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Search of human proteins with 169214345
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|169214345 PREDICTED: leucine rich repeat containing 68 [Homo
sapiens]
(625 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|169213924 PREDICTED: leucine rich repeat containing 68 [Homo ... 1249 0.0
gi|169214345 PREDICTED: leucine rich repeat containing 68 [Homo ... 1249 0.0
gi|169213302 PREDICTED: leucine rich repeat containing 68 [Homo ... 1249 0.0
gi|118918429 NOD3 protein [Homo sapiens] 103 5e-22
gi|23503285 leucine rich repeat containing 34 [Homo sapiens] 85 2e-16
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H... 76 1e-13
gi|5174617 nucleotide-binding oligomerization domain containing ... 74 5e-13
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens] 70 4e-12
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens] 70 6e-12
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens] 70 6e-12
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens] 70 6e-12
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens] 70 6e-12
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens] 70 6e-12
gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens] 70 6e-12
gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens] 70 6e-12
gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens] 70 6e-12
gi|168986655 hypothetical protein LOC145497 [Homo sapiens] 70 8e-12
gi|21450705 leucine rich repeat containing 45 [Homo sapiens] 70 8e-12
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens] 69 1e-11
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho... 69 2e-11
gi|116268109 nucleotide-binding oligomerization domains 27 [Homo... 69 2e-11
gi|61175232 hypothetical protein LOC221424 [Homo sapiens] 67 6e-11
gi|11545912 nucleotide-binding oligomerization domain containing... 65 1e-10
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens] 65 1e-10
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho... 64 5e-10
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom... 63 7e-10
gi|4506411 Ran GTPase activating protein 1 [Homo sapiens] 63 7e-10
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens] 62 2e-09
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof... 60 6e-09
gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Ho... 59 1e-08
>gi|169213924 PREDICTED: leucine rich repeat containing 68 [Homo
sapiens]
Length = 625
Score = 1249 bits (3233), Expect = 0.0
Identities = 625/625 (100%), Positives = 625/625 (100%)
Query: 1 MEIAPQEAPPVPGADGDIEEAPAEAGSPSPASPPADGRLKAAAKRVTFPSDEDIVSGAVE 60
MEIAPQEAPPVPGADGDIEEAPAEAGSPSPASPPADGRLKAAAKRVTFPSDEDIVSGAVE
Sbjct: 1 MEIAPQEAPPVPGADGDIEEAPAEAGSPSPASPPADGRLKAAAKRVTFPSDEDIVSGAVE 60
Query: 61 PKDPWRHAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLD 120
PKDPWRHAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLD
Sbjct: 61 PKDPWRHAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLD 120
Query: 121 YKTCEALEEVFKRLQFKVVDLEQTNLDEDPRAEAEPPNLYAQGASALFDMIEYYESATHL 180
YKTCEALEEVFKRLQFKVVDLEQTNLDEDPRAEAEPPNLYAQGASALFDMIEYYESATHL
Sbjct: 121 YKTCEALEEVFKRLQFKVVDLEQTNLDEDPRAEAEPPNLYAQGASALFDMIEYYESATHL 180
Query: 181 NISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLE 240
NISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLE
Sbjct: 181 NISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLE 240
Query: 241 NASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNH 300
NASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNH
Sbjct: 241 NASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNH 300
Query: 301 VLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGN 360
VLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGN
Sbjct: 301 VLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGN 360
Query: 361 EGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLM 420
EGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLM
Sbjct: 361 EGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLM 420
Query: 421 ALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQP 480
ALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQP
Sbjct: 421 ALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQP 480
Query: 481 PQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEEEGERDETP 540
PQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEEEGERDETP
Sbjct: 481 PQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEEEGERDETP 540
Query: 541 SGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHEL 600
SGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHEL
Sbjct: 541 SGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHEL 600
Query: 601 SCSKNEKELEELLLEASQESGQETL 625
SCSKNEKELEELLLEASQESGQETL
Sbjct: 601 SCSKNEKELEELLLEASQESGQETL 625
>gi|169214345 PREDICTED: leucine rich repeat containing 68 [Homo
sapiens]
Length = 625
Score = 1249 bits (3233), Expect = 0.0
Identities = 625/625 (100%), Positives = 625/625 (100%)
Query: 1 MEIAPQEAPPVPGADGDIEEAPAEAGSPSPASPPADGRLKAAAKRVTFPSDEDIVSGAVE 60
MEIAPQEAPPVPGADGDIEEAPAEAGSPSPASPPADGRLKAAAKRVTFPSDEDIVSGAVE
Sbjct: 1 MEIAPQEAPPVPGADGDIEEAPAEAGSPSPASPPADGRLKAAAKRVTFPSDEDIVSGAVE 60
Query: 61 PKDPWRHAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLD 120
PKDPWRHAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLD
Sbjct: 61 PKDPWRHAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLD 120
Query: 121 YKTCEALEEVFKRLQFKVVDLEQTNLDEDPRAEAEPPNLYAQGASALFDMIEYYESATHL 180
YKTCEALEEVFKRLQFKVVDLEQTNLDEDPRAEAEPPNLYAQGASALFDMIEYYESATHL
Sbjct: 121 YKTCEALEEVFKRLQFKVVDLEQTNLDEDPRAEAEPPNLYAQGASALFDMIEYYESATHL 180
Query: 181 NISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLE 240
NISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLE
Sbjct: 181 NISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLE 240
Query: 241 NASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNH 300
NASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNH
Sbjct: 241 NASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNH 300
Query: 301 VLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGN 360
VLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGN
Sbjct: 301 VLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGN 360
Query: 361 EGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLM 420
EGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLM
Sbjct: 361 EGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLM 420
Query: 421 ALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQP 480
ALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQP
Sbjct: 421 ALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQP 480
Query: 481 PQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEEEGERDETP 540
PQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEEEGERDETP
Sbjct: 481 PQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEEEGERDETP 540
Query: 541 SGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHEL 600
SGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHEL
Sbjct: 541 SGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHEL 600
Query: 601 SCSKNEKELEELLLEASQESGQETL 625
SCSKNEKELEELLLEASQESGQETL
Sbjct: 601 SCSKNEKELEELLLEASQESGQETL 625
>gi|169213302 PREDICTED: leucine rich repeat containing 68 [Homo
sapiens]
Length = 625
Score = 1249 bits (3233), Expect = 0.0
Identities = 625/625 (100%), Positives = 625/625 (100%)
Query: 1 MEIAPQEAPPVPGADGDIEEAPAEAGSPSPASPPADGRLKAAAKRVTFPSDEDIVSGAVE 60
MEIAPQEAPPVPGADGDIEEAPAEAGSPSPASPPADGRLKAAAKRVTFPSDEDIVSGAVE
Sbjct: 1 MEIAPQEAPPVPGADGDIEEAPAEAGSPSPASPPADGRLKAAAKRVTFPSDEDIVSGAVE 60
Query: 61 PKDPWRHAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLD 120
PKDPWRHAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLD
Sbjct: 61 PKDPWRHAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLD 120
Query: 121 YKTCEALEEVFKRLQFKVVDLEQTNLDEDPRAEAEPPNLYAQGASALFDMIEYYESATHL 180
YKTCEALEEVFKRLQFKVVDLEQTNLDEDPRAEAEPPNLYAQGASALFDMIEYYESATHL
Sbjct: 121 YKTCEALEEVFKRLQFKVVDLEQTNLDEDPRAEAEPPNLYAQGASALFDMIEYYESATHL 180
Query: 181 NISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLE 240
NISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLE
Sbjct: 181 NISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLE 240
Query: 241 NASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNH 300
NASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNH
Sbjct: 241 NASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNH 300
Query: 301 VLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGN 360
VLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGN
Sbjct: 301 VLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGN 360
Query: 361 EGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLM 420
EGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLM
Sbjct: 361 EGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLM 420
Query: 421 ALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQP 480
ALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQP
Sbjct: 421 ALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQP 480
Query: 481 PQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEEEGERDETP 540
PQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEEEGERDETP
Sbjct: 481 PQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEEEGERDETP 540
Query: 541 SGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHEL 600
SGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHEL
Sbjct: 541 SGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHEL 600
Query: 601 SCSKNEKELEELLLEASQESGQETL 625
SCSKNEKELEELLLEASQESGQETL
Sbjct: 601 SCSKNEKELEELLLEASQESGQETL 625
>gi|118918429 NOD3 protein [Homo sapiens]
Length = 1065
Score = 103 bits (257), Expect = 5e-22
Identities = 80/250 (32%), Positives = 125/250 (50%), Gaps = 2/250 (0%)
Query: 188 IGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGR 247
I +G +A A + L LD R + A +A AL+I +L L L+ ++
Sbjct: 678 ISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDD 737
Query: 248 PLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLA 307
+A AL N L L+L N + G + ++ + LK N SL+ L +N + D G
Sbjct: 738 GARSMAEALASNRTLSMLHLQKNSI-GPMGAQRMADALKQNRSLKELMFSSNSIGDGGAK 796
Query: 308 YICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLK 367
+ E LK + GL +L L +N ++ G+A L L Q+L +L+L N I EG + +
Sbjct: 797 ALAEALKVNQ-GLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIA 855
Query: 368 NGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALK 427
+ L +N ++ L L + L +GA A+A + E+ L L L+ N I+ G AL AL+
Sbjct: 856 HALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQ 915
Query: 428 VNHSLLRLDL 437
+N SL LDL
Sbjct: 916 LNRSLTSLDL 925
Score = 101 bits (251), Expect = 2e-21
Identities = 94/330 (28%), Positives = 152/330 (46%), Gaps = 17/330 (5%)
Query: 109 LDCLDLKGEKLDYKTCEALEEVFK-RLQFKVVDLEQTNLDEDPRAEAEPPNLYAQGASAL 167
L LDL+G + + +AL + K + L+ + +D GA ++
Sbjct: 696 LTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDD-------------GARSM 742
Query: 168 FDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARA 227
+ + + + L++ N IG G Q A +++ L+ L + + D A +A A
Sbjct: 743 AEALASNRTLSMLHLQKNS-IGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEA 801
Query: 228 LRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKF 287
L++ L L L++ S+S + L AL N L L L +N ++ + + + + L
Sbjct: 802 LKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISP-EGAQAIAHALCA 860
Query: 288 NCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQS 347
N +L+ LDL N + D G I ++E R L +L L N + LG L +S
Sbjct: 861 NSTLKNLDLTANLLHDQGARAIAVAVRENRT-LTSLHLQWNFIQAGAAQALGQALQLNRS 919
Query: 348 LETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRL 407
L +L+L N IG++G + L N ++ L L + GA + E +A + L L
Sbjct: 920 LTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQVLGEALAVNRTLEIL 979
Query: 408 DLRENEIKTGGLMALSLALKVNHSLLRLDL 437
DLR N I G AL+ ALKVN SL RL+L
Sbjct: 980 DLRGNAIGVAGAKALANALKVNSSLRRLNL 1009
Score = 67.4 bits (163), Expect = 4e-11
Identities = 58/198 (29%), Positives = 91/198 (45%), Gaps = 7/198 (3%)
Query: 251 LLATALKMNMNLRELYLADNKLNGLQDSAQ--LGNLLKF-NCSLQILDLRNNHVLDSGLA 307
+L + L + R+L L N+ QD LG++L +C +Q + L N + + G
Sbjct: 628 VLQSLLPQLLYCRKLRLDTNQF---QDPVMELLGSVLSGKDCRIQKISLAENQISNKGAK 684
Query: 308 YICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLK 367
+ L R L +L L N + G L L ++L +L+L N + ++G R +
Sbjct: 685 ALARSLLVNRS-LTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMA 743
Query: 368 NGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALK 427
L SNR++ L L + GA +A+ + ++ L L N I GG AL+ ALK
Sbjct: 744 EALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALK 803
Query: 428 VNHSLLRLDLDREPKKEA 445
VN L LDL +A
Sbjct: 804 VNQGLESLDLQSNSISDA 821
>gi|23503285 leucine rich repeat containing 34 [Homo sapiens]
Length = 419
Score = 85.1 bits (209), Expect = 2e-16
Identities = 68/273 (24%), Positives = 124/273 (45%), Gaps = 12/273 (4%)
Query: 196 AAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATA 255
AA +++K L YL+ + +A+ L +L L + + + M A
Sbjct: 130 AAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAM 189
Query: 256 LKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKE 315
L++N +L +L L D L + + +G +LK N L L + + + +SG+ +C+ L
Sbjct: 190 LQINSSLEKLDLGDCDLE--ESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALY- 246
Query: 316 QRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLIS-NR 374
L L + N++TH GM +L L +LE ++L N I N G +L L S NR
Sbjct: 247 LNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNR 306
Query: 375 SVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLR 434
S+ L + S + EG VA+++ + + + + N+ + S +++
Sbjct: 307 SLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCITYSDLIQMGCL--- 363
Query: 435 LDLDREPKKEAVKSFIETQKALLAEIQNGCKRN 467
+P V+ F+ + LAE+ NG K++
Sbjct: 364 -----KPDNTDVEPFVVDGRVYLAEVSNGLKKH 391
Score = 52.4 bits (124), Expect = 1e-06
Identities = 51/186 (27%), Positives = 85/186 (45%), Gaps = 3/186 (1%)
Query: 252 LATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICE 311
LA + +N+ + ++ G +D L +LK + LD+ N + D G AY
Sbjct: 74 LAAGITLNIAGNNRLVPVERVTG-EDFWILSKILKNCLYINGLDVGYNLLCDVG-AYYAA 131
Query: 312 GLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLI 371
L +++ L+ L L N + G + L ++L+ L + N I N+G L
Sbjct: 132 KLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQ 191
Query: 372 SNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHS 431
N S+ +L L L E V V + E+ L+ L + +++IK G+ L AL +N S
Sbjct: 192 INSSLEKLDLGDCDLE-ESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSS 250
Query: 432 LLRLDL 437
L LD+
Sbjct: 251 LRYLDV 256
Score = 41.6 bits (96), Expect = 0.002
Identities = 48/194 (24%), Positives = 85/194 (43%), Gaps = 3/194 (1%)
Query: 244 LSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLD 303
++G +L+ LK + + L + N L + + LL+ +L L+L N +
Sbjct: 94 VTGEDFWILSKILKNCLYINGLDVGYNLLCDV-GAYYAAKLLQKQLNLIYLNLMFNDIGP 152
Query: 304 SGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGV 363
G I + L + R L L + N++ + G F L SLE L+LG + E
Sbjct: 153 EGGELIAKVLHKNRT-LKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDL-EEST 210
Query: 364 RHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALS 423
H+ L N ++ L + + G + + + + L LD+ N+I G++ L+
Sbjct: 211 VHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLA 270
Query: 424 LALKVNHSLLRLDL 437
LK N +L +DL
Sbjct: 271 DVLKSNTTLEVIDL 284
Score = 38.5 bits (88), Expect = 0.019
Identities = 31/118 (26%), Positives = 53/118 (44%), Gaps = 1/118 (0%)
Query: 328 NQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLT 387
N L G + L +L LNL N IG EG + L NR++ L + K+
Sbjct: 120 NLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIE 179
Query: 388 CEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEA 445
+G + A + + L +LDL + +++ + + LK NH L+ L + + K +
Sbjct: 180 NKGGMFFAAMLQINSSLEKLDLGDCDLEE-STVHVGRMLKENHCLVALHMCKHDIKNS 236
Score = 38.1 bits (87), Expect = 0.024
Identities = 37/134 (27%), Positives = 66/134 (49%), Gaps = 10/134 (7%)
Query: 314 KEQRKGL---VTL-VLWNNQLTH----TGMAF--LGMTLPHTQSLETLNLGHNPIGNEGV 363
+E +KGL +TL + NN+L TG F L L + + L++G+N + + G
Sbjct: 68 EEIKKGLAAGITLNIAGNNRLVPVERVTGEDFWILSKILKNCLYINGLDVGYNLLCDVGA 127
Query: 364 RHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALS 423
+ L +++ L L + EG +A+ + ++ L L + N+I+ G M +
Sbjct: 128 YYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFA 187
Query: 424 LALKVNHSLLRLDL 437
L++N SL +LDL
Sbjct: 188 AMLQINSSLEKLDL 201
>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
sapiens]
Length = 1043
Score = 75.9 bits (185), Expect = 1e-13
Identities = 92/320 (28%), Positives = 132/320 (41%), Gaps = 21/320 (6%)
Query: 112 LDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDEDPRAEAEPPNLYAQGASALFDMI 171
LDL KL + + L K + KV L T P + + QG S L
Sbjct: 731 LDLSNSKLHASSVKGLCLALKNPRCKVQKL--TCKSVTPEWVLQDLIIALQGNSKL---- 784
Query: 172 EYYESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDHSAPFVARALRI 230
THLN S NK T A +R ++C L+YL L S +A L
Sbjct: 785 ------THLNFSSNKLGMTVPLILKA--LRHSACNLKYLCLEKCNLSAASCQDLALFLTS 836
Query: 231 RSSLAVLHLENASLSGRPLMLLATAL---KMNMNLRELYLADNKLNGLQDSAQLGNLLKF 287
+ L L L + LL AL K + EL+ + L + L
Sbjct: 837 IQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACK---HLSDALLQ 893
Query: 288 NCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQS 347
N SL L+L N + D G+ ++CE L L +L L T G L L H +
Sbjct: 894 NRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHN 953
Query: 348 LETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRL 407
++ L+LG N + ++GV+ L L +R++ LGLA LT + ++ S L+ L
Sbjct: 954 VKILDLGENDLQDDGVKLLCEALKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNL 1013
Query: 408 DLRENEIKTGGLMALSLALK 427
+L NE+ T G+ L ALK
Sbjct: 1014 NLLGNELDTDGVKMLCKALK 1033
Score = 53.1 bits (126), Expect = 7e-07
Identities = 65/248 (26%), Positives = 98/248 (39%), Gaps = 4/248 (1%)
Query: 217 LDHSAPFVARALRIRS-SLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGL 275
L + P + +ALR + +L L LE +LS LA L ++ L L N+L
Sbjct: 794 LGMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDD 853
Query: 276 QDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGM 335
L C+L+ L+L + ++ + L + R L L L N L G+
Sbjct: 854 GIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRS-LTHLNLSKNSLRDEGV 912
Query: 336 AFLGMTLPHTQ-SLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAV 394
FL L +L++LNL EG L N L N +V L L L +G +
Sbjct: 913 KFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLL 972
Query: 395 AEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLD-LDREPKKEAVKSFIETQ 453
E + L L L + + T L L + SL+ L+ L E + VK +
Sbjct: 973 CEALKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKAL 1032
Query: 454 KALLAEIQ 461
K +Q
Sbjct: 1033 KKSTCRLQ 1040
>gi|5174617 nucleotide-binding oligomerization domain containing 1
[Homo sapiens]
Length = 953
Score = 73.6 bits (179), Expect = 5e-13
Identities = 56/166 (33%), Positives = 85/166 (51%), Gaps = 4/166 (2%)
Query: 291 LQILDLRNNHVLDSGLAYICEGLKEQRKGLVT-LVLWNNQLTHTGMAFLGMTLPHTQSLE 349
L +L L N + D G+ + E L + + +VT L L+NNQ+T G ++ L + L
Sbjct: 730 LTVLRLSVNQITDGGVKVLSEELTKYK--IVTYLGLYNNQITDVGARYVTKILDECKGLT 787
Query: 350 TLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDL 409
L LG N I +EG ++L + +++S+ +G+ ++ EGA A AE + P L L L
Sbjct: 788 HLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSL 847
Query: 410 RENEIKTGGLMALSLALKVNHSLLRLDL-DREPKKEAVKSFIETQK 454
N I T G +L+ AL+ N SL L L E E +S E K
Sbjct: 848 ASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLK 893
Score = 69.3 bits (168), Expect = 1e-11
Identities = 44/142 (30%), Positives = 76/142 (53%), Gaps = 1/142 (0%)
Query: 294 LDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNL 353
L L NN + D G Y+ + L E KGL L L N++T G +L + + +++S+ + +
Sbjct: 761 LGLYNNQITDVGARYVTKILDEC-KGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGM 819
Query: 354 GHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENE 413
N +G+EG + L ++ S+ L LAS ++ EG ++A + ++ L L L +NE
Sbjct: 820 WGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNE 879
Query: 414 IKTGGLMALSLALKVNHSLLRL 435
+ +L+ LKVN +L L
Sbjct: 880 LNDEVAESLAEMLKVNQTLKHL 901
Score = 60.1 bits (144), Expect = 6e-09
Identities = 58/226 (25%), Positives = 97/226 (42%), Gaps = 2/226 (0%)
Query: 232 SSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSL 291
S L VL L ++ + +L+ L + L L +N++ + + + +L L
Sbjct: 728 SRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDV-GARYVTKILDECKGL 786
Query: 292 QILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETL 351
L L N + G Y+ +K K + + +W NQ+ G L + SL TL
Sbjct: 787 THLKLGKNKITSEGGKYLALAVKNS-KSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTL 845
Query: 352 NLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRE 411
+L N I EG + L L N S+ L L +L E A ++AE + + L L L +
Sbjct: 846 SLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQ 905
Query: 412 NEIKTGGLMALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALL 457
N+I G L+ AL+ N + + L+ K E +K ++
Sbjct: 906 NQITAKGTAQLADALQSNTGITEICLNGNLIKPEEAKVYEDEKRII 951
Score = 46.6 bits (109), Expect = 7e-05
Identities = 32/116 (27%), Positives = 54/116 (46%), Gaps = 1/116 (0%)
Query: 184 FNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENAS 243
+ +G G +A A +R L L + + +ARAL+ +SL +L L
Sbjct: 820 WGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNE 879
Query: 244 LSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNN 299
L+ LA LK+N L+ L+L N++ + +AQL + L+ N + + L N
Sbjct: 880 LNDEVAESLAEMLKVNQTLKHLWLIQNQITA-KGTAQLADALQSNTGITEICLNGN 934
Score = 45.1 bits (105), Expect = 2e-04
Identities = 41/132 (31%), Positives = 62/132 (46%), Gaps = 4/132 (3%)
Query: 321 VTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLG 380
+ L L NN L G+ L P L L L N I + GV+ L L + V LG
Sbjct: 706 LALDLDNNNLNDYGVRELQ---PCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLG 762
Query: 381 LASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDL-DR 439
L + ++T GA V + + E L L L +N+I + G L+LA+K + S+ + +
Sbjct: 763 LYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGN 822
Query: 440 EPKKEAVKSFIE 451
+ E K+F E
Sbjct: 823 QVGDEGAKAFAE 834
>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
Length = 1093
Score = 70.5 bits (171), Expect = 4e-12
Identities = 87/344 (25%), Positives = 148/344 (43%), Gaps = 17/344 (4%)
Query: 112 LDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDEDPRAEAEPPNLYAQGASALFDMI 171
LDLKG + ++L E K + K+ L E NL + + +
Sbjct: 734 LDLKGSDIGDNGVKSLCEALKHPECKLQTLR-----------LESCNLTVFCCLNISNAL 782
Query: 172 EYYESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDHSAPFVARALRI 230
+S LN+S N + G Q +R C L+ L + L + +++ AL
Sbjct: 783 IRSQSLIFLNLSTNNLLDD-GVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALIS 841
Query: 231 RSSLAVLHLENASLSGRPLMLLATALK-MNMNLRELYLADNKLNGLQDSAQLGNLLKFNC 289
L L L + L + L++ AL+ L+ L L L S L L N
Sbjct: 842 NKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLS-SEYLSTSLLHNK 900
Query: 290 SLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLE 349
SL LDL +N + D+G+ +C+ + L L L LT+ L + + +L
Sbjct: 901 SLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLR 960
Query: 350 TLNLGHNPIGNEGVRHLKNGL-ISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLD 408
+L+LG+N + ++GV+ L + L N ++ RLGL LT ++ + + RL++++
Sbjct: 961 SLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMN 1020
Query: 409 LRENEIKTGGLMALSLALKVNHSLLR-LDLDREPKKEAVKSFIE 451
L +N + G++ L LK L+ L L +E E + +E
Sbjct: 1021 LTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLE 1064
Score = 53.1 bits (126), Expect = 7e-07
Identities = 52/201 (25%), Positives = 90/201 (44%), Gaps = 3/201 (1%)
Query: 224 VARALRIRSSLAVLHLENASLSGRPLMLLATALKM-NMNLRELYLADNKLNGLQDSAQLG 282
++ +L +L L L+ + + + L ALK L+ L L L + +
Sbjct: 721 ISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLT-VFCCLNIS 779
Query: 283 NLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTL 342
N L + SL L+L N++LD G+ +CE L+ + L L L + LT G +L + L
Sbjct: 780 NALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLAL 839
Query: 343 PHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLR-LGLASTKLTCEGAVAVAEFIAES 401
+ L L L N +G+ GV+ + + L + L+ L L T + ++ + +
Sbjct: 840 ISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHN 899
Query: 402 PRLLRLDLRENEIKTGGLMAL 422
L LDL N ++ G+ L
Sbjct: 900 KSLTHLDLGSNWLQDNGVKLL 920
Score = 35.0 bits (79), Expect = 0.21
Identities = 40/149 (26%), Positives = 70/149 (46%), Gaps = 4/149 (2%)
Query: 281 LGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHT-GMAFLG 339
L ++L N L+ LDL ++++ S + + L+ L L+L +T G +
Sbjct: 665 LCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLL--KFITFPDGCQDIS 722
Query: 340 MTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLR-LGLASTKLTCEGAVAVAEFI 398
+L H ++L L+L + IG+ GV+ L L L+ L L S LT + ++ +
Sbjct: 723 TSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNAL 782
Query: 399 AESPRLLRLDLRENEIKTGGLMALSLALK 427
S L+ L+L N + G+ L AL+
Sbjct: 783 IRSQSLIFLNLSTNNLLDDGVQLLCEALR 811
>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 70.1 bits (170), Expect = 6e-12
Identities = 71/262 (27%), Positives = 108/262 (41%), Gaps = 58/262 (22%)
Query: 234 LAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLN---------GLQDSAQLGNL 284
L L LE SLS LA+ L+ + +EL +++N +N GL+DS
Sbjct: 144 LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEA 203
Query: 285 LKF--------NC-----------SLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVL 325
LK NC SL+ L L +N + D G+A +C GL L TL +
Sbjct: 204 LKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWI 263
Query: 326 WNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVR--------------------- 364
W +T G L L +SL+ L+L N +G+EG R
Sbjct: 264 WECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSC 323
Query: 365 --------HLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLR-LDLRENEIK 415
H + L NR +L L +++ +L G + + + + +LR L L + ++
Sbjct: 324 SFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVS 383
Query: 416 TGGLMALSLALKVNHSLLRLDL 437
+L+ L NHSL LDL
Sbjct: 384 DSSCSSLAATLLANHSLRELDL 405
Score = 56.6 bits (135), Expect = 7e-08
Identities = 42/148 (28%), Positives = 70/148 (47%), Gaps = 1/148 (0%)
Query: 281 LGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGM 340
+ + L+ N +L L+LR+N + D G+ + +GL+ + L L N LT G L
Sbjct: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
Query: 341 TLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVL-RLGLASTKLTCEGAVAVAEFIA 399
TL +L+ L+L N +G+ G++ L GL+ + L +L L L+ +A +
Sbjct: 108 TLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLR 167
Query: 400 ESPRLLRLDLRENEIKTGGLMALSLALK 427
P L + N+I G+ L LK
Sbjct: 168 AKPDFKELTVSNNDINEAGVRVLCQGLK 195
Score = 50.8 bits (120), Expect = 4e-06
Identities = 60/239 (25%), Positives = 92/239 (38%), Gaps = 29/239 (12%)
Query: 225 ARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNL 284
A L + V+ L++ L+ +++AL++N L EL L N+L + L L
Sbjct: 21 AELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGL 80
Query: 285 LKFNCSLQILDLRN----------------------------NHVLDSGLAYICEGLKEQ 316
+C +Q L L+N N + D+GL +CEGL +
Sbjct: 81 QTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDP 140
Query: 317 RKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSV 376
+ L L L L+ L L + L + +N I GVR L GL +
Sbjct: 141 QCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQ 200
Query: 377 LR-LGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLR 434
L L L S +T + + +A L L L N++ G+ L L S LR
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
Score = 49.3 bits (116), Expect = 1e-05
Identities = 66/278 (23%), Positives = 114/278 (41%), Gaps = 21/278 (7%)
Query: 108 RLDCLDLKGEKLDYKTCEALEEVFK-RLQFKVVDLEQTNLDE-----------DPRAEAE 155
RL+ L L+ L +CE L V + + FK + + +++E D + E
Sbjct: 143 RLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLE 202
Query: 156 PPNLYAQGASA-----LFDMIEYYESATHLNISFNKHIGTRGW-QAAAHMMRKTSCLQYL 209
L + G ++ L ++ S L + NK +G G + ++ +S L+ L
Sbjct: 203 ALKLESCGVTSDNCRDLCGIVASKASLRELALGSNK-LGDVGMAELCPGLLHPSSRLRTL 261
Query: 210 DARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLA-TALKMNMNLRELYLA 268
+ + R LR + SL L L L LL T L+ L L++
Sbjct: 262 WIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVK 321
Query: 269 DNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNN 328
S ++L N L L + NN + D+G+ +C+GL + L L L +
Sbjct: 322 SCSFTAACCS-HFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADC 380
Query: 329 QLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHL 366
++ + + L TL SL L+L +N +G+ G+ L
Sbjct: 381 DVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQL 418
Score = 37.0 bits (84), Expect = 0.055
Identities = 43/169 (25%), Positives = 75/169 (44%), Gaps = 4/169 (2%)
Query: 161 AQGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDH 219
A+G L ++ ES L+++ N+ +G G + + + C L+ L ++
Sbjct: 270 AKGCGDLCRVLRAKESLKELSLAGNE-LGDEGARLLCETLLEPGCQLESLWVKSCSFTAA 328
Query: 220 SAPFVARALRIRSSLAVLHLENASLSGRPLMLLATAL-KMNMNLRELYLADNKLNGLQDS 278
+ L L L + N L + L L + LR L+LAD ++ S
Sbjct: 329 CCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCS 388
Query: 279 AQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWN 327
+ LL N SL+ LDL NN + D+G+ + E +++ L LVL++
Sbjct: 389 SLAATLLA-NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYD 436
>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 70.1 bits (170), Expect = 6e-12
Identities = 71/262 (27%), Positives = 108/262 (41%), Gaps = 58/262 (22%)
Query: 234 LAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLN---------GLQDSAQLGNL 284
L L LE SLS LA+ L+ + +EL +++N +N GL+DS
Sbjct: 144 LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEA 203
Query: 285 LKF--------NC-----------SLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVL 325
LK NC SL+ L L +N + D G+A +C GL L TL +
Sbjct: 204 LKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWI 263
Query: 326 WNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVR--------------------- 364
W +T G L L +SL+ L+L N +G+EG R
Sbjct: 264 WECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSC 323
Query: 365 --------HLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLR-LDLRENEIK 415
H + L NR +L L +++ +L G + + + + +LR L L + ++
Sbjct: 324 SFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVS 383
Query: 416 TGGLMALSLALKVNHSLLRLDL 437
+L+ L NHSL LDL
Sbjct: 384 DSSCSSLAATLLANHSLRELDL 405
Score = 56.6 bits (135), Expect = 7e-08
Identities = 42/148 (28%), Positives = 70/148 (47%), Gaps = 1/148 (0%)
Query: 281 LGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGM 340
+ + L+ N +L L+LR+N + D G+ + +GL+ + L L N LT G L
Sbjct: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
Query: 341 TLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVL-RLGLASTKLTCEGAVAVAEFIA 399
TL +L+ L+L N +G+ G++ L GL+ + L +L L L+ +A +
Sbjct: 108 TLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLR 167
Query: 400 ESPRLLRLDLRENEIKTGGLMALSLALK 427
P L + N+I G+ L LK
Sbjct: 168 AKPDFKELTVSNNDINEAGVRVLCQGLK 195
Score = 50.8 bits (120), Expect = 4e-06
Identities = 60/239 (25%), Positives = 92/239 (38%), Gaps = 29/239 (12%)
Query: 225 ARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNL 284
A L + V+ L++ L+ +++AL++N L EL L N+L + L L
Sbjct: 21 AELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGL 80
Query: 285 LKFNCSLQILDLRN----------------------------NHVLDSGLAYICEGLKEQ 316
+C +Q L L+N N + D+GL +CEGL +
Sbjct: 81 QTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDP 140
Query: 317 RKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSV 376
+ L L L L+ L L + L + +N I GVR L GL +
Sbjct: 141 QCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQ 200
Query: 377 LR-LGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLR 434
L L L S +T + + +A L L L N++ G+ L L S LR
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
Score = 49.3 bits (116), Expect = 1e-05
Identities = 66/278 (23%), Positives = 114/278 (41%), Gaps = 21/278 (7%)
Query: 108 RLDCLDLKGEKLDYKTCEALEEVFK-RLQFKVVDLEQTNLDE-----------DPRAEAE 155
RL+ L L+ L +CE L V + + FK + + +++E D + E
Sbjct: 143 RLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLE 202
Query: 156 PPNLYAQGASA-----LFDMIEYYESATHLNISFNKHIGTRGW-QAAAHMMRKTSCLQYL 209
L + G ++ L ++ S L + NK +G G + ++ +S L+ L
Sbjct: 203 ALKLESCGVTSDNCRDLCGIVASKASLRELALGSNK-LGDVGMAELCPGLLHPSSRLRTL 261
Query: 210 DARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLA-TALKMNMNLRELYLA 268
+ + R LR + SL L L L LL T L+ L L++
Sbjct: 262 WIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVK 321
Query: 269 DNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNN 328
S ++L N L L + NN + D+G+ +C+GL + L L L +
Sbjct: 322 SCSFTAACCS-HFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADC 380
Query: 329 QLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHL 366
++ + + L TL SL L+L +N +G+ G+ L
Sbjct: 381 DVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQL 418
Score = 37.0 bits (84), Expect = 0.055
Identities = 43/169 (25%), Positives = 75/169 (44%), Gaps = 4/169 (2%)
Query: 161 AQGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDH 219
A+G L ++ ES L+++ N+ +G G + + + C L+ L ++
Sbjct: 270 AKGCGDLCRVLRAKESLKELSLAGNE-LGDEGARLLCETLLEPGCQLESLWVKSCSFTAA 328
Query: 220 SAPFVARALRIRSSLAVLHLENASLSGRPLMLLATAL-KMNMNLRELYLADNKLNGLQDS 278
+ L L L + N L + L L + LR L+LAD ++ S
Sbjct: 329 CCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCS 388
Query: 279 AQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWN 327
+ LL N SL+ LDL NN + D+G+ + E +++ L LVL++
Sbjct: 389 SLAATLLA-NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYD 436
>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 70.1 bits (170), Expect = 6e-12
Identities = 71/262 (27%), Positives = 108/262 (41%), Gaps = 58/262 (22%)
Query: 234 LAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLN---------GLQDSAQLGNL 284
L L LE SLS LA+ L+ + +EL +++N +N GL+DS
Sbjct: 144 LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEA 203
Query: 285 LKF--------NC-----------SLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVL 325
LK NC SL+ L L +N + D G+A +C GL L TL +
Sbjct: 204 LKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWI 263
Query: 326 WNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVR--------------------- 364
W +T G L L +SL+ L+L N +G+EG R
Sbjct: 264 WECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSC 323
Query: 365 --------HLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLR-LDLRENEIK 415
H + L NR +L L +++ +L G + + + + +LR L L + ++
Sbjct: 324 SFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVS 383
Query: 416 TGGLMALSLALKVNHSLLRLDL 437
+L+ L NHSL LDL
Sbjct: 384 DSSCSSLAATLLANHSLRELDL 405
Score = 56.6 bits (135), Expect = 7e-08
Identities = 42/148 (28%), Positives = 70/148 (47%), Gaps = 1/148 (0%)
Query: 281 LGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGM 340
+ + L+ N +L L+LR+N + D G+ + +GL+ + L L N LT G L
Sbjct: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
Query: 341 TLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVL-RLGLASTKLTCEGAVAVAEFIA 399
TL +L+ L+L N +G+ G++ L GL+ + L +L L L+ +A +
Sbjct: 108 TLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLR 167
Query: 400 ESPRLLRLDLRENEIKTGGLMALSLALK 427
P L + N+I G+ L LK
Sbjct: 168 AKPDFKELTVSNNDINEAGVRVLCQGLK 195
Score = 50.8 bits (120), Expect = 4e-06
Identities = 60/239 (25%), Positives = 92/239 (38%), Gaps = 29/239 (12%)
Query: 225 ARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNL 284
A L + V+ L++ L+ +++AL++N L EL L N+L + L L
Sbjct: 21 AELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGL 80
Query: 285 LKFNCSLQILDLRN----------------------------NHVLDSGLAYICEGLKEQ 316
+C +Q L L+N N + D+GL +CEGL +
Sbjct: 81 QTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDP 140
Query: 317 RKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSV 376
+ L L L L+ L L + L + +N I GVR L GL +
Sbjct: 141 QCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQ 200
Query: 377 LR-LGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLR 434
L L L S +T + + +A L L L N++ G+ L L S LR
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
Score = 49.3 bits (116), Expect = 1e-05
Identities = 66/278 (23%), Positives = 114/278 (41%), Gaps = 21/278 (7%)
Query: 108 RLDCLDLKGEKLDYKTCEALEEVFK-RLQFKVVDLEQTNLDE-----------DPRAEAE 155
RL+ L L+ L +CE L V + + FK + + +++E D + E
Sbjct: 143 RLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLE 202
Query: 156 PPNLYAQGASA-----LFDMIEYYESATHLNISFNKHIGTRGW-QAAAHMMRKTSCLQYL 209
L + G ++ L ++ S L + NK +G G + ++ +S L+ L
Sbjct: 203 ALKLESCGVTSDNCRDLCGIVASKASLRELALGSNK-LGDVGMAELCPGLLHPSSRLRTL 261
Query: 210 DARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLA-TALKMNMNLRELYLA 268
+ + R LR + SL L L L LL T L+ L L++
Sbjct: 262 WIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVK 321
Query: 269 DNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNN 328
S ++L N L L + NN + D+G+ +C+GL + L L L +
Sbjct: 322 SCSFTAACCS-HFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADC 380
Query: 329 QLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHL 366
++ + + L TL SL L+L +N +G+ G+ L
Sbjct: 381 DVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQL 418
Score = 37.0 bits (84), Expect = 0.055
Identities = 43/169 (25%), Positives = 75/169 (44%), Gaps = 4/169 (2%)
Query: 161 AQGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDH 219
A+G L ++ ES L+++ N+ +G G + + + C L+ L ++
Sbjct: 270 AKGCGDLCRVLRAKESLKELSLAGNE-LGDEGARLLCETLLEPGCQLESLWVKSCSFTAA 328
Query: 220 SAPFVARALRIRSSLAVLHLENASLSGRPLMLLATAL-KMNMNLRELYLADNKLNGLQDS 278
+ L L L + N L + L L + LR L+LAD ++ S
Sbjct: 329 CCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCS 388
Query: 279 AQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWN 327
+ LL N SL+ LDL NN + D+G+ + E +++ L LVL++
Sbjct: 389 SLAATLLA-NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYD 436
>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 70.1 bits (170), Expect = 6e-12
Identities = 71/262 (27%), Positives = 108/262 (41%), Gaps = 58/262 (22%)
Query: 234 LAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLN---------GLQDSAQLGNL 284
L L LE SLS LA+ L+ + +EL +++N +N GL+DS
Sbjct: 144 LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEA 203
Query: 285 LKF--------NC-----------SLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVL 325
LK NC SL+ L L +N + D G+A +C GL L TL +
Sbjct: 204 LKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWI 263
Query: 326 WNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVR--------------------- 364
W +T G L L +SL+ L+L N +G+EG R
Sbjct: 264 WECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSC 323
Query: 365 --------HLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLR-LDLRENEIK 415
H + L NR +L L +++ +L G + + + + +LR L L + ++
Sbjct: 324 SFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVS 383
Query: 416 TGGLMALSLALKVNHSLLRLDL 437
+L+ L NHSL LDL
Sbjct: 384 DSSCSSLAATLLANHSLRELDL 405
Score = 56.6 bits (135), Expect = 7e-08
Identities = 42/148 (28%), Positives = 70/148 (47%), Gaps = 1/148 (0%)
Query: 281 LGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGM 340
+ + L+ N +L L+LR+N + D G+ + +GL+ + L L N LT G L
Sbjct: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
Query: 341 TLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVL-RLGLASTKLTCEGAVAVAEFIA 399
TL +L+ L+L N +G+ G++ L GL+ + L +L L L+ +A +
Sbjct: 108 TLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLR 167
Query: 400 ESPRLLRLDLRENEIKTGGLMALSLALK 427
P L + N+I G+ L LK
Sbjct: 168 AKPDFKELTVSNNDINEAGVRVLCQGLK 195
Score = 50.8 bits (120), Expect = 4e-06
Identities = 60/239 (25%), Positives = 92/239 (38%), Gaps = 29/239 (12%)
Query: 225 ARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNL 284
A L + V+ L++ L+ +++AL++N L EL L N+L + L L
Sbjct: 21 AELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGL 80
Query: 285 LKFNCSLQILDLRN----------------------------NHVLDSGLAYICEGLKEQ 316
+C +Q L L+N N + D+GL +CEGL +
Sbjct: 81 QTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDP 140
Query: 317 RKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSV 376
+ L L L L+ L L + L + +N I GVR L GL +
Sbjct: 141 QCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQ 200
Query: 377 LR-LGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLR 434
L L L S +T + + +A L L L N++ G+ L L S LR
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
Score = 49.3 bits (116), Expect = 1e-05
Identities = 66/278 (23%), Positives = 114/278 (41%), Gaps = 21/278 (7%)
Query: 108 RLDCLDLKGEKLDYKTCEALEEVFK-RLQFKVVDLEQTNLDE-----------DPRAEAE 155
RL+ L L+ L +CE L V + + FK + + +++E D + E
Sbjct: 143 RLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLE 202
Query: 156 PPNLYAQGASA-----LFDMIEYYESATHLNISFNKHIGTRGW-QAAAHMMRKTSCLQYL 209
L + G ++ L ++ S L + NK +G G + ++ +S L+ L
Sbjct: 203 ALKLESCGVTSDNCRDLCGIVASKASLRELALGSNK-LGDVGMAELCPGLLHPSSRLRTL 261
Query: 210 DARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLA-TALKMNMNLRELYLA 268
+ + R LR + SL L L L LL T L+ L L++
Sbjct: 262 WIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVK 321
Query: 269 DNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNN 328
S ++L N L L + NN + D+G+ +C+GL + L L L +
Sbjct: 322 SCSFTAACCS-HFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADC 380
Query: 329 QLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHL 366
++ + + L TL SL L+L +N +G+ G+ L
Sbjct: 381 DVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQL 418
Score = 37.0 bits (84), Expect = 0.055
Identities = 43/169 (25%), Positives = 75/169 (44%), Gaps = 4/169 (2%)
Query: 161 AQGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDH 219
A+G L ++ ES L+++ N+ +G G + + + C L+ L ++
Sbjct: 270 AKGCGDLCRVLRAKESLKELSLAGNE-LGDEGARLLCETLLEPGCQLESLWVKSCSFTAA 328
Query: 220 SAPFVARALRIRSSLAVLHLENASLSGRPLMLLATAL-KMNMNLRELYLADNKLNGLQDS 278
+ L L L + N L + L L + LR L+LAD ++ S
Sbjct: 329 CCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCS 388
Query: 279 AQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWN 327
+ LL N SL+ LDL NN + D+G+ + E +++ L LVL++
Sbjct: 389 SLAATLLA-NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYD 436
>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 70.1 bits (170), Expect = 6e-12
Identities = 71/262 (27%), Positives = 108/262 (41%), Gaps = 58/262 (22%)
Query: 234 LAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLN---------GLQDSAQLGNL 284
L L LE SLS LA+ L+ + +EL +++N +N GL+DS
Sbjct: 144 LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEA 203
Query: 285 LKF--------NC-----------SLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVL 325
LK NC SL+ L L +N + D G+A +C GL L TL +
Sbjct: 204 LKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWI 263
Query: 326 WNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVR--------------------- 364
W +T G L L +SL+ L+L N +G+EG R
Sbjct: 264 WECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSC 323
Query: 365 --------HLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLR-LDLRENEIK 415
H + L NR +L L +++ +L G + + + + +LR L L + ++
Sbjct: 324 SFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVS 383
Query: 416 TGGLMALSLALKVNHSLLRLDL 437
+L+ L NHSL LDL
Sbjct: 384 DSSCSSLAATLLANHSLRELDL 405
Score = 56.6 bits (135), Expect = 7e-08
Identities = 42/148 (28%), Positives = 70/148 (47%), Gaps = 1/148 (0%)
Query: 281 LGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGM 340
+ + L+ N +L L+LR+N + D G+ + +GL+ + L L N LT G L
Sbjct: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
Query: 341 TLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVL-RLGLASTKLTCEGAVAVAEFIA 399
TL +L+ L+L N +G+ G++ L GL+ + L +L L L+ +A +
Sbjct: 108 TLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLR 167
Query: 400 ESPRLLRLDLRENEIKTGGLMALSLALK 427
P L + N+I G+ L LK
Sbjct: 168 AKPDFKELTVSNNDINEAGVRVLCQGLK 195
Score = 50.8 bits (120), Expect = 4e-06
Identities = 60/239 (25%), Positives = 92/239 (38%), Gaps = 29/239 (12%)
Query: 225 ARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNL 284
A L + V+ L++ L+ +++AL++N L EL L N+L + L L
Sbjct: 21 AELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGL 80
Query: 285 LKFNCSLQILDLRN----------------------------NHVLDSGLAYICEGLKEQ 316
+C +Q L L+N N + D+GL +CEGL +
Sbjct: 81 QTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDP 140
Query: 317 RKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSV 376
+ L L L L+ L L + L + +N I GVR L GL +
Sbjct: 141 QCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQ 200
Query: 377 LR-LGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLR 434
L L L S +T + + +A L L L N++ G+ L L S LR
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
Score = 49.3 bits (116), Expect = 1e-05
Identities = 66/278 (23%), Positives = 114/278 (41%), Gaps = 21/278 (7%)
Query: 108 RLDCLDLKGEKLDYKTCEALEEVFK-RLQFKVVDLEQTNLDE-----------DPRAEAE 155
RL+ L L+ L +CE L V + + FK + + +++E D + E
Sbjct: 143 RLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLE 202
Query: 156 PPNLYAQGASA-----LFDMIEYYESATHLNISFNKHIGTRGW-QAAAHMMRKTSCLQYL 209
L + G ++ L ++ S L + NK +G G + ++ +S L+ L
Sbjct: 203 ALKLESCGVTSDNCRDLCGIVASKASLRELALGSNK-LGDVGMAELCPGLLHPSSRLRTL 261
Query: 210 DARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLA-TALKMNMNLRELYLA 268
+ + R LR + SL L L L LL T L+ L L++
Sbjct: 262 WIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVK 321
Query: 269 DNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNN 328
S ++L N L L + NN + D+G+ +C+GL + L L L +
Sbjct: 322 SCSFTAACCS-HFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADC 380
Query: 329 QLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHL 366
++ + + L TL SL L+L +N +G+ G+ L
Sbjct: 381 DVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQL 418
Score = 37.0 bits (84), Expect = 0.055
Identities = 43/169 (25%), Positives = 75/169 (44%), Gaps = 4/169 (2%)
Query: 161 AQGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDH 219
A+G L ++ ES L+++ N+ +G G + + + C L+ L ++
Sbjct: 270 AKGCGDLCRVLRAKESLKELSLAGNE-LGDEGARLLCETLLEPGCQLESLWVKSCSFTAA 328
Query: 220 SAPFVARALRIRSSLAVLHLENASLSGRPLMLLATAL-KMNMNLRELYLADNKLNGLQDS 278
+ L L L + N L + L L + LR L+LAD ++ S
Sbjct: 329 CCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCS 388
Query: 279 AQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWN 327
+ LL N SL+ LDL NN + D+G+ + E +++ L LVL++
Sbjct: 389 SLAATLLA-NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYD 436
>gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 70.1 bits (170), Expect = 6e-12
Identities = 71/262 (27%), Positives = 108/262 (41%), Gaps = 58/262 (22%)
Query: 234 LAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLN---------GLQDSAQLGNL 284
L L LE SLS LA+ L+ + +EL +++N +N GL+DS
Sbjct: 144 LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEA 203
Query: 285 LKF--------NC-----------SLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVL 325
LK NC SL+ L L +N + D G+A +C GL L TL +
Sbjct: 204 LKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWI 263
Query: 326 WNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVR--------------------- 364
W +T G L L +SL+ L+L N +G+EG R
Sbjct: 264 WECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSC 323
Query: 365 --------HLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLR-LDLRENEIK 415
H + L NR +L L +++ +L G + + + + +LR L L + ++
Sbjct: 324 SFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVS 383
Query: 416 TGGLMALSLALKVNHSLLRLDL 437
+L+ L NHSL LDL
Sbjct: 384 DSSCSSLAATLLANHSLRELDL 405
Score = 56.6 bits (135), Expect = 7e-08
Identities = 42/148 (28%), Positives = 70/148 (47%), Gaps = 1/148 (0%)
Query: 281 LGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGM 340
+ + L+ N +L L+LR+N + D G+ + +GL+ + L L N LT G L
Sbjct: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
Query: 341 TLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVL-RLGLASTKLTCEGAVAVAEFIA 399
TL +L+ L+L N +G+ G++ L GL+ + L +L L L+ +A +
Sbjct: 108 TLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLR 167
Query: 400 ESPRLLRLDLRENEIKTGGLMALSLALK 427
P L + N+I G+ L LK
Sbjct: 168 AKPDFKELTVSNNDINEAGVRVLCQGLK 195
Score = 50.8 bits (120), Expect = 4e-06
Identities = 60/239 (25%), Positives = 92/239 (38%), Gaps = 29/239 (12%)
Query: 225 ARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNL 284
A L + V+ L++ L+ +++AL++N L EL L N+L + L L
Sbjct: 21 AELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGL 80
Query: 285 LKFNCSLQILDLRN----------------------------NHVLDSGLAYICEGLKEQ 316
+C +Q L L+N N + D+GL +CEGL +
Sbjct: 81 QTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDP 140
Query: 317 RKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSV 376
+ L L L L+ L L + L + +N I GVR L GL +
Sbjct: 141 QCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQ 200
Query: 377 LR-LGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLR 434
L L L S +T + + +A L L L N++ G+ L L S LR
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
Score = 49.3 bits (116), Expect = 1e-05
Identities = 66/278 (23%), Positives = 114/278 (41%), Gaps = 21/278 (7%)
Query: 108 RLDCLDLKGEKLDYKTCEALEEVFK-RLQFKVVDLEQTNLDE-----------DPRAEAE 155
RL+ L L+ L +CE L V + + FK + + +++E D + E
Sbjct: 143 RLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLE 202
Query: 156 PPNLYAQGASA-----LFDMIEYYESATHLNISFNKHIGTRGW-QAAAHMMRKTSCLQYL 209
L + G ++ L ++ S L + NK +G G + ++ +S L+ L
Sbjct: 203 ALKLESCGVTSDNCRDLCGIVASKASLRELALGSNK-LGDVGMAELCPGLLHPSSRLRTL 261
Query: 210 DARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLA-TALKMNMNLRELYLA 268
+ + R LR + SL L L L LL T L+ L L++
Sbjct: 262 WIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVK 321
Query: 269 DNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNN 328
S ++L N L L + NN + D+G+ +C+GL + L L L +
Sbjct: 322 SCSFTAACCS-HFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADC 380
Query: 329 QLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHL 366
++ + + L TL SL L+L +N +G+ G+ L
Sbjct: 381 DVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQL 418
Score = 37.0 bits (84), Expect = 0.055
Identities = 43/169 (25%), Positives = 75/169 (44%), Gaps = 4/169 (2%)
Query: 161 AQGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDH 219
A+G L ++ ES L+++ N+ +G G + + + C L+ L ++
Sbjct: 270 AKGCGDLCRVLRAKESLKELSLAGNE-LGDEGARLLCETLLEPGCQLESLWVKSCSFTAA 328
Query: 220 SAPFVARALRIRSSLAVLHLENASLSGRPLMLLATAL-KMNMNLRELYLADNKLNGLQDS 278
+ L L L + N L + L L + LR L+LAD ++ S
Sbjct: 329 CCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCS 388
Query: 279 AQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWN 327
+ LL N SL+ LDL NN + D+G+ + E +++ L LVL++
Sbjct: 389 SLAATLLA-NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYD 436
>gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 70.1 bits (170), Expect = 6e-12
Identities = 71/262 (27%), Positives = 108/262 (41%), Gaps = 58/262 (22%)
Query: 234 LAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLN---------GLQDSAQLGNL 284
L L LE SLS LA+ L+ + +EL +++N +N GL+DS
Sbjct: 144 LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEA 203
Query: 285 LKF--------NC-----------SLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVL 325
LK NC SL+ L L +N + D G+A +C GL L TL +
Sbjct: 204 LKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWI 263
Query: 326 WNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVR--------------------- 364
W +T G L L +SL+ L+L N +G+EG R
Sbjct: 264 WECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSC 323
Query: 365 --------HLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLR-LDLRENEIK 415
H + L NR +L L +++ +L G + + + + +LR L L + ++
Sbjct: 324 SFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVS 383
Query: 416 TGGLMALSLALKVNHSLLRLDL 437
+L+ L NHSL LDL
Sbjct: 384 DSSCSSLAATLLANHSLRELDL 405
Score = 56.6 bits (135), Expect = 7e-08
Identities = 42/148 (28%), Positives = 70/148 (47%), Gaps = 1/148 (0%)
Query: 281 LGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGM 340
+ + L+ N +L L+LR+N + D G+ + +GL+ + L L N LT G L
Sbjct: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
Query: 341 TLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVL-RLGLASTKLTCEGAVAVAEFIA 399
TL +L+ L+L N +G+ G++ L GL+ + L +L L L+ +A +
Sbjct: 108 TLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLR 167
Query: 400 ESPRLLRLDLRENEIKTGGLMALSLALK 427
P L + N+I G+ L LK
Sbjct: 168 AKPDFKELTVSNNDINEAGVRVLCQGLK 195
Score = 50.8 bits (120), Expect = 4e-06
Identities = 60/239 (25%), Positives = 92/239 (38%), Gaps = 29/239 (12%)
Query: 225 ARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNL 284
A L + V+ L++ L+ +++AL++N L EL L N+L + L L
Sbjct: 21 AELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGL 80
Query: 285 LKFNCSLQILDLRN----------------------------NHVLDSGLAYICEGLKEQ 316
+C +Q L L+N N + D+GL +CEGL +
Sbjct: 81 QTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDP 140
Query: 317 RKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSV 376
+ L L L L+ L L + L + +N I GVR L GL +
Sbjct: 141 QCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQ 200
Query: 377 LR-LGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLR 434
L L L S +T + + +A L L L N++ G+ L L S LR
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
Score = 49.3 bits (116), Expect = 1e-05
Identities = 66/278 (23%), Positives = 114/278 (41%), Gaps = 21/278 (7%)
Query: 108 RLDCLDLKGEKLDYKTCEALEEVFK-RLQFKVVDLEQTNLDE-----------DPRAEAE 155
RL+ L L+ L +CE L V + + FK + + +++E D + E
Sbjct: 143 RLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLE 202
Query: 156 PPNLYAQGASA-----LFDMIEYYESATHLNISFNKHIGTRGW-QAAAHMMRKTSCLQYL 209
L + G ++ L ++ S L + NK +G G + ++ +S L+ L
Sbjct: 203 ALKLESCGVTSDNCRDLCGIVASKASLRELALGSNK-LGDVGMAELCPGLLHPSSRLRTL 261
Query: 210 DARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLA-TALKMNMNLRELYLA 268
+ + R LR + SL L L L LL T L+ L L++
Sbjct: 262 WIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVK 321
Query: 269 DNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNN 328
S ++L N L L + NN + D+G+ +C+GL + L L L +
Sbjct: 322 SCSFTAACCS-HFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADC 380
Query: 329 QLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHL 366
++ + + L TL SL L+L +N +G+ G+ L
Sbjct: 381 DVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQL 418
Score = 37.0 bits (84), Expect = 0.055
Identities = 43/169 (25%), Positives = 75/169 (44%), Gaps = 4/169 (2%)
Query: 161 AQGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDH 219
A+G L ++ ES L+++ N+ +G G + + + C L+ L ++
Sbjct: 270 AKGCGDLCRVLRAKESLKELSLAGNE-LGDEGARLLCETLLEPGCQLESLWVKSCSFTAA 328
Query: 220 SAPFVARALRIRSSLAVLHLENASLSGRPLMLLATAL-KMNMNLRELYLADNKLNGLQDS 278
+ L L L + N L + L L + LR L+LAD ++ S
Sbjct: 329 CCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCS 388
Query: 279 AQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWN 327
+ LL N SL+ LDL NN + D+G+ + E +++ L LVL++
Sbjct: 389 SLAATLLA-NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYD 436
>gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens]
Length = 461
Score = 70.1 bits (170), Expect = 6e-12
Identities = 71/262 (27%), Positives = 108/262 (41%), Gaps = 58/262 (22%)
Query: 234 LAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLN---------GLQDSAQLGNL 284
L L LE SLS LA+ L+ + +EL +++N +N GL+DS
Sbjct: 144 LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEA 203
Query: 285 LKF--------NC-----------SLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVL 325
LK NC SL+ L L +N + D G+A +C GL L TL +
Sbjct: 204 LKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWI 263
Query: 326 WNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVR--------------------- 364
W +T G L L +SL+ L+L N +G+EG R
Sbjct: 264 WECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSC 323
Query: 365 --------HLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLR-LDLRENEIK 415
H + L NR +L L +++ +L G + + + + +LR L L + ++
Sbjct: 324 SFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVS 383
Query: 416 TGGLMALSLALKVNHSLLRLDL 437
+L+ L NHSL LDL
Sbjct: 384 DSSCSSLAATLLANHSLRELDL 405
Score = 56.6 bits (135), Expect = 7e-08
Identities = 42/148 (28%), Positives = 70/148 (47%), Gaps = 1/148 (0%)
Query: 281 LGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGM 340
+ + L+ N +L L+LR+N + D G+ + +GL+ + L L N LT G L
Sbjct: 48 ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107
Query: 341 TLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVL-RLGLASTKLTCEGAVAVAEFIA 399
TL +L+ L+L N +G+ G++ L GL+ + L +L L L+ +A +
Sbjct: 108 TLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLR 167
Query: 400 ESPRLLRLDLRENEIKTGGLMALSLALK 427
P L + N+I G+ L LK
Sbjct: 168 AKPDFKELTVSNNDINEAGVRVLCQGLK 195
Score = 50.8 bits (120), Expect = 4e-06
Identities = 60/239 (25%), Positives = 92/239 (38%), Gaps = 29/239 (12%)
Query: 225 ARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNL 284
A L + V+ L++ L+ +++AL++N L EL L N+L + L L
Sbjct: 21 AELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGL 80
Query: 285 LKFNCSLQILDLRN----------------------------NHVLDSGLAYICEGLKEQ 316
+C +Q L L+N N + D+GL +CEGL +
Sbjct: 81 QTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDP 140
Query: 317 RKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSV 376
+ L L L L+ L L + L + +N I GVR L GL +
Sbjct: 141 QCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQ 200
Query: 377 LR-LGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLR 434
L L L S +T + + +A L L L N++ G+ L L S LR
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259
Score = 49.3 bits (116), Expect = 1e-05
Identities = 66/278 (23%), Positives = 114/278 (41%), Gaps = 21/278 (7%)
Query: 108 RLDCLDLKGEKLDYKTCEALEEVFK-RLQFKVVDLEQTNLDE-----------DPRAEAE 155
RL+ L L+ L +CE L V + + FK + + +++E D + E
Sbjct: 143 RLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLE 202
Query: 156 PPNLYAQGASA-----LFDMIEYYESATHLNISFNKHIGTRGW-QAAAHMMRKTSCLQYL 209
L + G ++ L ++ S L + NK +G G + ++ +S L+ L
Sbjct: 203 ALKLESCGVTSDNCRDLCGIVASKASLRELALGSNK-LGDVGMAELCPGLLHPSSRLRTL 261
Query: 210 DARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLA-TALKMNMNLRELYLA 268
+ + R LR + SL L L L LL T L+ L L++
Sbjct: 262 WIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVK 321
Query: 269 DNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNN 328
S ++L N L L + NN + D+G+ +C+GL + L L L +
Sbjct: 322 SCSFTAACCS-HFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADC 380
Query: 329 QLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHL 366
++ + + L TL SL L+L +N +G+ G+ L
Sbjct: 381 DVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQL 418
Score = 37.0 bits (84), Expect = 0.055
Identities = 43/169 (25%), Positives = 75/169 (44%), Gaps = 4/169 (2%)
Query: 161 AQGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDH 219
A+G L ++ ES L+++ N+ +G G + + + C L+ L ++
Sbjct: 270 AKGCGDLCRVLRAKESLKELSLAGNE-LGDEGARLLCETLLEPGCQLESLWVKSCSFTAA 328
Query: 220 SAPFVARALRIRSSLAVLHLENASLSGRPLMLLATAL-KMNMNLRELYLADNKLNGLQDS 278
+ L L L + N L + L L + LR L+LAD ++ S
Sbjct: 329 CCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCS 388
Query: 279 AQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWN 327
+ LL N SL+ LDL NN + D+G+ + E +++ L LVL++
Sbjct: 389 SLAATLLA-NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYD 436
>gi|168986655 hypothetical protein LOC145497 [Homo sapiens]
Length = 488
Score = 69.7 bits (169), Expect = 8e-12
Identities = 63/220 (28%), Positives = 106/220 (48%), Gaps = 5/220 (2%)
Query: 225 ARALRIRSSLAV--LHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLG 282
A A+ + S++AV L LE+ + ++ L L+ N L+E+ +++N L GL+ + +
Sbjct: 124 AIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHL-GLEGARIIS 182
Query: 283 NLLKFNCS-LQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMT 341
+ + N S + L+L N + A +C+ L + + L L +NQ + G LG
Sbjct: 183 DFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQ-IKKLDLSHNQFSDVGGEHLGQM 241
Query: 342 LPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAES 401
L L +L+L N G L NGL N ++ +L L+ E A+A+ E + +
Sbjct: 242 LAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLN 301
Query: 402 PRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREP 441
L+ LD+ N+I G +S L+ N SL L L P
Sbjct: 302 RCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNP 341
Score = 69.3 bits (168), Expect = 1e-11
Identities = 55/201 (27%), Positives = 88/201 (43%), Gaps = 1/201 (0%)
Query: 237 LHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDL 296
++L + L R +A AL NM + +L L DN + + L +L+ N LQ +++
Sbjct: 110 VNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIME-EGVLSLVEMLQENYYLQEMNI 168
Query: 297 RNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHN 356
NNH+ G I + + + +L L N A L L ++ L+L HN
Sbjct: 169 SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
Query: 357 PIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKT 416
+ G HL L N + L L+ GAVA+ + + L +LDL N
Sbjct: 229 QFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGN 288
Query: 417 GGLMALSLALKVNHSLLRLDL 437
+AL L++N L+ LD+
Sbjct: 289 EVALALGEVLRLNRCLVYLDI 309
Score = 68.9 bits (167), Expect = 1e-11
Identities = 69/264 (26%), Positives = 107/264 (40%), Gaps = 38/264 (14%)
Query: 151 RAEAEPPNLYAQGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLD 210
+ E E + +G +L +M++ +NIS N H+G G + + + S
Sbjct: 137 KLELEDNCIMEEGVLSLVEMLQENYYLQEMNIS-NNHLGLEGARIISDFFERNS------ 189
Query: 211 ARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADN 270
SS+ L L LL AL N +++L L+ N
Sbjct: 190 ---------------------SSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
Query: 271 KLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQL 330
+ + + LG +L N L LDL N+ G +C GL+ G VTL + +
Sbjct: 229 QFSDV-GGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLR----GNVTLTKLDLSM 283
Query: 331 THTGMAF---LGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLT 387
G LG L + L L++G N IGNEG + GL SN S+ L L +
Sbjct: 284 NGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPIN 343
Query: 388 CEGAVAVAEFIAESP--RLLRLDL 409
+GA+ + I +P R+ LD+
Sbjct: 344 MDGAILLILAIKRNPKSRMEELDI 367
>gi|21450705 leucine rich repeat containing 45 [Homo sapiens]
Length = 670
Score = 69.7 bits (169), Expect = 8e-12
Identities = 77/262 (29%), Positives = 112/262 (42%), Gaps = 7/262 (2%)
Query: 237 LHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDL 296
L L + LS LL L N LR L L N L A LG LL+ N S+Q L L
Sbjct: 63 LVLSDCMLSEEGATLLLRGLCANTVLRFLDLKGNNLRAAGAEA-LGKLLQQNKSIQSLTL 121
Query: 297 RNNHV--LDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLG 354
N + D A C GL L L L NNQ++H G L + L +L+ L+L
Sbjct: 122 EWNSLGTWDDAFATFCGGLAANG-ALQRLDLRNNQISHKGAEELALALKGNTTLQQLDLR 180
Query: 355 HNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEI 414
N +G G R L N L SNR++ RL LA + + AV + + S L +EN+
Sbjct: 181 WNNVGLLGGRALMNCLPSNRTLWRLDLAGNNIPGDVLRAVEQAMGHSQDRL-TTFQENQA 239
Query: 415 KTGGLMALSLALKVNHSLLRLDLDR--EPKKEAVKSFIETQKALLAEIQNGCKRNLVLAR 472
+T L L+ S LDL + ++E + A + ++Q +
Sbjct: 240 RTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIIN 299
Query: 473 EREEKEQPPQLSASMPETTATE 494
+ K Q + + ++ E A +
Sbjct: 300 ALKAKLQMTEAALALSEQKAQD 321
Score = 43.9 bits (102), Expect = 4e-04
Identities = 103/457 (22%), Positives = 172/457 (37%), Gaps = 95/457 (20%)
Query: 73 VDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLDYKTCEALEEVFK 132
++E +Y + C++ +L+QL + LDL + L +TC AL ++
Sbjct: 1 MEEFRRSYSRLCRESGAEPQEAVLQQLHQLPR-----GRLDLATQSLTVETCRALGKLLP 55
Query: 133 R--LQFKVVDLEQTNLDEDPRA---------------EAEPPNLYAQGASALFDMIEYYE 175
R L ++V L L E+ + + NL A GA AL +++ +
Sbjct: 56 RETLCTELV-LSDCMLSEEGATLLLRGLCANTVLRFLDLKGNNLRAAGAEALGKLLQQNK 114
Query: 176 SATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLA 235
S L + +N +GT W D A F L +L
Sbjct: 115 SIQSLTLEWNS-LGT--WD-----------------------DAFATFCG-GLAANGALQ 147
Query: 236 VLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILD 295
L L N +S + LA ALK N L++L L N + GL L N L N +L LD
Sbjct: 148 RLDLRNNQISHKGAEELALALKGNTTLQQLDLRWNNV-GLLGGRALMNCLPSNRTLWRLD 206
Query: 296 LRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQS-------- 347
L N++ L + + + + L T N TH L + H +
Sbjct: 207 LAGNNIPGDVLRAVEQAMGHSQDRLTTF-QENQARTHV----LSKEVQHLREEKSKQFLD 261
Query: 348 -LETLNLGHNPIGNEG------VRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAE 400
+ET++ + V L+ L S++ A ++T E A+A++E A+
Sbjct: 262 LMETIDKQREEMAKSSRASAARVGQLQEALNERHSIINALKAKLQMT-EAALALSEQKAQ 320
Query: 401 SPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEI 460
L + ++ A L L+ ++EA E + LL ++
Sbjct: 321 DLGELLATAEQEQLSLSQRQAKELKLE--------------QQEAA----ERESKLLRDL 362
Query: 461 QNGCKRNLVLAREREEKE-----QPPQLSASMPETTA 492
++NL+L + +E E Q QL + E T+
Sbjct: 363 SAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTS 399
>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
Length = 1200
Score = 69.3 bits (168), Expect = 1e-11
Identities = 78/266 (29%), Positives = 123/266 (46%), Gaps = 11/266 (4%)
Query: 176 SATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDHSAPFVARALRIRSSL 234
S L+++ NK + +G + +R + C LQ L + + +A AL SL
Sbjct: 895 SLKSLSLAGNK-VTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSL 953
Query: 235 AVLHLENASLSGRPLMLLATALKM-NMNLRELYLADNKLNGLQDSAQLGNL---LKFNCS 290
L L N SL + LL ++++ + +L+ L L L D+A G L L N
Sbjct: 954 THLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHL----DTAGCGFLALALMGNSW 1009
Query: 291 LQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLET 350
L L L N V D+G+ +CE ++E L L L LT L + ++ L++
Sbjct: 1010 LTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKS 1069
Query: 351 LNLGHNPIGNEGVRHLKNGLISNRSVL-RLGLASTKLTCEGAVAVAEFIAESPRLLRLDL 409
L+L N +G+ GV L GL SVL RLGL + LT + A++ ++ + L L+L
Sbjct: 1070 LDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNL 1129
Query: 410 RENEIKTGGLMALSLALKVNHSLLRL 435
+N G+M L A S L++
Sbjct: 1130 VQNNFSPKGMMKLCSAFACPTSNLQI 1155
Score = 58.9 bits (141), Expect = 1e-08
Identities = 64/228 (28%), Positives = 97/228 (42%), Gaps = 9/228 (3%)
Query: 198 HMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALK 257
H K L + +A+ TP + H V +RS L+L L + + ALK
Sbjct: 807 HPTCKIQTLMFRNAQITPGVQHLWRIVMANRNLRS----LNLGGTHLKEEDVRMACEALK 862
Query: 258 MNMNLRELYLADNKLNGLQDSAQL--GNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKE 315
L E D GL + L +L + SL+ L L N V D G+ + + L+
Sbjct: 863 HPKCLLESLRLD--CCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRV 920
Query: 316 QRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGL-ISNR 374
+ L L+L + +T TG L L +SL L L +N +GNEGV L + + +
Sbjct: 921 SQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHC 980
Query: 375 SVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMAL 422
S+ RL L L G +A + + L L L N ++ G+ L
Sbjct: 981 SLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLL 1028
Score = 50.8 bits (120), Expect = 4e-06
Identities = 56/217 (25%), Positives = 89/217 (41%), Gaps = 39/217 (17%)
Query: 281 LGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGM 340
L ++ N +L+ L+L H+ + + CE LK + L +L L LTH +
Sbjct: 829 LWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQ 888
Query: 341 TLPHTQSLETLNLGHNPIGNEGV-----------------------------RHLKNGLI 371
L + SL++L+L N + ++GV + L + L+
Sbjct: 889 ILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALV 948
Query: 372 SNRSVLRLGLASTKLTCEGAVAVAEFIAESPRL-----LRLDLRENEIKTGGLMALSLAL 426
SNRS+ L L++ L EG + S RL RL L + + T G L+LAL
Sbjct: 949 SNRSLTHLCLSNNSLGNEGV----NLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALAL 1004
Query: 427 KVNHSLLRLDLDREPKKE-AVKSFIETQKALLAEIQN 462
N L L L P ++ VK E + +Q+
Sbjct: 1005 MGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQD 1041
>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
sapiens]
Length = 979
Score = 68.6 bits (166), Expect = 2e-11
Identities = 73/245 (29%), Positives = 110/245 (44%), Gaps = 13/245 (5%)
Query: 167 LFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPL----LDHSAP 222
LF ++ +S T L++S N +G G + ++ C + R L L H
Sbjct: 733 LFSVLSTSQSLTELDLSDNS-LGDPGMRVLCETLQHPGC----NIRRLWLGRCGLSHECC 787
Query: 223 F-VARALRIRSSLAVLHLENASLSGRPLMLLATALK-MNMNLRELYLADNKLNGLQDSAQ 280
F ++ L L L L + +L + LL LK + NL++L+L ++ L + SA
Sbjct: 788 FDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSA- 846
Query: 281 LGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGM 340
L ++L N +L L LR N + D G+ +CEGL L L L N LT L
Sbjct: 847 LSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLST 906
Query: 341 TLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLR-LGLASTKLTCEGAVAVAEFIA 399
L +QSL L+LG+N +G+ GV L +L+ LGL+ E A+
Sbjct: 907 LLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQE 966
Query: 400 ESPRL 404
E P L
Sbjct: 967 EKPEL 971
Score = 39.7 bits (91), Expect = 0.008
Identities = 31/104 (29%), Positives = 52/104 (50%), Gaps = 1/104 (0%)
Query: 325 LWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGL-ISNRSVLRLGLAS 383
L N+ LT + L L +QSL L+L N +G+ G+R L L ++ RL L
Sbjct: 720 LVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGR 779
Query: 384 TKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALK 427
L+ E ++ ++ + +L+ LDL +N + G+ L + LK
Sbjct: 780 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLK 823
>gi|116268109 nucleotide-binding oligomerization domains 27 [Homo
sapiens]
Length = 1866
Score = 68.6 bits (166), Expect = 2e-11
Identities = 77/266 (28%), Positives = 112/266 (42%), Gaps = 11/266 (4%)
Query: 188 IGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGR 247
+ T G A + L+ LD N + + RAL + L L L + L+
Sbjct: 1506 VSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSS 1565
Query: 248 PLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSG-- 305
L LL L L+ L L N + G L L+ SL+ LDL +N + D+G
Sbjct: 1566 TLALLTHRLSQMTCLQSLRLNRNSI-GDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQ 1624
Query: 306 -LAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVR 364
LA I GL E RK + L N ++ G L +L + LE L LG N +G+
Sbjct: 1625 HLATILPGLPELRK----IDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTAL 1680
Query: 365 HLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGL-MALS 423
L L + VL L + L GA+++A+ + SP L + L EN + G L +
Sbjct: 1681 GLAQELPQHLRVLHLPF--SHLGPGGALSLAQALDGSPHLEEISLAENNLAGGVLRFCME 1738
Query: 424 LALKVNHSLLRLDLDREPKKEAVKSF 449
L L L+ +D + K SF
Sbjct: 1739 LPLLRQIDLVSCKIDNQTAKLLTSSF 1764
Score = 61.6 bits (148), Expect = 2e-09
Identities = 66/220 (30%), Positives = 100/220 (45%), Gaps = 4/220 (1%)
Query: 218 DHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQD 277
D S+ + L S L L ++ +S L LA+ L +L EL L++N+ + +
Sbjct: 1480 DASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDE-EG 1538
Query: 278 SAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAF 337
+ L L+ L+ LDL + + S LA + L Q L +L L N + G
Sbjct: 1539 TKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLS-QMTCLQSLRLNRNSIGDVGCCH 1597
Query: 338 LGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEF 397
L L SLE L+L HN IG+ GV+HL L + ++ L+ ++ G V +AE
Sbjct: 1598 LSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAES 1657
Query: 398 IAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDL 437
+ RL L L N + G AL LA ++ L L L
Sbjct: 1658 LVLCRRLEELMLGCNAL--GDPTALGLAQELPQHLRVLHL 1695
Score = 50.4 bits (119), Expect = 5e-06
Identities = 50/190 (26%), Positives = 77/190 (40%), Gaps = 2/190 (1%)
Query: 274 GLQDSAQLGNLLKFNCSLQILDLRNNHVL--DSGLAYICEGLKEQRKGLVTLVLWNNQLT 331
G S +G L++ LQ L L ++ D + + + L L T L ++ ++
Sbjct: 1448 GAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVS 1507
Query: 332 HTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGA 391
G+A L L H LE L+L +N EG + L L + RL L+ L
Sbjct: 1508 TEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTL 1567
Query: 392 VAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEAVKSFIE 451
+ +++ L L L N I G LS AL+ SL LDL +A +
Sbjct: 1568 ALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLA 1627
Query: 452 TQKALLAEIQ 461
T L E++
Sbjct: 1628 TILPGLPELR 1637
Score = 49.3 bits (116), Expect = 1e-05
Identities = 64/269 (23%), Positives = 107/269 (39%), Gaps = 30/269 (11%)
Query: 198 HMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALK 257
H + + +CLQ L + D ++ ALR +SL L L + + + LAT L
Sbjct: 1572 HRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILP 1631
Query: 258 MNMNLRELYLADNKL-------------------------NGLQDSAQLGNLLKFNCSLQ 292
LR++ L+ N + N L D LG + L+
Sbjct: 1632 GLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQELPQHLR 1691
Query: 293 ILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLN 352
+L L +H+ G + + L + L + L N L + F M LP L ++
Sbjct: 1692 VLHLPFSHLGPGGALSLAQAL-DGSPHLEEISLAENNLAGGVLRFC-MELP---LLRQID 1746
Query: 353 LGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLREN 412
L I N+ + L + S ++ + L+ L E A +A+ + + RL R+DL +N
Sbjct: 1747 LVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKN 1806
Query: 413 EIKTGGLMALSLALKVNHSLLRLDLDREP 441
+I G L+ L S+ + L P
Sbjct: 1807 QITALGAWLLAEGLAQGSSIQVIRLWNNP 1835
Score = 45.1 bits (105), Expect = 2e-04
Identities = 67/274 (24%), Positives = 113/274 (41%), Gaps = 20/274 (7%)
Query: 218 DHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQD 277
D A ++R+L L +L L + ++ R + L AL + L+E+ DN+L+ Q
Sbjct: 700 DAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSD-QV 758
Query: 278 SAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAF 337
+ +L L+ LDL +N + S L + R + + Q + F
Sbjct: 759 VLNIVEVLPHLPRLRKLDLSSNSICVSTLLCLA------RVAVTCPTVRMLQAREADLIF 812
Query: 338 LGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEF 397
L P T++ L + ++G R G S LRL +L A A+
Sbjct: 813 L--LSPPTETTAELQRAPDLQESDGQR---KGAQSRSLTLRL--QKCQLQVHDAEALIAL 865
Query: 398 IAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDL-DREPKKEAVKSFIETQKA- 455
+ E P L +DL N+++ G ++ A H +LDL D V + A
Sbjct: 866 LQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSDNGLSVAGVHCVLRAVSAC 925
Query: 456 -LLAEIQNGCKRNLVL---AREREEKEQPPQLSA 485
LAE+ + V+ A+E EE++ P + +A
Sbjct: 926 WTLAELHISLQHKTVIFMFAQEPEEQKGPQERAA 959
Score = 38.9 bits (89), Expect = 0.014
Identities = 43/165 (26%), Positives = 72/165 (43%), Gaps = 24/165 (14%)
Query: 227 ALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNG--LQDSAQLGNL 284
A + L VLHL + L + LA AL + +L E+ LA+N L G L+ +L L
Sbjct: 1683 AQELPQHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLAGGVLRFCMELPLL 1742
Query: 285 LKFNC---------------------SLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTL 323
+ + +L+++ L N + D A + + L + + L +
Sbjct: 1743 RQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGR-LKRV 1801
Query: 324 VLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKN 368
L NQ+T G L L S++ + L +NPI + +HLK+
Sbjct: 1802 DLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPIPCDMAQHLKS 1846
Score = 33.1 bits (74), Expect = 0.79
Identities = 38/166 (22%), Positives = 65/166 (39%), Gaps = 13/166 (7%)
Query: 348 LETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRL 407
+E L+ G+ L L + + LGLA +K+T G + + + P+L +
Sbjct: 688 IENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKEV 747
Query: 408 DLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRN 467
R+N++ ++ + L L +LDL + S + LA + C
Sbjct: 748 SFRDNQLSDQVVLNIVEVLPHLPRLRKLDL-------SSNSICVSTLLCLARVAVTCP-- 798
Query: 468 LVLAREREEKEQPPQLSASMPETTATEPQ--PDDEPAAGVQNGAPS 511
R + +E S P T E Q PD + + G + GA S
Sbjct: 799 --TVRMLQAREADLIFLLSPPTETTAELQRAPDLQESDGQRKGAQS 842
>gi|61175232 hypothetical protein LOC221424 [Homo sapiens]
Length = 316
Score = 66.6 bits (161), Expect = 6e-11
Identities = 64/218 (29%), Positives = 102/218 (46%), Gaps = 6/218 (2%)
Query: 202 KTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRP-LMLLATALKMNM 260
+ + ++ L R L D + RAL +SLA L+L +S + LA AL+ N
Sbjct: 26 RDNAVRLLSLRGCRLCDRDFGRICRALAGATSLAQLNLNLGVVSSPSRIKQLAEALRTNR 85
Query: 261 NLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQ--RK 318
+++ L+L + L A L L + +L LDL + + D + IC L +
Sbjct: 86 SIQSLFLHGSPLTDA-GLALLNPALALHPALVALDLGDCMLGDEAINLICGLLPPDGAKS 144
Query: 319 GLVTLVLWNNQ-LTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVL 377
GL L L N +T G + L + + H+ + LNL +NP+G+ L + S+R++
Sbjct: 145 GLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLE 204
Query: 378 RLGLASTKLTCEGAVAVAEFIAESPRLLR-LDLRENEI 414
L L T LT + A + + + P LR L L EN I
Sbjct: 205 VLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAENSI 242
Score = 40.4 bits (93), Expect = 0.005
Identities = 30/95 (31%), Positives = 45/95 (47%), Gaps = 1/95 (1%)
Query: 180 LNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHL 239
L +S N I +GW A + +S ++ L+ PL DH A +A A+ +L VL L
Sbjct: 149 LTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDL 208
Query: 240 ENASLSGRPLM-LLATALKMNMNLRELYLADNKLN 273
E L+ + LL LR L LA+N ++
Sbjct: 209 EGTGLTNQSAQTLLDMVENYPTALRSLVLAENSIS 243
Score = 31.6 bits (70), Expect = 2.3
Identities = 42/190 (22%), Positives = 73/190 (38%), Gaps = 5/190 (2%)
Query: 176 SATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLA 235
S LN++ + A +R +Q L +PL D + AL + +L
Sbjct: 57 SLAQLNLNLGVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALV 116
Query: 236 VLHLENASLSGRPLMLLATALK---MNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQ 292
L L + L + L+ L L+EL L+ N + ++L + + ++
Sbjct: 117 ALDLGDCMLGDEAINLICGLLPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVR 176
Query: 293 ILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTH-TGMAFLGMTLPHTQSLETL 351
+L+L N + D + + R L L L LT+ + L M + +L +L
Sbjct: 177 VLNLDYNPLGDHVAGMLAVAVASSRT-LEVLDLEGTGLTNQSAQTLLDMVENYPTALRSL 235
Query: 352 NLGHNPIGNE 361
L N I E
Sbjct: 236 VLAENSISPE 245
>gi|11545912 nucleotide-binding oligomerization domain containing 2
[Homo sapiens]
Length = 1040
Score = 65.5 bits (158), Expect = 1e-10
Identities = 56/175 (32%), Positives = 83/175 (47%), Gaps = 2/175 (1%)
Query: 263 RELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVT 322
+ LYL DN ++ + +L LQ L L NN + D G A+ L R+ +
Sbjct: 818 KALYLRDNNISD-RGICKLIECALHCEQLQKLALFNNKLTD-GCAHSMAKLLACRQNFLA 875
Query: 323 LVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLA 382
L L NN +T G L L SL+ L N +G+EG + L L ++S+ L L
Sbjct: 876 LRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLV 935
Query: 383 STKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDL 437
+ GA A+A +A++ L L L EN ++ G+ +L+ LK N SL L L
Sbjct: 936 GNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKL 990
Score = 62.4 bits (150), Expect = 1e-09
Identities = 61/200 (30%), Positives = 92/200 (46%), Gaps = 4/200 (2%)
Query: 237 LHLENASLSGRPLMLLATALKMNMNLRELYLADNKL-NGLQDSAQLGNLLKFNCSLQILD 295
L+L + ++S R + L L++L L +NKL +G S + LL + L
Sbjct: 820 LYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHS--MAKLLACRQNFLALR 877
Query: 296 LRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGH 355
L NN++ +G + EGL+ L L W N++ G L L QSL L+L
Sbjct: 878 LGNNYITAAGAQVLAEGLRGNTS-LQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVG 936
Query: 356 NPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIK 415
N IG+ G + L L N + L L L EG ++AE + ++ L L L N I
Sbjct: 937 NNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCIT 996
Query: 416 TGGLMALSLALKVNHSLLRL 435
G AL AL+ N ++L +
Sbjct: 997 YLGAEALLQALERNDTILEV 1016
Score = 60.1 bits (144), Expect = 6e-09
Identities = 56/176 (31%), Positives = 81/176 (46%), Gaps = 6/176 (3%)
Query: 294 LDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNL 353
L LR+N++ D G+ + E + L L L+NN+LT + L Q+ L L
Sbjct: 820 LYLRDNNISDRGICKLIECALHCEQ-LQKLALFNNKLTDGCAHSMAKLLACRQNFLALRL 878
Query: 354 GHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENE 413
G+N I G + L GL N S+ LG ++ EGA A+AE + + L L L N
Sbjct: 879 GNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNN 938
Query: 414 IKTGGLMALSLALKVNHSLLRLDLDREP-KKEAVKSFIETQK----ALLAEIQNGC 464
I + G AL+L L N L L L+ + E V S E K + ++ N C
Sbjct: 939 IGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNC 994
>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
Length = 1062
Score = 65.5 bits (158), Expect = 1e-10
Identities = 69/252 (27%), Positives = 110/252 (43%), Gaps = 40/252 (15%)
Query: 218 DHSAPFVARALRI-RSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQ 276
D P + LR +L L L + S + + L+ AL++N +L + L+DN+L L
Sbjct: 768 DDMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNEL--LD 825
Query: 277 DSAQL--GNLLKFNCSLQILDLRNNHVLD----------------------------SGL 306
+ A+L L C LQ L L N H+ + +G+
Sbjct: 826 EGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGV 885
Query: 307 AYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRH- 365
++CEGL+ L TLVLWN +T G L L SL L+LG N IG +G++
Sbjct: 886 KFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFL 945
Query: 366 ---LKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMAL 422
L+ L + R + G + +CE + ++ + L+ LDL +N + + G+ L
Sbjct: 946 CEALRKPLCNLRCLWLWGCSIPPFSCED---LCSALSCNQSLVTLDLGQNPLGSSGVKML 1002
Query: 423 SLALKVNHSLLR 434
L + LR
Sbjct: 1003 FETLTCSSGTLR 1014
Score = 65.5 bits (158), Expect = 1e-10
Identities = 61/212 (28%), Positives = 92/212 (43%), Gaps = 8/212 (3%)
Query: 171 IEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDHSAPFVARALR 229
+E +S T +N+S N+ + G + +R C LQ L N L + + +A L
Sbjct: 807 LEVNQSLTCVNLSDNELLD-EGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLV 865
Query: 230 IRSSLAVLHLENASLSGRPLMLLATALKM---NMNLRELYLADNKLNGLQDSAQLGNLLK 286
+ L L L + + L L+ + L+ D +G D L LL+
Sbjct: 866 VSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCD---LTKLLQ 922
Query: 287 FNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQ 346
SL LDL NH+ G+ ++CE L++ L L LW + L L Q
Sbjct: 923 EKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQ 982
Query: 347 SLETLNLGHNPIGNEGVRHLKNGLISNRSVLR 378
SL TL+LG NP+G+ GV+ L L + LR
Sbjct: 983 SLVTLDLGQNPLGSSGVKMLFETLTCSSGTLR 1014
>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
sapiens]
Length = 1061
Score = 63.5 bits (153), Expect = 5e-10
Identities = 73/258 (28%), Positives = 111/258 (43%), Gaps = 12/258 (4%)
Query: 184 FNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENA 242
+ +G+RG + +R +C LQ L + + + ++ AL +L + L
Sbjct: 721 YRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGN 780
Query: 243 SLSGRPLMLLATALKM-NMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHV 301
+ +MLL L+ L+ + L +L ++ ++L N L LDL N +
Sbjct: 781 GVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLES-GACQEMASVLGTNPHLVELDLTGNAL 839
Query: 302 LDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNE 361
D GL +C+GL+ L TL L +LT L TL QSL L+L N +G+
Sbjct: 840 EDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDL 899
Query: 362 GVRHLKNGL---ISNRSVLRLGLAST-KLTCEGAVAVAEFIAESPRLLRLDLRENEIKTG 417
GV L GL LRLG+ CEG V + + L LDL N++
Sbjct: 900 GVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVV---LQANHNLRELDLSFNDLGDW 956
Query: 418 GLMALSLALKVNHSLLRL 435
GL L+ L+ H RL
Sbjct: 957 GLWLLAEGLQ--HPACRL 972
Score = 44.3 bits (103), Expect = 3e-04
Identities = 42/159 (26%), Positives = 70/159 (44%), Gaps = 3/159 (1%)
Query: 278 SAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAF 337
S L L N +L L L N + G+ +C+GL+ L L L +++ +
Sbjct: 702 SEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACED 761
Query: 338 LGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLR-LGLASTKLTCEGAVAVAE 396
L L ++L ++L N +G G+ L GL + L+ + L +L +A
Sbjct: 762 LSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMAS 821
Query: 397 FIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRL 435
+ +P L+ LDL N ++ GL L L+ H + RL
Sbjct: 822 VLGTNPHLVELDLTGNALEDLGLRLLCQGLR--HPVCRL 858
Score = 43.5 bits (101), Expect = 6e-04
Identities = 47/144 (32%), Positives = 66/144 (45%), Gaps = 2/144 (1%)
Query: 224 VARALRIRSSLAVLHLENASLSGRPLMLLATALKM-NMNLRELYLADNKLNGLQDSAQLG 282
+A L + SL L L L ++LL L+ L+ L L +L G L
Sbjct: 876 LASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRL-GSAACEGLS 934
Query: 283 NLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTL 342
+L+ N +L+ LDL N + D GL + EGL+ L L L + LT L TL
Sbjct: 935 VVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTL 994
Query: 343 PHTQSLETLNLGHNPIGNEGVRHL 366
Q+L L L +N +G+ GVR L
Sbjct: 995 GINQTLTDLYLTNNALGDTGVRLL 1018
Score = 36.6 bits (83), Expect = 0.071
Identities = 52/193 (26%), Positives = 82/193 (42%), Gaps = 11/193 (5%)
Query: 159 LYAQGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLL 217
L A L + +S L++S N+ +G G +R +C LQ L L
Sbjct: 868 LTAAACDELASTLSVNQSLRELDLSLNE-LGDLGVLLLCEGLRHPTCKLQTLRLGICRLG 926
Query: 218 DHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALKMNM-NLRELYLADNKLNGLQ 276
+ ++ L+ +L L L L L LLA L+ L++L+L L +
Sbjct: 927 SAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTA-K 985
Query: 277 DSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLW-----NNQLT 331
L L N +L L L NN + D+G+ +C+ L G VLW N++T
Sbjct: 986 ACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRL--SHPGCKLRVLWLFGMDLNKMT 1043
Query: 332 HTGMAFLGMTLPH 344
H+ +A L +T P+
Sbjct: 1044 HSRLAALRVTKPY 1056
>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
sapiens]
Length = 922
Score = 63.2 bits (152), Expect = 7e-10
Identities = 61/191 (31%), Positives = 88/191 (46%), Gaps = 4/191 (2%)
Query: 217 LDHSAPF-VARALRIRSSLAVLHLENASLSGRPLMLLATALK-MNMNLRELYLADNKLNG 274
L H F ++ L L L L + +L + LL LK + NL++L+L ++ L
Sbjct: 725 LSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTS 784
Query: 275 LQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTG 334
+ SA L ++L N +L L LR N + D G+ +CEGL L L L N LT
Sbjct: 785 VCCSA-LSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHC 843
Query: 335 MAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLR-LGLASTKLTCEGAVA 393
L L +QSL L+LG+N +G+ GV L +L+ LGL+ E A
Sbjct: 844 CWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSA 903
Query: 394 VAEFIAESPRL 404
+ E P L
Sbjct: 904 LETLQEEKPEL 914
>gi|4506411 Ran GTPase activating protein 1 [Homo sapiens]
Length = 587
Score = 63.2 bits (152), Expect = 7e-10
Identities = 68/265 (25%), Positives = 105/265 (39%), Gaps = 40/265 (15%)
Query: 328 NQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLT 387
N + H G+ L L +NL N +G + L + R V + +
Sbjct: 218 NGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVR 277
Query: 388 CEGAVAVAEFIAES-PRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEAV 446
+GAVA+A+ I P+L L+L EIK +A++ A+ L +LDL+
Sbjct: 278 SKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGN------ 331
Query: 447 KSFIETQKALLAEIQNGCKRNLVLAREREEKEQPPQLSASMPETTATEPQPDDEPAAGVQ 506
+ E L E+ G VLA +++++ + E A E + +DE
Sbjct: 332 -TLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDE------ 384
Query: 507 NGAPSPAPSPDSDSDSDSDGEEEEEEE------GERDETPSGAIDTRDTGSSEP---QPP 557
+ + + EEEEEEE GE+ TPS I +TG P PP
Sbjct: 385 --------------EEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNTGEPAPVLSSPP 430
Query: 558 PEPPRSGPPLPNGLKPEFALALPPE 582
P + P+ PE L L P+
Sbjct: 431 PADVSTFLAFPS---PEKLLRLGPK 452
Score = 53.1 bits (126), Expect = 7e-07
Identities = 88/388 (22%), Positives = 146/388 (37%), Gaps = 46/388 (11%)
Query: 233 SLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSA-----QLGN-LLK 286
SL L LE ++ ++A AL+ L+ + +D L+ LG L+
Sbjct: 50 SLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRTEIPPALISLGEGLIT 109
Query: 287 FNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLG------- 339
L LDL +N G+ +G + K L +L + GM G
Sbjct: 110 AGAQLVELDLSDNAFGPDGV----QGFEALLKSSACFTLQELKLNNCGMGIGGGKILAAA 165
Query: 340 MTLPHTQS--------LETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGA 391
+T H +S L+ G N + N+G L ++ + + + G
Sbjct: 166 LTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGI 225
Query: 392 VAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLD----LDREPKKEAVK 447
A+A+ A +P L ++L +N G +A++ LK + ++ L R A+
Sbjct: 226 TALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIA 285
Query: 448 SFIETQKALLAEIQNG---CKRNLVLA-----REREEKEQPPQLSASMPETTATEPQPDD 499
I L E+ KR+ LA ++ E E+ ++ E + Q
Sbjct: 286 DAIRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQ--- 342
Query: 500 EPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEE-EGERDETPSGAIDTRDTGSSEPQPPP 558
E G + S D D + + +GEEEEEE E E +E + + EPQ
Sbjct: 343 EVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRG 402
Query: 559 EPPRSGPPL-----PNGLKPEFALALPP 581
+ +S P PN +P L+ PP
Sbjct: 403 QGEKSATPSRKILDPNTGEPAPVLSSPP 430
Score = 39.3 bits (90), Expect = 0.011
Identities = 37/169 (21%), Positives = 68/169 (40%), Gaps = 1/169 (0%)
Query: 202 KTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMN 261
K L+ A L + A +A A R+ +L +H+ ++ + LA A +N
Sbjct: 178 KPLALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPL 237
Query: 262 LRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLV 321
LR + L DN + + + LK +++++ + V G I + ++ L
Sbjct: 238 LRVINLNDNTFTE-KGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLK 296
Query: 322 TLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGL 370
L L ++ + + LE L+L N +G EG L+ L
Sbjct: 297 ELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVL 345
>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
Length = 991
Score = 61.6 bits (148), Expect = 2e-09
Identities = 82/317 (25%), Positives = 128/317 (40%), Gaps = 22/317 (6%)
Query: 111 CLDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDEDP-----RAEAEP--------- 156
C+ EKL Y E F+++D+E T+LD+ +A A+P
Sbjct: 608 CISDYNEKLVYWR-ELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIF 666
Query: 157 PNLYAQGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTP 215
++Y S LF + + L++ + + + ++ C ++ L
Sbjct: 667 TSVYFGHDSELFKAVLHNPHLKLLSL-YGTSLSQSDIRHLCETLKHPMCKIEELILGKCD 725
Query: 216 LLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALK-MNMNLRELYLADNKLNG 274
+ +A L S L L L L + LL ALK + L L L L
Sbjct: 726 ISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTS 785
Query: 275 LQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTG 334
+ + + +L + SL +LDL +N + D+G+A +C LK + L L LT
Sbjct: 786 VSCDS-ISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDS 844
Query: 335 MAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLR-LGLASTKLT--CEGA 391
+ L L+TL LGHN IG+ GVR L L L LGL + +T C
Sbjct: 845 CKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDD 904
Query: 392 VAVAEFIAESPRLLRLD 408
+A A ++ R L LD
Sbjct: 905 IAAALIACKTLRSLNLD 921
Score = 55.5 bits (132), Expect = 1e-07
Identities = 52/194 (26%), Positives = 85/194 (43%), Gaps = 5/194 (2%)
Query: 236 VLHLENASLSGRPLMLLATALKMNM-NLRELYLADNKLNGLQDSAQLGNLLKFNCSLQIL 294
+L +EN SL L +L AL + LR+L ++L + N L++L
Sbjct: 634 ILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFG---HDSELFKAVLHNPHLKLL 690
Query: 295 DLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLG 354
L + S + ++CE LK + L+L ++ + L L+ L+L
Sbjct: 691 SLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLV 750
Query: 355 HNPIGNEGVRHLKNGLISNRSVL-RLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENE 413
NP+ +EG+ L L + L RL L LT +++E + S L LDL N
Sbjct: 751 ENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNA 810
Query: 414 IKTGGLMALSLALK 427
++ G+ +L ALK
Sbjct: 811 LEDNGVASLCAALK 824
>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
2 [Homo sapiens]
Length = 980
Score = 60.1 bits (144), Expect = 6e-09
Identities = 74/266 (27%), Positives = 111/266 (41%), Gaps = 17/266 (6%)
Query: 198 HMMRKTSCLQYLDARN----TPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLA 253
H+ R T LQ ++ +N T D F+ + +LA H+E R +ML+
Sbjct: 698 HVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAG-HIEWE----RTMMLML 752
Query: 254 TALKMNMNLRELYLADNKLNGL----QDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYI 309
L N YL +L G + A+ +LK N SL+ L L N +LD G +
Sbjct: 753 CDLLRNHKCNLQYL---RLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLL 809
Query: 310 CEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNG 369
+ + + L L L N +LT L L ++ L L L NPIG+ GV+ L G
Sbjct: 810 YKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEG 869
Query: 370 L-ISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKV 428
L + + L L +T G ++E + E+ L LDL N+I G +
Sbjct: 870 LSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIARGLWILCQALENP 929
Query: 429 NHSLLRLDLDREPKKEAVKSFIETQK 454
N +L L L +K +E K
Sbjct: 930 NCNLKHLRLKTYETNLEIKKLLEEVK 955
>gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Homo
sapiens]
Length = 287
Score = 59.3 bits (142), Expect = 1e-08
Identities = 60/194 (30%), Positives = 87/194 (44%), Gaps = 4/194 (2%)
Query: 175 ESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDHSAPFVARALRIRSS 233
++ T +++S N +G G +R C LQ + R L + +A L
Sbjct: 53 KNLTRMDLSGNG-VGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPH 111
Query: 234 LAVLHLENASLSGRPLMLLATALKMNM-NLRELYLADNKLNGLQDSAQLGNLLKFNCSLQ 292
L L L +L L LL L+ + LR L+L +L +L + L N SL+
Sbjct: 112 LVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACD-ELASTLSVNQSLR 170
Query: 293 ILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLN 352
LDL N + D G+ +CEGL+ L TL L + LT L TL Q+L L
Sbjct: 171 ELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFTLGINQTLTDLY 230
Query: 353 LGHNPIGNEGVRHL 366
L +N +G+ GVR L
Sbjct: 231 LTNNALGDTGVRLL 244
Score = 46.6 bits (109), Expect = 7e-05
Identities = 46/144 (31%), Positives = 65/144 (45%), Gaps = 1/144 (0%)
Query: 280 QLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLG 339
++ ++L N L LDL N + D GL +C+GL+ L TL L +LT L
Sbjct: 101 EMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELA 160
Query: 340 MTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLR-LGLASTKLTCEGAVAVAEFI 398
TL QSL L+L N +G+ GV L GL L+ L L S LT + + +
Sbjct: 161 STLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFTL 220
Query: 399 AESPRLLRLDLRENEIKTGGLMAL 422
+ L L L N + G+ L
Sbjct: 221 GINQTLTDLYLTNNALGDTGVRLL 244
Score = 42.4 bits (98), Expect = 0.001
Identities = 41/141 (29%), Positives = 62/141 (43%), Gaps = 1/141 (0%)
Query: 288 NCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQS 347
N +L +DL N V G+ +CEGL+ + L + L QL + L
Sbjct: 52 NKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPH 111
Query: 348 LETLNLGHNPIGNEGVRHLKNGLISNRSVLR-LGLASTKLTCEGAVAVAEFIAESPRLLR 406
L L+L N + + G+R L GL LR L L +LT +A ++ + L
Sbjct: 112 LVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRE 171
Query: 407 LDLRENEIKTGGLMALSLALK 427
LDL NE+ G++ L L+
Sbjct: 172 LDLSLNELGDLGVLLLCEGLR 192
Score = 35.8 bits (81), Expect = 0.12
Identities = 48/185 (25%), Positives = 70/185 (37%), Gaps = 36/185 (19%)
Query: 194 QAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIR-SSLAVLHLENASLSGRPLMLL 252
Q A ++ L LD L D + + LR L L L+ L+ L
Sbjct: 100 QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 159
Query: 253 ATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDL---------------- 296
A+ L +N +LREL L+ N+L L L C LQ L L
Sbjct: 160 ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFT 219
Query: 297 ------------RNNHVLDSGLAYICEGLKEQRKGLVTLVLW-----NNQLTHTGMAFLG 339
NN + D+G+ +C+ L G VLW N++TH+ +A L
Sbjct: 220 LGINQTLTDLYLTNNALGDTGVRLLCKRL--SHPGCKLRVLWLFGMDLNKMTHSRLAALR 277
Query: 340 MTLPH 344
+T P+
Sbjct: 278 VTKPY 282
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.312 0.131 0.378
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,680,927
Number of Sequences: 37866
Number of extensions: 1743758
Number of successful extensions: 28404
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 521
Number of HSP's successfully gapped in prelim test: 1299
Number of HSP's that attempted gapping in prelim test: 15388
Number of HSP's gapped (non-prelim): 9598
length of query: 625
length of database: 18,247,518
effective HSP length: 108
effective length of query: 517
effective length of database: 14,157,990
effective search space: 7319680830
effective search space used: 7319680830
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.