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Search of human proteins with 16933525
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|16933525 unc5C [Homo sapiens]
(931 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|16933525 unc5C [Homo sapiens] 1909 0.0
gi|32261318 unc-5 homolog B [Homo sapiens] 1209 0.0
gi|209977117 unc-5 homolog D [Homo sapiens] 930 0.0
gi|62243567 netrin receptor Unc5h1 [Homo sapiens] 885 0.0
gi|118572606 hemicentin 1 [Homo sapiens] 126 1e-28
gi|40317628 thrombospondin 2 precursor [Homo sapiens] 109 1e-23
gi|147904700 semaphorin 5A [Homo sapiens] 107 5e-23
gi|27734865 unc-5 homolog C-like [Homo sapiens] 105 1e-22
gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens] 103 6e-22
gi|91982767 semaphorin 5B isoform 1 [Homo sapiens] 103 1e-21
gi|40317626 thrombospondin 1 precursor [Homo sapiens] 101 3e-21
gi|111118994 brain-specific angiogenesis inhibitor 1 precursor [... 101 3e-21
gi|4505737 complement factor properdin precursor [Homo sapiens] 95 3e-19
gi|223671861 complement factor properdin precursor [Homo sapiens] 95 3e-19
gi|115387099 brain-specific angiogenesis inhibitor 2 [Homo sapiens] 92 2e-18
gi|134031945 SCO-spondin [Homo sapiens] 91 7e-18
gi|193083163 roundabout, axon guidance receptor, homolog 2 isofo... 84 5e-16
gi|61888896 roundabout, axon guidance receptor, homolog 2 isofor... 82 2e-15
gi|4506569 roundabout 1 isoform a [Homo sapiens] 80 1e-14
gi|116875765 tight junction protein 1 isoform b [Homo sapiens] 79 3e-14
gi|116875767 tight junction protein 1 isoform a [Homo sapiens] 79 3e-14
gi|224994173 roundabout 1 isoform d [Homo sapiens] 78 3e-14
gi|224994171 roundabout 1 isoform c [Homo sapiens] 78 3e-14
gi|19743806 roundabout 1 isoform b [Homo sapiens] 78 3e-14
gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo ... 78 3e-14
gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo ... 78 3e-14
gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo ... 77 1e-13
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 65 4e-10
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 63 1e-09
gi|4557389 complement component 8, alpha polypeptide precursor [... 62 2e-09
>gi|16933525 unc5C [Homo sapiens]
Length = 931
Score = 1909 bits (4946), Expect = 0.0
Identities = 931/931 (100%), Positives = 931/931 (100%)
Query: 1 MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEP 60
MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEP
Sbjct: 1 MRKGLRATAARCGLGLGYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEP 60
Query: 61 LPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVR 120
LPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVR
Sbjct: 61 LPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVR 120
Query: 121 EVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSL 180
EVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSL
Sbjct: 121 EVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSL 180
Query: 181 EQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCV 240
EQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCV
Sbjct: 181 EQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCV 240
Query: 241 AKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCE 300
AKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCE
Sbjct: 241 AKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCE 300
Query: 301 GQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSK 360
GQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSK
Sbjct: 301 GQSVQKIACTTLCPVDGRWTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSK 360
Query: 361 NCTDGLCMQTAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALN 420
NCTDGLCMQTAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALN
Sbjct: 361 NCTDGLCMQTAPDSDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALN 420
Query: 421 GGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIK 480
GGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIK
Sbjct: 421 GGFQPVNIKAARQDLLAVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIK 480
Query: 481 VYNTSGAVTPQDDLSEFTSKLSPQMTQSLLENEALSLKNQSLARQTDPSCTAFGSFNSLG 540
VYNTSGAVTPQDDLSEFTSKLSPQMTQSLLENEALSLKNQSLARQTDPSCTAFGSFNSLG
Sbjct: 481 VYNTSGAVTPQDDLSEFTSKLSPQMTQSLLENEALSLKNQSLARQTDPSCTAFGSFNSLG 540
Query: 541 GHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMDDSQTLLTPVVSCGPPGAL 600
GHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMDDSQTLLTPVVSCGPPGAL
Sbjct: 541 GHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMDDSQTLLTPVVSCGPPGAL 600
Query: 601 LTRPVVLTMHHCADPNTEDWKILLKNQAAQGQWEDVVVVGEENFTTPCYIKLDAEACHIL 660
LTRPVVLTMHHCADPNTEDWKILLKNQAAQGQWEDVVVVGEENFTTPCYIKLDAEACHIL
Sbjct: 601 LTRPVVLTMHHCADPNTEDWKILLKNQAAQGQWEDVVVVGEENFTTPCYIKLDAEACHIL 660
Query: 661 TENLSTYALVGHSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEILHLERQ 720
TENLSTYALVGHSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEILHLERQ
Sbjct: 661 TENLSTYALVGHSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEILHLERQ 720
Query: 721 TGGQLLEEPKALHFKGSTHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHVWSGSQRNLHCT 780
TGGQLLEEPKALHFKGSTHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHVWSGSQRNLHCT
Sbjct: 721 TGGQLLEEPKALHFKGSTHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHVWSGSQRNLHCT 780
Query: 781 FTLERFSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPANTITTVTGPS 840
FTLERFSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPANTITTVTGPS
Sbjct: 781 FTLERFSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPANTITTVTGPS 840
Query: 841 AFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQN 900
AFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQN
Sbjct: 841 AFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQN 900
Query: 901 FPDGNLSMLAAVLEEMGRHETVVSLAAEGQY 931
FPDGNLSMLAAVLEEMGRHETVVSLAAEGQY
Sbjct: 901 FPDGNLSMLAAVLEEMGRHETVVSLAAEGQY 931
>gi|32261318 unc-5 homolog B [Homo sapiens]
Length = 945
Score = 1209 bits (3129), Expect = 0.0
Identities = 597/941 (63%), Positives = 717/941 (76%), Gaps = 34/941 (3%)
Query: 17 GYLLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKN 76
G LL L+L LS +GT S ++ LP++FPS P EPLP+FL EP++AYIVKN
Sbjct: 9 GALLLALLLCWDPRLSQAGTDSGSE------VLPDSFPSAPAEPLPYFLQEPQDAYIVKN 62
Query: 77 KPVNLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSIEISRQQVEELFG 136
KPV L C+A PATQIYFKCN EWV Q DH+ E +DE +GL VREV IE+SRQQVEELFG
Sbjct: 63 KPVELRCRAFPATQIYFKCNGEWVSQNDHVTQEGLDEATGLRVREVQIEVSRQQVEELFG 122
Query: 137 PEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPV 196
EDYWCQCVAWSSAGTTKSR+AYVRIAYLRK F+QEPLGKEV L+ EVLLQCRPPEG+PV
Sbjct: 123 LEDYWCQCVAWSSAGTTKSRRAYVRIAYLRKNFDQEPLGKEVPLDHEVLLQCRPPEGVPV 182
Query: 197 AEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVI 256
AEVEWLKNED+IDP +D NF +TIDHNLII+QARLSDTANYTCVAKNIVAKR+STTATVI
Sbjct: 183 AEVEWLKNEDVIDPTQDTNFLLTIDHNLIIRQARLSDTANYTCVAKNIVAKRRSTTATVI 242
Query: 257 VYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVD 316
VYVNGGWS+W EWS C++RCGRG+QKRTRTCTNPAPLNGGAFCEGQ+ QK ACTT+CPVD
Sbjct: 243 VYVNGGWSSWAEWSPCSNRCGRGWQKRTRTCTNPAPLNGGAFCEGQAFQKTACTTICPVD 302
Query: 317 GRWTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQ---TAPD 373
G WT WSKWS C TEC HWR REC AP P+NGG+DC G +L SKNCTDGLCMQ T D
Sbjct: 303 GAWTEWSKWSACSTECAHWRSRECMAPPPQNGGRDCSGTLLDSKNCTDGLCMQNKKTLSD 362
Query: 374 --------SDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSS-ALNGGFQ 424
S D ALY G+V+A+ V +AI + V + VYR+N RDF++DI DSS AL GGF
Sbjct: 363 PNSHLLEASGDAALYAGLVVAIFVVVAILMAVGVVVYRRNCRDFDTDITDSSAALTGGFH 422
Query: 425 PVNIKAAR---QDLL--AVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKI 479
PVN K AR LL +VPPDLT++A +YRGPVYAL D +DKIPMTNSP+LDPLP+LK+
Sbjct: 423 PVNFKTARPSNPQLLHPSVPPDLTASAGIYRGPVYALQDSTDKIPMTNSPLLDPLPSLKV 482
Query: 480 KVY--NTSGAVTPQDDLSEFTSKLSPQMTQS--LLENEALSLKNQSLARQ------TDPS 529
KVY +T+G+ D ++ L P S + L L++ SL Q DP
Sbjct: 483 KVYSSSTTGSGPGLADGADLLGVLPPGTYPSDFARDTHFLHLRSASLGSQQLLGLPRDPG 542
Query: 530 CTAFGSFNSLGGHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMDDSQTLLT 589
+ G+F LGG L +P +GVSLL+P GAIPQG+ YEMY+ +++ E+ P + +QT+L+
Sbjct: 543 SSVSGTFGCLGGRLSIPGTGVSLLVPNGAIPQGKFYEMYLLINKAESTLPLSEGTQTVLS 602
Query: 590 PVVSCGPPGALLTRPVVLTMHHCADPNTEDWKILLKNQAAQGQWEDVVVVGEENFTTPCY 649
P V+CGP G LL RPV+LTM HCA+ + DW LK QA QG WE+VV + EE TPCY
Sbjct: 603 PSVTCGPTGLLLCRPVILTMPHCAEVSARDWIFQLKTQAHQGHWEEVVTLDEETLNTPCY 662
Query: 650 IKLDAEACHILTENLSTYALVGHSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQD 709
+L+ ACHIL + L TY G S +++A KRL+LA+F P C+SLEYS+RVYCL+DT
Sbjct: 663 CQLEPRACHILLDQLGTYVFTGESYSRSAVKRLQLAVFAPALCTSLEYSLRVYCLEDTPV 722
Query: 710 ALKEILHLERQTGGQLLEEPKALHFKGSTHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHV 769
ALKE+L LER GG L+EEPK L FK S HNLRLS+HD+ H+ W+SKLLAKYQEIPFYH+
Sbjct: 723 ALKEVLELERTLGGYLVEEPKPLMFKDSYHNLRLSLHDLPHAHWRSKLLAKYQEIPFYHI 782
Query: 770 WSGSQRNLHCTFTLERFSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTG-IDLPLLD 828
WSGSQ+ LHCTFTLER SL + EL CK+CVRQVEGEGQIFQL+ T++E P G +D
Sbjct: 783 WSGSQKALHCTFTLERHSLASTELTCKICVRQVEGEGQIFQLHTTLAETPAGSLDTLCSA 842
Query: 829 PANTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSP 888
P +T+TT GP AF IPL IRQK+C+SLDAP +RG+DWRMLA KL++DRYLNYFATK+SP
Sbjct: 843 PGSTVTTQLGPYAFKIPLSIRQKICNSLDAPNSRGNDWRMLAQKLSMDRYLNYFATKASP 902
Query: 889 TGVILDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEG 929
TGVILDLWEA DG+L+ LA+ LEEMG+ E +V++A +G
Sbjct: 903 TGVILDLWEALQQDDGDLNSLASALEEMGKSEMLVAVATDG 943
>gi|209977117 unc-5 homolog D [Homo sapiens]
Length = 953
Score = 930 bits (2404), Expect = 0.0
Identities = 470/938 (50%), Positives = 630/938 (67%), Gaps = 48/938 (5%)
Query: 25 LPALALLSASGTGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCK 84
LP L L + +AA+ D LPE+ PS P LPHF+ EP++AYI+K+ P+ L CK
Sbjct: 18 LPWLGLCFWAAGTAAARGTDNGEALPESIPS-APGTLPHFIEEPDDAYIIKSNPIALRCK 76
Query: 85 ASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQC 144
A PA QI+FKCN EWVHQ +H+ +E +DE+SGL VREV I ++RQQVE+ GPEDYWCQC
Sbjct: 77 ARPAMQIFFKCNGEWVHQNEHVSEETLDESSGLKVREVFINVTRQQVEDFHGPEDYWCQC 136
Query: 145 VAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKN 204
VAWS GT+KSRKA VRIAYLRK FEQ+P G+EV +E ++L CRPPEG+P AEVEWLKN
Sbjct: 137 VAWSHLGTSKSRKASVRIAYLRKNFEQDPQGREVPIEGMIVLHCRPPEGVPAAEVEWLKN 196
Query: 205 EDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWS 264
E+ ID +D N DHNLII+QARLSD+ NYTC+A NIVAKR+S +ATV+VYVNGGWS
Sbjct: 197 EEPIDSEQDENIDTRADHNLIIRQARLSDSGNYTCMAANIVAKRRSLSATVVVYVNGGWS 256
Query: 265 TWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWSK 324
+WTEWS CN RCGRG+QKR+RTCTNPAPLNGGAFCEG SVQKI CT+LCPVDG W WS+
Sbjct: 257 SWTEWSACNVRCGRGWQKRSRTCTNPAPLNGGAFCEGMSVQKITCTSLCPVDGSWEVWSE 316
Query: 325 WSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCM-----------QTAPD 373
WS C EC H R RECTAP P+NGGK C+GL +S+NCTDGLC+ Q+ +
Sbjct: 317 WSVCSPECEHLRIRECTAPPPRNGGKFCEGLSQESENCTDGLCILDKKPLHEIKPQSIEN 376
Query: 374 SDDVALYVGIVIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQ 433
+ D+ALY G+ AV+ + V+ + +YR++ D+ D+IDSSAL GGFQ N K RQ
Sbjct: 377 ASDIALYSGLGAAVVAVAVL--VIGVTLYRRSQSDYGVDVIDSSALTGGFQTFNFKTVRQ 434
Query: 434 --DLL---AVPPDLTSAAAMYRGPVYALHDVSDKIPMTNSPILDPLPNLKIKVYNTSGAV 488
LL A+ PDLT + Y GP+ L D DK MT S + +PL ++K+KV ++
Sbjct: 435 GNSLLLNSAMQPDLT-VSRTYSGPI-CLQDPLDKELMTESSLFNPLSDIKVKVQSSFMVS 492
Query: 489 TPQDDLSEFTSK----------------LSPQMTQSLLENEALSLKNQSLARQTDPSCTA 532
+ +E+ K + P+ ++N + SL ++ R T
Sbjct: 493 LGVSERAEYHGKNHSRTFPHGNNHSFSTMHPRNKMPYIQNLS-SLPTRTELRTT------ 545
Query: 533 FGSFNSLGGHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMDDSQTLLTPVV 592
G F LGG L++PN+GVSLLIP GAIP+ +E+Y+++++ E D S+ LL+P V
Sbjct: 546 -GVFGHLGGRLVMPNTGVSLLIPHGAIPEENSWEIYMSINQGEPSL-QSDGSEVLLSPEV 603
Query: 593 SCGPPGALLTRPVVLTMHHCADPNTEDWKILLKNQAAQGQWEDVVVVGEENFTTPCYIKL 652
+CGPP ++T P LT+ HCAD ++E W I LK + QG+WE+V+ V +E +T CY L
Sbjct: 604 TCGPPDMIVTTPFALTIPHCADVSSEHWNIHLKKRTQQGKWEEVMSVEDE--STSCYCLL 661
Query: 653 DAEACHILTENLSTYALVGHSTTKAAAKRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALK 712
D ACH+L ++ TYAL G T A K+LK+A+FG + C+SL+Y++RVYC+D+T A +
Sbjct: 662 DPFACHVLLDSFGTYALTGEPITDCAVKQLKVAVFGCMSCNSLDYNLRVYCVDNTPCAFQ 721
Query: 713 EILHLERQTGGQLLEEPKALHFKGSTHNLRLSIHDIAHSLWKSKLLAKYQEIPFYHVWSG 772
E++ ER GGQLLEEPK LHFKG+T +L++S+ DI LW+ K QE+PF VW
Sbjct: 722 EVVSDERHQGGQLLEEPKLLHFKGNTFSLQISVLDIPPFLWRIKPFTACQEVPFSRVWCS 781
Query: 773 SQRNLHCTFTLERFSLNTVELVCKLCVRQVEGEGQIFQLNCTVSEEPTGIDLPLLDPANT 832
+++ LHC F+LER++ T +L CK+C+RQ++G QI Q+ ++ E +T
Sbjct: 782 NRQPLHCAFSLERYTPTTTQLSCKICIRQLKGHEQILQVQTSILESERETITFFAQEDST 841
Query: 833 ITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVI 892
TGP AF IP IRQ++C++ D P +G DW+MLA K +++R L+YFAT+SSP+ VI
Sbjct: 842 FPAQTGPKAFKIPYSIRQRICATFDTPNAKGKDWQMLAQKNSINRNLSYFATQSSPSAVI 901
Query: 893 LDLWEAQNFPDGNLSMLAAVLEEMGRHETVVSLAAEGQ 930
L+LWEA++ DG+L LA LEE+GR T +S +E Q
Sbjct: 902 LNLWEARHQHDGDLDSLACALEEIGRTHTKLSNISESQ 939
>gi|62243567 netrin receptor Unc5h1 [Homo sapiens]
Length = 842
Score = 885 bits (2288), Expect = 0.0
Identities = 459/911 (50%), Positives = 606/911 (66%), Gaps = 84/911 (9%)
Query: 26 PALA--LLSASGTGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYC 83
PAL +L+A GS AQ + P P+ LPHFL+EPE+ YIVKNKPV L C
Sbjct: 9 PALLGIVLAAWLRGSGAQQSA---TVANPVPGANPDLLPHFLVEPEDVYIVKNKPVLLVC 65
Query: 84 KASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSIEISRQQVEELFGPEDYWCQ 143
KA PATQI+FKCN EWV Q DH+++ D +SGL EV I +SRQQVE++FG E+YWCQ
Sbjct: 66 KAVPATQIFFKCNGEWVRQVDHVIERSTDGSSGLPTMEVRINVSRQQVEKVFGLEEYWCQ 125
Query: 144 CVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLK 203
CVAWSS+GTTKS+KAY+RIAYLRK FEQEPL KEVSLEQ ++L CRPPEGIP AEVEWL+
Sbjct: 126 CVAWSSSGTTKSQKAYIRIAYLRKNFEQEPLAKEVSLEQGIVLPCRPPEGIPPAEVEWLR 185
Query: 204 NEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGW 263
NED++DP D N YIT +H+L+++QARL+DTANYTCVAKNIVA+R+S +A VIVYV+G W
Sbjct: 186 NEDLVDPSLDPNVYITREHSLVVRQARLADTANYTCVAKNIVARRRSASAAVIVYVDGSW 245
Query: 264 STWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWS 323
S W++WS C C R+R C++PAP NGG C+G + CT+
Sbjct: 246 SPWSKWSACGLDCTHW---RSRECSDPAPRNGGEECQGTDLDTRNCTS------------ 290
Query: 324 KWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQTAPDSDDVALYVGI 383
C H TA +DVALYVG+
Sbjct: 291 ------DLCVH-----------------------------------TASGPEDVALYVGL 309
Query: 384 VIAVIVCLAISVVVALFVYRKNHRDFESDIIDSSALNGGFQPVNIKAARQD---LLAVPP 440
IAV VCL + ++V + VY + +SD+ DSS L GFQPV+IK ++ D LL + P
Sbjct: 310 -IAVAVCLVLLLLVLILVYCRKKEGLDSDVADSSILTSGFQPVSIKPSKADNPHLLTIQP 368
Query: 441 DLTSAAAMYRGPVYALHD-VSDKIPMTNSPILDPLPNLKIKVYNTSGAVTPQDDLSEFTS 499
DL++ Y+G + D S K +TN +L PL + ++++S P + EF S
Sbjct: 369 DLSTTTTTYQGSLCPRQDGPSPKFQLTNGHLLSPLGGGRHTLHHSS----PTSEAEEFVS 424
Query: 500 KLSPQMTQSLLENEALSLKNQSLARQTDPSCTAFGSFNSLGGHLIVPNSGVSLLIPAGAI 559
+LS TQ+ +SL R T S +G+FN LGG L++PN+G+SLLIP AI
Sbjct: 425 RLS---TQNYF---------RSLPRGT--SNMTYGTFNFLGGRLMIPNTGISLLIPPDAI 470
Query: 560 PQGRVYEMYVTVHRKETMRPPMDDSQTLLTPVVSCGPPGALLTRPVVLTMHHCADPNTED 619
P+G++YE+Y+T+H+ E +R P+ QTLL+P+VSCGPPG LLTRPV+L M HC +P+ +
Sbjct: 471 PRGKIYEIYLTLHKPEDVRLPLAGCQTLLSPIVSCGPPGVLLTRPVILAMDHCGEPSPDS 530
Query: 620 WKILLKNQAAQGQWEDVVVVGEENFTTPCYIKLDAEACHILTENLSTYALVGHSTTKAAA 679
W + LK Q+ +G WEDV+ +GEE + Y +L+A AC++ TE L +ALVG + + AAA
Sbjct: 531 WSLRLKKQSCEGSWEDVLHLGEEAPSHLYYCQLEASACYVFTEQLGRFALVGEALSVAAA 590
Query: 680 KRLKLAIFGPLCCSSLEYSIRVYCLDDTQDALKEILHLERQTGGQLLEEPKALHFKGSTH 739
KRLKL +F P+ C+SLEY+IRVYCL DT DALKE++ LE+Q GGQL++EP+ LHFK S H
Sbjct: 591 KRLKLLLFAPVACTSLEYNIRVYCLHDTHDALKEVVQLEKQLGGQLIQEPRVLHFKDSYH 650
Query: 740 NLRLSIHDIAHSLWKSKLLAKYQEIPFYHVWSGSQRNLHCTFTLERFSLNTVELVCKLCV 799
NLRLSIHD+ SLWKSKLL YQEIPFYH+W+G+QR LHCTFTLER S +T +L CKL V
Sbjct: 651 NLRLSIHDVPSSLWKSKLLVSYQEIPFYHIWNGTQRYLHCTFTLERVSPSTSDLACKLWV 710
Query: 800 RQVEGEGQIFQLNCTVSEEPTGIDLPLLDPANTITTVTGPSAFSIPLPIRQKLCSSLDAP 859
QVEG+GQ F +N ++++ +L L+ + + GPSAF IP IRQK+ SSLD P
Sbjct: 711 WQVEGDGQSFSINFNITKDTRFAELLALESEAGVPALVGPSAFKIPFLIRQKIISSLDPP 770
Query: 860 QTRGHDWRMLAHKLNLDRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEMGRH 919
RG DWR LA KL+LD +L++FA+K SPT +IL+LWEA++FP+GNLS LAA + +G+
Sbjct: 771 CRRGADWRTLAQKLHLDSHLSFFASKPSPTAMILNLWEARHFPNGNLSQLAAAVAGLGQP 830
Query: 920 ETVVSLAAEGQ 930
+ + +E +
Sbjct: 831 DAGLFTVSEAE 841
>gi|118572606 hemicentin 1 [Homo sapiens]
Length = 5635
Score = 126 bits (316), Expect = 1e-28
Identities = 65/200 (32%), Positives = 101/200 (50%), Gaps = 8/200 (4%)
Query: 172 EPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARL 231
EP+ ++ +++L C+ G P + W + I D + +++L I A+
Sbjct: 4445 EPVETVINAGGKIILNCQAT-GEPQPTITWSRQGHSIS--WDDRVNVLSNNSLYIADAQK 4501
Query: 232 SDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPA 291
DT+ + CVA+N++ VIV V+GG+S W+ W C+ CG+G QKR+R C P
Sbjct: 4502 EDTSEFECVARNLMGS-VLVRVPVIVQVHGGFSQWSAWRACSVTCGKGIQKRSRLCNQPL 4560
Query: 292 PLNGGAFCEGQSVQKIACTTL-CPVDGRWTPWSKWSTCGTEC---THWRRRECTAPAPKN 347
P NGG C+G ++ C CPVDG W+ WS W C C R R C P+ ++
Sbjct: 4561 PANGGKPCQGSDLEMRNCQNKPCPVDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQH 4620
Query: 348 GGKDCDGLVLQSKNCTDGLC 367
GG+ C+G ++ C C
Sbjct: 4621 GGRPCEGNAVEIIMCNIRPC 4640
Score = 111 bits (278), Expect = 3e-24
Identities = 51/113 (45%), Positives = 60/113 (53%), Gaps = 4/113 (3%)
Query: 259 VNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTL-CPVDG 317
V+G WS W+ W C CGRG Q RTRTC NP+ +GG CEG +V+ I C CPV G
Sbjct: 4585 VDGSWSEWSLWEECTRSCGRGNQTRTRTCNNPSVQHGGRPCEGNAVEIIMCNIRPCPVHG 4644
Query: 318 RWTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLC 367
W+ W W TC C T R R C P P GG CDG Q + C + C
Sbjct: 4645 AWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERNC 4697
Score = 111 bits (278), Expect = 3e-24
Identities = 45/113 (39%), Positives = 59/113 (52%), Gaps = 4/113 (3%)
Query: 259 VNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTL-CPVDG 317
V+G WS W W C+ CG+G Q R R C NP P GG++C+G Q C CP+ G
Sbjct: 4642 VHGAWSAWQPWGTCSESCGKGTQTRARLCNNPPPAFGGSYCDGAETQMQVCNERNCPIHG 4701
Query: 318 RWTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLC 367
+W W+ WS C C R R C+ P P+ GG+ C+G +QS C C
Sbjct: 4702 KWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSDVQSDFCNSDPC 4754
Score = 111 bits (277), Expect = 4e-24
Identities = 48/113 (42%), Positives = 61/113 (53%), Gaps = 4/113 (3%)
Query: 259 VNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTT-LCPVDG 317
++G W+TW WS C+ CG G ++RTR C++P P GG CEG VQ C + CP G
Sbjct: 4699 IHGKWATWASWSACSVSCGGGARQRTRGCSDPVPQYGGRKCEGSDVQSDFCNSDPCPTHG 4758
Query: 318 RWTPWSKWSTCGTECTHW---RRRECTAPAPKNGGKDCDGLVLQSKNCTDGLC 367
W+PWS W TC C R R C P P NGG+ C G Q + C +C
Sbjct: 4759 NWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQRCNTDMC 4811
Score = 102 bits (255), Expect = 1e-21
Identities = 46/112 (41%), Positives = 53/112 (47%), Gaps = 4/112 (3%)
Query: 260 NGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTT-LCPVDGR 318
+G WS W+ W C+ C G +R RTC NP P NGG C G Q C T +CPVDG
Sbjct: 4757 HGNWSPWSGWGTCSRTCNGGQMRRYRTCDNPPPSNGGRACGGPDSQIQRCNTDMCPVDGS 4816
Query: 319 WTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLC 367
W W WS C C R+R C P P GG+ C G Q C C
Sbjct: 4817 WGSWHSWSQCSASCGGGEKTRKRLCDHPVPVKGGRPCPGDTTQVTRCNVQAC 4868
Score = 58.2 bits (139), Expect = 4e-08
Identities = 23/57 (40%), Positives = 31/57 (54%), Gaps = 1/57 (1%)
Query: 259 VNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTT-LCP 314
V+G W +W WS C++ CG G + R R C +P P+ GG C G + Q C CP
Sbjct: 4813 VDGSWGSWHSWSQCSASCGGGEKTRKRLCDHPVPVKGGRPCPGDTTQVTRCNVQACP 4869
Score = 55.1 bits (131), Expect = 3e-07
Identities = 85/357 (23%), Positives = 132/357 (36%), Gaps = 82/357 (22%)
Query: 61 LPHFLIEPEEAYIVKNKPVNLYCKAS--PATQIYFKCNSEWVHQKDHIVDERVDETSG-- 116
LP F P + + K + + L CKA+ P ++ + N+ +I+ D +G
Sbjct: 4259 LPTFTELPGDVSLNKGEQLRLSCKATGIPLPKLTWTFNN-------NIIPAHFDSVNGHS 4311
Query: 117 -LIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRK--TFEQ-- 171
L++ VS E S V C A +S G K+ + Y+++ F+
Sbjct: 4312 ELVIERVSKEDSGTYV------------CTAENSVGFVKA----IGFVYVKEPPVFKGDY 4355
Query: 172 -----EPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLII 226
EPLG L EV +G P ++W N +D + +L I
Sbjct: 4356 PSNWIEPLGGNAILNCEV-------KGDPTPTIQW--NRKGVDIEISHRIRQLGNGSLAI 4406
Query: 227 KQARLSDTANYTCVAKN---IVAKRKSTT------------ATVI-----VYVNGGWSTW 266
D +YTCVA N +V + S T TVI + +N +
Sbjct: 4407 YGTVNEDAGDYTCVATNEAGVVERSMSLTLQSPPIITLEPVETVINAGGKIILNCQATGE 4466
Query: 267 TEWSVCNSRCGR--GYQKRTRTCTNPAPLNGGAFCEGQSVQK-----------IACTTLC 313
+ ++ SR G + R +N + A E S + + +
Sbjct: 4467 PQPTITWSRQGHSISWDDRVNVLSNNSLYIADAQKEDTSEFECVARNLMGSVLVRVPVIV 4526
Query: 314 PVDGRWTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLC 367
V G ++ WS W C C R R C P P NGGK C G L+ +NC + C
Sbjct: 4527 QVHGGFSQWSAWRACSVTCGKGIQKRSRLCNQPLPANGGKPCQGSDLEMRNCQNKPC 4583
Score = 54.3 bits (129), Expect = 5e-07
Identities = 62/198 (31%), Positives = 89/198 (44%), Gaps = 25/198 (12%)
Query: 67 EPEEAYIVKNKPVNLYCKAS--PATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSI 124
E EE ++ N P+ L C AS PA ++ W+ KD + D+ L EV +
Sbjct: 3534 EHEEISVIVNNPLELTCIASGIPAPKM------TWM--KDGRPLPQTDQVQTLGGGEV-L 3584
Query: 125 EISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFE--QEPLGKEVSLEQ 182
IS QVE+ C+A S AG K Y+ ++ EP V +
Sbjct: 3585 RISTAQVEDTGR-----YTCLASSPAGDDD--KEYLVRVHVPPNIAGTDEPRDITVLRNR 3637
Query: 183 EVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAK 242
+V L+C+ + +P + WL+N + + R ++ L I A L DTANYTCVA
Sbjct: 3638 QVTLECKS-DAVPPPVITWLRNGERLQATP-RVRILSGGRYLQINNADLGDTANYTCVAS 3695
Query: 243 NIVAKRKSTTATVIVYVN 260
NI K TT I+ VN
Sbjct: 3696 NIAGK---TTREFILTVN 3710
Score = 49.3 bits (116), Expect = 2e-05
Identities = 27/77 (35%), Positives = 42/77 (54%), Gaps = 6/77 (7%)
Query: 182 QEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITI--DHNLIIKQARLSDTANYTC 239
Q++ L C G P+ E W+KN ++ +N YIT+ D +L I++ +L D YTC
Sbjct: 905 QQLTLPCTLLAGNPIPERRWIKNSAMLL----QNPYITVRSDGSLHIERVQLQDGGEYTC 960
Query: 240 VAKNIVAKRKSTTATVI 256
VA N+ TT+ V+
Sbjct: 961 VASNVAGTNNKTTSVVV 977
Score = 48.9 bits (115), Expect = 2e-05
Identities = 51/193 (26%), Positives = 78/193 (40%), Gaps = 34/193 (17%)
Query: 68 PEEAYIVKNKPVNLYCKA---SPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSI 124
PE+ ++ N P +L C+A PAT +FK D T R + I
Sbjct: 2582 PEDVTVILNSPTSLVCEAYSYPPATITWFK-----------------DGTPLESNRNIRI 2624
Query: 125 EISRQQVEELFGPEDY--WCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQ--------EPL 174
+ ++ L ED CVA + AG + K Y Y+ + P
Sbjct: 2625 LPGGRTLQILNAQEDNAGRYSCVATNEAG--EMIKHYEVKVYIPPIINKGDLWGPGLSPK 2682
Query: 175 GKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDT 234
++ + + L+C IP A + W K+ + + N H L IK+A++SDT
Sbjct: 2683 EVKIKVNNTLTLECE-AYAIPSASLSWYKDGQPLKSDDHVNIAAN-GHTLQIKEAQISDT 2740
Query: 235 ANYTCVAKNIVAK 247
YTCVA NI +
Sbjct: 2741 GRYTCVASNIAGE 2753
Score = 46.2 bits (108), Expect = 1e-04
Identities = 51/206 (24%), Positives = 94/206 (45%), Gaps = 26/206 (12%)
Query: 56 DPPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETS 115
+PP P +P E +++ N P+ L C+A+ + E ++ + V +
Sbjct: 3986 EPPVIQP----QPSELHVILNNPILLPCEATGTPSPFITWQKEGINVNTSGRNHAVLPSG 4041
Query: 116 GLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSR-KAYVRIAYLRKTFEQEPL 174
GL +ISR V E G CVA + AGT + K V++ + +E +
Sbjct: 4042 GL-------QISR-AVREDAGT----YMCVAQNPAGTALGKIKLNVQVPPVISPHLKEYV 4089
Query: 175 GKEVSLEQEVLLQCRPPEGIPVAEVEWLKN-EDIIDPVEDRNFYITIDHNLIIKQARLSD 233
+++++ + L C +G+P ++ W K+ I++ + R + +L I + D
Sbjct: 4090 ---IAVDKPITLSCE-ADGLPPPDITWHKDGRAIVESIRQR---VLSSGSLQIAFVQPGD 4142
Query: 234 TANYTCVAKNIVAKRKSTTATVIVYV 259
+YTC+A N VA ST+ + V+V
Sbjct: 4143 AGHYTCMAAN-VAGSSSTSTKLTVHV 4167
Score = 44.7 bits (104), Expect = 4e-04
Identities = 40/134 (29%), Positives = 57/134 (42%), Gaps = 26/134 (19%)
Query: 120 REVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQE------- 172
R++ I I+ + L+ CVA + AGT K K Y Y+R T
Sbjct: 2252 RQLQISIAEKSDAALYS-------CVASNVAGTAK--KEYNLQVYIRPTITNSGSHPTEI 2302
Query: 173 --PLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQAR 230
GK +SLE EV +GIP V W+K+ + + + H L +K
Sbjct: 2303 IVTRGKSISLECEV-------QGIPPPTVTWMKDGHPLIKAKGVEI-LDEGHILQLKNIH 2354
Query: 231 LSDTANYTCVAKNI 244
+SDT Y CVA N+
Sbjct: 2355 VSDTGRYVCVAVNV 2368
Score = 42.0 bits (97), Expect = 0.003
Identities = 31/107 (28%), Positives = 49/107 (45%), Gaps = 8/107 (7%)
Query: 144 CVAWSSAGTTKSR---KAYVRIAYL---RKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVA 197
C A ++AG K + YVR R + +P+ V +EV L C + +P
Sbjct: 1051 CTATNTAGYAKRKVQLTVYVRPRVFGDQRGLSQDKPVEISVLAGEEVTLPCEV-KSLPPP 1109
Query: 198 EVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNI 244
+ W K +I P R+ ++ ++ I + R SD+ Y CVA NI
Sbjct: 1110 IITWAKETQLISPFSPRHTFLP-SGSMKITETRTSDSGMYLCVATNI 1155
Score = 42.0 bits (97), Expect = 0.003
Identities = 34/117 (29%), Positives = 52/117 (44%), Gaps = 4/117 (3%)
Query: 143 QCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWL 202
+CVA +SAG T+ Y ++ + V + V L+C GIP + WL
Sbjct: 1990 KCVAINSAGATEL--FYSLQVHVAPSISGSNNMVAVVVNNPVRLECEA-RGIPAPSLTWL 2046
Query: 203 KNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYV 259
K+ + + ++ L + A++SDT YTCVA N A K + VYV
Sbjct: 2047 KDGSPVSSFSNGLQVLSGGRILALTSAQISDTGRYTCVAVN-AAGEKQRDIDLRVYV 2102
Score = 42.0 bits (97), Expect = 0.003
Identities = 55/194 (28%), Positives = 89/194 (45%), Gaps = 30/194 (15%)
Query: 61 LPHFLIEPEEAYIVK--NKPVNLYCKAS--PATQIYFKCNSEWVHQKDHIVDERVDETSG 116
+P + PE IV+ + PV L C A+ P I W+ K+H +R++ +
Sbjct: 3149 VPPSIEGPEREVIVETISNPVTLTCDATGIPPPTI------AWL--KNH---KRIENSDS 3197
Query: 117 LIVREVS----IEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQE 172
L VR +S ++I+R Q + +Y C+A + G K++K Y + +
Sbjct: 3198 LEVRILSGGSKLQIARSQHSD---SGNY--TCIASNMEG--KAQKYYFLSIQVPPSVAGA 3250
Query: 173 PLGKEVS--LEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLI-IKQA 229
+ +VS L + V L C GIP ++WLK+ I E ++ + + + I A
Sbjct: 3251 EIPSDVSVLLGENVELVCNA-NGIPTPLIQWLKDGKPIASGETERIRVSANGSTLNIYGA 3309
Query: 230 RLSDTANYTCVAKN 243
SDT YTCVA N
Sbjct: 3310 LTSDTGKYTCVATN 3323
Score = 40.8 bits (94), Expect = 0.006
Identities = 28/109 (25%), Positives = 52/109 (47%), Gaps = 4/109 (3%)
Query: 144 CVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLK 203
C+A ++AGT + R+ +++ ++ + P V + + L C GIP + W K
Sbjct: 3783 CMATNAAGTDR-RRIDLQV-HVPPSIAPGPTNMTVIVNVQTTLACEAT-GIPKPSINWRK 3839
Query: 204 NEDIIDPVEDRNFY-ITIDHNLIIKQARLSDTANYTCVAKNIVAKRKST 251
N +++ +++N Y + +L+I + DTA Y C N K T
Sbjct: 3840 NGHLLNVDQNQNSYRLLSSGSLVIISPSVDDTATYECTVTNGAGDDKRT 3888
Score = 40.0 bits (92), Expect = 0.010
Identities = 43/180 (23%), Positives = 79/180 (43%), Gaps = 22/180 (12%)
Query: 67 EPEEAYIVKNKPVNLYCK--ASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSI 124
EP + +++N+ V L CK A P I + N E + RV SG +++
Sbjct: 3627 EPRDITVLRNRQVTLECKSDAVPPPVITWLRNGERLQ-----ATPRVRILSGGRYLQINN 3681
Query: 125 EISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEV 184
+L +Y CVA + AG K+ + ++ + + P + L +
Sbjct: 3682 A-------DLGDTANY--TCVASNIAG--KTTREFILTVNVPPNIKGGPQSLVILLNKST 3730
Query: 185 LLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLI-IKQARLSDTANYTCVAKN 243
+L+C EG+P + W K+ ++ R Y +++ + I+ A ++DT Y C+A N
Sbjct: 3731 VLECIA-EGVPTPRITWRKDGAVLAGNHAR--YSILENGFLHIQSAHVTDTGRYLCMATN 3787
Score = 39.7 bits (91), Expect = 0.013
Identities = 29/102 (28%), Positives = 49/102 (48%), Gaps = 4/102 (3%)
Query: 143 QCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQE-VLLQCRPPEGIPVAEVEW 201
+C+A ++AG K K + ++ T + L + V ++ + V LQC GIP + W
Sbjct: 1804 RCMAANTAGDHK--KEFEVTVHVPPTIKSSGLSERVVVKYKPVALQCIA-NGIPNPSITW 1860
Query: 202 LKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKN 243
LK++ ++ + + L I + L D YTCVA N
Sbjct: 1861 LKDDQPVNTAQGNLKIQSSGRVLQIAKTLLEDAGRYTCVATN 1902
Score = 38.9 bits (89), Expect = 0.023
Identities = 57/249 (22%), Positives = 101/249 (40%), Gaps = 25/249 (10%)
Query: 68 PEEAYIVKNKPVNLYC--KASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSIE 125
PEE ++ NK + C SPA + ++ + + + + DH ++G I++ ++ +
Sbjct: 2879 PEEVTVLVNKSALIECLSSGSPAPRNSWQKDGQPLLEDDH----HKFLSNGRILQILNTQ 2934
Query: 126 ISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVL 185
I+ + CVA ++AG+ K + + + + V + +
Sbjct: 2935 IT----------DIGRYVCVAENTAGSAK-KYFNLNVHVPPSVIGPKSENLTVVVNNFIS 2983
Query: 186 LQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIV 245
L C G P ++ WLKNE I + + L I +A++SD YTC+A N
Sbjct: 2984 LTCEV-SGFPPPDLSWLKNEQPIK-LNTNTLIVPGGRTLQIIRAKVSDGGEYTCIAINQA 3041
Query: 246 AK-RKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPL-----NGGAFC 299
+ +K + TV V + SV N R G + P P+ NG
Sbjct: 3042 GESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECESNAVPPPVITWYKNGRMIT 3101
Query: 300 EGQSVQKIA 308
E V+ +A
Sbjct: 3102 ESTHVEILA 3110
Score = 38.5 bits (88), Expect = 0.029
Identities = 36/123 (29%), Positives = 60/123 (48%), Gaps = 7/123 (5%)
Query: 144 CVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLK 203
CVA ++AG K R +R+ Y+ E V + Q V L C+ + IP + WLK
Sbjct: 2083 CVAVNAAGE-KQRDIDLRV-YVPPNIMGEEQNVSVLISQAVELLCQS-DAIPPPTLTWLK 2139
Query: 204 NEDIIDPVEDRNFYITIDHNLI-IKQARLSDTANYTCVAKNIVAK-RKSTTATVIVYVNG 261
+ + ++ I+ + +++ I+ A++ DT YTC A N+ K K+ + V N
Sbjct: 2140 DGHPL--LKKPGLSISENRSVLKIEDAQVQDTGRYTCEATNVAGKTEKNYNVNIWVPPNI 2197
Query: 262 GWS 264
G S
Sbjct: 2198 GGS 2200
Score = 37.0 bits (84), Expect = 0.086
Identities = 37/119 (31%), Positives = 54/119 (45%), Gaps = 7/119 (5%)
Query: 144 CVAWSSAGTTKSRKAY-VRIAYLRKTFEQEPLGK-EVSLEQEVLLQCRPPEGIPVAEVEW 201
C+A + AG +K + + V + K + E L V V L+C +P + W
Sbjct: 3035 CIAINQAGESKKKFSLTVYVPPSIKDHDSESLSVVNVREGTSVSLECES-NAVPPPVITW 3093
Query: 202 LKNEDIIDPVEDRNFYITIDHNLI-IKQARLSDTANYTCVAKNIVAKRKSTTATVIVYV 259
KN +I E + I D ++ IK+A +SDT Y C A N VA R + VYV
Sbjct: 3094 YKNGRMI--TESTHVEILADGQMLHIKKAEVSDTGQYVCRAIN-VAGRDDKNFHLNVYV 3149
Score = 37.0 bits (84), Expect = 0.086
Identities = 23/70 (32%), Positives = 35/70 (50%), Gaps = 2/70 (2%)
Query: 179 SLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHN-LIIKQARLSDTANY 237
++ V L C GIP + WLKN I+ + I + L I +++ SD+ NY
Sbjct: 3164 TISNPVTLTC-DATGIPPPTIAWLKNHKRIENSDSLEVRILSGGSKLQIARSQHSDSGNY 3222
Query: 238 TCVAKNIVAK 247
TC+A N+ K
Sbjct: 3223 TCIASNMEGK 3232
Score = 36.2 bits (82), Expect = 0.15
Identities = 31/103 (30%), Positives = 50/103 (48%), Gaps = 10/103 (9%)
Query: 144 CVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLK 203
C+A +SAGT K I + Q L V+L +++C+ GIP +V+W K
Sbjct: 681 CLASNSAGTDKQNSTLRYIEAPKLMVVQSEL--LVALGDITVMECKT-SGIPPPQVKWFK 737
Query: 204 NEDIIDPVEDRNFYITIDHNL---IIKQARLSDTANYTCVAKN 243
+ + P + ++ ID L I++ + D +YTCVA N
Sbjct: 738 GDLELRP----STFLIIDPLLGLLKIQETQDLDAGDYTCVAIN 776
Score = 36.2 bits (82), Expect = 0.15
Identities = 26/102 (25%), Positives = 48/102 (47%), Gaps = 6/102 (5%)
Query: 144 CVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLK 203
CVA ++AG + ++ TF + P ++ +++ L C+ GIP+ ++ W
Sbjct: 4239 CVANNAAGEDTHTVSLT--VHVLPTFTELPGDVSLNKGEQLRLSCKAT-GIPLPKLTWTF 4295
Query: 204 NEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIV 245
N +II D + L+I++ D+ Y C A+N V
Sbjct: 4296 NNNIIPAHFDS---VNGHSELVIERVSKEDSGTYVCTAENSV 4334
Score = 35.8 bits (81), Expect = 0.19
Identities = 21/58 (36%), Positives = 31/58 (53%), Gaps = 3/58 (5%)
Query: 193 GIPVAEVEWLKNEDIIDPVEDRNFYITID-HNLIIKQARLSDTANYTCVAKNIVAKRK 249
G P + WLK+ +ID E F I ++ L+I QA++S+T Y C+A N K
Sbjct: 1760 GSPPPTIMWLKDGQLID--ERDGFKILLNGRKLVIAQAQVSNTGLYRCMAANTAGDHK 1815
Score = 35.4 bits (80), Expect = 0.25
Identities = 45/178 (25%), Positives = 77/178 (43%), Gaps = 21/178 (11%)
Query: 70 EAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSIEISRQ 129
E +VK KPV L C A+ N KD D+ V+ G + + S +
Sbjct: 1835 ERVVVKYKPVALQCIANGIP------NPSITWLKD---DQPVNTAQGNLKIQSSGRVL-- 1883
Query: 130 QVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGK----EVSLEQEVL 185
Q+ + + CVA ++AG T+ ++++ ++ + E GK V + V
Sbjct: 1884 QIAKTLLEDAGRYTCVATNAAGETQQ---HIQL-HVHEPPSLEDAGKMLNETVLVSNPVQ 1939
Query: 186 LQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKN 243
L+C+ G PV + W K+ ++ F + + I+ A++SD Y CVA N
Sbjct: 1940 LECKAA-GNPVPVITWYKDNRLLSGSTSMTF-LNRGQIIDIESAQISDAGIYKCVAIN 1995
Score = 35.4 bits (80), Expect = 0.25
Identities = 20/64 (31%), Positives = 34/64 (53%), Gaps = 2/64 (3%)
Query: 180 LEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTC 239
++ + ++CR G P ++ WLKN + P+ + + I +A++SD A YTC
Sbjct: 3356 VDTSINIECRAT-GTPPPQINWLKN-GLPLPLSSHIRLLAAGQVIRIVRAQVSDVAVYTC 3413
Query: 240 VAKN 243
VA N
Sbjct: 3414 VASN 3417
Score = 35.0 bits (79), Expect = 0.32
Identities = 33/119 (27%), Positives = 54/119 (45%), Gaps = 7/119 (5%)
Query: 143 QCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVS--LEQEVLLQCRPPEGIPVAEVE 200
QC ++AG K K Y+ + + + ++S + + L+C G+P+ +
Sbjct: 1524 QCTVSNAAG--KQAKDIKLTIYIPPSIKGGNVTTDISVLINSLIKLECET-RGLPMPAIT 1580
Query: 201 WLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYV 259
W K+ I + YI L I +A++SD+A YTC N VA + V VYV
Sbjct: 1581 WYKDGQPIMS-SSQALYIDKGQYLHIPRAQVSDSATYTCHVAN-VAGTAEKSFHVDVYV 1637
Score = 33.5 bits (75), Expect = 0.95
Identities = 38/178 (21%), Positives = 69/178 (38%), Gaps = 18/178 (10%)
Query: 68 PEEAYIVKNKPVNLYCKAS--PATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSIE 125
P ++ N L C+A+ P I ++ N H+++ ++ S ++ S+
Sbjct: 3810 PTNMTVIVNVQTTLACEATGIPKPSINWRKNG-------HLLNVDQNQNSYRLLSSGSLV 3862
Query: 126 ISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVL 185
I V++ E C + AG K + + + EP V+ +
Sbjct: 3863 IISPSVDDTATYE-----CTVTNGAGDDK--RTVDLTVQVPPSIADEPTDFLVTKHAPAV 3915
Query: 186 LQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKN 243
+ C G+P + W KN + P D + I + I +L+ YTCVA+N
Sbjct: 3916 ITCTA-SGVPFPSIHWTKNGIRLLPRGD-GYRILSSGAIEILATQLNHAGRYTCVARN 3971
Score = 32.7 bits (73), Expect = 1.6
Identities = 40/184 (21%), Positives = 80/184 (43%), Gaps = 26/184 (14%)
Query: 73 IVKNKPVNLYCK---ASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSIEISRQ 129
++ N P++LYC+ A P T ++K + + D ++ ++ ++I R
Sbjct: 2789 VIINNPISLYCETNAAPPPTLTWYK-DGHPLTSSDKVL---------ILPGGRVLQIPRA 2838
Query: 130 QVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAY---LRKTFEQEPLGKEVSLEQEVLL 186
+VE+ CVA + AG S + VR+ ++ P V + + L+
Sbjct: 2839 KVEDAGR-----YTCVAVNEAGED-SLQYDVRVLVPPIIKGANSDLPEEVTVLVNKSALI 2892
Query: 187 QCRPPEGIPVAEVEWLKN-EDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIV 245
+C G P W K+ + +++ +D + +++ L I +++D Y CVA+N
Sbjct: 2893 ECLS-SGSPAPRNSWQKDGQPLLE--DDHHKFLSNGRILQILNTQITDIGRYVCVAENTA 2949
Query: 246 AKRK 249
K
Sbjct: 2950 GSAK 2953
Score = 32.3 bits (72), Expect = 2.1
Identities = 42/190 (22%), Positives = 72/190 (37%), Gaps = 29/190 (15%)
Query: 68 PEEAYIVKNKPVNLYCKAS---PATQIYFKCNSEWVHQKDHIVDERVDETSGLIVREVSI 124
P E + + K ++L C+ P T + K + K E +DE L ++ + +
Sbjct: 2299 PTEIIVTRGKSISLECEVQGIPPPTVTWMKDGHPLIKAKGV---EILDEGHILQLKNIHV 2355
Query: 125 EISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTF---EQEPLGKEVSLE 181
+ + V CVA + AG T K Y + + + P V +
Sbjct: 2356 SDTGRYV------------CVAVNVAGMTD--KKYDLSVHAPPSIIGNHRSPENISVVEK 2401
Query: 182 QEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIK--QARLSDTANYTC 239
V L C GIP+ + W K+ PV N + +++ Q + D YTC
Sbjct: 2402 NSVSLTCEA-SGIPLPSITWFKDGW---PVSLSNSVRILSGGRMLRLMQTTMEDAGQYTC 2457
Query: 240 VAKNIVAKRK 249
V +N + +
Sbjct: 2458 VVRNAAGEER 2467
Score = 31.2 bits (69), Expect = 4.7
Identities = 27/93 (29%), Positives = 41/93 (44%), Gaps = 9/93 (9%)
Query: 169 FEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNL---- 224
F QEP + + V L C +G P ++W + +++ P+ R F ++ L
Sbjct: 795 FIQEPADVSMEIGSNVTLPCYV-QGYPEPTIKWRRLDNM--PIFSRPFSVSSISQLRTGA 851
Query: 225 -IIKQARLSDTANYTCVAKNIVAKRKS-TTATV 255
I SD Y C A+N K +S TT TV
Sbjct: 852 LFILNLWASDKGTYICEAENQFGKIQSETTVTV 884
>gi|40317628 thrombospondin 2 precursor [Homo sapiens]
Length = 1172
Score = 109 bits (273), Expect = 1e-23
Identities = 54/146 (36%), Positives = 74/146 (50%), Gaps = 5/146 (3%)
Query: 227 KQARLSDTANYTCVAKNIVAKRKSTT-ATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTR 285
++ R D + TC+ +I + S + + +GGWS W+ WS C+ CG G R R
Sbjct: 403 QRGRSCDVTSNTCLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIR 462
Query: 286 TCTNPAPLNGGAFCEGQSVQKIACT-TLCPVDGRWTPWSKWSTCGTECT---HWRRRECT 341
C +P P GG C+G + AC CP+DGRW+PWS WS C C R R C
Sbjct: 463 LCNSPVPQMGGKNCKGSGRETKACQGAPCPIDGRWSPWSPWSACTVTCAGGIRERTRVCN 522
Query: 342 APAPKNGGKDCDGLVLQSKNCTDGLC 367
+P P+ GGK C G V + + C C
Sbjct: 523 SPEPQYGGKACVGDVQERQMCNKRSC 548
Score = 84.7 bits (208), Expect = 4e-16
Identities = 47/138 (34%), Positives = 64/138 (46%), Gaps = 13/138 (9%)
Query: 238 TCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGA 297
TC + + V + V GWS W EW+ C+ CG G Q+R R+C +
Sbjct: 359 TCASPSFVEGECCPSCLHSVDGEEGWSPWAEWTQCSVTCGSGTQQRGRSCDVTSNT---- 414
Query: 298 FCEGQSVQKIACT-----TLCPVDGRWTPWSKWSTCGTEC---THWRRRECTAPAPKNGG 349
C G S+Q AC+ T DG W+ WS WS+C C R R C +P P+ GG
Sbjct: 415 -CLGPSIQTRACSLSKCDTRIRQDGGWSHWSPWSSCSVTCGVGNITRIRLCNSPVPQMGG 473
Query: 350 KDCDGLVLQSKNCTDGLC 367
K+C G ++K C C
Sbjct: 474 KNCKGSGRETKACQGAPC 491
>gi|147904700 semaphorin 5A [Homo sapiens]
Length = 1074
Score = 107 bits (267), Expect = 5e-23
Identities = 51/122 (41%), Positives = 63/122 (51%), Gaps = 4/122 (3%)
Query: 259 VNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTL-CPVDG 317
VNG WS WT WS C+ C RG + R R C NP P GG C G S++ C L CPVDG
Sbjct: 783 VNGAWSAWTSWSQCSRDCSRGIRNRKRVCNNPEPKYGGMPCLGPSLEYQECNILPCPVDG 842
Query: 318 RWTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQTAPDS 374
W+ WS W+ C C + R R C+ PAP GG C GL + C C ++ +
Sbjct: 843 VWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQPCPESWSEW 902
Query: 375 DD 376
D
Sbjct: 903 SD 904
Score = 95.5 bits (236), Expect = 2e-19
Identities = 44/113 (38%), Positives = 59/113 (52%), Gaps = 11/113 (9%)
Query: 260 NGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACT--TLCPVDG 317
NGGW+ WT WS C++ CG G+Q R R+C+NP P +GG C GQ+ ++ C LCP
Sbjct: 595 NGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHLLCPPHM 654
Query: 318 RWTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLC 367
WT W W C +C RRR C G DC G ++ ++C C
Sbjct: 655 FWTGWGPWERCTAQCGGGIQARRRIC------ENGPDCAGCNVEYQSCNTNPC 701
Score = 89.0 bits (219), Expect = 2e-17
Identities = 40/104 (38%), Positives = 54/104 (51%), Gaps = 3/104 (2%)
Query: 259 VNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGR 318
V+G WS W+ W+ C++ CG G+ RTR+C+NPAP GG C G ++ C T P
Sbjct: 840 VDGVWSCWSPWTKCSATCGGGHYMRTRSCSNPAPAYGGDICLGLHTEEALCNTQ-PCPES 898
Query: 319 WTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNC 362
W+ WS WS C R R+C P G C G +S+ C
Sbjct: 899 WSEWSDWSECEASGVQVRARQCILLFPM--GSQCSGNTTESRPC 940
Score = 82.0 bits (201), Expect = 2e-15
Identities = 40/114 (35%), Positives = 59/114 (51%), Gaps = 10/114 (8%)
Query: 259 VNGGWSTWTEWSVCNSRCGRGYQK---RTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPV 315
V+G + W+ W+ C G RTR+C +PAP GG CEG ++ C+
Sbjct: 539 VDGHFGVWSPWTPCTHTDGSAVGSCLCRTRSCDSPAPQCGGWQCEGPGMEIANCSR---- 594
Query: 316 DGRWTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGL 366
+G WTPW+ WS C T C R+R C+ P P++GG+ C G + + C + L
Sbjct: 595 NGGWTPWTSWSPCSTTCGIGFQVRQRSCSNPTPRHGGRVCVGQNREERYCNEHL 648
>gi|27734865 unc-5 homolog C-like [Homo sapiens]
Length = 518
Score = 105 bits (263), Expect = 1e-22
Identities = 117/465 (25%), Positives = 193/465 (41%), Gaps = 52/465 (11%)
Query: 469 PILDPLPNLKIKVYNTSGAVTPQDDLSEFTSKLSPQMTQSLLENEALSLKNQSLARQTDP 528
P+ P P L+ +V T + ++ + +P Q+++ L S AR+ D
Sbjct: 52 PVSQPTPQLENEVSRQHLPATLPEMVAFYQELHTPTQGQTMVRQLMHKLLVFS-AREVDH 110
Query: 529 SCTAFGSFNSLGGHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMDDSQTLL 588
GG L++ ++G+SLLIP GA+ GR + + + + P + +Q L+
Sbjct: 111 R----------GGCLMLQDTGISLLIPPGAVAVGRQERVSLILVWDLSDAPSLSQAQGLV 160
Query: 589 TPVVSCGPPGALLTRPVVLTMHHCADPNTEDWKILLKNQAAQGQ-WEDVVVVGEENFTTP 647
+PVV+CGP GA +P LT HCA+ + + W + G
Sbjct: 161 SPVVACGPHGASFLKPCTLTFKHCAEQPSHARTYSSNTTLLDAKVWRPLGRPGAH----- 215
Query: 648 CYIKLDAEACHILTENLSTYALVGHSTT-KAAAKRLKLAIF-GPLCCSSLEYSIRVYCLD 705
+ C I + S Y V + + A K L+LA+F PL +R+Y L+
Sbjct: 216 ----ASRDECRIHLSHFSLYTCVLEAPVGREARKWLQLAVFCSPLVPGQSHLQLRIYFLN 271
Query: 706 DTQDALKEILHLERQTGGQLLEEPKALHFKGSTHNLRLSIHDIAHSLWKSKLLAKYQEIP 765
+T AL+ L E+ GG+L + F G+ + L + I+ W++ + Q +P
Sbjct: 272 NTPCALQWALTNEQPHGGRLRGPCQLFDFNGARGDQCLKLTYISEG-WENVDDSSCQLVP 330
Query: 766 FYHVWSGSQRNLHCTFTL-----------ERFSLNTVELVCKLCVRQVEGEGQIFQ-LNC 813
H+W G C F E S T E++ + Q E + + L
Sbjct: 331 HLHIWHGK-----CPFRSFCFRRKAADENEDCSALTNEIIVTMHTFQDGLETKYMEILRF 385
Query: 814 TVSEEPT-GIDLPLLDPANTITTVTGPSAFSIPLPIRQKLCSSLDAPQTRGHDWRMLAHK 872
SEE + P+ P P +P + ++L L+ G+DWR LA
Sbjct: 386 QASEEESWAAPPPVSQP---------PPCNRLPPELFEQLRMLLEPNSITGNDWRGLASH 436
Query: 873 LNL-DRYLNYFATKSSPTGVILDLWEAQNFPDGNLSMLAAVLEEM 916
L L + + + + SP IL+L+E QN L L V+E +
Sbjct: 437 LGLCGMKIRFLSCQRSPAAAILELFEEQNGSLQELHYLMTVMERL 481
>gi|4502359 brain-specific angiogenesis inhibitor 3 [Homo sapiens]
Length = 1522
Score = 103 bits (258), Expect = 6e-22
Identities = 51/118 (43%), Positives = 65/118 (55%), Gaps = 8/118 (6%)
Query: 254 TVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACT-TL 312
T + V+G W W+ WS+C+ CGRG + RTR+CT P GG CEG C L
Sbjct: 339 TALCPVHGVWEEWSPWSLCSFTCGRGQRTRTRSCT--PPQYGGRPCEGPETHHKPCNIAL 396
Query: 313 CPVDGRWTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLC 367
CPVDG+W WS WS C C T R R+CTA A +GG +C G +S+ C + C
Sbjct: 397 CPVDGQWQEWSSWSQCSVTCSNGTQQRSRQCTAAA--HGGSECRGPWAESRECYNPEC 452
Score = 88.2 bits (217), Expect = 3e-17
Identities = 45/111 (40%), Positives = 55/111 (49%), Gaps = 11/111 (9%)
Query: 262 GWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIAC--TTLCPVDGRW 319
G W++WS C+ CG+G Q RTRTC +P G C G + C T LCPV G W
Sbjct: 293 GVEEWSQWSTCSVTCGQGSQVRTRTCVSPY----GTHCSGPLRESRVCNNTALCPVHGVW 348
Query: 320 TPWSKWSTCGTECTHWRR---RECTAPAPKNGGKDCDGLVLQSKNCTDGLC 367
WS WS C C +R R CT P+ GG+ C+G K C LC
Sbjct: 349 EEWSPWSLCSFTCGRGQRTRTRSCT--PPQYGGRPCEGPETHHKPCNIALC 397
Score = 79.3 bits (194), Expect = 2e-14
Identities = 37/111 (33%), Positives = 53/111 (47%), Gaps = 4/111 (3%)
Query: 259 VNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIAC-TTLCPVDG 317
V+G W W+ WS C+ C G Q+R+R CT A +GG+ C G + C C +G
Sbjct: 399 VDGQWQEWSSWSQCSVTCSNGTQQRSRQCT--AAAHGGSECRGPWAESRECYNPECTANG 456
Query: 318 RWTPWSKWSTCGTECT-HWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLC 367
+W W WS C C W RR T G+ C+G + + C++ C
Sbjct: 457 QWNQWGHWSGCSKSCDGGWERRIRTCQGAVITGQQCEGTGEEVRRCSEQRC 507
Score = 43.1 bits (100), Expect = 0.001
Identities = 21/65 (32%), Positives = 30/65 (46%), Gaps = 10/65 (15%)
Query: 260 NGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACT--------T 311
NG W+ W WS C+ C G+++R RTC + G CEG + C+
Sbjct: 455 NGQWNQWGHWSGCSKSCDGGWERRIRTC--QGAVITGQQCEGTGEEVRRCSEQRCPAPYE 512
Query: 312 LCPVD 316
+CP D
Sbjct: 513 ICPED 517
>gi|91982767 semaphorin 5B isoform 1 [Homo sapiens]
Length = 1151
Score = 103 bits (256), Expect = 1e-21
Identities = 48/113 (42%), Positives = 61/113 (53%), Gaps = 4/113 (3%)
Query: 259 VNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACT-TLCPVDG 317
V+GGW+ W WS C+ C G++ R RTCTNP P NGG C G + + C CPV G
Sbjct: 852 VSGGWAAWGPWSSCSRDCELGFRVRKRTCTNPEPRNGGLPCVGDAAEYQDCNPQACPVRG 911
Query: 318 RWTPWSKWSTCGTEC--THWRR-RECTAPAPKNGGKDCDGLVLQSKNCTDGLC 367
W+ W+ WS C C H++R R CT+PAP G C GL + C C
Sbjct: 912 AWSCWTSWSPCSASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEALCATQAC 964
Score = 93.6 bits (231), Expect = 8e-19
Identities = 43/113 (38%), Positives = 59/113 (52%), Gaps = 11/113 (9%)
Query: 260 NGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIAC--TTLCPVDG 317
NG W+ W+ W++C++ CG G+Q R R+C+NPAP +GG C G+S ++ C T CPV
Sbjct: 664 NGAWTPWSSWALCSTSCGIGFQVRQRSCSNPAPRHGGRICVGKSREERFCNENTPCPVPI 723
Query: 318 RWTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLC 367
W W WS C + C RRR C G C G ++ K C C
Sbjct: 724 FWASWGSWSKCSSNCGGGMQSRRRAC------ENGNSCLGCGVEFKTCNPEGC 770
Score = 93.6 bits (231), Expect = 8e-19
Identities = 62/188 (32%), Positives = 84/188 (44%), Gaps = 21/188 (11%)
Query: 259 VNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGR 318
V G WS WT WS C++ CG G+ +RTR+CT+PAP G C G ++ C T +G
Sbjct: 909 VRGAWSCWTSWSPCSASCGGGHYQRTRSCTSPAPSPGEDICLGLHTEEALCATQACPEG- 967
Query: 319 WTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNC--------TDGLCMQT 370
W+PWS+WS C + R R C P G C G QS+ C M+
Sbjct: 968 WSPWSEWSKCTDDGAQSRSRHCEELLP--GSSACAGNSSQSRPCPYSEIPVILPASSMEE 1025
Query: 371 APDSDDVALYVGIVIAVIVCLAISVVVALFVYRK----NHRDFESDIIDSSALN-----G 421
A D L + +V I C S ++ L VY + ES ++ + N G
Sbjct: 1026 ATDCAGFNL-IHLVATGISCFLGSGLLTLAVYLSCQHCQRQSQESTLVHPATPNHLHYKG 1084
Query: 422 GFQPVNIK 429
G P N K
Sbjct: 1085 GGTPKNEK 1092
Score = 79.0 bits (193), Expect = 2e-14
Identities = 43/140 (30%), Positives = 65/140 (46%), Gaps = 15/140 (10%)
Query: 231 LSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQK---RTRTC 287
L D++N + +NI A +GG+ W+ W C G R R+C
Sbjct: 585 LEDSSNMSLWTQNITACPVRNVTR-----DGGFGPWSPWQPCEHLDGDNSGSCLCRARSC 639
Query: 288 TNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWSKWSTCGTEC---THWRRRECTAPA 344
+P P GG C G ++ C+ +G WTPWS W+ C T C R+R C+ PA
Sbjct: 640 DSPRPRCGGLDCLGPAIHIANCSR----NGAWTPWSSWALCSTSCGIGFQVRQRSCSNPA 695
Query: 345 PKNGGKDCDGLVLQSKNCTD 364
P++GG+ C G + + C +
Sbjct: 696 PRHGGRICVGKSREERFCNE 715
Score = 53.5 bits (127), Expect = 9e-07
Identities = 38/120 (31%), Positives = 45/120 (37%), Gaps = 32/120 (26%)
Query: 263 WSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTL-CPVDGRWTP 321
W++W WS C+S CG G Q R R C N G C G V+ C CP R TP
Sbjct: 725 WASWGSWSKCSSNCGGGMQSRRRACEN------GNSCLGCGVEFKTCNPEGCPEVRRNTP 778
Query: 322 WSKW-----------------STC--------GTECTHWRRRECTAPAPKNGGKDCDGLV 356
W+ W TC G + R T PA +G D D LV
Sbjct: 779 WTPWLPVNVTQGGARQEQRFRFTCRAPLADPHGLQFGRRRTETRTCPADGSGSCDTDALV 838
>gi|40317626 thrombospondin 1 precursor [Homo sapiens]
Length = 1170
Score = 101 bits (252), Expect = 3e-21
Identities = 46/112 (41%), Positives = 60/112 (53%), Gaps = 4/112 (3%)
Query: 260 NGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIAC-TTLCPVDGR 318
+GGWS W+ WS C+ CG G R R C +P+P G CEG++ + AC CP++G
Sbjct: 435 DGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDACPINGG 494
Query: 319 WTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLC 367
W PWS W C C R R C P P+ GGKDC G V +++ C C
Sbjct: 495 WGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQDC 546
Score = 86.7 bits (213), Expect = 9e-17
Identities = 44/114 (38%), Positives = 59/114 (51%), Gaps = 13/114 (11%)
Query: 262 GWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIA-----CTTLCPVD 316
GWS W+EW+ C++ CG G Q+R R+C + LN CEG SVQ C D
Sbjct: 381 GWSPWSEWTSCSTSCGNGIQQRGRSCDS---LNNR--CEGSSVQTRTCHIQECDKRFKQD 435
Query: 317 GRWTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLC 367
G W+ WS WS+C C R R C +P+P+ GK C+G ++K C C
Sbjct: 436 GGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGKPCEGEARETKACKKDAC 489
Score = 69.3 bits (168), Expect = 2e-11
Identities = 35/96 (36%), Positives = 44/96 (45%), Gaps = 9/96 (9%)
Query: 259 VNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTL-CPVDG 317
+NGGW W+ W +C+ CG G QKR+R C NP P GG C G + C CP+DG
Sbjct: 491 INGGWGPWSPWDICSVTCGGGVQKRSRLCNNPTPQFGGKDCVGDVTENQICNKQDCPIDG 550
Query: 318 RWTPWSKWSTCGTECT-----HWRRRECTAPAPKNG 348
S G +CT W+ C NG
Sbjct: 551 ---CLSNPCFAGVKCTSYPDGSWKCGACPPGYSGNG 583
Score = 39.7 bits (91), Expect = 0.013
Identities = 34/145 (23%), Positives = 57/145 (39%), Gaps = 23/145 (15%)
Query: 299 CEGQSVQKIACTTLC----PVDGRWTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKD 351
C +V C C D W+PWS+W++C T C R R C +
Sbjct: 358 CSNATVPDGECCPRCWPSDSADDGWSPWSEWTSCSTSCGNGIQQRGRSCDSL-----NNR 412
Query: 352 CDGLVLQSKNC----------TDGLCMQTAP-DSDDVALYVGIVIAVIVCLAISVVVALF 400
C+G +Q++ C DG +P S V G++ + +C + S +
Sbjct: 413 CEGSSVQTRTCHIQECDKRFKQDGGWSHWSPWSSCSVTCGDGVITRIRLCNSPSPQMNGK 472
Query: 401 VYRKNHRDFESDIIDSSALNGGFQP 425
R+ ++ D+ +NGG+ P
Sbjct: 473 PCEGEARETKACKKDACPINGGWGP 497
>gi|111118994 brain-specific angiogenesis inhibitor 1 precursor
[Homo sapiens]
Length = 1584
Score = 101 bits (252), Expect = 3e-21
Identities = 50/142 (35%), Positives = 76/142 (53%), Gaps = 11/142 (7%)
Query: 228 QARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTC 287
+ R +++Y+ + +++ + + V+G W W+ WS+C+S CGRG++ RTRTC
Sbjct: 377 RTRFCVSSSYSTQCSGPLREQRLCNNSAVCPVHGAWDEWSPWSLCSSTCGRGFRDRTRTC 436
Query: 288 TNPAPLNGGAFCEGQSVQKIACT-TLCP---VDGRWTPWSKWSTCGTECTHWRR---REC 340
P GG CEG Q C LCP VDG W WS WS C C+ R+ REC
Sbjct: 437 R--PPQFGGNPCEGPEKQTKFCNIALCPGRAVDGNWNEWSSWSACSASCSQGRQQRTREC 494
Query: 341 TAPAPKNGGKDCDGLVLQSKNC 362
P+ GG +C G +++++C
Sbjct: 495 NGPS--YGGAECQGHWVETRDC 514
Score = 90.5 bits (223), Expect = 7e-18
Identities = 42/111 (37%), Positives = 58/111 (52%), Gaps = 4/111 (3%)
Query: 259 VNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIAC-TTLCPVDG 317
V+G W+ W+ WS C++ C +G Q+RTR C P+ GGA C+G V+ C CPVDG
Sbjct: 466 VDGNWNEWSSWSACSASCSQGRQQRTRECNGPS--YGGAECQGHWVETRDCFLQQCPVDG 523
Query: 318 RWTPWSKWSTCGTEC-THWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLC 367
+W W+ W +C C +RRE P GG C G + + C C
Sbjct: 524 KWQAWASWGSCSVTCGAGSQRRERVCSGPFFGGAACQGPQDEYRQCGTQRC 574
Score = 84.7 bits (208), Expect = 4e-16
Identities = 43/113 (38%), Positives = 58/113 (51%), Gaps = 6/113 (5%)
Query: 266 WTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIAC--TTLCPVDGRWTPWS 323
W+ WSVC+S CG G+Q RTR C + + C G ++ C + +CPV G W WS
Sbjct: 360 WSPWSVCSSTCGEGWQTRTRFCVSS---SYSTQCSGPLREQRLCNNSAVCPVHGAWDEWS 416
Query: 324 KWSTCGTECTH-WRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQTAPDSD 375
WS C + C +R R T P+ GG C+G Q+K C LC A D +
Sbjct: 417 PWSLCSSTCGRGFRDRTRTCRPPQFGGNPCEGPEKQTKFCNIALCPGRAVDGN 469
Score = 50.8 bits (120), Expect = 6e-06
Identities = 36/97 (37%), Positives = 41/97 (42%), Gaps = 14/97 (14%)
Query: 261 GGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACT-TLCPVDGRW 319
GGW W+ W C CG G Q RTRTC PAP G CEG + C C GR
Sbjct: 262 GGWKLWSLWGECTRDCGGGLQTRTRTCL-PAPGVEGGGCEGVLEEGRQCNREACGPAGRT 320
Query: 320 TPWSKWSTCGTECTHWRRRECTA--------PAPKNG 348
+ S+ T RRRE PAP+ G
Sbjct: 321 SSRSQ----SLRSTDARRREELGDELQQFGFPAPQTG 353
Score = 50.8 bits (120), Expect = 6e-06
Identities = 23/57 (40%), Positives = 29/57 (50%), Gaps = 3/57 (5%)
Query: 259 VNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIAC-TTLCP 314
V+G W W W C+ CG G Q+R R C+ P GGA C+G + C T CP
Sbjct: 521 VDGKWQAWASWGSCSVTCGAGSQRRERVCS--GPFFGGAACQGPQDEYRQCGTQRCP 575
Score = 37.4 bits (85), Expect = 0.065
Identities = 18/54 (33%), Positives = 24/54 (44%), Gaps = 4/54 (7%)
Query: 317 GRWTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLC 367
G W WS W C +C R R C PAP G C+G++ + + C C
Sbjct: 262 GGWKLWSLWGECTRDCGGGLQTRTRTCL-PAPGVEGGGCEGVLEEGRQCNREAC 314
>gi|4505737 complement factor properdin precursor [Homo sapiens]
Length = 469
Score = 95.1 bits (235), Expect = 3e-19
Identities = 45/114 (39%), Positives = 57/114 (50%), Gaps = 12/114 (10%)
Query: 261 GGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTT--LCPVDGR 318
GGWS W W C+ C +G + R R C +PAP GG C GQ+ + AC T +CP G
Sbjct: 137 GGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGG-HCPGQAQESEACDTQQVCPTHGA 195
Query: 319 WTPWSKWSTCGTEC-------THWRRRECTAPAP--KNGGKDCDGLVLQSKNCT 363
W W W+ C C R R+C+AP P K GK C GL + + CT
Sbjct: 196 WATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCT 249
Score = 78.6 bits (192), Expect = 3e-14
Identities = 38/107 (35%), Positives = 48/107 (44%), Gaps = 5/107 (4%)
Query: 259 VNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTL--CPVD 316
V GGW W S C CG G RTC +P P +GG FC G + + C T CPVD
Sbjct: 256 VAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVD 315
Query: 317 GRWTPWSKWSTCGTECTHWRRREC-TAPAPKNGGKDCDGLVLQSKNC 362
G W W +WS C + + C P ++ G+ C G C
Sbjct: 316 GEWDSWGEWSPCIRR--NMKSISCQEIPGQQSRGRTCRGRKFDGHRC 360
Score = 70.9 bits (172), Expect = 5e-12
Identities = 38/114 (33%), Positives = 54/114 (47%), Gaps = 11/114 (9%)
Query: 260 NGGWSTWTEWSVCNSRCGRG----YQKRTRTCTNPAPLN--GGAFCEGQSVQKIACTTL- 312
+G W+TW W+ C++ C G + R+R C+ P P G C G + ++ CT L
Sbjct: 193 HGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLP 252
Query: 313 -CPVDGRWTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDGLVLQSKNC 362
CPV G W PW S C C +R C P P++GG C G ++ C
Sbjct: 253 PCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHIC 306
Score = 69.3 bits (168), Expect = 2e-11
Identities = 39/112 (34%), Positives = 47/112 (41%), Gaps = 8/112 (7%)
Query: 263 WSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQ---SVQKIACTTLCPVDGRW 319
WS W+ W+ C+ C G Q R R C G G +Q CP G W
Sbjct: 80 WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGW 139
Query: 320 TPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDGLVLQSKNC-TDGLC 367
+ W W C C T RRR C PAPK GG C G +S+ C T +C
Sbjct: 140 SGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGG-HCPGQAQESEACDTQQVC 190
Score = 57.8 bits (138), Expect = 5e-08
Identities = 36/102 (35%), Positives = 44/102 (43%), Gaps = 16/102 (15%)
Query: 259 VNGGWSTWTEWSVCNSRCGR--------GYQKRTRTCTNPAPLNGGAFCEGQSVQKIACT 310
V+G W +W EWS C R + G Q R RTC G C GQ C
Sbjct: 314 VDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRK--FDGHRCAGQQQDIRHCY 371
Query: 311 TL--CPVDGRWTPWSKWSTCGTEC----THWRRRECTAPAPK 346
++ CP+ G W+ WS W C C T R+R CT PK
Sbjct: 372 SIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPK 413
Score = 31.6 bits (70), Expect = 3.6
Identities = 18/54 (33%), Positives = 23/54 (42%), Gaps = 4/54 (7%)
Query: 318 RWTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDG-LVLQSKNCTDGLC 367
RW+ WS W+ C C + R R C + GK G L Q + C D C
Sbjct: 79 RWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQC 132
>gi|223671861 complement factor properdin precursor [Homo sapiens]
Length = 469
Score = 95.1 bits (235), Expect = 3e-19
Identities = 45/114 (39%), Positives = 57/114 (50%), Gaps = 12/114 (10%)
Query: 261 GGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTT--LCPVDGR 318
GGWS W W C+ C +G + R R C +PAP GG C GQ+ + AC T +CP G
Sbjct: 137 GGWSGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGG-HCPGQAQESEACDTQQVCPTHGA 195
Query: 319 WTPWSKWSTCGTEC-------THWRRRECTAPAP--KNGGKDCDGLVLQSKNCT 363
W W W+ C C R R+C+AP P K GK C GL + + CT
Sbjct: 196 WATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCT 249
Score = 78.6 bits (192), Expect = 3e-14
Identities = 38/107 (35%), Positives = 48/107 (44%), Gaps = 5/107 (4%)
Query: 259 VNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTL--CPVD 316
V GGW W S C CG G RTC +P P +GG FC G + + C T CPVD
Sbjct: 256 VAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHICNTAVPCPVD 315
Query: 317 GRWTPWSKWSTCGTECTHWRRREC-TAPAPKNGGKDCDGLVLQSKNC 362
G W W +WS C + + C P ++ G+ C G C
Sbjct: 316 GEWDSWGEWSPCIRR--NMKSISCQEIPGQQSRGRTCRGRKFDGHRC 360
Score = 70.9 bits (172), Expect = 5e-12
Identities = 38/114 (33%), Positives = 54/114 (47%), Gaps = 11/114 (9%)
Query: 260 NGGWSTWTEWSVCNSRCGRG----YQKRTRTCTNPAPLN--GGAFCEGQSVQKIACTTL- 312
+G W+TW W+ C++ C G + R+R C+ P P G C G + ++ CT L
Sbjct: 193 HGAWATWGPWTPCSASCHGGPHEPKETRSRKCSAPEPSQKPPGKPCPGLAYEQRRCTGLP 252
Query: 313 -CPVDGRWTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDGLVLQSKNC 362
CPV G W PW S C C +R C P P++GG C G ++ C
Sbjct: 253 PCPVAGGWGPWGPVSPCPVTCGLGQTMEQRTCNHPVPQHGGPFCAGDATRTHIC 306
Score = 69.3 bits (168), Expect = 2e-11
Identities = 39/112 (34%), Positives = 47/112 (41%), Gaps = 8/112 (7%)
Query: 263 WSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQ---SVQKIACTTLCPVDGRW 319
WS W+ W+ C+ C G Q R R C G G +Q CP G W
Sbjct: 80 WSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQCCPEMGGW 139
Query: 320 TPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDGLVLQSKNC-TDGLC 367
+ W W C C T RRR C PAPK GG C G +S+ C T +C
Sbjct: 140 SGWGPWEPCSVTCSKGTRTRRRACNHPAPKCGG-HCPGQAQESEACDTQQVC 190
Score = 57.8 bits (138), Expect = 5e-08
Identities = 36/102 (35%), Positives = 44/102 (43%), Gaps = 16/102 (15%)
Query: 259 VNGGWSTWTEWSVCNSRCGR--------GYQKRTRTCTNPAPLNGGAFCEGQSVQKIACT 310
V+G W +W EWS C R + G Q R RTC G C GQ C
Sbjct: 314 VDGEWDSWGEWSPCIRRNMKSISCQEIPGQQSRGRTCRGRK--FDGHRCAGQQQDIRHCY 371
Query: 311 TL--CPVDGRWTPWSKWSTCGTEC----THWRRRECTAPAPK 346
++ CP+ G W+ WS W C C T R+R CT PK
Sbjct: 372 SIQHCPLKGSWSEWSTWGLCMPPCGPNPTRARQRLCTPLLPK 413
Score = 31.6 bits (70), Expect = 3.6
Identities = 18/54 (33%), Positives = 23/54 (42%), Gaps = 4/54 (7%)
Query: 318 RWTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDG-LVLQSKNCTDGLC 367
RW+ WS W+ C C + R R C + GK G L Q + C D C
Sbjct: 79 RWSLWSTWAPCSVTCSEGSQLRYRRCVGWNGQCSGKVAPGTLEWQLQACEDQQC 132
>gi|115387099 brain-specific angiogenesis inhibitor 2 [Homo sapiens]
Length = 1585
Score = 92.0 bits (227), Expect = 2e-18
Identities = 43/116 (37%), Positives = 59/116 (50%), Gaps = 8/116 (6%)
Query: 259 VNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQ-KIACTTLCPVDG 317
V+G W W WS+C+ CGRG + R RTC P +GG CEG +Q K+ CPV+G
Sbjct: 363 VHGVWEEWGSWSLCSRSCGRGSRSRMRTCV--PPQHGGKACEGPELQTKLCSMAACPVEG 420
Query: 318 RWTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQT 370
+W W W C T C T R R+C+ P C G + ++ C++ C T
Sbjct: 421 QWLEWGPWGPCSTSCANGTQQRSRKCSVAGP--AWATCTGALTDTRECSNLECPAT 474
Score = 82.8 bits (203), Expect = 1e-15
Identities = 42/105 (40%), Positives = 55/105 (52%), Gaps = 6/105 (5%)
Query: 266 WTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIAC--TTLCPVDGRWTPWS 323
W+ WSVC+ CG+G Q RTR+C + +P G C G + C + CPV G W W
Sbjct: 315 WSPWSVCSLTCGQGLQVRTRSCVS-SPY--GTLCSGPLRETRPCNNSATCPVHGVWEEWG 371
Query: 324 KWSTCGTECTHW-RRRECTAPAPKNGGKDCDGLVLQSKNCTDGLC 367
WS C C R R T P++GGK C+G LQ+K C+ C
Sbjct: 372 SWSLCSRSCGRGSRSRMRTCVPPQHGGKACEGPELQTKLCSMAAC 416
Score = 76.3 bits (186), Expect = 1e-13
Identities = 39/112 (34%), Positives = 52/112 (46%), Gaps = 5/112 (4%)
Query: 259 VNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTL-CPV-D 316
V G W W W C++ C G Q+R+R C+ P A C G C+ L CP D
Sbjct: 418 VEGQWLEWGPWGPCSTSCANGTQQRSRKCSVAGP--AWATCTGALTDTRECSNLECPATD 475
Query: 317 GRWTPWSKWSTCGTEC-THWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLC 367
+W PW+ WS C C T W+RR A G C+G + K C++ C
Sbjct: 476 SKWGPWNAWSLCSKTCDTGWQRRFRMCQATGTQGYPCEGTGEEVKPCSEKRC 527
Score = 39.3 bits (90), Expect = 0.017
Identities = 19/53 (35%), Positives = 25/53 (47%), Gaps = 3/53 (5%)
Query: 263 WSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACT-TLCP 314
W W WS+C+ C G+Q+R R C A G CEG + C+ CP
Sbjct: 478 WGPWNAWSLCSKTCDTGWQRRFRMC--QATGTQGYPCEGTGEEVKPCSEKRCP 528
>gi|134031945 SCO-spondin [Homo sapiens]
Length = 5147
Score = 90.5 bits (223), Expect = 7e-18
Identities = 45/116 (38%), Positives = 60/116 (51%), Gaps = 11/116 (9%)
Query: 259 VNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQS------VQKIACTT- 311
V GGW W+EW++C+ C + R+R C P P +GGA C G++ Q+ AC +
Sbjct: 3407 VPGGWCPWSEWTMCSQPCRGQTRSRSRACACPTPQHGGAPCTGEAGEAGAQHQREACPSY 3466
Query: 312 -LCPVDGRWTPWSKWSTCGTEC--THWRRRECTAPAPKNGGKDCDGLVLQSKNCTD 364
CPVDG W PW WS C C R R C+ P GG+ C G QS+ C +
Sbjct: 3467 ATCPVDGAWGPWGPWSPCDM-CLGQSHRSRACSRPPTPEGGRPCPGNHTQSRPCQE 3521
Score = 87.4 bits (215), Expect = 6e-17
Identities = 41/113 (36%), Positives = 56/113 (49%), Gaps = 9/113 (7%)
Query: 262 GWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVD-GRWT 320
GWS W+ W+ C+ CG G + R R+ +NP GGA CEG + C T+C + WT
Sbjct: 2717 GWSAWSSWAPCDRSCGSGVRARFRSPSNPPAAWGGAPCEGDRQELQGCHTVCGTEVFGWT 2776
Query: 321 PWSKWSTCGTEC------THWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLC 367
PW+ WS+C C WR R P+P G C G Q + C+ +C
Sbjct: 2777 PWTSWSSCSQSCLAPGGGPGWRSRSRLCPSP--GDSSCPGDATQEEPCSPPVC 2827
Score = 80.9 bits (198), Expect = 5e-15
Identities = 45/116 (38%), Positives = 56/116 (48%), Gaps = 12/116 (10%)
Query: 261 GGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIAC-TTLCPVDGRW 319
G W W+ W C+ CG Q R+R C+ P L C G Q AC T CPVDG W
Sbjct: 1695 GAWGPWSPWGPCSRTCGPWGQGRSRRCS-PLGLLVLQNCPGPEHQSQACFTAACPVDGEW 1753
Query: 320 TPWSKWSTCGTEC--THWRRRECTAPAPKNGGKDCDGL------VLQSKNCTDGLC 367
+ WS WS C C T R+R+C +P+NGG+ C L Q+K C C
Sbjct: 1754 STWSPWSVCSEPCRGTMTRQRQC--HSPQNGGRTCAALPGGLHSTRQTKPCPQDGC 1807
Score = 80.5 bits (197), Expect = 7e-15
Identities = 42/125 (33%), Positives = 55/125 (44%), Gaps = 9/125 (7%)
Query: 260 NGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFC----EGQSVQKIACTTLCPV 315
N W++W W C+ CG G Q+R R P P GG +C ++ CPV
Sbjct: 3946 NCSWTSWAPWEPCSRSCGVGQQRRLRAYRPPGP--GGHWCPNILTAYQERRFCNLRACPV 4003
Query: 316 DGRWTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQTAP 372
G W+ WS WS C C R R C++P KNGG C G Q++ C C P
Sbjct: 4004 PGGWSRWSPWSWCDRSCGGGQSLRSRSCSSPPSKNGGAPCAGERHQARLCNPMPCEAGCP 4063
Query: 373 DSDDV 377
+V
Sbjct: 4064 AGMEV 4068
Score = 79.7 bits (195), Expect = 1e-14
Identities = 41/122 (33%), Positives = 60/122 (49%), Gaps = 15/122 (12%)
Query: 262 GWSTWTEWSVCNSRC-----GRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTT-LCPV 315
GW+ WT WS C+ C G G++ R+R C +P G + C G + Q+ C+ +CPV
Sbjct: 2774 GWTPWTSWSSCSQSCLAPGGGPGWRSRSRLCPSP----GDSSCPGDATQEEPCSPPVCPV 2829
Query: 316 DGRWTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQTAP 372
W W+ WSTC C R R C++ AP G C G Q+++C C P
Sbjct: 2830 PSIWGLWAPWSTCSAPCDGGIQTRGRSCSSLAP--GDTTCPGPHSQTRDCNTQPCTAQCP 2887
Query: 373 DS 374
++
Sbjct: 2888 EN 2889
Score = 68.2 bits (165), Expect = 3e-11
Identities = 35/101 (34%), Positives = 44/101 (43%), Gaps = 6/101 (5%)
Query: 266 WTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIAC-TTLCPVDGRWTPWSK 324
W+ WS C+ CG G + + P PL GG+ C + +C CPV G W W
Sbjct: 2506 WSVWSSCSRSCGLGLTFQRQELLRP-PLPGGS-CPRDRFRSQSCFVQACPVAGAWAMWEA 2563
Query: 325 WSTCGTEC---THWRRRECTAPAPKNGGKDCDGLVLQSKNC 362
W C C R+R C P PKNGG C G + C
Sbjct: 2564 WGPCSVSCGGGHQSRQRSCVDPPPKNGGAPCPGASQERAPC 2604
Score = 66.6 bits (161), Expect = 1e-10
Identities = 35/104 (33%), Positives = 47/104 (45%), Gaps = 7/104 (6%)
Query: 229 ARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCT 288
ARL N TCV+ + + GWS WT WS+C+ C G ++R R T
Sbjct: 2960 ARLDSCNNCTCVSGKMACTSERCPVAC------GWSPWTLWSLCSCSCNVGIRRRFRAGT 3013
Query: 289 NPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWSKWSTCGTEC 332
P GGA C+G +++ C +L P G W WS C C
Sbjct: 3014 APPAAFGGAECQGPTMEAEFC-SLRPCPGPGGEWGPWSPCSVPC 3056
Score = 65.5 bits (158), Expect = 2e-10
Identities = 36/116 (31%), Positives = 43/116 (37%), Gaps = 16/116 (13%)
Query: 263 WSTWTEWSVCNSRCGRGYQKRTRTCTN------------PAPLNGGAFCEGQSVQKIACT 310
WS WT WS C++ CG R R C P P C G ++ C
Sbjct: 3186 WSPWTPWSQCSASCGPARCHRHRFCARSPSAVPSTVAPLPLPATPTPLCSGPEAEEEPCL 3245
Query: 311 TL-CPVDGRWTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDGLVLQSKNC 362
C G W PW WS C C R R C P P+ G C+G Q + C
Sbjct: 3246 LQGCDRAGGWGPWGPWSHCSRSCGGGLRSRTRACDQPPPQGLGDYCEGPRAQGEVC 3301
Score = 63.5 bits (153), Expect = 9e-10
Identities = 39/109 (35%), Positives = 44/109 (40%), Gaps = 22/109 (20%)
Query: 261 GGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTL-CPVDGRW 319
GGW W WS C+ CG G + RTR C P P G +CEG Q C L CPV
Sbjct: 3253 GGWGPWGPWSHCSRSCGGGLRSRTRACDQPPPQGLGDYCEGPRAQGEVCQALPCPV---- 3308
Query: 320 TPWSKWSTCGTECTHWRRRE---CTAPAPKNGGKDCDGLVLQSKNCTDG 365
T CT E C P P++ CD LV C G
Sbjct: 3309 ----------TNCTAIEGAEYSPCGPPCPRS----CDDLVHCVWRCQPG 3343
Score = 63.2 bits (152), Expect = 1e-09
Identities = 37/123 (30%), Positives = 52/123 (42%), Gaps = 25/123 (20%)
Query: 259 VNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGR 318
V G W+ W W C+ CG G+Q R R+C +P P NGGA C G S ++ C L P G
Sbjct: 2554 VAGAWAMWEAWGPCSVSCGGGHQSRQRSCVDPPPKNGGAPCPGASQERAPC-GLQPCSG- 2611
Query: 319 WTPWSKWSTCGTECTHWR--------RRECTAPAPKN-----GGKDCDGLVLQSKNCTDG 365
GT+C R ++ P P + + C G ++ C G
Sbjct: 2612 ----------GTDCELGRVYVSADLCQKGLVPPCPPSCLDPKANRSCSGHCVEGCRCPPG 2661
Query: 366 LCM 368
L +
Sbjct: 2662 LLL 2664
Score = 61.2 bits (147), Expect = 4e-09
Identities = 28/74 (37%), Positives = 38/74 (51%), Gaps = 1/74 (1%)
Query: 259 VNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGR 318
V GGWS W+ WS C+ CG G R+R+C++P NGGA C G+ Q C + P +
Sbjct: 4003 VPGGWSRWSPWSWCDRSCGGGQSLRSRSCSSPPSKNGGAPCAGERHQARLCNPM-PCEAG 4061
Query: 319 WTPWSKWSTCGTEC 332
+ TC C
Sbjct: 4062 CPAGMEVVTCANRC 4075
Score = 56.6 bits (135), Expect = 1e-07
Identities = 24/53 (45%), Positives = 30/53 (56%), Gaps = 4/53 (7%)
Query: 306 KIACTTL-CPVDGRWTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDG 354
++ CT L CPV G W PWS+W+ C C T R R C P P++GG C G
Sbjct: 3397 RLNCTDLPCPVPGGWCPWSEWTMCSQPCRGQTRSRSRACACPTPQHGGAPCTG 3449
Score = 55.8 bits (133), Expect = 2e-07
Identities = 39/127 (30%), Positives = 52/127 (40%), Gaps = 26/127 (20%)
Query: 260 NGGWSTWTEWSVCNSRCGR-GYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTL-CP--- 314
+GG+ W+ W C+ CG G + R+R C P G C G Q + C + CP
Sbjct: 3811 DGGFGPWSPWGPCSRSCGGLGTRTRSRQCVLTMPTLSGQGCRGPR-QDLECPSPDCPGAE 3869
Query: 315 ---------VDGRWTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDG 365
+ G W PWS WS C CT R PA ++ + C NCT G
Sbjct: 3870 GSTVEPVTGLPGGWGPWSSWSPCSRSCTDPAR-----PAWRSRTRLC------LANCTMG 3918
Query: 366 LCMQTAP 372
+Q P
Sbjct: 3919 DPLQERP 3925
Score = 54.3 bits (129), Expect = 5e-07
Identities = 41/140 (29%), Positives = 54/140 (38%), Gaps = 43/140 (30%)
Query: 263 WSTWTEWSVCNSRCG-RGYQKRTRTCTN---------------PAPLN------------ 294
WS W+ WS C+ CG RG Q R R+ T+ P P
Sbjct: 4162 WSHWSAWSPCSHSCGPRGQQSRFRSSTSGSWAPECREEQSQSQPCPQPSCPPLCLQGTRS 4221
Query: 295 ---GGAFCEGQSVQKIACT--------TLCPVDGRWTPWSKWSTCGTEC---THWRRREC 340
G ++ +G+ Q+ +CT T C V WT WS WS C C R R C
Sbjct: 4222 RTLGDSWLQGEC-QRCSCTPEGVICEDTECAVPEAWTLWSSWSDCPVSCGGGNQVRTRAC 4280
Query: 341 TAPAPKNGGKDCDGLVLQSK 360
A AP + C G Q++
Sbjct: 4281 RAAAPHHRSPPCLGPDTQTR 4300
Score = 50.8 bits (120), Expect = 6e-06
Identities = 29/89 (32%), Positives = 42/89 (47%), Gaps = 14/89 (15%)
Query: 279 GYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTT-LCPVDGRWTPWSKWSTCGTECT---H 334
G R +C N ++G K+ACT+ CPV W+PW+ WS C C
Sbjct: 2957 GAMARLDSCNNCTCVSG----------KMACTSERCPVACGWSPWTLWSLCSCSCNVGIR 3006
Query: 335 WRRRECTAPAPKNGGKDCDGLVLQSKNCT 363
R R TAP GG +C G ++++ C+
Sbjct: 3007 RRFRAGTAPPAAFGGAECQGPTMEAEFCS 3035
Score = 50.4 bits (119), Expect = 7e-06
Identities = 33/121 (27%), Positives = 49/121 (40%), Gaps = 15/121 (12%)
Query: 249 KSTTATVIVYVNGGWSTWTEWSVCNSRC----GRGYQKRTRTCTNPAPLNGGAFCEGQSV 304
+ +T + + GGW W+ WS C+ C ++ RTR C A G + +
Sbjct: 3869 EGSTVEPVTGLPGGWGPWSSWSPCSRSCTDPARPAWRSRTRLCL--ANCTMGDPLQERPC 3926
Query: 305 QKIACTTL--CPVDG------RWTPWSKWSTCGTECTHWRRRECTAPAPKN-GGKDCDGL 355
+CT L CP G WT W+ W C C ++R A P GG C +
Sbjct: 3927 NLPSCTELPVCPGPGCGAGNCSWTSWAPWEPCSRSCGVGQQRRLRAYRPPGPGGHWCPNI 3986
Query: 356 V 356
+
Sbjct: 3987 L 3987
Score = 48.5 bits (114), Expect = 3e-05
Identities = 33/114 (28%), Positives = 43/114 (37%), Gaps = 14/114 (12%)
Query: 263 WSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQ-----KIACTTLCPVDG 317
W W WS C++ C G Q R R+C++ AP G C G Q CT CP +
Sbjct: 2833 WGLWAPWSTCSAPCDGGIQTRGRSCSSLAP--GDTTCPGPHSQTRDCNTQPCTAQCPENM 2890
Query: 318 RWTPWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQTA 371
+ + G C R C P G +C G C GL + A
Sbjct: 2891 LFRSAEQCHQEGGPCP----RLCLTQGP---GIECTGFCAPGCTCPPGLFLHNA 2937
Score = 48.1 bits (113), Expect = 4e-05
Identities = 24/70 (34%), Positives = 27/70 (38%), Gaps = 2/70 (2%)
Query: 263 WSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPW 322
W+ W+ WS C CG G Q RTR C AP + C G Q CP W
Sbjct: 4256 WTLWSSWSDCPVSCGGGNQVRTRACRAAAPHHRSPPCLGPDTQ--TRQQPCPGLLEACSW 4313
Query: 323 SKWSTCGTEC 332
W C C
Sbjct: 4314 GPWGPCSRSC 4323
Score = 47.8 bits (112), Expect = 5e-05
Identities = 26/61 (42%), Positives = 31/61 (50%), Gaps = 5/61 (8%)
Query: 259 VNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEG--QSVQKIACTTLCPVD 316
V+G WSTW+ WSVC+ C RG R R C +P NGG C + T CP D
Sbjct: 1749 VDGEWSTWSPWSVCSEPC-RGTMTRQRQCHSPQ--NGGRTCAALPGGLHSTRQTKPCPQD 1805
Query: 317 G 317
G
Sbjct: 1806 G 1806
Score = 44.7 bits (104), Expect = 4e-04
Identities = 24/80 (30%), Positives = 30/80 (37%), Gaps = 13/80 (16%)
Query: 261 GGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTL------CP 314
G WS+W W C+ CG G Q R+R C P C G + Q C+T CP
Sbjct: 3646 GVWSSWGPWEDCSVSCGGGEQLRSRRCARPP-------CPGPARQSRTCSTQVCREAGCP 3698
Query: 315 VDGRWTPWSKWSTCGTECTH 334
+ C C H
Sbjct: 3699 AGRLYRECQPGEGCPFSCAH 3718
Score = 44.3 bits (103), Expect = 5e-04
Identities = 18/59 (30%), Positives = 27/59 (45%), Gaps = 4/59 (6%)
Query: 313 CPVDGRWTPWSKWSTC----GTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLC 367
C VD W+ WS W+ C G++ W R P P G+ C G+ +++ C C
Sbjct: 1906 CAVDCGWSSWSPWAKCLGPCGSQSIQWSFRSSNNPRPSGRGRQCRGIHRKARRCQTEPC 1964
Score = 42.0 bits (97), Expect = 0.003
Identities = 30/105 (28%), Positives = 41/105 (39%), Gaps = 13/105 (12%)
Query: 228 QARLSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTC 287
QA D N TCV +++V + W+ WS C++ CG G +R RTC
Sbjct: 4740 QAVQLDCQNCTCVNESLVCPHQECPVL---------GPWSAWSSCSAPCGGGTMERHRTC 4790
Query: 288 TNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTPWSKWSTCGTEC 332
G A C+ Q ++ L P P S C T C
Sbjct: 4791 EGGP---GVAPCQAQDTEQRQECNLQPCP-ECPPGQVLSACATSC 4831
Score = 39.3 bits (90), Expect = 0.017
Identities = 19/54 (35%), Positives = 26/54 (48%), Gaps = 1/54 (1%)
Query: 259 VNGGWSTWTEWSVCNSRCG-RGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTT 311
V+ GWS+W+ W+ C CG + Q R+ NP P G C G + C T
Sbjct: 1908 VDCGWSSWSPWAKCLGPCGSQSIQWSFRSSNNPRPSGRGRQCRGIHRKARRCQT 1961
Score = 39.3 bits (90), Expect = 0.017
Identities = 18/60 (30%), Positives = 23/60 (38%), Gaps = 10/60 (16%)
Query: 313 CPVDGRWTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQ 369
CP G W+ W W C C R R C P C G QS+ C+ +C +
Sbjct: 3642 CPDPGVWSSWGPWEDCSVSCGGGEQLRSRRCARP-------PCPGPARQSRTCSTQVCRE 3694
Score = 38.1 bits (87), Expect = 0.038
Identities = 26/112 (23%), Positives = 39/112 (34%), Gaps = 10/112 (8%)
Query: 265 TWTEWSVCNSRCGRGYQKRTRTC----TNPAPLNGGAFCEGQSVQKIACTT-LCPVDGRW 319
+W W C+ CG G R+ +C P F + C + CP + W
Sbjct: 4312 SWGPWGPCSRSCGPGLASRSGSCPCLMAKADPTCNSTFLH---LDTQGCYSGPCPEECVW 4368
Query: 320 TPWSKWSTCGTECTHWRRRECTAPAPK--NGGKDCDGLVLQSKNCTDGLCMQ 369
+ WS W+ C +R PA + G C L + C C +
Sbjct: 4369 SSWSSWTRCSCRVLVQQRYRHQGPASRGARAGAPCTRLDGHFRPCLISNCSE 4420
Score = 34.7 bits (78), Expect = 0.42
Identities = 16/53 (30%), Positives = 23/53 (43%), Gaps = 3/53 (5%)
Query: 313 CPVDGRWTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDGLVLQSKNC 362
CP+ W+ WS W+ C C R R + P GG C+G + + C
Sbjct: 2712 CPLPCGWSAWSSWAPCDRSCGSGVRARFRSPSNPPAAWGGAPCEGDRQELQGC 2764
Score = 34.3 bits (77), Expect = 0.55
Identities = 22/70 (31%), Positives = 27/70 (38%), Gaps = 11/70 (15%)
Query: 281 QKRTRTCTNPA---PLNGGA-FCEGQSVQKIACTT--LCPVDGRWTPWSKWSTCGTECT- 333
Q R R C +PA P G C Q+ C CP +W+ W WS C C+
Sbjct: 4574 QHRHRLCLDPATGRPWTGAPHLCTAPLSQQRLCPDPGACPDSCQWSLWGPWSPCQVPCSG 4633
Query: 334 ----HWRRRE 339
WR E
Sbjct: 4634 GFRLRWREAE 4643
Score = 33.9 bits (76), Expect = 0.72
Identities = 28/106 (26%), Positives = 41/106 (38%), Gaps = 12/106 (11%)
Query: 263 WSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCP-VDGRWTP 321
WS W WS C C G++ R R A GG C Q+ CP + + T
Sbjct: 4618 WSLWGPWSPCQVPCSGGFRLRWREA--EALCGGG--CREPWAQESCNGGPCPECEAQDTV 4673
Query: 322 WSKWSTCGTECTH-----WRRRECTAPAPKNGGKDCDGLVLQSKNC 362
++ C +C H W R +C + G + G ++Q C
Sbjct: 4674 FT--LDCANQCPHSCADLWDRVQCLQGPCRPGCRCPPGQLVQDGRC 4717
Score = 31.6 bits (70), Expect = 3.6
Identities = 12/25 (48%), Positives = 14/25 (56%)
Query: 261 GGWSTWTEWSVCNSRCGRGYQKRTR 285
G W WS C+ CG GY+ RTR
Sbjct: 3041 GPGGEWGPWSPCSVPCGGGYRNRTR 3065
Score = 30.4 bits (67), Expect = 8.0
Identities = 30/108 (27%), Positives = 42/108 (38%), Gaps = 11/108 (10%)
Query: 263 WSTWTEWSVCNSRCGRGYQKRTRTCTNPAP--LNGGAFCEGQSVQKIACTTLCPVDGRWT 320
WS+W+ W+ C+ C Q+R R PA GA C C + T
Sbjct: 4368 WSSWSSWTRCS--CRVLVQQRYRH-QGPASRGARAGAPCTRLDGHFRPCLISNCSEDSCT 4424
Query: 321 PWSKWSTCGTEC-----THWRRRECTAPAPKNGGKDC-DGLVLQSKNC 362
P ++ CG+ C TH + C P G C GL+ Q+ C
Sbjct: 4425 PPFEFHACGSPCAGLCATHLSHQLCQDLPPCQPGCYCPKGLLEQAGGC 4472
>gi|193083163 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2a [Homo sapiens]
Length = 1394
Score = 84.3 bits (207), Expect = 5e-16
Identities = 67/231 (29%), Positives = 102/231 (44%), Gaps = 28/231 (12%)
Query: 32 SASGTGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKAS--PAT 89
+ G GS + +DF PP + H P + + K +P L CKA P
Sbjct: 32 NGQGQGSRLRQEDF-----------PPRIVEH----PSDVIVSKGEPTTLNCKAEGRPTP 76
Query: 90 QIYFKCNSEWVHQKDHIVDERVDETSG-LIVREVSIEISRQQVEELFGPEDYWCQCVAWS 148
I EW + + ++ D S +++ S+ R P++ CVA +
Sbjct: 77 TI------EWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRSKPDEGSYVCVARN 130
Query: 149 SAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDII 208
G SR A + +A LR F Q P V+ + +L+C+PP G P + W K++ I
Sbjct: 131 YLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRI 190
Query: 209 DPVEDRNFYITI-DHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVY 258
D E+R I+I L+I R SD YTCV N+V +R S A + V+
Sbjct: 191 DDKEER---ISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAELTVF 238
Score = 47.8 bits (112), Expect = 5e-05
Identities = 49/196 (25%), Positives = 85/196 (43%), Gaps = 24/196 (12%)
Query: 64 FLIEPEEAYIVKNKPVNLYC---KASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVR 120
F P + + +P L C + P IY+K + + K+ ER+ G ++
Sbjct: 151 FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKE----ERISIRGGKLM- 205
Query: 121 EVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSL 180
I +R+ ++ CV + G S A + + + R TF + P+ + V
Sbjct: 206 ---ISNTRKSDAGMY-------TCVGTNMVGERDSDPAELTV-FERPTFLRRPINQVVLE 254
Query: 181 EQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCV 240
E+ V +C+ +G P V W K++ + + I D+ L IK+ +D Y C+
Sbjct: 255 EEAVEFRCQV-QGDPQPTVRWKKDDA---DLPRGRYDIKDDYTLRIKKTMSTDEGTYMCI 310
Query: 241 AKNIVAKRK-STTATV 255
A+N V K + S T TV
Sbjct: 311 AENRVGKMEASATLTV 326
Score = 42.4 bits (98), Expect = 0.002
Identities = 26/71 (36%), Positives = 36/71 (50%), Gaps = 2/71 (2%)
Query: 171 QEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQAR 230
Q P + ++++ LL+C+ G P+ + WLK E P D I L IK R
Sbjct: 438 QGPANQTLAVDGTALLKCKAT-GDPLPVISWLK-EGFTFPGRDPRATIQEQGTLQIKNLR 495
Query: 231 LSDTANYTCVA 241
+SDT YTCVA
Sbjct: 496 ISDTGTYTCVA 506
>gi|61888896 roundabout, axon guidance receptor, homolog 2 isoform
ROBO2b [Homo sapiens]
Length = 1378
Score = 82.4 bits (202), Expect = 2e-15
Identities = 70/244 (28%), Positives = 104/244 (42%), Gaps = 28/244 (11%)
Query: 19 LLQMLVLPALALLSASGTGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKP 78
LL L L GS + +DF PP + H P + + K +P
Sbjct: 3 LLMFTQLLLCGFLYVRVDGSRLRQEDF-----------PPRIVEH----PSDVIVSKGEP 47
Query: 79 VNLYCKAS--PATQIYFKCNSEWVHQKDHIVDERVDETSG-LIVREVSIEISRQQVEELF 135
L CKA P I EW + + ++ D S +++ S+ R
Sbjct: 48 TTLNCKAEGRPTPTI------EWYKDGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRRS 101
Query: 136 GPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIP 195
P++ CVA + G SR A + +A LR F Q P V+ + +L+C+PP G P
Sbjct: 102 KPDEGSYVCVARNYLGEAVSRNASLEVALLRDDFRQNPTDVVVAAGEPAILECQPPRGHP 161
Query: 196 VAEVEWLKNEDIIDPVEDRNFYITI-DHNLIIKQARLSDTANYTCVAKNIVAKRKSTTAT 254
+ W K++ ID E+R I+I L+I R SD YTCV N+V +R S A
Sbjct: 162 EPTIYWKKDKVRIDDKEER---ISIRGGKLMISNTRKSDAGMYTCVGTNMVGERDSDPAE 218
Query: 255 VIVY 258
+ V+
Sbjct: 219 LTVF 222
Score = 47.8 bits (112), Expect = 5e-05
Identities = 49/196 (25%), Positives = 85/196 (43%), Gaps = 24/196 (12%)
Query: 64 FLIEPEEAYIVKNKPVNLYC---KASPATQIYFKCNSEWVHQKDHIVDERVDETSGLIVR 120
F P + + +P L C + P IY+K + + K+ ER+ G ++
Sbjct: 135 FRQNPTDVVVAAGEPAILECQPPRGHPEPTIYWKKDKVRIDDKE----ERISIRGGKLM- 189
Query: 121 EVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSL 180
I +R+ ++ CV + G S A + + + R TF + P+ + V
Sbjct: 190 ---ISNTRKSDAGMY-------TCVGTNMVGERDSDPAELTV-FERPTFLRRPINQVVLE 238
Query: 181 EQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCV 240
E+ V +C+ +G P V W K++ + + I D+ L IK+ +D Y C+
Sbjct: 239 EEAVEFRCQV-QGDPQPTVRWKKDDA---DLPRGRYDIKDDYTLRIKKTMSTDEGTYMCI 294
Query: 241 AKNIVAKRK-STTATV 255
A+N V K + S T TV
Sbjct: 295 AENRVGKMEASATLTV 310
Score = 42.4 bits (98), Expect = 0.002
Identities = 26/71 (36%), Positives = 36/71 (50%), Gaps = 2/71 (2%)
Query: 171 QEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQAR 230
Q P + ++++ LL+C+ G P+ + WLK E P D I L IK R
Sbjct: 422 QGPANQTLAVDGTALLKCKAT-GDPLPVISWLK-EGFTFPGRDPRATIQEQGTLQIKNLR 479
Query: 231 LSDTANYTCVA 241
+SDT YTCVA
Sbjct: 480 ISDTGTYTCVA 490
>gi|4506569 roundabout 1 isoform a [Homo sapiens]
Length = 1651
Score = 79.7 bits (195), Expect = 1e-14
Identities = 63/226 (27%), Positives = 100/226 (44%), Gaps = 28/226 (12%)
Query: 36 TGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKAS--PATQIYF 93
TGS + +DF PP + H P + + K +P L CKA P I
Sbjct: 57 TGSRLRQEDF-----------PPRIVEH----PSDLIVSKGEPATLNCKAEGRPTPTI-- 99
Query: 94 KCNSEWVHQKDHIVDERVDETSG-LIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGT 152
EW + + ++ D S +++ S+ R P++ CVA + G
Sbjct: 100 ----EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGE 155
Query: 153 TKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVE 212
S A + +A LR F Q P V++ + +++C+PP G P + W K+ P++
Sbjct: 156 AVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDG---SPLD 212
Query: 213 DRNFYITI-DHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIV 257
D++ ITI L+I R SD Y CV N+V +R+S A + V
Sbjct: 213 DKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTV 258
Score = 48.9 bits (115), Expect = 2e-05
Identities = 34/113 (30%), Positives = 54/113 (47%), Gaps = 6/113 (5%)
Query: 144 CVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLK 203
CV + G +S A + + R +F + P V+++ +C G PV V W K
Sbjct: 240 CVGTNMVGERESEVAELTVLE-RPSFVKRPSNLAVTVDDSAEFKCEA-RGDPVPTVRWRK 297
Query: 204 NEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRK-STTATV 255
++ + + I DH L I++ D +YTCVA+N+V K + S T TV
Sbjct: 298 DDG---ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 347
Score = 41.2 bits (95), Expect = 0.005
Identities = 44/189 (23%), Positives = 79/189 (41%), Gaps = 21/189 (11%)
Query: 62 PHFLIEPEEAYIVKNKPVNLYCKAS--PATQIYFKC----NSEWVHQKDHIVDE-RVDET 114
PHF+++P + + + V C+A+ P I+++ N + +Q V +T
Sbjct: 351 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 410
Query: 115 SGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRK--TFEQE 172
L + V R V Y CQ + + + TK+ + R Q
Sbjct: 411 GDLTITNVQ----RSDVGY------YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG 460
Query: 173 PLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLS 232
P+ + V+++ +L C G PV + W K + ++ +D + L I+ A+L
Sbjct: 461 PVNQTVAVDGTFVLSC-VATGSPVPTILWRK-DGVLVSTQDSRIKQLENGVLQIRYAKLG 518
Query: 233 DTANYTCVA 241
DT YTC+A
Sbjct: 519 DTGRYTCIA 527
>gi|116875765 tight junction protein 1 isoform b [Homo sapiens]
Length = 1668
Score = 78.6 bits (192), Expect = 3e-14
Identities = 45/95 (47%), Positives = 58/95 (61%), Gaps = 3/95 (3%)
Query: 531 TAFGSFNSLGGHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMD--DSQTLL 588
TA G FNS GG L +GVS++IP GAIP+G E+Y V R ++ PP+D +TLL
Sbjct: 1555 TARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETLL 1614
Query: 589 TPVVSCGPPGALLTRPVVLTMHHCADPNTEDWKIL 623
+P+V CGP G +PV L + HC DP T K L
Sbjct: 1615 SPLVMCGPHGLKFLKPVELRLPHC-DPKTWQNKCL 1648
>gi|116875767 tight junction protein 1 isoform a [Homo sapiens]
Length = 1748
Score = 78.6 bits (192), Expect = 3e-14
Identities = 45/95 (47%), Positives = 58/95 (61%), Gaps = 3/95 (3%)
Query: 531 TAFGSFNSLGGHLIVPNSGVSLLIPAGAIPQGRVYEMYVTVHRKETMRPPMD--DSQTLL 588
TA G FNS GG L +GVS++IP GAIP+G E+Y V R ++ PP+D +TLL
Sbjct: 1635 TARGIFNSNGGVLSSIETGVSIIIPQGAIPEGVEQEIYFKVCRDNSILPPLDKEKGETLL 1694
Query: 589 TPVVSCGPPGALLTRPVVLTMHHCADPNTEDWKIL 623
+P+V CGP G +PV L + HC DP T K L
Sbjct: 1695 SPLVMCGPHGLKFLKPVELRLPHC-DPKTWQNKCL 1728
>gi|224994173 roundabout 1 isoform d [Homo sapiens]
Length = 1551
Score = 78.2 bits (191), Expect = 3e-14
Identities = 62/226 (27%), Positives = 100/226 (44%), Gaps = 28/226 (12%)
Query: 36 TGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKAS--PATQIYF 93
+GS + +DF PP + H P + + K +P L CKA P I
Sbjct: 18 SGSRLRQEDF-----------PPRIVEH----PSDLIVSKGEPATLNCKAEGRPTPTI-- 60
Query: 94 KCNSEWVHQKDHIVDERVDETSG-LIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGT 152
EW + + ++ D S +++ S+ R P++ CVA + G
Sbjct: 61 ----EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGE 116
Query: 153 TKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVE 212
S A + +A LR F Q P V++ + +++C+PP G P + W K+ P++
Sbjct: 117 AVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDG---SPLD 173
Query: 213 DRNFYITI-DHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIV 257
D++ ITI L+I R SD Y CV N+V +R+S A + V
Sbjct: 174 DKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTV 219
Score = 49.3 bits (116), Expect = 2e-05
Identities = 35/115 (30%), Positives = 55/115 (47%), Gaps = 6/115 (5%)
Query: 144 CVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLK 203
CV + G +S A + + R +F + P V+++ +C G PV V W K
Sbjct: 201 CVGTNMVGERESEVAELTVLE-RPSFVKRPSNLAVTVDDSAEFKCEA-RGDPVPTVRWRK 258
Query: 204 NEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRK-STTATVIV 257
++ + + I DH L I++ D +YTCVA+N+V K + S T TV V
Sbjct: 259 DDG---ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV 310
Score = 41.2 bits (95), Expect = 0.005
Identities = 44/189 (23%), Positives = 79/189 (41%), Gaps = 21/189 (11%)
Query: 62 PHFLIEPEEAYIVKNKPVNLYCKAS--PATQIYFKC----NSEWVHQKDHIVDE-RVDET 114
PHF+++P + + + V C+A+ P I+++ N + +Q V +T
Sbjct: 315 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 374
Query: 115 SGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRK--TFEQE 172
L + V R V Y CQ + + + TK+ + R Q
Sbjct: 375 GDLTITNVQ----RSDVGY------YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG 424
Query: 173 PLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLS 232
P+ + V+++ +L C G PV + W K + ++ +D + L I+ A+L
Sbjct: 425 PVNQTVAVDGTFVLSC-VATGSPVPTILWRK-DGVLVSTQDSRIKQLENGVLQIRYAKLG 482
Query: 233 DTANYTCVA 241
DT YTC+A
Sbjct: 483 DTGRYTCIA 491
>gi|224994171 roundabout 1 isoform c [Homo sapiens]
Length = 1606
Score = 78.2 bits (191), Expect = 3e-14
Identities = 62/226 (27%), Positives = 100/226 (44%), Gaps = 28/226 (12%)
Query: 36 TGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKAS--PATQIYF 93
+GS + +DF PP + H P + + K +P L CKA P I
Sbjct: 18 SGSRLRQEDF-----------PPRIVEH----PSDLIVSKGEPATLNCKAEGRPTPTI-- 60
Query: 94 KCNSEWVHQKDHIVDERVDETSG-LIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGT 152
EW + + ++ D S +++ S+ R P++ CVA + G
Sbjct: 61 ----EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGE 116
Query: 153 TKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVE 212
S A + +A LR F Q P V++ + +++C+PP G P + W K+ P++
Sbjct: 117 AVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDG---SPLD 173
Query: 213 DRNFYITI-DHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIV 257
D++ ITI L+I R SD Y CV N+V +R+S A + V
Sbjct: 174 DKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTV 219
Score = 49.3 bits (116), Expect = 2e-05
Identities = 35/115 (30%), Positives = 55/115 (47%), Gaps = 6/115 (5%)
Query: 144 CVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLK 203
CV + G +S A + + R +F + P V+++ +C G PV V W K
Sbjct: 201 CVGTNMVGERESEVAELTVLE-RPSFVKRPSNLAVTVDDSAEFKCEA-RGDPVPTVRWRK 258
Query: 204 NEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRK-STTATVIV 257
++ + + I DH L I++ D +YTCVA+N+V K + S T TV V
Sbjct: 259 DDG---ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV 310
Score = 41.2 bits (95), Expect = 0.005
Identities = 44/189 (23%), Positives = 79/189 (41%), Gaps = 21/189 (11%)
Query: 62 PHFLIEPEEAYIVKNKPVNLYCKAS--PATQIYFKC----NSEWVHQKDHIVDE-RVDET 114
PHF+++P + + + V C+A+ P I+++ N + +Q V +T
Sbjct: 315 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 374
Query: 115 SGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRK--TFEQE 172
L + V R V Y CQ + + + TK+ + R Q
Sbjct: 375 GDLTITNVQ----RSDVGY------YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG 424
Query: 173 PLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLS 232
P+ + V+++ +L C G PV + W K + ++ +D + L I+ A+L
Sbjct: 425 PVNQTVAVDGTFVLSC-VATGSPVPTILWRK-DGVLVSTQDSRIKQLENGVLQIRYAKLG 482
Query: 233 DTANYTCVA 241
DT YTC+A
Sbjct: 483 DTGRYTCIA 491
>gi|19743806 roundabout 1 isoform b [Homo sapiens]
Length = 1612
Score = 78.2 bits (191), Expect = 3e-14
Identities = 62/226 (27%), Positives = 100/226 (44%), Gaps = 28/226 (12%)
Query: 36 TGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKAS--PATQIYF 93
+GS + +DF PP + H P + + K +P L CKA P I
Sbjct: 18 SGSRLRQEDF-----------PPRIVEH----PSDLIVSKGEPATLNCKAEGRPTPTI-- 60
Query: 94 KCNSEWVHQKDHIVDERVDETSG-LIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGT 152
EW + + ++ D S +++ S+ R P++ CVA + G
Sbjct: 61 ----EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGE 116
Query: 153 TKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVE 212
S A + +A LR F Q P V++ + +++C+PP G P + W K+ P++
Sbjct: 117 AVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDG---SPLD 173
Query: 213 DRNFYITI-DHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIV 257
D++ ITI L+I R SD Y CV N+V +R+S A + V
Sbjct: 174 DKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTV 219
Score = 48.9 bits (115), Expect = 2e-05
Identities = 34/113 (30%), Positives = 54/113 (47%), Gaps = 6/113 (5%)
Query: 144 CVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLK 203
CV + G +S A + + R +F + P V+++ +C G PV V W K
Sbjct: 201 CVGTNMVGERESEVAELTVLE-RPSFVKRPSNLAVTVDDSAEFKCEA-RGDPVPTVRWRK 258
Query: 204 NEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRK-STTATV 255
++ + + I DH L I++ D +YTCVA+N+V K + S T TV
Sbjct: 259 DDG---ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTV 308
Score = 41.2 bits (95), Expect = 0.005
Identities = 44/189 (23%), Positives = 79/189 (41%), Gaps = 21/189 (11%)
Query: 62 PHFLIEPEEAYIVKNKPVNLYCKAS--PATQIYFKC----NSEWVHQKDHIVDE-RVDET 114
PHF+++P + + + V C+A+ P I+++ N + +Q V +T
Sbjct: 312 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 371
Query: 115 SGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRK--TFEQE 172
L + V R V Y CQ + + + TK+ + R Q
Sbjct: 372 GDLTITNVQ----RSDVGY------YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG 421
Query: 173 PLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLS 232
P+ + V+++ +L C G PV + W K + ++ +D + L I+ A+L
Sbjct: 422 PVNQTVAVDGTFVLSC-VATGSPVPTILWRK-DGVLVSTQDSRIKQLENGVLQIRYAKLG 479
Query: 233 DTANYTCVA 241
DT YTC+A
Sbjct: 480 DTGRYTCIA 488
>gi|239748173 PREDICTED: similar to roundabout 1 isoform 1 [Homo
sapiens]
Length = 1562
Score = 78.2 bits (191), Expect = 3e-14
Identities = 62/226 (27%), Positives = 100/226 (44%), Gaps = 28/226 (12%)
Query: 36 TGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKAS--PATQIYF 93
+GS + +DF PP + H P + + K +P L CKA P I
Sbjct: 18 SGSRLRQEDF-----------PPRIVEH----PSDLIVSKGEPATLNCKAEGRPTPTI-- 60
Query: 94 KCNSEWVHQKDHIVDERVDETSG-LIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGT 152
EW + + ++ D S +++ S+ R P++ CVA + G
Sbjct: 61 ----EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGE 116
Query: 153 TKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVE 212
S A + +A LR F Q P V++ + +++C+PP G P + W K+ P++
Sbjct: 117 AVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDG---SPLD 173
Query: 213 DRNFYITI-DHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIV 257
D++ ITI L+I R SD Y CV N+V +R+S A + V
Sbjct: 174 DKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTV 219
Score = 49.3 bits (116), Expect = 2e-05
Identities = 35/115 (30%), Positives = 55/115 (47%), Gaps = 6/115 (5%)
Query: 144 CVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLK 203
CV + G +S A + + R +F + P V+++ +C G PV V W K
Sbjct: 201 CVGTNMVGERESEVAELTVLE-RPSFVKRPSNLAVTVDDSAEFKCEA-RGDPVPTVRWRK 258
Query: 204 NEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRK-STTATVIV 257
++ + + I DH L I++ D +YTCVA+N+V K + S T TV V
Sbjct: 259 DDG---ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV 310
Score = 41.2 bits (95), Expect = 0.005
Identities = 44/189 (23%), Positives = 79/189 (41%), Gaps = 21/189 (11%)
Query: 62 PHFLIEPEEAYIVKNKPVNLYCKAS--PATQIYFKC----NSEWVHQKDHIVDE-RVDET 114
PHF+++P + + + V C+A+ P I+++ N + +Q V +T
Sbjct: 315 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 374
Query: 115 SGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRK--TFEQE 172
L + V R V Y CQ + + + TK+ + R Q
Sbjct: 375 GDLTITNVQ----RSDVGY------YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG 424
Query: 173 PLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLS 232
P+ + V+++ +L C G PV + W K + ++ +D + L I+ A+L
Sbjct: 425 PVNQTVAVDGTFVLSC-VATGSPVPTILWRK-DGVLVSTQDSRIKQLENGVLQIRYAKLG 482
Query: 233 DTANYTCVA 241
DT YTC+A
Sbjct: 483 DTGRYTCIA 491
>gi|239748171 PREDICTED: similar to roundabout 1 isoform 2 [Homo
sapiens]
Length = 1615
Score = 78.2 bits (191), Expect = 3e-14
Identities = 62/226 (27%), Positives = 100/226 (44%), Gaps = 28/226 (12%)
Query: 36 TGSAAQDDDFFHELPETFPSDPPEPLPHFLIEPEEAYIVKNKPVNLYCKAS--PATQIYF 93
+GS + +DF PP + H P + + K +P L CKA P I
Sbjct: 18 SGSRLRQEDF-----------PPRIVEH----PSDLIVSKGEPATLNCKAEGRPTPTI-- 60
Query: 94 KCNSEWVHQKDHIVDERVDETSG-LIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGT 152
EW + + ++ D S +++ S+ R P++ CVA + G
Sbjct: 61 ----EWYKGGERVETDKDDPRSHRMLLPSGSLFFLRIVHGRKSRPDEGVYVCVARNYLGE 116
Query: 153 TKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVE 212
S A + +A LR F Q P V++ + +++C+PP G P + W K+ P++
Sbjct: 117 AVSHNASLEVAILRDDFRQNPSDVMVAVGEPAVMECQPPRGHPEPTISWKKDG---SPLD 173
Query: 213 DRNFYITI-DHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIV 257
D++ ITI L+I R SD Y CV N+V +R+S A + V
Sbjct: 174 DKDERITIRGGKLMITYTRKSDAGKYVCVGTNMVGERESEVAELTV 219
Score = 49.3 bits (116), Expect = 2e-05
Identities = 35/115 (30%), Positives = 55/115 (47%), Gaps = 6/115 (5%)
Query: 144 CVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLK 203
CV + G +S A + + R +F + P V+++ +C G PV V W K
Sbjct: 201 CVGTNMVGERESEVAELTVLE-RPSFVKRPSNLAVTVDDSAEFKCEA-RGDPVPTVRWRK 258
Query: 204 NEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRK-STTATVIV 257
++ + + I DH L I++ D +YTCVA+N+V K + S T TV V
Sbjct: 259 DDG---ELPKSRYEIRDDHTLKIRKVTAGDMGSYTCVAENMVGKAEASATLTVQV 310
Score = 41.2 bits (95), Expect = 0.005
Identities = 44/189 (23%), Positives = 79/189 (41%), Gaps = 21/189 (11%)
Query: 62 PHFLIEPEEAYIVKNKPVNLYCKAS--PATQIYFKC----NSEWVHQKDHIVDE-RVDET 114
PHF+++P + + + V C+A+ P I+++ N + +Q V +T
Sbjct: 315 PHFVVKPRDQVVALGRTVTFQCEATGNPQPAIFWRREGSQNLLFSYQPPQSSSRFSVSQT 374
Query: 115 SGLIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRK--TFEQE 172
L + V R V Y CQ + + + TK+ + R Q
Sbjct: 375 GDLTITNVQ----RSDVGY------YICQTLNVAGSIITKAYLEVTDVIADRPPPVIRQG 424
Query: 173 PLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQARLS 232
P+ + V+++ +L C G PV + W K + ++ +D + L I+ A+L
Sbjct: 425 PVNQTVAVDGTFVLSC-VATGSPVPTILWRK-DGVLVSTQDSRIKQLENGVLQIRYAKLG 482
Query: 233 DTANYTCVA 241
DT YTC+A
Sbjct: 483 DTGRYTCIA 491
>gi|48476182 roundabout, axon guidance receptor, homolog 3 [Homo
sapiens]
Length = 1386
Score = 76.6 bits (187), Expect = 1e-13
Identities = 56/203 (27%), Positives = 90/203 (44%), Gaps = 9/203 (4%)
Query: 57 PPEPLPHFLIEPEEAYIVKNKPVNLYCKASPATQIYFKCNSEWVHQKDHIVDERVDETSG 116
P + +P + +P + + + +P L C+A + N EW + R D +
Sbjct: 59 PEDAMPRIVEQPPDLLVSRGEPATLPCRAEGRP----RPNIEWYKNGARVATVREDPRAH 114
Query: 117 -LIVREVSIEISRQQVEELFGPEDYWCQCVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLG 175
L++ ++ R P++ CVA + G SR A + +A LR F Q P
Sbjct: 115 RLLLPSGALFFPRIVHGRRARPDEGVYTCVARNYLGAAASRNASLEVAVLRDDFRQSPGN 174
Query: 176 KEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITI-DHNLIIKQARLSDT 234
V++ + +L+C PP G P V W K+ + E R ITI L++ SD
Sbjct: 175 VVVAVGEPAVLECVPPRGHPEPSVSWRKDGARLKEEEGR---ITIRGGKLMMSHTLKSDA 231
Query: 235 ANYTCVAKNIVAKRKSTTATVIV 257
Y CVA N+ +R+S A V+V
Sbjct: 232 GMYVCVASNMAGERESAAAEVMV 254
Score = 43.9 bits (102), Expect = 7e-04
Identities = 31/108 (28%), Positives = 50/108 (46%), Gaps = 5/108 (4%)
Query: 144 CVAWSSAGTTKSRKAYVRIAYLRKTFEQEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLK 203
CVA + AG +S A V + R +F + P+ + V + V C +G P + W K
Sbjct: 236 CVASNMAGERESAAAEVMVLE-RPSFLRRPVNQVVLADAPVTFLCEV-KGDPPPRLRWRK 293
Query: 204 NEDIIDPVEDRNFYITIDHNLIIKQARLSDTANYTCVAKNIVAKRKST 251
+ + + I DH+L I D YTCVA+N V + +++
Sbjct: 294 EDG---ELPTGRYEIRSDHSLWIGHVSAEDEGTYTCVAENSVGRAEAS 338
Score = 31.2 bits (69), Expect = 4.7
Identities = 30/101 (29%), Positives = 43/101 (42%), Gaps = 17/101 (16%)
Query: 171 QEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRN------------FYI 218
++P VS + L CR EG P +EW KN + V + F+
Sbjct: 68 EQPPDLLVSRGEPATLPCRA-EGRPRPNIEWYKNGARVATVREDPRAHRLLLPSGALFFP 126
Query: 219 TIDHNLIIKQARLSDTANYTCVAKNIVAKRKSTTATVIVYV 259
I H ++AR D YTCVA+N + S A++ V V
Sbjct: 127 RIVHG---RRAR-PDEGVYTCVARNYLGAAASRNASLEVAV 163
Score = 30.4 bits (67), Expect = 8.0
Identities = 26/99 (26%), Positives = 38/99 (38%), Gaps = 18/99 (18%)
Query: 171 QEPLGKEVSLEQEVLLQCRPPEGIPVAEVEWLKNEDIIDPVEDRNFYITIDHNLIIKQAR 230
Q P + + L V L CR G P V W K+ + +D F + L I +
Sbjct: 455 QGPANQTLVLGSSVWLPCRVT-GNPQPSVRWKKDGQWLQG-DDLQFKTMANGTLYIANVQ 512
Query: 231 LSDTANYTCVAKNIVAKRKSTTATVIVYVNGGWSTWTEW 269
D Y+CVAK+ + G +TW+ W
Sbjct: 513 EMDMGFYSCVAKS----------------STGEATWSGW 535
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1
motif, 16 preproprotein [Homo sapiens]
Length = 1224
Score = 64.7 bits (156), Expect = 4e-10
Identities = 27/58 (46%), Positives = 35/58 (60%), Gaps = 1/58 (1%)
Query: 260 NGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQS-VQKIACTTLCPVD 316
+G WS W+ WS C+ CG G R+R CTNP P +GG FCEG + K+ + CP D
Sbjct: 586 HGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRD 643
Score = 54.3 bits (129), Expect = 5e-07
Identities = 27/79 (34%), Positives = 33/79 (41%), Gaps = 3/79 (3%)
Query: 298 FCEGQSVQKIACTTLCPVDGRWTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDG 354
+C G K P G W+ WS WS C C R R CT P P +GGK C+G
Sbjct: 568 WCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCGGGVSHRSRLCTNPKPSHGGKFCEG 627
Query: 355 LVLQSKNCTDGLCMQTAPD 373
K C C + + D
Sbjct: 628 STRTLKLCNSQKCPRDSVD 646
Score = 36.6 bits (83), Expect = 0.11
Identities = 35/126 (27%), Positives = 50/126 (39%), Gaps = 15/126 (11%)
Query: 247 KRKSTTATVIVYVNGGWSTWT--EWSVCNSRCGRGYQKRTRTCT-----NPAPLNGGAFC 299
K + T V V+ +W+ WS C+ CG G Q R CT + P+
Sbjct: 912 KTRPVTGLVPCKVSACPPSWSVGNWSACSRTCGGGAQSRPVQCTRRVHYDSEPVPASLCP 971
Query: 300 EGQSVQKIACTT-LCPVDGRWTPWSKWS-TCGTECTHWRRRECTAPAPKNGGKDCDGLVL 357
+ + AC + CP PW++ S TCG WR+R A A K+ +L
Sbjct: 972 QPAPSSRQACNSQSCPPAWSAGPWAECSHTCG---KGWRKR---AVACKSTNPSARAQLL 1025
Query: 358 QSKNCT 363
CT
Sbjct: 1026 PDAVCT 1031
Score = 34.7 bits (78), Expect = 0.42
Identities = 31/105 (29%), Positives = 44/105 (41%), Gaps = 13/105 (12%)
Query: 269 WSVCNSRCGRGYQKRTRTC--TNP---APLNGGAFCEGQSVQKI--ACTTLCPVDGRWTP 321
W+ C+ CG+G++KR C TNP A L A C + ++ AC +
Sbjct: 995 WAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHKPKKLQ 1054
Query: 322 W--SKWSTCGTECTHWRRRECTAPAPKN-GGKDCDGLVLQSKNCT 363
W S WS C C ++ A K GK + L SK C+
Sbjct: 1055 WLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRE---LASKKCS 1096
Score = 32.7 bits (73), Expect = 1.6
Identities = 17/56 (30%), Positives = 23/56 (41%), Gaps = 2/56 (3%)
Query: 261 GGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTT-LCPV 315
G W + WS C + CG G Q R+ C G + +AC T CP+
Sbjct: 1128 GSWFA-SPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQKPSASLACNTHFCPI 1182
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1
motif, 17 preproprotein [Homo sapiens]
Length = 1095
Score = 62.8 bits (151), Expect = 1e-09
Identities = 27/58 (46%), Positives = 33/58 (56%), Gaps = 1/58 (1%)
Query: 258 YVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTL-CP 314
+V+G WS W WS+C+ CG G + R R C NP P GG C G SV+ C L CP
Sbjct: 541 HVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCP 598
Score = 51.6 bits (122), Expect = 3e-06
Identities = 23/65 (35%), Positives = 31/65 (47%), Gaps = 3/65 (4%)
Query: 315 VDGRWTPWSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDGLVLQSKNCTDGLCMQTA 371
VDG W+PW WS C C +R+R+C P P GG C G ++ C + C +
Sbjct: 542 VDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHAVCENLPCPKGL 601
Query: 372 PDSDD 376
P D
Sbjct: 602 PSFRD 606
Score = 38.5 bits (88), Expect = 0.029
Identities = 29/97 (29%), Positives = 38/97 (39%), Gaps = 10/97 (10%)
Query: 264 STW--TEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIACTTLCPVDGRWTP 321
S W +EWS C++ CG+G KRT CTN G + + AC W
Sbjct: 923 SIWEASEWSQCSASCGKGVWKRTVACTNS---QGKCDASTRPRAEEACEDYSGC-YEWKT 978
Query: 322 WSKWSTCGTEC---THWRRRECTAPAPKNGGKDCDGL 355
WSTC + C R +C G +C L
Sbjct: 979 -GDWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPAL 1014
Score = 33.5 bits (75), Expect = 0.95
Identities = 15/41 (36%), Positives = 20/41 (48%), Gaps = 1/41 (2%)
Query: 263 WSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQS 303
W T +WS C+S CG+G Q R C + G+ C S
Sbjct: 976 WKTG-DWSTCSSTCGKGLQSRVVQCMHKVTGRHGSECPALS 1015
Score = 33.1 bits (74), Expect = 1.2
Identities = 28/96 (29%), Positives = 38/96 (39%), Gaps = 20/96 (20%)
Query: 269 WSVCNSRCGRGYQKRTRTCTNPAPLNGGA-------FCEGQSVQKIACTTLCPVDGRWTP 321
WS C++ C +G+Q R TC L G +C G + A C +
Sbjct: 870 WSPCSATCEKGFQHREVTCV--YQLQNGTHVATRPLYCPG---PRPAAVQSCEGQDCLSI 924
Query: 322 W--SKWSTCGTECTH--WRRRECTAPAPKNGGKDCD 353
W S+WS C C W+R T + GK CD
Sbjct: 925 WEASEWSQCSASCGKGVWKR---TVACTNSQGK-CD 956
>gi|4557389 complement component 8, alpha polypeptide precursor
[Homo sapiens]
Length = 584
Score = 62.4 bits (150), Expect = 2e-09
Identities = 29/58 (50%), Positives = 34/58 (58%), Gaps = 4/58 (6%)
Query: 252 TATVIVYVNGGWSTWTEWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQSVQKIAC 309
T T +G WS W+ WSVC + G Q+R R C NPAP NGGA C G+ VQ AC
Sbjct: 531 TQTEGAKADGSWSCWSSWSVCRA----GIQERRRECDNPAPQNGGASCPGRKVQTQAC 584
Score = 54.7 bits (130), Expect = 4e-07
Identities = 36/102 (35%), Positives = 45/102 (44%), Gaps = 17/102 (16%)
Query: 268 EWSVCNSRCGRGYQKRTRTCTNPAPLNGGAFCEGQ---SVQKIAC----TTLCPVDGRWT 320
E++ C RCG + N P+ G C Q AC T DG W+
Sbjct: 493 EFNAC--RCGPCFN-------NGVPILEGTSCRCQCRLGSLGAACEQTQTEGAKADGSWS 543
Query: 321 PWSKWSTCGTECTHWRRRECTAPAPKNGGKDCDGLVLQSKNC 362
WS WS C RRREC PAP+NGG C G +Q++ C
Sbjct: 544 CWSSWSVCRAGIQE-RRRECDNPAPQNGGASCPGRKVQTQAC 584
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.319 0.134 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 39,126,763
Number of Sequences: 37866
Number of extensions: 1928072
Number of successful extensions: 6212
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 112
Number of HSP's successfully gapped in prelim test: 139
Number of HSP's that attempted gapping in prelim test: 4912
Number of HSP's gapped (non-prelim): 1121
length of query: 931
length of database: 18,247,518
effective HSP length: 112
effective length of query: 819
effective length of database: 14,006,526
effective search space: 11471344794
effective search space used: 11471344794
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.