEGTWRKGPEADSEWRRGPPEKEWRRGEGRDEDRSH 930
Query: 232 KKETDKQKKIAEKEVRIKLLKK---------------PEKGEEPTT-------------- 262
+++ ++ +++ + E R L+ P +G E
Sbjct: 931 RRDEERPRRLGDDEDREPSLRPDDDRVPRRGMDDDRGPRRGPEEDRFSRRGADDDRPSWR 990
Query: 263 ------------------------EKPKERGEEIDTGGGK--QESCAP--GAVVKARPME 294
++P RG + D G + E P G P
Sbjct: 991 NTDDDRPPRRIADEDRGNWRHADDDRPPRRGLDEDRGSWRTADEDRGPRRGMDDDRGPRR 1050
Query: 295 GSLEEPQETSHSGSD----KEHRDVERSQEQ---ESEAQRYHVDDGRRHRAHHEPERLSR 347
G ++ + + + D + D +R + + R +DD R R + +R R
Sbjct: 1051 GGADDERSSWRNADDDRGPRRGLDDDRGPRRGMDDDRGPRRGMDDDRGPRRGMDDDRGPR 1110
Query: 348 RSEDEQR--WGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRK 395
R D+ R W ++G++D P M+ ++R DD PR+
Sbjct: 1111 RGLDDDRGPWRNADDDRIPRRGAEDDRGPWRNMDDDRLSRRADDDRFPRR 1160
Score = 36.6 bits (83), Expect = 0.047
Identities = 50/226 (22%), Positives = 99/226 (43%), Gaps = 36/226 (15%)
Query: 136 FLDSKDPEYKKFL-ETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLE 194
+L + E+++ L +EE K + E E EL R E K RK E
Sbjct: 557 YLKNSRKEHQRILARRQTIEERKERLESLNIQREKE----ELEQREA----ELQKVRKAE 608
Query: 195 KQRIREEKREERRRR------ELEKKRLREEEKRRRREE---ERCKKKETDKQKKIAEKE 245
++R+R+E +E + R +++KK +RE ++ ++ E + K + + +++
Sbjct: 609 EERLRQEAKEREKERILQEHEQIKKKTVRERLEQIKKTELGAKAFKDIDIEDLEELDPDF 668
Query: 246 VRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSH 305
+ K +++ EK ++ E+ K + ++ID +A+ LEE
Sbjct: 669 IMAKQVEQLEKEKKELQERLKNQEKKID------------YFERAK----RLEEIPLIKS 712
Query: 306 SGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSED 351
+ ++ +D++ ++QE E R R +A R+SR ED
Sbjct: 713 AYEEQRIKDMDLWEQQEEE--RITTMQLEREKALEHKNRMSRMLED 756
Score = 33.9 bits (76), Expect = 0.30
Identities = 36/182 (19%), Positives = 68/182 (37%), Gaps = 26/182 (14%)
Query: 189 KNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREE---------------ERCKKK 233
K R + Q E ++ R R+ E+ RE+ RR R+E + ++
Sbjct: 1207 KERDRDNQDREENDKDPERERDRERDVDREDRFRRPRDEGGWRRGPAEESSSWRDSSRRD 1266
Query: 234 ETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPM 293
+ D+ + E++ R L ++ + ++ P R E + ++ V+ R
Sbjct: 1267 DRDRDDRRRERDDRRDLRERRDLRDDRDRRGPPLRSEREEVSSWRRADDRKDDRVEERDP 1326
Query: 294 EGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQ 353
+ P + S RD +R +E E E + + R E R ++ DE
Sbjct: 1327 PRRVPPP-----ALSRDRERDRDREREGEKEKASWRAEKDR------ESLRRTKNETDED 1375
Query: 354 RW 355
W
Sbjct: 1376 GW 1377
Score = 33.1 bits (74), Expect = 0.52
Identities = 49/212 (23%), Positives = 81/212 (38%), Gaps = 31/212 (14%)
Query: 203 REERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTT 262
RE+ + RE RE RE +R K+++ D Q + E ++P
Sbjct: 1179 REKEKAREESWGPPRESRPSEEREWDREKERDRDNQ-------------DREENDKDPER 1225
Query: 263 EKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQE 322
E+ +ER ++D + G + P E S + D++ R ER ++
Sbjct: 1226 ERDRER--DVDREDRFRRPRDEGG-WRRGPAEESSSWRDSSRRDDRDRDDRRRERDDRRD 1282
Query: 323 SEAQRYHVDDGRRH----RAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAM 378
+R DD R R+ E RR++D + DR ++ P A+
Sbjct: 1283 LRERRDLRDDRDRRGPPLRSEREEVSSWRRADDRK-------DDRVEERDPPRRVPPPAL 1335
Query: 379 ERLGRAQRCDDSPAPRKERL---ANKDRPALQ 407
R R + D KE+ A KDR +L+
Sbjct: 1336 SR-DRERDRDREREGEKEKASWRAEKDRESLR 1366
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 65.1 bits (157), Expect = 1e-10
Identities = 71/285 (24%), Positives = 122/285 (42%), Gaps = 46/285 (16%)
Query: 163 ETLLGEMEAKTRELIARRTTPLLEYIKNRK-LEKQRIRE------EKREERRRRELEKKR 215
E L E E R+L+A R + + + R+ LE+Q+ RE ++RE+RRR + EK+R
Sbjct: 378 EQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRR 437
Query: 216 LREEEKRRRREEERCKKKETDK---------QKKIAEKEVRIKLLKKPEKGEEPT----- 261
L E E+RR+ EEER + +E + ++++ E++ +++L++ E+
Sbjct: 438 LEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLHDH 497
Query: 262 -------TEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRD 314
+++P +E K AP P + + E P T+ RD
Sbjct: 498 RRPHPQHSQQPPPPQQE----RSKPSFHAPEPKAHYEPADRAREVPVRTTSRSPVLSRRD 553
Query: 315 --VERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSED-EQRWGKGPGQDRGKKGSQDS 371
++ S +Q S+A + R + EP L R E R G G GSQ
Sbjct: 554 SPLQGSGQQNSQAGQ------RNSTSSIEPRLLWERVEKLVPRPGSGSSSGSSNSGSQPG 607
Query: 372 GAPGEAME-----RLGRAQRCDDSPAPRKERLANKDRPALQLYDP 411
PG R+ + + + SP+ R E K +++ P
Sbjct: 608 SHPGSQSGSGERFRVRSSSKSEGSPSQRLENAVKKPEDKKEVFRP 652
Score = 48.5 bits (114), Expect = 1e-05
Identities = 67/291 (23%), Positives = 119/291 (40%), Gaps = 30/291 (10%)
Query: 168 EMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREE 227
+ E K R RR L E + E +R +R++R ++ E++R EE++RR RE
Sbjct: 360 QQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREA 419
Query: 228 ERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEP--TTEKPKERGEEIDTGGGKQESCAPG 285
R ++E +++++ E++ R++ L++ K EE E+ K R E +QE
Sbjct: 420 RR--QQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVER------EQEYIRRQ 471
Query: 286 AVVKARPMEGSLEEPQET------SHSGSDKEHRDVERSQEQESEAQRYHVDDGRRH--- 336
+ R +E ++ + H +H +QE +H + + H
Sbjct: 472 LEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQPPPPQQERSKPSFHAPEPKAHYEP 531
Query: 337 --RAHHEPERLSRRSEDEQRWG---KGPGQDRGKKGSQDSGAPGEAMERLGRAQRCDDSP 391
RA P R + RS R +G GQ + G ++S + E R ++ P
Sbjct: 532 ADRAREVPVRTTSRSPVLSRRDSPLQGSGQQNSQAGQRNSTSSIEPRLLWERVEKL--VP 589
Query: 392 APRKERLANKDRPALQLYDPGARFRARECGGNR-RICKAEGSGTGPEKREE 441
P + Q PG+ ++ G R R+ + S P +R E
Sbjct: 590 RPGSGSSSGSSNSGSQ---PGSHPGSQSGSGERFRVRSSSKSEGSPSQRLE 637
Score = 45.1 bits (105), Expect = 1e-04
Identities = 50/222 (22%), Positives = 92/222 (41%), Gaps = 28/222 (12%)
Query: 193 LEKQRIREEKREERRRRELEKKRLREEEKRRRREE-------ERCKKKETDKQ--KKIAE 243
L + +R ++ + R L +++L +E++ R +EE ER K+ E K+ +++ E
Sbjct: 352 LRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEE 411
Query: 244 KEVRIKLLKKPEKGEEPTTE-KPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQE 302
++ R + ++ ++ E+ E + K R EE++ ++E K R +E QE
Sbjct: 412 QQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRR-----VEREQE 466
Query: 303 TSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQD 362
++E R +E Q+Q + Q + D RR H + P Q
Sbjct: 467 YIRRQLEEEQRHLEVLQQQLLQEQAMLLHDHRRPHPQHSQQ-------------PPPPQQ 513
Query: 363 RGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRP 404
K S + P E RA+ R L+ +D P
Sbjct: 514 ERSKPSFHAPEPKAHYEPADRAREVPVRTTSRSPVLSRRDSP 555
>gi|169167715 PREDICTED: hypothetical protein [Homo sapiens]
Length = 285
Score = 64.3 bits (155), Expect = 2e-10
Identities = 43/172 (25%), Positives = 85/172 (49%), Gaps = 9/172 (5%)
Query: 189 KNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRI 248
K R EK R E+ R+ +R+R+ E++R R+ +++R R +R ++ ET++Q+ E+E +
Sbjct: 74 KERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDRETETERQE---ERERQR 130
Query: 249 KLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGS 308
++ ++ + E ++ EI+T + G + R E ++ +ET
Sbjct: 131 DRKREKDRERQRQREIGIDKDREIETEKDRDREREMGETERYRDRERERQKQRETRRDRD 190
Query: 309 -----DKEHRDVERSQEQESEAQRYHV-DDGRRHRAHHEPERLSRRSEDEQR 354
+KE R+ +R +++E E RY + GR + ER + D Q+
Sbjct: 191 RERQREKEDRERDRDRQKEREKDRYRERETGRDRDKERDRERQREKDRDRQK 242
Score = 63.9 bits (154), Expect = 3e-10
Identities = 58/244 (23%), Positives = 117/244 (47%), Gaps = 27/244 (11%)
Query: 191 RKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKK-----IAEKE 245
R+ E+QR RE +R+ + R EK R E+++ R+R+ +R +++ D+ +K ++E
Sbjct: 58 RERERQRERERQRKRAKERHREKDREIEKDRDRQRKRDRERQRWRDRDRKRERWGDRDRE 117
Query: 246 VRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSH 305
+ ++ E+ + EK +ER + + G + K R +E + +E
Sbjct: 118 TETERQEERERQRDRKREKDRERQRQREIG-----------IDKDREIETEKDRDRE-RE 165
Query: 306 SGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRW-GKGPGQDRG 364
G + +RD ER ++++ E +R + +R + E +R ++ ++ R+ + G+DR
Sbjct: 166 MGETERYRDRERERQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRDRD 225
Query: 365 KKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKD----RPALQLYDPGARFRAREC 420
K+ ++ + + R + D P + + D R + + D G R RARE
Sbjct: 226 KERDRER----QREKDRDRQKAIDCVPGRWEVTVMAVDCVPGRWEVTVGD-GRRLRAREV 280
Query: 421 GGNR 424
GG+R
Sbjct: 281 GGDR 284
Score = 55.5 bits (132), Expect = 1e-07
Identities = 31/100 (31%), Positives = 55/100 (55%), Gaps = 3/100 (3%)
Query: 189 KNRKLEKQRIREEKRE---ERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKE 245
K+R++E ++ R+ +RE R R+ E++R ++ E RR R+ ER ++KE ++ + +KE
Sbjct: 150 KDREIETEKDRDREREMGETERYRDRERERQKQRETRRDRDRERQREKEDRERDRDRQKE 209
Query: 246 VRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPG 285
++ E G + E+ +ER E D K C PG
Sbjct: 210 REKDRYRERETGRDRDKERDRERQREKDRDRQKAIDCVPG 249
Score = 47.8 bits (112), Expect = 2e-05
Identities = 30/107 (28%), Positives = 56/107 (52%), Gaps = 20/107 (18%)
Query: 186 EYIKNRKLEKQRIREEKREERRRRELEKK-RLREEEKRRRREEERCKKKETDKQKKIAEK 244
E ++R+ E+Q+ RE +R+ R R+ EK+ R R+ ++++ RE++R +++ET +
Sbjct: 170 ERYRDRERERQKQRETRRDRDRERQREKEDRERDRDRQKEREKDRYRERETGRD------ 223
Query: 245 EVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQE------SCAPG 285
+ E+ E EK ++R + ID G+ E C PG
Sbjct: 224 -------RDKERDRERQREKDRDRQKAIDCVPGRWEVTVMAVDCVPG 263
>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
containing B [Homo sapiens]
Length = 546
Score = 64.3 bits (155), Expect = 2e-10
Identities = 49/216 (22%), Positives = 102/216 (47%), Gaps = 11/216 (5%)
Query: 191 RKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKL 250
R+ E+QR+ E +E + R + R E+RR R ER + + + +K ++ +
Sbjct: 297 REKERQRLEREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDRER 356
Query: 251 LKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDK 310
K+ E+G + KERG E + + + K + G +EE ++ D+
Sbjct: 357 EKENERGRRRDRDYDKERGNEREKERERSRERS-----KEQRSRGEVEE-KKHKEDKDDR 410
Query: 311 EHRDVERSQEQESEAQRYHVDDGR---RHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKG 367
HRD +R ++E + R + + R R+ + +R RS+++ K +++ K
Sbjct: 411 RHRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKR 470
Query: 368 SQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDR 403
S+ SG+ G + + ++++ + SP+ K R ++ +
Sbjct: 471 SR-SGSQGRT-DSVEKSKKREHSPSKEKSRKRSRSK 504
Score = 52.4 bits (124), Expect = 8e-07
Identities = 46/167 (27%), Positives = 77/167 (46%), Gaps = 26/167 (15%)
Query: 191 RKLEKQRIREEKREERRRRELEKKRLREE-EKRRRREEERCKKKE--------------T 235
R+ E++R RE +E+R R E+E+K+ +E+ + RR R+++R KKE +
Sbjct: 378 REKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKKHSRSRSRERKHRS 437
Query: 236 DKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGG------GKQESCAPGAVVK 289
+ + A K R + +K K + + EK +R G K+ +P K
Sbjct: 438 RSRSRNAGKRSRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVEKSKKREHSPSKE-K 496
Query: 290 ARPMEGSLEEPQETSHSGS----DKEHRDVERSQEQESEAQRYHVDD 332
+R S E + HS S DK R +S EQES+ +++ D
Sbjct: 497 SRKRSRSKERSHKRDHSDSKDQSDKHDRRRSQSIEQESQEKQHKNKD 543
Score = 50.1 bits (118), Expect = 4e-06
Identities = 56/223 (25%), Positives = 94/223 (42%), Gaps = 37/223 (16%)
Query: 168 EMEAKTRELIARRTTPL---LEYIKNRKLEKQRIR-----------------EEKRE--E 205
E EAK RE RR+ + LE ++R E+ R R E++ E
Sbjct: 305 EREAKEREKERRRSRSIDRGLERRRSRSRERHRSRSRSRDRKGDRRDRDREREKENERGR 364
Query: 206 RRRRELEKKRLREEEKRRRREEERCKKK----ETDKQKKIAEKEVR-----IKLLKKPEK 256
RR R+ +K+R E EK R R ER K++ E +++K +K+ R + KK +K
Sbjct: 365 RRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDKDDRRHRDDKRDSKKEKK 424
Query: 257 GEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVE 316
+ + K R GK+ S + ++ S E+ + S SGS VE
Sbjct: 425 HSRSRSRERKHRSRSRSRNAGKR-SRSRSKEKSSKHKNESKEKSNKRSRSGSQGRTDSVE 483
Query: 317 RSQEQE-----SEAQRYHVDDGRRHRAHHEPERLSRRSEDEQR 354
+S+++E ++++ R H+ H + D +R
Sbjct: 484 KSKKREHSPSKEKSRKRSRSKERSHKRDHSDSKDQSDKHDRRR 526
>gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]
Length = 290
Score = 63.9 bits (154), Expect = 3e-10
Identities = 49/183 (26%), Positives = 88/183 (48%), Gaps = 13/183 (7%)
Query: 189 KNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKI------- 241
K ++ + R RE++ E R RE EK++ RE E+ R RE ER + +E +++++
Sbjct: 105 KEKETNRNRDREKQTEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQ 164
Query: 242 AEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQ---ESCAPGAVVKARPMEGSLE 298
E E + ++ EK +E TE+ ++R + + +Q E R E E
Sbjct: 165 RETETERERDREREKQKERETERDRDRQRDTEKERERQTDRERDRQRKTQTERQRETDRE 224
Query: 299 EPQETSHSGSDKEHRD--VERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQR-W 355
+ET + RD ER +E++ + +R R + E ++ +R ED++R W
Sbjct: 225 GERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKERKEKKKEEKRREDKKRKW 284
Query: 356 GKG 358
G+G
Sbjct: 285 GEG 287
Score = 60.5 bits (145), Expect = 3e-09
Identities = 53/209 (25%), Positives = 95/209 (45%), Gaps = 30/209 (14%)
Query: 190 NRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIK 249
+R+ E+ R+RE+ +ER R ++KR RE RRR+E+E + ++ +KQ +I R K
Sbjct: 76 DRQRERDRVREKTEKERDR---DRKRDRE---RRRKEKETNRNRDREKQTEIERDREREK 129
Query: 250 LLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSD 309
+KG E ++ +ER + D + + E E+ ++
Sbjct: 130 -----QKGRERERDRGRERERDRD---------------REKERERQTEKDRDGQRETET 169
Query: 310 KEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQ-DRGKKGS 368
+ RD ER +++E E +R D R+ E ER + R D QR + Q + ++G
Sbjct: 170 ERERDREREKQKERETER---DRDRQRDTEKERERQTDRERDRQRKTQTERQRETDREGE 226
Query: 369 QDSGAPGEAMERLGRAQRCDDSPAPRKER 397
+++ E R + D ++ER
Sbjct: 227 RETDRRRERQRDRDRGKERDRERDRKEER 255
Score = 43.9 bits (102), Expect = 3e-04
Identities = 26/79 (32%), Positives = 46/79 (58%), Gaps = 3/79 (3%)
Query: 168 EMEAKTRELIARRTTPLLEYIKNRKLEKQRIRE---EKREERRRRELEKKRLREEEKRRR 224
+ + KT+ R T E +R+ E+QR R+ E+ ER R+E KK ++E K+ R
Sbjct: 208 DRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKER 267
Query: 225 REEERCKKKETDKQKKIAE 243
+E+++ +K+ DK++K E
Sbjct: 268 KEKKKEEKRREDKKRKWGE 286
Score = 42.7 bits (99), Expect = 7e-04
Identities = 29/91 (31%), Positives = 49/91 (53%), Gaps = 2/91 (2%)
Query: 168 EMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREE 227
E E +T R+ E + E +R + +RE +R R+ K+R RE +++ R++
Sbjct: 198 ERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEERKK 257
Query: 228 ERCKKKETDKQKKIAEKEVRIKLLKKPEKGE 258
ER KKE K++K +KE + + KK + GE
Sbjct: 258 ER--KKERKKERKEKKKEEKRREDKKRKWGE 286
Score = 29.6 bits (65), Expect = 5.7
Identities = 34/135 (25%), Positives = 53/135 (39%), Gaps = 26/135 (19%)
Query: 295 GSLEEPQE----TSHSGSDKEHRDVERS---QEQESEAQRYHVDDGRRHRAHHEPER--- 344
GS E P+ +H +D + R ER ++ E E R D R R E R
Sbjct: 55 GSQESPRSWGLGQAHKDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRD 114
Query: 345 ------LSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGR---AQRCDDSPAPR- 394
+ R E E++ G+ +DRG++ +D E + + QR ++ R
Sbjct: 115 REKQTEIERDREREKQKGRERERDRGRERERDRDREKERERQTEKDRDGQRETETERERD 174
Query: 395 ------KERLANKDR 403
KER +DR
Sbjct: 175 REREKQKERETERDR 189
>gi|239745095 PREDICTED: hypothetical protein LOC645202 [Homo
sapiens]
Length = 570
Score = 62.8 bits (151), Expect = 6e-10
Identities = 59/223 (26%), Positives = 109/223 (48%), Gaps = 22/223 (9%)
Query: 191 RKLEKQRIREEK---REERRRRELEKKRLREE-----EKRRRREEERCKKKETDKQKKIA 242
R+ EK + REEK +EE+ R + EK R +EE E++ RR+EE +KE +K +++
Sbjct: 292 RQEEKIQEREEKIQEQEEKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKE-EKIRELE 350
Query: 243 EK-EVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQ 301
EK + K+ ++ EK +E + +E+ +E + +QE K R E + E +
Sbjct: 351 EKMHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEE-------KIREQEEKIREQE 403
Query: 302 ETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQ 361
E +K E+ EQE E Q R+ E E+ R E++ R + Q
Sbjct: 404 EMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQ 463
Query: 362 DRGKK-GSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDR 403
++ +K G Q+ G+ E+ + Q ++ ++E++ +++
Sbjct: 464 EQEEKMGEQE----GKMCEQEAKMQEQEEKMRRQEEKIREQEK 502
Score = 60.5 bits (145), Expect = 3e-09
Identities = 58/232 (25%), Positives = 100/232 (43%), Gaps = 35/232 (15%)
Query: 154 EEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEK-REERRRRELE 212
E+E+ E ++ E E K REL + + E K R+ E++R EEK RE+ +R+E E
Sbjct: 327 EKEEKMRRQEEMMWEKEEKIRELEEK----MHEQEKIREQEEKRQEEEKIREQEKRQEQE 382
Query: 213 KKRLREEEKRRR-----REEERCKKKETDK-------------------------QKKIA 242
K R+EEK R RE+E +++ +K ++KI
Sbjct: 383 AKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIR 442
Query: 243 EKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQE 302
E+E +I+ ++ + +E ++ +E+ E + +QE+ K R E + E ++
Sbjct: 443 EQEKKIREQEEKIREQEEMMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEK 502
Query: 303 TSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQR 354
+K E QEQE + + E E RR E++ R
Sbjct: 503 KIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMR 554
Score = 55.8 bits (133), Expect = 7e-08
Identities = 54/215 (25%), Positives = 98/215 (45%), Gaps = 6/215 (2%)
Query: 154 EEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEK--REERRRREL 211
+EEK E + E E K RE + E + K EK R +EE +E + REL
Sbjct: 293 QEEKIQEREEKIQ-EQEEKIREQEEKMRRQ--EEMMWEKEEKMRRQEEMMWEKEEKIREL 349
Query: 212 EKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEE 271
E+K + E+EK R +EE+R ++++ +Q+K E+E ++ ++ + +E + +E +E
Sbjct: 350 EEK-MHEQEKIREQEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEEMMQE 408
Query: 272 IDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVD 331
+ G+QE + + E + +E K E+ +EQE Q
Sbjct: 409 QEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEEMMQEQEEK 468
Query: 332 DGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKK 366
G + E E + E++ R + +++ KK
Sbjct: 469 MGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQEKK 503
Score = 52.0 bits (123), Expect = 1e-06
Identities = 50/205 (24%), Positives = 99/205 (48%), Gaps = 21/205 (10%)
Query: 154 EEEKTSANPETLLGEMEAKTREL--IARRTTPLLEYIKNRKLEKQRIREEKREERRRREL 211
E+E E + E E K RE + + + + + E++ +E+ E+ RR+E
Sbjct: 380 EQEAKMWRQEEKIREQEEKIREQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQE- 438
Query: 212 EKKRLREEEKRRRREEERCKKKE---TDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKER 268
+++RE+EK+ R +EE+ +++E ++++K+ E+E K+ ++ K +E EK + +
Sbjct: 439 --EKIREQEKKIREQEEKIREQEEMMQEQEEKMGEQEG--KMCEQEAKMQE-QEEKMRRQ 493
Query: 269 GEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRY 328
E+I +QE K R E ++E +E +K E+ QEQE + +R
Sbjct: 494 EEKI----REQEKKIREQEEKIREQEEMMQEQEEKMWEQEEKMCEQEEKMQEQEEKMRR- 548
Query: 329 HVDDGRRHRAHHEPERLSRRSEDEQ 353
+ + + RL ++ E Q
Sbjct: 549 -----QEEKMREQEVRLRQQEEKMQ 568
Score = 44.7 bits (104), Expect = 2e-04
Identities = 44/195 (22%), Positives = 89/195 (45%), Gaps = 45/195 (23%)
Query: 154 EEEKTSANPETLLGEMEAKT----------RELIARRTTPLLEYIKNRKLEKQRIREEKR 203
E+E+ E +GE E K E + R+ + E K + ++++IRE++
Sbjct: 401 EQEEMMQEQEEKMGEQEEKMWEQEEEMQEQEEKMRRQEEKIREQEKKIREQEEKIREQEE 460
Query: 204 ----EERRRRELEKK------RLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKK 253
+E + E E K +++E+E++ RR+EE+ +++E KKI E+E +I+
Sbjct: 461 MMQEQEEKMGEQEGKMCEQEAKMQEQEEKMRRQEEKIREQE----KKIREQEEKIR---- 512
Query: 254 PEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHR 313
+ EE E+ ++ E+ +++ C E ++E +E +K
Sbjct: 513 --EQEEMMQEQEEKMWEQ------EEKMC---------EQEEKMQEQEEKMRRQEEKMRE 555
Query: 314 DVERSQEQESEAQRY 328
R ++QE + Q +
Sbjct: 556 QEVRLRQQEEKMQEH 570
>gi|239747891 PREDICTED: hypothetical protein [Homo sapiens]
Length = 202
Score = 62.4 bits (150), Expect = 8e-10
Identities = 45/182 (24%), Positives = 89/182 (48%), Gaps = 10/182 (5%)
Query: 185 LEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEK 244
+E + RK E R +E +RE R+RE E + R E + R+R+ R + ++TD++K+ E+
Sbjct: 1 MERQRERKRETDRGKETERERDRQRERENQTER-ENRHRQRDRHRERDRQTDREKE-RER 58
Query: 245 EVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETS 304
+ ++ E+ E TE+ +ER + + K+++ + R + + +E +
Sbjct: 59 QKERDRQRQRERETERETERQRERQRQRER---KRQTDRERDKDRDRERKRETDRNRERN 115
Query: 305 HSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRG 364
G + + ER +++E E QR + +R R ER + QRW + + +
Sbjct: 116 RKGGRERDKQTERERDRERERQRQRERERQRQR-----ERKRETDRERQRWAEREERKKE 170
Query: 365 KK 366
+K
Sbjct: 171 RK 172
Score = 62.4 bits (150), Expect = 8e-10
Identities = 38/171 (22%), Positives = 83/171 (48%), Gaps = 18/171 (10%)
Query: 189 KNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQK-KIAEKEVR 247
++R+ ++++ RE ++E R+R+ E++ RE E++R R+ +R +K++TD+++ K ++E +
Sbjct: 46 RDRQTDREKERERQKERDRQRQRERETERETERQRERQRQRERKRQTDRERDKDRDRERK 105
Query: 248 IKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSG 307
+ + E+ + E+ K+ E D R E + +E
Sbjct: 106 RETDRNRERNRKGGRERDKQTERERD-----------------RERERQRQRERERQRQR 148
Query: 308 SDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKG 358
K D ER + E E ++ R+ + + RR + +++WG+G
Sbjct: 149 ERKRETDRERQRWAEREERKKERKKERKKERKEKKKEEKRREDKKRKWGEG 199
Score = 49.7 bits (117), Expect = 5e-06
Identities = 28/84 (33%), Positives = 50/84 (59%), Gaps = 3/84 (3%)
Query: 189 KNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRI 248
+ R + +R R+ +RE +R+RE E++R RE ++ RE +R ++E K+++ E++
Sbjct: 120 RERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERKKER 179
Query: 249 KLLKKPEKGEEPTTEKPKERGEEI 272
K KK EK E +K ++ GE I
Sbjct: 180 KEKKKEEKRRE---DKKRKWGEGI 200
Score = 30.8 bits (68), Expect = 2.6
Identities = 39/201 (19%), Positives = 86/201 (42%), Gaps = 20/201 (9%)
Query: 252 KKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKE 311
++ ++G+E E+ ++R E T ++E+ + R + E ++T +
Sbjct: 9 RETDRGKETERERDRQRERENQT---EREN-------RHRQRDRHRERDRQTDREKERER 58
Query: 312 HRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSED-----EQRWGKGPGQDRGKK 366
++ +R +++E E +R + R + E +R + R D E++ ++R +K
Sbjct: 59 QKERDRQRQRERETER-ETERQRERQRQRERKRQTDRERDKDRDRERKRETDRNRERNRK 117
Query: 367 GSQDSGAPGEA---MERLGRAQRCDDSPAPR-KERLANKDRPALQLYDPGARFRARECGG 422
G ++ E ER + QR + R ++R +++R + + R +E
Sbjct: 118 GGRERDKQTERERDRERERQRQRERERQRQRERKRETDRERQRWAEREERKKERKKERKK 177
Query: 423 NRRICKAEGSGTGPEKREEAE 443
R+ K E +KR+ E
Sbjct: 178 ERKEKKKEEKRREDKKRKWGE 198
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 62.4 bits (150), Expect = 8e-10
Identities = 53/205 (25%), Positives = 98/205 (47%), Gaps = 21/205 (10%)
Query: 163 ETLLGEMEAKTRELIARRTTPLLEYIKNRK-LEKQRIRE------EKREERRRRELEKKR 215
E L E E R+L+A R + + + R+ LE+Q+ RE ++RE+RRR + EK+R
Sbjct: 378 EQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRRREQEEKRR 437
Query: 216 LREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTG 275
L E E+RR+ EEER + +E ++ + ++ +R +L ++ E + +E+ ++
Sbjct: 438 LEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECR 497
Query: 276 GGKQESCAPGAVVKARPMEGSLEEPQ------ETSHSGSDKEHRDVERSQEQESEAQRYH 329
+ E +A ++ L++ Q + H +H +QE +H
Sbjct: 498 WREMEEHR-----QAERLQRQLQQEQAYLLSLQHDHRRPHPQHSQQPPPPQQERSKPSFH 552
Query: 330 VDDGRRHRAHHEPERLSRRSEDEQR 354
+ +AH+EP +R ED R
Sbjct: 553 APE---PKAHYEPADRAREVEDRFR 574
Score = 52.8 bits (125), Expect = 6e-07
Identities = 62/257 (24%), Positives = 108/257 (42%), Gaps = 53/257 (20%)
Query: 168 EMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREE 227
+ E K R RR L E + E +R +R++R ++ E++R EE++RR RE
Sbjct: 360 QQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREA 419
Query: 228 ERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAV 287
R ++E +++++ E++ R++ L++ K EE + R EE
Sbjct: 420 RR--QQEREQRRREQEEKRRLEELERRRKEEE-----ERRRAEE---------------- 456
Query: 288 VKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVD-DGRRHRAHHEPERLS 346
+ +E QE ++E R +E Q+Q + Q ++ R H + ERL
Sbjct: 457 -----EKRRVEREQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQ 511
Query: 347 RRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPAL 406
R+ + EQ + D + Q S P P P++ER +P+
Sbjct: 512 RQLQQEQAYLLSLQHDHRRPHPQHSQQP----------------PPPQQER----SKPSF 551
Query: 407 QLYDPGARF----RARE 419
+P A + RARE
Sbjct: 552 HAPEPKAHYEPADRARE 568
Score = 39.7 bits (91), Expect = 0.006
Identities = 46/225 (20%), Positives = 90/225 (40%), Gaps = 30/225 (13%)
Query: 153 VEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELE 212
+EE++ E E + RE +R LE + + E++R EEKR R +E
Sbjct: 409 LEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYI 468
Query: 213 KKRLREEEKR------------------RRREEERCKKKETDKQKKIAEKEVRIKLLKKP 254
+++L EE++ R RE E ++ E Q+++ +++ + L+
Sbjct: 469 RRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAER-LQRQLQQEQAYLLSLQHD 527
Query: 255 EKGEEPT-TEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEP---QETSHSGSDK 310
+ P +++P +E K AP P + + E ++T+HS +
Sbjct: 528 HRRPHPQHSQQPPPPQQE----RSKPSFHAPEPKAHYEPADRAREVEDRFRKTNHSSPEA 583
Query: 311 EHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRW 355
+ + R E ++ +G H L R +E + +W
Sbjct: 584 QSKQTGRVLEPPVPSRSESFSNGNSESVH---PALQRPAEPQVQW 625
>gi|115298682 HBxAg transactivated protein 2 [Homo sapiens]
Length = 2817
Score = 62.4 bits (150), Expect = 8e-10
Identities = 55/181 (30%), Positives = 92/181 (50%), Gaps = 21/181 (11%)
Query: 153 VEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIR----EEKREERRR 208
+EE++ +A E L + +L P E I+ R+ EK+R R E+++E+ R
Sbjct: 473 MEEQRKAACAEKL----KRLDEKLGILEKQPSPEEIREREREKEREREKELEKEQEQERE 528
Query: 209 RELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKER 268
+E EK R R++EK + E+E+ K++E +K++K EKE ++ K+ EK + E+ KE
Sbjct: 529 KEREKDRERQQEKEKELEKEQEKQREMEKERK-QEKEKELERQKEKEKELQKMKEQEKEC 587
Query: 269 GEEIDTGGGKQESCAPGAVVKARPMEGSLE---EPQETSHSGSDKEHRDVERSQEQESEA 325
E++ K E K P E +LE E QE+ +S + +E R SE
Sbjct: 588 --ELEKEREKLEE-------KIEPREPNLEPMVEKQESENSCNKEEEPVFTRQDSNRSEK 638
Query: 326 Q 326
+
Sbjct: 639 E 639
Score = 54.7 bits (130), Expect = 2e-07
Identities = 44/172 (25%), Positives = 84/172 (48%), Gaps = 15/172 (8%)
Query: 195 KQRIREEKR--EERRRRE------LEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEV 246
KQ++ +E ++RRR++ +E+ R R EE+ RR EE+R K +K K++ EK
Sbjct: 435 KQQVADEDEIWKQRRRQQSEISAAVERARKRREEEERRMEEQR-KAACAEKLKRLDEKLG 493
Query: 247 RIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQ-----ESCAPGAVVKARPMEGSLEEPQ 301
++ PE+ E EK +ER +E++ ++ E K + +E E+ +
Sbjct: 494 ILEKQPSPEEIREREREKEREREKELEKEQEQEREKEREKDRERQQEKEKELEKEQEKQR 553
Query: 302 ETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQ 353
E ++ +++ER +E+E E Q+ + + E E+L + E +
Sbjct: 554 EMEKERKQEKEKELERQKEKEKELQKMK-EQEKECELEKEREKLEEKIEPRE 604
Score = 43.9 bits (102), Expect = 3e-04
Identities = 44/205 (21%), Positives = 100/205 (48%), Gaps = 13/205 (6%)
Query: 130 RFDGYIFLDSKDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIK 189
R D + + K P ++ E +E + E + K RE R + ++
Sbjct: 487 RLDEKLGILEKQPSPEEIREREREKEREREKELEKEQEQEREKEREKDRERQQEKEKELE 546
Query: 190 NRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEER-CK-KKETDK-QKKIAEKEV 246
+ +++ + +E+++E + +ELE+++ +E+E ++ +E+E+ C+ +KE +K ++KI +E
Sbjct: 547 KEQEKQREMEKERKQE-KEKELERQKEKEKELQKMKEQEKECELEKEREKLEEKIEPREP 605
Query: 247 RIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHS 306
++ + + ++ E ++ + D+ ++E A V + P GS +P+ S
Sbjct: 606 NLEPMVEKQESENSCNKEEEPVFTRQDSNRSEKE--ATPVVHETEPESGS--QPRPAVLS 661
Query: 307 GSDKEHRD-----VERSQEQESEAQ 326
G K+ + +R QEQ + Q
Sbjct: 662 GYFKQFQKSLPPRFQRQQEQMKQQQ 686
Score = 31.6 bits (70), Expect = 1.5
Identities = 32/117 (27%), Positives = 52/117 (44%), Gaps = 11/117 (9%)
Query: 152 CVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQ---RIREEKREERRR 208
C++ ++ PE + K I P E + K E + R +REE
Sbjct: 953 CIDSKEPIERPEE-----KPKKEGFIRSSEGPKPEKVYKSKSETRWGPRPSSNRREEVND 1007
Query: 209 RELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKP 265
R + + ++ R +EER ++KE + +K AEK V K++ KPEK E+ P
Sbjct: 1008 RPVRRSGPIKKPVLRDMKEEREQRKEKEGEK--AEK-VTEKVVVKPEKTEKKDLPPP 1061
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 61.2 bits (147), Expect = 2e-09
Identities = 70/297 (23%), Positives = 129/297 (43%), Gaps = 35/297 (11%)
Query: 137 LDSKDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQ 196
L++++ E K + + +E+ E E + RE A + E K E+Q
Sbjct: 272 LEAEERERIKAEQDKKIADERARIEAEEKAAAQERERRE--AEERERMREEEKRAAEERQ 329
Query: 197 RIREEKR----------EERRRRELEKKRLREEEKR--------RRREEERCKKKETDKQ 238
RI+EE++ EE +R E++R++EEEKR R EEE+ K +E +
Sbjct: 330 RIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRN 389
Query: 239 KKIAEK-----EVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPM 293
K++ EK E +IK K +K E + K + +++ T K++ G V+A+
Sbjct: 390 KQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKLQTAVLKKQGEEKGTKVQAK-- 447
Query: 294 EGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRY-HVDDGRRHRAHHEPERLSRRSEDE 352
L+E + T K+ + +++ +E + E + + G E ++ + +
Sbjct: 448 REKLQEDKPTFKKEEIKDEK-IKKDKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKLKHT 506
Query: 353 QRWGKGPGQDRGKKGSQDSGAP----GEAMERLGRAQRCDDSPAPRKERLANKDRPA 405
+ PG + GAP G+ +E L R R ++ + E+L K + A
Sbjct: 507 ENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRR--RRGETESEEFEKLKQKQQEA 561
Score = 49.3 bits (116), Expect = 7e-06
Identities = 35/110 (31%), Positives = 64/110 (58%), Gaps = 8/110 (7%)
Query: 167 GEMEAKTRELIARRTTPL---LEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRR 223
GE E++ E + ++ LE +K ++ E++++ EE+ + R++ E ++K EEEKRR
Sbjct: 544 GETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRR 603
Query: 224 RREE-ERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEP--TTEKPKERGE 270
+EE ER + + +K++K+ E + KKP K P ++ K +ER E
Sbjct: 604 LKEEIERRRAEAAEKRQKMPEDGLSDD--KKPFKCFTPKGSSLKIEERAE 651
Score = 48.9 bits (115), Expect = 9e-06
Identities = 62/286 (21%), Positives = 121/286 (42%), Gaps = 40/286 (13%)
Query: 154 EEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKRE--------- 204
EE KT+ + G+ EA E +ARR E + ++L++ R+++ +
Sbjct: 77 EEAKTTTTNTQVEGDDEAAFLERLARR-----EERRQKRLQEALERQKEFDPTITDASLS 131
Query: 205 ---ERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKI--------AEKEVRIKLLKK 253
R + + + E+E++ +ER + +ET+ K AE+ + K+
Sbjct: 132 LPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKE 191
Query: 254 PEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEP--QETSHSGSDK- 310
E+ E+P E E+ ES V+ + + S EEP +E GSD+
Sbjct: 192 EEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEI 251
Query: 311 -EHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERL----SRRSEDEQRWGKGPGQDRGK 365
H +E ++ +EA+R ++ R R E ++ R E E+ K Q+R +
Sbjct: 252 SHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEE---KAAAQERER 308
Query: 366 KGSQDSGAPGE----AMERLGRAQRCDDSPAPRKERLANKDRPALQ 407
+ +++ E A E R + + A ++R+ +++ A +
Sbjct: 309 REAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAE 354
Score = 48.1 bits (113), Expect = 2e-05
Identities = 48/232 (20%), Positives = 98/232 (42%), Gaps = 16/232 (6%)
Query: 154 EEEKTSANPETLLGEMEAKTRELIARRTTPLLEY-----IKNRKLEKQRIREEKREERRR 208
EEE+ +GE + + ++ +TT E +KN ++ + ++E+ E+
Sbjct: 191 EEEEEEKPKRGSIGENQVEV--MVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGS 248
Query: 209 RELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKER 268
E+ EEE + R E ER + + ++++ AE++ +I + + EE + +ER
Sbjct: 249 DEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERER 308
Query: 269 GEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRY 328
E + ++E A + R E +E +++ ER + +E E +
Sbjct: 309 REAEERERMREEE-KRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAA 367
Query: 329 HVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMER 380
R RA E E ++ E + + + K Q++ GE +E+
Sbjct: 368 E----ERQRARAEEEEKAKVEEQK----RNKQLEEKKHAMQETKIKGEKVEQ 411
Score = 47.8 bits (112), Expect = 2e-05
Identities = 42/151 (27%), Positives = 74/151 (49%), Gaps = 15/151 (9%)
Query: 122 DDILLFRDRFDGYIFLDSKDPEY-----KKFLETYCVEEEKTSANPETLLG--EMEAKTR 174
+++ F DR G+ + S++ E+ K T+ + S + + G ++EA R
Sbjct: 476 EEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKR 535
Query: 175 --ELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKK 232
EL RR E + K ++Q E E +++RE +K L EEE+RR++EE K
Sbjct: 536 LEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKL 595
Query: 233 KETDKQKKIAEK------EVRIKLLKKPEKG 257
+E ++++++ E+ E K K PE G
Sbjct: 596 REEEEKRRLKEEIERRRAEAAEKRQKMPEDG 626
Score = 39.7 bits (91), Expect = 0.006
Identities = 41/204 (20%), Positives = 89/204 (43%), Gaps = 25/204 (12%)
Query: 186 EYIKNRKLEKQRIREEKREERRRRELEKKRLREEE----KRRRREEERCKKKETDKQKKI 241
++ + R+L +Q+ REE R E R ++ EEE +RRR +ER ++K+ ++
Sbjct: 3 DFERRRELRRQK-REEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61
Query: 242 AEKEVRIKLLKK-PEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEP 300
+V + P++ + TT + G D E A + + ++ +LE
Sbjct: 62 VTDQVEVNAQNSVPDEEAKTTTTNTQVEG---DDEAAFLERLARREERRQKRLQEALERQ 118
Query: 301 QETSHSGSD--------------KEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPE--R 344
+E + +D E+ E+ ++ ES +RY +++ ++ R
Sbjct: 119 KEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWR 178
Query: 345 LSRRSEDEQRWGKGPGQDRGKKGS 368
+ ++ E + + +++ K+GS
Sbjct: 179 DAEENKKEDKEKEEEEEEKPKRGS 202
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 60.5 bits (145), Expect = 3e-09
Identities = 61/245 (24%), Positives = 108/245 (44%), Gaps = 28/245 (11%)
Query: 154 EEEKTSANPETLLGEMEAK---TRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRE 210
+EE+ + GEME +EL + E K R E+Q +E ++ ++ R
Sbjct: 671 DEEREKGEKDKGRGEMERPGEGEKELAEK------EEWKKRDGEEQEQKEREQGHQKERN 724
Query: 211 LEKKRLREEEKRRRREEERCKKKETDKQ---KKIAEKEVRIKLLKKPEKGEEPTTEKP-- 265
E + EEE EEE +++E +K+ K+ E E ++ ++ E+GE E+
Sbjct: 725 QEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGE-EVEGEREKEEGERKKEERAGK 783
Query: 266 KERGEEI-DTGGGKQESCA-------PGAVVKARPME---GSLEEPQETSHSGSDKEHRD 314
+E+GEE D G G++E G V+ +E G EE +E ++ +
Sbjct: 784 EEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGE 843
Query: 315 VERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAP 374
E + +E E + ++G E E E+E+ G+G G++ G+ ++
Sbjct: 844 EEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEE--GEGEGEEEGEGEGEEEEGE 901
Query: 375 GEAME 379
GE E
Sbjct: 902 GEGEE 906
Score = 54.3 bits (129), Expect = 2e-07
Identities = 49/204 (24%), Positives = 88/204 (43%), Gaps = 15/204 (7%)
Query: 186 EYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKE 245
E+ ++ + EK + + E R E EK+ +EE ++R EE+ +K+ +K +E
Sbjct: 667 EHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQE 726
Query: 246 VRIKLLKKPEKGEEPTTEKPKERG----EEIDTGGGKQESCAPGAVVKARPMEGSLEEPQ 301
+ E GEE E +E G EE G GK+E + EG ++ +
Sbjct: 727 ME-------EGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEE 779
Query: 302 ETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQ 361
+E D +E+E+E + ++G E R E+E+ +G G+
Sbjct: 780 RAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEE---EGEGE 836
Query: 362 DRGKKGSQDSGAPGEAMERLGRAQ 385
+ +G ++ G GE E G+ +
Sbjct: 837 EEEGEGEEEEG-EGEEEEGEGKGE 859
Score = 49.3 bits (116), Expect = 7e-06
Identities = 56/263 (21%), Positives = 99/263 (37%), Gaps = 20/263 (7%)
Query: 194 EKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKK 253
E + + E+ +E R+ E++ +EE+ ++ +++ET+ + + E+ ++ +
Sbjct: 760 EGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEV 819
Query: 254 PE------------KGEEPTTEKPKERGE-EIDTGGGKQESCAPGAVVKARPMEGSLEEP 300
E +GEE E +E GE E + G GK E + EG E
Sbjct: 820 EEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGE 879
Query: 301 QETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAH--HEPERLSRRSEDEQRWGKG 358
+E ++E +E E E + +G E E E E+ G+G
Sbjct: 880 EEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEG 939
Query: 359 PGQDRGKKGSQDSGA-PGEAMERLGRAQRCDDSPAPRKERLANKDRPALQLYDPGARFRA 417
G+D +G ++ G GE E G + + E ++ G
Sbjct: 940 EGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGE----GEGEEEEG 995
Query: 418 RECGGNRRICKAEGSGTGPEKRE 440
E G + EG G G E+ E
Sbjct: 996 EEEGEEEGEGEEEGEGEGEEEEE 1018
Score = 37.0 bits (84), Expect = 0.036
Identities = 40/180 (22%), Positives = 72/180 (40%), Gaps = 5/180 (2%)
Query: 201 EKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEP 260
E+ E E E + EEE+ + EE ++ E + +++ E E + E+ E
Sbjct: 896 EEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEW 955
Query: 261 TTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHS-GSDKEHRDVERSQ 319
E+ + GE + G G+ E + EG EE +E G +E + E +
Sbjct: 956 EGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEE 1015
Query: 320 EQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAME 379
E+E E + + E E E E+R +G G++ + ++ G+ E
Sbjct: 1016 EEEGEVE----GEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQE 1071
Score = 33.1 bits (74), Expect = 0.52
Identities = 56/254 (22%), Positives = 89/254 (35%), Gaps = 29/254 (11%)
Query: 212 EKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEE 271
E+K E+ K EE+ + E + + KE L E + K K GE
Sbjct: 588 EEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSVGEA 647
Query: 272 IDTGGGKQE-SCAPGAVVKARPMEGSLEEPQETSHSGS-DKEHRDVERSQEQESEAQRYH 329
D G+ + +C G+ G+ E G DK ++ER E E E
Sbjct: 648 EDGPEGRGDGTCEEGS-------SGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKE 700
Query: 330 VDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLG------- 382
R + ER ++ + + G++ +G ++ G E E+ G
Sbjct: 701 EWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGE 760
Query: 383 ----RAQRCDDSPAPRKERLANKDRPALQLYDPG--------ARFRARECGGNRRICKA- 429
+R + +KE A K+ + D G R +E GG +
Sbjct: 761 GEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVE 820
Query: 430 EGSGTGPEKREEAE 443
EG G E+ EE E
Sbjct: 821 EGKGEREEEEEEGE 834
Score = 32.7 bits (73), Expect = 0.68
Identities = 35/158 (22%), Positives = 59/158 (37%), Gaps = 7/158 (4%)
Query: 200 EEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEE 259
EE+ E E E + EEE EE + +E + + + E+E E+GEE
Sbjct: 949 EEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGE-------EEGEE 1001
Query: 260 PTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQ 319
+ + GE + G+ E G + E EE E + E R +
Sbjct: 1002 EGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREE 1061
Query: 320 EQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGK 357
E+E E + + R E + + + ++GK
Sbjct: 1062 EEEEEGKYQETGEEENERQDGEEYKKVSKIKGSVKYGK 1099
Score = 29.6 bits (65), Expect = 5.7
Identities = 24/97 (24%), Positives = 43/97 (44%), Gaps = 7/97 (7%)
Query: 188 IKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKET---DKQKKIAEK 244
++ + E + EE EE RE E + R EEE K +ET + +++ E+
Sbjct: 1025 VEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQDGEE 1084
Query: 245 EVRIKLLKKPEK-GEEPTTEKPKERGEEIDTGGGKQE 280
++ +K K G+ T +K + G GK++
Sbjct: 1085 YKKVSKIKGSVKYGKHKTYQKKSVTNTQ---GNGKEQ 1118
>gi|169218106 PREDICTED: hypothetical protein, partial [Homo
sapiens]
Length = 436
Score = 60.1 bits (144), Expect = 4e-09
Identities = 45/230 (19%), Positives = 110/230 (47%), Gaps = 16/230 (6%)
Query: 154 EEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEK 213
E+E+ E +GE E + R+ + + +++KQ + +K+EE+ R++ E+
Sbjct: 210 EQEEQMQKQEEQMGEQEEQMRKQEEQMGE------QEEQVQKQEEQVQKQEEQMRKQEEQ 263
Query: 214 KRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEID 273
R +EE+ R + E+ +K++T+++++ E+E +++ ++ + +E + +E+ E +
Sbjct: 264 MREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQE 323
Query: 274 TGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDG 333
GKQE + + + E +E ++ E+ Q+QE + ++
Sbjct: 324 EQMGKQEE-------QMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMR 376
Query: 334 RRHRAHHEPERLSRRSED---EQRWGKGPGQDRGKKGSQDSGAPGEAMER 380
++ + E R+ E+ EQ+ G +++ ++ + G E M +
Sbjct: 377 KQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKEQMRK 426
Score = 46.6 bits (109), Expect = 5e-05
Identities = 40/230 (17%), Positives = 105/230 (45%), Gaps = 22/230 (9%)
Query: 154 EEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEK 213
E+E E +GE E + ++ + ++ +Q + K+EE+ + E+
Sbjct: 196 EQEGQMGEQEEQMGEQEEQMQK-------------QEEQMGEQEEQMRKQEEQMGEQEEQ 242
Query: 214 KRLREEEKRRRREEERCKKKE-TDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEI 272
+ +EE+ +++ E+ R ++++ ++++++ E+E ++ K+ + EE T E+ ++ E+
Sbjct: 243 VQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQEEQMREQE 302
Query: 273 DTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDD 332
+ ++E + R E + E +E ++ E+ EQ+ + +
Sbjct: 303 EQMREQEE--------QMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQM 354
Query: 333 GRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLG 382
G + + E R+ E++ R + + + ++ + GE E++G
Sbjct: 355 GEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMG 404
Score = 42.7 bits (99), Expect = 7e-04
Identities = 47/243 (19%), Positives = 107/243 (44%), Gaps = 27/243 (11%)
Query: 173 TRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEK------KRLREEEKRRRRE 226
T E + + L E ++ + EK I+ +E +R+ E +K ++RE+E + R +
Sbjct: 5 TNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVREQ 64
Query: 227 EERCKKKE---TDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCA 283
E + +++E +++ ++ E+E +++ + + +E + + + E + +QE
Sbjct: 65 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQV 124
Query: 284 PGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPE 343
+ R EG + E + G +E R QE + Q V E E
Sbjct: 125 REQEGQVREQEGQVREQE-----GQVREQEGQVREQEGQVREQEGQV---------REQE 170
Query: 344 RLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLG----RAQRCDDSPAPRKERLA 399
R E + R +G +++ + + G GE E++G + Q+ ++ ++E++
Sbjct: 171 GQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMR 230
Query: 400 NKD 402
++
Sbjct: 231 KQE 233
Score = 42.0 bits (97), Expect = 0.001
Identities = 40/226 (17%), Positives = 100/226 (44%), Gaps = 9/226 (3%)
Query: 154 EEEKTSANPETLLGEMEAKTREL---IARRTTPLLEYIKNRKLEKQRIREEK---REERR 207
E+E E + E E + RE + + + E + ++ ++RE++ RE+
Sbjct: 70 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 129
Query: 208 RRELEKKRLREEEKRRRREEERCKKKE---TDKQKKIAEKEVRIKLLKKPEKGEEPTTEK 264
+ ++ ++RE+E + R +E + +++E +++ ++ E+E +++ + + +E +
Sbjct: 130 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVRE 189
Query: 265 PKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESE 324
+ + E + G+QE + + E + E +E ++ E+ Q+QE +
Sbjct: 190 QEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQ 249
Query: 325 AQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQD 370
Q+ ++ E E R E++ K + + G Q+
Sbjct: 250 VQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQTEQEEQTGEQE 295
Score = 38.5 bits (88), Expect = 0.012
Identities = 54/319 (16%), Positives = 132/319 (41%), Gaps = 32/319 (10%)
Query: 154 EEEKTSANPETLLGEMEAKTREL---IARRTTPLLEYIKNRKLEKQRIREEK---REERR 207
E+E E + E E + RE + + + E + ++ ++RE++ RE+
Sbjct: 105 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 164
Query: 208 RRELEKKRLREEEKRRRREEERCKKKET---DKQKKIAEKEVRI----KLLKKPEK---G 257
+ ++ ++RE+E + R +E + +++E +++ ++ E+E ++ + ++K E+
Sbjct: 165 QVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQKQEEQMGE 224
Query: 258 EEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVER 317
+E K +E+ E + KQE + R E + E +E ++ + E+
Sbjct: 225 QEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQMLKQKEQ 284
Query: 318 SQEQ----ESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQ------------ 361
++++ E E Q ++ R + E+ + E E++ GK Q
Sbjct: 285 TEQEEQTGEQEEQMREQEEQMREQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQK 344
Query: 362 DRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKERLANKDRPALQLYDPGARFRARECG 421
++ K + G E M++ R + ++E K ++ + + + G
Sbjct: 345 EQMWKQEEQMGEQEEQMQKQEEQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMG 404
Query: 422 GNRRICKAEGSGTGPEKRE 440
+ + + G +K +
Sbjct: 405 EQKEQMREQEEQMGEQKEQ 423
Score = 37.7 bits (86), Expect = 0.021
Identities = 40/216 (18%), Positives = 94/216 (43%), Gaps = 15/216 (6%)
Query: 154 EEEKTSANPETLLGEMEAKTREL---IARRTTPLLEYIKNRKLEKQRIREEK---REERR 207
E+E E + E E + RE + + + E + ++ ++RE++ RE+
Sbjct: 98 EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG 157
Query: 208 RRELEKKRLREEEKRRRREEERCKKKE---TDKQKKIAEKEVRIKLLKKPEKGEEPTTEK 264
+ ++ ++RE+E + R +E + +++E +++ ++ E+E ++ ++ +E +K
Sbjct: 158 QVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQMGEQEGQMGEQEEQMGEQEEQMQK 217
Query: 265 PKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQE-- 322
+E+ E + KQE + + E +++ +E ++ E+ +EQE
Sbjct: 218 QEEQMGEQEEQMRKQEEQMGEQEEQVQKQEEQVQKQEEQMRKQEEQMREQEEQMREQEEQ 277
Query: 323 ----SEAQRYHVDDGRRHRAHHEPERLSRRSEDEQR 354
E G + E E R E++ R
Sbjct: 278 MLKQKEQTEQEEQTGEQEEQMREQEEQMREQEEQMR 313
Score = 37.0 bits (84), Expect = 0.036
Identities = 29/128 (22%), Positives = 69/128 (53%), Gaps = 7/128 (5%)
Query: 154 EEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRK-LEKQRIREEKREERRRRELE 212
E+E+ E +G+ E + E + + K + + +Q + +K+EE+ R++ E
Sbjct: 314 EQEEQMREQEEQMGKQEEQMWEQKEQMWEQKEQMWKQEEQMGEQEEQMQKQEEQVRKQEE 373
Query: 213 KKRLREEEKRRRREEERCKKKETDKQK-KIAEKEVRIKLLKKPEKGEEPTTEKPKERGEE 271
+ R +EE+ R++ E+ R ++++ +QK ++ E++ +++ E+ E+ +K + R +E
Sbjct: 374 QMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMR-----EQEEQMGEQKEQMRKQE 428
Query: 272 IDTGGGKQ 279
G K+
Sbjct: 429 EHMGEQKE 436
Score = 32.7 bits (73), Expect = 0.68
Identities = 49/213 (23%), Positives = 90/213 (42%), Gaps = 10/213 (4%)
Query: 197 RIREEKREERRRRELEKKRLREEEKR--RRREEERCKKKETDKQKKIAEKEVRIKLLKKP 254
RI E+ +E+ E+ +L E EK + +E +K ETDK E +VR + +
Sbjct: 3 RITNEELKEKNAELQEELQLVETEKSEIQLHIKELKRKLETDKIPLPQEGQVREQEGQVR 62
Query: 255 EKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSL--EEPQETSHSGSDKEH 312
E+ + ++ + R +E +QE + R EG + +E Q G +E
Sbjct: 63 EQEGQVREQEGQVREQEGQVR--EQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQ 120
Query: 313 RDVERSQE---QESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQ 369
R QE +E E Q + R + E+ + E E + + GQ R ++G Q
Sbjct: 121 EGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEGQVREQEG-Q 179
Query: 370 DSGAPGEAMERLGRAQRCDDSPAPRKERLANKD 402
G+ E+ G+ + ++E++ ++
Sbjct: 180 VREQEGQVREQEGQMGEQEGQMGEQEEQMGEQE 212
Score = 32.0 bits (71), Expect = 1.2
Identities = 27/133 (20%), Positives = 70/133 (52%), Gaps = 10/133 (7%)
Query: 154 EEEKTSANPETLLGEME---AKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRE 210
E+E+ E + E E K E + + + E K + +++ E+ E+ +++E
Sbjct: 307 EQEEQMREQEEQMREQEEQMGKQEEQMWEQKEQMWEQ-KEQMWKQEEQMGEQEEQMQKQE 365
Query: 211 LEKKRLREEEKRRRREEERCKKKETDKQK---KIAEKEVRIKLLKKPEKGEEPTTEKPKE 267
+++R++E++ R++EE+ +K+E +K ++ E++ ++ K+ + +E + KE
Sbjct: 366 ---EQVRKQEEQMRKQEEQMRKQEEQMRKQEEQMGEQKEQMGEQKEQMREQEEQMGEQKE 422
Query: 268 RGEEIDTGGGKQE 280
+ + + G+Q+
Sbjct: 423 QMRKQEEHMGEQK 435
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 60.1 bits (144), Expect = 4e-09
Identities = 48/186 (25%), Positives = 90/186 (48%), Gaps = 21/186 (11%)
Query: 191 RKLEKQRIREEKREERRRRELEKKRLREEEKRRR--REEERCKKKETDKQKKIAEKEVRI 248
RK E +++R +K EE +RR LE+ +L+ EE+ R+ + ER ++ + +K+K+I +K +I
Sbjct: 547 RKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQI 606
Query: 249 KLLKKPEKGEEPTTEKPKERG-----EEIDTGGGKQESCAPGAVVKARPMEGSLEEPQET 303
+ K E EK K++ EE++ ++E +AR + +E +E
Sbjct: 607 DEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE--------EARRLRWLQQEEEER 658
Query: 304 SHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDR 363
H +++ +E+E E R + R + R R E E+R + Q+R
Sbjct: 659 RH------QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQER 712
Query: 364 GKKGSQ 369
++ Q
Sbjct: 713 REQERQ 718
Score = 53.1 bits (126), Expect = 5e-07
Identities = 56/253 (22%), Positives = 108/253 (42%), Gaps = 14/253 (5%)
Query: 153 VEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKN------RKLEKQRIREEKREER 206
VE+E+ E E R+ + LE +K RK+ + R R E+ +E
Sbjct: 535 VEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEE 594
Query: 207 RRRELEKKRLREEEKRRRREEERCKKKETDKQ---KKIAEKEVRIKLLKKPEKGEEPTTE 263
+++++E+K + +EK + +EER +++ K+ KK+ E E R K ++ + E
Sbjct: 595 KKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQE 654
Query: 264 KPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQES 323
+ + R +E+ ++E +A+ + E + ++E R+ ER +++
Sbjct: 655 EEERRHQELLQKKKEEEQERLRKAAEAKRL-AEQREQERREQERREQERREQERREQERR 713
Query: 324 EAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGR 383
E +R + RR E ERL E ++R Q + + E +RL
Sbjct: 714 EQERQLAEQERR----REQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAE 769
Query: 384 AQRCDDSPAPRKE 396
Q ++ KE
Sbjct: 770 RQLQEEQEKKAKE 782
Score = 48.5 bits (114), Expect = 1e-05
Identities = 44/201 (21%), Positives = 96/201 (47%), Gaps = 31/201 (15%)
Query: 140 KDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTR-------ELIARRTTP----LLEYI 188
K+ + K+ + + +EKT E L E +AK + E+ ARR L ++
Sbjct: 592 KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWL 651
Query: 189 KNRKLEKQ-----RIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAE 243
+ + E++ + ++E+ +ER R+ E KRL E+ ++ RRE+ER +++ +++++ E
Sbjct: 652 QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQE 711
Query: 244 KEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQET 303
+ + + L + E+ E + + +E + Q+ ++ LEE ++
Sbjct: 712 RREQERQLAEQERRREQERLQAERELQEREKALRLQK----------EQLQRELEEKKK- 760
Query: 304 SHSGSDKEHRDVERSQEQESE 324
+++ R ER ++E E
Sbjct: 761 ----KEEQQRLAERQLQEEQE 777
Score = 38.5 bits (88), Expect = 0.012
Identities = 39/179 (21%), Positives = 82/179 (45%), Gaps = 23/179 (12%)
Query: 138 DSKDPEYKKFLETYCVEEE---KTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLE 194
+ ++ +++ L+ EE+ + +A + L + E + RE R + R+ +
Sbjct: 654 EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERRE--------QERREQ 705
Query: 195 KQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKP 254
++R +E + +ER+ E E++R +E + R +ER K K++ E E + K ++
Sbjct: 706 ERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQ 765
Query: 255 EKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHR 313
E E+ +++ +E A GA KA + ++ P TS+ + + HR
Sbjct: 766 RLAERQLQEEQEKKAKE-----------AAGA-SKALNVTVDVQSPACTSYQMTPQGHR 812
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 60.1 bits (144), Expect = 4e-09
Identities = 48/186 (25%), Positives = 90/186 (48%), Gaps = 21/186 (11%)
Query: 191 RKLEKQRIREEKREERRRRELEKKRLREEEKRRR--REEERCKKKETDKQKKIAEKEVRI 248
RK E +++R +K EE +RR LE+ +L+ EE+ R+ + ER ++ + +K+K+I +K +I
Sbjct: 543 RKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQI 602
Query: 249 KLLKKPEKGEEPTTEKPKERG-----EEIDTGGGKQESCAPGAVVKARPMEGSLEEPQET 303
+ K E EK K++ EE++ ++E +AR + +E +E
Sbjct: 603 DEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEE--------EARRLRWLQQEEEER 654
Query: 304 SHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDR 363
H +++ +E+E E R + R + R R E E+R + Q+R
Sbjct: 655 RH------QELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQER 708
Query: 364 GKKGSQ 369
++ Q
Sbjct: 709 REQERQ 714
Score = 52.4 bits (124), Expect = 8e-07
Identities = 53/238 (22%), Positives = 103/238 (43%), Gaps = 14/238 (5%)
Query: 168 EMEAKTRELIARRTTPLLEYIKN------RKLEKQRIREEKREERRRRELEKKRLREEEK 221
E E R+ + LE +K RK+ + R R E+ +E +++++E+K + +EK
Sbjct: 546 EAEQLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEK 605
Query: 222 RRRREEERCKKKETDKQ---KKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGK 278
+ +EER +++ K+ KK+ E E R K ++ + E+ + R +E+ +
Sbjct: 606 TEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKE 665
Query: 279 QESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRA 338
+E +A+ + E + ++E R+ ER +++ E +R + RR
Sbjct: 666 EEQERLRKAAEAKRL-AEQREQERREQERREQERREQERREQERREQERQLAEQERR--- 721
Query: 339 HHEPERLSRRSEDEQRWGKGPGQDRGKKGSQDSGAPGEAMERLGRAQRCDDSPAPRKE 396
E ERL E ++R Q + + E +RL Q ++ KE
Sbjct: 722 -REQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKE 778
Score = 48.5 bits (114), Expect = 1e-05
Identities = 44/201 (21%), Positives = 96/201 (47%), Gaps = 31/201 (15%)
Query: 140 KDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTR-------ELIARRTTP----LLEYI 188
K+ + K+ + + +EKT E L E +AK + E+ ARR L ++
Sbjct: 588 KEEKKKQIEQKFAQIDEKTEKAKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWL 647
Query: 189 KNRKLEKQ-----RIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAE 243
+ + E++ + ++E+ +ER R+ E KRL E+ ++ RRE+ER +++ +++++ E
Sbjct: 648 QQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERREQERREQERREQE 707
Query: 244 KEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQET 303
+ + + L + E+ E + + +E + Q+ ++ LEE ++
Sbjct: 708 RREQERQLAEQERRREQERLQAERELQEREKALRLQK----------EQLQRELEEKKK- 756
Query: 304 SHSGSDKEHRDVERSQEQESE 324
+++ R ER ++E E
Sbjct: 757 ----KEEQQRLAERQLQEEQE 773
Score = 38.5 bits (88), Expect = 0.012
Identities = 39/179 (21%), Positives = 82/179 (45%), Gaps = 23/179 (12%)
Query: 138 DSKDPEYKKFLETYCVEEE---KTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLE 194
+ ++ +++ L+ EE+ + +A + L + E + RE R + R+ +
Sbjct: 650 EEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERREQERRE--------QERREQ 701
Query: 195 KQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKP 254
++R +E + +ER+ E E++R +E + R +ER K K++ E E + K ++
Sbjct: 702 ERREQERREQERQLAEQERRREQERLQAERELQEREKALRLQKEQLQRELEEKKKKEEQQ 761
Query: 255 EKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHR 313
E E+ +++ +E A GA KA + ++ P TS+ + + HR
Sbjct: 762 RLAERQLQEEQEKKAKE-----------AAGA-SKALNVTVDVQSPACTSYQMTPQGHR 808
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 59.7 bits (143), Expect = 5e-09
Identities = 48/174 (27%), Positives = 82/174 (47%), Gaps = 14/174 (8%)
Query: 194 EKQRIREEKREERRRRELEKKRLRE---EEKRRRREEERCK-----KKETDKQKKIAEKE 245
E +R +E + E+R+RE EK+R RE +EK++R++ ER K +KE +KQ+K ++
Sbjct: 33 ESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREK 92
Query: 246 VRIKLLKKPEKGEEP-----TTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEP 300
R K K+ +K E +K KER E ++E K R E E
Sbjct: 93 ERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERK-REK 151
Query: 301 QETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQR 354
+ K+ + ER +++E + + R+ R + ER R + ++R
Sbjct: 152 ERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKER 205
Score = 58.2 bits (139), Expect = 2e-08
Identities = 62/241 (25%), Positives = 106/241 (43%), Gaps = 28/241 (11%)
Query: 185 LEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEK 244
L+ + + K + E ++ RRE EK++ RE EK R+RE + +KK+ K+++ E+
Sbjct: 17 LQMVSCSHISKPCTQRESERKKERREREKRK-REREKERKRERGKKEKKKRKKRERGKER 75
Query: 245 EVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETS 304
E + K +K K E E+ K + E+ K+E R G E ++
Sbjct: 76 ERKRKEREKQRK-ERREKERRKRKKEK-----KKRE----------RKQRGRRERKKK-- 117
Query: 305 HSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRG 364
KE ++ ER +Q E +R R+ + E +R R + E++ K ++R
Sbjct: 118 -----KERKERERENKQRRERKR---KKRRKKKRRKERKREKERGKRERKRKKRKKEERE 169
Query: 365 KKGSQDSGAPGEAMERLGRAQRCDD-SPAPRKERLANKDRPALQLYDPGARFRARECGGN 423
KK ++ + ER R +R + RK++ KDR + D RE N
Sbjct: 170 KKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQVFRPLRESAFN 229
Query: 424 R 424
R
Sbjct: 230 R 230
Score = 57.4 bits (137), Expect = 3e-08
Identities = 32/113 (28%), Positives = 68/113 (60%), Gaps = 7/113 (6%)
Query: 168 EMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEE------- 220
E + + R+ RR + K R+ E ++ RE KR++RR+++ K+R RE+E
Sbjct: 100 EKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERK 159
Query: 221 KRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEID 273
+++R++EER KK+E +++++ E+E + + +K E+ +E +K +++ + D
Sbjct: 160 RKKRKKEEREKKRERNRKERKKERERKERRERKKERKKERRKKKERKKDRKTD 212
Score = 57.0 bits (136), Expect = 3e-08
Identities = 48/190 (25%), Positives = 93/190 (48%), Gaps = 19/190 (10%)
Query: 168 EMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREER---RRRELEKKRLREEEKRRR 224
E + RE +R E K +K E+ + RE KR+ER R+ EK+R + ++++++
Sbjct: 44 EKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKK 103
Query: 225 REEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAP 284
RE ++ ++E K+K+ E+E K ++ ++ + ++ KER E + GK+E
Sbjct: 104 RERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKER--GKRE---- 157
Query: 285 GAVVKARPMEGSLEEPQETSHSGSDKEH-RDVERSQEQESEAQRYHVDDGRRHRAHHEPE 343
R + +E +E + KE ++ ER + +E + +R RR + + +
Sbjct: 158 ------RKRKKRKKEEREKKRERNRKERKKERERKERRERKKER---KKERRKKKERKKD 208
Query: 344 RLSRRSEDEQ 353
R + R D Q
Sbjct: 209 RKTDRQTDSQ 218
Score = 54.3 bits (129), Expect = 2e-07
Identities = 46/184 (25%), Positives = 86/184 (46%), Gaps = 8/184 (4%)
Query: 170 EAKTRELIARRTTPLLEYIKNRKLEKQRIREEKREERRRRELEKKRLREEEKRRRREEER 229
E + RE R + + +K +K+R + E+ +ER R K++ RE++++ RRE+ER
Sbjct: 39 ERREREKRKREREKERKRERGKKEKKKRKKRERGKERER----KRKEREKQRKERREKER 94
Query: 230 CKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVK 289
K+K K+KK E++ R + +K +K + + K+R E K++ K
Sbjct: 95 RKRK---KEKKKRERKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREK 151
Query: 290 ARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRS 349
R + ++ +E ER +E+E + +R + ++ R + ER R
Sbjct: 152 ERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKERKKER-RKKKERKKDRK 210
Query: 350 EDEQ 353
D Q
Sbjct: 211 TDRQ 214
>gi|239745153 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 59.7 bits (143), Expect = 5e-09
Identities = 52/204 (25%), Positives = 103/204 (50%), Gaps = 14/204 (6%)
Query: 154 EEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEK--REERRRREL 211
E+E+ E + E E K RE + E I+ ++ EK R +EEK R+E + RE
Sbjct: 322 EQEEKMWRQEEKMHEQEEKIREQEDKMWRQE-EKIREQE-EKIREQEEKMWRQEEKIREQ 379
Query: 212 EKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEE 271
++K ++E+E+ R+EE+ +++E +Q+K+ +E +++ + + +E + +E+ E
Sbjct: 380 DEK-IQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRE 438
Query: 272 IDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVD 331
++ QE K R +E ++E +E +K R E+ QEQE + R
Sbjct: 439 LEEMMQDQEE-------KLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKL 491
Query: 332 DGRRHRAHHEPERLSRRSEDEQRW 355
+ + + E++ R ++E+ W
Sbjct: 492 LKQEEKIWEQEEKMWR--QEEKMW 513
Score = 43.9 bits (102), Expect = 3e-04
Identities = 56/225 (24%), Positives = 100/225 (44%), Gaps = 40/225 (17%)
Query: 154 EEEKTSANPETLLGEMEAKTRELIARRTTPLLEYI-KNRKLEKQRIREEKR--------- 203
E+E+ E + E E K +E + R+ + E K R+ E++ R+E++
Sbjct: 385 EQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQ 444
Query: 204 --EERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPT 261
EE+ R E+E+K ++EEE++ + +EE+ +++E Q++ + + KLLK+ EK E
Sbjct: 445 DQEEKLR-EVEEK-MQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWE-- 500
Query: 262 TEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQ 321
E+ R EE K E ++E +E +K R +Q
Sbjct: 501 QEEKMWRQEE-----------------KMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQ 543
Query: 322 ESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKK 366
E + Q V R ERL + + + G G G++ G +
Sbjct: 544 EEKMQEQEV------RLQELEERLGKLGQKAELLG-GAGRESGSQ 581
Score = 42.0 bits (97), Expect = 0.001
Identities = 58/274 (21%), Positives = 128/274 (46%), Gaps = 21/274 (7%)
Query: 135 IFLDSKDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLE 194
I L+ KD + K + +++ + L E+++ + +L A+ L + N++ E
Sbjct: 237 IQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQE 296
Query: 195 KQRIREEKREERRRRELEKKRLREEEKRRRREEE--RCKKKETDKQKKIAEKEVRIKLLK 252
++ R+E++ + E E+K +E K R +EE+ R ++K ++++KI E+E K+ +
Sbjct: 297 EKMWRQEEKIQ----EQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQE--DKMWR 350
Query: 253 KPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSL----EEPQETSHSGS 308
+ EK E EK +E+ E++ +QE K + E + E+ +E
Sbjct: 351 QEEKIRE-QEEKIREQEEKM----WRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQ 405
Query: 309 DKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGS 368
+K R ++ +EQ+ + + + R+ E E + + E++ R + Q+ +K
Sbjct: 406 EKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQ 465
Query: 369 QDSGAPGEAMERLGRAQRCDDSPAPRKERLANKD 402
+ E ++R + + R+E+L ++
Sbjct: 466 EQE----EKIQRQEEKIQEQEEKTWRQEKLLKQE 495
Score = 37.0 bits (84), Expect = 0.036
Identities = 45/198 (22%), Positives = 93/198 (46%), Gaps = 20/198 (10%)
Query: 148 LETYCVEEEKTSANPETLLGEMEAKTREL---IARRTTPLLEYIKNRKLEKQRIREEK-- 202
LE ++E+ E + E E K +E I R+ + E E++ R+EK
Sbjct: 439 LEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQ------EEKTWRQEKLL 492
Query: 203 REERRRRELEKKRLREEEKRRRREEERCKKKE--TDKQKKIAEKEVRIKLLKKPEKGEEP 260
++E + E E+K R+EEK +EE+ +++E +++K+ E+EVR+ ++ + +E
Sbjct: 493 KQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEV 552
Query: 261 TTEKPKER----GEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVE 316
++ +ER G++ + GG + P+ L+ ++ + S ++ +D
Sbjct: 553 RLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTPI---LQVELKSQEAQSLQQQQDHY 609
Query: 317 RSQEQESEAQRYHVDDGR 334
R Q+ A + G+
Sbjct: 610 RGHLQQYVAAYQQLASGK 627
>gi|239745127 PREDICTED: similar to Putative golgin subfamily A
member 6-like protein 6 [Homo sapiens]
Length = 655
Score = 59.7 bits (143), Expect = 5e-09
Identities = 52/204 (25%), Positives = 103/204 (50%), Gaps = 14/204 (6%)
Query: 154 EEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLEKQRIREEK--REERRRREL 211
E+E+ E + E E K RE + E I+ ++ EK R +EEK R+E + RE
Sbjct: 322 EQEEKMWRQEEKMHEQEEKIREQEDKMWRQE-EKIREQE-EKIREQEEKMWRQEEKIREQ 379
Query: 212 EKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPTTEKPKERGEE 271
++K ++E+E+ R+EE+ +++E +Q+K+ +E +++ + + +E + +E+ E
Sbjct: 380 DEK-IQEQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRE 438
Query: 272 IDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQESEAQRYHVD 331
++ QE K R +E ++E +E +K R E+ QEQE + R
Sbjct: 439 LEEMMQDQEE-------KLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKL 491
Query: 332 DGRRHRAHHEPERLSRRSEDEQRW 355
+ + + E++ R ++E+ W
Sbjct: 492 LKQEEKIWEQEEKMWR--QEEKMW 513
Score = 43.9 bits (102), Expect = 3e-04
Identities = 56/225 (24%), Positives = 100/225 (44%), Gaps = 40/225 (17%)
Query: 154 EEEKTSANPETLLGEMEAKTRELIARRTTPLLEYI-KNRKLEKQRIREEKR--------- 203
E+E+ E + E E K +E + R+ + E K R+ E++ R+E++
Sbjct: 385 EQEEEMWRQEEKIREQEEKRQEKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQ 444
Query: 204 --EERRRRELEKKRLREEEKRRRREEERCKKKETDKQKKIAEKEVRIKLLKKPEKGEEPT 261
EE+ R E+E+K ++EEE++ + +EE+ +++E Q++ + + KLLK+ EK E
Sbjct: 445 DQEEKLR-EVEEK-MQEEEEKMQEQEEKIQRQEEKIQEQEEKTWRQEKLLKQEEKIWE-- 500
Query: 262 TEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVERSQEQ 321
E+ R EE K E ++E +E +K R +Q
Sbjct: 501 QEEKMWRQEE-----------------KMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQ 543
Query: 322 ESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKK 366
E + Q V R ERL + + + G G G++ G +
Sbjct: 544 EEKMQEQEV------RLQELEERLGKLGQKAELLG-GAGRESGSQ 581
Score = 42.0 bits (97), Expect = 0.001
Identities = 58/274 (21%), Positives = 128/274 (46%), Gaps = 21/274 (7%)
Query: 135 IFLDSKDPEYKKFLETYCVEEEKTSANPETLLGEMEAKTRELIARRTTPLLEYIKNRKLE 194
I L+ KD + K + +++ + L E+++ + +L A+ L + N++ E
Sbjct: 237 IQLNVKDLKRKLERAQLLLPQQQLQVEADRLGKELQSVSAKLQAQVEENELWNLLNQQQE 296
Query: 195 KQRIREEKREERRRRELEKKRLREEEKRRRREEE--RCKKKETDKQKKIAEKEVRIKLLK 252
++ R+E++ + E E+K +E K R +EE+ R ++K ++++KI E+E K+ +
Sbjct: 297 EKMWRQEEKIQ----EQEEKMCEQELKIREQEEKMWRQEEKMHEQEEKIREQE--DKMWR 350
Query: 253 KPEKGEEPTTEKPKERGEEIDTGGGKQESCAPGAVVKARPMEGSL----EEPQETSHSGS 308
+ EK E EK +E+ E++ +QE K + E + E+ +E
Sbjct: 351 QEEKIRE-QEEKIREQEEKM----WRQEEKIREQDEKIQEQEEEMWRQEEKIREQEEKRQ 405
Query: 309 DKEHRDVERSQEQESEAQRYHVDDGRRHRAHHEPERLSRRSEDEQRWGKGPGQDRGKKGS 368
+K R ++ +EQ+ + + + R+ E E + + E++ R + Q+ +K
Sbjct: 406 EKMWRQEKKMREQDEKIREQEEEMWRQEEKIRELEEMMQDQEEKLREVEEKMQEEEEKMQ 465
Query: 369 QDSGAPGEAMERLGRAQRCDDSPAPRKERLANKD 402
+ E ++R + + R+E+L ++
Sbjct: 466 EQE----EKIQRQEEKIQEQEEKTWRQEKLLKQE 495
Score = 37.0 bits (84), Expect = 0.036
Identities = 45/198 (22%), Positives = 93/198 (46%), Gaps = 20/198 (10%)
Query: 148 LETYCVEEEKTSANPETLLGEMEAKTREL---IARRTTPLLEYIKNRKLEKQRIREEK-- 202
LE ++E+ E + E E K +E I R+ + E E++ R+EK
Sbjct: 439 LEEMMQDQEEKLREVEEKMQEEEEKMQEQEEKIQRQEEKIQEQ------EEKTWRQEKLL 492
Query: 203 REERRRRELEKKRLREEEKRRRREEERCKKKE--TDKQKKIAEKEVRIKLLKKPEKGEEP 260
++E + E E+K R+EEK +EE+ +++E +++K+ E+EVR+ ++ + +E
Sbjct: 493 KQEEKIWEQEEKMWRQEEKMWEQEEKMQEQEEKMQRQEEKMREQEVRLWQQEEKMQEQEV 552
Query: 261 TTEKPKER----GEEIDTGGGKQESCAPGAVVKARPMEGSLEEPQETSHSGSDKEHRDVE 316
++ +ER G++ + GG + P+ L+ ++ + S ++ +D
Sbjct: 553 RLQELEERLGKLGQKAELLGGAGRESGSQRLPTLTPI---LQVELKSQEAQSLQQQQDHY 609
Query: 317 RSQEQESEAQRYHVDDGR 334
R Q+ A + G+
Sbjct: 610 RGHLQQYVAAYQQLASGK 627
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.311 0.131 0.372
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 21,105,565
Number of Sequences: 37866
Number of extensions: 1218681
Number of successful extensions: 27811
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 779
Number of HSP's successfully gapped in prelim test: 980
Number of HSP's that attempted gapping in prelim test: 8103
Number of HSP's gapped (non-prelim): 8058
length of query: 443
length of database: 18,247,518
effective HSP length: 105
effective length of query: 338
effective length of database: 14,271,588
effective search space: 4823796744
effective search space used: 4823796744
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 63 (28.9 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.