Guide to the Human Genome
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Search of human proteins with 112382222

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|112382222 chloride channel Ka isoform 2 [Homo sapiens]
         (686 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|112382222 chloride channel Ka isoform 2 [Homo sapiens]            1374   0.0  
gi|112382220 chloride channel Ka isoform 1 [Homo sapiens]            1370   0.0  
gi|155969705 chloride channel Kb [Homo sapiens]                      1260   0.0  
gi|156104869 chloride channel 2 [Homo sapiens]                        541   e-154
gi|119433677 chloride channel 1, skeletal muscle [Homo sapiens]       490   e-138
gi|153252026 chloride channel 4 [Homo sapiens]                        194   2e-49
gi|189217923 chloride channel 5 isoform a [Homo sapiens]              186   5e-47
gi|189217921 chloride channel 5 isoform a [Homo sapiens]              186   5e-47
gi|4557473 chloride channel 5 isoform b [Homo sapiens]                186   5e-47
gi|55770838 chloride channel 3 isoform b [Homo sapiens]               179   6e-45
gi|55770840 chloride channel 3 isoform e [Homo sapiens]               176   8e-44
gi|167466160 chloride channel 7 isoform b [Homo sapiens]              146   5e-35
gi|14149607 chloride channel 7 isoform a [Homo sapiens]               146   5e-35
gi|4502873 chloride channel 6 isoform ClC-6a [Homo sapiens]           119   7e-27
gi|12025671 chloride channel 6 isoform ClC-6c [Homo sapiens]           73   1e-12
gi|12025673 chloride channel 6 isoform ClC-6d [Homo sapiens]           48   3e-05
gi|12025668 chloride channel 6 isoform ClC-6b [Homo sapiens]           48   3e-05
gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]       31   3.3  
gi|126352608 elastin isoform e precursor [Homo sapiens]                31   4.4  
gi|126352446 elastin isoform d precursor [Homo sapiens]                31   4.4  
gi|126352322 elastin isoform c precursor [Homo sapiens]                31   4.4  
gi|126352700 elastin isoform b precursor [Homo sapiens]                31   4.4  
gi|126352440 elastin isoform a precursor [Homo sapiens]                31   4.4  
gi|156938237 ADP-ribosylation factor-like 17 isoform a [Homo sap...    31   4.4  
gi|166063999 hypothetical protein LOC51326 isoform a [Homo sapiens]    31   4.4  
gi|48255947 plasma membrane calcium ATPase 1 isoform 1a [Homo sa...    30   9.7  
gi|48255945 plasma membrane calcium ATPase 1 isoform 1b [Homo sa...    30   9.7  
gi|84508631 phosphatidylglycerophosphate synthase 1 [Homo sapiens]     30   9.7  
gi|41349446 stromal interaction molecule 2 [Homo sapiens]              30   9.7  

>gi|112382222 chloride channel Ka isoform 2 [Homo sapiens]
          Length = 686

 Score = 1374 bits (3557), Expect = 0.0
 Identities = 686/686 (100%), Positives = 686/686 (100%)

Query: 1   MEELVGLREGFSGDPVTLQELWGPCPHIRRAIQGGLEWLKQKVFRLGEDWYFLMTLGVLM 60
           MEELVGLREGFSGDPVTLQELWGPCPHIRRAIQGGLEWLKQKVFRLGEDWYFLMTLGVLM
Sbjct: 1   MEELVGLREGFSGDPVTLQELWGPCPHIRRAIQGGLEWLKQKVFRLGEDWYFLMTLGVLM 60

Query: 61  ALVSYAMNFAIGCVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGG 120
           ALVSYAMNFAIGCVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGG
Sbjct: 61  ALVSYAMNFAIGCVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGG 120

Query: 121 SGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYL 180
           SGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYL
Sbjct: 121 SGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYL 180

Query: 181 GRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGF 240
           GRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGF
Sbjct: 181 GRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGF 240

Query: 241 FAATCGAFIFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYL 300
           FAATCGAFIFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYL
Sbjct: 241 FAATCGAFIFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYL 300

Query: 301 FCQRTFLSFIKTNRYSSKLLATSKPVYSALATLLLASITYPPGVGHFLASRLSMKQHLDS 360
           FCQRTFLSFIKTNRYSSKLLATSKPVYSALATLLLASITYPPGVGHFLASRLSMKQHLDS
Sbjct: 301 FCQRTFLSFIKTNRYSSKLLATSKPVYSALATLLLASITYPPGVGHFLASRLSMKQHLDS 360

Query: 361 LFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIP 420
           LFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIP
Sbjct: 361 LFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIP 420

Query: 421 MPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTH 480
           MPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTH
Sbjct: 421 MPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTH 480

Query: 481 TISTALLAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNI 540
           TISTALLAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNI
Sbjct: 481 TISTALLAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNI 540

Query: 541 GSHHVRVEHFMNHSITTLAKDTPLEEVVKVVTSTDVTEYPLVESTESQILVGIVQRAQLV 600
           GSHHVRVEHFMNHSITTLAKDTPLEEVVKVVTSTDVTEYPLVESTESQILVGIVQRAQLV
Sbjct: 541 GSHHVRVEHFMNHSITTLAKDTPLEEVVKVVTSTDVTEYPLVESTESQILVGIVQRAQLV 600

Query: 601 QALQAEPPSRAPGHQCLQDILARGCPTEPVTLTLFSETTLHQAQNLFKLLNLQSLFVTSR 660
           QALQAEPPSRAPGHQCLQDILARGCPTEPVTLTLFSETTLHQAQNLFKLLNLQSLFVTSR
Sbjct: 601 QALQAEPPSRAPGHQCLQDILARGCPTEPVTLTLFSETTLHQAQNLFKLLNLQSLFVTSR 660

Query: 661 GRAVGCVSWVEMKKAISNLTNPPAPK 686
           GRAVGCVSWVEMKKAISNLTNPPAPK
Sbjct: 661 GRAVGCVSWVEMKKAISNLTNPPAPK 686


>gi|112382220 chloride channel Ka isoform 1 [Homo sapiens]
          Length = 687

 Score = 1370 bits (3545), Expect = 0.0
 Identities = 686/687 (99%), Positives = 686/687 (99%), Gaps = 1/687 (0%)

Query: 1   MEELVGLREGFSGDPVTLQELWGPCPHIRRAIQGGLEWLKQKVFRLGEDWYFLMTLGVLM 60
           MEELVGLREGFSGDPVTLQELWGPCPHIRRAIQGGLEWLKQKVFRLGEDWYFLMTLGVLM
Sbjct: 1   MEELVGLREGFSGDPVTLQELWGPCPHIRRAIQGGLEWLKQKVFRLGEDWYFLMTLGVLM 60

Query: 61  ALVSYAMNFAIGCVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGG 120
           ALVSYAMNFAIGCVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGG
Sbjct: 61  ALVSYAMNFAIGCVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGG 120

Query: 121 SGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYL 180
           SGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYL
Sbjct: 121 SGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYL 180

Query: 181 GRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGF 240
           GRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGF
Sbjct: 181 GRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGF 240

Query: 241 FAATCGAFIFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYL 300
           FAATCGAFIFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYL
Sbjct: 241 FAATCGAFIFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYL 300

Query: 301 FCQRTFLSFIKTNRYSSKLLATSKPVYSALATLLLASITYPPGVGHFLASRLSMKQHLDS 360
           FCQRTFLSFIKTNRYSSKLLATSKPVYSALATLLLASITYPPGVGHFLASRLSMKQHLDS
Sbjct: 301 FCQRTFLSFIKTNRYSSKLLATSKPVYSALATLLLASITYPPGVGHFLASRLSMKQHLDS 360

Query: 361 LFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIP 420
           LFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIP
Sbjct: 361 LFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIP 420

Query: 421 MPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTH 480
           MPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTH
Sbjct: 421 MPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTH 480

Query: 481 TISTALLAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNI 540
           TISTALLAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNI
Sbjct: 481 TISTALLAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNI 540

Query: 541 GSHHVRVEHFMNHSITTLAKDTPLEEVVKVVTSTDVTEYPLVESTESQILVGIVQRAQLV 600
           GSHHVRVEHFMNHSITTLAKDTPLEEVVKVVTSTDVTEYPLVESTESQILVGIVQRAQLV
Sbjct: 541 GSHHVRVEHFMNHSITTLAKDTPLEEVVKVVTSTDVTEYPLVESTESQILVGIVQRAQLV 600

Query: 601 QALQAEPPSRAPGH-QCLQDILARGCPTEPVTLTLFSETTLHQAQNLFKLLNLQSLFVTS 659
           QALQAEPPSRAPGH QCLQDILARGCPTEPVTLTLFSETTLHQAQNLFKLLNLQSLFVTS
Sbjct: 601 QALQAEPPSRAPGHQQCLQDILARGCPTEPVTLTLFSETTLHQAQNLFKLLNLQSLFVTS 660

Query: 660 RGRAVGCVSWVEMKKAISNLTNPPAPK 686
           RGRAVGCVSWVEMKKAISNLTNPPAPK
Sbjct: 661 RGRAVGCVSWVEMKKAISNLTNPPAPK 687


>gi|155969705 chloride channel Kb [Homo sapiens]
          Length = 687

 Score = 1260 bits (3260), Expect = 0.0
 Identities = 626/687 (91%), Positives = 651/687 (94%), Gaps = 1/687 (0%)

Query: 1   MEELVGLREGFSGDPVTLQELWGPCPHIRRAIQGGLEWLKQKVFRLGEDWYFLMTLGVLM 60
           MEE VGLREG SG+PVTLQELWGPCP IRR I+GGLEWLKQK+FRLGEDWYFLMTLGVLM
Sbjct: 1   MEEFVGLREGSSGNPVTLQELWGPCPRIRRGIRGGLEWLKQKLFRLGEDWYFLMTLGVLM 60

Query: 61  ALVSYAMNFAIGCVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGG 120
           ALVS AM+ A+  VVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGG
Sbjct: 61  ALVSCAMDLAVESVVRAHQWLYREIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGG 120

Query: 121 SGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYL 180
           SGIPE+KTMLAGV+LEDYLDIKNFGAKVVGLSCTLA GSTLFLGKVGPFVHLSVM+AAYL
Sbjct: 121 SGIPEVKTMLAGVVLEDYLDIKNFGAKVVGLSCTLACGSTLFLGKVGPFVHLSVMMAAYL 180

Query: 181 GRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGF 240
           GRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSV DYWRGF
Sbjct: 181 GRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVWDYWRGF 240

Query: 241 FAATCGAFIFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYL 300
           FAATCGAF+FRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGG+CG+L  AYL
Sbjct: 241 FAATCGAFMFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGLCGILGSAYL 300

Query: 301 FCQRTFLSFIKTNRYSSKLLATSKPVYSALATLLLASITYPPGVGHFLASRLSMKQHLDS 360
           FCQR F  FI+ NR+SSKLLATSKPVYSALATL+LASITYPP  G FLASRLSMKQHLDS
Sbjct: 301 FCQRIFFGFIRNNRFSSKLLATSKPVYSALATLVLASITYPPSAGRFLASRLSMKQHLDS 360

Query: 361 LFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIP 420
           LFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIP
Sbjct: 361 LFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIP 420

Query: 421 MPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTH 480
           MPAGYFMPIF+ GAAIGRL GE L+  FPEGIV GG+TNPIMPGGYALAGAAAFSGAVTH
Sbjct: 421 MPAGYFMPIFVYGAAIGRLFGETLSFIFPEGIVAGGITNPIMPGGYALAGAAAFSGAVTH 480

Query: 481 TISTALLAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNI 540
           TISTALLAFE+TGQIVHALPVLMAVLAANAIAQSCQPSFYDGT+IVKKLPYLPRILGRNI
Sbjct: 481 TISTALLAFEVTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTVIVKKLPYLPRILGRNI 540

Query: 541 GSHHVRVEHFMNHSITTLAKDTPLEEVVKVVTSTDVTEYPLVESTESQILVGIVQRAQLV 600
           GSH VRVEHFMNHSITTLAKD PLEEVVKVVTSTDV +YPLVESTESQILVGIV+RAQLV
Sbjct: 541 GSHRVRVEHFMNHSITTLAKDMPLEEVVKVVTSTDVAKYPLVESTESQILVGIVRRAQLV 600

Query: 601 QALQAEPPSRAPGH-QCLQDILARGCPTEPVTLTLFSETTLHQAQNLFKLLNLQSLFVTS 659
           QAL+AEPPS APGH QCLQDILA GCPTEPVTL L  ET+LH+A NLF+LLNL SLFVTS
Sbjct: 601 QALKAEPPSWAPGHQQCLQDILAAGCPTEPVTLKLSPETSLHEAHNLFELLNLHSLFVTS 660

Query: 660 RGRAVGCVSWVEMKKAISNLTNPPAPK 686
           RGRAVGCVSWVEMKKAISNLTNPPAPK
Sbjct: 661 RGRAVGCVSWVEMKKAISNLTNPPAPK 687


>gi|156104869 chloride channel 2 [Homo sapiens]
          Length = 898

 Score =  541 bits (1395), Expect = e-154
 Identities = 282/573 (49%), Positives = 386/573 (67%), Gaps = 9/573 (1%)

Query: 43  VFRLGEDWYFLMTLGVLMALVSYAMNFAIGCVVRAHQWLYREIGDSHLLRYLSWTVYPVA 102
           V R+GEDW FL+ LG+LMALVS+ M++AI   ++A QW+ R +  S LL+YL+W  YPV 
Sbjct: 84  VSRVGEDWIFLVLLGLLMALVSWVMDYAIAACLQAQQWMSRGLNTSILLQYLAWVTYPVV 143

Query: 103 LVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLF 162
           L++FS+GF+Q + P + GSGIPE+KT+L GV+L++YL +K F AKV+GL+C L  GS + 
Sbjct: 144 LITFSAGFTQILAPQAVGSGIPEMKTILRGVVLKEYLTLKTFIAKVIGLTCAL--GSGMP 201

Query: 163 LGKVGPFVHLSVMIAAYLGRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLF 222
           LGK GPFVH++ M AA L +  +   G  EN+S+  EML AA AVGV   FAAP  GVLF
Sbjct: 202 LGKEGPFVHIASMCAALLSKFLSLFGGIYENESRNTEMLAAACAVGVGCCFAAPIGGVLF 261

Query: 223 SIEVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEI 282
           SIEV S+ F+VR+YWRGFFAAT  AFIFR+LAV+N ++ETIT+L+KT FR+D PFDL E+
Sbjct: 262 SIEVTSTFFAVRNYWRGFFAATFSAFIFRVLAVWNRDEETITALFKTRFRLDFPFDLQEL 321

Query: 283 FFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYSALATLLLASITYPP 342
             F  +G   G     +++  R  +  ++  +  ++ L   + ++ AL TLL++++T+PP
Sbjct: 322 PAFAVIGIASGFGGALFVYLNRKIVQVMRKQKTINRFLMRKRLLFPALVTLLISTLTFPP 381

Query: 343 GVGHFLASRLSMKQHLDSLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTL 402
           G G F+A +LS K+ L +LFDN +W            EEL+P      W  PR  +F TL
Sbjct: 382 GFGQFMAGQLSQKETLVTLFDNRTWVRQGL------VEELEPPSTSQAWNPPRANVFLTL 435

Query: 403 AFFLVMKFWMLILATTIPMPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIM 462
             F++MKFWM  LATTIP+P G FMP+F++GAA GRL+GE++A  FP+GI T   T  I+
Sbjct: 436 VIFILMKFWMSALATTIPVPCGAFMPVFVIGAAFGRLVGESMAAWFPDGIHTDSSTYRIV 495

Query: 463 PGGYALAGAAAFSGAVTHTISTALLAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDG 522
           PGGYA+ GAAA +GAVTHT+STA++ FELTGQI H LPV++AV+ ANA+AQS QPS YD 
Sbjct: 496 PGGYAVVGAAALAGAVTHTVSTAVIVFELTGQIAHILPVMIAVILANAVAQSLQPSLYDS 555

Query: 523 TIIVKKLPYLPRILGRNIGSHHVRVEHFMNHSITTLAKDTPLEEVVKVVTSTDVTEYPLV 582
            I +KKLPYLP +       + VRVE  M   +  +A      ++   +  T      LV
Sbjct: 556 IIRIKKLPYLPELGWGRHQQYRVRVEDIMVRDVPHVALSCTFRDLRLALHRTKGRMLALV 615

Query: 583 ESTESQILVGIVQRAQLVQALQAE-PPSRAPGH 614
           ES ES IL+G ++R+Q+V  L A+  P+R   H
Sbjct: 616 ESPESMILLGSIERSQVVALLGAQLSPARRRQH 648



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 20/52 (38%), Positives = 30/52 (57%)

Query: 625 CPTEPVTLTLFSETTLHQAQNLFKLLNLQSLFVTSRGRAVGCVSWVEMKKAI 676
           C  +P    L   T+LH+   +F LL +   +VTS GR +G V+  E++KAI
Sbjct: 788 CKIDPAPFQLVERTSLHKTHTIFSLLGVDHAYVTSIGRLIGIVTLKELRKAI 839


>gi|119433677 chloride channel 1, skeletal muscle [Homo sapiens]
          Length = 988

 Score =  490 bits (1262), Expect = e-138
 Identities = 249/560 (44%), Positives = 370/560 (66%), Gaps = 10/560 (1%)

Query: 45  RLGEDWYFLMTLGVLMALVSYAMNFAIGCVVRAHQWLYREIGDSHLLRYLSWTVYPVALV 104
           +LGEDW FL+ LG+LMALVS++M++     ++A++W Y ++  S  L++L W  +P+ L+
Sbjct: 113 KLGEDWIFLVLLGLLMALVSWSMDYVSAKSLQAYKWSYAQMQPSLPLQFLVWVTFPLVLI 172

Query: 105 SFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLG 164
            FS+ F   I+P + GSGIPE+KT+L GV+L++YL +K F AKVV L+  L  GS + +G
Sbjct: 173 LFSALFCHLISPQAVGSGIPEMKTILRGVVLKEYLTMKAFVAKVVALTAGL--GSGIPVG 230

Query: 165 KVGPFVHLSVMIAAYLGRVRTTTIGEPENKSKQNEMLVAAAAVGVATVFAAPFSGVLFSI 224
           K GPFVH++ + AA L +  +   G  E     +++L    AVGV   F  P  GVLFSI
Sbjct: 231 KEGPFVHIASICAAVLSKFMSVFCGVYEQPYYYSDILTVGCAVGVGCCFGTPLGGVLFSI 290

Query: 225 EVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFF 284
           EV S++F+VR+YWRGFFAAT  AF+FR+LAV+N +  TIT+L++T+FR+D PFDL E+  
Sbjct: 291 EVTSTYFAVRNYWRGFFAATFSAFVFRVLAVWNKDAVTITALFRTNFRMDFPFDLKELPA 350

Query: 285 FVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYSALATLLLASITYPPGV 344
           F A+G  CG+L   +++  R  +  ++ ++  S+ LA  + +Y  + T ++AS T+PPG+
Sbjct: 351 FAAIGICCGLLGAVFVYLHRQVMLGVRKHKALSQFLAKHRLLYPGIVTFVIASFTFPPGM 410

Query: 345 GHFLASRLSMKQHLDSLFDNHSWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAF 404
           G F+A  L  ++ + +LFDN++W     +     PE L    +W    HPR  +   +  
Sbjct: 411 GQFMAGELMPREAISTLFDNNTWVKHAGD-----PESLGQSAVW---IHPRVNVVIIIFL 462

Query: 405 FLVMKFWMLILATTIPMPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPG 464
           F VMKFWM I+ATT+P+P G FMP+F+LGAA GRL+GE +A+ FP+GI+   +   I+PG
Sbjct: 463 FFVMKFWMSIVATTMPIPCGGFMPVFVLGAAFGRLVGEIMAMLFPDGILFDDIIYKILPG 522

Query: 465 GYALAGAAAFSGAVTHTISTALLAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTI 524
           GYA+ GAAA +GAV+HT+STA++ FELTGQI H LP+++AV+ AN +AQS QPS YD  I
Sbjct: 523 GYAVIGAAALTGAVSHTVSTAVICFELTGQIAHILPMMVAVILANMVAQSLQPSLYDSII 582

Query: 525 IVKKLPYLPRILGRNIGSHHVRVEHFMNHSITTLAKDTPLEEVVKVVTSTDVTEYPLVES 584
            VKKLPYLP +    +  + + VE  M   +  ++      E+  ++ +T V   PLV+S
Sbjct: 583 QVKKLPYLPDLGWNQLSKYTIFVEDIMVRDVKFVSASYTYGELRTLLQTTTVKTLPLVDS 642

Query: 585 TESQILVGIVQRAQLVQALQ 604
            +S IL+G V+R++L   LQ
Sbjct: 643 KDSMILLGSVERSELQALLQ 662



 Score = 42.7 bits (99), Expect = 0.001
 Identities = 26/82 (31%), Positives = 37/82 (45%)

Query: 599 LVQALQAEPPSRAPGHQCLQDILARGCPTEPVTLTLFSETTLHQAQNLFKLLNLQSLFVT 658
           LV  +  E        Q  Q +    C  +     L  +TTLH+   LF LL L   +VT
Sbjct: 793 LVDNMSPEEIEAWEQEQLSQPVCFDSCCIDQSPFQLVEQTTLHKTHTLFSLLGLHLAYVT 852

Query: 659 SRGRAVGCVSWVEMKKAISNLT 680
           S G+  G ++  E++KAI   T
Sbjct: 853 SMGKLRGVLALEELQKAIEGHT 874


>gi|153252026 chloride channel 4 [Homo sapiens]
          Length = 760

 Score =  194 bits (494), Expect = 2e-49
 Identities = 170/638 (26%), Positives = 289/638 (45%), Gaps = 70/638 (10%)

Query: 84  EIGDSHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKN 143
           E   +++L YL + ++ +     +    +   P + GSGIPE+KT+L+G I+  YL    
Sbjct: 144 EGASAYILNYLMYILWALLFAFLAVSLVRVFAPYACGSGIPEIKTILSGFIIRGYLGKWT 203

Query: 144 FGAKVVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYLGRVRTTTIGEPENKSKQNEMLVA 203
              K V L   +++G  L LGK GP VH++     +   + +      +N+ K+ E+L A
Sbjct: 204 LLIKTVTLVLVVSSG--LSLGKEGPLVHVACCCGNFFSSLFSKY---SKNEGKRREVLSA 258

Query: 204 AAAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETI 263
           AAA GV+  F AP  GVLFS+E +S +F ++  WR FFAA   AF  R +  F + +   
Sbjct: 259 AAAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSR--- 315

Query: 264 TSLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATS 323
             L         P+ + E+F F+ LG   G+    ++ C   +    KT R         
Sbjct: 316 --LVLFYVEYHTPWYMAELFPFILLGVFGGLWGTLFIRCNIAWCRRRKTTRLG------K 367

Query: 324 KPVYSAL-ATLLLASITYPPGVGHFLASRLSMKQHLDSLFDN----HSWALMTQNSSPPW 378
            PV   +  T + A I YP        +R S  + +  LF++     S  L    + P  
Sbjct: 368 YPVLEVIVVTAITAIIAYPNPY-----TRQSTSELISELFNDCGALESSQLCDYINDPNM 422

Query: 379 PEELD-----PQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFILG 433
              +D     P  +        +T    LA  L+ K  + I    + +P+G F+P   +G
Sbjct: 423 TRPVDDIPDRPAGV------GVYTAMWQLALALIFKIVVTIFTFGMKIPSGLFIPSMAVG 476

Query: 434 AAIGRLLG---EALAVAFPEGIVTGGVTNP----IMPGGYALAGAAAFSGAVTH-TISTA 485
           A  GR++G   E LA    + I+      P    + PG YA+ GAAA  G VT  T+S  
Sbjct: 477 AIAGRMVGIGVEQLAYHHHDWIIFRNWCRPGADCVTPGLYAMVGAAACLGGVTRMTVSLV 536

Query: 486 LLAFELTGQIVHALPVLMAVLAANAIAQSC-QPSFYDGTIIVKKLPYL---PRILGRNIG 541
           ++ FELTG + + +P++ A + +  +A +  +   Y+  I +   P+L        R + 
Sbjct: 537 VIMFELTGGLEYIVPLMAAAVTSKWVADAFGKEGIYEAHIHLNGYPFLDVKDEFTHRTLA 596

Query: 542 SHHVRVEHFMNHSITTLAKDT-PLEEVVKVVTSTDVTEYPLVESTESQILVGIVQRAQLV 600
           +  +R        ++ L +D+  +E+V  ++  TD   +P+V S +S+ L+G  QR +L+
Sbjct: 597 TDVMRPRR-GEPPLSVLTQDSMTVEDVETLIKETDYNGFPVVVSRDSERLIGFAQRRELI 655

Query: 601 QALQ-----------------AEPPSRAPGHQCLQDILARGCPTEPVTLTLFSETTLHQA 643
            A++                  E P   P +      L R     P T+T    T +   
Sbjct: 656 LAIKNARQRQEGIVSNSIMYFTEEPPELPANSPHPLKLRRILNLSPFTVT--DHTPMETV 713

Query: 644 QNLFKLLNLQSLFVTSRGRAVGCVSWVEMKKAISNLTN 681
            ++F+ L L+   VT  GR +G ++  ++ + ++ + N
Sbjct: 714 VDIFRKLGLRQCLVTRSGRLLGIITKKDVLRHMAQMAN 751


>gi|189217923 chloride channel 5 isoform a [Homo sapiens]
          Length = 816

 Score =  186 bits (473), Expect = 5e-47
 Identities = 179/652 (27%), Positives = 293/652 (44%), Gaps = 107/652 (16%)

Query: 88  SHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAK 147
           ++++ Y  + ++ +     +    +   P + GSGIPE+KT+L+G I+  YL       K
Sbjct: 205 AYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIK 264

Query: 148 VVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYLGRVRTTTIGE-PENKSKQNEMLVAAAA 206
            + L   LA  S L LGK GP VH    +A   G +      +  +N++K+ E+L AAAA
Sbjct: 265 TITL--VLAVSSGLSLGKEGPLVH----VACCCGNILCHCFNKYRKNEAKRREVLSAAAA 318

Query: 207 VGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETITSL 266
            GV+  F AP  GVLFS+E +S +F ++  WR FFAA   AF  R +  F + +     L
Sbjct: 319 AGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSR---LVL 375

Query: 267 YKTSFRVDVPFDLPEIFFFVAL---GGICGVLSCAYLFCQRTFLSFIKTN-RYSSKLLAT 322
           +   F    P+ L E+  F+ L   GG+ G L             FI+TN  +  K   T
Sbjct: 376 FYVEFH--TPWHLFELVPFILLGIFGGLWGAL-------------FIRTNIAWCRKRKTT 420

Query: 323 SKPVYSALATLLLASIT----YPPGVGHFLASRLSMKQHLDSLFDN-------------H 365
               Y  +  L++ +IT    +P        +R+S  + +  LF++             +
Sbjct: 421 QLGKYPVIEVLVVTAITAILAFPNEY-----TRMSTSELISELFNDCGLLDSSKLCDYEN 475

Query: 366 SWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGY 425
            +        P  P  +      W+           LA  L++K  + I    + +P+G 
Sbjct: 476 RFNTSKGGELPDRPAGVGVYSAMWQ-----------LALTLILKIVITIFTFGMKIPSGL 524

Query: 426 FMPIFILGAAIGRLLG---EALAVAFPEGIVTGGVTNP----IMPGGYALAGAAAFSGAV 478
           F+P   +GA  GRLLG   E LA    E  V     +     I PG YA+ GAAA  G V
Sbjct: 525 FIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGV 584

Query: 479 TH-TISTALLAFELTGQIVHALPVLMAVLAANAIAQSC-QPSFYDGTIIVKKLPYLPRIL 536
           T  T+S  ++ FELTG + + +P++ A + +  +A +  +   YD  I +   P+L    
Sbjct: 585 TRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLE--- 641

Query: 537 GRNIGSHHVRVEHFM-----NHSITTLAKDT-PLEEVVKVVTSTDVTEYPLVESTESQIL 590
            +   +H       M     +  +T L +D+  +E+V  +++ T  + +P+V S ESQ L
Sbjct: 642 AKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRL 701

Query: 591 VGIVQRAQLVQALQ--------------------AEP-PSRAPGHQCLQDILARGCPTEP 629
           VG V R  L+ +++                    + P P   P    L++IL       P
Sbjct: 702 VGFVLRRDLIISIENARKKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNIL----DLSP 757

Query: 630 VTLTLFSETTLHQAQNLFKLLNLQSLFVTSRGRAVGCVSWVEMKKAISNLTN 681
            T+T    T +    ++F+ L L+   VT  GR +G ++  ++ K I+ + N
Sbjct: 758 FTVT--DLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHIAQMAN 807


>gi|189217921 chloride channel 5 isoform a [Homo sapiens]
          Length = 816

 Score =  186 bits (473), Expect = 5e-47
 Identities = 179/652 (27%), Positives = 293/652 (44%), Gaps = 107/652 (16%)

Query: 88  SHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAK 147
           ++++ Y  + ++ +     +    +   P + GSGIPE+KT+L+G I+  YL       K
Sbjct: 205 AYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIK 264

Query: 148 VVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYLGRVRTTTIGE-PENKSKQNEMLVAAAA 206
            + L   LA  S L LGK GP VH    +A   G +      +  +N++K+ E+L AAAA
Sbjct: 265 TITL--VLAVSSGLSLGKEGPLVH----VACCCGNILCHCFNKYRKNEAKRREVLSAAAA 318

Query: 207 VGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETITSL 266
            GV+  F AP  GVLFS+E +S +F ++  WR FFAA   AF  R +  F + +     L
Sbjct: 319 AGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSR---LVL 375

Query: 267 YKTSFRVDVPFDLPEIFFFVAL---GGICGVLSCAYLFCQRTFLSFIKTN-RYSSKLLAT 322
           +   F    P+ L E+  F+ L   GG+ G L             FI+TN  +  K   T
Sbjct: 376 FYVEFH--TPWHLFELVPFILLGIFGGLWGAL-------------FIRTNIAWCRKRKTT 420

Query: 323 SKPVYSALATLLLASIT----YPPGVGHFLASRLSMKQHLDSLFDN-------------H 365
               Y  +  L++ +IT    +P        +R+S  + +  LF++             +
Sbjct: 421 QLGKYPVIEVLVVTAITAILAFPNEY-----TRMSTSELISELFNDCGLLDSSKLCDYEN 475

Query: 366 SWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGY 425
            +        P  P  +      W+           LA  L++K  + I    + +P+G 
Sbjct: 476 RFNTSKGGELPDRPAGVGVYSAMWQ-----------LALTLILKIVITIFTFGMKIPSGL 524

Query: 426 FMPIFILGAAIGRLLG---EALAVAFPEGIVTGGVTNP----IMPGGYALAGAAAFSGAV 478
           F+P   +GA  GRLLG   E LA    E  V     +     I PG YA+ GAAA  G V
Sbjct: 525 FIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGV 584

Query: 479 TH-TISTALLAFELTGQIVHALPVLMAVLAANAIAQSC-QPSFYDGTIIVKKLPYLPRIL 536
           T  T+S  ++ FELTG + + +P++ A + +  +A +  +   YD  I +   P+L    
Sbjct: 585 TRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLE--- 641

Query: 537 GRNIGSHHVRVEHFM-----NHSITTLAKDT-PLEEVVKVVTSTDVTEYPLVESTESQIL 590
            +   +H       M     +  +T L +D+  +E+V  +++ T  + +P+V S ESQ L
Sbjct: 642 AKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRL 701

Query: 591 VGIVQRAQLVQALQ--------------------AEP-PSRAPGHQCLQDILARGCPTEP 629
           VG V R  L+ +++                    + P P   P    L++IL       P
Sbjct: 702 VGFVLRRDLIISIENARKKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNIL----DLSP 757

Query: 630 VTLTLFSETTLHQAQNLFKLLNLQSLFVTSRGRAVGCVSWVEMKKAISNLTN 681
            T+T    T +    ++F+ L L+   VT  GR +G ++  ++ K I+ + N
Sbjct: 758 FTVT--DLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHIAQMAN 807


>gi|4557473 chloride channel 5 isoform b [Homo sapiens]
          Length = 746

 Score =  186 bits (473), Expect = 5e-47
 Identities = 179/652 (27%), Positives = 293/652 (44%), Gaps = 107/652 (16%)

Query: 88  SHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAK 147
           ++++ Y  + ++ +     +    +   P + GSGIPE+KT+L+G I+  YL       K
Sbjct: 135 AYIVNYFMYVLWALLFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLVIK 194

Query: 148 VVGLSCTLATGSTLFLGKVGPFVHLSVMIAAYLGRVRTTTIGE-PENKSKQNEMLVAAAA 206
            + L   LA  S L LGK GP VH    +A   G +      +  +N++K+ E+L AAAA
Sbjct: 195 TITL--VLAVSSGLSLGKEGPLVH----VACCCGNILCHCFNKYRKNEAKRREVLSAAAA 248

Query: 207 VGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETITSL 266
            GV+  F AP  GVLFS+E +S +F ++  WR FFAA   AF  R +  F + +     L
Sbjct: 249 AGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFTLRSINPFGNSR---LVL 305

Query: 267 YKTSFRVDVPFDLPEIFFFVAL---GGICGVLSCAYLFCQRTFLSFIKTN-RYSSKLLAT 322
           +   F    P+ L E+  F+ L   GG+ G L             FI+TN  +  K   T
Sbjct: 306 FYVEFH--TPWHLFELVPFILLGIFGGLWGAL-------------FIRTNIAWCRKRKTT 350

Query: 323 SKPVYSALATLLLASIT----YPPGVGHFLASRLSMKQHLDSLFDN-------------H 365
               Y  +  L++ +IT    +P        +R+S  + +  LF++             +
Sbjct: 351 QLGKYPVIEVLVVTAITAILAFPNEY-----TRMSTSELISELFNDCGLLDSSKLCDYEN 405

Query: 366 SWALMTQNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGY 425
            +        P  P  +      W+           LA  L++K  + I    + +P+G 
Sbjct: 406 RFNTSKGGELPDRPAGVGVYSAMWQ-----------LALTLILKIVITIFTFGMKIPSGL 454

Query: 426 FMPIFILGAAIGRLLG---EALAVAFPEGIVTGGVTNP----IMPGGYALAGAAAFSGAV 478
           F+P   +GA  GRLLG   E LA    E  V     +     I PG YA+ GAAA  G V
Sbjct: 455 FIPSMAVGAIAGRLLGVGMEQLAYYHQEWTVFNSWCSQGADCITPGLYAMVGAAACLGGV 514

Query: 479 TH-TISTALLAFELTGQIVHALPVLMAVLAANAIAQSC-QPSFYDGTIIVKKLPYLPRIL 536
           T  T+S  ++ FELTG + + +P++ A + +  +A +  +   YD  I +   P+L    
Sbjct: 515 TRMTVSLVVIMFELTGGLEYIVPLMAAAMTSKWVADALGREGIYDAHIRLNGYPFLE--- 571

Query: 537 GRNIGSHHVRVEHFM-----NHSITTLAKDT-PLEEVVKVVTSTDVTEYPLVESTESQIL 590
            +   +H       M     +  +T L +D+  +E+V  +++ T  + +P+V S ESQ L
Sbjct: 572 AKEEFAHKTLAMDVMKPRRNDPLLTVLTQDSMTVEDVETIISETTYSGFPVVVSRESQRL 631

Query: 591 VGIVQRAQLVQALQ--------------------AEP-PSRAPGHQCLQDILARGCPTEP 629
           VG V R  L+ +++                    + P P   P    L++IL       P
Sbjct: 632 VGFVLRRDLIISIENARKKQDGVVSTSIIYFTEHSPPLPPYTPPTLKLRNIL----DLSP 687

Query: 630 VTLTLFSETTLHQAQNLFKLLNLQSLFVTSRGRAVGCVSWVEMKKAISNLTN 681
            T+T    T +    ++F+ L L+   VT  GR +G ++  ++ K I+ + N
Sbjct: 688 FTVT--DLTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDVLKHIAQMAN 737


>gi|55770838 chloride channel 3 isoform b [Homo sapiens]
          Length = 818

 Score =  179 bits (455), Expect = 6e-45
 Identities = 168/648 (25%), Positives = 283/648 (43%), Gaps = 98/648 (15%)

Query: 88  SHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAK 147
           S+++ Y+ +  + ++    +    +   P + GSGIPE+KT+L+G I+  YL       K
Sbjct: 206 SYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIK 265

Query: 148 VVGLSCTLATGSTLFLGKVGPFVHLSVM---IAAYLGRVRTTTIGEPENKSKQNEMLVAA 204
            + L   LA  S L LGK GP VH++     I +YL    +T      N++K+ E+L AA
Sbjct: 266 TITL--VLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYST------NEAKKREVLSAA 317

Query: 205 AAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETIT 264
           +A GV+  F AP  GVLFS+E +S +F ++  WR FFAA   AF+ R +  F + +    
Sbjct: 318 SAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSR---- 373

Query: 265 SLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSK 324
            L         P+ L E+F F+ LG   G+    ++     +    K+ ++         
Sbjct: 374 -LVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGK------- 425

Query: 325 PVYSALATLLLASIT----YPPGVGHFLASRLSMKQHLD-------SLFD--NHSWALMT 371
             Y  L  +++A+IT    +P        S L  +   D       SL D  N   A   
Sbjct: 426 --YPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKI 483

Query: 372 QNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFI 431
            +  P  P  +      W+           L   L+ K  M +    I +P+G F+P   
Sbjct: 484 VDDIPDRPAGIGVYSAIWQ-----------LCLALIFKIIMTVFTFGIKVPSGLFIPSMA 532

Query: 432 LGAAIGRLLGEALA---------VAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTH-T 481
           +GA  GR++G A+            F E    G   + I PG YA+ GAAA  G VT  T
Sbjct: 533 IGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVG--ADCITPGLYAMVGAAACLGGVTRMT 590

Query: 482 ISTALLAFELTGQIVHALPVLMAVLAANAIAQSC-QPSFYDGTIIVKKLPYLPRILGRNI 540
           +S  ++ FELTG + + +P++ AV+ +  +  +  +   Y+  I +   P+L     +  
Sbjct: 591 VSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLD---AKEE 647

Query: 541 GSHHVRVEHFM-----NHSITTLAKDT-PLEEVVKVVTSTDVTEYPLVESTESQILVGIV 594
            +H       M     +  +  L +D   ++++  ++  T    +P++ S ESQ LVG  
Sbjct: 648 FTHTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFA 707

Query: 595 QRAQLVQALQA---------------------EPPSRAPGHQCLQDILARGCPTEPVTLT 633
            R  L  A+++                       P+ +P    L+ IL       P T+T
Sbjct: 708 LRRDLTIAIESARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSIL----DMSPFTVT 763

Query: 634 LFSETTLHQAQNLFKLLNLQSLFVTSRGRAVGCVSWVEMKKAISNLTN 681
               T +    ++F+ L L+   VT  GR +G ++  ++ + ++   N
Sbjct: 764 --DHTPMEIVVDIFRKLGLRQCLVTHNGRLLGIITKKDILRHMAQTAN 809


>gi|55770840 chloride channel 3 isoform e [Homo sapiens]
          Length = 866

 Score =  176 bits (445), Expect = 8e-44
 Identities = 166/635 (26%), Positives = 276/635 (43%), Gaps = 98/635 (15%)

Query: 88  SHLLRYLSWTVYPVALVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAK 147
           S+++ Y+ +  + ++    +    +   P + GSGIPE+KT+L+G I+  YL       K
Sbjct: 206 SYIMNYIMYIFWALSFAFLAVSLVKVFAPYACGSGIPEIKTILSGFIIRGYLGKWTLMIK 265

Query: 148 VVGLSCTLATGSTLFLGKVGPFVHLSVM---IAAYLGRVRTTTIGEPENKSKQNEMLVAA 204
            + L   LA  S L LGK GP VH++     I +YL    +T      N++K+ E+L AA
Sbjct: 266 TITL--VLAVASGLSLGKEGPLVHVACCCGNIFSYLFPKYST------NEAKKREVLSAA 317

Query: 205 AAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFRLLAVFNSEQETIT 264
           +A GV+  F AP  GVLFS+E +S +F ++  WR FFAA   AF+ R +  F + +    
Sbjct: 318 SAAGVSVAFGAPIGGVLFSLEEVSYYFPLKTLWRSFFAALVAAFVLRSINPFGNSR---- 373

Query: 265 SLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSK 324
            L         P+ L E+F F+ LG   G+    ++     +    K+ ++         
Sbjct: 374 -LVLFYVEYHTPWYLFELFPFILLGVFGGLWGAFFIRANIAWCRRRKSTKFGK------- 425

Query: 325 PVYSALATLLLASIT----YPPGVGHFLASRLSMKQHLD-------SLFD--NHSWALMT 371
             Y  L  +++A+IT    +P        S L  +   D       SL D  N   A   
Sbjct: 426 --YPVLEVIIVAAITAVIAFPNPYTRLNTSELIKELFTDCGPLESSSLCDYRNDMNASKI 483

Query: 372 QNSSPPWPEELDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFI 431
            +  P  P  +      W+           L   L+ K  M +    I +P+G F+P   
Sbjct: 484 VDDIPDRPAGIGVYSAIWQ-----------LCLALIFKIIMTVFTFGIKVPSGLFIPSMA 532

Query: 432 LGAAIGRLLGEALA---------VAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTH-T 481
           +GA  GR++G A+            F E    G   + I PG YA+ GAAA  G VT  T
Sbjct: 533 IGAIAGRIVGIAVEQLAYYHHDWFIFKEWCEVG--ADCITPGLYAMVGAAACLGGVTRMT 590

Query: 482 ISTALLAFELTGQIVHALPVLMAVLAANAIAQSC-QPSFYDGTIIVKKLPYLPRILGRNI 540
           +S  ++ FELTG + + +P++ AV+ +  +  +  +   Y+  I +   P+L     +  
Sbjct: 591 VSLVVIVFELTGGLEYIVPLMAAVMTSKWVGDAFGREGIYEAHIRLNGYPFLD---AKEE 647

Query: 541 GSHHVRVEHFM-----NHSITTLAKDT-PLEEVVKVVTSTDVTEYPLVESTESQILVGIV 594
            +H       M     +  +  L +D   ++++  ++  T    +P++ S ESQ LVG  
Sbjct: 648 FTHTTLAADVMRPRRNDPPLAVLTQDNMTVDDIENMINETSYNGFPVIMSKESQRLVGFA 707

Query: 595 QRAQLVQALQA---------------------EPPSRAPGHQCLQDILARGCPTEPVTLT 633
            R  L  A+++                       P+ +P    L+ IL       P T+T
Sbjct: 708 LRRDLTIAIESARKKQEGIVGSSRVCFAQHTPSLPAESPRPLKLRSIL----DMSPFTVT 763

Query: 634 LFSETTLHQAQNLFKLLNLQSLFVTSRGRAVGCVS 668
               T +    ++F+ L L+   VT  G  +G ++
Sbjct: 764 --DHTPMEIVVDIFRKLGLRQCLVTHNGIVLGIIT 796


>gi|167466160 chloride channel 7 isoform b [Homo sapiens]
          Length = 781

 Score =  146 bits (369), Expect = 5e-35
 Identities = 148/589 (25%), Positives = 260/589 (44%), Gaps = 60/589 (10%)

Query: 50  WYFLMTLGVLMALVSYAMNFAIGC-------VVRAHQWLYREIGDSHLLRYLSWTVYPVA 102
           W     +G+L  LV+  ++  +         V++ +   + E G       L W     A
Sbjct: 103 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSF-SLLLWATLNAA 161

Query: 103 LVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLF 162
            V   S     I P + GSGIP++K  L GV +   + +K    KV G+  ++  G  L 
Sbjct: 162 FVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGG--LA 219

Query: 163 LGKVGPFVHLSVMIAAYLGRVRTTTIGEP-------ENKSKQNEMLVAAAAVGVATVFAA 215
           +GK GP +H   +IAA + + R+T++             +++ + + A AA GV+  F A
Sbjct: 220 VGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGA 279

Query: 216 PFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFR-LLAVFNSEQETITSLYKTSF-RV 273
           P  GVLFS+E  +S ++    WR FFA+    F    +L++++     ++S    +F R 
Sbjct: 280 PVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRF 339

Query: 274 D---VPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYSAL 330
           D   + + + EI  F+A+G + GVL   +         F        ++    +P    +
Sbjct: 340 DSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMF--------RIRYIHRPCLQVI 391

Query: 331 ATLLLASITYPPGVGHFLASR-------LSMKQHLDSLF--DNHSWALMTQNSSPPWPEE 381
             +L+A++T         +SR        SM   L  LF  D    ++     + P    
Sbjct: 392 EAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPL-QLFCADGEYNSMAAAFFNTPEKSV 450

Query: 382 LDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFILGAAIGRLLG 441
           +   H     Y+P      TL  F ++ F++      + + AG F+P  ++GAA GRL G
Sbjct: 451 VSLFHDPPGSYNPL-----TLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFG 505

Query: 442 EALAVAFPEGIVTGGVTNPIMPGGYALAGAAA-FSGAVTHTISTALLAFELTGQIVHALP 500
            +L+      I          PG YAL GAAA   G V  T+S  ++  E T  + +  P
Sbjct: 506 ISLSYLTGAAIWAD-------PGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFP 558

Query: 501 VLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNIGSHHVRVEHFMNHSITTLAK 560
           +++ ++ A  +        YD  I ++ +P+L       + SH +     M+  +T L +
Sbjct: 559 IMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLH--WEAPVTSHSLTAREVMSTPVTCLRR 616

Query: 561 DTPLEEVVKVV--TSTDVTEYPLVE---STESQILVGIVQRAQLVQALQ 604
              +  +V V+  T+++   +P+VE    T+   L G++ R+QL+  L+
Sbjct: 617 REKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLK 665


>gi|14149607 chloride channel 7 isoform a [Homo sapiens]
          Length = 805

 Score =  146 bits (369), Expect = 5e-35
 Identities = 148/589 (25%), Positives = 260/589 (44%), Gaps = 60/589 (10%)

Query: 50  WYFLMTLGVLMALVSYAMNFAIGC-------VVRAHQWLYREIGDSHLLRYLSWTVYPVA 102
           W     +G+L  LV+  ++  +         V++ +   + E G       L W     A
Sbjct: 127 WVICALIGILTGLVACFIDIVVENLAGLKYRVIKGNIDKFTEKGGLSF-SLLLWATLNAA 185

Query: 103 LVSFSSGFSQSITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLF 162
            V   S     I P + GSGIP++K  L GV +   + +K    KV G+  ++  G  L 
Sbjct: 186 FVLVGSVIVAFIEPVAAGSGIPQIKCFLNGVKIPHVVRLKTLVIKVSGVILSVVGG--LA 243

Query: 163 LGKVGPFVHLSVMIAAYLGRVRTTTIGEP-------ENKSKQNEMLVAAAAVGVATVFAA 215
           +GK GP +H   +IAA + + R+T++             +++ + + A AA GV+  F A
Sbjct: 244 VGKEGPMIHSGSVIAAGISQGRSTSLKRDFKIFEYFRRDTEKRDFVSAGAAAGVSAAFGA 303

Query: 216 PFSGVLFSIEVMSSHFSVRDYWRGFFAATCGAFIFR-LLAVFNSEQETITSLYKTSF-RV 273
           P  GVLFS+E  +S ++    WR FFA+    F    +L++++     ++S    +F R 
Sbjct: 304 PVGGVLFSLEEGASFWNQFLTWRIFFASMISTFTLNFVLSIYHGNMWDLSSPGLINFGRF 363

Query: 274 D---VPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYSAL 330
           D   + + + EI  F+A+G + GVL   +         F        ++    +P    +
Sbjct: 364 DSEKMAYTIHEIPVFIAMGVVGGVLGAVFNALNYWLTMF--------RIRYIHRPCLQVI 415

Query: 331 ATLLLASITYPPGVGHFLASR-------LSMKQHLDSLF--DNHSWALMTQNSSPPWPEE 381
             +L+A++T         +SR        SM   L  LF  D    ++     + P    
Sbjct: 416 EAVLVAAVTATVAFVLIYSSRDCQPLQGGSMSYPL-QLFCADGEYNSMAAAFFNTPEKSV 474

Query: 382 LDPQHLWWEWYHPRFTIFGTLAFFLVMKFWMLILATTIPMPAGYFMPIFILGAAIGRLLG 441
           +   H     Y+P      TL  F ++ F++      + + AG F+P  ++GAA GRL G
Sbjct: 475 VSLFHDPPGSYNPL-----TLGLFTLVYFFLACWTYGLTVSAGVFIPSLLIGAAWGRLFG 529

Query: 442 EALAVAFPEGIVTGGVTNPIMPGGYALAGAAA-FSGAVTHTISTALLAFELTGQIVHALP 500
            +L+      I          PG YAL GAAA   G V  T+S  ++  E T  + +  P
Sbjct: 530 ISLSYLTGAAIWAD-------PGKYALMGAAAQLGGIVRMTLSLTVIMMEATSNVTYGFP 582

Query: 501 VLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNIGSHHVRVEHFMNHSITTLAK 560
           +++ ++ A  +        YD  I ++ +P+L       + SH +     M+  +T L +
Sbjct: 583 IMLVLMTAKIVGDVFIEGLYDMHIQLQSVPFLH--WEAPVTSHSLTAREVMSTPVTCLRR 640

Query: 561 DTPLEEVVKVV--TSTDVTEYPLVE---STESQILVGIVQRAQLVQALQ 604
              +  +V V+  T+++   +P+VE    T+   L G++ R+QL+  L+
Sbjct: 641 REKVGVIVDVLSDTASNHNGFPVVEHADDTQPARLQGLILRSQLIVLLK 689


>gi|4502873 chloride channel 6 isoform ClC-6a [Homo sapiens]
          Length = 869

 Score =  119 bits (299), Expect = 7e-27
 Identities = 125/516 (24%), Positives = 220/516 (42%), Gaps = 76/516 (14%)

Query: 114 ITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLS 173
           I P + GSGIPE+K  L GV +   + ++    KV+G+  ++A G  LF+GK GP +H  
Sbjct: 150 IEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGG--LFVGKEGPMIHSG 207

Query: 174 VMIAAYLGRVRTTTIGEPE-------NKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEV 226
            ++ A L + ++ ++ + +       +   + + + A AA GVA  F AP  G LFS+E 
Sbjct: 208 SVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEE 267

Query: 227 MSSHFSVRDYWRGFFAATCGAFI---------------FRLLAVFNSEQETITSLYKTSF 271
            SS ++    W+  F +    F                F+L  + N  +   +   K   
Sbjct: 268 GSSFWNQGLTWKVLFCSMSATFTLNFFRSGIQFGSWGSFQLPGLLNFGEFKCSDSDKKCH 327

Query: 272 RVDVPFDLPEIFFFVALGGICGVLSCAYLFCQRTFLSFIKTNRYSSKLLATSKPVYSALA 331
                +   ++ FFV +G I G+L   +    +      +  +Y  + +     +   L 
Sbjct: 328 L----WTAMDLGFFVVMGVIGGLLGATFNCLNK------RLAKYRMRNVHPKPKLVRVLE 377

Query: 332 TLLLASITYPPGVGHFLASRL---SMKQHLDSLFDNHSWAL-MTQNSSPPWPEELDPQHL 387
           +LL++ +T    V  F+AS +     +    S   N S+ L +T++ +        P   
Sbjct: 378 SLLVSLVT---TVVVFVASMVLGECRQMSSSSQIGNDSFQLQVTEDVNSSIKTFFCPN-- 432

Query: 388 WWEWYHPRFTIF--------------------GTLAFFLVMKFWMLILATTIPMPAGYFM 427
             + Y+   T+F                     TLA F V+ F +      I +P+G F+
Sbjct: 433 --DTYNDMATLFFNPQESAILQLFHQDGTFSPVTLALFFVLYFLLACWTYGISVPSGLFV 490

Query: 428 PIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPGGYALAGAAAFSGAVTH-TISTAL 486
           P  + GAA GRL+   L      G         I  G +AL GAAAF G V   TIS  +
Sbjct: 491 PSLLCGAAFGRLVANVLKSYIGLG--------HIYSGTFALIGAAAFLGGVVRMTISLTV 542

Query: 487 LAFELTGQIVHALPVLMAVLAANAIAQSCQPSFYDGTIIVKKLPYLPRILGRNIGSHHVR 546
           +  E T +I + LP+++ ++ A           YD  + ++ +P L       +    +R
Sbjct: 543 ILIESTNEITYGLPIMVTLMVAKWTGDFFNKGIYDIHVGLRGVPLLE--WETEVEMDKLR 600

Query: 547 VEHFMNHSITTLAKDTPLEEVVKVVTSTDVTEYPLV 582
               M  ++T +   T ++ +V ++ +T    +P+V
Sbjct: 601 ASDIMEPNLTYVYPHTRIQSLVSILRTTVHHAFPVV 636


>gi|12025671 chloride channel 6 isoform ClC-6c [Homo sapiens]
          Length = 353

 Score = 72.8 bits (177), Expect = 1e-12
 Identities = 45/142 (31%), Positives = 75/142 (52%), Gaps = 9/142 (6%)

Query: 114 ITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLS 173
           I P + GSGIPE+K  L GV +   + ++    KV+G+  ++A G  LF+GK GP +H  
Sbjct: 150 IEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGG--LFVGKEGPMIHSG 207

Query: 174 VMIAAYLGRVRTTTIGEPE-------NKSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEV 226
            ++ A L + ++ ++ + +       +   + + + A AA GVA  F AP  G LFS+E 
Sbjct: 208 SVVGAGLPQFQSISLRKIQFNFPYFRSDRDKRDFVSAGAAAGVAAAFGAPIGGTLFSLEE 267

Query: 227 MSSHFSVRDYWRGFFAATCGAF 248
            SS ++    W+  F +    F
Sbjct: 268 GSSFWNQGLTWKVLFCSMSATF 289


>gi|12025673 chloride channel 6 isoform ClC-6d [Homo sapiens]
          Length = 308

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 26/75 (34%), Positives = 45/75 (60%), Gaps = 2/75 (2%)

Query: 114 ITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLS 173
           I P + GSGIPE+K  L GV +   + ++    KV+G+  ++A G  LF+GK GP +H  
Sbjct: 150 IEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGG--LFVGKEGPMIHSG 207

Query: 174 VMIAAYLGRVRTTTI 188
            ++ A L + ++ ++
Sbjct: 208 SVVGAGLPQFQSISL 222


>gi|12025668 chloride channel 6 isoform ClC-6b [Homo sapiens]
          Length = 320

 Score = 47.8 bits (112), Expect = 3e-05
 Identities = 26/75 (34%), Positives = 45/75 (60%), Gaps = 2/75 (2%)

Query: 114 ITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGSTLFLGKVGPFVHLS 173
           I P + GSGIPE+K  L GV +   + ++    KV+G+  ++A G  LF+GK GP +H  
Sbjct: 150 IEPVAAGSGIPEVKCYLNGVKVPGIVRLRTLLCKVLGVLFSVAGG--LFVGKEGPMIHSG 207

Query: 174 VMIAAYLGRVRTTTI 188
            ++ A L + ++ ++
Sbjct: 208 SVVGAGLPQFQSISL 222


>gi|61676188 HECT, UBA and WWE domain containing 1 [Homo sapiens]
          Length = 4374

 Score = 31.2 bits (69), Expect = 3.3
 Identities = 18/48 (37%), Positives = 27/48 (56%)

Query: 113  SITPSSGGSGIPELKTMLAGVILEDYLDIKNFGAKVVGLSCTLATGST 160
            ++T SSG +G   L T+L   I+ED   +++   KVV  + T   GST
Sbjct: 1806 NLTQSSGFNGFTPLVTLLLRHIIEDPCTLRHTMEKVVRSAATSGAGST 1853


>gi|126352608 elastin isoform e precursor [Homo sapiens]
          Length = 705

 Score = 30.8 bits (68), Expect = 4.4
 Identities = 20/52 (38%), Positives = 25/52 (48%), Gaps = 6/52 (11%)

Query: 420 PMPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPGGYALAGA 471
           P+P G      + GA +G  LG   AV FP  +V GGV +       A AGA
Sbjct: 65  PVPGG------LAGAGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGA 110


>gi|126352446 elastin isoform d precursor [Homo sapiens]
          Length = 711

 Score = 30.8 bits (68), Expect = 4.4
 Identities = 20/52 (38%), Positives = 25/52 (48%), Gaps = 6/52 (11%)

Query: 420 PMPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPGGYALAGA 471
           P+P G      + GA +G  LG   AV FP  +V GGV +       A AGA
Sbjct: 65  PVPGG------LAGAGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGA 110


>gi|126352322 elastin isoform c precursor [Homo sapiens]
          Length = 692

 Score = 30.8 bits (68), Expect = 4.4
 Identities = 20/52 (38%), Positives = 25/52 (48%), Gaps = 6/52 (11%)

Query: 420 PMPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPGGYALAGA 471
           P+P G      + GA +G  LG   AV FP  +V GGV +       A AGA
Sbjct: 65  PVPGG------LAGAGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGA 110


>gi|126352700 elastin isoform b precursor [Homo sapiens]
          Length = 677

 Score = 30.8 bits (68), Expect = 4.4
 Identities = 20/52 (38%), Positives = 25/52 (48%), Gaps = 6/52 (11%)

Query: 420 PMPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPGGYALAGA 471
           P+P G      + GA +G  LG   AV FP  +V GGV +       A AGA
Sbjct: 55  PVPGG------LAGAGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGA 100


>gi|126352440 elastin isoform a precursor [Homo sapiens]
          Length = 724

 Score = 30.8 bits (68), Expect = 4.4
 Identities = 20/52 (38%), Positives = 25/52 (48%), Gaps = 6/52 (11%)

Query: 420 PMPAGYFMPIFILGAAIGRLLGEALAVAFPEGIVTGGVTNPIMPGGYALAGA 471
           P+P G      + GA +G  LG   AV FP  +V GGV +       A AGA
Sbjct: 65  PVPGG------LAGAGLGAGLGAFPAVTFPGALVPGGVADAAAAYKAAKAGA 110


>gi|156938237 ADP-ribosylation factor-like 17 isoform a [Homo
           sapiens]
          Length = 177

 Score = 30.8 bits (68), Expect = 4.4
 Identities = 18/54 (33%), Positives = 25/54 (46%), Gaps = 1/54 (1%)

Query: 194 KSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGA 247
           K K  E + A   VG   V    +    F++  + SHF +R  W+ FF  T GA
Sbjct: 36  KLKLGETVPAVPTVGFC-VETVEYKNNTFAVWDVGSHFKIRPLWQHFFQNTKGA 88


>gi|166063999 hypothetical protein LOC51326 isoform a [Homo sapiens]
          Length = 177

 Score = 30.8 bits (68), Expect = 4.4
 Identities = 18/54 (33%), Positives = 25/54 (46%), Gaps = 1/54 (1%)

Query: 194 KSKQNEMLVAAAAVGVATVFAAPFSGVLFSIEVMSSHFSVRDYWRGFFAATCGA 247
           K K  E + A   VG   V    +    F++  + SHF +R  W+ FF  T GA
Sbjct: 36  KLKLGETVPAVPTVGFC-VETVEYKNNTFAVWDVGSHFKIRPLWQHFFQNTKGA 88


>gi|48255947 plasma membrane calcium ATPase 1 isoform 1a [Homo
           sapiens]
          Length = 1176

 Score = 29.6 bits (65), Expect = 9.7
 Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 10/59 (16%)

Query: 397 TIFGTLAFFLVMKFWMLI---LATTIPMPAGYFMPIFILGAAIGRLLGEALAVAFPEGI 452
           T+   + +F++  FW+     LA   P+   YF+  FI+G  +       L VA PEG+
Sbjct: 384 TVIILVLYFVIDTFWVQKRPWLAECTPIYIQYFVKFFIIGVTV-------LVVAVPEGL 435


>gi|48255945 plasma membrane calcium ATPase 1 isoform 1b [Homo
           sapiens]
          Length = 1220

 Score = 29.6 bits (65), Expect = 9.7
 Identities = 18/59 (30%), Positives = 29/59 (49%), Gaps = 10/59 (16%)

Query: 397 TIFGTLAFFLVMKFWMLI---LATTIPMPAGYFMPIFILGAAIGRLLGEALAVAFPEGI 452
           T+   + +F++  FW+     LA   P+   YF+  FI+G  +       L VA PEG+
Sbjct: 384 TVIILVLYFVIDTFWVQKRPWLAECTPIYIQYFVKFFIIGVTV-------LVVAVPEGL 435


>gi|84508631 phosphatidylglycerophosphate synthase 1 [Homo sapiens]
          Length = 556

 Score = 29.6 bits (65), Expect = 9.7
 Identities = 16/63 (25%), Positives = 26/63 (41%)

Query: 246 GAFIFRLLAVFNSEQETITSLYKTSFRVDVPFDLPEIFFFVALGGICGVLSCAYLFCQRT 305
           GA ++     FN  Q  +  +  T     +    PE+  F    G+ G +  AY+  +R 
Sbjct: 379 GAKVYLTTGYFNLTQAYMDLVLGTRAEYQILLASPEVNGFFGAKGVAGAIPAAYVHIERQ 438

Query: 306 FLS 308
           F S
Sbjct: 439 FFS 441


>gi|41349446 stromal interaction molecule 2 [Homo sapiens]
          Length = 833

 Score = 29.6 bits (65), Expect = 9.7
 Identities = 12/35 (34%), Positives = 19/35 (54%)

Query: 345 GHFLASRLSMKQHLDSLFDNHSWALMTQNSSPPWP 379
           G  +A    +     SL+ +HSW +M + S PP+P
Sbjct: 529 GFQIAHNSGLPSLTSSLYSDHSWVVMPRVSIPPYP 563


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.324    0.138    0.424 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 25,160,198
Number of Sequences: 37866
Number of extensions: 1050010
Number of successful extensions: 3400
Number of sequences better than 10.0: 29
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 4
Number of HSP's that attempted gapping in prelim test: 3300
Number of HSP's gapped (non-prelim): 44
length of query: 686
length of database: 18,247,518
effective HSP length: 109
effective length of query: 577
effective length of database: 14,120,124
effective search space: 8147311548
effective search space used: 8147311548
T: 11
A: 40
X1: 15 ( 7.0 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 40 (21.6 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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