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Search of human proteins with 17136078
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|17136078 VGF nerve growth factor inducible precursor [Homo
sapiens]
(615 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|17136078 VGF nerve growth factor inducible precursor [Homo sa... 1234 0.0
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 75 2e-13
gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens] 70 6e-12
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 67 5e-11
gi|55741677 SET domain containing 1A [Homo sapiens] 65 2e-10
gi|155030232 proline, glutamic acid and leucine rich protein 1 [... 64 4e-10
gi|102467242 inner centromere protein antigens 135/155kDa isofor... 64 5e-10
gi|102467235 inner centromere protein antigens 135/155kDa isofor... 63 7e-10
gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1 ... 62 1e-09
gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2 ... 62 1e-09
gi|78042577 MAP7 domain containing 1 [Homo sapiens] 62 2e-09
gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo sap... 60 5e-09
gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo sap... 60 5e-09
gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo sap... 60 5e-09
gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo sapi... 60 5e-09
gi|7662302 TBK1 binding protein 1 [Homo sapiens] 59 2e-08
gi|88196790 coiled-coil domain containing 88 [Homo sapiens] 58 2e-08
gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens] 58 2e-08
gi|41322923 plectin 1 isoform 11 [Homo sapiens] 57 7e-08
gi|41322914 plectin 1 isoform 10 [Homo sapiens] 57 7e-08
gi|41322919 plectin 1 isoform 8 [Homo sapiens] 57 7e-08
gi|41322910 plectin 1 isoform 7 [Homo sapiens] 57 7e-08
gi|41322916 plectin 1 isoform 6 [Homo sapiens] 57 7e-08
gi|41322908 plectin 1 isoform 3 [Homo sapiens] 57 7e-08
gi|41322912 plectin 1 isoform 2 [Homo sapiens] 57 7e-08
gi|47607492 plectin 1 isoform 1 [Homo sapiens] 57 7e-08
gi|4505101 microtubule-associated protein 7 [Homo sapiens] 57 7e-08
gi|56549694 enabled homolog isoform a [Homo sapiens] 55 1e-07
gi|39930375 enabled homolog isoform b [Homo sapiens] 55 1e-07
gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens] 55 1e-07
>gi|17136078 VGF nerve growth factor inducible precursor [Homo
sapiens]
Length = 615
Score = 1234 bits (3193), Expect = 0.0
Identities = 615/615 (100%), Positives = 615/615 (100%)
Query: 1 MKALRLSASALFCLLLINGLGAAPPGRPEAQPPPLSSEHKEPVAGDAVPGPKDGSAPEVR 60
MKALRLSASALFCLLLINGLGAAPPGRPEAQPPPLSSEHKEPVAGDAVPGPKDGSAPEVR
Sbjct: 1 MKALRLSASALFCLLLINGLGAAPPGRPEAQPPPLSSEHKEPVAGDAVPGPKDGSAPEVR 60
Query: 61 GARNSEPQDEGELFQGVDPRALAAVLLQALDRPASPPAPSGSQQGPEEEAAEALLTETVR 120
GARNSEPQDEGELFQGVDPRALAAVLLQALDRPASPPAPSGSQQGPEEEAAEALLTETVR
Sbjct: 61 GARNSEPQDEGELFQGVDPRALAAVLLQALDRPASPPAPSGSQQGPEEEAAEALLTETVR 120
Query: 121 SQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQET 180
SQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQET
Sbjct: 121 SQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQET 180
Query: 181 AAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSGP 240
AAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSGP
Sbjct: 181 AAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSGP 240
Query: 241 LPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQG 300
LPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQG
Sbjct: 241 LPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQG 300
Query: 301 LAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEERES 360
LAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEERES
Sbjct: 301 LAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEERES 360
Query: 361 AREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRS 420
AREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRS
Sbjct: 361 AREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRS 420
Query: 421 QEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKR 480
QEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKR
Sbjct: 421 QEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKR 480
Query: 481 KRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVLPPWDREEDEVYPP 540
KRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVLPPWDREEDEVYPP
Sbjct: 481 KRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVLPPWDREEDEVYPP 540
Query: 541 GPYHPFPNYIRPRTLQPPSALRRRHYHHALPPSRHYPGREAQARRAQEEAEAEERRLQEQ 600
GPYHPFPNYIRPRTLQPPSALRRRHYHHALPPSRHYPGREAQARRAQEEAEAEERRLQEQ
Sbjct: 541 GPYHPFPNYIRPRTLQPPSALRRRHYHHALPPSRHYPGREAQARRAQEEAEAEERRLQEQ 600
Query: 601 EELENYIEHVLLRRP 615
EELENYIEHVLLRRP
Sbjct: 601 EELENYIEHVLLRRP 615
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 74.7 bits (182), Expect = 2e-13
Identities = 103/524 (19%), Positives = 191/524 (36%), Gaps = 47/524 (8%)
Query: 22 AAPPGRPEAQPPPLSSEHKEPVAGDAVPGPKDGSAPEVRGARNSEPQDEGELFQGVDPRA 81
A P + EA+ P +E K P + + S PE + E + E+ P
Sbjct: 530 AKSPEKEEAKSP---AEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEV---KSPEK 583
Query: 82 LAAVLLQALDRPASPPAPSGSQQGPEEEA-AEALLTETVRSQTHSLPAPESPEPAAPPRP 140
+ + PA +P ++ +EEA + A V+ + S +SPE A P
Sbjct: 584 AKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTK 643
Query: 141 QTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESP 200
+ ++ +A P +E + S ++ + AE ++ + V E+
Sbjct: 644 EEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAK 703
Query: 201 GPERVWRASWGEFQARVPERAPLP----PPAPSQFQARMPDSGPLPETHKFGEGVSSPKT 256
PE+ S + +A+ PE+A P P + ++ + + PE K E +
Sbjct: 704 SPEKA--KSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAKTLDV 761
Query: 257 HLGEALAPLSKAYQGVAAPFP-KARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATR 315
EA P + + A FP KA+ P + E + L++ E + E +
Sbjct: 762 KSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVK 821
Query: 316 QAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEERESAREEEEAEQERRGGE 375
+EE+ QE + + EEE E
Sbjct: 822 SPVKEEEKP---------------------------QEVKVKEPPKKAEEEKAPATPKTE 854
Query: 376 ERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRK---EA 432
E+ + EEA + EA + E ++ A+ +E EA E+ +++ P ++ +
Sbjct: 855 EKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKV 914
Query: 433 EGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKRKRKKNAPPEPVP 492
E E+ +E E + D+ + +K PA+ + E+ + K ++ K +P
Sbjct: 915 EVKEDAKPKEKTEVAKKEPDDAKAKEPSK---PAEKKEAAPEKKDTKEEKAKKPEEKPKT 971
Query: 493 PPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVLPPWDREEDE 536
+A + P A + D + PP ED+
Sbjct: 972 EAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPPEKATEDK 1015
Score = 59.7 bits (143), Expect = 8e-09
Identities = 96/464 (20%), Positives = 181/464 (39%), Gaps = 33/464 (7%)
Query: 95 SPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPE---------SPEPAAPPRPQTPEN 145
SPPA + PE+EA + E P E SPE A P + ++
Sbjct: 503 SPPAEEAAS--PEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKS 560
Query: 146 GPEASDP-SEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPER 204
PEA P EE ++ A + + SP+ +++ + AE ++ + V E+ P
Sbjct: 561 PPEAKSPEKEEAKSPAEVKSPEKAKSPA---KEEAKSPAEAKSPEKAKSPVKEEAKSPAE 617
Query: 205 VWRASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAP 264
E ++ ++P +P++ +A+ P+ PE + + EA +P
Sbjct: 618 AKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSP 677
Query: 265 LSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERL 324
KA V A +A+ PE A E + ++ + V+ + E + +E +
Sbjct: 678 -EKAKSPVKA---EAKSPEKAKSPVKEEA-KSPEKAKSPVKEEAKSPEKAKSPVKEEAKT 732
Query: 325 ADLASDLLLQYLLQGGARQRGLGGRGLQEAAEERESAREEE---EAEQERRGGEERVGEE 381
+ A + + + + L + E ++ +EE A++ + V EE
Sbjct: 733 PEKAKSPVKEEAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEE 792
Query: 382 DEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQ---EETPGHRRKE-AEGTEE 437
+ +A++ +E +A + + EE E+K + +E P +E A T +
Sbjct: 793 VKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPK 852
Query: 438 GGEEEDDEEMDPQTIDSLIELSTKLHLPADD--VVSIIEEVEEKRKRKKNAPPEPVPPPR 495
E++D ++ + ++ + PA + S +E +E+ + KK P P +
Sbjct: 853 TEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVP----TPEK 908
Query: 496 AAPAPTHVRSPQPPPPAPAPARDELPDWNEVLPPWDREEDEVYP 539
APA V+ P A+ E D P E+ E P
Sbjct: 909 EAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEKKEAAP 952
Score = 55.5 bits (132), Expect = 1e-07
Identities = 51/190 (26%), Positives = 79/190 (41%), Gaps = 28/190 (14%)
Query: 357 ERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAE 416
E+E+ EE+ E E + EE EE++EA E E + EE EEE+ E G E
Sbjct: 451 EKETVIVEEQTE-ETQVTEEVTEEEEKEAKEEEGKEEEG----------GEEEEAEGGEE 499
Query: 417 DKRS---------QEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPAD 467
+ +S ++E ++EA+ E E +E P + S K PA
Sbjct: 500 ETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKS----PEKAKSPAK 555
Query: 468 DVVSIIEEVEEKRKRKKNAPPEPVPPPRA-APAPTHVRSP---QPPPPAPAPARDELPDW 523
+ E + K + +P E P +A +PA +SP + P A +P ++E
Sbjct: 556 EEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSP 615
Query: 524 NEVLPPWDRE 533
E P E
Sbjct: 616 AEAKSPVKEE 625
Score = 46.2 bits (108), Expect = 9e-05
Identities = 51/218 (23%), Positives = 87/218 (39%), Gaps = 17/218 (7%)
Query: 304 VEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEERESARE 363
VE + + T + +EE+ A + GG + GG EE +S
Sbjct: 457 VEEQTEETQVTEEVTEEEEKEAKEEEGKEEE----GGEEEEAEGGE------EETKSPPA 506
Query: 364 EEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEE 423
EE A E+ E + ++E + AEA++ E E A+ A + + E+ E+ +S E
Sbjct: 507 EEAASPEK---EAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPPE 563
Query: 424 TPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELST--KLHLPADDVVSIIEEVEEKRK 481
++EA+ E E + + S E + K P + E + K
Sbjct: 564 AKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSPAEAKSPVK 623
Query: 482 RKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDE 519
+ +P E V P A +PT + P A +P ++E
Sbjct: 624 EEAKSPAE-VKSPEKAKSPTK-EEAKSPEKAKSPEKEE 659
Score = 45.1 bits (105), Expect = 2e-04
Identities = 86/430 (20%), Positives = 159/430 (36%), Gaps = 45/430 (10%)
Query: 22 AAPPGRPEAQPPPLSSEHKEPVAGDA-----VPGPKDGSAPEVRGARNSEPQDEGELFQG 76
A P + EA+ P +E K PV +A V P+ +P A++ E E +
Sbjct: 604 AKSPVKEEAKSP---AEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEA 660
Query: 77 VDPRALAAVLLQALDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPE---SPE 133
P + + P +P ++ E+A + E + P E SPE
Sbjct: 661 KSPEKAKSPVKAEAKSPEKAKSPVKAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPE 720
Query: 134 PAAPPRPQTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQETAAAETET-RTHTL 192
A P + + +A P +E EA SP AK ++ + ++ T
Sbjct: 721 KAKSPVKEEAKTPEKAKSPVKE-EAK----------SPEKAKSPEKAKTLDVKSPEAKTP 769
Query: 193 TRVNLESPG---PERVWRASWGEFQARVPERAPLPPPAPS---QFQARMPDSGPLPETHK 246
+ SP PE+ E ++ ++PL A + + + P+ E K
Sbjct: 770 AKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEK 829
Query: 247 FGE-GVSSPKTHLGEALAPL---------SKAYQGVAAPFPKARRPESALLGGSEAGERL 296
E V P E AP SK + PK + E + E
Sbjct: 830 PQEVKVKEPPKKAEEEKAPATPKTEEKKDSKKEEAPKKEAPKPKVEEKKEPAVEKPKESK 889
Query: 297 LQQGLAQVEAGRRQAEATRQAAAQEERLADLA----SDLLLQYLLQGGARQRGLGGRGLQ 352
++ + E ++ ++A A+ E D +++ + A++ +
Sbjct: 890 VEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPKEKTEVAKKEPDDAKAKEPSKPAEK-K 948
Query: 353 EAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEE-EDG 411
EAA E++ +EE+ + E + E +ED++ E +AE+A +++ ++ +
Sbjct: 949 EAAPEKKDTKEEKAKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDSKPP 1008
Query: 412 EAGAEDKRSQ 421
E EDK ++
Sbjct: 1009 EKATEDKAAK 1018
Score = 43.5 bits (101), Expect = 6e-04
Identities = 42/162 (25%), Positives = 67/162 (41%), Gaps = 17/162 (10%)
Query: 378 VGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEE 437
V + ++E E + EE + + EEE+ EA E+ + +E G +EAEG EE
Sbjct: 447 VEKSEKETVIVEEQTEETQVTEE----VTEEEEKEAKEEEGKEEE---GGEEEEAEGGEE 499
Query: 438 GGEEEDDEEMDPQTIDSLIELSTKLHLPAD------DVVSIIEEVEEKRKRKKNAPPEPV 491
+ EE ++ + + PA+ + EV+ K K A E
Sbjct: 500 ETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAK 559
Query: 492 PPPRA-APAPTHVRSP---QPPPPAPAPARDELPDWNEVLPP 529
PP A +P +SP + P A +PA++E E P
Sbjct: 560 SPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSP 601
>gi|117414137 retinitis pigmentosa 1-like 1 [Homo sapiens]
Length = 2400
Score = 70.1 bits (170), Expect = 6e-12
Identities = 140/607 (23%), Positives = 213/607 (35%), Gaps = 91/607 (14%)
Query: 23 APPGRPEAQPP------PLSSEHKEPVAGDAVPGPKDGSAPEVRGARNSEPQD--EGELF 74
AP EAQP P + + G+A P +D APE G E +D E
Sbjct: 1837 APEAEGEAQPESEGVEAPEAEGDAQEAEGEAQPESEDVEAPEAEGEAQPESEDVETPEAE 1896
Query: 75 QGVDPRALAAVLLQALDRPASPPAPS------GSQQGPEEEAAEALLTETVRSQTHSLPA 128
V P + A +A ++ A P S + PE E AEA E +
Sbjct: 1897 WEVQPESEGAEAPEA-EKEAQPETESVEALETEGEDEPESEGAEAQEAEEAAQEAEGQTQ 1955
Query: 129 PESPEPAAPPRPQTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETR 188
PES ++ E EA SE++EAL + + ET AE E +
Sbjct: 1956 PESEVI------ESQEAEEEAQPESEDVEAL---------------EVEVETQEAEGEAQ 1994
Query: 189 THTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFG 248
+ ++E+P E GE Q E P +Q ++ ++ + +
Sbjct: 1995 PES---EDVEAPEAE-------GEMQEAEEEAQPESDGVEAQPKSEGEEAQEVEGETQKT 2044
Query: 249 EGVSSPKTHLGEALAPLSKAYQ--GVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEA 306
EG + P++ EA +A + G PES + EA +G AQ E+
Sbjct: 2045 EGDAQPESDGVEAPEAEEEAQEAEGEVQEAEGEAHPESEDVDAQEA------EGEAQPES 2098
Query: 307 GRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEERESAREEEE 366
+A A + E + ++ Q +G G Q +E E+ E E
Sbjct: 2099 EGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPEAEGEA--QPESEGVEAQDAEGE 2156
Query: 367 AEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPG 426
A+ E G E + EE+ + EA EAE Q E + E A+ + E P
Sbjct: 2157 AQPESEGIEAQEAEEEAQPELEGVEAPEAEGEAQPESEGIEAPEAEGEAQPELEGVEAP- 2215
Query: 427 HRRKEAEGTEEGGEEEDDE-EMDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKRKRKKN 485
+EA+ EG E + E E P++ E T+ VS+ + E+ +
Sbjct: 2216 EAEEEAQPEPEGVETPEAEGEAQPES-----EGETQGEKKGSPQVSLGDGQSEEASESSS 2270
Query: 486 APPE--PVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVLPPWDREEDEVYPPGPY 543
PE P PPP H Q P P+ W W ++ + + G
Sbjct: 2271 PVPEDRPTPPPSPGGDTPH----QRPGSQTGPSSSRASSWGNC---WQKDSENDHVLG-- 2321
Query: 544 HPFPNYIRPRTLQPPSALRRRHYHHALPPSRHYPGREAQAR-------RAQEEAEAEERR 596
+ P A H +R YP + R E+ +E
Sbjct: 2322 ----------DTRSPDAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQGASEGYD 2371
Query: 597 LQEQEEL 603
LQE + L
Sbjct: 2372 LQEDQAL 2378
Score = 59.7 bits (143), Expect = 8e-09
Identities = 108/530 (20%), Positives = 181/530 (34%), Gaps = 92/530 (17%)
Query: 45 GDAVPGPKDGSAPEVRGARNSEPQDEGELFQGVDPRALAAVLLQALDRPASPPAPSGSQQ 104
GDA+ ++G + SE + + +G+ R + A +G Q
Sbjct: 1765 GDAMAQEREGKTHNSETSAGSELGEAEQEGEGISERGETGGQGSGHEDNLQGEAAAGGDQ 1824
Query: 105 GP-EEEAAEALLTETVRSQTHSLPAPESPEPAAPPRPQTPE-NGPEASDPSEELEALASL 162
P + + AE + E+PE +P++ PEA ++E E A
Sbjct: 1825 DPGQSDGAEGI---------------EAPEAEGEAQPESEGVEAPEAEGDAQEAEGEAQ- 1868
Query: 163 LQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAP 222
E D A+ + + + + ET PE W A PE
Sbjct: 1869 -PESEDVEAPEAEGEAQPESEDVET--------------PEAEWEVQPESEGAEAPEAEK 1913
Query: 223 LPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRP 282
P +A ET EG P++ EA A + +P
Sbjct: 1914 EAQPETESVEAL--------ET----EGEDEPESEGAEAQEAEEAAQEAEGQT-----QP 1956
Query: 283 ESALLGGSEAGERLLQQG----LAQVEAGRRQAEATRQAAAQEERLADLASDLL-----L 333
ES ++ EA E + +VE ++AE Q +++ + ++
Sbjct: 1957 ESEVIESQEAEEEAQPESEDVEALEVEVETQEAEGEAQPESEDVEAPEAEGEMQEAEEEA 2016
Query: 334 QYLLQGGARQRGLGGRGLQEAAEER--------------ESAREEEEAEQERRGGEERVG 379
Q G Q G QE E E+ EEEA++ +E G
Sbjct: 2017 QPESDGVEAQPKSEGEEAQEVEGETQKTEGDAQPESDGVEAPEAEEEAQEAEGEVQEAEG 2076
Query: 380 EEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTE--- 436
E E+ + +A+ E E ++ + A E +GEA + ET G + E+EG E
Sbjct: 2077 EAHPESEDVDAQEAEGEAQPESEGVEAPEAEGEAQKAEGIEAPETEGEAQPESEGIEAPE 2136
Query: 437 -EGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKRKRKKNAPPEPVPPPR 495
EG + + E ++ Q + + P + + +E EE+ + + P
Sbjct: 2137 AEGEAQPESEGVEAQDAEGEAQ-------PESEGIE-AQEAEEEAQPELEGVEAPEAEGE 2188
Query: 496 AAPAPTHVRSPQPPPPAPAPARDELPDWNEVLPPWDREEDEVYPPGPYHP 545
A P + +P+ A P+ V P EE + P G P
Sbjct: 2189 AQPESEGIEAPEAEGEAQ-------PELEGVEAPEAEEEAQPEPEGVETP 2231
Score = 47.4 bits (111), Expect = 4e-05
Identities = 110/485 (22%), Positives = 164/485 (33%), Gaps = 101/485 (20%)
Query: 21 GAAPPGR--PEAQPPPLSSEHKEPVAGDAVPGPKDGSAPEVRGARNSEPQDEGELFQGVD 78
GAA G PE P +H G+ P + G +P+ EG L D
Sbjct: 981 GAAGGGLRGPEVDP---GDDHSLEGLGE----PAQAGQQSLEGDPGQDPEPEGALLGSSD 1033
Query: 79 PRALAAVLLQALDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAP- 137
Q+ + AP G + P E A+ R +LP S
Sbjct: 1034 TGP------QSGEGVPQGAAPEGVSEAPAEAGADREAPAGCRVSLRALPGRVSASTQIMR 1087
Query: 138 ----PRPQTPENGPEASDP-----SEELEALASLLQELRDF-----SPSSAKRQQETAAA 183
+ P + PE S P S AL + L L+ F SP+S R +++
Sbjct: 1088 ALMGSKQGRPSSVPEVSRPMARRLSCSAGALITCLASLQLFEEDLGSPASKVRFKDSP-- 1145
Query: 184 ETETRTHTLTRVNLES-PGPE--------RVWRASWGEFQARVPERAPLPPPAPSQFQAR 234
R L ++ + PG + +W +W +
Sbjct: 1146 ----RYQELLSISKDLWPGCDVGEDQLDSGLWELTWSQ---------------------A 1180
Query: 235 MPDSGPLPETHKF------GEGVSSPKTHLGEALAPLSK----AYQGVAAPFPKA-RRPE 283
+PD G T F G +SS GE+ P + QG P + +RP+
Sbjct: 1181 LPDLGSHAMTENFTPTSSSGVDISSGSGGSGESSVPCAMDGTLVTQGTELPLKTSNQRPD 1240
Query: 284 SALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLL-------LQYL 336
S E Q R A AT + A+ + AS L +Q
Sbjct: 1241 SRTYESPGDLENQQQCCFPTFLNARACACATNEDEAERDSEEQRASSNLEQLAENTVQEE 1300
Query: 337 LQGGARQRGLGGRGLQEAAEERESAREEEEAEQERRGGEERV-----GEEDEEAAEAEAE 391
+Q + G G GLQE A + E + EE ++E EE G+++EEA E E
Sbjct: 1301 VQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIE 1360
Query: 392 AEEAERARQNALLFAEEEDGEAGA------EDKRSQEETP------GHRRKEAEGTEEGG 439
E ++ + E ++G G E+ +E P G EA + G
Sbjct: 1361 ETGGEGLQEEGVQLEEVKEGPEGGLQGEALEEGLKEEGLPEEGSVHGQELSEASSPDGKG 1420
Query: 440 EEEDD 444
+EDD
Sbjct: 1421 SQEDD 1425
Score = 42.7 bits (99), Expect = 0.001
Identities = 45/163 (27%), Positives = 61/163 (37%), Gaps = 28/163 (17%)
Query: 283 ESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGAR 342
E+ L ++ E L ++G+ E + E ++ AQ E + +
Sbjct: 1318 EAVQLEETKTEEGLQEEGVQLEETKETEGEGQQEEEAQLEEIEET--------------- 1362
Query: 343 QRGLGGRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNA 402
GG GLQE + E +E E GG + GE EE + E EE Q
Sbjct: 1363 ----GGEGLQEEGVQLEEVKEGPE------GGLQ--GEALEEGLKEEGLPEEGSVHGQE- 1409
Query: 403 LLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDE 445
L A DG+ ED QEE G AE G EE E
Sbjct: 1410 LSEASSPDGKGSQEDDPVQEEEAGRASASAEPCPAEGTEEPTE 1452
Score = 38.1 bits (87), Expect = 0.024
Identities = 48/175 (27%), Positives = 60/175 (34%), Gaps = 42/175 (24%)
Query: 23 APPGRPEAQPPPLSSEHKEPVAGDAVPGPKDGSAPEVRGARNSEPQDEGELFQGVDPRAL 82
AP EAQP P E E G+A P S E +G + PQ L G A
Sbjct: 2214 APEAEEEAQPEPEGVETPE-AEGEAQPE----SEGETQGEKKGSPQVS--LGDGQSEEAS 2266
Query: 83 AAVLLQALDRPASPPAPSG--------SQQGPEEEAAEA-------------LLTETVRS 121
+ DRP PP+P G SQ GP A + +L +T
Sbjct: 2267 ESSSPVPEDRPTPPPSPGGDTPHQRPGSQTGPSSSRASSWGNCWQKDSENDHVLGDTRSP 2326
Query: 122 QTHSLPAPESPEPA--------------APPRPQTPENGPEASDPSEELEALASL 162
S P + A AP +TPE G +E +AL SL
Sbjct: 2327 DAKSTGTPHAERKATRMYPESSTSEQEEAPLGSRTPEQGASEGYDLQEDQALGSL 2381
Score = 34.7 bits (78), Expect = 0.27
Identities = 28/95 (29%), Positives = 43/95 (45%), Gaps = 2/95 (2%)
Query: 352 QEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDG 411
+++ E+R S+ E+ AE + EE EE +E E E EEA + + +E+G
Sbjct: 1278 RDSEEQRASSNLEQLAENTVQ--EEVQLEETKEGTEGEGLQEEAVQLEETKTEEGLQEEG 1335
Query: 412 EAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEE 446
E K ++ E + E EE G E EE
Sbjct: 1336 VQLEETKETEGEGQQEEEAQLEEIEETGGEGLQEE 1370
Score = 31.6 bits (70), Expect = 2.2
Identities = 55/235 (23%), Positives = 82/235 (34%), Gaps = 34/235 (14%)
Query: 97 PAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPE--ASDPSE 154
P P + P+ ++ T + T P E P P TP GP AS S
Sbjct: 854 PTPPRGRPCPQRRSSSCGSTGSSHQSTARGPGGSPQEGTRQPGP-TPSPGPNSGASRRSS 912
Query: 155 ELEALASL-LQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEF 213
+ S L E + + QE A+ + + +L PE V R E+
Sbjct: 913 ASQGAGSRGLSEEKTLRSGGGPQGQEEASGVSPS--------SLPRSSPEAVVR----EW 960
Query: 214 QARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALA------PLSK 267
+PE P + D T G G+ P+ G+ + P
Sbjct: 961 LDNIPEE-------PILMTYELADE----TTGAAGGGLRGPEVDPGDDHSLEGLGEPAQA 1009
Query: 268 AYQGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEE 322
Q + + PE ALLG S+ G + +G+ Q A +EA +A A E
Sbjct: 1010 GQQSLEGDPGQDPEPEGALLGSSDTGPQ-SGEGVPQGAAPEGVSEAPAEAGADRE 1063
Score = 30.8 bits (68), Expect = 3.8
Identities = 14/38 (36%), Positives = 22/38 (57%)
Query: 121 SQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEA 158
S S PE EP + P+TPE+G +++ PS ++ A
Sbjct: 454 SPASSTGLPEGSEPESSCCPRTPEDGVDSASPSAQIGA 491
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 67.0 bits (162), Expect = 5e-11
Identities = 52/160 (32%), Positives = 69/160 (43%), Gaps = 9/160 (5%)
Query: 289 GSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRG--L 346
G E GE +G + E G R+ E + E D + +G ++ G +
Sbjct: 755 GKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEV 814
Query: 347 GGRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFA 406
G ++E ERE EE E E+E GEE GE +EE E + E EE E
Sbjct: 815 EGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGE-EEGEEGE------G 867
Query: 407 EEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEE 446
EEE E E + + E G E EG EE GE E +EE
Sbjct: 868 EEEGEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEE 907
Score = 65.9 bits (159), Expect = 1e-10
Identities = 54/165 (32%), Positives = 72/165 (43%), Gaps = 20/165 (12%)
Query: 291 EAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRG 350
E GER ++ + E G + + Q +EE + ++GG + G G R
Sbjct: 771 EEGERKKEERAGKEEKGEEEGD---QGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGERE 827
Query: 351 LQEA---AEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAE 407
+E EE E EEEE E E GE + GEE+ E E E E EE E E
Sbjct: 828 EEEEEGEGEEEEGEGEEEEGEGEEEEGEGK-GEEEGEEGEGEEEGEEGEGE-------GE 879
Query: 408 EEDGEAGAEDKRSQE------ETPGHRRKEAEGTEEGGEEEDDEE 446
EE+GE E++ E E G E EG EE GE + +EE
Sbjct: 880 EEEGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEE 924
Score = 62.8 bits (151), Expect = 9e-10
Identities = 56/177 (31%), Positives = 72/177 (40%), Gaps = 27/177 (15%)
Query: 288 GGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLG 347
G E GE ++G + E G + E + EE + + G + G G
Sbjct: 835 GEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGE---------GEEEEGEG 885
Query: 348 -------GRGLQEAAE---ERESAREEEEAEQERRG---GEERVGEEDEEAAEAEAEAEE 394
G G +E E E E E EE E E +G GEE GE +EE E E E E
Sbjct: 886 EGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGE 945
Query: 395 AERARQNALLFAEEEDGEAGAEDKRSQEETPG-----HRRKEAEGTEEGGEEEDDEE 446
E + EEE+GE E++ E G E EG EE GEEE +EE
Sbjct: 946 GEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEE 1002
Score = 60.8 bits (146), Expect = 3e-09
Identities = 48/155 (30%), Positives = 76/155 (49%), Gaps = 10/155 (6%)
Query: 291 EAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRG 350
E GE+ +G ++E R E ++ A +EE + + QG ++R +
Sbjct: 675 EKGEK--DKGRGEME---RPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERN---QE 726
Query: 351 LQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEED 410
++E EE EEEE ++E +E G+E+ E E E E E+ E R+ +EE
Sbjct: 727 MEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEK 786
Query: 411 G-EAGAEDKRSQEETPGHRRKEAEGTE-EGGEEED 443
G E G + + +EET G ++ EG E EGGE E+
Sbjct: 787 GEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEE 821
Score = 58.5 bits (140), Expect = 2e-08
Identities = 53/164 (32%), Positives = 67/164 (40%), Gaps = 12/164 (7%)
Query: 289 GSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQ-RGLG 347
G E GE G + E G + E + +EE + + +G + G G
Sbjct: 887 GEEEGE-----GEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEG 941
Query: 348 GRGLQEAAEER---ESAREEEEAEQERRG---GEERVGEEDEEAAEAEAEAEEAERARQN 401
G E EE E EE E E E G GEE GE +EE E E E EE E +
Sbjct: 942 EDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEE 1001
Query: 402 ALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDE 445
EE +GE E++ E E EG EE GEEE +E
Sbjct: 1002 EGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEE 1045
Score = 58.2 bits (139), Expect = 2e-08
Identities = 52/163 (31%), Positives = 69/163 (42%), Gaps = 15/163 (9%)
Query: 289 GSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGG 348
G E GE +G + E G + E + +EE + +G + G
Sbjct: 867 GEEEGEE--GEGEGEEEEGEGEGEEEGEGEGEEEEGEGEGEEEG-----EGEGEEEEGEG 919
Query: 349 RGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAE------AEEAERARQNA 402
+G +E EE E EEEE E E GE GEE+E E E E EE E +
Sbjct: 920 KG-EEEGEEGEGEGEEEEGEGEGEDGEGE-GEEEEGEWEGEEEEGEGEGEEEGEGEGEEG 977
Query: 403 LLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDE 445
EEE+GE E++ +EE E EG EG EEE+ E
Sbjct: 978 EGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGE 1020
Score = 57.0 bits (136), Expect = 5e-08
Identities = 41/115 (35%), Positives = 54/115 (46%), Gaps = 11/115 (9%)
Query: 340 GARQRGLGGRGLQEAAEERESAREEEEAEQERRGGEERVGE-EDEEAAEAEAEAEEAERA 398
G + G G +E E E EEE E+E G EE GE E+EE E E E E E
Sbjct: 972 GEGEEGEGEGEEEEGEGEGEEEEGEEEGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGE 1031
Query: 399 RQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGE-----EEDDEEMD 448
+ EEE+GE E++ + E +RR E EE G+ EE++E D
Sbjct: 1032 GEG-----EEEEGEEEGEEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQD 1081
Score = 55.8 bits (133), Expect = 1e-07
Identities = 34/98 (34%), Positives = 53/98 (54%), Gaps = 6/98 (6%)
Query: 350 GLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEE 409
G ++ +ERE ++E ++ GGEE GE +EE + E E E+ ++ EE
Sbjct: 707 GEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGE--GEEV 764
Query: 410 DGEAGAED-KRSQEETPGHRRKEAEGTEEGGEEEDDEE 446
+GE E+ +R +EE G KE +G EEG + E +EE
Sbjct: 765 EGEREKEEGERKKEERAG---KEEKGEEEGDQGEGEEE 799
Score = 54.7 bits (130), Expect = 2e-07
Identities = 41/150 (27%), Positives = 69/150 (46%), Gaps = 10/150 (6%)
Query: 340 GARQRGLGGRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERAR 399
G + G GRG EE S E + E+ +G +++ E E E E E E E +
Sbjct: 645 GEAEDGPEGRG-DGTCEEGSSGAEHWQDEEREKGEKDKGRGEMERPGEGEKELAEKEEWK 703
Query: 400 QNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELS 459
+ E+++ E G + +R+QE G + EG EE G+ E++EE + +
Sbjct: 704 KRDGEEQEQKEREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGE--------- 754
Query: 460 TKLHLPADDVVSIIEEVEEKRKRKKNAPPE 489
K ++V E+ E +RK+++ A E
Sbjct: 755 GKEEGEGEEVEGEREKEEGERKKEERAGKE 784
Score = 52.0 bits (123), Expect = 2e-06
Identities = 47/157 (29%), Positives = 68/157 (43%), Gaps = 26/157 (16%)
Query: 291 EAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRG 350
E GE + G + E G R+ E ++ +EE + G R++ G R
Sbjct: 729 EGGEE--EHGEGEEEEGDREEEEEKEGEGKEEGEGEEVE----------GEREKEEGERK 776
Query: 351 LQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEA-EAEEAERARQNALLFAEEE 409
+E A + E EE + + E GEE EE E E E EE + R+ EEE
Sbjct: 777 KEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREE-----EEE 831
Query: 410 DGEAGAEDKRSQEETPGHRRKEAEGTEEGGE-EEDDE 445
+GE E+ +EE E EG EE GE + ++E
Sbjct: 832 EGEGEEEEGEGEEE-------EGEGEEEEGEGKGEEE 861
Score = 50.1 bits (118), Expect = 6e-06
Identities = 41/123 (33%), Positives = 59/123 (47%), Gaps = 21/123 (17%)
Query: 340 GARQRGLG-----GRGLQEAAEERE----SAREEEEAEQERRGGEERVGEEDEEAAEAEA 390
G + +G G G G +E AE+ E E+E+ E+E+ +ER E +E E
Sbjct: 677 GEKDKGRGEMERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQEMEEGGEEEHG 736
Query: 391 EAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEE-----GGEEEDDE 445
E EE E R+ EEE+ E +++ EE G R KE EG + G EE+ +E
Sbjct: 737 EGEEEEGDRE------EEEEKEGEGKEEGEGEEVEGEREKE-EGERKKEERAGKEEKGEE 789
Query: 446 EMD 448
E D
Sbjct: 790 EGD 792
Score = 40.4 bits (93), Expect = 0.005
Identities = 43/170 (25%), Positives = 64/170 (37%), Gaps = 33/170 (19%)
Query: 289 GSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGG 348
G E GE ++G + E + E + +E +G + G G
Sbjct: 966 GEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEE-------------EGEGEEEG-EG 1011
Query: 349 RGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNA------ 402
G +E E E E EE E E GEE GEE+ E E E E EE R R+
Sbjct: 1012 EGEEEEEGEVEGEVEGEEGEGE---GEEEEGEEEGEEREKEGEGEENRRNREEEEEEEGK 1068
Query: 403 -LLFAEEEDGEAGAEDKRSQEETPG---------HRRKEAEGTEEGGEEE 442
EEE+ E+ + + G +++K T+ G+E+
Sbjct: 1069 YQETGEEENERQDGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQ 1118
Score = 36.6 bits (83), Expect = 0.070
Identities = 28/103 (27%), Positives = 47/103 (45%), Gaps = 7/103 (6%)
Query: 353 EAAEERESAREEEE---AEQERRGGEERV----GEEDEEAAEAEAEAEEAERARQNALLF 405
E EE+E A + + EQE EE V G +++ ++ ++AE + A
Sbjct: 585 EIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKSV 644
Query: 406 AEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMD 448
E EDG G D +E + G + E E+G +++ EM+
Sbjct: 645 GEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEME 687
>gi|55741677 SET domain containing 1A [Homo sapiens]
Length = 1707
Score = 65.1 bits (157), Expect = 2e-10
Identities = 165/708 (23%), Positives = 234/708 (33%), Gaps = 168/708 (23%)
Query: 26 GRPEAQPPPLSSEHKEPV-AGDAVPGPKDGSAPEVRGARNSEPQDEGELFQGVDPRALAA 84
G PPP + ++ G PG S P+ G + P G+ + D
Sbjct: 535 GHGPCTPPPAPANFEDVAPTGSGEPGATRES-PKANGQNQASPCSSGDDMEISDD----- 588
Query: 85 VLLQALDRPASPP-APSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPPRPQ-- 141
DR SPP AP+ QQ P + S P P P PPRP
Sbjct: 589 ------DRGGSPPPAPTPPQQPPPPPPPPPPPPPYLASLPLGYP-PHQPAYLLPPRPDGP 641
Query: 142 -TPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQETAAAETE--TRTHTLTRVN-- 196
PE P P + + SL EL D + + +T+ TR H L +
Sbjct: 642 PPPEYPPPPPPPPHIYDFVNSL--ELMDRLGAQWGGMPMSFQMQTQMLTRLHQLRQGKGL 699
Query: 197 --------------------------------LESPGPERVWRASWGEFQARVPERA-PL 223
L + G E S + +P A PL
Sbjct: 700 IAASAGPPGGAFGEAFLPFPPPQEAAYGLPYALYAQGQEGRGAYSREAYHLPMPMAAEPL 759
Query: 224 PPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTH-LGEALAPLSKAYQGVAAPFPKARRP 282
P + S +AR+P E + EG + P +G LA L + + + +
Sbjct: 760 PSSSVSGEEARLPPR----EEAELAEGKTLPTAGTVGRVLAMLVQEMKSIMQRDLNRKMV 815
Query: 283 ESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEER----LADLASDLLLQYLLQ 338
E+ G + Q ++ E + A +Q A +E++ L + L+ +
Sbjct: 816 ENVAFGAFD------QWWESKEEKAKPFQNAAKQQAKEEDKEKTKLKEPGLLSLVDWAKS 869
Query: 339 GG-----ARQRGLGGRG---LQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEA 390
GG A G G RG L +R+ E EA +E+R EEDE+ E E
Sbjct: 870 GGTTGIEAFAFGSGLRGALRLPSFKVKRKEPSEISEASEEKRPRPSTPAEEDEDDPEQEK 929
Query: 391 EA-------------------------------EEAERARQNALLFAEEEDGEAGAEDKR 419
EA E E A Q + +EED E ED+
Sbjct: 930 EAGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDDEEDEEDE- 988
Query: 420 SQEETPGHRRKEAEGTEEGGEEED---------------DEEMDPQTIDSLIELSTKLHL 464
+EE +KE E ++ EE D D D ++ S S+
Sbjct: 989 DREEAVDTTKKETEVSDGEDEESDSSSKCSLYADSDGENDSTSDSESSSSSSSSSSSSSS 1048
Query: 465 PADDVVSIIEEV---EEKRKRKKNAPPEPVPPPRAAPAPT----HVRSPQ-----PPPPA 512
+ S E +E+ + + A P PPPR P PT V P+ P P
Sbjct: 1049 SSSSSSSSSSESSSEDEEEEERPAALPSASPPPREVPVPTPAPVEVPVPERVAGSPVTPL 1108
Query: 513 P----APAR-----DELPDWNEVLPPWDREEDEVYPPGPY-HPFPNYIRPRTLQPPSALR 562
P +PAR +E P + PP E PP P P P L PP R
Sbjct: 1109 PEQEASPARPAGPTEESPPSAPLRPP----EPPAGPPAPAPRPDERPSSPIPLLPPPKKR 1164
Query: 563 RRHYHH-------------ALPPSRHYPGREAQARRAQEEAEAEERRL 597
R+ A PP +PG +R+A E R L
Sbjct: 1165 RKTVSFSAIEVVPAPEPPPATPPQAKFPG--PASRKAPRGVERTIRNL 1210
Score = 52.8 bits (125), Expect = 9e-07
Identities = 112/530 (21%), Positives = 170/530 (32%), Gaps = 101/530 (19%)
Query: 22 AAPPGRPEAQPPPLSSEHKEPVAGDAVPGPKDGSAPEVRGARNSEPQDEGELFQGVDPRA 81
A PGRP +PP E + D E +SE +E +
Sbjct: 931 AGEPGRPGTKPPKRDEERGKTQGKHRKSFALDSEGEEASQESSSEKDEEDD--------- 981
Query: 82 LAAVLLQALDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPPRPQ 141
++ E+E E + T + S E + ++
Sbjct: 982 ---------------------EEDEEDEDREEAVDTTKKETEVSDGEDEESDSSSKCSLY 1020
Query: 142 TPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPG 201
+G S E + +S S SS+ +++E E + SP
Sbjct: 1021 ADSDGENDSTSDSESSSSSSSSSSSSSSSSSSSSSSSSESSSEDEEEEERPAALPSASPP 1080
Query: 202 PERVWRASWGEFQARVPERAPLPP--PAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLG 259
P V + + VPER P P P Q + +GP E+ + P+ G
Sbjct: 1081 PREVPVPTPAPVEVPVPERVAGSPVTPLPEQEASPARPAGPTEESPP-SAPLRPPEPPAG 1139
Query: 260 EALAPLSKAYQGVAAPFPKARRPESALLGGSEAGERLL---QQGLAQVEAGRRQAEATRQ 316
AP + + ++P P P+ S + ++ + A + A+R+
Sbjct: 1140 PP-APAPRPDERPSSPIPLLPPPKKRRKTVSFSAIEVVPAPEPPPATPPQAKFPGPASRK 1198
Query: 317 AAAQEER-LADLASD---LLLQY--LLQGGARQRGLGGRGLQEAAEERESAREEEEA--- 367
A ER + +L D L+ + + G R R GGRG EE E E + A
Sbjct: 1199 APRGVERTIRNLPLDHASLVKSWPEEVSRGGRSRA-GGRGRLTEEEEAEPGTEVDLAVLA 1257
Query: 368 ----EQERRGGEERVGEEDEEAAEAEAEAEE----------------------------- 394
RRG ED EA E EAE
Sbjct: 1258 DLALTPARRGLPALPAVEDSEATETSDEAERPRPLLSHILLEHNYALAVKPTPPAPALRP 1317
Query: 395 AERARQNALLFAEEEDG--------EAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEE 446
E A LF+ D A AE+ + Q+ E EG EEG EEE++
Sbjct: 1318 PEPVPAPAALFSSPADEVLEAPEVVVAEAEEPKPQQLQQQREEGEEEGEEEGEEEEEESS 1377
Query: 447 MDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKRKRKKNAPPEPVPPPRA 496
+ D L + + +R++ PP P PPPRA
Sbjct: 1378 DSSSSSDGEGALRRR-------------SLRSHARRRRPPPPPPPPPPRA 1414
Score = 33.5 bits (75), Expect = 0.59
Identities = 41/179 (22%), Positives = 58/179 (32%), Gaps = 39/179 (21%)
Query: 93 PASPPAPSGSQQG--PEEEAAEALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEAS 150
P PP P G G P E R + + P P SP + P P+T +
Sbjct: 434 PPEPPEPGGGGGGGGPSPE----------REEVRTSPRPASPARSGSPAPETTNESVPFA 483
Query: 151 DPSEELEALASLLQELR---DFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWR 207
S + LL+E R F S + ++E ++ R + GP
Sbjct: 484 QHSSLDSRIEMLLKEQRSKFSFLASDTEEEEENSSMVLGARDTGSEVPSGSGHGP----- 538
Query: 208 ASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLS 266
PPPAP+ F+ P P G SPK + +P S
Sbjct: 539 --------------CTPPPAPANFEDVAPTGSGEP-----GATRESPKANGQNQASPCS 578
>gi|155030232 proline, glutamic acid and leucine rich protein 1 [Homo
sapiens]
Length = 1130
Score = 63.9 bits (154), Expect = 4e-10
Identities = 61/201 (30%), Positives = 84/201 (41%), Gaps = 21/201 (10%)
Query: 352 QEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDG 411
+E EE E EEEE E+E EE +E+E E E E EE E EEE+G
Sbjct: 888 EEEEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEE-------FEEEEG 940
Query: 412 EAGAEDKRSQEETPGHRRKEAEGTEEG--GEEEDDEEMDPQTIDSLI---ELSTKLHLPA 466
E E++ EE +E E E G G E ++ P T+ + E K+
Sbjct: 941 ELEEEEEEEDEEEE-EELEEVEDLEFGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEP 999
Query: 467 DDVVSIIEEVEEK-RKRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNE 525
+ ++ EVEE + ++ A P P A P+ V + PA P EL +
Sbjct: 1000 EPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVER-EGESPAAGPPPQELVEEEP 1058
Query: 526 VLPPWDREE------DEVYPP 540
PP EE D+V PP
Sbjct: 1059 SAPPTLLEEETEDGSDKVQPP 1079
Score = 58.9 bits (141), Expect = 1e-08
Identities = 68/264 (25%), Positives = 95/264 (35%), Gaps = 56/264 (21%)
Query: 361 AREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRS 420
A EE+ +E EE+EE E E E EE E + EEED E E++
Sbjct: 873 ALEEDLTVININSSDEEEEEEEEEEEEEEEEEEEEEDFEE------EEEDEEEYFEEEEE 926
Query: 421 QEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKR 480
+EE +E EG E EEE+DEE + + +EEVE+
Sbjct: 927 EEEEFEEEFEEEEGELEEEEEEEDEEEEEE----------------------LEEVEDLE 964
Query: 481 ------KRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPA-------PARDELPDWN--- 524
+ ++ APP P PP P + + P P P P +E +
Sbjct: 965 FGTAGGEVEEGAPPPPTLPPALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAP 1024
Query: 525 ----EVLPPWDREEDEVYPPGPYHPFPNYIRPRTLQPPSALRRRHYHHA--LPPSRHYPG 578
E LP E E P P + PP+ L + + P P
Sbjct: 1025 TLAPEALPSQGEVEREGESPAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPA 1084
Query: 579 REAQARRAQEEAEAEERRLQEQEE 602
E + E E E LQE+E+
Sbjct: 1085 EE------EMETETEAEALQEKEQ 1102
Score = 51.2 bits (121), Expect = 3e-06
Identities = 45/151 (29%), Positives = 57/151 (37%), Gaps = 24/151 (15%)
Query: 457 ELSTKLHLPADDVVSIIEEVEEKRKRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPA 516
++ L +DD V I+ E PP P PPP A P + P P PA
Sbjct: 775 DVEISLESDSDDSVVIVPE---------GLPPLPPPPPSGATPPPIAPTGPPTASPPVPA 825
Query: 517 R---DELPDWNEVLPPWDREEDEVYPPGPYHPFPNYIRPRTLQPPSALRRRHYHHALPPS 573
+ +ELP LPP PP P P P P TL PP + PP+
Sbjct: 826 KEEPEELPAAPGPLPP---------PPPPPPPVPG---PVTLPPPQLVPEGTPGGGGPPA 873
Query: 574 RHYPGREAQARRAQEEAEAEERRLQEQEELE 604
+ EE E EE +E+EE E
Sbjct: 874 LEEDLTVININSSDEEEEEEEEEEEEEEEEE 904
Score = 36.2 bits (82), Expect = 0.091
Identities = 97/438 (22%), Positives = 142/438 (32%), Gaps = 72/438 (16%)
Query: 15 LLINGLGAAPPGRPEAQPPPLSSEHKEPVAGDAVPGPKDGSAPEVRGAR---------NS 65
L + GL + PP + +++P+ + P E G R +
Sbjct: 711 LSVPGLVSVPPRLLPGPENHRAGSNEDPILAPSGTPPPTIPPDETFGGRVPRPAFVHYDK 770
Query: 66 EPQDEGELFQGVDPRALAAVLLQALDRPASPPAPSGSQQGPEEEAAEALLTETV--RSQT 123
E + E+ D ++ + L P PP PSG+ P + V + +
Sbjct: 771 EEASDVEISLESDSDDSVVIVPEGLP-PLPPPPPSGATPPPIAPTGPPTASPPVPAKEEP 829
Query: 124 HSLPAPESPEPAAPPRPQ-------------TPENGPEASDP---SEELEAL---ASLLQ 164
LPA P P PP P PE P P E+L + +S +
Sbjct: 830 EELPAAPGPLPPPPPPPPPVPGPVTLPPPQLVPEGTPGGGGPPALEEDLTVININSSDEE 889
Query: 165 ELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLP 224
E + + ++E + E E E + + E + + E
Sbjct: 890 EEEEEEEEEEEEEEEEEEEDFEEEEEDEEEYFEEEEEEEEEFEEEFEEEEGELEEEEEEE 949
Query: 225 PPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPES 284
+ + D + EG P T L AL P + P PE
Sbjct: 950 DEEEEEELEEVEDLEFGTAGGEVEEGAPPPPT-LPPALPPPESPPKVQPEP-----EPEP 1003
Query: 285 ALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYL-LQGGARQ 343
L L +VE + +EER AD A L + L QG +
Sbjct: 1004 GL--------------LLEVE----------EPGTEEERGADTAPTLAPEALPSQGEVER 1039
Query: 344 RG---LGGRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAE-EAERAR 399
G G QE EE SA E+E G ++V E AE E E E EAE
Sbjct: 1040 EGESPAAGPPPQELVEEEPSA-PPTLLEEETEDGSDKVQPPPETPAEEEMETETEAE--- 1095
Query: 400 QNALLFAEEEDGEAGAED 417
AL E++D A D
Sbjct: 1096 --ALQEKEQDDTAAMLAD 1111
Score = 32.3 bits (72), Expect = 1.3
Identities = 15/34 (44%), Positives = 19/34 (55%), Gaps = 3/34 (8%)
Query: 488 PEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELP 521
P PVPPP A P+ R+P PP P P+ +P
Sbjct: 648 PAPVPPPEA---PSPFRAPPFHPPGPMPSVGSMP 678
Score = 32.3 bits (72), Expect = 1.3
Identities = 49/162 (30%), Positives = 66/162 (40%), Gaps = 29/162 (17%)
Query: 24 PPGRPEAQPPPLSSEHKEPVAGDAVPGPKDGSAPEVRGARNSEPQDEGELFQGVD----- 78
PP P A PPP S +P P P+ G EV EP E E +G D
Sbjct: 979 PPTLPPALPPPESPPKVQP-----EPEPEPGLLLEV-----EEPGTEEE--RGADTAPTL 1026
Query: 79 -PRALAA--VLLQALDRPASPPAPSGSQQGPEEE--AAEALLTETVRSQTHSLPAPESPE 133
P AL + + + + PA+ P P Q+ EEE A LL E + + P PE
Sbjct: 1027 APEALPSQGEVEREGESPAAGPPP---QELVEEEPSAPPTLLEEETEDGSDKVQPP--PE 1081
Query: 134 PAAPPRPQTPENGPEASDPSEELEALASLLQELRDFSPSSAK 175
A +T E EA E+ + A++L + D P K
Sbjct: 1082 TPAEEEMET-ETEAEALQEKEQ-DDTAAMLADFIDCPPDDEK 1121
Score = 32.3 bits (72), Expect = 1.3
Identities = 40/148 (27%), Positives = 52/148 (35%), Gaps = 20/148 (13%)
Query: 93 PASPPAPSGSQQGPEEEAAEALLTETVRSQTH----SLPAPESPEPAAPPRPQTPENG-- 146
PA PP S + PE E LL E T + AP A P + + G
Sbjct: 984 PALPPPESPPKVQPEPEPEPGLLLEVEEPGTEEERGADTAPTLAPEALPSQGEVEREGES 1043
Query: 147 PEASDPSEEL-----EALASLLQELRDFSPSSAKRQQETAA---AETETRTHTLTRVNLE 198
P A P +EL A +LL+E + + ET A ETET L +
Sbjct: 1044 PAAGPPPQELVEEEPSAPPTLLEEETEDGSDKVQPPPETPAEEEMETETEAEALQEKEQD 1103
Query: 199 SPGPERVWRASWGEFQARVPERAPLPPP 226
A +F P+ PPP
Sbjct: 1104 DTA------AMLADFIDCPPDDEKPPPP 1125
>gi|102467242 inner centromere protein antigens 135/155kDa isoform 2
[Homo sapiens]
Length = 914
Score = 63.5 bits (153), Expect = 5e-10
Identities = 111/496 (22%), Positives = 192/496 (38%), Gaps = 65/496 (13%)
Query: 129 PESPEPAAPPRPQTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQETAAA---ET 185
PE EP A P+ PEN S P + E S +P A ET +A E
Sbjct: 379 PEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTP------NPKPAASSPETPSAGQQEA 432
Query: 186 ETRTHTLTRVNLESPGPERVWRASWGEF-QARVPERAPLPPPAPSQFQARMPDSGPLPET 244
+T R +S +R ++ + E + + E L PP + P S +
Sbjct: 433 KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPL 492
Query: 245 HKFGEGVSSPKTHLGEALAPLS--KAYQGVAAPF---PKAR-RPESALLGGSEAGERLLQ 298
F V + + AP S K++ P PK + R L E E+L +
Sbjct: 493 RTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKEKERQRLENLRRKEEAEQLRR 552
Query: 299 QGLAQVEAGR------RQAEATRQAAAQEERLADLASDLLLQ----YLLQGGARQRGLGG 348
Q + + + R ++ E R+ ER+ + + Q + ++
Sbjct: 553 QKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEKAKEE 612
Query: 349 RGLQEAAEERESAREEEEAEQERRGGEER-----VGEEDEEAAEAEA----EAEEAERAR 399
R +E A+++ +A++ EE E R+ EE + +E+EE E + EE ER R
Sbjct: 613 RLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQERLR 672
Query: 400 Q--NALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIE 457
+ A AE+ + E +++R QE RR++ +E E + + + + + E
Sbjct: 673 KAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQAERE 732
Query: 458 LSTK---LHLPADDVVSIIEEVEEKRKRKKNA-----------PPEPVPPPRAAPAPTHV 503
L + L L + + +EE ++K ++++ A E +A V
Sbjct: 733 LQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNVTVDV 792
Query: 504 RSP------QPPPPAPAPARDELPDWNEVLPPWDREEDEVYPPGPYHPFPNYIRPRTLQP 557
+SP P AP + ++ L D +DE + P P P + R L
Sbjct: 793 QSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAH---PRKPIPTWARGTPLS- 848
Query: 558 PSALRRRHYHHALPPS 573
A+ ++YH PP+
Sbjct: 849 -QAIIHQYYH---PPN 860
>gi|102467235 inner centromere protein antigens 135/155kDa isoform 1
[Homo sapiens]
Length = 918
Score = 63.2 bits (152), Expect = 7e-10
Identities = 108/500 (21%), Positives = 189/500 (37%), Gaps = 69/500 (13%)
Query: 129 PESPEPAAPPRPQTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQETAAA---ET 185
PE EP A P+ PEN S P + E S +P A ET +A E
Sbjct: 379 PEEAEPVAAAEPEVPENNGNNSWPHNDTEIANSTP------NPKPAASSPETPSAGQQEA 432
Query: 186 ETRTHTLTRVNLESPGPERVWRASWGEF-QARVPERAPLPPPAPSQFQARMPDSGPLPET 244
+T R +S +R ++ + E + + E L PP + P S +
Sbjct: 433 KTDQADGPREPPQSARRKRSYKQAVSELDEEQHLEDEELQPPRSKTPSSPCPASKVVRPL 492
Query: 245 HKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESAL----------LGGSEAGE 294
F V + + AP S + P P+ + L E E
Sbjct: 493 RTFLHTVQRNQMLMTPTSAPRSVMKSFIKRNTPLRMDPKCSFVEKERQRLENLRRKEEAE 552
Query: 295 RLLQQGLAQVEAGR------RQAEATRQAAAQEERLADLASDLLLQ----YLLQGGARQR 344
+L +Q + + + R ++ E R+ ER+ + + Q + ++
Sbjct: 553 QLRRQKVEEDKRRRLEEVKLKREERLRKVLQARERVEQMKEEKKKQIEQKFAQIDEKTEK 612
Query: 345 GLGGRGLQEAAEERESAREEEEAEQERRGGEER-----VGEEDEEAAEAEA----EAEEA 395
R +E A+++ +A++ EE E R+ EE + +E+EE E + EE
Sbjct: 613 AKEERLAEEKAKKKAAAKKMEEVEARRKQEEEARRLRWLQQEEEERRHQELLQKKKEEEQ 672
Query: 396 ERARQ--NALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTID 453
ER R+ A AE+ + E +++R QE RR++ +E E + + + +
Sbjct: 673 ERLRKAAEAKRLAEQREQERREQERREQERREQERREQERREQERQLAEQERRREQERLQ 732
Query: 454 SLIELSTK---LHLPADDVVSIIEEVEEKRKRKKNA-----------PPEPVPPPRAAPA 499
+ EL + L L + + +EE ++K ++++ A E +A
Sbjct: 733 AERELQEREKALRLQKEQLQRELEEKKKKEEQQRLAERQLQEEQEKKAKEAAGASKALNV 792
Query: 500 PTHVRSP------QPPPPAPAPARDELPDWNEVLPPWDREEDEVYPPGPYHPFPNYIRPR 553
V+SP P AP + ++ L D +DE + P P P + R
Sbjct: 793 TVDVQSPACTSYQMTPQGHRAPPKINPDNYGMDLNSDDSTDDEAH---PRKPIPTWARGT 849
Query: 554 TLQPPSALRRRHYHHALPPS 573
L A+ ++YH PP+
Sbjct: 850 PLS--QAIIHQYYH---PPN 864
>gi|157738649 neurofilament, medium polypeptide 150kDa isoform 1
[Homo sapiens]
Length = 916
Score = 62.4 bits (150), Expect = 1e-09
Identities = 55/184 (29%), Positives = 78/184 (42%), Gaps = 31/184 (16%)
Query: 352 QEAAEERESAREEEEAEQERRGG----------EERVGEEDEEAAEAEAEAEEAERARQN 401
+EAAEE+E E EE E + EE +E+EE E E E +E ++ Q
Sbjct: 489 KEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQ- 547
Query: 402 ALLFAEEEDGE-AGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELST 460
AEE E G+ +K E+ G EAEG E +EE E + E++T
Sbjct: 548 ----AEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSE------EVAT 597
Query: 461 KLHLPADDVVSIIEEVEEKRKRKKNAPPEPVPPPRAAP---APTHVRSPQPPPPAPAPAR 517
K L AD +VE+ K K P PV +P +P + P P +P +
Sbjct: 598 KEELVAD------AKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEK 651
Query: 518 DELP 521
+ P
Sbjct: 652 GKSP 655
Score = 60.8 bits (146), Expect = 3e-09
Identities = 56/249 (22%), Positives = 98/249 (39%), Gaps = 15/249 (6%)
Query: 356 EERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGA 415
EE++ A EE+E E E E + +A E + EE E+ + EEED A
Sbjct: 486 EEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGA-- 543
Query: 416 EDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEE 475
K Q E G ++ + EEG +EE + E + + ++ + K+ +++V + E
Sbjct: 544 --KSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEEL 601
Query: 476 VEEKRKRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVLPPWDREED 535
V + + K PVP +P + P P +P + + P P E+
Sbjct: 602 VADAKVEKPEKAKSPVP-----KSPVEEKGKSPVPKSPVEEKGKSP------VPKSPVEE 650
Query: 536 EVYPPGPYHPFPNYIRPRTLQPPSALRRRHYHHALPPSRHYPGREAQARRAQEEAEAEER 595
+ P P P + + P + + P E +EE E E +
Sbjct: 651 KGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVK 710
Query: 596 RLQEQEELE 604
++E++E
Sbjct: 711 EAPKEEKVE 719
Score = 48.9 bits (115), Expect = 1e-05
Identities = 51/193 (26%), Positives = 79/193 (40%), Gaps = 24/193 (12%)
Query: 350 GLQEAAEERESAREE--EEAEQERRGGEERV-GEEDEEAAEAEAEAEEAERARQNALLFA 406
G +E EE E A+ + EE E+ G E+ GE++E EAEAE EEAE + +
Sbjct: 532 GQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKV--- 588
Query: 407 EEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPA 466
EE+ E +++ + K + EE + P+ S +E K +P
Sbjct: 589 EEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPK---SPVEEKGKSPVPK 645
Query: 467 DDVVSIIEEVEEKRKRKKNAPPEPVPPPRAAP---APTHVRSPQPPPPAPAPARDELPDW 523
V + K K P PV +P +P ++ P P +P +E
Sbjct: 646 SPV---------EEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPV---EEAKSK 693
Query: 524 NEVLPPWDREEDE 536
EV +EE+E
Sbjct: 694 AEVGKGEQKEEEE 706
Score = 42.4 bits (98), Expect = 0.001
Identities = 75/318 (23%), Positives = 121/318 (38%), Gaps = 50/318 (15%)
Query: 224 PPPAPSQFQARMPDSGPLPETHKFGEG------VSSPKTHLGEALAPLSKAYQGVAAPFP 277
P S+ Q ++ L HKF E V K+ + EAL +++ A
Sbjct: 429 PITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEEL----AVSM 484
Query: 278 KARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLL 337
K + E+A E E + +V A + +AT +EE + +
Sbjct: 485 KEEKKEAA-----EEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEE 539
Query: 338 QGGAR--QRGLGGRGLQEAAEERESAREEEEAEQERRG------GEERVGEEDEEAAE-- 387
GA+ Q GG + ++E+ E +EE E E E G E++V E+ EE A
Sbjct: 540 DEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKE 599
Query: 388 ---AEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRK---EAEGTEEGGEE 441
A+A+ E+ E+A+ EE G++ +E+ K E +G +
Sbjct: 600 ELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 659
Query: 442 EDDEEMDPQTIDSLIELSTKLHLPADDV--------VSIIEEVEEKRKRKKNAP------ 487
+E+ S +E K +P V V E+ EE+ K K AP
Sbjct: 660 PVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVE 719
Query: 488 -----PEPVPPPRAAPAP 500
P+ VP + A +P
Sbjct: 720 KKEEKPKDVPEKKKAESP 737
Score = 42.0 bits (97), Expect = 0.002
Identities = 76/371 (20%), Positives = 141/371 (38%), Gaps = 37/371 (9%)
Query: 102 SQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELE---- 157
S + ++EAAE E ++ + A +SP A P + E E + EE E
Sbjct: 483 SMKEEKKEAAEEK-EEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDE 541
Query: 158 -ALASLLQEL-RDFSPSSAKRQQETAAAETETRTH-----TLTRVNLESPGPERVWRASW 210
A + +E + SS K + E ETE +E E +
Sbjct: 542 GAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEEL 601
Query: 211 -GEFQARVPERAPLP-PPAPSQFQARMP-DSGPLPETHKFGEGVSSPKTHLGEALAPLSK 267
+ + PE+A P P +P + + + P P+ E K SP G++ P S
Sbjct: 602 VADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGK-SPVPKSPVEEKGKSPVPKSP 660
Query: 268 AYQGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADL 327
+ +P K+ E A S + +++ ++ E G+ + Q +E+ + +
Sbjct: 661 VEEKGKSPVSKSPVEEKAK---SPVPKSPVEEAKSKAEVGKGE-----QKEEEEKEVKEA 712
Query: 328 ASDLLLQYLLQGGARQRGLGGRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAE 387
+ ++ ++ + + E + +EE AE +V E E E
Sbjct: 713 PKEEKVE--------KKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEE 764
Query: 388 AEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQE-----ETPGHRRKEAEGTEEGGEEE 442
+ +E E+ + +EEE + GA+ R ++ E G E E E+G E
Sbjct: 765 GKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGRE 824
Query: 443 DDEEMDPQTID 453
+++ + +D
Sbjct: 825 EEKGVVTNGLD 835
>gi|157738641 neurofilament, medium polypeptide 150kDa isoform 2
[Homo sapiens]
Length = 540
Score = 62.4 bits (150), Expect = 1e-09
Identities = 55/184 (29%), Positives = 78/184 (42%), Gaps = 31/184 (16%)
Query: 352 QEAAEERESAREEEEAEQERRGG----------EERVGEEDEEAAEAEAEAEEAERARQN 401
+EAAEE+E E EE E + EE +E+EE E E E +E ++ Q
Sbjct: 113 KEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGAKSDQ- 171
Query: 402 ALLFAEEEDGE-AGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELST 460
AEE E G+ +K E+ G EAEG E +EE E + E++T
Sbjct: 172 ----AEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSE------EVAT 221
Query: 461 KLHLPADDVVSIIEEVEEKRKRKKNAPPEPVPPPRAAP---APTHVRSPQPPPPAPAPAR 517
K L AD +VE+ K K P PV +P +P + P P +P +
Sbjct: 222 KEELVAD------AKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEK 275
Query: 518 DELP 521
+ P
Sbjct: 276 GKSP 279
Score = 60.8 bits (146), Expect = 3e-09
Identities = 56/249 (22%), Positives = 98/249 (39%), Gaps = 15/249 (6%)
Query: 356 EERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGA 415
EE++ A EE+E E E E + +A E + EE E+ + EEED A
Sbjct: 110 EEKKEAAEEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDEGA-- 167
Query: 416 EDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEE 475
K Q E G ++ + EEG +EE + E + + ++ + K+ +++V + E
Sbjct: 168 --KSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEEL 225
Query: 476 VEEKRKRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVLPPWDREED 535
V + + K PVP +P + P P +P + + P P E+
Sbjct: 226 VADAKVEKPEKAKSPVP-----KSPVEEKGKSPVPKSPVEEKGKSP------VPKSPVEE 274
Query: 536 EVYPPGPYHPFPNYIRPRTLQPPSALRRRHYHHALPPSRHYPGREAQARRAQEEAEAEER 595
+ P P P + + P + + P E +EE E E +
Sbjct: 275 KGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVK 334
Query: 596 RLQEQEELE 604
++E++E
Sbjct: 335 EAPKEEKVE 343
Score = 48.9 bits (115), Expect = 1e-05
Identities = 51/193 (26%), Positives = 79/193 (40%), Gaps = 24/193 (12%)
Query: 350 GLQEAAEERESAREE--EEAEQERRGGEERV-GEEDEEAAEAEAEAEEAERARQNALLFA 406
G +E EE E A+ + EE E+ G E+ GE++E EAEAE EEAE + +
Sbjct: 156 GQEEEEEEDEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKV--- 212
Query: 407 EEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPA 466
EE+ E +++ + K + EE + P+ S +E K +P
Sbjct: 213 EEKSEEVATKEELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPK---SPVEEKGKSPVPK 269
Query: 467 DDVVSIIEEVEEKRKRKKNAPPEPVPPPRAAP---APTHVRSPQPPPPAPAPARDELPDW 523
V + K K P PV +P +P ++ P P +P +E
Sbjct: 270 SPV---------EEKGKSPVPKSPVEEKGKSPVSKSPVEEKAKSPVPKSPV---EEAKSK 317
Query: 524 NEVLPPWDREEDE 536
EV +EE+E
Sbjct: 318 AEVGKGEQKEEEE 330
Score = 42.4 bits (98), Expect = 0.001
Identities = 75/318 (23%), Positives = 121/318 (38%), Gaps = 50/318 (15%)
Query: 224 PPPAPSQFQARMPDSGPLPETHKFGEG------VSSPKTHLGEALAPLSKAYQGVAAPFP 277
P S+ Q ++ L HKF E V K+ + EAL +++ A
Sbjct: 53 PITISSKIQKPKVEAPKLKVQHKFVEEIIEETKVEDEKSEMEEALTAITEEL----AVSM 108
Query: 278 KARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLL 337
K + E+A E E + +V A + +AT +EE + +
Sbjct: 109 KEEKKEAA-----EEKEEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEE 163
Query: 338 QGGAR--QRGLGGRGLQEAAEERESAREEEEAEQERRG------GEERVGEEDEEAAE-- 387
GA+ Q GG + ++E+ E +EE E E E G E++V E+ EE A
Sbjct: 164 DEGAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKE 223
Query: 388 ---AEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRK---EAEGTEEGGEE 441
A+A+ E+ E+A+ EE G++ +E+ K E +G +
Sbjct: 224 ELVADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKSPVEEKGKSPVPKS 283
Query: 442 EDDEEMDPQTIDSLIELSTKLHLPADDV--------VSIIEEVEEKRKRKKNAP------ 487
+E+ S +E K +P V V E+ EE+ K K AP
Sbjct: 284 PVEEKGKSPVSKSPVEEKAKSPVPKSPVEEAKSKAEVGKGEQKEEEEKEVKEAPKEEKVE 343
Query: 488 -----PEPVPPPRAAPAP 500
P+ VP + A +P
Sbjct: 344 KKEEKPKDVPEKKKAESP 361
Score = 42.0 bits (97), Expect = 0.002
Identities = 76/371 (20%), Positives = 141/371 (38%), Gaps = 37/371 (9%)
Query: 102 SQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELE---- 157
S + ++EAAE E ++ + A +SP A P + E E + EE E
Sbjct: 107 SMKEEKKEAAEEK-EEEPEAEEEEVAAKKSPVKATAPEVKEEEGEKEEEEGQEEEEEEDE 165
Query: 158 -ALASLLQEL-RDFSPSSAKRQQETAAAETETRTH-----TLTRVNLESPGPERVWRASW 210
A + +E + SS K + E ETE +E E +
Sbjct: 166 GAKSDQAEEGGSEKEGSSEKEEGEQEEGETEAEAEGEEAEAKEEKKVEEKSEEVATKEEL 225
Query: 211 -GEFQARVPERAPLP-PPAPSQFQARMP-DSGPLPETHKFGEGVSSPKTHLGEALAPLSK 267
+ + PE+A P P +P + + + P P+ E K SP G++ P S
Sbjct: 226 VADAKVEKPEKAKSPVPKSPVEEKGKSPVPKSPVEEKGK-SPVPKSPVEEKGKSPVPKSP 284
Query: 268 AYQGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADL 327
+ +P K+ E A S + +++ ++ E G+ + Q +E+ + +
Sbjct: 285 VEEKGKSPVSKSPVEEKAK---SPVPKSPVEEAKSKAEVGKGE-----QKEEEEKEVKEA 336
Query: 328 ASDLLLQYLLQGGARQRGLGGRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAE 387
+ ++ ++ + + E + +EE AE +V E E E
Sbjct: 337 PKEEKVE--------KKEEKPKDVPEKKKAESPVKEEAVAEVVTITKSVKVHLEKETKEE 388
Query: 388 AEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQE-----ETPGHRRKEAEGTEEGGEEE 442
+ +E E+ + +EEE + GA+ R ++ E G E E E+G E
Sbjct: 389 GKPLQQEKEKEKAGGEGGSEEEGSDKGAKGSRKEDIAVNGEVEGKEEVEQETKEKGSGRE 448
Query: 443 DDEEMDPQTID 453
+++ + +D
Sbjct: 449 EEKGVVTNGLD 459
>gi|78042577 MAP7 domain containing 1 [Homo sapiens]
Length = 841
Score = 62.0 bits (149), Expect = 2e-09
Identities = 92/364 (25%), Positives = 142/364 (39%), Gaps = 46/364 (12%)
Query: 92 RPASPPAPSGSQQGPE---EEAAEALLTETVRSQTHSLPA-PESPEPAAPPRPQTPENGP 147
RP + P ++ E E+ AL E + SLPA P + A+ +P++
Sbjct: 406 RPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPKSKA 465
Query: 148 EASDPSEELEALASLLQEL---RDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPE- 203
S PS AS P + TA+ + R + + + GPE
Sbjct: 466 RPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGPED 525
Query: 204 --RVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEA 261
+ R + E ++ P +P P PAPS A P ET ++SP
Sbjct: 526 KSQSKRRASNEKESAAPA-SPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPP------ 578
Query: 262 LAPLSKAYQGVAAPFPKARRPESALLGGSEAGE--RLLQQGLAQVEAGRRQAEATRQAAA 319
AP P P + G ++ E RLL + RRQA R+
Sbjct: 579 ------------APAPPVT-PSKPMAGTTDREEATRLLAEK-------RRQAREQREREE 618
Query: 320 QEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEERESAREEEEAEQERRGGEERVG 379
QE RL + + L A R R + E + ARE+ +AEQE +ER+
Sbjct: 619 QERRLQAERDKRMREEQLAREAEARA--EREAEARRREEQEAREKAQAEQEE---QERLQ 673
Query: 380 EEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGG 439
++ EE AEA + EEAER R ++++ E KR +E R+ E T++
Sbjct: 674 KQKEE-AEARSR-EEAERQRLEREKHFQQQEQERQERRKRLEEIMKRTRKSEVSETKQKQ 731
Query: 440 EEED 443
+ ++
Sbjct: 732 DSKE 735
Score = 42.7 bits (99), Expect = 0.001
Identities = 59/257 (22%), Positives = 91/257 (35%), Gaps = 13/257 (5%)
Query: 357 ERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAE 416
E +++E+ ++ER +E+ E + + + RAR +A +E ++
Sbjct: 408 EASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPASPRARLSASTASELSPK---SK 464
Query: 417 DKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEEV 476
+ S T HR + G + P+ + + + A + S
Sbjct: 465 ARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPKGRVRRKEEAKESPSAAGP- 523
Query: 477 EEKRKRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVLPPWDREEDE 536
E+K + K+ A E A+PAP+ SP P PP E P VL
Sbjct: 524 EDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPAETPTDAAVLTSPPAPAPP 583
Query: 537 VYPPGPY------HPFPNYIRPRTLQPPSALRRRHYHHALPPSRHYPGREAQARR---AQ 587
V P P + + Q R L R RE Q R A+
Sbjct: 584 VTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQAERDKRMREEQLAREAEAR 643
Query: 588 EEAEAEERRLQEQEELE 604
E EAE RR +EQE E
Sbjct: 644 AEREAEARRREEQEARE 660
Score = 40.8 bits (94), Expect = 0.004
Identities = 56/243 (23%), Positives = 86/243 (35%), Gaps = 51/243 (20%)
Query: 411 GEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLI----ELSTKLHLPA 466
GE G K + +P R+ E + +E+ D+E + + S + L + LPA
Sbjct: 386 GERGERRKPNAGGSPAPVRRRPEASPVQKKEKKDKERENEKEKSALARERSLKKRQSLPA 445
Query: 467 DD----VVSIIEEVEEKRKRKKNAPPEPVPPPRA---APAPTHVRSPQPPPPAPAPA--- 516
S E+ K K + ++P P + +P P H P+PP P A
Sbjct: 446 SPRARLSASTASELSPKSKARPSSPSTSWHRPASPCPSPGPGHTLPPKPPSPRGTTASPK 505
Query: 517 -----RDELPDWNEVLPPWDR---------EEDEVYPPGPY---HPFPNYIRPRTLQPPS 559
++E + P D+ E++ P P P P P+ QPP+
Sbjct: 506 GRVRRKEEAKESPSAAGPEDKSQSKRRASNEKESAAPASPAPSPAPSPTPAPPQKEQPPA 565
Query: 560 ALRRRHYHHALPPSRHYP-----------GREAQAR---------RAQEEAEAEERRLQE 599
PP+ P RE R R Q E E +ERRLQ
Sbjct: 566 ETPTDAAVLTSPPAPAPPVTPSKPMAGTTDREEATRLLAEKRRQAREQREREEQERRLQA 625
Query: 600 QEE 602
+ +
Sbjct: 626 ERD 628
Score = 38.9 bits (89), Expect = 0.014
Identities = 62/255 (24%), Positives = 102/255 (40%), Gaps = 33/255 (12%)
Query: 218 PERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFP 277
PE P PPP P A +PD+ P +T + +S K E +P G P P
Sbjct: 29 PEGDPSPPPPP--MSALVPDTPP--DTPPAMKNATSSKQLPLEPESP-----SGQVGPRP 79
Query: 278 KARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDL--LLQY 335
+ ES SEA R G G R A R+++ Q A ASD Q
Sbjct: 80 APPQEESP---SSEAKSR----GPTPPAMGPRDARPPRRSS-QPSPTAVPASDSPPTKQE 131
Query: 336 LLQGGARQRGLGGRGLQEAA-------------EERESAREEEEAEQERRGGEERVGEED 382
+ + G R + R + A E+ ++ RE++ E+ RR E+R+ E
Sbjct: 132 VKKAGERHKLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQERRRRLEEQRLKAEQ 191
Query: 383 EEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEE 442
AA E + ++ E+ ++ + + AE ++ + G + G + G
Sbjct: 192 RRAALEERQRQKLEKNKERYEAAIQRSVKKTWAEIRQQRWSWAGALHHSSPGHKTSGSRC 251
Query: 443 DDEEMD-PQTIDSLI 456
++ P+ +DS+I
Sbjct: 252 SVSAVNLPKHVDSII 266
Score = 33.5 bits (75), Expect = 0.59
Identities = 34/140 (24%), Positives = 48/140 (34%), Gaps = 31/140 (22%)
Query: 487 PPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVL------------------- 527
PPEP P P P+P PPPP A D PD +
Sbjct: 22 PPEPRPSPEGDPSP-------PPPPMSALVPDTPPDTPPAMKNATSSKQLPLEPESPSGQ 74
Query: 528 ----PPWDREEDEVYPPGPYHPFPNYIRPRTLQPPSALRRRHYHHALPPSRHYPGREAQA 583
P +EE P P + PR +PP + A+P S P ++
Sbjct: 75 VGPRPAPPQEESPSSEAKSRGPTPPAMGPRDARPPRR-SSQPSPTAVPASDSPPTKQEVK 133
Query: 584 RRAQEEAEAEERRLQEQEEL 603
+ + A+ERR + + L
Sbjct: 134 KAGERHKLAKERREERAKYL 153
Score = 30.4 bits (67), Expect = 5.0
Identities = 36/143 (25%), Positives = 51/143 (35%), Gaps = 11/143 (7%)
Query: 474 EEVEEKRKRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVLPPWDRE 533
+E + K P P PR A P RS QP P A PA D P EV +R
Sbjct: 83 QEESPSSEAKSRGPTPPAMGPRDARPPR--RSSQPSPTA-VPASDSPPTKQEVKKAGERH 139
Query: 534 ---EDEVYPPGPYHPFPNYIRPRTLQPPSALRRRHYHHALPPSRHYPGREAQARRAQEEA 590
++ Y + + ALR + R E + + Q A
Sbjct: 140 KLAKERREERAKYLAAKKAVWLEKEEKAKALREKQLQ-----ERRRRLEEQRLKAEQRRA 194
Query: 591 EAEERRLQEQEELENYIEHVLLR 613
EER+ Q+ E+ + E + R
Sbjct: 195 ALEERQRQKLEKNKERYEAAIQR 217
>gi|156766047 GRB10 interacting GYF protein 2 isoform c [Homo
sapiens]
Length = 1293
Score = 60.5 bits (145), Expect = 5e-09
Identities = 119/465 (25%), Positives = 174/465 (37%), Gaps = 79/465 (16%)
Query: 24 PPGRPEAQPPPLSSEHKEPVAGDAVPGPKDGSAPEVRGARNSEPQDEGELF----QGVDP 79
PP P P P + PV G G + G ++ E Q E + +D
Sbjct: 446 PP--PVPNPSPTLRPVETPVVGAPGMGSVSTEPDDEEGLKHLEQQAEKMVAYLQDSALDD 503
Query: 80 RALAAVLLQALDRPASPPA------------PSGSQQGP--EEEAAE---------ALLT 116
LA+ L + + S P P G QGP +E AE +LL
Sbjct: 504 ERLASKLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLV 563
Query: 117 ETVRSQTHSL---------PAPESPEPAAPPRPQTPENGPEASDPSEELEALASLL---- 163
+ ++ P SP PA PP E E +EL AL +
Sbjct: 564 KRACDESFQPLGDIMKMWGRVPFSPGPAPPPH--MGELDQERLTRQQELTALYQMQHLQY 621
Query: 164 -QELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAP 222
Q L + QQ+ AA ++ + + + + R+ ++
Sbjct: 622 QQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQ------------QFQTLKMRISDQNI 669
Query: 223 LPPPAPSQFQARMPDSGPL---------PETHKFGEGVSSP--KTHLGEALAPLSKAYQG 271
+P S +PD+G + P + G P T G AL L + +
Sbjct: 670 IPSVTRS---VSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKA 726
Query: 272 VAAPFPKARRPESALLGGSEAGERLLQQGLA--QVEAGRRQAEATRQAAAQEERLADLAS 329
AA + RR E+ + E ER Q+ L Q E RRQ E R+ +EE
Sbjct: 727 KAAKLEQERR-EAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQE 785
Query: 330 DLLLQYLLQGGA--RQRGLGGRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAE 387
+ L + Q A RQR R QE A R R EE +ERR EE + +++EEAA+
Sbjct: 786 EALRRQREQEIALRRQREEEERQQQEEALRRLEERRREE--EERRKQEELLRKQEEEAAK 843
Query: 388 AEAEAEEAE-RARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKE 431
E EEA+ R +N L EE E++R ++E R+KE
Sbjct: 844 WAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKE 888
Score = 45.1 bits (105), Expect = 2e-04
Identities = 34/129 (26%), Positives = 62/129 (48%), Gaps = 6/129 (4%)
Query: 356 EERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGA 415
++ E R ++E E++RR EE + EEA + E E A R ++ ++E+
Sbjct: 758 QQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRL 817
Query: 416 EDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEE 475
E++R +EE RRK+ E + EE + + +E + L ++ + +
Sbjct: 818 EERRREEE---ERRKQEELLRKQEEEAAKWAREEEEAQRRLE---ENRLRMEEEAARLRH 871
Query: 476 VEEKRKRKK 484
EE+RKRK+
Sbjct: 872 EEEERKRKE 880
Score = 37.0 bits (84), Expect = 0.054
Identities = 47/225 (20%), Positives = 88/225 (39%), Gaps = 26/225 (11%)
Query: 330 DLLLQYLLQGGARQRGL---GGRGLQEAAEERESAREEEEAE----QERRGGEERVGEED 382
D L ++ L+ + G G L ++E EE+E + E + G +
Sbjct: 277 DSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVDEGEECSDSEGSHN 336
Query: 383 EEAAEAE-AEAEEAERARQNALLFAEE------EDGEAGAEDKRSQEETPGHRRKEAEGT 435
EEA E + +E E+ + + +EE G +E RK+ T
Sbjct: 337 EEAKEPDKTNKKEGEKTDRVGVEASEETPQTSSSSARPGTPSDHQSQEASQFERKDEPKT 396
Query: 436 EEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKRKRKKNAPPEPVPPPR 495
E+ + E++ M+ L K+ D++V+ +++ + +P +PPP
Sbjct: 397 EQTEKAEEETRMENS-------LPAKVPSRGDEMVADVQQPLSQIPSDTASPLLILPPPV 449
Query: 496 AAPAPTHVRSPQPPPPAPAPARDEL---PDWNEVLPPWDREEDEV 537
P+PT P P AP + PD E L +++ +++
Sbjct: 450 PNPSPT--LRPVETPVVGAPGMGSVSTEPDDEEGLKHLEQQAEKM 492
>gi|156766045 GRB10 interacting GYF protein 2 isoform a [Homo
sapiens]
Length = 1320
Score = 60.5 bits (145), Expect = 5e-09
Identities = 119/465 (25%), Positives = 174/465 (37%), Gaps = 79/465 (16%)
Query: 24 PPGRPEAQPPPLSSEHKEPVAGDAVPGPKDGSAPEVRGARNSEPQDEGELF----QGVDP 79
PP P P P + PV G G + G ++ E Q E + +D
Sbjct: 473 PP--PVPNPSPTLRPVETPVVGAPGMGSVSTEPDDEEGLKHLEQQAEKMVAYLQDSALDD 530
Query: 80 RALAAVLLQALDRPASPPA------------PSGSQQGP--EEEAAE---------ALLT 116
LA+ L + + S P P G QGP +E AE +LL
Sbjct: 531 ERLASKLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLV 590
Query: 117 ETVRSQTHSL---------PAPESPEPAAPPRPQTPENGPEASDPSEELEALASLL---- 163
+ ++ P SP PA PP E E +EL AL +
Sbjct: 591 KRACDESFQPLGDIMKMWGRVPFSPGPAPPPH--MGELDQERLTRQQELTALYQMQHLQY 648
Query: 164 -QELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAP 222
Q L + QQ+ AA ++ + + + + R+ ++
Sbjct: 649 QQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQ------------QFQTLKMRISDQNI 696
Query: 223 LPPPAPSQFQARMPDSGPL---------PETHKFGEGVSSP--KTHLGEALAPLSKAYQG 271
+P S +PD+G + P + G P T G AL L + +
Sbjct: 697 IPSVTRS---VSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKA 753
Query: 272 VAAPFPKARRPESALLGGSEAGERLLQQGLA--QVEAGRRQAEATRQAAAQEERLADLAS 329
AA + RR E+ + E ER Q+ L Q E RRQ E R+ +EE
Sbjct: 754 KAAKLEQERR-EAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQE 812
Query: 330 DLLLQYLLQGGA--RQRGLGGRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAE 387
+ L + Q A RQR R QE A R R EE +ERR EE + +++EEAA+
Sbjct: 813 EALRRQREQEIALRRQREEEERQQQEEALRRLEERRREE--EERRKQEELLRKQEEEAAK 870
Query: 388 AEAEAEEAE-RARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKE 431
E EEA+ R +N L EE E++R ++E R+KE
Sbjct: 871 WAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKE 915
Score = 45.1 bits (105), Expect = 2e-04
Identities = 34/129 (26%), Positives = 62/129 (48%), Gaps = 6/129 (4%)
Query: 356 EERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGA 415
++ E R ++E E++RR EE + EEA + E E A R ++ ++E+
Sbjct: 785 QQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRL 844
Query: 416 EDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEE 475
E++R +EE RRK+ E + EE + + +E + L ++ + +
Sbjct: 845 EERRREEE---ERRKQEELLRKQEEEAAKWAREEEEAQRRLE---ENRLRMEEEAARLRH 898
Query: 476 VEEKRKRKK 484
EE+RKRK+
Sbjct: 899 EEEERKRKE 907
Score = 36.6 bits (83), Expect = 0.070
Identities = 47/225 (20%), Positives = 90/225 (40%), Gaps = 27/225 (12%)
Query: 330 DLLLQYLLQGGARQRGL---GGRGLQEAAEERESAREEEEAE----QERRGGEERVGEED 382
D L ++ L+ + G G L ++E EE+E + E + G +
Sbjct: 305 DSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVDEGEECSDSEGSHN 364
Query: 383 EEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKR-------SQEETPGHRRKEAEGT 435
EEA E + + + E + + + A EE + + R +E RK+ T
Sbjct: 365 EEAKEPD-KTNKKEGEKTDRVGVASEETPQTSSSSARPGTPSDHQSQEASQFERKDEPKT 423
Query: 436 EEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKRKRKKNAPPEPVPPPR 495
E+ + E++ M+ L K+ D++V+ +++ + +P +PPP
Sbjct: 424 EQTEKAEEETRMEN-------SLPAKVPSRGDEMVADVQQPLSQIPSDTASPLLILPPPV 476
Query: 496 AAPAPTHVRSPQPPPPAPAPARDEL---PDWNEVLPPWDREEDEV 537
P+PT P P AP + PD E L +++ +++
Sbjct: 477 PNPSPT--LRPVETPVVGAPGMGSVSTEPDDEEGLKHLEQQAEKM 519
>gi|156766043 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 60.5 bits (145), Expect = 5e-09
Identities = 119/465 (25%), Positives = 174/465 (37%), Gaps = 79/465 (16%)
Query: 24 PPGRPEAQPPPLSSEHKEPVAGDAVPGPKDGSAPEVRGARNSEPQDEGELF----QGVDP 79
PP P P P + PV G G + G ++ E Q E + +D
Sbjct: 452 PP--PVPNPSPTLRPVETPVVGAPGMGSVSTEPDDEEGLKHLEQQAEKMVAYLQDSALDD 509
Query: 80 RALAAVLLQALDRPASPPA------------PSGSQQGP--EEEAAE---------ALLT 116
LA+ L + + S P P G QGP +E AE +LL
Sbjct: 510 ERLASKLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLV 569
Query: 117 ETVRSQTHSL---------PAPESPEPAAPPRPQTPENGPEASDPSEELEALASLL---- 163
+ ++ P SP PA PP E E +EL AL +
Sbjct: 570 KRACDESFQPLGDIMKMWGRVPFSPGPAPPPH--MGELDQERLTRQQELTALYQMQHLQY 627
Query: 164 -QELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAP 222
Q L + QQ+ AA ++ + + + + R+ ++
Sbjct: 628 QQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQ------------QFQTLKMRISDQNI 675
Query: 223 LPPPAPSQFQARMPDSGPL---------PETHKFGEGVSSP--KTHLGEALAPLSKAYQG 271
+P S +PD+G + P + G P T G AL L + +
Sbjct: 676 IPSVTRS---VSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKA 732
Query: 272 VAAPFPKARRPESALLGGSEAGERLLQQGLA--QVEAGRRQAEATRQAAAQEERLADLAS 329
AA + RR E+ + E ER Q+ L Q E RRQ E R+ +EE
Sbjct: 733 KAAKLEQERR-EAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQE 791
Query: 330 DLLLQYLLQGGA--RQRGLGGRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAE 387
+ L + Q A RQR R QE A R R EE +ERR EE + +++EEAA+
Sbjct: 792 EALRRQREQEIALRRQREEEERQQQEEALRRLEERRREE--EERRKQEELLRKQEEEAAK 849
Query: 388 AEAEAEEAE-RARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKE 431
E EEA+ R +N L EE E++R ++E R+KE
Sbjct: 850 WAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKE 894
Score = 45.1 bits (105), Expect = 2e-04
Identities = 34/129 (26%), Positives = 62/129 (48%), Gaps = 6/129 (4%)
Query: 356 EERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGA 415
++ E R ++E E++RR EE + EEA + E E A R ++ ++E+
Sbjct: 764 QQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRL 823
Query: 416 EDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEE 475
E++R +EE RRK+ E + EE + + +E + L ++ + +
Sbjct: 824 EERRREEE---ERRKQEELLRKQEEEAAKWAREEEEAQRRLE---ENRLRMEEEAARLRH 877
Query: 476 VEEKRKRKK 484
EE+RKRK+
Sbjct: 878 EEEERKRKE 886
Score = 37.0 bits (84), Expect = 0.054
Identities = 47/225 (20%), Positives = 88/225 (39%), Gaps = 26/225 (11%)
Query: 330 DLLLQYLLQGGARQRGL---GGRGLQEAAEERESAREEEEAE----QERRGGEERVGEED 382
D L ++ L+ + G G L ++E EE+E + E + G +
Sbjct: 283 DSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVDEGEECSDSEGSHN 342
Query: 383 EEAAEAE-AEAEEAERARQNALLFAEE------EDGEAGAEDKRSQEETPGHRRKEAEGT 435
EEA E + +E E+ + + +EE G +E RK+ T
Sbjct: 343 EEAKEPDKTNKKEGEKTDRVGVEASEETPQTSSSSARPGTPSDHQSQEASQFERKDEPKT 402
Query: 436 EEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKRKRKKNAPPEPVPPPR 495
E+ + E++ M+ L K+ D++V+ +++ + +P +PPP
Sbjct: 403 EQTEKAEEETRMENS-------LPAKVPSRGDEMVADVQQPLSQIPSDTASPLLILPPPV 455
Query: 496 AAPAPTHVRSPQPPPPAPAPARDEL---PDWNEVLPPWDREEDEV 537
P+PT P P AP + PD E L +++ +++
Sbjct: 456 PNPSPT--LRPVETPVVGAPGMGSVSTEPDDEEGLKHLEQQAEKM 498
>gi|42476299 GRB10 interacting GYF protein 2 isoform b [Homo
sapiens]
Length = 1299
Score = 60.5 bits (145), Expect = 5e-09
Identities = 119/465 (25%), Positives = 174/465 (37%), Gaps = 79/465 (16%)
Query: 24 PPGRPEAQPPPLSSEHKEPVAGDAVPGPKDGSAPEVRGARNSEPQDEGELF----QGVDP 79
PP P P P + PV G G + G ++ E Q E + +D
Sbjct: 452 PP--PVPNPSPTLRPVETPVVGAPGMGSVSTEPDDEEGLKHLEQQAEKMVAYLQDSALDD 509
Query: 80 RALAAVLLQALDRPASPPA------------PSGSQQGP--EEEAAE---------ALLT 116
LA+ L + + S P P G QGP +E AE +LL
Sbjct: 510 ERLASKLQEHRAKGVSIPLMHEAMQKWYYKDPQGEIQGPFNNQEMAEWFQAGYFTMSLLV 569
Query: 117 ETVRSQTHSL---------PAPESPEPAAPPRPQTPENGPEASDPSEELEALASLL---- 163
+ ++ P SP PA PP E E +EL AL +
Sbjct: 570 KRACDESFQPLGDIMKMWGRVPFSPGPAPPPH--MGELDQERLTRQQELTALYQMQHLQY 627
Query: 164 -QELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAP 222
Q L + QQ+ AA ++ + + + + R+ ++
Sbjct: 628 QQFLIQQQYAQVLAQQQKAALSSQQQQQLALLLQ------------QFQTLKMRISDQNI 675
Query: 223 LPPPAPSQFQARMPDSGPL---------PETHKFGEGVSSP--KTHLGEALAPLSKAYQG 271
+P S +PD+G + P + G P T G AL L + +
Sbjct: 676 IPSVTRS---VSVPDTGSIWELQPTASQPTVWEGGSVWDLPLDTTTPGPALEQLQQLEKA 732
Query: 272 VAAPFPKARRPESALLGGSEAGERLLQQGLA--QVEAGRRQAEATRQAAAQEERLADLAS 329
AA + RR E+ + E ER Q+ L Q E RRQ E R+ +EE
Sbjct: 733 KAAKLEQERR-EAEMRAKREEEERKRQEELRRQQEEILRRQQEEERKRREEEELARRKQE 791
Query: 330 DLLLQYLLQGGA--RQRGLGGRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAE 387
+ L + Q A RQR R QE A R R EE +ERR EE + +++EEAA+
Sbjct: 792 EALRRQREQEIALRRQREEEERQQQEEALRRLEERRREE--EERRKQEELLRKQEEEAAK 849
Query: 388 AEAEAEEAE-RARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKE 431
E EEA+ R +N L EE E++R ++E R+KE
Sbjct: 850 WAREEEEAQRRLEENRLRMEEEAARLRHEEEERKRKELEVQRQKE 894
Score = 45.1 bits (105), Expect = 2e-04
Identities = 34/129 (26%), Positives = 62/129 (48%), Gaps = 6/129 (4%)
Query: 356 EERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGA 415
++ E R ++E E++RR EE + EEA + E E A R ++ ++E+
Sbjct: 764 QQEEILRRQQEEERKRREEEELARRKQEEALRRQREQEIALRRQREEEERQQQEEALRRL 823
Query: 416 EDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEE 475
E++R +EE RRK+ E + EE + + +E + L ++ + +
Sbjct: 824 EERRREEE---ERRKQEELLRKQEEEAAKWAREEEEAQRRLE---ENRLRMEEEAARLRH 877
Query: 476 VEEKRKRKK 484
EE+RKRK+
Sbjct: 878 EEEERKRKE 886
Score = 37.0 bits (84), Expect = 0.054
Identities = 47/225 (20%), Positives = 88/225 (39%), Gaps = 26/225 (11%)
Query: 330 DLLLQYLLQGGARQRGL---GGRGLQEAAEERESAREEEEAE----QERRGGEERVGEED 382
D L ++ L+ + G G L ++E EE+E + E + G +
Sbjct: 283 DSLPEWCLEDAEEEMGTFDSSGAFLSLKKVQKEPIPEEQEMDFRPVDEGEECSDSEGSHN 342
Query: 383 EEAAEAE-AEAEEAERARQNALLFAEE------EDGEAGAEDKRSQEETPGHRRKEAEGT 435
EEA E + +E E+ + + +EE G +E RK+ T
Sbjct: 343 EEAKEPDKTNKKEGEKTDRVGVEASEETPQTSSSSARPGTPSDHQSQEASQFERKDEPKT 402
Query: 436 EEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKRKRKKNAPPEPVPPPR 495
E+ + E++ M+ L K+ D++V+ +++ + +P +PPP
Sbjct: 403 EQTEKAEEETRMENS-------LPAKVPSRGDEMVADVQQPLSQIPSDTASPLLILPPPV 455
Query: 496 AAPAPTHVRSPQPPPPAPAPARDEL---PDWNEVLPPWDREEDEV 537
P+PT P P AP + PD E L +++ +++
Sbjct: 456 PNPSPT--LRPVETPVVGAPGMGSVSTEPDDEEGLKHLEQQAEKM 498
>gi|7662302 TBK1 binding protein 1 [Homo sapiens]
Length = 615
Score = 58.5 bits (140), Expect = 2e-08
Identities = 85/340 (25%), Positives = 123/340 (36%), Gaps = 53/340 (15%)
Query: 294 ERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLA--------------SDLLLQYL-LQ 338
E L++ A VE RQ Q Q++ L D A +DL L YL L+
Sbjct: 145 ETELREMRALVETHLRQICGLEQQLRQQQGLQDAAFSNLSPPPAPAPPCTDLDLHYLALR 204
Query: 339 GGARQRGLGGRGLQEAAEERESAREEEE---AEQERRGGEERVGEEDEEAAEAEAEAEEA 395
GG+ G G + + E R EE A+ E RG + R + E + E ++
Sbjct: 205 GGSGLSHAGWPGSTPSVSDLERRRLEEALEAAQGEARGAQLREEQLQAECERLQGELKQL 264
Query: 396 ERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSL 455
+ R L + E A KR ++ E TEE G + + + + +L
Sbjct: 265 QETRAQDLASNQSERDMAWV--KRVGDDQVNLALAYTELTEELGRLRELSSLQGRILRTL 322
Query: 456 IELSTKLHLPADDVVSIIEEVEEKRKRKKNAP--PEPVPPPRAAPAPTHVRSP-----QP 508
++ + +S +R AP P P PP RAAP +SP P
Sbjct: 323 LQEQARSGGQRHSPLS---------QRHSPAPQCPSPSPPARAAPPCPPCQSPVPQRRSP 373
Query: 509 PPPAPAPARDELPDWNEVLPPWDREEDEVYPPGPYHPFPN------------YIRPRTLQ 556
PP P+P + P P + V PP P P RP
Sbjct: 374 VPPCPSPQQRRSPASPSCPSPVPQRRSPV-PPSCQSPSPQRRSPVPPSCPAPQPRPPPPP 432
Query: 557 PPSALRRRHYHHALPPSRH----YPGREAQARRAQEEAEA 592
PP +A PPS H + GR + + A+ A A
Sbjct: 433 PPGERTLAERAYAKPPSHHVKAGFQGRRSYSELAEGAAYA 472
Score = 34.7 bits (78), Expect = 0.27
Identities = 45/191 (23%), Positives = 66/191 (34%), Gaps = 25/191 (13%)
Query: 107 EEEAAEALLTETVRSQTHS----LPAPESPEPAAPPRPQTPENGPEASDPSEELEALASL 162
+E+A + SQ HS P+P P AAPP P P+ P
Sbjct: 324 QEQARSGGQRHSPLSQRHSPAPQCPSPSPPARAAPPCPPCQSPVPQRRSPVPPCP----- 378
Query: 163 LQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAP 222
SP + + + + + +SP P+ R S P+ P
Sbjct: 379 -------SPQQRRSPASPSCPSPVPQRRSPVPPSCQSPSPQ---RRSPVPPSCPAPQPRP 428
Query: 223 LPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHL----GEALAPLSKAY-QGVAAPFP 277
PPP P + + + P +H G +++ G A A S + Q AA P
Sbjct: 429 PPPPPPGE-RTLAERAYAKPPSHHVKAGFQGRRSYSELAEGAAYAGASPPWLQAEAATLP 487
Query: 278 KARRPESALLG 288
K R S L G
Sbjct: 488 KPRAYGSELYG 498
Score = 30.8 bits (68), Expect = 3.8
Identities = 55/231 (23%), Positives = 81/231 (35%), Gaps = 32/231 (13%)
Query: 34 PLSSEHKEPVAGDAVPGPKDGSAPEVRGARNSEPQDEGELFQGVDPRALAAVLLQALDRP 93
PLS H P P P +AP ++ PQ + P Q P
Sbjct: 336 PLSQRHS-PAPQCPSPSPPARAAPPCPPCQSPVPQRRSPVPPCPSP--------QQRRSP 386
Query: 94 ASP--PAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESP-EPAAPPRPQTPENGPEAS 150
ASP P+P ++ P + ++ + S PAP+ P PP +T A
Sbjct: 387 ASPSCPSPVPQRRSPVPPSCQSPSPQRRSPVPPSCPAPQPRPPPPPPPGERTLAERAYAK 446
Query: 151 DPSEELEA------LASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPG--- 201
PS ++A S L E ++ +S Q AA + R + L PG
Sbjct: 447 PPSHHVKAGFQGRRSYSELAEGAAYAGASPPWLQAEAATLPKPRAY---GSELYGPGRPL 503
Query: 202 -PERVWRASWGEFQARVPER----APLPPPAPSQFQARMPD---SGPLPET 244
P R + F+ + E P PP+P R P+PE+
Sbjct: 504 SPRRAFEGIRLRFEKQPSEEDEWAVPTSPPSPEVGTIRCASFCAGFPIPES 554
>gi|88196790 coiled-coil domain containing 88 [Homo sapiens]
Length = 1476
Score = 58.2 bits (139), Expect = 2e-08
Identities = 124/529 (23%), Positives = 199/529 (37%), Gaps = 76/529 (14%)
Query: 17 INGLGAAPPGRPEAQPPPLSSEHKEPVAGDAVPGPKDGSAPEVRGARNSEPQ-------D 69
+ GL G+P Q P L + ++PV P AP+ A + PQ D
Sbjct: 471 LRGLLQVLQGQPGGQHPLLEAPREDPVL------PVLEEAPQTPVAFDHSPQGLVQKARD 524
Query: 70 EGELFQGVDPRALAAVLLQALDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAP 129
G + P AL +VL + + P +P + + P + AA Q P
Sbjct: 525 GGPQALDLAPPALDSVLEASAECPQAPDSDPQEAESPLQAAAMDPQASDWSPQESGSPVE 584
Query: 130 --ESPEPAAPPRP-QTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQETAAAETE 186
ESPE A Q+P + P +++A L E + E E
Sbjct: 585 TQESPEKAGRRSSLQSPASVAPPQGPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQE 644
Query: 187 TRTHTL-----TRVNLESP-GPERVWRASWGEFQARVPER---APLPPPAPSQFQARMPD 237
H + V LE GP + + G+ +AR ++ + PA + Q +
Sbjct: 645 GPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEG 704
Query: 238 S-------GPLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFP-KARRPESALLGG 289
+ GP+P GV+ + L E +A L + + + +AR+ E+
Sbjct: 705 ALEVQVWEGPIPG-ESLASGVAEQEA-LREEVAQLRRKAEALGDELEAQARKLEAQNTEA 762
Query: 290 SEAGERLLQQGLAQVEAGRR-QAEATRQA--------AAQEERLADLASDLLLQYLLQGG 340
+ + L Q A+ EA R +A+A QA A QE A + L++ L G
Sbjct: 763 ARLSKELAQARRAEAEAHREAEAQAWEQARLREAVEAAGQELESASQEREALVEALAAAG 822
Query: 341 ARQR-----GLGGRGLQEAAEER------ESAREEEEAEQERRGGEERVGEEDEEAAEAE 389
+R G R EAAEER E + EEAE+ERR ++EA +AE
Sbjct: 823 RERRQWEREGSRLRAQSEAAEERMQVLESEGRQHLEEAERERR---------EKEALQAE 873
Query: 390 AEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDP 449
E A L + + E A +++ + + +G E+ E E
Sbjct: 874 LEKAVVRGKELGARLEHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATS 933
Query: 450 QTIDSLIELSTKLHLPADDVVSIIEEVEEKRKRKKNAPPEPVPPPRAAP 498
+ ++L+EL T+ ++EE+ + + P P RA P
Sbjct: 934 KE-EALMELKTR-----------ALQLEEELFQLRQGPAGLGPKKRAEP 970
Score = 54.7 bits (130), Expect = 2e-07
Identities = 115/456 (25%), Positives = 167/456 (36%), Gaps = 66/456 (14%)
Query: 23 APPGRPEAQPPPLSSEHKEPVAGDAVPGPKDGS------APEVRGARNS--------EPQ 68
AP P+ PL + +P A D P + GS +PE G R+S PQ
Sbjct: 550 APDSDPQEAESPLQAAAMDPQASDWSP-QESGSPVETQESPEKAGRRSSLQSPASVAPPQ 608
Query: 69 DEGELFQGVDPRALAAVLLQALDRPASPPAPSGSQQGPEEEAAEA--------------- 113
G Q +A P A Q+GPE + +
Sbjct: 609 GPGTKIQAPQLLGGETEGREAPQGELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQ 668
Query: 114 ---LLTETVRSQTHSLPAPESPEPAAPPRPQTPENGP------EASDPSEELEALASLLQ 164
L T ++ H + A +PQ G E P E L + + +
Sbjct: 669 GLDLATGQAEAREHDQRLEGTVRDPAWQKPQQKSEGALEVQVWEGPIPGESLASGVAEQE 728
Query: 165 ELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPE-RAPL 223
LR+ + +R+ E E E + L N E+ R S QAR E A
Sbjct: 729 ALRE-EVAQLRRKAEALGDELEAQARKLEAQNTEAA------RLSKELAQARRAEAEAHR 781
Query: 224 PPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPE 283
A + QAR+ ++ + + E S + L EALA + + + R
Sbjct: 782 EAEAQAWEQARLREA--VEAAGQELESASQEREALVEALAAAGRERR-------QWEREG 832
Query: 284 SALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQ 343
S L SEA E +Q + + E + EA R+ +E A+L ++ L GAR
Sbjct: 833 SRLRAQSEAAEERMQ--VLESEGRQHLEEAERERREKEALQAELEKAVVRGKEL--GARL 888
Query: 344 RGLGGRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEA--EEAERARQN 401
L Q A E +E RE+E Q +G E+R+ E + AA ++ EA E RA Q
Sbjct: 889 EHLQRELEQAALERQEFLREKESQHQRYQGLEQRLEAELQAAATSKEEALMELKTRALQL 948
Query: 402 ALLFAEEEDGEAGAEDKRSQE----ETPGHRRKEAE 433
+ G AG K+ E ET R E E
Sbjct: 949 EEELFQLRQGPAGLGPKKRAEPQLVETQNVRLIEVE 984
Score = 41.6 bits (96), Expect = 0.002
Identities = 106/441 (24%), Positives = 168/441 (38%), Gaps = 71/441 (16%)
Query: 24 PPGRPEAQP-----PPLSSEHKEPVAGDAVPGPKDGSAPEVRG---ARNSEPQDEGELFQ 75
PPG P P P L E +E AG ++ E+RG +P + L +
Sbjct: 433 PPGSPGEAPLAGAAPSLQDEVREAEAGRLRTLERENR--ELRGLLQVLQGQPGGQHPLLE 490
Query: 76 GVDPRALAAVLLQALDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPA 135
+ VL +A P +P A S QG ++A + ++ + PA +S A
Sbjct: 491 APREDPVLPVLEEA---PQTPVAFDHSPQGLVQKARDG----GPQALDLAPPALDSVLEA 543
Query: 136 APPRPQTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRV 195
+ PQ P++ P+ ++ L+A A++ + D+SP Q+ + ET+
Sbjct: 544 SAECPQAPDSDPQEAE--SPLQA-AAMDPQASDWSP-----QESGSPVETQE-------- 587
Query: 196 NLESPGPERVWRASWGEFQARVPERAPLPPPAP-SQFQARMPDSGPLPETHKFGEGVSSP 254
PE+ R S + A V PP P ++ QA G ET EG +P
Sbjct: 588 -----SPEKAGRRSSLQSPASVA-----PPQGPGTKIQAPQLLGG---ET----EGREAP 630
Query: 255 KTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEA---GRRQA 311
+ GE + Q P P S L E + L Q EA +R
Sbjct: 631 Q---GELVPEAWGLRQEGPEHKPGPSEPSSVQLEEQEGPNQGLDLATGQAEAREHDQRLE 687
Query: 312 EATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEERESAREEEEAEQER 371
R A Q+ + S+ L+ + G + G L E+E+ REE A+ R
Sbjct: 688 GTVRDPAWQKPQQK---SEGALEVQVWEGP----IPGESLASGVAEQEALREEV-AQLRR 739
Query: 372 RGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKE 431
+ E +G+E EA+A EA+ L + A AE R E + +
Sbjct: 740 KA--EALGDE----LEAQARKLEAQNTEAARLSKELAQARRAEAEAHREAEAQAWEQARL 793
Query: 432 AEGTEEGGEEEDDEEMDPQTI 452
E E G+E + + + +
Sbjct: 794 REAVEAAGQELESASQEREAL 814
Score = 35.0 bits (79), Expect = 0.20
Identities = 60/234 (25%), Positives = 88/234 (37%), Gaps = 30/234 (12%)
Query: 277 PKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYL 336
P RPE+ +E L LA +A R+ + A E L D +++
Sbjct: 236 PLCLRPEAPSRAPAEGPSHHLALQLANAKAQLRRLRQELEEKA--ELLLDSQAEV---QG 290
Query: 337 LQGGARQRGLGGRGLQEAAEERESAREEEEAEQERRGGEERVGEEDE------EAAEAEA 390
L+ R+ + L A+ E REE EA +ER G R+ EE +AAEA
Sbjct: 291 LEAEIRRLRQEAQALSGQAKRAELYREEAEALRERAGRLPRLQEELRRCRERLQAAEAYK 350
Query: 391 EAEEAERARQNALLFAE---EEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEM 447
E ER L ++ EE EA E ET +R+ GE + +
Sbjct: 351 SQLEEERVLSGVLEASKALLEEQLEAARERCARLHET---QRENLLLRTRLGEAHAELDS 407
Query: 448 DPQTIDSLIELSTKLHLPADDVVSIIEEVEEKRKRKKNAPPEPVPPPRAAPAPT 501
+D L E + +L L E ++ + P P P A AP+
Sbjct: 408 LRHQVDQLAEENVELEL-------------ELQRSLEPPPGSPGEAPLAGAAPS 448
>gi|39930517 sterile alpha motif domain containing 1 [Homo sapiens]
Length = 538
Score = 58.2 bits (139), Expect = 2e-08
Identities = 115/447 (25%), Positives = 152/447 (34%), Gaps = 87/447 (19%)
Query: 84 AVLLQALDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPPRPQTP 143
A +Q R A+PPAP + +G AA A P P P P AP P
Sbjct: 96 AARVQPPRRGATPPAPPRAPRGAPAAAAAAAPP----------PTPAPPPPPAPVAAAAP 145
Query: 144 ENGPEASDPSEELEALASLLQELRDFSPSSAK---RQQETAAAETETRTHTLTRVNLESP 200
P A+ + SP A+ R Q A
Sbjct: 146 ARAPRAAAAAATAPP-----------SPGPAQPGPRAQRAAPLAAPPPAPAAPPAVAPPA 194
Query: 201 GPERVWRASWGEFQARVPERAPLP-PPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLG 259
GP R A AR P P P PPAP Q Q P P P+ G V + G
Sbjct: 195 GPRR---APPPAVAAREPPLPPPPQPPAPPQQQQPPP---PQPQPPPEGGAVRA-----G 243
Query: 260 EALAPLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAA 319
A P+S R LGGS L +G Q G + EA +
Sbjct: 244 GAARPVSL-------------REVVRYLGGSGGAGGRLTRGRVQ---GLLEEEAAARGRL 287
Query: 320 QEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEERESAREEEEAEQERRGGEERVG 379
+ RL LA L G R GR AA R S + +RGGEERV
Sbjct: 288 ERTRLGALA--------LPRGDRP----GRA-PPAASARPS--------RSKRGGEERVL 326
Query: 380 EEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKE--AEGTEE 437
E++EE + E E EE + + + + E D AGA+ + E KE E T
Sbjct: 327 EKEEEEDDDEDEDEEDDVSEGSEV---PESDRPAGAQHHQLNGERGPQSAKERVKEWTPC 383
Query: 438 GGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKRKRKKNAPPEPVPPPRAA 497
G + DE P ++ + + + + + + P PVP P
Sbjct: 384 GPHQGQDEGRGPAPGSGTRQVFSMAAMNKEGGTASVATGPDS--------PSPVPLPPGK 435
Query: 498 PA-PTHVRSPQPPPPAPAPARDELPDW 523
PA P +P PP + +W
Sbjct: 436 PALPGADGTPFGCPPGRKEKPSDPVEW 462
Score = 47.0 bits (110), Expect = 5e-05
Identities = 45/137 (32%), Positives = 53/137 (38%), Gaps = 29/137 (21%)
Query: 22 AAPPGRPEAQPPPLSSEHKEPVAGDAVPGPKDGSAPEVRGARNSEPQDEGELFQGVDPRA 81
AAPP P PPP PVA A AP A + P G G PRA
Sbjct: 125 AAPPPTPAPPPPP------APVAAAA-----PARAPRAAAAAATAPPSPGPAQPG--PRA 171
Query: 82 -LAAVLLQALDRPASPPA---PSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAP 137
AA L PA+PPA P+G ++ P A P P P+P AP
Sbjct: 172 QRAAPLAAPPPAPAAPPAVAPPAGPRRAPPPAVA-----------AREPPLPPPPQPPAP 220
Query: 138 PRPQTPENGPEASDPSE 154
P+ Q P P+ P E
Sbjct: 221 PQQQQPP-PPQPQPPPE 236
Score = 39.7 bits (91), Expect = 0.008
Identities = 32/112 (28%), Positives = 40/112 (35%), Gaps = 9/112 (8%)
Query: 452 IDSLIELSTKLHLPADDVVSIIEEVEEKRKRKKNAPPEPVPPPRAAPAPTHVRSPQP--- 508
++ LI+ L + +S + R+ PP P PR APA +P P
Sbjct: 73 LEKLIQQRAVLRVSYKGSISYRNAARVQPPRRGATPPAPPRAPRGAPAAAAAAAPPPTPA 132
Query: 509 PPPAPAPARDELPDWNEVLPPWDREEDEVYP--PGPYHPFPNYIRPRTLQPP 558
PPP PAP P P P PGP P P R L P
Sbjct: 133 PPPPPAPVAAAAP----ARAPRAAAAAATAPPSPGPAQPGPRAQRAAPLAAP 180
Score = 34.7 bits (78), Expect = 0.27
Identities = 35/115 (30%), Positives = 40/115 (34%), Gaps = 15/115 (13%)
Query: 487 PPEPVPPPRAAP--------APTHVRSPQPPPPAPAPA----RDELPDWNEVLPPWDREE 534
PP P PPP AP AP + PP+P PA R + PP
Sbjct: 128 PPTPAPPPPPAPVAAAAPARAPRAAAAAATAPPSPGPAQPGPRAQRAAPLAAPPPAPAAP 187
Query: 535 DEVYPP-GPYHPFPNYIRPR--TLQPPSALRRRHYHHALPPSRHYPGREAQARRA 586
V PP GP P + R L PP PP + P E A RA
Sbjct: 188 PAVAPPAGPRRAPPPAVAAREPPLPPPPQPPAPPQQQQPPPPQPQPPPEGGAVRA 242
Score = 33.9 bits (76), Expect = 0.45
Identities = 39/139 (28%), Positives = 51/139 (36%), Gaps = 20/139 (14%)
Query: 23 APPGRPEAQPPPLSSEHKEPVAGDAVPGPKDGSAPEVRGARNSEPQDEGELFQGVDPRAL 82
APP P PPP + + P+ P P+ + P+ + +PQ E G RA
Sbjct: 191 APPAGPRRAPPPAVAAREPPLP----PPPQPPAPPQQQQPPPPQPQPPPE---GGAVRAG 243
Query: 83 AAVLLQALDRPASPPAPSGSQQGP----------EEEAAEALLTETVRSQTHSLPAPESP 132
A +L SG G EEEAA E R +LP + P
Sbjct: 244 GAARPVSLREVVRYLGGSGGAGGRLTRGRVQGLLEEEAAARGRLERTRLGALALPRGDRP 303
Query: 133 ---EPAAPPRPQTPENGPE 148
PAA RP + G E
Sbjct: 304 GRAPPAASARPSRSKRGGE 322
Score = 32.0 bits (71), Expect = 1.7
Identities = 24/66 (36%), Positives = 28/66 (42%), Gaps = 3/66 (4%)
Query: 482 RKKNAPPEPVPPPRAAPAPTHVRSPQPP--PPAPAPARDELPDWNEVLPPWDREEDEVYP 539
R + A P PPP A AP V P P P PA A E P PP ++ + P
Sbjct: 170 RAQRAAPLAAPPPAPA-APPAVAPPAGPRRAPPPAVAAREPPLPPPPQPPAPPQQQQPPP 228
Query: 540 PGPYHP 545
P P P
Sbjct: 229 PQPQPP 234
Score = 30.0 bits (66), Expect = 6.5
Identities = 26/77 (33%), Positives = 29/77 (37%), Gaps = 11/77 (14%)
Query: 486 APPEPVPPPRAAPAPTHVRSPQ---PPPPAPAPARDELPDW-NEVLPPWDREEDEVYPPG 541
APP P P A P P R+ PPP AP P PP + PP
Sbjct: 158 APPSPGP---AQPGPRAQRAAPLAAPPPAPAAPPAVAPPAGPRRAPPPAVAAREPPLPPP 214
Query: 542 PYHPFPNYIRPRTLQPP 558
P P P P+ QPP
Sbjct: 215 PQPPAP----PQQQQPP 227
>gi|41322923 plectin 1 isoform 11 [Homo sapiens]
Length = 4547
Score = 56.6 bits (135), Expect = 7e-08
Identities = 98/371 (26%), Positives = 152/371 (40%), Gaps = 43/371 (11%)
Query: 149 ASDPSEELEALASLLQELRDFSPSS--AKRQQETAAAETETRTHTLTRV-NLESPGPERV 205
A D ++ ++ LQ+LR S + AK +Q AA + R RV L+ ER
Sbjct: 1408 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1467
Query: 206 WRASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPL 265
+ GE QA RA + QA+ E + V +A L
Sbjct: 1468 RGGAEGELQAL---RARAEEAEAQKRQAQ-------EEAERLRRQVQDESQRKRQAEVEL 1517
Query: 266 SKAYQGVAAPFPKARRPESAL----LGGSEAGERLLQQGLAQVEAGRRQAEA--TRQAAA 319
+ + A + +R AL L EA RL Q A+VE R+ A T Q +A
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ---AEVERARQVQVALETAQRSA 1574
Query: 320 QEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEER-----ESAREEEEAEQERRGG 374
+ E + AS L+ ++ + L+E AE R E+ R EEAE+E
Sbjct: 1575 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL--- 1631
Query: 375 EERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEG 434
ER + EA +AEE A+Q +L AE AE ++ + E RR +AE
Sbjct: 1632 -ERWQLKANEALRLRLQAEEV--AQQKSLAQAE-------AEKQKEEAEREARRRGKAEE 1681
Query: 435 TEEGGEEEDDEEMDPQTIDSLIELSTKLHLPAD-DVVSIIEEVEEKRKRKKNAPPEPVPP 493
E ++E++ Q L E + + L A+ +++ + E E+ ++++ E
Sbjct: 1682 QAVRQRELAEQELEKQR--QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1739
Query: 494 PRAAPAPTHVR 504
R A A T R
Sbjct: 1740 QREAAAATQKR 1750
Score = 50.1 bits (118), Expect = 6e-06
Identities = 105/397 (26%), Positives = 149/397 (37%), Gaps = 67/397 (16%)
Query: 87 LQALDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPP-----RPQ 141
LQ L + + + ++Q E + + E +R L A E A R +
Sbjct: 1422 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1481
Query: 142 TPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQET-----------AAAETETRTH 190
E + EE E L +Q+ S KRQ E AA E +
Sbjct: 1482 AEEAEAQKRQAQEEAERLRRQVQD-----ESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536
Query: 191 TLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEG 250
L + L++ ER R QA V ERA A Q R ++ + F E
Sbjct: 1537 ALEELRLQAEEAERRLR------QAEV-ERARQVQVALETAQ-RSAEAELQSKRASFAEK 1588
Query: 251 VSSPKTHLGE---ALAPLSKAYQGVAAPFPKARRPES---------------ALLGGSEA 292
+ + L E A+A L + + A +A R AL +A
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1648
Query: 293 GERLLQQGLAQVEAGRRQAEATRQAA--AQEERLADLASDLLLQYLLQGGARQRGLG-GR 349
E Q+ LAQ EA +++ EA R+A + E A +L Q L +QR L G
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL----EKQRQLAEGT 1704
Query: 350 GLQEAAEERESAR---EEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAE------RARQ 400
Q A E+E R E E+ EQ+R+ EE + EAA A + +E E RA
Sbjct: 1705 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1764
Query: 401 NALLF----AEEEDGEAGAEDKRSQEETPGHRRKEAE 433
LL AEEE + K+ E G R+ AE
Sbjct: 1765 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801
Score = 49.3 bits (116), Expect = 1e-05
Identities = 56/198 (28%), Positives = 88/198 (44%), Gaps = 34/198 (17%)
Query: 267 KAYQGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLAD 326
+ + +AA AR+ ++AL E ERL A+VE RR E Q +A++ +LA
Sbjct: 1989 RVQKSLAAEEEAARQRKAAL----EEVERLK----AKVEEARRLRERAEQESARQLQLAQ 2040
Query: 327 LASDLLLQY---------------LLQGGARQRGLGGRGLQEAAEERESAREEEEAEQER 371
A+ LQ L Q +++ + + EA R +A E EEA
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-- 2098
Query: 372 RGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAE-EEDGEAGAEDKRSQEETPGHRRK 430
+ + EAA++ + EEAER +Q+A A+ +A AE R + E RR
Sbjct: 2099 --------QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2150
Query: 431 EAEGTEEGGEEEDDEEMD 448
+AE ++ D EM+
Sbjct: 2151 QAEQAALRQKQAADAEME 2168
Score = 48.9 bits (115), Expect = 1e-05
Identities = 81/345 (23%), Positives = 139/345 (40%), Gaps = 78/345 (22%)
Query: 295 RLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQ-YLLQGGARQRGLGGRGLQE 353
+ + + L ++E R AE +Q A + ERLA++ + L Q L + A+ + R +E
Sbjct: 1335 KFISETLRRMEEEERLAE--QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE 1392
Query: 354 AAE--ERESAREEE---EAEQERRGGEERVGE-EDEEAAEAEAEAEEAERARQNALLFAE 407
+ + E R EE +A+Q++R +E + + AE +A+A +AE A ++ L E
Sbjct: 1393 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1452
Query: 408 E-----------EDGEAGAED-----KRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQT 451
E E GAE + EE +R+ E E + DE +
Sbjct: 1453 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1512
Query: 452 IDSLIELSTKLHLPADDV------VSIIEEV----EEKRKRKKNAPPEPVPPPRAAPAPT 501
+ +EL++++ A+ + +EE+ EE +R + A E RA
Sbjct: 1513 AE--VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE-----RARQVQV 1565
Query: 502 HVRSPQPPPPAPAPARDELPDWNEVLPPWDREEDEVYPPGPYHPFPNYIRPRTLQPPSAL 561
+ + Q A A + + + E +T Q +L
Sbjct: 1566 ALETAQRS--AEAELQSKRASFAE---------------------------KTAQLERSL 1596
Query: 562 RRRHYHHALPPSRHYPGREAQARRAQEEAEAEERRLQEQEELENY 606
+ H A RE RRAQ++AEAE R + + ELE +
Sbjct: 1597 QEEHVAVAQL-------REEAERRAQQQAEAERAREEAERELERW 1634
Score = 47.8 bits (112), Expect = 3e-05
Identities = 86/398 (21%), Positives = 145/398 (36%), Gaps = 26/398 (6%)
Query: 90 LDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEA 149
L+ ASP Q G E E + T S+ +L + + R E
Sbjct: 1293 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1352
Query: 150 SDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWRAS 209
+EE E LA + L + Q A AE E + L+ E V R
Sbjct: 1353 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK-------ELQQRMQEEVVRRE 1405
Query: 210 WGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAY 269
A+ +R+ Q R + + E + + E + +
Sbjct: 1406 EAAVDAQQQKRSI----QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1461
Query: 270 QGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLAS 329
+ A AL +E E +Q + E RRQ + Q Q E +LAS
Sbjct: 1462 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE--VELAS 1519
Query: 330 DLLLQYLLQGGARQRGLGGRGLQEAAEERESA-REEEEAEQERRGGEERVGEEDEEAAEA 388
+ + AR++ + L+E + E A R +AE ER + E + +AEA
Sbjct: 1520 RVKAE---AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1576
Query: 389 EAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMD 448
E +++ A A + A L ++ R + E RR + + E EE + E++
Sbjct: 1577 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE----RRAQQQAEAERAREEAERELE 1632
Query: 449 PQTIDSLIELSTKLHLPADDVV---SIIEEVEEKRKRK 483
+ + + +L L A++V S+ + EK+K +
Sbjct: 1633 RWQLKA--NEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1668
Score = 47.8 bits (112), Expect = 3e-05
Identities = 100/423 (23%), Positives = 158/423 (37%), Gaps = 48/423 (11%)
Query: 53 DGSAPEVRGARNSEPQDEGELFQGVDPRALAAVLLQALDRPASPPAPSGSQQGPEEEAA- 111
+G+A + A + E QG R L L L R A+ A + +Q E E A
Sbjct: 1702 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA--AATQKRQELEAELAK 1759
Query: 112 -----EALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQEL 166
E LL R++ S E + E ++ + L ALA +
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQ 1816
Query: 167 RDFSPSSAKRQ---------QETAAAETETRTHTLTRVNLESPGPE--RVWRASWGE-FQ 214
R + A RQ ++ AA TR T + L+ E R+ R + E FQ
Sbjct: 1817 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1876
Query: 215 ARVPERAPLPPPAPSQ---FQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQG 271
R E A + Q R L E + + E + L +++
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1936
Query: 272 VAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDL 331
AA + + +E R +Q A++EA R+ RQ AA+EER A +
Sbjct: 1937 AAAGKAELELELGRIRSNAEDTLRSKEQ--AELEAARQ-----RQLAAEEERRRREAEER 1989
Query: 332 LLQYLL--QGGARQRGLGGRGLQEAAEERESAREEEEAEQERRGGEE--RVGEEDEEAAE 387
+ + L + ARQR L+E ER A+ EE R +E R + +EAA+
Sbjct: 1990 VQKSLAAEEEAARQRKAA---LEEV--ERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2044
Query: 388 AEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEM 447
+AEE A FA ++ + + + ++ R EAE EE ++ +
Sbjct: 2045 KRLQAEEKAHA------FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2098
Query: 448 DPQ 450
+
Sbjct: 2099 QAE 2101
Score = 46.6 bits (109), Expect = 7e-05
Identities = 63/249 (25%), Positives = 103/249 (41%), Gaps = 36/249 (14%)
Query: 174 AKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQA 233
A RQ++ AA E R ERV ++ E +A +A L + +A
Sbjct: 1969 AARQRQLAAEEERRRREA----------EERVQKSLAAEEEAARQRKAALEEV--ERLKA 2016
Query: 234 RMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAG 293
++ ++ L E E S+ + L + A + A F ++ E L +
Sbjct: 2017 KVEEARRLRER---AEQESARQLQLAQEAAQKRLQAEEKAHAFA-VQQKEQELQQTLQQE 2072
Query: 294 ERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQE 353
+ +L Q + EA RR AE +A Q ER A A+ R R ++E
Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAEEARVQAEREA---------------AQSR----RQVEE 2113
Query: 354 AAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEA 413
A ++SA E+ +A + + E++ +E E+ A A+AE+A RQ AE E +
Sbjct: 2114 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA-ALRQKQAADAEMEKHKK 2172
Query: 414 GAEDKRSQE 422
AE Q+
Sbjct: 2173 FAEQTLRQK 2181
Score = 41.6 bits (96), Expect = 0.002
Identities = 54/168 (32%), Positives = 75/168 (44%), Gaps = 15/168 (8%)
Query: 278 KARRPESALLGGSEAGERLLQQGLAQVEAGRR-QAEATRQAAAQEERLADLASDLLLQYL 336
KA+ E+ L E Q LAQ A +R QAE A A +++ +L L +
Sbjct: 2015 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074
Query: 337 LQGGARQRGLGGRGLQEAAEERESAR--EEEEAEQERRGGEE-----RVGEEDEEA-AEA 388
+ R R AAEE E AR E EA Q RR EE + EE +A A+A
Sbjct: 2075 VLDQLRGEAEAAR---RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2131
Query: 389 EAEAEEAER-ARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGT 435
+A AE+ + A Q A A+ E +A K++ + +K AE T
Sbjct: 2132 QAAAEKLRKEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQT 2177
Score = 38.5 bits (88), Expect = 0.018
Identities = 84/370 (22%), Positives = 140/370 (37%), Gaps = 56/370 (15%)
Query: 149 ASDPSEELEA-LASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWR 207
A+ +ELEA LA + E+ S A+ ++E+ + +++
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL---------------E 1790
Query: 208 ASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPK-THLGEALAPLS 266
A G F+ E A L A + R E V + K +GEA +
Sbjct: 1791 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1850
Query: 267 KAYQGVAAPFPKARRPESALLGGSEAGERL-LQQGLAQVEAG--RRQAEATRQAAAQEER 323
+A +A +A L EA +R L++ AQ +A R A+ + + ++ ER
Sbjct: 1851 EAE--IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1908
Query: 324 LADLASDLLLQ-------YLLQGGARQRGLGGRG--------LQEAAEERESAREEEEAE 368
L D L Q L + ++ G+ ++ AE+ ++E+ E E
Sbjct: 1909 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 1968
Query: 369 QERR----GGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAED-----KR 419
R+ EER E EE + AEE E ARQ E E +A E+ +R
Sbjct: 1969 AARQRQLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKVEEARRLRER 2027
Query: 420 SQEET---------PGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVV 470
+++E+ +R +AE + E+ QT+ + +L A+
Sbjct: 2028 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2087
Query: 471 SIIEEVEEKR 480
EE EE R
Sbjct: 2088 RAAEEAEEAR 2097
Score = 38.1 bits (87), Expect = 0.024
Identities = 71/289 (24%), Positives = 115/289 (39%), Gaps = 33/289 (11%)
Query: 148 EASDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWR 207
+A + L+A A LLQ+ ++ + A+R QE + E L E+ G +R
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQE----DKEQMAQQLAE---ETQGFQRTLE 2369
Query: 208 ASWG---EFQARVPERAPLPPPAPSQFQARMPDSGPL--PETHKFGEGVSSPKTHLGEAL 262
A E A ER L S+ QAR + + + GE + + E +
Sbjct: 2370 AERQRQLEMSAEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2428
Query: 263 APLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQG-LAQVEAGRRQAEATRQAAAQE 321
+ A R A+ E+L Q+ L Q+++ Q Q +
Sbjct: 2429 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2488
Query: 322 ERLADL---ASDLLLQ---YLLQGGARQRGLGGRGLQEAAEERESA-REEEEAEQERRGG 374
+ L D LLQ ++ Q A+ L + +A + RE R++++ EQER
Sbjct: 2489 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER--- 2545
Query: 375 EERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEE 423
+R+ EEA + EAEE R +Q L E++ +R QEE
Sbjct: 2546 -QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ--------RRQQEE 2585
Score = 35.4 bits (80), Expect = 0.16
Identities = 85/376 (22%), Positives = 135/376 (35%), Gaps = 46/376 (12%)
Query: 243 ETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQGLA 302
E K + V + L A L K A P L G E GERL Q+
Sbjct: 1110 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR--- 1166
Query: 303 QVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQ-----EAAEE 357
G R E R ER+A L + L Q RQR L G Q E+A+
Sbjct: 1167 ---HGERDVEVER----WRERVAQLL-ERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1218
Query: 358 -----RESAREEEEAE----QERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEE 408
+++ R +E+ + + + E++ +E E E E+ E ++ A +
Sbjct: 1219 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1278
Query: 409 -EDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPAD 467
+D E ++Q E K+ + + G E E +D +T S EL+T
Sbjct: 1279 IKDYELQLVTYKAQLEPVASPAKKPK-VQSGSESVIQEYVDLRTHYS--ELTTL----TS 1331
Query: 468 DVVSIIEEVEEKRKRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVL 527
+ I E + + ++ + R A + A A A+ + E
Sbjct: 1332 QYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1391
Query: 528 PPWDREEDEVYPPGPYHPFPNYIRPRTLQPPSALRRRHYHHALPPSRHYPGREAQARRAQ 587
R ++EV +R + ++R L R E QA+ Q
Sbjct: 1392 ELQQRMQEEV------------VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1439
Query: 588 EEAEAEERRLQEQEEL 603
EA AE RL+ +EE+
Sbjct: 1440 AEA-AERSRLRIEEEI 1454
Score = 33.9 bits (76), Expect = 0.45
Identities = 36/118 (30%), Positives = 54/118 (45%), Gaps = 23/118 (19%)
Query: 294 ERLLQQGLAQVEAGRRQAEATRQAAAQE-ERLADLASDLLLQYLLQGGARQRGLGGRGLQ 352
E+L Q +A+ + R + + +Q QE +RL + AR+R Q
Sbjct: 2517 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE----------ARRR-------Q 2559
Query: 353 EAAEERESAREEE--EAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEE 408
AEE ++EE + EQ+RR EE + EE++ E EE RA AL +EE
Sbjct: 2560 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEE 2614
Score = 30.4 bits (67), Expect = 5.0
Identities = 79/386 (20%), Positives = 134/386 (34%), Gaps = 47/386 (12%)
Query: 120 RSQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQE 179
R++ S + + AA R Q E + +E E +L QE + +
Sbjct: 2027 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2086
Query: 180 TAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSG 239
AAE RV E + + +V E L A Q QAR
Sbjct: 2087 RRAAEEAEEA----RVQAEREAAQS---------RRQVEEAERLKQSAEEQAQARAQAQA 2133
Query: 240 PLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARR-PESALLGGSEAGERLL- 297
+ K E ++ + +A + Q A K ++ E L ++ + L
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAAL---RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2190
Query: 298 ----------QQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLG 347
Q+ L E R +AEAT +AA Q ++ + + +Q + R
Sbjct: 2191 LRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR--- 2246
Query: 348 GRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNAL--LF 405
EA R+++ ++ + E++ + EEAA A+EA R RQ A L
Sbjct: 2247 ----IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2302
Query: 406 AEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGE---------EEDDEEMDPQTIDSLI 456
+ E ++K + + EAE ++ E +ED E+M Q +
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2362
Query: 457 ELSTKLHLPADDVVSIIEEVEEKRKR 482
L + + E E + R
Sbjct: 2363 GFQRTLEAERQRQLEMSAEAERLKLR 2388
Score = 29.6 bits (65), Expect = 8.5
Identities = 15/35 (42%), Positives = 22/35 (62%)
Query: 580 EAQARRAQEEAEAEERRLQEQEELENYIEHVLLRR 614
EAQ R+AQEEAE R++Q++ + + E L R
Sbjct: 1486 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1520
>gi|41322914 plectin 1 isoform 10 [Homo sapiens]
Length = 4551
Score = 56.6 bits (135), Expect = 7e-08
Identities = 98/371 (26%), Positives = 152/371 (40%), Gaps = 43/371 (11%)
Query: 149 ASDPSEELEALASLLQELRDFSPSS--AKRQQETAAAETETRTHTLTRV-NLESPGPERV 205
A D ++ ++ LQ+LR S + AK +Q AA + R RV L+ ER
Sbjct: 1412 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1471
Query: 206 WRASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPL 265
+ GE QA RA + QA+ E + V +A L
Sbjct: 1472 RGGAEGELQAL---RARAEEAEAQKRQAQ-------EEAERLRRQVQDESQRKRQAEVEL 1521
Query: 266 SKAYQGVAAPFPKARRPESAL----LGGSEAGERLLQQGLAQVEAGRRQAEA--TRQAAA 319
+ + A + +R AL L EA RL Q A+VE R+ A T Q +A
Sbjct: 1522 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ---AEVERARQVQVALETAQRSA 1578
Query: 320 QEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEER-----ESAREEEEAEQERRGG 374
+ E + AS L+ ++ + L+E AE R E+ R EEAE+E
Sbjct: 1579 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL--- 1635
Query: 375 EERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEG 434
ER + EA +AEE A+Q +L AE AE ++ + E RR +AE
Sbjct: 1636 -ERWQLKANEALRLRLQAEEV--AQQKSLAQAE-------AEKQKEEAEREARRRGKAEE 1685
Query: 435 TEEGGEEEDDEEMDPQTIDSLIELSTKLHLPAD-DVVSIIEEVEEKRKRKKNAPPEPVPP 493
E ++E++ Q L E + + L A+ +++ + E E+ ++++ E
Sbjct: 1686 QAVRQRELAEQELEKQR--QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1743
Query: 494 PRAAPAPTHVR 504
R A A T R
Sbjct: 1744 QREAAAATQKR 1754
Score = 50.1 bits (118), Expect = 6e-06
Identities = 105/397 (26%), Positives = 149/397 (37%), Gaps = 67/397 (16%)
Query: 87 LQALDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPP-----RPQ 141
LQ L + + + ++Q E + + E +R L A E A R +
Sbjct: 1426 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1485
Query: 142 TPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQET-----------AAAETETRTH 190
E + EE E L +Q+ S KRQ E AA E +
Sbjct: 1486 AEEAEAQKRQAQEEAERLRRQVQD-----ESQRKRQAEVELASRVKAEAEAAREKQRALQ 1540
Query: 191 TLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEG 250
L + L++ ER R QA V ERA A Q R ++ + F E
Sbjct: 1541 ALEELRLQAEEAERRLR------QAEV-ERARQVQVALETAQ-RSAEAELQSKRASFAEK 1592
Query: 251 VSSPKTHLGE---ALAPLSKAYQGVAAPFPKARRPES---------------ALLGGSEA 292
+ + L E A+A L + + A +A R AL +A
Sbjct: 1593 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1652
Query: 293 GERLLQQGLAQVEAGRRQAEATRQAA--AQEERLADLASDLLLQYLLQGGARQRGLG-GR 349
E Q+ LAQ EA +++ EA R+A + E A +L Q L +QR L G
Sbjct: 1653 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL----EKQRQLAEGT 1708
Query: 350 GLQEAAEERESAR---EEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAE------RARQ 400
Q A E+E R E E+ EQ+R+ EE + EAA A + +E E RA
Sbjct: 1709 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1768
Query: 401 NALLF----AEEEDGEAGAEDKRSQEETPGHRRKEAE 433
LL AEEE + K+ E G R+ AE
Sbjct: 1769 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1805
Score = 49.3 bits (116), Expect = 1e-05
Identities = 56/198 (28%), Positives = 88/198 (44%), Gaps = 34/198 (17%)
Query: 267 KAYQGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLAD 326
+ + +AA AR+ ++AL E ERL A+VE RR E Q +A++ +LA
Sbjct: 1993 RVQKSLAAEEEAARQRKAAL----EEVERLK----AKVEEARRLRERAEQESARQLQLAQ 2044
Query: 327 LASDLLLQY---------------LLQGGARQRGLGGRGLQEAAEERESAREEEEAEQER 371
A+ LQ L Q +++ + + EA R +A E EEA
Sbjct: 2045 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-- 2102
Query: 372 RGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAE-EEDGEAGAEDKRSQEETPGHRRK 430
+ + EAA++ + EEAER +Q+A A+ +A AE R + E RR
Sbjct: 2103 --------QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2154
Query: 431 EAEGTEEGGEEEDDEEMD 448
+AE ++ D EM+
Sbjct: 2155 QAEQAALRQKQAADAEME 2172
Score = 48.9 bits (115), Expect = 1e-05
Identities = 81/345 (23%), Positives = 139/345 (40%), Gaps = 78/345 (22%)
Query: 295 RLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQ-YLLQGGARQRGLGGRGLQE 353
+ + + L ++E R AE +Q A + ERLA++ + L Q L + A+ + R +E
Sbjct: 1339 KFISETLRRMEEEERLAE--QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE 1396
Query: 354 AAE--ERESAREEE---EAEQERRGGEERVGE-EDEEAAEAEAEAEEAERARQNALLFAE 407
+ + E R EE +A+Q++R +E + + AE +A+A +AE A ++ L E
Sbjct: 1397 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1456
Query: 408 E-----------EDGEAGAED-----KRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQT 451
E E GAE + EE +R+ E E + DE +
Sbjct: 1457 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1516
Query: 452 IDSLIELSTKLHLPADDV------VSIIEEV----EEKRKRKKNAPPEPVPPPRAAPAPT 501
+ +EL++++ A+ + +EE+ EE +R + A E RA
Sbjct: 1517 AE--VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE-----RARQVQV 1569
Query: 502 HVRSPQPPPPAPAPARDELPDWNEVLPPWDREEDEVYPPGPYHPFPNYIRPRTLQPPSAL 561
+ + Q A A + + + E +T Q +L
Sbjct: 1570 ALETAQRS--AEAELQSKRASFAE---------------------------KTAQLERSL 1600
Query: 562 RRRHYHHALPPSRHYPGREAQARRAQEEAEAEERRLQEQEELENY 606
+ H A RE RRAQ++AEAE R + + ELE +
Sbjct: 1601 QEEHVAVAQL-------REEAERRAQQQAEAERAREEAERELERW 1638
Score = 47.8 bits (112), Expect = 3e-05
Identities = 86/398 (21%), Positives = 145/398 (36%), Gaps = 26/398 (6%)
Query: 90 LDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEA 149
L+ ASP Q G E E + T S+ +L + + R E
Sbjct: 1297 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1356
Query: 150 SDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWRAS 209
+EE E LA + L + Q A AE E + L+ E V R
Sbjct: 1357 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK-------ELQQRMQEEVVRRE 1409
Query: 210 WGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAY 269
A+ +R+ Q R + + E + + E + +
Sbjct: 1410 EAAVDAQQQKRSI----QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1465
Query: 270 QGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLAS 329
+ A AL +E E +Q + E RRQ + Q Q E +LAS
Sbjct: 1466 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE--VELAS 1523
Query: 330 DLLLQYLLQGGARQRGLGGRGLQEAAEERESA-REEEEAEQERRGGEERVGEEDEEAAEA 388
+ + AR++ + L+E + E A R +AE ER + E + +AEA
Sbjct: 1524 RVKAE---AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1580
Query: 389 EAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMD 448
E +++ A A + A L ++ R + E RR + + E EE + E++
Sbjct: 1581 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE----RRAQQQAEAERAREEAERELE 1636
Query: 449 PQTIDSLIELSTKLHLPADDVV---SIIEEVEEKRKRK 483
+ + + +L L A++V S+ + EK+K +
Sbjct: 1637 RWQLKA--NEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1672
Score = 47.8 bits (112), Expect = 3e-05
Identities = 100/423 (23%), Positives = 158/423 (37%), Gaps = 48/423 (11%)
Query: 53 DGSAPEVRGARNSEPQDEGELFQGVDPRALAAVLLQALDRPASPPAPSGSQQGPEEEAA- 111
+G+A + A + E QG R L L L R A+ A + +Q E E A
Sbjct: 1706 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA--AATQKRQELEAELAK 1763
Query: 112 -----EALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQEL 166
E LL R++ S E + E ++ + L ALA +
Sbjct: 1764 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQ 1820
Query: 167 RDFSPSSAKRQ---------QETAAAETETRTHTLTRVNLESPGPE--RVWRASWGE-FQ 214
R + A RQ ++ AA TR T + L+ E R+ R + E FQ
Sbjct: 1821 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1880
Query: 215 ARVPERAPLPPPAPSQ---FQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQG 271
R E A + Q R L E + + E + L +++
Sbjct: 1881 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1940
Query: 272 VAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDL 331
AA + + +E R +Q A++EA R+ RQ AA+EER A +
Sbjct: 1941 AAAGKAELELELGRIRSNAEDTLRSKEQ--AELEAARQ-----RQLAAEEERRRREAEER 1993
Query: 332 LLQYLL--QGGARQRGLGGRGLQEAAEERESAREEEEAEQERRGGEE--RVGEEDEEAAE 387
+ + L + ARQR L+E ER A+ EE R +E R + +EAA+
Sbjct: 1994 VQKSLAAEEEAARQRKAA---LEEV--ERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2048
Query: 388 AEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEM 447
+AEE A FA ++ + + + ++ R EAE EE ++ +
Sbjct: 2049 KRLQAEEKAHA------FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2102
Query: 448 DPQ 450
+
Sbjct: 2103 QAE 2105
Score = 46.6 bits (109), Expect = 7e-05
Identities = 63/249 (25%), Positives = 103/249 (41%), Gaps = 36/249 (14%)
Query: 174 AKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQA 233
A RQ++ AA E R ERV ++ E +A +A L + +A
Sbjct: 1973 AARQRQLAAEEERRRREA----------EERVQKSLAAEEEAARQRKAALEEV--ERLKA 2020
Query: 234 RMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAG 293
++ ++ L E E S+ + L + A + A F ++ E L +
Sbjct: 2021 KVEEARRLRER---AEQESARQLQLAQEAAQKRLQAEEKAHAFA-VQQKEQELQQTLQQE 2076
Query: 294 ERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQE 353
+ +L Q + EA RR AE +A Q ER A A+ R R ++E
Sbjct: 2077 QSVLDQLRGEAEAARRAAEEAEEARVQAEREA---------------AQSR----RQVEE 2117
Query: 354 AAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEA 413
A ++SA E+ +A + + E++ +E E+ A A+AE+A RQ AE E +
Sbjct: 2118 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA-ALRQKQAADAEMEKHKK 2176
Query: 414 GAEDKRSQE 422
AE Q+
Sbjct: 2177 FAEQTLRQK 2185
Score = 41.6 bits (96), Expect = 0.002
Identities = 54/168 (32%), Positives = 75/168 (44%), Gaps = 15/168 (8%)
Query: 278 KARRPESALLGGSEAGERLLQQGLAQVEAGRR-QAEATRQAAAQEERLADLASDLLLQYL 336
KA+ E+ L E Q LAQ A +R QAE A A +++ +L L +
Sbjct: 2019 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2078
Query: 337 LQGGARQRGLGGRGLQEAAEERESAR--EEEEAEQERRGGEE-----RVGEEDEEA-AEA 388
+ R R AAEE E AR E EA Q RR EE + EE +A A+A
Sbjct: 2079 VLDQLRGEAEAAR---RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2135
Query: 389 EAEAEEAER-ARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGT 435
+A AE+ + A Q A A+ E +A K++ + +K AE T
Sbjct: 2136 QAAAEKLRKEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQT 2181
Score = 38.5 bits (88), Expect = 0.018
Identities = 84/370 (22%), Positives = 140/370 (37%), Gaps = 56/370 (15%)
Query: 149 ASDPSEELEA-LASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWR 207
A+ +ELEA LA + E+ S A+ ++E+ + +++
Sbjct: 1750 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL---------------E 1794
Query: 208 ASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPK-THLGEALAPLS 266
A G F+ E A L A + R E V + K +GEA +
Sbjct: 1795 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1854
Query: 267 KAYQGVAAPFPKARRPESALLGGSEAGERL-LQQGLAQVEAG--RRQAEATRQAAAQEER 323
+A +A +A L EA +R L++ AQ +A R A+ + + ++ ER
Sbjct: 1855 EAE--IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1912
Query: 324 LADLASDLLLQ-------YLLQGGARQRGLGGRG--------LQEAAEERESAREEEEAE 368
L D L Q L + ++ G+ ++ AE+ ++E+ E E
Sbjct: 1913 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 1972
Query: 369 QERR----GGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAED-----KR 419
R+ EER E EE + AEE E ARQ E E +A E+ +R
Sbjct: 1973 AARQRQLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKVEEARRLRER 2031
Query: 420 SQEET---------PGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVV 470
+++E+ +R +AE + E+ QT+ + +L A+
Sbjct: 2032 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2091
Query: 471 SIIEEVEEKR 480
EE EE R
Sbjct: 2092 RAAEEAEEAR 2101
Score = 38.1 bits (87), Expect = 0.024
Identities = 71/289 (24%), Positives = 115/289 (39%), Gaps = 33/289 (11%)
Query: 148 EASDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWR 207
+A + L+A A LLQ+ ++ + A+R QE + E L E+ G +R
Sbjct: 2321 QAVQEATRLKAEAELLQQQKELAQEQARRLQE----DKEQMAQQLAE---ETQGFQRTLE 2373
Query: 208 ASWG---EFQARVPERAPLPPPAPSQFQARMPDSGPL--PETHKFGEGVSSPKTHLGEAL 262
A E A ER L S+ QAR + + + GE + + E +
Sbjct: 2374 AERQRQLEMSAEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2432
Query: 263 APLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQG-LAQVEAGRRQAEATRQAAAQE 321
+ A R A+ E+L Q+ L Q+++ Q Q +
Sbjct: 2433 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2492
Query: 322 ERLADL---ASDLLLQ---YLLQGGARQRGLGGRGLQEAAEERESA-REEEEAEQERRGG 374
+ L D LLQ ++ Q A+ L + +A + RE R++++ EQER
Sbjct: 2493 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER--- 2549
Query: 375 EERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEE 423
+R+ EEA + EAEE R +Q L E++ +R QEE
Sbjct: 2550 -QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ--------RRQQEE 2589
Score = 35.4 bits (80), Expect = 0.16
Identities = 85/376 (22%), Positives = 135/376 (35%), Gaps = 46/376 (12%)
Query: 243 ETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQGLA 302
E K + V + L A L K A P L G E GERL Q+
Sbjct: 1114 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR--- 1170
Query: 303 QVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQ-----EAAEE 357
G R E R ER+A L + L Q RQR L G Q E+A+
Sbjct: 1171 ---HGERDVEVER----WRERVAQLL-ERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1222
Query: 358 -----RESAREEEEAE----QERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEE 408
+++ R +E+ + + + E++ +E E E E+ E ++ A +
Sbjct: 1223 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1282
Query: 409 -EDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPAD 467
+D E ++Q E K+ + + G E E +D +T S EL+T
Sbjct: 1283 IKDYELQLVTYKAQLEPVASPAKKPK-VQSGSESVIQEYVDLRTHYS--ELTTL----TS 1335
Query: 468 DVVSIIEEVEEKRKRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVL 527
+ I E + + ++ + R A + A A A+ + E
Sbjct: 1336 QYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1395
Query: 528 PPWDREEDEVYPPGPYHPFPNYIRPRTLQPPSALRRRHYHHALPPSRHYPGREAQARRAQ 587
R ++EV +R + ++R L R E QA+ Q
Sbjct: 1396 ELQQRMQEEV------------VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1443
Query: 588 EEAEAEERRLQEQEEL 603
EA AE RL+ +EE+
Sbjct: 1444 AEA-AERSRLRIEEEI 1458
Score = 33.9 bits (76), Expect = 0.45
Identities = 36/118 (30%), Positives = 54/118 (45%), Gaps = 23/118 (19%)
Query: 294 ERLLQQGLAQVEAGRRQAEATRQAAAQE-ERLADLASDLLLQYLLQGGARQRGLGGRGLQ 352
E+L Q +A+ + R + + +Q QE +RL + AR+R Q
Sbjct: 2521 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE----------ARRR-------Q 2563
Query: 353 EAAEERESAREEE--EAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEE 408
AEE ++EE + EQ+RR EE + EE++ E EE RA AL +EE
Sbjct: 2564 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEE 2618
Score = 30.4 bits (67), Expect = 5.0
Identities = 79/386 (20%), Positives = 134/386 (34%), Gaps = 47/386 (12%)
Query: 120 RSQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQE 179
R++ S + + AA R Q E + +E E +L QE + +
Sbjct: 2031 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2090
Query: 180 TAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSG 239
AAE RV E + + +V E L A Q QAR
Sbjct: 2091 RRAAEEAEEA----RVQAEREAAQS---------RRQVEEAERLKQSAEEQAQARAQAQA 2137
Query: 240 PLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARR-PESALLGGSEAGERLL- 297
+ K E ++ + +A + Q A K ++ E L ++ + L
Sbjct: 2138 AAEKLRKEAEQEAARRAQAEQAAL---RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2194
Query: 298 ----------QQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLG 347
Q+ L E R +AEAT +AA Q ++ + + +Q + R
Sbjct: 2195 LRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR--- 2250
Query: 348 GRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNAL--LF 405
EA R+++ ++ + E++ + EEAA A+EA R RQ A L
Sbjct: 2251 ----IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2306
Query: 406 AEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGE---------EEDDEEMDPQTIDSLI 456
+ E ++K + + EAE ++ E +ED E+M Q +
Sbjct: 2307 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2366
Query: 457 ELSTKLHLPADDVVSIIEEVEEKRKR 482
L + + E E + R
Sbjct: 2367 GFQRTLEAERQRQLEMSAEAERLKLR 2392
Score = 29.6 bits (65), Expect = 8.5
Identities = 15/35 (42%), Positives = 22/35 (62%)
Query: 580 EAQARRAQEEAEAEERRLQEQEELENYIEHVLLRR 614
EAQ R+AQEEAE R++Q++ + + E L R
Sbjct: 1490 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1524
>gi|41322919 plectin 1 isoform 8 [Homo sapiens]
Length = 4547
Score = 56.6 bits (135), Expect = 7e-08
Identities = 98/371 (26%), Positives = 152/371 (40%), Gaps = 43/371 (11%)
Query: 149 ASDPSEELEALASLLQELRDFSPSS--AKRQQETAAAETETRTHTLTRV-NLESPGPERV 205
A D ++ ++ LQ+LR S + AK +Q AA + R RV L+ ER
Sbjct: 1408 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1467
Query: 206 WRASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPL 265
+ GE QA RA + QA+ E + V +A L
Sbjct: 1468 RGGAEGELQAL---RARAEEAEAQKRQAQ-------EEAERLRRQVQDESQRKRQAEVEL 1517
Query: 266 SKAYQGVAAPFPKARRPESAL----LGGSEAGERLLQQGLAQVEAGRRQAEA--TRQAAA 319
+ + A + +R AL L EA RL Q A+VE R+ A T Q +A
Sbjct: 1518 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ---AEVERARQVQVALETAQRSA 1574
Query: 320 QEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEER-----ESAREEEEAEQERRGG 374
+ E + AS L+ ++ + L+E AE R E+ R EEAE+E
Sbjct: 1575 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL--- 1631
Query: 375 EERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEG 434
ER + EA +AEE A+Q +L AE AE ++ + E RR +AE
Sbjct: 1632 -ERWQLKANEALRLRLQAEEV--AQQKSLAQAE-------AEKQKEEAEREARRRGKAEE 1681
Query: 435 TEEGGEEEDDEEMDPQTIDSLIELSTKLHLPAD-DVVSIIEEVEEKRKRKKNAPPEPVPP 493
E ++E++ Q L E + + L A+ +++ + E E+ ++++ E
Sbjct: 1682 QAVRQRELAEQELEKQR--QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1739
Query: 494 PRAAPAPTHVR 504
R A A T R
Sbjct: 1740 QREAAAATQKR 1750
Score = 50.1 bits (118), Expect = 6e-06
Identities = 105/397 (26%), Positives = 149/397 (37%), Gaps = 67/397 (16%)
Query: 87 LQALDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPP-----RPQ 141
LQ L + + + ++Q E + + E +R L A E A R +
Sbjct: 1422 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1481
Query: 142 TPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQET-----------AAAETETRTH 190
E + EE E L +Q+ S KRQ E AA E +
Sbjct: 1482 AEEAEAQKRQAQEEAERLRRQVQD-----ESQRKRQAEVELASRVKAEAEAAREKQRALQ 1536
Query: 191 TLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEG 250
L + L++ ER R QA V ERA A Q R ++ + F E
Sbjct: 1537 ALEELRLQAEEAERRLR------QAEV-ERARQVQVALETAQ-RSAEAELQSKRASFAEK 1588
Query: 251 VSSPKTHLGE---ALAPLSKAYQGVAAPFPKARRPES---------------ALLGGSEA 292
+ + L E A+A L + + A +A R AL +A
Sbjct: 1589 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1648
Query: 293 GERLLQQGLAQVEAGRRQAEATRQAA--AQEERLADLASDLLLQYLLQGGARQRGLG-GR 349
E Q+ LAQ EA +++ EA R+A + E A +L Q L +QR L G
Sbjct: 1649 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL----EKQRQLAEGT 1704
Query: 350 GLQEAAEERESAR---EEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAE------RARQ 400
Q A E+E R E E+ EQ+R+ EE + EAA A + +E E RA
Sbjct: 1705 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1764
Query: 401 NALLF----AEEEDGEAGAEDKRSQEETPGHRRKEAE 433
LL AEEE + K+ E G R+ AE
Sbjct: 1765 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1801
Score = 49.3 bits (116), Expect = 1e-05
Identities = 56/198 (28%), Positives = 88/198 (44%), Gaps = 34/198 (17%)
Query: 267 KAYQGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLAD 326
+ + +AA AR+ ++AL E ERL A+VE RR E Q +A++ +LA
Sbjct: 1989 RVQKSLAAEEEAARQRKAAL----EEVERLK----AKVEEARRLRERAEQESARQLQLAQ 2040
Query: 327 LASDLLLQY---------------LLQGGARQRGLGGRGLQEAAEERESAREEEEAEQER 371
A+ LQ L Q +++ + + EA R +A E EEA
Sbjct: 2041 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-- 2098
Query: 372 RGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAE-EEDGEAGAEDKRSQEETPGHRRK 430
+ + EAA++ + EEAER +Q+A A+ +A AE R + E RR
Sbjct: 2099 --------QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2150
Query: 431 EAEGTEEGGEEEDDEEMD 448
+AE ++ D EM+
Sbjct: 2151 QAEQAALRQKQAADAEME 2168
Score = 48.9 bits (115), Expect = 1e-05
Identities = 81/345 (23%), Positives = 139/345 (40%), Gaps = 78/345 (22%)
Query: 295 RLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQ-YLLQGGARQRGLGGRGLQE 353
+ + + L ++E R AE +Q A + ERLA++ + L Q L + A+ + R +E
Sbjct: 1335 KFISETLRRMEEEERLAE--QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE 1392
Query: 354 AAE--ERESAREEE---EAEQERRGGEERVGE-EDEEAAEAEAEAEEAERARQNALLFAE 407
+ + E R EE +A+Q++R +E + + AE +A+A +AE A ++ L E
Sbjct: 1393 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1452
Query: 408 E-----------EDGEAGAED-----KRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQT 451
E E GAE + EE +R+ E E + DE +
Sbjct: 1453 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1512
Query: 452 IDSLIELSTKLHLPADDV------VSIIEEV----EEKRKRKKNAPPEPVPPPRAAPAPT 501
+ +EL++++ A+ + +EE+ EE +R + A E RA
Sbjct: 1513 AE--VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE-----RARQVQV 1565
Query: 502 HVRSPQPPPPAPAPARDELPDWNEVLPPWDREEDEVYPPGPYHPFPNYIRPRTLQPPSAL 561
+ + Q A A + + + E +T Q +L
Sbjct: 1566 ALETAQRS--AEAELQSKRASFAE---------------------------KTAQLERSL 1596
Query: 562 RRRHYHHALPPSRHYPGREAQARRAQEEAEAEERRLQEQEELENY 606
+ H A RE RRAQ++AEAE R + + ELE +
Sbjct: 1597 QEEHVAVAQL-------REEAERRAQQQAEAERAREEAERELERW 1634
Score = 47.8 bits (112), Expect = 3e-05
Identities = 86/398 (21%), Positives = 145/398 (36%), Gaps = 26/398 (6%)
Query: 90 LDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEA 149
L+ ASP Q G E E + T S+ +L + + R E
Sbjct: 1293 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1352
Query: 150 SDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWRAS 209
+EE E LA + L + Q A AE E + L+ E V R
Sbjct: 1353 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK-------ELQQRMQEEVVRRE 1405
Query: 210 WGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAY 269
A+ +R+ Q R + + E + + E + +
Sbjct: 1406 EAAVDAQQQKRSI----QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1461
Query: 270 QGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLAS 329
+ A AL +E E +Q + E RRQ + Q Q E +LAS
Sbjct: 1462 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE--VELAS 1519
Query: 330 DLLLQYLLQGGARQRGLGGRGLQEAAEERESA-REEEEAEQERRGGEERVGEEDEEAAEA 388
+ + AR++ + L+E + E A R +AE ER + E + +AEA
Sbjct: 1520 RVKAE---AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1576
Query: 389 EAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMD 448
E +++ A A + A L ++ R + E RR + + E EE + E++
Sbjct: 1577 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE----RRAQQQAEAERAREEAERELE 1632
Query: 449 PQTIDSLIELSTKLHLPADDVV---SIIEEVEEKRKRK 483
+ + + +L L A++V S+ + EK+K +
Sbjct: 1633 RWQLKA--NEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1668
Score = 47.8 bits (112), Expect = 3e-05
Identities = 100/423 (23%), Positives = 158/423 (37%), Gaps = 48/423 (11%)
Query: 53 DGSAPEVRGARNSEPQDEGELFQGVDPRALAAVLLQALDRPASPPAPSGSQQGPEEEAA- 111
+G+A + A + E QG R L L L R A+ A + +Q E E A
Sbjct: 1702 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA--AATQKRQELEAELAK 1759
Query: 112 -----EALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQEL 166
E LL R++ S E + E ++ + L ALA +
Sbjct: 1760 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQ 1816
Query: 167 RDFSPSSAKRQ---------QETAAAETETRTHTLTRVNLESPGPE--RVWRASWGE-FQ 214
R + A RQ ++ AA TR T + L+ E R+ R + E FQ
Sbjct: 1817 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1876
Query: 215 ARVPERAPLPPPAPSQ---FQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQG 271
R E A + Q R L E + + E + L +++
Sbjct: 1877 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1936
Query: 272 VAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDL 331
AA + + +E R +Q A++EA R+ RQ AA+EER A +
Sbjct: 1937 AAAGKAELELELGRIRSNAEDTLRSKEQ--AELEAARQ-----RQLAAEEERRRREAEER 1989
Query: 332 LLQYLL--QGGARQRGLGGRGLQEAAEERESAREEEEAEQERRGGEE--RVGEEDEEAAE 387
+ + L + ARQR L+E ER A+ EE R +E R + +EAA+
Sbjct: 1990 VQKSLAAEEEAARQRKAA---LEEV--ERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2044
Query: 388 AEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEM 447
+AEE A FA ++ + + + ++ R EAE EE ++ +
Sbjct: 2045 KRLQAEEKAHA------FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2098
Query: 448 DPQ 450
+
Sbjct: 2099 QAE 2101
Score = 46.6 bits (109), Expect = 7e-05
Identities = 63/249 (25%), Positives = 103/249 (41%), Gaps = 36/249 (14%)
Query: 174 AKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQA 233
A RQ++ AA E R ERV ++ E +A +A L + +A
Sbjct: 1969 AARQRQLAAEEERRRREA----------EERVQKSLAAEEEAARQRKAALEEV--ERLKA 2016
Query: 234 RMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAG 293
++ ++ L E E S+ + L + A + A F ++ E L +
Sbjct: 2017 KVEEARRLRER---AEQESARQLQLAQEAAQKRLQAEEKAHAFA-VQQKEQELQQTLQQE 2072
Query: 294 ERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQE 353
+ +L Q + EA RR AE +A Q ER A A+ R R ++E
Sbjct: 2073 QSVLDQLRGEAEAARRAAEEAEEARVQAEREA---------------AQSR----RQVEE 2113
Query: 354 AAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEA 413
A ++SA E+ +A + + E++ +E E+ A A+AE+A RQ AE E +
Sbjct: 2114 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA-ALRQKQAADAEMEKHKK 2172
Query: 414 GAEDKRSQE 422
AE Q+
Sbjct: 2173 FAEQTLRQK 2181
Score = 41.6 bits (96), Expect = 0.002
Identities = 54/168 (32%), Positives = 75/168 (44%), Gaps = 15/168 (8%)
Query: 278 KARRPESALLGGSEAGERLLQQGLAQVEAGRR-QAEATRQAAAQEERLADLASDLLLQYL 336
KA+ E+ L E Q LAQ A +R QAE A A +++ +L L +
Sbjct: 2015 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2074
Query: 337 LQGGARQRGLGGRGLQEAAEERESAR--EEEEAEQERRGGEE-----RVGEEDEEA-AEA 388
+ R R AAEE E AR E EA Q RR EE + EE +A A+A
Sbjct: 2075 VLDQLRGEAEAAR---RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2131
Query: 389 EAEAEEAER-ARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGT 435
+A AE+ + A Q A A+ E +A K++ + +K AE T
Sbjct: 2132 QAAAEKLRKEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQT 2177
Score = 38.5 bits (88), Expect = 0.018
Identities = 84/370 (22%), Positives = 140/370 (37%), Gaps = 56/370 (15%)
Query: 149 ASDPSEELEA-LASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWR 207
A+ +ELEA LA + E+ S A+ ++E+ + +++
Sbjct: 1746 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL---------------E 1790
Query: 208 ASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPK-THLGEALAPLS 266
A G F+ E A L A + R E V + K +GEA +
Sbjct: 1791 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1850
Query: 267 KAYQGVAAPFPKARRPESALLGGSEAGERL-LQQGLAQVEAG--RRQAEATRQAAAQEER 323
+A +A +A L EA +R L++ AQ +A R A+ + + ++ ER
Sbjct: 1851 EAE--IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1908
Query: 324 LADLASDLLLQ-------YLLQGGARQRGLGGRG--------LQEAAEERESAREEEEAE 368
L D L Q L + ++ G+ ++ AE+ ++E+ E E
Sbjct: 1909 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 1968
Query: 369 QERR----GGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAED-----KR 419
R+ EER E EE + AEE E ARQ E E +A E+ +R
Sbjct: 1969 AARQRQLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKVEEARRLRER 2027
Query: 420 SQEET---------PGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVV 470
+++E+ +R +AE + E+ QT+ + +L A+
Sbjct: 2028 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2087
Query: 471 SIIEEVEEKR 480
EE EE R
Sbjct: 2088 RAAEEAEEAR 2097
Score = 38.1 bits (87), Expect = 0.024
Identities = 71/289 (24%), Positives = 115/289 (39%), Gaps = 33/289 (11%)
Query: 148 EASDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWR 207
+A + L+A A LLQ+ ++ + A+R QE + E L E+ G +R
Sbjct: 2317 QAVQEATRLKAEAELLQQQKELAQEQARRLQE----DKEQMAQQLAE---ETQGFQRTLE 2369
Query: 208 ASWG---EFQARVPERAPLPPPAPSQFQARMPDSGPL--PETHKFGEGVSSPKTHLGEAL 262
A E A ER L S+ QAR + + + GE + + E +
Sbjct: 2370 AERQRQLEMSAEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2428
Query: 263 APLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQG-LAQVEAGRRQAEATRQAAAQE 321
+ A R A+ E+L Q+ L Q+++ Q Q +
Sbjct: 2429 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2488
Query: 322 ERLADL---ASDLLLQ---YLLQGGARQRGLGGRGLQEAAEERESA-REEEEAEQERRGG 374
+ L D LLQ ++ Q A+ L + +A + RE R++++ EQER
Sbjct: 2489 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER--- 2545
Query: 375 EERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEE 423
+R+ EEA + EAEE R +Q L E++ +R QEE
Sbjct: 2546 -QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ--------RRQQEE 2585
Score = 35.4 bits (80), Expect = 0.16
Identities = 85/376 (22%), Positives = 135/376 (35%), Gaps = 46/376 (12%)
Query: 243 ETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQGLA 302
E K + V + L A L K A P L G E GERL Q+
Sbjct: 1110 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR--- 1166
Query: 303 QVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQ-----EAAEE 357
G R E R ER+A L + L Q RQR L G Q E+A+
Sbjct: 1167 ---HGERDVEVER----WRERVAQLL-ERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1218
Query: 358 -----RESAREEEEAE----QERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEE 408
+++ R +E+ + + + E++ +E E E E+ E ++ A +
Sbjct: 1219 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1278
Query: 409 -EDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPAD 467
+D E ++Q E K+ + + G E E +D +T S EL+T
Sbjct: 1279 IKDYELQLVTYKAQLEPVASPAKKPK-VQSGSESVIQEYVDLRTHYS--ELTTL----TS 1331
Query: 468 DVVSIIEEVEEKRKRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVL 527
+ I E + + ++ + R A + A A A+ + E
Sbjct: 1332 QYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1391
Query: 528 PPWDREEDEVYPPGPYHPFPNYIRPRTLQPPSALRRRHYHHALPPSRHYPGREAQARRAQ 587
R ++EV +R + ++R L R E QA+ Q
Sbjct: 1392 ELQQRMQEEV------------VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1439
Query: 588 EEAEAEERRLQEQEEL 603
EA AE RL+ +EE+
Sbjct: 1440 AEA-AERSRLRIEEEI 1454
Score = 33.9 bits (76), Expect = 0.45
Identities = 36/118 (30%), Positives = 54/118 (45%), Gaps = 23/118 (19%)
Query: 294 ERLLQQGLAQVEAGRRQAEATRQAAAQE-ERLADLASDLLLQYLLQGGARQRGLGGRGLQ 352
E+L Q +A+ + R + + +Q QE +RL + AR+R Q
Sbjct: 2517 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE----------ARRR-------Q 2559
Query: 353 EAAEERESAREEE--EAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEE 408
AEE ++EE + EQ+RR EE + EE++ E EE RA AL +EE
Sbjct: 2560 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEE 2614
Score = 30.4 bits (67), Expect = 5.0
Identities = 79/386 (20%), Positives = 134/386 (34%), Gaps = 47/386 (12%)
Query: 120 RSQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQE 179
R++ S + + AA R Q E + +E E +L QE + +
Sbjct: 2027 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2086
Query: 180 TAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSG 239
AAE RV E + + +V E L A Q QAR
Sbjct: 2087 RRAAEEAEEA----RVQAEREAAQS---------RRQVEEAERLKQSAEEQAQARAQAQA 2133
Query: 240 PLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARR-PESALLGGSEAGERLL- 297
+ K E ++ + +A + Q A K ++ E L ++ + L
Sbjct: 2134 AAEKLRKEAEQEAARRAQAEQAAL---RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2190
Query: 298 ----------QQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLG 347
Q+ L E R +AEAT +AA Q ++ + + +Q + R
Sbjct: 2191 LRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR--- 2246
Query: 348 GRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNAL--LF 405
EA R+++ ++ + E++ + EEAA A+EA R RQ A L
Sbjct: 2247 ----IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2302
Query: 406 AEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGE---------EEDDEEMDPQTIDSLI 456
+ E ++K + + EAE ++ E +ED E+M Q +
Sbjct: 2303 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2362
Query: 457 ELSTKLHLPADDVVSIIEEVEEKRKR 482
L + + E E + R
Sbjct: 2363 GFQRTLEAERQRQLEMSAEAERLKLR 2388
Score = 29.6 bits (65), Expect = 8.5
Identities = 15/35 (42%), Positives = 22/35 (62%)
Query: 580 EAQARRAQEEAEAEERRLQEQEELENYIEHVLLRR 614
EAQ R+AQEEAE R++Q++ + + E L R
Sbjct: 1486 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1520
>gi|41322910 plectin 1 isoform 7 [Homo sapiens]
Length = 4515
Score = 56.6 bits (135), Expect = 7e-08
Identities = 98/371 (26%), Positives = 152/371 (40%), Gaps = 43/371 (11%)
Query: 149 ASDPSEELEALASLLQELRDFSPSS--AKRQQETAAAETETRTHTLTRV-NLESPGPERV 205
A D ++ ++ LQ+LR S + AK +Q AA + R RV L+ ER
Sbjct: 1376 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1435
Query: 206 WRASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPL 265
+ GE QA RA + QA+ E + V +A L
Sbjct: 1436 RGGAEGELQAL---RARAEEAEAQKRQAQ-------EEAERLRRQVQDESQRKRQAEVEL 1485
Query: 266 SKAYQGVAAPFPKARRPESAL----LGGSEAGERLLQQGLAQVEAGRRQAEA--TRQAAA 319
+ + A + +R AL L EA RL Q A+VE R+ A T Q +A
Sbjct: 1486 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ---AEVERARQVQVALETAQRSA 1542
Query: 320 QEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEER-----ESAREEEEAEQERRGG 374
+ E + AS L+ ++ + L+E AE R E+ R EEAE+E
Sbjct: 1543 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL--- 1599
Query: 375 EERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEG 434
ER + EA +AEE A+Q +L AE AE ++ + E RR +AE
Sbjct: 1600 -ERWQLKANEALRLRLQAEEV--AQQKSLAQAE-------AEKQKEEAEREARRRGKAEE 1649
Query: 435 TEEGGEEEDDEEMDPQTIDSLIELSTKLHLPAD-DVVSIIEEVEEKRKRKKNAPPEPVPP 493
E ++E++ Q L E + + L A+ +++ + E E+ ++++ E
Sbjct: 1650 QAVRQRELAEQELEKQR--QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1707
Query: 494 PRAAPAPTHVR 504
R A A T R
Sbjct: 1708 QREAAAATQKR 1718
Score = 50.1 bits (118), Expect = 6e-06
Identities = 105/397 (26%), Positives = 149/397 (37%), Gaps = 67/397 (16%)
Query: 87 LQALDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPP-----RPQ 141
LQ L + + + ++Q E + + E +R L A E A R +
Sbjct: 1390 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1449
Query: 142 TPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQET-----------AAAETETRTH 190
E + EE E L +Q+ S KRQ E AA E +
Sbjct: 1450 AEEAEAQKRQAQEEAERLRRQVQD-----ESQRKRQAEVELASRVKAEAEAAREKQRALQ 1504
Query: 191 TLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEG 250
L + L++ ER R QA V ERA A Q R ++ + F E
Sbjct: 1505 ALEELRLQAEEAERRLR------QAEV-ERARQVQVALETAQ-RSAEAELQSKRASFAEK 1556
Query: 251 VSSPKTHLGE---ALAPLSKAYQGVAAPFPKARRPES---------------ALLGGSEA 292
+ + L E A+A L + + A +A R AL +A
Sbjct: 1557 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1616
Query: 293 GERLLQQGLAQVEAGRRQAEATRQAA--AQEERLADLASDLLLQYLLQGGARQRGLG-GR 349
E Q+ LAQ EA +++ EA R+A + E A +L Q L +QR L G
Sbjct: 1617 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL----EKQRQLAEGT 1672
Query: 350 GLQEAAEERESAR---EEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAE------RARQ 400
Q A E+E R E E+ EQ+R+ EE + EAA A + +E E RA
Sbjct: 1673 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1732
Query: 401 NALLF----AEEEDGEAGAEDKRSQEETPGHRRKEAE 433
LL AEEE + K+ E G R+ AE
Sbjct: 1733 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1769
Score = 49.3 bits (116), Expect = 1e-05
Identities = 56/198 (28%), Positives = 88/198 (44%), Gaps = 34/198 (17%)
Query: 267 KAYQGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLAD 326
+ + +AA AR+ ++AL E ERL A+VE RR E Q +A++ +LA
Sbjct: 1957 RVQKSLAAEEEAARQRKAAL----EEVERLK----AKVEEARRLRERAEQESARQLQLAQ 2008
Query: 327 LASDLLLQY---------------LLQGGARQRGLGGRGLQEAAEERESAREEEEAEQER 371
A+ LQ L Q +++ + + EA R +A E EEA
Sbjct: 2009 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-- 2066
Query: 372 RGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAE-EEDGEAGAEDKRSQEETPGHRRK 430
+ + EAA++ + EEAER +Q+A A+ +A AE R + E RR
Sbjct: 2067 --------QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2118
Query: 431 EAEGTEEGGEEEDDEEMD 448
+AE ++ D EM+
Sbjct: 2119 QAEQAALRQKQAADAEME 2136
Score = 48.9 bits (115), Expect = 1e-05
Identities = 81/345 (23%), Positives = 139/345 (40%), Gaps = 78/345 (22%)
Query: 295 RLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQ-YLLQGGARQRGLGGRGLQE 353
+ + + L ++E R AE +Q A + ERLA++ + L Q L + A+ + R +E
Sbjct: 1303 KFISETLRRMEEEERLAE--QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE 1360
Query: 354 AAE--ERESAREEE---EAEQERRGGEERVGE-EDEEAAEAEAEAEEAERARQNALLFAE 407
+ + E R EE +A+Q++R +E + + AE +A+A +AE A ++ L E
Sbjct: 1361 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1420
Query: 408 E-----------EDGEAGAED-----KRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQT 451
E E GAE + EE +R+ E E + DE +
Sbjct: 1421 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1480
Query: 452 IDSLIELSTKLHLPADDV------VSIIEEV----EEKRKRKKNAPPEPVPPPRAAPAPT 501
+ +EL++++ A+ + +EE+ EE +R + A E RA
Sbjct: 1481 AE--VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE-----RARQVQV 1533
Query: 502 HVRSPQPPPPAPAPARDELPDWNEVLPPWDREEDEVYPPGPYHPFPNYIRPRTLQPPSAL 561
+ + Q A A + + + E +T Q +L
Sbjct: 1534 ALETAQRS--AEAELQSKRASFAE---------------------------KTAQLERSL 1564
Query: 562 RRRHYHHALPPSRHYPGREAQARRAQEEAEAEERRLQEQEELENY 606
+ H A RE RRAQ++AEAE R + + ELE +
Sbjct: 1565 QEEHVAVAQL-------REEAERRAQQQAEAERAREEAERELERW 1602
Score = 47.8 bits (112), Expect = 3e-05
Identities = 86/398 (21%), Positives = 145/398 (36%), Gaps = 26/398 (6%)
Query: 90 LDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEA 149
L+ ASP Q G E E + T S+ +L + + R E
Sbjct: 1261 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1320
Query: 150 SDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWRAS 209
+EE E LA + L + Q A AE E + L+ E V R
Sbjct: 1321 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK-------ELQQRMQEEVVRRE 1373
Query: 210 WGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAY 269
A+ +R+ Q R + + E + + E + +
Sbjct: 1374 EAAVDAQQQKRSI----QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1429
Query: 270 QGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLAS 329
+ A AL +E E +Q + E RRQ + Q Q E +LAS
Sbjct: 1430 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE--VELAS 1487
Query: 330 DLLLQYLLQGGARQRGLGGRGLQEAAEERESA-REEEEAEQERRGGEERVGEEDEEAAEA 388
+ + AR++ + L+E + E A R +AE ER + E + +AEA
Sbjct: 1488 RVKAE---AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1544
Query: 389 EAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMD 448
E +++ A A + A L ++ R + E RR + + E EE + E++
Sbjct: 1545 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE----RRAQQQAEAERAREEAERELE 1600
Query: 449 PQTIDSLIELSTKLHLPADDVV---SIIEEVEEKRKRK 483
+ + + +L L A++V S+ + EK+K +
Sbjct: 1601 RWQLKA--NEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1636
Score = 47.8 bits (112), Expect = 3e-05
Identities = 100/423 (23%), Positives = 158/423 (37%), Gaps = 48/423 (11%)
Query: 53 DGSAPEVRGARNSEPQDEGELFQGVDPRALAAVLLQALDRPASPPAPSGSQQGPEEEAA- 111
+G+A + A + E QG R L L L R A+ A + +Q E E A
Sbjct: 1670 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA--AATQKRQELEAELAK 1727
Query: 112 -----EALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQEL 166
E LL R++ S E + E ++ + L ALA +
Sbjct: 1728 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQ 1784
Query: 167 RDFSPSSAKRQ---------QETAAAETETRTHTLTRVNLESPGPE--RVWRASWGE-FQ 214
R + A RQ ++ AA TR T + L+ E R+ R + E FQ
Sbjct: 1785 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1844
Query: 215 ARVPERAPLPPPAPSQ---FQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQG 271
R E A + Q R L E + + E + L +++
Sbjct: 1845 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1904
Query: 272 VAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDL 331
AA + + +E R +Q A++EA R+ RQ AA+EER A +
Sbjct: 1905 AAAGKAELELELGRIRSNAEDTLRSKEQ--AELEAARQ-----RQLAAEEERRRREAEER 1957
Query: 332 LLQYLL--QGGARQRGLGGRGLQEAAEERESAREEEEAEQERRGGEE--RVGEEDEEAAE 387
+ + L + ARQR L+E ER A+ EE R +E R + +EAA+
Sbjct: 1958 VQKSLAAEEEAARQRKAA---LEEV--ERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2012
Query: 388 AEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEM 447
+AEE A FA ++ + + + ++ R EAE EE ++ +
Sbjct: 2013 KRLQAEEKAHA------FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2066
Query: 448 DPQ 450
+
Sbjct: 2067 QAE 2069
Score = 46.6 bits (109), Expect = 7e-05
Identities = 63/249 (25%), Positives = 103/249 (41%), Gaps = 36/249 (14%)
Query: 174 AKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQA 233
A RQ++ AA E R ERV ++ E +A +A L + +A
Sbjct: 1937 AARQRQLAAEEERRRREA----------EERVQKSLAAEEEAARQRKAALEEV--ERLKA 1984
Query: 234 RMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAG 293
++ ++ L E E S+ + L + A + A F ++ E L +
Sbjct: 1985 KVEEARRLRER---AEQESARQLQLAQEAAQKRLQAEEKAHAFA-VQQKEQELQQTLQQE 2040
Query: 294 ERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQE 353
+ +L Q + EA RR AE +A Q ER A A+ R R ++E
Sbjct: 2041 QSVLDQLRGEAEAARRAAEEAEEARVQAEREA---------------AQSR----RQVEE 2081
Query: 354 AAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEA 413
A ++SA E+ +A + + E++ +E E+ A A+AE+A RQ AE E +
Sbjct: 2082 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA-ALRQKQAADAEMEKHKK 2140
Query: 414 GAEDKRSQE 422
AE Q+
Sbjct: 2141 FAEQTLRQK 2149
Score = 41.6 bits (96), Expect = 0.002
Identities = 54/168 (32%), Positives = 75/168 (44%), Gaps = 15/168 (8%)
Query: 278 KARRPESALLGGSEAGERLLQQGLAQVEAGRR-QAEATRQAAAQEERLADLASDLLLQYL 336
KA+ E+ L E Q LAQ A +R QAE A A +++ +L L +
Sbjct: 1983 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2042
Query: 337 LQGGARQRGLGGRGLQEAAEERESAR--EEEEAEQERRGGEE-----RVGEEDEEA-AEA 388
+ R R AAEE E AR E EA Q RR EE + EE +A A+A
Sbjct: 2043 VLDQLRGEAEAAR---RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2099
Query: 389 EAEAEEAER-ARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGT 435
+A AE+ + A Q A A+ E +A K++ + +K AE T
Sbjct: 2100 QAAAEKLRKEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQT 2145
Score = 38.5 bits (88), Expect = 0.018
Identities = 84/370 (22%), Positives = 140/370 (37%), Gaps = 56/370 (15%)
Query: 149 ASDPSEELEA-LASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWR 207
A+ +ELEA LA + E+ S A+ ++E+ + +++
Sbjct: 1714 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL---------------E 1758
Query: 208 ASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPK-THLGEALAPLS 266
A G F+ E A L A + R E V + K +GEA +
Sbjct: 1759 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1818
Query: 267 KAYQGVAAPFPKARRPESALLGGSEAGERL-LQQGLAQVEAG--RRQAEATRQAAAQEER 323
+A +A +A L EA +R L++ AQ +A R A+ + + ++ ER
Sbjct: 1819 EAE--IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1876
Query: 324 LADLASDLLLQ-------YLLQGGARQRGLGGRG--------LQEAAEERESAREEEEAE 368
L D L Q L + ++ G+ ++ AE+ ++E+ E E
Sbjct: 1877 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 1936
Query: 369 QERR----GGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAED-----KR 419
R+ EER E EE + AEE E ARQ E E +A E+ +R
Sbjct: 1937 AARQRQLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKVEEARRLRER 1995
Query: 420 SQEET---------PGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVV 470
+++E+ +R +AE + E+ QT+ + +L A+
Sbjct: 1996 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2055
Query: 471 SIIEEVEEKR 480
EE EE R
Sbjct: 2056 RAAEEAEEAR 2065
Score = 38.1 bits (87), Expect = 0.024
Identities = 71/289 (24%), Positives = 115/289 (39%), Gaps = 33/289 (11%)
Query: 148 EASDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWR 207
+A + L+A A LLQ+ ++ + A+R QE + E L E+ G +R
Sbjct: 2285 QAVQEATRLKAEAELLQQQKELAQEQARRLQE----DKEQMAQQLAE---ETQGFQRTLE 2337
Query: 208 ASWG---EFQARVPERAPLPPPAPSQFQARMPDSGPL--PETHKFGEGVSSPKTHLGEAL 262
A E A ER L S+ QAR + + + GE + + E +
Sbjct: 2338 AERQRQLEMSAEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2396
Query: 263 APLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQG-LAQVEAGRRQAEATRQAAAQE 321
+ A R A+ E+L Q+ L Q+++ Q Q +
Sbjct: 2397 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2456
Query: 322 ERLADL---ASDLLLQ---YLLQGGARQRGLGGRGLQEAAEERESA-REEEEAEQERRGG 374
+ L D LLQ ++ Q A+ L + +A + RE R++++ EQER
Sbjct: 2457 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER--- 2513
Query: 375 EERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEE 423
+R+ EEA + EAEE R +Q L E++ +R QEE
Sbjct: 2514 -QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ--------RRQQEE 2553
Score = 35.4 bits (80), Expect = 0.16
Identities = 85/376 (22%), Positives = 135/376 (35%), Gaps = 46/376 (12%)
Query: 243 ETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQGLA 302
E K + V + L A L K A P L G E GERL Q+
Sbjct: 1078 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR--- 1134
Query: 303 QVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQ-----EAAEE 357
G R E R ER+A L + L Q RQR L G Q E+A+
Sbjct: 1135 ---HGERDVEVER----WRERVAQLL-ERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1186
Query: 358 -----RESAREEEEAE----QERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEE 408
+++ R +E+ + + + E++ +E E E E+ E ++ A +
Sbjct: 1187 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1246
Query: 409 -EDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPAD 467
+D E ++Q E K+ + + G E E +D +T S EL+T
Sbjct: 1247 IKDYELQLVTYKAQLEPVASPAKKPK-VQSGSESVIQEYVDLRTHYS--ELTTL----TS 1299
Query: 468 DVVSIIEEVEEKRKRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVL 527
+ I E + + ++ + R A + A A A+ + E
Sbjct: 1300 QYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1359
Query: 528 PPWDREEDEVYPPGPYHPFPNYIRPRTLQPPSALRRRHYHHALPPSRHYPGREAQARRAQ 587
R ++EV +R + ++R L R E QA+ Q
Sbjct: 1360 ELQQRMQEEV------------VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1407
Query: 588 EEAEAEERRLQEQEEL 603
EA AE RL+ +EE+
Sbjct: 1408 AEA-AERSRLRIEEEI 1422
Score = 33.9 bits (76), Expect = 0.45
Identities = 36/118 (30%), Positives = 54/118 (45%), Gaps = 23/118 (19%)
Query: 294 ERLLQQGLAQVEAGRRQAEATRQAAAQE-ERLADLASDLLLQYLLQGGARQRGLGGRGLQ 352
E+L Q +A+ + R + + +Q QE +RL + AR+R Q
Sbjct: 2485 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE----------ARRR-------Q 2527
Query: 353 EAAEERESAREEE--EAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEE 408
AEE ++EE + EQ+RR EE + EE++ E EE RA AL +EE
Sbjct: 2528 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEE 2582
Score = 30.4 bits (67), Expect = 5.0
Identities = 79/386 (20%), Positives = 134/386 (34%), Gaps = 47/386 (12%)
Query: 120 RSQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQE 179
R++ S + + AA R Q E + +E E +L QE + +
Sbjct: 1995 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2054
Query: 180 TAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSG 239
AAE RV E + + +V E L A Q QAR
Sbjct: 2055 RRAAEEAEEA----RVQAEREAAQS---------RRQVEEAERLKQSAEEQAQARAQAQA 2101
Query: 240 PLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARR-PESALLGGSEAGERLL- 297
+ K E ++ + +A + Q A K ++ E L ++ + L
Sbjct: 2102 AAEKLRKEAEQEAARRAQAEQAAL---RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2158
Query: 298 ----------QQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLG 347
Q+ L E R +AEAT +AA Q ++ + + +Q + R
Sbjct: 2159 LRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR--- 2214
Query: 348 GRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNAL--LF 405
EA R+++ ++ + E++ + EEAA A+EA R RQ A L
Sbjct: 2215 ----IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2270
Query: 406 AEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGE---------EEDDEEMDPQTIDSLI 456
+ E ++K + + EAE ++ E +ED E+M Q +
Sbjct: 2271 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2330
Query: 457 ELSTKLHLPADDVVSIIEEVEEKRKR 482
L + + E E + R
Sbjct: 2331 GFQRTLEAERQRQLEMSAEAERLKLR 2356
Score = 29.6 bits (65), Expect = 8.5
Identities = 15/35 (42%), Positives = 22/35 (62%)
Query: 580 EAQARRAQEEAEAEERRLQEQEELENYIEHVLLRR 614
EAQ R+AQEEAE R++Q++ + + E L R
Sbjct: 1454 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1488
>gi|41322916 plectin 1 isoform 6 [Homo sapiens]
Length = 4684
Score = 56.6 bits (135), Expect = 7e-08
Identities = 98/371 (26%), Positives = 152/371 (40%), Gaps = 43/371 (11%)
Query: 149 ASDPSEELEALASLLQELRDFSPSS--AKRQQETAAAETETRTHTLTRV-NLESPGPERV 205
A D ++ ++ LQ+LR S + AK +Q AA + R RV L+ ER
Sbjct: 1545 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1604
Query: 206 WRASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPL 265
+ GE QA RA + QA+ E + V +A L
Sbjct: 1605 RGGAEGELQAL---RARAEEAEAQKRQAQ-------EEAERLRRQVQDESQRKRQAEVEL 1654
Query: 266 SKAYQGVAAPFPKARRPESAL----LGGSEAGERLLQQGLAQVEAGRRQAEA--TRQAAA 319
+ + A + +R AL L EA RL Q A+VE R+ A T Q +A
Sbjct: 1655 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ---AEVERARQVQVALETAQRSA 1711
Query: 320 QEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEER-----ESAREEEEAEQERRGG 374
+ E + AS L+ ++ + L+E AE R E+ R EEAE+E
Sbjct: 1712 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL--- 1768
Query: 375 EERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEG 434
ER + EA +AEE A+Q +L AE AE ++ + E RR +AE
Sbjct: 1769 -ERWQLKANEALRLRLQAEEV--AQQKSLAQAE-------AEKQKEEAEREARRRGKAEE 1818
Query: 435 TEEGGEEEDDEEMDPQTIDSLIELSTKLHLPAD-DVVSIIEEVEEKRKRKKNAPPEPVPP 493
E ++E++ Q L E + + L A+ +++ + E E+ ++++ E
Sbjct: 1819 QAVRQRELAEQELEKQR--QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1876
Query: 494 PRAAPAPTHVR 504
R A A T R
Sbjct: 1877 QREAAAATQKR 1887
Score = 50.1 bits (118), Expect = 6e-06
Identities = 105/397 (26%), Positives = 149/397 (37%), Gaps = 67/397 (16%)
Query: 87 LQALDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPP-----RPQ 141
LQ L + + + ++Q E + + E +R L A E A R +
Sbjct: 1559 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1618
Query: 142 TPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQET-----------AAAETETRTH 190
E + EE E L +Q+ S KRQ E AA E +
Sbjct: 1619 AEEAEAQKRQAQEEAERLRRQVQD-----ESQRKRQAEVELASRVKAEAEAAREKQRALQ 1673
Query: 191 TLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEG 250
L + L++ ER R QA V ERA A Q R ++ + F E
Sbjct: 1674 ALEELRLQAEEAERRLR------QAEV-ERARQVQVALETAQ-RSAEAELQSKRASFAEK 1725
Query: 251 VSSPKTHLGE---ALAPLSKAYQGVAAPFPKARRPES---------------ALLGGSEA 292
+ + L E A+A L + + A +A R AL +A
Sbjct: 1726 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1785
Query: 293 GERLLQQGLAQVEAGRRQAEATRQAA--AQEERLADLASDLLLQYLLQGGARQRGLG-GR 349
E Q+ LAQ EA +++ EA R+A + E A +L Q L +QR L G
Sbjct: 1786 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL----EKQRQLAEGT 1841
Query: 350 GLQEAAEERESAR---EEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAE------RARQ 400
Q A E+E R E E+ EQ+R+ EE + EAA A + +E E RA
Sbjct: 1842 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1901
Query: 401 NALLF----AEEEDGEAGAEDKRSQEETPGHRRKEAE 433
LL AEEE + K+ E G R+ AE
Sbjct: 1902 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1938
Score = 49.3 bits (116), Expect = 1e-05
Identities = 56/198 (28%), Positives = 88/198 (44%), Gaps = 34/198 (17%)
Query: 267 KAYQGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLAD 326
+ + +AA AR+ ++AL E ERL A+VE RR E Q +A++ +LA
Sbjct: 2126 RVQKSLAAEEEAARQRKAAL----EEVERLK----AKVEEARRLRERAEQESARQLQLAQ 2177
Query: 327 LASDLLLQY---------------LLQGGARQRGLGGRGLQEAAEERESAREEEEAEQER 371
A+ LQ L Q +++ + + EA R +A E EEA
Sbjct: 2178 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-- 2235
Query: 372 RGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAE-EEDGEAGAEDKRSQEETPGHRRK 430
+ + EAA++ + EEAER +Q+A A+ +A AE R + E RR
Sbjct: 2236 --------QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2287
Query: 431 EAEGTEEGGEEEDDEEMD 448
+AE ++ D EM+
Sbjct: 2288 QAEQAALRQKQAADAEME 2305
Score = 48.9 bits (115), Expect = 1e-05
Identities = 81/345 (23%), Positives = 139/345 (40%), Gaps = 78/345 (22%)
Query: 295 RLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQ-YLLQGGARQRGLGGRGLQE 353
+ + + L ++E R AE +Q A + ERLA++ + L Q L + A+ + R +E
Sbjct: 1472 KFISETLRRMEEEERLAE--QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE 1529
Query: 354 AAE--ERESAREEE---EAEQERRGGEERVGE-EDEEAAEAEAEAEEAERARQNALLFAE 407
+ + E R EE +A+Q++R +E + + AE +A+A +AE A ++ L E
Sbjct: 1530 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1589
Query: 408 E-----------EDGEAGAED-----KRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQT 451
E E GAE + EE +R+ E E + DE +
Sbjct: 1590 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1649
Query: 452 IDSLIELSTKLHLPADDV------VSIIEEV----EEKRKRKKNAPPEPVPPPRAAPAPT 501
+ +EL++++ A+ + +EE+ EE +R + A E RA
Sbjct: 1650 AE--VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE-----RARQVQV 1702
Query: 502 HVRSPQPPPPAPAPARDELPDWNEVLPPWDREEDEVYPPGPYHPFPNYIRPRTLQPPSAL 561
+ + Q A A + + + E +T Q +L
Sbjct: 1703 ALETAQRS--AEAELQSKRASFAE---------------------------KTAQLERSL 1733
Query: 562 RRRHYHHALPPSRHYPGREAQARRAQEEAEAEERRLQEQEELENY 606
+ H A RE RRAQ++AEAE R + + ELE +
Sbjct: 1734 QEEHVAVAQL-------REEAERRAQQQAEAERAREEAERELERW 1771
Score = 47.8 bits (112), Expect = 3e-05
Identities = 86/398 (21%), Positives = 145/398 (36%), Gaps = 26/398 (6%)
Query: 90 LDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEA 149
L+ ASP Q G E E + T S+ +L + + R E
Sbjct: 1430 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1489
Query: 150 SDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWRAS 209
+EE E LA + L + Q A AE E + L+ E V R
Sbjct: 1490 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK-------ELQQRMQEEVVRRE 1542
Query: 210 WGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAY 269
A+ +R+ Q R + + E + + E + +
Sbjct: 1543 EAAVDAQQQKRSI----QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1598
Query: 270 QGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLAS 329
+ A AL +E E +Q + E RRQ + Q Q E +LAS
Sbjct: 1599 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE--VELAS 1656
Query: 330 DLLLQYLLQGGARQRGLGGRGLQEAAEERESA-REEEEAEQERRGGEERVGEEDEEAAEA 388
+ + AR++ + L+E + E A R +AE ER + E + +AEA
Sbjct: 1657 RVKAE---AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1713
Query: 389 EAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMD 448
E +++ A A + A L ++ R + E RR + + E EE + E++
Sbjct: 1714 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE----RRAQQQAEAERAREEAERELE 1769
Query: 449 PQTIDSLIELSTKLHLPADDVV---SIIEEVEEKRKRK 483
+ + + +L L A++V S+ + EK+K +
Sbjct: 1770 RWQLKA--NEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1805
Score = 47.8 bits (112), Expect = 3e-05
Identities = 100/423 (23%), Positives = 158/423 (37%), Gaps = 48/423 (11%)
Query: 53 DGSAPEVRGARNSEPQDEGELFQGVDPRALAAVLLQALDRPASPPAPSGSQQGPEEEAA- 111
+G+A + A + E QG R L L L R A+ A + +Q E E A
Sbjct: 1839 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA--AATQKRQELEAELAK 1896
Query: 112 -----EALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQEL 166
E LL R++ S E + E ++ + L ALA +
Sbjct: 1897 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQ 1953
Query: 167 RDFSPSSAKRQ---------QETAAAETETRTHTLTRVNLESPGPE--RVWRASWGE-FQ 214
R + A RQ ++ AA TR T + L+ E R+ R + E FQ
Sbjct: 1954 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 2013
Query: 215 ARVPERAPLPPPAPSQ---FQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQG 271
R E A + Q R L E + + E + L +++
Sbjct: 2014 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 2073
Query: 272 VAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDL 331
AA + + +E R +Q A++EA R+ RQ AA+EER A +
Sbjct: 2074 AAAGKAELELELGRIRSNAEDTLRSKEQ--AELEAARQ-----RQLAAEEERRRREAEER 2126
Query: 332 LLQYLL--QGGARQRGLGGRGLQEAAEERESAREEEEAEQERRGGEE--RVGEEDEEAAE 387
+ + L + ARQR L+E ER A+ EE R +E R + +EAA+
Sbjct: 2127 VQKSLAAEEEAARQRKAA---LEEV--ERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2181
Query: 388 AEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEM 447
+AEE A FA ++ + + + ++ R EAE EE ++ +
Sbjct: 2182 KRLQAEEKAHA------FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2235
Query: 448 DPQ 450
+
Sbjct: 2236 QAE 2238
Score = 46.6 bits (109), Expect = 7e-05
Identities = 63/249 (25%), Positives = 103/249 (41%), Gaps = 36/249 (14%)
Query: 174 AKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQA 233
A RQ++ AA E R ERV ++ E +A +A L + +A
Sbjct: 2106 AARQRQLAAEEERRRREA----------EERVQKSLAAEEEAARQRKAALEEV--ERLKA 2153
Query: 234 RMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAG 293
++ ++ L E E S+ + L + A + A F ++ E L +
Sbjct: 2154 KVEEARRLRER---AEQESARQLQLAQEAAQKRLQAEEKAHAFA-VQQKEQELQQTLQQE 2209
Query: 294 ERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQE 353
+ +L Q + EA RR AE +A Q ER A A+ R R ++E
Sbjct: 2210 QSVLDQLRGEAEAARRAAEEAEEARVQAEREA---------------AQSR----RQVEE 2250
Query: 354 AAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEA 413
A ++SA E+ +A + + E++ +E E+ A A+AE+A RQ AE E +
Sbjct: 2251 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA-ALRQKQAADAEMEKHKK 2309
Query: 414 GAEDKRSQE 422
AE Q+
Sbjct: 2310 FAEQTLRQK 2318
Score = 41.6 bits (96), Expect = 0.002
Identities = 54/168 (32%), Positives = 75/168 (44%), Gaps = 15/168 (8%)
Query: 278 KARRPESALLGGSEAGERLLQQGLAQVEAGRR-QAEATRQAAAQEERLADLASDLLLQYL 336
KA+ E+ L E Q LAQ A +R QAE A A +++ +L L +
Sbjct: 2152 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2211
Query: 337 LQGGARQRGLGGRGLQEAAEERESAR--EEEEAEQERRGGEE-----RVGEEDEEA-AEA 388
+ R R AAEE E AR E EA Q RR EE + EE +A A+A
Sbjct: 2212 VLDQLRGEAEAAR---RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2268
Query: 389 EAEAEEAER-ARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGT 435
+A AE+ + A Q A A+ E +A K++ + +K AE T
Sbjct: 2269 QAAAEKLRKEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQT 2314
Score = 38.5 bits (88), Expect = 0.018
Identities = 84/370 (22%), Positives = 140/370 (37%), Gaps = 56/370 (15%)
Query: 149 ASDPSEELEA-LASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWR 207
A+ +ELEA LA + E+ S A+ ++E+ + +++
Sbjct: 1883 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL---------------E 1927
Query: 208 ASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPK-THLGEALAPLS 266
A G F+ E A L A + R E V + K +GEA +
Sbjct: 1928 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1987
Query: 267 KAYQGVAAPFPKARRPESALLGGSEAGERL-LQQGLAQVEAG--RRQAEATRQAAAQEER 323
+A +A +A L EA +R L++ AQ +A R A+ + + ++ ER
Sbjct: 1988 EAE--IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 2045
Query: 324 LADLASDLLLQ-------YLLQGGARQRGLGGRG--------LQEAAEERESAREEEEAE 368
L D L Q L + ++ G+ ++ AE+ ++E+ E E
Sbjct: 2046 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 2105
Query: 369 QERR----GGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAED-----KR 419
R+ EER E EE + AEE E ARQ E E +A E+ +R
Sbjct: 2106 AARQRQLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKVEEARRLRER 2164
Query: 420 SQEET---------PGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVV 470
+++E+ +R +AE + E+ QT+ + +L A+
Sbjct: 2165 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2224
Query: 471 SIIEEVEEKR 480
EE EE R
Sbjct: 2225 RAAEEAEEAR 2234
Score = 38.1 bits (87), Expect = 0.024
Identities = 71/289 (24%), Positives = 115/289 (39%), Gaps = 33/289 (11%)
Query: 148 EASDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWR 207
+A + L+A A LLQ+ ++ + A+R QE + E L E+ G +R
Sbjct: 2454 QAVQEATRLKAEAELLQQQKELAQEQARRLQE----DKEQMAQQLAE---ETQGFQRTLE 2506
Query: 208 ASWG---EFQARVPERAPLPPPAPSQFQARMPDSGPL--PETHKFGEGVSSPKTHLGEAL 262
A E A ER L S+ QAR + + + GE + + E +
Sbjct: 2507 AERQRQLEMSAEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2565
Query: 263 APLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQG-LAQVEAGRRQAEATRQAAAQE 321
+ A R A+ E+L Q+ L Q+++ Q Q +
Sbjct: 2566 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2625
Query: 322 ERLADL---ASDLLLQ---YLLQGGARQRGLGGRGLQEAAEERESA-REEEEAEQERRGG 374
+ L D LLQ ++ Q A+ L + +A + RE R++++ EQER
Sbjct: 2626 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER--- 2682
Query: 375 EERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEE 423
+R+ EEA + EAEE R +Q L E++ +R QEE
Sbjct: 2683 -QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ--------RRQQEE 2722
Score = 35.4 bits (80), Expect = 0.16
Identities = 85/376 (22%), Positives = 135/376 (35%), Gaps = 46/376 (12%)
Query: 243 ETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQGLA 302
E K + V + L A L K A P L G E GERL Q+
Sbjct: 1247 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR--- 1303
Query: 303 QVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQ-----EAAEE 357
G R E R ER+A L + L Q RQR L G Q E+A+
Sbjct: 1304 ---HGERDVEVER----WRERVAQLL-ERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1355
Query: 358 -----RESAREEEEAE----QERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEE 408
+++ R +E+ + + + E++ +E E E E+ E ++ A +
Sbjct: 1356 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1415
Query: 409 -EDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPAD 467
+D E ++Q E K+ + + G E E +D +T S EL+T
Sbjct: 1416 IKDYELQLVTYKAQLEPVASPAKKPK-VQSGSESVIQEYVDLRTHYS--ELTTL----TS 1468
Query: 468 DVVSIIEEVEEKRKRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVL 527
+ I E + + ++ + R A + A A A+ + E
Sbjct: 1469 QYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1528
Query: 528 PPWDREEDEVYPPGPYHPFPNYIRPRTLQPPSALRRRHYHHALPPSRHYPGREAQARRAQ 587
R ++EV +R + ++R L R E QA+ Q
Sbjct: 1529 ELQQRMQEEV------------VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1576
Query: 588 EEAEAEERRLQEQEEL 603
EA AE RL+ +EE+
Sbjct: 1577 AEA-AERSRLRIEEEI 1591
Score = 33.9 bits (76), Expect = 0.45
Identities = 36/118 (30%), Positives = 54/118 (45%), Gaps = 23/118 (19%)
Query: 294 ERLLQQGLAQVEAGRRQAEATRQAAAQE-ERLADLASDLLLQYLLQGGARQRGLGGRGLQ 352
E+L Q +A+ + R + + +Q QE +RL + AR+R Q
Sbjct: 2654 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE----------ARRR-------Q 2696
Query: 353 EAAEERESAREEE--EAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEE 408
AEE ++EE + EQ+RR EE + EE++ E EE RA AL +EE
Sbjct: 2697 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEE 2751
Score = 30.4 bits (67), Expect = 5.0
Identities = 79/386 (20%), Positives = 134/386 (34%), Gaps = 47/386 (12%)
Query: 120 RSQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQE 179
R++ S + + AA R Q E + +E E +L QE + +
Sbjct: 2164 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2223
Query: 180 TAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSG 239
AAE RV E + + +V E L A Q QAR
Sbjct: 2224 RRAAEEAEEA----RVQAEREAAQS---------RRQVEEAERLKQSAEEQAQARAQAQA 2270
Query: 240 PLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARR-PESALLGGSEAGERLL- 297
+ K E ++ + +A + Q A K ++ E L ++ + L
Sbjct: 2271 AAEKLRKEAEQEAARRAQAEQAAL---RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2327
Query: 298 ----------QQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLG 347
Q+ L E R +AEAT +AA Q ++ + + +Q + R
Sbjct: 2328 LRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR--- 2383
Query: 348 GRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNAL--LF 405
EA R+++ ++ + E++ + EEAA A+EA R RQ A L
Sbjct: 2384 ----IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2439
Query: 406 AEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGE---------EEDDEEMDPQTIDSLI 456
+ E ++K + + EAE ++ E +ED E+M Q +
Sbjct: 2440 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2499
Query: 457 ELSTKLHLPADDVVSIIEEVEEKRKR 482
L + + E E + R
Sbjct: 2500 GFQRTLEAERQRQLEMSAEAERLKLR 2525
Score = 29.6 bits (65), Expect = 8.5
Identities = 15/35 (42%), Positives = 22/35 (62%)
Query: 580 EAQARRAQEEAEAEERRLQEQEELENYIEHVLLRR 614
EAQ R+AQEEAE R++Q++ + + E L R
Sbjct: 1623 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1657
>gi|41322908 plectin 1 isoform 3 [Homo sapiens]
Length = 4525
Score = 56.6 bits (135), Expect = 7e-08
Identities = 98/371 (26%), Positives = 152/371 (40%), Gaps = 43/371 (11%)
Query: 149 ASDPSEELEALASLLQELRDFSPSS--AKRQQETAAAETETRTHTLTRV-NLESPGPERV 205
A D ++ ++ LQ+LR S + AK +Q AA + R RV L+ ER
Sbjct: 1386 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1445
Query: 206 WRASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPL 265
+ GE QA RA + QA+ E + V +A L
Sbjct: 1446 RGGAEGELQAL---RARAEEAEAQKRQAQ-------EEAERLRRQVQDESQRKRQAEVEL 1495
Query: 266 SKAYQGVAAPFPKARRPESAL----LGGSEAGERLLQQGLAQVEAGRRQAEA--TRQAAA 319
+ + A + +R AL L EA RL Q A+VE R+ A T Q +A
Sbjct: 1496 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ---AEVERARQVQVALETAQRSA 1552
Query: 320 QEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEER-----ESAREEEEAEQERRGG 374
+ E + AS L+ ++ + L+E AE R E+ R EEAE+E
Sbjct: 1553 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL--- 1609
Query: 375 EERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEG 434
ER + EA +AEE A+Q +L AE AE ++ + E RR +AE
Sbjct: 1610 -ERWQLKANEALRLRLQAEEV--AQQKSLAQAE-------AEKQKEEAEREARRRGKAEE 1659
Query: 435 TEEGGEEEDDEEMDPQTIDSLIELSTKLHLPAD-DVVSIIEEVEEKRKRKKNAPPEPVPP 493
E ++E++ Q L E + + L A+ +++ + E E+ ++++ E
Sbjct: 1660 QAVRQRELAEQELEKQR--QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1717
Query: 494 PRAAPAPTHVR 504
R A A T R
Sbjct: 1718 QREAAAATQKR 1728
Score = 50.1 bits (118), Expect = 6e-06
Identities = 105/397 (26%), Positives = 149/397 (37%), Gaps = 67/397 (16%)
Query: 87 LQALDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPP-----RPQ 141
LQ L + + + ++Q E + + E +R L A E A R +
Sbjct: 1400 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1459
Query: 142 TPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQET-----------AAAETETRTH 190
E + EE E L +Q+ S KRQ E AA E +
Sbjct: 1460 AEEAEAQKRQAQEEAERLRRQVQD-----ESQRKRQAEVELASRVKAEAEAAREKQRALQ 1514
Query: 191 TLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEG 250
L + L++ ER R QA V ERA A Q R ++ + F E
Sbjct: 1515 ALEELRLQAEEAERRLR------QAEV-ERARQVQVALETAQ-RSAEAELQSKRASFAEK 1566
Query: 251 VSSPKTHLGE---ALAPLSKAYQGVAAPFPKARRPES---------------ALLGGSEA 292
+ + L E A+A L + + A +A R AL +A
Sbjct: 1567 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1626
Query: 293 GERLLQQGLAQVEAGRRQAEATRQAA--AQEERLADLASDLLLQYLLQGGARQRGLG-GR 349
E Q+ LAQ EA +++ EA R+A + E A +L Q L +QR L G
Sbjct: 1627 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL----EKQRQLAEGT 1682
Query: 350 GLQEAAEERESAR---EEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAE------RARQ 400
Q A E+E R E E+ EQ+R+ EE + EAA A + +E E RA
Sbjct: 1683 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1742
Query: 401 NALLF----AEEEDGEAGAEDKRSQEETPGHRRKEAE 433
LL AEEE + K+ E G R+ AE
Sbjct: 1743 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1779
Score = 49.3 bits (116), Expect = 1e-05
Identities = 56/198 (28%), Positives = 88/198 (44%), Gaps = 34/198 (17%)
Query: 267 KAYQGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLAD 326
+ + +AA AR+ ++AL E ERL A+VE RR E Q +A++ +LA
Sbjct: 1967 RVQKSLAAEEEAARQRKAAL----EEVERLK----AKVEEARRLRERAEQESARQLQLAQ 2018
Query: 327 LASDLLLQY---------------LLQGGARQRGLGGRGLQEAAEERESAREEEEAEQER 371
A+ LQ L Q +++ + + EA R +A E EEA
Sbjct: 2019 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-- 2076
Query: 372 RGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAE-EEDGEAGAEDKRSQEETPGHRRK 430
+ + EAA++ + EEAER +Q+A A+ +A AE R + E RR
Sbjct: 2077 --------QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2128
Query: 431 EAEGTEEGGEEEDDEEMD 448
+AE ++ D EM+
Sbjct: 2129 QAEQAALRQKQAADAEME 2146
Score = 48.9 bits (115), Expect = 1e-05
Identities = 81/345 (23%), Positives = 139/345 (40%), Gaps = 78/345 (22%)
Query: 295 RLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQ-YLLQGGARQRGLGGRGLQE 353
+ + + L ++E R AE +Q A + ERLA++ + L Q L + A+ + R +E
Sbjct: 1313 KFISETLRRMEEEERLAE--QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE 1370
Query: 354 AAE--ERESAREEE---EAEQERRGGEERVGE-EDEEAAEAEAEAEEAERARQNALLFAE 407
+ + E R EE +A+Q++R +E + + AE +A+A +AE A ++ L E
Sbjct: 1371 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1430
Query: 408 E-----------EDGEAGAED-----KRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQT 451
E E GAE + EE +R+ E E + DE +
Sbjct: 1431 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1490
Query: 452 IDSLIELSTKLHLPADDV------VSIIEEV----EEKRKRKKNAPPEPVPPPRAAPAPT 501
+ +EL++++ A+ + +EE+ EE +R + A E RA
Sbjct: 1491 AE--VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE-----RARQVQV 1543
Query: 502 HVRSPQPPPPAPAPARDELPDWNEVLPPWDREEDEVYPPGPYHPFPNYIRPRTLQPPSAL 561
+ + Q A A + + + E +T Q +L
Sbjct: 1544 ALETAQRS--AEAELQSKRASFAE---------------------------KTAQLERSL 1574
Query: 562 RRRHYHHALPPSRHYPGREAQARRAQEEAEAEERRLQEQEELENY 606
+ H A RE RRAQ++AEAE R + + ELE +
Sbjct: 1575 QEEHVAVAQL-------REEAERRAQQQAEAERAREEAERELERW 1612
Score = 47.8 bits (112), Expect = 3e-05
Identities = 86/398 (21%), Positives = 145/398 (36%), Gaps = 26/398 (6%)
Query: 90 LDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEA 149
L+ ASP Q G E E + T S+ +L + + R E
Sbjct: 1271 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1330
Query: 150 SDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWRAS 209
+EE E LA + L + Q A AE E + L+ E V R
Sbjct: 1331 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK-------ELQQRMQEEVVRRE 1383
Query: 210 WGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAY 269
A+ +R+ Q R + + E + + E + +
Sbjct: 1384 EAAVDAQQQKRSI----QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1439
Query: 270 QGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLAS 329
+ A AL +E E +Q + E RRQ + Q Q E +LAS
Sbjct: 1440 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE--VELAS 1497
Query: 330 DLLLQYLLQGGARQRGLGGRGLQEAAEERESA-REEEEAEQERRGGEERVGEEDEEAAEA 388
+ + AR++ + L+E + E A R +AE ER + E + +AEA
Sbjct: 1498 RVKAE---AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1554
Query: 389 EAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMD 448
E +++ A A + A L ++ R + E RR + + E EE + E++
Sbjct: 1555 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE----RRAQQQAEAERAREEAERELE 1610
Query: 449 PQTIDSLIELSTKLHLPADDVV---SIIEEVEEKRKRK 483
+ + + +L L A++V S+ + EK+K +
Sbjct: 1611 RWQLKA--NEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1646
Score = 47.8 bits (112), Expect = 3e-05
Identities = 100/423 (23%), Positives = 158/423 (37%), Gaps = 48/423 (11%)
Query: 53 DGSAPEVRGARNSEPQDEGELFQGVDPRALAAVLLQALDRPASPPAPSGSQQGPEEEAA- 111
+G+A + A + E QG R L L L R A+ A + +Q E E A
Sbjct: 1680 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA--AATQKRQELEAELAK 1737
Query: 112 -----EALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQEL 166
E LL R++ S E + E ++ + L ALA +
Sbjct: 1738 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQ 1794
Query: 167 RDFSPSSAKRQ---------QETAAAETETRTHTLTRVNLESPGPE--RVWRASWGE-FQ 214
R + A RQ ++ AA TR T + L+ E R+ R + E FQ
Sbjct: 1795 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1854
Query: 215 ARVPERAPLPPPAPSQ---FQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQG 271
R E A + Q R L E + + E + L +++
Sbjct: 1855 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1914
Query: 272 VAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDL 331
AA + + +E R +Q A++EA R+ RQ AA+EER A +
Sbjct: 1915 AAAGKAELELELGRIRSNAEDTLRSKEQ--AELEAARQ-----RQLAAEEERRRREAEER 1967
Query: 332 LLQYLL--QGGARQRGLGGRGLQEAAEERESAREEEEAEQERRGGEE--RVGEEDEEAAE 387
+ + L + ARQR L+E ER A+ EE R +E R + +EAA+
Sbjct: 1968 VQKSLAAEEEAARQRKAA---LEEV--ERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2022
Query: 388 AEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEM 447
+AEE A FA ++ + + + ++ R EAE EE ++ +
Sbjct: 2023 KRLQAEEKAHA------FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2076
Query: 448 DPQ 450
+
Sbjct: 2077 QAE 2079
Score = 46.6 bits (109), Expect = 7e-05
Identities = 63/249 (25%), Positives = 103/249 (41%), Gaps = 36/249 (14%)
Query: 174 AKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQA 233
A RQ++ AA E R ERV ++ E +A +A L + +A
Sbjct: 1947 AARQRQLAAEEERRRREA----------EERVQKSLAAEEEAARQRKAALEEV--ERLKA 1994
Query: 234 RMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAG 293
++ ++ L E E S+ + L + A + A F ++ E L +
Sbjct: 1995 KVEEARRLRER---AEQESARQLQLAQEAAQKRLQAEEKAHAFA-VQQKEQELQQTLQQE 2050
Query: 294 ERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQE 353
+ +L Q + EA RR AE +A Q ER A A+ R R ++E
Sbjct: 2051 QSVLDQLRGEAEAARRAAEEAEEARVQAEREA---------------AQSR----RQVEE 2091
Query: 354 AAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEA 413
A ++SA E+ +A + + E++ +E E+ A A+AE+A RQ AE E +
Sbjct: 2092 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA-ALRQKQAADAEMEKHKK 2150
Query: 414 GAEDKRSQE 422
AE Q+
Sbjct: 2151 FAEQTLRQK 2159
Score = 41.6 bits (96), Expect = 0.002
Identities = 54/168 (32%), Positives = 75/168 (44%), Gaps = 15/168 (8%)
Query: 278 KARRPESALLGGSEAGERLLQQGLAQVEAGRR-QAEATRQAAAQEERLADLASDLLLQYL 336
KA+ E+ L E Q LAQ A +R QAE A A +++ +L L +
Sbjct: 1993 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2052
Query: 337 LQGGARQRGLGGRGLQEAAEERESAR--EEEEAEQERRGGEE-----RVGEEDEEA-AEA 388
+ R R AAEE E AR E EA Q RR EE + EE +A A+A
Sbjct: 2053 VLDQLRGEAEAAR---RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2109
Query: 389 EAEAEEAER-ARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGT 435
+A AE+ + A Q A A+ E +A K++ + +K AE T
Sbjct: 2110 QAAAEKLRKEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQT 2155
Score = 38.5 bits (88), Expect = 0.018
Identities = 84/370 (22%), Positives = 140/370 (37%), Gaps = 56/370 (15%)
Query: 149 ASDPSEELEA-LASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWR 207
A+ +ELEA LA + E+ S A+ ++E+ + +++
Sbjct: 1724 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL---------------E 1768
Query: 208 ASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPK-THLGEALAPLS 266
A G F+ E A L A + R E V + K +GEA +
Sbjct: 1769 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1828
Query: 267 KAYQGVAAPFPKARRPESALLGGSEAGERL-LQQGLAQVEAG--RRQAEATRQAAAQEER 323
+A +A +A L EA +R L++ AQ +A R A+ + + ++ ER
Sbjct: 1829 EAE--IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1886
Query: 324 LADLASDLLLQ-------YLLQGGARQRGLGGRG--------LQEAAEERESAREEEEAE 368
L D L Q L + ++ G+ ++ AE+ ++E+ E E
Sbjct: 1887 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 1946
Query: 369 QERR----GGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAED-----KR 419
R+ EER E EE + AEE E ARQ E E +A E+ +R
Sbjct: 1947 AARQRQLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKVEEARRLRER 2005
Query: 420 SQEET---------PGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVV 470
+++E+ +R +AE + E+ QT+ + +L A+
Sbjct: 2006 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2065
Query: 471 SIIEEVEEKR 480
EE EE R
Sbjct: 2066 RAAEEAEEAR 2075
Score = 38.1 bits (87), Expect = 0.024
Identities = 71/289 (24%), Positives = 115/289 (39%), Gaps = 33/289 (11%)
Query: 148 EASDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWR 207
+A + L+A A LLQ+ ++ + A+R QE + E L E+ G +R
Sbjct: 2295 QAVQEATRLKAEAELLQQQKELAQEQARRLQE----DKEQMAQQLAE---ETQGFQRTLE 2347
Query: 208 ASWG---EFQARVPERAPLPPPAPSQFQARMPDSGPL--PETHKFGEGVSSPKTHLGEAL 262
A E A ER L S+ QAR + + + GE + + E +
Sbjct: 2348 AERQRQLEMSAEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2406
Query: 263 APLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQG-LAQVEAGRRQAEATRQAAAQE 321
+ A R A+ E+L Q+ L Q+++ Q Q +
Sbjct: 2407 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2466
Query: 322 ERLADL---ASDLLLQ---YLLQGGARQRGLGGRGLQEAAEERESA-REEEEAEQERRGG 374
+ L D LLQ ++ Q A+ L + +A + RE R++++ EQER
Sbjct: 2467 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER--- 2523
Query: 375 EERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEE 423
+R+ EEA + EAEE R +Q L E++ +R QEE
Sbjct: 2524 -QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ--------RRQQEE 2563
Score = 35.4 bits (80), Expect = 0.16
Identities = 85/376 (22%), Positives = 135/376 (35%), Gaps = 46/376 (12%)
Query: 243 ETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQGLA 302
E K + V + L A L K A P L G E GERL Q+
Sbjct: 1088 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR--- 1144
Query: 303 QVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQ-----EAAEE 357
G R E R ER+A L + L Q RQR L G Q E+A+
Sbjct: 1145 ---HGERDVEVER----WRERVAQLL-ERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1196
Query: 358 -----RESAREEEEAE----QERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEE 408
+++ R +E+ + + + E++ +E E E E+ E ++ A +
Sbjct: 1197 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1256
Query: 409 -EDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPAD 467
+D E ++Q E K+ + + G E E +D +T S EL+T
Sbjct: 1257 IKDYELQLVTYKAQLEPVASPAKKPK-VQSGSESVIQEYVDLRTHYS--ELTTL----TS 1309
Query: 468 DVVSIIEEVEEKRKRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVL 527
+ I E + + ++ + R A + A A A+ + E
Sbjct: 1310 QYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1369
Query: 528 PPWDREEDEVYPPGPYHPFPNYIRPRTLQPPSALRRRHYHHALPPSRHYPGREAQARRAQ 587
R ++EV +R + ++R L R E QA+ Q
Sbjct: 1370 ELQQRMQEEV------------VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1417
Query: 588 EEAEAEERRLQEQEEL 603
EA AE RL+ +EE+
Sbjct: 1418 AEA-AERSRLRIEEEI 1432
Score = 33.9 bits (76), Expect = 0.45
Identities = 36/118 (30%), Positives = 54/118 (45%), Gaps = 23/118 (19%)
Query: 294 ERLLQQGLAQVEAGRRQAEATRQAAAQE-ERLADLASDLLLQYLLQGGARQRGLGGRGLQ 352
E+L Q +A+ + R + + +Q QE +RL + AR+R Q
Sbjct: 2495 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE----------ARRR-------Q 2537
Query: 353 EAAEERESAREEE--EAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEE 408
AEE ++EE + EQ+RR EE + EE++ E EE RA AL +EE
Sbjct: 2538 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEE 2592
Score = 30.4 bits (67), Expect = 5.0
Identities = 79/386 (20%), Positives = 134/386 (34%), Gaps = 47/386 (12%)
Query: 120 RSQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQE 179
R++ S + + AA R Q E + +E E +L QE + +
Sbjct: 2005 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2064
Query: 180 TAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSG 239
AAE RV E + + +V E L A Q QAR
Sbjct: 2065 RRAAEEAEEA----RVQAEREAAQS---------RRQVEEAERLKQSAEEQAQARAQAQA 2111
Query: 240 PLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARR-PESALLGGSEAGERLL- 297
+ K E ++ + +A + Q A K ++ E L ++ + L
Sbjct: 2112 AAEKLRKEAEQEAARRAQAEQAAL---RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2168
Query: 298 ----------QQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLG 347
Q+ L E R +AEAT +AA Q ++ + + +Q + R
Sbjct: 2169 LRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR--- 2224
Query: 348 GRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNAL--LF 405
EA R+++ ++ + E++ + EEAA A+EA R RQ A L
Sbjct: 2225 ----IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2280
Query: 406 AEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGE---------EEDDEEMDPQTIDSLI 456
+ E ++K + + EAE ++ E +ED E+M Q +
Sbjct: 2281 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2340
Query: 457 ELSTKLHLPADDVVSIIEEVEEKRKR 482
L + + E E + R
Sbjct: 2341 GFQRTLEAERQRQLEMSAEAERLKLR 2366
Score = 29.6 bits (65), Expect = 8.5
Identities = 15/35 (42%), Positives = 22/35 (62%)
Query: 580 EAQARRAQEEAEAEERRLQEQEELENYIEHVLLRR 614
EAQ R+AQEEAE R++Q++ + + E L R
Sbjct: 1464 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1498
>gi|41322912 plectin 1 isoform 2 [Homo sapiens]
Length = 4533
Score = 56.6 bits (135), Expect = 7e-08
Identities = 98/371 (26%), Positives = 152/371 (40%), Gaps = 43/371 (11%)
Query: 149 ASDPSEELEALASLLQELRDFSPSS--AKRQQETAAAETETRTHTLTRV-NLESPGPERV 205
A D ++ ++ LQ+LR S + AK +Q AA + R RV L+ ER
Sbjct: 1394 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1453
Query: 206 WRASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPL 265
+ GE QA RA + QA+ E + V +A L
Sbjct: 1454 RGGAEGELQAL---RARAEEAEAQKRQAQ-------EEAERLRRQVQDESQRKRQAEVEL 1503
Query: 266 SKAYQGVAAPFPKARRPESAL----LGGSEAGERLLQQGLAQVEAGRRQAEA--TRQAAA 319
+ + A + +R AL L EA RL Q A+VE R+ A T Q +A
Sbjct: 1504 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ---AEVERARQVQVALETAQRSA 1560
Query: 320 QEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEER-----ESAREEEEAEQERRGG 374
+ E + AS L+ ++ + L+E AE R E+ R EEAE+E
Sbjct: 1561 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL--- 1617
Query: 375 EERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEG 434
ER + EA +AEE A+Q +L AE AE ++ + E RR +AE
Sbjct: 1618 -ERWQLKANEALRLRLQAEEV--AQQKSLAQAE-------AEKQKEEAEREARRRGKAEE 1667
Query: 435 TEEGGEEEDDEEMDPQTIDSLIELSTKLHLPAD-DVVSIIEEVEEKRKRKKNAPPEPVPP 493
E ++E++ Q L E + + L A+ +++ + E E+ ++++ E
Sbjct: 1668 QAVRQRELAEQELEKQR--QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1725
Query: 494 PRAAPAPTHVR 504
R A A T R
Sbjct: 1726 QREAAAATQKR 1736
Score = 50.1 bits (118), Expect = 6e-06
Identities = 105/397 (26%), Positives = 149/397 (37%), Gaps = 67/397 (16%)
Query: 87 LQALDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPP-----RPQ 141
LQ L + + + ++Q E + + E +R L A E A R +
Sbjct: 1408 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1467
Query: 142 TPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQET-----------AAAETETRTH 190
E + EE E L +Q+ S KRQ E AA E +
Sbjct: 1468 AEEAEAQKRQAQEEAERLRRQVQD-----ESQRKRQAEVELASRVKAEAEAAREKQRALQ 1522
Query: 191 TLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEG 250
L + L++ ER R QA V ERA A Q R ++ + F E
Sbjct: 1523 ALEELRLQAEEAERRLR------QAEV-ERARQVQVALETAQ-RSAEAELQSKRASFAEK 1574
Query: 251 VSSPKTHLGE---ALAPLSKAYQGVAAPFPKARRPES---------------ALLGGSEA 292
+ + L E A+A L + + A +A R AL +A
Sbjct: 1575 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1634
Query: 293 GERLLQQGLAQVEAGRRQAEATRQAA--AQEERLADLASDLLLQYLLQGGARQRGLG-GR 349
E Q+ LAQ EA +++ EA R+A + E A +L Q L +QR L G
Sbjct: 1635 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL----EKQRQLAEGT 1690
Query: 350 GLQEAAEERESAR---EEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAE------RARQ 400
Q A E+E R E E+ EQ+R+ EE + EAA A + +E E RA
Sbjct: 1691 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1750
Query: 401 NALLF----AEEEDGEAGAEDKRSQEETPGHRRKEAE 433
LL AEEE + K+ E G R+ AE
Sbjct: 1751 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1787
Score = 49.3 bits (116), Expect = 1e-05
Identities = 56/198 (28%), Positives = 88/198 (44%), Gaps = 34/198 (17%)
Query: 267 KAYQGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLAD 326
+ + +AA AR+ ++AL E ERL A+VE RR E Q +A++ +LA
Sbjct: 1975 RVQKSLAAEEEAARQRKAAL----EEVERLK----AKVEEARRLRERAEQESARQLQLAQ 2026
Query: 327 LASDLLLQY---------------LLQGGARQRGLGGRGLQEAAEERESAREEEEAEQER 371
A+ LQ L Q +++ + + EA R +A E EEA
Sbjct: 2027 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-- 2084
Query: 372 RGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAE-EEDGEAGAEDKRSQEETPGHRRK 430
+ + EAA++ + EEAER +Q+A A+ +A AE R + E RR
Sbjct: 2085 --------QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2136
Query: 431 EAEGTEEGGEEEDDEEMD 448
+AE ++ D EM+
Sbjct: 2137 QAEQAALRQKQAADAEME 2154
Score = 48.9 bits (115), Expect = 1e-05
Identities = 81/345 (23%), Positives = 139/345 (40%), Gaps = 78/345 (22%)
Query: 295 RLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQ-YLLQGGARQRGLGGRGLQE 353
+ + + L ++E R AE +Q A + ERLA++ + L Q L + A+ + R +E
Sbjct: 1321 KFISETLRRMEEEERLAE--QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE 1378
Query: 354 AAE--ERESAREEE---EAEQERRGGEERVGE-EDEEAAEAEAEAEEAERARQNALLFAE 407
+ + E R EE +A+Q++R +E + + AE +A+A +AE A ++ L E
Sbjct: 1379 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1438
Query: 408 E-----------EDGEAGAED-----KRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQT 451
E E GAE + EE +R+ E E + DE +
Sbjct: 1439 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1498
Query: 452 IDSLIELSTKLHLPADDV------VSIIEEV----EEKRKRKKNAPPEPVPPPRAAPAPT 501
+ +EL++++ A+ + +EE+ EE +R + A E RA
Sbjct: 1499 AE--VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE-----RARQVQV 1551
Query: 502 HVRSPQPPPPAPAPARDELPDWNEVLPPWDREEDEVYPPGPYHPFPNYIRPRTLQPPSAL 561
+ + Q A A + + + E +T Q +L
Sbjct: 1552 ALETAQRS--AEAELQSKRASFAE---------------------------KTAQLERSL 1582
Query: 562 RRRHYHHALPPSRHYPGREAQARRAQEEAEAEERRLQEQEELENY 606
+ H A RE RRAQ++AEAE R + + ELE +
Sbjct: 1583 QEEHVAVAQL-------REEAERRAQQQAEAERAREEAERELERW 1620
Score = 47.8 bits (112), Expect = 3e-05
Identities = 86/398 (21%), Positives = 145/398 (36%), Gaps = 26/398 (6%)
Query: 90 LDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEA 149
L+ ASP Q G E E + T S+ +L + + R E
Sbjct: 1279 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1338
Query: 150 SDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWRAS 209
+EE E LA + L + Q A AE E + L+ E V R
Sbjct: 1339 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK-------ELQQRMQEEVVRRE 1391
Query: 210 WGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAY 269
A+ +R+ Q R + + E + + E + +
Sbjct: 1392 EAAVDAQQQKRSI----QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1447
Query: 270 QGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLAS 329
+ A AL +E E +Q + E RRQ + Q Q E +LAS
Sbjct: 1448 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE--VELAS 1505
Query: 330 DLLLQYLLQGGARQRGLGGRGLQEAAEERESA-REEEEAEQERRGGEERVGEEDEEAAEA 388
+ + AR++ + L+E + E A R +AE ER + E + +AEA
Sbjct: 1506 RVKAE---AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1562
Query: 389 EAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMD 448
E +++ A A + A L ++ R + E RR + + E EE + E++
Sbjct: 1563 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE----RRAQQQAEAERAREEAERELE 1618
Query: 449 PQTIDSLIELSTKLHLPADDVV---SIIEEVEEKRKRK 483
+ + + +L L A++V S+ + EK+K +
Sbjct: 1619 RWQLKA--NEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1654
Score = 47.8 bits (112), Expect = 3e-05
Identities = 100/423 (23%), Positives = 158/423 (37%), Gaps = 48/423 (11%)
Query: 53 DGSAPEVRGARNSEPQDEGELFQGVDPRALAAVLLQALDRPASPPAPSGSQQGPEEEAA- 111
+G+A + A + E QG R L L L R A+ A + +Q E E A
Sbjct: 1688 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA--AATQKRQELEAELAK 1745
Query: 112 -----EALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQEL 166
E LL R++ S E + E ++ + L ALA +
Sbjct: 1746 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQ 1802
Query: 167 RDFSPSSAKRQ---------QETAAAETETRTHTLTRVNLESPGPE--RVWRASWGE-FQ 214
R + A RQ ++ AA TR T + L+ E R+ R + E FQ
Sbjct: 1803 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1862
Query: 215 ARVPERAPLPPPAPSQ---FQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQG 271
R E A + Q R L E + + E + L +++
Sbjct: 1863 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1922
Query: 272 VAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDL 331
AA + + +E R +Q A++EA R+ RQ AA+EER A +
Sbjct: 1923 AAAGKAELELELGRIRSNAEDTLRSKEQ--AELEAARQ-----RQLAAEEERRRREAEER 1975
Query: 332 LLQYLL--QGGARQRGLGGRGLQEAAEERESAREEEEAEQERRGGEE--RVGEEDEEAAE 387
+ + L + ARQR L+E ER A+ EE R +E R + +EAA+
Sbjct: 1976 VQKSLAAEEEAARQRKAA---LEEV--ERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2030
Query: 388 AEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEM 447
+AEE A FA ++ + + + ++ R EAE EE ++ +
Sbjct: 2031 KRLQAEEKAHA------FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2084
Query: 448 DPQ 450
+
Sbjct: 2085 QAE 2087
Score = 46.6 bits (109), Expect = 7e-05
Identities = 63/249 (25%), Positives = 103/249 (41%), Gaps = 36/249 (14%)
Query: 174 AKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQA 233
A RQ++ AA E R ERV ++ E +A +A L + +A
Sbjct: 1955 AARQRQLAAEEERRRREA----------EERVQKSLAAEEEAARQRKAALEEV--ERLKA 2002
Query: 234 RMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAG 293
++ ++ L E E S+ + L + A + A F ++ E L +
Sbjct: 2003 KVEEARRLRER---AEQESARQLQLAQEAAQKRLQAEEKAHAFA-VQQKEQELQQTLQQE 2058
Query: 294 ERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQE 353
+ +L Q + EA RR AE +A Q ER A A+ R R ++E
Sbjct: 2059 QSVLDQLRGEAEAARRAAEEAEEARVQAEREA---------------AQSR----RQVEE 2099
Query: 354 AAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEA 413
A ++SA E+ +A + + E++ +E E+ A A+AE+A RQ AE E +
Sbjct: 2100 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA-ALRQKQAADAEMEKHKK 2158
Query: 414 GAEDKRSQE 422
AE Q+
Sbjct: 2159 FAEQTLRQK 2167
Score = 41.6 bits (96), Expect = 0.002
Identities = 54/168 (32%), Positives = 75/168 (44%), Gaps = 15/168 (8%)
Query: 278 KARRPESALLGGSEAGERLLQQGLAQVEAGRR-QAEATRQAAAQEERLADLASDLLLQYL 336
KA+ E+ L E Q LAQ A +R QAE A A +++ +L L +
Sbjct: 2001 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2060
Query: 337 LQGGARQRGLGGRGLQEAAEERESAR--EEEEAEQERRGGEE-----RVGEEDEEA-AEA 388
+ R R AAEE E AR E EA Q RR EE + EE +A A+A
Sbjct: 2061 VLDQLRGEAEAAR---RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2117
Query: 389 EAEAEEAER-ARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGT 435
+A AE+ + A Q A A+ E +A K++ + +K AE T
Sbjct: 2118 QAAAEKLRKEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQT 2163
Score = 38.5 bits (88), Expect = 0.018
Identities = 84/370 (22%), Positives = 140/370 (37%), Gaps = 56/370 (15%)
Query: 149 ASDPSEELEA-LASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWR 207
A+ +ELEA LA + E+ S A+ ++E+ + +++
Sbjct: 1732 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL---------------E 1776
Query: 208 ASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPK-THLGEALAPLS 266
A G F+ E A L A + R E V + K +GEA +
Sbjct: 1777 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1836
Query: 267 KAYQGVAAPFPKARRPESALLGGSEAGERL-LQQGLAQVEAG--RRQAEATRQAAAQEER 323
+A +A +A L EA +R L++ AQ +A R A+ + + ++ ER
Sbjct: 1837 EAE--IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1894
Query: 324 LADLASDLLLQ-------YLLQGGARQRGLGGRG--------LQEAAEERESAREEEEAE 368
L D L Q L + ++ G+ ++ AE+ ++E+ E E
Sbjct: 1895 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 1954
Query: 369 QERR----GGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAED-----KR 419
R+ EER E EE + AEE E ARQ E E +A E+ +R
Sbjct: 1955 AARQRQLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKVEEARRLRER 2013
Query: 420 SQEET---------PGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVV 470
+++E+ +R +AE + E+ QT+ + +L A+
Sbjct: 2014 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2073
Query: 471 SIIEEVEEKR 480
EE EE R
Sbjct: 2074 RAAEEAEEAR 2083
Score = 38.1 bits (87), Expect = 0.024
Identities = 71/289 (24%), Positives = 115/289 (39%), Gaps = 33/289 (11%)
Query: 148 EASDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWR 207
+A + L+A A LLQ+ ++ + A+R QE + E L E+ G +R
Sbjct: 2303 QAVQEATRLKAEAELLQQQKELAQEQARRLQE----DKEQMAQQLAE---ETQGFQRTLE 2355
Query: 208 ASWG---EFQARVPERAPLPPPAPSQFQARMPDSGPL--PETHKFGEGVSSPKTHLGEAL 262
A E A ER L S+ QAR + + + GE + + E +
Sbjct: 2356 AERQRQLEMSAEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2414
Query: 263 APLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQG-LAQVEAGRRQAEATRQAAAQE 321
+ A R A+ E+L Q+ L Q+++ Q Q +
Sbjct: 2415 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2474
Query: 322 ERLADL---ASDLLLQ---YLLQGGARQRGLGGRGLQEAAEERESA-REEEEAEQERRGG 374
+ L D LLQ ++ Q A+ L + +A + RE R++++ EQER
Sbjct: 2475 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER--- 2531
Query: 375 EERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEE 423
+R+ EEA + EAEE R +Q L E++ +R QEE
Sbjct: 2532 -QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ--------RRQQEE 2571
Score = 35.4 bits (80), Expect = 0.16
Identities = 85/376 (22%), Positives = 135/376 (35%), Gaps = 46/376 (12%)
Query: 243 ETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQGLA 302
E K + V + L A L K A P L G E GERL Q+
Sbjct: 1096 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR--- 1152
Query: 303 QVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQ-----EAAEE 357
G R E R ER+A L + L Q RQR L G Q E+A+
Sbjct: 1153 ---HGERDVEVER----WRERVAQLL-ERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1204
Query: 358 -----RESAREEEEAE----QERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEE 408
+++ R +E+ + + + E++ +E E E E+ E ++ A +
Sbjct: 1205 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1264
Query: 409 -EDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPAD 467
+D E ++Q E K+ + + G E E +D +T S EL+T
Sbjct: 1265 IKDYELQLVTYKAQLEPVASPAKKPK-VQSGSESVIQEYVDLRTHYS--ELTTL----TS 1317
Query: 468 DVVSIIEEVEEKRKRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVL 527
+ I E + + ++ + R A + A A A+ + E
Sbjct: 1318 QYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1377
Query: 528 PPWDREEDEVYPPGPYHPFPNYIRPRTLQPPSALRRRHYHHALPPSRHYPGREAQARRAQ 587
R ++EV +R + ++R L R E QA+ Q
Sbjct: 1378 ELQQRMQEEV------------VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1425
Query: 588 EEAEAEERRLQEQEEL 603
EA AE RL+ +EE+
Sbjct: 1426 AEA-AERSRLRIEEEI 1440
Score = 33.9 bits (76), Expect = 0.45
Identities = 36/118 (30%), Positives = 54/118 (45%), Gaps = 23/118 (19%)
Query: 294 ERLLQQGLAQVEAGRRQAEATRQAAAQE-ERLADLASDLLLQYLLQGGARQRGLGGRGLQ 352
E+L Q +A+ + R + + +Q QE +RL + AR+R Q
Sbjct: 2503 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE----------ARRR-------Q 2545
Query: 353 EAAEERESAREEE--EAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEE 408
AEE ++EE + EQ+RR EE + EE++ E EE RA AL +EE
Sbjct: 2546 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEE 2600
Score = 30.4 bits (67), Expect = 5.0
Identities = 79/386 (20%), Positives = 134/386 (34%), Gaps = 47/386 (12%)
Query: 120 RSQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQE 179
R++ S + + AA R Q E + +E E +L QE + +
Sbjct: 2013 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2072
Query: 180 TAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSG 239
AAE RV E + + +V E L A Q QAR
Sbjct: 2073 RRAAEEAEEA----RVQAEREAAQS---------RRQVEEAERLKQSAEEQAQARAQAQA 2119
Query: 240 PLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARR-PESALLGGSEAGERLL- 297
+ K E ++ + +A + Q A K ++ E L ++ + L
Sbjct: 2120 AAEKLRKEAEQEAARRAQAEQAAL---RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2176
Query: 298 ----------QQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLG 347
Q+ L E R +AEAT +AA Q ++ + + +Q + R
Sbjct: 2177 LRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR--- 2232
Query: 348 GRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNAL--LF 405
EA R+++ ++ + E++ + EEAA A+EA R RQ A L
Sbjct: 2233 ----IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2288
Query: 406 AEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGE---------EEDDEEMDPQTIDSLI 456
+ E ++K + + EAE ++ E +ED E+M Q +
Sbjct: 2289 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2348
Query: 457 ELSTKLHLPADDVVSIIEEVEEKRKR 482
L + + E E + R
Sbjct: 2349 GFQRTLEAERQRQLEMSAEAERLKLR 2374
Score = 29.6 bits (65), Expect = 8.5
Identities = 15/35 (42%), Positives = 22/35 (62%)
Query: 580 EAQARRAQEEAEAEERRLQEQEELENYIEHVLLRR 614
EAQ R+AQEEAE R++Q++ + + E L R
Sbjct: 1472 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1506
>gi|47607492 plectin 1 isoform 1 [Homo sapiens]
Length = 4574
Score = 56.6 bits (135), Expect = 7e-08
Identities = 98/371 (26%), Positives = 152/371 (40%), Gaps = 43/371 (11%)
Query: 149 ASDPSEELEALASLLQELRDFSPSS--AKRQQETAAAETETRTHTLTRV-NLESPGPERV 205
A D ++ ++ LQ+LR S + AK +Q AA + R RV L+ ER
Sbjct: 1435 AVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQ 1494
Query: 206 WRASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPL 265
+ GE QA RA + QA+ E + V +A L
Sbjct: 1495 RGGAEGELQAL---RARAEEAEAQKRQAQ-------EEAERLRRQVQDESQRKRQAEVEL 1544
Query: 266 SKAYQGVAAPFPKARRPESAL----LGGSEAGERLLQQGLAQVEAGRRQAEA--TRQAAA 319
+ + A + +R AL L EA RL Q A+VE R+ A T Q +A
Sbjct: 1545 ASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQ---AEVERARQVQVALETAQRSA 1601
Query: 320 QEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEER-----ESAREEEEAEQERRGG 374
+ E + AS L+ ++ + L+E AE R E+ R EEAE+E
Sbjct: 1602 EAELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAEREL--- 1658
Query: 375 EERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEG 434
ER + EA +AEE A+Q +L AE AE ++ + E RR +AE
Sbjct: 1659 -ERWQLKANEALRLRLQAEEV--AQQKSLAQAE-------AEKQKEEAEREARRRGKAEE 1708
Query: 435 TEEGGEEEDDEEMDPQTIDSLIELSTKLHLPAD-DVVSIIEEVEEKRKRKKNAPPEPVPP 493
E ++E++ Q L E + + L A+ +++ + E E+ ++++ E
Sbjct: 1709 QAVRQRELAEQELEKQR--QLAEGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARL 1766
Query: 494 PRAAPAPTHVR 504
R A A T R
Sbjct: 1767 QREAAAATQKR 1777
Score = 50.1 bits (118), Expect = 6e-06
Identities = 105/397 (26%), Positives = 149/397 (37%), Gaps = 67/397 (16%)
Query: 87 LQALDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPP-----RPQ 141
LQ L + + + ++Q E + + E +R L A E A R +
Sbjct: 1449 LQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQLEATERQRGGAEGELQALRAR 1508
Query: 142 TPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQET-----------AAAETETRTH 190
E + EE E L +Q+ S KRQ E AA E +
Sbjct: 1509 AEEAEAQKRQAQEEAERLRRQVQD-----ESQRKRQAEVELASRVKAEAEAAREKQRALQ 1563
Query: 191 TLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEG 250
L + L++ ER R QA V ERA A Q R ++ + F E
Sbjct: 1564 ALEELRLQAEEAERRLR------QAEV-ERARQVQVALETAQ-RSAEAELQSKRASFAEK 1615
Query: 251 VSSPKTHLGE---ALAPLSKAYQGVAAPFPKARRPES---------------ALLGGSEA 292
+ + L E A+A L + + A +A R AL +A
Sbjct: 1616 TAQLERSLQEEHVAVAQLREEAERRAQQQAEAERAREEAERELERWQLKANEALRLRLQA 1675
Query: 293 GERLLQQGLAQVEAGRRQAEATRQAA--AQEERLADLASDLLLQYLLQGGARQRGLG-GR 349
E Q+ LAQ EA +++ EA R+A + E A +L Q L +QR L G
Sbjct: 1676 EEVAQQKSLAQAEAEKQKEEAEREARRRGKAEEQAVRQRELAEQEL----EKQRQLAEGT 1731
Query: 350 GLQEAAEERESAR---EEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAE------RARQ 400
Q A E+E R E E+ EQ+R+ EE + EAA A + +E E RA
Sbjct: 1732 AQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAAAATQKRQELEAELAKVRAEM 1791
Query: 401 NALLF----AEEEDGEAGAEDKRSQEETPGHRRKEAE 433
LL AEEE + K+ E G R+ AE
Sbjct: 1792 EVLLASKARAEEESRSTSEKSKQRLEAEAGRFRELAE 1828
Score = 49.3 bits (116), Expect = 1e-05
Identities = 56/198 (28%), Positives = 88/198 (44%), Gaps = 34/198 (17%)
Query: 267 KAYQGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLAD 326
+ + +AA AR+ ++AL E ERL A+VE RR E Q +A++ +LA
Sbjct: 2016 RVQKSLAAEEEAARQRKAAL----EEVERLK----AKVEEARRLRERAEQESARQLQLAQ 2067
Query: 327 LASDLLLQY---------------LLQGGARQRGLGGRGLQEAAEERESAREEEEAEQER 371
A+ LQ L Q +++ + + EA R +A E EEA
Sbjct: 2068 EAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV-- 2125
Query: 372 RGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAE-EEDGEAGAEDKRSQEETPGHRRK 430
+ + EAA++ + EEAER +Q+A A+ +A AE R + E RR
Sbjct: 2126 --------QAEREAAQSRRQVEEAERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRA 2177
Query: 431 EAEGTEEGGEEEDDEEMD 448
+AE ++ D EM+
Sbjct: 2178 QAEQAALRQKQAADAEME 2195
Score = 48.9 bits (115), Expect = 1e-05
Identities = 81/345 (23%), Positives = 139/345 (40%), Gaps = 78/345 (22%)
Query: 295 RLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQ-YLLQGGARQRGLGGRGLQE 353
+ + + L ++E R AE +Q A + ERLA++ + L Q L + A+ + R +E
Sbjct: 1362 KFISETLRRMEEEERLAE--QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAKE 1419
Query: 354 AAE--ERESAREEE---EAEQERRGGEERVGE-EDEEAAEAEAEAEEAERARQNALLFAE 407
+ + E R EE +A+Q++R +E + + AE +A+A +AE A ++ L E
Sbjct: 1420 LQQRMQEEVVRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQAEAAERSRLRIEE 1479
Query: 408 E-----------EDGEAGAED-----KRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQT 451
E E GAE + EE +R+ E E + DE +
Sbjct: 1480 EIRVVRLQLEATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQ 1539
Query: 452 IDSLIELSTKLHLPADDV------VSIIEEV----EEKRKRKKNAPPEPVPPPRAAPAPT 501
+ +EL++++ A+ + +EE+ EE +R + A E RA
Sbjct: 1540 AE--VELASRVKAEAEAAREKQRALQALEELRLQAEEAERRLRQAEVE-----RARQVQV 1592
Query: 502 HVRSPQPPPPAPAPARDELPDWNEVLPPWDREEDEVYPPGPYHPFPNYIRPRTLQPPSAL 561
+ + Q A A + + + E +T Q +L
Sbjct: 1593 ALETAQRS--AEAELQSKRASFAE---------------------------KTAQLERSL 1623
Query: 562 RRRHYHHALPPSRHYPGREAQARRAQEEAEAEERRLQEQEELENY 606
+ H A RE RRAQ++AEAE R + + ELE +
Sbjct: 1624 QEEHVAVAQL-------REEAERRAQQQAEAERAREEAERELERW 1661
Score = 47.8 bits (112), Expect = 3e-05
Identities = 86/398 (21%), Positives = 145/398 (36%), Gaps = 26/398 (6%)
Query: 90 LDRPASPPAPSGSQQGPEEEAAEALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEA 149
L+ ASP Q G E E + T S+ +L + + R E
Sbjct: 1320 LEPVASPAKKPKVQSGSESVIQEYVDLRTHYSELTTLTSQYIKFISETLRRMEEEERLAE 1379
Query: 150 SDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWRAS 209
+EE E LA + L + Q A AE E + L+ E V R
Sbjct: 1380 QQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK-------ELQQRMQEEVVRRE 1432
Query: 210 WGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAY 269
A+ +R+ Q R + + E + + E + +
Sbjct: 1433 EAAVDAQQQKRSI----QEELQQLRQSSEAEIQAKARQAEAAERSRLRIEEEIRVVRLQL 1488
Query: 270 QGVAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLAS 329
+ A AL +E E +Q + E RRQ + Q Q E +LAS
Sbjct: 1489 EATERQRGGAEGELQALRARAEEAEAQKRQAQEEAERLRRQVQDESQRKRQAE--VELAS 1546
Query: 330 DLLLQYLLQGGARQRGLGGRGLQEAAEERESA-REEEEAEQERRGGEERVGEEDEEAAEA 388
+ + AR++ + L+E + E A R +AE ER + E + +AEA
Sbjct: 1547 RVKAE---AEAAREKQRALQALEELRLQAEEAERRLRQAEVERARQVQVALETAQRSAEA 1603
Query: 389 EAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMD 448
E +++ A A + A L ++ R + E RR + + E EE + E++
Sbjct: 1604 ELQSKRASFAEKTAQLERSLQEEHVAVAQLREEAE----RRAQQQAEAERAREEAERELE 1659
Query: 449 PQTIDSLIELSTKLHLPADDVV---SIIEEVEEKRKRK 483
+ + + +L L A++V S+ + EK+K +
Sbjct: 1660 RWQLKA--NEALRLRLQAEEVAQQKSLAQAEAEKQKEE 1695
Score = 47.8 bits (112), Expect = 3e-05
Identities = 100/423 (23%), Positives = 158/423 (37%), Gaps = 48/423 (11%)
Query: 53 DGSAPEVRGARNSEPQDEGELFQGVDPRALAAVLLQALDRPASPPAPSGSQQGPEEEAA- 111
+G+A + A + E QG R L L L R A+ A + +Q E E A
Sbjct: 1729 EGTAQQRLAAEQELIRLRAETEQGEQQRQLLEEELARLQREAA--AATQKRQELEAELAK 1786
Query: 112 -----EALLTETVRSQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQEL 166
E LL R++ S E + E ++ + L ALA +
Sbjct: 1787 VRAEMEVLLASKARAEEESRSTSEKSKQRLEAEAGRFR---ELAEEAARLRALAEEAKRQ 1843
Query: 167 RDFSPSSAKRQ---------QETAAAETETRTHTLTRVNLESPGPE--RVWRASWGE-FQ 214
R + A RQ ++ AA TR T + L+ E R+ R + E FQ
Sbjct: 1844 RQLAEEDAARQRAEAERVLAEKLAAIGEATRLKTEAEIALKEKEAENERLRRLAEDEAFQ 1903
Query: 215 ARVPERAPLPPPAPSQ---FQARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQG 271
R E A + Q R L E + + E + L +++
Sbjct: 1904 RRRLEEQAAQHKADIEERLAQLRKASDSELERQKGLVEDTLRQRRQVEEEILALKASFEK 1963
Query: 272 VAAPFPKARRPESALLGGSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDL 331
AA + + +E R +Q A++EA R+ RQ AA+EER A +
Sbjct: 1964 AAAGKAELELELGRIRSNAEDTLRSKEQ--AELEAARQ-----RQLAAEEERRRREAEER 2016
Query: 332 LLQYLL--QGGARQRGLGGRGLQEAAEERESAREEEEAEQERRGGEE--RVGEEDEEAAE 387
+ + L + ARQR L+E ER A+ EE R +E R + +EAA+
Sbjct: 2017 VQKSLAAEEEAARQRKAA---LEEV--ERLKAKVEEARRLRERAEQESARQLQLAQEAAQ 2071
Query: 388 AEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEM 447
+AEE A FA ++ + + + ++ R EAE EE ++ +
Sbjct: 2072 KRLQAEEKAHA------FAVQQKEQELQQTLQQEQSVLDQLRGEAEAARRAAEEAEEARV 2125
Query: 448 DPQ 450
+
Sbjct: 2126 QAE 2128
Score = 46.6 bits (109), Expect = 7e-05
Identities = 63/249 (25%), Positives = 103/249 (41%), Gaps = 36/249 (14%)
Query: 174 AKRQQETAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQA 233
A RQ++ AA E R ERV ++ E +A +A L + +A
Sbjct: 1996 AARQRQLAAEEERRRREA----------EERVQKSLAAEEEAARQRKAALEEV--ERLKA 2043
Query: 234 RMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAG 293
++ ++ L E E S+ + L + A + A F ++ E L +
Sbjct: 2044 KVEEARRLRER---AEQESARQLQLAQEAAQKRLQAEEKAHAFA-VQQKEQELQQTLQQE 2099
Query: 294 ERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQE 353
+ +L Q + EA RR AE +A Q ER A A+ R R ++E
Sbjct: 2100 QSVLDQLRGEAEAARRAAEEAEEARVQAEREA---------------AQSR----RQVEE 2140
Query: 354 AAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEA 413
A ++SA E+ +A + + E++ +E E+ A A+AE+A RQ AE E +
Sbjct: 2141 AERLKQSAEEQAQARAQAQAAAEKLRKEAEQEAARRAQAEQA-ALRQKQAADAEMEKHKK 2199
Query: 414 GAEDKRSQE 422
AE Q+
Sbjct: 2200 FAEQTLRQK 2208
Score = 41.6 bits (96), Expect = 0.002
Identities = 54/168 (32%), Positives = 75/168 (44%), Gaps = 15/168 (8%)
Query: 278 KARRPESALLGGSEAGERLLQQGLAQVEAGRR-QAEATRQAAAQEERLADLASDLLLQYL 336
KA+ E+ L E Q LAQ A +R QAE A A +++ +L L +
Sbjct: 2042 KAKVEEARRLRERAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQS 2101
Query: 337 LQGGARQRGLGGRGLQEAAEERESAR--EEEEAEQERRGGEE-----RVGEEDEEA-AEA 388
+ R R AAEE E AR E EA Q RR EE + EE +A A+A
Sbjct: 2102 VLDQLRGEAEAAR---RAAEEAEEARVQAEREAAQSRRQVEEAERLKQSAEEQAQARAQA 2158
Query: 389 EAEAEEAER-ARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGT 435
+A AE+ + A Q A A+ E +A K++ + +K AE T
Sbjct: 2159 QAAAEKLRKEAEQEAARRAQAE--QAALRQKQAADAEMEKHKKFAEQT 2204
Score = 38.5 bits (88), Expect = 0.018
Identities = 84/370 (22%), Positives = 140/370 (37%), Gaps = 56/370 (15%)
Query: 149 ASDPSEELEA-LASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWR 207
A+ +ELEA LA + E+ S A+ ++E+ + +++
Sbjct: 1773 ATQKRQELEAELAKVRAEMEVLLASKARAEEESRSTSEKSKQRL---------------E 1817
Query: 208 ASWGEFQARVPERAPLPPPAPSQFQARMPDSGPLPETHKFGEGVSSPK-THLGEALAPLS 266
A G F+ E A L A + R E V + K +GEA +
Sbjct: 1818 AEAGRFRELAEEAARLRALAEEAKRQRQLAEEDAARQRAEAERVLAEKLAAIGEATRLKT 1877
Query: 267 KAYQGVAAPFPKARRPESALLGGSEAGERL-LQQGLAQVEAG--RRQAEATRQAAAQEER 323
+A +A +A L EA +R L++ AQ +A R A+ + + ++ ER
Sbjct: 1878 EAE--IALKEKEAENERLRRLAEDEAFQRRRLEEQAAQHKADIEERLAQLRKASDSELER 1935
Query: 324 LADLASDLLLQ-------YLLQGGARQRGLGGRG--------LQEAAEERESAREEEEAE 368
L D L Q L + ++ G+ ++ AE+ ++E+ E E
Sbjct: 1936 QKGLVEDTLRQRRQVEEEILALKASFEKAAAGKAELELELGRIRSNAEDTLRSKEQAELE 1995
Query: 369 QERR----GGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAED-----KR 419
R+ EER E EE + AEE E ARQ E E +A E+ +R
Sbjct: 1996 AARQRQLAAEEERRRREAEERVQKSLAAEE-EAARQRKAALEEVERLKAKVEEARRLRER 2054
Query: 420 SQEET---------PGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVV 470
+++E+ +R +AE + E+ QT+ + +L A+
Sbjct: 2055 AEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAAR 2114
Query: 471 SIIEEVEEKR 480
EE EE R
Sbjct: 2115 RAAEEAEEAR 2124
Score = 38.1 bits (87), Expect = 0.024
Identities = 71/289 (24%), Positives = 115/289 (39%), Gaps = 33/289 (11%)
Query: 148 EASDPSEELEALASLLQELRDFSPSSAKRQQETAAAETETRTHTLTRVNLESPGPERVWR 207
+A + L+A A LLQ+ ++ + A+R QE + E L E+ G +R
Sbjct: 2344 QAVQEATRLKAEAELLQQQKELAQEQARRLQE----DKEQMAQQLAE---ETQGFQRTLE 2396
Query: 208 ASWG---EFQARVPERAPLPPPAPSQFQARMPDSGPL--PETHKFGEGVSSPKTHLGEAL 262
A E A ER L S+ QAR + + + GE + + E +
Sbjct: 2397 AERQRQLEMSAEA-ERLKLRVAEMSRAQARAEEDAQRFRKQAEEIGEKLHRTELATQEKV 2455
Query: 263 APLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQG-LAQVEAGRRQAEATRQAAAQE 321
+ A R A+ E+L Q+ L Q+++ Q Q +
Sbjct: 2456 TLVQTLEIQRQQSDHDAERLREAIAELEREKEKLQQEAKLLQLKSEEMQTVQQEQLLQET 2515
Query: 322 ERLADL---ASDLLLQ---YLLQGGARQRGLGGRGLQEAAEERESA-REEEEAEQERRGG 374
+ L D LLQ ++ Q A+ L + +A + RE R++++ EQER
Sbjct: 2516 QALQQSFLSEKDSLLQRERFIEQEKAKLEQLFQDEVAKAQQLREEQQRQQQQMEQER--- 2572
Query: 375 EERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEE 423
+R+ EEA + EAEE R +Q L E++ +R QEE
Sbjct: 2573 -QRLVASMEEARRRQHEAEEGVRRKQEELQQLEQQ--------RRQQEE 2612
Score = 35.4 bits (80), Expect = 0.16
Identities = 85/376 (22%), Positives = 135/376 (35%), Gaps = 46/376 (12%)
Query: 243 ETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSEAGERLLQQGLA 302
E K + V + L A L K A P L G E GERL Q+
Sbjct: 1137 EQLKEAQAVPATLPELEATKASLKKLRAQAEAQQPTFDALRDELRGAQEVGERLQQR--- 1193
Query: 303 QVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQ-----EAAEE 357
G R E R ER+A L + L Q RQR L G Q E+A+
Sbjct: 1194 ---HGERDVEVER----WRERVAQLL-ERWQAVLAQTDVRQRELEQLGRQLRYYRESADP 1245
Query: 358 -----RESAREEEEAE----QERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEE 408
+++ R +E+ + + + E++ +E E E E+ E ++ A +
Sbjct: 1246 LGAWLQDARRRQEQIQAMPLADSQAVREQLRQEQALLEEIERHGEKVEECQRFAKQYINA 1305
Query: 409 -EDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPAD 467
+D E ++Q E K+ + + G E E +D +T S EL+T
Sbjct: 1306 IKDYELQLVTYKAQLEPVASPAKKPK-VQSGSESVIQEYVDLRTHYS--ELTTL----TS 1358
Query: 468 DVVSIIEEVEEKRKRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVL 527
+ I E + + ++ + R A + A A A+ + E
Sbjct: 1359 QYIKFISETLRRMEEEERLAEQQRAEERERLAEVEAALEKQRQLAEAHAQAKAQAEREAK 1418
Query: 528 PPWDREEDEVYPPGPYHPFPNYIRPRTLQPPSALRRRHYHHALPPSRHYPGREAQARRAQ 587
R ++EV +R + ++R L R E QA+ Q
Sbjct: 1419 ELQQRMQEEV------------VRREEAAVDAQQQKRSIQEELQQLRQSSEAEIQAKARQ 1466
Query: 588 EEAEAEERRLQEQEEL 603
EA AE RL+ +EE+
Sbjct: 1467 AEA-AERSRLRIEEEI 1481
Score = 33.9 bits (76), Expect = 0.45
Identities = 36/118 (30%), Positives = 54/118 (45%), Gaps = 23/118 (19%)
Query: 294 ERLLQQGLAQVEAGRRQAEATRQAAAQE-ERLADLASDLLLQYLLQGGARQRGLGGRGLQ 352
E+L Q +A+ + R + + +Q QE +RL + AR+R Q
Sbjct: 2544 EQLFQDEVAKAQQLREEQQRQQQQMEQERQRLVASMEE----------ARRR-------Q 2586
Query: 353 EAAEERESAREEE--EAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEE 408
AEE ++EE + EQ+RR EE + EE++ E EE RA AL +EE
Sbjct: 2587 HEAEEGVRRKQEELQQLEQQRRQQEELLAEENQRLREQLQLLEEQHRA---ALAHSEE 2641
Score = 30.4 bits (67), Expect = 5.0
Identities = 79/386 (20%), Positives = 134/386 (34%), Gaps = 47/386 (12%)
Query: 120 RSQTHSLPAPESPEPAAPPRPQTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQE 179
R++ S + + AA R Q E + +E E +L QE + +
Sbjct: 2054 RAEQESARQLQLAQEAAQKRLQAEEKAHAFAVQQKEQELQQTLQQEQSVLDQLRGEAEAA 2113
Query: 180 TAAAETETRTHTLTRVNLESPGPERVWRASWGEFQARVPERAPLPPPAPSQFQARMPDSG 239
AAE RV E + + +V E L A Q QAR
Sbjct: 2114 RRAAEEAEEA----RVQAEREAAQS---------RRQVEEAERLKQSAEEQAQARAQAQA 2160
Query: 240 PLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARR-PESALLGGSEAGERLL- 297
+ K E ++ + +A + Q A K ++ E L ++ + L
Sbjct: 2161 AAEKLRKEAEQEAARRAQAEQAAL---RQKQAADAEMEKHKKFAEQTLRQKAQVEQELTT 2217
Query: 298 ----------QQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLG 347
Q+ L E R +AEAT +AA Q ++ + + +Q + R
Sbjct: 2218 LRLQLEETDHQKNLLDEELQRLKAEAT-EAARQRSQVEEELFSVRVQMEELSKLKAR--- 2273
Query: 348 GRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNAL--LF 405
EA R+++ ++ + E++ + EEAA A+EA R RQ A L
Sbjct: 2274 ----IEAENRALILRDKDNTQRFLQEEAEKMKQVAEEAARLSVAAQEAARLRQLAEEDLA 2329
Query: 406 AEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGE---------EEDDEEMDPQTIDSLI 456
+ E ++K + + EAE ++ E +ED E+M Q +
Sbjct: 2330 QQRALAEKMLKEKMQAVQEATRLKAEAELLQQQKELAQEQARRLQEDKEQMAQQLAEETQ 2389
Query: 457 ELSTKLHLPADDVVSIIEEVEEKRKR 482
L + + E E + R
Sbjct: 2390 GFQRTLEAERQRQLEMSAEAERLKLR 2415
Score = 29.6 bits (65), Expect = 8.5
Identities = 15/35 (42%), Positives = 22/35 (62%)
Query: 580 EAQARRAQEEAEAEERRLQEQEELENYIEHVLLRR 614
EAQ R+AQEEAE R++Q++ + + E L R
Sbjct: 1513 EAQKRQAQEEAERLRRQVQDESQRKRQAEVELASR 1547
>gi|4505101 microtubule-associated protein 7 [Homo sapiens]
Length = 749
Score = 56.6 bits (135), Expect = 7e-08
Identities = 101/400 (25%), Positives = 149/400 (37%), Gaps = 72/400 (18%)
Query: 83 AAVLLQALDRP---ASPPAPS-------GSQQGPEEEAAEALLTETVRSQTHSLPAPESP 132
AA ++DRP +PP S G+ +E E +L T S T +P +P
Sbjct: 262 AAHSRNSMDRPKLFVTPPEGSSRRRIIHGTASYKKERERENVLFLT--SGTRRAVSPSNP 319
Query: 133 EPAAPPR-------------PQTPENGPEASDPSEELEALASLLQELRDFSPSSAKRQQE 179
+ P R P TP P +S P ++A + ++R SP + + +
Sbjct: 320 KARQPARSRLWLPSKSLPHLPGTPR--PTSSLPPGSVKAAPA---QVRPPSPGNIRPVKR 374
Query: 180 TAAAETETRT------HTLTRVNLESPGP-ERVWRASWGEFQARVPERAPLPPP-APSQF 231
E E + +L+ P +V A+ E PE P P AP+
Sbjct: 375 EVKVEPEKKDPEKEPQKVANEPSLKGRAPLVKVEEATVEERTPAEPEVGPAAPAMAPAPA 434
Query: 232 QARMPDSGPLPETHKFGEGVSSPKTHLGEALAPLSKAYQGVAAPFPKARRPESALLGGSE 291
A P S P P VS+P + + + + + A G P E
Sbjct: 435 SAPAPASAPAPAPVPTPAMVSAPSSTVNASASVKTSA--GTTDP---------------E 477
Query: 292 AGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQGGARQRGLGGRGL 351
RLL + + R Q E + ++E L + L Q + + +R R L
Sbjct: 478 EATRLLAE---KRRLAREQREKEERERREQEELERQKREELAQRVAEERTTRREEESRRL 534
Query: 352 QEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAE-------AEEAERARQNALL 404
E E ARE+EE Q +R EER E EEA A+ + EEAER RQ
Sbjct: 535 -----EAEQAREKEE--QLQRQAEERALREREEAERAQRQKEEEARVREEAERVRQEREK 587
Query: 405 FAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDD 444
+ E+ E KR +E RR EA + + D
Sbjct: 588 HFQREEQERLERKKRLEEIMKRTRRTEATDKKTSDQRNGD 627
Score = 35.4 bits (80), Expect = 0.16
Identities = 53/205 (25%), Positives = 72/205 (35%), Gaps = 39/205 (19%)
Query: 411 GEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVV 470
G A + + +PG+ R + E++D E+ +PQ + + E S K P V
Sbjct: 352 GSVKAAPAQVRPPSPGNIRPVKREVKVEPEKKDPEK-EPQKVAN--EPSLKGRAPLVKVE 408
Query: 471 -SIIEEVEEKRKRKKNAPPEPVPPPRAAPAPTHVRSPQPPPPAPAPARDELPDWNEVLPP 529
+ +EE A P P P +APAP S P P P PA P
Sbjct: 409 EATVEERTPAEPEVGPAAPAMAPAPASAPAPA---SAPAPAPVPTPAMVSAPSSTVNASA 465
Query: 530 WDREEDEVYPPGPYHPFPNYIRPRTLQPPSALRRRHYHHALPPSRHYPGREAQARRAQEE 589
+ T P A R L R R A+E+
Sbjct: 466 SVKTS-----------------AGTTDPEEATR------LLAEKR---------RLAREQ 493
Query: 590 AEAEERRLQEQEELENYIEHVLLRR 614
E EER +EQEELE L +R
Sbjct: 494 REKEERERREQEELERQKREELAQR 518
Score = 32.3 bits (72), Expect = 1.3
Identities = 23/77 (29%), Positives = 32/77 (41%)
Query: 356 EERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGA 415
+ + ARE E +++ E V E EE A E ER ++ +EE A
Sbjct: 65 DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEERKKRLEEQRQKEERRRAAV 124
Query: 416 EDKRSQEETPGHRRKEA 432
E+KR Q R EA
Sbjct: 125 EEKRRQRLEEDKERHEA 141
Score = 30.8 bits (68), Expect = 3.8
Identities = 27/94 (28%), Positives = 42/94 (44%), Gaps = 6/94 (6%)
Query: 368 EQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGH 427
+++R E R E + AA E ERARQ+ EE + E++R +EE
Sbjct: 65 DRQRLARERREEREKQLAAREIVWLEREERARQHYEKHLEER--KKRLEEQRQKEE---- 118
Query: 428 RRKEAEGTEEGGEEEDDEEMDPQTIDSLIELSTK 461
RR+ A + E+D+E + +E S K
Sbjct: 119 RRRAAVEEKRRQRLEEDKERHEAVVRRTMERSQK 152
Score = 30.4 bits (67), Expect = 5.0
Identities = 39/177 (22%), Positives = 71/177 (40%), Gaps = 31/177 (17%)
Query: 281 RPESALLG--GSEAGERLLQQGLAQVEAGRRQAEATRQAAAQEERLADLASDLLLQYLLQ 338
RP SA+ G + +G + + +V+ +R A R EER LA+ ++ +
Sbjct: 38 RPASAISGQNNNHSGNKPDPPPVLRVDDRQRLARERR-----EEREKQLAAREIVWLERE 92
Query: 339 GGARQRGLGGRGLQEAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERA 398
ARQ ++ EER+ EE+ ++ERR R E++ E + E E
Sbjct: 93 ERARQH------YEKHLEERKKRLEEQRQKEERR----RAAVEEKRRQRLEEDKERHEAV 142
Query: 399 RQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTEEGGEEEDDEEMDPQTIDSL 455
+ + +RSQ+ H R G+ G + D +++ ++
Sbjct: 143 VRRTM--------------ERSQKPKQKHNRWSWGGSLHGSPSIHSADPDRRSVSTM 185
>gi|56549694 enabled homolog isoform a [Homo sapiens]
Length = 591
Score = 55.5 bits (132), Expect = 1e-07
Identities = 82/306 (26%), Positives = 106/306 (34%), Gaps = 50/306 (16%)
Query: 261 ALAPLSKAYQGVAAPFPKARRPESALLGGS----EAGERLLQQGLAQVEAGRRQAEATRQ 316
AL L+ G P ++ P G S E R LQ+ Q E R + E R
Sbjct: 107 ALEVLNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERM 166
Query: 317 AAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEERESAREEEEAEQERRGGEE 376
+ ER L + L + L+ +R R QE E +E +E E++ R E
Sbjct: 167 ERERLER-ERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRE 225
Query: 377 RVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTE 436
R ++ E E E E ER RQ L E E E E + S P + T
Sbjct: 226 RQERQERERLE-RLERERQERERQEQL---EREQLEWERERRISSAAAPA-----SVETP 276
Query: 437 EGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKRKRKKNAPPEPVPPPRA 496
D +P L S P+ + + P P PPP
Sbjct: 277 LNSVLGDSSASEP----GLQAASQPAETPSQQGIVL-------------GPLAPPPPPPL 319
Query: 497 APAPTH--VRSPQPP-PPAPAPARDELPDWNEVLPPWDREEDEVYPPGPYHPFPNYIRPR 553
P P V P PP PP P P LP PP PP P P PN + P
Sbjct: 320 PPGPAQASVALPPPPGPPPPPP----LPSTG---PP---------PPPPPPPLPNQVPPP 363
Query: 554 TLQPPS 559
PP+
Sbjct: 364 PPPPPA 369
Score = 31.6 bits (70), Expect = 2.2
Identities = 32/156 (20%), Positives = 49/156 (31%), Gaps = 9/156 (5%)
Query: 35 LSSEHKEPVAGDAVPGPKDGSAPEVRGARNSEPQDEGELFQGVDPRALAAVLLQALDRPA 94
L E + ++ A P + V G ++ Q + + ++L L P
Sbjct: 256 LEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPP 315
Query: 95 SPPAPSGSQQ---------GPEEEAAEALLTETVRSQTHSLPAPESPEPAAPPRPQTPEN 145
PP P G Q GP LP P P PP P P +
Sbjct: 316 PPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPAS 375
Query: 146 GPEASDPSEELEALASLLQELRDFSPSSAKRQQETA 181
G + SE+ L L + R ++T+
Sbjct: 376 GFFLASMSEDNRPLTGLAAAIAGAKLRKVSRMEDTS 411
>gi|39930375 enabled homolog isoform b [Homo sapiens]
Length = 570
Score = 55.5 bits (132), Expect = 1e-07
Identities = 82/306 (26%), Positives = 106/306 (34%), Gaps = 50/306 (16%)
Query: 261 ALAPLSKAYQGVAAPFPKARRPESALLGGS----EAGERLLQQGLAQVEAGRRQAEATRQ 316
AL L+ G P ++ P G S E R LQ+ Q E R + E R
Sbjct: 107 ALEVLNSQETGPTLPRQNSQLPAQVQNGPSQEELEIQRRQLQEQQRQKELERERLERERM 166
Query: 317 AAAQEERLADLASDLLLQYLLQGGARQRGLGGRGLQEAAEERESAREEEEAEQERRGGEE 376
+ ER L + L + L+ +R R QE E +E +E E++ R E
Sbjct: 167 ERERLER-ERLERERLERERLEQEQLERERQERERQERLERQERLERQERLERQERLDRE 225
Query: 377 RVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQEETPGHRRKEAEGTE 436
R ++ E E E E ER RQ L E E E E + S P + T
Sbjct: 226 RQERQERERLE-RLERERQERERQEQL---EREQLEWERERRISSAAAPA-----SVETP 276
Query: 437 EGGEEEDDEEMDPQTIDSLIELSTKLHLPADDVVSIIEEVEEKRKRKKNAPPEPVPPPRA 496
D +P L S P+ + + P P PPP
Sbjct: 277 LNSVLGDSSASEP----GLQAASQPAETPSQQGIVL-------------GPLAPPPPPPL 319
Query: 497 APAPTH--VRSPQPP-PPAPAPARDELPDWNEVLPPWDREEDEVYPPGPYHPFPNYIRPR 553
P P V P PP PP P P LP PP PP P P PN + P
Sbjct: 320 PPGPAQASVALPPPPGPPPPPP----LPSTG---PP---------PPPPPPPLPNQVPPP 363
Query: 554 TLQPPS 559
PP+
Sbjct: 364 PPPPPA 369
Score = 31.6 bits (70), Expect = 2.2
Identities = 32/156 (20%), Positives = 49/156 (31%), Gaps = 9/156 (5%)
Query: 35 LSSEHKEPVAGDAVPGPKDGSAPEVRGARNSEPQDEGELFQGVDPRALAAVLLQALDRPA 94
L E + ++ A P + V G ++ Q + + ++L L P
Sbjct: 256 LEWERERRISSAAAPASVETPLNSVLGDSSASEPGLQAASQPAETPSQQGIVLGPLAPPP 315
Query: 95 SPPAPSGSQQ---------GPEEEAAEALLTETVRSQTHSLPAPESPEPAAPPRPQTPEN 145
PP P G Q GP LP P P PP P P +
Sbjct: 316 PPPLPPGPAQASVALPPPPGPPPPPPLPSTGPPPPPPPPPLPNQVPPPPPPPPAPPLPAS 375
Query: 146 GPEASDPSEELEALASLLQELRDFSPSSAKRQQETA 181
G + SE+ L L + R ++T+
Sbjct: 376 GFFLASMSEDNRPLTGLAAAIAGAKLRKVSRMEDTS 411
>gi|105990539 neurofilament, light polypeptide 68kDa [Homo sapiens]
Length = 543
Score = 55.5 bits (132), Expect = 1e-07
Identities = 30/91 (32%), Positives = 49/91 (53%)
Query: 353 EAAEERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGE 412
E E E+A+ EE ++ GE E+D+E AE E AEE E A++ + EEE+G
Sbjct: 453 EVEETIEAAKAEEAKDEPPSEGEAEEEEKDKEEAEEEEAAEEEEAAKEESEEAKEEEEGG 512
Query: 413 AGAEDKRSQEETPGHRRKEAEGTEEGGEEED 443
G E + ++E ++ E G E+ +++D
Sbjct: 513 EGEEGEETKEAEEEEKKVEGAGEEQAAKKKD 543
Score = 47.0 bits (110), Expect = 5e-05
Identities = 25/45 (55%), Positives = 32/45 (71%), Gaps = 1/45 (2%)
Query: 352 QEAAEERESAREE-EEAEQERRGGEERVGEEDEEAAEAEAEAEEA 395
+EAAEE E+A+EE EEA++E GGE GEE +EA E E + E A
Sbjct: 489 EEAAEEEEAAKEESEEAKEEEEGGEGEEGEETKEAEEEEKKVEGA 533
Score = 42.7 bits (99), Expect = 0.001
Identities = 30/84 (35%), Positives = 47/84 (55%), Gaps = 12/84 (14%)
Query: 363 EEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGAEDKRSQE 422
+EE+ E E E EE ++ +E EAEE E+ ++ A E+ EA E++ ++E
Sbjct: 448 QEEQIEVEETI-EAAKAEEAKDEPPSEGEAEEEEKDKEEA------EEEEAAEEEEAAKE 500
Query: 423 ETPGHRRKEAEGTEEGGEEEDDEE 446
E+ +EA+ EEGGE E+ EE
Sbjct: 501 ES-----EEAKEEEEGGEGEEGEE 519
Score = 39.7 bits (91), Expect = 0.008
Identities = 31/91 (34%), Positives = 41/91 (45%), Gaps = 8/91 (8%)
Query: 356 EERESAREEEEAEQERRGGEERVGEEDEEAAEAEAEAEEAERARQNALLFAEEEDGEAGA 415
EE+ E EA + +E E EA E E + EEAE A EE+ A
Sbjct: 449 EEQIEVEETIEAAKAEEAKDEPPSEG--EAEEEEKDKEEAEEEE------AAEEEEAAKE 500
Query: 416 EDKRSQEETPGHRRKEAEGTEEGGEEEDDEE 446
E + ++EE G +E E T+E EEE E
Sbjct: 501 ESEEAKEEEEGGEGEEGEETKEAEEEEKKVE 531
Score = 37.7 bits (86), Expect = 0.031
Identities = 24/73 (32%), Positives = 40/73 (54%), Gaps = 8/73 (10%)
Query: 352 QEAAEERESAREEEEAEQERRGGEE-RVGEEDEEAAEAEAEAEEAERARQNALLFAEEED 410
+E +++E A EEE AE+E EE +E+EE E E E EE + A + EE+
Sbjct: 477 EEEEKDKEEAEEEEAAEEEEAAKEESEEAKEEEEGGEGE-EGEETKEAEE------EEKK 529
Query: 411 GEAGAEDKRSQEE 423
E E++ ++++
Sbjct: 530 VEGAGEEQAAKKK 542
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.307 0.128 0.367
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 33,354,235
Number of Sequences: 37866
Number of extensions: 2360343
Number of successful extensions: 54191
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 850
Number of HSP's successfully gapped in prelim test: 1911
Number of HSP's that attempted gapping in prelim test: 19818
Number of HSP's gapped (non-prelim): 20869
length of query: 615
length of database: 18,247,518
effective HSP length: 108
effective length of query: 507
effective length of database: 14,157,990
effective search space: 7178100930
effective search space used: 7178100930
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.6 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.