Guide to the Human Genome
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Search of human proteins with 18093112

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|18093112 ABT1-associated protein [Homo sapiens]
         (851 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|18093112 ABT1-associated protein [Homo sapiens]                   1687   0.0  
gi|169173337 PREDICTED: similar to ABT1-associated protein [Homo...   176   1e-43
gi|169172536 PREDICTED: similar to ABT1-associated protein [Homo...   176   1e-43
gi|169173104 PREDICTED: similar to ABT1-associated protein [Homo...   176   1e-43
gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens]           72   2e-12
gi|72534750 splicing factor YT521-B isoform 1 [Homo sapiens]           72   2e-12
gi|148746195 trichohyalin [Homo sapiens]                               68   4e-11
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]                       65   2e-10
gi|253970456 HIV-1 Tat specific factor 1 [Homo sapiens]                65   3e-10
gi|21361437 HIV-1 Tat specific factor 1 [Homo sapiens]                 65   3e-10
gi|7661950 SH2 domain binding protein 1 [Homo sapiens]                 65   3e-10
gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]    64   6e-10
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa...    64   6e-10
gi|24415404 MDN1, midasin homolog [Homo sapiens]                       63   1e-09
gi|114155142 nuclear pore complex-associated protein TPR [Homo s...    62   2e-09
gi|115529449 upstream binding transcription factor, RNA polymera...    62   3e-09
gi|115529451 upstream binding transcription factor, RNA polymera...    62   3e-09
gi|7657671 upstream binding transcription factor, RNA polymerase...    62   3e-09
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho...    61   4e-09
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho...    61   4e-09
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho...    61   4e-09
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho...    61   4e-09
gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]    60   9e-09
gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]    60   9e-09
gi|71061468 centromere protein E [Homo sapiens]                        60   9e-09
gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]    59   1e-08
gi|51477718 TATA box binding protein-associated factor, RNA poly...    59   1e-08
gi|34577114 cytomatrix protein p110 [Homo sapiens]                     59   2e-08
gi|104526627 triadin [Homo sapiens]                                    59   2e-08
gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo sa...    58   3e-08

>gi|18093112 ABT1-associated protein [Homo sapiens]
          Length = 851

 Score = 1687 bits (4370), Expect = 0.0
 Identities = 851/851 (100%), Positives = 851/851 (100%)

Query: 1   MSSKQEIMSDQRFRRVAKDPRFWEMPEKDRKVKIDKRFRAMFHDKKFKLNYAVDKRGRPI 60
           MSSKQEIMSDQRFRRVAKDPRFWEMPEKDRKVKIDKRFRAMFHDKKFKLNYAVDKRGRPI
Sbjct: 1   MSSKQEIMSDQRFRRVAKDPRFWEMPEKDRKVKIDKRFRAMFHDKKFKLNYAVDKRGRPI 60

Query: 61  SHSTTEDLKRFYDLSDSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKA 120
           SHSTTEDLKRFYDLSDSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKA
Sbjct: 61  SHSTTEDLKRFYDLSDSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKA 120

Query: 121 NHKGSENKTDLDNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSS 180
           NHKGSENKTDLDNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSS
Sbjct: 121 NHKGSENKTDLDNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSS 180

Query: 181 LEEKQRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKDALE 240
           LEEKQRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKDALE
Sbjct: 181 LEEKQRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKDALE 240

Query: 241 EDSESVSEIGSDEESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDSGP 300
           EDSESVSEIGSDEESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDSGP
Sbjct: 241 EDSESVSEIGSDEESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDSGP 300

Query: 301 DLARGKGNIETSSEDEDDTADLFPEESGFEHAWRELDKDAPRADEITRRLAVCNMDWDRL 360
           DLARGKGNIETSSEDEDDTADLFPEESGFEHAWRELDKDAPRADEITRRLAVCNMDWDRL
Sbjct: 301 DLARGKGNIETSSEDEDDTADLFPEESGFEHAWRELDKDAPRADEITRRLAVCNMDWDRL 360

Query: 361 KAKDLLALFNSFKPKGGVIFSVKIYPSEFGKERMKEEQVQGPVELLSIPEDAPEKDWTSR 420
           KAKDLLALFNSFKPKGGVIFSVKIYPSEFGKERMKEEQVQGPVELLSIPEDAPEKDWTSR
Sbjct: 361 KAKDLLALFNSFKPKGGVIFSVKIYPSEFGKERMKEEQVQGPVELLSIPEDAPEKDWTSR 420

Query: 421 EKLRDYQFKRLKYYYAVVDCDSPETASKIYEDCDGLEFESSCSFIDLRFIPDDITFDDEP 480
           EKLRDYQFKRLKYYYAVVDCDSPETASKIYEDCDGLEFESSCSFIDLRFIPDDITFDDEP
Sbjct: 421 EKLRDYQFKRLKYYYAVVDCDSPETASKIYEDCDGLEFESSCSFIDLRFIPDDITFDDEP 480

Query: 481 KDVASEVNLTAYKPKYFTSAAMGTSTVEITWDETDHERITMLNRKFKKEELLDMDFQAYL 540
           KDVASEVNLTAYKPKYFTSAAMGTSTVEITWDETDHERITMLNRKFKKEELLDMDFQAYL
Sbjct: 481 KDVASEVNLTAYKPKYFTSAAMGTSTVEITWDETDHERITMLNRKFKKEELLDMDFQAYL 540

Query: 541 ASSSEDEEEIEEELQGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKEND 600
           ASSSEDEEEIEEELQGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKEND
Sbjct: 541 ASSSEDEEEIEEELQGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKEND 600

Query: 601 MEMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASEEE 660
           MEMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASEEE
Sbjct: 601 MEMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASEEE 660

Query: 661 LPSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDEDSK 720
           LPSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDEDSK
Sbjct: 661 LPSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDEDSK 720

Query: 721 KHFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNF 780
           KHFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNF
Sbjct: 721 KHFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNF 780

Query: 781 KKTKAMEKILEEKARQRERKEQELTQAIKKKESEIEKESQRKSIDPALSMLIKSIKTKTE 840
           KKTKAMEKILEEKARQRERKEQELTQAIKKKESEIEKESQRKSIDPALSMLIKSIKTKTE
Sbjct: 781 KKTKAMEKILEEKARQRERKEQELTQAIKKKESEIEKESQRKSIDPALSMLIKSIKTKTE 840

Query: 841 QFQARKKQKVK 851
           QFQARKKQKVK
Sbjct: 841 QFQARKKQKVK 851


>gi|169173337 PREDICTED: similar to ABT1-associated protein [Homo
          sapiens]
          Length = 101

 Score =  176 bits (445), Expect = 1e-43
 Identities = 87/99 (87%), Positives = 91/99 (91%)

Query: 1  MSSKQEIMSDQRFRRVAKDPRFWEMPEKDRKVKIDKRFRAMFHDKKFKLNYAVDKRGRPI 60
          MSSKQEIMSDQ FR+VAKDPRFWEMPE+DRKVKI +R RAMFHDKKFKLNYAVDKRGRP 
Sbjct: 1  MSSKQEIMSDQLFRQVAKDPRFWEMPEEDRKVKIHRRCRAMFHDKKFKLNYAVDKRGRPN 60

Query: 61 SHSTTEDLKRFYDLSDSDSNLSGEDSKALSQKKIKKKKT 99
          +HSTTEDLK FYDLSDSDSNLS EDSKAL QKKIKK KT
Sbjct: 61 NHSTTEDLKHFYDLSDSDSNLSNEDSKALKQKKIKKIKT 99


>gi|169172536 PREDICTED: similar to ABT1-associated protein [Homo
          sapiens]
          Length = 101

 Score =  176 bits (445), Expect = 1e-43
 Identities = 87/99 (87%), Positives = 91/99 (91%)

Query: 1  MSSKQEIMSDQRFRRVAKDPRFWEMPEKDRKVKIDKRFRAMFHDKKFKLNYAVDKRGRPI 60
          MSSKQEIMSDQ FR+VAKDPRFWEMPE+DRKVKI +R RAMFHDKKFKLNYAVDKRGRP 
Sbjct: 1  MSSKQEIMSDQLFRQVAKDPRFWEMPEEDRKVKIHRRCRAMFHDKKFKLNYAVDKRGRPN 60

Query: 61 SHSTTEDLKRFYDLSDSDSNLSGEDSKALSQKKIKKKKT 99
          +HSTTEDLK FYDLSDSDSNLS EDSKAL QKKIKK KT
Sbjct: 61 NHSTTEDLKHFYDLSDSDSNLSNEDSKALKQKKIKKIKT 99


>gi|169173104 PREDICTED: similar to ABT1-associated protein [Homo
          sapiens]
          Length = 101

 Score =  176 bits (445), Expect = 1e-43
 Identities = 87/99 (87%), Positives = 91/99 (91%)

Query: 1  MSSKQEIMSDQRFRRVAKDPRFWEMPEKDRKVKIDKRFRAMFHDKKFKLNYAVDKRGRPI 60
          MSSKQEIMSDQ FR+VAKDPRFWEMPE+DRKVKI +R RAMFHDKKFKLNYAVDKRGRP 
Sbjct: 1  MSSKQEIMSDQLFRQVAKDPRFWEMPEEDRKVKIHRRCRAMFHDKKFKLNYAVDKRGRPN 60

Query: 61 SHSTTEDLKRFYDLSDSDSNLSGEDSKALSQKKIKKKKT 99
          +HSTTEDLK FYDLSDSDSNLS EDSKAL QKKIKK KT
Sbjct: 61 NHSTTEDLKHFYDLSDSDSNLSNEDSKALKQKKIKKIKT 99


>gi|94536805 splicing factor YT521-B isoform 2 [Homo sapiens]
          Length = 709

 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 69/302 (22%), Positives = 132/302 (43%), Gaps = 31/302 (10%)

Query: 73  DLSDSDSNLSGEDSKALSQKKIKKKKTQTKKE---IDSKNLVEKKKETKKANHKG----- 124
           +L + +S     + K   +K  + + T TK++   + S+ LV K   +  +N+K      
Sbjct: 29  ELYNPESEQDKNEKKGSKRKSDRMESTDTKRQKPSVHSRQLVSKPLSSSVSNNKRIVSTK 88

Query: 125 SENKTDLDN-----SIGIKKMKTSCKFKIDSNIS--PKKDSKEFTQKNKKEKKNIVQHTT 177
            ++ T+  N     S   K++    K ++ S+ S  P K+  E T   K++ +   +  T
Sbjct: 89  GKSATEYKNEEYQRSERNKRLDADRKIRLSSSASREPYKNQPEKTCVRKRDPERRAKSPT 148

Query: 178 DSSLEEKQRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKD 237
               E     +D   S   +S + E +    E  S  +   +  SD   N+T+ E   ++
Sbjct: 149 PDGSERIGLEVDRRASRSSQSSKEEVNS--EEYGSDHETGSSGSSDEQGNNTENE---EE 203

Query: 238 ALEEDSESVSEIGSDEESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSD 297
            +EED E   E+  D E + E+       G+++  E++EEE+E+EEE+E+ + ++ D+ +
Sbjct: 204 GVEEDVEEDEEVEEDAEEDEEVDE----DGEEEEEEEEEEEEEEEEEEEEYEQDERDQKE 259

Query: 298 SGPDLARGKGNIETSSEDEDDTADLFPEESGFEHAWRELDKDAPRADEITRRLAVCNMDW 357
            G D        +T SE  D  ++      G   +    D    +  E  R   +  + +
Sbjct: 260 EGND-------YDTRSEASDSGSESVSFTDGSVRSGSGTDGSDEKKKERKRARGISPIVF 312

Query: 358 DR 359
           DR
Sbjct: 313 DR 314



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 26/102 (25%), Positives = 54/102 (52%), Gaps = 6/102 (5%)

Query: 545 EDEEEIEEELQGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEME 604
           E++EE+EE+ + D+   V+EDG+ ++ ++++EE+  +  +      E+++K + ND +  
Sbjct: 210 EEDEEVEEDAEEDE--EVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTR 267

Query: 605 IKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKRLK 646
            +      +S  E V          +  +   EKKKE+KR +
Sbjct: 268 SE----ASDSGSESVSFTDGSVRSGSGTDGSDEKKKERKRAR 305


>gi|72534750 splicing factor YT521-B isoform 1 [Homo sapiens]
          Length = 727

 Score = 72.4 bits (176), Expect = 2e-12
 Identities = 69/302 (22%), Positives = 132/302 (43%), Gaps = 31/302 (10%)

Query: 73  DLSDSDSNLSGEDSKALSQKKIKKKKTQTKKE---IDSKNLVEKKKETKKANHKG----- 124
           +L + +S     + K   +K  + + T TK++   + S+ LV K   +  +N+K      
Sbjct: 29  ELYNPESEQDKNEKKGSKRKSDRMESTDTKRQKPSVHSRQLVSKPLSSSVSNNKRIVSTK 88

Query: 125 SENKTDLDN-----SIGIKKMKTSCKFKIDSNIS--PKKDSKEFTQKNKKEKKNIVQHTT 177
            ++ T+  N     S   K++    K ++ S+ S  P K+  E T   K++ +   +  T
Sbjct: 89  GKSATEYKNEEYQRSERNKRLDADRKIRLSSSASREPYKNQPEKTCVRKRDPERRAKSPT 148

Query: 178 DSSLEEKQRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKD 237
               E     +D   S   +S + E +    E  S  +   +  SD   N+T+ E   ++
Sbjct: 149 PDGSERIGLEVDRRASRSSQSSKEEVNS--EEYGSDHETGSSGSSDEQGNNTENE---EE 203

Query: 238 ALEEDSESVSEIGSDEESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSD 297
            +EED E   E+  D E + E+       G+++  E++EEE+E+EEE+E+ + ++ D+ +
Sbjct: 204 GVEEDVEEDEEVEEDAEEDEEVDE----DGEEEEEEEEEEEEEEEEEEEEYEQDERDQKE 259

Query: 298 SGPDLARGKGNIETSSEDEDDTADLFPEESGFEHAWRELDKDAPRADEITRRLAVCNMDW 357
            G D        +T SE  D  ++      G   +    D    +  E  R   +  + +
Sbjct: 260 EGND-------YDTRSEASDSGSESVSFTDGSVRSGSGTDGSDEKKKERKRARGISPIVF 312

Query: 358 DR 359
           DR
Sbjct: 313 DR 314



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 26/102 (25%), Positives = 54/102 (52%), Gaps = 6/102 (5%)

Query: 545 EDEEEIEEELQGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEME 604
           E++EE+EE+ + D+   V+EDG+ ++ ++++EE+  +  +      E+++K + ND +  
Sbjct: 210 EEDEEVEEDAEEDE--EVDEDGEEEEEEEEEEEEEEEEEEEEYEQDERDQKEEGNDYDTR 267

Query: 605 IKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKRLK 646
            +      +S  E V          +  +   EKKKE+KR +
Sbjct: 268 SE----ASDSGSESVSFTDGSVRSGSGTDGSDEKKKERKRAR 305


>gi|148746195 trichohyalin [Homo sapiens]
          Length = 1943

 Score = 67.8 bits (164), Expect = 4e-11
 Identities = 145/822 (17%), Positives = 334/822 (40%), Gaps = 113/822 (13%)

Query: 69   KRFYDLSDSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKN----LVEK---KKETKKAN 121
            +R   L + +  L  +  +  SQ++ + +K + + E + K     L  K   +++ +K  
Sbjct: 844  ERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQ 903

Query: 122  HKGSENKTDLDNSIGIKKMKTSCK--FKIDSNISPKKDS--KEFTQKNKKEKKNIVQHTT 177
                E + +L      K+ +   +  ++ +  +  +++   +E  +K +++++   Q+  
Sbjct: 904  QLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERER-QYRK 962

Query: 178  DSSLEEKQRTLDSGTSEIVKSPRIECSKTRRE----MQSVVQLIMTRDSDGYENSTDGEM 233
            D  L++K+  L     E  K  R E  K  RE     Q   QL+            + + 
Sbjct: 963  DKKLQQKEEQLLGEEPE--KRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQY 1020

Query: 234  CDKDALEEDSESVSEIGSD----EESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDED 289
              KD L+++ E +     +    +E E +         +++    +E E    +E E + 
Sbjct: 1021 RKKDELQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQY 1080

Query: 290  SEDDDKSDSGPDLARGKGNIETSSEDEDDTADLFPEESGFEHAWRELDKDAPRADEITRR 349
             ++++       L R +       E E    +    +   E   RE +++  R  E+ R+
Sbjct: 1081 RKEEELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLRE-EREKRRRQELERQ 1139

Query: 350  LAVCNMDWDRLKAKDLLALFNSFKPKGGVIFSVKIYPSEFGKERMKEEQVQGPVELLSIP 409
                  + + ++ ++   L    +P+       K    E  ++  +EE++Q   E L   
Sbjct: 1140 YR----EEEEVQQEEEQLLRE--EPE-------KRRRQELERQYREEEELQQEEEQLLRE 1186

Query: 410  EDAPEKDWTSREKLRDYQFKRLKYYYAVVDCDS---------PETASKIYED---CDGLE 457
            E    +    R+   + + +R K      D D          PE  + + ++   C G E
Sbjct: 1187 EQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRE 1246

Query: 458  FESSCSFIDLRFIPDDITFDDEPKDVASEVNLTAYKPKYFTSAAMGTSTVEITWDETDHE 517
             E    F  L         D + +D  S+ +L            +G         E +  
Sbjct: 1247 NEQ---FRQLE--------DSQLRDRQSQQDL---------QHLLGEQQERDR--EQERR 1284

Query: 518  RITMLNRKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKTKKSQKDDEE 577
            R    +R F +EE L+ + Q          +E ++ L+        E+ + K+ +++ + 
Sbjct: 1285 RWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQLLR--------EEREEKRRRQETDR 1336

Query: 578  QIAKYRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLE 637
            +  +  QLLQ  +E+  + +E D           ++  EE ++++ +G+  L   ++   
Sbjct: 1337 KFREEEQLLQEREEQPLRRQERD-----------RKFREEELRHQEQGRKFLEEEQRLRR 1385

Query: 638  KKKEKKRLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEE 697
            +++E+K LK +Q+   +E  E++L  D    D  F EE +Q+       +  +D    EE
Sbjct: 1386 QERERKFLKEEQQLRCQE-REQQLRQD---RDRKFREEEQQLS------RQERDRKFREE 1435

Query: 698  EIEIERQKAEMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKE----LIEDDF 753
            E ++ RQ+ E   L   E+E   +   + K  E + L +++++Q + ++E     +E++ 
Sbjct: 1436 EQQVRRQERERKFL---EEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRKFLEEEQ 1492

Query: 754  EVNVNDARFQAMYTSHLFNLDP------SDPNFKKTKAMEKILEEKARQRERKEQELTQA 807
            ++     R +      L + +P       +    + +   K L+E+ + R ++  +  + 
Sbjct: 1493 QLR-RQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQ 1551

Query: 808  IKKKESEIEKESQRKSIDPALSMLIKSIKTKTEQFQARKKQK 849
             + ++   E++ +++  +  LS   +  K + E+ + R++++
Sbjct: 1552 DRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQ 1593



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 148/887 (16%), Positives = 369/887 (41%), Gaps = 108/887 (12%)

Query: 24   EMPEKDRKVKIDKRFRA---MFHDKKFKLNYAVDKRGRPISHSTTEDLKRFYDLSDSDSN 80
            E PEK R+ + +K++R    +  +++  L    +KR R       ++ +R Y   D    
Sbjct: 976  EEPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRR-------QEWERQYRKKDE--- 1025

Query: 81   LSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANHKGSENKTDLDNSIGIKKM 140
            L  E+ + L +++ K++  + +++   +  +++++E      + +  + +L+     K+ 
Sbjct: 1026 LQQEEEQLLREEREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYR-KEE 1084

Query: 141  KTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSSLEEKQRTLDSGTSEIVKSPR 200
            +   + +      P+K  ++  ++  +E++ + Q       EE++           K  R
Sbjct: 1085 ELQQEEEQLLREEPEKRRRQERERQCREEEELQQEEEQLLREERE-----------KRRR 1133

Query: 201  IECSKTRREMQSVVQ----LIMTRDSDGYENSTDGEMCDKDALEEDSESVSEIGSD---- 252
             E  +  RE + V Q    L+            + +  +++ L+++ E +     +    
Sbjct: 1134 QELERQYREEEEVQQEEEQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQ 1193

Query: 253  -------EESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDSGPDLARG 305
                   EE E +     +   D+D   D + + E E+E+   D++   K        + 
Sbjct: 1194 ERERQYREEEELQRQKRKQRYRDEDQRSDLKWQWEPEKENAVRDNKVYCKGRENEQFRQL 1253

Query: 306  KGNIETSSEDEDDTADLFPEESGFEHA-----WRELDKDAPRADEITRRLAVCNMDWDRL 360
            + +     + + D   L  E+   +       W++ D+  P  +++ R         DR 
Sbjct: 1254 EDSQLRDRQSQQDLQHLLGEQQERDREQERRRWQQRDRHFPEEEQLEREEQKEAKRRDR- 1312

Query: 361  KAKDLLALFNSFKPKGGVIFSVKIYPSEFGKERMKEEQVQGPVELLSIPEDAP----EKD 416
            K+++   L    + +       K    E  ++  +EEQ      LL   E+ P    E+D
Sbjct: 1313 KSQEEKQLLREEREE-------KRRRQETDRKFREEEQ------LLQEREEQPLRRQERD 1359

Query: 417  WTSREKLRDYQFKRLKYYYAVVDCDSPETASKIYEDCDGLEFESSCSFIDLRFIPD-DIT 475
               RE+   +Q +  K+          E   K  ++    E +  C   + +   D D  
Sbjct: 1360 RKFREEELRHQEQGRKFLEEEQRLRRQERERKFLKE----EQQLRCQEREQQLRQDRDRK 1415

Query: 476  FDDEPKDVASEVNLTAYKPKYFTSAAMGTSTVEITWDETDHERITMLNRKFKKEE-LLDM 534
            F +E + ++ +     ++ +      +     E  + E + +     +RKF++EE LL  
Sbjct: 1416 FREEEQQLSRQERDRKFREE---EQQVRRQERERKFLEEEQQLRQERHRKFREEEQLLQE 1472

Query: 535  DFQAYLASSSEDEEEIEEELQ----GDDGVNVEEDGKTKKSQK---DDEEQIAKYRQLLQ 587
              +  L     D + +EEE Q      D    E++ ++++ ++   ++E+Q+ + ++  +
Sbjct: 1473 REEQQLHRQERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLEEEQQLHRQQRQRK 1532

Query: 588  VIQEKEK-------KGKENDMEMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKK 640
             +QE+++       + +  D + + +    L++  EE   ++ E   K    EQ + +++
Sbjct: 1533 FLQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQE 1592

Query: 641  EKKRLKRKQKALAEEASEEELPSDVDLN---DPYFAEEVKQIGINKKSVKSAKDGTSPEE 697
            ++++    ++ L  +  +++L  + D     D    +E ++  ++++     +D    EE
Sbjct: 1593 QERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQE----RDRKFLEE 1648

Query: 698  EIEIERQKAEMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKE---------- 747
            E ++ RQ+ E  L   D D   ++     +  E Q L ++++ +  +++E          
Sbjct: 1649 EPQLRRQEREQQL-RHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLRRQERER 1707

Query: 748  -LIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKARQRERKEQELTQ 806
              ++++ ++   +   +      L   +      ++ +   KILEE+  + ER+EQ+L +
Sbjct: 1708 KFLQEEQQLRRQELERKFREEEQL-RQETEQEQLRRQERYRKILEEEQLRPEREEQQLRR 1766

Query: 807  AIKKKESEIEKESQRKSIDPALSMLIKSIKTKTEQ--FQARKKQKVK 851
              + ++   E++ +++  +  L       K + E+   Q R++Q+++
Sbjct: 1767 QERDRKFREEEQLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLR 1813



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 71/336 (21%), Positives = 157/336 (46%), Gaps = 53/336 (15%)

Query: 523  NRKFKKEELLDMDFQAYLASSSEDEEEIEEE------LQGDDGVNVEEDGKTKKSQKD-- 574
            +RKF+++EL   + +       E+E+++  +      LQ +  +  +E G+ ++  +D  
Sbjct: 1500 DRKFREQELRSQEPERKFL---EEEQQLHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRK 1556

Query: 575  --DEEQIAKYRQLLQVI-QEKEKK-----GKENDMEMEIKWVPGLKESAEEMVKNKL--E 624
              +EEQ+ + R+  Q+  QE+++K      K    E E K++   ++   +  + +L  E
Sbjct: 1557 FREEEQLRQEREEQQLSRQERDRKFRLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQE 1616

Query: 625  GKDKLTPWEQFLEKKKEKK--RLKRKQKALAEEAS------EEELPSDVDLNDPYFAEEV 676
               K    EQ L++++E++  R +R +K L EE        E++L  D    D  F EE 
Sbjct: 1617 RDRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQLRRQEREQQLRHD---RDRKFREEE 1673

Query: 677  K--QIGINKKSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDEDSKKHFNYNKIVEHQNL 734
            +  Q G  ++  +  +D    EEE ++ RQ+ E   L   E++  ++     K  E + L
Sbjct: 1674 QLLQEGEEQQLRRQERDRKFREEEQQLRRQERERKFLQ--EEQQLRRQELERKFREEEQL 1731

Query: 735  SKKKKKQLMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKA 794
             ++ +++ ++++E             R++ +        +  +   ++ +   K  EE+ 
Sbjct: 1732 RQETEQEQLRRQE-------------RYRKILEEEQLRPEREEQQLRRQERDRKFREEEQ 1778

Query: 795  RQRERKEQELTQAIK----KKESEIEKESQRKSIDP 826
             ++ER+EQ+L         ++E ++ +E + + + P
Sbjct: 1779 LRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRP 1814



 Score = 53.1 bits (126), Expect = 1e-06
 Identities = 52/304 (17%), Positives = 142/304 (46%), Gaps = 23/304 (7%)

Query: 527 KKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLL 586
           ++E+L  ++ Q  L    ++EE+ ++ L+ +  +  +++ + ++ Q++  EQ  +  Q  
Sbjct: 274 EEEQLRKLERQE-LRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQE 332

Query: 587 QVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKR-- 644
           +  +++ ++ +E   E +++     +E  EE  + +L  + +    EQ L ++++ +R  
Sbjct: 333 ERREQQLRREQEERREQQLR-----REQEEERREQQLRREQEEERREQQLRREQQLRREQ 387

Query: 645 -LKRKQKALAEEA--SEEELPSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIEI 701
            L+R+Q+   E+    E++L  +  L         +Q+   ++  +  +       E  +
Sbjct: 388 QLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRL 447

Query: 702 ERQKAEMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDAR 761
           +R++ E    +  E+E  +          H+   +K++ +  +++E  E   ++   + R
Sbjct: 448 KREQEERRDWLKREEETER----------HEQERRKQQLKRDQEEERRERWLKLEEEERR 497

Query: 762 FQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKARQRERKEQELTQAIKKKESEIEKESQR 821
            Q          +  +   ++ K  E+  EE+ +QR R EQ+L +  +++  ++ K  + 
Sbjct: 498 EQQERREQQLRREQEERREQRLKRQEE--EERLQQRLRSEQQLRREQEERREQLLKREEE 555

Query: 822 KSID 825
           K ++
Sbjct: 556 KRLE 559



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 57/341 (16%), Positives = 157/341 (46%), Gaps = 25/341 (7%)

Query: 524 RKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKTKKSQKDDEEQIAKY- 582
           R+ K+++  +   + +     ++  + E  L+ ++    EE+ + ++  +++EEQ+ K  
Sbjct: 223 REEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE 282

Query: 583 -RQLLQVIQEKEKKGK--ENDMEMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKK 639
            ++L +  QE+E++ +    + ++  K     +E  EE  + +   + +    EQ L ++
Sbjct: 283 RQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQQLRRE 342

Query: 640 KEKKRLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEI 699
           +E++R ++ ++   EE  E++L  + +       EE ++  + ++     +     E+++
Sbjct: 343 QEERREQQLRREQEEERREQQLRREQE-------EERREQQLRREQQLRREQQLRREQQL 395

Query: 700 EIERQKAEMALLMMDED---------EDSKKHFNYNKIVEHQNLSKKKKKQLMKKKELIE 750
             E+Q      L  ++          E   +     +  E ++  ++++++L +++E   
Sbjct: 396 RREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQEERR 455

Query: 751 DDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKARQRERKEQELTQAIKK 810
           D  +      R +          D  +   ++   +E+  EE+  Q+ER+EQ+L    ++
Sbjct: 456 DWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEE--EERREQQERREQQLR---RE 510

Query: 811 KESEIEKESQRKSIDPALSMLIKSIKTKTEQFQARKKQKVK 851
           +E   E+  +R+  +  L   ++S +    + + R++Q +K
Sbjct: 511 QEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLK 551



 Score = 50.8 bits (120), Expect = 5e-06
 Identities = 61/304 (20%), Positives = 137/304 (45%), Gaps = 30/304 (9%)

Query: 523  NRKFKKEE-LLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKTKKSQKDDEEQIAK 581
            +RKF+++E LL    +  L     D + +EEE Q      +    + ++ + D + +  +
Sbjct: 1618 DRKFREDEQLLQEREEQQLHRQERDRKFLEEEPQ------LRRQEREQQLRHDRDRKFRE 1671

Query: 582  YRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKE 641
              QLLQ  +E++ + +E D +             EE    + E + K    EQ L +++E
Sbjct: 1672 EEQLLQEGEEQQLRRQERDRKFR----------EEEQQLRRQERERKFLQEEQQL-RRQE 1720

Query: 642  KKRLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIEI 701
             +R  R+++ L +E  +E+L            E+++     ++  +  +D    EEE ++
Sbjct: 1721 LERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEE-QL 1779

Query: 702  ERQKAEMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKK--KQLMKKKELIEDDFEVNVND 759
             +++ E  L   + D   ++     +  E Q L  +++  K   ++++L  ++ E  +  
Sbjct: 1780 RQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQRLRQ 1839

Query: 760  ARFQAMYTSHLFNLDPSDPNFKKTKAMEKIL---EEKARQRERKEQELTQAIKKKESEIE 816
             R +       F         +K++  E+ L   EE+ R++ER+ +   + I++++ E +
Sbjct: 1840 ERDRQYRAEEQFATQ------EKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEEQ 1893

Query: 817  KESQ 820
            +  Q
Sbjct: 1894 RHRQ 1897



 Score = 50.4 bits (119), Expect = 7e-06
 Identities = 56/305 (18%), Positives = 144/305 (47%), Gaps = 25/305 (8%)

Query: 545 EDEEEIEEELQGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEME 604
           E EE +E+ L+ ++   +E++ + ++  K +E +  + +QLL+  +++E++ ++   E +
Sbjct: 593 EQEERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQ 652

Query: 605 IKWVPGLK-ESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASEEELPS 663
            +    LK E  EE ++ +L+ + +    EQ L ++++++  +R +  + +   + E  +
Sbjct: 653 ERREQRLKREEEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEA 712

Query: 664 DVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDEDSKKHF 723
           D   +  Y +   KQ G  ++  +  K       E E++ Q+ E A     E+E  ++ F
Sbjct: 713 DARQSKVY-SRPRKQEGQRRRQEQEEK---RRRRESELQWQEEERAHRQQQEEEQ-RRDF 767

Query: 724 NYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKT 783
            +    E +  S++ +++L  +  L E        + R Q                 ++ 
Sbjct: 768 TWQWQAEEK--SERGRQRLSARPPLREQRERQLRAEERQQ-----------------REQ 808

Query: 784 KAMEKILEEKARQRERKEQELTQAIKKKESEIEKESQRKSIDPALSMLIKSIKTKTEQFQ 843
           + + +  E++ R+R+R+E+E      ++E ++++  + + +      L +  + +  Q Q
Sbjct: 809 RFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQ 868

Query: 844 ARKKQ 848
            R ++
Sbjct: 869 RRDQK 873



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 59/364 (16%), Positives = 161/364 (44%), Gaps = 30/364 (8%)

Query: 517 ERITMLNRKFKKEELL-----DMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKTKKS 571
           E +  L ++ ++E+ L     + + +  L  S E EE  +++L+ +     E+  K ++ 
Sbjct: 605 EEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEE 664

Query: 572 QKDDEEQIAKY----RQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKLEGKD 627
           ++  E+++ +     R+  ++ +E++++ +E       KW   L+  A+   ++K+  + 
Sbjct: 665 EERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADAR-QSKVYSRP 723

Query: 628 KLTPWEQFLEKKKEKKRLKRKQKALAEEA----SEEELPSDVDLNDPYFAEEVKQIGINK 683
           +    ++  ++++EK+R +  +    EE      ++E     D    + AEE  + G  +
Sbjct: 724 RKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQR 783

Query: 684 KSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLM 743
            S +         +    ERQ+ E   L  +E+++ ++     +  E Q L ++++ Q  
Sbjct: 784 LSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRR 843

Query: 744 KKKELI---EDDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKAM-------------E 787
           ++ + +   ED  + +    R Q       +     +   ++   +             +
Sbjct: 844 ERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEERKRRRHTLYAKPALQEQLRKEQ 903

Query: 788 KILEEKARQRERKEQELTQAIKKKESEIEKESQRKSIDPALSMLIKSIKTKTEQFQARKK 847
           ++L+E+  + +R+E+E  +  +++    E+E  ++  +  L    +  + +  + Q RK 
Sbjct: 904 QLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKD 963

Query: 848 QKVK 851
           +K++
Sbjct: 964 KKLQ 967



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 61/358 (17%), Positives = 147/358 (41%), Gaps = 28/358 (7%)

Query: 517 ERITMLNRKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKTKKSQKDDE 576
           ER+    ++ + E L   + +       E EEE  ++L   +        + ++ Q++  
Sbjct: 596 ERLEQRLKREEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLRREQQERR 655

Query: 577 EQIAKYRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKL------------- 623
           EQ  K  +  + ++++ K+  E +   E +     +E A E +K+++             
Sbjct: 656 EQRLKREEEEERLEQRLKREHEEE-RREQELAEEEQEQARERIKSRIPKWQWQLESEADA 714

Query: 624 -EGKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASEEEL--------PSDVDLNDPYFAE 674
            + K    P +Q  +++++++  KR+++    +  EEE             D    + AE
Sbjct: 715 RQSKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAE 774

Query: 675 EVKQIGINKKSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDEDSKKHFNYNKIVEHQNL 734
           E  + G  + S +         +    ERQ+ E   L  +E+++ ++     +  E Q L
Sbjct: 775 EKSERGRQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFL 834

Query: 735 SKKKKKQLMKKKELI---EDDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKAMEKILE 791
            ++++ Q  ++ + +   ED  + +    R Q       +     +   +K +      +
Sbjct: 835 EEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQKWRWQLEEE--RKRRRHTLYAK 892

Query: 792 EKARQRERKEQELTQAIKKKESEIEKESQRKSIDPALSMLIKSIKTKTEQFQARKKQK 849
              +++ RKEQ+L Q  +++    E+E +R+          + ++ + EQ    +++K
Sbjct: 893 PALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEEEQLLREEREK 950



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 56/279 (20%), Positives = 133/279 (47%), Gaps = 37/279 (13%)

Query: 545 EDEEEIEEELQGDDGVNVE-EDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEM 603
           E+EE +++ L+ +  +  E E+ + +  ++++E+++ + R+  ++ +E+E++  +     
Sbjct: 523 EEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLKREQEERRDQLLKRE 582

Query: 604 EIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASEEELPS 663
           E +    LK   EE ++ +L+ ++     E+  ++++ ++RLKR++    EE  ++ L S
Sbjct: 583 EERRQQRLKREQEERLEQRLKREEV----ERLEQEERREQRLKREEP--EEERRQQLLKS 636

Query: 664 DVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDEDSKKHF 723
           +         EE +Q  + ++  +  +     EE    E ++ E  L    E+E  ++  
Sbjct: 637 EEQ-------EERRQQQLRREQQERREQRLKREE----EEERLEQRLKREHEEERREQEL 685

Query: 724 NYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKT 783
                 E +   ++ K ++ K +  +E +      DAR   +Y         S P  ++ 
Sbjct: 686 AEE---EQEQARERIKSRIPKWQWQLESE-----ADARQSKVY---------SRPRKQEG 728

Query: 784 KAMEKILEEKARQRERKEQELTQAIKKKESEIEKESQRK 822
           +   +  EEK R+RE + Q   Q  ++   + ++E QR+
Sbjct: 729 QRRRQEQEEKRRRRESELQ--WQEEERAHRQQQEEEQRR 765



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 57/323 (17%), Positives = 152/323 (47%), Gaps = 31/323 (9%)

Query: 527 KKEELLDMDFQAYLASSSEDEE-EIEEELQGDDGVNVEEDGKTKKSQKDDEEQIA---KY 582
           ++E+LL  + +  L     ++  + E+E + D  +  EE+ + ++ +++ EE++    K 
Sbjct: 545 RREQLLKREEEKRLEQERREQRLKREQEERRDQLLKREEERRQQRLKREQEERLEQRLKR 604

Query: 583 RQLLQVIQE--KEKKGKENDMEMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKK 640
            ++ ++ QE  +E++ K  + E E +      E  EE  + +L  +++    EQ L++++
Sbjct: 605 EEVERLEQEERREQRLKREEPEEERRQQLLKSEEQEERRQQQLR-REQQERREQRLKREE 663

Query: 641 EKKRLKRKQKAL-AEEASEEELPSD--------VDLNDPYFAEEVKQIGINKKSVKSAK- 690
           E++RL+++ K    EE  E+EL  +        +    P +  +++     ++S   ++ 
Sbjct: 664 EEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRP 723

Query: 691 ---DGTSPEEEIEIERQKAEMALLMMDE--------DEDSKKHFNYNKIVEHQNLSKKKK 739
              +G    +E E +R++ E  L   +E        +E+ ++ F +    E ++   ++ 
Sbjct: 724 RKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKS---ERG 780

Query: 740 KQLMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKARQRER 799
           +Q +  +  + +  E  +     Q      L   +  +   ++ +  EK L+    + + 
Sbjct: 781 RQRLSARPPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQL 840

Query: 800 KEQELTQAIKKKESEIEKESQRK 822
           + +E  Q ++++E  ++++ +R+
Sbjct: 841 QRRERAQQLQEEEDGLQEDQERR 863



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 62/323 (19%), Positives = 136/323 (42%), Gaps = 48/323 (14%)

Query: 508  EITWDETDHERITMLNRKFKKEELLDMDFQAYLASSSED-----------EEEIEEELQG 556
            E+ W E +        ++ ++E+  D  +Q      SE             E+ E +L+ 
Sbjct: 745  ELQWQEEERAH----RQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRA 800

Query: 557  DDGVNVEEDGKTKKSQKDDEEQIAKYRQL-LQVIQEKEKKGKENDMEMEIKWVPGLKESA 615
            ++    E+    ++ +K+   +  + R+  LQ ++E+E+  +    +   +   GL+E  
Sbjct: 801  EERQQREQRFLPEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQ 860

Query: 616  EEMVKNKLEGKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASEEELPSDVDLNDPYFAEE 675
            E   +++ + +D+   W+   E+K      +R+    A+ A +E+L  +  L      EE
Sbjct: 861  ERR-RSQEQRRDQKWRWQLEEERK------RRRHTLYAKPALQEQLRKEQQL----LQEE 909

Query: 676  VKQIGINKKSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDEDSKKHFNYNKIVEHQNLS 735
             +++   ++  +  +         E ERQ  E   L  +E++  ++     +  E +   
Sbjct: 910  EEELQREEREKRRRQ---------EQERQYREEEQLQQEEEQLLREEREKRRRQERERQY 960

Query: 736  KKKKKQLMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKAR 795
            +K KK   K+++L+ ++ E      R +                 +  +  E++L E+  
Sbjct: 961  RKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEE-----------ELQQEEEQLLREERE 1009

Query: 796  QRERKEQELTQAIKKKESEIEKE 818
            +R R+E E  Q  KK E + E+E
Sbjct: 1010 KRRRQEWE-RQYRKKDELQQEEE 1031



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 58/319 (18%), Positives = 147/319 (46%), Gaps = 45/319 (14%)

Query: 547 EEEIEEELQGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGK--ENDMEME 604
           +EE +   +  D    EE G+ ++ ++ ++E     R+L +  ++ EK+ +  + D +  
Sbjct: 115 QEEDQRRFEPRDRQLEEEPGQRRRQKRQEQE-----RELAEGEEQSEKQERLEQRDRQRR 169

Query: 605 IKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKRLKRKQKA-LAEEASEEELPS 663
            + +   ++  +E  + + E +   +      E+  ++++L+R++   L  +  EE+   
Sbjct: 170 DEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQ 229

Query: 664 DVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDEDSKK-- 721
             +  D  F EE ++    +++V   ++    EEE + +R+       + +E+E  +K  
Sbjct: 230 RRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRE-------LQEEEEQLRKLE 282

Query: 722 --HFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPN 779
                  +  E Q   + +++Q +++K+  E++      + R Q                
Sbjct: 283 RQELRRERQEEEQQQQRLRREQQLRRKQ--EEERREQQEERREQQ--------------- 325

Query: 780 FKKTKAMEKILEEKAR--QRERKEQEL--TQAIKKKESEIEKESQRKSIDPAL---SMLI 832
            ++ +  E+  E++ R  Q ER+EQ+L   Q  +++E ++ +E + +  +  L     L 
Sbjct: 326 -ERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLR 384

Query: 833 KSIKTKTEQFQARKKQKVK 851
           +  + + EQ Q R++Q+++
Sbjct: 385 REQQLRREQ-QLRREQQLR 402



 Score = 36.6 bits (83), Expect = 0.10
 Identities = 39/187 (20%), Positives = 87/187 (46%), Gaps = 6/187 (3%)

Query: 522  LNRKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKTKKSQKDDEEQIAK 581
            L RKF++EE L  + +       E   +I EE Q       ++  + ++ +K  EE+   
Sbjct: 1721 LERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPEREEQQLRRQERDRKFREEE--- 1777

Query: 582  YRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKE 641
              QL Q  +E++ + +E+D +   +     +   +++   + +GK +    +  LE++++
Sbjct: 1778 --QLRQEREEQQLRSQESDRKFREEEQLRQEREEQQLRPQQRDGKYRWEEEQLQLEEQEQ 1835

Query: 642  KKRLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIEI 701
            + R +R ++  AEE    +  S  +  + +  EE K+    ++ ++        +EE + 
Sbjct: 1836 RLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQERERKLREEHIRRQQKEE-QR 1894

Query: 702  ERQKAEM 708
             RQ  E+
Sbjct: 1895 HRQVGEI 1901



 Score = 30.4 bits (67), Expect = 7.3
 Identities = 48/293 (16%), Positives = 117/293 (39%), Gaps = 39/293 (13%)

Query: 4   KQEIMSDQRFRRVAKDPRFWEMPEKDRKVKIDKRFRAMFHDKKFKLNYAVDKRGRPISHS 63
           +QE   +QR +R        E PE++R+ ++ K        ++       ++R + +   
Sbjct: 611 EQEERREQRLKR--------EEPEEERRQQLLKSEEQEERRQQQLRREQQERREQRLKRE 662

Query: 64  TTED-----LKRFYDLSDSDSNLSGEDSKALSQK---KIKKKKTQTKKEIDSKNLVEKKK 115
             E+     LKR ++    +  L+ E+ +   ++   +I K + Q + E D++   + K 
Sbjct: 663 EEEERLEQRLKREHEEERREQELAEEEQEQARERIKSRIPKWQWQLESEADAR---QSKV 719

Query: 116 ETKKANHKGSENKTDLDNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQH 175
            ++    +G   + + +            + + +S +  +++ +   Q+ ++E++     
Sbjct: 720 YSRPRKQEGQRRRQEQEEK----------RRRRESELQWQEEERAHRQQQEEEQRR--DF 767

Query: 176 TTDSSLEEKQRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCD 235
           T     EEK    + G   +   P +   + +RE Q   +    R+        + E   
Sbjct: 768 TWQWQAEEKS---ERGRQRLSARPPL---REQRERQLRAEERQQREQRFLPEEEEKEQRR 821

Query: 236 KDALEEDSESVSEIGSDEESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDE 288
           +   E + E   +   +EE         +   ++DG ++D+E    +E+  D+
Sbjct: 822 RQRREREKEL--QFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRDQ 872


>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
          Length = 793

 Score = 65.5 bits (158), Expect = 2e-10
 Identities = 93/440 (21%), Positives = 183/440 (41%), Gaps = 72/440 (16%)

Query: 392 ERMKEEQVQGPVELLSIPE-----DAPEKDWTSREKLRDYQFKRLKYYYAVVDCDSPETA 446
           ER KE         LS+P      D  E + T +E+  + + +R        + +  ET 
Sbjct: 116 ERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEKSESRQERY-------EIEETETV 168

Query: 447 SKIYEDCDGLEFESSCSFIDLRFIPDDITFDDEPKDVASEVNLTAYKPKYFTSAAMGTST 506
           +K Y+  D  + E +               +D+ K+   E      KPK     ++G + 
Sbjct: 169 TKSYQKNDWRDAEENKK-------------EDKEKEEEEEE-----KPK---RGSIGENQ 207

Query: 507 VEITWDETDHERITMLNRKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDG 566
           VE+  +E   E          +EE + M  +    SS E ++E E E QG D ++  E  
Sbjct: 208 VEVMVEEKTTE---------SQEETVVMSLKNGQISSEEPKQEEERE-QGSDEISHHEKM 257

Query: 567 KTKKSQKDDEEQI---AKYRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKL 623
           + +  ++ + E+    A+ R+ ++  Q+K+   +   +E E K     +E  E   + ++
Sbjct: 258 EEEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERM 317

Query: 624 EGKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGINK 683
             ++K    E+   K++EK+  + +Q+   EE    E    +   +   AEE ++    +
Sbjct: 318 REEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEE 377

Query: 684 KSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLM 743
                       EE+ ++E QK    L       + KKH      ++ + + +K + + +
Sbjct: 378 ------------EEKAKVEEQKRNKQL-------EEKKHAMQETKIKGEKVEQKIEGKWV 418

Query: 744 KKKELIEDDFEVNVNDARFQAMYT---SHLFNLDPSDPNFKKTKAMEKILEEKARQRERK 800
            +K+  ED  +  V   + +   T   +    L    P FKK    E+I +EK ++ +  
Sbjct: 419 NEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKK----EEIKDEKIKKDKEP 474

Query: 801 EQELTQAIKKKESEIEKESQ 820
           ++E+   + +K+   E +SQ
Sbjct: 475 KEEVKSFMDRKKGFTEVKSQ 494



 Score = 53.5 bits (127), Expect = 8e-07
 Identities = 133/702 (18%), Positives = 275/702 (39%), Gaps = 119/702 (16%)

Query: 72  YDLSDSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANHKGSEN-KTD 130
           Y  +D D     E++    +++ ++++ + K+E +S   V  + E    N    E  KT 
Sbjct: 27  YQRNDDDE----EEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTT 82

Query: 131 LDNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHT-TDSSLEEKQRTLD 189
             N+    +++   +      ++ +++ ++   +   E++     T TD+SL    R + 
Sbjct: 83  TTNT----QVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQ 138

Query: 190 SGTSEIVKSPRIECSKTRREMQSVVQ---LIMTRDSDGYENSTDGEMCDKDALEEDSES- 245
           + T+E   + + E S++R+E   + +   +  +   + + ++ + +  DK+  EE+ E  
Sbjct: 139 NDTAENETTEKEEKSESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKP 198

Query: 246 -------------VSEIGSDEESENEITSV--GRASGDDDGSEDDEEEDEDE----EEDE 286
                        V E  ++ + E  + S+  G+ S ++   E++ E+  DE    E+ E
Sbjct: 199 KRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKME 258

Query: 287 DEDSEDDD--------------KSDSGPDLARGKGNIETSSE---------DEDDTADLF 323
           +ED E  +              K++    +A  +  IE   +         + ++   + 
Sbjct: 259 EEDKERAEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERERMR 318

Query: 324 PEESGFEHAWRELDKDAPRADEITRRLAV----CNMDWDRLKAKDLLALFNSFKPKGGVI 379
            EE       + + ++  RA E  +R+         +  R+K ++  A     + +    
Sbjct: 319 EEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEE 378

Query: 380 FSVKIYPSEFGKE------RMKEEQVQGPVELLSIPEDAPEKDWTSREKLRDYQFKRLKY 433
              K+   +  K+       M+E +++G        E   E  W + +K ++ + +    
Sbjct: 379 EKAKVEEQKRNKQLEEKKHAMQETKIKGEKV-----EQKIEGKWVNEKKAQEDKLQT--- 430

Query: 434 YYAVVDCDSPETASKIYEDCDGLEFESSCSFIDLRFIPDDITFDDEPKDVASEVNLTAYK 493
             AV+     E  +K+    + L+ E   +F       + I  D EPK+   EV     +
Sbjct: 431 --AVLKKQGEEKGTKVQAKREKLQ-EDKPTFKKEEIKDEKIKKDKEPKE---EVKSFMDR 484

Query: 494 PKYFTSAAMGTSTVEITWDETDHERITMLNRKFKKEELLDMDFQAYLASSSEDEEEIEEE 553
            K FT              E   +    +  K K  E     F      +S D +E E  
Sbjct: 485 KKGFT--------------EVKSQNGEFMTHKLKHTE---NTFSRPGGRASVDTKEAEGA 527

Query: 554 LQGDDGVNVEE----DGKT------KKSQKDDE-----EQIAKYRQ-LLQVIQEKEKKGK 597
            Q + G  +EE     G+T      K  QK  E     E++ K R+   +V++E+E++ K
Sbjct: 528 PQVEAGKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRK 587

Query: 598 ENDMEMEIKWVPGLKESAEEMVKNKLEGKDK--LTPWEQFLEKKKEKKRLKRKQKALAEE 655
           + + + +++     +   EE+ + + E  +K    P +   + KK  K    K  +L  E
Sbjct: 588 QEEADRKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIE 647

Query: 656 ASEEELPSDVD----LNDPYFAEEVKQIGINKKSVKSAKDGT 693
              E L   V     +   + A  V +I    +   SA +GT
Sbjct: 648 ERAEFLNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGT 689



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 57/286 (19%), Positives = 128/286 (44%), Gaps = 33/286 (11%)

Query: 545 EDEEEIEEELQGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEME 604
           E+E+   EE Q       EE+ K K  ++   +Q+ + +  +Q   E + KG++ + ++E
Sbjct: 361 EEEKRAAEERQR---ARAEEEEKAKVEEQKRNKQLEEKKHAMQ---ETKIKGEKVEQKIE 414

Query: 605 IKWVPGLKESAEEMVKN---KLEGKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASEEEL 661
            KWV   K++ E+ ++    K +G++K T  +   EK +E K   +K++   E+  +++ 
Sbjct: 415 GKWV-NEKKAQEDKLQTAVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKE 473

Query: 662 PSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDEDSKK 721
           P           EEVK     KK     K         +++  +   +        D+K+
Sbjct: 474 PK----------EEVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRPGGRASVDTKE 523

Query: 722 HFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNFK 781
                ++   + L + +++    + E   ++FE      +  A+    L          K
Sbjct: 524 AEGAPQVEAGKRLEELRRR----RGETESEEFEKLKQKQQEAALELEELK---------K 570

Query: 782 KTKAMEKILEEKARQRERKEQELTQAIKKKESEIEKESQRKSIDPA 827
           K +   K+LEE+ ++R+++E +     ++++  +++E +R+  + A
Sbjct: 571 KREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIERRRAEAA 616



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 67/365 (18%), Positives = 150/365 (41%), Gaps = 65/365 (17%)

Query: 546 DEEEIEEEL--QGDDGVNVEEDGKTKKSQKDDEEQIAKYR------QLLQVIQEKEKKGK 597
           D+ E   EL  Q  + + +E +    +   DDEE+ A+ R      + L+  QE+E  G+
Sbjct: 2   DDFERRRELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERLRQKQEEESLGQ 61

Query: 598 END-MEMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEK--KKEKKRLKRKQKALAE 654
             D +E+  +     +E+       ++EG D+      FLE+  ++E++R KR Q+AL  
Sbjct: 62  VTDQVEVNAQNSVPDEEAKTTTTNTQVEGDDEAA----FLERLARREERRQKRLQEALER 117

Query: 655 EASEEELPSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIEIERQKAEMALLMMD 714
           +   +   +D  L+ P  +  ++      ++ +  +   S +E  EIE  +        +
Sbjct: 118 QKEFDPTITDASLSLP--SRRMQNDTAENETTEKEEKSESRQERYEIEETETVTKSYQKN 175

Query: 715 EDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKE--LIEDDFEVNVNDARFQAMYTSHLFN 772
           +  D++++   +K  E +   K K+  + + +   ++E+    +  +    ++    + +
Sbjct: 176 DWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMVEEKTTESQEETVVMSLKNGQISS 235

Query: 773 LDPSDPNFK------------------------------------KTKAMEKILEEKAR- 795
            +P     +                                    K +  +KI +E+AR 
Sbjct: 236 EEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEERERIKAEQDKKIADERARI 295

Query: 796 ---------QRERKEQELTQAIKKKESEIEKESQRKSIDPALSMLIKSIKTKTEQFQARK 846
                    +RER+E E  + ++++E    +E QR   +   +   +    + E+  A +
Sbjct: 296 EAEEKAAAQERERREAEERERMREEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEE 355

Query: 847 KQKVK 851
           +Q++K
Sbjct: 356 RQRIK 360


>gi|253970456 HIV-1 Tat specific factor 1 [Homo sapiens]
          Length = 755

 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 73/286 (25%), Positives = 120/286 (41%), Gaps = 31/286 (10%)

Query: 89  LSQKKIKKKKT-----QTKKEIDSKNLVEKKKETKKANHKGSEN---KTDLDNSIGIKKM 140
           + +KK +K +      +   E ++K    +K+  +    K SE    K   + S   K+ 
Sbjct: 426 IDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKES 485

Query: 141 KTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDS----SLEEKQRTLDSGTSEIV 196
           +     +     SPKK+SK+ T KN  E+  + + + D     S EE   T +S   +  
Sbjct: 486 EEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSE 545

Query: 197 KSPRIECSKTRREMQSVVQ-----LIMTRDSDGYENSTDGEMCDKDALEEDSESVSEIGS 251
           K    +CS+ + E  S  +     L    D +G E      + DK+  E DSE+ SE   
Sbjct: 546 KESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSEN-SEF-E 603

Query: 252 DEESENEITSVG-RASGDDDGSEDDEEEDEDE---EEDEDEDSEDDDKSDSGPDLARGKG 307
           D+ SE  +   G     D+D  E +EEED  E   +++ DE  +++   + G + A  K 
Sbjct: 604 DDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKA 663

Query: 308 N--------IETSSEDEDDTADLFPEESGFEHAWRELDKDAPRADE 345
                     E S + ED+ AD    E   E  + + D +    DE
Sbjct: 664 EEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDE 709



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 64/263 (24%), Positives = 110/263 (41%), Gaps = 40/263 (15%)

Query: 90  SQKKIKKKKTQTKKEIDSKNLVEKKKE------------TKKANHKGSENKTDLDNSIGI 137
           S KK  KKKT  K + +   L ++ ++            TK++    SE ++D D S   
Sbjct: 498 SPKKESKKKT-LKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSE-- 554

Query: 138 KKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSSLEEKQRTLDSGTSEIVK 197
           K+ +   + + + N   K   +E ++K   E  N++    + +  E     D G+ +++ 
Sbjct: 555 KQSEDGSEREFEENGLEKDLDEEGSEKELHE--NVLDKELEENDSENSEFEDDGSEKVLD 612

Query: 198 SPRIEC-----SKTRREMQSVVQLIMTRDSDG-----YENSTDGEMCDKDALEEDS-ESV 246
               E      S  + E +   + +   +SD      Y +    E  DK A E D+ E +
Sbjct: 613 EEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKL 672

Query: 247 SEIGSDEESEN----EITSVGRASGDDDGSED---DEEEDEDEEEDEDEDSEDD----DK 295
            E   D+E E+    E+        +DD S +   DEEED  E+  +D D          
Sbjct: 673 FEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDERGTLGGFGS 732

Query: 296 SDSGPDLARGKGNIETSSEDEDD 318
            + GP L+ G   I +S +D+DD
Sbjct: 733 VEEGP-LSTGSSFILSSDDDDDD 754



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 56/229 (24%), Positives = 96/229 (41%), Gaps = 29/229 (12%)

Query: 524 RKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKTKKSQKDDEEQIAKYR 583
           ++ KK+ L +   +  LA  SED+   E E +       EED   K+S +D  E+     
Sbjct: 501 KESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEK----- 555

Query: 584 QLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKEKK 643
              Q     E++ +EN +E ++      KE  E ++  +LE  D      +F +   E  
Sbjct: 556 ---QSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSEN--SEFEDDGSE-- 608

Query: 644 RLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIEIER 703
                 K L EE SE E   D D  +    E+  +   + +S +   +  + E+ +E   
Sbjct: 609 ------KVLDEEGSEREFDEDSDEKEE--EEDTYEKVFDDESDEKEDEEYADEKGLEAAD 660

Query: 704 QKAEMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKELIEDD 752
           +KAE       E +  +K F  +   E ++   K+ +   +K  L EDD
Sbjct: 661 KKAE-------EGDADEKLFEESDDKEDEDADGKEVEDADEK--LFEDD 700



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 75/378 (19%), Positives = 147/378 (38%), Gaps = 95/378 (25%)

Query: 516 HERITMLNRKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKTKKSQKDD 575
           HER+ ++   F       MDF        ED+  +  E++ D  V   + G+ +K    D
Sbjct: 262 HERVVIIKNMFHP-----MDF--------EDDPLVLNEIREDLRVECSKFGQIRKLLLFD 308

Query: 576 EEQIAKYRQLLQVIQEKEKKGKEND---MEMEIKWVPGLKESAE--------EMVKNKLE 624
                       V     +  +E D     ++ +W  G + +A+        ++ +   E
Sbjct: 309 RHPDG-------VASVSFRDPEEADYCIQTLDGRWFGGRQITAQAWDGTTDYQVEETSRE 361

Query: 625 GKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASE-------EELPSDVDLNDPYFAEEVK 677
            +++L  WE FL   +  + L+R     A E +         E PS   +N    A  + 
Sbjct: 362 REERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQETATGMA 421

Query: 678 -QIGINKKSVKSAKDG--------------TSPEEEIE--------------------IE 702
            +  I++K  +  +DG              +SPE+E E                      
Sbjct: 422 FEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCS 481

Query: 703 RQKAEMALLMMDEDEDSKKHFNYNKIVEH------------QNLSKKKKKQLMKKKELIE 750
           ++++E    +   +EDS K  +  K +++             +L+K+ ++++   KE  E
Sbjct: 482 QKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEE 541

Query: 751 DDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKARQRERKEQELTQAIKK 810
           DD E   ++        S   + D S+  F++   +EK L+E+  ++E  E  L + +++
Sbjct: 542 DDSEKESDED------CSEKQSEDGSEREFEE-NGLEKDLDEEGSEKELHENVLDKELEE 594

Query: 811 KE---SEIEKESQRKSID 825
            +   SE E +   K +D
Sbjct: 595 NDSENSEFEDDGSEKVLD 612



 Score = 32.0 bits (71), Expect = 2.5
 Identities = 34/153 (22%), Positives = 68/153 (44%), Gaps = 16/153 (10%)

Query: 516 HERITMLNRKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKTKK--SQK 573
           HE +  L+++ ++ +  + +F+   +    DEE  E E   D     EE+   +K    +
Sbjct: 584 HENV--LDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDE 641

Query: 574 DDEEQIAKYRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKLEGKDKLTPWE 633
            DE++  +Y    + ++  +KK +E D + +      L E +++      +GK+     E
Sbjct: 642 SDEKEDEEYAD-EKGLEAADKKAEEGDADEK------LFEESDDKEDEDADGKEVEDADE 694

Query: 634 QFLEKKKEKKRLKRKQKALAEEASEEELPSDVD 666
           +  E     ++L  +     EE S E+L  D D
Sbjct: 695 KLFEDDDSNEKLFDE-----EEDSSEKLFDDSD 722


>gi|21361437 HIV-1 Tat specific factor 1 [Homo sapiens]
          Length = 755

 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 73/286 (25%), Positives = 120/286 (41%), Gaps = 31/286 (10%)

Query: 89  LSQKKIKKKKT-----QTKKEIDSKNLVEKKKETKKANHKGSEN---KTDLDNSIGIKKM 140
           + +KK +K +      +   E ++K    +K+  +    K SE    K   + S   K+ 
Sbjct: 426 IDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCSQKES 485

Query: 141 KTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDS----SLEEKQRTLDSGTSEIV 196
           +     +     SPKK+SK+ T KN  E+  + + + D     S EE   T +S   +  
Sbjct: 486 EEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSE 545

Query: 197 KSPRIECSKTRREMQSVVQ-----LIMTRDSDGYENSTDGEMCDKDALEEDSESVSEIGS 251
           K    +CS+ + E  S  +     L    D +G E      + DK+  E DSE+ SE   
Sbjct: 546 KESDEDCSEKQSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSEN-SEF-E 603

Query: 252 DEESENEITSVG-RASGDDDGSEDDEEEDEDE---EEDEDEDSEDDDKSDSGPDLARGKG 307
           D+ SE  +   G     D+D  E +EEED  E   +++ DE  +++   + G + A  K 
Sbjct: 604 DDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKA 663

Query: 308 N--------IETSSEDEDDTADLFPEESGFEHAWRELDKDAPRADE 345
                     E S + ED+ AD    E   E  + + D +    DE
Sbjct: 664 EEGDADEKLFEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDE 709



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 64/263 (24%), Positives = 110/263 (41%), Gaps = 40/263 (15%)

Query: 90  SQKKIKKKKTQTKKEIDSKNLVEKKKE------------TKKANHKGSENKTDLDNSIGI 137
           S KK  KKKT  K + +   L ++ ++            TK++    SE ++D D S   
Sbjct: 498 SPKKESKKKT-LKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSE-- 554

Query: 138 KKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSSLEEKQRTLDSGTSEIVK 197
           K+ +   + + + N   K   +E ++K   E  N++    + +  E     D G+ +++ 
Sbjct: 555 KQSEDGSEREFEENGLEKDLDEEGSEKELHE--NVLDKELEENDSENSEFEDDGSEKVLD 612

Query: 198 SPRIEC-----SKTRREMQSVVQLIMTRDSDG-----YENSTDGEMCDKDALEEDS-ESV 246
               E      S  + E +   + +   +SD      Y +    E  DK A E D+ E +
Sbjct: 613 EEGSEREFDEDSDEKEEEEDTYEKVFDDESDEKEDEEYADEKGLEAADKKAEEGDADEKL 672

Query: 247 SEIGSDEESEN----EITSVGRASGDDDGSED---DEEEDEDEEEDEDEDSEDD----DK 295
            E   D+E E+    E+        +DD S +   DEEED  E+  +D D          
Sbjct: 673 FEESDDKEDEDADGKEVEDADEKLFEDDDSNEKLFDEEEDSSEKLFDDSDERGTLGGFGS 732

Query: 296 SDSGPDLARGKGNIETSSEDEDD 318
            + GP L+ G   I +S +D+DD
Sbjct: 733 VEEGP-LSTGSSFILSSDDDDDD 754



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 56/229 (24%), Positives = 96/229 (41%), Gaps = 29/229 (12%)

Query: 524 RKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKTKKSQKDDEEQIAKYR 583
           ++ KK+ L +   +  LA  SED+   E E +       EED   K+S +D  E+     
Sbjct: 501 KESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEEDDSEKESDEDCSEK----- 555

Query: 584 QLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKEKK 643
              Q     E++ +EN +E ++      KE  E ++  +LE  D      +F +   E  
Sbjct: 556 ---QSEDGSEREFEENGLEKDLDEEGSEKELHENVLDKELEENDSEN--SEFEDDGSE-- 608

Query: 644 RLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIEIER 703
                 K L EE SE E   D D  +    E+  +   + +S +   +  + E+ +E   
Sbjct: 609 ------KVLDEEGSEREFDEDSDEKEE--EEDTYEKVFDDESDEKEDEEYADEKGLEAAD 660

Query: 704 QKAEMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKELIEDD 752
           +KAE       E +  +K F  +   E ++   K+ +   +K  L EDD
Sbjct: 661 KKAE-------EGDADEKLFEESDDKEDEDADGKEVEDADEK--LFEDD 700



 Score = 40.0 bits (92), Expect = 0.009
 Identities = 75/378 (19%), Positives = 147/378 (38%), Gaps = 95/378 (25%)

Query: 516 HERITMLNRKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKTKKSQKDD 575
           HER+ ++   F       MDF        ED+  +  E++ D  V   + G+ +K    D
Sbjct: 262 HERVVIIKNMFHP-----MDF--------EDDPLVLNEIREDLRVECSKFGQIRKLLLFD 308

Query: 576 EEQIAKYRQLLQVIQEKEKKGKEND---MEMEIKWVPGLKESAE--------EMVKNKLE 624
                       V     +  +E D     ++ +W  G + +A+        ++ +   E
Sbjct: 309 RHPDG-------VASVSFRDPEEADYCIQTLDGRWFGGRQITAQAWDGTTDYQVEETSRE 361

Query: 625 GKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASE-------EELPSDVDLNDPYFAEEVK 677
            +++L  WE FL   +  + L+R     A E +         E PS   +N    A  + 
Sbjct: 362 REERLRGWEAFLNAPEANRGLRRSDSVSASERAGPSRARHFSEHPSTSKMNAQETATGMA 421

Query: 678 -QIGINKKSVKSAKDG--------------TSPEEEIE--------------------IE 702
            +  I++K  +  +DG              +SPE+E E                      
Sbjct: 422 FEEPIDEKKFEKTEDGGEFEEGASENNAKESSPEKEAEEGCPEKESEEGCPKRGFEGSCS 481

Query: 703 RQKAEMALLMMDEDEDSKKHFNYNKIVEH------------QNLSKKKKKQLMKKKELIE 750
           ++++E    +   +EDS K  +  K +++             +L+K+ ++++   KE  E
Sbjct: 482 QKESEEGNPVRGSEEDSPKKESKKKTLKNDCEENGLAKESEDDLNKESEEEVGPTKESEE 541

Query: 751 DDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKARQRERKEQELTQAIKK 810
           DD E   ++        S   + D S+  F++   +EK L+E+  ++E  E  L + +++
Sbjct: 542 DDSEKESDED------CSEKQSEDGSEREFEE-NGLEKDLDEEGSEKELHENVLDKELEE 594

Query: 811 KE---SEIEKESQRKSID 825
            +   SE E +   K +D
Sbjct: 595 NDSENSEFEDDGSEKVLD 612



 Score = 32.0 bits (71), Expect = 2.5
 Identities = 34/153 (22%), Positives = 68/153 (44%), Gaps = 16/153 (10%)

Query: 516 HERITMLNRKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKTKK--SQK 573
           HE +  L+++ ++ +  + +F+   +    DEE  E E   D     EE+   +K    +
Sbjct: 584 HENV--LDKELEENDSENSEFEDDGSEKVLDEEGSEREFDEDSDEKEEEEDTYEKVFDDE 641

Query: 574 DDEEQIAKYRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKLEGKDKLTPWE 633
            DE++  +Y    + ++  +KK +E D + +      L E +++      +GK+     E
Sbjct: 642 SDEKEDEEYAD-EKGLEAADKKAEEGDADEK------LFEESDDKEDEDADGKEVEDADE 694

Query: 634 QFLEKKKEKKRLKRKQKALAEEASEEELPSDVD 666
           +  E     ++L  +     EE S E+L  D D
Sbjct: 695 KLFEDDDSNEKLFDE-----EEDSSEKLFDDSD 722


>gi|7661950 SH2 domain binding protein 1 [Homo sapiens]
          Length = 1173

 Score = 64.7 bits (156), Expect = 3e-10
 Identities = 64/274 (23%), Positives = 110/274 (40%), Gaps = 30/274 (10%)

Query: 76   DSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANHKGSENKTDLDNSI 135
            D   N   +D   +S+KK ++K + +++E + +   E+KK+ ++ + KG E   D +   
Sbjct: 918  DEFVNDDTDDDLPISKKKKRRKGSGSEQEGEDEEGGERKKKKRRRHPKGEEGSDDDETEN 977

Query: 136  GIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSSLEEKQRTLDSGTSEI 195
            G K  K     K +   +PK +    + K K + K I+  + DSS E+K +  D G    
Sbjct: 978  GPKPKKRRPP-KAEKKKAPKPERLPPSMKGKIKSKAIISSSDDSSDEDKLKIADEG---- 1032

Query: 196  VKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDG------------EMCDKDALEEDS 243
               PR   S +  +     +   + +SD  EN                +  D+D+  +  
Sbjct: 1033 --HPRNSNSNSDSDEDEQRKKCASSESDSDENQNKSGSEAGSPRRPRRQRSDQDSDSDQP 1090

Query: 244  ESVSEIGSDEESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDSGPDLA 303
                     E+S+NE    GR+      SE+D        E + E     D   SG    
Sbjct: 1091 SRKRRPSGSEQSDNESVQSGRS--HSGVSENDSRPASPSAESDHESERGSDNEGSG---- 1144

Query: 304  RGKGNIETSSEDEDDTADLFPEESGFEHAWRELD 337
            +G GN     E E + ++    + G EH   + D
Sbjct: 1145 QGSGN-----ESEPEGSNNEASDRGSEHGSDDSD 1173


>gi|89001107 dentin sialophosphoprotein preproprotein [Homo sapiens]
          Length = 1301

 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 49/250 (19%), Positives = 91/250 (36%), Gaps = 9/250 (3%)

Query: 72  YDLSDSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANHKGSENKTDL 131
           Y+  +S  N +G DSK                + +           K  + KG  + +D 
Sbjct: 493 YNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNGNGNNGNDDNDKSDSGKGKSDSSDS 552

Query: 132 DNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSSLEEKQRTLDSG 191
           D+S       +S     DS+ S      + +  +  +  +     + +S +    +  S 
Sbjct: 553 DSSDSSNSSDSSDSSDSDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSD 612

Query: 192 TSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKDALEEDSESVSEIGS 251
           +S+   S   +   ++ E  S        DSD   +S+D    D     + S+S +   S
Sbjct: 613 SSDSSDSSDSKSDSSKSESDS-------SDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNS 665

Query: 252 DEESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDSGPDLARGKGNIET 311
            + S++  +S   +S D   S D  +  +     E  DS D   SDS    +    N  +
Sbjct: 666 SDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDSDSSD--SSDSSNSNS 723

Query: 312 SSEDEDDTAD 321
           S  D  +++D
Sbjct: 724 SDSDSSNSSD 733



 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 48/262 (18%), Positives = 98/262 (37%), Gaps = 1/262 (0%)

Query: 61  SHSTTEDLKRFYDLSDSDSNLSGEDSKALSQKKIKKKKTQT-KKEIDSKNLVEKKKETKK 119
           S S + D     D SDS  +    DS   S  K    K+++   + DSK+       +  
Sbjct: 591 SDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKSDSSDSNSSDS 650

Query: 120 ANHKGSENKTDLDNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDS 179
           +++  S + ++  NS        S      S+ S   DS + +  +   + +    ++DS
Sbjct: 651 SDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDSSDSSDSSNSSESSDSSDSSDS 710

Query: 180 SLEEKQRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKDAL 239
              +   + +S +S+   S   + S +     S      +  SD  ++S      D    
Sbjct: 711 DSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSNSSDSSDS 770

Query: 240 EEDSESVSEIGSDEESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDSG 299
            + S+S     S + +++  +S    S +   S +  +  +  +  + + S   D S+S 
Sbjct: 771 SDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSS 830

Query: 300 PDLARGKGNIETSSEDEDDTAD 321
                   +  + S D  D +D
Sbjct: 831 DSSDSSNSSDSSDSSDSSDGSD 852



 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 53/251 (21%), Positives = 86/251 (34%), Gaps = 5/251 (1%)

Query: 73  DLSDSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANHKGSENKTDLD 132
           D S S+S+ S  DSK+ S        +      DS N       +  ++   S + +D  
Sbjct: 625 DSSKSESDSSDSDSKSDSSDSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSS 684

Query: 133 NSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSSLEEKQRTLDSGT 192
           NS        S      S  S   DS +    +  +  N     +DSS         + +
Sbjct: 685 NSSDSSDSSDSSN---SSESSDSSDSSDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSS 741

Query: 193 SEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKDALEEDSESVSEIGSD 252
                S     S +     S      +  SD  ++S      D +     S+S     S 
Sbjct: 742 DSSDSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSS 801

Query: 253 EESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDS--GPDLARGKGNIE 310
           + S +  +S    S D D S   +  +  +  D    S+  D SDS  G D      +  
Sbjct: 802 DSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDSSDSSDSSDGSDSDSSNRSDS 861

Query: 311 TSSEDEDDTAD 321
           ++S D  D++D
Sbjct: 862 SNSSDSSDSSD 872



 Score = 62.0 bits (149), Expect = 2e-09
 Identities = 48/255 (18%), Positives = 84/255 (32%)

Query: 63   STTEDLKRFYDLSDSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANH 122
            S + D     D SDS  +    +S   S        + +    DS +  E    +  +N 
Sbjct: 1034 SDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSESSDSSDSSNS 1093

Query: 123  KGSENKTDLDNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSSLE 182
              S + +D  +S        S      SN S   DS + +  +     +    +++SS  
Sbjct: 1094 SDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSSDSSESSDS 1153

Query: 183  EKQRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKDALEED 242
                     +     S   + S +     S      +  SD  ++S   +  D     + 
Sbjct: 1154 SDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDS 1213

Query: 243  SESVSEIGSDEESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDSGPDL 302
            S+S     S + S++  ++    S D   S D     +  +  +  DS  D   +S    
Sbjct: 1214 SDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQS 1273

Query: 303  ARGKGNIETSSEDED 317
              G GN   S  D D
Sbjct: 1274 KSGNGNNNGSDSDSD 1288



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 52/260 (20%), Positives = 92/260 (35%), Gaps = 6/260 (2%)

Query: 63   STTEDLKRFYDLSDSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANH 122
            S + D     D S+S  + +  DS   S        + +    DS N  +    +  ++ 
Sbjct: 1010 SDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSSDS 1069

Query: 123  KGSENKTDLDNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSSLE 182
              S + +D  +S        S      S+ S   DS + +  +     +   +++DSS  
Sbjct: 1070 SDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDS 1129

Query: 183  EKQRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKDALEED 242
                     ++    S   E S +     S      +  SD  ++S      D     + 
Sbjct: 1130 SDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS 1189

Query: 243  SESVSEIGSDEESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDD-DKSDSGPD 301
            S+S     S + S++  +S    S D   S D  +  +  + +E  DS D  D SDS   
Sbjct: 1190 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDSSDSS-- 1247

Query: 302  LARGKGNIETSSEDEDDTAD 321
                  +   SS+  D T+D
Sbjct: 1248 ---NSSDSSDSSDSSDSTSD 1264



 Score = 60.8 bits (146), Expect = 5e-09
 Identities = 50/266 (18%), Positives = 92/266 (34%), Gaps = 1/266 (0%)

Query: 63   STTEDLKRFYDLSDSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANH 122
            S + D     D S+S  + +  DS   S        + +    DS +  +    +  ++ 
Sbjct: 1004 SDSSDSSDSSDSSNSSDSSNSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDS 1063

Query: 123  KGSENKTDLDNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSSLE 182
              S + +D  +S        S      SN S   DS + +  +     +    ++DSS  
Sbjct: 1064 SDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSNS 1123

Query: 183  EKQRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKDALEED 242
                     +     S   + S +     S      +  SD  ++S   +  D     + 
Sbjct: 1124 SDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDS 1183

Query: 243  SESVSEIGSDEESENEITSVGRASGDD-DGSEDDEEEDEDEEEDEDEDSEDDDKSDSGPD 301
            S+S     S + S++  +S    S D  D S+  +  D  +  D  + +E  D SDS   
Sbjct: 1184 SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDSSDSSDS 1243

Query: 302  LARGKGNIETSSEDEDDTADLFPEES 327
                  +  + S D  D+     +ES
Sbjct: 1244 SDSSNSSDSSDSSDSSDSTSDSNDES 1269



 Score = 60.1 bits (144), Expect = 9e-09
 Identities = 52/260 (20%), Positives = 90/260 (34%), Gaps = 4/260 (1%)

Query: 63   STTEDLKRFYDLSDSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANH 122
            S + D     D SDS  +  G DS + S +      + +    DS N  +    +     
Sbjct: 830  SDSSDSSNSSDSSDSSDSSDGSDSDS-SNRSDSSNSSDSSDSSDSSNSSDSSDSSDSNES 888

Query: 123  KGSENKTDLDNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSS-L 181
              S + +D  NS        S      S+ S   DS E +  +     +   +++DSS  
Sbjct: 889  SNSSDSSDSSNS-SDSDSSDSSNSSDSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDS 947

Query: 182  EEKQRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKDALEE 241
             +   + DS  S    +          +         + DS    +S+D       +   
Sbjct: 948  SDSSNSSDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSS 1007

Query: 242  DSESVSEIGSDEESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDSGPD 301
            DS   S+  +  +S N   S   +S   D S+  +  D  +  D  + S   D SDS   
Sbjct: 1008 DSSDSSDSSNSSDSSNSSDS-SNSSDSSDSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDS 1066

Query: 302  LARGKGNIETSSEDEDDTAD 321
                  +  + S D  +++D
Sbjct: 1067 SDSSDSSDSSDSSDSSESSD 1086



 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 48/247 (19%), Positives = 90/247 (36%), Gaps = 11/247 (4%)

Query: 75  SDSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANHKGSENKTDLDNS 134
           S SDS+ S  DS   S        + +    DS +  +    +  ++ K   +K++ D+S
Sbjct: 576 SSSDSDSSDSDSSDSSDSD-SSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSS 634

Query: 135 IGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSSLEEKQRTLDSGTSE 194
               K  +S     DSN S   D+ + +  +     +    ++DSS         + +  
Sbjct: 635 DSDSKSDSS-----DSNSSDSSDNSDSSDSSNSSNSSDSSDSSDSSDSSSSSDSSNSSDS 689

Query: 195 IVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKDALEEDSESVSEIGSDEE 254
              S     S++     S        DS    +S++    D D+      S S   SD  
Sbjct: 690 SDSSDSSNSSESSDSSDS-----SDSDSSDSSDSSNSNSSDSDSSNSSDSSDSSNSSDSS 744

Query: 255 SENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDSGPDLARGKGNIETSSE 314
             ++ ++   +S   D S   +  D  +  D  + S   D +DS         +  + S 
Sbjct: 745 DSSDSSNSSDSSDSSDSSNSSDSSDSSDSSDSSDSSNSSDSNDSSNSSDSSDSSNSSDSS 804

Query: 315 DEDDTAD 321
           +  D++D
Sbjct: 805 NSSDSSD 811



 Score = 58.5 bits (140), Expect = 2e-08
 Identities = 49/246 (19%), Positives = 89/246 (36%), Gaps = 6/246 (2%)

Query: 73   DLSDSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANHKGSENKTDLD 132
            D SDS  +    DS   S        + +    DS +  +    +  ++   S + +D  
Sbjct: 1062 DSSDSSDSSDSSDSSDSSDSSESSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSSDSSDSS 1121

Query: 133  NSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSSLEEKQRTLDSGT 192
            NS        S      SN S   DS E +  +     +    ++DSS  +   + DS  
Sbjct: 1122 NSSDSSDSSDSSDSSDSSNSSDSSDSSESSDSSDSSDSSDSSDSSDSS--DSSDSSDSSN 1179

Query: 193  SEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKDALEEDSESVSEIGSD 252
            S    S   + S +     S      +  SD  ++S   +  D     + S+S     S 
Sbjct: 1180 S----SDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESS 1235

Query: 253  EESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDSGPDLARGKGNIETS 312
            + S++  +S    S D   S D  +   D  ++ D  S+  + +++G D        +++
Sbjct: 1236 DSSDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSN 1295

Query: 313  SEDEDD 318
                DD
Sbjct: 1296 HSTSDD 1301



 Score = 57.0 bits (136), Expect = 7e-08
 Identities = 50/259 (19%), Positives = 100/259 (38%), Gaps = 9/259 (3%)

Query: 63   STTEDLKRFYDLSDSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANH 122
            S + D     D SDS SN S   + + S        + +    DS N  +    +  ++ 
Sbjct: 783  SDSNDSSNSSDSSDS-SNSSDSSNSSDSSDSSDSSDSDSSNSSDSSNSSDSSDSSNSSDS 841

Query: 123  KGSENKTDLDNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSSLE 182
              S + +D  +S    +  +S      S+ S   DS   +  +     N   +++DSS  
Sbjct: 842  SDSSDSSDGSDSDSSNRSDSSNS----SDSSDSSDSSNSSDSSDSSDSNESSNSSDSS-- 895

Query: 183  EKQRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKDALEED 242
            +   + DS +S+   S   + S +     S      + +S+  ++S   +  D       
Sbjct: 896  DSSNSSDSDSSDSSNSS--DSSDSSNSSDSSESSNSSDNSNSSDSSNSSDSSDSSDSSNS 953

Query: 243  SESVSEIGSDEESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDSGPDL 302
            S+S +   S   S++  ++   +S   + S+  +  D  +  D  + S   D SDS    
Sbjct: 954  SDSSNSSDSSNSSDSSDSNSSDSSDSSNSSDSSDSSDSSDSSDSSDSSNSSDSSDSSDSS 1013

Query: 303  ARGKGNIETSSEDEDDTAD 321
                 +  ++S D  +++D
Sbjct: 1014 DSSNSSDSSNSSDSSNSSD 1032



 Score = 53.9 bits (128), Expect = 6e-07
 Identities = 55/265 (20%), Positives = 93/265 (35%), Gaps = 42/265 (15%)

Query: 57  GRPISHSTTEDLKRFYDLSDSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKE 116
           G  + HS T           SDSN  G DS     K ++          D  N  ++   
Sbjct: 433 GNKVGHSNT----------GSDSNSDGYDSYDFDDKSMQG---------DDPNSSDESNG 473

Query: 117 TKKANHKGSENKTDLDNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHT 176
              AN +   N +   ++        S + K + N S  K +++    +  +  N   + 
Sbjct: 474 NDDANSESDNNSSSRGDA-----SYNSDESKDNGNGSDSKGAEDDDSDSTSDTNNSDSNG 528

Query: 177 TDSSLEEKQRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDK 236
             ++  +     DSG  +   S       +     S        DS   ++S      D 
Sbjct: 529 NGNNGNDDNDKSDSGKGKSDSSDSDSSDSSNSSDSS--------DSSDSDSSDSNSSSDS 580

Query: 237 DALEEDSESVSEIGSDEESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKS 296
           D+ + DS   S+  S + S +  +S    S D   S D  +   D  + E + S+ D KS
Sbjct: 581 DSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSKSESDSSDSDSKS 640

Query: 297 DSGPDLARGKGNIETSSEDEDDTAD 321
           DS           +++S D  D +D
Sbjct: 641 DSS----------DSNSSDSSDNSD 655



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 64/316 (20%), Positives = 110/316 (34%), Gaps = 36/316 (11%)

Query: 48  KLNYAVDKR--GRPISHSTTEDLKRFYDL-------SDSDSNLSGEDSKALSQKKIKKK- 97
           KLN+   KR   R    S T  + +  D        S  + N++ E  K    K+ K + 
Sbjct: 346 KLNHRESKRVENRITKESETHAVGKSQDKGIEIKGPSSGNRNITKEVGKGNEGKEDKGQH 405

Query: 98  -----KTQTKKEIDSKNLVEKKKETKKANHKGSENKTDLDNSIGIKKMKTSCKFKIDSNI 152
                K   K + +  N+    ++++  N  G  N     NS G         +  D   
Sbjct: 406 GMILGKGNVKTQGEVVNIEGPGQKSEPGNKVGHSNTGSDSNSDGYDS------YDFDDKS 459

Query: 153 SPKKDSKEFTQKNKKEKKNIVQHTTDSSLEE----KQRTLDSGTSEIVKSPRIECSKTRR 208
               D     + N  +  N       SS  +       + D+G     K    + S +  
Sbjct: 460 MQGDDPNSSDESNGNDDANSESDNNSSSRGDASYNSDESKDNGNGSDSKGAEDDDSDSTS 519

Query: 209 EMQSVVQLIMTRDSDGYENSTDGEMCDKDALEEDSESVSEIGSDEESENEITSVGRASGD 268
           +         T +SD   N  +G   D +   +  +  S+    + S++  +S    S D
Sbjct: 520 D---------TNNSDSNGNGNNGN--DDNDKSDSGKGKSDSSDSDSSDSSNSSDSSDSSD 568

Query: 269 DDGSEDDEEEDEDEEEDEDEDSEDDDKSDSGPDLARGKGNIETSSEDEDDTADLFPEESG 328
            D S+ +   D D  + +  DS D D SDS         +  + S D  D++D   + S 
Sbjct: 569 SDSSDSNSSSDSDSSDSDSSDSSDSDSSDSSNSSDSSDSSDSSDSSDSSDSSDSKSDSSK 628

Query: 329 FEHAWRELDKDAPRAD 344
            E    + D  +  +D
Sbjct: 629 SESDSSDSDSKSDSSD 644



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 41/141 (29%), Positives = 61/141 (43%), Gaps = 21/141 (14%)

Query: 224 GYENSTDGE--MCDKDALEED--SESVSEIGSDEES--ENEIT-SVGRASGDDD------ 270
           G  NSTD E  + +     E   SE   +I S      E E+T   G  +G D+      
Sbjct: 188 GSNNSTDNEDEIIENSCRNEGNTSEITPQINSKRNGTKEAEVTPGTGEDAGLDNSDGSPS 247

Query: 271 --GSEDDEEE----DEDEEEDEDEDSEDDDKSDSGPDLARGKGNIETSSEDEDDTADLFP 324
             G+++DE+E    DEDEE    +DS ++ K   G D   GK +   SS  ++  +  + 
Sbjct: 248 GNGADEDEDEGSGDDEDEEAGNGKDSSNNSKGQEGQD--HGKEDDHDSSIGQNSDSKEYY 305

Query: 325 EESGFEHAWRELDKDAPRADE 345
           +  G E    E+D D     E
Sbjct: 306 DPEGKEDPHNEVDGDKTSKSE 326



 Score = 35.8 bits (81), Expect = 0.17
 Identities = 42/156 (26%), Positives = 70/156 (44%), Gaps = 20/156 (12%)

Query: 178 DSSLEEKQRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENST-----DGE 232
           D  +E   R  +  TSEI  +P+I   +   +   V     T +  G +NS      +G 
Sbjct: 197 DEIIENSCRN-EGNTSEI--TPQINSKRNGTKEAEVTP--GTGEDAGLDNSDGSPSGNGA 251

Query: 233 MCDKDALEEDSESVSEIGSDEESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSED 292
             D+D    D E   E G+ ++S N   S G+  G D G EDD +    +  D  E  + 
Sbjct: 252 DEDEDEGSGDDED-EEAGNGKDSSN--NSKGQ-EGQDHGKEDDHDSSIGQNSDSKEYYDP 307

Query: 293 DDKSDSGPDLARGKGNIETSSEDEDDTADLFPEESG 328
           + K D   ++   K     +S+ E+++A + PE++G
Sbjct: 308 EGKEDPHNEVDGDK-----TSKSEENSAGI-PEDNG 337



 Score = 30.4 bits (67), Expect = 7.3
 Identities = 24/118 (20%), Positives = 38/118 (32%)

Query: 63   STTEDLKRFYDLSDSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANH 122
            S + D     D SDS  +    DS   S        + +    DS +  +     + ++ 
Sbjct: 1178 SNSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSSDSNESSDS 1237

Query: 123  KGSENKTDLDNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSS 180
              S + +D  NS        S     DSN      SK     N     +     +DS+
Sbjct: 1238 SDSSDSSDSSNSSDSSDSSDSSDSTSDSNDESDSQSKSGNGNNNGSDSDSDSEGSDSN 1295


>gi|84043963 eukaryotic translation initiation factor 5B [Homo
           sapiens]
          Length = 1220

 Score = 63.9 bits (154), Expect = 6e-10
 Identities = 68/332 (20%), Positives = 134/332 (40%), Gaps = 31/332 (9%)

Query: 17  AKDPRFWEMPEKDRKVKIDKRFRAMFHDKKFKLNYAVDKRGRPISHSTTEDLKRFYDLSD 76
           A+D    +  +KD+K K  ++       KK      V      ++    E+ ++  +  +
Sbjct: 305 AEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEE 364

Query: 77  SDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANHKGSENKTDLDNSIG 136
               L   ++K   +++++++K + KK+ + +     KKE K       E +   + ++ 
Sbjct: 365 RIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATL- 423

Query: 137 IKKMKTSCKFKIDSNIS-PKKDSKEFTQKNKKEKKNIVQHTTDSSLE--EKQRTLDSGTS 193
             K+  +   ++ S  S PKK      +K KK  + +       S+E       ++ G  
Sbjct: 424 --KLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVP 481

Query: 194 EIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKDALEEDSESVSEIGSDE 253
           E  ++P                     + +  E++ D  + D +A+  D E+    G+  
Sbjct: 482 EKEETPP------------------PVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKV 523

Query: 254 ESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDD-------DKSDSGPDLARGK 306
             E +         +++  ED+E E+E+EEE E E SE D       D+ DSG  L +  
Sbjct: 524 HIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKP 583

Query: 307 GNIETSSEDEDDTADLFPEESGFEHAWRELDK 338
               +S  + D   D   EE  ++ A R ++K
Sbjct: 584 SKEMSSDSEYDSDDDRTKEERAYDKAKRRIEK 615



 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 82/373 (21%), Positives = 143/373 (38%), Gaps = 63/373 (16%)

Query: 15  RVAKDPRFWEMPEKDRKVKIDKRFRAMFHDKKFKLNYAVDKRGRPISHSTTEDLKRFYDL 74
           R  K+    E  +KD+  +  K  +  F ++  K    VD    P S    E        
Sbjct: 251 RKLKEKEELETGKKDQSKQ--KESQRKFEEETVKSKVTVDTGVIPASEEKAE-------- 300

Query: 75  SDSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANHKG-SENKTDLDN 133
               +  + ED     +KK  KKK + +KE   K   EKKK   KA  K   E    L  
Sbjct: 301 ----TPTAAEDDNEGDKKKKDKKKKKGEKEEKEK---EKKKGPSKATVKAMQEALAKLKE 353

Query: 134 SIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSSLEEKQRTLDSGTS 193
               +K +   + K    +  K+  +E  ++ K+E+K   +      L+++ + L     
Sbjct: 354 EEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQR 413

Query: 194 EIVKSPRIECSKTRREMQSVVQLIMTRDS--------------------DGYENSTDGEM 233
           E     R     T + +Q+    + ++DS                    +  E S   E+
Sbjct: 414 EA----RARAEATLKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMEL 469

Query: 234 CD-----KDALEEDSESVSEIGSDEESENEITSVG--RASGDDDGSED------------ 274
           C      +  + E  E+   +  +EE + E   +    A   D+ +E             
Sbjct: 470 CAAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKE 529

Query: 275 --DEEEDEDEEEDEDEDSEDDDKSDSGPDLARGKGNIETSSEDEDDTADLFPEESGFEHA 332
             +EEE+E+EEE+EDE+SE++++ +   + + G    E  S+++D    L  + S    +
Sbjct: 530 NPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSS 589

Query: 333 WRELDKDAPRADE 345
             E D D  R  E
Sbjct: 590 DSEYDSDDDRTKE 602



 Score = 50.1 bits (118), Expect = 9e-06
 Identities = 68/322 (21%), Positives = 143/322 (44%), Gaps = 28/322 (8%)

Query: 508 EITWDETDHERITMLNRKFKKEELLD-MDFQAYLASSSEDEEEIEEELQGD-DGVNVEED 565
           E+   + D  +     RKF++E +   +     +  +SE++ E     + D +G   ++D
Sbjct: 258 ELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKD 317

Query: 566 GKTKKSQKDDEEQIAKY---RQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNK 622
            K KK +K+++E+  K    +  ++ +QE   K KE +   + +    +K   E   K K
Sbjct: 318 KKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRK 377

Query: 623 LEGKDKLTPWEQFLEKKKEKK-RLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGI 681
            E + +    E+  +K+KE+K RLK++ K L +   E    ++  L      + ++  G+
Sbjct: 378 EEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATL------KLLQAQGV 431

Query: 682 NKKSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQ 741
              S    KD    +  I  ++++ ++   +  ++            V  Q + +K++  
Sbjct: 432 EVPS----KDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETP 487

Query: 742 LMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKARQRERKE 801
              + E  ED  +  ++D  ++AM          SD   +K +  +  +E K    E +E
Sbjct: 488 PPVEPEEEEDTEDAGLDD--WEAM---------ASDEETEKVEGNKVHIEVKENPEEEEE 536

Query: 802 QELTQAIKKKESEIEKESQRKS 823
           +E  +  + +ESE E+E + +S
Sbjct: 537 EE-EEEEEDEESEEEEEEEGES 557



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 118/589 (20%), Positives = 223/589 (37%), Gaps = 100/589 (16%)

Query: 76  DSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETK----------------- 118
           +++   + +D K    KK +K K Q+  + DS+ L +K  ++K                 
Sbjct: 86  NNEEEFTSKDKK----KKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGSDDDD 141

Query: 119 --------------KANHKGSENKTDLDNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQK 164
                         K+N K   ++ D DNS  IK+     + +I+S+     +S EF Q 
Sbjct: 142 DFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKE-----RSRINSSGESGDESDEFLQS 196

Query: 165 NKKEKKNIVQH---TTDSSLEEKQRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRD 221
            K +KKN         +S  E+   +    T    K+ + E  + +R+ +   +L   ++
Sbjct: 197 RKGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRD-EEKAKLRKLKE 255

Query: 222 SDGYENSTDGEMCDKDAL----EEDSESVSEIGSDEESENEITSVGRASGDDDGSEDDEE 277
            +  E     +   K++     EE  +S   + +     +E  +    + +DD   D ++
Sbjct: 256 KEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKK 315

Query: 278 EDEDEEEDEDEDSEDDDKSDSGPDLARGKGNIETSSEDEDDTADLFPEESGFEHAWRELD 337
           +D+ +++ E E+ E + K   GP  A  K   E  ++ +++      EE   E   R  +
Sbjct: 316 KDKKKKKGEKEEKEKEKK--KGPSKATVKAMQEALAKLKEEEERQKREEE--ERIKRLEE 371

Query: 338 KDAPRADEITRRLAVCNMDWDRLKAKDLLALFNSFKPKGGVIFSVKIYPSEFGKERMKEE 397
            +A R +E   RL     +  + K K+        K +G ++   +       +  +K  
Sbjct: 372 LEAKRKEE--ERLEQEKRERKKQKEKERK---ERLKKEGKLLTKSQREARARAEATLKLL 426

Query: 398 QVQGPVELLSIPEDAPEKDWTSREKLRDYQFKRLKYYYAVVDCDSPETASKIYEDCDGLE 457
           Q QG         + P KD +  +K   Y+ K+ K               KI +  +  E
Sbjct: 427 QAQG--------VEVPSKD-SLPKKRPIYEDKKRK---------------KIPQQLESKE 462

Query: 458 FESSCSFIDLRFIPDDITFDDEPKDVASEVNLTAYKPKYFTSAAMGTSTVEITWDE-TDH 516
              S                      A EV       K  T   +     E T D   D 
Sbjct: 463 VSESMELC-----------------AAVEVMEQGVPEKEETPPPVEPEEEEDTEDAGLDD 505

Query: 517 ERITMLNRKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKTKKSQKDDE 576
                 + + +K E   +  +       E+EEE EEE   +     EE+G+++ S+ D+E
Sbjct: 506 WEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGESEGSEGDEE 565

Query: 577 -EQIAKYRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKLE 624
            E+++  +   + + +K  K   +D E +       +E A +  K ++E
Sbjct: 566 DEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKRRIE 614



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 129/708 (18%), Positives = 262/708 (37%), Gaps = 109/708 (15%)

Query: 102 KKEIDSKNLVEKKKETKKANHKGSENKTDLDN----SIGIKKMKTSCKFKIDSNISPKKD 157
           K++   K+  +KKKE KK +    +   +L+     + GIK  + +   K   N   +  
Sbjct: 33  KEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVAVKPTENNEEEFT 92

Query: 158 SKEFTQKNKKEKKNIVQHTTDSSLEEKQRTLDSGTSEIVKSPRIECSKTRREMQSVVQLI 217
           SK+  +K +K KK          LE+K                   SK+++  +  V++ 
Sbjct: 93  SKDKKKKGQKGKKQSFDDNDSEELEDKD------------------SKSKKTAKPKVEMY 134

Query: 218 MTRDSDGYENSTDGEMCDKDALEEDSESVSEIGSDEESENEITSVGRASGDDDGSEDDEE 277
              D D      D     K A  +  +S  +    EE E+    +   S  +   E  +E
Sbjct: 135 SGSDDD-----DDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDE 189

Query: 278 EDEDEEEDEDEDSEDDDKSDSGPDLARGKGNIETSSEDEDDTADL----FPEESGFEHAW 333
            DE  +  + +  + + K+  GP       NIE+ +ED+D +  +      +    E   
Sbjct: 190 SDEFLQSRKGQ--KKNQKNKPGP-------NIESGNEDDDASFKIKTVAQKKAEKKERER 240

Query: 334 RELDKDAPRADEITRRLAVCNMDWDRLKAKDLLALFNSFKPKGGVIFSVKIYPSEFGKER 393
           ++ D++  +  ++  +  +     D+ K K+    F     K  V     + P+      
Sbjct: 241 KKRDEEKAKLRKLKEKEELETGKKDQSKQKESQRKFEEETVKSKVTVDTGVIPA------ 294

Query: 394 MKEEQVQGPVELLSIPEDAPEKDWTSREKLRDYQFKRLKYYYAVVDCDSPETASKIYEDC 453
             EE+ + P         A E D    +K +D + K+                 K  ++ 
Sbjct: 295 -SEEKAETPT--------AAEDDNEGDKKKKDKKKKK---------------GEKEEKEK 330

Query: 454 DGLEFESSCSFIDLRFIPDDITFDDEPKDVASEVNLTAYKPKYFTSAAMGTSTVEITWDE 513
           +  +  S  +   ++     +  ++E +    E  +   +              E+    
Sbjct: 331 EKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLE--------------ELEAKR 376

Query: 514 TDHERITMLNRKFKKE------ELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGK 567
            + ER+    R+ KK+      E L  + +    S  E     E  L+      VE   K
Sbjct: 377 KEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVEVPSK 436

Query: 568 TKKSQKDDEEQIAKYRQLLQVIQEKE-KKGKENDMEMEI--KWVPGLKESAEEMVKNKLE 624
               +K    +  K +++ Q ++ KE  +  E    +E+  + VP  +E+   +   + E
Sbjct: 437 DSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEPEEEE 496

Query: 625 GKDK--LTPWEQFL-EKKKEKKRLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGI 681
             +   L  WE    +++ EK    +    + E   EEE   + +  D    EE ++ G 
Sbjct: 497 DTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEEEEEEEEDEESEEEEEEEGE 556

Query: 682 NKKSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQ 741
           ++ S     +G   +E++  E+   +       ++  S   ++ +     +  +  K K+
Sbjct: 557 SEGS-----EGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDSDDDRTKEERAYDKAKR 611

Query: 742 LMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKAMEKI 789
            ++K+ L   +   NVN  + +A     L ++D       KTK ++K+
Sbjct: 612 RIEKRRL---EHSKNVNTEKLRAPIICVLGHVDTG-----KTKILDKL 651



 Score = 48.1 bits (113), Expect = 3e-05
 Identities = 65/300 (21%), Positives = 133/300 (44%), Gaps = 42/300 (14%)

Query: 550 IEEELQGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEMEIKWVP 609
           IE   + DD     +    KK++K + E+  +  +  ++ + KEK+  E   + + K   
Sbjct: 212 IESGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKE 271

Query: 610 GLKESAEEMVKNKL--------EGKDKL-TPWEQFLEKKKEKKRLKRKQKALAEEASEEE 660
             ++  EE VK+K+          ++K  TP     + + +KK+  +K+K   +E  E+E
Sbjct: 272 SQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKE 331

Query: 661 LPSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSP-EEEIEIERQKAEMALLMMDEDEDS 719
                           K+ G +K +VK+ ++  +  +EE E ++++ E  +  ++E E  
Sbjct: 332 ----------------KKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAK 375

Query: 720 KKHFNYNKIVEHQNLSKKKKKQLMKKKELIEDD--FEVNVNDARFQAMYTSHLFNLD--- 774
           +K     + +E +   +KK+K+  +K+ L ++      +  +AR +A  T  L       
Sbjct: 376 RKE---EERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEATLKLLQAQGVE 432

Query: 775 -PSDPNFKK------TKAMEKILEEKARQRERKEQELTQAIKKKESEI-EKESQRKSIDP 826
            PS  +  K       K  +KI ++   +   +  EL  A++  E  + EKE     ++P
Sbjct: 433 VPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPEKEETPPPVEP 492



 Score = 47.8 bits (112), Expect = 4e-05
 Identities = 78/344 (22%), Positives = 148/344 (43%), Gaps = 50/344 (14%)

Query: 506 TVEITWDETDHERITMLNRKFK-----KEELLDMDFQAYLASSSEDEEEIEEELQGDDGV 560
           TV +   E + E  T  ++K K     K+   D D +      S+ ++  + +++   G 
Sbjct: 78  TVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSEELEDKDSKSKKTAKPKVEMYSGS 137

Query: 561 NVEED---------GKTKKSQK------DDEEQIAKYRQLLQVIQEKEKKGKENDMEMEI 605
           + ++D         GK +KS K      +DE+   K ++  ++    E  G E+D  ++ 
Sbjct: 138 DDDDDFNKLPKKAKGKAQKSNKKWDGSEEDEDNSKKIKERSRINSSGES-GDESDEFLQS 196

Query: 606 KWVPGLKESAEEM----VKNKLEGKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASEEEL 661
           +   G K++ +      +++  E  D     +   +KK EKK  +RK++   E+A   +L
Sbjct: 197 R--KGQKKNQKNKPGPNIESGNEDDDASFKIKTVAQKKAEKKERERKKRD-EEKAKLRKL 253

Query: 662 PSDVDLND---PYFAEEVKQIGINKKSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDED 718
               +L         ++  Q    +++VKS    T     I    +KAE      D++E 
Sbjct: 254 KEKEELETGKKDQSKQKESQRKFEEETVKSKV--TVDTGVIPASEEKAETPTAAEDDNEG 311

Query: 719 SKKHFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSDP 778
            KK              KK KK+   +KE  E + +   + A  +AM  + L  L   + 
Sbjct: 312 DKK--------------KKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEA-LAKLKEEEE 356

Query: 779 NFKKTKAMEKILEEKARQRERKEQELTQAIKKKESEIEKESQRK 822
             K+ +  E+I   +  + +RKE+E  +  +K+E + +KE +RK
Sbjct: 357 RQKREEE-ERIKRLEELEAKRKEEERLEQ-EKRERKKQKEKERK 398



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 71/304 (23%), Positives = 117/304 (38%), Gaps = 73/304 (24%)

Query: 546 DEEEIEEELQGDDGVNVEEDGKTK-KSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEME 604
           D + +  E++G      +E  K+K K +K+ ++Q      +L+ ++E   + +       
Sbjct: 18  DLDALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQ------- 70

Query: 605 IKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASEE----- 659
                G+K   E +     E  +     E+F  K K+KK  K K+++  +  SEE     
Sbjct: 71  -----GIKADRETVAVKPTENNE-----EEFTSKDKKKKGQKGKKQSFDDNDSEELEDKD 120

Query: 660 -----------ELPSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIEIERQKAEM 708
                      E+ S  D +D +     K  G  +KS K   DG S E+E   ++ K   
Sbjct: 121 SKSKKTAKPKVEMYSGSDDDDDFNKLPKKAKGKAQKSNKKW-DG-SEEDEDNSKKIKERS 178

Query: 709 ALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQAMYTS 768
            +    E  D    F        Q+   +KK Q  K    IE   E              
Sbjct: 179 RINSSGESGDESDEFL-------QSRKGQKKNQKNKPGPNIESGNE-------------- 217

Query: 769 HLFNLDPSDPNFKKTKAMEKILEEKARQRERKEQELTQAIKKKESE----------IEKE 818
                   D +FK     +K  E+K R+R+++++E  +  K KE E           +KE
Sbjct: 218 ------DDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKE 271

Query: 819 SQRK 822
           SQRK
Sbjct: 272 SQRK 275


>gi|24415404 MDN1, midasin homolog [Homo sapiens]
          Length = 5596

 Score = 62.8 bits (151), Expect = 1e-09
 Identities = 68/294 (23%), Positives = 119/294 (40%), Gaps = 40/294 (13%)

Query: 76   DSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANHKGSENKTDLDNSI 135
            DS S++ GED+             +  ++ D K    + +E ++ + K      DLD  +
Sbjct: 4715 DSKSDIKGEDNAI-----------EMSEDFDGKMHDGELEEQEEDDEKSDSEGGDLDKHM 4763

Query: 136  GIKKMKTSCKFKIDSNISPKKDSKEFTQK--NKKEKKNIVQHTTDSSLEEKQRTLDSGTS 193
            G   +      K+D  +    D +E  ++  NK E+        DS L  K   LDSG S
Sbjct: 4764 G--DLNGEEADKLDERLWGDDDEEEDEEEEDNKTEETGPGMDEEDSELVAKDDNLDSGNS 4821

Query: 194  EIVKSPR--------IECSKTRREMQSVVQLIMTRDSDGYENSTDG-------------- 231
               KS +         E     +    + + I  RD D  EN  D               
Sbjct: 4822 NKDKSQQDKKEEKEEAEADDGGQGEDKINEQIDERDYD--ENEVDPYHGNQEKVPEPEAL 4879

Query: 232  EMCDKDALEEDSESVSEIGSDEESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSE 291
            ++ D   L+ + ++  E   +EE E E     +   ++ G E +E  + + +++E +  +
Sbjct: 4880 DLPDDLNLDSEDKNGGEDTDNEEGEEENPLEIKEKPEEAGHEAEERGETETDQNESQSPQ 4939

Query: 292  DDDKSDSGPDLARGKGNIETSSEDEDDTADLFPEESGFEHAWRELDKDAPRADE 345
            + ++  S  D A G+  ++T ++D+D  A   PEE   E      +KD   ADE
Sbjct: 4940 EPEEGPSEDDKAEGEEEMDTGADDQDGDAAQHPEEHSEEQQQSVEEKD-KEADE 4992



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 111/549 (20%), Positives = 198/549 (36%), Gaps = 88/549 (16%)

Query: 73   DLSDSDSNL-SGEDSKALSQKKIKKKKTQTK------------KEIDSKNLVEKKKETKK 119
            +L   D NL SG  +K  SQ+  K++K + +            ++ID ++  E + +   
Sbjct: 4808 ELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEADDGGQGEDKINEQIDERDYDENEVDPYH 4867

Query: 120  ANHKG--SENKTDLDNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTT 177
             N +        DL + + +           D N     D++E  ++N  E K   +   
Sbjct: 4868 GNQEKVPEPEALDLPDDLNLDSE--------DKNGGEDTDNEEGEEENPLEIKEKPEEAG 4919

Query: 178  DSSLEEKQRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKD 237
              + E  +   D   S+  + P    S+  +            D DG     D     ++
Sbjct: 4920 HEAEERGETETDQNESQSPQEPEEGPSEDDKAEGEEEMDTGADDQDG-----DAAQHPEE 4974

Query: 238  ALEEDSESVSEIGSDEESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSD 297
              EE  +SV E   D+E++ E    G A       E++E ED D EE   E  E  + + 
Sbjct: 4975 HSEEQQQSVEE--KDKEADEEGGENGPADQGFQPQEEEEREDSDTEEQVPEALERKEHAS 5032

Query: 298  SGPDLARGKGNIETSSEDEDDTADLFPEESGFEHAWRELDKDAPRADEITRRLAVCNMDW 357
             G     G  N++ +   E   A    E+   EH     D +     E      + +   
Sbjct: 5033 CG---QTGVENMQNTQAMELAGAAPEKEQGKEEHGSGAADANQAEGHESNFIAQLASQKH 5089

Query: 358  DRLKAKDLLALFNSFKPKGGVIFSVKIYPSEFGKERMKEEQVQGPVELLSIPEDAPEKDW 417
             R   +       SFK K G   + +      G    +  +    V+  S  E  P +  
Sbjct: 5090 TRKNTQ-------SFKRKPGQADNER----SMGDHNERVHKRLRTVDTDSHAEQGPAQQP 5138

Query: 418  TSREKLRDYQFKRLKYYYAVVDCDSPETASKIYEDC---DGLEFESSCSFIDLRFIPDDI 474
             ++ +  D  F+ +K      D  + + ASK  +      G + E            +D 
Sbjct: 5139 QAQVEDAD-AFEHIKQGSDAYDAQTYDVASKEQQQSAKDSGKDQEEE--------EIEDT 5189

Query: 475  TFDDEPKDVASEVNLTAYKP---KYFTSAAMG--TSTVEITWDETDHERITMLNRKFKKE 529
              D E ++     ++   KP   K  T+A +G     VEI   +T+ ++    ++  K+ 
Sbjct: 5190 LMDTEEQEEFKAADVEQLKPEEIKSGTTAPLGFDEMEVEIQTVKTEEDQDPRTDKAHKET 5249

Query: 530  E------------------LLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKTKKS 571
            E                  L+D  FQ +L   +E  +E+E +L         E  + ++S
Sbjct: 5250 ENEKPERSRESTIHTAHQFLMDTIFQPFLKDVNELRQELERQL---------EMWQPRES 5300

Query: 572  QKDDEEQIA 580
               +EE++A
Sbjct: 5301 GNPEEEKVA 5309



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 133/664 (20%), Positives = 249/664 (37%), Gaps = 138/664 (20%)

Query: 232  EMCDKDALEEDSESVSEIGSDEESENEITSVGRASGDDDGSEDDEEEDEDEEEDE-DEDS 290
            ++ D+   EE  E   + G +++ E+   S     G+D+  E  E+ D    + E +E  
Sbjct: 4688 DVSDQIGNEEQVEDTFQKGQEKDKEDP-DSKSDIKGEDNAIEMSEDFDGKMHDGELEEQE 4746

Query: 291  EDDDKSDS-GPDLARGKGNIETSSEDEDDTADLFPEESGFEHAWRELDKDAPRADEITRR 349
            EDD+KSDS G DL +  G++     D+ D           E  W + D++    +E  + 
Sbjct: 4747 EDDEKSDSEGGDLDKHMGDLNGEEADKLD-----------ERLWGDDDEEEDEEEEDNKT 4795

Query: 350  ----LAVCNMDWDRLKAKDLLALFNSFKPKGGVIFSVKIYPSEFGKERMKEEQVQGPVEL 405
                  +   D + +   D L   NS K K           S+  K+  KEE        
Sbjct: 4796 EETGPGMDEEDSELVAKDDNLDSGNSNKDK-----------SQQDKKEEKEE-------- 4836

Query: 406  LSIPEDAPEKDWTSREKL--RDYQFKRLKYYYAVVDCDSPETASKIYEDCDGLEFESSCS 463
             +  +D  + +    E++  RDY    +  Y+            K+ E  + L+      
Sbjct: 4837 -AEADDGGQGEDKINEQIDERDYDENEVDPYHG--------NQEKVPEP-EALD------ 4880

Query: 464  FIDLRFIPDDITFDDEPK--------DVASEVNLTAYKPKYFTSAAMGTSTVEITWDETD 515
                  +PDD+  D E K        +   E N    K K       G    E    ETD
Sbjct: 4881 ------LPDDLNLDSEDKNGGEDTDNEEGEEENPLEIKEK---PEEAGHEAEERGETETD 4931

Query: 516  HERITMLNRKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKTKKSQKDD 575
                   N     +E  +         S +D+ E EEE+  D G + ++    +  ++  
Sbjct: 4932 Q------NESQSPQEPEE-------GPSEDDKAEGEEEM--DTGADDQDGDAAQHPEEHS 4976

Query: 576  EEQIAKYRQLLQVIQEKEKKGKENDME---MEIKWVPGLKE-----SAEEMVKNKLEGKD 627
            EEQ        Q ++EK+K+  E   E    +  + P  +E       EE V   LE K+
Sbjct: 4977 EEQ-------QQSVEEKDKEADEEGGENGPADQGFQPQEEEEREDSDTEEQVPEALERKE 5029

Query: 628  KLTPWEQFLEKKKEKKRLKRKQKALAEEASEEELPS---DVDLNDPYFAEEVKQIGINKK 684
              +  +  +E  +  + ++    A  +E  +EE  S   D +  + + +  + Q+   K 
Sbjct: 5030 HASCGQTGVENMQNTQAMELAGAAPEKEQGKEEHGSGAADANQAEGHESNFIAQLASQKH 5089

Query: 685  SVKSAKDGTSPEEEIEIER------QKAEMALLMMD-----------------EDEDSKK 721
            + K+ +       + + ER      ++    L  +D                 ED D+ +
Sbjct: 5090 TRKNTQSFKRKPGQADNERSMGDHNERVHKRLRTVDTDSHAEQGPAQQPQAQVEDADAFE 5149

Query: 722  HFNYNK---IVEHQNLSKKKKKQLMKK--KELIEDDFEVNVNDARFQAMY-TSHLFNLDP 775
            H          +  +++ K+++Q  K   K+  E++ E  + D   Q  +  + +  L P
Sbjct: 5150 HIKQGSDAYDAQTYDVASKEQQQSAKDSGKDQEEEEIEDTLMDTEEQEEFKAADVEQLKP 5209

Query: 776  SDPNFKKTKAM----EKILEEKARQRERKEQELTQAIKKKESEIEKESQRKSIDPALSML 831
             +     T  +     ++  +  +  E ++    +A K+ E+E  + S+  +I  A   L
Sbjct: 5210 EEIKSGTTAPLGFDEMEVEIQTVKTEEDQDPRTDKAHKETENEKPERSRESTIHTAHQFL 5269

Query: 832  IKSI 835
            + +I
Sbjct: 5270 MDTI 5273



 Score = 34.7 bits (78), Expect = 0.38
 Identities = 65/356 (18%), Positives = 139/356 (39%), Gaps = 50/356 (14%)

Query: 494  PKYFTSAAMGTSTVEITWDET----DHERITMLNRKFKKEELLDMDFQAYLASSSEDEEE 549
            PK F   + G    E    E     + E +  ++ +   EE ++  FQ       ED + 
Sbjct: 4657 PKEFMEDSAGEGATEFHDYEGGGIGEGEGMKDVSDQIGNEEQVEDTFQKGQEKDKEDPDS 4716

Query: 550  IEEELQGDDGVNVEE-------DGKTKKSQKDDE------------------EQIAKYRQ 584
              +    D+ + + E       DG+ ++ ++DDE                  E+  K  +
Sbjct: 4717 KSDIKGEDNAIEMSEDFDGKMHDGELEEQEEDDEKSDSEGGDLDKHMGDLNGEEADKLDE 4776

Query: 585  LLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKR 644
             L    ++E+  +E D + E +  PG+ E   E+V       D L       +K ++ K+
Sbjct: 4777 RLWGDDDEEEDEEEEDNKTE-ETGPGMDEEDSELVAK----DDNLDSGNSNKDKSQQDKK 4831

Query: 645  LKRKQKALAEEA--SEEELPSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIEIE 702
             + K++A A++    E+++   +D  D Y   EV     N++ V   +    P++     
Sbjct: 4832 -EEKEEAEADDGGQGEDKINEQIDERD-YDENEVDPYHGNQEKVPEPEALDLPDD----- 4884

Query: 703  RQKAEMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARF 762
                   L +  ED++  +  +  +  E   L  K+K +    +     + E + N+++ 
Sbjct: 4885 -------LNLDSEDKNGGEDTDNEEGEEENPLEIKEKPEEAGHEAEERGETETDQNESQS 4937

Query: 763  QAMYTSHLFNLDPSDPNFKKTKAMEKILEEKARQRERKEQELTQAIKKKESEIEKE 818
                       D ++   +     +    + A+  E   +E  Q++++K+ E ++E
Sbjct: 4938 PQEPEEGPSEDDKAEGEEEMDTGADDQDGDAAQHPEEHSEEQQQSVEEKDKEADEE 4993



 Score = 33.5 bits (75), Expect = 0.86
 Identities = 74/406 (18%), Positives = 150/406 (36%), Gaps = 55/406 (13%)

Query: 54   DKRGRPISHSTTEDLKRFYDLSDSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEK 113
            +K   P +    +DL    +  +   +   E+ +  +  +IK+K  +   E + +   E 
Sbjct: 4871 EKVPEPEALDLPDDLNLDSEDKNGGEDTDNEEGEEENPLEIKEKPEEAGHEAEERGETET 4930

Query: 114  KKETKKANHKGSENKTDLDNSIGIKKMKTSCKFKI-DSNISPKKDSKEFTQKNKKEKKNI 172
             +   ++  +  E  ++ D + G ++M T    +  D+   P++ S+E  Q  +++ K  
Sbjct: 4931 DQNESQSPQEPEEGPSEDDKAEGEEEMDTGADDQDGDAAQHPEEHSEEQQQSVEEKDKEA 4990

Query: 173  VQHTTDS-------SLEEKQRTLDSGTSEIV-----KSPRIECSKTRREMQSVVQLI--- 217
             +   ++         +E++   DS T E V     +     C +T  E     Q +   
Sbjct: 4991 DEEGGENGPADQGFQPQEEEEREDSDTEEQVPEALERKEHASCGQTGVENMQNTQAMELA 5050

Query: 218  --MTRDSDGYENSTDGEMCDKDALEEDSESVSEIGSDEESENEITSVGRASG--DDDGSE 273
                    G E    G      A   +S  ++++ S + +     S  R  G  D++ S 
Sbjct: 5051 GAAPEKEQGKEEHGSGAADANQAEGHESNFIAQLASQKHTRKNTQSFKRKPGQADNERSM 5110

Query: 274  DDEEE---------DEDEEEDED---------EDSEDDDKSDSGPDLARGKGNIETSSED 315
             D  E         D D   ++          ED++  +    G D A      + +S++
Sbjct: 5111 GDHNERVHKRLRTVDTDSHAEQGPAQQPQAQVEDADAFEHIKQGSD-AYDAQTYDVASKE 5169

Query: 316  EDDTADLFPEESGFEHAWRELDKDAPRADEITRRLAVCNMDWDRLKAKDLLALFNSFKPK 375
            +  +A    ++SG +    E++      +E     A    D ++LK +++         K
Sbjct: 5170 QQQSA----KDSGKDQEEEEIEDTLMDTEEQEEFKAA---DVEQLKPEEI---------K 5213

Query: 376  GGVIFSVKIYPSEFGKERMKEEQVQGPVELLSIPEDAPEKDWTSRE 421
             G    +     E   + +K E+ Q P    +  E   EK   SRE
Sbjct: 5214 SGTTAPLGFDEMEVEIQTVKTEEDQDPRTDKAHKETENEKPERSRE 5259



 Score = 32.7 bits (73), Expect = 1.5
 Identities = 57/278 (20%), Positives = 110/278 (39%), Gaps = 41/278 (14%)

Query: 570  KSQKDDEEQIAKYRQLLQVIQEKEKKGKEN-DMEMEIKWVPG----------------LK 612
            +  KD  +QI    Q+    Q+ ++K KE+ D + +IK                    L+
Sbjct: 4684 EGMKDVSDQIGNEEQVEDTFQKGQEKDKEDPDSKSDIKGEDNAIEMSEDFDGKMHDGELE 4743

Query: 613  ESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASEEELPSDVDLNDPYF 672
            E  E+  K+  EG D L      L  ++  K  +R      EE  EEE  +  +   P  
Sbjct: 4744 EQEEDDEKSDSEGGD-LDKHMGDLNGEEADKLDERLWGDDDEEEDEEEEDNKTEETGPGM 4802

Query: 673  AEEVKQI---GINKKSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDEDSKKHFNYNKIV 729
             EE  ++     N  S  S KD +  +++ E E  +A         D+  +     N+ +
Sbjct: 4803 DEEDSELVAKDDNLDSGNSNKDKSQQDKKEEKEEAEA---------DDGGQGEDKINEQI 4853

Query: 730  EHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKAMEKI 789
            + ++  + +       +E + +   +++ D            NLD  D N  +    E+ 
Sbjct: 4854 DERDYDENEVDPYHGNQEKVPEPEALDLPDD----------LNLDSEDKNGGEDTDNEEG 4903

Query: 790  LEEKARQ-RERKEQELTQAIKKKESEIEKESQRKSIDP 826
             EE   + +E+ E+   +A ++ E+E ++   +   +P
Sbjct: 4904 EEENPLEIKEKPEEAGHEAEERGETETDQNESQSPQEP 4941


>gi|114155142 nuclear pore complex-associated protein TPR [Homo
            sapiens]
          Length = 2363

 Score = 62.4 bits (150), Expect = 2e-09
 Identities = 72/285 (25%), Positives = 122/285 (42%), Gaps = 23/285 (8%)

Query: 61   SHSTTEDLKRFYDLSDSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKA 120
            S    E +  F   S S  + S     ++SQ  I   + QT+     +   +   + + A
Sbjct: 1731 SEGPVEHVPVFGSTSGSVRSTSPNVQPSISQP-ILTVQQQTQATAFVQPTQQSHPQIEPA 1789

Query: 121  NHKGSENKTDLDNSIGIKKMKTSCKF-----KIDSNISPKKDSKEFTQKNKKEKKNIVQH 175
            N + S N  ++  S  +++  TS           S+  PK+  +E      +    +   
Sbjct: 1790 NQELSSNIVEVVQSSPVERPSTSTAVFGTVSATPSSSLPKRTREEEEDSTIEASDQVSDD 1849

Query: 176  TTDSSLEEKQRTLDS-GTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMC 234
            T +  L +K +++   GT E V +       T  E+++ V    ++DS G E  T G+  
Sbjct: 1850 TVEMPLPKKLKSVTPVGTEEEVMAEE----STDGEVETQVYNQDSQDSIG-EGVTQGDYT 1904

Query: 235  DKDALEEDSESVS-EIGSDEESENEITSV--GRASGDD-------DGSEDDEEED-EDEE 283
              +  EE S+S+  ++G  +  +   TS   G+  GDD       D  EDD+E D E E+
Sbjct: 1905 PMEDSEETSQSLQIDLGPLQSDQQTTTSSQDGQGKGDDVIVIDSDDEEEDDDENDGEHED 1964

Query: 284  EDEDEDSEDDDKSDSGPDLARGKGNIETSSEDEDDTADLFPEESG 328
             +EDE+ +DDD+ D+G        N  T S D +D  +    E G
Sbjct: 1965 YEEDEEDDDDDEDDTGMGDEGEDSNEGTGSADGNDGYEADDAEGG 2009



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 66/333 (19%), Positives = 149/333 (44%), Gaps = 51/333 (15%)

Query: 522 LNRKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKTKKSQKDDEEQIAK 581
           L++  K+    +   Q +L    + ++++E+E+       +E+ G+ +K  ++  + ++ 
Sbjct: 310 LHKLLKEAGEANKAIQDHLLEVEQSKDQMEKEM-------LEKIGRLEKELENANDLLSA 362

Query: 582 YRQLLQVIQEKEKKGKENDMEMEIKWV-PGLKESAEEMVKNKLEGKDKLTPWEQFLEKKK 640
            ++   ++ E+E            K V PG+K +  E+    +E +D+L      L +K 
Sbjct: 363 TKRKGAILSEEELAAMSPTAAAVAKIVKPGMKLT--ELYNAYVETQDQL------LLEKL 414

Query: 641 EKKRLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIE 700
           E KR+ +           +E+  +V+   P    + ++    +K+V S          ++
Sbjct: 415 ENKRINKYL---------DEIVKEVEAKAPILKRQREEYERAQKAVASLS--------VK 457

Query: 701 IERQKAEMALLMMDEDEDSKKHF-----NYNKIVEHQNLSKKKKKQLMKKKE-----LIE 750
           +E+   E+  L  D D+ +K+       N    ++ ++LS++ +  LM+ +E     +I 
Sbjct: 458 LEQAMKEIQRLQEDTDKANKQSSVLERDNRRMEIQVKDLSQQIRVLLMELEEARGNHVIR 517

Query: 751 DDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKARQRERKEQELTQAIKK 810
           D+   + + +    + + HL +    +   ++ + +   L E    RER+EQE T + K 
Sbjct: 518 DEEVSSADISSSSEVISQHLVSYRNIEELQQQNQRLLVALRELGETREREEQETTSS-KI 576

Query: 811 KESEIEKESQRKSIDPALSMLIKSIKTKTEQFQ 843
            E +++ ES       AL+ L +  K++  Q Q
Sbjct: 577 TELQLKLES-------ALTELEQLRKSRQHQMQ 602



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 45/215 (20%), Positives = 85/215 (39%), Gaps = 39/215 (18%)

Query: 168  EKKNIVQHTTDSSLE------EKQRTLDSGTSEIVKSPRIECSKTRREMQSVV------Q 215
            E++ + + +TD  +E      + Q ++  G ++   +P  +  +T + +Q  +      Q
Sbjct: 1868 EEEVMAEESTDGEVETQVYNQDSQDSIGEGVTQGDYTPMEDSEETSQSLQIDLGPLQSDQ 1927

Query: 216  LIMTRDSDGYENSTDGEMCDKDALEEDS-------ESVSEIGSDEESENEITSVG----- 263
               T   DG     D  + D D  EED        E   E   D++ + + T +G     
Sbjct: 1928 QTTTSSQDGQGKGDDVIVIDSDDEEEDDDENDGEHEDYEEDEEDDDDDEDDTGMGDEGED 1987

Query: 264  --RASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDSGPDLARGKGNIETSSEDEDDTAD 321
                +G  DG++  E +D +  +  D  +E ++       +  G+GN   +        +
Sbjct: 1988 SNEGTGSADGNDGYEADDAEGGDGTDPGTETEE------SMGGGEGNHRAADSQNSGEGN 2041

Query: 322  LFPEESGF-EHAWRE------LDKDAPRADEITRR 349
                ES F +   RE       ++ APRA +  RR
Sbjct: 2042 TGAAESSFSQEVSREQQPSSASERQAPRAPQSPRR 2076



 Score = 38.9 bits (89), Expect = 0.020
 Identities = 74/371 (19%), Positives = 153/371 (41%), Gaps = 43/371 (11%)

Query: 488  NLTAYKPKYFTSAAMGTSTVEITWDETDHER--ITMLNRKFKKEELLDMDFQAYLASSSE 545
            +L +   K  T     +   E+  D  +  R  IT L+ + +K        +  + + ++
Sbjct: 706  DLRSQNTKISTQLDFASKRYEMLQDNVEGYRREITSLHERNQKLTATTQKQEQIINTMTQ 765

Query: 546  DEEEIEEELQGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEMEI 605
            D     E+L   + V  E   K K+  K  E ++++ R+ L      E++G +N +   +
Sbjct: 766  DLRGANEKLAVAE-VRAENLKKEKEMLKLSEVRLSQQRESLLA----EQRG-QNLLLTNL 819

Query: 606  KWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASEEELPSDV 665
            + + G+ E +E   K +L          Q  + + E   LK+K +   E+        DV
Sbjct: 820  QTIQGILERSETETKQRLSS--------QIEKLEHEISHLKKKLENEVEQRHTLTRNLDV 871

Query: 666  DLNDPYFAEEVK-QIGINKKSV-KSAKD--GTSPEEEIEIERQKAEMALLMMDEDEDSKK 721
             L D     + +  + +N K + K+A+    T  +    +E Q A  +     + + S K
Sbjct: 872  QLLDTKRQLDTETNLHLNTKELLKNAQKEIATLKQHLSNMEVQVASQSSQRTGKGQPSNK 931

Query: 722  HFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNFK 781
              + + +V     ++++   L ++ +    + E      ++QAM TS        + +  
Sbjct: 932  E-DVDDLVSQLRQTEEQVNDLKERLKTSTSNVE------QYQAMVTS-------LEESLN 977

Query: 782  KTKAMEKILEEKARQRERKEQELTQAIKKKESEIEKESQR---------KSIDPALSMLI 832
            K K + + + +    R ++  E    ++KK  E+EKE Q          +S++  LS L 
Sbjct: 978  KEKQVTEEVRKNIEVRLKESAEFQTQLEKKLMEVEKEKQELQDDKRRAIESMEQQLSELK 1037

Query: 833  KSIKTKTEQFQ 843
            K++ +   + Q
Sbjct: 1038 KTLSSVQNEVQ 1048



 Score = 37.0 bits (84), Expect = 0.077
 Identities = 61/282 (21%), Positives = 117/282 (41%), Gaps = 46/282 (16%)

Query: 576  EEQIAKYRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQF 635
            +EQ++K   + Q ++E  +K +   +E +  W     E  E M+K+++    K     + 
Sbjct: 1100 KEQVSKMASVRQHLEETTQKAESQLLECKASW-----EERERMLKDEVS---KCVCRCED 1151

Query: 636  LEKKKE---KKRLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGINKKSVKSAKDG 692
            LEK+      +  K   K +A      + P +V L++   ++E  QI    + ++  K+ 
Sbjct: 1152 LEKQNRLLHDQIEKLSDKVVASVKEGVQGPLNVSLSEEGKSQE--QILEILRFIRREKEI 1209

Query: 693  TSPEEEI-EIE----RQKAEMALLMMDEDEDS------KKHFNYNKIVEHQNLSKKKK-- 739
                 E+ ++E    RQ+ E+    + E +DS      K       + +H+ L KK +  
Sbjct: 1210 AETRFEVAQVESLRYRQRVELLERELQELQDSLNAEREKVQVTAKTMAQHEELMKKTETM 1269

Query: 740  -------KQLMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKAM----EK 788
                   K L ++KE +E D +      R   +    +  L  ++    +   M    +K
Sbjct: 1270 NVVMETNKMLREEKERLEQDLQQMQAKVRKLEL---DILPLQEANAELSEKSGMLQAEKK 1326

Query: 789  ILEEKARQRERKEQELTQAIKKKESE------IEKESQRKSI 824
            +LEE  ++ + + Q L    K  ++E       EKE   K I
Sbjct: 1327 LLEEDVKRWKARNQHLVSQQKDPDTEEYRKLLSEKEVHTKRI 1368


>gi|115529449 upstream binding transcription factor, RNA polymerase
           I isoform b [Homo sapiens]
          Length = 727

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 77/331 (23%), Positives = 128/331 (38%), Gaps = 44/331 (13%)

Query: 21  RFWEMPEKDRKVKIDKRFRAMFHDKKFKLNYAVDKRGR-PISHSTTEDLKRFYDLSDSDS 79
           R W    + +K K   R  A+    + K     ++RG+ P S    E++ +   + D  +
Sbjct: 406 RMWNDLSEKKKAKYKAREAALKAQSERKPGGEREERGKLPESPKRAEEIWQQSVIGDYLA 465

Query: 80  NLSGEDSKALSQKKI-------KKKKTQTKKEIDSKNLVEKK-----------KETKKAN 121
               +  KAL   ++       K+K    KK  + +   E++             +KK  
Sbjct: 466 RFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAAEDQKRYERELSEMRAPPAATNSSKKMK 525

Query: 122 HKGSENKTDLDNSIGIKKMKTSCKFKIDSNISPKKDS--------KEFTQKNKKEKKNIV 173
            +G   K  ++   G +K         + N  P K+         +  +Q  K+  K + 
Sbjct: 526 FQGEPKKPPMN---GYQKFSQELLSNGELNHLPLKERMVEIGSRWQRISQSQKEHYKKLA 582

Query: 174 QHTTDSSLEEKQRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEM 233
                   EE+Q+         VKS   +     +E  S  +  MT+       S+   +
Sbjct: 583 --------EEQQKQYKVHLDLWVKSLSPQDRAAYKEYISNKRKSMTKLRGPNPKSSRTTL 634

Query: 234 CDKDALEEDSESVSEIGSDEESENEITSVGRASGD----DDGSEDDEEEDEDEEEDEDED 289
             K   EED E   E   DE+ E E    G +S D     + S +DE ED DE E++DED
Sbjct: 635 QSKSESEEDDEE-DEDDEDEDEEEEDDENGDSSEDGGDSSESSSEDESEDGDENEEDDED 693

Query: 290 SEDDDKSDSGPD-LARGKGNIETSSEDEDDT 319
            +DD+  D   D  + G  +  +SS D  D+
Sbjct: 694 EDDDEDDDEDEDNESEGSSSSSSSSGDSSDS 724


>gi|115529451 upstream binding transcription factor, RNA polymerase
           I isoform b [Homo sapiens]
          Length = 727

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 77/331 (23%), Positives = 128/331 (38%), Gaps = 44/331 (13%)

Query: 21  RFWEMPEKDRKVKIDKRFRAMFHDKKFKLNYAVDKRGR-PISHSTTEDLKRFYDLSDSDS 79
           R W    + +K K   R  A+    + K     ++RG+ P S    E++ +   + D  +
Sbjct: 406 RMWNDLSEKKKAKYKAREAALKAQSERKPGGEREERGKLPESPKRAEEIWQQSVIGDYLA 465

Query: 80  NLSGEDSKALSQKKI-------KKKKTQTKKEIDSKNLVEKK-----------KETKKAN 121
               +  KAL   ++       K+K    KK  + +   E++             +KK  
Sbjct: 466 RFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAAEDQKRYERELSEMRAPPAATNSSKKMK 525

Query: 122 HKGSENKTDLDNSIGIKKMKTSCKFKIDSNISPKKDS--------KEFTQKNKKEKKNIV 173
            +G   K  ++   G +K         + N  P K+         +  +Q  K+  K + 
Sbjct: 526 FQGEPKKPPMN---GYQKFSQELLSNGELNHLPLKERMVEIGSRWQRISQSQKEHYKKLA 582

Query: 174 QHTTDSSLEEKQRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEM 233
                   EE+Q+         VKS   +     +E  S  +  MT+       S+   +
Sbjct: 583 --------EEQQKQYKVHLDLWVKSLSPQDRAAYKEYISNKRKSMTKLRGPNPKSSRTTL 634

Query: 234 CDKDALEEDSESVSEIGSDEESENEITSVGRASGD----DDGSEDDEEEDEDEEEDEDED 289
             K   EED E   E   DE+ E E    G +S D     + S +DE ED DE E++DED
Sbjct: 635 QSKSESEEDDEE-DEDDEDEDEEEEDDENGDSSEDGGDSSESSSEDESEDGDENEEDDED 693

Query: 290 SEDDDKSDSGPD-LARGKGNIETSSEDEDDT 319
            +DD+  D   D  + G  +  +SS D  D+
Sbjct: 694 EDDDEDDDEDEDNESEGSSSSSSSSGDSSDS 724


>gi|7657671 upstream binding transcription factor, RNA polymerase I
           isoform a [Homo sapiens]
          Length = 764

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 77/331 (23%), Positives = 128/331 (38%), Gaps = 44/331 (13%)

Query: 21  RFWEMPEKDRKVKIDKRFRAMFHDKKFKLNYAVDKRGR-PISHSTTEDLKRFYDLSDSDS 79
           R W    + +K K   R  A+    + K     ++RG+ P S    E++ +   + D  +
Sbjct: 443 RMWNDLSEKKKAKYKAREAALKAQSERKPGGEREERGKLPESPKRAEEIWQQSVIGDYLA 502

Query: 80  NLSGEDSKALSQKKI-------KKKKTQTKKEIDSKNLVEKK-----------KETKKAN 121
               +  KAL   ++       K+K    KK  + +   E++             +KK  
Sbjct: 503 RFKNDRVKALKAMEMTWNNMEKKEKLMWIKKAAEDQKRYERELSEMRAPPAATNSSKKMK 562

Query: 122 HKGSENKTDLDNSIGIKKMKTSCKFKIDSNISPKKDS--------KEFTQKNKKEKKNIV 173
            +G   K  ++   G +K         + N  P K+         +  +Q  K+  K + 
Sbjct: 563 FQGEPKKPPMN---GYQKFSQELLSNGELNHLPLKERMVEIGSRWQRISQSQKEHYKKLA 619

Query: 174 QHTTDSSLEEKQRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEM 233
                   EE+Q+         VKS   +     +E  S  +  MT+       S+   +
Sbjct: 620 --------EEQQKQYKVHLDLWVKSLSPQDRAAYKEYISNKRKSMTKLRGPNPKSSRTTL 671

Query: 234 CDKDALEEDSESVSEIGSDEESENEITSVGRASGD----DDGSEDDEEEDEDEEEDEDED 289
             K   EED E   E   DE+ E E    G +S D     + S +DE ED DE E++DED
Sbjct: 672 QSKSESEEDDEE-DEDDEDEDEEEEDDENGDSSEDGGDSSESSSEDESEDGDENEEDDED 730

Query: 290 SEDDDKSDSGPD-LARGKGNIETSSEDEDDT 319
            +DD+  D   D  + G  +  +SS D  D+
Sbjct: 731 EDDDEDDDEDEDNESEGSSSSSSSSGDSSDS 761


>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
            sapiens]
          Length = 1972

 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 166/875 (18%), Positives = 348/875 (39%), Gaps = 144/875 (16%)

Query: 74   LSDSDSNLSGEDSKALSQKKIKKK--------KTQTKKEIDSKNLVEKKKETKKANHKG- 124
            +SD  +NL+ E+ KA +  K+K K        + + KKE  S+  +EK K   + +    
Sbjct: 1008 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067

Query: 125  SENKTDLDNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSSLEEK 184
             E   DL   I   KM+ + K + +   +  +   E  QKN   KK       +  + + 
Sbjct: 1068 HEQIADLQAQIAELKMQLA-KKEEELQAALARLDDEIAQKNNALKK---IRELEGHISDL 1123

Query: 185  QRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKDALEEDSE 244
            Q  LDS      ++ R +  K +R++   ++ + T   D           D  A +++  
Sbjct: 1124 QEDLDS-----ERAARNKAEKQKRDLGEELEALKTELED---------TLDSTATQQELR 1169

Query: 245  SVSEIGSDEESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDSGPDLAR 304
            +        + E E+T + +A  ++  S     E + +E  +      ++ ++      R
Sbjct: 1170 A--------KREQEVTVLKKALDEETRS----HEAQVQEMRQKHAQAVEELTEQLEQFKR 1217

Query: 305  GKGNIETSSED-EDDTADLFPEESGFEHAWRELDKDAPRADEITRRLAVCNMDWDRLKAK 363
             K N++ + +  E + ADL  E      A +E++    + +   + L     D +R +A+
Sbjct: 1218 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277

Query: 364  ---DLLALFNSFKPKGGVIFSVKIYPSEFGKE-RMKEEQVQGPVELL------------- 406
                +  L N  +   G++   +    +  K+      Q+Q   ELL             
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337

Query: 407  --------SIPEDAPEKDWTSREKLRDY----------QFKRLKYYYAVVDCDSPETASK 448
                    +  +D  +++  +++ L  +            K+L+ + + V+    E   +
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA-LEEGKKR 1396

Query: 449  IYEDCDGL--EFESSCSFID--------LRFIPDDITFD-DEPKDVASEVNLTAYKPKYF 497
              ++ + L  ++E   +  D        L+   DD+  D D  + + S  NL   + K+ 
Sbjct: 1397 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS--NLEKKQRKFD 1454

Query: 498  TSAAMGTSTVEITWDETDHERITMLNRKFKKEELLDMDFQAYLASSSEDEEEIE------ 551
               A   +      DE D         + +++E   +     L  + E +EE+E      
Sbjct: 1455 QLLAEEKNISSKYADERDR-----AEAEAREKETKALSLARALEEALEAKEELERTNKML 1509

Query: 552  ----EEL---QGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEME 604
                E+L   + D G NV E    +KS++  E Q+ + +  L+ ++++ +  ++  + +E
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHE---LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566

Query: 605  IKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASE------ 658
            +       +   ++     + ++K    ++ L + + +   +RKQ+ALA  A +      
Sbjct: 1567 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1626

Query: 659  EELPSDVDLNDPYFAEEVKQIGINKKSVK----SAKDGTSPEEEI-------EIERQKAE 707
            ++L    D       E +KQ+   +  +K      +D  +  +EI       E + +  E
Sbjct: 1627 KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1686

Query: 708  MALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQAMYT 767
              L+ + ED  + +       +E + L+++    L  +  L ++   +    A+ +    
Sbjct: 1687 ADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1746

Query: 768  SHLFNLDP-SDPNFKKTKAMEKILEEKARQR-------------ERKEQELTQAIKKKES 813
                N++  SD   K T+  E++  E A +R             ER+ +EL   + + E 
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1806

Query: 814  EIEKESQRKSIDPALSMLIKSIKTKTEQFQARKKQ 848
             +  +S+ KS   AL   I  ++ + EQ +AR+KQ
Sbjct: 1807 AV--KSKFKSTIAALEAKIAQLEEQVEQ-EAREKQ 1838



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 169/869 (19%), Positives = 335/869 (38%), Gaps = 146/869 (16%)

Query: 68   LKRFYDLSDSDSNLSGE-DSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANHKGSE 126
            LK+  +L    S+L  + DS+  ++ K +K+K    +E+++  L  + ++T  +     E
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA--LKTELEDTLDSTATQQE 1167

Query: 127  NKTDLDNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTD-----SSL 181
             +   +  + + K     K   +   S +   +E  QK+ +  + + +         ++L
Sbjct: 1168 LRAKREQEVTVLK-----KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL 1222

Query: 182  EEKQRTLDSGTSEIVKSPRI------ECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCD 235
            ++ ++TL+   +++    R+      E    ++++++ VQ + ++ SDG       E+ D
Sbjct: 1223 DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG--ERARAELND 1280

Query: 236  K-DALEEDSESVSEIGSDEESE-----NEITSVGRASGDDDGSEDDEEEDE--------- 280
            K   L+ + ESV+ + ++ E +      ++ S+     D      +E   +         
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340

Query: 281  -DEEEDEDEDSEDDDK-----------------SDSGPDLARGKGNIETSSED----EDD 318
             +EE +  +D  D++                  SDS   L      +E   E     + +
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400

Query: 319  TADLFPEESGFEHAWRELDKDAPR---------ADEITRRLAVCNMDWDRLKAKDLLALF 369
              +L  +      A+ +L+K   R          D   +R  V N++  + K   LLA  
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1460

Query: 370  NSFKPKGGVIFSVKIYPSEFGKERMKEEQVQGPVELLSIPEDAPEKDWTSREKLRDYQFK 429
             +   K         Y  E  ++R + E  +   + LS+   A E+   ++E+L     K
Sbjct: 1461 KNISSK---------YADE--RDRAEAEAREKETKALSLAR-ALEEALEAKEELERTN-K 1507

Query: 430  RLKYYYAVVDCDSPETASKIYE---DCDGLEFESSCSFIDLRFIPDDITFDDEPKDVASE 486
             LK     +     +    ++E       LE +       L  + D++   ++ K +  E
Sbjct: 1508 MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK-LRLE 1566

Query: 487  VNLTAYKPKYFTSAAMGTSTVEITWDETDHERITMLNRKFKK--EELLDMDFQAYLASSS 544
            VN+ A K ++               DE + E+   L R+  +   EL D   Q  LA+++
Sbjct: 1567 VNMQALKGQFERDLQAR--------DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1618

Query: 545  EDEEE---IEEELQGDDGVNVEEDG---------KTKKSQKDDEEQIAKYRQLLQVIQEK 592
            + + E    + ELQ D  +   E+          + K  Q++ E+  A   ++    +E 
Sbjct: 1619 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1678

Query: 593  EKKGK--ENDM----------EMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKK 640
            EKK K  E D+          E   K     KE   E + + L G++ L       EK++
Sbjct: 1679 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD-----EKRR 1733

Query: 641  EKKRLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIE 700
             + R+ + ++ L EE    E  SD        AE++      ++S     +    +    
Sbjct: 1734 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ---- 1789

Query: 701  IERQKAEMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVN-D 759
            +ERQ  E+                 +K+ E +   K K K  +   E      E  V  +
Sbjct: 1790 LERQNKELR----------------SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833

Query: 760  ARFQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKARQRERKEQELTQAIKKKESEIEKES 819
            AR +   T  L   D            E+ + E+ +++  K     + +K++  E E+ES
Sbjct: 1834 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1893

Query: 820  QRKSIDPALSMLIKSIKTKTEQFQARKKQ 848
            QR  I+     L + +   TE  +A  ++
Sbjct: 1894 QR--INANRRKLQRELDEATESNEAMGRE 1920



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 74/371 (19%), Positives = 149/371 (40%), Gaps = 64/371 (17%)

Query: 513  ETDHERIT----MLNRKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKT 568
            E  H ++T    +L  + + E  L  + +      +  ++E+EE L   +    EE+ + 
Sbjct: 879  EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG 938

Query: 569  KKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKLEGKDK 628
            ++ Q + ++   +   L + ++E+E   ++  +E         K +AE  +K KLE    
Sbjct: 939  QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE---------KVTAEAKIK-KLE---- 984

Query: 629  LTPWEQFLEKKKEKKRLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGINKKSVKS 688
                ++ L    +  +L +++K L E  S        DL      EE K   + K  +K+
Sbjct: 985  ----DEILVMDDQNNKLSKERKLLEERIS--------DLTTNLAEEEEKAKNLTK--LKN 1030

Query: 689  AKDGTSPEEEIEIER-QKAEMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKE 747
              +    E E+ +++ +K+   L  +    +      + +I + Q    + K QL KK+E
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1090

Query: 748  -------LIEDDFEVNVNDARFQAMYTSHLFNL--DPSDPNFKKTKA------------- 785
                    ++D+     N  +       H+ +L  D       + KA             
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150

Query: 786  ----MEKILEEKARQRE---RKEQELTQAIKKKESEIEKESQRKSIDPALSMLIKSIKTK 838
                +E  L+  A Q+E   ++EQE+T  + KK  + E  S    +        ++++  
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVT--VLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1208

Query: 839  TEQFQARKKQK 849
            TEQ +  K+ K
Sbjct: 1209 TEQLEQFKRAK 1219


>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
            sapiens]
          Length = 1979

 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 166/875 (18%), Positives = 348/875 (39%), Gaps = 144/875 (16%)

Query: 74   LSDSDSNLSGEDSKALSQKKIKKK--------KTQTKKEIDSKNLVEKKKETKKANHKG- 124
            +SD  +NL+ E+ KA +  K+K K        + + KKE  S+  +EK K   + +    
Sbjct: 1015 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074

Query: 125  SENKTDLDNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSSLEEK 184
             E   DL   I   KM+ + K + +   +  +   E  QKN   KK       +  + + 
Sbjct: 1075 HEQIADLQAQIAELKMQLA-KKEEELQAALARLDDEIAQKNNALKK---IRELEGHISDL 1130

Query: 185  QRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKDALEEDSE 244
            Q  LDS      ++ R +  K +R++   ++ + T   D           D  A +++  
Sbjct: 1131 QEDLDS-----ERAARNKAEKQKRDLGEELEALKTELED---------TLDSTATQQELR 1176

Query: 245  SVSEIGSDEESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDSGPDLAR 304
            +        + E E+T + +A  ++  S     E + +E  +      ++ ++      R
Sbjct: 1177 A--------KREQEVTVLKKALDEETRS----HEAQVQEMRQKHAQAVEELTEQLEQFKR 1224

Query: 305  GKGNIETSSED-EDDTADLFPEESGFEHAWRELDKDAPRADEITRRLAVCNMDWDRLKAK 363
             K N++ + +  E + ADL  E      A +E++    + +   + L     D +R +A+
Sbjct: 1225 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284

Query: 364  ---DLLALFNSFKPKGGVIFSVKIYPSEFGKE-RMKEEQVQGPVELL------------- 406
                +  L N  +   G++   +    +  K+      Q+Q   ELL             
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344

Query: 407  --------SIPEDAPEKDWTSREKLRDY----------QFKRLKYYYAVVDCDSPETASK 448
                    +  +D  +++  +++ L  +            K+L+ + + V+    E   +
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA-LEEGKKR 1403

Query: 449  IYEDCDGL--EFESSCSFID--------LRFIPDDITFD-DEPKDVASEVNLTAYKPKYF 497
              ++ + L  ++E   +  D        L+   DD+  D D  + + S  NL   + K+ 
Sbjct: 1404 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS--NLEKKQRKFD 1461

Query: 498  TSAAMGTSTVEITWDETDHERITMLNRKFKKEELLDMDFQAYLASSSEDEEEIE------ 551
               A   +      DE D         + +++E   +     L  + E +EE+E      
Sbjct: 1462 QLLAEEKNISSKYADERDR-----AEAEAREKETKALSLARALEEALEAKEELERTNKML 1516

Query: 552  ----EEL---QGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEME 604
                E+L   + D G NV E    +KS++  E Q+ + +  L+ ++++ +  ++  + +E
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHE---LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573

Query: 605  IKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASE------ 658
            +       +   ++     + ++K    ++ L + + +   +RKQ+ALA  A +      
Sbjct: 1574 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1633

Query: 659  EELPSDVDLNDPYFAEEVKQIGINKKSVK----SAKDGTSPEEEI-------EIERQKAE 707
            ++L    D       E +KQ+   +  +K      +D  +  +EI       E + +  E
Sbjct: 1634 KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1693

Query: 708  MALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQAMYT 767
              L+ + ED  + +       +E + L+++    L  +  L ++   +    A+ +    
Sbjct: 1694 ADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1753

Query: 768  SHLFNLDP-SDPNFKKTKAMEKILEEKARQR-------------ERKEQELTQAIKKKES 813
                N++  SD   K T+  E++  E A +R             ER+ +EL   + + E 
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1813

Query: 814  EIEKESQRKSIDPALSMLIKSIKTKTEQFQARKKQ 848
             +  +S+ KS   AL   I  ++ + EQ +AR+KQ
Sbjct: 1814 AV--KSKFKSTIAALEAKIAQLEEQVEQ-EAREKQ 1845



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 169/869 (19%), Positives = 335/869 (38%), Gaps = 146/869 (16%)

Query: 68   LKRFYDLSDSDSNLSGE-DSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANHKGSE 126
            LK+  +L    S+L  + DS+  ++ K +K+K    +E+++  L  + ++T  +     E
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA--LKTELEDTLDSTATQQE 1174

Query: 127  NKTDLDNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTD-----SSL 181
             +   +  + + K     K   +   S +   +E  QK+ +  + + +         ++L
Sbjct: 1175 LRAKREQEVTVLK-----KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL 1229

Query: 182  EEKQRTLDSGTSEIVKSPRI------ECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCD 235
            ++ ++TL+   +++    R+      E    ++++++ VQ + ++ SDG       E+ D
Sbjct: 1230 DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG--ERARAELND 1287

Query: 236  K-DALEEDSESVSEIGSDEESE-----NEITSVGRASGDDDGSEDDEEEDE--------- 280
            K   L+ + ESV+ + ++ E +      ++ S+     D      +E   +         
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347

Query: 281  -DEEEDEDEDSEDDDK-----------------SDSGPDLARGKGNIETSSED----EDD 318
             +EE +  +D  D++                  SDS   L      +E   E     + +
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407

Query: 319  TADLFPEESGFEHAWRELDKDAPR---------ADEITRRLAVCNMDWDRLKAKDLLALF 369
              +L  +      A+ +L+K   R          D   +R  V N++  + K   LLA  
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1467

Query: 370  NSFKPKGGVIFSVKIYPSEFGKERMKEEQVQGPVELLSIPEDAPEKDWTSREKLRDYQFK 429
             +   K         Y  E  ++R + E  +   + LS+   A E+   ++E+L     K
Sbjct: 1468 KNISSK---------YADE--RDRAEAEAREKETKALSLAR-ALEEALEAKEELERTN-K 1514

Query: 430  RLKYYYAVVDCDSPETASKIYE---DCDGLEFESSCSFIDLRFIPDDITFDDEPKDVASE 486
             LK     +     +    ++E       LE +       L  + D++   ++ K +  E
Sbjct: 1515 MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK-LRLE 1573

Query: 487  VNLTAYKPKYFTSAAMGTSTVEITWDETDHERITMLNRKFKK--EELLDMDFQAYLASSS 544
            VN+ A K ++               DE + E+   L R+  +   EL D   Q  LA+++
Sbjct: 1574 VNMQALKGQFERDLQAR--------DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1625

Query: 545  EDEEE---IEEELQGDDGVNVEEDG---------KTKKSQKDDEEQIAKYRQLLQVIQEK 592
            + + E    + ELQ D  +   E+          + K  Q++ E+  A   ++    +E 
Sbjct: 1626 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1685

Query: 593  EKKGK--ENDM----------EMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKK 640
            EKK K  E D+          E   K     KE   E + + L G++ L       EK++
Sbjct: 1686 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD-----EKRR 1740

Query: 641  EKKRLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIE 700
             + R+ + ++ L EE    E  SD        AE++      ++S     +    +    
Sbjct: 1741 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ---- 1796

Query: 701  IERQKAEMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVN-D 759
            +ERQ  E+                 +K+ E +   K K K  +   E      E  V  +
Sbjct: 1797 LERQNKELR----------------SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840

Query: 760  ARFQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKARQRERKEQELTQAIKKKESEIEKES 819
            AR +   T  L   D            E+ + E+ +++  K     + +K++  E E+ES
Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1900

Query: 820  QRKSIDPALSMLIKSIKTKTEQFQARKKQ 848
            QR  I+     L + +   TE  +A  ++
Sbjct: 1901 QR--INANRRKLQRELDEATESNEAMGRE 1927



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 74/371 (19%), Positives = 149/371 (40%), Gaps = 64/371 (17%)

Query: 513  ETDHERIT----MLNRKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKT 568
            E  H ++T    +L  + + E  L  + +      +  ++E+EE L   +    EE+ + 
Sbjct: 886  EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG 945

Query: 569  KKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKLEGKDK 628
            ++ Q + ++   +   L + ++E+E   ++  +E         K +AE  +K KLE    
Sbjct: 946  QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE---------KVTAEAKIK-KLE---- 991

Query: 629  LTPWEQFLEKKKEKKRLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGINKKSVKS 688
                ++ L    +  +L +++K L E  S        DL      EE K   + K  +K+
Sbjct: 992  ----DEILVMDDQNNKLSKERKLLEERIS--------DLTTNLAEEEEKAKNLTK--LKN 1037

Query: 689  AKDGTSPEEEIEIER-QKAEMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKE 747
              +    E E+ +++ +K+   L  +    +      + +I + Q    + K QL KK+E
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1097

Query: 748  -------LIEDDFEVNVNDARFQAMYTSHLFNL--DPSDPNFKKTKA------------- 785
                    ++D+     N  +       H+ +L  D       + KA             
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157

Query: 786  ----MEKILEEKARQRE---RKEQELTQAIKKKESEIEKESQRKSIDPALSMLIKSIKTK 838
                +E  L+  A Q+E   ++EQE+T  + KK  + E  S    +        ++++  
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVT--VLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1215

Query: 839  TEQFQARKKQK 849
            TEQ +  K+ K
Sbjct: 1216 TEQLEQFKRAK 1226


>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
            sapiens]
          Length = 1945

 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 166/875 (18%), Positives = 348/875 (39%), Gaps = 144/875 (16%)

Query: 74   LSDSDSNLSGEDSKALSQKKIKKK--------KTQTKKEIDSKNLVEKKKETKKANHKG- 124
            +SD  +NL+ E+ KA +  K+K K        + + KKE  S+  +EK K   + +    
Sbjct: 1015 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1074

Query: 125  SENKTDLDNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSSLEEK 184
             E   DL   I   KM+ + K + +   +  +   E  QKN   KK       +  + + 
Sbjct: 1075 HEQIADLQAQIAELKMQLA-KKEEELQAALARLDDEIAQKNNALKK---IRELEGHISDL 1130

Query: 185  QRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKDALEEDSE 244
            Q  LDS      ++ R +  K +R++   ++ + T   D           D  A +++  
Sbjct: 1131 QEDLDS-----ERAARNKAEKQKRDLGEELEALKTELED---------TLDSTATQQELR 1176

Query: 245  SVSEIGSDEESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDSGPDLAR 304
            +        + E E+T + +A  ++  S     E + +E  +      ++ ++      R
Sbjct: 1177 A--------KREQEVTVLKKALDEETRS----HEAQVQEMRQKHAQAVEELTEQLEQFKR 1224

Query: 305  GKGNIETSSED-EDDTADLFPEESGFEHAWRELDKDAPRADEITRRLAVCNMDWDRLKAK 363
             K N++ + +  E + ADL  E      A +E++    + +   + L     D +R +A+
Sbjct: 1225 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1284

Query: 364  ---DLLALFNSFKPKGGVIFSVKIYPSEFGKE-RMKEEQVQGPVELL------------- 406
                +  L N  +   G++   +    +  K+      Q+Q   ELL             
Sbjct: 1285 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1344

Query: 407  --------SIPEDAPEKDWTSREKLRDY----------QFKRLKYYYAVVDCDSPETASK 448
                    +  +D  +++  +++ L  +            K+L+ + + V+    E   +
Sbjct: 1345 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA-LEEGKKR 1403

Query: 449  IYEDCDGL--EFESSCSFID--------LRFIPDDITFD-DEPKDVASEVNLTAYKPKYF 497
              ++ + L  ++E   +  D        L+   DD+  D D  + + S  NL   + K+ 
Sbjct: 1404 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS--NLEKKQRKFD 1461

Query: 498  TSAAMGTSTVEITWDETDHERITMLNRKFKKEELLDMDFQAYLASSSEDEEEIE------ 551
               A   +      DE D         + +++E   +     L  + E +EE+E      
Sbjct: 1462 QLLAEEKNISSKYADERDR-----AEAEAREKETKALSLARALEEALEAKEELERTNKML 1516

Query: 552  ----EEL---QGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEME 604
                E+L   + D G NV E    +KS++  E Q+ + +  L+ ++++ +  ++  + +E
Sbjct: 1517 KAEMEDLVSSKDDVGKNVHE---LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1573

Query: 605  IKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASE------ 658
            +       +   ++     + ++K    ++ L + + +   +RKQ+ALA  A +      
Sbjct: 1574 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1633

Query: 659  EELPSDVDLNDPYFAEEVKQIGINKKSVK----SAKDGTSPEEEI-------EIERQKAE 707
            ++L    D       E +KQ+   +  +K      +D  +  +EI       E + +  E
Sbjct: 1634 KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1693

Query: 708  MALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQAMYT 767
              L+ + ED  + +       +E + L+++    L  +  L ++   +    A+ +    
Sbjct: 1694 ADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1753

Query: 768  SHLFNLDP-SDPNFKKTKAMEKILEEKARQR-------------ERKEQELTQAIKKKES 813
                N++  SD   K T+  E++  E A +R             ER+ +EL   + + E 
Sbjct: 1754 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1813

Query: 814  EIEKESQRKSIDPALSMLIKSIKTKTEQFQARKKQ 848
             +  +S+ KS   AL   I  ++ + EQ +AR+KQ
Sbjct: 1814 AV--KSKFKSTIAALEAKIAQLEEQVEQ-EAREKQ 1845



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 169/869 (19%), Positives = 335/869 (38%), Gaps = 146/869 (16%)

Query: 68   LKRFYDLSDSDSNLSGE-DSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANHKGSE 126
            LK+  +L    S+L  + DS+  ++ K +K+K    +E+++  L  + ++T  +     E
Sbjct: 1117 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA--LKTELEDTLDSTATQQE 1174

Query: 127  NKTDLDNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTD-----SSL 181
             +   +  + + K     K   +   S +   +E  QK+ +  + + +         ++L
Sbjct: 1175 LRAKREQEVTVLK-----KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL 1229

Query: 182  EEKQRTLDSGTSEIVKSPRI------ECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCD 235
            ++ ++TL+   +++    R+      E    ++++++ VQ + ++ SDG       E+ D
Sbjct: 1230 DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG--ERARAELND 1287

Query: 236  K-DALEEDSESVSEIGSDEESE-----NEITSVGRASGDDDGSEDDEEEDE--------- 280
            K   L+ + ESV+ + ++ E +      ++ S+     D      +E   +         
Sbjct: 1288 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1347

Query: 281  -DEEEDEDEDSEDDDK-----------------SDSGPDLARGKGNIETSSED----EDD 318
             +EE +  +D  D++                  SDS   L      +E   E     + +
Sbjct: 1348 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1407

Query: 319  TADLFPEESGFEHAWRELDKDAPR---------ADEITRRLAVCNMDWDRLKAKDLLALF 369
              +L  +      A+ +L+K   R          D   +R  V N++  + K   LLA  
Sbjct: 1408 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1467

Query: 370  NSFKPKGGVIFSVKIYPSEFGKERMKEEQVQGPVELLSIPEDAPEKDWTSREKLRDYQFK 429
             +   K         Y  E  ++R + E  +   + LS+   A E+   ++E+L     K
Sbjct: 1468 KNISSK---------YADE--RDRAEAEAREKETKALSLAR-ALEEALEAKEELERTN-K 1514

Query: 430  RLKYYYAVVDCDSPETASKIYE---DCDGLEFESSCSFIDLRFIPDDITFDDEPKDVASE 486
             LK     +     +    ++E       LE +       L  + D++   ++ K +  E
Sbjct: 1515 MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK-LRLE 1573

Query: 487  VNLTAYKPKYFTSAAMGTSTVEITWDETDHERITMLNRKFKK--EELLDMDFQAYLASSS 544
            VN+ A K ++               DE + E+   L R+  +   EL D   Q  LA+++
Sbjct: 1574 VNMQALKGQFERDLQAR--------DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1625

Query: 545  EDEEE---IEEELQGDDGVNVEEDG---------KTKKSQKDDEEQIAKYRQLLQVIQEK 592
            + + E    + ELQ D  +   E+          + K  Q++ E+  A   ++    +E 
Sbjct: 1626 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1685

Query: 593  EKKGK--ENDM----------EMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKK 640
            EKK K  E D+          E   K     KE   E + + L G++ L       EK++
Sbjct: 1686 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD-----EKRR 1740

Query: 641  EKKRLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIE 700
             + R+ + ++ L EE    E  SD        AE++      ++S     +    +    
Sbjct: 1741 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ---- 1796

Query: 701  IERQKAEMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVN-D 759
            +ERQ  E+                 +K+ E +   K K K  +   E      E  V  +
Sbjct: 1797 LERQNKELR----------------SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1840

Query: 760  ARFQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKARQRERKEQELTQAIKKKESEIEKES 819
            AR +   T  L   D            E+ + E+ +++  K     + +K++  E E+ES
Sbjct: 1841 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1900

Query: 820  QRKSIDPALSMLIKSIKTKTEQFQARKKQ 848
            QR  I+     L + +   TE  +A  ++
Sbjct: 1901 QR--INANRRKLQRELDEATESNEAMGRE 1927



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 74/371 (19%), Positives = 149/371 (40%), Gaps = 64/371 (17%)

Query: 513  ETDHERIT----MLNRKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKT 568
            E  H ++T    +L  + + E  L  + +      +  ++E+EE L   +    EE+ + 
Sbjct: 886  EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG 945

Query: 569  KKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKLEGKDK 628
            ++ Q + ++   +   L + ++E+E   ++  +E         K +AE  +K KLE    
Sbjct: 946  QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE---------KVTAEAKIK-KLE---- 991

Query: 629  LTPWEQFLEKKKEKKRLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGINKKSVKS 688
                ++ L    +  +L +++K L E  S        DL      EE K   + K  +K+
Sbjct: 992  ----DEILVMDDQNNKLSKERKLLEERIS--------DLTTNLAEEEEKAKNLTK--LKN 1037

Query: 689  AKDGTSPEEEIEIER-QKAEMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKE 747
              +    E E+ +++ +K+   L  +    +      + +I + Q    + K QL KK+E
Sbjct: 1038 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1097

Query: 748  -------LIEDDFEVNVNDARFQAMYTSHLFNL--DPSDPNFKKTKA------------- 785
                    ++D+     N  +       H+ +L  D       + KA             
Sbjct: 1098 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1157

Query: 786  ----MEKILEEKARQRE---RKEQELTQAIKKKESEIEKESQRKSIDPALSMLIKSIKTK 838
                +E  L+  A Q+E   ++EQE+T  + KK  + E  S    +        ++++  
Sbjct: 1158 LKTELEDTLDSTATQQELRAKREQEVT--VLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1215

Query: 839  TEQFQARKKQK 849
            TEQ +  K+ K
Sbjct: 1216 TEQLEQFKRAK 1226


>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
            sapiens]
          Length = 1938

 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 166/875 (18%), Positives = 348/875 (39%), Gaps = 144/875 (16%)

Query: 74   LSDSDSNLSGEDSKALSQKKIKKK--------KTQTKKEIDSKNLVEKKKETKKANHKG- 124
            +SD  +NL+ E+ KA +  K+K K        + + KKE  S+  +EK K   + +    
Sbjct: 1008 ISDLTTNLAEEEEKAKNLTKLKNKHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDF 1067

Query: 125  SENKTDLDNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSSLEEK 184
             E   DL   I   KM+ + K + +   +  +   E  QKN   KK       +  + + 
Sbjct: 1068 HEQIADLQAQIAELKMQLA-KKEEELQAALARLDDEIAQKNNALKK---IRELEGHISDL 1123

Query: 185  QRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKDALEEDSE 244
            Q  LDS      ++ R +  K +R++   ++ + T   D           D  A +++  
Sbjct: 1124 QEDLDS-----ERAARNKAEKQKRDLGEELEALKTELED---------TLDSTATQQELR 1169

Query: 245  SVSEIGSDEESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDSGPDLAR 304
            +        + E E+T + +A  ++  S     E + +E  +      ++ ++      R
Sbjct: 1170 A--------KREQEVTVLKKALDEETRS----HEAQVQEMRQKHAQAVEELTEQLEQFKR 1217

Query: 305  GKGNIETSSED-EDDTADLFPEESGFEHAWRELDKDAPRADEITRRLAVCNMDWDRLKAK 363
             K N++ + +  E + ADL  E      A +E++    + +   + L     D +R +A+
Sbjct: 1218 AKANLDKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDGERARAE 1277

Query: 364  ---DLLALFNSFKPKGGVIFSVKIYPSEFGKE-RMKEEQVQGPVELL------------- 406
                +  L N  +   G++   +    +  K+      Q+Q   ELL             
Sbjct: 1278 LNDKVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTK 1337

Query: 407  --------SIPEDAPEKDWTSREKLRDY----------QFKRLKYYYAVVDCDSPETASK 448
                    +  +D  +++  +++ L  +            K+L+ + + V+    E   +
Sbjct: 1338 LRQLEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEA-LEEGKKR 1396

Query: 449  IYEDCDGL--EFESSCSFID--------LRFIPDDITFD-DEPKDVASEVNLTAYKPKYF 497
              ++ + L  ++E   +  D        L+   DD+  D D  + + S  NL   + K+ 
Sbjct: 1397 FQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVS--NLEKKQRKFD 1454

Query: 498  TSAAMGTSTVEITWDETDHERITMLNRKFKKEELLDMDFQAYLASSSEDEEEIE------ 551
               A   +      DE D         + +++E   +     L  + E +EE+E      
Sbjct: 1455 QLLAEEKNISSKYADERDR-----AEAEAREKETKALSLARALEEALEAKEELERTNKML 1509

Query: 552  ----EEL---QGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEME 604
                E+L   + D G NV E    +KS++  E Q+ + +  L+ ++++ +  ++  + +E
Sbjct: 1510 KAEMEDLVSSKDDVGKNVHE---LEKSKRALETQMEEMKTQLEELEDELQATEDAKLRLE 1566

Query: 605  IKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASE------ 658
            +       +   ++     + ++K    ++ L + + +   +RKQ+ALA  A +      
Sbjct: 1567 VNMQALKGQFERDLQARDEQNEEKRRQLQRQLHEYETELEDERKQRALAAAAKKKLEGDL 1626

Query: 659  EELPSDVDLNDPYFAEEVKQIGINKKSVK----SAKDGTSPEEEI-------EIERQKAE 707
            ++L    D       E +KQ+   +  +K      +D  +  +EI       E + +  E
Sbjct: 1627 KDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKENEKKAKSLE 1686

Query: 708  MALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQAMYT 767
              L+ + ED  + +       +E + L+++    L  +  L ++   +    A+ +    
Sbjct: 1687 ADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQDEKRRLEARIAQLEEELE 1746

Query: 768  SHLFNLDP-SDPNFKKTKAMEKILEEKARQR-------------ERKEQELTQAIKKKES 813
                N++  SD   K T+  E++  E A +R             ER+ +EL   + + E 
Sbjct: 1747 EEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQLERQNKELRSKLHEMEG 1806

Query: 814  EIEKESQRKSIDPALSMLIKSIKTKTEQFQARKKQ 848
             +  +S+ KS   AL   I  ++ + EQ +AR+KQ
Sbjct: 1807 AV--KSKFKSTIAALEAKIAQLEEQVEQ-EAREKQ 1838



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 169/869 (19%), Positives = 335/869 (38%), Gaps = 146/869 (16%)

Query: 68   LKRFYDLSDSDSNLSGE-DSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANHKGSE 126
            LK+  +L    S+L  + DS+  ++ K +K+K    +E+++  L  + ++T  +     E
Sbjct: 1110 LKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA--LKTELEDTLDSTATQQE 1167

Query: 127  NKTDLDNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTD-----SSL 181
             +   +  + + K     K   +   S +   +E  QK+ +  + + +         ++L
Sbjct: 1168 LRAKREQEVTVLK-----KALDEETRSHEAQVQEMRQKHAQAVEELTEQLEQFKRAKANL 1222

Query: 182  EEKQRTLDSGTSEIVKSPRI------ECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCD 235
            ++ ++TL+   +++    R+      E    ++++++ VQ + ++ SDG       E+ D
Sbjct: 1223 DKNKQTLEKENADLAGELRVLGQAKQEVEHKKKKLEAQVQELQSKCSDG--ERARAELND 1280

Query: 236  K-DALEEDSESVSEIGSDEESE-----NEITSVGRASGDDDGSEDDEEEDE--------- 280
            K   L+ + ESV+ + ++ E +      ++ S+     D      +E   +         
Sbjct: 1281 KVHKLQNEVESVTGMLNEAEGKAIKLAKDVASLSSQLQDTQELLQEETRQKLNVSTKLRQ 1340

Query: 281  -DEEEDEDEDSEDDDK-----------------SDSGPDLARGKGNIETSSED----EDD 318
             +EE +  +D  D++                  SDS   L      +E   E     + +
Sbjct: 1341 LEEERNSLQDQLDEEMEAKQNLERHISTLNIQLSDSKKKLQDFASTVEALEEGKKRFQKE 1400

Query: 319  TADLFPEESGFEHAWRELDKDAPR---------ADEITRRLAVCNMDWDRLKAKDLLALF 369
              +L  +      A+ +L+K   R          D   +R  V N++  + K   LLA  
Sbjct: 1401 IENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDNQRQLVSNLEKKQRKFDQLLAEE 1460

Query: 370  NSFKPKGGVIFSVKIYPSEFGKERMKEEQVQGPVELLSIPEDAPEKDWTSREKLRDYQFK 429
             +   K         Y  E  ++R + E  +   + LS+   A E+   ++E+L     K
Sbjct: 1461 KNISSK---------YADE--RDRAEAEAREKETKALSLAR-ALEEALEAKEELERTN-K 1507

Query: 430  RLKYYYAVVDCDSPETASKIYE---DCDGLEFESSCSFIDLRFIPDDITFDDEPKDVASE 486
             LK     +     +    ++E       LE +       L  + D++   ++ K +  E
Sbjct: 1508 MLKAEMEDLVSSKDDVGKNVHELEKSKRALETQMEEMKTQLEELEDELQATEDAK-LRLE 1566

Query: 487  VNLTAYKPKYFTSAAMGTSTVEITWDETDHERITMLNRKFKK--EELLDMDFQAYLASSS 544
            VN+ A K ++               DE + E+   L R+  +   EL D   Q  LA+++
Sbjct: 1567 VNMQALKGQFERDLQAR--------DEQNEEKRRQLQRQLHEYETELEDERKQRALAAAA 1618

Query: 545  EDEEE---IEEELQGDDGVNVEEDG---------KTKKSQKDDEEQIAKYRQLLQVIQEK 592
            + + E    + ELQ D  +   E+          + K  Q++ E+  A   ++    +E 
Sbjct: 1619 KKKLEGDLKDLELQADSAIKGREEAIKQLRKLQAQMKDFQRELEDARASRDEIFATAKEN 1678

Query: 593  EKKGK--ENDM----------EMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKK 640
            EKK K  E D+          E   K     KE   E + + L G++ L       EK++
Sbjct: 1679 EKKAKSLEADLMQLQEDLAAAERARKQADLEKEELAEELASSLSGRNALQD-----EKRR 1733

Query: 641  EKKRLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIE 700
             + R+ + ++ L EE    E  SD        AE++      ++S     +    +    
Sbjct: 1734 LEARIAQLEEELEEEQGNMEAMSDRVRKATQQAEQLSNELATERSTAQKNESARQQ---- 1789

Query: 701  IERQKAEMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVN-D 759
            +ERQ  E+                 +K+ E +   K K K  +   E      E  V  +
Sbjct: 1790 LERQNKELR----------------SKLHEMEGAVKSKFKSTIAALEAKIAQLEEQVEQE 1833

Query: 760  ARFQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKARQRERKEQELTQAIKKKESEIEKES 819
            AR +   T  L   D            E+ + E+ +++  K     + +K++  E E+ES
Sbjct: 1834 AREKQAATKSLKQKDKKLKEILLQVEDERKMAEQYKEQAEKGNARVKQLKRQLEEAEEES 1893

Query: 820  QRKSIDPALSMLIKSIKTKTEQFQARKKQ 848
            QR  I+     L + +   TE  +A  ++
Sbjct: 1894 QR--INANRRKLQRELDEATESNEAMGRE 1920



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 74/371 (19%), Positives = 149/371 (40%), Gaps = 64/371 (17%)

Query: 513  ETDHERIT----MLNRKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKT 568
            E  H ++T    +L  + + E  L  + +      +  ++E+EE L   +    EE+ + 
Sbjct: 879  EQKHSQLTEEKNLLQEQLQAETELYAEAEEMRVRLAAKKQELEEILHEMEARLEEEEDRG 938

Query: 569  KKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKLEGKDK 628
            ++ Q + ++   +   L + ++E+E   ++  +E         K +AE  +K KLE    
Sbjct: 939  QQLQAERKKMAQQMLDLEEQLEEEEAARQKLQLE---------KVTAEAKIK-KLE---- 984

Query: 629  LTPWEQFLEKKKEKKRLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGINKKSVKS 688
                ++ L    +  +L +++K L E  S        DL      EE K   + K  +K+
Sbjct: 985  ----DEILVMDDQNNKLSKERKLLEERIS--------DLTTNLAEEEEKAKNLTK--LKN 1030

Query: 689  AKDGTSPEEEIEIER-QKAEMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKE 747
              +    E E+ +++ +K+   L  +    +      + +I + Q    + K QL KK+E
Sbjct: 1031 KHESMISELEVRLKKEEKSRQELEKLKRKLEGDASDFHEQIADLQAQIAELKMQLAKKEE 1090

Query: 748  -------LIEDDFEVNVNDARFQAMYTSHLFNL--DPSDPNFKKTKA------------- 785
                    ++D+     N  +       H+ +L  D       + KA             
Sbjct: 1091 ELQAALARLDDEIAQKNNALKKIRELEGHISDLQEDLDSERAARNKAEKQKRDLGEELEA 1150

Query: 786  ----MEKILEEKARQRE---RKEQELTQAIKKKESEIEKESQRKSIDPALSMLIKSIKTK 838
                +E  L+  A Q+E   ++EQE+T  + KK  + E  S    +        ++++  
Sbjct: 1151 LKTELEDTLDSTATQQELRAKREQEVT--VLKKALDEETRSHEAQVQEMRQKHAQAVEEL 1208

Query: 839  TEQFQARKKQK 849
            TEQ +  K+ K
Sbjct: 1209 TEQLEQFKRAK 1219


>gi|20336205 transcriptional regulator ATRX isoform 2 [Homo sapiens]
          Length = 2454

 Score = 60.1 bits (144), Expect = 9e-09
 Identities = 161/845 (19%), Positives = 313/845 (37%), Gaps = 125/845 (14%)

Query: 69   KRFYDLSDSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANHKGSENK 128
            KR    S S S+   +  K+     I KKK QT+ E  + +  E +KE K  +  G+   
Sbjct: 740  KRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDS-ELEKEIKSMSKIGAART 798

Query: 129  T--------DLDNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKN-------IV 173
            T        D D+S   K  K     +   N+   ++      + K+E++        + 
Sbjct: 799  TKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVD 858

Query: 174  QHTTDSSLEE---KQRTLDSGTSEIVKSPRIECSKTRREMQSVVQL----------IMTR 220
            + TT   L +   K++   + T  + K    E S T  E++ V +              +
Sbjct: 859  KDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKK 918

Query: 221  DSDGYENSTDG--EMCDKDALEEDSESVSEIGSDEESENE------ITSVGRASGDDDGS 272
              DG  +  +   +    D   ED +  S+ G++E+ +        I    +     DG+
Sbjct: 919  VQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGT 978

Query: 273  EDDEEEDE--------------------DEEEDEDEDSEDDDKSDSGPDLARGKGNIETS 312
            E   E +E                      ++  D+ S+  D+     + + GKG+   S
Sbjct: 979  EKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDS 1038

Query: 313  SEDEDDTADLFPEESGF-----EHAWRELDKDAPRADEITRRLAVCNMDWDRLKAKDLLA 367
            SED+      +  E        + + +  D  +   ++ + +   CN    RLK  +L  
Sbjct: 1039 SEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRE 1098

Query: 368  LFNSFKPKGGVIFSVKIYPSEFGKERMKEEQVQGPVELLSIPEDAPEKDWTSREKLRDYQ 427
              N                     +R  +E   G     S   DA E    +++K +   
Sbjct: 1099 RRN------------------LSSKRNTKEIQSG-----SSSSDAEESSEDNKKKKQRTS 1135

Query: 428  FKRLKYYYAVVDCDSPETASKIYEDCDGLEFESSCSFIDLRFIPDDITFDDEPKDVASEV 487
             K+          +S  T++K  +        S     D   I +  + + + K V   +
Sbjct: 1136 SKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENL 1195

Query: 488  NLTAYKPKYFTSAAMGTS-TVEITWDETDHERITMLNRKFKKEELLDMDFQAYLASSSED 546
             L+++     +S     S +V +T D+ D +       +  K+ LL+ + +A L SS ED
Sbjct: 1196 VLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDP--ENRIAKKMLLE-EIKANL-SSDED 1251

Query: 547  EEEIEEELQGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEMEIK 606
                +E  +G      +  GK  +    DEE              K +   E+D + E  
Sbjct: 1252 GSSDDEPEEGK-----KRTGKQNEENPGDEEA-------------KNQVNSESDSDSEES 1293

Query: 607  WVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASEEELPSDVD 666
              P  +     ++++KL   D  +  E+  + K+ K+   R ++ ++ E SE     D D
Sbjct: 1294 KKPRYRH---RLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSE-----DSD 1345

Query: 667  LNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDEDSKKHFNYN 726
              +   +EEV +    ++    +      EE     +QK +   + + ED  S+   N  
Sbjct: 1346 FQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSE 1405

Query: 727  KIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKAM 786
            +        +++K++  +++E  E++ E   +D++        +  +   D    +T+  
Sbjct: 1406 E-------EEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDK--LRTETQ 1456

Query: 787  EKILEEKARQRERKEQELTQAIKKKESEIEKESQRKSIDPALSMLIKSIKTKTEQFQARK 846
              + EE+ R++   E+E  +   ++  EIE  S  K       +L +  +TK    Q  +
Sbjct: 1457 NALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETKEPLVQVHR 1516

Query: 847  KQKVK 851
               +K
Sbjct: 1517 NMVIK 1521



 Score = 30.8 bits (68), Expect = 5.6
 Identities = 57/241 (23%), Positives = 96/241 (39%), Gaps = 43/241 (17%)

Query: 60  ISHSTTEDLKRFYDLSDSDSNLSGEDSKALSQ--KKIKKKKTQTKKEIDSK----NLVEK 113
           ++ S  + LK+  D S+  S       KA       IKK     +++++S+    + V K
Sbjct: 328 MNSSYVKFLKQATDNSEISSATKLRQLKAFKSVLADIKKAHLALEEDLNSEFRAMDAVNK 387

Query: 114 KKETKKANHKGSENKTDLDNSIGIKKMKTSCKFKIDSNISPKKD-SKEFTQKNKKEKKNI 172
           +K TK+  HK  + K +       +K +  C  +       KKD SK   + ++K+  + 
Sbjct: 388 EKNTKE--HKVIDAKFETK----ARKGEKPCALE-------KKDISKSEAKLSRKQVDS- 433

Query: 173 VQHTTDSSLEEKQRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGE 232
            +H   +   E+QRT  S   E  KS R                   ++   YE +   E
Sbjct: 434 -EHMHQNVPTEEQRTNKSTGGEHKKSDR-------------------KEEPQYEPANTSE 473

Query: 233 MCDKDALEEDSESVSEIGSDEESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSED 292
             D D +   S    +I  + E+  E+ S     G  DGS   E+E E      +  S+D
Sbjct: 474 DLDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQG--DGSSGTEQEVESSSVKLNISSKD 531

Query: 293 D 293
           +
Sbjct: 532 N 532



 Score = 30.0 bits (66), Expect = 9.5
 Identities = 56/294 (19%), Positives = 119/294 (40%), Gaps = 48/294 (16%)

Query: 564 EDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKL 623
           +  +T     D +E +A  +++ ++          N++    K +  LK  A +  K K 
Sbjct: 682 KQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKR 741

Query: 624 EGKDKLTPWE-----------QFLEKKKEK-------------KRLKRKQKALAEEASEE 659
           + K   +  +             + KKK +             K +K   K  A   +++
Sbjct: 742 KRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKK 801

Query: 660 ELPSDVDLNDPYFAEEVKQIGINK--KSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDE 717
            +P+  D +     +  K+   N+  K++K++++G+S + E + ER+    A   +D+D 
Sbjct: 802 RIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKD- 860

Query: 718 DSKKHFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSD 777
                     I+E        + +L KK++       V+    + Q+  +  +  +  + 
Sbjct: 861 --------TTIME-------LRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETK 905

Query: 778 PNFK--KTKAMEKI---LEEKARQRERKEQ-ELTQAIKKKESEIEKESQRKSID 825
              K  KTK  +K+   L + A +  +K+Q + T    KK+S+   E ++K  D
Sbjct: 906 EKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSD 959


>gi|20336209 transcriptional regulator ATRX isoform 1 [Homo sapiens]
          Length = 2492

 Score = 60.1 bits (144), Expect = 9e-09
 Identities = 161/845 (19%), Positives = 313/845 (37%), Gaps = 125/845 (14%)

Query: 69   KRFYDLSDSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANHKGSENK 128
            KR    S S S+   +  K+     I KKK QT+ E  + +  E +KE K  +  G+   
Sbjct: 778  KRKRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDS-ELEKEIKSMSKIGAART 836

Query: 129  T--------DLDNSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKN-------IV 173
            T        D D+S   K  K     +   N+   ++      + K+E++        + 
Sbjct: 837  TKKRIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVD 896

Query: 174  QHTTDSSLEE---KQRTLDSGTSEIVKSPRIECSKTRREMQSVVQL----------IMTR 220
            + TT   L +   K++   + T  + K    E S T  E++ V +              +
Sbjct: 897  KDTTIMELRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETKEKSKHLKTKTCKK 956

Query: 221  DSDGYENSTDG--EMCDKDALEEDSESVSEIGSDEESENE------ITSVGRASGDDDGS 272
              DG  +  +   +    D   ED +  S+ G++E+ +        I    +     DG+
Sbjct: 957  VQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSDFKKKVIKMEQQYESSSDGT 1016

Query: 273  EDDEEEDE--------------------DEEEDEDEDSEDDDKSDSGPDLARGKGNIETS 312
            E   E +E                      ++  D+ S+  D+     + + GKG+   S
Sbjct: 1017 EKLPEREEICHFPKGIKQIKNGTTDGEKKSKKIRDKTSKKKDELSDYAEKSTGKGDSCDS 1076

Query: 313  SEDEDDTADLFPEESGF-----EHAWRELDKDAPRADEITRRLAVCNMDWDRLKAKDLLA 367
            SED+      +  E        + + +  D  +   ++ + +   CN    RLK  +L  
Sbjct: 1077 SEDKKSKNGAYGREKKRCKLLGKSSRKRQDCSSSDTEKYSMKEDGCNSSDKRLKRIELRE 1136

Query: 368  LFNSFKPKGGVIFSVKIYPSEFGKERMKEEQVQGPVELLSIPEDAPEKDWTSREKLRDYQ 427
              N                     +R  +E   G     S   DA E    +++K +   
Sbjct: 1137 RRN------------------LSSKRNTKEIQSG-----SSSSDAEESSEDNKKKKQRTS 1173

Query: 428  FKRLKYYYAVVDCDSPETASKIYEDCDGLEFESSCSFIDLRFIPDDITFDDEPKDVASEV 487
             K+          +S  T++K  +        S     D   I +  + + + K V   +
Sbjct: 1174 SKKKAVIVKEKKRNSLRTSTKRKQADITSSSSSDIEDDDQNSIGEGSSDEQKIKPVTENL 1233

Query: 488  NLTAYKPKYFTSAAMGTS-TVEITWDETDHERITMLNRKFKKEELLDMDFQAYLASSSED 546
             L+++     +S     S +V +T D+ D +       +  K+ LL+ + +A L SS ED
Sbjct: 1234 VLSSHTGFCQSSGDEALSKSVPVTVDDDDDDNDP--ENRIAKKMLLE-EIKANL-SSDED 1289

Query: 547  EEEIEEELQGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEMEIK 606
                +E  +G      +  GK  +    DEE              K +   E+D + E  
Sbjct: 1290 GSSDDEPEEGK-----KRTGKQNEENPGDEEA-------------KNQVNSESDSDSEES 1331

Query: 607  WVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASEEELPSDVD 666
              P  +     ++++KL   D  +  E+  + K+ K+   R ++ ++ E SE     D D
Sbjct: 1332 KKPRYRH---RLLRHKLTVSDGESGEEKKTKPKEHKEVKGRNRRKVSSEDSE-----DSD 1383

Query: 667  LNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDEDSKKHFNYN 726
              +   +EEV +    ++    +      EE     +QK +   + + ED  S+   N  
Sbjct: 1384 FQESGVSEEVSESEDEQRPRTRSAKKAELEENQRSYKQKKKRRRIKVQEDSSSENKSNSE 1443

Query: 727  KIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKAM 786
            +        +++K++  +++E  E++ E   +D++        +  +   D    +T+  
Sbjct: 1444 E-------EEEEKEEEEEEEEEEEEEEEDENDDSKSPGKGRKKIRKILKDDK--LRTETQ 1494

Query: 787  EKILEEKARQRERKEQELTQAIKKKESEIEKESQRKSIDPALSMLIKSIKTKTEQFQARK 846
              + EE+ R++   E+E  +   ++  EIE  S  K       +L +  +TK    Q  +
Sbjct: 1495 NALKEEEERRKRIAEREREREKLREVIEIEDASPTKCPITTKLVLDEDEETKEPLVQVHR 1554

Query: 847  KQKVK 851
               +K
Sbjct: 1555 NMVIK 1559



 Score = 30.8 bits (68), Expect = 5.6
 Identities = 57/241 (23%), Positives = 96/241 (39%), Gaps = 43/241 (17%)

Query: 60  ISHSTTEDLKRFYDLSDSDSNLSGEDSKALSQ--KKIKKKKTQTKKEIDSK----NLVEK 113
           ++ S  + LK+  D S+  S       KA       IKK     +++++S+    + V K
Sbjct: 366 MNSSYVKFLKQATDNSEISSATKLRQLKAFKSVLADIKKAHLALEEDLNSEFRAMDAVNK 425

Query: 114 KKETKKANHKGSENKTDLDNSIGIKKMKTSCKFKIDSNISPKKD-SKEFTQKNKKEKKNI 172
           +K TK+  HK  + K +       +K +  C  +       KKD SK   + ++K+  + 
Sbjct: 426 EKNTKE--HKVIDAKFETK----ARKGEKPCALE-------KKDISKSEAKLSRKQVDS- 471

Query: 173 VQHTTDSSLEEKQRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGE 232
            +H   +   E+QRT  S   E  KS R                   ++   YE +   E
Sbjct: 472 -EHMHQNVPTEEQRTNKSTGGEHKKSDR-------------------KEEPQYEPANTSE 511

Query: 233 MCDKDALEEDSESVSEIGSDEESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSED 292
             D D +   S    +I  + E+  E+ S     G  DGS   E+E E      +  S+D
Sbjct: 512 DLDMDIVSVPSSVPEDIFENLETAMEVQSSVDHQG--DGSSGTEQEVESSSVKLNISSKD 569

Query: 293 D 293
           +
Sbjct: 570 N 570



 Score = 30.4 bits (67), Expect = 7.3
 Identities = 29/131 (22%), Positives = 57/131 (43%), Gaps = 21/131 (16%)

Query: 209 EMQSVVQLIMTRDSDGYENSTDGEMCDKDALEEDSESVSEIGSD----EESENEITSVGR 264
           ++ ++VQ +    +   E S +     + A+ ++++ +S  GS+    E S+ E TS   
Sbjct: 10  KLNTLVQKLHDFLAHSSEESEETSSPPRLAMNQNTDKISGSGSNSDMMENSKEEGTSSSE 69

Query: 265 ASGDDDGSE--------------DDEEEDEDEEEDEDEDSEDDDKSDSGPDLARGKGNIE 310
            S     S               DDE+  +DE  +ED  +E+ +   +   L +G   ++
Sbjct: 70  KSKSSGSSRSKRKPSIVTKYVESDDEKPLDDETVNEDASNENSENDITMQSLPKGTVIVQ 129

Query: 311 TS---SEDEDD 318
                +ED+DD
Sbjct: 130 PEPVLNEDKDD 140



 Score = 30.0 bits (66), Expect = 9.5
 Identities = 56/294 (19%), Positives = 119/294 (40%), Gaps = 48/294 (16%)

Query: 564 EDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKL 623
           +  +T     D +E +A  +++ ++          N++    K +  LK  A +  K K 
Sbjct: 720 KQSETVDQNSDSDEMLAILKEVSRMSHSSSSDTDINEIHTNHKTLYDLKTQAGKDDKGKR 779

Query: 624 EGKDKLTPWE-----------QFLEKKKEK-------------KRLKRKQKALAEEASEE 659
           + K   +  +             + KKK +             K +K   K  A   +++
Sbjct: 780 KRKSSTSGSDFDTKKGKSAKSSIISKKKRQTQSESSNYDSELEKEIKSMSKIGAARTTKK 839

Query: 660 ELPSDVDLNDPYFAEEVKQIGINK--KSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDE 717
            +P+  D +     +  K+   N+  K++K++++G+S + E + ER+    A   +D+D 
Sbjct: 840 RIPNTKDFDSSEDEKHSKKGMDNQGHKNLKTSQEGSSDDAERKQERETFSSAEGTVDKD- 898

Query: 718 DSKKHFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSD 777
                     I+E        + +L KK++       V+    + Q+  +  +  +  + 
Sbjct: 899 --------TTIME-------LRDRLPKKQQASASTDGVDKLSGKEQSFTSLEVRKVAETK 943

Query: 778 PNFK--KTKAMEKI---LEEKARQRERKEQ-ELTQAIKKKESEIEKESQRKSID 825
              K  KTK  +K+   L + A +  +K+Q + T    KK+S+   E ++K  D
Sbjct: 944 EKSKHLKTKTCKKVQDGLSDIAEKFLKKDQSDETSEDDKKQSKKGTEEKKKPSD 997


>gi|71061468 centromere protein E [Homo sapiens]
          Length = 2701

 Score = 60.1 bits (144), Expect = 9e-09
 Identities = 104/503 (20%), Positives = 214/503 (42%), Gaps = 57/503 (11%)

Query: 391  KERMKE-----EQVQGPVELLSIPEDAPEKDWTSREKLRDYQFKRLKYYYAVVD------ 439
            KE+MKE     +Q++  ++L     +A +K     EK     F  +    +++D      
Sbjct: 652  KEKMKELATTYKQMENDIQLYQSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKD 711

Query: 440  -----------CDSPETASKIYEDCDGLEFESSCSFIDLRFIPDDIT-FDDEPKDVASEV 487
                        D  +  +K  E+ + L  E      +L+ +P ++     E +D + E+
Sbjct: 712  LLCNLELEGKITDLQKELNKEVEENEALR-EEVILLSELKSLPSEVERLRKEIQDKSEEL 770

Query: 488  NL-TAYKPKYFTSAAMGTSTVEITWDETDHERITMLNRKFKKEELLDMDFQAYLASSSED 546
            ++ T+ K K F+      S V+   +E    +  +   +   +   D +FQ +     + 
Sbjct: 771  HIITSEKDKLFSEVVHKESRVQGLLEEIGKTKDDLATTQSNYKST-DQEFQNFKTLHMDF 829

Query: 547  EEEIEEELQGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKE-----NDM 601
            E++ +  L+ ++ +N E    +K++QK D    A   +L    QE ++K +E     N+M
Sbjct: 830  EQKYKMVLEENERMNQEIVNLSKEAQKFDSSLGALKTELSYKTQELQEKTREVQERLNEM 889

Query: 602  EMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKK----EKKRLKRKQKALAEEAS 657
            E   + +     + + + + K    +KL   +Q LE+ K    EK  LK+ Q++L  +  
Sbjct: 890  EQLKEQLENRDSTLQTVEREKTLITEKL---QQTLEEVKTLTQEKDDLKQLQESL--QIE 944

Query: 658  EEELPSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDE 717
             ++L SD+        +  +Q+   + +++S K        ++ +  +     L M+E+ 
Sbjct: 945  RDQLKSDIHDTVNMNIDTQEQL---RNALESLKQHQETINTLKSKISEEVSRNLHMEENT 1001

Query: 718  DSKKHFNYNKIV---EHQNLSKKKKKQL---MKKKELIEDD---FEVNVNDARFQAMYTS 768
               K     K+V   + Q+L  K  + L   +K  E+IE     F +       Q M  S
Sbjct: 1002 GETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLES 1061

Query: 769  HLFNLDPSDPNFKKTKAMEKILEEKAR---QRERKEQELTQAIKKKESEIEKESQRKSID 825
             +   +    + K+   M    +E+ R      +K+QE+    ++K   I+KE +     
Sbjct: 1062 VIAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEI--VAQEKNHAIKKEGELSRTC 1119

Query: 826  PALSMLIKSIKTKTEQFQARKKQ 848
              L+ + + +K K++Q Q +++Q
Sbjct: 1120 DRLAEVEEKLKEKSQQLQEKQQQ 1142



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 144/828 (17%), Positives = 316/828 (38%), Gaps = 96/828 (11%)

Query: 85   DSKALSQKKIKKKKTQTK-KEIDSKNLVEKKKETKKANHKGSENKTDLDNS-IGIKKMKT 142
            D  A  ++K+K+K  Q + K+    N+ E+  E +K  ++    K +L N  + ++ M+T
Sbjct: 1120 DRLAEVEEKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMET 1179

Query: 143  SCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQ--HTTDSSLEEKQRTLDSG---TSEIVK 197
              + ++   ++   +  +   K +K  K + +   T    L    R +++    T E +K
Sbjct: 1180 E-RLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELK 1238

Query: 198  SPRIECSK--------TRREMQSVVQLIMTRDSDGYENSTDGEMCDKDALEEDSESVSEI 249
               I   +         R   +   Q+I T+D +        E+      +E   +V E+
Sbjct: 1239 IAHIHLKEHQETIDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQELLPNVKEV 1298

Query: 250  GSDEESENEITSVGRASGDDDGSEDDEEEDEDEEEDED-EDSEDDDKSDSGPDLARGKGN 308
               +E+ NE+  +   S   D +     E E    +E  ++S+++ KS     L + + N
Sbjct: 1299 SETQETMNELELLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKS-----LTKERDN 1353

Query: 309  IETSSEDEDDTADLFPEESGFEHAWRELDKDAPRADEITRRLAVCNMDWDRLKAKDLLAL 368
            ++T  E  +   D        EH    L K      +  + L +   D +  K   +++ 
Sbjct: 1354 LKTIKEALEVKHDQLK-----EHIRETLAKIQESQSKQEQSLNMKEKDNETTK---IVSE 1405

Query: 369  FNSFKPKGGVIFSVKIYPSEFGKERMKEEQVQGPV-----ELLSIPEDAPEKDWTSREKL 423
               FKPK   +  ++I      K   +       V     +L  + E    +    +E +
Sbjct: 1406 MEQFKPKDSALLRIEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENI 1465

Query: 424  RDYQFKRL--KYYYAVVDC---DSPETASKIYEDCDGLEFESSCSFIDLRFIPDDI---- 474
            ++   K L  +    V  C   +  ET +++  +    E E S     L  I D +    
Sbjct: 1466 KEIVAKHLETEEELKVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKI 1525

Query: 475  --TFDDEPKDVASEVNLTAYKPKYFTSAAMGTSTVEITWDETDHERITMLNRKFKKEELL 532
               ++ E +    +++    K              +      + + + + NR  + +E +
Sbjct: 1526 QEIYEKEEQFNIKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEI 1585

Query: 533  DMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLLQVIQ-- 590
             +     +    E+ + ++E LQ +     E   +     K+ +E+  ++ ++  V +  
Sbjct: 1586 QI-----MIKEKEEMKRVQEALQIERDQLKENTKEIVAKMKESQEKEYQFLKMTAVNETQ 1640

Query: 591  -------------EKEKKGKENDMEMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLE 637
                         E +K   EN     I+    L E+ EEM ++  + +D L   E+ L+
Sbjct: 1641 EKMCEIEHLKEQFETQKLNLENIETENIRLTQILHENLEEM-RSVTKERDDLRSVEETLK 1699

Query: 638  KKKEKKRLKRKQKALAEEASEEEL----------PSDVDLNDPYFAEEVKQIGINKKSVK 687
             ++++ +   ++    +   +EEL             +D      +E+  +I   +K ++
Sbjct: 1700 VERDQLKENLRETITRDLEKQEELKIVHMHLKEHQETIDKLRGIVSEKTNEISNMQKDLE 1759

Query: 688  SAKDGTSPEE-EIEIERQKAEMALLMMDE---------DEDSKKHFNYNKIVEHQNLSKK 737
             + D    ++ +I+ E + A M L    E          E + K  N  K +E+ N   +
Sbjct: 1760 HSNDALKAQDLKIQEELRIAHMHLKEQQETIDKLRGIVSEKTDKLSNMQKDLENSNAKLQ 1819

Query: 738  KKKQLMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKARQR 797
            +K Q +K  E      + +VN+ + +      L          K+ K     L +   + 
Sbjct: 1820 EKIQELKANEHQLITLKKDVNETQKKVSEMEQL---------KKQIKDQSLTLSKLEIEN 1870

Query: 798  ERKEQELTQAIKKKESEIEKESQRKSIDPALSMLIKSIKTKTEQFQAR 845
                Q+L + +++ +S +++    + ++  L +    +K   ++ +AR
Sbjct: 1871 LNLAQKLHENLEEMKSVMKERDNLRRVEETLKLERDQLKESLQETKAR 1918



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 77/377 (20%), Positives = 156/377 (41%), Gaps = 57/377 (15%)

Query: 515  DHERITMLNRKFKKEELLDMDFQAYLASSSEDEEEIEEELQG--DDGVNVEEDGKTKKSQ 572
            + E + +L  + KK+       Q  +A       + E EL    D    VEE  K K  Q
Sbjct: 1083 NQEELRLLGDELKKQ-------QEIVAQEKNHAIKKEGELSRTCDRLAEVEEKLKEKSQQ 1135

Query: 573  KDDEEQIAKYRQLLQVIQE-KEKKGKENDMEMEIKWVPGLKESAEEMVKNKLEGKDKLTP 631
              +++Q     QLL V +E  E + K N++E     +   + + E M   +LE   KL  
Sbjct: 1136 LQEKQQ-----QLLNVQEEMSEMQKKINEIENLKNELKNKELTLEHMETERLELAQKLNE 1190

Query: 632  -WEQFLEKKKEKKRLKRKQKALAEE------------ASEEELPSDVDLNDPYFAEEVKQ 678
             +E+     KE+K LK  QK+   E            A+  +   ++ +   +  E  + 
Sbjct: 1191 NYEEVKSITKERKVLKELQKSFETERDHLRGYIREIEATGLQTKEELKIAHIHLKEHQET 1250

Query: 679  IGINKKSVKSA-----------KDGTSPEEEIEIERQKAEMALLMMDEDEDSKKHFNYNK 727
            I   ++SV              K  T  +EEI +  ++ E+ L  + E  ++++  N  +
Sbjct: 1251 IDELRRSVSEKTAQIINTQDLEKSHTKLQEEIPVLHEEQEL-LPNVKEVSETQETMNELE 1309

Query: 728  IVEHQNLSKKKKK--QLMKKKELIEDDFEVNVNDARFQAMYTSHLFNL--------DPSD 777
            ++  Q+ +K      ++  ++  + + F+ +  + +       +L  +        D   
Sbjct: 1310 LLTEQSTTKDSTTLARIEMERLRLNEKFQESQEEIKSLTKERDNLKTIKEALEVKHDQLK 1369

Query: 778  PNFKKTKAMEKILEEKARQRE-----RKEQELTQAIKKKESEIEKESQRKSIDPALSMLI 832
             + ++T A  KI E +++Q +      K+ E T+ + + E    K+S    I+  +  L 
Sbjct: 1370 EHIRETLA--KIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSALLRIEIEMLGLS 1427

Query: 833  KSIKTKTEQFQARKKQK 849
            K ++   ++ ++  K+K
Sbjct: 1428 KRLQESHDEMKSVAKEK 1444



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 73/319 (22%), Positives = 133/319 (41%), Gaps = 44/319 (13%)

Query: 546 DEEEIEEELQG--DDGVNVEEDGKTKKSQKDDEEQIAKYRQLL---QVIQEKEKKGKEND 600
           ++E IE EL     D  N+  D +  +++K++ E   K +  L   + ++ K KK +E  
Sbjct: 492 NQENIESELNSLRADYDNLVLDYEQLRTEKEEMELKLKEKNDLDEFEALERKTKKDQEMQ 551

Query: 601 MEMEIKWVPGLKESAE---EMVKNKLEGKDKLTPWEQFLEKKKEKKRLKRKQKALAEEAS 657
           +  EI  +  L + AE   + ++N+L  K +L       EK+ + K+L+    +   E  
Sbjct: 552 LIHEISNLKNLVKHAEVYNQDLENELSSKVEL-----LREKEDQIKKLQEYIDSQKLENI 606

Query: 658 EEELPSDVD-LNDPYFAEEVKQIGINKKSVKSAKDGTSP---EEEIEIERQKAEMALLMM 713
           + +L   ++ + DP   +++KQ   + ++V       S     E +E++ +  E+A    
Sbjct: 607 KMDLSYSLESIEDP---KQMKQTLFDAETVALDAKRESAFLRSENLELKEKMKELATTYK 663

Query: 714 DEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQAMYTSHLF-N 772
             + D + +           L  KKK Q+  +KEL     E+    +         L  N
Sbjct: 664 QMENDIQLY--------QSQLEAKKKMQVDLEKELQSAFNEITKLTSLIDGKVPKDLLCN 715

Query: 773 LDPSDPNFKKTKAMEKILEEKARQRERKEQELTQAIKKKESEIEKESQRKSIDPALSMLI 832
           L+         K + K +EE    RE  E  L   +K   SE+E+             L 
Sbjct: 716 LELEGKITDLQKELNKEVEENEALRE--EVILLSELKSLPSEVER-------------LR 760

Query: 833 KSIKTKTEQFQARKKQKVK 851
           K I+ K+E+      +K K
Sbjct: 761 KEIQDKSEELHIITSEKDK 779



 Score = 40.8 bits (94), Expect = 0.005
 Identities = 58/259 (22%), Positives = 116/259 (44%), Gaps = 23/259 (8%)

Query: 498  TSAAMGTSTVEITWDETDHERITMLNRKFKKEELLDMDFQAYLASSSEDEEE-----IEE 552
            TS A G   V  T  +  +  +T    +   E++ +++   + A  S   +E     +++
Sbjct: 2351 TSLASGAQ-VNPTTQDNKNPHVTSRATQLTTEKIRELENSLHEAKESAMHKESKIIKMQK 2409

Query: 553  ELQGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKG----KENDMEMEIKWV 608
            EL+  + +  +   K  +S K  E    K ++ +QV+Q+K   G    KE   ++++K V
Sbjct: 2410 ELEVTNDIIAKLQAKVHESNKCLE----KTKETIQVLQDKVALGAKPYKEEIEDLKMKLV 2465

Query: 609  PGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASEEELPSD---- 664
               K   E+M KN  E + +++  +  +E +KE  RL R+    +++A +  + S+    
Sbjct: 2466 ---KIDLEKM-KNAKEFEKEISATKATVEYQKEVIRLLRENLRRSQQAQDTSVISEHTDP 2521

Query: 665  VDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDEDSKKHF- 723
               N P        I  N K++    +    E+EI   +Q+ E  +   +E   + +H  
Sbjct: 2522 QPSNKPLTCGGGSGIVQNTKALILKSEHIRLEKEISKLKQQNEQLIKQKNELLSNNQHLS 2581

Query: 724  NYNKIVEHQNLSKKKKKQL 742
            N  K  + + L ++  KQ+
Sbjct: 2582 NEVKTWKERTLKREAHKQV 2600



 Score = 37.7 bits (86), Expect = 0.045
 Identities = 139/776 (17%), Positives = 308/776 (39%), Gaps = 90/776 (11%)

Query: 93   KIKKKKTQTKKEIDSKNLVEKKKE--TKKANHKGSENKTDLDNSIGIKKMKTSCKFKIDS 150
            ++++ K Q +    +   VE++K   T+K      E KT       +K+++ S + + D 
Sbjct: 888  EMEQLKEQLENRDSTLQTVEREKTLITEKLQQTLEEVKTLTQEKDDLKQLQESLQIERDQ 947

Query: 151  NISPKKDSKEFTQKNKKEKKNIVQHTTDSSLEEKQRTLDSGTS----EIVKSPRIE--CS 204
              S   D+       +++ +N ++     SL++ Q T+++  S    E+ ++  +E    
Sbjct: 948  LKSDIHDTVNMNIDTQEQLRNALE-----SLKQHQETINTLKSKISEEVSRNLHMEENTG 1002

Query: 205  KTRREMQS-VVQLIMTRDSDGYENST-DGEMCDKDALEEDSESVSEIGSDEESENEITSV 262
            +T+ E Q  +V +   +D +     T   ++ D + +E+  +  S I    E +  + SV
Sbjct: 1003 ETKDEFQQKMVGIDKKQDLEAKNTQTLTADVKDNEIIEQQRKIFSLIQEKNELQQMLESV 1062

Query: 263  GRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDSGPDLARGKGNIETSSEDE-DDTAD 321
               +  +    D +E  E   E+++E     D+     ++   + N     E E   T D
Sbjct: 1063 --IAEKEQLKTDLKENIEMTIENQEELRLLGDELKKQQEIVAQEKNHAIKKEGELSRTCD 1120

Query: 322  LFPEESGFEHAWRELDKDAPRADEITRRLAVCNMDWDRLKAK--DLLALFNSFKPKGGVI 379
               E         +L + + +  E  ++L     +   ++ K  ++  L N  K K   +
Sbjct: 1121 RLAEVE------EKLKEKSQQLQEKQQQLLNVQEEMSEMQKKINEIENLKNELKNKELTL 1174

Query: 380  FSVKIYPSEFGKERMKE-EQVQGPVELLSIPEDAPEKDWTSREKLRDYQFKRLKYYYAVV 438
              ++    E  ++  +  E+V+   +   + ++  +   T R+ LR Y            
Sbjct: 1175 EHMETERLELAQKLNENYEEVKSITKERKVLKELQKSFETERDHLRGY------------ 1222

Query: 439  DCDSPETASKIYE-DCDGLEFESSCSFIDLRFIPDDITFDDEPKDVASEVNLTAYKPKYF 497
                      I E +  GL+ +       +       T D+  + V+ +           
Sbjct: 1223 ----------IREIEATGLQTKEELKIAHIHLKEHQETIDELRRSVSEK----------- 1261

Query: 498  TSAAMGTSTVEITWDETDHERITMLNRKFKKEELLDMDFQAYLASSSEDEEEIEE-ELQG 556
            T+  + T  +E +  +   E I +L+   +++ELL       +   SE +E + E EL  
Sbjct: 1262 TAQIINTQDLEKSHTKLQEE-IPVLH---EEQELLPN-----VKEVSETQETMNELEL-- 1310

Query: 557  DDGVNVEEDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEME-IKWVPGLKESA 615
                 + E   TK S      ++ + R L +  QE +++ K    E + +K +    E  
Sbjct: 1311 -----LTEQSTTKDSTTLARIEMERLR-LNEKFQESQEEIKSLTKERDNLKTIKEALEVK 1364

Query: 616  EEMVKNKLEGKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASEEEL--PSDVDLNDPYFA 673
             + +K  +  ++ L   ++   K+++   +K K     +  SE E   P D  L      
Sbjct: 1365 HDQLKEHI--RETLAKIQESQSKQEQSLNMKEKDNETTKIVSEMEQFKPKDSAL----LR 1418

Query: 674  EEVKQIGINKKSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDEDSKKHFNYNKIVEHQN 733
             E++ +G++K+  +S  +  S  +E +  ++  E+     D+ +++ K      +   + 
Sbjct: 1419 IEIEMLGLSKRLQESHDEMKSVAKEKDDLQRLQEVLQSESDQLKENIKEIVAKHLETEEE 1478

Query: 734  LSKKKKKQLMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKAMEKILEEK 793
            L  K     +K++E   ++  VN+++   +                 K  +  EK  +  
Sbjct: 1479 L--KVAHCCLKEQEETINELRVNLSEKETEISTIQKQLEAINDKLQNKIQEIYEKEEQFN 1536

Query: 794  ARQRERKEQELTQAIKKKESEIEKESQRKSIDPALSMLIKSIKTKTEQFQARKKQK 849
             +Q    ++++ +  + KE    K+S  +SI+  +  L   ++   E+ Q   K+K
Sbjct: 1537 IKQISEVQEKVNELKQFKEHRKAKDSALQSIESKMLELTNRLQESQEEIQIMIKEK 1592


>gi|41406064 myosin, heavy polypeptide 10, non-muscle [Homo sapiens]
          Length = 1976

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 166/870 (19%), Positives = 328/870 (37%), Gaps = 134/870 (15%)

Query: 74   LSDSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKK--KETKKANHKGSENKTDL 131
            +++  S L+ E+ KA +  KI+ K+     +++ +   E+K  +E +KA  K     TDL
Sbjct: 1008 IAECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAKRKLDGETTDL 1067

Query: 132  DNSIG-----IKKMKTS-CKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSSLEEKQ 185
             + I      I ++K    K + +   +  +   E   KN   K   V     + + E Q
Sbjct: 1068 QDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALK---VVRELQAQIAELQ 1124

Query: 186  RTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKDALEEDSES 245
               +S      K+ R +  K +R++   ++ + T      E++ D     ++   +  + 
Sbjct: 1125 EDFES-----EKASRNKAEKQKRDLSEELEALKTE----LEDTLDTTAAQQELRTKREQE 1175

Query: 246  VSEI--GSDEESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDSGPDLA 303
            V+E+    +EE++N    +          +D  +      E+  E  E            
Sbjct: 1176 VAELKKALEEETKNHEAQI----------QDMRQRHATALEELSEQLE---------QAK 1216

Query: 304  RGKGNIETSSED-EDDTADLFPEESGFEHAWRELDKDAPRADEITRRLAVCNMDWDRLK- 361
            R K N+E + +  E D  +L  E    +    E +    + D   + L     + DRL+ 
Sbjct: 1217 RFKANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQELHAKVSEGDRLRV 1276

Query: 362  --AKDLLALFNSFKPKGGVIFSVKIYPSEFGKERMK-EEQVQGPVELLS----------- 407
              A+    L N       ++   +    +F K+    E Q+Q   ELL            
Sbjct: 1277 ELAEKASKLQNELDNVSTLLEEAEKKGIKFAKDAASLESQLQDTQELLQEETRQKLNLSS 1336

Query: 408  -IPEDAPEKDWTSREKLRDYQF-KRLKYYYAVVDCDSPETASKIYEDCDGLEFESSCSFI 465
             I +   EK+    ++  + +  K L+     +     +T  K+ +D   +E        
Sbjct: 1337 RIRQLEEEKNSLQEQQEEEEEARKNLEKQVLALQSQLADTKKKVDDDLGTIE-------- 1388

Query: 466  DLRFIPDDITFDDEPKDVASEVNLTAYKPKYFTSAAMGTSTVEITWDETDHER--ITMLN 523
             L      +  D E      E    AY     T   +     ++T D  DH+R   + L 
Sbjct: 1389 SLEEAKKKLLKDAEALSQRLEEKALAYDKLEKTKNRLQQELDDLTVD-LDHQRQVASNLE 1447

Query: 524  RKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKTKKSQKDDEEQIAKYR 583
            +K KK + L  + ++  A  +E+ +  E E +  +   +      +++ +  EE   + +
Sbjct: 1448 KKQKKFDQLLAEEKSISARYAEERDRAEAEAREKETKALSLARALEEALEAKEEFERQNK 1507

Query: 584  QLL----QVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKLEGKDKLTPWE------ 633
            QL      ++  K+  GK N  E+E K    L++  EEM     E +D+L   E      
Sbjct: 1508 QLRADMEDLMSSKDDVGK-NVHELE-KSKRALEQQVEEMRTQLEELEDELQATEDAKLRL 1565

Query: 634  ---------QFL-------EKKKEKKRL--------------KRKQKALA------EEAS 657
                     QF        E+ +EKKRL              +RKQ+ALA       E  
Sbjct: 1566 EVNMQAMKAQFERDLQTRDEQNEEKKRLLIKQVRELEAELEDERKQRALAVASKKKMEID 1625

Query: 658  EEELPSDVDLNDPYFAEEVKQIGINKKSVK-----------SAKDGTSPEEEIEIERQKA 706
             ++L + ++  +    E +KQ+   +  +K           S  +  +  +E E + +  
Sbjct: 1626 LKDLEAQIEAANKARDEVIKQLRKLQAQMKDYQRELEEARASRDEIFAQSKESEKKLKSL 1685

Query: 707  EMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQAMY 766
            E  +L + E+  S +    +   E   L+ +       K  L+++   +    A+ +   
Sbjct: 1686 EAEILQLQEELASSERARRHAEQERDELADEITNSASGKSALLDEKRRLEARIAQLEEEL 1745

Query: 767  TSHLFNLDPSDPNFKKTKAMEKILEEK---ARQRERKEQELTQAIKKKESEIEKESQ--R 821
                 N++  +  F+KT      L  +    R   +K     Q ++++  E++ + Q   
Sbjct: 1746 EEEQSNMELLNDRFRKTTLQVDTLNAELAAERSAAQKSDNARQQLERQNKELKAKLQELE 1805

Query: 822  KSIDPALSMLIKSIKTKTEQFQARKKQKVK 851
             ++       I +++ K  Q + + +Q+ K
Sbjct: 1806 GAVKSKFKATISALEAKIGQLEEQLEQEAK 1835



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 68/346 (19%), Positives = 141/346 (40%), Gaps = 28/346 (8%)

Query: 512  DETDHERITMLNRKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKTKKS 571
            +E  H+  + +  + ++ ++L  + +   A   + EE+++EE      + +E+     K 
Sbjct: 921  EEILHDLESRVEEEEERNQILQNEKKKMQAHIQDLEEQLDEEEGARQKLQLEKVTAEAKI 980

Query: 572  QKDDEEQIAKYRQLLQVIQEK--------EKKGKENDMEMEIKWVPGLKESAEEMVKNKL 623
            +K +EE +    Q  + I+EK        E   +  + E + K +  ++   E M+ +  
Sbjct: 981  KKMEEEILLLEDQNSKFIKEKKLMEDRIAECSSQLAEEEEKAKNLAKIRNKQEVMISDLE 1040

Query: 624  EGKDKLTPWEQFLEKKKEK---------KRLKRKQKALAE-----EASEEELPSDVDLND 669
            E   K     Q LEK K K          ++   Q  + E        EEEL   +   D
Sbjct: 1041 ERLKKEEKTRQELEKAKRKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQGALARGD 1100

Query: 670  PYFAEEVKQIGINKKSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDEDSKK---HFNYN 726
                 +   + + ++      +     E  +  R KAE     + E+ ++ K       +
Sbjct: 1101 DETLHKNNALKVVRELQAQIAELQEDFESEKASRNKAEKQKRDLSEELEALKTELEDTLD 1160

Query: 727  KIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKAM 786
                 Q L  K+++++ + K+ +E+  E   ++A+ Q M   H   L+      ++ K  
Sbjct: 1161 TTAAQQELRTKREQEVAELKKALEE--ETKNHEAQIQDMRQRHATALEELSEQLEQAKRF 1218

Query: 787  EKILEEKARQRERKEQELTQAIK-KKESEIEKESQRKSIDPALSML 831
            +  LE+  +  E   +EL   +K  ++ + E E +RK +D  +  L
Sbjct: 1219 KANLEKNKQGLETDNKELACEVKVLQQVKAESEHKRKKLDAQVQEL 1264



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 67/276 (24%), Positives = 123/276 (44%), Gaps = 36/276 (13%)

Query: 573  KDDEEQIAKYRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKLEGKDKLTPW 632
            + +EE  AK  +LL+V +EK+ K +    EME K    L+E  + ++  +L+ + +L   
Sbjct: 849  RQEEELQAKDEELLKV-KEKQTKVEGELEEMERKHQQLLEE--KNILAEQLQAETEL--- 902

Query: 633  EQFLEKKKEKKRLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGINKKSVKSAKDG 692
              F E ++ + RL  K++ L E   + E   + +       EE  QI  N+K    A   
Sbjct: 903  --FAEAEEMRARLAAKKQELEEILHDLESRVEEE-------EERNQILQNEKKKMQAHIQ 953

Query: 693  TSPEEEIEIERQKAEMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKELIEDD 752
               E+  E E  + ++ L  +  +   KK      ++E QN       + +K+K+L+ED 
Sbjct: 954  DLEEQLDEEEGARQKLQLEKVTAEAKIKKMEEEILLLEDQN------SKFIKEKKLMEDR 1007

Query: 753  FEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKAMEKI----LEEKARQRERKEQELTQAI 808
                       A  +S L   +    N  K +  +++    LEE+ ++ E+  QEL +A 
Sbjct: 1008 I----------AECSSQLAEEEEKAKNLAKIRNKQEVMISDLEERLKKEEKTRQELEKAK 1057

Query: 809  KKKESE-IEKESQRKSIDPALSMLIKSIKTKTEQFQ 843
            +K + E  + + Q   +   +  L   +  K E+ Q
Sbjct: 1058 RKLDGETTDLQDQIAELQAQIDELKLQLAKKEEELQ 1093



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 71/345 (20%), Positives = 152/345 (44%), Gaps = 24/345 (6%)

Query: 517  ERITMLNRKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKTKKSQKDDE 576
            E   +L  + + E  L  + +   A  +  ++E+EE L   +    EE+ + +  Q + +
Sbjct: 887  EEKNILAEQLQAETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQILQNEKK 946

Query: 577  EQIAKYRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMV----KNKLEGKDKLTPW 632
            +  A  + L + + E+E   ++  +E ++     +K+  EE++    +N    K+K    
Sbjct: 947  KMQAHIQDLEEQLDEEEGARQKLQLE-KVTAEAKIKKMEEEILLLEDQNSKFIKEKKLME 1005

Query: 633  EQFLEKKKEKKRLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGINKKSVKSAKDG 692
            ++  E   +    + K K LA+  +++E+    DL +    EE  +  + K   K   + 
Sbjct: 1006 DRIAECSSQLAEEEEKAKNLAKIRNKQEVMIS-DLEERLKKEEKTRQELEKAKRKLDGET 1064

Query: 693  TSPEEEI-EIERQKAEMALLMMDEDEDSKKHF-NYNKIVEHQNLSKKKKKQLMKKKELIE 750
            T  +++I E++ Q  E+ L +  ++E+ +      +    H+N + K  ++L  +   ++
Sbjct: 1065 TDLQDQIAELQAQIDELKLQLAKKEEELQGALARGDDETLHKNNALKVVRELQAQIAELQ 1124

Query: 751  DDFE---VNVNDARFQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKARQRE---RKEQEL 804
            +DFE    + N A  Q          D S+        +E  L+  A Q+E   ++EQE+
Sbjct: 1125 EDFESEKASRNKAEKQ--------KRDLSEELEALKTELEDTLDTTAAQQELRTKREQEV 1176

Query: 805  TQAIKKKESEIEKESQRKSIDPALSMLIKSIKTKTEQFQARKKQK 849
             +   KK  E E ++    I         +++  +EQ +  K+ K
Sbjct: 1177 AEL--KKALEEETKNHEAQIQDMRQRHATALEELSEQLEQAKRFK 1219



 Score = 30.8 bits (68), Expect = 5.6
 Identities = 21/103 (20%), Positives = 49/103 (47%), Gaps = 3/103 (2%)

Query: 725 YNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTK 784
           + K+     +++++++   K +EL++   +    +   + M   H   L+  +   ++ +
Sbjct: 838 FTKVKPLLQVTRQEEELQAKDEELLKVKEKQTKVEGELEEMERKHQQLLEEKNILAEQLQ 897

Query: 785 AMEKILEEKARQRER---KEQELTQAIKKKESEIEKESQRKSI 824
           A  ++  E    R R   K+QEL + +   ES +E+E +R  I
Sbjct: 898 AETELFAEAEEMRARLAAKKQELEEILHDLESRVEEEEERNQI 940


>gi|51477718 TATA box binding protein-associated factor, RNA
           polymerase II, Q [Homo sapiens]
          Length = 462

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 43/148 (29%), Positives = 76/148 (51%), Gaps = 12/148 (8%)

Query: 164 KNKKEKKNIVQHTTDSSLEEKQRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSD 223
           KN ++K+      T   + + +    S  +E ++SP +E ++ +R ++S  + + TR   
Sbjct: 227 KNVRKKRF---RKTQKKVPDVKEMEKSSFTEYIESPDVE-NEVKRLLRSDAEAVSTRWEV 282

Query: 224 GYENSTDGEMCDKDALEE-------DSESVSEIGSDEESENEITSVGRASGDDDGSEDDE 276
             E+ T  E+  + ++          S       S+ +   E+ S  R++ DDD  EDDE
Sbjct: 283 IAEDGTK-EIESQGSIPGFLISSGMSSHKQGHTSSEYDMLREMFSDSRSNNDDDEDEDDE 341

Query: 277 EEDEDEEEDEDEDSEDDDKSDSGPDLAR 304
           +EDEDE+EDEDED E++++  S   L R
Sbjct: 342 DEDEDEDEDEDEDKEEEEEDCSEEYLER 369



 Score = 36.6 bits (83), Expect = 0.10
 Identities = 37/150 (24%), Positives = 62/150 (41%), Gaps = 10/150 (6%)

Query: 155 KKDSKEFTQKNKKEKKNIVQHTTDSSLE-EKQRTLDSGTSEIVKSPRIECSKTRREMQSV 213
           +K  K+     + EK +  ++     +E E +R L S    +     +      +E++S 
Sbjct: 235 RKTQKKVPDVKEMEKSSFTEYIESPDVENEVKRLLRSDAEAVSTRWEVIAEDGTKEIESQ 294

Query: 214 VQLIMTRDSDGYENSTDGEMCDK-DALEE---DSESVSEIGSDEESENEITSVGRASGDD 269
             +     S G  +   G    + D L E   DS S ++   DE+ E+E         D+
Sbjct: 295 GSIPGFLISSGMSSHKQGHTSSEYDMLREMFSDSRSNNDDDEDEDDEDE-----DEDEDE 349

Query: 270 DGSEDDEEEDEDEEEDEDEDSEDDDKSDSG 299
           D  ED EEE+ED  E+  E     +  +SG
Sbjct: 350 DEDEDKEEEEEDCSEEYLERQLQAEFIESG 379



 Score = 33.5 bits (75), Expect = 0.86
 Identities = 52/253 (20%), Positives = 99/253 (39%), Gaps = 32/253 (12%)

Query: 618 MVKNKLEGKDKLTPWEQFLE---KKKEKKRLKRKQKALAEEASEEELPSDVDLNDPYFAE 674
           +V+ K  G+++   W+  +    K   KKR ++ QK + +    E+      +  P    
Sbjct: 204 IVRKKERGREEKCVWKHGITPPLKNVRKKRFRKTQKKVPDVKEMEKSSFTEYIESPDVEN 263

Query: 675 EVKQI------GINKKSVKSAKDGTSPEEEIEIERQKAEMALLM---MDEDEDSKKHFNY 725
           EVK++       ++ +    A+DGT      EIE Q +    L+   M   +       Y
Sbjct: 264 EVKRLLRSDAEAVSTRWEVIAEDGTK-----EIESQGSIPGFLISSGMSSHKQGHTSSEY 318

Query: 726 NKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKA 785
           + + E  + S+        + +  ED+ E    D   +          D S+   ++   
Sbjct: 319 DMLREMFSDSRSNNDDDEDEDDEDEDEDEDEDEDEDKEEE------EEDCSEEYLERQLQ 372

Query: 786 MEKILEEKARQRERKE---QELTQAIKKKESEIEKESQRKSIDPALSMLIKSIKTKT--- 839
            E I   + R  E       E+ + I+KKE ++ K   +      L M ++++  K    
Sbjct: 373 AEFIESGQYRANEGTSSIVMEIQKQIEKKEKKLHKIQNKAQRQKDLIMKVENLTLKNHFQ 432

Query: 840 ---EQFQARKKQK 849
              EQ + ++KQK
Sbjct: 433 SVLEQLELQEKQK 445



 Score = 31.6 bits (70), Expect = 3.3
 Identities = 37/148 (25%), Positives = 63/148 (42%), Gaps = 22/148 (14%)

Query: 205 KTRREMQSVVQLIMTRDSDGYENSTDGEMCDKDALEEDSESVS-------EIGSDE-ESE 256
           KT++++  V ++  +  ++ Y  S D E   K  L  D+E+VS       E G+ E ES+
Sbjct: 236 KTQKKVPDVKEMEKSSFTE-YIESPDVENEVKRLLRSDAEAVSTRWEVIAEDGTKEIESQ 294

Query: 257 NEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDS-----EDDDKSDSGPDLARGKGNIET 311
             I     +SG     +     + D   +   DS     +D+D+ D   D        E 
Sbjct: 295 GSIPGFLISSGMSSHKQGHTSSEYDMLREMFSDSRSNNDDDEDEDDEDED--------ED 346

Query: 312 SSEDEDDTADLFPEESGFEHAWRELDKD 339
             EDED+  +   E+   E+  R+L  +
Sbjct: 347 EDEDEDEDKEEEEEDCSEEYLERQLQAE 374



 Score = 30.4 bits (67), Expect = 7.3
 Identities = 93/453 (20%), Positives = 169/453 (37%), Gaps = 75/453 (16%)

Query: 245 SVSEIGSDEESENEI---TSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDSGPD 301
           S SE+ S +E +  +   +     S  D   ++  +   DE+   D DS     + +  +
Sbjct: 21  STSEVTSQQEPQIPVDRGSETTYESSADIAGDEGTQIPADEDTQTDADSSAQAAAQAPEN 80

Query: 302 LARGKGNIETSSEDEDDTADLFPEESGFEHAWRELD---------KDAPRADEITR-RLA 351
              GK   E+  E  D+  + F      EHA    +         KD  + D +   R A
Sbjct: 81  FQEGKDMSESQDEVPDEVENQFILRLPLEHACTVRNLARSQSVKMKDKLKIDLLPDGRHA 140

Query: 352 VCNMDWDRLKAK--DLLALFNSFKPKGGVIF------SVKIYPSEFGKERMKEEQVQGPV 403
           V  ++   L AK  DL  +  S +      F      S  +  +  G   +  E+     
Sbjct: 141 VVEVEDVPLAAKLVDLPCVIESLRTLDKKTFYKTADISQMLVCTADGDIHLSPEEPAAST 200

Query: 404 ELLSIPEDAPEKDWTSREK----------LRDYQFKRL-KYYYAVVDCDSPETASKI-YE 451
           +    P    +K+    EK          L++ + KR  K    V D    E +S   Y 
Sbjct: 201 D----PNIVRKKERGREEKCVWKHGITPPLKNVRKKRFRKTQKKVPDVKEMEKSSFTEYI 256

Query: 452 DCDGLEFE------SSCSFIDLRFIPDDITFDDEPKDVASEVNLTAYKPKYFTSAAMGTS 505
           +   +E E      S    +  R+   ++  +D  K++ S+ ++    P +  S+ M + 
Sbjct: 257 ESPDVENEVKRLLRSDAEAVSTRW---EVIAEDGTKEIESQGSI----PGFLISSGMSSH 309

Query: 506 TVEITWDETDHERITMLNRKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEED 565
               T  E D  R    + +   ++  D D         EDE+E E+E         +ED
Sbjct: 310 KQGHTSSEYDMLREMFSDSRSNNDDDEDED--------DEDEDEDEDE---------DED 352

Query: 566 GKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKE--NDMEMEIKWVPGLKESAEEMVKNKL 623
              ++ ++D  E+  + +   + I+  + +  E  + + MEI+     KE     ++NK 
Sbjct: 353 EDKEEEEEDCSEEYLERQLQAEFIESGQYRANEGTSSIVMEIQKQIEKKEKKLHKIQNKA 412

Query: 624 EGKDKLTPWEQFLEKKK------EKKRLKRKQK 650
           + +  L    + L  K       E+  L+ KQK
Sbjct: 413 QRQKDLIMKVENLTLKNHFQSVLEQLELQEKQK 445


>gi|34577114 cytomatrix protein p110 [Homo sapiens]
          Length = 957

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 75/322 (23%), Positives = 134/322 (41%), Gaps = 45/322 (13%)

Query: 548 EEIEEELQGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEMEIKW 607
           E ++E+ + DD   +EE    +K  KD +E++     L   + EKE              
Sbjct: 598 ERLKEQRERDDRERLEEIESFRKENKDLKEKV---NALQAELTEKESS------------ 642

Query: 608 VPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASEEELPSDVDL 667
           +  LKE A  +    L+   KL   E  +E+KKE+       K  A+      +  D  +
Sbjct: 643 LIDLKEHASSLASAGLKRDSKLKSLEIAIEQKKEEC-----SKLEAQLKKAHNIEDDSRM 697

Query: 668 NDPYFAEEVKQIGINKKSVKSAKDGTSPEEEI--------EIERQK-------AEMALLM 712
           N P FA+++KQ+  +K++     +    + E+        E+E +K       AE+  L 
Sbjct: 698 N-PEFADQIKQL--DKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKIAELESLT 754

Query: 713 MDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQAMYTSHLFN 772
           +   +D  K      +  +Q L KKK  QL+++    ED    N    + + +  +    
Sbjct: 755 LRHMKDQNK--KVANLKHNQQLEKKKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKT 812

Query: 773 LDPSDPNFKKTKAMEKILEEK----ARQRERKEQELTQAIKKKESEIEKESQRKSIDPAL 828
               D    +  + ++ L EK    A  R  + ++L + ++ K+  +      K  + AL
Sbjct: 813 RQELDATKARLASTQQSLAEKEAHLANLRIERRKQLEEILEMKQEALLAAISEKDANIAL 872

Query: 829 SMLIKSIKTKT-EQFQARKKQK 849
             L  S K KT E+  A K++K
Sbjct: 873 LELSASKKKKTQEEVMALKREK 894



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 59/300 (19%), Positives = 121/300 (40%), Gaps = 49/300 (16%)

Query: 548 EEIEEELQGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEMEIKW 607
           E ++E+L+  D        + K  Q D          L + + EKE+             
Sbjct: 549 ENLQEQLRDKDKQLTNLKDRVKSLQTDSSNTDTALATLEEALSEKERI------------ 596

Query: 608 VPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASEEELPSDVDL 667
           +  LKE  E       + +++L   E F   +KE K LK K  AL  E +E+E  S +DL
Sbjct: 597 IERLKEQRER------DDRERLEEIESF---RKENKDLKEKVNALQAELTEKE-SSLIDL 646

Query: 668 NDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDE--------DS 719
            +   A  +   G+ + S   + +    +++ E  + +A++      ED+        D 
Sbjct: 647 KE--HASSLASAGLKRDSKLKSLEIAIEQKKEECSKLEAQLKKAHNIEDDSRMNPEFADQ 704

Query: 720 KKHFNYNKIVEHQNLSKKKKK-----QLMKKKELIEDDFEVNVNDARFQAMYTSHLFNLD 774
            K  +           K + +     +++K+ E  ++D +  +  A  +++   H+ + +
Sbjct: 705 IKQLDKEASYYRDECGKAQAEVDRLLEILKEVENEKNDKDKKI--AELESLTLRHMKDQN 762

Query: 775 PSDPNFKKTKAMEKILEEKARQRERKEQELTQAIKKKESEIEKESQRKSIDPALSMLIKS 834
               N K  + +EK          +K  +L + ++++E  +   SQ   I+  ++ L K+
Sbjct: 763 KKVANLKHNQQLEK----------KKNAQLLEEVRRREDSMADNSQHLQIEELMNALEKT 812


>gi|104526627 triadin [Homo sapiens]
          Length = 729

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 79/347 (22%), Positives = 147/347 (42%), Gaps = 34/347 (9%)

Query: 522 LNRKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDG-KTKKSQKDDEEQIA 580
           + +K K E       Q    ++ + EE+ ++E++G     V++   K K+ QK   +   
Sbjct: 190 IEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKE 249

Query: 581 KYRQLLQVIQEKEKKGKENDMEMEIK-WVPG-LKESAEEMVKNKL--EGKDKLTPWEQFL 636
           K  +    + + E+K +       I  +V G LK      +   L  E   + TP    L
Sbjct: 250 KEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPAL 309

Query: 637 EKKKEKKR---------LKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGINKKSVK 687
           E+K+ +K+          K+K+K   ++ SE+E   DV+  +P  A E KQ G  K + +
Sbjct: 310 EEKEGEKKKAEKKVTSETKKKEKEDIKKKSEKETAIDVEKKEPGKASETKQ-GTVKIAAQ 368

Query: 688 SAKDGTSPEEEIEIERQKAEMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKE 747
           +A      +E+ +  ++ AE+      + E  +KH    K  + ++     K+   K + 
Sbjct: 369 AAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTER 428

Query: 748 LIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKARQRERKEQELTQA 807
             E+   V++  A              P     K TK +E+ + ++   +     +  + 
Sbjct: 429 AKEEIGAVSIKKA-------------VPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEP 475

Query: 808 IKKKESEI-----EKESQRKSIDPALSMLIKSIKTKTEQFQARKKQK 849
           IK KE ++     EKE + K  D  +S   K +K K  Q Q +K++K
Sbjct: 476 IKGKEEKVPASLKEKEPETKK-DEKMSKAGKEVKPKPPQLQGKKEEK 521



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 87/363 (23%), Positives = 145/363 (39%), Gaps = 66/363 (18%)

Query: 543 SSEDEEEIEEELQGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLLQ--VIQEKEKKGKEND 600
           SSEDEE+ + +   D G   E   + K+  KD  E+  K  + +Q  V  ++++KGKE  
Sbjct: 115 SSEDEEDDDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEKPERKIQTKVTHKEKEKGKEKV 174

Query: 601 MEMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKRLKRKQ----------K 650
            E E    P  K + +E ++ K + + K    EQ   K  EK   K K+          K
Sbjct: 175 REKE---KPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKSEEKTKKEVKGGKQEKVK 231

Query: 651 ALAEEASE-EELPSDVDLNDPYFAEEVKQIGINKKSVKSA----------------KDGT 693
             A +  E ++ PS      P   E+ ++  ++K   K                  K G 
Sbjct: 232 QTAAKVKEVQKTPSK-----PKEKEDKEKAAVSKHEQKDQYAFCRYMIDIFVHGDLKPGQ 286

Query: 694 SPEEEIEIERQKAEM---ALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKELIE 750
           SP     +  ++A     A   ++E E  KK        E    +KKK+K+ +KKK   E
Sbjct: 287 SPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSE----TKKKEKEDIKKKSEKE 342

Query: 751 DDFEVNVNDARFQAMYTSHLFNL--------DPSDPNFKKTKAMEKILEEKARQRERKEQ 802
              +V   +    +        +        D    + KKTK   ++ + K +++E+KE+
Sbjct: 343 TAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKTKKPAEVEQPKGKKQEKKEK 402

Query: 803 ELTQAIK-KKESEIEKESQRK-------------SIDPALSMLIKSIKTKTEQFQARKKQ 848
            +  A   KKE  +  + Q K             SI  A+    +   TKT + + RK++
Sbjct: 403 HVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEK 462

Query: 849 KVK 851
             K
Sbjct: 463 SGK 465



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 116/630 (18%), Positives = 241/630 (38%), Gaps = 76/630 (12%)

Query: 243 SESVSEIGSD---------EESENEITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDD 293
           + S+++IGSD         EE+ + I        D   SED+E++D DE+ D+ E  E  
Sbjct: 78  ASSIAKIGSDPLKLVRDAMEETTDWIYGFFSLLSDIISSEDEEDDDGDEDTDKGEIDE-- 135

Query: 294 DKSDSGPDLARGKGNIETSSEDEDDTADLFPEESGFEHAWRELDKDAPRADEITRRLAVC 353
                 P L + + + + + + E     +   ++   H  +E  K+  R  E   + A  
Sbjct: 136 ------PPLRKKEIHKDKTEKQEKPERKI---QTKVTHKEKEKGKEKVREKEKPEKKATH 186

Query: 354 NMDWDRLKAKDLLALFNSFKPKGGVIFSVKIYPSEFGKERMKEEQVQGPVELLSIPEDAP 413
               ++ +  +   L    K         K   +E  +E+ K+E   G  E +       
Sbjct: 187 KEKIEKKEKPETKTLAKEQK---------KAKTAEKSEEKTKKEVKGGKQEKVKQTAAKV 237

Query: 414 EKDWTSREKLRDYQFKRLKYYYAVVDCDSPETASKIYEDCDGLEFESSCSFIDLRFIPDD 473
           ++   +  K ++ +             D  + A   +E  D   F   C ++   F+  D
Sbjct: 238 KEVQKTPSKPKEKE-------------DKEKAAVSKHEQKDQYAF---CRYMIDIFVHGD 281

Query: 474 ITFDDEPKDVASEVNLTAYKPKYFTSAAMGTSTVEITWDETDHER------ITMLNRKFK 527
           +     P          A  P   T  A   +      +E + E+      +T   +K +
Sbjct: 282 LKPGQSP----------AIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSETKKKE 331

Query: 528 KEELLDM-DFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLL 586
           KE++    + +  +    ++  +  E  QG   V +      KK +K ++ +  K ++  
Sbjct: 332 KEDIKKKSEKETAIDVEKKEPGKASETKQGT--VKIAAQAAAKKDEKKEDSK--KTKKPA 387

Query: 587 QVIQEKEKKGKENDMEMEIKWVPGLKES--AEEMVKNKLE-GKDKL--TPWEQFLEKKKE 641
           +V Q K KK ++ +  +E    P  + S  +++ VK K E  K+++     ++ +  KKE
Sbjct: 388 EVEQPKGKKQEKKEKHVEPAKSPKKEHSVPSDKQVKAKTERAKEEIGAVSIKKAVPGKKE 447

Query: 642 KKRLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIEI 701
           +K  K  ++ + +E S +      D       EE     + +K  ++ KD    +   E+
Sbjct: 448 EKTTKTVEQEIRKEKSGKTSSILKDKEPIKGKEEKVPASLKEKEPETKKDEKMSKAGKEV 507

Query: 702 ERQKAEMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDAR 761
           + +  ++     ++ E   K      I E   + K+    ++K ++ +           +
Sbjct: 508 KPKPPQLQGKKEEKPEPQIKKEAKPAISEKVQIHKQ---DIVKPEKTVSHGKPEEKVLKQ 564

Query: 762 FQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKARQRERKEQELTQAIKKKESEIEKESQR 821
            +A+         P+     + +    I  +K +   +   E+T++ KKK    EKES+ 
Sbjct: 565 VKAVTIEKTAKPKPTKKAEHREREPPSIKTDKPKPTPKGTSEVTESGKKKTEISEKESKE 624

Query: 822 KSIDPALSMLIKSIKTKTEQFQARKKQKVK 851
           K+      +  + + T+ E  Q     K +
Sbjct: 625 KA--DMKHLREEKVSTRKESLQLHNVTKAE 652



 Score = 41.2 bits (95), Expect = 0.004
 Identities = 54/240 (22%), Positives = 100/240 (41%), Gaps = 29/240 (12%)

Query: 86  SKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANHKGSENKTDLD---NSIGIKKMKT 142
           S AL +K+ +KKK +  K++ S    E KK+ K+   K SE +T +D      G      
Sbjct: 306 SPALEEKEGEKKKAE--KKVTS----ETKKKEKEDIKKKSEKETAIDVEKKEPGKASETK 359

Query: 143 SCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSSLEEKQRTLDSGTS----EIVKS 198
               KI +  + KKD K+   K K +K   V+       E+K++ ++   S      V S
Sbjct: 360 QGTVKIAAQAAAKKDEKKEDSK-KTKKPAEVEQPKGKKQEKKEKHVEPAKSPKKEHSVPS 418

Query: 199 PRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKDALEEDSESVSEIGSDEESENE 258
            +   +KT R  + +  + + +   G +     +  +++  +E S   S I  D+E    
Sbjct: 419 DKQVKAKTERAKEEIGAVSIKKAVPGKKEEKTTKTVEQEIRKEKSGKTSSILKDKEPIK- 477

Query: 259 ITSVGRASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDSGPDLARGKGNIETSSEDEDD 318
                       G E  E+     +E E E  +D+  S +G ++      ++   E++ +
Sbjct: 478 ------------GKE--EKVPASLKEKEPETKKDEKMSKAGKEVKPKPPQLQGKKEEKPE 523



 Score = 39.7 bits (91), Expect = 0.012
 Identities = 47/236 (19%), Positives = 92/236 (38%), Gaps = 14/236 (5%)

Query: 91  QKKIKKKKTQTKKEIDSKNLVEKKKETKKANHKGSENKTDLDNSIGIKKMKTSCKFKIDS 150
           ++KI+ K T  +KE   + + EK+K  KKA HK    K +   +  + K +   K    S
Sbjct: 155 ERKIQTKVTHKEKEKGKEKVREKEKPEKKATHKEKIEKKEKPETKTLAKEQKKAKTAEKS 214

Query: 151 NISPKKDSKEFTQKNKKE---KKNIVQHTTDSSLEEKQRTLDSGTSEIVKSPRIECSKTR 207
               KK+ K   Q+  K+   K   VQ T     E++ +   + +    K     C    
Sbjct: 215 EEKTKKEVKGGKQEKVKQTAAKVKEVQKTPSKPKEKEDKEKAAVSKHEQKDQYAFC---- 270

Query: 208 REMQSVVQLIMTRD-SDGYENSTDGEMCDKDALEEDSESVS---EIGSDEESENEITSVG 263
              + ++ + +  D   G   +    +  + A      S +   + G  +++E ++TS  
Sbjct: 271 ---RYMIDIFVHGDLKPGQSPAIPPPLPTEQASRPTPASPALEEKEGEKKKAEKKVTSET 327

Query: 264 RASGDDDGSEDDEEEDEDEEEDEDEDSEDDDKSDSGPDLARGKGNIETSSEDEDDT 319
           +    +D  +  E+E   + E ++     + K  +    A+     +   ED   T
Sbjct: 328 KKKEKEDIKKKSEKETAIDVEKKEPGKASETKQGTVKIAAQAAAKKDEKKEDSKKT 383



 Score = 35.4 bits (80), Expect = 0.23
 Identities = 33/136 (24%), Positives = 60/136 (44%), Gaps = 15/136 (11%)

Query: 73  DLSDSDSNLSGEDSKALSQKKIKKKKTQTKKEIDSKNLVEKKKETKKANHKGSENKTDLD 132
           D  D D++    D   L +K+I K KT+ +++       E+K +T K  HK  E   +  
Sbjct: 122 DDGDEDTDKGEIDEPPLRKKEIHKDKTEKQEK------PERKIQT-KVTHKEKEKGKEKV 174

Query: 133 NSIGIKKMKTSCKFKIDSNISPKKDSKEFTQKNKKEKKNIVQHTTDSSLEEKQRTLDSGT 192
                 + K + K KI+    P  ++K   ++ KK K      T + S E+ ++ +  G 
Sbjct: 175 REKEKPEKKATHKEKIEKKEKP--ETKTLAKEQKKAK------TAEKSEEKTKKEVKGGK 226

Query: 193 SEIVKSPRIECSKTRR 208
            E VK    +  + ++
Sbjct: 227 QEKVKQTAAKVKEVQK 242


>gi|222418637 golgi autoantigen, golgin subfamily a-like [Homo
           sapiens]
          Length = 750

 Score = 58.2 bits (139), Expect = 3e-08
 Identities = 59/307 (19%), Positives = 147/307 (47%), Gaps = 28/307 (9%)

Query: 522 LNRKFKKEELL--DMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKTKKSQKDDEEQI 579
           L RK ++ +LL      QA      ++ + +  +LQ      VEE+    +  +  EE++
Sbjct: 247 LKRKLERAKLLLPQQQLQAEADHLGKELQSVSAKLQAQ----VEENELWNRLNQQQEEKM 302

Query: 580 AKYRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNK---LEGKDKLTPWEQFL 636
            +  + +Q  +EK ++ +E   E E K    ++E  E+M + +    E ++K+   E+ +
Sbjct: 303 WRQEEKIQEWEEKIQEQEEKIREQEEK----IREQEEKMRRQEEMMWEKEEKMRRQEEMM 358

Query: 637 EKKKEKKRLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPE 696
            +K+EK  ++R+++ + E+  +     ++         E+++    ++ ++  ++    E
Sbjct: 359 WEKEEK--MRRQEEMMWEKEEKMRRQEEMMWEKEEKIRELEEKMHEQEKIREQEEKRQEE 416

Query: 697 EEIEIERQKAEMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVN 756
           E+I  + ++ E    M  ++E         KI E +   ++++K++ +++E I +  ++ 
Sbjct: 417 EKIREQEKRQEQEAKMWRQEE---------KIREQEEKIREQEKKMWRQEEKIHEQEKIR 467

Query: 757 VNDAR--FQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKARQRERKEQELTQAIKKKESE 814
             + R   + M+       +  +   +K K  E+  EEK R++E K     + I+++E +
Sbjct: 468 EEEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQ--EEKIRKQEEKVWRQEEKIREQEEK 525

Query: 815 IEKESQR 821
           I ++ ++
Sbjct: 526 IREQEEK 532



 Score = 52.8 bits (125), Expect = 1e-06
 Identities = 62/318 (19%), Positives = 147/318 (46%), Gaps = 38/318 (11%)

Query: 517 ERITMLNRKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGKTKKSQKDDE 576
           E+I     K +++E +  + +  +    E   E EE+++  + +  E++ K ++ ++   
Sbjct: 328 EKIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMWEKEEKMRRQEEMMW 387

Query: 577 EQIAKYRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFL 636
           E+  K R+L + + E+EK  ++ +   E       +E   E  K + E + K+   E+ +
Sbjct: 388 EKEEKIRELEEKMHEQEKIREQEEKRQE-------EEKIREQEKRQ-EQEAKMWRQEEKI 439

Query: 637 EKKKEKKRLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPE 696
            +++EK R + K+    EE   E+             E++++    ++  +  +      
Sbjct: 440 REQEEKIREQEKKMWRQEEKIHEQ-------------EKIREEEKRQEQEEMWRQEEKIH 486

Query: 697 EEIEIERQKAEMALLMMDEDEDSKKH-----FNYNKIVEHQNLSKKKKKQLMKKKELIED 751
           E+ EI RQK +    M +++E  +K          KI E +   +++++++ +++E I +
Sbjct: 487 EQEEIWRQKEK----MHEQEEKIRKQEEKVWRQEEKIREQEEKIREQEEKMWRQEEKIRE 542

Query: 752 DFEVNVNDARF--QAMYTSHLFNLDPSDPNFKKTKAM----EKI--LEEKARQRERKEQE 803
             E+   + +   Q          +  D  +++ + +    EK+   EEK R++E K QE
Sbjct: 543 QEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWRQEEKIREQEEKRQE 602

Query: 804 LTQAIKKKESEIEKESQR 821
             + + K+E +I ++ ++
Sbjct: 603 QEEKMWKQEEKIREQEEK 620



 Score = 52.4 bits (124), Expect = 2e-06
 Identities = 61/349 (17%), Positives = 162/349 (46%), Gaps = 22/349 (6%)

Query: 508 EITWDETDHERITMLNRKFKKEELLDMDFQAYLASSSEDEEEIEEELQGDDGVNVEEDGK 567
           E+ W++ +  R       ++KEE +    +  +    E   E+EE++   + +  +E+ +
Sbjct: 356 EMMWEKEEKMR-RQEEMMWEKEEKMRRQ-EEMMWEKEEKIRELEEKMHEQEKIREQEEKR 413

Query: 568 TK----KSQKDDEEQIAKYRQLLQVIQEKEKKGKENDMEMEIKWVPGLKESAEEMVKNKL 623
            +    + Q+  +EQ AK  +  + I+E+E+K +E + +M   W    K   +E ++ + 
Sbjct: 414 QEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKM---WRQEEKIHEQEKIREEE 470

Query: 624 EGKDKLTPWEQFLEKKKEKKRLKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGINK 683
           + +++   W Q  +  ++++  ++K+K   +E    +    V   +    E+ ++I   +
Sbjct: 471 KRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIREQE 530

Query: 684 KSVKSAKDGTSPEEEIEIERQKAEMALLMMDEDEDSKKHFNYNKIVEHQNLSKKKKKQLM 743
           + +   ++    +EE+  E +K      + +E+   K+    +K+   +   +++++++ 
Sbjct: 531 EKMWRQEEKIREQEEMWREEEKMHEQEKIWEEE---KRQEQEDKMWRQEEKIREQEEKVW 587

Query: 744 KKKELIEDDFEVNVNDARFQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKARQRERKEQE 803
           +++E I +  E               +      +   K  +  EKI E++ + RE  ++E
Sbjct: 588 RQEEKIREQEEKRQEQEEKMWKQEEKI-----REQEEKIQEQEEKIREQEEKIRE--QEE 640

Query: 804 LTQAIKKKESEIEK---ESQRKSIDPALSMLIKSIKTKTEQFQARKKQK 849
           +TQ  ++K  E E+   E + K  +   +M  +  K + ++ + R++++
Sbjct: 641 MTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEE 689



 Score = 52.0 bits (123), Expect = 2e-06
 Identities = 64/339 (18%), Positives = 154/339 (45%), Gaps = 39/339 (11%)

Query: 543 SSEDEEEI---EEELQGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLLQVIQEKEKKGKEN 599
           + + EE++   EE++Q  +    E++ K ++ ++   EQ  K R+  +++ EKE+K +  
Sbjct: 295 NQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEEKIREQEEKMRRQEEMMWEKEEKMRRQ 354

Query: 600 DMEMEIKWVPGLK-ESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKR-------------- 644
           +   E+ W    K    EEM+  K   ++K+   E+ + +K+EK R              
Sbjct: 355 E---EMMWEKEEKMRRQEEMMWEK---EEKMRRQEEMMWEKEEKIRELEEKMHEQEKIRE 408

Query: 645 ---LKRKQKALAEEASEEELPSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIEI 701
               +++++ + E+   +E  + +   +    E+ ++I   +K +   ++    +E+I  
Sbjct: 409 QEEKRQEEEKIREQEKRQEQEAKMWRQEEKIREQEEKIREQEKKMWRQEEKIHEQEKIRE 468

Query: 702 ERQKAEMALLMMDED---EDSKKHFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVN 758
           E ++ E   +   E+   E  +      K+ E +   +K+++++ +++E I +  E    
Sbjct: 469 EEKRQEQEEMWRQEEKIHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQEEKIREQEEKIRE 528

Query: 759 DARFQAMYTSHLFNLDPSDPNFKKTKAMEKILEEKARQ--------RERKEQELTQAIKK 810
                      +   +      +K    EKI EE+ RQ        +E K +E  + + +
Sbjct: 529 QEEKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQEEKVWR 588

Query: 811 KESEI-EKESQRKSIDPALSMLIKSIKTKTEQFQARKKQ 848
           +E +I E+E +R+  +  +    + I+ + E+ Q ++++
Sbjct: 589 QEEKIREQEEKRQEQEEKMWKQEEKIREQEEKIQEQEEK 627



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 95/591 (16%), Positives = 232/591 (39%), Gaps = 70/591 (11%)

Query: 178 DSSLEEKQRTLDSGTSEIVKSPRIECSKTRREMQSVVQLIMTRDSDGYENSTDGEMCDKD 237
           ++ L+EK + ++S  SEI    ++   + +R+++    L+  +              + D
Sbjct: 223 NAKLQEKLQLVESEKSEI----QLNVKELKRKLERAKLLLPQQQLQA----------EAD 268

Query: 238 ALEEDSESVSEIGSDEESENEITSVGRASGDDDGSEDDEEEDEDEE---EDEDEDSEDDD 294
            L ++ +SVS     +  ENE+ +      ++     +E+  E EE   E E++  E ++
Sbjct: 269 HLGKELQSVSAKLQAQVEENELWNRLNQQQEEKMWRQEEKIQEWEEKIQEQEEKIREQEE 328

Query: 295 KSDSGPDLARGKGNIETSSEDEDDTADLFPEESGFEHAWRELDKDAPRADEITRRLAVCN 354
           K     +  R +  +    E++    +    E   E   R  ++     +E  RR     
Sbjct: 329 KIREQEEKMRRQEEMMWEKEEKMRRQEEMMWEK--EEKMRRQEEMMWEKEEKMRRQE--E 384

Query: 355 MDWDRL-KAKDLLALFNSFKPKGGVIFSVKIYPSEFGKERMKEEQVQGPVELLSIPEDAP 413
           M W++  K ++L                 K++  E  +E+ ++ Q +  +      ++  
Sbjct: 385 MMWEKEEKIREL---------------EEKMHEQEKIREQEEKRQEEEKIREQEKRQEQE 429

Query: 414 EKDWTSREKLRDYQFKRLKYYYAVVDCDSPETASKIYEDCDGLEFESSCSFIDLRFIPDD 473
            K W   EK+R+ + K              E   K++   + +  +      + R   ++
Sbjct: 430 AKMWRQEEKIREQEEK------------IREQEKKMWRQEEKIHEQEKIREEEKRQEQEE 477

Query: 474 ITFDDEPKDVASEVNLTAYKPKYFTSAAMGTSTVEITWDETDHERITMLNRKFKKEELLD 533
           +   +E   +  +  +   K K            E  W +   E+I     K +++E   
Sbjct: 478 MWRQEEK--IHEQEEIWRQKEKMHEQEEKIRKQEEKVWRQ--EEKIREQEEKIREQE--- 530

Query: 534 MDFQAYLASSSEDEEEI-EEELQGDDGVNVEEDGKTKKSQKDDEEQIAKYRQLLQVIQEK 592
                        EE+I E+E    +   + E  K  + +K  E++   +RQ  ++ +++
Sbjct: 531 -------EKMWRQEEKIREQEEMWREEEKMHEQEKIWEEEKRQEQEDKMWRQEEKIREQE 583

Query: 593 EKKGKENDMEMEIKWVPGLKESAEEMVKNKLEGKDKLTPWEQFLEKKKEKKRLKRKQKAL 652
           EK  ++ +   E       +E  +E  +   + ++K+   E+ +++++EK R + ++   
Sbjct: 584 EKVWRQEEKIRE------QEEKRQEQEEKMWKQEEKIREQEEKIQEQEEKIREQEEKIRE 637

Query: 653 AEEASEEELPSDVDLNDPYFAEEVKQIGINKKSVKSAKDGTSPEEEIEIERQKAEMALLM 712
            EE ++E+     +  +    +E K     +   +  +     E++I  + +K      M
Sbjct: 638 QEEMTQEQEEKMGEQEEKMCEQEEKMQEQEETMWRQEEKIREQEKKIREQEEKIREQEEM 697

Query: 713 MDEDEDSKKHFNYNKIVEHQNLSKKKKKQLMKKKELIEDDFEVNVNDARFQ 763
           M E E+           + + + ++++K   +++++ E +  +   + + Q
Sbjct: 698 MQEQEEKMWEQEEKMCEQEEKMQEQEEKMRRQEEKMWEQEVRLRQQEEKMQ 748


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.306    0.126    0.340 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 32,718,666
Number of Sequences: 37866
Number of extensions: 1745935
Number of successful extensions: 42150
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 755
Number of HSP's successfully gapped in prelim test: 1119
Number of HSP's that attempted gapping in prelim test: 12129
Number of HSP's gapped (non-prelim): 14165
length of query: 851
length of database: 18,247,518
effective HSP length: 111
effective length of query: 740
effective length of database: 14,044,392
effective search space: 10392850080
effective search space used: 10392850080
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 66 (30.0 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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