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Search of human proteins with 18087853
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|18087853 phosphatase and actin regulator 3 isoform 1 [Homo
sapiens]
(559 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|18087853 phosphatase and actin regulator 3 isoform 1 [Homo sa... 1098 0.0
gi|34304354 phosphatase and actin regulator 3 isoform 2 [Homo sa... 1020 0.0
gi|34304356 phosphatase and actin regulator 3 isoform 3 [Homo sa... 800 0.0
gi|54144631 phosphatase and actin regulator 1 [Homo sapiens] 367 e-101
gi|154354970 phosphatase and actin regulator 2 isoform 2 [Homo s... 293 4e-79
gi|154354972 phosphatase and actin regulator 2 isoform 4 [Homo s... 292 5e-79
gi|154354974 phosphatase and actin regulator 2 isoform 3 [Homo s... 229 5e-60
gi|154354968 phosphatase and actin regulator 2 isoform 1 [Homo s... 229 5e-60
gi|115430209 phosphatase and actin regulator 4 isoform 2 [Homo s... 218 9e-57
gi|115430211 phosphatase and actin regulator 4 isoform 1 [Homo s... 218 9e-57
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 56 8e-08
gi|56549694 enabled homolog isoform a [Homo sapiens] 51 2e-06
gi|39930375 enabled homolog isoform b [Homo sapiens] 51 2e-06
gi|22035604 mitogen-activated protein kinase kinase kinase kinas... 50 4e-06
gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo sa... 49 1e-05
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 49 1e-05
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 49 2e-05
gi|88501738 TRIO and F-actin binding protein isoform 6 [Homo sap... 47 4e-05
gi|148727255 microtubule associated serine/threonine kinase fami... 47 4e-05
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 47 4e-05
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 47 5e-05
gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isof... 47 6e-05
gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens] 46 8e-05
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 46 1e-04
gi|66529407 tensin [Homo sapiens] 46 1e-04
gi|197333879 genetic suppressor element 1 isoform 2 [Homo sapiens] 46 1e-04
gi|44955926 genetic suppressor element 1 isoform 1 [Homo sapiens] 46 1e-04
gi|148746195 trichohyalin [Homo sapiens] 45 1e-04
gi|22035606 mitogen-activated protein kinase kinase kinase kinas... 45 2e-04
gi|22035602 mitogen-activated protein kinase kinase kinase kinas... 45 2e-04
>gi|18087853 phosphatase and actin regulator 3 isoform 1 [Homo
sapiens]
Length = 559
Score = 1098 bits (2841), Expect = 0.0
Identities = 559/559 (100%), Positives = 559/559 (100%)
Query: 1 MAASEDGSGCLVSRGRSQSDPSVLTDSSATSSADAGENPDEMDQTPPARPEYLVSGIRTP 60
MAASEDGSGCLVSRGRSQSDPSVLTDSSATSSADAGENPDEMDQTPPARPEYLVSGIRTP
Sbjct: 1 MAASEDGSGCLVSRGRSQSDPSVLTDSSATSSADAGENPDEMDQTPPARPEYLVSGIRTP 60
Query: 61 PVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAGRQGREELIKKGLLEMMEQD 120
PVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAGRQGREELIKKGLLEMMEQD
Sbjct: 61 PVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAGRQGREELIKKGLLEMMEQD 120
Query: 121 AESKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGSPLATGTDQVSLDKPLSSAAHLDDA 180
AESKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGSPLATGTDQVSLDKPLSSAAHLDDA
Sbjct: 121 AESKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGSPLATGTDQVSLDKPLSSAAHLDDA 180
Query: 181 AKMPSASSGEEADAGSLLPTTNELSQALAGADSLDSPPRPLERSVGQLPSPPLLPTPPPK 240
AKMPSASSGEEADAGSLLPTTNELSQALAGADSLDSPPRPLERSVGQLPSPPLLPTPPPK
Sbjct: 181 AKMPSASSGEEADAGSLLPTTNELSQALAGADSLDSPPRPLERSVGQLPSPPLLPTPPPK 240
Query: 241 ASSKTTKNVTGQATLFQASSMKSADPSLRGQLSTPTGSPHLTTVHRPLPPSRVIEELHRA 300
ASSKTTKNVTGQATLFQASSMKSADPSLRGQLSTPTGSPHLTTVHRPLPPSRVIEELHRA
Sbjct: 241 ASSKTTKNVTGQATLFQASSMKSADPSLRGQLSTPTGSPHLTTVHRPLPPSRVIEELHRA 300
Query: 301 LATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESE 360
LATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESE
Sbjct: 301 LATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESE 360
Query: 361 ENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRN 420
ENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRN
Sbjct: 361 ENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRN 420
Query: 421 IFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLT 480
IFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLT
Sbjct: 421 IFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLT 480
Query: 481 RKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAAIRKELNEYK 540
RKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAAIRKELNEYK
Sbjct: 481 RKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAAIRKELNEYK 540
Query: 541 SNEMEVHASSKHLTRFHRP 559
SNEMEVHASSKHLTRFHRP
Sbjct: 541 SNEMEVHASSKHLTRFHRP 559
>gi|34304354 phosphatase and actin regulator 3 isoform 2 [Homo
sapiens]
Length = 518
Score = 1020 bits (2637), Expect = 0.0
Identities = 518/518 (100%), Positives = 518/518 (100%)
Query: 42 MDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAG 101
MDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAG
Sbjct: 1 MDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAG 60
Query: 102 RQGREELIKKGLLEMMEQDAESKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGSPLATG 161
RQGREELIKKGLLEMMEQDAESKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGSPLATG
Sbjct: 61 RQGREELIKKGLLEMMEQDAESKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGSPLATG 120
Query: 162 TDQVSLDKPLSSAAHLDDAAKMPSASSGEEADAGSLLPTTNELSQALAGADSLDSPPRPL 221
TDQVSLDKPLSSAAHLDDAAKMPSASSGEEADAGSLLPTTNELSQALAGADSLDSPPRPL
Sbjct: 121 TDQVSLDKPLSSAAHLDDAAKMPSASSGEEADAGSLLPTTNELSQALAGADSLDSPPRPL 180
Query: 222 ERSVGQLPSPPLLPTPPPKASSKTTKNVTGQATLFQASSMKSADPSLRGQLSTPTGSPHL 281
ERSVGQLPSPPLLPTPPPKASSKTTKNVTGQATLFQASSMKSADPSLRGQLSTPTGSPHL
Sbjct: 181 ERSVGQLPSPPLLPTPPPKASSKTTKNVTGQATLFQASSMKSADPSLRGQLSTPTGSPHL 240
Query: 282 TTVHRPLPPSRVIEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREE 341
TTVHRPLPPSRVIEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREE
Sbjct: 241 TTVHRPLPPSRVIEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREE 300
Query: 342 AWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKE 401
AWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKE
Sbjct: 301 AWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKE 360
Query: 402 LLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILK 461
LLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILK
Sbjct: 361 LLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILK 420
Query: 462 QRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPW 521
QRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPW
Sbjct: 421 QRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPW 480
Query: 522 TRLSAADKAAIRKELNEYKSNEMEVHASSKHLTRFHRP 559
TRLSAADKAAIRKELNEYKSNEMEVHASSKHLTRFHRP
Sbjct: 481 TRLSAADKAAIRKELNEYKSNEMEVHASSKHLTRFHRP 518
>gi|34304356 phosphatase and actin regulator 3 isoform 3 [Homo
sapiens]
Length = 448
Score = 800 bits (2067), Expect = 0.0
Identities = 431/520 (82%), Positives = 433/520 (83%), Gaps = 74/520 (14%)
Query: 42 MDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAG 101
MDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAG
Sbjct: 1 MDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAG 60
Query: 102 RQGREELIKKGLLEMMEQDAESKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGSPLATG 161
RQGREELIKKGLLEMMEQDAESKTCNPDGGPRSVQSEPPTPKSETLTS
Sbjct: 61 RQGREELIKKGLLEMMEQDAESKTCNPDGGPRSVQSEPPTPKSETLTS------------ 108
Query: 162 TDQVSLDKPLSSAAHLDDAAKMPSASSGEEADAGSLLPTTNELSQALAGAD--SLDSPPR 219
E+A GS L T G D SLD P
Sbjct: 109 ----------------------------EDAQPGSPLAT---------GTDQVSLDKP-- 129
Query: 220 PLERSVGQLPSPPLLPTPPPKASSKTTKNVTGQATLFQASSMKSADPSLRGQLSTPTGSP 279
SS + GQATLFQASSMKSADPSLRGQLSTPTGSP
Sbjct: 130 ---------------------LSSAAHLDDAGQATLFQASSMKSADPSLRGQLSTPTGSP 168
Query: 280 HLTTVHRPLPPSRVIEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKER 339
HLTTVHRPLPPSRVIEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKER
Sbjct: 169 HLTTVHRPLPPSRVIEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKER 228
Query: 340 EEAWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCK 399
EEAWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCK
Sbjct: 229 EEAWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCK 288
Query: 400 KELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNI 459
KELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNI
Sbjct: 289 KELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNI 348
Query: 460 LKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADK 519
LKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADK
Sbjct: 349 LKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADK 408
Query: 520 PWTRLSAADKAAIRKELNEYKSNEMEVHASSKHLTRFHRP 559
PWTRLSAADKAAIRKELNEYKSNEMEVHASSKHLTRFHRP
Sbjct: 409 PWTRLSAADKAAIRKELNEYKSNEMEVHASSKHLTRFHRP 448
>gi|54144631 phosphatase and actin regulator 1 [Homo sapiens]
Length = 580
Score = 367 bits (943), Expect = e-101
Identities = 248/576 (43%), Positives = 331/576 (57%), Gaps = 83/576 (14%)
Query: 12 VSRGRSQSDPSVLTDSSATSSADAGENPDEMDQTPPARPEYLVSGIRTPPVRRNSKLATL 71
+ R RS+SD L ++ + + A E E+++ R + LV G TPP+RR SK A L
Sbjct: 60 IRRVRSKSDTPYLAEARISFNLGAAE---EVERLAAMRSDSLVPGTHTPPIRRRSKFANL 116
Query: 72 GRIFKPWKWRKKKNEKLKQTTSALEKKMAGRQGREELIKKGLL-EMMEQDAESKTCNPDG 130
GRIFKPWKWRKKK+EK K T++ALE+K++ RQ REELIK+G+L E+ ++D E N +
Sbjct: 117 GRIFKPWKWRKKKSEKFKHTSAALERKISMRQSREELIKRGVLKEIYDKDGELSISNEED 176
Query: 131 GPRSVQSEPPTPKSETLTSEDAQPGSPLATGTDQVSLDKPLSSAAHLDDAAKMPSASSGE 190
+ QS + Q+SL P+ S E
Sbjct: 177 SLENGQS----------------------LSSSQLSL----------------PALSEME 198
Query: 191 EADAGSLLPTTNELSQALAGADSLDSPPRPLERSVGQLP---SPPLLPTP---------P 238
+P + L +D +D P + LP SPPL P P
Sbjct: 199 PVP----MPRDPCSYEVLQPSDIMDGPDPGAPVKLPCLPVKLSPPLPPKKVMICMPVGGP 254
Query: 239 PKASSKTTKNVTGQATLFQASSMKSADPS-LRGQLSTPTGSPHL--TTVHRPLPPS--RV 293
+ T +GQ + A + PS ++ QL + HL TT P+ PS R+
Sbjct: 255 DLSLVSYTAQKSGQQGV--AQHHHTVLPSQIQHQLQYGSHGQHLPSTTGSLPMHPSGCRM 312
Query: 294 IEELHRALA-TKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFD-GALEN 351
I+EL++ LA T R +S + R + +S + G +A +
Sbjct: 313 IDELNKTLAMTMQRLESSEQRVPCSTSY--------HSSGLHSGDGVTKAGPMGLPEIRQ 364
Query: 352 KRTAAKESEENKENLIINSELKDDLLLY-------QDEEALNDSIISGTLPRK-CKKELL 403
T E ++NKEN+ S+ +D LY +++E + S+ + +L K C+K+ L
Sbjct: 365 VPTVVIECDDNKENVPHESDYEDSSCLYTREEEEEEEDEDDDSSLYTSSLAMKVCRKDSL 424
Query: 404 AVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQR 463
A+KL NRPSK+ELE++NI PR+TDEER E+RQQI KL++RLSQRP EELE+RNILK R
Sbjct: 425 AIKLSNRPSKRELEEKNILPRQTDEERLELRQQIGTKLTRRLSQRPTAEELEQRNILKPR 484
Query: 464 NDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTR 523
N+Q EQEE+REIK+RLTRKL+QRPTV+ELR+RKILIRFSDYVEVA AQDYDRRADKPWTR
Sbjct: 485 NEQEEQEEKREIKRRLTRKLSQRPTVEELRERKILIRFSDYVEVADAQDYDRRADKPWTR 544
Query: 524 LSAADKAAIRKELNEYKSNEMEVHASSKHLTRFHRP 559
L+AADKAAIRKELNE+KS EMEVH S+HLTRFHRP
Sbjct: 545 LTAADKAAIRKELNEFKSTEMEVHELSRHLTRFHRP 580
>gi|154354970 phosphatase and actin regulator 2 isoform 2 [Homo
sapiens]
Length = 565
Score = 293 bits (749), Expect = 4e-79
Identities = 207/571 (36%), Positives = 301/571 (52%), Gaps = 48/571 (8%)
Query: 27 SSATSSADAGENPDEMDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKK-N 85
S +T S G + D +D+ A + +G +TPP +R KL+T+G+IFKPWKWRKKK +
Sbjct: 5 SVSTLSPQPG-SVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTS 63
Query: 86 EKLKQTTSALEKKMAGRQGREELIKKGLL-EMMEQDAESKTCNPDGGPRSVQSEPPTPKS 144
+K ++T++ LE+K++ RQ REELI++G+L E+ +QD + + + + +
Sbjct: 64 DKFRETSAVLERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTRE 123
Query: 145 ETLTSEDAQPGS------PLATGTDQVSLDKPLSSAAHLDDAAKMPSASSGEE------- 191
E + + GS PL + S A+ PS SS
Sbjct: 124 ENVVKSEEGNGSVSEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKE 183
Query: 192 ---ADAGSL-----------LPTTNELSQALAGADSLDSPPRPLERSVGQLPSPPLLPTP 237
+ AG++ P T+ LS + + D P E V +P
Sbjct: 184 TVSSKAGTVGTTKGKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGA 243
Query: 238 PPKASSKTTKNVTGQATLFQASSMKSADPSLRGQLSTPTGSPH-LTTVHRPLPPSRVI-E 295
+ + K K++ + A S + L Q T + +P L +V LP S +
Sbjct: 244 EEQNTGKF-KSMVPPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPS 302
Query: 296 ELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTA 355
+L A +R + G G R + + T E GK + + E+ +
Sbjct: 303 QLLWAEEPTNRTTLYSGT---GLSVNRENAKCFTTKE-ELGKTVPQLLTPGLMGESSESF 358
Query: 356 AKESEENKENLIINSELKDDLLLY-------QDEEALNDSIISGTLPRKCKKELLAVKLR 408
+ +E N D +LY +DE+ +S ++ + R+ + LA+KL
Sbjct: 359 SASEDEGHREYQANDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRR---DTLAIKLG 415
Query: 409 NRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTE 468
NRPSK+ELED+NI R ++EERQEIRQQI KL +RLSQRP EELE+RNILKQ+N++ E
Sbjct: 416 NRPSKKELEDKNILQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEE 475
Query: 469 QEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAAD 528
QE + E+K+RL+RKL+ RPTV EL+ R+IL RF++YVEV + DYDRRADKPW RL+ AD
Sbjct: 476 QEAKMELKRRLSRKLSLRPTVAELQARRIL-RFNEYVEVTDSPDYDRRADKPWARLTPAD 534
Query: 529 KAAIRKELNEYKSNEMEVHASSKHLTRFHRP 559
KAAIRKELNE+KS EMEVH S+ TRFHRP
Sbjct: 535 KAAIRKELNEFKSTEMEVHEESRQFTRFHRP 565
>gi|154354972 phosphatase and actin regulator 2 isoform 4 [Homo
sapiens]
Length = 554
Score = 292 bits (748), Expect = 5e-79
Identities = 203/558 (36%), Positives = 295/558 (52%), Gaps = 47/558 (8%)
Query: 40 DEMDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKK-NEKLKQTTSALEKK 98
D +D+ A + +G +TPP +R KL+T+G+IFKPWKWRKKK ++K ++T++ LE+K
Sbjct: 6 DGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERK 65
Query: 99 MAGRQGREELIKKGLL-EMMEQDAESKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGS- 156
++ RQ REELI++G+L E+ +QD + + + + + E + + GS
Sbjct: 66 ISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNGSV 125
Query: 157 -----PLATGTDQVSLDKPLSSAAHLDDAAKMPSASSGEE----------ADAGSL---- 197
PL + S A+ PS SS + AG++
Sbjct: 126 SEKTPPLEEQAEDKKAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGTTK 185
Query: 198 -------LPTTNELSQALAGADSLDSPPRPLERSVGQLPSPPLLPTPPPKASSKTTKNVT 250
P T+ LS + + D P E V +P + + K K++
Sbjct: 186 GKRKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKF-KSMV 244
Query: 251 GQATLFQASSMKSADPSLRGQLSTPTGSPH-LTTVHRPLPPSRVI-EELHRALATKHRQD 308
+ A S + L Q T + +P L +V LP S + +L A +R
Sbjct: 245 PPPPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTT 304
Query: 309 SFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENKENLII 368
+ G G R + + T E GK + + E+ + + +E
Sbjct: 305 LYSGT---GLSVNRENAKCFTTKE-ELGKTVPQLLTPGLMGESSESFSASEDEGHREYQA 360
Query: 369 NSELKDDLLLY-------QDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNI 421
N D +LY +DE+ +S ++ + R+ + LA+KL NRPSK+ELED+NI
Sbjct: 361 NDSDSDGPILYTDDEDEDEDEDGSGESALASKIRRR---DTLAIKLGNRPSKKELEDKNI 417
Query: 422 FPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTR 481
R ++EERQEIRQQI KL +RLSQRP EELE+RNILKQ+N++ EQE + E+K+RL+R
Sbjct: 418 LQRTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSR 477
Query: 482 KLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAAIRKELNEYKS 541
KL+ RPTV EL+ R+IL RF++YVEV + DYDRRADKPW RL+ ADKAAIRKELNE+KS
Sbjct: 478 KLSLRPTVAELQARRIL-RFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKS 536
Query: 542 NEMEVHASSKHLTRFHRP 559
EMEVH S+ TRFHRP
Sbjct: 537 TEMEVHEESRQFTRFHRP 554
>gi|154354974 phosphatase and actin regulator 2 isoform 3 [Homo
sapiens]
Length = 634
Score = 229 bits (584), Expect = 5e-60
Identities = 164/436 (37%), Positives = 225/436 (51%), Gaps = 24/436 (5%)
Query: 139 PPTPKSETLTSEDAQPGSPLATGTDQVSLDKPLSSAAHLDDAAKMPSASSGEEADAGS-- 196
PP P S T E A T + S SS + A+K +S
Sbjct: 208 PPKPASRNTTREAAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGTTKGK 267
Query: 197 ----LLPTTNELSQALAGADSLDSPPRPLERSVGQLPSPPLLPTPPPKASSKTTKNVTGQ 252
P T+ LS + + D P E V +P + + K K++
Sbjct: 268 RKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKF-KSMVPP 326
Query: 253 ATLFQASSMKSADPSLRGQLSTPTGSPH-LTTVHRPLPPSRVI-EELHRALATKHRQDSF 310
+ A S + L Q T + +P L +V LP S + +L A +R +
Sbjct: 327 PPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTTLY 386
Query: 311 QGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENKENLIINS 370
G G R + + T E GK + + E+ + + +E N
Sbjct: 387 SGT---GLSVNRENAKCFTTKE-ELGKTVPQLLTPGLMGESSESFSASEDEGHREYQAND 442
Query: 371 ELKDDLLLY-------QDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFP 423
D +LY +DE+ +S ++ + R+ + LA+KL NRPSK+ELED+NI
Sbjct: 443 SDSDGPILYTDDEDEDEDEDGSGESALASKIRRR---DTLAIKLGNRPSKKELEDKNILQ 499
Query: 424 RRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKL 483
R ++EERQEIRQQI KL +RLSQRP EELE+RNILKQ+N++ EQE + E+K+RL+RKL
Sbjct: 500 RTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKL 559
Query: 484 NQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAAIRKELNEYKSNE 543
+ RPTV EL+ R+IL RF++YVEV + DYDRRADKPW RL+ ADKAAIRKELNE+KS E
Sbjct: 560 SLRPTVAELQARRIL-RFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTE 618
Query: 544 MEVHASSKHLTRFHRP 559
MEVH S+ TRFHRP
Sbjct: 619 MEVHEESRQFTRFHRP 634
Score = 99.0 bits (245), Expect = 1e-20
Identities = 76/247 (30%), Positives = 121/247 (48%), Gaps = 10/247 (4%)
Query: 40 DEMDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKK-NEKLKQTTSALEKK 98
D +D+ A + +G +TPP +R KL+T+G+IFKPWKWRKKK ++K ++T++ LE+K
Sbjct: 6 DGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTSDKFRETSAVLERK 65
Query: 99 MAGRQGREELIKKGLL-EMMEQDAE-SKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPG- 155
++ RQ REELI++G+L E+ +QD + + G E T + + SE+
Sbjct: 66 ISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTREENVVKSEEGNGSV 125
Query: 156 SPLATGTDQVSLDKPLSSAAHLDDAAKMPSASSGEEADAGSLLPTTNEL--SQALAGADS 213
S ++ + DK ++ H + A S P + + A AGA
Sbjct: 126 SEKTPPLEEQAEDKKENTENHSETPAAPALPPSAPPKPRPKPKPKKSPVPPKGATAGASH 185
Query: 214 LDSPPRPLERSVGQLPSPPLLPTPPPK-ASSKTTKNVTGQATLFQASSMK-SADPSLRGQ 271
P++++ + P P PPPK AS TT+ G + + + K SA PS
Sbjct: 186 KGDEVPPIKKNT-KAPGKQ-APVPPPKPASRNTTREAAGSSHSKKTTGSKASASPSTSST 243
Query: 272 LSTPTGS 278
S P S
Sbjct: 244 SSRPKAS 250
>gi|154354968 phosphatase and actin regulator 2 isoform 1 [Homo
sapiens]
Length = 645
Score = 229 bits (584), Expect = 5e-60
Identities = 164/436 (37%), Positives = 225/436 (51%), Gaps = 24/436 (5%)
Query: 139 PPTPKSETLTSEDAQPGSPLATGTDQVSLDKPLSSAAHLDDAAKMPSASSGEEADAGS-- 196
PP P S T E A T + S SS + A+K +S
Sbjct: 219 PPKPASRNTTREAAGSSHSKKTTGSKASASPSTSSTSSRPKASKETVSSKAGTVGTTKGK 278
Query: 197 ----LLPTTNELSQALAGADSLDSPPRPLERSVGQLPSPPLLPTPPPKASSKTTKNVTGQ 252
P T+ LS + + D P E V +P + + K K++
Sbjct: 279 RKTDKQPITSHLSSDTTTSGTSDLKGEPAETRVESFKLEQTVPGAEEQNTGKF-KSMVPP 337
Query: 253 ATLFQASSMKSADPSLRGQLSTPTGSPH-LTTVHRPLPPSRVI-EELHRALATKHRQDSF 310
+ A S + L Q T + +P L +V LP S + +L A +R +
Sbjct: 338 PPVAPAPSPLAPPLPLEDQCITASDTPVVLVSVGADLPVSALDPSQLLWAEEPTNRTTLY 397
Query: 311 QGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENKENLIINS 370
G G R + + T E GK + + E+ + + +E N
Sbjct: 398 SGT---GLSVNRENAKCFTTKE-ELGKTVPQLLTPGLMGESSESFSASEDEGHREYQAND 453
Query: 371 ELKDDLLLY-------QDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFP 423
D +LY +DE+ +S ++ + R+ + LA+KL NRPSK+ELED+NI
Sbjct: 454 SDSDGPILYTDDEDEDEDEDGSGESALASKIRRR---DTLAIKLGNRPSKKELEDKNILQ 510
Query: 424 RRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKL 483
R ++EERQEIRQQI KL +RLSQRP EELE+RNILKQ+N++ EQE + E+K+RL+RKL
Sbjct: 511 RTSEEERQEIRQQIGTKLVRRLSQRPTTEELEQRNILKQKNEEEEQEAKMELKRRLSRKL 570
Query: 484 NQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAAIRKELNEYKSNE 543
+ RPTV EL+ R+IL RF++YVEV + DYDRRADKPW RL+ ADKAAIRKELNE+KS E
Sbjct: 571 SLRPTVAELQARRIL-RFNEYVEVTDSPDYDRRADKPWARLTPADKAAIRKELNEFKSTE 629
Query: 544 MEVHASSKHLTRFHRP 559
MEVH S+ TRFHRP
Sbjct: 630 MEVHEESRQFTRFHRP 645
Score = 99.4 bits (246), Expect = 8e-21
Identities = 80/260 (30%), Positives = 127/260 (48%), Gaps = 11/260 (4%)
Query: 27 SSATSSADAGENPDEMDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKK-N 85
S +T S G + D +D+ A + +G +TPP +R KL+T+G+IFKPWKWRKKK +
Sbjct: 5 SVSTLSPQPG-SVDGLDKASIANSDGPTAGSQTPPFKRKGKLSTIGKIFKPWKWRKKKTS 63
Query: 86 EKLKQTTSALEKKMAGRQGREELIKKGLL-EMMEQDAE-SKTCNPDGGPRSVQSEPPTPK 143
+K ++T++ LE+K++ RQ REELI++G+L E+ +QD + + G E T +
Sbjct: 64 DKFRETSAVLERKISTRQSREELIRRGVLKELPDQDGDVTVNFENSNGHMIPIGEESTRE 123
Query: 144 SETLTSEDAQPG-SPLATGTDQVSLDKPLSSAAHLDDAAKMPSASSGEEADAGSLLPTTN 202
+ SE+ S ++ + DK ++ H + A S P +
Sbjct: 124 ENVVKSEEGNGSVSEKTPPLEEQAEDKKENTENHSETPAAPALPPSAPPKPRPKPKPKKS 183
Query: 203 EL--SQALAGADSLDSPPRPLERSVGQLPSPPLLPTPPPK-ASSKTTKNVTGQATLFQAS 259
+ A AGA P++++ + P P PPPK AS TT+ G + + +
Sbjct: 184 PVPPKGATAGASHKGDEVPPIKKNT-KAPGKQ-APVPPPKPASRNTTREAAGSSHSKKTT 241
Query: 260 SMK-SADPSLRGQLSTPTGS 278
K SA PS S P S
Sbjct: 242 GSKASASPSTSSTSSRPKAS 261
>gi|115430209 phosphatase and actin regulator 4 isoform 2 [Homo
sapiens]
Length = 712
Score = 218 bits (556), Expect = 9e-57
Identities = 157/417 (37%), Positives = 218/417 (52%), Gaps = 42/417 (10%)
Query: 170 PLSSAAHLDDAAKMPSASSGEEADAGSLLPTTNELSQALAGADSLDSPPRPLERSVGQLP 229
P +S L+ AA + + + +E + +T + L S SP PL + P
Sbjct: 311 PSTSVPTLESAAAITTKTPSDEREK-----STCSMGSELLPMISPRSPSPPLPTHIP--P 363
Query: 230 SPPLLPTPPPKASSKTTK-----NVTGQATLFQASSMKSADPSLRGQLSTPTGSPHLTT- 283
PP P P K + ++ + Q K P + L G PH+ +
Sbjct: 364 EPPRTPPFPAKTFQVVPEIEFPPSLDLHQEIPQQEDQKKEVP--KRILDQNFGEPHIPSR 421
Query: 284 -------------VHRPLPPSRVIEELHRALATK-HRQDSFQGRESKGSPKKRLDVRLSR 329
+ PLP + ++E HRA + DSF S + L + +
Sbjct: 422 LPPLPLHIRIQQALTSPLPMTPILEGSHRAHSLLFENSDSFSEDSSTLGRTRSLPITIEM 481
Query: 330 TSSVERGKEREEAWSFDGALENKRTAA-------KESEENKENLIINSELKDDLLLYQDE 382
+ +E E+ + E T+ EE KE+ + + Y+DE
Sbjct: 482 LKVPDDEEEEEQTCPSTFSEEMTPTSVIPKLPQCLREEEEKES----DSDSEGPIQYRDE 537
Query: 383 EALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLS 442
E ++S S + +K+ LA+KL +RPS+ EL + N +P ++ EE EIR QI L
Sbjct: 538 EDEDESYQSALANKVKRKDTLAMKLNHRPSEPEL-NLNSWPCKSKEEWNEIRHQIGNTLI 596
Query: 443 KRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFS 502
+RLSQRP EELE+RNIL+ +N+ Q E+REIK+RLTRKL+QRPTV EL RKIL RF+
Sbjct: 597 RRLSQRPTPEELEQRNILQPKNEADRQAEKREIKRRLTRKLSQRPTVAELLARKIL-RFN 655
Query: 503 DYVEVAKAQDYDRRADKPWTRLSAADKAAIRKELNEYKSNEMEVHASSKHLTRFHRP 559
+YVEV AQDYDRRADKPWT+L+ ADKAAIRKELNE+KS+EMEVH SKH TR+HRP
Sbjct: 656 EYVEVTDAQDYDRRADKPWTKLTPADKAAIRKELNEFKSSEMEVHEESKHFTRYHRP 712
Score = 96.7 bits (239), Expect = 5e-20
Identities = 89/310 (28%), Positives = 137/310 (44%), Gaps = 45/310 (14%)
Query: 26 DSSATSSADAGENPDEMDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKK- 84
D S + DA E D+ P + + +G TPP +R SK + G+IFKPWKWRKKK
Sbjct: 5 DVSRPVNPDAVEEADQPTTEPGMVLDSVEAGDTTPPTKRKSKFSGFGKIFKPWKWRKKKS 64
Query: 85 NEKLKQTTSALEKKMAGRQGREELIKKG-LLEMMEQDAE-----------SKTCNPDGGP 132
++K K+T+ LE+K++ R+ REEL+K+G LLE EQ E + P G
Sbjct: 65 SDKFKETSEVLERKISMRKPREELVKRGVLLEDPEQGGEDPGKPSDAMLKNGHTTPIGNA 124
Query: 133 RS-----VQSEPPTPKS-----------ETLTSEDAQPGSPLATGTDQVSL------DKP 170
RS V+ EP S + L S +QP S + + V +P
Sbjct: 125 RSSSPVQVEEEPVRLASLRKAIPEEDLKKRLGSTGSQPNSEAESVPENVPKPPLLPPKRP 184
Query: 171 LSSAAHLDDAAKMPSASSGEEADAGSLLPTTNELSQALAGADSLDSPPRPLERSVGQLPS 230
LSS+ + + SSG A ++ T+ ++ A A + S + + SV P+
Sbjct: 185 LSSSHEASEGQAKDATSSG--GTARFIISTS--ITTAPAATTAATSLAKTVNLSVTPSPA 240
Query: 231 PPLLPTPPPKASSKTTKNVTGQATLFQ------ASSMKSADPSLRGQLSTPTGSPHLTTV 284
P LP P ++ T ++T Q + ++++P + L+
Sbjct: 241 PRTLPAAPASTNTTATPSLTHMVPAKQPPIPPPKPAHRNSNPVIAELSQAINSGTLLSKP 300
Query: 285 HRPLPPSRVI 294
PLPP R I
Sbjct: 301 SPPLPPKRGI 310
>gi|115430211 phosphatase and actin regulator 4 isoform 1 [Homo
sapiens]
Length = 702
Score = 218 bits (556), Expect = 9e-57
Identities = 157/417 (37%), Positives = 218/417 (52%), Gaps = 42/417 (10%)
Query: 170 PLSSAAHLDDAAKMPSASSGEEADAGSLLPTTNELSQALAGADSLDSPPRPLERSVGQLP 229
P +S L+ AA + + + +E + +T + L S SP PL + P
Sbjct: 301 PSTSVPTLESAAAITTKTPSDEREK-----STCSMGSELLPMISPRSPSPPLPTHIP--P 353
Query: 230 SPPLLPTPPPKASSKTTK-----NVTGQATLFQASSMKSADPSLRGQLSTPTGSPHLTT- 283
PP P P K + ++ + Q K P + L G PH+ +
Sbjct: 354 EPPRTPPFPAKTFQVVPEIEFPPSLDLHQEIPQQEDQKKEVP--KRILDQNFGEPHIPSR 411
Query: 284 -------------VHRPLPPSRVIEELHRALATK-HRQDSFQGRESKGSPKKRLDVRLSR 329
+ PLP + ++E HRA + DSF S + L + +
Sbjct: 412 LPPLPLHIRIQQALTSPLPMTPILEGSHRAHSLLFENSDSFSEDSSTLGRTRSLPITIEM 471
Query: 330 TSSVERGKEREEAWSFDGALENKRTAA-------KESEENKENLIINSELKDDLLLYQDE 382
+ +E E+ + E T+ EE KE+ + + Y+DE
Sbjct: 472 LKVPDDEEEEEQTCPSTFSEEMTPTSVIPKLPQCLREEEEKES----DSDSEGPIQYRDE 527
Query: 383 EALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLS 442
E ++S S + +K+ LA+KL +RPS+ EL + N +P ++ EE EIR QI L
Sbjct: 528 EDEDESYQSALANKVKRKDTLAMKLNHRPSEPEL-NLNSWPCKSKEEWNEIRHQIGNTLI 586
Query: 443 KRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFS 502
+RLSQRP EELE+RNIL+ +N+ Q E+REIK+RLTRKL+QRPTV EL RKIL RF+
Sbjct: 587 RRLSQRPTPEELEQRNILQPKNEADRQAEKREIKRRLTRKLSQRPTVAELLARKIL-RFN 645
Query: 503 DYVEVAKAQDYDRRADKPWTRLSAADKAAIRKELNEYKSNEMEVHASSKHLTRFHRP 559
+YVEV AQDYDRRADKPWT+L+ ADKAAIRKELNE+KS+EMEVH SKH TR+HRP
Sbjct: 646 EYVEVTDAQDYDRRADKPWTKLTPADKAAIRKELNEFKSSEMEVHEESKHFTRYHRP 702
Score = 93.6 bits (231), Expect = 4e-19
Identities = 86/303 (28%), Positives = 133/303 (43%), Gaps = 49/303 (16%)
Query: 37 ENPDEMDQTPPARPEYLVSGIR----TPPVRRNSKLATLGRIFKPWKWRKKK-NEKLKQT 91
E+P E P P ++ + TPP +R SK + G+IFKPWKWRKKK ++K K+T
Sbjct: 2 EDPFEEADQPTTEPGMVLDSVEAGDTTPPTKRKSKFSGFGKIFKPWKWRKKKSSDKFKET 61
Query: 92 TSALEKKMAGRQGREELIKKG-LLEMMEQDAE-----------SKTCNPDGGPRS----- 134
+ LE+K++ R+ REEL+K+G LLE EQ E + P G RS
Sbjct: 62 SEVLERKISMRKPREELVKRGVLLEDPEQGGEDPGKPSDAMLKNGHTTPIGNARSSSPVQ 121
Query: 135 VQSEPPTPKS-----------ETLTSEDAQPGSPLATGTDQVSL------DKPLSSAAHL 177
V+ EP S + L S +QP S + + V +PLSS+
Sbjct: 122 VEEEPVRLASLRKAIPEEDLKKRLGSTGSQPNSEAESVPENVPKPPLLPPKRPLSSSHEA 181
Query: 178 DDAAKMPSASSGEEADAGSLLPTTNELSQALAGADSLDSPPRPLERSVGQLPSPPLLPTP 237
+ + SSG A ++ T+ ++ A A + S + + SV P+P LP
Sbjct: 182 SEGQAKDATSSG--GTARFIISTS--ITTAPAATTAATSLAKTVNLSVTPSPAPRTLPAA 237
Query: 238 PPKASSKTTKNVTGQATLFQ------ASSMKSADPSLRGQLSTPTGSPHLTTVHRPLPPS 291
P ++ T ++T Q + ++++P + L+ PLPP
Sbjct: 238 PASTNTTATPSLTHMVPAKQPPIPPPKPAHRNSNPVIAELSQAINSGTLLSKPSPPLPPK 297
Query: 292 RVI 294
R I
Sbjct: 298 RGI 300
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 56.2 bits (134), Expect = 8e-08
Identities = 108/520 (20%), Positives = 196/520 (37%), Gaps = 72/520 (13%)
Query: 83 KKNEKLKQTTSALEKKMAGRQGREELIKKGLLEMMEQDAESKTCNPDGGPRSVQSEPPTP 142
++ + ++ T EK+ +G+EE + G E E E P S + E +P
Sbjct: 462 EETQVTEEVTEEEEKEAKEEEGKEE--EGGEEEEAEGGEEETKSPPAEEAASPEKEAKSP 519
Query: 143 KSETLTS--EDAQPGSPLATGTDQVSLDKPLSSAAHLDDAAKMPSASSGEEADAGSLLPT 200
E S E P A +V + S A ++A P A S E+ +A S
Sbjct: 520 VKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAK-EEAKSPPEAKSPEKEEAKSPAEV 578
Query: 201 TN---------ELSQALAGADSLDSPPRPLE---RSVGQLPSP-------PLLPTPPPKA 241
+ E +++ A A S + P++ +S + SP P P KA
Sbjct: 579 KSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKA 638
Query: 242 SSKTTKNVTGQATLF-----QASSMKSADPSLRGQLSTPTGSPHLTTVHRPLP------- 289
S T + +A S + A ++ + +P + P
Sbjct: 639 KSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPV 698
Query: 290 ------PSRVIEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAW 343
P + + + + S E+K K + V+ S E+ K E+A
Sbjct: 699 KEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVK-EEAKSPEKAKSPEKAK 757
Query: 344 SFDGALENKRTAAKE-----------------SEENKENLIINSELKDDLLLYQDEEALN 386
+ D +T AKE EE K S LK+D + E
Sbjct: 758 TLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKK 817
Query: 387 DSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLS 446
+ + S P K +++ VK++ P K E E P+ EE+++ +++ + K+ +
Sbjct: 818 EEVKS---PVKEEEKPQEVKVKEPPKKAEEEKAPATPK--TEEKKDSKKE---EAPKKEA 869
Query: 447 QRPAVEELERRNILKQRNDQTE-QEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYV 505
+P VEE + + K + + E ++E E K+++ + P E+++ + +
Sbjct: 870 PKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKED---AKPKEKT 926
Query: 506 EVAKAQDYDRRADKPWTRLSAADKAAIRKELNEYKSNEME 545
EVAK + D +A +P + A +K+ E K+ + E
Sbjct: 927 EVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPE 966
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 51.2 bits (121), Expect = 2e-06
Identities = 46/172 (26%), Positives = 79/172 (45%), Gaps = 19/172 (11%)
Query: 383 EALNDSIISGTLPRKCKKELLAVKLRNRPSKQELE-----------DRNIFPRRTDEERQ 431
E LN TLPR+ + L +++N PS++ELE + + R + ER
Sbjct: 109 EVLNSQETGPTLPRQNSQ--LPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERM 166
Query: 432 EIRQQIEMKLSKRLSQRPAVEE--LERRNILKQRNDQTEQEERREIKQRLTRKLNQRPTV 489
E + +L + +R +E+ LER ++R ++ E++ER E ++RL R+
Sbjct: 167 ERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRER 226
Query: 490 DELRDRKILIRFSDYVEVAKAQDYDRRADKPWTR----LSAADKAAIRKELN 537
E ++R+ L R + + Q+ R W R SAA A++ LN
Sbjct: 227 QERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLN 278
Score = 32.7 bits (73), Expect = 0.90
Identities = 66/329 (20%), Positives = 118/329 (35%), Gaps = 53/329 (16%)
Query: 81 RKKKNEKLKQTTSALEKKMAGRQGREELIKKGLLEMMEQDAESKTCNPDGGPRSVQSEPP 140
R+++ + ++ LE++ R+ +E+L + E +E + E + + P SV+
Sbjct: 224 RERQERQERERLERLERERQERERQEQLER----EQLEWERERRISSA-AAPASVE---- 274
Query: 141 TPKSETLTSEDA-QPG-----SPLATGTDQVSLDKPLSSAAHLDDAAKMPSASSGEEADA 194
TP + L A +PG P T + Q + PL A P A A
Sbjct: 275 TPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPL--------APPPPPPLPPGPAQA 326
Query: 195 GSLLPTTNELSQALAGADSLDSPPRPLERSVGQLPSPPLLPTPPP--------KASSKTT 246
LP + PP P Q+P PP P PP + S+
Sbjct: 327 SVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFLASMSEDN 386
Query: 247 KNVTGQATLFQASSMKSAD-------PSLRGQLSTPTGSPHLTTVH----RPLPPSRVIE 295
+ +TG A + ++ PS + + S T PL S ++E
Sbjct: 387 RPLTGLAAAIAGAKLRKVSRMEDTSFPSGGNAIGVNSASSKTDTGRGNGPLPLGGSGLME 446
Query: 296 EL------HRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGAL 349
E+ R +A K + +E KG + + + S TS+ E + W +
Sbjct: 447 EMSALLARRRRIAEKGSTIETEQKEDKGEDSEPVTSKASSTSTPE---PTRKPWERTNTM 503
Query: 350 ENKRT--AAKESEENKENLIINSELKDDL 376
++ ++ K ++ ++ D L
Sbjct: 504 NGSKSPVISRRDSPRKNQIVFDNRSYDSL 532
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 51.2 bits (121), Expect = 2e-06
Identities = 46/172 (26%), Positives = 79/172 (45%), Gaps = 19/172 (11%)
Query: 383 EALNDSIISGTLPRKCKKELLAVKLRNRPSKQELE-----------DRNIFPRRTDEERQ 431
E LN TLPR+ + L +++N PS++ELE + + R + ER
Sbjct: 109 EVLNSQETGPTLPRQNSQ--LPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERM 166
Query: 432 EIRQQIEMKLSKRLSQRPAVEE--LERRNILKQRNDQTEQEERREIKQRLTRKLNQRPTV 489
E + +L + +R +E+ LER ++R ++ E++ER E ++RL R+
Sbjct: 167 ERERLERERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRER 226
Query: 490 DELRDRKILIRFSDYVEVAKAQDYDRRADKPWTR----LSAADKAAIRKELN 537
E ++R+ L R + + Q+ R W R SAA A++ LN
Sbjct: 227 QERQERERLERLERERQERERQEQLEREQLEWERERRISSAAAPASVETPLN 278
Score = 32.0 bits (71), Expect = 1.5
Identities = 62/285 (21%), Positives = 104/285 (36%), Gaps = 48/285 (16%)
Query: 81 RKKKNEKLKQTTSALEKKMAGRQGREELIKKGLLEMMEQDAESKTCNPDGGPRSVQSEPP 140
R+++ + ++ LE++ R+ +E+L + E +E + E + + P SV+
Sbjct: 224 RERQERQERERLERLERERQERERQEQLER----EQLEWERERRISSA-AAPASVE---- 274
Query: 141 TPKSETLTSEDA-QPG-----SPLATGTDQVSLDKPLSSAAHLDDAAKMPSASSGEEADA 194
TP + L A +PG P T + Q + PL A P A A
Sbjct: 275 TPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPL--------APPPPPPLPPGPAQA 326
Query: 195 GSLLPTTNELSQALAGADSLDSPPRPLERSVGQLPSPPLLPTPPP--------KASSKTT 246
LP + PP P Q+P PP P PP + S+
Sbjct: 327 SVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPASGFFLASMSEDN 386
Query: 247 KNVTGQATLFQASSMKSAD-------PSLRGQLSTPTGSPHLTTVH----RPLPPSRVIE 295
+ +TG A + ++ PS + + S T PL S ++E
Sbjct: 387 RPLTGLAAAIAGAKLRKVSRMEDTSFPSGGNAIGVNSASSKTDTGRGNGPLPLGGSGLME 446
Query: 296 EL------HRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVE 334
E+ R +A K + +E KG + + + S TS+ E
Sbjct: 447 EMSALLARRRRIAEKGSTIETEQKEDKGEDSEPVTSKASSTSTPE 491
>gi|22035604 mitogen-activated protein kinase kinase kinase kinase 4
isoform 2 [Homo sapiens]
Length = 1320
Score = 50.4 bits (119), Expect = 4e-06
Identities = 47/229 (20%), Positives = 103/229 (44%), Gaps = 14/229 (6%)
Query: 334 ERGKEREEAWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGT 393
++ ER+ ++ R E +E + + E ++++ ++E SI++
Sbjct: 291 DQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEV---PEQEGEPSSIVNVP 347
Query: 394 LPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQ----RP 449
+++ L ++ N+ + L + + + E++E ++Q+ + KR+ Q R
Sbjct: 348 GESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRR 407
Query: 450 AVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAK 509
+EE +RR +R + EQ R + ++R +L +R +E R R + V +
Sbjct: 408 RLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRR----AEEEKRRVER 463
Query: 510 AQDYDRR-ADKPWTRLSAADKAAIRKE--LNEYKSNEMEVHASSKHLTR 555
Q+Y RR ++ L + ++++ L E + EME H ++ L R
Sbjct: 464 EQEYIRRQLEEEQRHLEVLQQQLLQEQAMLLECRWREMEEHRQAERLQR 512
>gi|148596949 nucleolar and coiled-body phosphoprotein 1 [Homo
sapiens]
Length = 699
Score = 48.9 bits (115), Expect = 1e-05
Identities = 78/482 (16%), Positives = 174/482 (36%), Gaps = 43/482 (8%)
Query: 27 SSATSSADAGENPDEMDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKKNE 86
+S++ S D+ E +E+ P + + PP + +K + + ++++
Sbjct: 82 ASSSDSEDSSEEEEEVQGPPAKKAAVPAKRVGLPPGKAAAKASESSSSEESSDDDDEEDQ 141
Query: 87 KLKQTTSALEKKMAGRQGREELIKKGLLEMMEQDAESKTCNPDGGPRSVQSE--PPTPKS 144
K + ++ + + + K D++S + + D P++ + + P T K+
Sbjct: 142 KKQPVQKGVKPQAKAAKAPPKKAKSS-------DSDSDSSSEDEPPKNQKPKITPVTVKA 194
Query: 145 ETLTSEDAQPGSPLATGTDQVSLDKPLSSAAHLDDAAKMPSASSGEEADA---------- 194
+T +P S SS++ DD+ + +A++ ++
Sbjct: 195 QTKAPPKPARAAPKIANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPV 254
Query: 195 -GSLLPTTNELSQALAGADSLDSPPRPLERSVGQLPSPPLLPTPPPKASSKT---TKNVT 250
+ PT S + +D + +P++ G S P PPPK S T K V
Sbjct: 255 KAATTPTRKSSSSEDSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVE 314
Query: 251 GQATLFQA-SSMKSADPSLRGQLSTPTGSPHLTTVHRPLPPSRVIEELHRALATKHRQDS 309
Q + + S +D S + PT + +P P + E + + +D
Sbjct: 315 KQQPVESSEDSSDESDSSSEEEKKPPTKAVVSKATTKPPPAKKAAESSSDSSDSDSSEDD 374
Query: 310 FQGRESKGSPKKRLDVRLSRTSS--VERGKEREEAWSFDGALENKRTAAKESEENKENLI 367
+ G+ K + T S V+ ++ L ++ + SEE +
Sbjct: 375 EAPSKPAGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSS-- 432
Query: 368 INSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTD 427
EE +++ T P+ K L++ + P + ++
Sbjct: 433 -------------SEEEKTKKMVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSSSE 479
Query: 428 EERQEIRQQIEMKLSKRLS--QRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQ 485
EE ++ + K ++++ P+ ++ + N + + E +++L K +
Sbjct: 480 EEEEKTSKSAVKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSP 539
Query: 486 RP 487
RP
Sbjct: 540 RP 541
Score = 40.0 bits (92), Expect = 0.006
Identities = 85/440 (19%), Positives = 161/440 (36%), Gaps = 48/440 (10%)
Query: 12 VSRGRSQSDPSVLTDSSATSSADAGENPDEMDQTPPARPEYLVSGIR--TPPVRRNSKLA 69
++ G++ S S + SS++ ++ + +T P + + ++ T P R++S
Sbjct: 209 IANGKAASSSSSSSSSSSSDDSEEEKAAATPKKTVPKKQVVAKAPVKAATTPTRKSSSSE 268
Query: 70 TLG-----RIFKPWKWRKKKNEKLKQTTSALEKKMAGRQGREELIKKGLLEMMEQDAESK 124
KP K + + ++ KK G Q ++ ++K +Q ES
Sbjct: 269 DSSSDEEEEQKKPMKNKPGPYSSVPPPSAPPPKKSLGTQPPKKAVEK------QQPVESS 322
Query: 125 TCNPDGGPRSVQSEPPTPKSETLTSEDAQPGSPLATGTDQVSLDKPLSSAAHLDDAAKMP 184
+ D S + E P ++ +P P A + S D S ++ D+A P
Sbjct: 323 EDSSDESDSSSEEEKKPPTKAVVSKATTKP--PPAKKAAESSSDSSDSDSSEDDEAPSKP 380
Query: 185 SASSGEEADAGSLLPTTNELSQALAGADSLDSPPRPLERSVGQLPSPPLLPTPPPKASSK 244
+ ++ ++ ++ + + A A + + L R S + + + K
Sbjct: 381 AGTTKNSSNKPAVTTKSPAVKPAAAPKQPVGGGQKLLTRKADSSSSEEESSSSEEEKTKK 440
Query: 245 TTKNVTGQATLFQASSM--KSADPSLRGQLSTPTGSPHLTTVHRPLPPSRVIEELHRALA 302
+AT A S+ K A R S S S EE A
Sbjct: 441 MVATTKPKATAKAALSLPAKQAPQGSRDSSSDSDSSS-----------SEEEEEKTSKSA 489
Query: 303 TKHRQDSFQGRESKGSP---KKRLDVRLSRTSSVERGKEREEAWSFDG-----ALENKRT 354
K + G + P KK + +SS + +E EE G A + T
Sbjct: 490 VKKKPQKVAGGAAPSKPASAKKGKAESSNSSSSDDSSEEEEEKLKGKGSPRPQAPKANGT 549
Query: 355 AAKESEENKENLIINSELKDDLLLYQDEEALNDSII---SGTLPRKCKKELLAVKLRNRP 411
+A ++ K NSE ++EE +++ SG+L ++ + E +
Sbjct: 550 SALTAQNGKAAK--NSE-------EEEEEKKKAAVVVSKSGSLKKRKQNEAAKEAETPQA 600
Query: 412 SKQELEDRNIFPRRTDEERQ 431
K +L+ N FP+R E++
Sbjct: 601 KKIKLQTPNTFPKRKKGEKR 620
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 48.9 bits (115), Expect = 1e-05
Identities = 99/458 (21%), Positives = 163/458 (35%), Gaps = 95/458 (20%)
Query: 22 SVLTDSSATSS----ADAGENPDEMDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKP 77
S LT S T S A AGE + P PVRR + + + + K
Sbjct: 368 SPLTPCSVTRSVHRCAPAGERGERRKPNAGGSPA---------PVRRRPEASPVQK--KE 416
Query: 78 WKWRKKKNEKLKQTTSALEKKMAGRQGREELIKKGLLEMMEQDAESKTCNPDGGPRSVQS 137
K ++++NEK K A E+ + RQ + L + K+ P +
Sbjct: 417 KKDKERENEKEKSAL-ARERSLKKRQSLPASPRARLSASTASELSPKSKARPSSPSTSWH 475
Query: 138 EPPTPKSETLTSEDAQPGSPLATGTDQVSLDKPLSSAAHLDDAAKMPSASSGEEADAGSL 197
P +P P P GT P ++A + PSA+ G E + S
Sbjct: 476 RPASPCPSPGPGHTLPPKPPSPRGTTA----SPKGRVRRKEEAKESPSAA-GPEDKSQSK 530
Query: 198 LPTTNELSQALAGADSLDSPPRPLERSVGQLPSPPLLPTP-PPKASSKTTKNVTGQATLF 256
+NE A +P P PSP PTP PP+ + T A L
Sbjct: 531 RRASNEKESA--------APASPA-------PSPAPSPTPAPPQKEQPPAETPTDAAVL- 574
Query: 257 QASSMKSADPSLRGQLSTPTGSPHLTTVHRPLPPSRVIEELHRALATKHRQDSFQGRESK 316
S P +P +T +P+ + EE R LA K RQ RE +
Sbjct: 575 ---------------TSPPAPAPPVTP-SKPMAGTTDREEATRLLAEKRRQ----AREQR 614
Query: 317 GSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENKENLIINSELKDDL 376
++ ++ R +R +E + A + E + A + E+ + + +
Sbjct: 615 EREEQERRLQAERD---KRMREEQLAREAEARAEREAEARRREEQEAREKAQAEQEEQER 671
Query: 377 LLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQ 436
L Q EEA + R +Q LE F ++ ++ERQE R++
Sbjct: 672 LQKQKEEA-------------------EARSREEAERQRLEREKHFQQQ-EQERQERRKR 711
Query: 437 IEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERRE 474
+E E+ +R + ++ ++++ +E
Sbjct: 712 LE--------------EIMKRTRKSEVSETKQKQDSKE 735
Score = 36.2 bits (82), Expect = 0.082
Identities = 60/243 (24%), Positives = 97/243 (39%), Gaps = 33/243 (13%)
Query: 127 NPDGGPRSVQSEPPTPKSETL--TSEDAQPGSPLATGTDQVSLDKPLSSAAHLDDAAKMP 184
+P+G P S PP P S + T D P AT + Q+ L+ P S + + P
Sbjct: 28 SPEGDP----SPPPPPMSALVPDTPPDTPPAMKNATSSKQLPLE-PESPSGQVGPRPAPP 82
Query: 185 SASSGEEADAGSLLPTTNELSQALAGADSLDSPPRPLERSVGQLPSPPLLP---TPPPKA 241
S ++A S PT A+ D+ RP RS PSP +P +PP K
Sbjct: 83 QEES-PSSEAKSRGPTP----PAMGPRDA-----RPPRRS--SQPSPTAVPASDSPPTKQ 130
Query: 242 SSKTT--KNVTGQATLFQASSMKSADPSL---RGQLSTPTGSPHLTTVHRPLPPSRVIEE 296
K ++ + + + +A ++ + + + L R L R+ E
Sbjct: 131 EVKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAE 190
Query: 297 LHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAA 356
RA A + RQ R+ K+R + + R+ + R++ WS+ GAL +
Sbjct: 191 QRRA-ALEERQ-----RQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHSSPGH 244
Query: 357 KES 359
K S
Sbjct: 245 KTS 247
Score = 30.0 bits (66), Expect = 5.8
Identities = 31/116 (26%), Positives = 54/116 (46%), Gaps = 18/116 (15%)
Query: 411 PSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAV--EELERRNILKQRNDQTE 468
P+KQE++ ER ++ ++ + +K L+ + AV E+ E+ L+++ Q +
Sbjct: 127 PTKQEVKKAG--------ERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREK--QLQ 176
Query: 469 QEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRL 524
+ RR +QRL K QR E R R+ L + + E A R K W +
Sbjct: 177 ERRRRLEEQRL--KAEQRRAALEERQRQKLEKNKERYEAA----IQRSVKKTWAEI 226
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 48.5 bits (114), Expect = 2e-05
Identities = 96/448 (21%), Positives = 168/448 (37%), Gaps = 73/448 (16%)
Query: 132 PRSVQSEPPTPKSETLTSEDAQPGSPLATGTDQVSLDKPLSSAAHLDDAAKMPSASSGEE 191
P+ V SE P E A+P P G + S + A+ K P+ASS E
Sbjct: 368 PQKVGSEQKEPPEEAEPVAAAEPEVPENNGNN--SWPHNDTEIANSTPNPK-PAASSPET 424
Query: 192 ADAGSLLPTTNELSQALAGADSLDSPP------RPLERSVGQLPS----------PPLLP 235
AG T++ AD PP R +++V +L PP
Sbjct: 425 PSAGQQEAKTDQ-------ADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSK 477
Query: 236 TPP-PKASSKTTKNVTGQATLFQASSMKSADPSLRGQLSTPTGSPHLTTV-----HRPLP 289
TP P +SK + + Q + M L TPT +P + PL
Sbjct: 478 TPSSPCPASKVVRPLRTFLHTVQRNQM----------LMTPTSAPRSVMKSFIKRNTPLR 527
Query: 290 PSRVIEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGAL 349
+E R + ++++ Q R K KR + + ER ++ L
Sbjct: 528 MDPKEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRK---------VL 578
Query: 350 ENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRN 409
+ + + EE K+ + D+ EE L + K KK+ A K+
Sbjct: 579 QARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEE--------KAKKKAAAKKMEE 630
Query: 410 RPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQ 469
++++ E+ R +E +E R Q ++ K Q + E + + +QR + +
Sbjct: 631 VEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQERRE 690
Query: 470 EERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDR-RADKPWTRLSAA- 527
+ERRE ++R + Q E R+++ E + ++ +R +A++ A
Sbjct: 691 QERREQERREQERREQ-----ERREQE-----RQLAEQERRREQERLQAERELQEREKAL 740
Query: 528 --DKAAIRKELNEYKSNEMEVHASSKHL 553
K +++EL E K E + + + L
Sbjct: 741 RLQKEQLQRELEEKKKKEEQQRLAERQL 768
>gi|88501738 TRIO and F-actin binding protein isoform 6 [Homo
sapiens]
Length = 2365
Score = 47.4 bits (111), Expect = 4e-05
Identities = 81/385 (21%), Positives = 143/385 (37%), Gaps = 41/385 (10%)
Query: 119 QDAESKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGSPLATGT---DQVSLDKPLSSAA 175
+D +C PR+ S P + T+ AQ +P A+ T ++ + D P +S A
Sbjct: 523 RDNPRTSCAQRDNPRA--SSPNRAARDNPTTSCAQRDNPRASRTSSPNRATRDNPRTSCA 580
Query: 176 HLDDAAKMPSASSGEEADAGSLLPTTNELSQALAGADSLDSPPRPLERSVGQLPSPPLLP 235
D+ P ASS A + PTT+ + A SP R+ P
Sbjct: 581 QRDN----PRASSPNRATRDN--PTTSCAQRDNPRASRTSSP----NRATRDNPRTSCAQ 630
Query: 236 TPPPKASS--KTTKNVTGQATLFQASSMKSADPSLRGQLSTPTGSPHLTTVHRPLPPSRV 293
P+ASS +TT+ + + + + +++ P+ Q P S L R PSR
Sbjct: 631 RDNPRASSPNRTTQQDSPRTSCARRDDPRASSPNRTIQQENPRTSCALRDNPRASSPSRT 690
Query: 294 IEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKR 353
I++ + + R D SP + RTS R R + + +N R
Sbjct: 691 IQQENPRTSCAQRDD-----PRASSPNRTTQQENPRTSCARRDNPRASSRNRTIQRDNPR 745
Query: 354 TAAKESEE----------NKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELL 403
T+ + + +ENL + +D+ A D+ + R +
Sbjct: 746 TSCAQRDNPRASSPNRTIQQENLRTSCTRQDNPRTSSPNRATRDNPRTSCAQRDNLRASS 805
Query: 404 AVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQR 463
++ + + + +NI PR + ++ + +KR + RP + +R +
Sbjct: 806 PIRATQQDNPRTCIQQNI-PRSSSTQQDNPK----TSCTKRDNLRPTCTQRDRTQSFSFQ 860
Query: 464 NDQTEQEERREIKQRLTRKLNQRPT 488
D Q T+K N RP+
Sbjct: 861 RDNPGTSS----SQCCTQKENLRPS 881
>gi|148727255 microtubule associated serine/threonine kinase family
member 4 isoform a [Homo sapiens]
Length = 2434
Score = 47.4 bits (111), Expect = 4e-05
Identities = 83/309 (26%), Positives = 126/309 (40%), Gaps = 58/309 (18%)
Query: 55 SGIRTPPVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAGRQGREELIKKGLL 114
+ I+T P RRNS + + R K + KK E L++ S L KK+A +Q L
Sbjct: 1042 TSIKTGPARRNSYKSRMVRRSK----KSKKKESLERRRS-LFKKLA-KQPSPLLHTSRSF 1095
Query: 115 EMMEQDAESKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGSPLATGTDQVSLDKPLSSA 174
+ + S P S+ PTP S + P P T + Q S P SSA
Sbjct: 1096 SCLNRSLSSGESLPGSPTHSLSPRSPTP------SYRSTPDFPSGTNSSQSS--SPSSSA 1147
Query: 175 AHLDDAAKMPSASSGEEADAGSLLPTT-NELSQALAGA--------DSLDSPPRPLERSV 225
P++ +G +G + P+T + L+ L G + + P PL R+
Sbjct: 1148 ---------PNSPAG----SGHIRPSTLHGLAPKLGGQRYRSGRRKSAGNIPLSPLART- 1193
Query: 226 GQLPSPPLLPTPPPKASSKTTKNVTGQATLFQASSMKSADPS------LRGQLSTPTGSP 279
PSP PT P ++ S + G + + QA K P +R + + P SP
Sbjct: 1194 ---PSPTPQPTSPQRSPSPLLGHSLGNSKIAQAFPSKMHSPPTIVRHIVRPKSAEPPRSP 1250
Query: 280 HLTTV--HRPLPPSRVIEELH---RALATKHRQDSFQGRES-KGSPKKRLDVR------L 327
L V L PS ++ H R + + Q+ Q +S + +P + LD L
Sbjct: 1251 LLKRVQSEEKLSPSYGSDKKHLCSRKHSLEVTQEEVQREQSQREAPLQSLDENVCDVPPL 1310
Query: 328 SRTSSVERG 336
SR VE+G
Sbjct: 1311 SRARPVEQG 1319
Score = 30.0 bits (66), Expect = 5.8
Identities = 50/224 (22%), Positives = 85/224 (37%), Gaps = 37/224 (16%)
Query: 124 KTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGSPLATGTDQVSLDKPLSSAAHLDDAAKM 183
KT + DG ++ PP + +L S G P +V A L +
Sbjct: 1852 KTNHKDGPG---EARPPPRDNSSLHSA----GIPCEKELGKVRRGVEPKPEALLARRSLQ 1904
Query: 184 PSASSGEEADAGSLLPTTNELSQALAGADSLDSPPRPLERSVGQLPSPPL----LPTPPP 239
P E+++ S P+ + GA + +PL+R +P PPL L +P
Sbjct: 1905 PPGIESEKSEKLSSFPSLQK-----DGAKEPERKEQPLQRHPSSIPPPPLTAKDLSSPAA 1959
Query: 240 KASSKTTKNVTGQATLFQASSMKSADPSLRGQ-LSTPTGSPHLTTVHRPLP--------- 289
+ + + +G+ + +A+PS Q P + ++ H+P P
Sbjct: 1960 RQHCSSPSHASGRE---PGAKPSTAEPSSSPQDPPKPVAAHSESSSHKPRPGPDPGPPKT 2016
Query: 290 --PSRVIEELHRAL-ATKHRQDSFQ-----GRESKGSPKKRLDV 325
P R + ++ ATK ++ + Q RE KG K DV
Sbjct: 2017 KHPDRSLSSQKPSVGATKGKEPATQSLGGSSREGKGHSKSGPDV 2060
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 47.4 bits (111), Expect = 4e-05
Identities = 98/452 (21%), Positives = 170/452 (37%), Gaps = 77/452 (17%)
Query: 132 PRSVQSEPPTPKSETLTSEDAQPGSPLATGTDQVSLDKPLSSAAHLDDAAKMPSASSGEE 191
P+ V SE P E A+P P G + S + A+ K P+ASS E
Sbjct: 368 PQKVGSEQKEPPEEAEPVAAAEPEVPENNGNN--SWPHNDTEIANSTPNPK-PAASSPET 424
Query: 192 ADAGSLLPTTNELSQALAGADSLDSPP------RPLERSVGQLPS----------PPLLP 235
AG T++ AD PP R +++V +L PP
Sbjct: 425 PSAGQQEAKTDQ-------ADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSK 477
Query: 236 TPP-PKASSKTTKNVTGQATLFQASSMKSADPSLRGQLSTPTGSPHLTT---VHRPLPP- 290
TP P +SK + + Q + M L TPT +P + R P
Sbjct: 478 TPSSPCPASKVVRPLRTFLHTVQRNQM----------LMTPTSAPRSVMKSFIKRNTPLR 527
Query: 291 -----SRVIEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSF 345
S V +E R + ++++ Q R K KR + + ER ++
Sbjct: 528 MDPKCSFVEKERQRLENLRRKEEAEQLRRQKVEEDKRRRLEEVKLKREERLRK------- 580
Query: 346 DGALENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAV 405
L+ + + EE K+ + D+ EE L + K KK+ A
Sbjct: 581 --VLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEERLAEE--------KAKKKAAAK 630
Query: 406 KLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRND 465
K+ ++++ E+ R +E +E R Q ++ K Q + E + + +QR
Sbjct: 631 KMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLRKAAEAKRLAEQREQ 690
Query: 466 QTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDR-RADKPWTRL 524
+ ++ERRE ++R + Q E R+++ E + ++ +R +A++
Sbjct: 691 ERREQERREQERREQERREQ-----ERREQE-----RQLAEQERRREQERLQAERELQER 740
Query: 525 SAA---DKAAIRKELNEYKSNEMEVHASSKHL 553
A K +++EL E K E + + + L
Sbjct: 741 EKALRLQKEQLQRELEEKKKKEEQQRLAERQL 772
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 47.0 bits (110), Expect = 5e-05
Identities = 54/188 (28%), Positives = 80/188 (42%), Gaps = 37/188 (19%)
Query: 311 QGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENKENLIINS 370
+G++ K KKR ERGKERE E +R +E E K
Sbjct: 58 RGKKEKKKRKKR-----------ERGKERERKRK---EREKQRKERREKERRKR------ 97
Query: 371 ELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEER 430
+ E+ + G RK KKE K R R +KQ E R RR + R
Sbjct: 98 ---------KKEKKKRERKQRGRRERKKKKER---KERERENKQRRE-RKRKKRRKKKRR 144
Query: 431 QEIRQQIE--MKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQRPT 488
+E +++ E + KR ++ E +R K+R + E++ERRE K+ RK +R
Sbjct: 145 KERKREKERGKRERKRKKRKKEEREKKRERNRKERKKERERKERRERKKE--RKKERRKK 202
Query: 489 VDELRDRK 496
+ +DRK
Sbjct: 203 KERKKDRK 210
Score = 37.7 bits (86), Expect = 0.028
Identities = 24/79 (30%), Positives = 41/79 (51%), Gaps = 1/79 (1%)
Query: 408 RNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQT 467
R K+E +R R ++ER+ R + E K K+ +R E +R+ KQR ++
Sbjct: 32 RESERKKERREREKRKREREKERKRERGKKEKKKRKK-RERGKERERKRKEREKQRKERR 90
Query: 468 EQEERREIKQRLTRKLNQR 486
E+E R+ K++ R+ QR
Sbjct: 91 EKERRKRKKEKKKRERKQR 109
Score = 36.6 bits (83), Expect = 0.062
Identities = 33/156 (21%), Positives = 61/156 (39%)
Query: 396 RKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELE 455
R+ +KE + + K++ +R R +ER++ R++ K ++ + E +
Sbjct: 48 REREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRKRKKEKKKRERK 107
Query: 456 RRNILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDR 515
+R +++ + +E RE KQR RK +R ++RK K + +
Sbjct: 108 QRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEE 167
Query: 516 RADKPWTRLSAADKAAIRKELNEYKSNEMEVHASSK 551
R K K RKE E K + K
Sbjct: 168 REKKRERNRKERKKERERKERRERKKERKKERRKKK 203
Score = 34.3 bits (77), Expect = 0.31
Identities = 28/99 (28%), Positives = 48/99 (48%), Gaps = 2/99 (2%)
Query: 399 KKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRN 458
KKE + R R ++E + + +++E ++ E K +R QR E ERR
Sbjct: 37 KKERREREKRKREREKERKRERGKKEKKKRKKRERGKERERKRKEREKQRKERREKERRK 96
Query: 459 ILKQRND-QTEQEERREIKQRLTRKLNQRPTVDELRDRK 496
K++ + +Q RRE K++ RK +R + R+RK
Sbjct: 97 RKKEKKKRERKQRGRRERKKKKERKEREREN-KQRRERK 134
Score = 33.5 bits (75), Expect = 0.53
Identities = 33/168 (19%), Positives = 76/168 (45%), Gaps = 4/168 (2%)
Query: 392 GTLPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAV 451
G +K +K+ K R R K+ + R R ++ER++ +++ + + K+ +R
Sbjct: 59 GKKEKKKRKKRERGKERERKRKEREKQRK---ERREKERRKRKKEKKKRERKQRGRRERK 115
Query: 452 EELERRNILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQ 511
++ ER+ ++ N Q + +R++ +++ RK +R R+RK R + E + +
Sbjct: 116 KKKERKE-RERENKQRRERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRER 174
Query: 512 DYDRRADKPWTRLSAADKAAIRKELNEYKSNEMEVHASSKHLTRFHRP 559
+ R + + K +KE + K + + + ++ RP
Sbjct: 175 NRKERKKERERKERRERKKERKKERRKKKERKKDRKTDRQTDSQVFRP 222
>gi|16332372 cell division cycle 2-like 1 (PITSLRE proteins) isoform
9 [Homo sapiens]
Length = 771
Score = 46.6 bits (109), Expect = 6e-05
Identities = 62/260 (23%), Positives = 109/260 (41%), Gaps = 25/260 (9%)
Query: 294 IEELHRALATKHRQDSFQGRESKGSPK--KRLDVRLSRTSSVERGKEREEAWSFDGALEN 351
++ L L K R+ +E K K K D R S+ S+E G+ R+ + N
Sbjct: 10 VKTLDEILQEKKRRKE---QEEKAEIKRLKNSDDRDSKRDSLEEGELRDHCMEI--TIRN 64
Query: 352 KRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRP 411
++S E++ E D L + ++ + K K++ A R +
Sbjct: 65 SPYRREDSMEDR------GEEDDSLAIKPPQQMSRKEKVHHRKDEKRKEKKHA---RVKE 115
Query: 412 SKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLS--QRPAVEELERR--NILKQRNDQT 467
++E E R D+ R+E +Q ++++ S +R +E+LER+ K R Q
Sbjct: 116 KEREHERRKRHREEQDKARREWERQKRREMAREHSRRERDRLEQLERKRERERKMREQQK 175
Query: 468 EQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADK-PWTRLSA 526
EQ E++E ++R + +R E+ +R DY + KA + R + P R
Sbjct: 176 EQREQKERERRAEERRKEREARREVSAHHRTMR-EDYSDKVKASHWSRSPPRPPRERFEL 234
Query: 527 ADKAAIRKELNEYKSNEMEV 546
D RK + E K E ++
Sbjct: 235 GDG---RKPVKEEKMEERDL 251
>gi|118572613 splicing coactivator subunit SRm300 [Homo sapiens]
Length = 2752
Score = 46.2 bits (108), Expect = 8e-05
Identities = 88/394 (22%), Positives = 133/394 (33%), Gaps = 64/394 (16%)
Query: 6 DGSGCLVSRGRSQSDPSVL----TDSSATSSADAGENPDEMDQTPPARPEYLVSGIRTPP 61
DGSG S S P + T S S D+ P + QTP R R+P
Sbjct: 1449 DGSGTPSRHSLSGSSPGMKDIPRTPSRGRSECDSSPEPKALPQTPRPRS-------RSPS 1501
Query: 62 VRR-NSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAGRQGREELIKKGLLEMMEQD 120
N+K T P + R + Q T A + G++ R
Sbjct: 1502 SPELNNKCLT------PQRERSGSESSVDQKTVA--RTPLGQRSRSG------------S 1541
Query: 121 AESKTCNPDGGP--RSVQSEPPTPKSETLTSEDAQPGSPLATGTDQVSLDKPL-----SS 173
++ P P RS P K++T T + S + D S P SS
Sbjct: 1542 SQELDVKPSASPQERSESDSSPDSKAKTRTPLRQRSRSGSSPEVDSKSRLSPRRSRSGSS 1601
Query: 174 AAHLDDAAKMPSASSGEEADAGSLLPTTNELSQ-------------ALAGADSLDSPP-- 218
D P A SG ++ P L + + G+ S +S P
Sbjct: 1602 PEVKDKPRAAPRAQSGSDSSPEPKAPAPRALPRRSRSGSSSKGRGPSPEGSSSTESSPEH 1661
Query: 219 ----RPLERSVGQLPSPPLLP-TPPPKASSKTTKNVTGQATLFQASSMKSADPSLRGQLS 273
R R P P TPP + SS+++ +T +A L + S S+ P R +
Sbjct: 1662 PPKSRTARRGSRSSPEPKTKSRTPPRRRSSRSSPELTRKARLSRRSRSASSSPETRSR-- 1719
Query: 274 TPTGSPHLTTVHRPLPPSRVIEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSV 333
TP +V P P + R A+ R + R SPK R L R+ S
Sbjct: 1720 TPPRHRRSPSVSSPEPAEKSRSSRRRRSASSPRTKTTSRRGRSPSPKPR---GLQRSRSR 1776
Query: 334 ERGKEREEAWSFDGALENKRTAAKESEENKENLI 367
R ++ D + ++ T+ + + +
Sbjct: 1777 SRREKTRTTRRRDRSGSSQSTSRRRQRSRSRSRV 1810
Score = 43.9 bits (102), Expect = 4e-04
Identities = 46/239 (19%), Positives = 88/239 (36%), Gaps = 22/239 (9%)
Query: 2 AASEDGSGCLVSRGRSQSDPSVLTDSS-ATSSADAGENPDEMDQTPPARPEYLVSGIRTP 60
+A D S CL+++ + L+ + AT+++ AG++ + P P S + P
Sbjct: 2453 SAFSDQSRCLIAQTTPVAGSQSLSSGAVATTTSSAGDHNGMLSVPAPGVPH---SDVGEP 2509
Query: 61 PVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAGRQGREELIKKGLLEMMEQD 120
P ++ + +P K R+ + ++S+ + + +
Sbjct: 2510 PASTGAQQPSALAALQPAKERRSSSSSSSSSSSSSSSSSSSSSSSSSGSSSS-----DSE 2564
Query: 121 AESKTCNPDGGPRSVQSEPPTPKSETLTSEDAQPGSPLATGTDQVSLDKPLSSAAHLDDA 180
S P+ + V S P PK + +P P + S SS+
Sbjct: 2565 GSSLPVQPEVALKRVPSPTPAPKEAV---REGRPPEPTPAKRKRRSSSSSSSSS------ 2615
Query: 181 AKMPSASSGEEADAGSLLPTTNELSQALAGADSLDSPPRPLERSVGQLPSPPLLPTPPP 239
S+SS + + S +++ S + + + S S P P + LP P PPP
Sbjct: 2616 ----SSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSSPSPAKPGPQALPKPASPKKPPP 2670
Score = 34.3 bits (77), Expect = 0.31
Identities = 53/258 (20%), Positives = 90/258 (34%), Gaps = 27/258 (10%)
Query: 31 SSADAGENPDEMDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKKNEKLKQ 90
S + A + +TP R S RTP R S+ T R R + ++
Sbjct: 637 SRSPARRSGRSRSRTPARRGR---SRSRTPARRGRSRSRTPARR----SGRSRSRTPARR 689
Query: 91 TTSALEKKMAGRQGREELIKKGLLEMME--------QDAESKTCNPDGGPRSVQSEPPTP 142
S GR L+++G +E K + RS + P
Sbjct: 690 GRSRSRTPRRGRSRSRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEM 749
Query: 143 KSETLTSEDAQP-GSPLATGTDQVSLDKPLSSAAHLDDAAKMPSASSGEEADAGSLLPTT 201
K ++S ++ SP + ++SL + LS ++ K S + + +GS P
Sbjct: 750 KKSRISSRRSRSLSSPRSKAKSRLSLRRSLSGSS---PCPKQKSQTPPRRSRSGSSQPKA 806
Query: 202 NELSQALAGADSLDSPPRPLERSVGQL------PSPPLLPTPPPKASSKTTKNVTGQATL 255
+ S PP+ ++ + P P + PP+ S T+ Q+
Sbjct: 807 KSRTPPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSPQANEQSVT 866
Query: 256 FQASSM--KSADPSLRGQ 271
Q S S DP L+ +
Sbjct: 867 PQRRSCFESSPDPELKSR 884
Score = 30.4 bits (67), Expect = 4.5
Identities = 57/242 (23%), Positives = 91/242 (37%), Gaps = 30/242 (12%)
Query: 8 SGCLVSRGRSQS-DPSVLTDSSATSSADAGENPDEMDQTPPARPEYLVSGIRTPPVRRNS 66
S LV RGRS S P S ++S + + PE S I + RR+
Sbjct: 704 SRSLVRRGRSHSRTPQRRGRSGSSSERKNKSRTSQRRSRSNSSPEMKKSRISS---RRSR 760
Query: 67 KLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAGRQGREELIKKGLLEMMEQDAESKTC 126
L++ R K +L S +Q + ++ + A+S+T
Sbjct: 761 SLSSP---------RSKAKSRLSLRRSLSGSSPCPKQKSQTPPRRSRSGSSQPKAKSRT- 810
Query: 127 NPDGGPRSVQSEPPTPKSETLTSEDAQPGSP---LATGTD--QVSLDKPLSSAAHLDDAA 181
P RS S PP KS+T + + SP + +GT Q S+ P ++ +
Sbjct: 811 -PPRRSRSSSSPPPKQKSKTPSRQSHSSSSPHPKVKSGTPPRQGSITSP-----QANEQS 864
Query: 182 KMPSASSGEEADAGSLLPTTNELSQALAGADSLDSPPRPLERSVGQLPSPPLLPTPPPKA 241
P S E+ L + + +G+ SPPR ++ S SP +P PK
Sbjct: 865 VTPQRRSCFESSPDPELKSRTPSRHSCSGS----SPPR-VKSSTPPRQSPSRSSSPQPKV 919
Query: 242 SS 243
+
Sbjct: 920 KA 921
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 45.8 bits (107), Expect = 1e-04
Identities = 43/184 (23%), Positives = 78/184 (42%), Gaps = 7/184 (3%)
Query: 307 QDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENKENL 366
++ + RE + ++ + R ER +ERE + + KR ++ E+ E
Sbjct: 385 REKSRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYERR 444
Query: 367 IINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFPRRT 426
+ +L++ YQ E N I R+ +KE + R R +E + F
Sbjct: 445 KLERKLREKEAAYQ-ERLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDY 503
Query: 427 DEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQR 486
D++R + + L KRL R E + +R+ + E+EE EI+QRL + +
Sbjct: 504 DDDRDDPKYYRGSALQKRLRDREKEMEAD------ERDRKREKEELEEIRQRLLAEGHPD 557
Query: 487 PTVD 490
P +
Sbjct: 558 PDAE 561
Score = 45.4 bits (106), Expect = 1e-04
Identities = 46/167 (27%), Positives = 71/167 (42%), Gaps = 12/167 (7%)
Query: 326 RLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQDEEAL 385
RL ER K RE + E +R AKE++ KE L + +DD Y+ AL
Sbjct: 460 RLKNWEIRERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGS-AL 518
Query: 386 NDSIISGTLPRKCKKELLAVKLRNRPSKQELED--RNIFPRR---TDEERQEIRQQIEMK 440
+ R +KE+ A + + K+ELE+ + + D E Q + Q+ E +
Sbjct: 519 QKRL------RDREKEMEADERDRKREKEELEEIRQRLLAEGHPDPDAELQRMEQEAERR 572
Query: 441 LSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQRP 487
++ Q P EE E K+ + EE E +Q+ K RP
Sbjct: 573 RQPQIKQEPESEEEEEEKQEKEEKREEPMEEEEEPEQKPCLKPTLRP 619
Score = 42.4 bits (98), Expect = 0.001
Identities = 58/263 (22%), Positives = 105/263 (39%), Gaps = 11/263 (4%)
Query: 285 HRPLPPSRVIEELHRALATKHRQDSFQGRESKGSPKKRLDVR---LSRTSSVERGKEREE 341
H+ L + +E R K R++ + RE + ++R R R ER +ERE
Sbjct: 288 HKKLEEEKGKKEKERQEIEKERRERERERERERERREREREREREREREKEKERERERER 347
Query: 342 AWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQ---DEEALNDSIISGTLPRKC 398
D E R +E + +++ + KD + D E + R+
Sbjct: 348 DRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKSRDRERERERERERERERER 407
Query: 399 KKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKR---LSQRPAVEELE 455
++E + R R ++E E R DEE R+++E KL ++ +R E+
Sbjct: 408 EREREREREREREREREREKDKKRDREEDEEDAYERRKLERKLREKEAAYQERLKNWEIR 467
Query: 456 RRNILKQRNDQTEQEE--RREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDY 513
R ++ + E+EE RRE+ + R D+ RD R S + + ++
Sbjct: 468 ERKKTREYEKEAEREEERRREMAKEAKRLKEFLEDYDDDRDDPKYYRGSALQKRLRDREK 527
Query: 514 DRRADKPWTRLSAADKAAIRKEL 536
+ AD+ + + IR+ L
Sbjct: 528 EMEADERDRKREKEELEEIRQRL 550
Score = 42.4 bits (98), Expect = 0.001
Identities = 53/236 (22%), Positives = 94/236 (39%), Gaps = 36/236 (15%)
Query: 304 KHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENK 363
K RQ+ + R + ++R R R ER +ERE+ + E R + E ++
Sbjct: 300 KERQEIEKERRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDR 359
Query: 364 ENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFP 423
+ + E D +D E +D RN+ + E
Sbjct: 360 DR---DRERDRD----RDRERSSD--------------------RNKDRSRSREKSRDRE 392
Query: 424 RRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKL 483
R + ER+ R++ + +R +R E ER ++ D+ E EE +++L RKL
Sbjct: 393 REREREREREREREREREREREREREREREREREK--DKKRDREEDEEDAYERRKLERKL 450
Query: 484 NQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAAIRKELNEY 539
++ + R + IR E K ++Y++ A++ R K A K L E+
Sbjct: 451 REKEAAYQERLKNWEIR-----ERKKTREYEKEAEREEERRREMAKEA--KRLKEF 499
Score = 36.2 bits (82), Expect = 0.082
Identities = 31/148 (20%), Positives = 74/148 (50%), Gaps = 12/148 (8%)
Query: 395 PRKCKKELLAVKL----RNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPA 450
P K+++ A+++ R+ S++ + R+ + +E+ ++ +++ E++ +R +R
Sbjct: 257 PLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKERRERERER 316
Query: 451 VEELERRNILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKA 510
E ERR ++R + E+E+ +E ++ R ++ T + RDR E +
Sbjct: 317 ERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRD--------RERDRD 368
Query: 511 QDYDRRADKPWTRLSAADKAAIRKELNE 538
+D +R +D+ R + +K+ R+ E
Sbjct: 369 RDRERSSDRNKDRSRSREKSRDRERERE 396
>gi|66529407 tensin [Homo sapiens]
Length = 1735
Score = 45.8 bits (107), Expect = 1e-04
Identities = 71/261 (27%), Positives = 107/261 (40%), Gaps = 31/261 (11%)
Query: 40 DEMDQTPPARPEYLVSGIRTPPVRRNSKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKM 99
+EM+ T P+ P SG+R+PP + L+ LG KP + L T +++
Sbjct: 954 EEMEGTSPSSPP--PSGVRSPPGLAKTPLSALG--LKP----HNPADILLHPTGVTRRRI 1005
Query: 100 AGRQGREELIKKGLLEMMEQDAESKTCNPDGGPRSVQSEPPT---PKSETLTSEDAQPGS 156
+ +++ + L E ES GPR+ SEP + P ++ E
Sbjct: 1006 QPEEDEGKVVVR-LSEEPRSYVESVARTAVAGPRAQDSEPKSFSAPATQAYGHE-----I 1059
Query: 157 PLATGTDQVSL--DKPLSSAAHL--DDAAKMPSASSGEEADAGSLLPTTNELSQALAGAD 212
PL GT S PLS+++ + D+ + S SGE +D G PT L +
Sbjct: 1060 PLRNGTLGGSFVSPSPLSTSSPILSADSTSVGSFPSGESSDQGPRTPTQPLLESGFR-SG 1118
Query: 213 SLDSPPRPLERSVGQLPSPPLLPTPPPKASSKTTKNVTGQATLFQASSMKSADPSLRGQL 272
SL P +R+ S PL P SS ++ + + Q S A S+ G
Sbjct: 1119 SLGQPSPSAQRNYQS--SSPL----PTVGSSYSSPDYSLQHFSSSPESQARAQFSVAGVH 1172
Query: 273 STPTGSPHL--TTVHRPLPPS 291
+ P GSP TV PPS
Sbjct: 1173 TVP-GSPQARHRTVGTNTPPS 1192
Score = 30.0 bits (66), Expect = 5.8
Identities = 41/171 (23%), Positives = 69/171 (40%), Gaps = 21/171 (12%)
Query: 17 SQSDPSVLTDSSATSSADAGENPDEMDQTPPARPEYLVSGIR-------TPPVRRN---- 65
S S P + DS++ S +GE+ D+ +TP L SG R +P +RN
Sbjct: 1077 STSSPILSADSTSVGSFPSGESSDQGPRTP--TQPLLESGFRSGSLGQPSPSAQRNYQSS 1134
Query: 66 SKLATLGRIFKPWKWRKKKNEKLKQTTSALEKKMAGRQGREELIKKGLLEMMEQDAESKT 125
S L T+G + + + ++ + + +AG G + + + T
Sbjct: 1135 SPLPTVGSSYSSPDYSLQHFSSSPESQARAQFSVAGVH-----TVPGSPQARHRTVGTNT 1189
Query: 126 -CNPDGGPRSVQSEPPTPKSETLTSEDAQPGSPLATGTDQVSLDKPLSSAA 175
+P G R++ P S +L+ Q P TG ++ P SSAA
Sbjct: 1190 PPSPGFGWRAINPSMAAPSSPSLSHH--QMMGPPGTGFHGSTVSSPQSSAA 1238
>gi|197333879 genetic suppressor element 1 isoform 2 [Homo sapiens]
Length = 1113
Score = 45.8 bits (107), Expect = 1e-04
Identities = 73/276 (26%), Positives = 120/276 (43%), Gaps = 45/276 (16%)
Query: 217 PPRPLERSVGQLPSPPLLPTPPPKAS--SKTTKNVTGQ--ATLFQASSMKSADPSLRGQL 272
PP P R G L P LP P P + K+T+ + GQ A+L QA++ G+L
Sbjct: 547 PPPPPPREGGSLEHQPFLPGPGPFLAELEKSTQTILGQQRASLPQAATF--------GEL 598
Query: 273 STP--TGSPHLTTVHRPLPPSRVIEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRT 330
S P GSP+ V R P+ + +E L + R S +LD+ R
Sbjct: 599 SGPLKPGSPYRPPVPRAPDPAYIYDEF---LQQRRRLVS------------KLDLEERR- 642
Query: 331 SSVERGKEREEAWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSII 390
R + +E+ + +D L++ + E EE + +L +E + L L E L +
Sbjct: 643 ----RREAQEKGYYYD--LDDSYDESDE-EEVRAHLRCVAE-QPPLKLDTSSEKLEFLQL 694
Query: 391 SGTLPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKL---SKRLSQ 447
G ++ K+EL+A K R R ++ L +R+ P +RQ ++ + ++
Sbjct: 695 FGLTTQQQKEELVAQKRRKR--RRMLRERSPSPPTIQSKRQTPSPRLALSTRYSPDEMNN 752
Query: 448 RPAVEELERRNILKQRNDQTEQEERREIKQRLTRKL 483
P E E++ L N E+R+ K+RL L
Sbjct: 753 SPNFE--EKKKFLTIFNLTHISAEKRKDKERLVEML 786
Score = 32.0 bits (71), Expect = 1.5
Identities = 22/72 (30%), Positives = 36/72 (50%), Gaps = 1/72 (1%)
Query: 427 DEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQR 486
DEE + R++ + +R + R +E ER K+R + E+E +E ++ L R+ QR
Sbjct: 230 DEELRREREREREREREREADREREKERERERE-KEREQEKEREREKERERELERQREQR 288
Query: 487 PTVDELRDRKIL 498
EL K L
Sbjct: 289 AREKELLAAKAL 300
>gi|44955926 genetic suppressor element 1 isoform 1 [Homo sapiens]
Length = 1217
Score = 45.8 bits (107), Expect = 1e-04
Identities = 73/276 (26%), Positives = 120/276 (43%), Gaps = 45/276 (16%)
Query: 217 PPRPLERSVGQLPSPPLLPTPPPKAS--SKTTKNVTGQ--ATLFQASSMKSADPSLRGQL 272
PP P R G L P LP P P + K+T+ + GQ A+L QA++ G+L
Sbjct: 651 PPPPPPREGGSLEHQPFLPGPGPFLAELEKSTQTILGQQRASLPQAATF--------GEL 702
Query: 273 STP--TGSPHLTTVHRPLPPSRVIEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRT 330
S P GSP+ V R P+ + +E L + R S +LD+ R
Sbjct: 703 SGPLKPGSPYRPPVPRAPDPAYIYDEF---LQQRRRLVS------------KLDLEERR- 746
Query: 331 SSVERGKEREEAWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSII 390
R + +E+ + +D L++ + E EE + +L +E + L L E L +
Sbjct: 747 ----RREAQEKGYYYD--LDDSYDESDE-EEVRAHLRCVAE-QPPLKLDTSSEKLEFLQL 798
Query: 391 SGTLPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKL---SKRLSQ 447
G ++ K+EL+A K R R ++ L +R+ P +RQ ++ + ++
Sbjct: 799 FGLTTQQQKEELVAQKRRKR--RRMLRERSPSPPTIQSKRQTPSPRLALSTRYSPDEMNN 856
Query: 448 RPAVEELERRNILKQRNDQTEQEERREIKQRLTRKL 483
P E E++ L N E+R+ K+RL L
Sbjct: 857 SPNFE--EKKKFLTIFNLTHISAEKRKDKERLVEML 890
Score = 32.0 bits (71), Expect = 1.5
Identities = 22/72 (30%), Positives = 36/72 (50%), Gaps = 1/72 (1%)
Query: 427 DEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQR 486
DEE + R++ + +R + R +E ER K+R + E+E +E ++ L R+ QR
Sbjct: 334 DEELRREREREREREREREADREREKERERERE-KEREQEKEREREKERERELERQREQR 392
Query: 487 PTVDELRDRKIL 498
EL K L
Sbjct: 393 AREKELLAAKAL 404
>gi|148746195 trichohyalin [Homo sapiens]
Length = 1943
Score = 45.4 bits (106), Expect = 1e-04
Identities = 42/183 (22%), Positives = 86/183 (46%), Gaps = 10/183 (5%)
Query: 304 KHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENK 363
+H Q+ + + + ++R + L R ++ E +R + +E +
Sbjct: 466 RHEQERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEE 525
Query: 364 ENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFP 423
E L L+ + L +++E + + L R+ +K L + R +++ E R+
Sbjct: 526 ERL--QQRLRSEQQLRREQEERREQL----LKREEEKRLEQERREQRLKREQEERRDQLL 579
Query: 424 RRTDEERQE-IRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRK 482
+R +E RQ+ ++++ E +L +RL +R VE LE+ +QR + E EE R +Q+L +
Sbjct: 580 KREEERRQQRLKREQEERLEQRL-KREEVERLEQEERREQRLKREEPEEER--RQQLLKS 636
Query: 483 LNQ 485
Q
Sbjct: 637 EEQ 639
Score = 43.9 bits (102), Expect = 4e-04
Identities = 37/192 (19%), Positives = 82/192 (42%), Gaps = 9/192 (4%)
Query: 304 KHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKE--------REEAWSFDGALENKRTA 355
+ +++ + R + ++RL RL + R +E REE + +R
Sbjct: 509 REQEERREQRLKRQEEEERLQQRLRSEQQLRREQEERREQLLKREEEKRLEQERREQRLK 568
Query: 356 AKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQE 415
++ E + L E + L + EE L + + R ++E +L+ ++E
Sbjct: 569 REQEERRDQLLKREEERRQQRLKREQEERLEQRLKREEVERLEQEERREQRLKREEPEEE 628
Query: 416 LEDRNIFPRRTDEERQ-EIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERRE 474
+ + +E RQ ++R++ + + +RL + E LE+R + ++ EQE E
Sbjct: 629 RRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQELAEE 688
Query: 475 IKQRLTRKLNQR 486
+++ ++ R
Sbjct: 689 EQEQARERIKSR 700
Score = 41.6 bits (96), Expect = 0.002
Identities = 48/252 (19%), Positives = 108/252 (42%), Gaps = 35/252 (13%)
Query: 295 EELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRT 354
E+L R K R+ + + + ++ + +L R +R +ERE + + L+ ++
Sbjct: 1151 EQLLREEPEKRRRQELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKR 1210
Query: 355 AAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQ 414
+ +E++ S+LK ++ ++ + + ++L +LR+R S+Q
Sbjct: 1211 KQRYRDEDQR-----SDLKWQWEPEKENAVRDNKVYCKGRENEQFRQLEDSQLRDRQSQQ 1265
Query: 415 ELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERRE 474
+L+ E+++ R+Q + +R P E+LER EE++E
Sbjct: 1266 DLQ------HLLGEQQERDREQERRRWQQRDRHFPEEEQLER-------------EEQKE 1306
Query: 475 IKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAAIRK 534
K+R + ++ + E R+ K + Q+ DR+ + L ++ +R+
Sbjct: 1307 AKRRDRKSQEEKQLLREEREEK-----------RRRQETDRKFREEEQLLQEREEQPLRR 1355
Query: 535 ELNEYKSNEMEV 546
+ + K E E+
Sbjct: 1356 QERDRKFREEEL 1367
Score = 41.2 bits (95), Expect = 0.003
Identities = 47/243 (19%), Positives = 104/243 (42%), Gaps = 26/243 (10%)
Query: 304 KHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENK 363
+ +Q+ + +E + + R + R + R +E E E + +E E +
Sbjct: 322 REQQERREQQEERREQQLRREQEERREQQLRREQEEERR-------EQQLRREQEEERRE 374
Query: 364 ENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFP 423
+ L +L+ + L ++++ + ++ ++E + + +Q+L
Sbjct: 375 QQLRREQQLRREQQLRREQQLRRE--------QQLRREQQLRREQQLRREQQLRREQQLR 426
Query: 424 RRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKL 483
R +EER E + + E R QR E+ ERR+ LK R ++TE+ E+ KQ+L
Sbjct: 427 REQEEERHEQKHEQE-----RREQRLKREQEERRDWLK-REEETERHEQERRKQQL---- 476
Query: 484 NQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAAIRKELNEYKSNE 543
+R +E R+R + + + E + ++ R ++ R + + L + +E
Sbjct: 477 -KRDQEEERRERWLKLEEEERREQQERREQQLRREQEERREQRLKRQEEEERLQQRLRSE 535
Query: 544 MEV 546
++
Sbjct: 536 QQL 538
Score = 40.4 bits (93), Expect = 0.004
Identities = 43/222 (19%), Positives = 98/222 (44%), Gaps = 16/222 (7%)
Query: 295 EELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKE----------REEAWS 344
EE + +Q+ + ++ + ++R + +L R ER ++ RE+
Sbjct: 319 EERREQQERREQQEERREQQLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLR 378
Query: 345 FDGALENKRTAAKESEENKEN-LIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELL 403
+ L ++ +E + +E L +L+ + L ++++ + + + ++
Sbjct: 379 REQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKH 438
Query: 404 AVKLRNRPSKQELEDRNIFPRRTDE----ERQEIRQQIEMKLSKRLSQR-PAVEELERRN 458
+ R + K+E E+R + +R +E E++ +QQ++ + +R +EE ERR
Sbjct: 439 EQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRERWLKLEEEERRE 498
Query: 459 ILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIR 500
++R Q +E+ +QRL R+ + LR + L R
Sbjct: 499 QQERREQQLRREQEERREQRLKRQEEEERLQQRLRSEQQLRR 540
Score = 40.4 bits (93), Expect = 0.004
Identities = 49/210 (23%), Positives = 88/210 (41%), Gaps = 15/210 (7%)
Query: 295 EELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRT 354
EE + L Q+ + ++ + ++R + RL R ER ++R + + E +
Sbjct: 627 EERRQQLLKSEEQEERRQQQLRREQQERREQRLKREEEEERLEQRLKREHEEERREQE-- 684
Query: 355 AAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKC----KKELLAVKLRNR 410
A+E +E I + K L + +A + S PRK +++ K R R
Sbjct: 685 LAEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSR--PRKQEGQRRRQEQEEKRRRR 742
Query: 411 PSKQELEDRNIFPRRTDEERQEI----RQQIEMKLSK---RLSQRPAVEELERRNILKQR 463
S+ + ++ R+ EE Q + Q E K + RLS RP + E R + +
Sbjct: 743 ESELQWQEEERAHRQQQEEEQRRDFTWQWQAEEKSERGRQRLSARPPLREQRERQLRAEE 802
Query: 464 NDQTEQEERREIKQRLTRKLNQRPTVDELR 493
Q EQ E +++ R+ +R EL+
Sbjct: 803 RQQREQRFLPEEEEKEQRRRQRREREKELQ 832
Score = 40.4 bits (93), Expect = 0.004
Identities = 50/242 (20%), Positives = 92/242 (38%), Gaps = 31/242 (12%)
Query: 311 QGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSF-----DGALENKRTAAKESEENKEN 365
Q RE K ++ L + ER K R + W D + + +E E +
Sbjct: 984 QEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLREEREKRRL 1043
Query: 366 LIINSELKDDLLLYQDEEAL----NDSIISGTLPRKCKKELLAVK-----LRNRPSKQEL 416
+ +++ L Q+EE L ++ L R+ +KE + LR P K+
Sbjct: 1044 QERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLREEPEKRRR 1103
Query: 417 EDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIK 476
++R R +E +QE Q + + KR Q + E + ++ +E + +
Sbjct: 1104 QERERQCREEEELQQEEEQLLREEREKRRRQELERQYREEEEVQQEEEQLLREEPEKRRR 1163
Query: 477 QRLTRKLNQRPTVD--------ELRDRKILIRFSDYVEVAKAQ---------DYDRRADK 519
Q L R+ + + E ++++ R Y E + Q D D+R+D
Sbjct: 1164 QELERQYREEEELQQEEEQLLREEQEKRRQERERQYREEEELQRQKRKQRYRDEDQRSDL 1223
Query: 520 PW 521
W
Sbjct: 1224 KW 1225
Score = 40.0 bits (92), Expect = 0.006
Identities = 50/258 (19%), Positives = 109/258 (42%), Gaps = 35/258 (13%)
Query: 306 RQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENKEN 365
R++ + + K ++RL+ RL R VER ++ E +R +E EE +
Sbjct: 581 REEERRQQRLKREQEERLEQRLKR-EEVERLEQEER--------REQRLKREEPEEERRQ 631
Query: 366 LIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFPRR 425
++ SE +++ Q + L R+ ++E L +L K+E E+
Sbjct: 632 QLLKSEEQEERRQQQLRREQQERR-EQRLKREEEEERLEQRL-----KREHEEERREQEL 685
Query: 426 TDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQ 485
+EE+++ R++I+ ++ K Q + + + + + Q Q R+E +++ R+ ++
Sbjct: 686 AEEEQEQARERIKSRIPKWQWQLESEADARQSKVYSRPRKQEGQRRRQEQEEKRRRRESE 745
Query: 486 RPTVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKA-------AIRKELNE 538
+E R + + Q+ ++R D W + A +K+ + R L E
Sbjct: 746 LQWQEEERAHR------------QQQEEEQRRDFTW-QWQAEEKSERGRQRLSARPPLRE 792
Query: 539 YKSNEMEVHASSKHLTRF 556
+ ++ + RF
Sbjct: 793 QRERQLRAEERQQREQRF 810
Score = 39.7 bits (91), Expect = 0.007
Identities = 47/211 (22%), Positives = 97/211 (45%), Gaps = 35/211 (16%)
Query: 295 EELHRALATKHRQDSFQGRESKGSP-----KKRLDVRLSRTSSVERGKEREEAWSFDGAL 349
+E A + + S +G E++ P ++R + L R E+ ++R E
Sbjct: 181 QEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKGREEKQQQRRE-------- 232
Query: 350 ENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRN 409
++ + EE KE K + +L ++EE L + + ++E L
Sbjct: 233 --RQDRVFQEEEEKE------WRKRETVLRKEEEKLQEEEPQRQRELQEEEEQL------ 278
Query: 410 RPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQ 469
++LE + + R +EE+Q+ R + E +L ++ + ++ ERR ++R Q E+
Sbjct: 279 ----RKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEER 334
Query: 470 EE---RREIKQRLTRKLNQRPTVDELRDRKI 497
E RRE ++R ++L +R +E R++++
Sbjct: 335 REQQLRREQEERREQQL-RREQEEERREQQL 364
Score = 39.3 bits (90), Expect = 0.010
Identities = 45/196 (22%), Positives = 85/196 (43%), Gaps = 18/196 (9%)
Query: 295 EELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGAL----E 350
++L R + Q + ++ + + R + +L R ER +++ E + L E
Sbjct: 393 QQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQEEERHEQKHEQERREQRLKREQE 452
Query: 351 NKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNR 410
+R K EE + + K L Q+EE + R+ ++E +LR
Sbjct: 453 ERRDWLKREEETERHE--QERRKQQLKRDQEEERRERWLKLEEEERREQQERREQQLR-- 508
Query: 411 PSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQE 470
+E E+R + EE + ++Q++ + R Q E R +LK+ ++ ++
Sbjct: 509 ---REQEERREQRLKRQEEEERLQQRLRSEQQLRREQ-----EERREQLLKREEEKRLEQ 560
Query: 471 ERREIKQRLTRKLNQR 486
ERRE QRL R+ +R
Sbjct: 561 ERRE--QRLKREQEER 574
Score = 38.9 bits (89), Expect = 0.013
Identities = 42/181 (23%), Positives = 78/181 (43%), Gaps = 25/181 (13%)
Query: 400 KELLAVKLRNRPSKQELEDRNIFPRRTDEE----RQEIRQQIEMKLSKRLSQRPAVEELE 455
KE L R ++ E R+ R+ +EE R++ RQ+ E +L++ Q E LE
Sbjct: 106 KESLLQDRRQEEDQRRFEPRD---RQLEEEPGQRRRQKRQEQERELAEGEEQSEKQERLE 162
Query: 456 RRN-------ILKQRNDQTEQEERREIKQRLT----RKLNQRPTVDELRDRKILI----- 499
+R+ + +QR + E+EERR +++L + + P ++LR R++L
Sbjct: 163 QRDRQRRDEELWRQRQEWQEREERRAEEEQLQSCKGHETEEFPDEEQLRRRELLELRRKG 222
Query: 500 RFSDYVEVAKAQD--YDRRADKPWTRLSAADKAAIRKELNEYKSNEMEVHASSKHLTRFH 557
R + + QD + +K W + + K E + E+ + L +
Sbjct: 223 REEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLE 282
Query: 558 R 558
R
Sbjct: 283 R 283
Score = 38.9 bits (89), Expect = 0.013
Identities = 45/224 (20%), Positives = 91/224 (40%), Gaps = 21/224 (9%)
Query: 335 RGKEREEAWSFDGALENKRTAA-KESEENKENLIINSELKDDLLLYQDEEALNDSIISGT 393
R +E+E + + L+ + +E E + + + D L Q EE L G
Sbjct: 922 RRQEQERQYREEEQLQQEEEQLLREEREKRRRQERERQYRKDKKLQQKEEQL-----LGE 976
Query: 394 LPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEE 453
P K +++ K R Q+ E++ + R RQE +Q K + + + E
Sbjct: 977 EPEKRRRQEREKKYREEEELQQEEEQLLREEREKRRRQEWERQYRKKDELQQEEEQLLRE 1036
Query: 454 LERRNILKQRNDQTEQE------------ERREIKQRLTRKLNQRPTVDELRDRKILIRF 501
+ L++R Q +E E RE ++R + R + ++ + L+R
Sbjct: 1037 EREKRRLQERERQYREEEELQQEEEQLLGEERETRRRQELERQYRKEEELQQEEEQLLR- 1095
Query: 502 SDYVEVAKAQDYDRRADKPWTRLSAADKAAIRKELNEYKSNEME 545
+ E + Q+ +R+ + L ++ +R+E + + E+E
Sbjct: 1096 -EEPEKRRRQERERQC-REEEELQQEEEQLLREEREKRRRQELE 1137
Score = 38.5 bits (88), Expect = 0.016
Identities = 53/217 (24%), Positives = 95/217 (43%), Gaps = 41/217 (18%)
Query: 295 EELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRT 354
EE H KH Q+ + R + ++R ++ + + R++ D E +
Sbjct: 431 EERHEQ---KHEQERREQRLKREQEERRDWLKREEETERHEQERRKQQLKRDQEEERRER 487
Query: 355 AAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQ 414
K EE + E ++ L + EE L R+ ++E L +LR S+Q
Sbjct: 488 WLKLEEEERRE---QQERREQQLRREQEERREQR-----LKRQEEEERLQQRLR---SEQ 536
Query: 415 ELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERR----------NILKQRN 464
+L RR EER+E Q ++ + KRL Q E E+R +LK+
Sbjct: 537 QL-------RREQEERRE--QLLKREEEKRLEQ----ERREQRLKREQEERRDQLLKREE 583
Query: 465 DQTEQEERRE----IKQRLTRKLNQRPTVDELRDRKI 497
++ +Q +RE ++QRL R+ +R +E R++++
Sbjct: 584 ERRQQRLKREQEERLEQRLKREEVERLEQEERREQRL 620
Score = 38.1 bits (87), Expect = 0.021
Identities = 45/196 (22%), Positives = 85/196 (43%), Gaps = 12/196 (6%)
Query: 311 QGRESKGSPKKRLDVRLSRTSSVERGKEREEAW--SFDGALENKRTAAKESEENKENL-- 366
+GRE K ++ R+ + + ++RE + E + +E +E +E L
Sbjct: 221 KGREEKQQQRRERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRK 280
Query: 367 IINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQEL-----EDRNI 421
+ EL+ + Q+EE + R+ ++E + R +QE E R
Sbjct: 281 LERQELRRER---QEEEQQQQRLRREQQLRRKQEEERREQQEERREQQERREQQEERREQ 337
Query: 422 FPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTR 481
RR EER+E + + E + +R Q +E ERR +R Q +E++ +Q+L R
Sbjct: 338 QLRREQEERREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRR 397
Query: 482 KLNQRPTVDELRDRKI 497
+ R R++++
Sbjct: 398 EQQLRREQQLRREQQL 413
Score = 37.7 bits (86), Expect = 0.028
Identities = 48/206 (23%), Positives = 94/206 (45%), Gaps = 24/206 (11%)
Query: 295 EELHRALATKHRQDSFQGRES-KGSPKKRLDVRLSRTSSVERGKE--REEAWSFDGALEN 351
++L R + R+ + + + + R + +L R + R ++ RE+ + L
Sbjct: 362 QQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 421
Query: 352 KRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRP 411
++ +E EE + E ++ L + EE + L R+ + E + R +
Sbjct: 422 EQQLRREQEEERHEQKHEQERREQRLKREQEERRD------WLKREEETERHEQERRKQQ 475
Query: 412 SK--QELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQ 469
K QE E R + + +EER+E +++ E +L + E+ ERR +QR + E+
Sbjct: 476 LKRDQEEERRERWLKLEEEERREQQERREQQLRR--------EQEERR---EQRLKRQEE 524
Query: 470 EERREIKQRLTRKLNQRPTVDELRDR 495
EER ++QRL + R +E R++
Sbjct: 525 EER--LQQRLRSEQQLRREQEERREQ 548
Score = 37.0 bits (84), Expect = 0.048
Identities = 51/266 (19%), Positives = 106/266 (39%), Gaps = 36/266 (13%)
Query: 291 SRVIEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALE 350
S+V + + RQ+ + R + S + + + E + R+ W +
Sbjct: 717 SKVYSRPRKQEGQRRRQEQEEKRRRRESELQWQEEERAHRQQQEEEQRRDFTWQWQ---- 772
Query: 351 NKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNR 410
A ++SE ++ L L++ Q E L +E + R
Sbjct: 773 ----AEEKSERGRQRLSARPPLRE-----QRERQLR------------AEERQQREQRFL 811
Query: 411 PSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEE-----LERRNILKQRND 465
P ++E E R R ++E Q + ++ +++ +R Q E+ ERR +QR D
Sbjct: 812 PEEEEKEQRRRQRREREKELQFLEEEEQLQRRERAQQLQEEEDGLQEDQERRRSQEQRRD 871
Query: 466 QTEQEERREIKQRLTRKLNQRPTVDE-LRDRKILIRFSDYVEVAKAQDYDRRAD-----K 519
Q + + E ++R L +P + E LR + L++ + + ++ RR + +
Sbjct: 872 QKWRWQLEEERKRRRHTLYAKPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYR 931
Query: 520 PWTRLSAADKAAIRKELNEYKSNEME 545
+L ++ +R+E + + E E
Sbjct: 932 EEEQLQQEEEQLLREEREKRRRQERE 957
Score = 35.4 bits (80), Expect = 0.14
Identities = 42/204 (20%), Positives = 89/204 (43%), Gaps = 23/204 (11%)
Query: 304 KHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENK 363
K Q+ Q R + K R + +L + + E+ + +E + LE ++ + E+
Sbjct: 1708 KFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQER---YRKILEEEQLRPEREEQQL 1764
Query: 364 ENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELEDRNIFP 423
+ + +++ L Q+ E + S RK ++E +QE E++ + P
Sbjct: 1765 RRQERDRKFREEEQLRQERE--EQQLRSQESDRKFREE--------EQLRQEREEQQLRP 1814
Query: 424 RRTD------EERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQ 477
++ D EE+ ++ +Q + +R Q A E+ + ++ + QEE ++ +Q
Sbjct: 1815 QQRDGKYRWEEEQLQLEEQEQRLRQERDRQYRAEEQFATQEKSRREEQELWQEEEQKRRQ 1874
Query: 478 RLTRKLNQ----RPTVDELRDRKI 497
RKL + R +E R R++
Sbjct: 1875 ERERKLREEHIRRQQKEEQRHRQV 1898
Score = 34.7 bits (78), Expect = 0.24
Identities = 56/278 (20%), Positives = 118/278 (42%), Gaps = 39/278 (14%)
Query: 289 PPSRVIEELH-RALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDG 347
PP R E RA + R+ F E + ++R R R ++ +E E+ +
Sbjct: 788 PPLREQRERQLRAEERQQREQRFLPEEEEKEQRRRQ--RREREKELQFLEEEEQLQRRER 845
Query: 348 A--LENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAV 405
A L+ + +E +E + + + +D +Q EE RK ++ L
Sbjct: 846 AQQLQEEEDGLQEDQERRRS---QEQRRDQKWRWQLEEE-----------RKRRRHTLYA 891
Query: 406 K--LRNRPSKQEL---EDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNIL 460
K L+ + K++ E+ R E+R+ Q+ + + ++L Q E+L R
Sbjct: 892 KPALQEQLRKEQQLLQEEEEELQREEREKRRRQEQERQYREEEQLQQEE--EQLLREERE 949
Query: 461 KQRNDQTEQEERRE--IKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQ----DYD 514
K+R + E++ R++ ++Q+ + L + P ++R+ R + ++ + Q + +
Sbjct: 950 KRRRQERERQYRKDKKLQQKEEQLLGEEPEKRRRQEREKKYREEEELQQEEEQLLREERE 1009
Query: 515 RRADKPWTR-------LSAADKAAIRKELNEYKSNEME 545
+R + W R L ++ +R+E + + E E
Sbjct: 1010 KRRRQEWERQYRKKDELQQEEEQLLREEREKRRLQERE 1047
Score = 34.3 bits (77), Expect = 0.31
Identities = 44/204 (21%), Positives = 84/204 (41%), Gaps = 41/204 (20%)
Query: 292 RVIEELHRALATKHRQDSFQGRESKGSPKKRL--DVRLSRTSSVERGKEREEAWSFDGAL 349
R ++E L RQ+ + R+ + ++RL + +L R ER +++EE
Sbjct: 269 RELQEEEEQLRKLERQELRRERQEEEQQQQRLRREQQLRRKQEEERREQQEER------- 321
Query: 350 ENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRN 409
+E +E +E Q EE + R+ ++E +LR
Sbjct: 322 -------REQQERRE---------------QQEERREQQL------RREQEERREQQLR- 352
Query: 410 RPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQ 469
+++ E+R R ++E + QQ+ + R Q+ E+ RR +R Q +
Sbjct: 353 ---REQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQQLRR 409
Query: 470 EERREIKQRLTRKLNQRPTVDELR 493
E++ +Q+L R+ R +E R
Sbjct: 410 EQQLRREQQLRREQQLRREQEEER 433
Score = 34.3 bits (77), Expect = 0.31
Identities = 26/95 (27%), Positives = 48/95 (50%), Gaps = 6/95 (6%)
Query: 410 RPSKQELEDRNIFPRRTDEERQEIRQQIEMKL--SKRLSQRPAVEELER----RNILKQR 463
R +Q+L + + EE+Q RQ++E K ++L Q E+L R R IL++
Sbjct: 1694 REEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKILEEE 1753
Query: 464 NDQTEQEERREIKQRLTRKLNQRPTVDELRDRKIL 498
+ E+EE++ +Q RK + + + R+ + L
Sbjct: 1754 QLRPEREEQQLRRQERDRKFREEEQLRQEREEQQL 1788
Score = 33.5 bits (75), Expect = 0.53
Identities = 49/272 (18%), Positives = 114/272 (41%), Gaps = 12/272 (4%)
Query: 284 VHRPLPPSRVIEELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAW 343
+HR + ++E + + Q Q R+ K +++L R R +ER+ +
Sbjct: 1524 LHRQQRQRKFLQEEQQLRRQERGQQRRQDRDRKFREEEQL--RQEREEQQLSRQERDRKF 1581
Query: 344 SFDGALENKRTAAKESEENKENLIINSELKD-----DLLLYQDEEALNDSIISGTLPRKC 398
+ ++ ++ E+++ L + D +DE+ L + ++
Sbjct: 1582 RLEEQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQLLQEREEQQLHRQER 1641
Query: 399 KKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPAVEELE--R 456
++ L + + R ++E + R+ R+ EE Q +++ E +L ++ R EE + R
Sbjct: 1642 DRKFLEEEPQLRRQEREQQLRHDRDRKFREEEQLLQEGEEQQLRRQERDRKFREEEQQLR 1701
Query: 457 RNILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRR 516
R +++ Q EQ+ RR Q L RK + + + +++ L R Y ++ + +
Sbjct: 1702 RQERERKFLQEEQQLRR---QELERKFREEEQLRQETEQEQLRRQERYRKILEEEQLRPE 1758
Query: 517 ADKPWTRLSAADKAAIRKELNEYKSNEMEVHA 548
++ R D+ +E + E ++ +
Sbjct: 1759 REEQQLRRQERDRKFREEEQLRQEREEQQLRS 1790
Score = 32.0 bits (71), Expect = 1.5
Identities = 45/265 (16%), Positives = 108/265 (40%), Gaps = 32/265 (12%)
Query: 295 EELHRALATKHRQDSFQGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRT 354
++L L + +D RE + ++ D +ER +++E + E K+
Sbjct: 1265 QDLQHLLGEQQERD----REQERRRWQQRDRHFPEEEQLEREEQKEAKRRDRKSQEEKQL 1320
Query: 355 AAKESEENKENLIINSELKDDLLLYQDEEAL------------NDSIISGTLPRKCKKEL 402
+E EE + + + +++ L Q+ E + + RK +E
Sbjct: 1321 LREEREEKRRRQETDRKFREEEQLLQEREEQPLRRQERDRKFREEELRHQEQGRKFLEEE 1380
Query: 403 LAVKLRNRPSK------------QELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQRPA 450
++ + R K +E + R R+ EE Q++ +Q + + Q+
Sbjct: 1381 QRLRRQERERKFLKEEQQLRCQEREQQLRQDRDRKFREEEQQLSRQERDRKFREEEQQVR 1440
Query: 451 VEELERRNILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKA 510
+E ER+ + +++ + E+ + +++L ++ ++ + RDRK F + + +
Sbjct: 1441 RQERERKFLEEEQQLRQERHRKFREEEQLLQEREEQQLHRQERDRK----FLEEEQQLRR 1496
Query: 511 QDYDRRADKPWTRLSAADKAAIRKE 535
Q+ DR+ + R ++ + +E
Sbjct: 1497 QERDRKFREQELRSQEPERKFLEEE 1521
Score = 31.6 bits (70), Expect = 2.0
Identities = 49/224 (21%), Positives = 92/224 (41%), Gaps = 16/224 (7%)
Query: 304 KHRQDS-FQGRESKGSPKKRLDVRLSRTSSVE----RGKEREEAWSFDGALENKRTAAKE 358
+ RQD FQ E K K+ +R E R +E +E LE + +
Sbjct: 231 RERQDRVFQEEEEKEWRKRETVLRKEEEKLQEEEPQRQRELQEEEEQLRKLERQELRRER 290
Query: 359 SEENKENLIINSELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSKQELED 418
EE ++ + E L Q+EE + +++ + R + ++E E+
Sbjct: 291 QEEEQQQQRLRRE--QQLRRKQEEERREQQEERREQQERREQQ---EERREQQLRREQEE 345
Query: 419 RNIFPRRTDEERQEIRQQI--EMKLSKRLSQRPAVEELERRNILKQRND-QTEQEERREI 475
R R ++E + QQ+ E + +R Q ++L R L++ + EQ+ RRE
Sbjct: 346 RREQQLRREQEEERREQQLRREQEEERREQQLRREQQLRREQQLRREQQLRREQQLRREQ 405
Query: 476 KQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAKAQDYDRRADK 519
+ R ++L + +LR + L R + + + +RR +
Sbjct: 406 QLRREQQLRRE---QQLRREQQLRREQEEERHEQKHEQERREQR 446
Score = 31.6 bits (70), Expect = 2.0
Identities = 50/251 (19%), Positives = 106/251 (42%), Gaps = 22/251 (8%)
Query: 311 QGRESKGSPKKRLDVRLSRTSSVERGKEREEAWSFDGALENKRTAAKESEENKENLIINS 370
Q R+ + + + +LSR + +E E+ E +R +E ++ ++
Sbjct: 1407 QLRQDRDRKFREEEQQLSRQERDRKFREEEQQVRRQ---ERERKFLEEEQQLRQERHRKF 1463
Query: 371 ELKDDLLLYQDEEALNDSIISGTLPRKCKKELLAVKLRNRPSK---QELEDRNIFPRRTD 427
++ LL ++E+ L+ RK +E ++ + R K QEL + + +
Sbjct: 1464 REEEQLLQEREEQQLHRQ----ERDRKFLEEEQQLRRQERDRKFREQELRSQEPERKFLE 1519
Query: 428 EERQEIRQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQRP 487
EE+Q RQQ + K L + + ER +Q D+ +EE + ++R ++L+++
Sbjct: 1520 EEQQLHRQQRQRKF---LQEEQQLRRQERGQQRRQDRDRKFREEEQLRQEREEQQLSRQE 1576
Query: 488 TVDELRDRKILIRFSDYVEVAKAQDYDRRADKPWTRLSAADKAAIRKELNEYKSNEMEVH 547
RDRK + + + Q+ +R+ + +L + ++ + K E E
Sbjct: 1577 -----RDRKFRLE----EQKVRRQEQERKFMEDEQQLRRQEGQQQLRQERDRKFREDEQL 1627
Query: 548 ASSKHLTRFHR 558
+ + HR
Sbjct: 1628 LQEREEQQLHR 1638
Score = 29.6 bits (65), Expect = 7.6
Identities = 29/106 (27%), Positives = 53/106 (50%), Gaps = 13/106 (12%)
Query: 424 RRTDEERQEIRQQIEMKLSKRLSQRPAVEELERR-NILKQRNDQTEQEE--RREIKQRLT 480
R+ EE Q++R+Q + + Q+ +ELER+ +Q +TEQE+ R+E +++
Sbjct: 1691 RKFREEEQQLRRQERERKFLQEEQQLRRQELERKFREEEQLRQETEQEQLRRQERYRKIL 1750
Query: 481 RKLNQRPTVDEL------RDRKI----LIRFSDYVEVAKAQDYDRR 516
+ RP +E RDRK +R + ++Q+ DR+
Sbjct: 1751 EEEQLRPEREEQQLRRQERDRKFREEEQLRQEREEQQLRSQESDRK 1796
>gi|22035606 mitogen-activated protein kinase kinase kinase kinase 4
isoform 3 [Homo sapiens]
Length = 1212
Score = 45.1 bits (105), Expect = 2e-04
Identities = 38/187 (20%), Positives = 84/187 (44%), Gaps = 11/187 (5%)
Query: 334 ERGKEREEAWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGT 393
++ ER+ ++ R E +E + + E ++++ ++E SI++
Sbjct: 291 DQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEV---PEQEGEPSSIVNVP 347
Query: 394 LPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQ----RP 449
+++ L ++ N+ + L + + + E++E ++Q+ + KR+ Q R
Sbjct: 348 GESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRR 407
Query: 450 AVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAK 509
+EE +RR +R + EQ R + ++R +L +R +E R R + V +
Sbjct: 408 RLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRR----AEEEKRRVER 463
Query: 510 AQDYDRR 516
Q+Y RR
Sbjct: 464 EQEYIRR 470
Score = 37.7 bits (86), Expect = 0.028
Identities = 44/165 (26%), Positives = 77/165 (46%), Gaps = 23/165 (13%)
Query: 334 ERGKEREEAWSFDGALENKRTAAKESEENKENLIIN----SELKDDLLLYQDE-----EA 384
+RG++ E + + G+ E + ++ E + + I+N S L+ D L Q E EA
Sbjct: 312 KRGEKDETEYEYSGSEEEEEEVPEQ--EGEPSSIVNVPGESTLRRDFLRLQQENKERSEA 369
Query: 385 LN-DSIISGTLPRK---CKKELLAVKLRN-------RPSKQELEDRNIFPRRTDEERQEI 433
L ++ R+ K++LLA + + R +E + R RR E Q
Sbjct: 370 LRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRR 429
Query: 434 RQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEE-RREIKQ 477
R+Q E + + L +R EE RR ++R + EQE RR++++
Sbjct: 430 REQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEE 474
>gi|22035602 mitogen-activated protein kinase kinase kinase kinase 4
isoform 1 [Homo sapiens]
Length = 1166
Score = 45.1 bits (105), Expect = 2e-04
Identities = 38/187 (20%), Positives = 84/187 (44%), Gaps = 11/187 (5%)
Query: 334 ERGKEREEAWSFDGALENKRTAAKESEENKENLIINSELKDDLLLYQDEEALNDSIISGT 393
++ ER+ ++ R E +E + + E ++++ ++E SI++
Sbjct: 291 DQPNERQVRIQLKDHIDRTRKKRGEKDETEYEYSGSEEEEEEV---PEQEGEPSSIVNVP 347
Query: 394 LPRKCKKELLAVKLRNRPSKQELEDRNIFPRRTDEERQEIRQQIEMKLSKRLSQ----RP 449
+++ L ++ N+ + L + + + E++E ++Q+ + KR+ Q R
Sbjct: 348 GESTLRRDFLRLQQENKERSEALRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRR 407
Query: 450 AVEELERRNILKQRNDQTEQEERREIKQRLTRKLNQRPTVDELRDRKILIRFSDYVEVAK 509
+EE +RR +R + EQ R + ++R +L +R +E R R + V +
Sbjct: 408 RLEEQQRREREARRQQEREQRRREQEEKRRLEELERRRKEEEERRR----AEEEKRRVER 463
Query: 510 AQDYDRR 516
Q+Y RR
Sbjct: 464 EQEYIRR 470
Score = 37.7 bits (86), Expect = 0.028
Identities = 44/165 (26%), Positives = 77/165 (46%), Gaps = 23/165 (13%)
Query: 334 ERGKEREEAWSFDGALENKRTAAKESEENKENLIIN----SELKDDLLLYQDE-----EA 384
+RG++ E + + G+ E + ++ E + + I+N S L+ D L Q E EA
Sbjct: 312 KRGEKDETEYEYSGSEEEEEEVPEQ--EGEPSSIVNVPGESTLRRDFLRLQQENKERSEA 369
Query: 385 LN-DSIISGTLPRK---CKKELLAVKLRN-------RPSKQELEDRNIFPRRTDEERQEI 433
L ++ R+ K++LLA + + R +E + R RR E Q
Sbjct: 370 LRRQQLLQEQQLREQEEYKRQLLAERQKRIEQQKEQRRRLEEQQRREREARRQQEREQRR 429
Query: 434 RQQIEMKLSKRLSQRPAVEELERRNILKQRNDQTEQEE-RREIKQ 477
R+Q E + + L +R EE RR ++R + EQE RR++++
Sbjct: 430 REQEEKRRLEELERRRKEEEERRRAEEEKRRVEREQEYIRRQLEE 474
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.308 0.125 0.345
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,934,139
Number of Sequences: 37866
Number of extensions: 1177236
Number of successful extensions: 10598
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 93
Number of HSP's successfully gapped in prelim test: 939
Number of HSP's that attempted gapping in prelim test: 7763
Number of HSP's gapped (non-prelim): 2892
length of query: 559
length of database: 18,247,518
effective HSP length: 107
effective length of query: 452
effective length of database: 14,195,856
effective search space: 6416526912
effective search space used: 6416526912
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.7 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.