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Search of human proteins with 112380630
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|112380630 leiomodin 1 (smooth muscle) [Homo sapiens]
(600 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|112380630 leiomodin 1 (smooth muscle) [Homo sapiens] 1184 0.0
gi|150378503 leiomodin 2 (cardiac) [Homo sapiens] 295 8e-80
gi|54607116 leiomodin 3 (fetal) [Homo sapiens] 277 2e-74
gi|7657647 neuronal tropomodulin isoform a [Homo sapiens] 163 4e-40
gi|4507553 tropomodulin 1 [Homo sapiens] 156 6e-38
gi|7657649 tropomodulin 3 (ubiquitous) [Homo sapiens] 155 1e-37
gi|156415984 tropomodulin 4 (muscle) [Homo sapiens] 136 5e-32
gi|218931148 neuronal tropomodulin isoform b [Homo sapiens] 120 4e-27
gi|239749449 PREDICTED: hypothetical protein [Homo sapiens] 83 6e-16
gi|239754909 PREDICTED: hypothetical protein [Homo sapiens] 76 8e-14
gi|4557509 cylicin 2 [Homo sapiens] 75 2e-13
gi|55741709 RNA binding motif protein 25 [Homo sapiens] 72 1e-12
gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1... 70 4e-12
gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo ... 70 6e-12
gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens] 70 6e-12
gi|239757964 PREDICTED: hypothetical protein [Homo sapiens] 69 9e-12
gi|116089325 splicing factor, arginine/serine-rich 12 isoform a ... 66 1e-10
gi|21040255 splicing factor, arginine/serine-rich 12 isoform b [... 66 1e-10
gi|13540523 nucleosomal binding protein 1 [Homo sapiens] 65 2e-10
gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo sapi... 64 3e-10
gi|84043963 eukaryotic translation initiation factor 5B [Homo sa... 64 4e-10
gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Hom... 62 2e-09
gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens] 62 2e-09
gi|44680105 caldesmon 1 isoform 1 [Homo sapiens] 62 2e-09
gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens] 60 4e-09
gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens] 59 1e-08
gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens] 59 1e-08
gi|42560244 peptidylprolyl isomerase G [Homo sapiens] 59 1e-08
gi|126723060 zinc finger CCCH-type containing 4 [Homo sapiens] 59 1e-08
gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain ... 59 2e-08
>gi|112380630 leiomodin 1 (smooth muscle) [Homo sapiens]
Length = 600
Score = 1184 bits (3064), Expect = 0.0
Identities = 600/600 (100%), Positives = 600/600 (100%)
Query: 1 MSRVAKYRRQVSEDPDIDSLLETLSPEEMEELEKELDVVDPDGSVPVGLRQRNQTEKQST 60
MSRVAKYRRQVSEDPDIDSLLETLSPEEMEELEKELDVVDPDGSVPVGLRQRNQTEKQST
Sbjct: 1 MSRVAKYRRQVSEDPDIDSLLETLSPEEMEELEKELDVVDPDGSVPVGLRQRNQTEKQST 60
Query: 61 GVYNREAMLNFCEKETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSD 120
GVYNREAMLNFCEKETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSD
Sbjct: 61 GVYNREAMLNFCEKETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSD 120
Query: 121 LGKEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEE 180
LGKEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEE
Sbjct: 121 LGKEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEE 180
Query: 181 RAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMK 240
RAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMK
Sbjct: 181 RAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMK 240
Query: 241 RAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPT 300
RAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPT
Sbjct: 241 RAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPT 300
Query: 301 KPSEGPAKVEEEAAPSIFDEPLERVKNNDPEMTEVNVNNSDCITNEILVRFTEALEFNTV 360
KPSEGPAKVEEEAAPSIFDEPLERVKNNDPEMTEVNVNNSDCITNEILVRFTEALEFNTV
Sbjct: 301 KPSEGPAKVEEEAAPSIFDEPLERVKNNDPEMTEVNVNNSDCITNEILVRFTEALEFNTV 360
Query: 361 VKLFALANTRADDHVAFAIAIMLKANKTITSLNLDSNHITGKGILAIFRALLQNNTLTEL 420
VKLFALANTRADDHVAFAIAIMLKANKTITSLNLDSNHITGKGILAIFRALLQNNTLTEL
Sbjct: 361 VKLFALANTRADDHVAFAIAIMLKANKTITSLNLDSNHITGKGILAIFRALLQNNTLTEL 420
Query: 421 RFHNQRHICGGKTEMEIAKLLKENTTLLKLGYHFELAGPRMTVTNLLSRNMDKQRQKRLQ 480
RFHNQRHICGGKTEMEIAKLLKENTTLLKLGYHFELAGPRMTVTNLLSRNMDKQRQKRLQ
Sbjct: 421 RFHNQRHICGGKTEMEIAKLLKENTTLLKLGYHFELAGPRMTVTNLLSRNMDKQRQKRLQ 480
Query: 481 EQRQAQEAKGEKKDLLEVPKAGAVAKGSPKPSPQPSPKPSPKNSPKKGGAPAAPPPPPPP 540
EQRQAQEAKGEKKDLLEVPKAGAVAKGSPKPSPQPSPKPSPKNSPKKGGAPAAPPPPPPP
Sbjct: 481 EQRQAQEAKGEKKDLLEVPKAGAVAKGSPKPSPQPSPKPSPKNSPKKGGAPAAPPPPPPP 540
Query: 541 LAPPLIMENLKNSLSPATQRKMGDKVLPAQEKNSRDQLLAAIRSSNLKQLKKVEVPKLLQ 600
LAPPLIMENLKNSLSPATQRKMGDKVLPAQEKNSRDQLLAAIRSSNLKQLKKVEVPKLLQ
Sbjct: 541 LAPPLIMENLKNSLSPATQRKMGDKVLPAQEKNSRDQLLAAIRSSNLKQLKKVEVPKLLQ 600
>gi|150378503 leiomodin 2 (cardiac) [Homo sapiens]
Length = 547
Score = 295 bits (755), Expect = 8e-80
Identities = 203/556 (36%), Positives = 284/556 (51%), Gaps = 97/556 (17%)
Query: 127 RGGLKKSFSRDRDEA-GGKSGEKPKE-EKIIRGIDKGR-------VRAAVDKKEAGKDGR 177
R GL K S D DE S E+ KE E+ + I+ R ++ +K G R
Sbjct: 7 RRGLSKYESIDEDELLASLSAEELKELERELEDIEPDRNLPVGLRQKSLTEKTPTGTFSR 66
Query: 178 GEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGE 237
A K+ ++ +R + + K E +E+ E + +V E T +E E
Sbjct: 67 EALMAYWEKESQKLLEKERLGECGKVAEDKEESEEELIFTESNSEVSEE---VYTEEEEE 123
Query: 238 KMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQ--- 294
+ + D +E+ ++ G T ++ D+SK K + Q
Sbjct: 124 ESQEEEEEEDSDEEERTIETAKGINGTVN-----------YDSVNSDNSKPKIFKSQIEN 172
Query: 295 ---TPSGPTKPSEGPAKVEEEAAPSIFDEPLERVKNNDPEMTEVNVNNSDCITNEILVRF 351
T + +E PA + P++ ++ L+++K+NDP+ TEVN+NN + IT + L RF
Sbjct: 173 INLTNGSNGRNTESPAAIHPCGNPTVIEDALDKIKSNDPDTTEVNLNNIENITTQTLTRF 232
Query: 352 TEALEFNTVVKLFALANTRADDHVAFAIAIMLKANKTITSLNLDSNHITGKGILAIFRAL 411
EAL+ NTVVK F+LANT ADD A AIA MLK N+ IT++N++SN ITGKGILAI RAL
Sbjct: 233 AEALKDNTVVKTFSLANTHADDSAAMAIAEMLKVNEHITNVNVESNFITGKGILAIMRAL 292
Query: 412 LQNNTLTELRFHNQRHICGGKTEMEIAKLLKENTTLLKLGYHFELAGPRMTVTNLLSRNM 471
N LTELRFHNQRHI G + EMEI KLLKENTTLL+LGYHFEL GPRM++T++L+RNM
Sbjct: 293 QHNTVLTELRFHNQRHIMGSQVEMEIVKLLKENTTLLRLGYHFELPGPRMSMTSILTRNM 352
Query: 472 DKQRQKRLQEQRQAQEAKGEKKDLLEVPKAGAVAKG---SPKPSPQPSPK---------- 518
DKQRQKRLQEQ+Q + G +V + G + SP+ SP SPK
Sbjct: 353 DKQRQKRLQEQKQQEGYDGGPNLRTKVWQRGTPSSSPYVSPRHSPWSSPKLPKKVQTVRS 412
Query: 519 -----------PSPKNSPKKGGAPAAPPPPPPPLAPPL---------------------- 545
P P P + PPPPPPP PPL
Sbjct: 413 RPLSPVATPPPPPPPPPPPPPSSQRLPPPPPPP-PPPLPEKKLITRNIAEVIKQQESAQR 471
Query: 546 --------------------IMENLKNSLSPATQRKMGDKVLPA-QEKNSRDQLLAAIRS 584
I++ +KNSL ++KM D P+ ++++ + L+ AIR
Sbjct: 472 ALQNGQKKKKGKKVKKQPNSILKEIKNSLRSVQEKKMEDSSRPSTPQRSAHENLMEAIRG 531
Query: 585 SNLKQLKKVEVPKLLQ 600
S++KQLK+VEVP+ L+
Sbjct: 532 SSIKQLKRVEVPEALR 547
>gi|54607116 leiomodin 3 (fetal) [Homo sapiens]
Length = 560
Score = 277 bits (708), Expect = 2e-74
Identities = 214/641 (33%), Positives = 315/641 (49%), Gaps = 129/641 (20%)
Query: 2 SRVAKYRRQVSEDPDIDSLLETLSPEEMEELEKELDVVDPDGSVPVGLRQRNQTEKQSTG 61
SR + + E+ + D +L LS EE++EL+ E++V+ PD S+PVG+ Q++QT+K TG
Sbjct: 5 SRNSDQEELLDEEINEDEILANLSAEELKELQSEMEVMAPDPSLPVGMIQKDQTDKPPTG 64
Query: 62 VYNREAMLNFCEKETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDL 121
+N ++++++ E K +R + + K++ K EE
Sbjct: 65 NFNHKSLVDYMYWE--KASRRMLEEERVPVTFVKSEEKTQEEH----------------- 105
Query: 122 GKEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEER 181
+ E K+ + +EK+ I +K+E+ +G
Sbjct: 106 ---------------EEIEKRNKNMAQYLKEKLNNEI-------VANKRES----KGSSN 139
Query: 182 AVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKR 241
T +E+E++ D + D ++ EE +E++ K K + RN +
Sbjct: 140 IQETDEEDEEEEDDDDDDEGEDDGEESEE----TNREEEGKAKEQIRNCE---------- 185
Query: 242 AGGNTDMKKEDEKVKRGTGNTDTKKDDEK-VKKNEPLHEKEAKDDSKTKTPEKQTPSGPT 300
N + D+ K + ++ EK + K +P +K A D S K + PSG
Sbjct: 186 ---NNCQQVTDKAFKEQRDRPEAQEQSEKKISKLDP--KKLALDTSFLKVSTR--PSGNQ 238
Query: 301 KPSEGPAKVEEEAAPSIFDEPLERVKNNDPEMTEVNVNNSDCITNEILVRFTEALEFNTV 360
+G L RV+ NDP+M E+N+NN + I E+L+ F A++ N
Sbjct: 239 TDLDGS---------------LRRVRKNDPDMKELNLNNIENIPKEMLLDFVNAMKKNKH 283
Query: 361 VKLFALANTRADDHVAFAIAIMLKANKTITSLNLDSNHITGKGILAIFRALLQNNTLTEL 420
+K F+LAN AD++VAFA+A ML+ N++IT+LN++SN ITGKGI+AI R L N TLTEL
Sbjct: 284 IKTFSLANVGADENVAFALANMLRENRSITTLNIESNFITGKGIVAIMRCLQFNETLTEL 343
Query: 421 RFHNQRHICGGKTEMEIAKLLKENTTLLKLGYHFELAGPRMTVTNLLSRNMDKQRQKRLQ 480
RFHNQRH+ G EMEIA+LLK N TLLK+GYHFEL GPRM VTNLL+RN DKQRQKR +
Sbjct: 344 RFHNQRHMLGHHAEMEIARLLKANNTLLKMGYHFELPGPRMVVTNLLTRNQDKQRQKRQE 403
Query: 481 EQRQAQEAKGEKKDL------LEVPKAGAVAKGSPKP--------SPQPSPKPSPKNSP- 525
EQ+Q Q+ K +KK + L +P G PKP P P P+P+N P
Sbjct: 404 EQKQ-QQLKEQKKLIAMLENGLGLPPGMWELLGGPKPDSRMQEFFQPPPPRPPNPQNVPF 462
Query: 526 --------KKGGAPAAPPPPP----------------PPLAPPLIMENLKN---SLSPAT 558
K AP P P P NLK+ +L P
Sbjct: 463 SQRSEMMKKPSQAPKYRTDPDSFRVVKLKRIQRKSRMPEAREPPEKTNLKDVIKTLKPVP 522
Query: 559 QRKMGDKVLPAQEKNSRDQLLAAIRSSNLKQLKKVEVPKLL 599
+ ++ P E RDQLL IR S++ LK V++PK L
Sbjct: 523 R----NRPPPLVEITPRDQLLNDIRHSSVAYLKPVQLPKEL 559
>gi|7657647 neuronal tropomodulin isoform a [Homo sapiens]
Length = 351
Score = 163 bits (413), Expect = 4e-40
Identities = 94/212 (44%), Positives = 130/212 (61%), Gaps = 6/212 (2%)
Query: 274 NEPLHEKEAKDDSKTKTPEKQTPSGP-TKPSEGPAKVEEEAAPSIFDEPLERVKNNDPEM 332
N P ++E ++ K P + G KP EE P+ + L+++K NDP +
Sbjct: 145 NNPKFDEETANNKGGKGPVRNVVKGEKVKPV-----FEEPPNPTNVEISLQQMKANDPSL 199
Query: 333 TEVNVNNSDCITNEILVRFTEALEFNTVVKLFALANTRADDHVAFAIAIMLKANKTITSL 392
EVN+NN I L F +ALE NT VK F+LA TR++D VA A A MLK NKT+TSL
Sbjct: 200 QEVNLNNIKNIPIPTLREFAKALETNTHVKKFSLAATRSNDPVAIAFADMLKVNKTLTSL 259
Query: 393 NLDSNHITGKGILAIFRALLQNNTLTELRFHNQRHICGGKTEMEIAKLLKENTTLLKLGY 452
N++SN ITG GILA+ AL +N+TLTE++ NQR G EMEIA++L+EN+ +LK GY
Sbjct: 260 NIESNFITGTGILALVEALKENDTLTEIKIDNQRQQLGTAVEMEIAQMLEENSRILKFGY 319
Query: 453 HFELAGPRMTVTNLLSRNMDKQRQKRLQEQRQ 484
F GPR V +++N D R+KR++ R+
Sbjct: 320 QFTKQGPRTRVAAAITKNNDLVRKKRVEADRR 351
Score = 62.8 bits (151), Expect = 9e-10
Identities = 46/159 (28%), Positives = 77/159 (48%), Gaps = 18/159 (11%)
Query: 16 DIDSLLETLSPEEMEELEKELDVVDPDGSV-PVGLRQRNQTEKQSTGVYNREAMLNFCEK 74
D D LL LS EE+++LE LD +DP+ ++ P G RQ++QT+K +TG ++RE +L + EK
Sbjct: 16 DEDELLGKLSEEELKQLENVLDDLDPESAMLPAGFRQKDQTQKAATGPFDREHLLMYLEK 75
Query: 75 ETKKLMQRE------------MSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLG 122
E + RE + + + K +ET+ + K + + + + DL
Sbjct: 76 EALEQKDREDFVPFTGEKKGRVFIPKEKPIETRKEEKVTLDPELEEALASASDTELYDLA 135
Query: 123 KEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKG 161
L + D + A K G+ P +R + KG
Sbjct: 136 AVLGVHNLLNNPKFDEETANNKGGKGP-----VRNVVKG 169
>gi|4507553 tropomodulin 1 [Homo sapiens]
Length = 359
Score = 156 bits (394), Expect = 6e-38
Identities = 82/196 (41%), Positives = 121/196 (61%)
Query: 286 SKTKTPEKQTPSGPTKPSEGPAKVEEEAAPSIFDEPLERVKNNDPEMTEVNVNNSDCITN 345
S + K+ + KP++ +EE + +E LER+KNNDP++ EVN+NN I
Sbjct: 151 SSSSIMNKEGLNSVIKPTQYKPVPDEEPNSTDVEETLERIKNNDPKLEEVNLNNIRNIPI 210
Query: 346 EILVRFTEALEFNTVVKLFALANTRADDHVAFAIAIMLKANKTITSLNLDSNHITGKGIL 405
L + EAL+ N+ VK F++ TR++D VA+A+A MLK NK + +LN++SN I+G GIL
Sbjct: 211 PTLKAYAEALKENSYVKKFSIVGTRSNDPVAYALAEMLKENKVLKTLNVESNFISGAGIL 270
Query: 406 AIFRALLQNNTLTELRFHNQRHICGGKTEMEIAKLLKENTTLLKLGYHFELAGPRMTVTN 465
+ AL N +L E++ NQ G K EMEI +L++N TLLK GYHF GPR+ +N
Sbjct: 271 RLVEALPYNTSLVEMKIDNQSQPLGNKVEMEIVSMLEKNATLLKFGYHFTQQGPRLRASN 330
Query: 466 LLSRNMDKQRQKRLQE 481
+ N D R++RL +
Sbjct: 331 AMMNNNDLVRKRRLAD 346
Score = 68.6 bits (166), Expect = 2e-11
Identities = 36/80 (45%), Positives = 52/80 (65%), Gaps = 3/80 (3%)
Query: 7 YRRQVSE--DPDIDSLLETLSPEEMEELEKELDVVDPDGSV-PVGLRQRNQTEKQSTGVY 63
YRR++ + D D D +L L+ EE+ LE ELD +DPD ++ P GLRQ++QT K TG +
Sbjct: 3 YRRELEKYRDLDEDEILGALTEEELRTLENELDELDPDNALLPAGLRQKDQTTKAPTGPF 62
Query: 64 NREAMLNFCEKETKKLMQRE 83
RE +L+ EK+ K+ RE
Sbjct: 63 KREELLDHLEKQAKEFKDRE 82
>gi|7657649 tropomodulin 3 (ubiquitous) [Homo sapiens]
Length = 352
Score = 155 bits (391), Expect = 1e-37
Identities = 84/175 (48%), Positives = 111/175 (63%)
Query: 310 EEEAAPSIFDEPLERVKNNDPEMTEVNVNNSDCITNEILVRFTEALEFNTVVKLFALANT 369
+E P+ +E L+R K ND + EVN+NN I L F +ALE NT VK F+LA T
Sbjct: 178 DEPPNPTNVEESLKRTKENDAHLVEVNLNNIKNIPIPTLKDFAKALETNTHVKCFSLAAT 237
Query: 370 RADDHVAFAIAIMLKANKTITSLNLDSNHITGKGILAIFRALLQNNTLTELRFHNQRHIC 429
R++D VA A A MLK NKT+ SLN++SN ITG GILA+ AL N TL EL+ NQR
Sbjct: 238 RSNDPVATAFAEMLKVNKTLKSLNVESNFITGVGILALIDALRDNETLAELKIDNQRQQL 297
Query: 430 GGKTEMEIAKLLKENTTLLKLGYHFELAGPRMTVTNLLSRNMDKQRQKRLQEQRQ 484
G E+E+AK+L+ENT +LK GY F GPR N +++N D R++R++ Q
Sbjct: 298 GTAVELEMAKMLEENTNILKFGYQFTQQGPRTRAANAITKNNDLVRKRRVEGDHQ 352
Score = 62.8 bits (151), Expect = 9e-10
Identities = 32/72 (44%), Positives = 48/72 (66%), Gaps = 1/72 (1%)
Query: 13 EDPDIDSLLETLSPEEMEELEKELDVVDPDGSV-PVGLRQRNQTEKQSTGVYNREAMLNF 71
+D D D LL LS E+++LE LD +DP+ ++ P G RQ+NQT K +TG ++RE +L++
Sbjct: 13 KDLDEDELLGNLSETELKQLETVLDDLDPENALLPAGFRQKNQTSKSTTGPFDREHLLSY 72
Query: 72 CEKETKKLMQRE 83
EKE + RE
Sbjct: 73 LEKEALEHKDRE 84
>gi|156415984 tropomodulin 4 (muscle) [Homo sapiens]
Length = 345
Score = 136 bits (343), Expect = 5e-32
Identities = 70/182 (38%), Positives = 115/182 (63%)
Query: 297 SGPTKPSEGPAKVEEEAAPSIFDEPLERVKNNDPEMTEVNVNNSDCITNEILVRFTEALE 356
S +P + +E P+ +E L+RV++ND E+ EVN+NN I +L EA++
Sbjct: 162 SSVVQPDKYKPVPDEPPNPTNIEEILKRVRSNDKELEEVNLNNIQDIPIPMLSELCEAMK 221
Query: 357 FNTVVKLFALANTRADDHVAFAIAIMLKANKTITSLNLDSNHITGKGILAIFRALLQNNT 416
NT V+ F+L TR+ D +A A+A ML+ N+++ SLN++SN I+ G++A+ +A+ +N T
Sbjct: 222 ANTYVRSFSLVATRSGDPIANAVADMLRENRSLQSLNIESNFISSTGLMAVLKAVRENAT 281
Query: 417 LTELRFHNQRHICGGKTEMEIAKLLKENTTLLKLGYHFELAGPRMTVTNLLSRNMDKQRQ 476
LTELR NQR G EME+A +L++ ++++ GYHF GPR ++RN + +RQ
Sbjct: 282 LTELRVDNQRQWPGDAVEMEMATVLEQCPSIVRFGYHFTQQGPRARAAQAMTRNNELRRQ 341
Query: 477 KR 478
++
Sbjct: 342 QK 343
Score = 69.7 bits (169), Expect = 7e-12
Identities = 34/83 (40%), Positives = 59/83 (71%), Gaps = 3/83 (3%)
Query: 4 VAKYRRQVSE--DPDIDSLLETLSPEEMEELEKELDVVDPDGSV-PVGLRQRNQTEKQST 60
++ Y++++ + D D D +L TLSPEE+E+L+ EL +DP+ + P GLRQR+QT+K T
Sbjct: 1 MSSYQKELEKYRDIDEDEILRTLSPEELEQLDCELQEMDPENMLLPAGLRQRDQTKKSPT 60
Query: 61 GVYNREAMLNFCEKETKKLMQRE 83
G +REA+L + E++ ++ +R+
Sbjct: 61 GPLDREALLQYLEQQALEVKERD 83
>gi|218931148 neuronal tropomodulin isoform b [Homo sapiens]
Length = 315
Score = 120 bits (301), Expect = 4e-27
Identities = 77/212 (36%), Positives = 110/212 (51%), Gaps = 42/212 (19%)
Query: 274 NEPLHEKEAKDDSKTKTPEKQTPSGP-TKPSEGPAKVEEEAAPSIFDEPLERVKNNDPEM 332
N P ++E ++ K P + G KP EE P+ + L+++K NDP +
Sbjct: 145 NNPKFDEETANNKGGKGPVRNVVKGEKVKPV-----FEEPPNPTNVEISLQQMKANDPSL 199
Query: 333 TEVNVNNSDCITNEILVRFTEALEFNTVVKLFALANTRADDHVAFAIAIMLKANKTITSL 392
EVN+NN +K FA MLK NKT+TSL
Sbjct: 200 QEVNLNN---------------------IKAFA---------------DMLKVNKTLTSL 223
Query: 393 NLDSNHITGKGILAIFRALLQNNTLTELRFHNQRHICGGKTEMEIAKLLKENTTLLKLGY 452
N++SN ITG GILA+ AL +N+TLTE++ NQR G EMEIA++L+EN+ +LK GY
Sbjct: 224 NIESNFITGTGILALVEALKENDTLTEIKIDNQRQQLGTAVEMEIAQMLEENSRILKFGY 283
Query: 453 HFELAGPRMTVTNLLSRNMDKQRQKRLQEQRQ 484
F GPR V +++N D R+KR++ R+
Sbjct: 284 QFTKQGPRTRVAAAITKNNDLVRKKRVEADRR 315
Score = 62.8 bits (151), Expect = 9e-10
Identities = 46/159 (28%), Positives = 77/159 (48%), Gaps = 18/159 (11%)
Query: 16 DIDSLLETLSPEEMEELEKELDVVDPDGSV-PVGLRQRNQTEKQSTGVYNREAMLNFCEK 74
D D LL LS EE+++LE LD +DP+ ++ P G RQ++QT+K +TG ++RE +L + EK
Sbjct: 16 DEDELLGKLSEEELKQLENVLDDLDPESAMLPAGFRQKDQTQKAATGPFDREHLLMYLEK 75
Query: 75 ETKKLMQRE------------MSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLG 122
E + RE + + + K +ET+ + K + + + + DL
Sbjct: 76 EALEQKDREDFVPFTGEKKGRVFIPKEKPIETRKEEKVTLDPELEEALASASDTELYDLA 135
Query: 123 KEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKG 161
L + D + A K G+ P +R + KG
Sbjct: 136 AVLGVHNLLNNPKFDEETANNKGGKGP-----VRNVVKG 169
>gi|239749449 PREDICTED: hypothetical protein [Homo sapiens]
Length = 275
Score = 83.2 bits (204), Expect = 6e-16
Identities = 65/239 (27%), Positives = 107/239 (44%), Gaps = 30/239 (12%)
Query: 64 NREAMLNFCEKETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGK 123
N E + C +K QRE + ++ K + +ER R+ KK R+ + GK
Sbjct: 14 NTELQMVSCSHISKPCTQRESERKKERREREKRKREREKERKRERGKKEKKKRKKRERGK 73
Query: 124 EPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAV 183
E +R +K + R E K K K+EK K+E + GR E +
Sbjct: 74 ERERK--RKEREKQRKERREKERRKRKKEK--------------KKRERKQRGRRERKKK 117
Query: 184 ATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAG 243
+KE E++ R R + K+R++ + +K + E+ K ER+ +KE + KR
Sbjct: 118 KERKERERENKQRR---ERKRKKRRKKKRRKERKREKERGKRERKRKKRKKEEREKKRER 174
Query: 244 GNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKP 302
+ KKE E+ +R ++ +K +K E +KE K D KT ++QT S +P
Sbjct: 175 NRKERKKERERKER--------RERKKERKKERRKKKERKKDRKT---DRQTDSQVFRP 222
Score = 47.0 bits (110), Expect = 5e-05
Identities = 41/150 (27%), Positives = 73/150 (48%), Gaps = 13/150 (8%)
Query: 169 KKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERR 228
++E K R +ER K+E+KK R G +++++KR+E +E +KE EK + +R+
Sbjct: 42 EREKRKREREKERKRERGKKEKKKRKKRERG--KERERKRKE-REKQRKERREKERRKRK 98
Query: 229 NTDTRKEGEKMKRAGGNTDMKKEDEKVKRGTGNTD-----TKKDDEKVKKNEPLHEKE-A 282
++E ++ G + KK+ E+ +R N KK +K ++ E EKE
Sbjct: 99 KEKKKRE----RKQRGRRERKKKKERKERERENKQRRERKRKKRRKKKRRKERKREKERG 154
Query: 283 KDDSKTKTPEKQTPSGPTKPSEGPAKVEEE 312
K + K K +K+ + + K E E
Sbjct: 155 KRERKRKKRKKEEREKKRERNRKERKKERE 184
Score = 42.7 bits (99), Expect = 0.001
Identities = 44/192 (22%), Positives = 82/192 (42%), Gaps = 16/192 (8%)
Query: 22 ETLSPEEMEELEKELDVVDPDGSVPVGLRQRNQTEKQSTGVYNREAMLNFCEKETKKLMQ 81
E+ +E E EK + + G +++ + +K+ G +E E+E ++ +
Sbjct: 33 ESERKKERREREKRKREREKERKRERGKKEKKKRKKRERG---KERERKRKEREKQRKER 89
Query: 82 REMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDEA 141
RE + K+ + K + K R R K+ R++ +E KR KK + R +
Sbjct: 90 REKERRKRKKEKKKRERKQRGRRERKKKKERKERERENKQRRERKR---KKRRKKKRRKE 146
Query: 142 GGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLS 201
+ E+ K E+ K + R KKE + R R K+ E K+ +R
Sbjct: 147 RKREKERGKRER------KRKKR----KKEEREKKRERNRKERKKERERKERRERKKERK 196
Query: 202 RDKDKKREEMKE 213
+++ KK+E K+
Sbjct: 197 KERRKKKERKKD 208
>gi|239754909 PREDICTED: hypothetical protein [Homo sapiens]
Length = 245
Score = 76.3 bits (186), Expect = 8e-14
Identities = 59/221 (26%), Positives = 108/221 (48%), Gaps = 19/221 (8%)
Query: 78 KLMQREMSMDESKQVETKTDAKNGEERG-RDASKKALGPRRDSDLGKEPKRGGLKKSF-- 134
++ +RE ++ K+ + + +++ +ER R+ K+ R + GK+ K+G KK
Sbjct: 37 EIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERE 96
Query: 135 -SRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKG 193
+ R E K GE+ ++ K ++GR KE + R EER +KE E+K
Sbjct: 97 RKKRRREKENKEGEEKEKRKKKEKKERGRT-----SKEGKERERKEERKREERKERERKK 151
Query: 194 SDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKKEDE 253
+R R K++K+ E K+V +KE++ K K ER+ E+ KR + KKE E
Sbjct: 152 EEREKERER-KERKKRERKQVGEKEEERKEK-ERK--------ERKKRERNRKERKKERE 201
Query: 254 KVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQ 294
+ +R + KK +E+ K+ + + ++ + K K+
Sbjct: 202 RKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKE 242
Score = 70.9 bits (172), Expect = 3e-12
Identities = 53/210 (25%), Positives = 99/210 (47%), Gaps = 10/210 (4%)
Query: 49 LRQRN-QTEKQSTGVYNREAMLNFCEKETKKLMQREMSMDESKQVETKTDAKNGEERGRD 107
+R+R + E + G RE+ +KE ++ +R+ ++ ++ E K GE + +
Sbjct: 38 IREREREIETRKEGKKERESER---KKERREREKRKREREKERKRERGKKEKKGERKKEE 94
Query: 108 ASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAV 167
+K +++ G+E ++ K+ R R GK E+ +E K ++ R +
Sbjct: 95 RERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEER 154
Query: 168 DKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGER 227
+K+ K+ + ER +KEEE+K +R + KKRE ++ KKE + K + ER
Sbjct: 155 EKERERKERKKRERKQVGEKEEERKEKERK------ERKKRERNRKERKKERERKERRER 208
Query: 228 RNTDTRKEGEKMKRAGGNTDMKKEDEKVKR 257
+ +KE K +R +E E+ KR
Sbjct: 209 KKERKKKEERKKERQKDRQTNWREKERGKR 238
Score = 56.2 bits (134), Expect = 8e-08
Identities = 43/163 (26%), Positives = 77/163 (47%), Gaps = 7/163 (4%)
Query: 177 RGEERAVATKKEEEKKGSDRNTGLSRDKDK-KREEMKEVAKKEDDEKVKGERRNTD---T 232
R ER + T+KE +K+ R+++K KRE KE ++ ++ KGER+ +
Sbjct: 39 REREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKKGERKKEERERK 98
Query: 233 RKEGEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEK-VKKNEPLHEKEAKDDSKTKTP 291
++ EK + G + +K+ EK +RG + + K+ + K +K E E+E K + + K
Sbjct: 99 KRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEEREKER 158
Query: 292 EKQTPSGPTKPSEGPAKVEEEAAPSIFDEPLERVKNNDPEMTE 334
E++ + G + EEE E +R +N E
Sbjct: 159 ERKERKKRERKQVG--EKEEERKEKERKERKKRERNRKERKKE 199
Score = 55.8 bits (133), Expect = 1e-07
Identities = 46/186 (24%), Positives = 87/186 (46%), Gaps = 13/186 (6%)
Query: 109 SKKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVD 168
SK P S++ + + +K ++R+ K E+ + EK R +K R
Sbjct: 26 SKPCTQPGWQSEIREREREIETRKEGKKERESERKK--ERREREKRKREREKER------ 77
Query: 169 KKEAGK-DGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEV-AKKEDDEKVKGE 226
K+E GK + +GE + ++++ ++ + G ++K KK+E+ + KE E+ + E
Sbjct: 78 KRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKE 137
Query: 227 RRNTDTRKEGEKMKRAGGNTDMKKEDEKVKR---GTGNTDTKKDDEKVKKNEPLHEKEAK 283
R + RKE E+ K +KE +K +R G + K+ + K +K + KE K
Sbjct: 138 ERKREERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERK 197
Query: 284 DDSKTK 289
+ + K
Sbjct: 198 KERERK 203
Score = 55.8 bits (133), Expect = 1e-07
Identities = 54/214 (25%), Positives = 98/214 (45%), Gaps = 12/214 (5%)
Query: 28 EMEELEKELDVVDPDGSVPVGLRQRNQTEKQSTGVYNREAMLNFCEKETKKLMQREMSMD 87
E+ E E+E++ R++ + E++ + K+ KK +R+
Sbjct: 37 EIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKEKK-GERKKEER 95
Query: 88 ESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGE 147
E K+ + + K GEE+ + K+ R S GKE +R +K R E + E
Sbjct: 96 ERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERKERERKKEERE 155
Query: 148 KPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKK 207
K +E K + ++ +V +K+E K+ +ER + +E+K R++ ++
Sbjct: 156 KERERKERKKRERKQVG---EKEEERKEKERKERKKRERNRKERK-------KERERKER 205
Query: 208 REEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKR 241
RE KE KKE+ +K + + R T+ R E E+ KR
Sbjct: 206 RERKKERKKKEERKKERQKDRQTNWR-EKERGKR 238
Score = 50.4 bits (119), Expect = 5e-06
Identities = 51/175 (29%), Positives = 84/175 (48%), Gaps = 14/175 (8%)
Query: 50 RQRNQTEKQSTGVYN---REAMLNFCEKETKKLMQREMSMDESKQVETKTDAKNGEERGR 106
R+R + +K+ G RE EKE K+ ++E + K+ +T +K G+ER R
Sbjct: 77 RKRERGKKEKKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRT-SKEGKERER 135
Query: 107 DASKKALGPRRDSDLGKEP--KRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVR 164
+K R++ + KE K K+ R+R + G K E+ ++E+ R K R R
Sbjct: 136 KEERKR-EERKERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKER---KKRER 191
Query: 165 AAVDKKEAGKDGRGEERAVATKKEEEKK---GSDRNTGLSRDKDKKREEMKEVAK 216
++K+ + ER KK+EE+K DR T R+K++ + E KE K
Sbjct: 192 NRKERKKERERKERRERKKERKKKEERKKERQKDRQTNW-REKERGKRERKERKK 245
Score = 48.9 bits (115), Expect = 1e-05
Identities = 40/182 (21%), Positives = 85/182 (46%), Gaps = 4/182 (2%)
Query: 135 SRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAG-KDGRGEERAVATKKE---EE 190
S+ + G +S + +E +I + + R + KKE ++ R ER K+E +E
Sbjct: 26 SKPCTQPGWQSEIREREREIETRKEGKKERESERKKERREREKRKREREKERKRERGKKE 85
Query: 191 KKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKK 250
KKG + R K ++ +E KE +KE +K + + R +++ E+ ++ + +K
Sbjct: 86 KKGERKKEERERKKRRREKENKEGEEKEKRKKKEKKERGRTSKEGKERERKEERKREERK 145
Query: 251 EDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEGPAKVE 310
E E+ K +K+ +K ++ + ++E + + + K +K+ + + E K
Sbjct: 146 ERERKKEEREKERERKERKKRERKQVGEKEEERKEKERKERKKRERNRKERKKERERKER 205
Query: 311 EE 312
E
Sbjct: 206 RE 207
Score = 47.4 bits (111), Expect = 4e-05
Identities = 39/179 (21%), Positives = 81/179 (45%), Gaps = 5/179 (2%)
Query: 50 RQRNQTEKQSTGVYNREAMLNFCEKETKKLMQREMSMDESKQVETKTDAKNGEERGRDAS 109
R+R + K+ G ++ E+E KK +RE E ++ E K K +ERGR +
Sbjct: 71 REREKERKRERGKKEKKGERKKEERERKK-RRREKENKEGEEKE-KRKKKEKKERGRTSK 128
Query: 110 KKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDK 169
+ R++ +E K KK +R++ + K +E K + ++ R +
Sbjct: 129 EGKERERKEERKREERKERERKKE---EREKERERKERKKRERKQVGEKEEERKEKERKE 185
Query: 170 KEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERR 228
++ + R E + +KE ++ +R R K+++++ +KE ++ + ER+
Sbjct: 186 RKKRERNRKERKKERERKERRERKKERKKKEERKKERQKDRQTNWREKERGKRERKERK 244
>gi|4557509 cylicin 2 [Homo sapiens]
Length = 348
Score = 74.7 bits (182), Expect = 2e-13
Identities = 78/274 (28%), Positives = 124/274 (45%), Gaps = 31/274 (11%)
Query: 47 VGLRQRNQTEKQSTGVYNREAMLNFCEKETKKLMQREMSMDESKQVETKTDAKNGEERGR 106
V L R Q K + V +K K Q++ + ES+ + K D+K G++ +
Sbjct: 90 VYLAARRQPLKPTRTVEVDSKAAEIGKKGEDKTTQKDTTDSESELKQGKKDSKKGKDIEK 149
Query: 107 DASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAA 166
+K L ++DS GK+ G K S + DE GG + K++K +KG+ A
Sbjct: 150 GKEEK-LDAKKDSKKGKKDAEKG-KDSATESEDEKGGAKKDNKKDKK---DSNKGKDSAT 204
Query: 167 VDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDK--DKKREEMKEVAKKEDDEKVK 224
+ E G G E+ K++ KKG D L K +KK E+ K+ A K D+ K
Sbjct: 205 ESEGEKG----GTEKDSKKGKKDSKKGKDSAIELQAVKADEKKDEDGKKDANKGDESK-- 258
Query: 225 GERRNTDTRKEGEKMKRAGGNTD------MKKEDEKVKRGTGNTDTKKDDEKVKKNEPLH 278
+++ K+G+K K+ +TD +KKE +K D KD +KV K +
Sbjct: 259 DAKKDAKEIKKGKKDKKKPSSTDSDSKDDVKKESKK--------DATKDAKKVAKKDT-- 308
Query: 279 EKEAKDDSKTKTPEKQTPSGPTKPSEGPAKVEEE 312
EKE+ D K +K K ++ AK +E+
Sbjct: 309 EKESADSK--KDAKKNAKKDAKKDAKKNAKKDEK 340
Score = 46.2 bits (108), Expect = 9e-05
Identities = 35/149 (23%), Positives = 63/149 (42%), Gaps = 7/149 (4%)
Query: 74 KETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLKKS 133
K++ + E E + K D+K G++ + ++D D K+ +G K
Sbjct: 200 KDSATESEGEKGGTEKDSKKGKKDSKKGKDSAIELQAVKADEKKDEDGKKDANKGDESKD 259
Query: 134 FSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDG-----RGEERAVATKKE 188
+D E K G+K K++ D KK+A KD + E+ A K+
Sbjct: 260 AKKDAKEI--KKGKKDKKKPSSTDSDSKDDVKKESKKDATKDAKKVAKKDTEKESADSKK 317
Query: 189 EEKKGSDRNTGLSRDKDKKREEMKEVAKK 217
+ KK + ++ K+ K++E K+ KK
Sbjct: 318 DAKKNAKKDAKKDAKKNAKKDEKKDAKKK 346
Score = 40.4 bits (93), Expect = 0.005
Identities = 35/146 (23%), Positives = 61/146 (41%), Gaps = 10/146 (6%)
Query: 191 KKGSDRNTGLSRDKDKKREEMKEVAK--KEDDEKVKGERRNTDTRKEGEKMKR---AGGN 245
KKG D+ T +D E+K+ K K+ + KG+ D +K+ +K K+ G +
Sbjct: 116 KKGEDKTT--QKDTTDSESELKQGKKDSKKGKDIEKGKEEKLDAKKDSKKGKKDAEKGKD 173
Query: 246 TDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEG 305
+ + EDEK G D KKD + K + + + T+ K+ K +
Sbjct: 174 SATESEDEK---GGAKKDNKKDKKDSNKGKDSATESEGEKGGTEKDSKKGKKDSKKGKDS 230
Query: 306 PAKVEEEAAPSIFDEPLERVKNNDPE 331
+++ A DE ++ N E
Sbjct: 231 AIELQAVKADEKKDEDGKKDANKGDE 256
Score = 32.0 bits (71), Expect = 1.7
Identities = 34/141 (24%), Positives = 53/141 (37%), Gaps = 21/141 (14%)
Query: 170 KEAGKDGRGEERAVATKKEEEKKGSDRNT-----GLSRDKDK-------KREEMKEVAKK 217
K K + + V+ EE+ +G R L R ++ +R+ +K
Sbjct: 46 KRRSKPSQIRDNTVSIIDEEQLRGDRRQPLWMYRSLMRISERPSVYLAARRQPLKPTRTV 105
Query: 218 EDDEKV-----KGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVK 272
E D K KGE + T + + G D KK + K D KKD +K K
Sbjct: 106 EVDSKAAEIGKKGEDKTTQKDTTDSESELKQGKKDSKKGKDIEKGKEEKLDAKKDSKKGK 165
Query: 273 KNEPLHEKEAKDDSKTKTPEK 293
K+ ++ KD + EK
Sbjct: 166 KD----AEKGKDSATESEDEK 182
>gi|55741709 RNA binding motif protein 25 [Homo sapiens]
Length = 843
Score = 72.4 bits (176), Expect = 1e-12
Identities = 80/335 (23%), Positives = 140/335 (41%), Gaps = 28/335 (8%)
Query: 9 RQVSEDPDIDSLLETLSPEEMEELEKELDVVDPDGSVPVGLRQRNQTEKQSTGVYNREAM 68
R++S+ D LE EE + EKE ++ + R+R + ++ RE
Sbjct: 279 REISKFRDTHKKLE----EEKGKKEKERQEIEKERRERERERERERERRERERERERER- 333
Query: 69 LNFCEKETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRG 128
E+E +K +RE D + + D ER RD ++ R SD K+ R
Sbjct: 334 ----EREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRE-----RSSDRNKDRSRS 384
Query: 129 GLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGR-----GEERAV 183
K SRDR+ + E+ +E + R ++ R R ++E KD + EE A
Sbjct: 385 REK---SRDREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAY 441
Query: 184 ATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAG 243
+K E K R K+ + E K+ + E + + + ERR + KE +++K
Sbjct: 442 ERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKEAEREEERRR-EMAKEAKRLKEFL 500
Query: 244 GNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPS 303
+ D ++D K RG+ +D EK + + K K++ + + ++ G P
Sbjct: 501 EDYDDDRDDPKYYRGSALQKRLRDREKEMEADERDRKREKEELE-EIRQRLLAEGHPDPD 559
Query: 304 EGPAKVEEEA----APSIFDEPLERVKNNDPEMTE 334
++E+EA P I EP + + + E
Sbjct: 560 AELQRMEQEAERRRQPQIKQEPESEEEEEEKQEKE 594
Score = 58.2 bits (139), Expect = 2e-08
Identities = 53/208 (25%), Positives = 98/208 (47%), Gaps = 17/208 (8%)
Query: 123 KEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERA 182
+E KR + + S+ RD EK K+EK + I+K R R ++E ++ R ER
Sbjct: 270 EEDKRDLISREISKFRDTHKKLEEEKGKKEKERQEIEKER-RERERERERERERRERERE 328
Query: 183 VATKKEEEK-KGSDRNTGLSRDKDKKREEMKEVAKK--EDDEKVKGERRNTDTRKEGEKM 239
++E EK K +R RD+D+ +E ++ ++ D ++ + RN D + EK
Sbjct: 329 REREREREKEKERERERERDRDRDRTKERDRDRDRERDRDRDRERSSDRNKDRSRSREKS 388
Query: 240 KRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGP 299
+ D ++E E+ + + +++ E+ ++ E E+E + D K E + +
Sbjct: 389 R------DREREREREREREREREREREREREREREREREREREKDKKRDREEDEEDAYE 442
Query: 300 TKPSEGPAKVEEEAAPSIFDEPLERVKN 327
+ E + E+EAA ER+KN
Sbjct: 443 RRKLERKLR-EKEAAYQ------ERLKN 463
Score = 57.8 bits (138), Expect = 3e-08
Identities = 48/224 (21%), Positives = 109/224 (48%), Gaps = 17/224 (7%)
Query: 73 EKETKKLMQREMSM--DESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGL 130
E++ + L+ RE+S D K++E + K +E+ R +K RR+ + +E +R
Sbjct: 270 EEDKRDLISREISKFRDTHKKLE---EEKGKKEKERQEIEKE---RRERERERERERERR 323
Query: 131 KKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEE 190
++ R+R+ K E+ +E + R D+ + R +E +D R ER+ + + ++
Sbjct: 324 EREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRD-RDRERS-SDRNKDR 381
Query: 191 KKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKK 250
+ +++ R+++++RE +E ++ + E+ + R + +E +K + ++
Sbjct: 382 SRSREKSRDREREREREREREREREREREREREREREREREREREKDKKRD-------RE 434
Query: 251 EDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQ 294
EDE+ + K +++ E L E ++ KT+ EK+
Sbjct: 435 EDEEDAYERRKLERKLREKEAAYQERLKNWEIRERKKTREYEKE 478
Score = 45.4 bits (106), Expect = 1e-04
Identities = 47/252 (18%), Positives = 110/252 (43%), Gaps = 26/252 (10%)
Query: 87 DESKQVETKTDAKNGEERG------RDASKKALGPRRDSDLGKEPKRGGLKKSFSR---- 136
D+ + ++ +T ++ +G R+ S + P ++SD K+ K+ R
Sbjct: 191 DDEEALDEETKRRDQMIKGAIEVLIREYSSELNAPSQESDSHPRKKKKEKKEDIFRRFPV 250
Query: 137 ---------DRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKK 187
+++ E+ K + I R I K R ++E GK + +ER K+
Sbjct: 251 APLIPYPLITKEDINAIEMEEDKRDLISREISKFRDTHKKLEEEKGK--KEKERQEIEKE 308
Query: 188 EEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKE--GEKMKRAGGN 245
E++ R+++++RE +E K+++ E+ + R+ D KE ++ + +
Sbjct: 309 RRERERERERERERREREREREREREREKEKERERERERDRDRDRTKERDRDRDRERDRD 368
Query: 246 TDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKE---AKDDSKTKTPEKQTPSGPTKP 302
D ++ ++ K + + + +D E+ ++ E E+E ++ + + E++ K
Sbjct: 369 RDRERSSDRNKDRSRSREKSRDREREREREREREREREREREREREREREREREREREKD 428
Query: 303 SEGPAKVEEEAA 314
+ + +EE A
Sbjct: 429 KKRDREEDEEDA 440
>gi|117935038 cylicin, basic protein of sperm head cytoskeleton 1
[Homo sapiens]
Length = 651
Score = 70.5 bits (171), Expect = 4e-12
Identities = 69/275 (25%), Positives = 123/275 (44%), Gaps = 45/275 (16%)
Query: 94 TKTDAKNGEERGRDA-SKKALGPRRDSD-LGKEPKRGGLKKSFSRDRDEAGGKSGEKPKE 151
TK D K ++ DA S+ + ++DS + K K+ KK +D + +SG+ E
Sbjct: 284 TKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAESGDSKDE 343
Query: 152 EKIIRGIDKGRVRAAVDKKEA-------------GKDGRGEERAV--ATKKEEEKKGSDR 196
K + DK +++ KK+ KD R + R + A+K +++KK + +
Sbjct: 344 RKDTKK-DKKKLKKDDKKKDTKKYPESTDTESGDAKDARNDSRNLKKASKNDDKKKDAKK 402
Query: 197 NTGL--------SRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDM 248
T S++ K ++ K+ +K ++ + VK + +TD E + G++
Sbjct: 403 ITFSTDSESELESKESQKDEKKDKKDSKTDNKKSVKNDEESTDADSEPK------GDSKK 456
Query: 249 KKEDEKVKRGTGNTDTKKDDEK--VKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEGP 306
K+DEK G D+KKDD+K KKN E E+ + K + G K +
Sbjct: 457 GKKDEK----KGKKDSKKDDKKKDAKKNAESTEMESDLELKKDKKHSKEKKGSKKDIKKD 512
Query: 307 AKVEEEAAPSIFDEPLE-------RVKNNDPEMTE 334
A+ + E+ + FDE + ++K +D E E
Sbjct: 513 ARKDTESTDAEFDESSKTGFKTSTKIKGSDTESEE 547
Score = 58.9 bits (141), Expect = 1e-08
Identities = 108/529 (20%), Positives = 204/529 (38%), Gaps = 51/529 (9%)
Query: 40 DPDGSVPVGLRQRNQTEKQSTGVY----NREAMLNFCEKETKKLMQREMSMDESKQVETK 95
+P+ V + + Q E T + N ++ + ET Q ++ ++ + K
Sbjct: 141 NPESKQIVEEKTKRQNEADKTPLKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQKDK 200
Query: 96 TDAKNGEERGRDASKKALGPRRD---SDLGKEP-----KRGGLKKSFSRDRDEAGGKSGE 147
D+KN ++ + P++D S +P L F G E
Sbjct: 201 KDSKNSKKTNTEFLHTKNNPKKDLKRSKTSNDPISEICSENSLNVDFLM---LVGQSDDE 257
Query: 148 KPKEEKIIRGIDKGRVR------AAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLS 201
+ +R + + KK+ K+ + A + ++ KK S + +
Sbjct: 258 SINFDAWLRNYSQNNSKNYSLKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDS-KKVKKN 316
Query: 202 RDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVKRGTGN 261
KD K++++K+ + D E + DT+K+ +K+K+ D KK E +
Sbjct: 317 VKKDDKKKDVKKDTESTDAESGDSKDERKDTKKDKKKLKKDDKKKDTKKYPE-------S 369
Query: 262 TDTKKDDEKVKKNEPLHEKEA-KDDSKTKTPEKQTPSGPTKPSEGPAKVEEEAAPSIFDE 320
TDT+ D K +N+ + K+A K+D K K +K T S ++ + +++ D
Sbjct: 370 TDTESGDAKDARNDSRNLKKASKNDDKKKDAKKITFSTDSESELESKESQKDEKKDKKDS 429
Query: 321 PLERVKN--NDPEMTEVNVNNSDCITNEILVRFTEALEFNTVVKLFALANTRADDHVAFA 378
+ K+ ND E T+ + +E + + K + + + D A
Sbjct: 430 KTDNKKSVKNDEESTDAD--------SEPKGDSKKGKKDEKKGKKDSKKDDKKKDAKKNA 481
Query: 379 IAIMLKANKTITSLNLDSNHI-TGKGILAIFRALLQNNTLTELRFHNQRHICGGKTEMEI 437
+ ++++ L D H KG + + +T + ++ G KT +I
Sbjct: 482 ESTEMESD---LELKKDKKHSKEKKGSKKDIKKDARKDTESTDAEFDESSKTGFKTSTKI 538
Query: 438 -AKLLKENTTLLKLGYHFELAGPRMTVTNLLSRNMDKQRQKRLQEQRQAQEAKGEKKDLL 496
+ +L K G ++ T N ++ +R R+ ++ KGEK
Sbjct: 539 KGSDTESEESLYKPGAKKKIDESDGTSANSKMEGLESKRGFRMSSKKTTFNEKGEKASTG 598
Query: 497 EVPKAGAVAKGSPKPSPQPSPKPSPKNSPKKGGAPAAPPPPPPPLAPPL 545
VP + + P P+ +PS PSPK ++ PPPPP P PL
Sbjct: 599 RVPPS---REKPPLPACEPS-LPSPK--VRRLCWCKMPPPPPKPRYAPL 641
Score = 42.4 bits (98), Expect = 0.001
Identities = 55/255 (21%), Positives = 100/255 (39%), Gaps = 37/255 (14%)
Query: 71 FCEKETKKLMQREMSMDESKQVETKTDAKN--GEERGRDASKKALGPR--RDSDLGKEPK 126
+ K K + + S DE K D+K G SK+ + + R ++ K P
Sbjct: 104 YTSKTHLKKAEYKKSKDEKGGTPLKKDSKKKGGSYATNPESKQIVEEKTKRQNEADKTP- 162
Query: 127 RGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATK 186
LK S ++ + S E E + + + K + DKK++ + + TK
Sbjct: 163 ---LKSSHENEQSKKSKSSSETNPESQNSKTVSKNCSQK--DKKDSKNSKKTNTEFLHTK 217
Query: 187 ---KEEEKKGSDRNTGLSR--DKDKKREEMKEVAKKEDDEKVKGER--RN---------- 229
K++ K+ N +S ++ + + + DDE + + RN
Sbjct: 218 NNPKKDLKRSKTSNDPISEICSENSLNVDFLMLVGQSDDESINFDAWLRNYSQNNSKNYS 277
Query: 230 --------TDTRKEGEKMKRAGG--NTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHE 279
DT+K +K A + D KK+ +KVK+ D KKD +K ++
Sbjct: 278 LKYTKYTKKDTKKNAKKSSDAESEDSKDAKKDSKKVKKNVKKDDKKKDVKKDTESTDAES 337
Query: 280 KEAKDDSKTKTPEKQ 294
++KD+ K +K+
Sbjct: 338 GDSKDERKDTKKDKK 352
>gi|239747134 PREDICTED: hypothetical protein XP_002343921 [Homo
sapiens]
Length = 600
Score = 70.1 bits (170), Expect = 6e-12
Identities = 53/252 (21%), Positives = 118/252 (46%), Gaps = 20/252 (7%)
Query: 50 RQRNQTEKQSTGVYNREAMLNFCEKETKKLMQREMSMDESKQVETKTDAKNGEERGRDAS 109
R++ QTE+++ R ++ K+ RE D K+ E +TD + +R ++ +
Sbjct: 66 REKRQTERETDRKRERRREK---DRHRKRDRHRERQRDREKERERQTDRERDRQREKERN 122
Query: 110 KKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGEKPK--EEKIIRGIDKGRVRAAV 167
++ R+ + +E +RG RDR G + E+ + E++ R D+ R R
Sbjct: 123 RQK---ERERETEREGERG-------RDRQTDGQRERERQRDAEKERERQTDRERQRQTE 172
Query: 168 DKKEAGKD---GRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVK 224
++ ++ R E R ++E+E K DR++ R+++++RE E +K ++ +
Sbjct: 173 RNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETERKRQTDRER 232
Query: 225 GERRNT--DTRKEGEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEA 282
+R T + K+ E+ + + T+ KE E+ + + D ++ + + + + +
Sbjct: 233 DRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKERERQTDRKRQRRTE 292
Query: 283 KDDSKTKTPEKQ 294
+D + E+Q
Sbjct: 293 RDRETERKRERQ 304
Score = 68.9 bits (167), Expect = 1e-11
Identities = 50/258 (19%), Positives = 118/258 (45%), Gaps = 18/258 (6%)
Query: 73 EKETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGG--- 129
E++T + QR+ + K+ E + + + ER R K+ R S+ G+E +R
Sbjct: 160 ERQTDRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETE 219
Query: 130 ----LKKSFSRDRDEAGGKSGEKPK----EEKIIRGIDKGRVRAAVDKKEAGKDGRGEER 181
K+ R+RD E+ K E R ++ + R ++ +D R +ER
Sbjct: 220 TETERKRQTDRERDRQRKTEREREKQAERERASERETERDKERERERDRDRDRDRRQKER 279
Query: 182 AVAT-----KKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEG 236
T ++ E + ++R R+++++RE ++ ++ + E+ + +R T+ +E
Sbjct: 280 ERQTDRKRQRRTERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREK 339
Query: 237 EKMKRAGGNTDMKKEDEKV--KRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQ 294
E+ ++ T+M +E + + G + +++ E+ + + E+E ++ + + +K+
Sbjct: 340 ERERKRKRQTEMDRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKE 399
Query: 295 TPSGPTKPSEGPAKVEEE 312
K +G + E++
Sbjct: 400 RERQTEKDRDGQRETEKQ 417
Score = 61.6 bits (148), Expect = 2e-09
Identities = 51/202 (25%), Positives = 98/202 (48%), Gaps = 11/202 (5%)
Query: 116 RRDSDLGKEPKRGGL----KKSFSRDRDEAGGKSGEKPKEEKII-RGIDKGRVRAAVDKK 170
RR + P+R GL K + DR+ K E+ +E++ R D+ R R +K
Sbjct: 28 RRRPGSQESPRRRGLGQAHKDADGDDRERNRQKERERRREKRQTERETDRKRERRR-EKD 86
Query: 171 EAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNT 230
K R ER +KE E++ +DR R+K++ R++ +E ++ + E +G R T
Sbjct: 87 RHRKRDRHRERQRDREKERERQ-TDRERDRQREKERNRQKERE--RETEREGERGRDRQT 143
Query: 231 DTRKEGEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKT 290
D ++E E+ + A + + + E+ ++ N +K+ E+ K + E+E + + + KT
Sbjct: 144 DGQRERERQRDAEKERERQTDRERQRQTERN--RQKEREREKNRQERRERERQREKENKT 201
Query: 291 PEKQTPSGPTKPSEGPAKVEEE 312
++ + G + E + E E
Sbjct: 202 EDRHSERGRERERERETETETE 223
Score = 60.1 bits (144), Expect = 6e-09
Identities = 56/279 (20%), Positives = 121/279 (43%), Gaps = 42/279 (15%)
Query: 50 RQRNQTEKQSTGVYNREAMLNFCEKETKKLMQREMSMDESKQVETKTDAKNGEERGRDAS 109
R++N+ E++ RE K + +R + ++ ET+T+ K +R RD
Sbjct: 181 REKNRQERRE-----RERQREKENKTEDRHSERGRERERERETETETERKRQTDRERDRQ 235
Query: 110 KKALGPR-----------RDSDLGKEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGI 158
+K R R+++ KE +R ++ RDRD K E+ + K R
Sbjct: 236 RKTEREREKQAERERASERETERDKERER---ERDRDRDRDRRQ-KERERQTDRKRQRRT 291
Query: 159 DKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKRE--------- 209
++ R +++ ++ E ++ E ++ +R RD++K+RE
Sbjct: 292 ERDRETERKRERQRERERERERNRKRERERERERERERQRETERDREKERERKRKRQTEM 351
Query: 210 ----------EMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVKRGT 259
E + A++E + + + +R++ R+E E+ + + +++ EK + G
Sbjct: 352 DRERNRQTGREGRRQAERERERERERDRQSAREREERERDRDRDRQKERERQTEKDRDGQ 411
Query: 260 GNTDTKKDDEKVKKNEPLHEK---EAKDDSKTKTPEKQT 295
T+ +++ EK +++E E+ K + + E+QT
Sbjct: 412 RETEKQREREKDRESERGRERGREREKQKGRERDRERQT 450
Score = 53.9 bits (128), Expect = 4e-07
Identities = 48/213 (22%), Positives = 95/213 (44%), Gaps = 26/213 (12%)
Query: 108 ASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAV 167
A K A G R+ + KE +R K+ R+ D + EK + K R ++ R R
Sbjct: 45 AHKDADGDDRERNRQKERERRREKRQTERETDRKRERRREKDRHRKRDRHRERQRDREKE 104
Query: 168 DKKEAGKD---------GRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKE 218
+++ ++ R +ER T++E E+ G DR T R+++++R+ KE ++
Sbjct: 105 RERQTDRERDRQREKERNRQKERERETEREGER-GRDRQTDGQRERERQRDAEKERERQT 163
Query: 219 DDE----------KVKGERRNTDTRKEGEKMKRAGGNTDMK-----KEDEKVKRGTGNTD 263
D E K + +N R+E E+ + T+ + +E E+ + T+
Sbjct: 164 DRERQRQTERNRQKEREREKNRQERRERERQREKENKTEDRHSERGRERERERETETETE 223
Query: 264 TKKDDEKVKKNEPLHEKE-AKDDSKTKTPEKQT 295
K+ ++ + + E+E K + + E++T
Sbjct: 224 RKRQTDRERDRQRKTEREREKQAERERASERET 256
Score = 52.8 bits (125), Expect = 9e-07
Identities = 53/249 (21%), Positives = 114/249 (45%), Gaps = 28/249 (11%)
Query: 73 EKETKKL--MQREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGL 130
+KE ++ +R+ + ++ E K + + ER R+ ++K R+ + +E +R
Sbjct: 276 QKERERQTDRKRQRRTERDRETERKRERQRERERERERNRKR---ERERERERERER--- 329
Query: 131 KKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGE-ERAVATKKEE 189
++ RDR EK +E K R + R R ++ G++GR + ER ++E
Sbjct: 330 QRETERDR--------EKERERKRKRQTEMDRER----NRQTGREGRRQAERERERERER 377
Query: 190 EKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMK 249
+++ + RD+D+ R++ +E EK + +R T+ ++E EK + + +
Sbjct: 378 DRQSAREREERERDRDRDRQKERE----RQTEKDRDGQRETEKQREREKDRESERGRERG 433
Query: 250 KEDEKVKRGTGNTDTKKDDE--KVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEGPA 307
+E EK K + + + D + + +K L+ +++ + P+ PT+ +
Sbjct: 434 REREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSD-PNRPTRGIRWKS 492
Query: 308 KVEEEAAPS 316
E+ A S
Sbjct: 493 SPEDPKAAS 501
Score = 52.4 bits (124), Expect = 1e-06
Identities = 50/256 (19%), Positives = 106/256 (41%), Gaps = 14/256 (5%)
Query: 73 EKETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLKK 132
E+ K+ +RE + +Q ET+ D + ER R + + R+ G+E +R ++
Sbjct: 312 ERNRKRERERERERERERQRETERDREKERERKRKRQTE-MDRERNRQTGREGRRQAERE 370
Query: 133 SFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKK 192
R+R+ + + +EE R D+ R R +++ KD G+ ++ E+ +
Sbjct: 371 ---RERERERDRQSAREREE---RERDRDRDRQKERERQTEKDRDGQRETEKQREREKDR 424
Query: 193 GSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAG-GNTDMKKE 251
S+R R+++K++ ++ ++ D + + +R+T + R+G +D +
Sbjct: 425 ESERGRERGREREKQKGRERDRERQTDRQAGRQRKRSTLYVNPPPRTARSGVVQSDPNRP 484
Query: 252 DEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSK----TKTPEKQTPSGPTKPSEGPA 307
++ + D K + P + + + EK+ G + G
Sbjct: 485 TRGIRWKSSPEDPKAASTRFPWGRPAKASRGRVAGRRRWEPRLGEKRGQGGEGRRPSGGF 544
Query: 308 KVEE--EAAPSIFDEP 321
E APS+F P
Sbjct: 545 GTENPLSQAPSVFPGP 560
>gi|32483416 neurofilament, heavy polypeptide 200kDa [Homo sapiens]
Length = 1020
Score = 70.1 bits (170), Expect = 6e-12
Identities = 79/296 (26%), Positives = 124/296 (41%), Gaps = 32/296 (10%)
Query: 22 ETLSPEEMEELEKE--LDVVDPDGSVPVGLRQRNQTEKQSTGVYNREAMLNFCEK----E 75
E SPE+ + EK LDV P+ P R+ +K + +A E+ E
Sbjct: 743 EAKSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADK-----FPEKAKSPVKEEVKSPE 797
Query: 76 TKKLMQREMSMDESKQVETKTDAKNG-EERGRDASKKALGPRRDSDLGKEPKRGGLKKSF 134
K +E + K++ K + K+ +E + K P + ++ K P ++
Sbjct: 798 KAKSPLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKK 857
Query: 135 SRDRDEAGGKSGEKPK-EEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKG 193
++EA K KPK EEK ++K + KKE +D +++ +KE K
Sbjct: 858 DSKKEEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAED---KKKVPTPEKEAPAK- 913
Query: 194 SDRNTGLSRDKDKKREEMKEVAKKE-DDEKVKGERRNTDTRKEGEKMKRAGGNTDMKKED 252
+ +D K +E EVAKKE DD K K + K EK + A D K+E
Sbjct: 914 ------VEVKEDAKPKEKTEVAKKEPDDAKAK------EPSKPAEKKEAAPEKKDTKEEK 961
Query: 253 EKVKRGTGNTDTK-KDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEGPA 307
K T+ K K+D+K EP K K + + T +K + P K +E A
Sbjct: 962 AKKPEEKPKTEAKAKEDDKTLSKEPSKPKAEKAEKSSSTDQKDS-KPPEKATEDKA 1016
Score = 68.9 bits (167), Expect = 1e-11
Identities = 85/303 (28%), Positives = 131/303 (43%), Gaps = 30/303 (9%)
Query: 22 ETLSPEEMEELEKELDVVDPDGSVPVGLRQRNQTEKQSTGVYNREAMLNFCEKETKKLMQ 81
E SPE+ + KE PV ++ +T +++ EA E K +
Sbjct: 701 EAKSPEKAKSPVKEEAKSPEKAKSPV--KEEAKTPEKAKSPVKEEAK----SPEKAKSPE 754
Query: 82 REMSMDESKQVETKTDAKNGEERGRDASK---KALGPRRDSDLGKEPKRGGLKKSFSRDR 138
+ ++D K E KT AK EE A K KA P ++ E + LK
Sbjct: 755 KAKTLDV-KSPEAKTPAK--EEARSPADKFPEKAKSPVKEEVKSPEKAKSPLK------- 804
Query: 139 DEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNT 198
++A E PK+E++ + + V KE K EE+A AT K EEKK S +
Sbjct: 805 EDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAE-EEKAPATPKTEEKKDSKKEE 863
Query: 199 GLSRDKDK-KREEMKEVA-KKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVK 256
++ K K EE KE A +K + KV+ ++ + +K+ ++ KED K K
Sbjct: 864 APKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAKPK 923
Query: 257 RGTGNTDTKKDDEKVKK-NEPLHEKEA----KD--DSKTKTPEKQTPSGPTKPSEGPAKV 309
T + DD K K+ ++P +KEA KD + K K PE++ P K E +
Sbjct: 924 EKTEVAKKEPDDAKAKEPSKPAEKKEAAPEKKDTKEEKAKKPEEK-PKTEAKAKEDDKTL 982
Query: 310 EEE 312
+E
Sbjct: 983 SKE 985
Score = 65.9 bits (159), Expect = 1e-10
Identities = 85/359 (23%), Positives = 134/359 (37%), Gaps = 43/359 (11%)
Query: 22 ETLSPEEMEELEKELDVVDPDGSVPVGLRQRNQTEKQSTGVYNREAMLNFCEKE-TKKLM 80
E SP E++ EK + P + + E +S E K +
Sbjct: 625 EAKSPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPV 684
Query: 81 QREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDE 140
+ E E + K +AK+ E+ ++A P + KE + +K+ S ++E
Sbjct: 685 KAEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKSPEKAKSPVKEEAKTP-EKAKSPVKEE 743
Query: 141 AGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGE--ERAVATKKEEEKKGSDRNT 198
A KS EK K + + +D A KE + + E+A + KEE K +
Sbjct: 744 A--KSPEKAKSPEKAKTLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKS 801
Query: 199 GLSRDKDK------KREEMK---------------EVAKKEDDEKV----KGERRNTDTR 233
L D K+EE+K E KK ++EK K E + +
Sbjct: 802 PLKEDAKAPEKEIPKKEEVKSPVKEEEKPQEVKVKEPPKKAEEEKAPATPKTEEKKDSKK 861
Query: 234 KEGEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEA----------K 283
+E K + + KKE K + KK++ + KK P EKEA K
Sbjct: 862 EEAPKKEAPKPKVEEKKEPAVEKPKESKVEAKKEEAEDKKKVPTPEKEAPAKVEVKEDAK 921
Query: 284 DDSKTKTPEKQTPSGPTKPSEGPAKVEEEAAPSIFDEPLERVKN-NDPEMTEVNVNNSD 341
KT+ +K+ K PA+ ++EAAP D E+ K + TE D
Sbjct: 922 PKEKTEVAKKEPDDAKAKEPSKPAE-KKEAAPEKKDTKEEKAKKPEEKPKTEAKAKEDD 979
Score = 52.8 bits (125), Expect = 9e-07
Identities = 73/325 (22%), Positives = 116/325 (35%), Gaps = 39/325 (12%)
Query: 22 ETLSPEEMEELEKELDVVDPDGSVPVGLRQRNQTEKQSTGVYNREAMLNFCEKETKKLMQ 81
E SP E++ EK + P + + E +S KE K
Sbjct: 537 EAKSPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPA 596
Query: 82 REMSMDESKQVETKTDAKNGEERGRDASKKALGPR--RDSDLGKEPKRGGLK---KSFSR 136
S +++K K +AK+ E ++A P + + K P + K K+ S
Sbjct: 597 EAKSPEKAKS-PVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKAKSP 655
Query: 137 DRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDR 196
+++EA KS EK K ++ K +A K + + E+A + KEE K
Sbjct: 656 EKEEA--KSPEKAKSP--VKAEAKSPEKA---KSPVKAEAKSPEKAKSPVKEEAKS---- 704
Query: 197 NTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVK 256
+K + +KE AK + K + K +K + + K EK K
Sbjct: 705 -------PEKAKSPVKEEAKSPEKAKSPVKEEAKTPEKAKSPVKEEAKSPEKAKSPEKAK 757
Query: 257 RGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTK-----------PSEG 305
D K + K E K K K+P K+ P K P +
Sbjct: 758 ----TLDVKSPEAKTPAKEEARSPADKFPEKAKSPVKEEVKSPEKAKSPLKEDAKAPEKE 813
Query: 306 PAKVEEEAAPSIFDEPLERVKNNDP 330
K EE +P +E + VK +P
Sbjct: 814 IPKKEEVKSPVKEEEKPQEVKVKEP 838
Score = 45.8 bits (107), Expect = 1e-04
Identities = 49/193 (25%), Positives = 83/193 (43%), Gaps = 15/193 (7%)
Query: 147 EKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDK 206
E+ +E ++ + + + A K+E GK+ G E A EEE K S +K+
Sbjct: 459 EQTEETQVTEEVTEEEEKEA--KEEEGKEEEGGEEEEAEGGEEETKSPPAEEAASPEKEA 516
Query: 207 K---REEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVKRGTGNTD 263
K +EE K A+ + EK E ++ K EK K + + K E
Sbjct: 517 KSPVKEEAKSPAEAKSPEKE--EAKSPAEVKSPEKAK-SPAKEEAKSPPEAKSPEKEEAK 573
Query: 264 TKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTK-----PSEGPAKVEEEAAPSIF 318
+ + + +K + ++EAK ++ K+PEK P K P+E + V+EEA
Sbjct: 574 SPAEVKSPEKAKSPAKEEAKSPAEAKSPEK--AKSPVKEEAKSPAEAKSPVKEEAKSPAE 631
Query: 319 DEPLERVKNNDPE 331
+ E+ K+ E
Sbjct: 632 VKSPEKAKSPTKE 644
Score = 45.4 bits (106), Expect = 1e-04
Identities = 44/197 (22%), Positives = 84/197 (42%), Gaps = 13/197 (6%)
Query: 148 KPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKE-EEKKGSDRNTGLSRDKDK 206
K K E+ I+ ++K + +++ + EE +KE +E++G + G + +
Sbjct: 437 KVKSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEKEAKEEEGKEEEGGEEEEAEG 496
Query: 207 KREEMK-----EVAKKEDDEK--VKGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVKRGT 259
EE K E A E + K VK E ++ K EK + A ++K ++
Sbjct: 497 GEEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKSPEK-EEAKSPAEVKSPEKAKSPAK 555
Query: 260 GNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTK---PSEGPAKVEEEA-AP 315
+ + + +K E E K K K+P K+ P + P + + V+EEA +P
Sbjct: 556 EEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKAKSPVKEEAKSP 615
Query: 316 SIFDEPLERVKNNDPEM 332
+ P++ + E+
Sbjct: 616 AEAKSPVKEEAKSPAEV 632
Score = 43.1 bits (100), Expect = 7e-04
Identities = 61/275 (22%), Positives = 100/275 (36%), Gaps = 40/275 (14%)
Query: 74 KETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLKKS 133
K +K+ E S E+ VE +T+ E + +K + GKE + G
Sbjct: 439 KSEEKIKVVEKSEKETVIVEEQTEETQVTEEVTEEEEK----EAKEEEGKEEEGG----- 489
Query: 134 FSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKG 193
+ E G + + P E+ AA +KEA + E ++ A K EK+
Sbjct: 490 -EEEEAEGGEEETKSPPAEE-----------AASPEKEAKSPVKEEAKSPAEAKSPEKEE 537
Query: 194 SDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKKEDE 253
+ S + K E+ K AK+E + + + K ++K KE+
Sbjct: 538 AK-----SPAEVKSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEA 592
Query: 254 KVKRGTGNTDTKKDDEKVKKNEPLHEK-----EAKDDSKTKTPEK---------QTPSGP 299
K + + K K + P K EAK ++ K+PEK ++P
Sbjct: 593 KSPAEAKSPEKAKSPVKEEAKSPAEAKSPVKEEAKSPAEVKSPEKAKSPTKEEAKSPEKA 652
Query: 300 TKPSEGPAKVEEEAAPSIFDEPLERVKNNDPEMTE 334
P + AK E+A + E K P E
Sbjct: 653 KSPEKEEAKSPEKAKSPVKAEAKSPEKAKSPVKAE 687
Score = 34.3 bits (77), Expect = 0.34
Identities = 25/128 (19%), Positives = 50/128 (39%), Gaps = 3/128 (2%)
Query: 469 RNMDKQRQKRLQEQRQAQEAKGEKKDLLEVPKAGAVAKGSPKPSPQPSPKPSPKNSPKKG 528
++ +K + +E + EAK +K+ + P + + P+ + + P+ SP+K
Sbjct: 545 KSPEKAKSPAKEEAKSPPEAKSPEKEEAKSPAEVKSPEKAKSPAKEEAKSPAEAKSPEKA 604
Query: 529 GAPAAPPPPPPPLAPPLIMENLKNSLSPATQRKMGDKVLPAQEKNSRDQLLAAIRSSNLK 588
+P P A + E K SPA + P +E+ + + K
Sbjct: 605 KSPVKEEAKSPAEAKSPVKEEAK---SPAEVKSPEKAKSPTKEEAKSPEKAKSPEKEEAK 661
Query: 589 QLKKVEVP 596
+K + P
Sbjct: 662 SPEKAKSP 669
Score = 30.8 bits (68), Expect = 3.7
Identities = 27/100 (27%), Positives = 40/100 (40%), Gaps = 6/100 (6%)
Query: 473 KQRQKRLQEQRQAQEAKGEKKDLLEVPKAGAVAKGSPKPSPQPSPKPSPKNSPKKGGAPA 532
++ K + A K K + E K+ A AK P + + P+ SP+K +PA
Sbjct: 498 EEETKSPPAEEAASPEKEAKSPVKEEAKSPAEAKS---PEKEEAKSPAEVKSPEKAKSPA 554
Query: 533 APPPPPPPLAPPLIMENLKNSLSPATQRKMGDKVLPAQEK 572
PP A E K SPA + PA+E+
Sbjct: 555 KEEAKSPPEAKSPEKEEAK---SPAEVKSPEKAKSPAKEE 591
>gi|239757964 PREDICTED: hypothetical protein [Homo sapiens]
Length = 290
Score = 69.3 bits (168), Expect = 9e-12
Identities = 52/218 (23%), Positives = 102/218 (46%), Gaps = 10/218 (4%)
Query: 88 ESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGE 147
E +V KT+ + +R RD ++ R++ + + R + RDR+ K E
Sbjct: 80 ERDRVREKTEKERDRDRKRDRERR----RKEKETNRNRDREK-QTEIERDREREKQKGRE 134
Query: 148 KPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKK 207
+ ++ R D+ R + + E +DG+ E + E +K +R T RD+D++
Sbjct: 135 RERDRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKERET--ERDRDRQ 192
Query: 208 REEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKD 267
R+ KE ++ D E+ + +R T T ++ E + TD ++E ++ + D ++D
Sbjct: 193 RDTEKERERQTDRERDR--QRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERD 250
Query: 268 DEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEG 305
++ +K E E++ K+ + K EK+ K EG
Sbjct: 251 RKEERKKERKKERK-KERKEKKKEEKRREDKKRKWGEG 287
Score = 67.4 bits (163), Expect = 4e-11
Identities = 63/247 (25%), Positives = 117/247 (47%), Gaps = 39/247 (15%)
Query: 50 RQRNQTEKQSTGVYNREAMLNFCEKETKKLMQREMSMDESKQVETKTDAKNGEERGRDAS 109
R R +TEK+ R+ EKET + RE KQ E + D + +++GR+
Sbjct: 83 RVREKTEKERDRDRKRDRERRRKEKETNRNRDRE------KQTEIERDREREKQKGRE-- 134
Query: 110 KKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDK 169
R+ D G+E +R RDR++ + EK ++ + ++ R R +
Sbjct: 135 -------RERDRGRERER-------DRDREKERERQTEKDRDGQRETETERERDREREKQ 180
Query: 170 KEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRN 229
KE + R +R T+KE E++ R++D++R+ E ++ D E GE R
Sbjct: 181 KERETE-RDRDRQRDTEKERERQ-------TDRERDRQRKTQTERQRETDRE---GE-RE 228
Query: 230 TDTRKEGEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTK 289
TD R+E ++ + G D +++ ++ ++ + KK+ ++ KK E++ ++D K K
Sbjct: 229 TDRRRERQRDRDRGKERDRERDRKEERKKERKKERKKERKEKKK-----EEKRREDKKRK 283
Query: 290 TPEKQTP 296
E +P
Sbjct: 284 WGEGISP 290
Score = 63.2 bits (152), Expect = 7e-10
Identities = 43/200 (21%), Positives = 94/200 (47%), Gaps = 10/200 (5%)
Query: 103 ERGRDASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGR 162
+R RD ++ RD D ++ +R +K +R+RD E+ +E + +G ++ R
Sbjct: 78 QRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREKQKGRERER 137
Query: 163 VRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEK 222
R +++ ++ E + + + + ++R R+K K+RE ++ ++ D EK
Sbjct: 138 DRGRERERDRDREKERERQTEKDRDGQRETETERERDREREKQKERETERDRDRQRDTEK 197
Query: 223 --------VKGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKN 274
+ +R T T ++ E + TD ++E ++ + D ++D ++ +K
Sbjct: 198 ERERQTDRERDRQRKTQTERQRETDREGERETDRRRERQRDRDRGKERDRERDRKEERKK 257
Query: 275 EPLHEKEAKDDSKTKTPEKQ 294
E +KE K + K K E++
Sbjct: 258 E--RKKERKKERKEKKKEEK 275
Score = 50.8 bits (120), Expect = 3e-06
Identities = 35/150 (23%), Positives = 70/150 (46%), Gaps = 10/150 (6%)
Query: 170 KEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKK-------REEMKEVAKKEDDEK 222
K+A D R ER +K E+++ DR R + +K RE+ E+ + + EK
Sbjct: 70 KDADGDDRQRERDRVREKTEKERDRDRKRDRERRRKEKETNRNRDREKQTEIERDREREK 129
Query: 223 VKGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEA 282
KG R D +E E+ + + +++ EK + G T+T+++ ++ ++ + E E
Sbjct: 130 QKGRERERDRGRERERDR--DREKERERQTEKDRDGQRETETERERDREREKQKERETE- 186
Query: 283 KDDSKTKTPEKQTPSGPTKPSEGPAKVEEE 312
+D + + EK+ + + K + E
Sbjct: 187 RDRDRQRDTEKERERQTDRERDRQRKTQTE 216
>gi|116089325 splicing factor, arginine/serine-rich 12 isoform a
[Homo sapiens]
Length = 624
Score = 65.9 bits (159), Expect = 1e-10
Identities = 54/223 (24%), Positives = 104/223 (46%), Gaps = 16/223 (7%)
Query: 74 KETKKLMQR--EMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLK 131
KE +++M+R E S +E ++ N + GR S R S KR
Sbjct: 273 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKR---- 328
Query: 132 KSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKD-GRGEERAVATKKEEE 190
S S+ R + +S + K+ + + K R ++ +K + R + + K +E+
Sbjct: 329 -SQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEK 387
Query: 191 KKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKK 250
++ +++ R+++K+RE+ KE K +D +K + + R D K+ E+ + D K
Sbjct: 388 ERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDK 447
Query: 251 EDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEK 293
E EK + D +K+ EK + E +++ K D K++TP +
Sbjct: 448 EKEKEQ------DKEKEREKDRSKEI--DEKRKKDKKSRTPPR 482
Score = 56.6 bits (135), Expect = 6e-08
Identities = 62/308 (20%), Positives = 129/308 (41%), Gaps = 46/308 (14%)
Query: 50 RQRNQTEKQSTGVYNREAMLNFCEKETKKLMQREMSMDESKQVETKTDAKNGE---ERGR 106
R R + ++S + + + K + R+ D ++++ K K + ER R
Sbjct: 342 RSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKERER 401
Query: 107 DASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAA 166
+ ++ KE +RG ++DRD+ K EK KE+ D+ R R
Sbjct: 402 EKERE-----------KEKERGK-----NKDRDKEREKDREKDKEK------DREREREK 439
Query: 167 VDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGE 226
+K+ K+ K++E+ K +R S++ D+KR+ K+ +
Sbjct: 440 EHEKDRDKE----------KEKEQDKEKEREKDRSKEIDEKRK--KDKKSRTPPRSYNAS 487
Query: 227 RRNTDTRKEGEKMKRAGGNTDMKKEDEKVKRGTGNTDT-----KKDDEKVKKNEPLHEKE 281
RR+ + +E + +R+ ++ + + +KR + + + KKD ++ K+ + + E+
Sbjct: 488 RRSRSSSRE-RRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERR 546
Query: 282 AKDDSKTKTPEKQTPSGPTKPSEGPAKVEEEAAPSIFDEPLER-VKNNDPEMTEVN--VN 338
++ S + G K + ++E+ D + + V + D TE N +
Sbjct: 547 ERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQH 606
Query: 339 NSDCITNE 346
N +C NE
Sbjct: 607 NGNCQLNE 614
>gi|21040255 splicing factor, arginine/serine-rich 12 isoform b
[Homo sapiens]
Length = 508
Score = 65.9 bits (159), Expect = 1e-10
Identities = 54/223 (24%), Positives = 104/223 (46%), Gaps = 16/223 (7%)
Query: 74 KETKKLMQR--EMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLK 131
KE +++M+R E S +E ++ N + GR S R S KR
Sbjct: 157 KELEEVMKRVREAQSFISAAIEPESGKSNERKGGRSRSHTRSKSRSSSKSHSRRKR---- 212
Query: 132 KSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKD-GRGEERAVATKKEEE 190
S S+ R + +S + K+ + + K R ++ +K + R + + K +E+
Sbjct: 213 -SQSKHRSRSHNRSRSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEK 271
Query: 191 KKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKK 250
++ +++ R+++K+RE+ KE K +D +K + + R D K+ E+ + D K
Sbjct: 272 ERVKEKDREKEREREKEREKEKERGKNKDRDKEREKDREKDKEKDREREREKEHEKDRDK 331
Query: 251 EDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEK 293
E EK + D +K+ EK + E +++ K D K++TP +
Sbjct: 332 EKEKEQ------DKEKEREKDRSKEI--DEKRKKDKKSRTPPR 366
Score = 56.6 bits (135), Expect = 6e-08
Identities = 62/308 (20%), Positives = 129/308 (41%), Gaps = 46/308 (14%)
Query: 50 RQRNQTEKQSTGVYNREAMLNFCEKETKKLMQREMSMDESKQVETKTDAKNGE---ERGR 106
R R + ++S + + + K + R+ D ++++ K K + ER R
Sbjct: 226 RSRQKDRRRSKSPHKKRSKSRERRKSRSRSHSRDKRKDTREKIKEKERVKEKDREKERER 285
Query: 107 DASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAA 166
+ ++ KE +RG ++DRD+ K EK KE+ D+ R R
Sbjct: 286 EKERE-----------KEKERGK-----NKDRDKEREKDREKDKEK------DREREREK 323
Query: 167 VDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGE 226
+K+ K+ K++E+ K +R S++ D+KR+ K+ +
Sbjct: 324 EHEKDRDKE----------KEKEQDKEKEREKDRSKEIDEKRK--KDKKSRTPPRSYNAS 371
Query: 227 RRNTDTRKEGEKMKRAGGNTDMKKEDEKVKRGTGNTDT-----KKDDEKVKKNEPLHEKE 281
RR+ + +E + +R+ ++ + + +KR + + + KKD ++ K+ + + E+
Sbjct: 372 RRSRSSSRE-RRRRRSRSSSRSPRTSKTIKRKSSRSPSPRSRNKKDKKREKERDHISERR 430
Query: 282 AKDDSKTKTPEKQTPSGPTKPSEGPAKVEEEAAPSIFDEPLER-VKNNDPEMTEVN--VN 338
++ S + G K + ++E+ D + + V + D TE N +
Sbjct: 431 ERERSTSMRKSSNDRDGKEKLEKNSTSLKEKEHNKEPDSSVSKEVDDKDAPRTEENKIQH 490
Query: 339 NSDCITNE 346
N +C NE
Sbjct: 491 NGNCQLNE 498
>gi|13540523 nucleosomal binding protein 1 [Homo sapiens]
Length = 282
Score = 64.7 bits (156), Expect = 2e-10
Identities = 68/253 (26%), Positives = 115/253 (45%), Gaps = 54/253 (21%)
Query: 75 ETKKLMQREMSMDESKQVETKT------------DAKNGEERGRDA--SKKALGPRRDSD 120
+TK M E ++D S Q +T +AKNGE + +A S+K + ++ +
Sbjct: 46 KTKSDMMEE-NIDTSAQAVAETKQEAVVEEDYNENAKNGEAKITEAPASEKEIVEVKEEN 104
Query: 121 LGKEPKRGGLKKSF------------SRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVD 168
+ ++GG KK D ++ + GE KE+K +G + G
Sbjct: 105 IEDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDG------- 157
Query: 169 KKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGE-R 227
K++ + +GE+ A +KE+ KKG D G D +K E+ KE E+D K G+ +
Sbjct: 158 KEDKNGNEKGED---AKEKEDGKKGED-GKGNGEDGKEKGEDEKE----EEDRKETGDGK 209
Query: 228 RNTDTRKEGEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKE------ 281
N D +++G+K + G KEDEK + + ++E K+ E L E+E
Sbjct: 210 ENEDGKEKGDKKE---GKDVKVKEDEKEREDGKEDEGGNEEEAGKEKEDLKEEEEGKEED 266
Query: 282 --AKDDSKTKTPE 292
+DD K + P+
Sbjct: 267 EIKEDDGKKEEPQ 279
Score = 51.2 bits (121), Expect = 3e-06
Identities = 53/203 (26%), Positives = 86/203 (42%), Gaps = 38/203 (18%)
Query: 47 VGLRQRNQTEKQSTGVYNREAMLNFCEKETKKLMQREMSMDESKQVETKTDA-------- 98
V +++ N + G +EA+ + E + + E +E K K D
Sbjct: 98 VEVKEENIEDATEKGGEKKEAVAAEVKNEEEDQKEDEEDQNEEKGEAGKEDKDEKGEEDG 157
Query: 99 ---KNGEERGRDASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKII 155
KNG E+G DA +K D G++ K G E G + GE KEE+
Sbjct: 158 KEDKNGNEKGEDAKEK-----EDGKKGEDGKGNG----------EDGKEKGEDEKEEEDR 202
Query: 156 RGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKK---GSDRNTGLSRDKDKKREEMK 212
+ G+ D KE G G++ V KE+EK+ G + G + K++E++K
Sbjct: 203 KETGDGKENE--DGKEKGDKKEGKDVKV---KEDEKEREDGKEDEGGNEEEAGKEKEDLK 257
Query: 213 EVAKKEDDEKVKGERRNTDTRKE 235
E E++ K + E + D +KE
Sbjct: 258 E----EEEGKEEDEIKEDDGKKE 276
Score = 47.8 bits (112), Expect = 3e-05
Identities = 74/278 (26%), Positives = 107/278 (38%), Gaps = 64/278 (23%)
Query: 110 KKALGPRRDSDLGKEPKRGGLKKS---------FSRDRDEAGGKSGEKPKEEKIIRGIDK 160
+KA G D+ +EPKR + S R + K K K + + ID
Sbjct: 4 RKAAG---QGDMRQEPKRRSARLSAMLVPVTPEVKPKRTSSSRKM--KTKSDMMEENIDT 58
Query: 161 GRVRAAVDKKEA---------GKDGRGE-------ERAVATKKEEE-----KKGSDRNTG 199
A K+EA K+G + E+ + KEE +KG ++
Sbjct: 59 SAQAVAETKQEAVVEEDYNENAKNGEAKITEAPASEKEIVEVKEENIEDATEKGGEKKEA 118
Query: 200 LSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVKR-- 257
++ + + E+ KE +ED + KGE D ++GE+ + N + K ED K K
Sbjct: 119 VAAEVKNEEEDQKE--DEEDQNEEKGEAGKEDKDEKGEEDGKEDKNGNEKGEDAKEKEDG 176
Query: 258 -----GTGNTD---TKKDDEKV----------KKNEPLHEKEAK---DDSKTKTPEKQTP 296
G GN + K +DEK K+NE EK K D K K EK+
Sbjct: 177 KKGEDGKGNGEDGKEKGEDEKEEEDRKETGDGKENEDGKEKGDKKEGKDVKVKEDEKERE 236
Query: 297 SGPTKPSEGPAKVEEEAAPSIFDEPLERVKNNDPEMTE 334
G K EG EEEA D E + E+ E
Sbjct: 237 DG--KEDEGGN--EEEAGKEKEDLKEEEEGKEEDEIKE 270
>gi|41327773 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46 [Homo
sapiens]
Length = 1031
Score = 64.3 bits (155), Expect = 3e-10
Identities = 56/221 (25%), Positives = 98/221 (44%), Gaps = 9/221 (4%)
Query: 93 ETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGEKPKEE 152
E++ K RGR S+ R S K KRG ++S SRDRD +S + K
Sbjct: 4 ESRHYRKRSASRGRSGSRS----RSRSPSDKRSKRGDDRRSRSRDRDRRRERSRSRDKRR 59
Query: 153 KIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSR-DKDKKREEM 211
R D+ R+R + ++ R R+ ++ + R+ S +K KK E
Sbjct: 60 S--RSRDRKRLRRSRSRERDRSRERRRSRSRDRRRSRSRSRGRRSRSSSPGNKSKKTENR 117
Query: 212 KEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKV 271
+K D + E++ KE EK K AG N D K +E++++ + +++++
Sbjct: 118 SRSKEKTDGGESSKEKKKDKDDKEDEKEKDAG-NFDQNKLEEEMRKRKERVEKWREEQRK 176
Query: 272 KKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEGPAKVEEE 312
K E + E + K+ + K +K + + PA+ E+E
Sbjct: 177 KAMENIGELK-KEIEEMKQGKKWSLEDDDDDEDDPAEAEKE 216
Score = 51.6 bits (122), Expect = 2e-06
Identities = 61/290 (21%), Positives = 120/290 (41%), Gaps = 42/290 (14%)
Query: 81 QREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDE 140
+R S D ++ E R RD + R+ D +E +R SR RD
Sbjct: 38 RRSRSRDRDRRRERSRSRDKRRSRSRDRKRLRRSRSRERDRSRERRR-------SRSRDR 90
Query: 141 AGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGL 200
+S + R R + K + E R ++ +E+ G + +
Sbjct: 91 RRSRS--------------RSRGRRSRSSSPGNKSKKTENR---SRSKEKTDGGESSKEK 133
Query: 201 SRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKE---GEKMKRAGGNT-DMKKEDEKVK 256
+DKD K +E ++ A D K++ E R R E E+ K+A N ++KKE E++K
Sbjct: 134 KKDKDDKEDEKEKDAGNFDQNKLEEEMRKRKERVEKWREEQRKKAMENIGELKKEIEEMK 193
Query: 257 RG---TGNTDTKKDDEKVKKNEPLHEKEAKD----DSKTKTPEKQTPSGPTKPSEGPAKV 309
+G + D +D+ + + +E E ++ D+ + +++ + +G
Sbjct: 194 QGKKWSLEDDDDDEDDPAEAEKEGNEMEGEELDPLDAYMEEVKEEVKKFNMRSVKGGGGN 253
Query: 310 EEEAAPSIFDEPLERVKNNDPEMTEVNVNNSDCITNEILVRFTEALEFNT 359
E+++ P++ K T+ V +SD E++ +A+E+++
Sbjct: 254 EKKSGPTV-------TKVVTVVTTKKAVVDSDKKKGELMENDQDAMEYSS 296
Score = 41.6 bits (96), Expect = 0.002
Identities = 36/162 (22%), Positives = 62/162 (38%), Gaps = 14/162 (8%)
Query: 161 GRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDD 220
GR K+ A + G + ++ K D SRD+D++RE + K+
Sbjct: 2 GRESRHYRKRSASRGRSGSRSRSRSPSDKRSKRGDDRRSRSRDRDRRRERSRSRDKRRSR 61
Query: 221 EKVKGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVKRG-------TGNTDTKKDD---EK 270
+ + R + +R+ +R + ++ RG GN K ++ K
Sbjct: 62 SRDRKRLRRSRSRERDRSRERRRSRSRDRRRSRSRSRGRRSRSSSPGNKSKKTENRSRSK 121
Query: 271 VKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEGPAKVEEE 312
K + KE K D K EK+ +G + K+EEE
Sbjct: 122 EKTDGGESSKEKKKDKDDKEDEKEKDAGNFDQN----KLEEE 159
Score = 38.1 bits (87), Expect = 0.023
Identities = 44/206 (21%), Positives = 75/206 (36%), Gaps = 24/206 (11%)
Query: 129 GLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKE 188
G + R R + G+SG + R R+ DK+ RG++R ++
Sbjct: 2 GRESRHYRKRSASRGRSGSR------------SRSRSPSDKRSK----RGDDRRSRSRDR 45
Query: 189 EEKKGSDRNTGLSRDKDKKR-EEMKEVAKKEDDEKVKG-ERRNTDTRKEGEKMKRAGGNT 246
+ ++ R SRDK + R + K + + E+ + ERR + +R R+ G
Sbjct: 46 DRRRERSR----SRDKRRSRSRDRKRLRRSRSRERDRSRERRRSRSRDRRRSRSRSRGRR 101
Query: 247 DMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEGP 306
+ T N K EK E EK+ D K EK + E
Sbjct: 102 SRSSSPGNKSKKTENRSRSK--EKTDGGESSKEKKKDKDDKEDEKEKDAGNFDQNKLEEE 159
Query: 307 AKVEEEAAPSIFDEPLERVKNNDPEM 332
+ +E +E ++ N E+
Sbjct: 160 MRKRKERVEKWREEQRKKAMENIGEL 185
>gi|84043963 eukaryotic translation initiation factor 5B [Homo
sapiens]
Length = 1220
Score = 63.9 bits (154), Expect = 4e-10
Identities = 85/343 (24%), Positives = 144/343 (41%), Gaps = 33/343 (9%)
Query: 2 SRVAKYRRQVSEDPDIDSLLETLSPEEMEELEKELDVVDPDGSV----PVGLRQRNQTEK 57
S+ K + + +D D D +L+ E+EEL E + D P + T K
Sbjct: 40 SKGKKKKEKKKQDFDEDDILK-----ELEELSLEAQGIKADRETVAVKPTENNEEEFTSK 94
Query: 58 QSTGVYNREAMLNFCEKETKKLMQREMSMDESKQVETKTDAKNGEERGRDASK---KALG 114
+ +F + ++++L ++ K + K + +G + D +K KA G
Sbjct: 95 DKKKKGQKGKKQSFDDNDSEELEDKDSK--SKKTAKPKVEMYSGSDDDDDFNKLPKKAKG 152
Query: 115 PRRDSDL---GKEPKRGGLKKSFSRDRDEAGGKSGEKPKE----EKIIRGIDKGRVRAAV 167
+ S+ G E KK R R + G+SG++ E K + K + +
Sbjct: 153 KAQKSNKKWDGSEEDEDNSKKIKERSRINSSGESGDESDEFLQSRKGQKKNQKNKPGPNI 212
Query: 168 DKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDK-KREEMKEVAKKEDDEKVKGE 226
+ D + + VA KK E KK +R RD++K K ++KE + E +K + +
Sbjct: 213 ESGNEDDDASFKIKTVAQKKAE-KKERERK---KRDEEKAKLRKLKEKEELETGKKDQSK 268
Query: 227 RRNTDTRKEGE--KMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVK-KNEPLHEKEAK 283
++ + + E E K K + +EK + T D + D+K K K + EKE K
Sbjct: 269 QKESQRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEK 328
Query: 284 DDSKTKTPEKQTPSGPTKPSEGPAKVEEEAAPSIFDEPLERVK 326
+ K K P K T E AK++EE +E ER+K
Sbjct: 329 EKEKKKGPSKATVKA---MQEALAKLKEEEERQKREEE-ERIK 367
Score = 54.7 bits (130), Expect = 2e-07
Identities = 56/234 (23%), Positives = 108/234 (46%), Gaps = 30/234 (12%)
Query: 87 DESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSG 146
D+ + KT A+ E+ KK RD + K K ++ + +D++ K
Sbjct: 218 DDDASFKIKTVAQKKAEKKERERKK-----RDEEKAKLRKLKEKEELETGKKDQSKQKES 272
Query: 147 EKPKEEKIIRG---IDKGRVRAAVDKKE----AGKDGRGEERAVATKK---EEEKKGSDR 196
++ EE+ ++ +D G + A+ +K E A D G+++ KK E+E+K ++
Sbjct: 273 QRKFEEETVKSKVTVDTGVIPASEEKAETPTAAEDDNEGDKKKKDKKKKKGEKEEKEKEK 332
Query: 197 NTGLSRDKDK-------KREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMK 249
G S+ K K +E +E K+E++E++K RKE E++++ +
Sbjct: 333 KKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRKEEERLEQEKRERKKQ 392
Query: 250 KEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPS 303
KE E+ +R KK+ + + K++ E A+ ++ K + Q P+K S
Sbjct: 393 KEKERKER------LKKEGKLLTKSQ--REARARAEATLKLLQAQGVEVPSKDS 438
Score = 52.8 bits (125), Expect = 9e-07
Identities = 68/341 (19%), Positives = 136/341 (39%), Gaps = 43/341 (12%)
Query: 23 TLSPEEMEELEKELDVVDPDGSVPVGLRQRNQTEKQSTGVYNREAMLNFCEKETKKLMQR 82
T + ++ E +K+ D G +++ + ++T +EA+ E+E ++ +
Sbjct: 303 TAAEDDNEGDKKKKDKKKKKGEKEEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREE 362
Query: 83 EMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAG 142
E + +++E K + E+ + KK R L KE K + +R R EA
Sbjct: 363 EERIKRLEELEAKRKEEERLEQEKRERKKQKEKERKERLKKEGKLLTKSQREARARAEAT 422
Query: 143 GK-----------SGEKPKEEKIIRGIDKGRVRAAVDKKEAG------------KDGRGE 179
K PK+ I + ++ ++ KE + G E
Sbjct: 423 LKLLQAQGVEVPSKDSLPKKRPIYEDKKRKKIPQQLESKEVSESMELCAAVEVMEQGVPE 482
Query: 180 ERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKM 239
+ E E++ + GL ++ + +A E+ EKV+G + + + ++ E+
Sbjct: 483 KEETPPPVEPEEEEDTEDAGL--------DDWEAMASDEETEKVEGNKVHIEVKENPEEE 534
Query: 240 KRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKT--KTPEKQTPS 297
+ + +E E+ + G ++ + DE+ +K + KD KT K P K+ S
Sbjct: 535 EEEEEEEEEDEESEEEEEEEGESEGSEGDEEDEK-----VSDEKDSGKTLDKKPSKEMSS 589
Query: 298 GPTKPSEGPAKVEEEAAPSIFDEPLERVKNNDPEMTEVNVN 338
S+ EE A +D+ R++ E ++ NVN
Sbjct: 590 DSEYDSDDDRTKEERA----YDKAKRRIEKRRLEHSK-NVN 625
Score = 50.8 bits (120), Expect = 3e-06
Identities = 64/267 (23%), Positives = 118/267 (44%), Gaps = 44/267 (16%)
Query: 73 EKETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLKK 132
+K KK E D SK+++ ++ + E G D S + L R+ ++ K G +
Sbjct: 155 QKSNKKWDGSEEDEDNSKKIKERSRINSSGESG-DESDEFLQSRKGQKKNQKNKPGPNIE 213
Query: 133 SFSRDRDEA------GGKSGEKPKEEKIIRGIDKGRVRAAVDKKE--AGKDGRGEERAVA 184
S + D D + K EK + E+ R +K ++R +K+E GK + +++
Sbjct: 214 SGNEDDDASFKIKTVAQKKAEKKERERKKRDEEKAKLRKLKEKEELETGKKDQSKQKESQ 273
Query: 185 TKKEEE--KKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKE-GEKMKR 241
K EEE K +TG+ ++K E A ++D+E G+++ D +K+ GEK
Sbjct: 274 RKFEEETVKSKVTVDTGVIPASEEKAET--PTAAEDDNE---GDKKKKDKKKKKGEK--- 325
Query: 242 AGGNTDMKKEDEKVKRGTGNTDT-----------KKDDEKVKKNEP-----LHEKEAKDD 285
+E EK K+ + T K+++E+ K+ E L E EAK
Sbjct: 326 --------EEKEKEKKKGPSKATVKAMQEALAKLKEEEERQKREEEERIKRLEELEAKRK 377
Query: 286 SKTKTPEKQTPSGPTKPSEGPAKVEEE 312
+ + +++ K E ++++E
Sbjct: 378 EEERLEQEKRERKKQKEKERKERLKKE 404
Score = 37.4 bits (85), Expect = 0.040
Identities = 27/121 (22%), Positives = 53/121 (43%), Gaps = 6/121 (4%)
Query: 147 EKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDK 206
E P+EE+ ++ ++ E ++ GE +E+EK ++++G + DK
Sbjct: 529 ENPEEEE-----EEEEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKP 583
Query: 207 KREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMK-RAGGNTDMKKEDEKVKRGTGNTDTK 265
+E + DD++ K ER ++ EK + N + +K + G+ DT
Sbjct: 584 SKEMSSDSEYDSDDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEKLRAPIICVLGHVDTG 643
Query: 266 K 266
K
Sbjct: 644 K 644
Score = 33.9 bits (76), Expect = 0.44
Identities = 31/120 (25%), Positives = 51/120 (42%), Gaps = 9/120 (7%)
Query: 184 ATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDD-----EKVKGERRNTDTRKEGEK 238
A E E G+ + + K KK++E K+ EDD E++ E + +E
Sbjct: 21 ALAAEIEGAGAAKEQEPQKSKGKKKKEKKKQDFDEDDILKELEELSLEAQGIKADRETVA 80
Query: 239 MKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSG 298
+K N + +K K+G DD +E L +K++K KT P+ + SG
Sbjct: 81 VKPTENNEEEFTSKDKKKKGQKGKKQSFDD---NDSEELEDKDSK-SKKTAKPKVEMYSG 136
Score = 32.7 bits (73), Expect = 0.98
Identities = 35/153 (22%), Positives = 63/153 (41%), Gaps = 22/153 (14%)
Query: 148 KPKEEKIIR--GIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKD 205
+P+EE+ G+D A+ ++ E + + +EEE++
Sbjct: 491 EPEEEEDTEDAGLDDWEAMASDEETEKVEGNKVHIEVKENPEEEEEE------------- 537
Query: 206 KKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKM---KRAGGNTDMK--KEDEKVKRGTG 260
EE +E + E++E+ +GE ++ +E EK+ K +G D K KE
Sbjct: 538 --EEEEEEDEESEEEEEEEGESEGSEGDEEDEKVSDEKDSGKTLDKKPSKEMSSDSEYDS 595
Query: 261 NTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEK 293
+ D K++ K + EK + SK EK
Sbjct: 596 DDDRTKEERAYDKAKRRIEKRRLEHSKNVNTEK 628
Score = 31.2 bits (69), Expect = 2.8
Identities = 28/119 (23%), Positives = 46/119 (38%), Gaps = 7/119 (5%)
Query: 186 KKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGN 245
KK++ K + D E AK+++ +K KG +K+ EK K+
Sbjct: 3 KKQKNKSEDSTKDDIDLDALAAEIEGAGAAKEQEPQKSKG-------KKKKEKKKQDFDE 55
Query: 246 TDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSE 304
D+ KE E++ ++ VK E E+ D K K + + S SE
Sbjct: 56 DDILKELEELSLEAQGIKADRETVAVKPTENNEEEFTSKDKKKKGQKGKKQSFDDNDSE 114
>gi|78190492 retinitis pigmentosa GTPase regulator isoform C [Homo
sapiens]
Length = 1152
Score = 62.0 bits (149), Expect = 2e-09
Identities = 71/318 (22%), Positives = 135/318 (42%), Gaps = 38/318 (11%)
Query: 21 LETLSPEEMEELEKELDVVDPDGSVPVGLRQRNQTEKQSTGVYNREAMLNFCEKETKKLM 80
+E S EE+E E++ D G N E+Q ++ KE +++
Sbjct: 576 IEAFSDEEVEIPEEKEGAEDSKG---------NGIEEQEVEANEENVKVHGGRKEKTEIL 626
Query: 81 ------QREMSMDESKQVETKTDAKNGE-----ERGRDASKKALGPRRDS---DLGK-EP 125
+ E+S ++K V D G E G ++ R+ D G+ E
Sbjct: 627 SDDLTDKAEVSEGKAKSVGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKGEKDKGRGEM 686
Query: 126 KRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKD--GRGEERAV 183
+R G + +++E + GE+ ++++ +G K R + + +E G++ G GEE
Sbjct: 687 ERPGEGEKELAEKEEWKKRDGEEQEQKEREQGHQKERNQ---EMEEGGEEEHGEGEEEEG 743
Query: 184 ATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKED---------DEKVKGERRNTDTRK 234
++EEEK+G + G + + +RE+ + KKE+ +E +GE +T
Sbjct: 744 DREEEEEKEGEGKEEGEGEEVEGEREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEG 803
Query: 235 EGEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQ 294
GE+ + G + E+ K +R + + ++E+ + E E E ++ E +
Sbjct: 804 RGEEKEEGGEVEGGEVEEGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGE 863
Query: 295 TPSGPTKPSEGPAKVEEE 312
G + EG + EEE
Sbjct: 864 EGEGEEEGEEGEGEGEEE 881
Score = 57.8 bits (138), Expect = 3e-08
Identities = 54/246 (21%), Positives = 101/246 (41%), Gaps = 10/246 (4%)
Query: 93 ETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGEKPKEE 152
E K + + EE G ++ G + + +E G ++ E G+ GE EE
Sbjct: 821 EGKGEREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEE 880
Query: 153 KIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMK 212
+ G +G + +E +G GEE +EEE +G G + + + EE +
Sbjct: 881 E--EGEGEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGE 938
Query: 213 EVAK--KEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEK 270
+ + + E+ +GE + EGE + G + + + + + G G + ++ +E
Sbjct: 939 GEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEE- 997
Query: 271 VKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEGPAKVEEEAAPSIFDEPLERVKNNDP 330
+ E E E + + + + E+ G + EG + EEE +E ER K +
Sbjct: 998 --EGEEEGEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGE---EEGEEREKEGEG 1052
Query: 331 EMTEVN 336
E N
Sbjct: 1053 EENRRN 1058
Score = 52.0 bits (123), Expect = 2e-06
Identities = 47/228 (20%), Positives = 95/228 (41%), Gaps = 5/228 (2%)
Query: 81 QREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSD-LGKEPKRGGLKKSFSRDRD 139
+RE +E + E + + + E G + + G + G+E G + + +
Sbjct: 825 EREEEEEEGEGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGE 884
Query: 140 EAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAV--ATKKEEEKKGSDRN 197
G + GE EE+ G +G + +E +G+GEE + EEE+ +
Sbjct: 885 GEGEEEGEGEGEEE--EGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGE 942
Query: 198 TGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVKR 257
G ++++ E E + E + + +GE + EGE+ + G + + E+E +
Sbjct: 943 DGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEGEGEGEEEEGEEEGEEE 1002
Query: 258 GTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEG 305
G G + + + E+ ++ E E E ++ E+ G + EG
Sbjct: 1003 GEGEEEGEGEGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEG 1050
Score = 51.6 bits (122), Expect = 2e-06
Identities = 67/305 (21%), Positives = 129/305 (42%), Gaps = 32/305 (10%)
Query: 28 EMEELEKELDVVDPDGSVPVGLRQRNQTEKQSTGVYNREAMLNFCEKETKKLMQREMSMD 87
E EE E E + + +G G + + ++ G E E+E + E
Sbjct: 834 EGEEEEGEGEEEEGEGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEGEGEEEGEG 893
Query: 88 ESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGE 147
E ++ E + + GEE G ++ G + + G+E + G ++ + ++ G+ E
Sbjct: 894 EGEEEEGEGE---GEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGEDGEGEGEE 950
Query: 148 KPKE----------EKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRN 197
+ E E G +G ++E G +G GEE + EEE +G +
Sbjct: 951 EEGEWEGEEEEGEGEGEEEGEGEGEEGEGEGEEEEG-EGEGEEEEGEEEGEEEGEGEEEG 1009
Query: 198 TGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGG------NTDMKKE 251
G + + EE EV + + E+ +GE + +EGE+ ++ G N + ++E
Sbjct: 1010 EG-----EGEEEEEGEVEGEVEGEEGEGEGEEEEGEEEGEEREKEGEGEENRRNREEEEE 1064
Query: 252 DEKVKRGTGNTDTKKDD-EKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEGPAKVE 310
+E + TG + ++ D E+ KK + K + K KT +K++ + ++G K +
Sbjct: 1065 EEGKYQETGEEENERQDGEEYKKVSKI--KGSVKYGKHKTYQKKSVTN----TQGNGKEQ 1118
Query: 311 EEAAP 315
P
Sbjct: 1119 RSKMP 1123
Score = 50.4 bits (119), Expect = 5e-06
Identities = 60/258 (23%), Positives = 105/258 (40%), Gaps = 29/258 (11%)
Query: 73 EKETKKLMQREMSMDESKQVE----TKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRG 128
E+E +R M+E + E + + EE ++ K G + + +E + G
Sbjct: 714 EREQGHQKERNQEMEEGGEEEHGEGEEEEGDREEEEEKEGEGKEEGEGEEVEGEREKEEG 773
Query: 129 GLKKSFSRDRDEAG---GKSGEKPKEEKIIRGIDK--------GRVRAAVDKKEAGKD-- 175
KK ++E G G GE +EE RG +K G V ++E ++
Sbjct: 774 ERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGEREEEEEEG 833
Query: 176 -GRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRK 234
G EE +EEE +G + + K EE +E +E+ E+ +GE +
Sbjct: 834 EGEEEE---GEGEEEEGEGEE-----EEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGEG 885
Query: 235 EGEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQ 294
EGE+ G ++E E G + ++++ + K E E E + + + E +
Sbjct: 886 EGEEEGEGEGE---EEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGEGEGEEEEGEGEGE 942
Query: 295 TPSGPTKPSEGPAKVEEE 312
G + EG + EEE
Sbjct: 943 DGEGEGEEEEGEWEGEEE 960
Score = 48.5 bits (114), Expect = 2e-05
Identities = 57/262 (21%), Positives = 114/262 (43%), Gaps = 21/262 (8%)
Query: 81 QREMSMDESKQVETKTDAKNGEE---RGRDASKKALGPRRDSDLGKEPKRGGLKKSFS-R 136
+RE E K+ E + GEE +G ++ G + + G E + G +++ R
Sbjct: 767 EREKEEGERKKEERAGKEEKGEEEGDQGEGEEEETEGRGEEKEEGGEVEGGEVEEGKGER 826
Query: 137 DRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDK-KEAGKDGRGEERAVATK---KEEEKK 192
+ +E G+ E+ E + G +G K +E G++G GEE + +EEE +
Sbjct: 827 EEEEEEGEGEEEEGEGEEEEG--EGEEEEGEGKGEEEGEEGEGEEEGEEGEGEGEEEEGE 884
Query: 193 GSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKKED 252
G G ++++ E E + + E+ +GE + + +EGE G + ++ +
Sbjct: 885 GEGEEEGEGEGEEEEGEGEGEEEGEGEGEEEEGEGKGEEEGEEGE------GEGEEEEGE 938
Query: 253 EKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEGPAKVEEE 312
+ + G G + ++ + + ++ E E E + + + + E G + EG + EEE
Sbjct: 939 GEGEDGEGEGEEEEGEWEGEEEEGEGEGEEEGEGEGEEGE-----GEGEEEEGEGEGEEE 993
Query: 313 AAPSIFDEPLERVKNNDPEMTE 334
+E E + + E E
Sbjct: 994 EGEEEGEEEGEGEEEGEGEGEE 1015
Score = 47.8 bits (112), Expect = 3e-05
Identities = 76/335 (22%), Positives = 140/335 (41%), Gaps = 60/335 (17%)
Query: 22 ETLSPEE----MEELEKELDVVDPDGSVPVGLRQR--NQTEKQSTGVYNREAMLNFCEKE 75
+ + PEE ++E+ KE ++ + +G N T S + L+ +K+
Sbjct: 464 DLMQPEEPDYLLDEMTKEAEIDNSSTVESLGETTDILNMTHIMSLNSNEKSLKLSPVQKQ 523
Query: 76 TKKLMQREMSMD-------ESKQVETKTDAKNGEERGRDASKKALGPRRDSDL------- 121
K+ E++ D +S + E ++ K G+ + S+ + + +
Sbjct: 524 KKQQTIGELTQDTALTENDDSDEYEEMSEMKEGKACKQHVSQGIFMTQPATTIEAFSDEE 583
Query: 122 --------GKEPKRGGLKKSFSRDRDEAGGK--SGEKPKEEKIIRGI-DKGRVRA----A 166
G E +G + + +E K G K K E + + DK V +
Sbjct: 584 VEIPEEKEGAEDSKGNGIEEQEVEANEENVKVHGGRKEKTEILSDDLTDKAEVSEGKAKS 643
Query: 167 VDKKEAGKDGRGEERAV-ATKKEEEKKGSDRNTGLSRDKDKKREEM-------KEVAKKE 218
V + E G +GRG+ + E + +R G +KDK R EM KE+A+KE
Sbjct: 644 VGEAEDGPEGRGDGTCEEGSSGAEHWQDEEREKG---EKDKGRGEMERPGEGEKELAEKE 700
Query: 219 DDEKVKGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLH 278
+ +K GE + R++G + +R N +M++ E+ + G G +++E ++ E
Sbjct: 701 EWKKRDGEEQEQKEREQGHQKER---NQEMEEGGEE-EHGEG-----EEEEGDREEEEEK 751
Query: 279 EKEAKDDSKTKTPEKQTPSGPTKPSEGPAKVEEEA 313
E E K++ + + E G + EG K EE A
Sbjct: 752 EGEGKEEGEGEEVE-----GEREKEEGERKKEERA 781
Score = 47.0 bits (110), Expect = 5e-05
Identities = 53/219 (24%), Positives = 96/219 (43%), Gaps = 27/219 (12%)
Query: 27 EEMEELEKELDVVDPDGSVPVGLRQRNQTEKQSTGVYNREAMLNFCEKETKKLMQREMSM 86
EE EE E E + + +G G + + E + G E E+E + +
Sbjct: 923 EEGEEGEGEGEEEEGEGEGEDGEGEGEEEEGEWEG--EEEEGEGEGEEEGEGEGEEGEGE 980
Query: 87 DESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSG 146
E ++ E + + + GEE G + + G G+E + G ++ E G+ G
Sbjct: 981 GEEEEGEGEGEEEEGEEEGEEEGE---GEEEGEGEGEEEEEGEVE-------GEVEGEEG 1030
Query: 147 EKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDK 206
E EE+ G ++G +E K+G GEE ++EEE++G + TG ++ +
Sbjct: 1031 EGEGEEE--EGEEEG--------EEREKEGEGEENRRNREEEEEEEGKYQETGEEENERQ 1080
Query: 207 KREEMKEVAK-----KEDDEKVKGERRNTDTRKEGEKMK 240
EE K+V+K K K ++ T+T+ G++ +
Sbjct: 1081 DGEEYKKVSKIKGSVKYGKHKTYQKKSVTNTQGNGKEQR 1119
>gi|116008442 zinc finger CCCH-type containing 13 [Homo sapiens]
Length = 1564
Score = 62.0 bits (149), Expect = 2e-09
Identities = 51/240 (21%), Positives = 107/240 (44%), Gaps = 10/240 (4%)
Query: 82 REMSMDES-KQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDE 140
R+ + D S ++ + D ++ ER + S R+ +L ++ +R + DR +
Sbjct: 614 RDQARDSSFERRHGERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRD 673
Query: 141 AGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGL 200
+ ++ +E R ++ R R +E K+ E ++ E +K DR
Sbjct: 674 ERARERDRERE----RDRERERERERERDREREKERELERERAREREREREKERDRERDR 729
Query: 201 SRDKDKKREEMKEVAKKEDDEKVKGER---RNTDTRKEGEKMKRAGGNTDMKKEDEKVKR 257
RD D++RE +E ++++ E+ + ER R + +E E+ + + KE E+ +R
Sbjct: 730 DRDHDRERERERERDREKEREREREERERERERERERERERERERERARERDKERER-QR 788
Query: 258 GTGNTDTKKDDEKVKKNEPLHEKEAKD-DSKTKTPEKQTPSGPTKPSEGPAKVEEEAAPS 316
+ D +DD + K+ E ++ +D + K+ ++ G P + P + E + S
Sbjct: 789 DWEDKDKGRDDRREKREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDS 848
Score = 58.5 bits (140), Expect = 2e-08
Identities = 58/271 (21%), Positives = 116/271 (42%), Gaps = 28/271 (10%)
Query: 73 EKETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGPR-RDSDLGKEPKRGGLK 131
E++ ++ +RE D ++ E + + + ER R+ K+ R RD D +E +R
Sbjct: 684 ERDRERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERER---- 739
Query: 132 KSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEK 191
R+RD + E+ + E+ ++ R R ++E R ERA KE E+
Sbjct: 740 ---ERERDREKEREREREERER-----ERERERERERERE-----RERERARERDKERER 786
Query: 192 KGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKKE 251
+ DKDK R++ +E K+E+ + + R D RK ++ + G + +
Sbjct: 787 QRD------WEDKDKGRDDRRE--KREEIREDRNPRDGHDERKSKKRYRNEGSPSPRQSP 838
Query: 252 DEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEGPAKVEE 311
+ + + D+K +K+ L + +S++ +P T + E K E
Sbjct: 839 KRRREHSPDSDAYNSGDDKNEKHRLLSQVVRPQESRSLSPSHLTEDRQGRWKEEDRKPER 898
Query: 312 EAAPSIFDEP--LERVKNNDPEMTEVNVNNS 340
+ + ++E E+V + D + + + S
Sbjct: 899 KESSRRYEEQELKEKVSSVDKQREQTEILES 929
Score = 47.0 bits (110), Expect = 5e-05
Identities = 44/264 (16%), Positives = 107/264 (40%), Gaps = 10/264 (3%)
Query: 73 EKETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLKK 132
E++ + +R+ + + + D +ER + + RRD + + +
Sbjct: 628 ERDRRDNRERDQRPSSPIRHQGRNDELERDERREERRVDRVDDRRDERARERDRERERDR 687
Query: 133 SFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKK 192
R+R+ + EK +E + R ++ R R +E +D + ++ + +K
Sbjct: 688 ERERERERERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREK 747
Query: 193 GSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKKED 252
+R +++++RE +E ++ + E+ + R+ + ++ + + G D +++
Sbjct: 748 ERERE---REERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKR 804
Query: 253 EKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKP--SEGPAKVE 310
E+++ D D+ K KK + S ++P+++ P + G K E
Sbjct: 805 EEIREDRNPRD-GHDERKSKK----RYRNEGSPSPRQSPKRRREHSPDSDAYNSGDDKNE 859
Query: 311 EEAAPSIFDEPLERVKNNDPEMTE 334
+ S P E + +TE
Sbjct: 860 KHRLLSQVVRPQESRSLSPSHLTE 883
Score = 47.0 bits (110), Expect = 5e-05
Identities = 60/295 (20%), Positives = 112/295 (37%), Gaps = 36/295 (12%)
Query: 50 RQRNQTEKQSTGVYNREAMLNFCEKETKKLMQREMSMDESKQVETKTDAKNGEERGRDAS 109
R+R + E++ RE E+E ++ +R+ + + E K ++ R+
Sbjct: 751 REREERERERERERERERER---ERERERARERDKERERQRDWEDKDKGRDDRREKREEI 807
Query: 110 KKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDK 169
++ PR D K KR + S S R + P + G DK + +
Sbjct: 808 REDRNPRDGHDERKSKKRYRNEGSPS-PRQSPKRRREHSPDSDAYNSGDDKNEKHRLLSQ 866
Query: 170 KEAGKDGRGEERAVATK------KEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKV 223
++ R + T+ KEE++K + + ++ + +E++ V K+ + ++
Sbjct: 867 VVRPQESRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEI 926
Query: 224 ---------------KGERRNTDTRKEGEKMKRAGGNTD--MKKEDEKVKRGTGNTDTKK 266
+ E R T R E K+A KK+++ V GN +T
Sbjct: 927 LESSRMRAQDIIGHHQSEDRETSDRAHDENKKKAKIQKKPIKKKKEDDVGIERGNIETTS 986
Query: 267 DDEKV--------KKNEPLHEKEAKDDSKTKTPEKQTPSGPTK-PSEGPAKVEEE 312
+D +V KK+ K++K DS E S + P P +EE
Sbjct: 987 EDGQVFSPKKGQKKKSIEKKRKKSKGDSDISDEEAAQQSKKKRGPRTPPITTKEE 1041
Score = 45.1 bits (105), Expect = 2e-04
Identities = 49/303 (16%), Positives = 128/303 (42%), Gaps = 24/303 (7%)
Query: 50 RQRNQTEKQSTGVYNREAMLNFCEKETKKLMQREMSMDESKQVETKTDAKNGEERGRDAS 109
R+R++ ++ + A E+E ++ +R+ D ++ E + + +ER R+
Sbjct: 695 RERDREREKERELERERAREREREREKERDRERDRDRDHDRERERERERDREKERERERE 754
Query: 110 KKALGPRRDSDLGKEPKRGGLK-----KSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVR 164
++ R+ + +E +R + K R RD G + EK + R
Sbjct: 755 ERERERERERERERERERERERARERDKERERQRDWEDKDKGRDDRREKREEIREDRNPR 814
Query: 165 AAVDKKEAGK----DGRGEERAVATKKEEEKKGSDR-NTGLSRDKDKKREEMKEVAKKED 219
D++++ K +G R ++ E SD N+G DK++K + +V + ++
Sbjct: 815 DGHDERKSKKRYRNEGSPSPRQSPKRRREHSPDSDAYNSG--DDKNEKHRLLSQVVRPQE 872
Query: 220 DEKVKGERRNTDT--RKEGEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPL 277
+ D R + E K + + E++++K + D +++ ++ ++ +
Sbjct: 873 SRSLSPSHLTEDRQGRWKEEDRKPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRM 932
Query: 278 HEKEAKDDSKTKTPEKQTPSGPTKPSEGPAKVEEEAAPSIFDEPLERVKNNDPEMTEVNV 337
++ +++ +++T ++ AK+++ +P+++ K +D + N+
Sbjct: 933 RAQDIIGHHQSE--DRETSDRAHDENKKKAKIQK--------KPIKKKKEDDVGIERGNI 982
Query: 338 NNS 340
+
Sbjct: 983 ETT 985
Score = 38.5 bits (88), Expect = 0.018
Identities = 47/224 (20%), Positives = 87/224 (38%), Gaps = 28/224 (12%)
Query: 74 KETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLKKS 133
K +K R E K+ + D + + ++S+ R +G
Sbjct: 895 KPERKESSRRYEEQELKEKVSSVDKQREQTEILESSRM----RAQDIIGHHQSEDRETSD 950
Query: 134 FSRDRDEAGGKSGEKP----KEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEE 189
+ D ++ K +KP KE+ + GI++G + + + +G+++ KK +
Sbjct: 951 RAHDENKKKAKIQKKPIKKKKEDDV--GIERGNIETTSEDGQVFSPKKGQKKKSIEKKRK 1008
Query: 190 EKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMK 249
+ KG D D EE + +KK+ +G R T KE E ++ G +
Sbjct: 1009 KSKG---------DSDISDEEAAQQSKKK-----RGPRTPPITTKE-ELVEMCNGKNGI- 1052
Query: 250 KEDEKVKRGTGNTDTKKDD--EKVKKNEPLHEKEAKDDSKTKTP 291
ED + K T +D +D ++ + E H A T +P
Sbjct: 1053 LEDSQKKEDTAFSDWSDEDVPDRTEVTEAEHTATATTPGSTPSP 1096
Score = 33.9 bits (76), Expect = 0.44
Identities = 46/237 (19%), Positives = 97/237 (40%), Gaps = 29/237 (12%)
Query: 52 RNQTEKQSTGVYNREAMLNFCEKETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKK 111
R+ T + N A + ++ +K + S D K TK+ GE + R K
Sbjct: 1199 RSHTSGRLRSPSNDSAHRSGDDQSGRKRVLHSGSRDREK---TKSLEITGERKSRIDQLK 1255
Query: 112 ALGPRRDSDLGKEPKRGGLKKSFSRDRD-EAGGKSGEKPKEEKIIRGIDKGRVRAAVDKK 170
P R + ++ R + S + D + +SG +++ D+
Sbjct: 1256 RGEPSRSTSSDRQDSRSHSSRRSSPESDRQVHSRSGSFDSRDRLQER----------DRY 1305
Query: 171 EAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNT 230
E ++ E R T++ E + +D++ +RD+D+ RE +E + + +RR+
Sbjct: 1306 EHDRERERERRD--TRQREWDRDADKDWPRNRDRDRLRERERE--------RERDKRRDL 1355
Query: 231 DTRKEGEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSK 287
D +E E++ D ++ ++ + K+ + K+ E HE++ + S+
Sbjct: 1356 D--RERERLISDSVERDRDRDRDRTFESSQIESVKRCEAKL---EGEHERDLESTSR 1407
Score = 32.7 bits (73), Expect = 0.98
Identities = 58/317 (18%), Positives = 114/317 (35%), Gaps = 45/317 (14%)
Query: 51 QRNQTEKQSTGVYNREAMLNFCEKETKKLMQREMSMDESKQVETKT---DAKNGE----- 102
Q+ TE+ S+ V + EKE K+ + E + VE +T D+ NG+
Sbjct: 101 QKRNTEESSSPVRKESSRGRHREKEDIKITKERTPESEEENVEWETNRDDSDNGDINYDY 160
Query: 103 ------ERGRDASKKALGPRRDSDLGK------------EPKRGGLKKSFSRDRDEAGGK 144
E R ++ L ++ K E R L S S + K
Sbjct: 161 VHELSLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPK 220
Query: 145 SGEKPKEEKIIRGIDKGRVRAAV-----DKKEAGKDGRGEERAVATKKEEEKKGSDRNTG 199
PK + K R +AV D++ K + +++ T D G
Sbjct: 221 RKSSPKSSSASK---KDRKTSAVSSPLLDQQRNSKTNQSKKKGPRTPSPPPPIPEDIALG 277
Query: 200 LSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVKRGT 259
KK +E +V + +++ G+ R D ++ EK + + + +
Sbjct: 278 ------KKYKEKYKVKDRIEEKTRDGKDRGRDFERQREKRDKPRSTSPAGQHHSPIS-SR 330
Query: 260 GNTDTKKDDEKVKKNEPLHEKE---AKDDSKTKTPEKQTPSGPTKPSEGPAKVEEEAAPS 316
++ + + ++++ P ++ + +T TP + + P PS + + + +P
Sbjct: 331 HHSSSSQSGSSIQRHSPSPRRKRTPSPSYQRTLTPPLRRSASP-YPSHSLSSPQRKQSPP 389
Query: 317 IFDEPLERVKNNDPEMT 333
P+ +D E T
Sbjct: 390 RHRSPMREKGRHDHERT 406
Score = 30.4 bits (67), Expect = 4.9
Identities = 34/178 (19%), Positives = 70/178 (39%), Gaps = 20/178 (11%)
Query: 110 KKALGPRRDSDLGKEPKR----GGLKKSFSRDRDEAGG--KSGEKPKEEKIIRGIDKGRV 163
+K + +R S LG G +S S D G +SG K +++ + R
Sbjct: 1181 RKPMDQKRSSSLGSNRSNRSHTSGRLRSPSNDSAHRSGDDQSGRK----RVLHSGSRDR- 1235
Query: 164 RAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKV 223
+K + GE ++ + ++ K + + S D+ R + E D +V
Sbjct: 1236 -----EKTKSLEITGERKS----RIDQLKRGEPSRSTSSDRQDSRSHSSRRSSPESDRQV 1286
Query: 224 KGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKE 281
+ D+R ++ R + + ++E ++ + D KD + + + L E+E
Sbjct: 1287 HSRSGSFDSRDRLQERDRYEHDRERERERRDTRQREWDRDADKDWPRNRDRDRLRERE 1344
Score = 30.0 bits (66), Expect = 6.3
Identities = 25/97 (25%), Positives = 48/97 (49%), Gaps = 7/97 (7%)
Query: 470 NMDKQRQKRLQEQRQAQEAKGEKKDLL----EVPKAGAVAKGSPKPSPQPSPK-PSPKNS 524
+++ +RQK +E + ++ EK++ + EV +K SP PS + S K P K+S
Sbjct: 165 SLEMKRQKIQRELMKLEQENMEKREEIIIKKEVSPEVVRSKLSPSPSLRKSSKSPKRKSS 224
Query: 525 PKKGGAPAAPPPPPPPLAPPLIMENLKNSLSPATQRK 561
PK A +P +++ +NS + +++K
Sbjct: 225 PKSSSASKKDRKTSAVSSP--LLDQQRNSKTNQSKKK 259
Score = 29.6 bits (65), Expect = 8.3
Identities = 22/108 (20%), Positives = 46/108 (42%), Gaps = 11/108 (10%)
Query: 191 KKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKK 250
+KG + S+ D++ E ++ K D EK D+R+E E + + D +
Sbjct: 397 EKGRHDHERTSQSHDRRHERREDTRGKRDREK--------DSREEREYEQDQSSSRD-HR 447
Query: 251 EDEKVKRGTGNTDTK--KDDEKVKKNEPLHEKEAKDDSKTKTPEKQTP 296
+D + + G D + +D +++ + + + D T E + P
Sbjct: 448 DDREPRDGRDRRDARDTRDRRELRDSRDMRDSREMRDYSRDTKESRDP 495
>gi|44680105 caldesmon 1 isoform 1 [Homo sapiens]
Length = 793
Score = 61.6 bits (148), Expect = 2e-09
Identities = 70/335 (20%), Positives = 150/335 (44%), Gaps = 41/335 (12%)
Query: 18 DSLLETLSPEEMEELEKELDVVD-PDGSVPVGLRQRNQTEKQSTGVYNREAMLNFCEKET 76
++ +E + E+ E ++E V+ +G + ++ + +Q + + + +KE
Sbjct: 205 ENQVEVMVEEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKER 264
Query: 77 KKLMQREMSMDESKQVETKTDAKNGEERGR-DASKKALGPRRDSDLGKEPKRGGLKKSFS 135
+ + + +E ++++ + D K +ER R +A +KA R+ +E +R
Sbjct: 265 AEAERARLEAEERERIKAEQDKKIADERARIEAEEKAAAQERERREAEERER-------M 317
Query: 136 RDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSD 195
R+ ++ + ++ KEE+ RAA +++ KEEEK+ ++
Sbjct: 318 REEEKRAAEERQRIKEEE---------KRAAEERQRI--------------KEEEKRAAE 354
Query: 196 RNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKKEDEKV 255
+ ++++K+ E ++ A+ E++EK K E + + K+ E+ K A T +K E +
Sbjct: 355 ERQRI-KEEEKRAAEERQRARAEEEEKAKVEEQKRN--KQLEEKKHAMQETKIKGEKVEQ 411
Query: 256 KRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEGPAKVEEEAAP 315
K + KK E + L K+ ++ TK K+ KP+ ++++E
Sbjct: 412 KIEGKWVNEKKAQEDKLQTAVL--KKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIK 469
Query: 316 SIFDEPLERVK---NNDPEMTEVNVNNSDCITNEI 347
EP E VK + TEV N + +T+++
Sbjct: 470 K-DKEPKEEVKSFMDRKKGFTEVKSQNGEFMTHKL 503
Score = 58.2 bits (139), Expect = 2e-08
Identities = 72/315 (22%), Positives = 132/315 (41%), Gaps = 73/315 (23%)
Query: 27 EEMEELEKELD--VVDPDGSVPVGLRQRNQTEKQSTGVYNREAMLNFCEKETKKLMQREM 84
+E E +KE D + D S+P Q + E ++T EKE K ++E
Sbjct: 112 QEALERQKEFDPTITDASLSLPSRRMQNDTAENETT------------EKEEKSESRQER 159
Query: 85 SMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGL---------KKSFS 135
E + TK+ KN + R + +KK ++ + ++PKRG + ++ +
Sbjct: 160 YEIEETETVTKSYQKN-DWRDAEENKKE-DKEKEEEEEEKPKRGSIGENQVEVMVEEKTT 217
Query: 136 RDRDEA-------GGKSGEKPKEEKI----------------------------IRGIDK 160
++E G S E+PK+E+ + ++
Sbjct: 218 ESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISHHEKMEEEDKERAEAERARLEAEER 277
Query: 161 GRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDD 220
R++A DKK A + R E A +E E++ ++ ++++ REE K A++
Sbjct: 278 ERIKAEQDKKIADERARIEAEEKAAAQERERREAE-------ERERMREEEKRAAEERQR 330
Query: 221 EKVKGERRNTDTRKEGEKMKRAGGNTDMKKEDEK-----VKRGTGNTDTKKDDEKVKKNE 275
K + +R + ++ E+ KRA KE+EK +R + K E+ K+N+
Sbjct: 331 IKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAKVEEQKRNK 390
Query: 276 PLHEKE-AKDDSKTK 289
L EK+ A ++K K
Sbjct: 391 QLEEKKHAMQETKIK 405
Score = 49.3 bits (116), Expect = 1e-05
Identities = 67/340 (19%), Positives = 143/340 (42%), Gaps = 41/340 (12%)
Query: 3 RVAKYRRQVSEDPDIDSLLETLSPEEMEELEKELDVVDPDGSVPVGLRQRNQTEKQSTGV 62
R A+ R+++ E+ + EE + +E + + RQR + E++
Sbjct: 323 RAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRIKEEEKRAAEERQRARAEEEEKAK 382
Query: 63 YNREAMLNFCEKETKKLMQREMSMDESK----QVETKTDAKNGEERGRDASKKALGPRRD 118
+ K K+L +++ +M E+K +VE K + K E+ K +
Sbjct: 383 VEEQ-------KRNKQLEEKKHAMQETKIKGEKVEQKIEGKWVNEKKAQEDKL-----QT 430
Query: 119 SDLGKEPKRGGLKKSFSRDR--DEAGGKSGEKPKEEKIIRGID-KGRVRAAVDKKEAGKD 175
+ L K+ + G K R++ ++ E+ K+EKI + + K V++ +D+K+ +
Sbjct: 431 AVLKKQGEEKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKEEVKSFMDRKKGFTE 490
Query: 176 GRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREE----------MKEVAKK------ED 219
+ + T K + + + G D K E ++E+ ++ E+
Sbjct: 491 VKSQNGEFMTHKLKHTENTFSRPGGRASVDTKEAEGAPQVEAGKRLEELRRRRGETESEE 550
Query: 220 DEKVKGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHE 279
EK+K +++ E K KR +++E+++ K+ + ++++EK + E +
Sbjct: 551 FEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEADRKLREEEEKRRLKEEIER 610
Query: 280 KEAK-DDSKTKTPE-----KQTPSGPTKPSEGPAKVEEEA 313
+ A+ + + K PE + P P K+EE A
Sbjct: 611 RRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERA 650
Score = 40.0 bits (92), Expect = 0.006
Identities = 61/300 (20%), Positives = 118/300 (39%), Gaps = 41/300 (13%)
Query: 51 QRNQTEKQSTGVYNREAMLNFCEKETKKLMQRE--------MSMDESKQVETKTDAKNGE 102
++ Q +K T V ++ EK TK +RE +E K + K D + E
Sbjct: 421 KKAQEDKLQTAVLKKQGE----EKGTKVQAKREKLQEDKPTFKKEEIKDEKIKKDKEPKE 476
Query: 103 ERGRDASKKALGPRRDSDLGK--EPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDK 160
E +K S G+ K + +FSR GG++ KE + ++
Sbjct: 477 EVKSFMDRKKGFTEVKSQNGEFMTHKLKHTENTFSRP----GGRASVDTKEAEGAPQVEA 532
Query: 161 G-------RVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKE 213
G R R + +E K + ++ A +E +KK +R L ++ ++++E +
Sbjct: 533 GKRLEELRRRRGETESEEFEKLKQKQQEAALELEELKKKREERRKVLEEEEQRRKQEEAD 592
Query: 214 VAKKEDDE----KVKGERRNTDTRKEGEKMKRAGGNTDMK------------KEDEKVKR 257
+E++E K + ERR + ++ +KM G + D K K +E+ +
Sbjct: 593 RKLREEEEKRRLKEEIERRRAEAAEKRQKMPEDGLSDDKKPFKCFTPKGSSLKIEERAEF 652
Query: 258 GTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEGPAKVEEEAAPSI 317
+ + + + + +++ + T E + PTKP+ V E +I
Sbjct: 653 LNKSVQKSSGVKSTHQAAIVSKIDSRLEQYTSAIEGTKSAKPTKPAASDLPVPAEGVRNI 712
Score = 35.8 bits (81), Expect = 0.12
Identities = 26/120 (21%), Positives = 46/120 (38%), Gaps = 3/120 (2%)
Query: 181 RAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMK 240
R + +K EE + R+ D + E +E ++ E++ R+ + G+
Sbjct: 8 RELRRQKREEMRLEAERIAYQRNDDDEEEAARERRRRARQERL---RQKQEEESLGQVTD 64
Query: 241 RAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPT 300
+ N DE+ K T NT + DDE +E + + E+Q PT
Sbjct: 65 QVEVNAQNSVPDEEAKTTTTNTQVEGDDEAAFLERLARREERRQKRLQEALERQKEFDPT 124
Score = 34.3 bits (77), Expect = 0.34
Identities = 38/221 (17%), Positives = 92/221 (41%), Gaps = 12/221 (5%)
Query: 137 DRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAG-KDGRGEERAVATKKEEEKKGSD 195
D +EA + + ++E++ + ++ + D+ E ++ +E A T + +G D
Sbjct: 33 DEEEAARERRRRARQERLRQKQEEESLGQVTDQVEVNAQNSVPDEEAKTTTTNTQVEGDD 92
Query: 196 RNT---GLSRDKDKKREEMKEVAK--KEDDEKVKGERRNTDTRK-EGEKMKRAGGNTDMK 249
L+R ++++++ ++E + KE D + + +R+ + + + + K
Sbjct: 93 EAAFLERLARREERRQKRLQEALERQKEFDPTITDASLSLPSRRMQNDTAENETTEKEEK 152
Query: 250 KEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEGPAKV 309
E + + T+T + E + +D K + E++ G ++ V
Sbjct: 153 SESRQERYEIEETETVTKSYQKNDWRDAEENKKEDKEKEEEEEEKPKRGSIGENQVEVMV 212
Query: 310 EEEAAPSIFDEPLERVKN-----NDPEMTEVNVNNSDCITN 345
EE+ S + + +KN +P+ E SD I++
Sbjct: 213 EEKTTESQEETVVMSLKNGQISSEEPKQEEEREQGSDEISH 253
>gi|21361282 splicing factor, arginine/serine-rich 4 [Homo sapiens]
Length = 494
Score = 60.5 bits (145), Expect = 4e-09
Identities = 61/324 (18%), Positives = 125/324 (38%), Gaps = 35/324 (10%)
Query: 18 DSLLETLSPEEMEELEKELDVVDPDGSVPVGLRQRNQTEKQSTGVYNREAMLNFCEKETK 77
+ ++E +S +M+ ++LD + +G ++ + + G R +
Sbjct: 142 EGVIEFVSYSDMKRALEKLDGTEVNG-------RKIRLVEDKPGSRRRRSYSRSRSHSRS 194
Query: 78 KLMQREMSMDESKQVETKTDAKNGEERGRDASK---KALGPRRDSDLGKEPKRGGLKKSF 134
+ R S+ +K+ R R S+ K+ + K+ K K
Sbjct: 195 RSRSRHSRKSRSRSGSSKSSHSKSRSRSRSGSRSRSKSRSRSQSRSRSKKEKSRSPSKEK 254
Query: 135 SRDRDEAGGKSGEKPK---EEKIIRGIDKGRVRAAVDKKEAGKD---GRGEERAVATKKE 188
SR R + GKS K K EEKI + G+ ++ + K R +ER V +K
Sbjct: 255 SRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKSKSKSRSRSQERRVEEEKR 314
Query: 189 --------EEK-----------KGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRN 229
+EK KG R+ SR K K + + ++ +++E + + ++
Sbjct: 315 GSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKGRKRSREESRSRSRSRSKS 374
Query: 230 TDTRKEGEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTK 289
+RK G K G++ KK+++ + + + E+ ++E + +S+
Sbjct: 375 ERSRKRGSKRDSKAGSSKKKKKEDTDRSQSRSPSRSVSKEREHAKSESSQREGRGESENA 434
Query: 290 TPEKQTPSGPTKPSEGPAKVEEEA 313
++T S S+ + E+
Sbjct: 435 GTNQETRSRSRSNSKSKPNLPSES 458
Score = 53.1 bits (126), Expect = 7e-07
Identities = 53/267 (19%), Positives = 100/267 (37%), Gaps = 22/267 (8%)
Query: 50 RQRNQTEKQSTGVYNREAMLNFCEKETKKLMQREMSMDESKQVETKTDAKNGEERGRDAS 109
+ R++++K+ + ++E + K + + +E Q R S
Sbjct: 237 QSRSRSKKEKSRSPSKEKSRSRSHSAGKSRSKSKDQAEEKIQNNDNVGKPKSRSPSRHKS 296
Query: 110 KKALGPRRDSDLGKEPKRGGL------KKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRV 163
K R +E KRG + +KS + R + K G + + + DK +
Sbjct: 297 KSKSRSRSQERRVEEEKRGSVSRGRSQEKSLRQSRSRSRSKGGSRSRSRSRSKSKDKRKG 356
Query: 164 RAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKV 223
R K + ++ R R+ + + K+GS R++ K K KKED ++
Sbjct: 357 R-----KRSREESRSRSRSRSKSERSRKRGSKRDSKAGSSKKK---------KKEDTDRS 402
Query: 224 KGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEK-EA 282
+ + KE E K + + E E + + K K N P + +
Sbjct: 403 QSRSPSRSVSKEREHAKSESSQREGRGESENAGTNQETRSRSRSNSKSKPNLPSESRSRS 462
Query: 283 KDDSKTKTPEK-QTPSGPTKPSEGPAK 308
K SKT++ K ++ S PS ++
Sbjct: 463 KSASKTRSRSKSRSRSASRSPSRSRSR 489
>gi|134948605 ankyrin repeat domain 12 isoform 2 [Homo sapiens]
Length = 2039
Score = 59.3 bits (142), Expect = 1e-08
Identities = 80/362 (22%), Positives = 147/362 (40%), Gaps = 50/362 (13%)
Query: 7 YRRQVSEDPDIDSLLETLSPEEMEELEKELDVVDPDGSVPVGLRQRNQTEKQSTGVYNRE 66
++ +ED ++ E+L+ E+ +LEK + D S + + K+ +E
Sbjct: 678 FKSDETEDLFLNMEHESLTLEKKSKLEKN---IKDDKSTKEKHVSKERNFKEERDKIKKE 734
Query: 67 AMLNFCEKETKKLMQREMSMDESKQVETKTDAKNGEER--GRDASKKALGPRRDSDLGKE 124
+ +F E++ K L + ++ K E + + E G +K + + KE
Sbjct: 735 SEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKE 794
Query: 125 PKRGGLKKSFSRDRD--EAGGKSGEKPKEEKIIRGIDKGRVRAA--VDKKEAGKDGRGEE 180
K K+S +++D + K+ EK K+ K +K ++ + VDK + KD
Sbjct: 795 SKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKE-KDKLYSH 853
Query: 181 RAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEG--EK 238
KE EK + + D++K RE+M +K D EK + ER +++++ EK
Sbjct: 854 HTEKCHKEGEKSKNTAAIKKTDDREKSREKMD---RKHDKEKPEKERHLAESKEKHLMEK 910
Query: 239 MKRAGGNTDM----------------KKEDEKVKRGTGNTDTKKDDEKVKK-----NEPL 277
+ N++ KKE + K T++K E+ K N+
Sbjct: 911 KNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQ 970
Query: 278 HEKEAKDDSKTKTPEKQTPSGPTKPSEGPAKVEEEAAPSIFDEPLERVKNNDPEMTEVNV 337
HEK KTK +TP G K + D+ ++R K D ++ +
Sbjct: 971 HEKPLSLKEKTKDEPLKTPDGKEKDKK--------------DKDIDRYKERDKHKDKIQI 1016
Query: 338 NN 339
N+
Sbjct: 1017 NS 1018
Score = 49.3 bits (116), Expect = 1e-05
Identities = 70/288 (24%), Positives = 116/288 (40%), Gaps = 49/288 (17%)
Query: 74 KETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLKKS 133
K K+ ++E + ESK+ + KN + + SK G ++ D + KK
Sbjct: 887 KHDKEKPEKERHLAESKEKHLM-EKKNKQSDNSEYSKSEKGKNKEKDRELD------KKE 939
Query: 134 FSRDRDEAGGKSGEKPKEEKIIRGID--KGRVRAAVDKKEAGKDGRGEERAVATKKEEEK 191
SRD++ + + +EEK +D K + + KE KD E KE++K
Sbjct: 940 KSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKD---EPLKTPDGKEKDK 996
Query: 192 KGSDRNTGLSRDKDKKREEMKEVAK---KEDDEKVKGERRNTDTRKEGEKM--------- 239
K D + RDK K + ++ + K + D K K + DTR + +++
Sbjct: 997 KDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTS 1056
Query: 240 -KRAGGNTDM------KKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTK--- 289
+R D+ KK EK+K +K+ E+++ L E + KD KTK
Sbjct: 1057 FERMLSLKDLEIEQWHKKHKEKIK--------QKEKERLRNRNCL-ELKIKDKEKTKHTP 1107
Query: 290 TPEKQTPSGPTKPSEGPAKVEEEAAPSIFDEPLERVKNNDPEMTEVNV 337
T K +K SE +E +P + V N + NV
Sbjct: 1108 TESKNKELTRSKSSEVTDAYTKE------KQPKDAVSNRSQSVDTKNV 1149
Score = 37.7 bits (86), Expect = 0.030
Identities = 50/257 (19%), Positives = 105/257 (40%), Gaps = 33/257 (12%)
Query: 56 EKQSTGVYNREAMLNFCEKETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGP 115
E S N + L +KE K L + ++ E ++ + K + + +E+
Sbjct: 604 EDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEK----------- 652
Query: 116 RRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKD 175
+ D KE L++S DR+ + + E + ++ + ++KK
Sbjct: 653 YKTKDSAKE-----LQRSVEFDREFWKENFFKSDETEDLFLNMEHESL--TLEKKSK--- 702
Query: 176 GRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKE 235
E+ + K ++K + ++DK ++E ++ ++E + +K ER N T K+
Sbjct: 703 ---LEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKD 759
Query: 236 GEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQT 295
E + M +E + G + + D EK +K+ + E + K + +++ EK
Sbjct: 760 SEFT-----SLGMSAIEESI--GLHLVEKEIDIEKQEKH--IKESKEKPEKRSQIKEKDI 810
Query: 296 PSGPTKPSEGPAKVEEE 312
K E K++ E
Sbjct: 811 EKMERKTFEKEKKIKHE 827
Score = 30.8 bits (68), Expect = 3.7
Identities = 35/153 (22%), Positives = 59/153 (38%), Gaps = 42/153 (27%)
Query: 186 KKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVK---------GERRNTDTRKEG 236
+K +K D+ S+ +R ++ + K++ K K E R++DT KEG
Sbjct: 23 EKPYGRKSKDKIASYSKTPKIERSDVSKEMKEKSSMKRKLPFTISPSRNEERDSDTEKEG 82
Query: 237 EKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKE---------AKDDSK 287
E +K K+ GN K + PL E++ A+D+S
Sbjct: 83 -------------PEKKKTKKEAGN--KKSTPVSILFGYPLSERKQMALLMQMTARDNSP 127
Query: 288 TKTP---------EKQTPSGPTKPSEGPAKVEE 311
TP +K+TPS ++ + K E
Sbjct: 128 DSTPNHPSQTTPAQKKTPSSSSRQKDKVNKRNE 160
Score = 29.6 bits (65), Expect = 8.3
Identities = 68/316 (21%), Positives = 129/316 (40%), Gaps = 54/316 (17%)
Query: 56 EKQSTGVYNREAMLNFCEKETKKLMQREMSMDESK----QVETKTDAKNGEERGRDASKK 111
E + G R+ KE ++L Q + + ++ V T D + R +K
Sbjct: 442 EHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSE-KTREEGNFRK 500
Query: 112 ALGPRRDSDL-------GKEPKRG-GLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGR- 162
+ P+ D+ L GK PK GL + S + K+ P ++ D R
Sbjct: 501 SFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRY 560
Query: 163 -------------VRAAVDKKEAG--KDGRGE--ERAVATKKEEEKKGSDRNTGLSRDK- 204
V++ K+++ KD E E++ A K+E+ + N+ + K
Sbjct: 561 DNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKM 620
Query: 205 DKKREEM-------KEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVKR 257
DK+ + + KE K++ ++++GE+ T+ ++++R+ ++ + E K
Sbjct: 621 DKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRS-----VEFDREFWKE 675
Query: 258 GTGNTDTKKDDEKVKKNEPLH-------EKEAKDDSKTKTPEKQTPSGPTKPSEGPAKVE 310
+D +D ++E L EK KDD TK EK S E K++
Sbjct: 676 NFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTK--EKHV-SKERNFKEERDKIK 732
Query: 311 EEAAPSIFDEPLERVK 326
+E+ S +E ++ +K
Sbjct: 733 KESEKSFREEKIKDLK 748
>gi|134948558 ankyrin repeat domain 12 isoform 1 [Homo sapiens]
Length = 2062
Score = 59.3 bits (142), Expect = 1e-08
Identities = 80/362 (22%), Positives = 147/362 (40%), Gaps = 50/362 (13%)
Query: 7 YRRQVSEDPDIDSLLETLSPEEMEELEKELDVVDPDGSVPVGLRQRNQTEKQSTGVYNRE 66
++ +ED ++ E+L+ E+ +LEK + D S + + K+ +E
Sbjct: 701 FKSDETEDLFLNMEHESLTLEKKSKLEKN---IKDDKSTKEKHVSKERNFKEERDKIKKE 757
Query: 67 AMLNFCEKETKKLMQREMSMDESKQVETKTDAKNGEER--GRDASKKALGPRRDSDLGKE 124
+ +F E++ K L + ++ K E + + E G +K + + KE
Sbjct: 758 SEKSFREEKIKDLKEERENIPTDKDSEFTSLGMSAIEESIGLHLVEKEIDIEKQEKHIKE 817
Query: 125 PKRGGLKKSFSRDRD--EAGGKSGEKPKEEKIIRGIDKGRVRAA--VDKKEAGKDGRGEE 180
K K+S +++D + K+ EK K+ K +K ++ + VDK + KD
Sbjct: 818 SKEKPEKRSQIKEKDIEKMERKTFEKEKKIKHEHKSEKDKLDLSECVDKIKE-KDKLYSH 876
Query: 181 RAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEG--EK 238
KE EK + + D++K RE+M +K D EK + ER +++++ EK
Sbjct: 877 HTEKCHKEGEKSKNTAAIKKTDDREKSREKMD---RKHDKEKPEKERHLAESKEKHLMEK 933
Query: 239 MKRAGGNTDM----------------KKEDEKVKRGTGNTDTKKDDEKVKK-----NEPL 277
+ N++ KKE + K T++K E+ K N+
Sbjct: 934 KNKQSDNSEYSKSEKGKNKEKDRELDKKEKSRDKESINITNSKHIQEEKKSSIVDGNKAQ 993
Query: 278 HEKEAKDDSKTKTPEKQTPSGPTKPSEGPAKVEEEAAPSIFDEPLERVKNNDPEMTEVNV 337
HEK KTK +TP G K + D+ ++R K D ++ +
Sbjct: 994 HEKPLSLKEKTKDEPLKTPDGKEKDKK--------------DKDIDRYKERDKHKDKIQI 1039
Query: 338 NN 339
N+
Sbjct: 1040 NS 1041
Score = 49.3 bits (116), Expect = 1e-05
Identities = 70/288 (24%), Positives = 116/288 (40%), Gaps = 49/288 (17%)
Query: 74 KETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLKKS 133
K K+ ++E + ESK+ + KN + + SK G ++ D + KK
Sbjct: 910 KHDKEKPEKERHLAESKEKHLM-EKKNKQSDNSEYSKSEKGKNKEKDRELD------KKE 962
Query: 134 FSRDRDEAGGKSGEKPKEEKIIRGID--KGRVRAAVDKKEAGKDGRGEERAVATKKEEEK 191
SRD++ + + +EEK +D K + + KE KD E KE++K
Sbjct: 963 KSRDKESINITNSKHIQEEKKSSIVDGNKAQHEKPLSLKEKTKD---EPLKTPDGKEKDK 1019
Query: 192 KGSDRNTGLSRDKDKKREEMKEVAK---KEDDEKVKGERRNTDTRKEGEKM--------- 239
K D + RDK K + ++ + K + D K K + DTR + +++
Sbjct: 1020 KDKDIDRYKERDKHKDKIQINSLLKLKSEADKPKPKSSPASKDTRPKEKRLVNDDLMQTS 1079
Query: 240 -KRAGGNTDM------KKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTK--- 289
+R D+ KK EK+K +K+ E+++ L E + KD KTK
Sbjct: 1080 FERMLSLKDLEIEQWHKKHKEKIK--------QKEKERLRNRNCL-ELKIKDKEKTKHTP 1130
Query: 290 TPEKQTPSGPTKPSEGPAKVEEEAAPSIFDEPLERVKNNDPEMTEVNV 337
T K +K SE +E +P + V N + NV
Sbjct: 1131 TESKNKELTRSKSSEVTDAYTKE------KQPKDAVSNRSQSVDTKNV 1172
Score = 37.7 bits (86), Expect = 0.030
Identities = 50/257 (19%), Positives = 105/257 (40%), Gaps = 33/257 (12%)
Query: 56 EKQSTGVYNREAMLNFCEKETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGP 115
E S N + L +KE K L + ++ E ++ + K + + +E+
Sbjct: 627 EDHSPTFENSDCTLKKMDKEGKTLKKHKLKHKEREKEKHKKEIEGEKEK----------- 675
Query: 116 RRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKD 175
+ D KE L++S DR+ + + E + ++ + ++KK
Sbjct: 676 YKTKDSAKE-----LQRSVEFDREFWKENFFKSDETEDLFLNMEHESL--TLEKKSK--- 725
Query: 176 GRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKE 235
E+ + K ++K + ++DK ++E ++ ++E + +K ER N T K+
Sbjct: 726 ---LEKNIKDDKSTKEKHVSKERNFKEERDKIKKESEKSFREEKIKDLKEERENIPTDKD 782
Query: 236 GEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQT 295
E + M +E + G + + D EK +K+ + E + K + +++ EK
Sbjct: 783 SEFT-----SLGMSAIEESI--GLHLVEKEIDIEKQEKH--IKESKEKPEKRSQIKEKDI 833
Query: 296 PSGPTKPSEGPAKVEEE 312
K E K++ E
Sbjct: 834 EKMERKTFEKEKKIKHE 850
Score = 29.6 bits (65), Expect = 8.3
Identities = 68/316 (21%), Positives = 129/316 (40%), Gaps = 54/316 (17%)
Query: 56 EKQSTGVYNREAMLNFCEKETKKLMQREMSMDESK----QVETKTDAKNGEERGRDASKK 111
E + G R+ KE ++L Q + + ++ V T D + R +K
Sbjct: 465 EHKQKGKVKRKLKNQNKNKENQELKQEKEGKENTRITNLTVNTGLDCSE-KTREEGNFRK 523
Query: 112 ALGPRRDSDL-------GKEPKRG-GLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGR- 162
+ P+ D+ L GK PK GL + S + K+ P ++ D R
Sbjct: 524 SFSPKDDTSLHLFHISTGKSPKHSCGLSEKQSTPLKQEHTKTCLSPGSSEMSLQPDLVRY 583
Query: 163 -------------VRAAVDKKEAG--KDGRGE--ERAVATKKEEEKKGSDRNTGLSRDK- 204
V++ K+++ KD E E++ A K+E+ + N+ + K
Sbjct: 584 DNTESEFLPESSSVKSCKHKEKSKHQKDFHLEFGEKSNAKIKDEDHSPTFENSDCTLKKM 643
Query: 205 DKKREEM-------KEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVKR 257
DK+ + + KE K++ ++++GE+ T+ ++++R+ ++ + E K
Sbjct: 644 DKEGKTLKKHKLKHKEREKEKHKKEIEGEKEKYKTKDSAKELQRS-----VEFDREFWKE 698
Query: 258 GTGNTDTKKDDEKVKKNEPLH-------EKEAKDDSKTKTPEKQTPSGPTKPSEGPAKVE 310
+D +D ++E L EK KDD TK EK S E K++
Sbjct: 699 NFFKSDETEDLFLNMEHESLTLEKKSKLEKNIKDDKSTK--EKHV-SKERNFKEERDKIK 755
Query: 311 EEAAPSIFDEPLERVK 326
+E+ S +E ++ +K
Sbjct: 756 KESEKSFREEKIKDLK 771
>gi|42560244 peptidylprolyl isomerase G [Homo sapiens]
Length = 754
Score = 59.3 bits (142), Expect = 1e-08
Identities = 57/268 (21%), Positives = 118/268 (44%), Gaps = 28/268 (10%)
Query: 51 QRNQTEKQSTG---VYNREAMLN-FCEKETKKLMQREMSMDESKQVETKTDAKNGEER-- 104
QR Q + S+G + ++ LN E + + +E + + + V + KN +E+
Sbjct: 367 QRAQRMRVSSGERWIKGDKSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKV 426
Query: 105 -GRDASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGEKPK-------EEKIIR 156
++ K RR+S+ + K K++ S+ R ++ KS K + EEK +R
Sbjct: 427 KDHKSNSKERDIRRNSEKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMR 486
Query: 157 GIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAK 216
KGR V +KE D +G+++ + KE+ K+ ++ K K+++ +
Sbjct: 487 SRSKGRDHENVKEKEKQSDSKGKDQERSRSKEKSKQLESKSNEHDHSKSKEKDRRAQSRS 546
Query: 217 KEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEP 276
+E D N+ TR+ R+ +V+ T + +D + K+
Sbjct: 547 RECDITKGKHSYNSRTRERSRSRDRS----------RRVRSRTHD----RDRSRSKEYHR 592
Query: 277 LHEKEAKDDSKTKTPEKQTPSGPTKPSE 304
E+E + ++++ E++TP G ++ +
Sbjct: 593 YREQEYRRRGRSRSRERRTPPGRSRSKD 620
Score = 58.9 bits (141), Expect = 1e-08
Identities = 62/304 (20%), Positives = 123/304 (40%), Gaps = 30/304 (9%)
Query: 3 RVAKYRRQVSEDPDIDSLLETLSPEEMEELEKELDVVDPDGSVPVGLRQRNQTEKQSTGV 62
R +K+ R +E+ + S + E ++E EK+ D D R R++ + +
Sbjct: 473 RDSKHNR--NEEKRMRSRSKGRDHENVKEKEKQSDSKGKDQE-----RSRSKEKSKQLES 525
Query: 63 YNREAMLNFCEKETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLG 122
+ E + +++ ++ R D +K + R RD S++ D D
Sbjct: 526 KSNEHDHSKSKEKDRRAQSRSRECDITKGKHSYNSRTRERSRSRDRSRRVRSRTHDRDRS 585
Query: 123 KEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERA 182
+ K + R R++ + G E R GR R+ D++ +D R ER
Sbjct: 586 R-------SKEYHRYREQEYRRRGRSRSRE---RRTPPGRSRSK-DRRRRRRDSRSSERE 634
Query: 183 VATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEG--EKMK 240
+ + ++K + + S K+ E + +K D R R + K+K
Sbjct: 635 ESQSRNKDKYRNQESKS-SHRKENSESEKRMYSKSRDHNSSNNSREKKADRDQSPFSKIK 693
Query: 241 RAGGNTDMK------KEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQ 294
++ + ++K KEDEK++ + + + K ++N+ +HEK K D ++ +
Sbjct: 694 QSSQDNELKSSMLKNKEDEKIR---SSVEKENQKSKGQENDHVHEKNKKFDHESSPGTDE 750
Query: 295 TPSG 298
SG
Sbjct: 751 DKSG 754
Score = 43.5 bits (101), Expect = 6e-04
Identities = 48/211 (22%), Positives = 87/211 (41%), Gaps = 19/211 (9%)
Query: 111 KALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKK 170
K GPRR + P R + F R + E + +++ + G DK
Sbjct: 334 KGRGPRRY----RTPSRSRSRDRFRRSETPPHWRQ-EMQRAQRM--RVSSGERWIKGDKS 386
Query: 171 EAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNT 230
E + + V K E+K +D +S ++K E+ K+V + + K + RRN+
Sbjct: 387 ELNEIKENQRSPVRVK---ERKITDHRN-VSESPNRKNEKEKKVKDHKSNSKERDIRRNS 442
Query: 231 DTR-KEGEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKN-------EPLHEKEA 282
+ K K+K+ + K EK K ++ +++EK ++ E + EKE
Sbjct: 443 EKDDKYKNKVKKRAKSKSRSKSKEKSKSKERDSKHNRNEEKRMRSRSKGRDHENVKEKEK 502
Query: 283 KDDSKTKTPEKQTPSGPTKPSEGPAKVEEEA 313
+ DSK K E+ +K E + + +
Sbjct: 503 QSDSKGKDQERSRSKEKSKQLESKSNEHDHS 533
Score = 34.7 bits (78), Expect = 0.26
Identities = 27/144 (18%), Positives = 59/144 (40%), Gaps = 8/144 (5%)
Query: 169 KKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERR 228
KKE K + + ++ + + +++ S D + EE + KK K +
Sbjct: 184 KKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEEKSKKRKK------KHRKN 237
Query: 229 NTDTRKEGEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKE--AKDDS 286
+ +KE +K K++ + + E E ++ +T ++ + +N L K D+
Sbjct: 238 SRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPIPENRFLMRKSPPKADEK 297
Query: 287 KTKTPEKQTPSGPTKPSEGPAKVE 310
+ K E++ P+ PA +
Sbjct: 298 ERKNRERERERECNPPNSQPASYQ 321
Score = 32.7 bits (73), Expect = 0.98
Identities = 21/106 (19%), Positives = 42/106 (39%), Gaps = 5/106 (4%)
Query: 212 KEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVKRGTGNTDTKKDDEKV 271
K KKE+ ++ K ++ + + + + ++D + + +KK +K
Sbjct: 180 KSKVKKEEKKRHKSSSSSSSSSSDSDSSSDSQSSSDSSDSESATEE-----KSKKRKKKH 234
Query: 272 KKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEGPAKVEEEAAPSI 317
+KN H+KE K K+K ++ + V E P I
Sbjct: 235 RKNSRKHKKEKKKRKKSKKSASSESEAENLEAQPQSTVRPEEIPPI 280
Score = 32.3 bits (72), Expect = 1.3
Identities = 55/263 (20%), Positives = 102/263 (38%), Gaps = 56/263 (21%)
Query: 87 DESKQVETKTDAKNGEERGRDASKKALGPRRDSD---LGKEPKRGGLKKSFSRDRD---- 139
D S ++ +D+ + E + SKK R + ++ KR KKS S + +
Sbjct: 205 DSSSDSQSSSDSSDSESATEEKSKKRKKKHRKNSRKHKKEKKKRKKSKKSASSESEAENL 264
Query: 140 EAGGKSGEKPKEEKII---RGIDKGRVRAAVDKKEAGKDGRGE--------------ERA 182
EA +S +P+E I R + + A +K+ ++ E R
Sbjct: 265 EAQPQSTVRPEEIPPIPENRFLMRKSPPKADEKERKNRERERERECNPPNSQPASYQRRL 324
Query: 183 VATKKEEEKKGSD----RNTGLSRDKDK---------KREEMKEVAK---KEDDEKVKGE 226
+ T+ + KG R SR +D+ R+EM+ + + +KG+
Sbjct: 325 LVTRSGRKIKGRGPRRYRTPSRSRSRDRFRRSETPPHWRQEMQRAQRMRVSSGERWIKGD 384
Query: 227 RRNTDTRKEGEKM------------KRAGGNTDMKKEDEKV----KRGTGNTDTKKDDEK 270
+ + KE ++ + + + K E EK K + D +++ EK
Sbjct: 385 KSELNEIKENQRSPVRVKERKITDHRNVSESPNRKNEKEKKVKDHKSNSKERDIRRNSEK 444
Query: 271 VKKNEPLHEKEAKDDSKTKTPEK 293
K + +K AK S++K+ EK
Sbjct: 445 DDKYKNKVKKRAKSKSRSKSKEK 467
>gi|126723060 zinc finger CCCH-type containing 4 [Homo sapiens]
Length = 1303
Score = 58.9 bits (141), Expect = 1e-08
Identities = 32/106 (30%), Positives = 51/106 (48%), Gaps = 2/106 (1%)
Query: 466 LLSRNMDKQRQKRLQEQRQAQEAKGEKKDLLEVPKAGAVAKGSPKPSPQPSPKPSPKNSP 525
LL + + + +++++ +E K + + L P G +P P P SP P
Sbjct: 477 LLDKMLADDAEAGAEDEKEVEELKKQGINPLPKPPPGVGLLPTPPRPPGPQAPTSPNGRP 536
Query: 526 KKGGAPAAPPPPPPPLAPPLIMENLKNSLSP--ATQRKMGDKVLPA 569
+GG P PPPPPPP PP + + LSP Q+ M +K +P+
Sbjct: 537 MQGGPPPPPPPPPPPPGPPQMPMPVHEPLSPQQLQQQDMYNKKIPS 582
Score = 39.3 bits (90), Expect = 0.010
Identities = 41/194 (21%), Positives = 76/194 (39%), Gaps = 15/194 (7%)
Query: 41 PDGSVPVGLRQRNQTEKQSTGVYNREAMLNFCEKE--TKKLMQREMSMDESKQVETKTDA 98
P + P+ + ++ + +S G+Y + E E ++ M +E D +K++ A
Sbjct: 171 PSHATPLPKKAYSKMDSKSYGMYEDYENEQYGEYEGDEEEDMGKEDYDDFTKELNQYRRA 230
Query: 99 KNGEERGRDASKKALGPRRDSDLGKEPKRGGLKKSFSRDRDEAGGKSGEKPKE------- 151
K G RGR + + G R G RG + S R R GG E ++
Sbjct: 231 KEGSSRGRGSRGRGRGYRGRGSRGGSRGRGMGRGSRGRGRGSMGGDHPEDEEDFYEEEMD 290
Query: 152 ----EKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKK 207
E+ + D +++ KD RG R ++ + +G + G R +
Sbjct: 291 YGESEEPMGDDDYDEYSKELNQYRRSKDSRG--RGLSRGRGRGSRGRGKGMGRGRGRGGS 348
Query: 208 REEMKEVAKKEDDE 221
R M + +D++
Sbjct: 349 RGGMNKGGMNDDED 362
Score = 34.7 bits (78), Expect = 0.26
Identities = 36/181 (19%), Positives = 70/181 (38%), Gaps = 18/181 (9%)
Query: 167 VDKKEAGKDGRGEERAVATKKEEEKKGSDRNTGLSRDKDKKREEMKEVAK---KEDDEKV 223
+ +K+ ++ R A ++K++ E + D S D+D+ + + K ++ +
Sbjct: 773 IQQKQQEEEERARRLAESSKQDRENEEGDTGNWYSSDEDEGGSSVTSILKTLRQQTSSRP 832
Query: 224 KGERRNTDTRKEGEKMKRAGGNTDMKKEDEKVKR------------GTGNTDTKKDDEKV 271
+ G+ + G T + D ++ R G+G D+ D ++
Sbjct: 833 PASVGELSSSGLGDPRLQKGHPTGSRLADPRLSRDPRLTRHVEASGGSGPGDSGPSDPRL 892
Query: 272 KKNEPLHEKEAKDDSKTKTPEKQTPSG--PTKPSEGPAKVEEEAAPSIFDEPLERVKNND 329
+ P + E S P SG PT+ EG + E+A +I +PL D
Sbjct: 893 ARALPTSKPEGSLHSSPVGPSSSKGSGPPPTEEEEGERALREKAV-NIPLDPLPGHPLRD 951
Query: 330 P 330
P
Sbjct: 952 P 952
Score = 33.5 bits (75), Expect = 0.57
Identities = 29/118 (24%), Positives = 43/118 (36%), Gaps = 7/118 (5%)
Query: 188 EEEKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTD 247
E E G++ S ++ R+E E + DE+ R +KE EK KR
Sbjct: 63 ELEDDGAEETQDTSGGPERSRKEKGEKHHSDSDEEKSHRRLKRKRKKEREKEKR----RS 118
Query: 248 MKKEDEKVKRGTGNTD---TKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKP 302
K+ K KR ++D DD +E H K + +Q P P
Sbjct: 119 KKRRKSKHKRHASSSDDFSDFSDDSDFSPSEKGHRKYREYSPPYAPSHQQYPPSHATP 176
Score = 32.0 bits (71), Expect = 1.7
Identities = 19/61 (31%), Positives = 27/61 (44%), Gaps = 2/61 (3%)
Query: 484 QAQEAKGEKKDLLEVPKAGAVAKGSPKPSPQPSPKPSPKNSPKKGGAPAAPPPPPPPLAP 543
+A+E +K LE P+ G P+ + + P+ PK APAA PPP
Sbjct: 1184 KAKEPPFVRKSALEQPETGKAGADGGTPTDRYNSYNRPR--PKAAAAPAATTATPPPEGA 1241
Query: 544 P 544
P
Sbjct: 1242 P 1242
Score = 30.4 bits (67), Expect = 4.9
Identities = 18/48 (37%), Positives = 21/48 (43%), Gaps = 5/48 (10%)
Query: 505 AKGSPKPSPQPSPKPSPKNSPKKGGAPAAPP--PPPPPLAPPLIMENL 550
A G+P P P SP P SP P+ PP P P P L+ L
Sbjct: 4 APGTPPPPPSESPPPP---SPPPPSTPSPPPCSPDARPATPHLLHHRL 48
>gi|166235169 PRP38 pre-mRNA processing factor 38 (yeast) domain
containing B [Homo sapiens]
Length = 546
Score = 58.5 bits (140), Expect = 2e-08
Identities = 55/262 (20%), Positives = 105/262 (40%), Gaps = 12/262 (4%)
Query: 73 EKETKKLMQREMSMDESKQVETKTDAKNGEERGRDASKKALGPRRDSDLGKEPKRGGLKK 132
++E ++ +R+ E+K+ E + +RG + + R + + R +K
Sbjct: 292 DRELEREKERQRLEREAKEREKERRRSRSIDRGLERRRS-----RSRERHRSRSRSRDRK 346
Query: 133 SFSRDRDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERA---VATKKEE 189
RDRD K E+ + R DK R ++E ++ E+R+ V KK +
Sbjct: 347 GDRRDRDREREKENERGRRRD--RDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHK 404
Query: 190 EKKGSDRNTGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMKRAGGNTDMK 249
E K R+ RD K+++ + +E + + RN R +++ + +
Sbjct: 405 EDKDDRRHRDDKRDSKKEKKHSRS-RSRERKHRSRSRSRNAGKRSRSRSKEKSSKHKNES 463
Query: 250 KEDEKVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEGPAKV 309
KE + +G+ EK KK E KE K ++++ E+ + + K
Sbjct: 464 KEKSNKRSRSGSQGRTDSVEKSKKREHSPSKE-KSRKRSRSKERSHKRDHSDSKDQSDKH 522
Query: 310 EEEAAPSIFDEPLERVKNNDPE 331
+ + SI E E+ N E
Sbjct: 523 DRRRSQSIEQESQEKQHKNKDE 544
Score = 56.2 bits (134), Expect = 8e-08
Identities = 55/235 (23%), Positives = 97/235 (41%), Gaps = 41/235 (17%)
Query: 95 KTDAKNG--------EERGRDASKKALGPRRD---SDLGKEPKRGGLKKSFSRD------ 137
K D K G E R + +++L PRR S + G SF R+
Sbjct: 241 KKDGKEGAEEIDRHVERRRSRSPRRSLSPRRSPRRSRSRSHHREGHGSSSFDRELEREKE 300
Query: 138 RDEAGGKSGEKPKEEKIIRGIDKGRVRAAVDKKEAGKDGRGEERAVATKKEEEKKGSDRN 197
R ++ E+ KE + R ID+G R + R ER + + ++KG R+
Sbjct: 301 RQRLEREAKEREKERRRSRSIDRGLER---------RRSRSRERHRSRSRSRDRKGDRRD 351
Query: 198 TGLSRDKDKKREEMKEVAKKEDDEKVKGERRNTDTRKEGEKMK--RAGGNTDMKK--EDE 253
RD+++++E + + D +K +G R + + E+ K R+ G + KK ED+
Sbjct: 352 ----RDREREKENERGRRRDRDYDKERGNEREKERERSRERSKEQRSRGEVEEKKHKEDK 407
Query: 254 KVKRGTGNTDTKKDDEKVKKNEPLHEKEAKDDSKTKTPEKQTPSGPTKPSEGPAK 308
+R +DD++ K E H + + K ++ + +G S K
Sbjct: 408 DDRR-------HRDDKRDSKKEKKHSRSRSRERKHRSRSRSRNAGKRSRSRSKEK 455
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.306 0.127 0.343
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 26,091,250
Number of Sequences: 37866
Number of extensions: 1621176
Number of successful extensions: 39506
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 934
Number of HSP's successfully gapped in prelim test: 1303
Number of HSP's that attempted gapping in prelim test: 15459
Number of HSP's gapped (non-prelim): 14686
length of query: 600
length of database: 18,247,518
effective HSP length: 108
effective length of query: 492
effective length of database: 14,157,990
effective search space: 6965731080
effective search space used: 6965731080
T: 11
A: 40
X1: 16 ( 7.1 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 43 (22.0 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.