Search of human proteins with 170932492

Search of human proteins with 170932492

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
         (457 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|170932492 transmembrane protease, serine 5 [Homo sapiens]          961   0.0  
gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo sap...   270   3e-72
gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo sa...   249   5e-66
gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo sa...   249   5e-66
gi|116256363 transmembrane protease, serine 13 [Homo sapiens]         243   2e-64
gi|33695155 hepsin [Homo sapiens]                                     223   2e-58
gi|4504481 hepsin [Homo sapiens]                                      223   2e-58
gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo sa...   220   2e-57
gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo sap...   220   2e-57
gi|23957702 transmembrane protease, serine 6 [Homo sapiens]           216   3e-56
gi|33667063 transmembrane protease, serine 9 [Homo sapiens]           213   3e-55
gi|223942069 enterokinase precursor [Homo sapiens]                    205   6e-53
gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]             202   5e-52
gi|222831592 transmembrane protease, serine 7 [Homo sapiens]          197   2e-50
gi|4503627 coagulation factor XI precursor [Homo sapiens]             197   2e-50
gi|4758508 transmembrane protease, serine 11D [Homo sapiens]          194   1e-49
gi|4506153 prostasin preproprotein [Homo sapiens]                     194   1e-49
gi|117956391 protease, serine, 33 [Homo sapiens]                      193   3e-49
gi|11415040 matriptase [Homo sapiens]                                 191   2e-48
gi|187761337 transmembrane protease, serine 11B [Homo sapiens]        191   2e-48
gi|40254871 transmembrane protease, serine 11E [Homo sapiens]         191   2e-48
gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]       191   2e-48
gi|13994276 marapsin [Homo sapiens]                                   188   1e-47
gi|58218970 protease, serine, 36 [Homo sapiens]                       187   2e-47
gi|29244926 corin [Homo sapiens]                                      186   4e-47
gi|11545839 protease, serine, 22 [Homo sapiens]                       184   1e-46
gi|194018492 transmembrane protease, serine 11F [Homo sapiens]        181   1e-45
gi|68508970 tryptase beta 2 precursor [Homo sapiens]                  180   2e-45
gi|4504383 HGF activator preproprotein [Homo sapiens]                 180   2e-45
gi|4505881 plasminogen [Homo sapiens]                                 180   3e-45

>gi|170932492 transmembrane protease, serine 5 [Homo sapiens]
          Length = 457

 Score =  961 bits (2483), Expect = 0.0
 Identities = 457/457 (100%), Positives = 457/457 (100%)

Query: 1   MSLMLDDQPPMEAQYAEEGPGPGIFRAEPGDQQHPISQAVCWRSMRRGCAVLGALGLLAG 60
           MSLMLDDQPPMEAQYAEEGPGPGIFRAEPGDQQHPISQAVCWRSMRRGCAVLGALGLLAG
Sbjct: 1   MSLMLDDQPPMEAQYAEEGPGPGIFRAEPGDQQHPISQAVCWRSMRRGCAVLGALGLLAG 60

Query: 61  AGVGSWLLVLYLCPAASQPISGTLQDEEITLSCSEASAEEALLPALPKTVSFRINSEDFL 120
           AGVGSWLLVLYLCPAASQPISGTLQDEEITLSCSEASAEEALLPALPKTVSFRINSEDFL
Sbjct: 61  AGVGSWLLVLYLCPAASQPISGTLQDEEITLSCSEASAEEALLPALPKTVSFRINSEDFL 120

Query: 121 LEAQVRDQPRWLLVCHEGWSPALGLQICWSLGHLRLTHHKGVNLTDIKLNSSQEFAQLSP 180
           LEAQVRDQPRWLLVCHEGWSPALGLQICWSLGHLRLTHHKGVNLTDIKLNSSQEFAQLSP
Sbjct: 121 LEAQVRDQPRWLLVCHEGWSPALGLQICWSLGHLRLTHHKGVNLTDIKLNSSQEFAQLSP 180

Query: 181 RLGGFLEEAWQPRNNCTSGQVVSLRCSECGARPLASRIVGGQSVAPGRWPWQASVALGFR 240
           RLGGFLEEAWQPRNNCTSGQVVSLRCSECGARPLASRIVGGQSVAPGRWPWQASVALGFR
Sbjct: 181 RLGGFLEEAWQPRNNCTSGQVVSLRCSECGARPLASRIVGGQSVAPGRWPWQASVALGFR 240

Query: 241 HTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVSHSAVRPHQGALVERIIPHPLY 300
           HTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVSHSAVRPHQGALVERIIPHPLY
Sbjct: 241 HTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVSHSAVRPHQGALVERIIPHPLY 300

Query: 301 SAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDM 360
           SAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDM
Sbjct: 301 SAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDM 360

Query: 361 LQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLV 420
           LQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLV
Sbjct: 361 LQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLV 420

Query: 421 GVVSWGRGCAEPNHPGVYAKVAEFLDWIHDTAQDSLL 457
           GVVSWGRGCAEPNHPGVYAKVAEFLDWIHDTAQDSLL
Sbjct: 421 GVVSWGRGCAEPNHPGVYAKVAEFLDWIHDTAQDSLL 457


>gi|13173471 transmembrane protease, serine 3 isoform 1 [Homo
           sapiens]
          Length = 454

 Score =  270 bits (689), Expect = 3e-72
 Identities = 140/349 (40%), Positives = 191/349 (54%), Gaps = 10/349 (2%)

Query: 113 RINSEDFLLEAQVRDQPRWLLVCHEGWSPALGLQICWSLGHLRLTHHKGVNLTDIKLNSS 172
           R+  ++ +L  QV     W  +C + W        C  LG         + ++ ++    
Sbjct: 109 RVGGQNAVL--QVFTAASWKTMCSDDWKGHYANVACAQLGFPSYVSSDNLRVSSLEGQFR 166

Query: 173 QEFAQLSPRLGG----FLEEAWQPRNNCTSGQVVSLRCSECG-ARPLASRIVGGQSVAPG 227
           +EF  +   L       L  +   R  C SG VV+L+C+ CG  R  +SRIVGG      
Sbjct: 167 EEFVSIDHLLPDDKVTALHHSVYVREGCASGHVVTLQCTACGHRRGYSSRIVGGNMSLLS 226

Query: 228 RWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVSHSAVRPHQ 287
           +WPWQAS+     H CGGSV+ P W++TAAHC++   L +  SW +  GLVS     P  
Sbjct: 227 QWPWQASLQFQGYHLCGGSVITPLWIITAAHCVYDLYLPK--SWTIQVGLVS-LLDNPAP 283

Query: 288 GALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGW 347
             LVE+I+ H  Y  +    D+AL++L   L F++ +  VCLP  E++FP G  CW SGW
Sbjct: 284 SHLVEKIVYHSKYKPKRLGNDIALMKLAGPLTFNEMIQPVCLPNSEENFPDGKVCWTSGW 343

Query: 348 GHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGG 407
           G T      +S +L    VPL S ++CN   VY G ++P MLCAGYL G  D+CQGDSGG
Sbjct: 344 GATEDGAGDASPVLNHAAVPLISNKICNHRDVYGGIISPSMLCAGYLTGGVDSCQGDSGG 403

Query: 408 PLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWIHDTAQDSL 456
           PLVC +   W+LVG  S+G GCAE N PGVY +V  FLDWIH+  +  L
Sbjct: 404 PLVCQERRLWKLVGATSFGIGCAEVNKPGVYTRVTSFLDWIHEQMERDL 452


>gi|227499990 transmembrane protease, serine 2 isoform 1 [Homo
           sapiens]
          Length = 529

 Score =  249 bits (635), Expect = 5e-66
 Identities = 132/341 (38%), Positives = 181/341 (53%), Gaps = 9/341 (2%)

Query: 113 RINSEDFLLEAQVRDQPRWLLVCHEGWSPALGLQICWSLGHLRLTHHKGVNLTDIKLNSS 172
           R+   +F+L+     +  W  VC + W+   G   C  +G+    +     + D   + S
Sbjct: 187 RLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDD---SGS 243

Query: 173 QEFAQLSPRLGGF-LEEAWQPRNNCTSGQVVSLRCSECGAR---PLASRIVGGQSVAPGR 228
             F +L+   G   + +     + C+S  VVSLRC  CG        SRIVGG+S  PG 
Sbjct: 244 TSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGA 303

Query: 229 WPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVSHSAVRPHQG 288
           WPWQ S+ +   H CGGS++ P W+VTAAHC+    L     W   AG++  S +    G
Sbjct: 304 WPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK-PLNNPWHWTAFAGILRQSFMFYGAG 362

Query: 289 ALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWG 348
             VE++I HP Y ++  + D+AL++LQ  L F+D V  VCLP           CW+SGWG
Sbjct: 363 YQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWG 422

Query: 349 HTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGP 408
            T      +S++L    V L  TQ CNS  VY   +TP M+CAG+L G  D+CQGDSGGP
Sbjct: 423 ATEEKGK-TSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGP 481

Query: 409 LVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWIH 449
           LV    + W L+G  SWG GCA+   PGVY  V  F DWI+
Sbjct: 482 LVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIY 522


>gi|205360943 transmembrane protease, serine 2 isoform 2 [Homo
           sapiens]
          Length = 492

 Score =  249 bits (635), Expect = 5e-66
 Identities = 132/341 (38%), Positives = 181/341 (53%), Gaps = 9/341 (2%)

Query: 113 RINSEDFLLEAQVRDQPRWLLVCHEGWSPALGLQICWSLGHLRLTHHKGVNLTDIKLNSS 172
           R+   +F+L+     +  W  VC + W+   G   C  +G+    +     + D   + S
Sbjct: 150 RLYGPNFILQVYSSQRKSWHPVCQDDWNENYGRAACRDMGYKNNFYSSQGIVDD---SGS 206

Query: 173 QEFAQLSPRLGGF-LEEAWQPRNNCTSGQVVSLRCSECGAR---PLASRIVGGQSVAPGR 228
             F +L+   G   + +     + C+S  VVSLRC  CG        SRIVGG+S  PG 
Sbjct: 207 TSFMKLNTSAGNVDIYKKLYHSDACSSKAVVSLRCIACGVNLNSSRQSRIVGGESALPGA 266

Query: 229 WPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVSHSAVRPHQG 288
           WPWQ S+ +   H CGGS++ P W+VTAAHC+    L     W   AG++  S +    G
Sbjct: 267 WPWQVSLHVQNVHVCGGSIITPEWIVTAAHCVEK-PLNNPWHWTAFAGILRQSFMFYGAG 325

Query: 289 ALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWG 348
             VE++I HP Y ++  + D+AL++LQ  L F+D V  VCLP           CW+SGWG
Sbjct: 326 YQVEKVISHPNYDSKTKNNDIALMKLQKPLTFNDLVKPVCLPNPGMMLQPEQLCWISGWG 385

Query: 349 HTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGP 408
            T      +S++L    V L  TQ CNS  VY   +TP M+CAG+L G  D+CQGDSGGP
Sbjct: 386 ATEEKGK-TSEVLNAAKVLLIETQRCNSRYVYDNLITPAMICAGFLQGNVDSCQGDSGGP 444

Query: 409 LVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWIH 449
           LV    + W L+G  SWG GCA+   PGVY  V  F DWI+
Sbjct: 445 LVTSKNNIWWLIGDTSWGSGCAKAYRPGVYGNVMVFTDWIY 485


>gi|116256363 transmembrane protease, serine 13 [Homo sapiens]
          Length = 567

 Score =  243 bits (621), Expect = 2e-64
 Identities = 129/344 (37%), Positives = 181/344 (52%), Gaps = 9/344 (2%)

Query: 113 RINSEDFLLEAQVRDQPRWLLVCHEGWSPALGLQICWSLGHLRLTHHKGVNLTDIKLNSS 172
           R + +  LL+       +WL +C   W+ +   + C  LG         V   D     +
Sbjct: 228 RFDWDKSLLKIYSGSSHQWLPICSSNWNDSYSEKTCQQLGFESAHRTTEVAHRDF----A 283

Query: 173 QEFAQLSPRLGGFLEEAWQPRNNCTSGQVVSLRCSECGARPLASRIVGGQSVAPGRWPWQ 232
             F+ L  R    ++E+   R+ C S + +SL+CS CG R +  RIVGG   +  +WPWQ
Sbjct: 284 NSFSIL--RYNSTIQESLH-RSECPSQRYISLQCSHCGLRAMTGRIVGGALASDSKWPWQ 340

Query: 233 ASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVSHSAVRPHQGALVE 292
            S+  G  H CGG+++  +WV+TAAHC    R   L  W+V+AG  S+    P   ++ E
Sbjct: 341 VSLHFGTTHICGGTLIDAQWVLTAAHCFFVTREKVLEGWKVYAG-TSNLHQLPEAASIAE 399

Query: 293 RIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHP 352
            II +  Y+ +  DYD+AL+RL   L  S  +   CLP   Q F     CW++G+G T  
Sbjct: 400 III-NSNYTDEEDDYDIALMRLSKPLTLSAHIHPACLPMHGQTFSLNETCWITGFGKTRE 458

Query: 353 SHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGPLVCP 412
           +   +S  L++  V L   + CN   VY   LTPRM+CAG L G  D+CQGDSGGPLVC 
Sbjct: 459 TDDKTSPFLREVQVNLIDFKKCNDYLVYDSYLTPRMMCAGDLRGGRDSCQGDSGGPLVCE 518

Query: 413 DGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWIHDTAQDSL 456
             + W L GV SWG GC + N PGVY KV E L WI+   +  +
Sbjct: 519 QNNRWYLAGVTSWGTGCGQRNKPGVYTKVTEVLPWIYSKMESEV 562


>gi|33695155 hepsin [Homo sapiens]
          Length = 417

 Score =  223 bits (569), Expect = 2e-58
 Identities = 141/412 (34%), Positives = 201/412 (48%), Gaps = 51/412 (12%)

Query: 53  GALGLLAGAGVGSWLLVLYLCPAASQPISGTLQDEEITLSCSEASAEEALLPALPKTVSF 112
           G L LL   G  SW +V  L  +  +P+              + S+ +A L    KT   
Sbjct: 24  GTLLLLTAIGAASWAIVAVLLRSDQEPLYPV-----------QVSSADARLMVFDKT--- 69

Query: 113 RINSEDFLLEAQVRDQPRWLLVCHEGWSPALGLQICWSLGHLRLTHHKGVNLTDIKLNSS 172
                          +  W L+C    +  +    C  +G LR   H  +++     N +
Sbjct: 70  ---------------EGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGT 114

Query: 173 QEFAQLS----PRLGGFLEEAWQPRNNCTSGQVVSLRCSECGARPL-ASRIVGGQSVAPG 227
             F  +     P     LE       +C  G+ ++  C +CG R L   RIVGG+  + G
Sbjct: 115 SGFFCVDEGRLPHTQRLLEVI--SVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLG 172

Query: 228 RWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVSHSAVRPHQ 287
           RWPWQ S+     H CGGS+L+  WV+TAAHC    R   LS WRV AG V+ ++  PH 
Sbjct: 173 RWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPE-RNRVLSRWRVFAGAVAQAS--PHG 229

Query: 288 GAL-VERIIPHPLY------SAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGS 340
             L V+ ++ H  Y      +++ +  D+AL+ L + L  ++ +  VCLPA  Q    G 
Sbjct: 230 LQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGK 289

Query: 341 RCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADA 400
            C V+GWG+T   +   + +LQ+  VP+ S  +CN +  Y   + P+M CAGY +G  DA
Sbjct: 290 ICTVTGWGNTQ-YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDA 348

Query: 401 CQGDSGGPLVCPDG----DTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWI 448
           CQGDSGGP VC D       WRL G+VSWG GCA    PGVY KV++F +WI
Sbjct: 349 CQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWI 400


>gi|4504481 hepsin [Homo sapiens]
          Length = 417

 Score =  223 bits (569), Expect = 2e-58
 Identities = 141/412 (34%), Positives = 201/412 (48%), Gaps = 51/412 (12%)

Query: 53  GALGLLAGAGVGSWLLVLYLCPAASQPISGTLQDEEITLSCSEASAEEALLPALPKTVSF 112
           G L LL   G  SW +V  L  +  +P+              + S+ +A L    KT   
Sbjct: 24  GTLLLLTAIGAASWAIVAVLLRSDQEPLYPV-----------QVSSADARLMVFDKT--- 69

Query: 113 RINSEDFLLEAQVRDQPRWLLVCHEGWSPALGLQICWSLGHLRLTHHKGVNLTDIKLNSS 172
                          +  W L+C    +  +    C  +G LR   H  +++     N +
Sbjct: 70  ---------------EGTWRLLCSSRSNARVAGLSCEEMGFLRALTHSELDVRTAGANGT 114

Query: 173 QEFAQLS----PRLGGFLEEAWQPRNNCTSGQVVSLRCSECGARPL-ASRIVGGQSVAPG 227
             F  +     P     LE       +C  G+ ++  C +CG R L   RIVGG+  + G
Sbjct: 115 SGFFCVDEGRLPHTQRLLEVI--SVCDCPRGRFLAAICQDCGRRKLPVDRIVGGRDTSLG 172

Query: 228 RWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVSHSAVRPHQ 287
           RWPWQ S+     H CGGS+L+  WV+TAAHC    R   LS WRV AG V+ ++  PH 
Sbjct: 173 RWPWQVSLRYDGAHLCGGSLLSGDWVLTAAHCFPE-RNRVLSRWRVFAGAVAQAS--PHG 229

Query: 288 GAL-VERIIPHPLY------SAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGS 340
             L V+ ++ H  Y      +++ +  D+AL+ L + L  ++ +  VCLPA  Q    G 
Sbjct: 230 LQLGVQAVVYHGGYLPFRDPNSEENSNDIALVHLSSPLPLTEYIQPVCLPAAGQALVDGK 289

Query: 341 RCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADA 400
            C V+GWG+T   +   + +LQ+  VP+ S  +CN +  Y   + P+M CAGY +G  DA
Sbjct: 290 ICTVTGWGNTQ-YYGQQAGVLQEARVPIISNDVCNGADFYGNQIKPKMFCAGYPEGGIDA 348

Query: 401 CQGDSGGPLVCPDG----DTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWI 448
           CQGDSGGP VC D       WRL G+VSWG GCA    PGVY KV++F +WI
Sbjct: 349 CQGDSGGPFVCEDSISRTPRWRLCGIVSWGTGCALAQKPGVYTKVSDFREWI 400


>gi|145701030 transmembrane protease, serine 4 isoform 3 [Homo
           sapiens]
          Length = 432

 Score =  220 bits (560), Expect = 2e-57
 Identities = 122/365 (33%), Positives = 183/365 (50%), Gaps = 24/365 (6%)

Query: 91  LSCSEASAEEALLPALPK--TVSFRINSEDFLLEAQVRDQPRWLLVCHEGWSPALGLQIC 148
           L C     EE  + + P+   V+ R++ +   L+        W   C + ++ AL    C
Sbjct: 81  LDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETAC 140

Query: 149 WSLGHLRLTH---HKGVNLTDIKLNSSQEFAQLSPRLGGFLEEAWQPRNNCTSGQVVSLR 205
             +G+ R       + +++ +I  NS +   + S                C SG +VSL 
Sbjct: 141 RQMGYSRAVEIGPDQDLDVVEITENSQELRMRNSS-------------GPCLSGSLVSLH 187

Query: 206 CSECGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRL 265
           C  CG      R+VGG+  +   WPWQ S+    +H CGGS+L P WV+TAAHC      
Sbjct: 188 CLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKH-- 245

Query: 266 ARLSSWRVHAGLVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVG 325
             + +W+V AG     +      A +  I  +P+Y   N   D+AL++LQ  L FS TV 
Sbjct: 246 TDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDN---DIALMKLQFPLTFSGTVR 302

Query: 326 AVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALT 385
            +CLP  ++     +  W+ GWG T  +    SD+L    V +  +  CN+   Y G +T
Sbjct: 303 PICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVT 362

Query: 386 PRMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFL 445
            +M+CAG  +G  D CQGDSGGPL+    D W +VG+VSWG GC  P+ PGVY KV+ +L
Sbjct: 363 EKMMCAGIPEGGVDTCQGDSGGPLMY-QSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYL 421

Query: 446 DWIHD 450
           +WI++
Sbjct: 422 NWIYN 426


>gi|15451940 transmembrane protease, serine 4 isoform 1 [Homo
           sapiens]
          Length = 437

 Score =  220 bits (560), Expect = 2e-57
 Identities = 123/365 (33%), Positives = 183/365 (50%), Gaps = 19/365 (5%)

Query: 91  LSCSEASAEEALLPALPK--TVSFRINSEDFLLEAQVRDQPRWLLVCHEGWSPALGLQIC 148
           L C     EE  + + P+   V+ R++ +   L+        W   C + ++ AL    C
Sbjct: 81  LDCPLGEDEEHCVKSFPEGPAVAVRLSKDRSTLQVLDSATGNWFSACFDNFTEALAETAC 140

Query: 149 WSLGHLRLTHHKGVNLTDIKLNSSQEFAQLSPRLGGFLEEAWQPRNN---CTSGQVVSLR 205
             +G+      + V +   +     E  + S  L        + RN+   C SG +VSL 
Sbjct: 141 RQMGYSSKPTFRAVEIGPDQDLDVVEITENSQEL--------RMRNSSGPCLSGSLVSLH 192

Query: 206 CSECGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRL 265
           C  CG      R+VGG+  +   WPWQ S+    +H CGGS+L P WV+TAAHC      
Sbjct: 193 CLACGKSLKTPRVVGGEEASVDSWPWQVSIQYDKQHVCGGSILDPHWVLTAAHCFRKH-- 250

Query: 266 ARLSSWRVHAGLVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVG 325
             + +W+V AG     +      A +  I  +P+Y   N   D+AL++LQ  L FS TV 
Sbjct: 251 TDVFNWKVRAGSDKLGSFPSLAVAKIIIIEFNPMYPKDN---DIALMKLQFPLTFSGTVR 307

Query: 326 AVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALT 385
            +CLP  ++     +  W+ GWG T  +    SD+L    V +  +  CN+   Y G +T
Sbjct: 308 PICLPFFDEELTPATPLWIIGWGFTKQNGGKMSDILLQASVQVIDSTRCNADDAYQGEVT 367

Query: 386 PRMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFL 445
            +M+CAG  +G  D CQGDSGGPL+    D W +VG+VSWG GC  P+ PGVY KV+ +L
Sbjct: 368 EKMMCAGIPEGGVDTCQGDSGGPLMY-QSDQWHVVGIVSWGYGCGGPSTPGVYTKVSAYL 426

Query: 446 DWIHD 450
           +WI++
Sbjct: 427 NWIYN 431


>gi|23957702 transmembrane protease, serine 6 [Homo sapiens]
          Length = 811

 Score =  216 bits (550), Expect = 3e-56
 Identities = 110/243 (45%), Positives = 143/243 (58%), Gaps = 5/243 (2%)

Query: 208 ECGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLAR 267
           +CG +  +SRIVGG   + G WPWQAS+ +  RH CGG+++A RWV+TAAHC     +A 
Sbjct: 567 DCGLQGPSSRIVGGAVSSEGEWPWQASLQVRGRHICGGALIADRWVITAAHCFQEDSMAS 626

Query: 268 LSSWRVHAGLVSHSAVRPHQGAL-VERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGA 326
              W V  G V  ++  P + +  V R++ HP +   +HDYDVALL+L   +  S  V  
Sbjct: 627 TVLWTVFLGKVWQNSRWPGEVSFKVSRLLLHPYHEEDSHDYDVALLQLDHPVVRSAAVRP 686

Query: 327 VCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTP 386
           VCLPA+   F  G  CW++GWG         S+ LQ   V L    LC+   VY   +TP
Sbjct: 687 VCLPARSHFFEPGLHCWITGWGALREGGPI-SNALQKVDVQLIPQDLCSE--VYRYQVTP 743

Query: 387 RMLCAGYLDGRADACQGDSGGPLVCPD-GDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFL 445
           RMLCAGY  G+ DACQGDSGGPLVC      W L G+VSWG GC  PN+ GVY ++   +
Sbjct: 744 RMLCAGYRKGKKDACQGDSGGPLVCKALSGRWFLAGLVSWGLGCGRPNYFGVYTRITGVI 803

Query: 446 DWI 448
            WI
Sbjct: 804 SWI 806


>gi|33667063 transmembrane protease, serine 9 [Homo sapiens]
          Length = 1059

 Score =  213 bits (542), Expect = 3e-55
 Identities = 109/246 (44%), Positives = 144/246 (58%), Gaps = 9/246 (3%)

Query: 208 ECGARP---LASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFR 264
           ECG +P   +A RIVGG   +PG +PWQAS+     H CG +++  RW+V+AAHC + F+
Sbjct: 190 ECGLQPAWRMAGRIVGGMEASPGEFPWQASLRENKEHFCGAAIINARWLVSAAHCFNEFQ 249

Query: 265 LARLSSWRVHAGLVSHSAVRPHQ-GALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDT 323
               + W  + G    S        A V +I+ HPLY+A   D+DVA+L L + L F   
Sbjct: 250 DP--TKWVAYVGATYLSGSEASTVRAQVVQIVKHPLYNADTADFDVAVLELTSPLPFGRH 307

Query: 324 VGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGA 383
           +  VCLPA    FP   +C +SGWG+         ++LQ   V L    LC S  +Y  +
Sbjct: 308 IQPVCLPAATHIFPPSKKCLISGWGYLKEDFLVKPEVLQKATVELLDQALCAS--LYGHS 365

Query: 384 LTPRMLCAGYLDGRADACQGDSGGPLVCPD-GDTWRLVGVVSWGRGCAEPNHPGVYAKVA 442
           LT RM+CAGYLDG+ D+CQGDSGGPLVC +    + L G+VSWG GCAE   PGVYA+V 
Sbjct: 366 LTDRMVCAGYLDGKVDSCQGDSGGPLVCEEPSGRFFLAGIVSWGIGCAEARRPGVYARVT 425

Query: 443 EFLDWI 448
              DWI
Sbjct: 426 RLRDWI 431



 Score =  199 bits (506), Expect = 4e-51
 Identities = 100/249 (40%), Positives = 145/249 (58%), Gaps = 10/249 (4%)

Query: 205 RCSECGARPLA---SRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMH 261
           +  ECGARP     +R+VGG   A G  PWQ S+  G RH CG +V+  RW+++AAHC  
Sbjct: 488 KLQECGARPAMEKPTRVVGGFGAASGEVPWQVSLKEGSRHFCGATVVGDRWLLSAAHC-- 545

Query: 262 SFRLARLSSWRVHAGLVSHSAVRPHQGAL-VERIIPHPLYSAQNHDYDVALLRLQTALNF 320
            F   ++   R H G  S   +      + + R++ HPLY+    D+D+A+L L + L F
Sbjct: 546 -FNHTKVEQVRAHLGTASLLGLGGSPVKIGLRRVVLHPLYNPGILDFDLAVLELASPLAF 604

Query: 321 SDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVY 380
           +  +  VCLP   Q FP G +C +SGWG+T   +    ++LQ   V +   + C  S +Y
Sbjct: 605 NKYIQPVCLPLAIQKFPVGRKCMISGWGNTQEGNATKPELLQKASVGIIDQKTC--SVLY 662

Query: 381 SGALTPRMLCAGYLDGRADACQGDSGGPLVCPDG-DTWRLVGVVSWGRGCAEPNHPGVYA 439
           + +LT RM+CAG+L+G+ D+CQGDSGGPL C +    + L G+VSWG GCA+   PGVY 
Sbjct: 663 NFSLTDRMICAGFLEGKVDSCQGDSGGPLACEEAPGVFYLAGIVSWGIGCAQVKKPGVYT 722

Query: 440 KVAEFLDWI 448
           ++     WI
Sbjct: 723 RITRLKGWI 731



 Score =  175 bits (443), Expect = 9e-44
 Identities = 102/251 (40%), Positives = 129/251 (51%), Gaps = 11/251 (4%)

Query: 208  ECGARPLA-SRIVGGQSVAPGRWPWQASVALGFR-HTCGGSVLAPRWVVTAAHCMHSFRL 265
            +CG  P A +RIVGG +   G WPWQ S+ L  R H CG  ++A RW+++AAHC   +  
Sbjct: 816  DCGLAPAALTRIVGGSAAGRGEWPWQVSLWLRRREHRCGAVLVAERWLLSAAHCFDVYGD 875

Query: 266  ARLSSWRVHAGLVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVG 325
             +   W    G    S     Q   V RI  HP Y+    DYDVALL L   +  S  V 
Sbjct: 876  PK--QWAAFLGTPFLSGAEG-QLERVARIYKHPFYNLYTLDYDVALLELAGPVRRSRLVR 932

Query: 326  AVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALT 385
             +CLP      P G+RC ++GWG      + +   LQ   V L S Q C     Y   ++
Sbjct: 933  PICLPEPAPRPPDGTRCVITGWGSVREGGSMAR-QLQKAAVRLLSEQTCRR--FYPVQIS 989

Query: 386  PRMLCAGYLDGRADACQGDSGGPLVC--PDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAE 443
             RMLCAG+  G  D+C GD+GGPL C  P G  W L GV SWG GC  P+ PGVY +VA 
Sbjct: 990  SRMLCAGFPQGGVDSCSGDAGGPLACREPSG-RWVLTGVTSWGYGCGRPHFPGVYTRVAA 1048

Query: 444  FLDWIHDTAQD 454
               WI    Q+
Sbjct: 1049 VRGWIGQHIQE 1059


>gi|223942069 enterokinase precursor [Homo sapiens]
          Length = 1019

 Score =  205 bits (522), Expect = 6e-53
 Identities = 115/331 (34%), Positives = 173/331 (52%), Gaps = 18/331 (5%)

Query: 126  RDQPRWLLVCHEGWSPALGLQICWSLGHLRLTHHKGVNLTDIKLNSSQEFAQLSPRLGGF 185
            R Q  W   C E W+  +   +C  LG       K +  TD        F +L+    G 
Sbjct: 694  RIQSIWHTACAENWTTQISNDVCQLLGLGSGNSSKPIFSTD-----GGPFVKLNTAPDGH 748

Query: 186  LEEAWQPRNNCTSGQVVSLRCSE--CG----ARPLASRIVGGQSVAPGRWPWQASVALGF 239
            L     P   C    ++ L+C+   CG    A+ +  +IVGG +   G WPW   +  G 
Sbjct: 749  L--ILTPSQQCLQDSLIRLQCNHKSCGKKLAAQDITPKIVGGSNAKEGAWPWVVGLYYGG 806

Query: 240  RHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVSHSAVRPHQGA--LVERIIPH 297
            R  CG S+++  W+V+AAHC++   L   S W    GL   S +   Q    L++ I+ +
Sbjct: 807  RLLCGASLVSSDWLVSAAHCVYGRNLEP-SKWTAILGLHMKSNLTSPQTVPRLIDEIVIN 865

Query: 298  PLYSAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYS 357
            P Y+ +  D D+A++ L+  +N++D +  +CLP + Q FP G  C ++GWG      T +
Sbjct: 866  PHYNRRRKDNDIAMMHLEFKVNYTDYIQPICLPEENQVFPPGRNCSIAGWGTVVYQGT-T 924

Query: 358  SDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGPLVCPDGDTW 417
            +++LQ+  VPL S + C         +T  M+CAGY +G  D+CQGDSGGPL+C + + W
Sbjct: 925  ANILQEADVPLLSNERCQQQMPEYN-ITENMICAGYEEGGIDSCQGDSGGPLMCQENNRW 983

Query: 418  RLVGVVSWGRGCAEPNHPGVYAKVAEFLDWI 448
             L GV S+G  CA PN PGVYA+V+ F +WI
Sbjct: 984  FLAGVTSFGYKCALPNRPGVYARVSRFTEWI 1014


>gi|78191798 plasma kallikrein B1 precursor [Homo sapiens]
          Length = 638

 Score =  202 bits (514), Expect = 5e-52
 Identities = 99/245 (40%), Positives = 147/245 (60%), Gaps = 8/245 (3%)

Query: 215 ASRIVGGQSVAPGRWPWQASVALGF---RHTCGGSVLAPRWVVTAAHCMHSFRLARLSSW 271
           ++RIVGG + + G WPWQ S+ +     RH CGGS++  +WV+TAAHC     L  +  W
Sbjct: 388 STRIVGGTNSSWGEWPWQVSLQVKLTAQRHLCGGSLIGHQWVLTAAHCFDGLPLQDV--W 445

Query: 272 RVHAGLVSHSAV-RPHQGALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVCLP 330
           R+++G+++ S + +    + ++ II H  Y     ++D+AL++LQ  LN+++    +CLP
Sbjct: 446 RIYSGILNLSDITKDTPFSQIKEIIIHQNYKVSEGNHDIALIKLQAPLNYTEFQKPICLP 505

Query: 331 AKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLC 390
           +K       + CWV+GWG +       + +LQ   +PL + + C         +T RM+C
Sbjct: 506 SKGDTSTIYTNCWVTGWGFSKEKGEIQN-ILQKVNIPLVTNEECQKR-YQDYKITQRMVC 563

Query: 391 AGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWIHD 450
           AGY +G  DAC+GDSGGPLVC     WRLVG+ SWG GCA    PGVY KVAE++DWI +
Sbjct: 564 AGYKEGGKDACKGDSGGPLVCKHNGMWRLVGITSWGEGCARREQPGVYTKVAEYMDWILE 623

Query: 451 TAQDS 455
             Q S
Sbjct: 624 KTQSS 628


>gi|222831592 transmembrane protease, serine 7 [Homo sapiens]
          Length = 717

 Score =  197 bits (500), Expect = 2e-50
 Identities = 99/238 (41%), Positives = 132/238 (55%), Gaps = 11/238 (4%)

Query: 217 RIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAG 276
           RI+GG     G WPWQ S+       CG SV++  W+++AAHC H  RL+  + W  H G
Sbjct: 479 RIIGGTDTLEGGWPWQVSLHFVGSAYCGASVISREWLLSAAHCFHGNRLSDPTPWTAHLG 538

Query: 277 LVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQTAL--NFSDTVGAVCLPAKEQ 334
           +      +    + V RI+ H  Y++Q  DYD+ALL+L  A        +  +C+P   Q
Sbjct: 539 MYVQGNAK--FVSPVRRIVVHEYYNSQTFDYDIALLQLSIAWPETLKQLIQPICIPPTGQ 596

Query: 335 HFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYL 394
               G +CWV+GWG  H +    S +LQ   V L    LC S+    G +T RMLCAG +
Sbjct: 597 RVRSGEKCWVTGWGRRHEADNKGSLVLQQAEVELIDQTLCVST---YGIITSRMLCAGIM 653

Query: 395 DGRADACQGDSGGPLVC---PDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWIH 449
            G+ DAC+GDSGGPL C    DG  W L G+VSWG G   PN PGVY +V+ F+ WIH
Sbjct: 654 SGKRDACKGDSGGPLSCRRKSDG-KWILTGIVSWGHGSGRPNFPGVYTRVSNFVPWIH 710


>gi|4503627 coagulation factor XI precursor [Homo sapiens]
          Length = 625

 Score =  197 bits (500), Expect = 2e-50
 Identities = 97/252 (38%), Positives = 146/252 (57%), Gaps = 11/252 (4%)

Query: 207 SECGARPLASRIVGGQSVAPGRWPWQASVALGF---RHTCGGSVLAPRWVVTAAHCMHSF 263
           +EC  + +  RIVGG +   G WPWQ ++       RH CGGS++  +W++TAAHC +  
Sbjct: 378 NECTTK-IKPRIVGGTASVRGEWPWQVTLHTTSPTQRHLCGGSIIGNQWILTAAHCFYGV 436

Query: 264 RLARLSSWRVHAGLVSHSAVRPHQGAL-VERIIPHPLYSAQNHDYDVALLRLQTALNFSD 322
              ++   RV++G+++ S ++       V+ II H  Y      YD+ALL+L+T +N++D
Sbjct: 437 ESPKIL--RVYSGILNQSEIKEDTSFFGVQEIIIHDQYKMAESGYDIALLKLETTVNYTD 494

Query: 323 TVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSG 382
           +   +CLP+K       + CWV+GWG+         + LQ   +PL + + C     Y G
Sbjct: 495 SQRPICLPSKGDRNVIYTDCWVTGWGY-RKLRDKIQNTLQKAKIPLVTNEECQKR--YRG 551

Query: 383 -ALTPRMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKV 441
             +T +M+CAGY +G  DAC+GDSGGPL C   + W LVG+ SWG GCA+   PGVY  V
Sbjct: 552 HKITHKMICAGYREGGKDACKGDSGGPLSCKHNEVWHLVGITSWGEGCAQRERPGVYTNV 611

Query: 442 AEFLDWIHDTAQ 453
            E++DWI +  Q
Sbjct: 612 VEYVDWILEKTQ 623


>gi|4758508 transmembrane protease, serine 11D [Homo sapiens]
          Length = 418

 Score =  194 bits (494), Expect = 1e-49
 Identities = 104/249 (41%), Positives = 139/249 (55%), Gaps = 14/249 (5%)

Query: 207 SECGARP-----LASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMH 261
           +ECGA P        RI+GG     G WPWQ S+ L   H CGGS++   W++TAAHC  
Sbjct: 171 NECGAGPDLITLSEQRILGGTEAEEGSWPWQVSLRLNNAHHCGGSLINNMWILTAAHCFR 230

Query: 262 SFRLARLSSWRVHAGLVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQTALNFS 321
           S    R   W   +G+   S   P     V  I+ H  Y +  H+ D+AL+RL+ ++ F+
Sbjct: 231 SNSNPR--DWIATSGI---STTFPKLRMRVRNILIHNNYKSATHENDIALVRLENSVTFT 285

Query: 322 DTVGAVCLPAKEQHFPKGSRCWVSGWG-HTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVY 380
             + +VCLPA  Q+ P GS  +V+GWG   +  HT     L+   V + S  +CN+   Y
Sbjct: 286 KDIHSVCLPAATQNIPPGSTAYVTGWGAQEYAGHTVPE--LRQGQVRIISNDVCNAPHSY 343

Query: 381 SGALTPRMLCAGYLDGRADACQGDSGGPLVCPDG-DTWRLVGVVSWGRGCAEPNHPGVYA 439
           +GA+   MLCAG   G  DACQGDSGGPLV  D    W +VG+VSWG  C  P+ PGVY 
Sbjct: 344 NGAILSGMLCAGVPQGGVDACQGDSGGPLVQEDSRRLWFIVGIVSWGDQCGLPDKPGVYT 403

Query: 440 KVAEFLDWI 448
           +V  +LDWI
Sbjct: 404 RVTAYLDWI 412


>gi|4506153 prostasin preproprotein [Homo sapiens]
          Length = 343

 Score =  194 bits (493), Expect = 1e-49
 Identities = 102/249 (40%), Positives = 135/249 (54%), Gaps = 13/249 (5%)

Query: 209 CGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARL 268
           CG  P A RI GG S   G+WPWQ S+     H CGGS+++ +WV++AAHC  S      
Sbjct: 37  CGVAPQA-RITGGSSAVAGQWPWQVSITYEGVHVCGGSLVSEQWVLSAAHCFPSEHHKEA 95

Query: 269 SSWRVHAGLVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVC 328
              ++ A  +  S     + + ++ IIPHP Y  +    D+ALL+L   + FS  +  +C
Sbjct: 96  YEVKLGAHQLD-SYSEDAKVSTLKDIIPHPSYLQEGSQGDIALLQLSRPITFSRYIRPIC 154

Query: 329 LPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDM-LQDTVVPLFSTQLCNSSCVYSGALTPR 387
           LPA    FP G  C V+GWGH  PS +  +   LQ   VPL S + CN  C+Y+    P 
Sbjct: 155 LPAANASFPNGLHCTVTGWGHVAPSVSLLTPKPLQQLEVPLISRETCN--CLYNIDAKPE 212

Query: 388 --------MLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYA 439
                   M+CAGY++G  DACQGDSGGPL CP    W L G+VSWG  C   N PGVY 
Sbjct: 213 EPHFVQEDMVCAGYVEGGKDACQGDSGGPLSCPVEGLWYLTGIVSWGDACGARNRPGVYT 272

Query: 440 KVAEFLDWI 448
             + +  WI
Sbjct: 273 LASSYASWI 281


>gi|117956391 protease, serine, 33 [Homo sapiens]
          Length = 280

 Score =  193 bits (490), Expect = 3e-49
 Identities = 108/254 (42%), Positives = 140/254 (55%), Gaps = 13/254 (5%)

Query: 205 RCSECGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFR 264
           + + CG   ++SRIVGG+    G WPWQAS+     H CGGS++AP+WV+TAAHC    R
Sbjct: 24  KSAACGQPRMSSRIVGGRDGRDGEWPWQASIQHRGAHVCGGSLIAPQWVLTAAHCFP--R 81

Query: 265 LARLSSWRVHAGLVSHSAVRPHQGAL-VERIIPHPLYSAQNHDYDVALLRLQTALNFSDT 323
            A  + +RV  G +   +  P   ++ V R++  P YS      D+ALL+L+  +  S  
Sbjct: 82  RALPAEYRVRLGALRLGSTSPRTLSVPVRRVLLPPDYSEDGARGDLALLQLRRPVPLSAR 141

Query: 324 VGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSS-DMLQDTVVPLFSTQLCNSSCVYSG 382
           V  VCLP      P G+ C V+GWG   P         LQ   VPL  ++ C+    + G
Sbjct: 142 VQPVCLPVPGARPPPGTPCRVTGWGSLRPGVPLPEWRPLQGVRVPLLDSRTCDG-LYHVG 200

Query: 383 A--------LTPRMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNH 434
           A        + P  LCAGY  G  DACQGDSGGPL C    +W LVGVVSWG+GCA PN 
Sbjct: 201 ADVPQAERIVLPGSLCAGYPQGHKDACQGDSGGPLTCLQSGSWVLVGVVSWGKGCALPNR 260

Query: 435 PGVYAKVAEFLDWI 448
           PGVY  VA +  WI
Sbjct: 261 PGVYTSVATYSPWI 274


>gi|11415040 matriptase [Homo sapiens]
          Length = 855

 Score =  191 bits (484), Expect = 2e-48
 Identities = 106/268 (39%), Positives = 148/268 (55%), Gaps = 16/268 (5%)

Query: 193 RNNCTSGQVVSLRCSECGARPLA--SRIVGGQSVAPGRWPWQASV-ALGFRHTCGGSVLA 249
           + +C+ G     +  +CG R     +R+VGG     G WPWQ S+ ALG  H CG S+++
Sbjct: 590 KEDCSDGS--DEKDCDCGLRSFTRQARVVGGTDADEGEWPWQVSLHALGQGHICGASLIS 647

Query: 250 PRWVVTAAHCM---HSFRLARLSSWRVHAGLVSHS--AVRPHQGALVERIIPHPLYSAQN 304
           P W+V+AAHC      FR +  + W    GL   S  +    Q   ++RII HP ++   
Sbjct: 648 PNWLVSAAHCYIDDRGFRYSDPTQWTAFLGLHDQSQRSAPGVQERRLKRIISHPFFNDFT 707

Query: 305 HDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDT 364
            DYD+ALL L+    +S  V  +CLP     FP G   WV+GWGHT    T  + +LQ  
Sbjct: 708 FDYDIALLELEKPAEYSSMVRPICLPDASHVFPAGKAIWVTGWGHTQYGGT-GALILQKG 766

Query: 365 VVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGPL--VCPDGDTWRLVGV 422
            + + +   C +  +    +TPRM+C G+L G  D+CQGDSGGPL  V  DG  ++  GV
Sbjct: 767 EIRVINQTTCEN--LLPQQITPRMMCVGFLSGGVDSCQGDSGGPLSSVEADGRIFQ-AGV 823

Query: 423 VSWGRGCAEPNHPGVYAKVAEFLDWIHD 450
           VSWG GCA+ N PGVY ++  F DWI +
Sbjct: 824 VSWGDGCAQRNKPGVYTRLPLFRDWIKE 851


>gi|187761337 transmembrane protease, serine 11B [Homo sapiens]
          Length = 416

 Score =  191 bits (484), Expect = 2e-48
 Identities = 96/256 (37%), Positives = 149/256 (58%), Gaps = 14/256 (5%)

Query: 194 NNCTSGQVVSLRCSECGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWV 253
           NNC   QV +   +        ++IV G+S   G WPWQAS+    RH CG S+++ RW+
Sbjct: 168 NNCCGRQVANSIIT-------GNKIVNGKSSLEGAWPWQASMQWKGRHYCGASLISSRWL 220

Query: 254 VTAAHCMHSFRLARLSSWRVHAGLVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLR 313
           ++AAHC      ++   W V+ G+V +   +P+    V+ II H  YS+     D+AL++
Sbjct: 221 LSAAHCFAKKNNSK--DWTVNFGIVVN---KPYMTRKVQNIIFHENYSSPGLHDDIALVQ 275

Query: 314 LQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQL 373
           L   ++F++ +  +CLP  +    +     V+GWG  + + ++   +LQ+  + +   ++
Sbjct: 276 LAEEVSFTEYIRKICLPEAKMKLSENDNVVVTGWGTLYMNGSFPV-ILQEDFLKIIDNKI 334

Query: 374 CNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGPLVCPDG-DTWRLVGVVSWGRGCAEP 432
           CN+S  YSG +T  MLCAG++ G ADACQ DSGGPL  PD  + W LVG+VSWG GC + 
Sbjct: 335 CNASYAYSGFVTDTMLCAGFMSGEADACQNDSGGPLAYPDSRNIWHLVGIVSWGDGCGKK 394

Query: 433 NHPGVYAKVAEFLDWI 448
           N PGVY +V  + +WI
Sbjct: 395 NKPGVYTRVTSYRNWI 410


>gi|40254871 transmembrane protease, serine 11E [Homo sapiens]
          Length = 423

 Score =  191 bits (484), Expect = 2e-48
 Identities = 98/234 (41%), Positives = 134/234 (57%), Gaps = 9/234 (3%)

Query: 217 RIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAG 276
           RIVGG  V  G WPWQAS+     H CG +++   W+V+AAHC  +++    + W    G
Sbjct: 191 RIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYK--NPARWTASFG 248

Query: 277 LVSHSAVRPHQGAL-VERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQH 335
           +     ++P +    + RII H  Y   +HDYD++L  L + + +++ V  VCLP     
Sbjct: 249 VT----IKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPDASYE 304

Query: 336 FPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLD 395
           F  G   +V+G+G    +  YS + L+   V L     CN    Y+ A+TPRMLCAG L+
Sbjct: 305 FQPGDVMFVTGFGALK-NDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAGSLE 363

Query: 396 GRADACQGDSGGPLVCPDG-DTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWI 448
           G+ DACQGDSGGPLV  D  D W L G+VSWG  CA+PN PGVY +V    DWI
Sbjct: 364 GKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWI 417


>gi|153791781 transmembrane protease, serine 11E2 [Homo sapiens]
          Length = 423

 Score =  191 bits (484), Expect = 2e-48
 Identities = 98/234 (41%), Positives = 134/234 (57%), Gaps = 9/234 (3%)

Query: 217 RIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAG 276
           RIVGG  V  G WPWQAS+     H CG +++   W+V+AAHC  +++    + W    G
Sbjct: 191 RIVGGTEVEEGEWPWQASLQWDGSHRCGATLINATWLVSAAHCFTTYK--NPARWTASFG 248

Query: 277 LVSHSAVRPHQGAL-VERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQH 335
           +     ++P +    + RII H  Y   +HDYD++L  L + + +++ V  VCLP     
Sbjct: 249 VT----IKPSKMKRGLRRIIVHEKYKHPSHDYDISLAELSSPVPYTNAVHRVCLPDASYE 304

Query: 336 FPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLD 395
           F  G   +V+G+G    +  YS + L+   V L     CN    Y+ A+TPRMLCAG L+
Sbjct: 305 FQPGDVMFVTGFGALK-NDGYSQNHLRQAQVTLIDATTCNEPQAYNDAITPRMLCAGSLE 363

Query: 396 GRADACQGDSGGPLVCPDG-DTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWI 448
           G+ DACQGDSGGPLV  D  D W L G+VSWG  CA+PN PGVY +V    DWI
Sbjct: 364 GKTDACQGDSGGPLVSSDARDIWYLAGIVSWGDECAKPNKPGVYTRVTALRDWI 417


>gi|13994276 marapsin [Homo sapiens]
          Length = 290

 Score =  188 bits (477), Expect = 1e-47
 Identities = 100/252 (39%), Positives = 134/252 (53%), Gaps = 15/252 (5%)

Query: 209 CGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARL 268
           CG   + +R+VGGQ    G WPWQ S+     H CGGS++A +WV+TAAHC  +   +  
Sbjct: 26  CGRPRMLNRMVGGQDTQEGEWPWQVSIQRNGSHFCGGSLIAEQWVLTAAHCFRN--TSET 83

Query: 269 SSWRVHAGLVSHSAVRPH-QGALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAV 327
           S ++V  G        PH   A V ++  +PLY       DVAL+ L+  + F++ +  V
Sbjct: 84  SLYQVLLGARQLVQPGPHAMYARVRQVESNPLYQGTASSADVALVELEAPVPFTNYILPV 143

Query: 328 CLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSD-MLQDTVVPLFSTQLCNSSCVYSG---- 382
           CLP     F  G  CWV+GWG            +LQ   VP+  T  CN   +YS     
Sbjct: 144 CLPDPSVIFETGMNCWVTGWGSPSEEDLLPEPRILQKLAVPIIDTPKCN--LLYSKDTEF 201

Query: 383 -----ALTPRMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGV 437
                 +   MLCAG+ +G+ DAC+GDSGGPLVC  G +W   GV+SWG GCA  N PGV
Sbjct: 202 GYQPKTIKNDMLCAGFEEGKKDACKGDSGGPLVCLVGQSWLQAGVISWGEGCARQNRPGV 261

Query: 438 YAKVAEFLDWIH 449
           Y +V    +WIH
Sbjct: 262 YIRVTAHHNWIH 273


>gi|58218970 protease, serine, 36 [Homo sapiens]
          Length = 855

 Score =  187 bits (475), Expect = 2e-47
 Identities = 112/291 (38%), Positives = 146/291 (50%), Gaps = 24/291 (8%)

Query: 178 LSPRLGGFLEEAWQPRNNCTSGQVVSLRCSECGARPLASRIVGGQSVAPGRWPWQASVAL 237
           +SP  G F + A  P    T  +   L   +CG    ++RIVGG +  PG WPWQ S+  
Sbjct: 14  ISPIPGAFQDSALSP----TQEEPEDL---DCGRPEPSARIVGGSNAQPGTWPWQVSLHH 66

Query: 238 GFRHTCGGSVLAPRWVVTAAHC-MHSFRLARLSSWRVHAGLVSHSAVRPHQGA---LVER 293
           G  H CGGS++AP WV++AAHC M +  L   + W V  G+  HS   P  GA    V  
Sbjct: 67  GGGHICGGSLIAPSWVLSAAHCFMTNGTLEPAAEWSVLLGV--HSQDGPLDGAHTRAVAA 124

Query: 294 IIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPS 353
           I+    YS      D+ALLRL +  +    V  VCLP     F  G+ CW +GWG    +
Sbjct: 125 IVVPANYSQVELGADLALLRLASPASLGPAVWPVCLPRASHRFVHGTACWATGWGDVQEA 184

Query: 354 HTYSSD-MLQDTVVPLFSTQLCNSSCVYSGA--------LTPRMLCAGYLDGRADACQGD 404
                  +LQ+  + L     C   C+YS          + P MLCAGY +GR D CQGD
Sbjct: 185 DPLPLPWVLQEVELRLLGEATCQ--CLYSQPGPFNLTLQILPGMLCAGYPEGRRDTCQGD 242

Query: 405 SGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWIHDTAQDS 455
           SGGPLVC +G  W   G+ S+G GC   N PGV+  VA +  WI +    S
Sbjct: 243 SGGPLVCEEGGRWFQAGITSFGFGCGRRNRPGVFTAVATYEAWIREQVMGS 293



 Score = 89.7 bits (221), Expect = 5e-18
 Identities = 77/257 (29%), Positives = 109/257 (42%), Gaps = 46/257 (17%)

Query: 191 QPRN-NCTSGQVVSLRCSECGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLA 249
           +PR  NCT      +   ECG  P            PG WPW+A V +     C G++++
Sbjct: 312 EPREENCT------IALPECGKAP-----------RPGAWPWEAQVMVPGSRPCHGALVS 354

Query: 250 PRWVVTAAHCMHSFRLAR-----LSSWRVHAGLVSHSAVRPHQGALVERIIPHPLYSAQN 304
             WV+  A C      +      L +WRV          RP +   V R++ H   S  N
Sbjct: 355 ESWVLAPASCFLDPNSSDSPPRDLDAWRVLL------PSRP-RAERVARLVQHENASWDN 407

Query: 305 HDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDT 364
              D+ALL+L+T +N S     VCLP  E +F  GSRC ++ WG   P+      +L+  
Sbjct: 408 AS-DLALLQLRTPVNLSAASRPVCLPHPEHYFLPGSRCRLARWGRGEPA-LGPGALLE-- 463

Query: 365 VVPLFSTQLCNSSCVY--SGALT------PRMLCAGYLD-GRADACQGDSGGPLVCPDGD 415
              L     C+  C+Y   GA        P  LC  Y +     +C  DS   L+C +  
Sbjct: 464 -AELLGGWWCH--CLYGRQGAAVPLPGDPPHALCPAYQEKEEVGSCWNDSRWSLLCQEEG 520

Query: 416 TWRLVGVVSWGRGCAEP 432
           TW L G+  +  GC  P
Sbjct: 521 TWFLAGIRDFPSGCLRP 537



 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 61/201 (30%), Positives = 92/201 (45%), Gaps = 16/201 (7%)

Query: 229 WPWQASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVSHSAVRPHQG 288
           WPW A V +     C G +LAP WV+ A HC+       +    V+ G    S++   QG
Sbjct: 601 WPWLAEVHVAGDRVCTGILLAPGWVLAATHCVLRPGSTTVPYIEVYLGRAGASSL--PQG 658

Query: 289 ALVER-IIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVCL-PAKEQHFPKGSRCWVSG 346
             V R +I   L         +ALL L + +  S +   +CL PA     P G+ CWV G
Sbjct: 659 HQVSRLVISIRLPQHLGLRPPLALLELSSRVEPSPSALPICLHPA---GIPPGASCWVLG 715

Query: 347 WGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSG 406
           W         ++       V + + ++C+  C+Y G L P  LC  Y +G+ + C+  S 
Sbjct: 716 WKEPQDRVPVAA------AVSILTQRICD--CLYQGILPPGTLCVLYAEGQENRCEMTSA 767

Query: 407 GPLVCPDGD-TWRLVGVVSWG 426
            PL+C   + +W LVG+   G
Sbjct: 768 PPLLCQMTEGSWILVGMAVQG 788


>gi|29244926 corin [Homo sapiens]
          Length = 1042

 Score =  186 bits (472), Expect = 4e-47
 Identities = 127/371 (34%), Positives = 186/371 (50%), Gaps = 35/371 (9%)

Query: 93   CSEASAEEALLPALPKTVSFRINSEDFLLEAQVRDQPRWLLVCHEGWSPALGLQICWSLG 152
            CS++S E   +     T+S  +NS  FL+  +   +     VC +GW   L    C  +G
Sbjct: 680  CSDSSDEWDCV-----TLSINVNSSSFLMVHRAATEHH---VCADGWQEILSQLACKQMG 731

Query: 153  H-----LRLTHHKGVNLTDIKLNSSQEFAQLSPRLGGFLEEAWQPRNNCTSGQVVSLRCS 207
                   +L   +      + L+S+ E        G  L E      +C S   +SL C+
Sbjct: 732  LGEPSVTKLIQEQEKEPRWLTLHSNWESLN-----GTTLHELLVNGQSCESRSKISLLCT 786

Query: 208  --ECGARPLA---SRIVGGQSVAPGRWPWQASV-ALGFRHTCGGSVLAPRWVVTAAHCMH 261
              +CG RP A    RI+GG++  PGRWPWQ S+ +    H CG  ++A +WV+T AHC  
Sbjct: 787  KQDCGRRPAARMNKRILGGRTSRPGRWPWQCSLQSEPSGHICGCVLIAKKWVLTVAHCFE 846

Query: 262  SFRLARLSSWRVHAGL--VSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQTALN 319
                A +  W+V  G+  + H +V   Q   V+ II HP YS    DYD++++ L   ++
Sbjct: 847  GRENAAV--WKVVLGINNLDHPSVFM-QTRFVKTIILHPRYSRAVVDYDISIVELSEDIS 903

Query: 320  FSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCV 379
             +  V  VCLP  EQ     + C+++GWGH      +    LQ+  V + S + C S   
Sbjct: 904  ETGYVRPVCLPNPEQWLEPDTYCYITGWGHMGNKMPFK---LQEGEVRIISLEHCQSYFD 960

Query: 380  YSGALTPRMLCAGYLDGRADACQGDSGGPLVC-PDGDTWRLVGVVSWGRGC-AEPNHPGV 437
                +T RM+CAGY  G  D+C GDSGGPLVC   G  W L G+ SWG  C ++   PGV
Sbjct: 961  MK-TITTRMICAGYESGTVDSCMGDSGGPLVCEKPGGRWTLFGLTSWGSVCFSKVLGPGV 1019

Query: 438  YAKVAEFLDWI 448
            Y+ V+ F++WI
Sbjct: 1020 YSNVSYFVEWI 1030


>gi|11545839 protease, serine, 22 [Homo sapiens]
          Length = 317

 Score =  184 bits (467), Expect = 1e-46
 Identities = 98/253 (38%), Positives = 133/253 (52%), Gaps = 11/253 (4%)

Query: 209 CGARPLASRIVGGQSVAPGRWPWQASVALGFRHTCGGSVLAPRWVVTAAHCMH-SFRLAR 267
           CG     +R+VGG+      WPW  S+     H C GS+L  RWV+TAAHC   +     
Sbjct: 41  CGKPQQLNRVVGGEDSTDSEWPWIVSIQKNGTHHCAGSLLTSRWVITAAHCFKDNLNKPY 100

Query: 268 LSSWRVHAGLVSHSAVRPHQGALVERIIPHPLYS-AQNHDYDVALLRLQTALNFSDTVGA 326
           L S  + A  + +   R  Q   V  + PHP+YS  +    D+AL+RL+ ++ FS+ V  
Sbjct: 101 LFSVLLGAWQLGNPGSRS-QKVGVAWVEPHPVYSWKEGACADIALVRLERSIQFSERVLP 159

Query: 327 VCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDM-LQDTVVPLFSTQLCNSSCVY----- 380
           +CLP    H P  + CW+SGWG             LQ   VP+  +++C  S +Y     
Sbjct: 160 ICLPDASIHLPPNTHCWISGWGSIQDGVPLPHPQTLQKLKVPIIDSEVC--SHLYWRGAG 217

Query: 381 SGALTPRMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAK 440
            G +T  MLCAGYL+G  DAC GDSGGPL+C     W L G++SWG GCAE N PGVY  
Sbjct: 218 QGPITEDMLCAGYLEGERDACLGDSGGPLMCQVDGAWLLAGIISWGEGCAERNRPGVYIS 277

Query: 441 VAEFLDWIHDTAQ 453
           ++    W+    Q
Sbjct: 278 LSAHRSWVEKIVQ 290


>gi|194018492 transmembrane protease, serine 11F [Homo sapiens]
          Length = 438

 Score =  181 bits (459), Expect = 1e-45
 Identities = 103/265 (38%), Positives = 151/265 (56%), Gaps = 21/265 (7%)

Query: 198 SGQVVSLRCSECGARPLAS-----------RIVGGQSVA-PGRWPWQASVAL-GFRHTCG 244
           S ++ +L  S CG R  +S           RIV G+  A  G WPWQAS+ L G  H CG
Sbjct: 175 SKKMRNLLNSRCGIRMTSSNMPLPASSSTQRIVQGRETAMEGEWPWQASLQLIGSGHQCG 234

Query: 245 GSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGL-VSHSAVRPHQGALVERIIPHPLYSAQ 303
            S+++  W++TAAHC   ++    + W    G  ++  AV+ +    V +II H  Y  +
Sbjct: 235 ASLISNTWLLTAAHCF--WKNKDPTQWIATFGATITPPAVKRN----VRKIILHENYHRE 288

Query: 304 NHDYDVALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQD 363
            ++ D+AL++L T + FS+ V  VCLP      P  +  +V+G+G         + + Q 
Sbjct: 289 TNENDIALVQLSTGVEFSNIVQRVCLPDSSIKLPPKTSVFVTGFGSIVDDGPIQNTLRQA 348

Query: 364 TVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVV 423
            V  + ST +CN   VY G +TP MLCAG+++G+ DAC+GDSGGPLV  + D W +VG+V
Sbjct: 349 RVETI-STDVCNRKDVYDGLITPGMLCAGFMEGKIDACKGDSGGPLVYDNHDIWYIVGIV 407

Query: 424 SWGRGCAEPNHPGVYAKVAEFLDWI 448
           SWG+ CA P  PGVY +V ++ DWI
Sbjct: 408 SWGQSCALPKKPGVYTRVTKYRDWI 432


>gi|68508970 tryptase beta 2 precursor [Homo sapiens]
          Length = 275

 Score =  180 bits (457), Expect = 2e-45
 Identities = 101/243 (41%), Positives = 131/243 (53%), Gaps = 16/243 (6%)

Query: 218 IVGGQSVAPGRWPWQASVALGFR---HTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVH 274
           IVGGQ     +WPWQ S+ +  R   H CGGS++ P+WV+TAAHC+    +  L++ RV 
Sbjct: 31  IVGGQEAPRSKWPWQVSLRVRDRYWMHFCGGSLIHPQWVLTAAHCVGP-DVKDLAALRVQ 89

Query: 275 AGLVSHSAVRPHQGALVERIIPHPLYSAQNHDYDVALLRLQTALNFSDTVGAVCLPAKEQ 334
             L         Q   V RII HP +       D+ALL L+  +N S  V  V LP   +
Sbjct: 90  --LREQHLYYQDQLLPVSRIIVHPQFYTAQIGADIALLELEEPVNVSSHVHTVTLPPASE 147

Query: 335 HFPKGSRCWVSGWGHTHPSHTYSSDM-LQDTVVPLFSTQLCNSSC---VYSG----ALTP 386
            FP G  CWV+GWG             L+   VP+    +C++      Y+G     +  
Sbjct: 148 TFPPGMPCWVTGWGDVDNDERLPPPFPLKQVKVPIMENHICDAKYHLGAYTGDDVRIVRD 207

Query: 387 RMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLD 446
            MLCAG  + R D+CQGDSGGPLVC    TW   GVVSWG GCA+PN PG+Y +V  +LD
Sbjct: 208 DMLCAG--NTRRDSCQGDSGGPLVCKVNGTWLQAGVVSWGEGCAQPNRPGIYTRVTYYLD 265

Query: 447 WIH 449
           WIH
Sbjct: 266 WIH 268


>gi|4504383 HGF activator preproprotein [Homo sapiens]
          Length = 655

 Score =  180 bits (457), Expect = 2e-45
 Identities = 109/284 (38%), Positives = 146/284 (51%), Gaps = 24/284 (8%)

Query: 177 QLSPRLGGFLEEAWQPRNNCTSGQVVSLRCSECGARP-----LASRIVGGQSVAPGRWPW 231
           QLSP L   L E   P                CG R      L  RI+GG S  PG  PW
Sbjct: 374 QLSPDLLATLPEPASPGRQA------------CGRRHKKRTFLRPRIIGGSSSLPGSHPW 421

Query: 232 QASVALGFRHTCGGSVLAPRWVVTAAHCMHSFRLARLSSWRVHAGLVSHSAVRPHQGALV 291
            A++ +G    C GS++   WVV+AAHC  S    R S   V      +      Q   +
Sbjct: 422 LAAIYIGDSF-CAGSLVHTCWVVSAAHCF-SHSPPRDSVSVVLGQHFFNRTTDVTQTFGI 479

Query: 292 ERIIPHPLYSAQN-HDYDVALLRLQT----ALNFSDTVGAVCLPAKEQHFPKGSRCWVSG 346
           E+ IP+ LYS  N  D+D+ L+RL+         S  V  +CLP     FP G +C ++G
Sbjct: 480 EKYIPYTLYSVFNPSDHDLVLIRLKKKGDRCATRSQFVQPICLPEPGSTFPAGHKCQIAG 539

Query: 347 WGHTHPSHTYSSDMLQDTVVPLFSTQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSG 406
           WGH   + +  S  L++ +VPL +   C+S  VY   ++P MLCAGY D ++DACQGDSG
Sbjct: 540 WGHLDENVSGYSSSLREALVPLVADHKCSSPEVYGADISPNMLCAGYFDCKSDACQGDSG 599

Query: 407 GPLVCPDGDTWRLVGVVSWGRGCAEPNHPGVYAKVAEFLDWIHD 450
           GPL C       L G++SWG GC   + PGVY +VA ++DWI+D
Sbjct: 600 GPLACEKNGVAYLYGIISWGDGCGRLHKPGVYTRVANYVDWIND 643


>gi|4505881 plasminogen [Homo sapiens]
          Length = 810

 Score =  180 bits (456), Expect = 3e-45
 Identities = 98/266 (36%), Positives = 143/266 (53%), Gaps = 20/266 (7%)

Query: 192 PRNNCTSGQVVSLRCSECGARPLASRIVGGQSVAPGRWPWQASVALGF-RHTCGGSVLAP 250
           P  +C   QV   +C          R+VGG    P  WPWQ S+   F  H CGG++++P
Sbjct: 563 PSFDCGKPQVEPKKCP--------GRVVGGCVAHPHSWPWQVSLRTRFGMHFCGGTLISP 614

Query: 251 RWVVTAAHCMHSFRLARLSSWRVHAGLVSHSAVRPH-QGALVERIIPHPLYSAQNHDYDV 309
            WV+TAAHC+   +  R SS++V  G      + PH Q   V R+   P         D+
Sbjct: 615 EWVLTAAHCLE--KSPRPSSYKVILGAHQEVNLEPHVQEIEVSRLFLEPTRK------DI 666

Query: 310 ALLRLQTALNFSDTVGAVCLPAKEQHFPKGSRCWVSGWGHTHPSHTYSSDMLQDTVVPLF 369
           ALL+L +    +D V   CLP+        + C+++GWG T    T+ + +L++  +P+ 
Sbjct: 667 ALLKLSSPAVITDKVIPACLPSPNYVVADRTECFITGWGETQG--TFGAGLLKEAQLPVI 724

Query: 370 STQLCNSSCVYSGALTPRMLCAGYLDGRADACQGDSGGPLVCPDGDTWRLVGVVSWGRGC 429
             ++CN     +G +    LCAG+L G  D+CQGDSGGPLVC + D + L GV SWG GC
Sbjct: 725 ENKVCNRYEFLNGRVQSTELCAGHLAGGTDSCQGDSGGPLVCFEKDKYILQGVTSWGLGC 784

Query: 430 AEPNHPGVYAKVAEFLDWIHDTAQDS 455
           A PN PGVY +V+ F+ WI    +++
Sbjct: 785 ARPNKPGVYVRVSRFVTWIEGVMRNN 810


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.321    0.135    0.448 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 20,276,254
Number of Sequences: 37866
Number of extensions: 982835
Number of successful extensions: 2886
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 165
Number of HSP's successfully gapped in prelim test: 14
Number of HSP's that attempted gapping in prelim test: 2177
Number of HSP's gapped (non-prelim): 227
length of query: 457
length of database: 18,247,518
effective HSP length: 106
effective length of query: 351
effective length of database: 14,233,722
effective search space: 4996036422
effective search space used: 4996036422
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 64 (29.3 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.