Guide to the Human Genome
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Search of human proteins with 169636415

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|169636415 complement component 6 precursor [Homo sapiens]
         (934 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|189242612 complement component 6 precursor [Homo sapiens]         1979   0.0  
gi|169636415 complement component 6 precursor [Homo sapiens]         1979   0.0  
gi|45580688 complement component 7 precursor [Homo sapiens]           454   e-127
gi|4557389 complement component 8, alpha polypeptide precursor [...   307   3e-83
gi|4557391 complement component 8, beta polypeptide preproprotei...   286   5e-77
gi|4502511 complement component 9 precursor [Homo sapiens]            225   2e-58
gi|133908621 perforin 1 precursor [Homo sapiens]                       87   9e-17
gi|40254808 perforin 1 precursor [Homo sapiens]                        87   9e-17
gi|148886654 polydom [Homo sapiens]                                    67   6e-11
gi|86793109 complement receptor 1 isoform S precursor [Homo sapi...    67   1e-10
gi|86793036 complement receptor 1 isoform F precursor [Homo sapi...    67   1e-10
gi|209977117 unc-5 homolog D [Homo sapiens]                            65   4e-10
gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens]      64   7e-10
gi|147904700 semaphorin 5A [Homo sapiens]                              63   1e-09
gi|42544177 complement component (3d/Epstein Barr virus) recepto...    62   3e-09
gi|54792123 complement component (3d/Epstein Barr virus) recepto...    62   3e-09
gi|118572606 hemicentin 1 [Homo sapiens]                               62   3e-09
gi|40317628 thrombospondin 2 precursor [Homo sapiens]                  62   3e-09
gi|150170672 thrombospondin, type I, domain containing 7A [Homo ...    62   3e-09
gi|16933525 unc5C [Homo sapiens]                                       60   7e-09
gi|4502503 complement component 4 binding protein, alpha chain p...    60   7e-09
gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [...    60   1e-08
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo...    59   2e-08
gi|134031945 SCO-spondin [Homo sapiens]                                59   2e-08
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot...    59   3e-08
gi|62243567 netrin receptor Unc5h1 [Homo sapiens]                      59   3e-08
gi|110347423 spondin 1, extracellular matrix protein [Homo sapiens]    58   4e-08
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot...    58   4e-08
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot...    58   5e-08
gi|110611237 coagulation factor XIII B subunit precursor [Homo s...    58   5e-08

>gi|189242612 complement component 6 precursor [Homo sapiens]
          Length = 934

 Score = 1979 bits (5127), Expect = 0.0
 Identities = 934/934 (100%), Positives = 934/934 (100%)

Query: 1   MARRSVLYFILLNALINKGQACFCDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENF 60
           MARRSVLYFILLNALINKGQACFCDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENF
Sbjct: 1   MARRSVLYFILLNALINKGQACFCDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENF 60

Query: 61  CEQICSKQETRECNWQRCPINCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAP 120
           CEQICSKQETRECNWQRCPINCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAP
Sbjct: 61  CEQICSKQETRECNWQRCPINCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAP 120

Query: 121 LVAFQPCIPSKLCKIEEADCKNKFRCDSGRCIARKLECNGENDCGDNSDERDCGRTKAVC 180
           LVAFQPCIPSKLCKIEEADCKNKFRCDSGRCIARKLECNGENDCGDNSDERDCGRTKAVC
Sbjct: 121 LVAFQPCIPSKLCKIEEADCKNKFRCDSGRCIARKLECNGENDCGDNSDERDCGRTKAVC 180

Query: 181 TRKYNPIPSVQLMGNGFHFLAGEPRGEVLDNSFTGGICKTVKSSRTSNPYRVPANLENVG 240
           TRKYNPIPSVQLMGNGFHFLAGEPRGEVLDNSFTGGICKTVKSSRTSNPYRVPANLENVG
Sbjct: 181 TRKYNPIPSVQLMGNGFHFLAGEPRGEVLDNSFTGGICKTVKSSRTSNPYRVPANLENVG 240

Query: 241 FEVQTAEDDLKTDFYKDLTSLGHNENQQGSFSSQGGSSFSVPIFYSSKRSENINHNSAFK 300
           FEVQTAEDDLKTDFYKDLTSLGHNENQQGSFSSQGGSSFSVPIFYSSKRSENINHNSAFK
Sbjct: 241 FEVQTAEDDLKTDFYKDLTSLGHNENQQGSFSSQGGSSFSVPIFYSSKRSENINHNSAFK 300

Query: 301 QAIQASHKKDSSFIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPLEYNSALYSRIFDD 360
           QAIQASHKKDSSFIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPLEYNSALYSRIFDD
Sbjct: 301 QAIQASHKKDSSFIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPLEYNSALYSRIFDD 360

Query: 361 FGTHYFTSGSLGGVYDLLYQFSSEELKNSGLTEEEAKHCVRIETKKRVLFAKKTKVEHRC 420
           FGTHYFTSGSLGGVYDLLYQFSSEELKNSGLTEEEAKHCVRIETKKRVLFAKKTKVEHRC
Sbjct: 361 FGTHYFTSGSLGGVYDLLYQFSSEELKNSGLTEEEAKHCVRIETKKRVLFAKKTKVEHRC 420

Query: 421 TTNKLSEKHEGSFIQGAEKSISLIRGGRSEYGAALAWEKGSSGLEEKTFSEWLESVKENP 480
           TTNKLSEKHEGSFIQGAEKSISLIRGGRSEYGAALAWEKGSSGLEEKTFSEWLESVKENP
Sbjct: 421 TTNKLSEKHEGSFIQGAEKSISLIRGGRSEYGAALAWEKGSSGLEEKTFSEWLESVKENP 480

Query: 481 AVIDFELAPIVDLVRNIPCAVTKRNNLRKALQEYAAKFDPCQCAPCPNNGRPTLSGTECL 540
           AVIDFELAPIVDLVRNIPCAVTKRNNLRKALQEYAAKFDPCQCAPCPNNGRPTLSGTECL
Sbjct: 481 AVIDFELAPIVDLVRNIPCAVTKRNNLRKALQEYAAKFDPCQCAPCPNNGRPTLSGTECL 540

Query: 541 CVCQSGTYGENCEKQSPDYKSNAVDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKR 600
           CVCQSGTYGENCEKQSPDYKSNAVDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKR
Sbjct: 541 CVCQSGTYGENCEKQSPDYKSNAVDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKR 600

Query: 601 CEGEKRQEEDCTFSIMENNGQPCINDDEEMKEVDLPEIEADSGCPQPVPPENGFIRNEKQ 660
           CEGEKRQEEDCTFSIMENNGQPCINDDEEMKEVDLPEIEADSGCPQPVPPENGFIRNEKQ
Sbjct: 601 CEGEKRQEEDCTFSIMENNGQPCINDDEEMKEVDLPEIEADSGCPQPVPPENGFIRNEKQ 660

Query: 661 LYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQR 720
           LYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQR
Sbjct: 661 LYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQR 720

Query: 721 LYRIGESIELTCPKGFVVAGPSRYTCQGNSWTPPISNSLTCEKDTLTKLKGHCQLGQKQS 780
           LYRIGESIELTCPKGFVVAGPSRYTCQGNSWTPPISNSLTCEKDTLTKLKGHCQLGQKQS
Sbjct: 721 LYRIGESIELTCPKGFVVAGPSRYTCQGNSWTPPISNSLTCEKDTLTKLKGHCQLGQKQS 780

Query: 781 GSECICMSPEEDCSHHSEDLCVFDTDSNDYFTSPACKFLAEKCLNNQQLHFLHIGSCQDG 840
           GSECICMSPEEDCSHHSEDLCVFDTDSNDYFTSPACKFLAEKCLNNQQLHFLHIGSCQDG
Sbjct: 781 GSECICMSPEEDCSHHSEDLCVFDTDSNDYFTSPACKFLAEKCLNNQQLHFLHIGSCQDG 840

Query: 841 RQLEWGLERTRLSSNSTKKESCGYDTCYDWEKCSASTSKCVCLLPPQCFKGGNQLYCVKM 900
           RQLEWGLERTRLSSNSTKKESCGYDTCYDWEKCSASTSKCVCLLPPQCFKGGNQLYCVKM
Sbjct: 841 RQLEWGLERTRLSSNSTKKESCGYDTCYDWEKCSASTSKCVCLLPPQCFKGGNQLYCVKM 900

Query: 901 GSSTSEKTLNICEVGTIRCANRKMEILHPGKCLA 934
           GSSTSEKTLNICEVGTIRCANRKMEILHPGKCLA
Sbjct: 901 GSSTSEKTLNICEVGTIRCANRKMEILHPGKCLA 934


>gi|169636415 complement component 6 precursor [Homo sapiens]
          Length = 934

 Score = 1979 bits (5127), Expect = 0.0
 Identities = 934/934 (100%), Positives = 934/934 (100%)

Query: 1   MARRSVLYFILLNALINKGQACFCDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENF 60
           MARRSVLYFILLNALINKGQACFCDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENF
Sbjct: 1   MARRSVLYFILLNALINKGQACFCDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENF 60

Query: 61  CEQICSKQETRECNWQRCPINCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAP 120
           CEQICSKQETRECNWQRCPINCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAP
Sbjct: 61  CEQICSKQETRECNWQRCPINCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAP 120

Query: 121 LVAFQPCIPSKLCKIEEADCKNKFRCDSGRCIARKLECNGENDCGDNSDERDCGRTKAVC 180
           LVAFQPCIPSKLCKIEEADCKNKFRCDSGRCIARKLECNGENDCGDNSDERDCGRTKAVC
Sbjct: 121 LVAFQPCIPSKLCKIEEADCKNKFRCDSGRCIARKLECNGENDCGDNSDERDCGRTKAVC 180

Query: 181 TRKYNPIPSVQLMGNGFHFLAGEPRGEVLDNSFTGGICKTVKSSRTSNPYRVPANLENVG 240
           TRKYNPIPSVQLMGNGFHFLAGEPRGEVLDNSFTGGICKTVKSSRTSNPYRVPANLENVG
Sbjct: 181 TRKYNPIPSVQLMGNGFHFLAGEPRGEVLDNSFTGGICKTVKSSRTSNPYRVPANLENVG 240

Query: 241 FEVQTAEDDLKTDFYKDLTSLGHNENQQGSFSSQGGSSFSVPIFYSSKRSENINHNSAFK 300
           FEVQTAEDDLKTDFYKDLTSLGHNENQQGSFSSQGGSSFSVPIFYSSKRSENINHNSAFK
Sbjct: 241 FEVQTAEDDLKTDFYKDLTSLGHNENQQGSFSSQGGSSFSVPIFYSSKRSENINHNSAFK 300

Query: 301 QAIQASHKKDSSFIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPLEYNSALYSRIFDD 360
           QAIQASHKKDSSFIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPLEYNSALYSRIFDD
Sbjct: 301 QAIQASHKKDSSFIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPLEYNSALYSRIFDD 360

Query: 361 FGTHYFTSGSLGGVYDLLYQFSSEELKNSGLTEEEAKHCVRIETKKRVLFAKKTKVEHRC 420
           FGTHYFTSGSLGGVYDLLYQFSSEELKNSGLTEEEAKHCVRIETKKRVLFAKKTKVEHRC
Sbjct: 361 FGTHYFTSGSLGGVYDLLYQFSSEELKNSGLTEEEAKHCVRIETKKRVLFAKKTKVEHRC 420

Query: 421 TTNKLSEKHEGSFIQGAEKSISLIRGGRSEYGAALAWEKGSSGLEEKTFSEWLESVKENP 480
           TTNKLSEKHEGSFIQGAEKSISLIRGGRSEYGAALAWEKGSSGLEEKTFSEWLESVKENP
Sbjct: 421 TTNKLSEKHEGSFIQGAEKSISLIRGGRSEYGAALAWEKGSSGLEEKTFSEWLESVKENP 480

Query: 481 AVIDFELAPIVDLVRNIPCAVTKRNNLRKALQEYAAKFDPCQCAPCPNNGRPTLSGTECL 540
           AVIDFELAPIVDLVRNIPCAVTKRNNLRKALQEYAAKFDPCQCAPCPNNGRPTLSGTECL
Sbjct: 481 AVIDFELAPIVDLVRNIPCAVTKRNNLRKALQEYAAKFDPCQCAPCPNNGRPTLSGTECL 540

Query: 541 CVCQSGTYGENCEKQSPDYKSNAVDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKR 600
           CVCQSGTYGENCEKQSPDYKSNAVDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKR
Sbjct: 541 CVCQSGTYGENCEKQSPDYKSNAVDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKR 600

Query: 601 CEGEKRQEEDCTFSIMENNGQPCINDDEEMKEVDLPEIEADSGCPQPVPPENGFIRNEKQ 660
           CEGEKRQEEDCTFSIMENNGQPCINDDEEMKEVDLPEIEADSGCPQPVPPENGFIRNEKQ
Sbjct: 601 CEGEKRQEEDCTFSIMENNGQPCINDDEEMKEVDLPEIEADSGCPQPVPPENGFIRNEKQ 660

Query: 661 LYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQR 720
           LYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQR
Sbjct: 661 LYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQR 720

Query: 721 LYRIGESIELTCPKGFVVAGPSRYTCQGNSWTPPISNSLTCEKDTLTKLKGHCQLGQKQS 780
           LYRIGESIELTCPKGFVVAGPSRYTCQGNSWTPPISNSLTCEKDTLTKLKGHCQLGQKQS
Sbjct: 721 LYRIGESIELTCPKGFVVAGPSRYTCQGNSWTPPISNSLTCEKDTLTKLKGHCQLGQKQS 780

Query: 781 GSECICMSPEEDCSHHSEDLCVFDTDSNDYFTSPACKFLAEKCLNNQQLHFLHIGSCQDG 840
           GSECICMSPEEDCSHHSEDLCVFDTDSNDYFTSPACKFLAEKCLNNQQLHFLHIGSCQDG
Sbjct: 781 GSECICMSPEEDCSHHSEDLCVFDTDSNDYFTSPACKFLAEKCLNNQQLHFLHIGSCQDG 840

Query: 841 RQLEWGLERTRLSSNSTKKESCGYDTCYDWEKCSASTSKCVCLLPPQCFKGGNQLYCVKM 900
           RQLEWGLERTRLSSNSTKKESCGYDTCYDWEKCSASTSKCVCLLPPQCFKGGNQLYCVKM
Sbjct: 841 RQLEWGLERTRLSSNSTKKESCGYDTCYDWEKCSASTSKCVCLLPPQCFKGGNQLYCVKM 900

Query: 901 GSSTSEKTLNICEVGTIRCANRKMEILHPGKCLA 934
           GSSTSEKTLNICEVGTIRCANRKMEILHPGKCLA
Sbjct: 901 GSSTSEKTLNICEVGTIRCANRKMEILHPGKCLA 934


>gi|45580688 complement component 7 precursor [Homo sapiens]
          Length = 843

 Score =  454 bits (1168), Expect = e-127
 Identities = 281/871 (32%), Positives = 432/871 (49%), Gaps = 70/871 (8%)

Query: 79  PINCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAPLVAFQPCIPSKLCKIEEA 138
           P+NC    + PWS+C+ C + Q++ RSV    Q+GGQPC       Q C P++ C  EE 
Sbjct: 25  PVNCQWDFYAPWSECNGCTKTQTRRRSVAVYGQYGGQPCVGNAFETQSCEPTRGCPTEEG 84

Query: 139 DCKNKFRCDSGRCIARKLECNGENDCG-DNSDERDC--GRTKAVCTRKYNPIPSVQLMGN 195
            C  +FRC SG+CI++ L CNG++DC  D++DE  C     +  C     P P+++L GN
Sbjct: 85  -CGERFRCFSGQCISKSLVCNGDSDCDEDSADEDRCEDSERRPSCDID-KPPPNIELTGN 142

Query: 196 GFHFLAGEPRGEVLDNSFTGGICKTVKSSRTSNPYRVPANLENVGFEVQTAEDDLKTDFY 255
           G++ L G+ R  V++    GG C+ V S    + YR+  N+ +  F+V+   +D   +FY
Sbjct: 143 GYNELTGQFRNRVINTKSFGGQCRKVFSGDGKDFYRLSGNVLSYTFQVKI-NNDFNYEFY 201

Query: 256 KDLTSLGHNENQQGSFSSQGGSSFSVPIFYSSKRSENINHNSAFKQAIQASHKKDSSFIR 315
               S   + + + + SS+  S F      SS RS   + N   K        K    + 
Sbjct: 202 NSTWSYVKHTSTEHTSSSRKRSFFRSSS--SSSRSYTSHTNEIHKG-------KSYQLLV 252

Query: 316 IHKVMKVLNFTTKAKD-LHLSDVFLKALNHLPLEYNSALYSRIFDDFGTHYFTSGSLGGV 374
           +   ++V  F     + L L++ F K L+HLP  Y+ + Y R+ D +GTHY  SGSLGG 
Sbjct: 253 VENTVEVAQFINNNPEFLQLAEPFWKELSHLPSLYDYSAYRRLIDQYGTHYLQSGSLGGE 312

Query: 375 YDLLYQFSSEELKNSGLTEEEAKHCVRIETKKRVLFAKKTKVEHRCTTNKLSEKHEGSFI 434
           Y +L+   SE+LK +     E K C        V F+      H C   + + K      
Sbjct: 313 YRVLFYVDSEKLKQNDFNSVEEKKCKSSGWHFVVKFSS-----HGCKELENALKAASGTQ 367

Query: 435 QGAEKSISLIRGGRSEYGAALAW-EKGSSGLEEKTFSEWLESVKENPAVIDFELAPIVDL 493
               +    IRGG + + + L++ E  +    ++ +S W ESV   P VI  +L P+ +L
Sbjct: 368 NNVLRGEPFIRGGGAGFISGLSYLELDNPAGNKRRYSAWAESVTNLPQVIKQKLTPLYEL 427

Query: 494 VRNIPCAVTKRNNLRKALQEYAAKFDPCQCAPCPNNGRPTLSGTECLCVCQSGTYGENCE 553
           V+ +PCA  K+  L+ AL+EY  +FDPC C PC N G  T+ GT CLC C+  T+G  CE
Sbjct: 428 VKEVPCASVKKLYLKWALEEYLDEFDPCHCRPCQNGGLATVEGTHCLCHCKPYTFGAACE 487

Query: 554 K-QSPDYKSNAVDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKRCEGEKRQEEDCT 612
           +      ++  VDG W CWSSWS C    K++R+RECNNP P  GG+ C GE  +   C 
Sbjct: 488 QGVLVGNQAGGVDGGWSCWSSWSPC-VQGKKTRSRECNNPPPSGGGRSCVGETTESTQC- 545

Query: 613 FSIMENNGQPCINDDEEMKEVDLPE-------IEADSGCPQPVPPENGFIRNEKQLYLVG 665
                        +DEE++ + L E       +     CP P   ++GF+++E  ++ VG
Sbjct: 546 -------------EDEELEHLRLLEPHCFPLSLVPTEFCPSPPALKDGFVQDEGTMFPVG 592

Query: 666 EDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQRLYRIG 725
           ++V  +C  G+  +G    RC  D  W  G++ CQ+  C+ PV+ + +   P +  Y +G
Sbjct: 593 KNVVYTCNEGYSLIGNPVARCGEDLRWLVGEMHCQKIACVLPVLMDGIQSHPQKPFYTVG 652

Query: 726 ESIELTCPKGFVVAGPSRYTCQGN-SWTPPISNSLTCEKDT-LTKLKGHCQLGQKQSGSE 783
           E + ++C  G  + GPS + C  +  W+P + N+   +K+  LT+    CQ  +K   S 
Sbjct: 653 EKVTVSCSGGMSLEGPSAFLCGSSLKWSPEMKNARCVQKENPLTQAVPKCQRWEKLQNSR 712

Query: 784 CICMSPEEDCSHHSEDLCVFDTDSNDYFTSPACKFLAEKCLNNQQLHFLHIGSCQDGRQL 843
           C+C  P E C   S D+C  D  S        CK           +H LH   CQ     
Sbjct: 713 CVCKMPYE-CG-PSLDVCAQDERSKRILPLTVCK-----------MHVLH---CQGRNYT 756

Query: 844 EWGLERTRLSSNSTKKESCGYDTCYDWEKCSASTSKCVCLLPPQCFKGGNQLYCVKMGSS 903
             G +   L +++ K  +CG   C  W KC A +SKCVC    +C + G  + CV++   
Sbjct: 757 LTGRDSCTLPASAEK--ACG--ACPLWGKCDAESSKCVCREASECEEEGFSI-CVEVNG- 810

Query: 904 TSEKTLNICEVGTIRCANRKMEILHPGKCLA 934
             E+T++ CE G +RC  + + +     C A
Sbjct: 811 -KEQTMSECEAGALRCRGQSISVTSIRPCAA 840



 Score = 33.9 bits (76), Expect = 0.73
 Identities = 18/59 (30%), Positives = 26/59 (44%)

Query: 553 EKQSPDYKSNAVDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKRCEGEKRQEEDC 611
           E QS    S+ V+ QW  ++ WS C+   K    R       Q GG+ C G   + + C
Sbjct: 15  EFQSFSSASSPVNCQWDFYAPWSECNGCTKTQTRRRSVAVYGQYGGQPCVGNAFETQSC 73


>gi|4557389 complement component 8, alpha polypeptide precursor
           [Homo sapiens]
          Length = 584

 Score =  307 bits (787), Expect = 3e-83
 Identities = 183/566 (32%), Positives = 281/566 (49%), Gaps = 52/566 (9%)

Query: 80  INCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAPLVAFQPCIPSKLCKIEEAD 139
           + C L ++  W+DC PC +K+ + RS+L+P++FGG  C+  +     C  S  C + +A 
Sbjct: 37  VTCQLSNWSEWTDCFPCQDKKYRHRSLLQPNKFGGTICSGDIWDQASCSSSTTC-VRQAQ 95

Query: 140 CKNKFRC-DSGRCIARKLECNGENDCGDNSDERDCGRTKAV---CTRKYNPIPSVQLMGN 195
           C   F+C ++GRC+ R L CNG+ DC D SDE DC   +A+   C++ Y PIP  Q    
Sbjct: 96  CGQDFQCKETGRCLKRHLVCNGDQDCLDGSDEDDCEDVRAIDEDCSQ-YEPIPGSQKAAL 154

Query: 196 GFHFLAGEPRGEVLDNSFTGGICKTVKSSR-----------------TSNPYRVPANLEN 238
           G++ L  E    V D S+ GG C+TV +                       +R P N   
Sbjct: 155 GYNILTQEDAQSVYDASYYGGQCETVYNGEWRELRYDSTCERLYYGDDEKYFRKPYNFLK 214

Query: 239 VGFEVQTAEDDLKTDFYKDLTSLGHNENQQGSFSSQGGSSFSVPIFYSSKRSE-----NI 293
             FE   A+  + ++FY +   L     +  S       SF V I      S       +
Sbjct: 215 YHFEA-LADTGISSEFYDNANDLLSKVKKDKS------DSFGVTIGIGPAGSPLLVGVGV 267

Query: 294 NHN--SAFKQAIQASHKKDSSFIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPLEYNS 351
           +H+  ++F   +   ++K   F RI   ++  +F  +  D+ L +  L++L  LP +YN 
Sbjct: 268 SHSQDTSFLNELNKYNEKKFIFTRIFTKVQTAHFKMRKDDIMLDEGMLQSLMELPDQYNY 327

Query: 352 ALYSRIFDDFGTHYFTSGSLGGVYDLLYQFSSEELKNSGLTEEEAKHC----VRIETKKR 407
            +Y++  +D+GTHY TSGS+GG+Y+ +      ++++ G+T  +   C    + I+ + +
Sbjct: 328 GMYAKFINDYGTHYITSGSMGGIYEYILVIDKAKMESLGITSRDITTCFGGSLGIQYEDK 387

Query: 408 VLFAKKTKVEHRCTTNKLSEKHEGSFIQGAEKSISLIRGGRSEYGAALAWEKGSSGLEEK 467
           +        +H C      +          E  IS +RGG S +   LA  + +      
Sbjct: 388 INVGGGLSGDH-CKKFGGGKTERARKAMAVEDIISRVRGGSSGWSGGLAQNRSTI----- 441

Query: 468 TFSEWLESVKENPAVIDFELAPIVDLVRNIPCA--VTKRNNLRKALQEYAAKFDPCQCAP 525
           T+  W  S+K NP VIDFE+ PI +++R+        KR NLR+AL +Y  +F+ C+C P
Sbjct: 442 TYRSWGRSLKYNPVVIDFEMQPIHEVLRHTSLGPLEAKRQNLRRALDQYLMEFNACRCGP 501

Query: 526 CPNNGRPTLSGTECLCVCQSGTYGENCEKQSPDYKSNAVDGQWGCWSSWSTCDATYKRSR 585
           C NNG P L GT C C C+ G+ G  CE+   +      DG W CWSSWS C A   + R
Sbjct: 502 CFNNGVPILEGTSCRCQCRLGSLGAACEQTQTE--GAKADGSWSCWSSWSVCRAGI-QER 558

Query: 586 TRECNNPAPQRGGKRCEGEKRQEEDC 611
            REC+NPAPQ GG  C G K Q + C
Sbjct: 559 RRECDNPAPQNGGASCPGRKVQTQAC 584


>gi|4557391 complement component 8, beta polypeptide preproprotein
           [Homo sapiens]
          Length = 591

 Score =  286 bits (733), Expect = 5e-77
 Identities = 166/561 (29%), Positives = 280/561 (49%), Gaps = 24/561 (4%)

Query: 62  EQICSKQETRECNWQRCPINCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAPL 121
           +     ++ R  +    PI+C L  +  W+ CDPC +K+ +   +L+PSQF G+PC    
Sbjct: 45  KSFAKSRQMRSVDVTLMPIDCELSSWSSWTTCDPCQKKRYRYAYLLQPSQFHGEPCNFSD 104

Query: 122 VAFQPCIPSKLCKIEEADCKNKFRCDSGRCIARKLECNGENDCGDNSDERDCGRTKAVCT 181
              + C+ ++ C   +  C+      +GRC+ R+L CNG+NDCGD SDE +C R    C 
Sbjct: 105 KEVEDCVTNRPCG-SQVRCEGFVCAQTGRCVNRRLLCNGDNDCGDQSDEANCRRIYKKCQ 163

Query: 182 RKYNPIPSVQLMGNGFHFLAGEPRGEVLDNSFTGGICKTVKSSRTSNPYRVPANLENVGF 241
            + +    +  + +G +       G VLD+ +  G C       T   +R P N+E+   
Sbjct: 164 HEMDQYWGIGSLASGINLFTNSFEGPVLDHRYYAGGCSPHYILNTR--FRKPYNVESYTP 221

Query: 242 EVQTAEDDLKTDFYKDLTSLGHNENQQGSFSSQGGSSFSVP-IFYSSKRSENINHNSAFK 300
           + Q   + +  + Y+  +    N  ++ +  S     F +P IF     S++       +
Sbjct: 222 QTQGKYEFILKE-YESYSDFERNVTEKMASKSGFSFGFKIPGIFELGISSQSDRGKHYIR 280

Query: 301 QAIQASHKKDSSFIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPLEYNSALYSRIFDD 360
           +  + SH K S F+     ++V ++  K + L L   FL+ +  LPLEY+   Y  +F D
Sbjct: 281 RTKRFSHTK-SVFLHARSDLEVAHYKLKPRSLMLHYEFLQRVKRLPLEYSYGEYRDLFRD 339

Query: 361 FGTHYFTSGSLGGVYDLLYQFSSEELKNSGLTEEEAKHCVRIETK-----KRVLFAKKTK 415
           FGTHY T   LGG+Y+     + E ++    T      C + + K     + V  +    
Sbjct: 340 FGTHYITEAVLGGIYEYTLVMNKEAMERGDYTLNNVHACAKNDFKIGGAIEEVYVSLGVS 399

Query: 416 V-EHRCTTNKLSEKHEGSFIQGAEKSISLIRGGRSEYGAALAWEKGSSGLEEKTFSEWLE 474
           V + R   N++ ++++   +   E  + L+RGG SE+   LA+++  +        EW +
Sbjct: 400 VGKCRGILNEIKDRNKRDTM--VEDLVVLVRGGASEHITTLAYQELPTA---DLMQEWGD 454

Query: 475 SVKENPAVIDFELAPIVDLV--RNIPCAVTKRNNLRKALQEYAAKFDPCQCAPCPNNGRP 532
           +V+ NPA+I  ++ P+ +LV   +   + T R N+++AL+E+  +   C CAPC  NG P
Sbjct: 455 AVQYNPAIIKVKVEPLYELVTATDFAYSSTVRQNMKQALEEFQKEVSSCHCAPCQGNGVP 514

Query: 533 TLSGTECLCVCQSGTYGENCEKQSPDYKSNA-VDGQWGCWSSWSTCDATYKRSRTRECNN 591
            L G+ C C+C  G+ G  CE     Y+ N  +DG+W CWS+WS+C    +++R R+CNN
Sbjct: 515 VLKGSRCDCICPVGSQGLACE---VSYRKNTPIDGKWNCWSNWSSCSGR-RKTRQRQCNN 570

Query: 592 PAPQRGGKRCEGEKRQEEDCT 612
           P PQ GG  C G   +  DC+
Sbjct: 571 PPPQNGGSPCSGPASETLDCS 591


>gi|4502511 complement component 9 precursor [Homo sapiens]
          Length = 559

 Score =  225 bits (573), Expect = 2e-58
 Identities = 141/514 (27%), Positives = 238/514 (46%), Gaps = 32/514 (6%)

Query: 69  ETRECNWQRCPINCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAPLVAFQPCI 128
           E  E +     I+C +  +  WS CDPC+ +  + RS+    QF G+ CT  +   + C+
Sbjct: 30  ELTESSGSASHIDCRMSPWSEWSQCDPCLRQMFRSRSIEVFGQFNGKRCTDAVGDRRQCV 89

Query: 129 PSKLCKIEEADCKNKFRCDSGRCIARKLECNGENDCGDNSDERDC-GRTKAVC-TRKYNP 186
           P++ C+  E DC N F+C +GRCI  +L CNG+NDCGD SDE DC    +  C  R    
Sbjct: 90  PTEPCEDAEDDCGNDFQCSTGRCIKMRLRCNGDNDCGDFSDEDDCESEPRPPCRDRVVEE 149

Query: 187 IPSVQLMGNGFHFLAGEPRGEVLDNSFTGGICKTVKSSRTSNPYRVPANLENVGFEVQTA 246
               +  G G + L  +P     DN F  G+C   +   T   YR P N+ ++ +E +  
Sbjct: 150 SELARTAGYGINILGMDPLSTPFDNEFYNGLCNRDRDGNTLTYYRRPWNVASLIYETK-G 208

Query: 247 EDDLKTDFYKDLTSLGHNENQQGSFSSQGGSSFSVPIFYSSKRSE--------------- 291
           E + +T+ Y++      +  Q+ + +     S       ++K  +               
Sbjct: 209 EKNFRTEHYEEQIEAFKSIIQEKTSNFNAAISLKFTPTETNKAEQCCEETASSISLHGKG 268

Query: 292 ----NINHNSAFKQAIQASHKKDSSFIRIHKVMKVLNFTTKAKDLHLSDVFLKALNHLPL 347
               + + N  ++  +  S KK+  F+ +   + +  F  + +D+ L+  F+  +  LP 
Sbjct: 269 SFRFSYSKNETYQLFLSYSSKKEKMFLHVKGEIHLGRFVMRNRDVVLTTTFVDDIKALPT 328

Query: 348 EYNSALYSRIFDDFGTHYFTSGSLGGVYDLLYQFSSEELKNSGLTEEEAKHCVRIETKKR 407
            Y    Y    + +GTHY +SGSLGG+Y+L+Y      +K  G+  ++ K C+       
Sbjct: 329 TYEKGEYFAFLETYGTHYSSSGSLGGLYELIYVLDKASMKRKGVELKDIKRCLGYHLDVS 388

Query: 408 VLFAKKTKVEHRCTTNKLSEKHEGSFIQGAEKS-----ISLIRGGRSEYGAALAWEKGSS 462
           + F+ +  V      +   ++ EG  +    ++     +SLIRGG  +Y   L  EK   
Sbjct: 389 LAFS-EISVGAEFNKDDCVKRGEGRAVNITSENLIDDVVSLIRGGTRKYAFELK-EKLLR 446

Query: 463 G--LEEKTFSEWLESVKENPAVIDFELAPIVDLVR-NIPCAVTKRNNLRKALQEYAAKFD 519
           G  ++   F  W  S+ + P +I  +L+PI +LV   +  A  K+ NL +A+++Y  +F 
Sbjct: 447 GTVIDVTDFVNWASSINDAPVLISQKLSPIYNLVPVKMKNAHLKKQNLERAIEDYINEFS 506

Query: 520 PCQCAPCPNNGRPTLSGTECLCVCQSGTYGENCE 553
             +C  C N G   L   +CLC C     G  CE
Sbjct: 507 VRKCHTCQNGGTVILMDGKCLCACPFKFEGIACE 540



 Score = 30.8 bits (68), Expect = 6.2
 Identities = 30/115 (26%), Positives = 42/115 (36%), Gaps = 23/115 (20%)

Query: 564 VDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKRCE---GEKRQ----------EED 610
           +D +   WS WS CD   ++           Q  GKRC    G++RQ          E+D
Sbjct: 41  IDCRMSPWSEWSQCDPCLRQMFRSRSIEVFGQFNGKRCTDAVGDRRQCVPTEPCEDAEDD 100

Query: 611 CTFSIMENNGQPCI---------NDDEEMKEVDLPEIEADSGCPQPVPPENGFIR 656
           C      + G+ CI         ND  +  + D  E E    C   V  E+   R
Sbjct: 101 CGNDFQCSTGR-CIKMRLRCNGDNDCGDFSDEDDCESEPRPPCRDRVVEESELAR 154


>gi|133908621 perforin 1 precursor [Homo sapiens]
          Length = 555

 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 81/299 (27%), Positives = 126/299 (42%), Gaps = 21/299 (7%)

Query: 294 NHNSAFKQAIQASHKKDSSFIRIHKVMKVLNF-TTKAKDLHLSDVFLKALNHLPLEYNSA 352
           +H+ A   A Q +H+   SF       +  +F       LH    F +AL  LP  +N++
Sbjct: 150 SHSQAANFAAQKTHQDQYSFSTDTVECRFYSFHVVHTPPLHPD--FKRALGDLPHHFNAS 207

Query: 353 L---YSRIFDDFGTHYFTSGSLGGVYDLLYQFSSEELKNSGLTEEEAKHCVRIETKKRVL 409
               Y R+  ++GTH+  +  LGG    L    + EL   GLT+ E + C+ +E +  + 
Sbjct: 208 TQPAYLRLISNYGTHFIRAVELGGRISALTALRTCELALEGLTDNEVEDCLTVEAQVNIG 267

Query: 410 FAKKTKVEHR-CTTNKLSEKHEGSFIQGAEKSISLIRGGRSEYGAALAWEKGSSGLEEKT 468
                  E + C   K   K   SF Q   +  S + GG       L +    +G E+  
Sbjct: 268 IHGSISAEAKACEEKKKKHKMTASFHQTYRERHSEVVGGHHTSINDLLFGI-QAGPEQ-- 324

Query: 469 FSEWLESVKENPAVIDFELAPIVDLVRNIPCAVTKRNNLRKALQEY---AAKFDPCQCAP 525
           +S W+ S+  +P ++D+ L P+  L   +     +R  LR+AL +Y    A++  C   P
Sbjct: 325 YSAWVNSLPGSPGLVDYTLEPLHVL---LDSQDPRREALRRALSQYLTDRARWRDCS-RP 380

Query: 526 CPNNGRPTLSGTECLCVCQSG--TYGENCEKQSPDYKSNAVDGQ-WGCWSSWSTCDATY 581
           CP  GR       C CVC     T  + C +Q    +      Q WG W  W T    Y
Sbjct: 381 CP-PGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVTFIQAWGLWGDWFTATDAY 438


>gi|40254808 perforin 1 precursor [Homo sapiens]
          Length = 555

 Score = 86.7 bits (213), Expect = 9e-17
 Identities = 81/299 (27%), Positives = 126/299 (42%), Gaps = 21/299 (7%)

Query: 294 NHNSAFKQAIQASHKKDSSFIRIHKVMKVLNF-TTKAKDLHLSDVFLKALNHLPLEYNSA 352
           +H+ A   A Q +H+   SF       +  +F       LH    F +AL  LP  +N++
Sbjct: 150 SHSQAANFAAQKTHQDQYSFSTDTVECRFYSFHVVHTPPLHPD--FKRALGDLPHHFNAS 207

Query: 353 L---YSRIFDDFGTHYFTSGSLGGVYDLLYQFSSEELKNSGLTEEEAKHCVRIETKKRVL 409
               Y R+  ++GTH+  +  LGG    L    + EL   GLT+ E + C+ +E +  + 
Sbjct: 208 TQPAYLRLISNYGTHFIRAVELGGRISALTALRTCELALEGLTDNEVEDCLTVEAQVNIG 267

Query: 410 FAKKTKVEHR-CTTNKLSEKHEGSFIQGAEKSISLIRGGRSEYGAALAWEKGSSGLEEKT 468
                  E + C   K   K   SF Q   +  S + GG       L +    +G E+  
Sbjct: 268 IHGSISAEAKACEEKKKKHKMTASFHQTYRERHSEVVGGHHTSINDLLFGI-QAGPEQ-- 324

Query: 469 FSEWLESVKENPAVIDFELAPIVDLVRNIPCAVTKRNNLRKALQEY---AAKFDPCQCAP 525
           +S W+ S+  +P ++D+ L P+  L   +     +R  LR+AL +Y    A++  C   P
Sbjct: 325 YSAWVNSLPGSPGLVDYTLEPLHVL---LDSQDPRREALRRALSQYLTDRARWRDCS-RP 380

Query: 526 CPNNGRPTLSGTECLCVCQSG--TYGENCEKQSPDYKSNAVDGQ-WGCWSSWSTCDATY 581
           CP  GR       C CVC     T  + C +Q    +      Q WG W  W T    Y
Sbjct: 381 CP-PGRQKSPRDPCQCVCHGSAVTTQDCCPRQRGLAQLEVTFIQAWGLWGDWFTATDAY 438


>gi|148886654 polydom [Homo sapiens]
          Length = 3571

 Score = 67.4 bits (163), Expect = 6e-11
 Identities = 54/193 (27%), Positives = 82/193 (42%), Gaps = 18/193 (9%)

Query: 644  CPQP-VPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRT 702
            CP P V PEN  + +EK+ Y V ++V I C  GF   G+    C PD TW Q   +C++ 
Sbjct: 3357 CPVPFVIPENALL-SEKEFY-VDQNVSIKCREGFLLQGHGIITCNPDETWTQTSAKCEKI 3414

Query: 703  ECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTC-QGNSWT-PPISNSL- 759
             C  P   E          Y+ G+ I  +C  G+++ G  R  C +  +WT PPI  ++ 
Sbjct: 3415 SCGPPAHVENAIARGVH--YQYGDMITYSCYSGYMLEGFLRSVCLENGTWTSPPICRAVC 3472

Query: 760  --TCEKDTLTKLKGHCQLGQKQSGSEC---ICMSPEEDCSHHSEDLCVFDTDSNDYFTSP 814
               C+   + +    C   +   G  C   IC+ P   C +    +  +  D    +T  
Sbjct: 3473 RFPCQNGGICQRPNACSCPEGWMGRLCEEPICILP---CLNGGRCVAPYQCDCPPGWTGS 3529

Query: 815  AC--KFLAEKCLN 825
             C        CLN
Sbjct: 3530 RCHTAVCQSPCLN 3542



 Score = 67.0 bits (162), Expect = 8e-11
 Identities = 38/121 (31%), Positives = 54/121 (44%), Gaps = 7/121 (5%)

Query: 644  CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTE 703
            C  P  PENG    E  +Y VG +V  SC  G++ +G     CL  G W      C+   
Sbjct: 1789 CKAPGNPENGHSSGE--IYTVGAEVTFSCQEGYQLMGVTKITCLESGEWNHLIPYCKAVS 1846

Query: 704  CIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGN-SW--TPPISNSLT 760
            C KP + E   I   +  +  G  +   C KG+ +AG    +C  N SW  +PP+   + 
Sbjct: 1847 CGKPAIPENGCIE--ELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVK 1904

Query: 761  C 761
            C
Sbjct: 1905 C 1905



 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 39/122 (31%), Positives = 56/122 (45%), Gaps = 7/122 (5%)

Query: 644  CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTE 703
            CPQP    NG I  +   YL       +C  GFE VG     C  +G W  G   C+  E
Sbjct: 2440 CPQPEEIPNGIIDVQGLAYL--STALYTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIE 2497

Query: 704  CIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTC-QGNSW--TPPISNSLT 760
            C+KP  +E+L           G+++  +C +GF + GPS  TC +   W    P  N++ 
Sbjct: 2498 CLKP--KEILNGKFSYTDLHYGQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIH 2555

Query: 761  CE 762
            C+
Sbjct: 2556 CD 2557



 Score = 55.1 bits (131), Expect = 3e-07
 Identities = 35/115 (30%), Positives = 55/115 (47%), Gaps = 7/115 (6%)

Query: 644 CPQPVPPENG-FIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRT 702
           CP   PPENG FI+N    +       + C  GF+ VG     CLP+G W   +  C+  
Sbjct: 378 CPALKPPENGYFIQNTCNNHF-NAACGVRCHPGFDLVGSSIILCLPNGLWSGSESYCRVR 436

Query: 703 EC--IKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGNS-WTPP 754
            C  ++      ++ +  + LY+   +  + C +G+ + G  + TCQGNS W  P
Sbjct: 437 TCPHLRQPKHGHISCSTREMLYK--TTCLVACDEGYRLEGSDKLTCQGNSQWDGP 489



 Score = 52.0 bits (123), Expect = 3e-06
 Identities = 30/104 (28%), Positives = 51/104 (49%), Gaps = 5/104 (4%)

Query: 644  CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTW-RQGDVECQRT 702
            C +P P +NGF++ E   + VG  V+  C  G+E VG   + C   G W ++ + +C   
Sbjct: 2264 CGKPPPIQNGFMKGEN--FEVGSKVQFFCNEGYELVGDSSWTCQKSGKWNKKSNPKCMPA 2321

Query: 703  ECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTC 746
            +C +P + E   +   + L      +  +C +G V+ GPS   C
Sbjct: 2322 KCPEPPLLENQLV--LKELTTEVGVVTFSCKEGHVLQGPSVLKC 2363



 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 57/252 (22%), Positives = 93/252 (36%), Gaps = 48/252 (19%)

Query: 662  YLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQRL 721
            +L G  V  +C  G+E +G     C  DGTW      C   EC  P   E      F R 
Sbjct: 2675 FLYGTMVSYTCNPGYELLGNPVLICQEDGTWNGSAPSCISIECDLPTAPE----NGFLRF 2730

Query: 722  YR--IGESIELTCPKGFVVAGPSRYTCQGN---SWTPPISNSLTCEKDT----------- 765
                +G +++ +C  G ++AG     C  N   S   P   +++C+K             
Sbjct: 2731 TETSMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAISCKKPNPVMNGSIKGSN 2790

Query: 766  ---LTKLKGHCQLGQKQSGSECICMSPEEDCSHHSEDLCVFDTDSNDYFTSPACKFLAEK 822
               L+ L   C  G   +G+E      +++     E +C+   D +    S   +   ++
Sbjct: 2791 YTYLSTLYYECDPGYVLNGTERRTCQDDKNWD-EDEPICI-PVDCSSPPVSANGQVRGDE 2848

Query: 823  CLNNQQLHFLHIGSCQDGRQLEWGLERTRLSSNSTKKESCGYDTCYDWEKCSASTSKCV- 881
                +++ +    +C +G  LE    R  L++ S             W   S +T  CV 
Sbjct: 2849 YTFQKEIEY----TCNEGFLLEGARSRVCLANGS-------------W---SGATPDCVP 2888

Query: 882  --CLLPPQCFKG 891
              C  PPQ   G
Sbjct: 2889 VRCATPPQLANG 2900



 Score = 49.3 bits (116), Expect = 2e-05
 Identities = 31/113 (27%), Positives = 49/113 (43%), Gaps = 5/113 (4%)

Query: 644  CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTE 703
            C +P  PE+GF+   K  Y     +   C  G+E  G +   C  +  W  G   C+ T 
Sbjct: 3241 CGKPESPEHGFVVGSK--YTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETR 3298

Query: 704  CIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGN-SWTPPI 755
            C  P+  E L           G ++  +C +G+ + GPS   C  N +W+ P+
Sbjct: 3299 CETPL--EFLNGKADIENRTTGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPV 3349



 Score = 48.9 bits (115), Expect = 2e-05
 Identities = 31/104 (29%), Positives = 43/104 (41%), Gaps = 4/104 (3%)

Query: 644  CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTE 703
            C  P  PENGF+R  +    +G  V+ SC  G    G     CL +  W      C+   
Sbjct: 2717 CDLPTAPENGFLRFTET--SMGSAVQYSCKPGHILAGSDLRLCLENRKWSGASPRCEAIS 2774

Query: 704  CIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQ 747
            C KP    V+  +     Y    ++   C  G+V+ G  R TCQ
Sbjct: 2775 CKKP--NPVMNGSIKGSNYTYLSTLYYECDPGYVLNGTERRTCQ 2816



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 24/88 (27%), Positives = 37/88 (42%), Gaps = 3/88 (3%)

Query: 668  VEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQRLYRIGES 727
            V  +C  G+   G     CL DG W + D +C    C +P + +  +     RL+  G+ 
Sbjct: 1985 VTYTCKEGYTLAGLDTIECLADGKWSRSDQQCLAVSCDEPPIVDHASPETAHRLF--GDI 2042

Query: 728  IELTCPKGFVVAGPSRYTCQG-NSWTPP 754
                C  G+ +A  S+  C     W PP
Sbjct: 2043 AFYYCSDGYSLADNSQLLCNAQGKWVPP 2070



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 32/120 (26%), Positives = 48/120 (40%), Gaps = 4/120 (3%)

Query: 644  CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTE 703
            CP+P   EN  +   K+L      V  SC  G    G    +CLP   W      C+   
Sbjct: 2323 CPEPPLLENQLVL--KELTTEVGVVTFSCKEGHVLQGPSVLKCLPSQQWNDSFPVCKIVL 2380

Query: 704  CIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQ-GNSWTPPISNSLTCE 762
            C  P +       P   L+  G +++ +C  GF + G S   CQ   +W+ P+   +  E
Sbjct: 2381 CTPPPLISFGVPIPSSALH-FGSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVE 2439



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 24/88 (27%), Positives = 41/88 (46%), Gaps = 3/88 (3%)

Query: 662  YLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQRL 721
            ++ G  ++  C  G++  G    RCL +G+W      C    C  PV+ E  T+      
Sbjct: 2965 FIHGGHIQYQCFPGYKLHGNSSRRCLSNGSWSGSSPSCLPCRCSTPVI-EYGTVNGTD-- 3021

Query: 722  YRIGESIELTCPKGFVVAGPSRYTCQGN 749
            +  G++  + C KGF + G S  TC+ +
Sbjct: 3022 FDCGKAARIQCFKGFKLLGLSEITCEAD 3049



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 36/144 (25%), Positives = 60/144 (41%), Gaps = 19/144 (13%)

Query: 626  DDEEMKEVDLPEIEADSGCPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFR 685
            DD+   E +   I  D  C  P    NG +R ++  Y   +++E +C  GF   G +   
Sbjct: 2817 DDKNWDEDEPICIPVD--CSSPPVSANGQVRGDE--YTFQKEIEYTCNEGFLLEGARSRV 2872

Query: 686  CLPDGTWRQGDVECQRTECIKPV-----VQEVLTITPFQRLYRIGESIELTCPKGFVVAG 740
            CL +G+W     +C    C  P      V E L        Y   + +   C +G+++ G
Sbjct: 2873 CLANGSWSGATPDCVPVRCATPPQLANGVTEGLD-------YGFMKEVTFHCHEGYILHG 2925

Query: 741  PSRYTCQGN-SWTP--PISNSLTC 761
              + TCQ + +W    P+   + C
Sbjct: 2926 APKLTCQSDGNWDAEIPLCKPVNC 2949



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 27/116 (23%), Positives = 46/116 (39%), Gaps = 6/116 (5%)

Query: 644  CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFET-VGYQYFRCLPDGTWRQGDVECQRT 702
            C  P    N     E   Y    +V++ CL G+        F C  DG W    + C   
Sbjct: 3122 CGSPPSVANAVATGEAHTY--ESEVKLRCLEGYTMDTDTDTFTCQKDGRWFPERISCSPK 3179

Query: 703  ECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQ-GNSWTPPISN 757
            +C  P+ + +  I      + +   + ++C +G+   G +   CQ   +W PP S+
Sbjct: 3180 KC--PLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSD 3233



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 32/124 (25%), Positives = 51/124 (41%), Gaps = 7/124 (5%)

Query: 641  DSGCPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQ 700
            ++ C  P+   NG    E +    G +V  SC  G+   G     C  +GTW      C+
Sbjct: 3296 ETRCETPLEFLNGKADIENRT--TGPNVVYSCNRGYSLEGPSEAHCTENGTWSHPVPLCK 3353

Query: 701  RTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQ-GNSWTPPISNSL 759
               C  P V     +   +  Y + +++ + C +GF++ G    TC    +WT     S 
Sbjct: 3354 PNPCPVPFVIPENALLSEKEFY-VDQNVSIKCREGFLLQGHGIITCNPDETWT---QTSA 3409

Query: 760  TCEK 763
             CEK
Sbjct: 3410 KCEK 3413



 Score = 43.9 bits (102), Expect = 7e-04
 Identities = 28/91 (30%), Positives = 35/91 (38%), Gaps = 2/91 (2%)

Query: 665  GEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQRLYRI 724
            G+ V  SC  GF   G     CL  G W      C    C  P   E   +      Y  
Sbjct: 2517 GQTVTYSCNRGFRLEGPSALTCLETGDWDVDAPSCNAIHCDSPQPIENGFVEGAD--YSY 2574

Query: 725  GESIELTCPKGFVVAGPSRYTCQGNSWTPPI 755
            G  I  +C  GF VAG +  TC+ + W+  I
Sbjct: 2575 GAIIIYSCFPGFQVAGHAMQTCEESGWSSSI 2605



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 33/103 (32%), Positives = 45/103 (43%), Gaps = 7/103 (6%)

Query: 665  GEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLT-ITPFQRLYR 723
            G  V+ SC+ GF   G     C PDGTW     EC   EC +P  +E+   I   Q L  
Sbjct: 2401 GSTVKYSCVGGFFLRGNSTTLCQPDGTWSSPLPECVPVECPQP--EEIPNGIIDVQGLAY 2458

Query: 724  IGESIELTCPKGFVVAGPSRYTCQGNS-WT--PPISNSLTCEK 763
            +  ++  TC  GF + G +   C  N  W    P   ++ C K
Sbjct: 2459 LSTAL-YTCKPGFELVGNTTTLCGENGHWLGGKPTCKAIECLK 2500



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 26/101 (25%), Positives = 40/101 (39%), Gaps = 7/101 (6%)

Query: 665  GEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTEC-IKPVVQEVLTITPFQRLYR 723
            G+   I C  GF+ +G     C  DG W  G   C+ T C   P++              
Sbjct: 3025 GKAARIQCFKGFKLLGLSEITCEADGQWSSGFPHCEHTSCGSLPMIPNAFISETSSWKEN 3084

Query: 724  IGESIELTCPKGFVVAGPSRYTC-QGNSWTP--PISNSLTC 761
            +   I  +C  G+V+ G S   C +   W+   P+   L+C
Sbjct: 3085 V---ITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSC 3122



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 28/90 (31%), Positives = 36/90 (40%), Gaps = 7/90 (7%)

Query: 665  GEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQRL--Y 722
            G  V + C  GF+ VG     CL  G W Q    C+R  C  P   E      F     +
Sbjct: 1651 GSKVNLFCDPGFQLVGNPVQYCLNQGQWTQPLPHCERISCGVPPPLE----NGFHSADDF 1706

Query: 723  RIGESIELTCPKGFVVAGPSRYTCQGN-SW 751
              G ++   C  G+ + G SR  C  N SW
Sbjct: 1707 YAGSTVTYQCNNGYYLLGDSRMFCTDNGSW 1736



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 30/123 (24%), Positives = 49/123 (39%), Gaps = 11/123 (8%)

Query: 644  CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTE 703
            C +P  PENG I  E+  +  G  V   C  G+   G +   CL + +W      C+  +
Sbjct: 1847 CGKPAIPENGCI--EELAFTFGSKVTYRCNKGYTLAGDKESSCLANSSWSHSPPVCEPVK 1904

Query: 704  CIKP--VVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGNS-W--TPPISNS 758
            C  P  +      ++    L     +   +C  G+ + GPS   C  +  W   PP  + 
Sbjct: 1905 CSSPENINNGKYILSGLTYL----STASYSCDTGYSLQGPSIIECTASGIWDRAPPACHL 1960

Query: 759  LTC 761
            + C
Sbjct: 1961 VFC 1963



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 24/100 (24%), Positives = 38/100 (38%), Gaps = 5/100 (5%)

Query: 659  KQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQG--DVECQRTECIKPVVQEVLTIT 716
            K  +  G  V   C+ GF         C+  G W      ++C    C +P    ++   
Sbjct: 2099 KAKFAAGSVVSFKCMEGFVLNTSAKIECMRGGQWNPSPMSIQCIPVRCGEP--PSIMNGY 2156

Query: 717  PFQRLYRIGESIELTCPKGFVVAGPSRYTCQG-NSWTPPI 755
                 Y  G  +  +C KGF + G  + TC+    W+ PI
Sbjct: 2157 ASGSNYSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPI 2196



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 36/144 (25%), Positives = 50/144 (34%), Gaps = 8/144 (5%)

Query: 647  PVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQ--GDVECQRTEC 704
            P+P     I      + V   V +SC  G+   G     C  DGTW     D  C    C
Sbjct: 3182 PLPENITHILVHGDDFSVNRQVSVSCAEGYTFEGVNISVCQLDGTWEPPFSDESCSPVSC 3241

Query: 705  IKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGN-SWT--PPISNSLTC 761
             KP   E   +   +  Y    +I   C  G+ + G     CQ N  W+    I     C
Sbjct: 3242 GKPESPEHGFVVGSK--YTFESTIIYQCEPGYELEGNRERVCQENRQWSGGVAICKETRC 3299

Query: 762  EKDTLTKLKGHCQLGQKQSGSECI 785
            E   L  L G   +  + +G   +
Sbjct: 3300 E-TPLEFLNGKADIENRTTGPNVV 3322



 Score = 38.1 bits (87), Expect = 0.039
 Identities = 25/76 (32%), Positives = 31/76 (40%), Gaps = 4/76 (5%)

Query: 632  EVDLPEIEADSGCPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGT 691
            +VD P   A   C  P P ENGF+  E   Y  G  +  SC  GF+  G+    C   G 
Sbjct: 2545 DVDAPSCNAIH-CDSPQPIENGFV--EGADYSYGAIIIYSCFPGFQVAGHAMQTCEESG- 2600

Query: 692  WRQGDVECQRTECIKP 707
            W      C   +C  P
Sbjct: 2601 WSSSIPTCMPIDCGLP 2616



 Score = 37.0 bits (84), Expect = 0.086
 Identities = 26/103 (25%), Positives = 36/103 (34%), Gaps = 4/103 (3%)

Query: 644  CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTE 703
            C  P    NG        YL       SC TG+   G     C   G W +    C    
Sbjct: 1905 CSSPENINNGKYILSGLTYL--STASYSCDTGYSLQGPSIIECTASGIWDRAPPACHLVF 1962

Query: 704  CIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTC 746
            C +P   +   IT     +R   ++  TC +G+ +AG     C
Sbjct: 1963 CGEPPAIKDAVITGNNFTFR--NTVTYTCKEGYTLAGLDTIEC 2003



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 25/97 (25%), Positives = 36/97 (37%), Gaps = 11/97 (11%)

Query: 519  DPCQCAPCPNNGRPTLSGTECLCVCQSGTYGENCEKQSPDYKSNAVDGQWGCWSSWSTCD 578
            D C   PC N            C+C +G  G +CE    + +SN    Q  C    +   
Sbjct: 1347 DECLSQPCKNGATCKDGANSFRCLCAAGFTGSHCELNINECQSNPCRNQATCVDELN--- 1403

Query: 579  ATYKRSRTRECNNPAPQRGGKRCEGEKRQEEDCTFSI 615
                 S + +C    P   GKRCE E+    +  F +
Sbjct: 1404 -----SYSCKCQ---PGFSGKRCETEQSTGFNLDFEV 1432



 Score = 34.3 bits (77), Expect = 0.56
 Identities = 34/125 (27%), Positives = 44/125 (35%), Gaps = 9/125 (7%)

Query: 644  CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTE 703
            C +P    NG+       Y  G  V  SC  GF   G +   C   G W      C    
Sbjct: 2146 CGEPPSIMNGYASGSN--YSFGAMVAYSCNKGFYIKGEKKSTCEATGQWSSPIPTCHPVS 2203

Query: 704  CIKPVVQEVLTITPFQRLYRIGES-IELTCPKGFVVAGPSRYTCQGN----SWTPPISNS 758
            C +P   E   +       RI ES +   C  G+   G   + CQ N    S +P +   
Sbjct: 2204 CGEPPKVENGFLE--HTTGRIFESEVRYQCNPGYKSVGSPVFVCQANRHWHSESPLMCVP 2261

Query: 759  LTCEK 763
            L C K
Sbjct: 2262 LDCGK 2266



 Score = 33.9 bits (76), Expect = 0.73
 Identities = 35/124 (28%), Positives = 47/124 (37%), Gaps = 17/124 (13%)

Query: 519  DPCQCAPCPNNGRPTLSGTECLCVCQSGTYGENCEKQSPDYKSN-------AVDGQWG-- 569
            D C   PC NNG       E +C C SG  G+ CE+   +  S+        VDG  G  
Sbjct: 1233 DECSPLPCLNNGVCKDLVGEFICECPSGYTGQRCEENINECSSSPCLNKGICVDGVAGYR 1292

Query: 570  --CWSSW--STCDATYKRSRTRECNNPA---PQRGGKRCEGEKR-QEEDCTFSIMENNGQ 621
              C   +    C+      ++  C N A    Q GG  C+         C  ++ E   Q
Sbjct: 1293 CTCVKGFVGLHCETEVNECQSNPCLNNAVCEDQVGGFLCKCPPGFLGTRCGKNVDECLSQ 1352

Query: 622  PCIN 625
            PC N
Sbjct: 1353 PCKN 1356



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 20/100 (20%), Positives = 41/100 (41%), Gaps = 3/100 (3%)

Query: 644 CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTE 703
           CP    P++G I    +  L      ++C  G+   G     C  +  W   +  C    
Sbjct: 438 CPHLRQPKHGHISCSTREMLYKTTCLVACDEGYRLEGSDKLTCQGNSQWDGPEPRCVERH 497

Query: 704 CIKPVVQEVLTITPF---QRLYRIGESIELTCPKGFVVAG 740
           C    + + + I+P    ++  + G    ++C +GF+++G
Sbjct: 498 CSTFQMPKDVIISPHNCGKQPAKFGTICYVSCRQGFILSG 537



 Score = 30.4 bits (67), Expect = 8.0
 Identities = 20/88 (22%), Positives = 32/88 (36%), Gaps = 4/88 (4%)

Query: 668  VEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQRLYRIGES 727
            +  SC +G+   G     C   G W Q    C+   C  P    V         +     
Sbjct: 3086 ITYSCRSGYVIQGSSDLICTEKGVWSQPYPVCEPLSCGSP--PSVANAVATGEAHTYESE 3143

Query: 728  IELTCPKGFVV-AGPSRYTCQGNS-WTP 753
            ++L C +G+ +      +TCQ +  W P
Sbjct: 3144 VKLRCLEGYTMDTDTDTFTCQKDGRWFP 3171


>gi|86793109 complement receptor 1 isoform S precursor [Homo sapiens]
          Length = 2489

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 41/162 (25%), Positives = 69/162 (42%), Gaps = 7/162 (4%)

Query: 612  TFSIMENNGQPCINDDEEMKEVDLP----EIEADSGCPQPVPPENG-FIRNEKQLYLVGE 666
            TF+++  +   C +D +       P    E+   + CP P   +NG +I     LYL G 
Sbjct: 2262 TFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGM 2321

Query: 667  DVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPV-VQEVLTITPFQRLYRIG 725
             +   C  G+  VG  +  C   G W Q D  C+   C  P+ +  +      +++Y  G
Sbjct: 2322 TISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEMKKVYHYG 2381

Query: 726  ESIELTCPKGFVVAGPSRYTCQGNS-WTPPISNSLTCEKDTL 766
            + + L C  G+ + G     CQ +  W PP++   +   D L
Sbjct: 2382 DYVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKCTSRTHDAL 2423



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 51/201 (25%), Positives = 80/201 (39%), Gaps = 21/201 (10%)

Query: 583 RSRTRECNNPAPQRGG-----KRCEGEKRQEEDCT--FSIMENNGQPCINDDEEMKEVDL 635
           R R + C NP     G     K  +   + +  CT  + ++ ++   CI   + +   + 
Sbjct: 98  RCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNE 157

Query: 636 PEIEADSGCPQPVPPENG-FIRNEKQLYLVGEDVEISCLTG------FETVGYQYFRCLP 688
             I     C  P    NG FI   ++ +  G  V   C  G      FE VG     C  
Sbjct: 158 TPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTS 217

Query: 689 D----GTWRQGDVECQ-RTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSR 743
           +    G W     +C    +C  P V+  + ++  + L+ + E +E  C  GFV+ GP R
Sbjct: 218 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 277

Query: 744 YTCQG-NSWTPPI-SNSLTCE 762
             CQ  N W P + S S  C+
Sbjct: 278 VKCQALNKWEPELPSCSRVCQ 298



 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 39/133 (29%), Positives = 56/133 (42%), Gaps = 14/133 (10%)

Query: 644 CPQPVPPENG-FIRNEKQLYLVGEDVEISCLTG------FETVGYQYFRCLPD----GTW 692
           C  P    NG FI   ++ +  G  V   C  G      FE VG     C  +    G W
Sbjct: 616 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 675

Query: 693 RQGDVECQ-RTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQG-NS 750
                +C    +C  P V+  + ++  + L+ + E +E  C  GFV+ GP R  CQ  N 
Sbjct: 676 SGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK 735

Query: 751 WTPPI-SNSLTCE 762
           W P + S S  C+
Sbjct: 736 WEPELPSCSRVCQ 748



 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 39/133 (29%), Positives = 56/133 (42%), Gaps = 14/133 (10%)

Query: 644  CPQPVPPENG-FIRNEKQLYLVGEDVEISCLTG------FETVGYQYFRCLPD----GTW 692
            C  P    NG FI   ++ +  G  V   C  G      FE VG     C  +    G W
Sbjct: 1066 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 1125

Query: 693  RQGDVECQ-RTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQG-NS 750
                 +C    +C  P V+  + ++  + L+ + E +E  C  GFV+ GP R  CQ  N 
Sbjct: 1126 SGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK 1185

Query: 751  WTPPI-SNSLTCE 762
            W P + S S  C+
Sbjct: 1186 WEPELPSCSRVCQ 1198



 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 39/133 (29%), Positives = 56/133 (42%), Gaps = 14/133 (10%)

Query: 644  CPQPVPPENG-FIRNEKQLYLVGEDVEISCLTG------FETVGYQYFRCLPD----GTW 692
            C  P    NG FI   ++ +  G  V   C  G      FE VG     C  +    G W
Sbjct: 1516 CGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIW 1575

Query: 693  RQGDVECQ-RTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQG-NS 750
                 +C    +C  P V+  + ++  + L+ + E +E  C  GFV+ GP R  CQ  N 
Sbjct: 1576 SGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK 1635

Query: 751  WTPPI-SNSLTCE 762
            W P + S S  C+
Sbjct: 1636 WEPELPSCSRVCQ 1648



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 38/140 (27%), Positives = 52/140 (37%), Gaps = 13/140 (9%)

Query: 636  PEIEADSGCPQPVPPENGFIRNEKQLYLVGEDVEISCLTG------FETVGYQYFRCLPD 689
            P  E  S  P P      F  N +  +  G  V   C TG      FE VG +   C   
Sbjct: 1962 PICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSK 2021

Query: 690  ----GTWRQGDVECQRT-ECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRY 744
                G W      C  T +C  P V+  + +   +  + + E I   C  GFV+ G    
Sbjct: 2022 DDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTV 2081

Query: 745  TCQGNS-WTPPISN-SLTCE 762
             CQ N  W P + + S  C+
Sbjct: 2082 QCQTNGRWGPKLPHCSRVCQ 2101



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 30/113 (26%), Positives = 47/113 (41%), Gaps = 2/113 (1%)

Query: 636 PEIEADSGCPQPVPPENGFIRNE--KQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWR 693
           PE+ + S   QP P      R +  K  +  G++V  SC  G++  G    RC P G W 
Sbjct: 288 PELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWS 347

Query: 694 QGDVECQRTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTC 746
                C+   C   + Q +     F    ++G  ++  C +GF + G S   C
Sbjct: 348 PAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYC 400



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 30/113 (26%), Positives = 47/113 (41%), Gaps = 2/113 (1%)

Query: 636 PEIEADSGCPQPVPPENGFIRNE--KQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWR 693
           PE+ + S   QP P      R +  K  +  G++V  SC  G++  G    RC P G W 
Sbjct: 738 PELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWS 797

Query: 694 QGDVECQRTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTC 746
                C+   C   + Q +     F    ++G  ++  C +GF + G S   C
Sbjct: 798 PAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYC 850



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 30/113 (26%), Positives = 47/113 (41%), Gaps = 2/113 (1%)

Query: 636  PEIEADSGCPQPVPPENGFIRNE--KQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWR 693
            PE+ + S   QP P      R +  K  +  G++V  SC  G++  G    RC P G W 
Sbjct: 1188 PELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWS 1247

Query: 694  QGDVECQRTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTC 746
                 C+   C   + Q +     F    ++G  ++  C +GF + G S   C
Sbjct: 1248 PAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYC 1300



 Score = 38.9 bits (89), Expect = 0.023
 Identities = 32/137 (23%), Positives = 47/137 (34%), Gaps = 16/137 (11%)

Query: 644 CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGT---WRQGDVECQ 700
           C  P  P NG +     +  VG  +  SC TG   +G+    C+  G    W      CQ
Sbjct: 554 CKTPPDPVNGMVHVITDIQ-VGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 612

Query: 701 RTEC-IKPVVQEVLTITPFQRLYRIGESIELTCPKG------FVVAGPSRYTCQGNS--- 750
           R  C + P +     I+  +  +  G  +   C  G      F + G     C  N    
Sbjct: 613 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQV 672

Query: 751 --WTPPISNSLTCEKDT 765
             W+ P    +   K T
Sbjct: 673 GIWSGPAPQCIIPNKCT 689



 Score = 38.9 bits (89), Expect = 0.023
 Identities = 32/137 (23%), Positives = 47/137 (34%), Gaps = 16/137 (11%)

Query: 644  CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGT---WRQGDVECQ 700
            C  P  P NG +     +  VG  +  SC TG   +G+    C+  G    W      CQ
Sbjct: 1004 CKTPPDPVNGMVHVITDIQ-VGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 1062

Query: 701  RTEC-IKPVVQEVLTITPFQRLYRIGESIELTCPKG------FVVAGPSRYTCQGNS--- 750
            R  C + P +     I+  +  +  G  +   C  G      F + G     C  N    
Sbjct: 1063 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQV 1122

Query: 751  --WTPPISNSLTCEKDT 765
              W+ P    +   K T
Sbjct: 1123 GIWSGPAPQCIIPNKCT 1139



 Score = 38.5 bits (88), Expect = 0.029
 Identities = 32/137 (23%), Positives = 47/137 (34%), Gaps = 16/137 (11%)

Query: 644  CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGT---WRQGDVECQ 700
            C  P  P NG +     +  VG  +  SC TG   +G+    C+  G    W      CQ
Sbjct: 1454 CKTPPDPVNGMVHVITDIQ-VGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQ 1512

Query: 701  RTEC-IKPVVQEVLTITPFQRLYRIGESIELTCPKG------FVVAGPSRYTCQGNS--- 750
            R  C + P +     I+  +  +  G  +   C  G      F + G     C  N    
Sbjct: 1513 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQV 1572

Query: 751  --WTPPISNSLTCEKDT 765
              W+ P    +   K T
Sbjct: 1573 GIWSGPAPQCIIPNKCT 1589



 Score = 38.1 bits (87), Expect = 0.039
 Identities = 29/114 (25%), Positives = 44/114 (38%), Gaps = 4/114 (3%)

Query: 636  PEIEADSGCPQPVPPE---NGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTW 692
            PE+ + S   QP PPE        + +  +  G++V  SC  G++  G     C P G W
Sbjct: 1638 PELPSCSRVCQP-PPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDW 1696

Query: 693  RQGDVECQRTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTC 746
                  C    C   + Q       F    ++G  +   C +GF + G S   C
Sbjct: 1697 SPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHC 1750



 Score = 37.7 bits (86), Expect = 0.050
 Identities = 42/173 (24%), Positives = 68/173 (39%), Gaps = 17/173 (9%)

Query: 615 IMENNGQPCI----NDDEE-MKEVDLPEIEADSGCPQPVPPENGFIRNEKQLYLVGEDVE 669
           + E  G+P I    NDD+  +     P+    + C  P       + + + L+ + E VE
Sbjct: 654 VFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVE 713

Query: 670 ISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQR---LYRIGE 726
             C  GF   G +  +C     W      C R  C  P   +VL     QR    +  G+
Sbjct: 714 FRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPP--PDVLHAERTQRDKDNFSPGQ 770

Query: 727 SIELTCPKGFVVAGPSRYTC--QGNSWTPPISNSLTCEKDTLTKLKGHCQLGQ 777
            +  +C  G+ + G +   C  QG+ W+P    + TCE  +     G    G+
Sbjct: 771 EVFYSCEPGYDLRGAASMRCTPQGD-WSPA---APTCEVKSCDDFMGQLLNGR 819



 Score = 37.7 bits (86), Expect = 0.050
 Identities = 42/173 (24%), Positives = 68/173 (39%), Gaps = 17/173 (9%)

Query: 615  IMENNGQPCI----NDDEE-MKEVDLPEIEADSGCPQPVPPENGFIRNEKQLYLVGEDVE 669
            + E  G+P I    NDD+  +     P+    + C  P       + + + L+ + E VE
Sbjct: 1104 VFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVE 1163

Query: 670  ISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQR---LYRIGE 726
              C  GF   G +  +C     W      C R  C  P   +VL     QR    +  G+
Sbjct: 1164 FRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPP--PDVLHAERTQRDKDNFSPGQ 1220

Query: 727  SIELTCPKGFVVAGPSRYTC--QGNSWTPPISNSLTCEKDTLTKLKGHCQLGQ 777
             +  +C  G+ + G +   C  QG+ W+P    + TCE  +     G    G+
Sbjct: 1221 EVFYSCEPGYDLRGAASMRCTPQGD-WSPA---APTCEVKSCDDFMGQLLNGR 1269



 Score = 37.0 bits (84), Expect = 0.086
 Identities = 33/146 (22%), Positives = 56/146 (38%), Gaps = 8/146 (5%)

Query: 615  IMENNGQPCI----NDDEE-MKEVDLPEIEADSGCPQPVPPENGFIRNEKQLYLVGEDVE 669
            + E  G+P I    NDD+  +     P+    + C  P       + + + L+ + E VE
Sbjct: 1554 VFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVE 1613

Query: 670  ISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQRLYRIGESIE 729
              C  GF   G +  +C     W      C R     P +         Q  +  G+ + 
Sbjct: 1614 FRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVF 1673

Query: 730  LTCPKGFVVAGPSRYTC--QGNSWTP 753
             +C  G+ + G +   C  QG+ W+P
Sbjct: 1674 YSCEPGYDLRGAASLHCTPQGD-WSP 1698



 Score = 33.5 bits (75), Expect = 0.95
 Identities = 28/111 (25%), Positives = 43/111 (38%), Gaps = 20/111 (18%)

Query: 664  VGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQRLYR 723
            VG  +   C  G+    +    CL +  W   +  C+R  C  P         PF  +  
Sbjct: 1868 VGTSLNYECRPGYFGKMFS-ISCLENLVWSSVEDNCRRKSCGPPP-------EPFNGMVH 1919

Query: 724  I------GESIELTCPKGFVVAGPSRYTC--QGNSWT----PPISNSLTCE 762
            I      G ++  +C +GF + G    TC   GN+ T     PI   ++CE
Sbjct: 1920 INTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCE 1970



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 20/83 (24%), Positives = 33/83 (39%), Gaps = 2/83 (2%)

Query: 664 VGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQRLYR 723
           +G  +   C  G+    +    CL +  W      C+R  C  P    V  +    +  +
Sbjct: 65  IGTYLNYECRPGYSGRPFSII-CLKNSVWTGAKDRCRRKSCRNP-PDPVNGMVHVIKGIQ 122

Query: 724 IGESIELTCPKGFVVAGPSRYTC 746
            G  I+ +C KG+ + G S  TC
Sbjct: 123 FGSQIKYSCTKGYRLIGSSSATC 145



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 21/87 (24%), Positives = 32/87 (36%), Gaps = 10/87 (11%)

Query: 665  GEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQRL--- 721
            G++V  SC   ++  G     C P G W      C    C      + L   P  R+   
Sbjct: 2122 GQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSC-----DDFLGQLPHGRVLLP 2176

Query: 722  --YRIGESIELTCPKGFVVAGPSRYTC 746
               ++G  +   C +GF + G S   C
Sbjct: 2177 LNLQLGAKVSFVCDEGFRLKGRSASHC 2203



 Score = 30.8 bits (68), Expect = 6.2
 Identities = 20/67 (29%), Positives = 24/67 (35%), Gaps = 4/67 (5%)

Query: 644  CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDG---TWRQGDVECQ 700
            C  P  P NG +         G  V  SC  GF  +G     CL  G   TW +    C+
Sbjct: 1907 CGPPPEPFNGMVHINTDTQF-GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICE 1965

Query: 701  RTECIKP 707
               C  P
Sbjct: 1966 IISCEPP 1972


>gi|86793036 complement receptor 1 isoform F precursor [Homo sapiens]
          Length = 2039

 Score = 66.6 bits (161), Expect = 1e-10
 Identities = 41/162 (25%), Positives = 69/162 (42%), Gaps = 7/162 (4%)

Query: 612  TFSIMENNGQPCINDDEEMKEVDLP----EIEADSGCPQPVPPENG-FIRNEKQLYLVGE 666
            TF+++  +   C +D +       P    E+   + CP P   +NG +I     LYL G 
Sbjct: 1812 TFNLIGESSIRCTSDPQGNGVWSSPAPRCELSVPAACPHPPKIQNGHYIGGHVSLYLPGM 1871

Query: 667  DVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPV-VQEVLTITPFQRLYRIG 725
             +   C  G+  VG  +  C   G W Q D  C+   C  P+ +  +      +++Y  G
Sbjct: 1872 TISYICDPGYLLVGKGFIFCTDQGIWSQLDHYCKEVNCSFPLFMNGISKELEMKKVYHYG 1931

Query: 726  ESIELTCPKGFVVAGPSRYTCQGNS-WTPPISNSLTCEKDTL 766
            + + L C  G+ + G     CQ +  W PP++   +   D L
Sbjct: 1932 DYVTLKCEDGYTLEGSPWSQCQADDRWDPPLAKCTSRTHDAL 1973



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 51/201 (25%), Positives = 80/201 (39%), Gaps = 21/201 (10%)

Query: 583 RSRTRECNNPAPQRGG-----KRCEGEKRQEEDCT--FSIMENNGQPCINDDEEMKEVDL 635
           R R + C NP     G     K  +   + +  CT  + ++ ++   CI   + +   + 
Sbjct: 98  RCRRKSCRNPPDPVNGMVHVIKGIQFGSQIKYSCTKGYRLIGSSSATCIISGDTVIWDNE 157

Query: 636 PEIEADSGCPQPVPPENG-FIRNEKQLYLVGEDVEISCLTG------FETVGYQYFRCLP 688
             I     C  P    NG FI   ++ +  G  V   C  G      FE VG     C  
Sbjct: 158 TPICDRIPCGLPPTITNGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTS 217

Query: 689 D----GTWRQGDVECQ-RTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSR 743
           +    G W     +C    +C  P V+  + ++  + L+ + E +E  C  GFV+ GP R
Sbjct: 218 NDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRR 277

Query: 744 YTCQG-NSWTPPI-SNSLTCE 762
             CQ  N W P + S S  C+
Sbjct: 278 VKCQALNKWEPELPSCSRVCQ 298



 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 39/133 (29%), Positives = 56/133 (42%), Gaps = 14/133 (10%)

Query: 644 CPQPVPPENG-FIRNEKQLYLVGEDVEISCLTG------FETVGYQYFRCLPD----GTW 692
           C  P    NG FI   ++ +  G  V   C  G      FE VG     C  +    G W
Sbjct: 616 CGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQVGIW 675

Query: 693 RQGDVECQ-RTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQG-NS 750
                +C    +C  P V+  + ++  + L+ + E +E  C  GFV+ GP R  CQ  N 
Sbjct: 676 SGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK 735

Query: 751 WTPPI-SNSLTCE 762
           W P + S S  C+
Sbjct: 736 WEPELPSCSRVCQ 748



 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 39/133 (29%), Positives = 56/133 (42%), Gaps = 14/133 (10%)

Query: 644  CPQPVPPENG-FIRNEKQLYLVGEDVEISCLTG------FETVGYQYFRCLPD----GTW 692
            C  P    NG FI   ++ +  G  V   C  G      FE VG     C  +    G W
Sbjct: 1066 CGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQVGIW 1125

Query: 693  RQGDVECQ-RTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQG-NS 750
                 +C    +C  P V+  + ++  + L+ + E +E  C  GFV+ GP R  CQ  N 
Sbjct: 1126 SGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVEFRCQPGFVMKGPRRVKCQALNK 1185

Query: 751  WTPPI-SNSLTCE 762
            W P + S S  C+
Sbjct: 1186 WEPELPSCSRVCQ 1198



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 38/140 (27%), Positives = 52/140 (37%), Gaps = 13/140 (9%)

Query: 636  PEIEADSGCPQPVPPENGFIRNEKQLYLVGEDVEISCLTG------FETVGYQYFRCLPD 689
            P  E  S  P P      F  N +  +  G  V   C TG      FE VG +   C   
Sbjct: 1512 PICEIISCEPPPTISNGDFYSNNRTSFHNGTVVTYQCHTGPDGEQLFELVGERSIYCTSK 1571

Query: 690  ----GTWRQGDVECQRT-ECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRY 744
                G W      C  T +C  P V+  + +   +  + + E I   C  GFV+ G    
Sbjct: 1572 DDQVGVWSSPPPRCISTNKCTAPEVENAIRVPGNRSFFTLTEIIRFRCQPGFVMVGSHTV 1631

Query: 745  TCQGNS-WTPPISN-SLTCE 762
             CQ N  W P + + S  C+
Sbjct: 1632 QCQTNGRWGPKLPHCSRVCQ 1651



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 30/113 (26%), Positives = 47/113 (41%), Gaps = 2/113 (1%)

Query: 636 PEIEADSGCPQPVPPENGFIRNE--KQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWR 693
           PE+ + S   QP P      R +  K  +  G++V  SC  G++  G    RC P G W 
Sbjct: 288 PELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWS 347

Query: 694 QGDVECQRTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTC 746
                C+   C   + Q +     F    ++G  ++  C +GF + G S   C
Sbjct: 348 PAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYC 400



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 30/113 (26%), Positives = 47/113 (41%), Gaps = 2/113 (1%)

Query: 636 PEIEADSGCPQPVPPENGFIRNE--KQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWR 693
           PE+ + S   QP P      R +  K  +  G++V  SC  G++  G    RC P G W 
Sbjct: 738 PELPSCSRVCQPPPDVLHAERTQRDKDNFSPGQEVFYSCEPGYDLRGAASMRCTPQGDWS 797

Query: 694 QGDVECQRTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTC 746
                C+   C   + Q +     F    ++G  ++  C +GF + G S   C
Sbjct: 798 PAAPTCEVKSCDDFMGQLLNGRVLFPVNLQLGAKVDFVCDEGFQLKGSSASYC 850



 Score = 38.9 bits (89), Expect = 0.023
 Identities = 32/137 (23%), Positives = 47/137 (34%), Gaps = 16/137 (11%)

Query: 644 CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGT---WRQGDVECQ 700
           C  P  P NG +     +  VG  +  SC TG   +G+    C+  G    W      CQ
Sbjct: 554 CKTPPDPVNGMVHVITDIQ-VGSRINYSCTTGHRLIGHSSAECILSGNAAHWSTKPPICQ 612

Query: 701 RTEC-IKPVVQEVLTITPFQRLYRIGESIELTCPKG------FVVAGPSRYTCQGNS--- 750
           R  C + P +     I+  +  +  G  +   C  G      F + G     C  N    
Sbjct: 613 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNPGSGGRKVFELVGEPSIYCTSNDDQV 672

Query: 751 --WTPPISNSLTCEKDT 765
             W+ P    +   K T
Sbjct: 673 GIWSGPAPQCIIPNKCT 689



 Score = 38.5 bits (88), Expect = 0.029
 Identities = 32/137 (23%), Positives = 47/137 (34%), Gaps = 16/137 (11%)

Query: 644  CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGT---WRQGDVECQ 700
            C  P  P NG +     +  VG  +  SC TG   +G+    C+  G    W      CQ
Sbjct: 1004 CKTPPDPVNGMVHVITDIQ-VGSRINYSCTTGHRLIGHSSAECILSGNTAHWSTKPPICQ 1062

Query: 701  RTEC-IKPVVQEVLTITPFQRLYRIGESIELTCPKG------FVVAGPSRYTCQGNS--- 750
            R  C + P +     I+  +  +  G  +   C  G      F + G     C  N    
Sbjct: 1063 RIPCGLPPTIANGDFISTNRENFHYGSVVTYRCNLGSRGRKVFELVGEPSIYCTSNDDQV 1122

Query: 751  --WTPPISNSLTCEKDT 765
              W+ P    +   K T
Sbjct: 1123 GIWSGPAPQCIIPNKCT 1139



 Score = 38.1 bits (87), Expect = 0.039
 Identities = 29/114 (25%), Positives = 44/114 (38%), Gaps = 4/114 (3%)

Query: 636  PEIEADSGCPQPVPPE---NGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTW 692
            PE+ + S   QP PPE        + +  +  G++V  SC  G++  G     C P G W
Sbjct: 1188 PELPSCSRVCQP-PPEILHGEHTPSHQDNFSPGQEVFYSCEPGYDLRGAASLHCTPQGDW 1246

Query: 693  RQGDVECQRTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTC 746
                  C    C   + Q       F    ++G  +   C +GF + G S   C
Sbjct: 1247 SPEAPRCAVKSCDDFLGQLPHGRVLFPLNLQLGAKVSFVCDEGFRLKGSSVSHC 1300



 Score = 37.7 bits (86), Expect = 0.050
 Identities = 42/173 (24%), Positives = 68/173 (39%), Gaps = 17/173 (9%)

Query: 615 IMENNGQPCI----NDDEE-MKEVDLPEIEADSGCPQPVPPENGFIRNEKQLYLVGEDVE 669
           + E  G+P I    NDD+  +     P+    + C  P       + + + L+ + E VE
Sbjct: 654 VFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVE 713

Query: 670 ISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQR---LYRIGE 726
             C  GF   G +  +C     W      C R  C  P   +VL     QR    +  G+
Sbjct: 714 FRCQPGFVMKGPRRVKCQALNKWEPELPSCSRV-CQPP--PDVLHAERTQRDKDNFSPGQ 770

Query: 727 SIELTCPKGFVVAGPSRYTC--QGNSWTPPISNSLTCEKDTLTKLKGHCQLGQ 777
            +  +C  G+ + G +   C  QG+ W+P    + TCE  +     G    G+
Sbjct: 771 EVFYSCEPGYDLRGAASMRCTPQGD-WSPA---APTCEVKSCDDFMGQLLNGR 819



 Score = 37.0 bits (84), Expect = 0.086
 Identities = 33/146 (22%), Positives = 56/146 (38%), Gaps = 8/146 (5%)

Query: 615  IMENNGQPCI----NDDEE-MKEVDLPEIEADSGCPQPVPPENGFIRNEKQLYLVGEDVE 669
            + E  G+P I    NDD+  +     P+    + C  P       + + + L+ + E VE
Sbjct: 1104 VFELVGEPSIYCTSNDDQVGIWSGPAPQCIIPNKCTPPNVENGILVSDNRSLFSLNEVVE 1163

Query: 670  ISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQRLYRIGESIE 729
              C  GF   G +  +C     W      C R     P +         Q  +  G+ + 
Sbjct: 1164 FRCQPGFVMKGPRRVKCQALNKWEPELPSCSRVCQPPPEILHGEHTPSHQDNFSPGQEVF 1223

Query: 730  LTCPKGFVVAGPSRYTC--QGNSWTP 753
             +C  G+ + G +   C  QG+ W+P
Sbjct: 1224 YSCEPGYDLRGAASLHCTPQGD-WSP 1248



 Score = 33.5 bits (75), Expect = 0.95
 Identities = 28/111 (25%), Positives = 43/111 (38%), Gaps = 20/111 (18%)

Query: 664  VGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQRLYR 723
            VG  +   C  G+    +    CL +  W   +  C+R  C  P         PF  +  
Sbjct: 1418 VGTSLNYECRPGYFGKMFS-ISCLENLVWSSVEDNCRRKSCGPPP-------EPFNGMVH 1469

Query: 724  I------GESIELTCPKGFVVAGPSRYTC--QGNSWT----PPISNSLTCE 762
            I      G ++  +C +GF + G    TC   GN+ T     PI   ++CE
Sbjct: 1470 INTDTQFGSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICEIISCE 1520



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 20/83 (24%), Positives = 33/83 (39%), Gaps = 2/83 (2%)

Query: 664 VGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQRLYR 723
           +G  +   C  G+    +    CL +  W      C+R  C  P    V  +    +  +
Sbjct: 65  IGTYLNYECRPGYSGRPFSII-CLKNSVWTGAKDRCRRKSCRNP-PDPVNGMVHVIKGIQ 122

Query: 724 IGESIELTCPKGFVVAGPSRYTC 746
            G  I+ +C KG+ + G S  TC
Sbjct: 123 FGSQIKYSCTKGYRLIGSSSATC 145



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 21/87 (24%), Positives = 32/87 (36%), Gaps = 10/87 (11%)

Query: 665  GEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQRL--- 721
            G++V  SC   ++  G     C P G W      C    C      + L   P  R+   
Sbjct: 1672 GQEVFYSCEPSYDLRGAASLHCTPQGDWSPEAPRCTVKSC-----DDFLGQLPHGRVLLP 1726

Query: 722  --YRIGESIELTCPKGFVVAGPSRYTC 746
               ++G  +   C +GF + G S   C
Sbjct: 1727 LNLQLGAKVSFVCDEGFRLKGRSASHC 1753



 Score = 30.8 bits (68), Expect = 6.2
 Identities = 20/67 (29%), Positives = 24/67 (35%), Gaps = 4/67 (5%)

Query: 644  CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDG---TWRQGDVECQ 700
            C  P  P NG +         G  V  SC  GF  +G     CL  G   TW +    C+
Sbjct: 1457 CGPPPEPFNGMVHINTDTQF-GSTVNYSCNEGFRLIGSPSTTCLVSGNNVTWDKKAPICE 1515

Query: 701  RTECIKP 707
               C  P
Sbjct: 1516 IISCEPP 1522


>gi|209977117 unc-5 homolog D [Homo sapiens]
          Length = 953

 Score = 64.7 bits (156), Expect = 4e-10
 Identities = 30/76 (39%), Positives = 39/76 (51%), Gaps = 7/76 (9%)

Query: 564 VDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKRCEGEKRQEEDCTFSIMENNGQPC 623
           VDG W  WS WS C    +  R REC  P P+ GGK CEG  ++ E+CT  +       C
Sbjct: 307 VDGSWEVWSEWSVCSPECEHLRIRECTAPPPRNGGKFCEGLSQESENCTDGL-------C 359

Query: 624 INDDEEMKEVDLPEIE 639
           I D + + E+    IE
Sbjct: 360 ILDKKPLHEIKPQSIE 375



 Score = 51.6 bits (122), Expect = 3e-06
 Identities = 23/52 (44%), Positives = 28/52 (53%), Gaps = 3/52 (5%)

Query: 564 VDGQWGCWSSWSTCDATYKRS---RTRECNNPAPQRGGKRCEGEKRQEEDCT 612
           V+G W  W+ WS C+    R    R+R C NPAP  GG  CEG   Q+  CT
Sbjct: 251 VNGGWSSWTEWSACNVRCGRGWQKRSRTCTNPAPLNGGAFCEGMSVQKITCT 302



 Score = 38.5 bits (88), Expect = 0.029
 Identities = 35/129 (27%), Positives = 51/129 (39%), Gaps = 23/129 (17%)

Query: 28  AWTQWTSCSKTCNSGTQSRHRQIVVDKYYQEN-FCEQICSKQETRECNWQRCPINCLLGD 86
           +WT+W++C+  C  G Q R R            FCE +  ++ T  C    CP++     
Sbjct: 257 SWTEWSACNVRCGRGWQKRSRTCTNPAPLNGGAFCEGMSVQKIT--CT-SLCPVDGSWEV 313

Query: 87  FGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAPLVAFQPCIPSKLCKIEEADCKNKFRC 146
           +  WS C P  E   ++R            CTAP     P    K C+    + +N   C
Sbjct: 314 WSEWSVCSPECE-HLRIRE-----------CTAP----PPRNGGKFCEGLSQESEN---C 354

Query: 147 DSGRCIARK 155
             G CI  K
Sbjct: 355 TDGLCILDK 363


>gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens]
          Length = 1522

 Score = 63.9 bits (154), Expect = 7e-10
 Identities = 49/174 (28%), Positives = 76/174 (43%), Gaps = 28/174 (16%)

Query: 29  WTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICS--KQETREC-NWQRCPINCLLG 85
           W+QW++CS TC  G+Q R R   V  Y         CS   +E+R C N   CP++ +  
Sbjct: 297 WSQWSTCSVTCGQGSQVRTR-TCVSPYGTH------CSGPLRESRVCNNTALCPVHGVWE 349

Query: 86  DFGPWSDCD-PCIEKQSKVRSVLRPSQFGGQPCTAPLVAFQPCIPSKLCKIE-------- 136
           ++ PWS C   C   Q        P Q+GG+PC  P    +PC    LC ++        
Sbjct: 350 EWSPWSLCSFTCGRGQRTRTRSCTPPQYGGRPCEGPETHHKPC-NIALCPVDGQWQEWSS 408

Query: 137 ----EADCKNKFRCDSGRCIARKLECNGENDC-GDNSDERDCGRTKAVCTRKYN 185
                  C N  +  S +C A     +G ++C G  ++ R+C   +     ++N
Sbjct: 409 WSQCSVTCSNGTQQRSRQCTA---AAHGGSECRGPWAESRECYNPECTANGQWN 459



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 30/87 (34%), Positives = 42/87 (48%), Gaps = 8/87 (9%)

Query: 541 CVCQSGTYGENCEKQSPDYKSNA---VDGQWGCWSSWSTCDATY---KRSRTRECNNPAP 594
           CV   GT+     ++S    + A   V G W  WS WS C  T    +R+RTR C    P
Sbjct: 318 CVSPYGTHCSGPLRESRVCNNTALCPVHGVWEEWSPWSLCSFTCGRGQRTRTRSCT--PP 375

Query: 595 QRGGKRCEGEKRQEEDCTFSIMENNGQ 621
           Q GG+ CEG +   + C  ++   +GQ
Sbjct: 376 QYGGRPCEGPETHHKPCNIALCPVDGQ 402



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 24/61 (39%), Positives = 29/61 (47%), Gaps = 5/61 (8%)

Query: 564 VDGQWGCWSSWSTCDATYK---RSRTRECNNPAPQRGGKRCEGEKRQEEDCTFSIMENNG 620
           VDGQW  WSSWS C  T     + R+R+C   A   GG  C G   +  +C       NG
Sbjct: 399 VDGQWQEWSSWSQCSVTCSNGTQQRSRQCT--AAAHGGSECRGPWAESRECYNPECTANG 456

Query: 621 Q 621
           Q
Sbjct: 457 Q 457



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 23/65 (35%), Positives = 30/65 (46%), Gaps = 3/65 (4%)

Query: 29  WTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETRECNWQRCPINCLLGDFG 88
           W+ W+ CS TC++GTQ R RQ     +      E      E+REC    C  N     +G
Sbjct: 406 WSSWSQCSVTCSNGTQQRSRQCTAAAH---GGSECRGPWAESRECYNPECTANGQWNQWG 462

Query: 89  PWSDC 93
            WS C
Sbjct: 463 HWSGC 467



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 32/116 (27%), Positives = 49/116 (42%), Gaps = 26/116 (22%)

Query: 520 PCQCAPCPNNGR--PTLSGTECLCVCQSGT--------------------YGENCEKQSP 557
           PC  A CP +G+     S ++C   C +GT                    + E+ E  +P
Sbjct: 391 PCNIALCPVDGQWQEWSSWSQCSVTCSNGTQQRSRQCTAAAHGGSECRGPWAESRECYNP 450

Query: 558 DYKSNAVDGQWGCWSSWS-TCDATYKRSRTRECNNPAPQRGGKRCEGEKRQEEDCT 612
           +  +N    QWG WS  S +CD  ++R R R C        G++CEG   +   C+
Sbjct: 451 ECTANGQWNQWGHWSGCSKSCDGGWER-RIRTCQGAVIT--GQQCEGTGEEVRRCS 503



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 21/53 (39%), Positives = 28/53 (52%), Gaps = 7/53 (13%)

Query: 29  WTQWTSCSKTCNSGTQSRHR--QIVVDKYYQENFCEQICSKQETRECNWQRCP 79
           W  W+ CSK+C+ G + R R  Q  V    Q   CE   + +E R C+ QRCP
Sbjct: 461 WGHWSGCSKSCDGGWERRIRTCQGAVITGQQ---CEG--TGEEVRRCSEQRCP 508



 Score = 33.9 bits (76), Expect = 0.73
 Identities = 22/64 (34%), Positives = 29/64 (45%), Gaps = 9/64 (14%)

Query: 553 EKQSPDYKSNAVDGQWGC--WSSWSTCDATY---KRSRTRECNNPAPQRGGKRCEGEKRQ 607
           ++Q+   K  A  G+ G   WS WSTC  T     + RTR C +P     G  C G  R+
Sbjct: 277 QEQADAAKFMAQTGESGVEEWSQWSTCSVTCGQGSQVRTRTCVSPY----GTHCSGPLRE 332

Query: 608 EEDC 611
              C
Sbjct: 333 SRVC 336


>gi|147904700 semaphorin 5A [Homo sapiens]
          Length = 1074

 Score = 63.2 bits (152), Expect = 1e-09
 Identities = 38/99 (38%), Positives = 43/99 (43%), Gaps = 18/99 (18%)

Query: 528 NNGRPTLSGTECLCVCQSGTYGENCEKQSPDYKSNAVDGQWGCWSSWSTCDATYKRS--- 584
           NN  P   G  CL        G + E Q  +     VDG W CWS W+ C AT       
Sbjct: 812 NNPEPKYGGMPCL--------GPSLEYQECNILPCPVDGVWSCWSPWTKCSATCGGGHYM 863

Query: 585 RTRECNNPAPQRGGKRCEGEKRQEEDCTFSIMENNGQPC 623
           RTR C+NPAP  GG  C G   +E  C       N QPC
Sbjct: 864 RTRSCSNPAPAYGGDICLGLHTEEALC-------NTQPC 895



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 29/79 (36%), Positives = 40/79 (50%), Gaps = 10/79 (12%)

Query: 543 CQS-GTYGENCEKQSPD------YKSNAVDGQWGCWSSWSTCDATYKR---SRTRECNNP 592
           C S GT G + +  S D      Y ++ V+G W  W+SWS C     R   +R R CNNP
Sbjct: 755 CSSDGTSGCSTDGLSGDFLRAGRYSAHTVNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNP 814

Query: 593 APQRGGKRCEGEKRQEEDC 611
            P+ GG  C G   + ++C
Sbjct: 815 EPKYGGMPCLGPSLEYQEC 833



 Score = 53.9 bits (128), Expect = 7e-07
 Identities = 24/66 (36%), Positives = 35/66 (53%), Gaps = 3/66 (4%)

Query: 549 GENCEKQSPDYKSNAVDGQWGCWSSWSTCDATYK---RSRTRECNNPAPQRGGKRCEGEK 605
           G  CE    +  + + +G W  W+SWS C  T     + R R C+NP P+ GG+ C G+ 
Sbjct: 579 GWQCEGPGMEIANCSRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQN 638

Query: 606 RQEEDC 611
           R+E  C
Sbjct: 639 REERYC 644



 Score = 49.7 bits (117), Expect = 1e-05
 Identities = 23/55 (41%), Positives = 32/55 (58%), Gaps = 6/55 (10%)

Query: 564 VDGQWGCWSSWSTCDATYKRS------RTRECNNPAPQRGGKRCEGEKRQEEDCT 612
           VDG +G WS W+ C  T   +      RTR C++PAPQ GG +CEG   +  +C+
Sbjct: 539 VDGHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGMEIANCS 593



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 30/116 (25%), Positives = 44/116 (37%), Gaps = 21/116 (18%)

Query: 517 KFDPCQCAPCPNNGRPTLSG--TECLCVCQSGTY--GENCEKQSPDYKSNAVDG------ 566
           ++  C   PCP +G  +     T+C   C  G Y    +C   +P Y  +   G      
Sbjct: 829 EYQECNILPCPVDGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEA 888

Query: 567 ---------QWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKRCEGEKRQEEDCTF 613
                     W  WS WS C+A+  + R R+C    P   G +C G   +   C F
Sbjct: 889 LCNTQPCPESWSEWSDWSECEASGVQVRARQCILLFPM--GSQCSGNTTESRPCVF 942



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 36/156 (23%), Positives = 64/156 (41%), Gaps = 14/156 (8%)

Query: 28  AWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQIC--SKQETRECNWQRCPINCLLG 85
           AWT W+ CS+ C+ G ++R R   V    +  +    C     E +ECN   CP++ +  
Sbjct: 789 AWTSWSQCSRDCSRGIRNRKR---VCNNPEPKYGGMPCLGPSLEYQECNILPCPVDGVWS 845

Query: 86  DFGPWSDCDPCI--EKQSKVRSVLRPS-QFGGQPCTAPLVAFQPCIPSKLCKIEEADCKN 142
            + PW+ C          + RS   P+  +GG  C   L   +    ++ C    ++  +
Sbjct: 846 CWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLG-LHTEEALCNTQPCPESWSEWSD 904

Query: 143 KFRCDSGRCIARKLEC-----NGENDCGDNSDERDC 173
              C++     R  +C      G    G+ ++ R C
Sbjct: 905 WSECEASGVQVRARQCILLFPMGSQCSGNTTESRPC 940



 Score = 37.7 bits (86), Expect = 0.050
 Identities = 22/67 (32%), Positives = 28/67 (41%), Gaps = 4/67 (5%)

Query: 29  WTQWTSCSKTCNSGTQSRHRQIV-VDKYYQENFCEQICSKQETRECNWQ-RCPINCLLGD 86
           WT W+ CS TC  G Q R R        +    C  +   +E R CN    CP +     
Sbjct: 601 WTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVC--VGQNREERYCNEHLLCPPHMFWTG 658

Query: 87  FGPWSDC 93
           +GPW  C
Sbjct: 659 WGPWERC 665



 Score = 32.0 bits (71), Expect = 2.8
 Identities = 42/193 (21%), Positives = 64/193 (33%), Gaps = 35/193 (18%)

Query: 29  WTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETRECNWQRCP------INC 82
           W+ WT C+ T  S   S               C          +C   +C        NC
Sbjct: 546 WSPWTPCTHTDGSAVGS-------------CLCRTRSCDSPAPQCGGWQCEGPGMEIANC 592

Query: 83  LL-GDFGPWSDCDPC-----IEKQSKVRSVLRPS-QFGGQPCTAPLVAFQPCIPSKLCKI 135
              G + PW+   PC     I  Q + RS   P+ + GG+ C       + C    LC  
Sbjct: 593 SRNGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLCPP 652

Query: 136 EEADC------KNKFRCDSGRCIARKLECNGENDCGDNSDERDCGRTKAVCTRK---YNP 186
                      +   +C  G    R++  NG +  G N + + C        +K   + P
Sbjct: 653 HMFWTGWGPWERCTAQCGGGIQARRRICENGPDCAGCNVEYQSCNTNPCPELKKTTPWTP 712

Query: 187 IPSVQLMGNGFHF 199
              V +  NG H+
Sbjct: 713 WTPVNISDNGGHY 725


>gi|42544177 complement component (3d/Epstein Barr virus) receptor 2
           isoform 2 [Homo sapiens]
          Length = 1033

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 63/257 (24%), Positives = 94/257 (36%), Gaps = 30/257 (11%)

Query: 521 CQCAPCPNNGRPT-------LSGTECLCVCQSGTY--GENCEKQSPDYKSNAVDGQWGCW 571
           C   P   NG+ T       L G E    C  G Y  GE   +   D K +      G W
Sbjct: 719 CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGH------GSW 772

Query: 572 SSWSTCDATYKRSRTRECNNPAPQRGGKRCEGEKRQEE------DCTFSIMENNGQP--C 623
           S  S      +      C NP  + G K  +             DC    + N  +   C
Sbjct: 773 SGPSP--QCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRC 830

Query: 624 INDDEEMKEVDLPEIEADSGCPQPVPPENG-FIRNEKQLYLVGEDVEISCLTGFETVGYQ 682
             D+  +  V     +A  GCP P    NG         +  G  +  SC  G+  VG  
Sbjct: 831 HTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEA 890

Query: 683 YFRCLPDGTWRQGDVECQRTECIKPVVQEVLT--ITPFQRLYRIGESIELTCPKGFVVAG 740
              C  +GTW Q    C+   C  P   + +   + P +++Y+ G  + L C  G+++ G
Sbjct: 891 LLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEP-RKMYQYGAVVTLECEDGYMLEG 949

Query: 741 PSRYTCQG-NSWTPPIS 756
             +  CQ  + W PP++
Sbjct: 950 SPQSQCQSDHQWNPPLA 966



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 61/271 (22%), Positives = 91/271 (33%), Gaps = 48/271 (17%)

Query: 550 ENCEKQSPDYKSNAVDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKRCEG------ 603
           E    Q P      + GQ   W+    C+  +       C +P P   G+          
Sbjct: 244 EGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIF-------CPSPPPILNGRHIGNSLANVS 296

Query: 604 ---------EKRQEEDCTFSIMENNGQPCINDDEEMKEVDLPEIEADSG-----CPQPVP 649
                    +   EE   F ++  +   C  D ++      P    +       CP P  
Sbjct: 297 YGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQI 356

Query: 650 PENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVV 709
                +  +K  Y   + V  +C+ GF   G +  RC   GTW      C++ EC  P  
Sbjct: 357 LRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEK-ECQAP-- 413

Query: 710 QEVLTITPFQR---LYRIGESIELTCPKGFVVAGPSRYTCQGNS-WTPPISNS--LTCE- 762
             +L      R    +  G SI+ +C  G+V+ G     C     WTPP+       CE 
Sbjct: 414 PNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEA 473

Query: 763 --KDTLTK---------LKGHCQLGQKQSGS 782
             +  LTK         +   C  G K SGS
Sbjct: 474 TGRQLLTKPQHQFVRPDVNSSCGEGYKLSGS 504



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 66/262 (25%), Positives = 92/262 (35%), Gaps = 29/262 (11%)

Query: 521 CQCAPCPNNGR------PTLSGTECLCVCQSGTYGENCEKQSPDYKSNAVDGQWGCWSSW 574
           C   P   NGR      P   GT     C SGT+    EK       + VDG W      
Sbjct: 23  CGSPPPILNGRISYYSTPIAVGTVIRYSC-SGTFRLIGEKSLLCITKDKVDGTWD--KPA 79

Query: 575 STCDATYKRSRTRECNNPAPQRGGKRCEGEK--RQEEDCTFSIMEN---NGQPCI--NDD 627
             C+   K S   E   P    GG +  G    R  +  TF+   N   NG   +    +
Sbjct: 80  PKCEYFNKYSSCPEPIVP----GGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQAN 135

Query: 628 EEMKEVDLPEIEA--DSGCPQPVPPENGFIRNEKQLYLV-GEDVEISCLTGFETVGYQYF 684
                  LP   +     CP      NG   +E    +  G  V  SC +G+  VG +  
Sbjct: 136 NMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKII 195

Query: 685 RCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRY 744
            CL  G W      C+   C K + +          + R+G +    C +G+ + GP   
Sbjct: 196 NCLSSGKWSAVPPTCEEARC-KSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSS 254

Query: 745 TC----QGNSWTP-PISNSLTC 761
            C    QG +WT  P+   + C
Sbjct: 255 RCVIAGQGVAWTKMPVCEEIFC 276



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 43/184 (23%), Positives = 72/184 (39%), Gaps = 24/184 (13%)

Query: 569 GCWSSWSTCDATYKRSRTRECNNPAPQRGGKRCEGEKRQEEDCTFSIMENNGQPCINDDE 628
           G  +  S  D  Y  + T  CN P P+RG +             FS++  +   C ++D+
Sbjct: 536 GAHTGSSLEDFPYGTTVTYTCN-PGPERGVE-------------FSLIGESTIRCTSNDQ 581

Query: 629 EMKEVDLP----EIEADSGCPQPVPPENGF-IRNEKQLYLVGEDVEISCLTGFETVGYQY 683
           E      P    ++   +     V   NG+ I  ++  Y   + V   C +GF   G   
Sbjct: 582 ERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQ 641

Query: 684 FRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSR 743
            RC  D TW      C++  C + V Q +  +    R+    E +  +C  G+ + G + 
Sbjct: 642 IRCKADNTWDPEIPVCEKETC-QHVRQSLQELPAGSRV----ELVNTSCQDGYQLTGHAY 696

Query: 744 YTCQ 747
             CQ
Sbjct: 697 QMCQ 700


>gi|54792123 complement component (3d/Epstein Barr virus) receptor 2
            isoform 1 [Homo sapiens]
          Length = 1092

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 63/257 (24%), Positives = 94/257 (36%), Gaps = 30/257 (11%)

Query: 521  CQCAPCPNNGRPT-------LSGTECLCVCQSGTY--GENCEKQSPDYKSNAVDGQWGCW 571
            C   P   NG+ T       L G E    C  G Y  GE   +   D K +      G W
Sbjct: 778  CHPPPVIVNGKHTGMMAENFLYGNEVSYECDQGFYLLGEKKLQCRSDSKGH------GSW 831

Query: 572  SSWSTCDATYKRSRTRECNNPAPQRGGKRCEGEKRQEE------DCTFSIMENNGQP--C 623
            S  S      +      C NP  + G K  +             DC    + N  +   C
Sbjct: 832  SGPSP--QCLRSPPVTRCPNPEVKHGYKLNKTHSAYSHNDIVYVDCNPGFIMNGSRVIRC 889

Query: 624  INDDEEMKEVDLPEIEADSGCPQPVPPENG-FIRNEKQLYLVGEDVEISCLTGFETVGYQ 682
              D+  +  V     +A  GCP P    NG         +  G  +  SC  G+  VG  
Sbjct: 890  HTDNTWVPGVPTCIKKAFIGCPPPPKTPNGNHTGGNIARFSPGMSILYSCDQGYLLVGEA 949

Query: 683  YFRCLPDGTWRQGDVECQRTECIKPVVQEVLT--ITPFQRLYRIGESIELTCPKGFVVAG 740
               C  +GTW Q    C+   C  P   + +   + P +++Y+ G  + L C  G+++ G
Sbjct: 950  LLLCTHEGTWSQPAPHCKEVNCSSPADMDGIQKGLEP-RKMYQYGAVVTLECEDGYMLEG 1008

Query: 741  PSRYTCQG-NSWTPPIS 756
              +  CQ  + W PP++
Sbjct: 1009 SPQSQCQSDHQWNPPLA 1025



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 61/271 (22%), Positives = 91/271 (33%), Gaps = 48/271 (17%)

Query: 550 ENCEKQSPDYKSNAVDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKRCEG------ 603
           E    Q P      + GQ   W+    C+  +       C +P P   G+          
Sbjct: 244 EGYRLQGPPSSRCVIAGQGVAWTKMPVCEEIF-------CPSPPPILNGRHIGNSLANVS 296

Query: 604 ---------EKRQEEDCTFSIMENNGQPCINDDEEMKEVDLPEIEADSG-----CPQPVP 649
                    +   EE   F ++  +   C  D ++      P    +       CP P  
Sbjct: 297 YGSIVTYTCDPDPEEGVNFILIGESTLRCTVDSQKTGTWSGPAPRCELSTSAVQCPHPQI 356

Query: 650 PENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTECIKPVV 709
                +  +K  Y   + V  +C+ GF   G +  RC   GTW      C++ EC  P  
Sbjct: 357 LRGRMVSGQKDRYTYNDTVIFACMFGFTLKGSKQIRCNAQGTWEPSAPVCEK-ECQAP-- 413

Query: 710 QEVLTITPFQR---LYRIGESIELTCPKGFVVAGPSRYTCQGNS-WTPPISNS--LTCE- 762
             +L      R    +  G SI+ +C  G+V+ G     C     WTPP+       CE 
Sbjct: 414 PNILNGQKEDRHMVRFDPGTSIKYSCNPGYVLVGEESIQCTSEGVWTPPVPQCKVAACEA 473

Query: 763 --KDTLTK---------LKGHCQLGQKQSGS 782
             +  LTK         +   C  G K SGS
Sbjct: 474 TGRQLLTKPQHQFVRPDVNSSCGEGYKLSGS 504



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 66/262 (25%), Positives = 92/262 (35%), Gaps = 29/262 (11%)

Query: 521 CQCAPCPNNGR------PTLSGTECLCVCQSGTYGENCEKQSPDYKSNAVDGQWGCWSSW 574
           C   P   NGR      P   GT     C SGT+    EK       + VDG W      
Sbjct: 23  CGSPPPILNGRISYYSTPIAVGTVIRYSC-SGTFRLIGEKSLLCITKDKVDGTWD--KPA 79

Query: 575 STCDATYKRSRTRECNNPAPQRGGKRCEGEK--RQEEDCTFSIMEN---NGQPCI--NDD 627
             C+   K S   E   P    GG +  G    R  +  TF+   N   NG   +    +
Sbjct: 80  PKCEYFNKYSSCPEPIVP----GGYKIRGSTPYRHGDSVTFACKTNFSMNGNKSVWCQAN 135

Query: 628 EEMKEVDLPEIEA--DSGCPQPVPPENGFIRNEKQLYLV-GEDVEISCLTGFETVGYQYF 684
                  LP   +     CP      NG   +E    +  G  V  SC +G+  VG +  
Sbjct: 136 NMWGPTRLPTCVSVFPLECPALPMIHNGHHTSENVGSIAPGLSVTYSCESGYLLVGEKII 195

Query: 685 RCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRY 744
            CL  G W      C+   C K + +          + R+G +    C +G+ + GP   
Sbjct: 196 NCLSSGKWSAVPPTCEEARC-KSLGRFPNGKVKEPPILRVGVTANFFCDEGYRLQGPPSS 254

Query: 745 TC----QGNSWTP-PISNSLTC 761
            C    QG +WT  P+   + C
Sbjct: 255 RCVIAGQGVAWTKMPVCEEIFC 276



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 56/260 (21%), Positives = 101/260 (38%), Gaps = 28/260 (10%)

Query: 569 GCWSSWSTCDATYKRSRTRECNNPAPQRGGKRCEGEKRQEEDCTFSIMENNGQPCINDDE 628
           G  +  S  D  Y  + T  CN P P+RG +             FS++  +   C ++D+
Sbjct: 536 GAHTGSSLEDFPYGTTVTYTCN-PGPERGVE-------------FSLIGESTIRCTSNDQ 581

Query: 629 EMKEVDLP----EIEADSGCPQPVPPENGF-IRNEKQLYLVGEDVEISCLTGFETVGYQY 683
           E      P    ++   +     V   NG+ I  ++  Y   + V   C +GF   G   
Sbjct: 582 ERGTWSGPAPLCKLSLLAVQCSHVHIANGYKISGKEAPYFYNDTVTFKCYSGFTLKGSSQ 641

Query: 684 FRCLPDGTWRQGDVECQRTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSR 743
            RC  D TW      C++     P +            +  G +++ TC  G+++ G   
Sbjct: 642 IRCKADNTWDPEIPVCEKGCQSPPGLHHGRHTGGNTVFFVSGMTVDYTCDPGYLLVGNKS 701

Query: 744 YTCQ-GNSWTPPISNSLTCEKDTLTKLKGHCQLGQKQSGSECICMSPEE--DCSHHSEDL 800
             C    +W+P   ++  CE +T   ++   Q     S  E +  S ++    + H+  +
Sbjct: 702 IHCMPSGNWSP---SAPRCE-ETCQHVRQSLQELPAGSRVELVNTSCQDGYQLTGHAYQM 757

Query: 801 CVFDTDSNDYFTS-PACKFL 819
           C  D ++  +F   P CK +
Sbjct: 758 CQ-DAENGIWFKKIPLCKVI 776


>gi|118572606 hemicentin 1 [Homo sapiens]
          Length = 5635

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 32/99 (32%), Positives = 46/99 (46%), Gaps = 18/99 (18%)

Query: 528  NNGRPTLSGTECLCVCQSGTYGENCEKQSPDYKSNAVDGQWGCWSSWSTCDATY---KRS 584
            NN  P   G+ C         G   + Q  + ++  + G+W  W+SWS C  +     R 
Sbjct: 4671 NNPPPAFGGSYC--------DGAETQMQVCNERNCPIHGKWATWASWSACSVSCGGGARQ 4722

Query: 585  RTRECNNPAPQRGGKRCEGEKRQEEDCTFSIMENNGQPC 623
            RTR C++P PQ GG++CEG   Q + C       N  PC
Sbjct: 4723 RTRGCSDPVPQYGGRKCEGSDVQSDFC-------NSDPC 4754



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 35/117 (29%), Positives = 46/117 (39%), Gaps = 24/117 (20%)

Query: 519  DPCQCAPCPNNGR--PTLSGTECLCVCQSGTYGE--NCEKQSPDYKSNA----------- 563
            D C   PCP +G   P      C   C  G       C+   P     A           
Sbjct: 4747 DFCNSDPCPTHGNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQRC 4806

Query: 564  ------VDGQWGCWSSWSTCDATY---KRSRTRECNNPAPQRGGKRCEGEKRQEEDC 611
                  VDG WG W SWS C A+    +++R R C++P P +GG+ C G+  Q   C
Sbjct: 4807 NTDMCPVDGSWGSWHSWSQCSASCGGGEKTRKRLCDHPVPVKGGRPCPGDTTQVTRC 4863



 Score = 53.5 bits (127), Expect = 9e-07
 Identities = 25/58 (43%), Positives = 32/58 (55%), Gaps = 3/58 (5%)

Query: 549  GENCEKQSPDYKSNAVDGQWGCWSSWSTCDATYKR---SRTRECNNPAPQRGGKRCEG 603
            G + E ++   K   VDG W  WS W  C  +  R   +RTR CNNP+ Q GG+ CEG
Sbjct: 4570 GSDLEMRNCQNKPCPVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEG 4627



 Score = 51.2 bits (121), Expect = 4e-06
 Identities = 35/115 (30%), Positives = 46/115 (40%), Gaps = 24/115 (20%)

Query: 521  CQCAPCPNNGRPTLSGT--ECLCVCQSG--TYGENCEKQSPDY-----KSNAVD------ 565
            CQ  PCP +G  +      EC   C  G  T    C   S  +     + NAV+      
Sbjct: 4578 CQNKPCPVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNI 4637

Query: 566  ------GQWGCWSSWSTCDATYKR---SRTRECNNPAPQRGGKRCEGEKRQEEDC 611
                  G W  W  W TC  +  +   +R R CNNP P  GG  C+G + Q + C
Sbjct: 4638 RPCPVHGAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVC 4692



 Score = 47.8 bits (112), Expect = 5e-05
 Identities = 21/58 (36%), Positives = 27/58 (46%), Gaps = 3/58 (5%)

Query: 566  GQWGCWSSWSTCDATY---KRSRTRECNNPAPQRGGKRCEGEKRQEEDCTFSIMENNG 620
            G W  WS W TC  T    +  R R C+NP P  GG+ C G   Q + C   +   +G
Sbjct: 4758 GNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQRCNTDMCPVDG 4815



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 31/105 (29%), Positives = 48/105 (45%), Gaps = 10/105 (9%)

Query: 29   WTQWTSCSKTCNSGTQSRHRQIVVDKYYQENF---CEQICSKQETRECNWQRCPINCLLG 85
            W+ W +CS TC  G Q R R  + ++    N    C+   S  E R C  + CP++    
Sbjct: 4535 WSAWRACSVTCGKGIQKRSR--LCNQPLPANGGKPCQG--SDLEMRNCQNKPCPVDGSWS 4590

Query: 86   DFGPWSDCDPCIEK--QSKVRSVLRPS-QFGGQPCTAPLVAFQPC 127
            ++  W +C     +  Q++ R+   PS Q GG+PC    V    C
Sbjct: 4591 EWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMC 4635



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 29/104 (27%), Positives = 40/104 (38%), Gaps = 8/104 (7%)

Query: 29   WTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICS--KQETRECNWQRCPINCLLGD 86
            W+ W +CS+TCN G   R+R    D     N   + C     + + CN   CP++   G 
Sbjct: 4763 WSGWGTCSRTCNGGQMRRYR--TCDNPPPSN-GGRACGGPDSQIQRCNTDMCPVDGSWGS 4819

Query: 87   FGPWSDCDPCIEKQSKVRSVLRPSQF---GGQPCTAPLVAFQPC 127
            +  WS C        K R  L        GG+PC         C
Sbjct: 4820 WHSWSQCSASCGGGEKTRKRLCDHPVPVKGGRPCPGDTTQVTRC 4863



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 19/51 (37%), Positives = 26/51 (50%), Gaps = 3/51 (5%)

Query: 564  VDGQWGCWSSWSTCDATYKRS---RTRECNNPAPQRGGKRCEGEKRQEEDC 611
            V G +  WS+W  C  T  +    R+R CN P P  GGK C+G   +  +C
Sbjct: 4528 VHGGFSQWSAWRACSVTCGKGIQKRSRLCNQPLPANGGKPCQGSDLEMRNC 4578



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 28/103 (27%), Positives = 41/103 (39%), Gaps = 6/103 (5%)

Query: 29   WTQWTSCSKTCNSGTQSRHRQIVVDKYYQENF-CEQICSKQETRECNWQRCPINCLLGDF 87
            W+ W  C+++C  G Q+R R             CE   +  E   CN + CP++     +
Sbjct: 4592 WSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEG--NAVEIIMCNIRPCPVHGAWSAW 4649

Query: 88   GPWSDCDPCIEKQSKVRSVL---RPSQFGGQPCTAPLVAFQPC 127
             PW  C     K ++ R+ L    P  FGG  C       Q C
Sbjct: 4650 QPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVC 4692



 Score = 44.3 bits (103), Expect = 5e-04
 Identities = 29/95 (30%), Positives = 42/95 (44%), Gaps = 8/95 (8%)

Query: 28   AWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQET--RECNWQRCPINCLLG 85
            AW  W +CS++C  GTQ+R R   +       F    C   ET  + CN + CPI+    
Sbjct: 4648 AWQPWGTCSESCGKGTQTRAR---LCNNPPPAFGGSYCDGAETQMQVCNERNCPIHGKWA 4704

Query: 86   DFGPWSDCDPCI--EKQSKVRSVLRP-SQFGGQPC 117
             +  WS C        + + R    P  Q+GG+ C
Sbjct: 4705 TWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKC 4739


>gi|40317628 thrombospondin 2 precursor [Homo sapiens]
          Length = 1172

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 41/140 (29%), Positives = 56/140 (40%), Gaps = 23/140 (16%)

Query: 495 RNIPCAVTKRNNLRKALQEYAAKFDPCQCAPCPNNGRPTLSG-TECLCVCQSGTY----- 548
           R   C VT    L  ++Q  A     C      + G    S  + C   C  G       
Sbjct: 404 RGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRL 463

Query: 549 ---------GENCEKQSPDYKSNA-----VDGQWGCWSSWSTCDATYK---RSRTRECNN 591
                    G+NC+    + K+       +DG+W  WS WS C  T     R RTR CN+
Sbjct: 464 CNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCNS 523

Query: 592 PAPQRGGKRCEGEKRQEEDC 611
           P PQ GGK C G+ ++ + C
Sbjct: 524 PEPQYGGKACVGDVQERQMC 543



 Score = 61.2 bits (147), Expect = 4e-09
 Identities = 38/113 (33%), Positives = 49/113 (43%), Gaps = 28/113 (24%)

Query: 532 PTLSGTECLCVCQSGTY--GENCEKQS-----PDYKSNAV-----------DGQWGCWSS 573
           P    T+C   C SGT   G +C+  S     P  ++ A            DG W  WS 
Sbjct: 386 PWAEWTQCSVTCGSGTQQRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSP 445

Query: 574 WSTCDATY---KRSRTRECNNPAPQRGGKRCEGEKRQEEDCTFSIMENNGQPC 623
           WS+C  T      +R R CN+P PQ GGK C+G  R+ + C        G PC
Sbjct: 446 WSSCSVTCGVGNITRIRLCNSPVPQMGGKNCKGSGRETKAC-------QGAPC 491



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 51/192 (26%), Positives = 80/192 (41%), Gaps = 24/192 (12%)

Query: 29  WTQWTSCSKTCNSGTQSRHR--QIVVDKYYQENFCEQICSKQETRECNWQRCPINCLLGD 86
           W+ W+SCS TC  G  +R R     V +   +N C+   S +ET+ C    CPI+     
Sbjct: 443 WSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKN-CKG--SGRETKACQGAPCPIDGRWSP 499

Query: 87  FGPWSDCDPC----IEKQSKVRSVLRPSQFGGQPCTAPLVAFQPCIPSKLCKIE------ 136
           + PWS C       I ++++V +   P Q+GG+ C   +   Q C   + C ++      
Sbjct: 500 WSPWSACTVTCAGGIRERTRVCNSPEP-QYGGKACVGDVQERQMC-NKRSCPVDGCLSNP 557

Query: 137 ---EADCKNKFRCDSGRCIARKLECNGENDCGDNSDERDCGRTKAVCTRKYNPIPSVQLM 193
               A C + F   S  C +  +   G     ++ DE  C     +C    + +P     
Sbjct: 558 CFPGAQC-SSFPDGSWSCGSCPVGFLGNGTHCEDLDE--CALVPDICF-STSKVPRCVNT 613

Query: 194 GNGFHFLAGEPR 205
             GFH L   PR
Sbjct: 614 QPGFHCLPCPPR 625



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 30/96 (31%), Positives = 41/96 (42%), Gaps = 13/96 (13%)

Query: 29  WTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETRECNWQRCPINCL----L 84
           W +WT CS TC SGTQ R R   V      N C  +    +TR C+  +C          
Sbjct: 387 WAEWTQCSVTCGSGTQQRGRSCDV----TSNTC--LGPSIQTRACSLSKCDTRIRQDGGW 440

Query: 85  GDFGPWSDCDPC--IEKQSKVRSVLRP-SQFGGQPC 117
             + PWS C     +   +++R    P  Q GG+ C
Sbjct: 441 SHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGGKNC 476


>gi|150170672 thrombospondin, type I, domain containing 7A [Homo
            sapiens]
          Length = 1657

 Score = 61.6 bits (148), Expect = 3e-09
 Identities = 45/163 (27%), Positives = 70/163 (42%), Gaps = 33/163 (20%)

Query: 17   NKGQACFCDHYAWTQWTSCSKT----CNSGTQSRHRQIVVD--KYYQENFCEQICSKQET 70
            N  + C+   Y  T W++C  +    C +G ++R    V    K     +CE +      
Sbjct: 1214 NLNKNCYHYDYNVTDWSTCQLSEKAVCGNGIKTRMLDCVRSDGKSVDLKYCEAL-----G 1268

Query: 71   RECNWQ-------RCPINCLLGDFGPWSDCDPCIEKQSKV---RSVLRPSQFGGQPCTAP 120
             E NWQ        CP+NC L D+ PWS+C        K+   R+V +P Q  G+PC + 
Sbjct: 1269 LEKNWQMNTSCMVECPVNCQLSDWSPWSECSQTCGLTGKMIRRRTVTQPFQGDGRPCPSL 1328

Query: 121  LVAFQPCIPSK-----------LCKIEEADCKNKFRCDSGRCI 152
            +   +PC P K            C+++EA C    R  +  C+
Sbjct: 1329 MDQSKPC-PVKPCYRWQYGQWSPCQVQEAQCGEGTRTRNISCV 1370



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 40/150 (26%), Positives = 61/150 (40%), Gaps = 31/150 (20%)

Query: 29  WTQWTSCSKTCNSG-----TQSRHRQIV----------VDKYYQENFCE--QICSKQETR 71
           ++ WTSC  +C  G      QSRHR I+           D  Y+E  CE  Q C     +
Sbjct: 777 YSDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQSYRWK 836

Query: 72  ECNWQRC---PINCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAPLVAFQPCI 128
              W+RC   P +      G    C P      + R++    Q GGQ      + +   +
Sbjct: 837 THKWRRCQLVPWSVQQDSPGAQEGCGP----GRQARAITCRKQDGGQAGIHECLQYAGPV 892

Query: 129 P--SKLCKIE-EADCK----NKFRCDSGRC 151
           P  ++ C+I  + DC+    +KF   +G C
Sbjct: 893 PALTQACQIPCQDDCQLTSWSKFSSCNGDC 922



 Score = 43.5 bits (101), Expect = 0.001
 Identities = 34/128 (26%), Positives = 57/128 (44%), Gaps = 20/128 (15%)

Query: 24   CDHYAWTQ--WTSCSKT-------CNSGTQSRHRQIVVDKYY--QENFCEQICSKQE--- 69
            C+ Y W    W+ C  T       C  G Q+R  + + +      E+  + +C  +E   
Sbjct: 1094 CNQYLWVTEPWSICKVTFVNMRENCGEGVQTRKVRCMQNTADGPSEHVEDYLCDPEEMPL 1153

Query: 70   -TRECNWQRCPINCLLGDFGPWSDCD-PCIEKQSKVRSV--LRPSQFGGQPCTAPLVAFQ 125
             +R C    CP +C++ ++GPW+ C  PC +   + RS   +R     G+ C    V  +
Sbjct: 1154 GSRVCKLP-CPEDCVISEWGPWTQCVLPCNQSSFRQRSADPIRQPADEGRSC-PNAVEKE 1211

Query: 126  PCIPSKLC 133
            PC  +K C
Sbjct: 1212 PCNLNKNC 1219



 Score = 42.0 bits (97), Expect = 0.003
 Identities = 26/83 (31%), Positives = 37/83 (44%), Gaps = 4/83 (4%)

Query: 57  QENFCEQICSKQETRECNWQRCPINCLLGDFGPWSDCDPCIEK--QSKVRSVLRPSQFGG 114
           ++  CE    K    +     C  +C++ +F  WS+C        Q + R V+ P QFGG
Sbjct: 170 EDIICEYFEPKPLLEQACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGG 229

Query: 115 QPCTAPLVAFQPCIPSKLCKIEE 137
             C   L  FQ C  S  C+ EE
Sbjct: 230 SGC-PNLTEFQVC-QSSPCEAEE 250



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 26/82 (31%), Positives = 34/82 (41%), Gaps = 11/82 (13%)

Query: 20  QACF------CDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETREC 73
           QAC       C    ++ W+ CSKTC SG Q R R +V    +  + C  +    E + C
Sbjct: 185 QACLIPCQQDCIVSEFSAWSECSKTCGSGLQHRTRHVVAPPQFGGSGCPNL---TEFQVC 241

Query: 74  NWQRCPINCLLGDF--GPWSDC 93
               C    L      GPWS C
Sbjct: 242 QSSPCEAEELRYSLHVGPWSTC 263



 Score = 40.0 bits (92), Expect = 0.010
 Identities = 24/75 (32%), Positives = 31/75 (41%), Gaps = 7/75 (9%)

Query: 24  CDHYAWTQWTSCSKTCN----SGTQSRHRQIVVDKYYQENF-CEQICSKQETRECNWQRC 78
           C    W+ W+SCS TC+     G Q R R I+     +    C    + QE R CN   C
Sbjct: 635 CVLSTWSTWSSCSHTCSGKTTEGKQIRARSILAYAGEEGGIRCPNSSALQEVRSCNEHPC 694

Query: 79  PINCLLGDFGPWSDC 93
            +       GPW  C
Sbjct: 695 TV--YHWQTGPWGQC 707



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 38/150 (25%), Positives = 53/150 (35%), Gaps = 29/150 (19%)

Query: 24   CDHYAWTQWTSCS---KTCNSGTQSRHRQIVVD--------KYYQENFCEQI------CS 66
            C  + + QW+ C      C  GT++R+   VV         K   E FC  I        
Sbjct: 1340 CYRWQYGQWSPCQVQEAQCGEGTRTRNISCVVSDGSADDFSKVVDEEFCADIELIIDGNK 1399

Query: 67   KQETRECNWQRCPINCLLGDFGPWSDCD-PCIEKQSKVRSVLRPSQFGGQPCTAPLVAFQ 125
                 E   Q CP +C L D+  WS C   C+  +           FGG    +  V  Q
Sbjct: 1400 NMVLEESCSQPCPGDCYLKDWSSWSLCQLTCVNGED--------LGFGGIQVRSRPVIIQ 1451

Query: 126  PCIPSKLCKIEEADCKNKFRCDSGRCIARK 155
                  LC  +  + K+   C  G+C   K
Sbjct: 1452 ELENQHLCPEQMLETKS---CYDGQCYEYK 1478



 Score = 38.5 bits (88), Expect = 0.029
 Identities = 29/114 (25%), Positives = 47/114 (41%), Gaps = 11/114 (9%)

Query: 30  TQWTSCSKTCNSGTQSRHRQIVVDKYYQ--ENFCEQICSKQETRECNWQRCPINCLLGDF 87
           T W     +C+ G Q+R    V     Q     C +    +  R C    C  +C++  +
Sbjct: 720 TTWNG-EASCSVGMQTRKVICVRVNVGQVGPKKCPESLRPETVRPCLLP-CKKDCIVTPY 777

Query: 88  GPWSDC-------DPCIEKQSKVRSVLRPSQFGGQPCTAPLVAFQPCIPSKLCK 134
             W+ C       D  I KQS+ R +++    GG+ CT PL   + C   + C+
Sbjct: 778 SDWTSCPSSCKEGDSSIRKQSRHRVIIQLPANGGRDCTDPLYEEKACEAPQACQ 831



 Score = 35.0 bits (79), Expect = 0.33
 Identities = 19/72 (26%), Positives = 30/72 (41%), Gaps = 2/72 (2%)

Query: 24   CDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETRECNWQRCPINC- 82
            C    W+ W+ CSK+C SG + R + +    Y     C ++    + +      C  +C 
Sbjct: 1036 CKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPCHSDCN 1095

Query: 83   -LLGDFGPWSDC 93
              L    PWS C
Sbjct: 1096 QYLWVTEPWSIC 1107



 Score = 34.7 bits (78), Expect = 0.43
 Identities = 24/88 (27%), Positives = 36/88 (40%), Gaps = 7/88 (7%)

Query: 24  CDHYAWTQWTSCSKTCN-----SGTQSRHRQIVVDKYYQENFCEQICSKQETRECNWQRC 78
           C    W++W+ CSKTC+     +GT+ R R I       E  C +   K+          
Sbjct: 361 CQVSEWSEWSPCSKTCHDMVSPAGTRVRTRTIRQFPIGSEKECPEFEEKEPCLSQGDGVV 420

Query: 79  PINCLLGDFGPWSDC--DPCIEKQSKVR 104
           P          W++C  DP + +Q K R
Sbjct: 421 PCATYGWRTTEWTECRVDPLLSQQDKRR 448



 Score = 32.3 bits (72), Expect = 2.1
 Identities = 27/103 (26%), Positives = 37/103 (35%), Gaps = 18/103 (17%)

Query: 78   CPINCLLGDFGPWSDCDPCIEKQSKVRSV-LRPSQF-GGQPC-------TAPLVAFQPCI 128
            CP +C L ++  WS C        KVRS  LR   + GG+PC        A +    PC 
Sbjct: 1032 CPSDCKLSEWSNWSRCSKSCGSGVKVRSKWLREKPYNGGRPCPKLDHVNQAQVYEVVPC- 1090

Query: 129  PSKLCKIEEADCKNKFRCDSGRCIARKLECNGENDCGDNSDER 171
                     +DC           I +    N   +CG+    R
Sbjct: 1091 --------HSDCNQYLWVTEPWSICKVTFVNMRENCGEGVQTR 1125


>gi|16933525 unc5C [Homo sapiens]
          Length = 931

 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 25/49 (51%), Positives = 30/49 (61%)

Query: 564 VDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKRCEGEKRQEEDCT 612
           VDG+W  WS WSTC       R REC  PAP+ GGK C+G   Q ++CT
Sbjct: 315 VDGRWTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCT 363



 Score = 54.7 bits (130), Expect = 4e-07
 Identities = 24/52 (46%), Positives = 30/52 (57%), Gaps = 3/52 (5%)

Query: 564 VDGQWGCWSSWSTCDATYKRS---RTRECNNPAPQRGGKRCEGEKRQEEDCT 612
           V+G W  W+ WS C++   R    RTR C NPAP  GG  CEG+  Q+  CT
Sbjct: 259 VNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACT 310



 Score = 31.2 bits (69), Expect = 4.7
 Identities = 23/101 (22%), Positives = 38/101 (37%), Gaps = 6/101 (5%)

Query: 29  WTQWTSCSKTCNSGTQSRHRQIVVDKYYQEN-FCEQICSKQETRECNWQRCPINCLLGDF 87
           WT+W+ C+  C  G Q R R            FCE    +   +      CP++     +
Sbjct: 266 WTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCE---GQSVQKIACTTLCPVDGRWTPW 322

Query: 88  GPWSDC-DPCIEKQSKVRSVLRPSQFGGQPCTAPLVAFQPC 127
             WS C   C   + +  +   P   GG+ C   ++  + C
Sbjct: 323 SKWSTCGTECTHWRRRECTAPAPKN-GGKDCDGLVLQSKNC 362


>gi|4502503 complement component 4 binding protein, alpha chain
           precursor [Homo sapiens]
          Length = 597

 Score = 60.5 bits (145), Expect = 7e-09
 Identities = 38/124 (30%), Positives = 52/124 (41%), Gaps = 6/124 (4%)

Query: 635 LPEIEADSGCPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPD----G 690
           LP+ E    C  P    NG    E+  Y  G  V  SC   F  +G+    C  +    G
Sbjct: 167 LPQCEIVK-CKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIG 225

Query: 691 TWRQGDVECQRTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGNS 750
            WR     C++  C KP V     ++ F  +Y   ++I   C KGFV+ G S   C  +S
Sbjct: 226 VWRPSPPTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADS 285

Query: 751 -WTP 753
            W P
Sbjct: 286 KWNP 289



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 41/192 (21%), Positives = 68/192 (35%), Gaps = 13/192 (6%)

Query: 644 CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGT---WRQGDVECQ 700
           C  P    NG +  +  L   G  +E SC  GF  +G    RC        W     +C+
Sbjct: 113 CRHPGELRNGQVEIKTDLSF-GSQIEFSCSEGFFLIGSTTSRCEVQDRGVGWSHPLPQCE 171

Query: 701 RTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGNSWT-------P 753
             +C  P        +  +  Y  G S+  +C   F + G +  +C   + T       P
Sbjct: 172 IVKCKPPPDIRNGRHSGEENFYAYGFSVTYSCDPRFSLLGHASISCTVENETIGVWRPSP 231

Query: 754 PISNSLTCEKDTLTKLKGHCQLGQKQSGSECICMSPEEDCSHHSEDLCVFDTDSNDYFTS 813
           P    +TC K  ++  +     G   +  + I    ++        +   D DS    + 
Sbjct: 232 PTCEKITCRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSP 291

Query: 814 PACKFLAEKCLN 825
           PAC+     C+N
Sbjct: 292 PACE--PNSCIN 301



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 33/124 (26%), Positives = 50/124 (40%), Gaps = 9/124 (7%)

Query: 644 CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTE 703
           C  P    +G  +         E++   C  G+  VG     C     W     +C+   
Sbjct: 426 CNFPPKIAHGHYKQSSSYSFFKEEIIYECDKGYILVGQAKLSC-SYSHWSAPAPQCKAL- 483

Query: 704 CIKP-VVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGN-SWTPPISNSLTC 761
           C KP +V   L++   Q  Y   E++ + C  G+ V GP   TC GN +W P +     C
Sbjct: 484 CRKPELVNGRLSVDKDQ--YVEPENVTIQCDSGYGVVGPQSITCSGNRTWYPEVPK---C 538

Query: 762 EKDT 765
           E +T
Sbjct: 539 EWET 542



 Score = 33.9 bits (76), Expect = 0.73
 Identities = 26/118 (22%), Positives = 39/118 (33%), Gaps = 8/118 (6%)

Query: 644 CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTE 703
           C +P       +     +Y   + +   C  GF   G     C  D  W      C+   
Sbjct: 239 CRKPDVSHGEMVSGFGPIYNYKDTIVFKCQKGFVLRGSSVIHCDADSKWNPSPPACEPNS 298

Query: 704 CIK-PVVQ----EVLTITPFQRLYRIGESIELTCPKGF--VVAGPSRYTCQGN-SWTP 753
           CI  P +     E       + +Y +G  +   C  G+      P+   CQ N  WTP
Sbjct: 299 CINLPDIPHASWETYPRPTKEDVYVVGTVLRYRCHPGYKPTTDEPTTVICQKNLRWTP 356


>gi|111118994 brain-specific angiogenesis inhibitor 1 precursor
           [Homo sapiens]
          Length = 1584

 Score = 59.7 bits (143), Expect = 1e-08
 Identities = 52/163 (31%), Positives = 70/163 (42%), Gaps = 26/163 (15%)

Query: 29  WTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICS--KQETRECNWQR-CPINCLLG 85
           W+ W+ CS TC  G Q+R R  V   Y  +      CS   +E R CN    CP++    
Sbjct: 360 WSPWSVCSSTCGEGWQTRTRFCVSSSYSTQ------CSGPLREQRLCNNSAVCPVHGAWD 413

Query: 86  DFGPWSDCDPCIEKQSKVRS-VLRPSQFGGQPCTAPLVAFQPCIPSKLCKIEEADCK-NK 143
           ++ PWS C     +  + R+   RP QFGG PC  P    + C    LC     D   N+
Sbjct: 414 EWSPWSLCSSTCGRGFRDRTRTCRPPQFGGNPCEGPEKQTKFC-NIALCPGRAVDGNWNE 472

Query: 144 F--------RCDSGRCIARKLECNGEN----DC-GDNSDERDC 173
           +         C  GR   R  ECNG +    +C G   + RDC
Sbjct: 473 WSSWSACSASCSQGR-QQRTRECNGPSYGGAECQGHWVETRDC 514



 Score = 54.3 bits (129), Expect = 5e-07
 Identities = 31/81 (38%), Positives = 39/81 (48%), Gaps = 14/81 (17%)

Query: 543 CQSGTYGEN-CEKQSPDYK--------SNAVDGQWGCWSSWSTCDATY---KRSRTRECN 590
           C+   +G N CE      K          AVDG W  WSSWS C A+    ++ RTRECN
Sbjct: 436 CRPPQFGGNPCEGPEKQTKFCNIALCPGRAVDGNWNEWSSWSACSASCSQGRQQRTRECN 495

Query: 591 NPAPQRGGKRCEGEKRQEEDC 611
            P+   GG  C+G   +  DC
Sbjct: 496 GPS--YGGAECQGHWVETRDC 514



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 31/116 (26%), Positives = 48/116 (41%), Gaps = 4/116 (3%)

Query: 13  NALINKGQACFCDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETRE 72
           N  +  G+A   +   W+ W++CS +C+ G Q R R+     Y      E      ETR+
Sbjct: 457 NIALCPGRAVDGNWNEWSSWSACSASCSQGRQQRTRECNGPSY---GGAECQGHWVETRD 513

Query: 73  CNWQRCPINCLLGDFGPWSDCD-PCIEKQSKVRSVLRPSQFGGQPCTAPLVAFQPC 127
           C  Q+CP++     +  W  C   C     +   V     FGG  C  P   ++ C
Sbjct: 514 CFLQQCPVDGKWQAWASWGSCSVTCGAGSQRRERVCSGPFFGGAACQGPQDEYRQC 569



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 28/82 (34%), Positives = 39/82 (47%), Gaps = 11/82 (13%)

Query: 543 CQSGTYGENCEKQSPDYK--SNA----VDGQWGCWSSWSTCDATYK---RSRTRECNNPA 593
           C S +Y   C     + +  +N+    V G W  WS WS C +T     R RTR C    
Sbjct: 381 CVSSSYSTQCSGPLREQRLCNNSAVCPVHGAWDEWSPWSLCSSTCGRGFRDRTRTCR--P 438

Query: 594 PQRGGKRCEGEKRQEEDCTFSI 615
           PQ GG  CEG ++Q + C  ++
Sbjct: 439 PQFGGNPCEGPEKQTKFCNIAL 460



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 30/116 (25%), Positives = 40/116 (34%), Gaps = 27/116 (23%)

Query: 521 CQCAPCPN-----NGRPTLSGTECLCVCQSGTYGENCEKQSPDY---------------- 559
           C  A CP      N     S + C   C  G      E   P Y                
Sbjct: 456 CNIALCPGRAVDGNWNEWSSWSACSASCSQGRQQRTRECNGPSYGGAECQGHWVETRDCF 515

Query: 560 -KSNAVDGQWGCWSSWSTCDATY---KRSRTRECNNPAPQRGGKRCEGEKRQEEDC 611
            +   VDG+W  W+SW +C  T     + R R C+ P    GG  C+G + +   C
Sbjct: 516 LQQCPVDGKWQAWASWGSCSVTCGAGSQRRERVCSGPF--FGGAACQGPQDEYRQC 569



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 20/52 (38%), Positives = 28/52 (53%), Gaps = 3/52 (5%)

Query: 28  AWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETRECNWQRCP 79
           AW  W SCS TC +G+Q R R +    ++    C+    + E R+C  QRCP
Sbjct: 527 AWASWGSCSVTCGAGSQRRER-VCSGPFFGGAACQG--PQDEYRQCGTQRCP 575



 Score = 37.4 bits (85), Expect = 0.066
 Identities = 32/100 (32%), Positives = 38/100 (38%), Gaps = 10/100 (10%)

Query: 520 PCQC----APCPNNGRPTLSGTECLCVCQSGTYGENC-EKQSPDYKSNAVDGQWGCWSSW 574
           PC C    A  P  G     G  CL    +G   ENC    + D   +   G W  WS W
Sbjct: 212 PCACLGGEAGGPAAGPLAPRGDVCLRDAVAGG-PENCLTSLTQDRGGHGATGGWKLWSLW 270

Query: 575 STCDATY---KRSRTRECNNPAPQRGGKRCEGEKRQEEDC 611
             C        ++RTR C  PAP   G  CEG   +   C
Sbjct: 271 GECTRDCGGGLQTRTRTC-LPAPGVEGGGCEGVLEEGRQC 309



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 15/50 (30%), Positives = 25/50 (50%), Gaps = 2/50 (4%)

Query: 29  WTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETRECNWQRC 78
           W+ W  C++ C  G Q+R R  +     +   CE +   +E R+CN + C
Sbjct: 267 WSLWGECTRDCGGGLQTRTRTCLPAPGVEGGGCEGVL--EEGRQCNREAC 314


>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
           motif, 5 preproprotein [Homo sapiens]
          Length = 930

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 37/155 (23%), Positives = 62/155 (40%), Gaps = 29/155 (18%)

Query: 484 DFELAPIVDLVRNIPCAVTKRNNLRKALQEYAAKFDPCQCAPCPNNGRPTLSGTEC---- 539
           ++ + P +D+   + CAV ++  +                  C     P + GT C    
Sbjct: 504 EYSVCPGMDVCARLWCAVVRQGQM-----------------VCLTKKLPAVEGTPCGKGR 546

Query: 540 LCVCQSGTYGENCEKQSPDYKSNAVDGQWGCWSSWSTCDATYK---RSRTRECNNPAPQR 596
           +C+      G+  +K    Y S +  G WG W SW  C  +     +   R CNNPAP+ 
Sbjct: 547 ICL-----QGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRN 601

Query: 597 GGKRCEGEKRQEEDCTFSIMENNGQPCINDDEEMK 631
            G+ C G++     C+      NG+   ++  E K
Sbjct: 602 NGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAK 636


>gi|134031945 SCO-spondin [Homo sapiens]
          Length = 5147

 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 30/106 (28%), Positives = 50/106 (47%), Gaps = 7/106 (6%)

Query: 29   WTQWTSCSKTCNSGTQSRHRQIVVDKYYQENF-----CEQICSKQETREC-NWQRCPINC 82
            W++WT CS+ C   T+SR R                   +  ++ +   C ++  CP++ 
Sbjct: 3414 WSEWTMCSQPCRGQTRSRSRACACPTPQHGGAPCTGEAGEAGAQHQREACPSYATCPVDG 3473

Query: 83   LLGDFGPWSDCDPCIEKQSKVRSVLR-PSQFGGQPCTAPLVAFQPC 127
              G +GPWS CD C+ +  + R+  R P+  GG+PC       +PC
Sbjct: 3474 AWGPWGPWSPCDMCLGQSHRSRACSRPPTPEGGRPCPGNHTQSRPC 3519



 Score = 58.9 bits (141), Expect = 2e-08
 Identities = 30/93 (32%), Positives = 42/93 (45%), Gaps = 10/93 (10%)

Query: 521  CQCAPCPNNGRPTLSGTECLCVCQSGTYGENCEKQS-PDYKSNAVDGQWGCWSSWSTCDA 579
            C C    + G P        C  ++G  G   ++++ P Y +  VDG WG W  WS CD 
Sbjct: 3435 CACPTPQHGGAP--------CTGEAGEAGAQHQREACPSYATCPVDGAWGPWGPWSPCDM 3486

Query: 580  TYKRS-RTRECNNPAPQRGGKRCEGEKRQEEDC 611
               +S R+R C+ P    GG+ C G   Q   C
Sbjct: 3487 CLGQSHRSRACSRPPTPEGGRPCPGNHTQSRPC 3519



 Score = 52.8 bits (125), Expect = 2e-06
 Identities = 46/157 (29%), Positives = 62/157 (39%), Gaps = 25/157 (15%)

Query: 24   CDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQE-----NFCEQICSK-QETRECNWQR 77
            C   +W  W  CS++C  G Q R R       Y+      ++C  I +  QE R CN + 
Sbjct: 3947 CSWTSWAPWEPCSRSCGVGQQRRLRA------YRPPGPGGHWCPNILTAYQERRFCNLRA 4000

Query: 78   CPINCLLGDFGPWSDCDPCIEKQSKVRS---VLRPSQFGGQPCT-----APLVAFQPCIP 129
            CP+      + PWS CD        +RS      PS+ GG PC      A L    PC  
Sbjct: 4001 CPVPGGWSRWSPWSWCDRSCGGGQSLRSRSCSSPPSKNGGAPCAGERHQARLCNPMPCEA 4060

Query: 130  SKLCKIEEADCKNKFRCDSGRC--IARKLECNGENDC 164
                 +E   C N  RC   RC  +   + C  +  C
Sbjct: 4061 GCPAGMEVVTCAN--RCPR-RCSDLQEGIVCQDDQVC 4094



 Score = 48.5 bits (114), Expect = 3e-05
 Identities = 23/49 (46%), Positives = 26/49 (53%), Gaps = 3/49 (6%)

Query: 566  GQWGCWSSWSTCDATYK---RSRTRECNNPAPQRGGKRCEGEKRQEEDC 611
            G WG W  WS C  +     RSRTR C+ P PQ  G  CEG + Q E C
Sbjct: 3253 GGWGPWGPWSHCSRSCGGGLRSRTRACDQPPPQGLGDYCEGPRAQGEVC 3301



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 34/124 (27%), Positives = 46/124 (37%), Gaps = 19/124 (15%)

Query: 531  RPTLSGTECLCVCQSGTYGENCEKQSPDYKSNAVDGQWGCWSSWSTCDATY---KRSRTR 587
            RP L G  C          +    QS   ++  V G W  W +W  C  +     +SR R
Sbjct: 2529 RPPLPGGSCP--------RDRFRSQSCFVQACPVAGAWAMWEAWGPCSVSCGGGHQSRQR 2580

Query: 588  ECNNPAPQRGGKRCEGEKRQEEDCTFSIMENNGQPCI-NDDEEMKEVDLPEIEADSGCPQ 646
             C +P P+ GG  C G  ++   C         QPC    D E+  V +       G   
Sbjct: 2581 SCVDPPPKNGGAPCPGASQERAPCGL-------QPCSGGTDCELGRVYVSADLCQKGLVP 2633

Query: 647  PVPP 650
            P PP
Sbjct: 2634 PCPP 2637



 Score = 47.0 bits (110), Expect = 8e-05
 Identities = 24/74 (32%), Positives = 36/74 (48%), Gaps = 10/74 (13%)

Query: 553  EKQSPDYKSNAVDGQWGCWSSWSTCDATY---KRSRTRECNNPAPQRGGKRCEGEKRQEE 609
            E++  + ++  V G W  WS WS CD +    +  R+R C++P  + GG  C GE+ Q  
Sbjct: 3992 ERRFCNLRACPVPGGWSRWSPWSWCDRSCGGGQSLRSRSCSSPPSKNGGAPCAGERHQAR 4051

Query: 610  DCTFSIMENNGQPC 623
             C       N  PC
Sbjct: 4052 LC-------NPMPC 4058



 Score = 46.6 bits (109), Expect = 1e-04
 Identities = 26/84 (30%), Positives = 36/84 (42%), Gaps = 9/84 (10%)

Query: 525  PCPNNGRPTLSGTECLCVCQSGTYGENCEKQSPDYKSNA-------VDGQWGCWSSWSTC 577
            PC     P   G    C        +NC    P+++S A       VDG+W  WS WS C
Sbjct: 1705 PCSRTCGPWGQGRSRRCSPLGLLVLQNCP--GPEHQSQACFTAACPVDGEWSTWSPWSVC 1762

Query: 578  DATYKRSRTRECNNPAPQRGGKRC 601
                + + TR+    +PQ GG+ C
Sbjct: 1763 SEPCRGTMTRQRQCHSPQNGGRTC 1786



 Score = 45.8 bits (107), Expect = 2e-04
 Identities = 55/226 (24%), Positives = 77/226 (34%), Gaps = 43/226 (19%)

Query: 568  WGCWSSWSTCDATYK---RSRTRECNNPAPQRGGKRCEGEKRQEEDCTFSIMENNGQPCI 624
            WG W+ WSTC A      ++R R C++ AP  G   C G   Q  DC       N QPC 
Sbjct: 2833 WGLWAPWSTCSAPCDGGIQTRGRSCSSLAP--GDTTCPGPHSQTRDC-------NTQPC- 2882

Query: 625  NDDEEMKEVDLPEIEADSGCPQPVPPENGFIRNEKQLYLVGEDVEISCLT---GFETVGY 681
                             + C     PEN   R+ +Q +  G      CLT   G E  G+
Sbjct: 2883 ----------------TAQC-----PENMLFRSAEQCHQEGGPCPRLCLTQGPGIECTGF 2921

Query: 682  QYFRC-LPDGTWRQGDVECQRTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAG 740
                C  P G +        R++C   +  ++       RL         TC  G +   
Sbjct: 2922 CAPGCTCPPGLFLHNASCLPRSQCPCQLHGQLYASGAMARL---DSCNNCTCVSGKMACT 2978

Query: 741  PSR--YTCQGNSWTPPISNSLTCEKDTLTKLKGHCQLGQKQSGSEC 784
              R    C  + WT     S +C      + +          G+EC
Sbjct: 2979 SERCPVACGWSPWTLWSLCSCSCNVGIRRRFRAGTAPPAAFGGAEC 3024



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 18/32 (56%), Positives = 20/32 (62%)

Query: 143  KFRCDSGRCIARKLECNGENDCGDNSDERDCG 174
            +FRC SG C  R   C+ E DC D SDER CG
Sbjct: 1569 EFRCGSGECTPRGWRCDQEEDCADGSDERGCG 1600



 Score = 45.4 bits (106), Expect = 2e-04
 Identities = 33/110 (30%), Positives = 46/110 (41%), Gaps = 11/110 (10%)

Query: 24   CDHYAWTQWTSCSKTCNSGTQSRHRQ-IVVDKYYQENFCEQICSKQETRECNWQRCPINC 82
            C    WT W+ CS +CN G + R R        +    C+      E   C+ + CP   
Sbjct: 2986 CGWSPWTLWSLCSCSCNVGIRRRFRAGTAPPAAFGGAECQG--PTMEAEFCSLRPCPGPG 3043

Query: 83   LLGDFGPWSDCD-PC-----IEKQSKVRSVLRPSQFGGQPCTAPLVAFQP 126
              G++GPWS C  PC        +   RS++  S  G QPC  P+    P
Sbjct: 3044 --GEWGPWSPCSVPCGGGYRNRTRGSSRSLMEFSTCGLQPCAGPVPGMCP 3091



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 34/101 (33%), Positives = 45/101 (44%), Gaps = 15/101 (14%)

Query: 520  PCQCAPCPNNGRPTLSG----TEC-LCVCQSGTYGENCEKQSPDYKSNAVDGQWGCWSSW 574
            P QC PC  +G     G     +C LC+CQ G     C + +PD    AVD  W  WS W
Sbjct: 1865 PRQC-PCLVDGARYWPGQRIKADCQLCICQDGR-PRRC-RLNPDC---AVDCGWSSWSPW 1918

Query: 575  STC----DATYKRSRTRECNNPAPQRGGKRCEGEKRQEEDC 611
            + C     +   +   R  NNP P   G++C G  R+   C
Sbjct: 1919 AKCLGPCGSQSIQWSFRSSNNPRPSGRGRQCRGIHRKARRC 1959



 Score = 45.1 bits (105), Expect = 3e-04
 Identities = 32/108 (29%), Positives = 44/108 (40%), Gaps = 26/108 (24%)

Query: 564  VDGQWGCWSSWSTCDATYK---RSRTRECNNPAPQRGGKRCEGE------KRQEEDC-TF 613
            V G W  WS W+ C    +   RSR+R C  P PQ GG  C GE      + Q E C ++
Sbjct: 3407 VPGGWCPWSEWTMCSQPCRGQTRSRSRACACPTPQHGGAPCTGEAGEAGAQHQREACPSY 3466

Query: 614  SIMENNG--------QPCINDDEEMKEVDLPEIEADSGCPQPVPPENG 653
            +    +G         PC        ++ L +      C +P  PE G
Sbjct: 3467 ATCPVDGAWGPWGPWSPC--------DMCLGQSHRSRACSRPPTPEGG 3506



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 28/106 (26%), Positives = 42/106 (39%), Gaps = 4/106 (3%)

Query: 28   AWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETRECNWQRCPINCLLGDF 87
            +W  W  CS++C  G  SR           +  C       +T+ C    CP  C+   +
Sbjct: 4312 SWGPWGPCSRSCGPGLASRSGSCPCLMAKADPTCNSTFLHLDTQGCYSGPCPEECVWSSW 4371

Query: 88   GPWSDCDPCIEKQSKVRSVLRPSQFG---GQPCTAPLVAFQPCIPS 130
              W+ C   +  Q + R    P+  G   G PCT     F+PC+ S
Sbjct: 4372 SSWTRCSCRVLVQQRYRH-QGPASRGARAGAPCTRLDGHFRPCLIS 4416



 Score = 43.1 bits (100), Expect = 0.001
 Identities = 18/47 (38%), Positives = 27/47 (57%), Gaps = 3/47 (6%)

Query: 568  WGCWSSWSTCDATYK---RSRTRECNNPAPQRGGKRCEGEKRQEEDC 611
            W  WSSW+ CD +     R+R R  +NP    GG  CEG++++ + C
Sbjct: 2718 WSAWSSWAPCDRSCGSGVRARFRSPSNPPAAWGGAPCEGDRQELQGC 2764



 Score = 42.7 bits (99), Expect = 0.002
 Identities = 35/129 (27%), Positives = 48/129 (37%), Gaps = 27/129 (20%)

Query: 29   WTQWTSCSKTCNS-GTQSRHRQIVVDKYYQENFCEQIC-SKQETRECNWQRCP------- 79
            W+ W  CS++C   GT++R RQ V+          Q C   ++  EC    CP       
Sbjct: 3817 WSPWGPCSRSCGGLGTRTRSRQCVLT---MPTLSGQGCRGPRQDLECPSPDCPGAEGSTV 3873

Query: 80   --INCLLGDFGPWSDCDPCIEK---------QSKVRSVLRPSQFGG----QPCTAPLVAF 124
              +  L G +GPWS   PC            +S+ R  L     G     +PC  P    
Sbjct: 3874 EPVTGLPGGWGPWSSWSPCSRSCTDPARPAWRSRTRLCLANCTMGDPLQERPCNLPSCTE 3933

Query: 125  QPCIPSKLC 133
             P  P   C
Sbjct: 3934 LPVCPGPGC 3942



 Score = 42.4 bits (98), Expect = 0.002
 Identities = 26/92 (28%), Positives = 40/92 (43%), Gaps = 4/92 (4%)

Query: 29   WTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETRECNWQRCPINCLLGDFG 88
            W+ W  CS+TC    Q R R+           C     + +++ C    CP++     + 
Sbjct: 1700 WSPWGPCSRTCGPWGQGRSRRCSPLGLLVLQNCPG--PEHQSQACFTAACPVDGEWSTWS 1757

Query: 89   PWSDC-DPCIEKQSKVRSVLRPSQFGGQPCTA 119
            PWS C +PC    ++ R    P Q GG+ C A
Sbjct: 1758 PWSVCSEPCRGTMTRQRQCHSP-QNGGRTCAA 1788



 Score = 40.8 bits (94), Expect = 0.006
 Identities = 46/178 (25%), Positives = 64/178 (35%), Gaps = 44/178 (24%)

Query: 24   CDHYAWTQWTSCSKTCNSGTQSRHRQ----------IVVDKYYQE-NFCEQICSKQE--- 69
            C   AW+ W  C ++C SG ++R R              +   QE   C  +C  +    
Sbjct: 2716 CGWSAWSSWAPCDRSCGSGVRARFRSPSNPPAAWGGAPCEGDRQELQGCHTVCGTEVFGW 2775

Query: 70   TRECNWQRCPINCLLGDFGP-WSDCDPCIEKQSKVRSVLRPSQFGGQPCTAPLVAFQPCI 128
            T   +W  C  +CL    GP W           + RS L PS  G   C       +PC 
Sbjct: 2776 TPWTSWSSCSQSCLAPGGGPGW-----------RSRSRLCPSP-GDSSCPGDATQEEPCS 2823

Query: 129  PSKLCKIEE--------ADCKNKFRCDSGRCIARKLECN----GENDC-GDNSDERDC 173
            P  +C +          + C     CD G    R   C+    G+  C G +S  RDC
Sbjct: 2824 P-PVCPVPSIWGLWAPWSTCSAP--CDGG-IQTRGRSCSSLAPGDTTCPGPHSQTRDC 2877



 Score = 40.4 bits (93), Expect = 0.008
 Identities = 35/116 (30%), Positives = 43/116 (37%), Gaps = 23/116 (19%)

Query: 29   WTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCE-----QICSKQET---RECNWQRCPI 80
            W+ W+SCS  C  GT  RHR            CE       C  Q+T   +ECN Q CP 
Sbjct: 4769 WSAWSSCSAPCGGGTMERHRT-----------CEGGPGVAPCQAQDTEQRQECNLQPCP- 4816

Query: 81   NCLLGD-FGPWSDCDPCI--EKQSKVRSVLRPSQFGGQPCTAPLVAFQPCIPSKLC 133
             C  G      +   PC+    Q     V  P Q G       L+    C+P   C
Sbjct: 4817 ECPPGQVLSACATSCPCLCWHLQPGAICVQEPCQPGCGCPGGQLLHNGTCVPPTAC 4872



 Score = 39.3 bits (90), Expect = 0.017
 Identities = 30/105 (28%), Positives = 45/105 (42%), Gaps = 12/105 (11%)

Query: 29   WTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETRECNWQRCPINCLLGDFG 88
            W+ W+SCS++C  G  +  RQ ++        C +   +  ++ C  Q CP+    G + 
Sbjct: 2506 WSVWSSCSRSCGLGL-TFQRQELLRPPLPGGSCPR--DRFRSQSCFVQACPV---AGAWA 2559

Query: 89   PWSDCDPCIEK-----QSKVRS-VLRPSQFGGQPCTAPLVAFQPC 127
             W    PC        QS+ RS V  P + GG PC        PC
Sbjct: 2560 MWEAWGPCSVSCGGGHQSRQRSCVDPPPKNGGAPCPGASQERAPC 2604



 Score = 38.9 bits (89), Expect = 0.023
 Identities = 33/118 (27%), Positives = 52/118 (44%), Gaps = 20/118 (16%)

Query: 22   CFCDHYAWTQWT---SCSKTC-----NSGTQSRHRQIVVDKYYQENFCEQICSKQETREC 73
            C  + + WT WT   SCS++C       G +SR R   +     ++ C    +++E   C
Sbjct: 2768 CGTEVFGWTPWTSWSSCSQSCLAPGGGPGWRSRSR---LCPSPGDSSCPGDATQEE--PC 2822

Query: 74   NWQRCPINCLLGDFGPWSDCD-PC---IEKQSKVRSVLRPSQFGGQPCTAPLVAFQPC 127
            +   CP+  + G + PWS C  PC   I+ + +  S L P   G   C  P    + C
Sbjct: 2823 SPPVCPVPSIWGLWAPWSTCSAPCDGGIQTRGRSCSSLAP---GDTTCPGPHSQTRDC 2877



 Score = 38.1 bits (87), Expect = 0.039
 Identities = 31/101 (30%), Positives = 39/101 (38%), Gaps = 19/101 (18%)

Query: 522  QCAPCPNNGRPTLSGTECLCVCQSGTYGEN-----CEKQSP-------DYKSNAVDGQWG 569
            Q  PCP    P L    CL   +S T G++     C++ S        +    AV   W 
Sbjct: 4202 QSQPCPQPSCPPL----CLQGTRSRTLGDSWLQGECQRCSCTPEGVICEDTECAVPEAWT 4257

Query: 570  CWSSWSTCDATY---KRSRTRECNNPAPQRGGKRCEGEKRQ 607
             WSSWS C  +     + RTR C   AP      C G   Q
Sbjct: 4258 LWSSWSDCPVSCGGGNQVRTRACRAAAPHHRSPPCLGPDTQ 4298



 Score = 37.4 bits (85), Expect = 0.066
 Identities = 29/100 (29%), Positives = 40/100 (40%), Gaps = 20/100 (20%)

Query: 520  PCQCAPCPNNGRPTLSGTECLCVCQS-----GTYGENCEKQSPDYKSNAVDGQWGCWSSW 574
            PC    CPN    T  G + +C  Q      G  G + E+Q          G WG WS W
Sbjct: 1655 PCPEYTCPNG---TCIGFQLVCDGQPDCGRPGQVGPSPEEQGC--------GAWGPWSPW 1703

Query: 575  STCDAT---YKRSRTRECNNPAPQRGGKRCEGEKRQEEDC 611
              C  T   + + R+R C +P      + C G + Q + C
Sbjct: 1704 GPCSRTCGPWGQGRSRRC-SPLGLLVLQNCPGPEHQSQAC 1742



 Score = 37.0 bits (84), Expect = 0.086
 Identities = 15/29 (51%), Positives = 17/29 (58%)

Query: 145  RCDSGRCIARKLECNGENDCGDNSDERDC 173
            RC SG C+ R   C+G  DC D SDE  C
Sbjct: 2240 RCASGECVLRGGPCDGVLDCEDGSDEEGC 2268



 Score = 36.6 bits (83), Expect = 0.11
 Identities = 36/159 (22%), Positives = 53/159 (33%), Gaps = 40/159 (25%)

Query: 29   WTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICS--------KQETRECNWQ---- 76
            W  W++CS  C+ G Q+R R            C  +            +TR+CN Q    
Sbjct: 2836 WAPWSTCSAPCDGGIQTRGRS-----------CSSLAPGDTTCPGPHSQTRDCNTQPCTA 2884

Query: 77   RCPINCLLGDFGPWSDC----DPCIEKQSKVRSVLRPSQFGGQPCTAPLVAF---QPCIP 129
            +CP N L   F     C     PC          +  + F    CT P   F     C+P
Sbjct: 2885 QCPENML---FRSAEQCHQEGGPCPRLCLTQGPGIECTGFCAPGCTCPPGLFLHNASCLP 2941

Query: 130  SKLCKIE-------EADCKNKFRCDSGRCIARKLECNGE 161
               C  +                C++  C++ K+ C  E
Sbjct: 2942 RSQCPCQLHGQLYASGAMARLDSCNNCTCVSGKMACTSE 2980



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 31/113 (27%), Positives = 40/113 (35%), Gaps = 14/113 (12%)

Query: 29   WTQWTSCSKTCNSGTQSRHR---------QIVVDKYYQENFCEQICSKQETRE--CNWQR 77
            WT W+ CS +C      RHR            V           +CS  E  E  C  Q 
Sbjct: 3189 WTPWSQCSASCGPARCHRHRFCARSPSAVPSTVAPLPLPATPTPLCSGPEAEEEPCLLQG 3248

Query: 78   CPINCLLGDFGPWSDCDPCI--EKQSKVRSVLRPSQFG-GQPCTAPLVAFQPC 127
            C      G +GPWS C        +S+ R+  +P   G G  C  P    + C
Sbjct: 3249 CDRAGGWGPWGPWSHCSRSCGGGLRSRTRACDQPPPQGLGDYCEGPRAQGEVC 3301



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 18/51 (35%), Positives = 26/51 (50%), Gaps = 5/51 (9%)

Query: 565  DGQWGCWSSWSTCDATY----KRSRTRECNNPAPQRGGKRCEGEKRQEEDC 611
            DG +G WS W  C  +      R+R+R+C    P   G+ C G  RQ+ +C
Sbjct: 3811 DGGFGPWSPWGPCSRSCGGLGTRTRSRQCVLTMPTLSGQGCRG-PRQDLEC 3860



 Score = 34.7 bits (78), Expect = 0.43
 Identities = 15/41 (36%), Positives = 22/41 (53%), Gaps = 5/41 (12%)

Query: 133  CKIEEADCKNKFRCDSGRCIARKLECNGENDCGDNSDERDC 173
            C   EA C+     ++G C+     C+ ++DCGD SDE  C
Sbjct: 1376 CAEGEALCQ-----ENGHCVPHGWLCDNQDDCGDGSDEEGC 1411



 Score = 34.7 bits (78), Expect = 0.43
 Identities = 12/30 (40%), Positives = 19/30 (63%)

Query: 141  KNKFRCDSGRCIARKLECNGENDCGDNSDE 170
            + +  C SG C+   L C+ ++DCGD +DE
Sbjct: 1418 EGQMTCSSGHCLPLALLCDRQDDCGDGTDE 1447



 Score = 34.7 bits (78), Expect = 0.43
 Identities = 18/59 (30%), Positives = 24/59 (40%), Gaps = 12/59 (20%)

Query: 127  CIPSKLCKIEEADC------------KNKFRCDSGRCIARKLECNGENDCGDNSDERDC 173
            C+P  L    + DC            +    C  GRC+   L C+G  DC D +DE  C
Sbjct: 1428 CLPLALLCDRQDDCGDGTDEPSYPCPQGLLACADGRCLPPALLCDGHPDCLDAADEESC 1486



 Score = 34.7 bits (78), Expect = 0.43
 Identities = 30/115 (26%), Positives = 45/115 (39%), Gaps = 28/115 (24%)

Query: 63   QICSKQETREC----NWQRCPINCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCT 118
            Q+C  +E  +C    + + C  N L+     W    P +   S V  ++      G P +
Sbjct: 2408 QVCDGRE--DCLDGSDERHCARNLLM-----WLPSLPALWAASTVPFMMPTMALPGLPAS 2460

Query: 119  APLVAFQPCIPSKLCKIEEADCKNKFRCDSGRCIARKLECNGENDCGDNSDERDC 173
              L     C PS+L             C SG C++ +  C+   DC D SDE  C
Sbjct: 2461 RAL-----CSPSQLS------------CGSGECLSAERRCDLRPDCQDGSDEDGC 2498



 Score = 34.7 bits (78), Expect = 0.43
 Identities = 40/150 (26%), Positives = 56/150 (37%), Gaps = 32/150 (21%)

Query: 61   CEQ-ICSKQETRECNWQRCPINCLLGDFGPWSDCDPCIEKQSKVRSVLR-----PSQFGG 114
            C Q +C K E   C    CP+ C    +  W+ CD      S VR+  R     P+ +GG
Sbjct: 2695 CSQCVCEKGELL-CQPGGCPLPCGWSAWSSWAPCDRSC--GSGVRARFRSPSNPPAAWGG 2751

Query: 115  QPCTAPLVAFQPCIPSKLCKIEE---------ADCKNKFRCDSG----RCIARKLECNGE 161
             PC       Q C    +C  E          + C        G    R  +R     G+
Sbjct: 2752 APCEGDRQELQGC--HTVCGTEVFGWTPWTSWSSCSQSCLAPGGGPGWRSRSRLCPSPGD 2809

Query: 162  NDC-GDNSDERDCGRTKAVCTRKYNPIPSV 190
            + C GD + E  C  +  VC     P+PS+
Sbjct: 2810 SSCPGDATQEEPC--SPPVC-----PVPSI 2832



 Score = 34.7 bits (78), Expect = 0.43
 Identities = 22/82 (26%), Positives = 30/82 (36%), Gaps = 10/82 (12%)

Query: 541  CVCQSGTYGENCEKQSPDYKSNAVDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKR 600
            C C +G     C+ + PD     V   WG W   S      ++ R+R C  P        
Sbjct: 3627 CTCVAGIL--QCQ-EVPDCPDPGVWSSWGPWEDCSVSCGGGEQLRSRRCARPP------- 3676

Query: 601  CEGEKRQEEDCTFSIMENNGQP 622
            C G  RQ   C+  +    G P
Sbjct: 3677 CPGPARQSRTCSTQVCREAGCP 3698



 Score = 34.3 bits (77), Expect = 0.56
 Identities = 28/100 (28%), Positives = 36/100 (36%), Gaps = 17/100 (17%)

Query: 522  QCAPCPNNGRPTLSGTECL------CVCQSGTYGENCEKQSPDYKSNAVDGQWGCWSSWS 575
            QC PC  +G+   SG          C C SG      E+         V   W  W+ WS
Sbjct: 2944 QC-PCQLHGQLYASGAMARLDSCNNCTCVSGKMACTSERCP-------VACGWSPWTLWS 2995

Query: 576  TCDATYK---RSRTRECNNPAPQRGGKRCEGEKRQEEDCT 612
             C  +     R R R    P    GG  C+G   + E C+
Sbjct: 2996 LCSCSCNVGIRRRFRAGTAPPAAFGGAECQGPTMEAEFCS 3035



 Score = 33.9 bits (76), Expect = 0.73
 Identities = 13/30 (43%), Positives = 17/30 (56%)

Query: 146  CDSGRCIARKLECNGENDCGDNSDERDCGR 175
            C+   C+ +   C+G  DC D SDER C R
Sbjct: 2398 CEVLGCVEQAQVCDGREDCLDGSDERHCAR 2427



 Score = 33.9 bits (76), Expect = 0.73
 Identities = 23/81 (28%), Positives = 33/81 (40%), Gaps = 12/81 (14%)

Query: 24   CDHYAWTQWTSCSKTCN-SGTQSRHRQIVVDKYYQENFCEQICSKQETRECNWQRCPINC 82
            C    W+ W+ CS +C   G QSR R      +  E  C +   + +++ C    CP  C
Sbjct: 4160 CAWSHWSAWSPCSHSCGPRGQQSRFRSSTSGSWAPE--CRE--EQSQSQPCPQPSCPPLC 4215

Query: 83   L-------LGDFGPWSDCDPC 96
            L       LGD     +C  C
Sbjct: 4216 LQGTRSRTLGDSWLQGECQRC 4236



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 21/71 (29%), Positives = 34/71 (47%), Gaps = 8/71 (11%)

Query: 29   WTQWTSCSKTCNSGTQSRHRQIVVDKYYQE---NFCEQICSKQETRECNWQRCPI-NCLL 84
            W  W+ CS++C  G +SR R    D+   +   ++CE   ++ E   C    CP+ NC  
Sbjct: 3258 WGPWSHCSRSCGGGLRSRTR--ACDQPPPQGLGDYCEGPRAQGEV--CQALPCPVTNCTA 3313

Query: 85   GDFGPWSDCDP 95
             +   +S C P
Sbjct: 3314 IEGAEYSPCGP 3324



 Score = 33.1 bits (74), Expect = 1.2
 Identities = 26/74 (35%), Positives = 29/74 (39%), Gaps = 22/74 (29%)

Query: 532  PTLSGTECLCVCQSGTYGENCEKQSPDYKS---------NAVDGQWGCWSSWSTCDATYK 582
            PTLSG  C    Q      + E  SPD              + G WG WSSWS C  +  
Sbjct: 3844 PTLSGQGCRGPRQ------DLECPSPDCPGAEGSTVEPVTGLPGGWGPWSSWSPCSRSCT 3897

Query: 583  -------RSRTREC 589
                   RSRTR C
Sbjct: 3898 DPARPAWRSRTRLC 3911



 Score = 32.0 bits (71), Expect = 2.8
 Identities = 13/38 (34%), Positives = 22/38 (57%), Gaps = 6/38 (15%)

Query: 143  KFRCDSGRCIARKLECNGENDC------GDNSDERDCG 174
            ++ C +G CI  +L C+G+ DC      G + +E+ CG
Sbjct: 1658 EYTCPNGTCIGFQLVCDGQPDCGRPGQVGPSPEEQGCG 1695



 Score = 31.6 bits (70), Expect = 3.6
 Identities = 28/112 (25%), Positives = 38/112 (33%), Gaps = 25/112 (22%)

Query: 520  PCQCAPCPNNGRPTLSGTECL-----CVCQSGTYGENCEKQSPDYKSNAVDGQWGCWSSW 574
            P Q  PC + G     G+  +     C C SG    NC      +     +  W  W+ W
Sbjct: 3138 PTQDCPCAHEGHLYPPGSTVVRPCENCSCVSGLIA-NCSS----WPCAEGEPTWSPWTPW 3192

Query: 575  STCDAT---YKRSRTRECNN------------PAPQRGGKRCEGEKRQEEDC 611
            S C A+    +  R R C              P P      C G + +EE C
Sbjct: 3193 SQCSASCGPARCHRHRFCARSPSAVPSTVAPLPLPATPTPLCSGPEAEEEPC 3244



 Score = 30.8 bits (68), Expect = 6.2
 Identities = 20/59 (33%), Positives = 24/59 (40%), Gaps = 3/59 (5%)

Query: 29   WTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETRECNWQRCP--INCLLG 85
            W  W  CS +C  G QSR R   VD   +        + QE   C  Q C    +C LG
Sbjct: 2561 WEAWGPCSVSCGGGHQSRQRS-CVDPPPKNGGAPCPGASQERAPCGLQPCSGGTDCELG 2618



 Score = 30.8 bits (68), Expect = 6.2
 Identities = 18/66 (27%), Positives = 28/66 (42%), Gaps = 6/66 (9%)

Query: 29   WTQWTSCSKTCNSGTQSRHRQI-VVDKYYQENFCEQICSKQETRECNWQRCPINCLLGDF 87
            W+ W+ C  +C  G Q R R       +++   C  +    +TR+   Q CP       +
Sbjct: 4259 WSSWSDCPVSCGGGNQVRTRACRAAAPHHRSPPC--LGPDTQTRQ---QPCPGLLEACSW 4313

Query: 88   GPWSDC 93
            GPW  C
Sbjct: 4314 GPWGPC 4319



 Score = 30.4 bits (67), Expect = 8.0
 Identities = 16/59 (27%), Positives = 26/59 (44%), Gaps = 5/59 (8%)

Query: 73   CNWQRCPINCLLGDFGPWS----DCDPCIEKQSKVRSVLRPSQFGGQPCTAPLVAFQPC 127
            C  +RCP+ C    +  WS     C+  I ++ +      P+ FGG  C  P +  + C
Sbjct: 2977 CTSERCPVACGWSPWTLWSLCSCSCNVGIRRRFRA-GTAPPAAFGGAECQGPTMEAEFC 3034


>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
           10 preproprotein [Homo sapiens]
          Length = 1103

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 37/122 (30%), Positives = 53/122 (43%), Gaps = 18/122 (14%)

Query: 526 CPNNGRPTLSGTECLCVCQSGTYGEN-CEKQSP---DYKSNAVDGQWGCWSSWSTCDATY 581
           C  N  P   GT    +CQ+ T  +  C K+       +   VDG WG W+ W  C  T 
Sbjct: 508 CITNSIPAAEGT----LCQTHTIDKGWCYKRVCVPFGSRPEGVDGAWGPWTPWGDCSRTC 563

Query: 582 K---RSRTRECNNPAPQRGGKRCEGEKRQEEDCTFSIMENNGQPCINDDEEMKEVDLPEI 638
                S +R C++P P  GGK C GE+R+   C       N   C    ++ +EV   E 
Sbjct: 564 GGGVSSSSRHCDSPRPTIGGKYCLGERRRHRSC-------NTDDCPPGSQDFREVQCSEF 616

Query: 639 EA 640
           ++
Sbjct: 617 DS 618



 Score = 33.5 bits (75), Expect = 0.95
 Identities = 19/57 (33%), Positives = 25/57 (43%), Gaps = 13/57 (22%)

Query: 29  WTQWTSCSKTCNSG--TQSRH----RQIVVDKYYQENFCEQICSKQETRECNWQRCP 79
           WT W  CS+TC  G  + SRH    R  +  KY        +  ++  R CN   CP
Sbjct: 553 WTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYC-------LGERRRHRSCNTDDCP 602



 Score = 33.5 bits (75), Expect = 0.95
 Identities = 23/87 (26%), Positives = 38/87 (43%), Gaps = 9/87 (10%)

Query: 27  YAW--TQWTSCSKTCNSGTQSRH---RQIVVDKYYQENFCEQICS-KQETRECNWQRCPI 80
           Y+W    WT CS  C  G+Q +    R  +       ++C       +  R CN + CP 
Sbjct: 827 YSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQRACNTEPCPP 886

Query: 81  NCLLGDFGPWSDCDPCIEKQSKVRSVL 107
           + ++G+   WS C    +   + RSV+
Sbjct: 887 DWVVGN---WSLCSRSCDAGVRSRSVV 910



 Score = 32.7 bits (73), Expect = 1.6
 Identities = 43/171 (25%), Positives = 63/171 (36%), Gaps = 23/171 (13%)

Query: 32   WTSCSKTCNSGTQSR----HRQI--VVDKYYQENFCEQICSKQETRECNWQRCPINCLLG 85
            W+ CS++C++G +SR     R++    +K   ++ C Q         C+   CP      
Sbjct: 893  WSLCSRSCDAGVRSRSVVCQRRVSAAEEKALDDSACPQ-PRPPVLEACHGPTCPPEWAAL 951

Query: 86   DFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAPLVAFQPCIPSKLCKIEEADCKNKFR 145
            D   WS+C P      + R VL  S       T P     P   S   K       N  R
Sbjct: 952  D---WSECTPSCGPGLRHRVVLCKS--ADHRATLP-----PAHCSPAAKPPATMRCNLRR 1001

Query: 146  CDSGRCIARKL-ECNGENDCGDNSDERDC----GRTKAVCTRKYNPIPSVQ 191
            C   R +A +  EC+ +   G       C    G+    CT    P P+ Q
Sbjct: 1002 CPPARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRP-PTTQ 1051


>gi|62243567 netrin receptor Unc5h1 [Homo sapiens]
          Length = 842

 Score = 58.5 bits (140), Expect = 3e-08
 Identities = 22/49 (44%), Positives = 29/49 (59%)

Query: 564 VDGQWGCWSSWSTCDATYKRSRTRECNNPAPQRGGKRCEGEKRQEEDCT 612
           VDG W  WS WS C       R+REC++PAP+ GG+ C+G      +CT
Sbjct: 241 VDGSWSPWSKWSACGLDCTHWRSRECSDPAPRNGGEECQGTDLDTRNCT 289


>gi|110347423 spondin 1, extracellular matrix protein [Homo sapiens]
          Length = 807

 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 27/91 (29%), Positives = 46/91 (50%), Gaps = 6/91 (6%)

Query: 29  WTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETRECNWQRCPINCLLGDFG 88
           W++W+ CS TC  G ++R R +      +   C +    ++  +C    CPI+C L ++ 
Sbjct: 620 WSEWSDCSVTCGKGMRTRQRML--KSLAELGDCNE--DLEQVEKCMLPECPIDCELTEWS 675

Query: 89  PWSDCDPCIEKQSKVRS--VLRPSQFGGQPC 117
            WS+C+    K   +R+  +    QFGG PC
Sbjct: 676 QWSECNKSCGKGHVIRTRMIQMEPQFGGAPC 706



 Score = 50.4 bits (119), Expect = 8e-06
 Identities = 42/160 (26%), Positives = 67/160 (41%), Gaps = 18/160 (11%)

Query: 24  CDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETREC--NWQRCPIN 81
           C    W  W+ CS +C  G +SR R +   K + E+        +ET +C  N +  P +
Sbjct: 502 CTMSEWITWSPCSISCGMGMRSRERYV---KQFPEDGSVCTLPTEETEKCTVNEECSPSS 558

Query: 82  CLLGDFGPWSDCD-PCIEKQSKVRSVLRPSQFGGQPCTAPLVAFQPC-------IPSKLC 133
           CL+ ++G W +C   C     K   +++ +   G  C A     + C       IP  L 
Sbjct: 559 CLMTEWGEWDECSATCGMGMKKRHRMIKMNPADGSMCKAETSQAEKCMMPECHTIPCLLS 618

Query: 134 KIEE-ADCKNKFRCDSG-RCIARKLECNGE-NDCGDNSDE 170
              E +DC     C  G R   R L+   E  DC ++ ++
Sbjct: 619 PWSEWSDC--SVTCGKGMRTRQRMLKSLAELGDCNEDLEQ 656



 Score = 50.1 bits (118), Expect = 1e-05
 Identities = 36/136 (26%), Positives = 56/136 (41%), Gaps = 13/136 (9%)

Query: 29  WTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETRECNWQRC-PINCLLGDF 87
           W +W  CS TC  G + RHR I ++     + C+   S+ E  +C    C  I CLL  +
Sbjct: 564 WGEWDECSATCGMGMKKRHRMIKMNP-ADGSMCKAETSQAE--KCMMPECHTIPCLLSPW 620

Query: 88  GPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAPLVAFQPCIPSKL---CKIEE----ADC 140
             WSDC     K  + R  +  S      C   L   + C+  +    C++ E    ++C
Sbjct: 621 SEWSDCSVTCGKGMRTRQRMLKSLAELGDCNEDLEQVEKCMLPECPIDCELTEWSQWSEC 680

Query: 141 KNKFRCDSGRCIARKL 156
                C  G  I  ++
Sbjct: 681 NKS--CGKGHVIRTRM 694



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 18/55 (32%), Positives = 26/55 (47%), Gaps = 2/55 (3%)

Query: 24  CDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETRECNWQRC 78
           C    WT W+ C+K C  G Q R+  + V K ++ +       K+E R CN   C
Sbjct: 755 CRMRPWTAWSECTKLCGGGIQERY--MTVKKRFKSSQFTSCKDKKEIRACNVHPC 807



 Score = 35.4 bits (80), Expect = 0.25
 Identities = 14/55 (25%), Positives = 28/55 (50%), Gaps = 3/55 (5%)

Query: 24  CDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETRECNWQRC 78
           C+   W+QW+ C+K+C  G   R R I ++  +    C +   +   ++C  ++C
Sbjct: 669 CELTEWSQWSECNKSCGKGHVIRTRMIQMEPQFGGAPCPETVQR---KKCRIRKC 720



 Score = 34.3 bits (77), Expect = 0.56
 Identities = 25/116 (21%), Positives = 43/116 (37%), Gaps = 10/116 (8%)

Query: 24  CDHYAWTQWTSC-SKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETRECNWQRCP--- 79
           C +  W+ W++C S TC+ G + R R +      Q +        Q+ + C    C    
Sbjct: 443 CIYSNWSPWSACSSSTCDKGKRMRQRMLKA----QLDLSVPCPDTQDFQPCMGPGCSDED 498

Query: 80  -INCLLGDFGPWSDCD-PCIEKQSKVRSVLRPSQFGGQPCTAPLVAFQPCIPSKLC 133
              C + ++  WS C   C          ++     G  CT P    + C  ++ C
Sbjct: 499 GSTCTMSEWITWSPCSISCGMGMRSRERYVKQFPEDGSVCTLPTEETEKCTVNEEC 554


>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif,
           3 proprotein [Homo sapiens]
          Length = 1205

 Score = 58.2 bits (139), Expect = 4e-08
 Identities = 35/106 (33%), Positives = 49/106 (46%), Gaps = 16/106 (15%)

Query: 518 FDPCQ---CAP------CPNNGRPTLSGTECLCVCQSGTYGENCEKQSPDYKSNAVDGQW 568
           FDPC+   C+       C     P L GTEC        Y  +C  ++ + +    DG W
Sbjct: 499 FDPCKQLWCSHPDNPYFCKTKKGPPLDGTEC--AAGKWCYKGHCMWKNANQQKQ--DGNW 554

Query: 569 GCWSSWSTCDATYK---RSRTRECNNPAPQRGGKRCEGEKRQEEDC 611
           G W+ + +C  T     R RTR+CNNP P  GG+ C G   + + C
Sbjct: 555 GSWTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLC 600



 Score = 39.7 bits (91), Expect = 0.013
 Identities = 36/135 (26%), Positives = 57/135 (42%), Gaps = 29/135 (21%)

Query: 24   CDHYAWT--QWTSCSKTC-NSGTQSRHRQIV------VDKYYQENFCEQICSKQETRE-C 73
            C H  W   +W  C+KTC +SG Q R  + +       ++     +C  +  + E+R  C
Sbjct: 904  CTHPLWVAEEWEHCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYC--MGDRPESRRPC 961

Query: 74   NWQRCPINCLLGDFGPWSDCDPCIEKQSKVRSVL----------RPSQFGGQPCTAPLVA 123
            N   CP        GPWS+C     + ++VR VL          +P     + C  P   
Sbjct: 962  NRVPCPAQ---WKTGPWSECSVTCGEGTEVRQVLCRAGDHCDGEKPESV--RACQLPPCN 1016

Query: 124  FQPCIPSK--LCKIE 136
             +PC+  K   C++E
Sbjct: 1017 DEPCLGDKSIFCQME 1031



 Score = 31.2 bits (69), Expect = 4.7
 Identities = 11/22 (50%), Positives = 17/22 (77%)

Query: 28  AWTQWTSCSKTCNSGTQSRHRQ 49
           +WT++ SCS+TC +G + R RQ
Sbjct: 556 SWTKFGSCSRTCGTGVRFRTRQ 577


>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif,
           9 preproprotein [Homo sapiens]
          Length = 1935

 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 48/179 (26%), Positives = 69/179 (38%), Gaps = 35/179 (19%)

Query: 526 CPNNGRPTLSGTECLCVCQSGTYGENCEKQSPDYKSNAV---DGQWGCWSSWSTCDATYK 582
           C     P   GTEC         G++C+      K   V   DG WG WS + TC  T  
Sbjct: 553 CRTQHTPWADGTEC-------EPGKHCKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCG 605

Query: 583 ---RSRTRECNNPAPQRGGKRCEGEKRQEEDCTFSIMENNGQPCIND-----DEEMKEVD 634
              ++  RECN P P+ GGK C G + + + C       N +PC+       DE+    D
Sbjct: 606 GGIKTAIRECNRPEPKNGGKYCVGRRMKFKSC-------NTEPCLKQKRDFRDEQCAHFD 658

Query: 635 LPEIEADSGCPQP--VPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGT 691
                 +   P    VP  +G +  ++         ++ C     T  YQ    + DGT
Sbjct: 659 GKHFNINGLLPNVRWVPKYSGILMKDR--------CKLFCRVAGNTAYYQLRDRVIDGT 709



 Score = 46.2 bits (108), Expect = 1e-04
 Identities = 35/132 (26%), Positives = 50/132 (37%), Gaps = 20/132 (15%)

Query: 24   CDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENF----CEQICSKQETRECNWQRCP 79
            C  +A+  W  C+K C  G   R R +V  +   E F    CE +    +  +CN   CP
Sbjct: 1383 CPQWAYGNWGECTKLCGGGI--RTRLVVCQRSNGERFPDLSCEILDKPPDREQCNTHACP 1440

Query: 80   INCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGGQPCTAPLVAFQPCIPSKLCKIEEAD 139
             +      GPWS C     +  K R+V   ++ G              + S  CK   A 
Sbjct: 1441 HDAAWST-GPWSSCSVSCGRGHKQRNVYCMAKDGSH------------LESDYCK-HLAK 1486

Query: 140  CKNKFRCDSGRC 151
                 +C  GRC
Sbjct: 1487 PHGHRKCRGGRC 1498



 Score = 44.7 bits (104), Expect = 4e-04
 Identities = 24/86 (27%), Positives = 36/86 (41%), Gaps = 4/86 (4%)

Query: 24   CDHYAWTQWTSCSKTCNSGTQSRH--RQIVVDKYYQENFCEQICSKQETRECNWQRCPIN 81
            C  +    W+ CS +C  G Q RH   QI   K  +E  C      +  R+C   RCP+ 
Sbjct: 1498 CPKWKAGAWSQCSVSCGRGVQQRHVGCQIGTHKIARETECNPYTRPESERDCQGPRCPLY 1557

Query: 82   CLLGDFGPWSDCDPCIEKQSKVRSVL 107
                +   W +C     + S+ R V+
Sbjct: 1558 TWRAE--EWQECTKTCGEGSRYRKVV 1581



 Score = 41.6 bits (96), Expect = 0.003
 Identities = 47/174 (27%), Positives = 67/174 (38%), Gaps = 31/174 (17%)

Query: 22   CFCDHYAWTQWTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETRECNWQRC-PI 80
            C    + ++ WT CSK+C+ GTQ R R I V+    +   +  C+ QE  +   QRC   
Sbjct: 996  CNTGGWRYSAWTECSKSCDGGTQ-RRRAICVNT-RNDVLDDSKCTHQE--KVTIQRCSEF 1051

Query: 81   NCLLGDFGPWSDCDPCIEKQSKVRSVLRPSQFGG-----------------QPCTAPLVA 123
             C     G WS+C     K  K R V    QFG                  Q C  P  A
Sbjct: 1052 PCPQWKSGDWSECLVTCGKGHKHRQVW--CQFGEDRLNDRMCDPETKPTSMQTCQQPECA 1109

Query: 124  FQPCIPSKLCKIEEADCKNKFRCDSGRC-IARKLECNGENDCG---DNSDERDC 173
                 P   C +    C   ++  + +C I   +    +NDC      +D +DC
Sbjct: 1110 SWQAGPWGQCSV---TCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDC 1160



 Score = 38.1 bits (87), Expect = 0.039
 Identities = 28/89 (31%), Positives = 39/89 (43%), Gaps = 11/89 (12%)

Query: 24   CDHYAWT--QWTSCSKTCNSGTQSRHRQIV-VDKYYQENF---CEQICSKQETRECNWQR 77
            C  Y W   +W  C+KTC  G  SR+R++V VD    E     C+      +   C+ Q 
Sbjct: 1554 CPLYTWRAEEWQECTKTCGEG--SRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQP 1611

Query: 78   CPINCLLGDFGPWSDCDPCIEKQSKVRSV 106
            C    + G+   WS+C     K  K R V
Sbjct: 1612 CEYVWITGE---WSECSVTCGKGYKQRLV 1637



 Score = 37.7 bits (86), Expect = 0.050
 Identities = 21/75 (28%), Positives = 34/75 (45%), Gaps = 9/75 (12%)

Query: 24   CDH-YAWTQ--WTSCSKTCNSGTQSRHRQIVV--DKYYQENFCEQICSKQETRECNWQRC 78
            C H  AW+   W+SCS +C  G + R+   +     + + ++C+ +      R+C   RC
Sbjct: 1439 CPHDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRC 1498

Query: 79   PINCLLGDFGPWSDC 93
            P        G WS C
Sbjct: 1499 P----KWKAGAWSQC 1509



 Score = 36.2 bits (82), Expect = 0.15
 Identities = 19/62 (30%), Positives = 25/62 (40%), Gaps = 4/62 (6%)

Query: 32   WTSCSKTCNSGTQSRHRQIVVDKYYQENFCEQICSKQETRECNWQRCPINCLLGDFGPWS 91
            W +CS TC  G+Q R      +  Y  N C +     E R C    CP       +G W 
Sbjct: 1337 WGACSSTCAGGSQRRVVVCQDENGYTANDCVERIKPDEQRACESGPCP----QWAYGNWG 1392

Query: 92   DC 93
            +C
Sbjct: 1393 EC 1394



 Score = 33.9 bits (76), Expect = 0.73
 Identities = 16/58 (27%), Positives = 25/58 (43%), Gaps = 2/58 (3%)

Query: 24   CDHYAWTQWTSCSKTCNSGTQSRHRQIV--VDKYYQENFCEQICSKQETRECNWQRCP 79
            C  +    W+SCS TC  G  +R    V   D     + C+Q    +  ++C+   CP
Sbjct: 1239 CGQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIPETDQDCSMSPCP 1296


>gi|110611237 coagulation factor XIII B subunit precursor [Homo
           sapiens]
          Length = 661

 Score = 57.8 bits (138), Expect = 5e-08
 Identities = 36/126 (28%), Positives = 53/126 (42%), Gaps = 9/126 (7%)

Query: 644 CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVEC---- 699
           CP P  P N  I+     Y  GE V I C   FE  G    RC  DG W +   +C    
Sbjct: 274 CPPPPLPINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRC-EDGKWTEPP-KCIEGQ 331

Query: 700 QRTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGNSWTPP---IS 756
           ++  C +P   E        ++Y  G+ +   C  G+++ G +  TC    WT P   + 
Sbjct: 332 EKVACEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITCNRGKWTLPPECVE 391

Query: 757 NSLTCE 762
           N+  C+
Sbjct: 392 NNENCK 397



 Score = 50.8 bits (120), Expect = 6e-06
 Identities = 29/105 (27%), Positives = 43/105 (40%), Gaps = 1/105 (0%)

Query: 651 ENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDV-ECQRTECIKPVV 709
           ENG+    KQ Y  G+ V+  C   +   G    +C   G + +  V E +R  C  P +
Sbjct: 220 ENGYFHPVKQTYEEGDVVQFFCHENYYLSGSDLIQCYNFGWYPESPVCEGRRNRCPPPPL 279

Query: 710 QEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGNSWTPP 754
                I      YR GE + + C   F + G +   C+   WT P
Sbjct: 280 PINSKIQTHSTTYRHGEIVHIECELNFEIHGSAEIRCEDGKWTEP 324



 Score = 47.4 bits (111), Expect = 6e-05
 Identities = 32/133 (24%), Positives = 57/133 (42%), Gaps = 9/133 (6%)

Query: 636 PEIEADSGCPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVG---YQYFRCLPDGTW 692
           PE      C +P    NG+I + K LY + E++   C +G++T G    +  +CL DG  
Sbjct: 83  PEPRCFKKCTKP-DLSNGYISDVKLLYKIQENMRYGCASGYKTTGGKDEEVVQCLSDGWS 141

Query: 693 RQGDVECQRTECIKPVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSR---YTCQGN 749
            Q     +   C+ P +      +  Q+ +++ + ++  C  G+  AG  +     C   
Sbjct: 142 SQPTCRKEHETCLAPELYNG-NYSTTQKTFKVKDKVQYECATGYYTAGGKKTEEVECLTY 200

Query: 750 SWT-PPISNSLTC 761
            W+  P    L C
Sbjct: 201 GWSLTPKCTKLKC 213



 Score = 41.2 bits (95), Expect = 0.005
 Identities = 28/113 (24%), Positives = 43/113 (38%), Gaps = 3/113 (2%)

Query: 644 CPQPVPPENGFIRNEKQLYLVGEDVEISCLTGFETVGYQYFRCLPDGTWRQGDVECQRTE 703
           C +P   ENG      ++Y  G+ V  +C +G+   G     C   G W       +  E
Sbjct: 336 CEEPPFIENGAANLHSKIYYNGDKVTYACKSGYLLHGSNEITC-NRGKWTLPPECVENNE 394

Query: 704 CIK--PVVQEVLTITPFQRLYRIGESIELTCPKGFVVAGPSRYTCQGNSWTPP 754
             K  PVV            Y  G S+E  C + +++ G     C+   W+ P
Sbjct: 395 NCKHPPVVMNGAVADGILASYATGSSVEYRCNEYYLLRGSKISRCEQGKWSSP 447


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.318    0.134    0.426 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 41,181,901
Number of Sequences: 37866
Number of extensions: 2092519
Number of successful extensions: 7047
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 185
Number of HSP's successfully gapped in prelim test: 114
Number of HSP's that attempted gapping in prelim test: 4996
Number of HSP's gapped (non-prelim): 1730
length of query: 934
length of database: 18,247,518
effective HSP length: 112
effective length of query: 822
effective length of database: 14,006,526
effective search space: 11513364372
effective search space used: 11513364372
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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