Guide to the Human Genome
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Search of human proteins with 169214345

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|169214345 PREDICTED: leucine rich repeat containing 68 [Homo
sapiens]
         (625 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|169213924 PREDICTED: leucine rich repeat containing 68 [Homo ...  1249   0.0  
gi|169214345 PREDICTED: leucine rich repeat containing 68 [Homo ...  1249   0.0  
gi|169213302 PREDICTED: leucine rich repeat containing 68 [Homo ...  1249   0.0  
gi|118918429 NOD3 protein [Homo sapiens]                              103   5e-22
gi|23503285 leucine rich repeat containing 34 [Homo sapiens]           85   2e-16
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H...    76   1e-13
gi|5174617 nucleotide-binding oligomerization domain containing ...    74   5e-13
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]      70   4e-12
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]           70   6e-12
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]           70   6e-12
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]           70   6e-12
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]           70   6e-12
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]           70   6e-12
gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]           70   6e-12
gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens]           70   6e-12
gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens]           70   6e-12
gi|168986655 hypothetical protein LOC145497 [Homo sapiens]             70   8e-12
gi|21450705 leucine rich repeat containing 45 [Homo sapiens]           70   8e-12
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]    69   1e-11
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho...    69   2e-11
gi|116268109 nucleotide-binding oligomerization domains 27 [Homo...    69   2e-11
gi|61175232 hypothetical protein LOC221424 [Homo sapiens]              67   6e-11
gi|11545912 nucleotide-binding oligomerization domain containing...    65   1e-10
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]        65   1e-10
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho...    64   5e-10
gi|34878690 NLR family, pyrin domain containing 3 isoform b [Hom...    63   7e-10
gi|4506411 Ran GTPase activating protein 1 [Homo sapiens]              63   7e-10
gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]       62   2e-09
gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isof...    60   6e-09
gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Ho...    59   1e-08

>gi|169213924 PREDICTED: leucine rich repeat containing 68 [Homo
           sapiens]
          Length = 625

 Score = 1249 bits (3233), Expect = 0.0
 Identities = 625/625 (100%), Positives = 625/625 (100%)

Query: 1   MEIAPQEAPPVPGADGDIEEAPAEAGSPSPASPPADGRLKAAAKRVTFPSDEDIVSGAVE 60
           MEIAPQEAPPVPGADGDIEEAPAEAGSPSPASPPADGRLKAAAKRVTFPSDEDIVSGAVE
Sbjct: 1   MEIAPQEAPPVPGADGDIEEAPAEAGSPSPASPPADGRLKAAAKRVTFPSDEDIVSGAVE 60

Query: 61  PKDPWRHAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLD 120
           PKDPWRHAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLD
Sbjct: 61  PKDPWRHAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLD 120

Query: 121 YKTCEALEEVFKRLQFKVVDLEQTNLDEDPRAEAEPPNLYAQGASALFDMIEYYESATHL 180
           YKTCEALEEVFKRLQFKVVDLEQTNLDEDPRAEAEPPNLYAQGASALFDMIEYYESATHL
Sbjct: 121 YKTCEALEEVFKRLQFKVVDLEQTNLDEDPRAEAEPPNLYAQGASALFDMIEYYESATHL 180

Query: 181 NISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLE 240
           NISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLE
Sbjct: 181 NISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLE 240

Query: 241 NASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNH 300
           NASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNH
Sbjct: 241 NASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNH 300

Query: 301 VLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGN 360
           VLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGN
Sbjct: 301 VLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGN 360

Query: 361 EGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLM 420
           EGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLM
Sbjct: 361 EGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLM 420

Query: 421 ALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQP 480
           ALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQP
Sbjct: 421 ALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQP 480

Query: 481 PQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEEEGERDETP 540
           PQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEEEGERDETP
Sbjct: 481 PQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEEEGERDETP 540

Query: 541 SGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHEL 600
           SGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHEL
Sbjct: 541 SGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHEL 600

Query: 601 SCSKNEKELEELLLEASQESGQETL 625
           SCSKNEKELEELLLEASQESGQETL
Sbjct: 601 SCSKNEKELEELLLEASQESGQETL 625


>gi|169214345 PREDICTED: leucine rich repeat containing 68 [Homo
           sapiens]
          Length = 625

 Score = 1249 bits (3233), Expect = 0.0
 Identities = 625/625 (100%), Positives = 625/625 (100%)

Query: 1   MEIAPQEAPPVPGADGDIEEAPAEAGSPSPASPPADGRLKAAAKRVTFPSDEDIVSGAVE 60
           MEIAPQEAPPVPGADGDIEEAPAEAGSPSPASPPADGRLKAAAKRVTFPSDEDIVSGAVE
Sbjct: 1   MEIAPQEAPPVPGADGDIEEAPAEAGSPSPASPPADGRLKAAAKRVTFPSDEDIVSGAVE 60

Query: 61  PKDPWRHAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLD 120
           PKDPWRHAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLD
Sbjct: 61  PKDPWRHAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLD 120

Query: 121 YKTCEALEEVFKRLQFKVVDLEQTNLDEDPRAEAEPPNLYAQGASALFDMIEYYESATHL 180
           YKTCEALEEVFKRLQFKVVDLEQTNLDEDPRAEAEPPNLYAQGASALFDMIEYYESATHL
Sbjct: 121 YKTCEALEEVFKRLQFKVVDLEQTNLDEDPRAEAEPPNLYAQGASALFDMIEYYESATHL 180

Query: 181 NISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLE 240
           NISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLE
Sbjct: 181 NISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLE 240

Query: 241 NASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNH 300
           NASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNH
Sbjct: 241 NASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNH 300

Query: 301 VLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGN 360
           VLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGN
Sbjct: 301 VLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGN 360

Query: 361 EGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLM 420
           EGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLM
Sbjct: 361 EGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLM 420

Query: 421 ALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQP 480
           ALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQP
Sbjct: 421 ALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQP 480

Query: 481 PQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEEEGERDETP 540
           PQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEEEGERDETP
Sbjct: 481 PQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEEEGERDETP 540

Query: 541 SGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHEL 600
           SGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHEL
Sbjct: 541 SGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHEL 600

Query: 601 SCSKNEKELEELLLEASQESGQETL 625
           SCSKNEKELEELLLEASQESGQETL
Sbjct: 601 SCSKNEKELEELLLEASQESGQETL 625


>gi|169213302 PREDICTED: leucine rich repeat containing 68 [Homo
           sapiens]
          Length = 625

 Score = 1249 bits (3233), Expect = 0.0
 Identities = 625/625 (100%), Positives = 625/625 (100%)

Query: 1   MEIAPQEAPPVPGADGDIEEAPAEAGSPSPASPPADGRLKAAAKRVTFPSDEDIVSGAVE 60
           MEIAPQEAPPVPGADGDIEEAPAEAGSPSPASPPADGRLKAAAKRVTFPSDEDIVSGAVE
Sbjct: 1   MEIAPQEAPPVPGADGDIEEAPAEAGSPSPASPPADGRLKAAAKRVTFPSDEDIVSGAVE 60

Query: 61  PKDPWRHAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLD 120
           PKDPWRHAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLD
Sbjct: 61  PKDPWRHAQNVTVDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLD 120

Query: 121 YKTCEALEEVFKRLQFKVVDLEQTNLDEDPRAEAEPPNLYAQGASALFDMIEYYESATHL 180
           YKTCEALEEVFKRLQFKVVDLEQTNLDEDPRAEAEPPNLYAQGASALFDMIEYYESATHL
Sbjct: 121 YKTCEALEEVFKRLQFKVVDLEQTNLDEDPRAEAEPPNLYAQGASALFDMIEYYESATHL 180

Query: 181 NISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLE 240
           NISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLE
Sbjct: 181 NISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLE 240

Query: 241 NASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNH 300
           NASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNH
Sbjct: 241 NASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNH 300

Query: 301 VLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGN 360
           VLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGN
Sbjct: 301 VLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGN 360

Query: 361 EGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLM 420
           EGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLM
Sbjct: 361 EGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLM 420

Query: 421 ALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQP 480
           ALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQP
Sbjct: 421 ALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRNLVLAREREEKEQP 480

Query: 481 PQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEEEGERDETP 540
           PQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEEEGERDETP
Sbjct: 481 PQLSASMPETTATEPQPDDEPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEEEGERDETP 540

Query: 541 SGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHEL 600
           SGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHEL
Sbjct: 541 SGAIDTRDTGSSEPQPPPEPPRSGPPLPNGLKPEFALALPPEPPPGPEVKGGSCGLEHEL 600

Query: 601 SCSKNEKELEELLLEASQESGQETL 625
           SCSKNEKELEELLLEASQESGQETL
Sbjct: 601 SCSKNEKELEELLLEASQESGQETL 625


>gi|118918429 NOD3 protein [Homo sapiens]
          Length = 1065

 Score =  103 bits (257), Expect = 5e-22
 Identities = 80/250 (32%), Positives = 125/250 (50%), Gaps = 2/250 (0%)

Query: 188 IGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGR 247
           I  +G +A A  +     L  LD R   +    A  +A AL+I  +L  L L+  ++   
Sbjct: 678 ISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDD 737

Query: 248 PLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLA 307
               +A AL  N  L  L+L  N + G   + ++ + LK N SL+ L   +N + D G  
Sbjct: 738 GARSMAEALASNRTLSMLHLQKNSI-GPMGAQRMADALKQNRSLKELMFSSNSIGDGGAK 796

Query: 308 YICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLK 367
            + E LK  + GL +L L +N ++  G+A L   L   Q+L +L+L  N I  EG + + 
Sbjct: 797 ALAEALKVNQ-GLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIA 855

Query: 368 NGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALK 427
           + L +N ++  L L +  L  +GA A+A  + E+  L  L L+ N I+ G   AL  AL+
Sbjct: 856 HALCANSTLKNLDLTANLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQ 915

Query: 428 VNHSLLRLDL 437
           +N SL  LDL
Sbjct: 916 LNRSLTSLDL 925



 Score =  101 bits (251), Expect = 2e-21
 Identities = 94/330 (28%), Positives = 152/330 (46%), Gaps = 17/330 (5%)

Query: 109  LDCLDLKGEKLDYKTCEALEEVFK-RLQFKVVDLEQTNLDEDPRAEAEPPNLYAQGASAL 167
            L  LDL+G  +  +  +AL +  K       + L+   + +D             GA ++
Sbjct: 696  LTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDD-------------GARSM 742

Query: 168  FDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARA 227
             + +    + + L++  N  IG  G Q  A  +++   L+ L   +  + D  A  +A A
Sbjct: 743  AEALASNRTLSMLHLQKNS-IGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEA 801

Query: 228  LRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKF 287
            L++   L  L L++ S+S   +  L  AL  N  L  L L +N ++  + +  + + L  
Sbjct: 802  LKVNQGLESLDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISP-EGAQAIAHALCA 860

Query: 288  NCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQS 347
            N +L+ LDL  N + D G   I   ++E R  L +L L  N +       LG  L   +S
Sbjct: 861  NSTLKNLDLTANLLHDQGARAIAVAVRENRT-LTSLHLQWNFIQAGAAQALGQALQLNRS 919

Query: 348  LETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRL 407
            L +L+L  N IG++G   +   L  N ++  L L    +   GA  + E +A +  L  L
Sbjct: 920  LTSLDLQENAIGDDGACAVARALKVNTALTALYLQVASIGASGAQVLGEALAVNRTLEIL 979

Query: 408  DLRENEIKTGGLMALSLALKVNHSLLRLDL 437
            DLR N I   G  AL+ ALKVN SL RL+L
Sbjct: 980  DLRGNAIGVAGAKALANALKVNSSLRRLNL 1009



 Score = 67.4 bits (163), Expect = 4e-11
 Identities = 58/198 (29%), Positives = 91/198 (45%), Gaps = 7/198 (3%)

Query: 251 LLATALKMNMNLRELYLADNKLNGLQDSAQ--LGNLLKF-NCSLQILDLRNNHVLDSGLA 307
           +L + L   +  R+L L  N+    QD     LG++L   +C +Q + L  N + + G  
Sbjct: 628 VLQSLLPQLLYCRKLRLDTNQF---QDPVMELLGSVLSGKDCRIQKISLAENQISNKGAK 684

Query: 308 YICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLK 367
            +   L   R  L +L L  N +   G   L   L   ++L +L+L  N + ++G R + 
Sbjct: 685 ALARSLLVNRS-LTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMA 743

Query: 368 NGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALK 427
             L SNR++  L L    +   GA  +A+ + ++  L  L    N I  GG  AL+ ALK
Sbjct: 744 EALASNRTLSMLHLQKNSIGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALK 803

Query: 428 VNHSLLRLDLDREPKKEA 445
           VN  L  LDL      +A
Sbjct: 804 VNQGLESLDLQSNSISDA 821


>gi|23503285 leucine rich repeat containing 34 [Homo sapiens]
          Length = 419

 Score = 85.1 bits (209), Expect = 2e-16
 Identities = 68/273 (24%), Positives = 124/273 (45%), Gaps = 12/273 (4%)

Query: 196 AAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATA 255
           AA +++K   L YL+     +       +A+ L    +L  L +    +  +  M  A  
Sbjct: 130 AAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAM 189

Query: 256 LKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKE 315
           L++N +L +L L D  L   + +  +G +LK N  L  L +  + + +SG+  +C+ L  
Sbjct: 190 LQINSSLEKLDLGDCDLE--ESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALY- 246

Query: 316 QRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLIS-NR 374
               L  L +  N++TH GM +L   L    +LE ++L  N I N G  +L   L S NR
Sbjct: 247 LNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNR 306

Query: 375 SVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLR 434
           S+  L + S  +  EG VA+++ +  +     + +  N+      +  S  +++      
Sbjct: 307 SLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYIWGNKFDEATCITYSDLIQMGCL--- 363

Query: 435 LDLDREPKKEAVKSFIETQKALLAEIQNGCKRN 467
                +P    V+ F+   +  LAE+ NG K++
Sbjct: 364 -----KPDNTDVEPFVVDGRVYLAEVSNGLKKH 391



 Score = 52.4 bits (124), Expect = 1e-06
 Identities = 51/186 (27%), Positives = 85/186 (45%), Gaps = 3/186 (1%)

Query: 252 LATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICE 311
           LA  + +N+      +   ++ G +D   L  +LK    +  LD+  N + D G AY   
Sbjct: 74  LAAGITLNIAGNNRLVPVERVTG-EDFWILSKILKNCLYINGLDVGYNLLCDVG-AYYAA 131

Query: 312 GLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLI 371
            L +++  L+ L L  N +   G   +   L   ++L+ L +  N I N+G       L 
Sbjct: 132 KLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQ 191

Query: 372 SNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHS 431
            N S+ +L L    L  E  V V   + E+  L+ L + +++IK  G+  L  AL +N S
Sbjct: 192 INSSLEKLDLGDCDLE-ESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSS 250

Query: 432 LLRLDL 437
           L  LD+
Sbjct: 251 LRYLDV 256



 Score = 41.6 bits (96), Expect = 0.002
 Identities = 48/194 (24%), Positives = 85/194 (43%), Gaps = 3/194 (1%)

Query: 244 LSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLD 303
           ++G    +L+  LK  + +  L +  N L  +  +     LL+   +L  L+L  N +  
Sbjct: 94  VTGEDFWILSKILKNCLYINGLDVGYNLLCDV-GAYYAAKLLQKQLNLIYLNLMFNDIGP 152

Query: 304 SGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGV 363
            G   I + L + R  L  L +  N++ + G  F    L    SLE L+LG   +  E  
Sbjct: 153 EGGELIAKVLHKNRT-LKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDL-EEST 210

Query: 364 RHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALS 423
            H+   L  N  ++ L +    +   G   + + +  +  L  LD+  N+I   G++ L+
Sbjct: 211 VHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLA 270

Query: 424 LALKVNHSLLRLDL 437
             LK N +L  +DL
Sbjct: 271 DVLKSNTTLEVIDL 284



 Score = 38.5 bits (88), Expect = 0.019
 Identities = 31/118 (26%), Positives = 53/118 (44%), Gaps = 1/118 (0%)

Query: 328 NQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLT 387
           N L   G  +    L    +L  LNL  N IG EG   +   L  NR++  L +   K+ 
Sbjct: 120 NLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIE 179

Query: 388 CEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEA 445
            +G +  A  +  +  L +LDL + +++    + +   LK NH L+ L + +   K +
Sbjct: 180 NKGGMFFAAMLQINSSLEKLDLGDCDLEE-STVHVGRMLKENHCLVALHMCKHDIKNS 236



 Score = 38.1 bits (87), Expect = 0.024
 Identities = 37/134 (27%), Positives = 66/134 (49%), Gaps = 10/134 (7%)

Query: 314 KEQRKGL---VTL-VLWNNQLTH----TGMAF--LGMTLPHTQSLETLNLGHNPIGNEGV 363
           +E +KGL   +TL +  NN+L      TG  F  L   L +   +  L++G+N + + G 
Sbjct: 68  EEIKKGLAAGITLNIAGNNRLVPVERVTGEDFWILSKILKNCLYINGLDVGYNLLCDVGA 127

Query: 364 RHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALS 423
            +    L    +++ L L    +  EG   +A+ + ++  L  L +  N+I+  G M  +
Sbjct: 128 YYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFA 187

Query: 424 LALKVNHSLLRLDL 437
             L++N SL +LDL
Sbjct: 188 AMLQINSSLEKLDL 201


>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
            sapiens]
          Length = 1043

 Score = 75.9 bits (185), Expect = 1e-13
 Identities = 92/320 (28%), Positives = 132/320 (41%), Gaps = 21/320 (6%)

Query: 112  LDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDEDPRAEAEPPNLYAQGASALFDMI 171
            LDL   KL   + + L    K  + KV  L  T     P    +   +  QG S L    
Sbjct: 731  LDLSNSKLHASSVKGLCLALKNPRCKVQKL--TCKSVTPEWVLQDLIIALQGNSKL---- 784

Query: 172  EYYESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDHSAPFVARALRI 230
                  THLN S NK   T      A  +R ++C L+YL      L   S   +A  L  
Sbjct: 785  ------THLNFSSNKLGMTVPLILKA--LRHSACNLKYLCLEKCNLSAASCQDLALFLTS 836

Query: 231  RSSLAVLHLENASLSGRPLMLLATAL---KMNMNLRELYLADNKLNGLQDSAQLGNLLKF 287
               +  L L    L    + LL  AL   K  +   EL+         +    L + L  
Sbjct: 837  IQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLELWFCQLAAPACK---HLSDALLQ 893

Query: 288  NCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQS 347
            N SL  L+L  N + D G+ ++CE L      L +L L     T  G   L   L H  +
Sbjct: 894  NRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHN 953

Query: 348  LETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRL 407
            ++ L+LG N + ++GV+ L   L  +R++  LGLA   LT      +   ++ S  L+ L
Sbjct: 954  VKILDLGENDLQDDGVKLLCEALKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNL 1013

Query: 408  DLRENEIKTGGLMALSLALK 427
            +L  NE+ T G+  L  ALK
Sbjct: 1014 NLLGNELDTDGVKMLCKALK 1033



 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 65/248 (26%), Positives = 98/248 (39%), Gaps = 4/248 (1%)

Query: 217  LDHSAPFVARALRIRS-SLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGL 275
            L  + P + +ALR  + +L  L LE  +LS      LA  L    ++  L L  N+L   
Sbjct: 794  LGMTVPLILKALRHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDD 853

Query: 276  QDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGM 335
                    L    C+L+ L+L    +      ++ + L + R  L  L L  N L   G+
Sbjct: 854  GIKLLCAALTHPKCALERLELWFCQLAAPACKHLSDALLQNRS-LTHLNLSKNSLRDEGV 912

Query: 336  AFLGMTLPHTQ-SLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAV 394
             FL   L     +L++LNL       EG   L N L  N +V  L L    L  +G   +
Sbjct: 913  KFLCEALGRPDGNLQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLL 972

Query: 395  AEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLD-LDREPKKEAVKSFIETQ 453
             E +     L  L L +  + T     L   L  + SL+ L+ L  E   + VK   +  
Sbjct: 973  CEALKPHRALHTLGLAKCNLTTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKAL 1032

Query: 454  KALLAEIQ 461
            K     +Q
Sbjct: 1033 KKSTCRLQ 1040


>gi|5174617 nucleotide-binding oligomerization domain containing 1
           [Homo sapiens]
          Length = 953

 Score = 73.6 bits (179), Expect = 5e-13
 Identities = 56/166 (33%), Positives = 85/166 (51%), Gaps = 4/166 (2%)

Query: 291 LQILDLRNNHVLDSGLAYICEGLKEQRKGLVT-LVLWNNQLTHTGMAFLGMTLPHTQSLE 349
           L +L L  N + D G+  + E L + +  +VT L L+NNQ+T  G  ++   L   + L 
Sbjct: 730 LTVLRLSVNQITDGGVKVLSEELTKYK--IVTYLGLYNNQITDVGARYVTKILDECKGLT 787

Query: 350 TLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDL 409
            L LG N I +EG ++L   + +++S+  +G+   ++  EGA A AE +   P L  L L
Sbjct: 788 HLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSL 847

Query: 410 RENEIKTGGLMALSLALKVNHSLLRLDL-DREPKKEAVKSFIETQK 454
             N I T G  +L+ AL+ N SL  L L   E   E  +S  E  K
Sbjct: 848 ASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLK 893



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 44/142 (30%), Positives = 76/142 (53%), Gaps = 1/142 (0%)

Query: 294 LDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNL 353
           L L NN + D G  Y+ + L E  KGL  L L  N++T  G  +L + + +++S+  + +
Sbjct: 761 LGLYNNQITDVGARYVTKILDEC-KGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGM 819

Query: 354 GHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENE 413
             N +G+EG +     L ++ S+  L LAS  ++ EG  ++A  + ++  L  L L +NE
Sbjct: 820 WGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNE 879

Query: 414 IKTGGLMALSLALKVNHSLLRL 435
           +      +L+  LKVN +L  L
Sbjct: 880 LNDEVAESLAEMLKVNQTLKHL 901



 Score = 60.1 bits (144), Expect = 6e-09
 Identities = 58/226 (25%), Positives = 97/226 (42%), Gaps = 2/226 (0%)

Query: 232 SSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSL 291
           S L VL L    ++   + +L+  L     +  L L +N++  +  +  +  +L     L
Sbjct: 728 SRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDV-GARYVTKILDECKGL 786

Query: 292 QILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETL 351
             L L  N +   G  Y+   +K   K +  + +W NQ+   G       L +  SL TL
Sbjct: 787 THLKLGKNKITSEGGKYLALAVKNS-KSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTL 845

Query: 352 NLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRE 411
           +L  N I  EG + L   L  N S+  L L   +L  E A ++AE +  +  L  L L +
Sbjct: 846 SLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQ 905

Query: 412 NEIKTGGLMALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALL 457
           N+I   G   L+ AL+ N  +  + L+    K       E +K ++
Sbjct: 906 NQITAKGTAQLADALQSNTGITEICLNGNLIKPEEAKVYEDEKRII 951



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 32/116 (27%), Positives = 54/116 (46%), Gaps = 1/116 (0%)

Query: 184 FNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENAS 243
           +   +G  G +A A  +R    L  L   +  +       +ARAL+  +SL +L L    
Sbjct: 820 WGNQVGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNE 879

Query: 244 LSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNN 299
           L+      LA  LK+N  L+ L+L  N++   + +AQL + L+ N  +  + L  N
Sbjct: 880 LNDEVAESLAEMLKVNQTLKHLWLIQNQITA-KGTAQLADALQSNTGITEICLNGN 934



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 41/132 (31%), Positives = 62/132 (46%), Gaps = 4/132 (3%)

Query: 321 VTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLG 380
           + L L NN L   G+  L    P    L  L L  N I + GV+ L   L   + V  LG
Sbjct: 706 LALDLDNNNLNDYGVRELQ---PCFSRLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLG 762

Query: 381 LASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDL-DR 439
           L + ++T  GA  V + + E   L  L L +N+I + G   L+LA+K + S+  + +   
Sbjct: 763 LYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGN 822

Query: 440 EPKKEAVKSFIE 451
           +   E  K+F E
Sbjct: 823 QVGDEGAKAFAE 834


>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
          Length = 1093

 Score = 70.5 bits (171), Expect = 4e-12
 Identities = 87/344 (25%), Positives = 148/344 (43%), Gaps = 17/344 (4%)

Query: 112  LDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDEDPRAEAEPPNLYAQGASALFDMI 171
            LDLKG  +     ++L E  K  + K+  L             E  NL       + + +
Sbjct: 734  LDLKGSDIGDNGVKSLCEALKHPECKLQTLR-----------LESCNLTVFCCLNISNAL 782

Query: 172  EYYESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDHSAPFVARALRI 230
               +S   LN+S N  +   G Q     +R   C L+ L   +  L +    +++ AL  
Sbjct: 783  IRSQSLIFLNLSTNNLLDD-GVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLALIS 841

Query: 231  RSSLAVLHLENASLSGRPLMLLATALK-MNMNLRELYLADNKLNGLQDSAQLGNLLKFNC 289
               L  L L +  L    + L++ AL+     L+ L L       L  S  L   L  N 
Sbjct: 842  NKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLS-SEYLSTSLLHNK 900

Query: 290  SLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLE 349
            SL  LDL +N + D+G+  +C+  +     L  L L    LT+     L   + +  +L 
Sbjct: 901  SLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNNPNLR 960

Query: 350  TLNLGHNPIGNEGVRHLKNGL-ISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLD 408
            +L+LG+N + ++GV+ L + L   N ++ RLGL    LT      ++  +  + RL++++
Sbjct: 961  SLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRLIKMN 1020

Query: 409  LRENEIKTGGLMALSLALKVNHSLLR-LDLDREPKKEAVKSFIE 451
            L +N +   G++ L   LK     L+ L L +E   E  +  +E
Sbjct: 1021 LTQNTLGYEGIVKLYKVLKSPKCKLQVLGLCKEAFDEEAQKLLE 1064



 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 52/201 (25%), Positives = 90/201 (44%), Gaps = 3/201 (1%)

Query: 224 VARALRIRSSLAVLHLENASLSGRPLMLLATALKM-NMNLRELYLADNKLNGLQDSAQLG 282
           ++ +L    +L  L L+ + +    +  L  ALK     L+ L L    L  +     + 
Sbjct: 721 ISTSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLT-VFCCLNIS 779

Query: 283 NLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTL 342
           N L  + SL  L+L  N++LD G+  +CE L+  +  L  L L +  LT  G  +L + L
Sbjct: 780 NALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSLAL 839

Query: 343 PHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLR-LGLASTKLTCEGAVAVAEFIAES 401
              + L  L L  N +G+ GV+ + + L   +  L+ L L     T   +  ++  +  +
Sbjct: 840 ISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSLLHN 899

Query: 402 PRLLRLDLRENEIKTGGLMAL 422
             L  LDL  N ++  G+  L
Sbjct: 900 KSLTHLDLGSNWLQDNGVKLL 920



 Score = 35.0 bits (79), Expect = 0.21
 Identities = 40/149 (26%), Positives = 70/149 (46%), Gaps = 4/149 (2%)

Query: 281 LGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHT-GMAFLG 339
           L ++L  N  L+ LDL ++++  S +  +   L+     L  L+L    +T   G   + 
Sbjct: 665 LCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLL--KFITFPDGCQDIS 722

Query: 340 MTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLR-LGLASTKLTCEGAVAVAEFI 398
            +L H ++L  L+L  + IG+ GV+ L   L      L+ L L S  LT    + ++  +
Sbjct: 723 TSLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNAL 782

Query: 399 AESPRLLRLDLRENEIKTGGLMALSLALK 427
             S  L+ L+L  N +   G+  L  AL+
Sbjct: 783 IRSQSLIFLNLSTNNLLDDGVQLLCEALR 811


>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 71/262 (27%), Positives = 108/262 (41%), Gaps = 58/262 (22%)

Query: 234 LAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLN---------GLQDSAQLGNL 284
           L  L LE  SLS      LA+ L+   + +EL +++N +N         GL+DS      
Sbjct: 144 LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEA 203

Query: 285 LKF--------NC-----------SLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVL 325
           LK         NC           SL+ L L +N + D G+A +C GL      L TL +
Sbjct: 204 LKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWI 263

Query: 326 WNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVR--------------------- 364
           W   +T  G   L   L   +SL+ L+L  N +G+EG R                     
Sbjct: 264 WECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSC 323

Query: 365 --------HLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLR-LDLRENEIK 415
                   H  + L  NR +L L +++ +L   G   + + + +   +LR L L + ++ 
Sbjct: 324 SFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVS 383

Query: 416 TGGLMALSLALKVNHSLLRLDL 437
                +L+  L  NHSL  LDL
Sbjct: 384 DSSCSSLAATLLANHSLRELDL 405



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 42/148 (28%), Positives = 70/148 (47%), Gaps = 1/148 (0%)

Query: 281 LGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGM 340
           + + L+ N +L  L+LR+N + D G+  + +GL+     +  L L N  LT  G   L  
Sbjct: 48  ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107

Query: 341 TLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVL-RLGLASTKLTCEGAVAVAEFIA 399
           TL    +L+ L+L  N +G+ G++ L  GL+  +  L +L L    L+      +A  + 
Sbjct: 108 TLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLR 167

Query: 400 ESPRLLRLDLRENEIKTGGLMALSLALK 427
             P    L +  N+I   G+  L   LK
Sbjct: 168 AKPDFKELTVSNNDINEAGVRVLCQGLK 195



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 60/239 (25%), Positives = 92/239 (38%), Gaps = 29/239 (12%)

Query: 225 ARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNL 284
           A  L +     V+ L++  L+      +++AL++N  L EL L  N+L  +     L  L
Sbjct: 21  AELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGL 80

Query: 285 LKFNCSLQILDLRN----------------------------NHVLDSGLAYICEGLKEQ 316
              +C +Q L L+N                            N + D+GL  +CEGL + 
Sbjct: 81  QTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDP 140

Query: 317 RKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSV 376
           +  L  L L    L+      L   L      + L + +N I   GVR L  GL  +   
Sbjct: 141 QCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQ 200

Query: 377 LR-LGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLR 434
           L  L L S  +T +    +   +A    L  L L  N++   G+  L   L    S LR
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 66/278 (23%), Positives = 114/278 (41%), Gaps = 21/278 (7%)

Query: 108 RLDCLDLKGEKLDYKTCEALEEVFK-RLQFKVVDLEQTNLDE-----------DPRAEAE 155
           RL+ L L+   L   +CE L  V + +  FK + +   +++E           D   + E
Sbjct: 143 RLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLE 202

Query: 156 PPNLYAQGASA-----LFDMIEYYESATHLNISFNKHIGTRGW-QAAAHMMRKTSCLQYL 209
              L + G ++     L  ++    S   L +  NK +G  G  +    ++  +S L+ L
Sbjct: 203 ALKLESCGVTSDNCRDLCGIVASKASLRELALGSNK-LGDVGMAELCPGLLHPSSRLRTL 261

Query: 210 DARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLA-TALKMNMNLRELYLA 268
                 +       + R LR + SL  L L    L      LL  T L+    L  L++ 
Sbjct: 262 WIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVK 321

Query: 269 DNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNN 328
                    S    ++L  N  L  L + NN + D+G+  +C+GL +    L  L L + 
Sbjct: 322 SCSFTAACCS-HFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADC 380

Query: 329 QLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHL 366
            ++ +  + L  TL    SL  L+L +N +G+ G+  L
Sbjct: 381 DVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQL 418



 Score = 37.0 bits (84), Expect = 0.055
 Identities = 43/169 (25%), Positives = 75/169 (44%), Gaps = 4/169 (2%)

Query: 161 AQGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDH 219
           A+G   L  ++   ES   L+++ N+ +G  G +     + +  C L+ L  ++      
Sbjct: 270 AKGCGDLCRVLRAKESLKELSLAGNE-LGDEGARLLCETLLEPGCQLESLWVKSCSFTAA 328

Query: 220 SAPFVARALRIRSSLAVLHLENASLSGRPLMLLATAL-KMNMNLRELYLADNKLNGLQDS 278
                +  L     L  L + N  L    +  L   L +    LR L+LAD  ++    S
Sbjct: 329 CCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCS 388

Query: 279 AQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWN 327
           +    LL  N SL+ LDL NN + D+G+  + E +++    L  LVL++
Sbjct: 389 SLAATLLA-NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYD 436


>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 71/262 (27%), Positives = 108/262 (41%), Gaps = 58/262 (22%)

Query: 234 LAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLN---------GLQDSAQLGNL 284
           L  L LE  SLS      LA+ L+   + +EL +++N +N         GL+DS      
Sbjct: 144 LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEA 203

Query: 285 LKF--------NC-----------SLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVL 325
           LK         NC           SL+ L L +N + D G+A +C GL      L TL +
Sbjct: 204 LKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWI 263

Query: 326 WNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVR--------------------- 364
           W   +T  G   L   L   +SL+ L+L  N +G+EG R                     
Sbjct: 264 WECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSC 323

Query: 365 --------HLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLR-LDLRENEIK 415
                   H  + L  NR +L L +++ +L   G   + + + +   +LR L L + ++ 
Sbjct: 324 SFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVS 383

Query: 416 TGGLMALSLALKVNHSLLRLDL 437
                +L+  L  NHSL  LDL
Sbjct: 384 DSSCSSLAATLLANHSLRELDL 405



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 42/148 (28%), Positives = 70/148 (47%), Gaps = 1/148 (0%)

Query: 281 LGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGM 340
           + + L+ N +L  L+LR+N + D G+  + +GL+     +  L L N  LT  G   L  
Sbjct: 48  ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107

Query: 341 TLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVL-RLGLASTKLTCEGAVAVAEFIA 399
           TL    +L+ L+L  N +G+ G++ L  GL+  +  L +L L    L+      +A  + 
Sbjct: 108 TLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLR 167

Query: 400 ESPRLLRLDLRENEIKTGGLMALSLALK 427
             P    L +  N+I   G+  L   LK
Sbjct: 168 AKPDFKELTVSNNDINEAGVRVLCQGLK 195



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 60/239 (25%), Positives = 92/239 (38%), Gaps = 29/239 (12%)

Query: 225 ARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNL 284
           A  L +     V+ L++  L+      +++AL++N  L EL L  N+L  +     L  L
Sbjct: 21  AELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGL 80

Query: 285 LKFNCSLQILDLRN----------------------------NHVLDSGLAYICEGLKEQ 316
              +C +Q L L+N                            N + D+GL  +CEGL + 
Sbjct: 81  QTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDP 140

Query: 317 RKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSV 376
           +  L  L L    L+      L   L      + L + +N I   GVR L  GL  +   
Sbjct: 141 QCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQ 200

Query: 377 LR-LGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLR 434
           L  L L S  +T +    +   +A    L  L L  N++   G+  L   L    S LR
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 66/278 (23%), Positives = 114/278 (41%), Gaps = 21/278 (7%)

Query: 108 RLDCLDLKGEKLDYKTCEALEEVFK-RLQFKVVDLEQTNLDE-----------DPRAEAE 155
           RL+ L L+   L   +CE L  V + +  FK + +   +++E           D   + E
Sbjct: 143 RLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLE 202

Query: 156 PPNLYAQGASA-----LFDMIEYYESATHLNISFNKHIGTRGW-QAAAHMMRKTSCLQYL 209
              L + G ++     L  ++    S   L +  NK +G  G  +    ++  +S L+ L
Sbjct: 203 ALKLESCGVTSDNCRDLCGIVASKASLRELALGSNK-LGDVGMAELCPGLLHPSSRLRTL 261

Query: 210 DARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLA-TALKMNMNLRELYLA 268
                 +       + R LR + SL  L L    L      LL  T L+    L  L++ 
Sbjct: 262 WIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVK 321

Query: 269 DNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNN 328
                    S    ++L  N  L  L + NN + D+G+  +C+GL +    L  L L + 
Sbjct: 322 SCSFTAACCS-HFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADC 380

Query: 329 QLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHL 366
            ++ +  + L  TL    SL  L+L +N +G+ G+  L
Sbjct: 381 DVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQL 418



 Score = 37.0 bits (84), Expect = 0.055
 Identities = 43/169 (25%), Positives = 75/169 (44%), Gaps = 4/169 (2%)

Query: 161 AQGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDH 219
           A+G   L  ++   ES   L+++ N+ +G  G +     + +  C L+ L  ++      
Sbjct: 270 AKGCGDLCRVLRAKESLKELSLAGNE-LGDEGARLLCETLLEPGCQLESLWVKSCSFTAA 328

Query: 220 SAPFVARALRIRSSLAVLHLENASLSGRPLMLLATAL-KMNMNLRELYLADNKLNGLQDS 278
                +  L     L  L + N  L    +  L   L +    LR L+LAD  ++    S
Sbjct: 329 CCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCS 388

Query: 279 AQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWN 327
           +    LL  N SL+ LDL NN + D+G+  + E +++    L  LVL++
Sbjct: 389 SLAATLLA-NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYD 436


>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 71/262 (27%), Positives = 108/262 (41%), Gaps = 58/262 (22%)

Query: 234 LAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLN---------GLQDSAQLGNL 284
           L  L LE  SLS      LA+ L+   + +EL +++N +N         GL+DS      
Sbjct: 144 LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEA 203

Query: 285 LKF--------NC-----------SLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVL 325
           LK         NC           SL+ L L +N + D G+A +C GL      L TL +
Sbjct: 204 LKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWI 263

Query: 326 WNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVR--------------------- 364
           W   +T  G   L   L   +SL+ L+L  N +G+EG R                     
Sbjct: 264 WECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSC 323

Query: 365 --------HLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLR-LDLRENEIK 415
                   H  + L  NR +L L +++ +L   G   + + + +   +LR L L + ++ 
Sbjct: 324 SFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVS 383

Query: 416 TGGLMALSLALKVNHSLLRLDL 437
                +L+  L  NHSL  LDL
Sbjct: 384 DSSCSSLAATLLANHSLRELDL 405



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 42/148 (28%), Positives = 70/148 (47%), Gaps = 1/148 (0%)

Query: 281 LGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGM 340
           + + L+ N +L  L+LR+N + D G+  + +GL+     +  L L N  LT  G   L  
Sbjct: 48  ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107

Query: 341 TLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVL-RLGLASTKLTCEGAVAVAEFIA 399
           TL    +L+ L+L  N +G+ G++ L  GL+  +  L +L L    L+      +A  + 
Sbjct: 108 TLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLR 167

Query: 400 ESPRLLRLDLRENEIKTGGLMALSLALK 427
             P    L +  N+I   G+  L   LK
Sbjct: 168 AKPDFKELTVSNNDINEAGVRVLCQGLK 195



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 60/239 (25%), Positives = 92/239 (38%), Gaps = 29/239 (12%)

Query: 225 ARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNL 284
           A  L +     V+ L++  L+      +++AL++N  L EL L  N+L  +     L  L
Sbjct: 21  AELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGL 80

Query: 285 LKFNCSLQILDLRN----------------------------NHVLDSGLAYICEGLKEQ 316
              +C +Q L L+N                            N + D+GL  +CEGL + 
Sbjct: 81  QTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDP 140

Query: 317 RKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSV 376
           +  L  L L    L+      L   L      + L + +N I   GVR L  GL  +   
Sbjct: 141 QCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQ 200

Query: 377 LR-LGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLR 434
           L  L L S  +T +    +   +A    L  L L  N++   G+  L   L    S LR
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 66/278 (23%), Positives = 114/278 (41%), Gaps = 21/278 (7%)

Query: 108 RLDCLDLKGEKLDYKTCEALEEVFK-RLQFKVVDLEQTNLDE-----------DPRAEAE 155
           RL+ L L+   L   +CE L  V + +  FK + +   +++E           D   + E
Sbjct: 143 RLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLE 202

Query: 156 PPNLYAQGASA-----LFDMIEYYESATHLNISFNKHIGTRGW-QAAAHMMRKTSCLQYL 209
              L + G ++     L  ++    S   L +  NK +G  G  +    ++  +S L+ L
Sbjct: 203 ALKLESCGVTSDNCRDLCGIVASKASLRELALGSNK-LGDVGMAELCPGLLHPSSRLRTL 261

Query: 210 DARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLA-TALKMNMNLRELYLA 268
                 +       + R LR + SL  L L    L      LL  T L+    L  L++ 
Sbjct: 262 WIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVK 321

Query: 269 DNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNN 328
                    S    ++L  N  L  L + NN + D+G+  +C+GL +    L  L L + 
Sbjct: 322 SCSFTAACCS-HFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADC 380

Query: 329 QLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHL 366
            ++ +  + L  TL    SL  L+L +N +G+ G+  L
Sbjct: 381 DVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQL 418



 Score = 37.0 bits (84), Expect = 0.055
 Identities = 43/169 (25%), Positives = 75/169 (44%), Gaps = 4/169 (2%)

Query: 161 AQGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDH 219
           A+G   L  ++   ES   L+++ N+ +G  G +     + +  C L+ L  ++      
Sbjct: 270 AKGCGDLCRVLRAKESLKELSLAGNE-LGDEGARLLCETLLEPGCQLESLWVKSCSFTAA 328

Query: 220 SAPFVARALRIRSSLAVLHLENASLSGRPLMLLATAL-KMNMNLRELYLADNKLNGLQDS 278
                +  L     L  L + N  L    +  L   L +    LR L+LAD  ++    S
Sbjct: 329 CCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCS 388

Query: 279 AQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWN 327
           +    LL  N SL+ LDL NN + D+G+  + E +++    L  LVL++
Sbjct: 389 SLAATLLA-NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYD 436


>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 71/262 (27%), Positives = 108/262 (41%), Gaps = 58/262 (22%)

Query: 234 LAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLN---------GLQDSAQLGNL 284
           L  L LE  SLS      LA+ L+   + +EL +++N +N         GL+DS      
Sbjct: 144 LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEA 203

Query: 285 LKF--------NC-----------SLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVL 325
           LK         NC           SL+ L L +N + D G+A +C GL      L TL +
Sbjct: 204 LKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWI 263

Query: 326 WNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVR--------------------- 364
           W   +T  G   L   L   +SL+ L+L  N +G+EG R                     
Sbjct: 264 WECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSC 323

Query: 365 --------HLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLR-LDLRENEIK 415
                   H  + L  NR +L L +++ +L   G   + + + +   +LR L L + ++ 
Sbjct: 324 SFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVS 383

Query: 416 TGGLMALSLALKVNHSLLRLDL 437
                +L+  L  NHSL  LDL
Sbjct: 384 DSSCSSLAATLLANHSLRELDL 405



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 42/148 (28%), Positives = 70/148 (47%), Gaps = 1/148 (0%)

Query: 281 LGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGM 340
           + + L+ N +L  L+LR+N + D G+  + +GL+     +  L L N  LT  G   L  
Sbjct: 48  ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107

Query: 341 TLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVL-RLGLASTKLTCEGAVAVAEFIA 399
           TL    +L+ L+L  N +G+ G++ L  GL+  +  L +L L    L+      +A  + 
Sbjct: 108 TLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLR 167

Query: 400 ESPRLLRLDLRENEIKTGGLMALSLALK 427
             P    L +  N+I   G+  L   LK
Sbjct: 168 AKPDFKELTVSNNDINEAGVRVLCQGLK 195



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 60/239 (25%), Positives = 92/239 (38%), Gaps = 29/239 (12%)

Query: 225 ARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNL 284
           A  L +     V+ L++  L+      +++AL++N  L EL L  N+L  +     L  L
Sbjct: 21  AELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGL 80

Query: 285 LKFNCSLQILDLRN----------------------------NHVLDSGLAYICEGLKEQ 316
              +C +Q L L+N                            N + D+GL  +CEGL + 
Sbjct: 81  QTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDP 140

Query: 317 RKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSV 376
           +  L  L L    L+      L   L      + L + +N I   GVR L  GL  +   
Sbjct: 141 QCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQ 200

Query: 377 LR-LGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLR 434
           L  L L S  +T +    +   +A    L  L L  N++   G+  L   L    S LR
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 66/278 (23%), Positives = 114/278 (41%), Gaps = 21/278 (7%)

Query: 108 RLDCLDLKGEKLDYKTCEALEEVFK-RLQFKVVDLEQTNLDE-----------DPRAEAE 155
           RL+ L L+   L   +CE L  V + +  FK + +   +++E           D   + E
Sbjct: 143 RLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLE 202

Query: 156 PPNLYAQGASA-----LFDMIEYYESATHLNISFNKHIGTRGW-QAAAHMMRKTSCLQYL 209
              L + G ++     L  ++    S   L +  NK +G  G  +    ++  +S L+ L
Sbjct: 203 ALKLESCGVTSDNCRDLCGIVASKASLRELALGSNK-LGDVGMAELCPGLLHPSSRLRTL 261

Query: 210 DARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLA-TALKMNMNLRELYLA 268
                 +       + R LR + SL  L L    L      LL  T L+    L  L++ 
Sbjct: 262 WIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVK 321

Query: 269 DNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNN 328
                    S    ++L  N  L  L + NN + D+G+  +C+GL +    L  L L + 
Sbjct: 322 SCSFTAACCS-HFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADC 380

Query: 329 QLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHL 366
            ++ +  + L  TL    SL  L+L +N +G+ G+  L
Sbjct: 381 DVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQL 418



 Score = 37.0 bits (84), Expect = 0.055
 Identities = 43/169 (25%), Positives = 75/169 (44%), Gaps = 4/169 (2%)

Query: 161 AQGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDH 219
           A+G   L  ++   ES   L+++ N+ +G  G +     + +  C L+ L  ++      
Sbjct: 270 AKGCGDLCRVLRAKESLKELSLAGNE-LGDEGARLLCETLLEPGCQLESLWVKSCSFTAA 328

Query: 220 SAPFVARALRIRSSLAVLHLENASLSGRPLMLLATAL-KMNMNLRELYLADNKLNGLQDS 278
                +  L     L  L + N  L    +  L   L +    LR L+LAD  ++    S
Sbjct: 329 CCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCS 388

Query: 279 AQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWN 327
           +    LL  N SL+ LDL NN + D+G+  + E +++    L  LVL++
Sbjct: 389 SLAATLLA-NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYD 436


>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 71/262 (27%), Positives = 108/262 (41%), Gaps = 58/262 (22%)

Query: 234 LAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLN---------GLQDSAQLGNL 284
           L  L LE  SLS      LA+ L+   + +EL +++N +N         GL+DS      
Sbjct: 144 LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEA 203

Query: 285 LKF--------NC-----------SLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVL 325
           LK         NC           SL+ L L +N + D G+A +C GL      L TL +
Sbjct: 204 LKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWI 263

Query: 326 WNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVR--------------------- 364
           W   +T  G   L   L   +SL+ L+L  N +G+EG R                     
Sbjct: 264 WECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSC 323

Query: 365 --------HLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLR-LDLRENEIK 415
                   H  + L  NR +L L +++ +L   G   + + + +   +LR L L + ++ 
Sbjct: 324 SFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVS 383

Query: 416 TGGLMALSLALKVNHSLLRLDL 437
                +L+  L  NHSL  LDL
Sbjct: 384 DSSCSSLAATLLANHSLRELDL 405



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 42/148 (28%), Positives = 70/148 (47%), Gaps = 1/148 (0%)

Query: 281 LGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGM 340
           + + L+ N +L  L+LR+N + D G+  + +GL+     +  L L N  LT  G   L  
Sbjct: 48  ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107

Query: 341 TLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVL-RLGLASTKLTCEGAVAVAEFIA 399
           TL    +L+ L+L  N +G+ G++ L  GL+  +  L +L L    L+      +A  + 
Sbjct: 108 TLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLR 167

Query: 400 ESPRLLRLDLRENEIKTGGLMALSLALK 427
             P    L +  N+I   G+  L   LK
Sbjct: 168 AKPDFKELTVSNNDINEAGVRVLCQGLK 195



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 60/239 (25%), Positives = 92/239 (38%), Gaps = 29/239 (12%)

Query: 225 ARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNL 284
           A  L +     V+ L++  L+      +++AL++N  L EL L  N+L  +     L  L
Sbjct: 21  AELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGL 80

Query: 285 LKFNCSLQILDLRN----------------------------NHVLDSGLAYICEGLKEQ 316
              +C +Q L L+N                            N + D+GL  +CEGL + 
Sbjct: 81  QTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDP 140

Query: 317 RKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSV 376
           +  L  L L    L+      L   L      + L + +N I   GVR L  GL  +   
Sbjct: 141 QCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQ 200

Query: 377 LR-LGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLR 434
           L  L L S  +T +    +   +A    L  L L  N++   G+  L   L    S LR
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 66/278 (23%), Positives = 114/278 (41%), Gaps = 21/278 (7%)

Query: 108 RLDCLDLKGEKLDYKTCEALEEVFK-RLQFKVVDLEQTNLDE-----------DPRAEAE 155
           RL+ L L+   L   +CE L  V + +  FK + +   +++E           D   + E
Sbjct: 143 RLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLE 202

Query: 156 PPNLYAQGASA-----LFDMIEYYESATHLNISFNKHIGTRGW-QAAAHMMRKTSCLQYL 209
              L + G ++     L  ++    S   L +  NK +G  G  +    ++  +S L+ L
Sbjct: 203 ALKLESCGVTSDNCRDLCGIVASKASLRELALGSNK-LGDVGMAELCPGLLHPSSRLRTL 261

Query: 210 DARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLA-TALKMNMNLRELYLA 268
                 +       + R LR + SL  L L    L      LL  T L+    L  L++ 
Sbjct: 262 WIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVK 321

Query: 269 DNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNN 328
                    S    ++L  N  L  L + NN + D+G+  +C+GL +    L  L L + 
Sbjct: 322 SCSFTAACCS-HFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADC 380

Query: 329 QLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHL 366
            ++ +  + L  TL    SL  L+L +N +G+ G+  L
Sbjct: 381 DVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQL 418



 Score = 37.0 bits (84), Expect = 0.055
 Identities = 43/169 (25%), Positives = 75/169 (44%), Gaps = 4/169 (2%)

Query: 161 AQGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDH 219
           A+G   L  ++   ES   L+++ N+ +G  G +     + +  C L+ L  ++      
Sbjct: 270 AKGCGDLCRVLRAKESLKELSLAGNE-LGDEGARLLCETLLEPGCQLESLWVKSCSFTAA 328

Query: 220 SAPFVARALRIRSSLAVLHLENASLSGRPLMLLATAL-KMNMNLRELYLADNKLNGLQDS 278
                +  L     L  L + N  L    +  L   L +    LR L+LAD  ++    S
Sbjct: 329 CCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCS 388

Query: 279 AQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWN 327
           +    LL  N SL+ LDL NN + D+G+  + E +++    L  LVL++
Sbjct: 389 SLAATLLA-NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYD 436


>gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 71/262 (27%), Positives = 108/262 (41%), Gaps = 58/262 (22%)

Query: 234 LAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLN---------GLQDSAQLGNL 284
           L  L LE  SLS      LA+ L+   + +EL +++N +N         GL+DS      
Sbjct: 144 LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEA 203

Query: 285 LKF--------NC-----------SLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVL 325
           LK         NC           SL+ L L +N + D G+A +C GL      L TL +
Sbjct: 204 LKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWI 263

Query: 326 WNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVR--------------------- 364
           W   +T  G   L   L   +SL+ L+L  N +G+EG R                     
Sbjct: 264 WECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSC 323

Query: 365 --------HLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLR-LDLRENEIK 415
                   H  + L  NR +L L +++ +L   G   + + + +   +LR L L + ++ 
Sbjct: 324 SFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVS 383

Query: 416 TGGLMALSLALKVNHSLLRLDL 437
                +L+  L  NHSL  LDL
Sbjct: 384 DSSCSSLAATLLANHSLRELDL 405



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 42/148 (28%), Positives = 70/148 (47%), Gaps = 1/148 (0%)

Query: 281 LGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGM 340
           + + L+ N +L  L+LR+N + D G+  + +GL+     +  L L N  LT  G   L  
Sbjct: 48  ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107

Query: 341 TLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVL-RLGLASTKLTCEGAVAVAEFIA 399
           TL    +L+ L+L  N +G+ G++ L  GL+  +  L +L L    L+      +A  + 
Sbjct: 108 TLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLR 167

Query: 400 ESPRLLRLDLRENEIKTGGLMALSLALK 427
             P    L +  N+I   G+  L   LK
Sbjct: 168 AKPDFKELTVSNNDINEAGVRVLCQGLK 195



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 60/239 (25%), Positives = 92/239 (38%), Gaps = 29/239 (12%)

Query: 225 ARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNL 284
           A  L +     V+ L++  L+      +++AL++N  L EL L  N+L  +     L  L
Sbjct: 21  AELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGL 80

Query: 285 LKFNCSLQILDLRN----------------------------NHVLDSGLAYICEGLKEQ 316
              +C +Q L L+N                            N + D+GL  +CEGL + 
Sbjct: 81  QTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDP 140

Query: 317 RKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSV 376
           +  L  L L    L+      L   L      + L + +N I   GVR L  GL  +   
Sbjct: 141 QCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQ 200

Query: 377 LR-LGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLR 434
           L  L L S  +T +    +   +A    L  L L  N++   G+  L   L    S LR
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 66/278 (23%), Positives = 114/278 (41%), Gaps = 21/278 (7%)

Query: 108 RLDCLDLKGEKLDYKTCEALEEVFK-RLQFKVVDLEQTNLDE-----------DPRAEAE 155
           RL+ L L+   L   +CE L  V + +  FK + +   +++E           D   + E
Sbjct: 143 RLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLE 202

Query: 156 PPNLYAQGASA-----LFDMIEYYESATHLNISFNKHIGTRGW-QAAAHMMRKTSCLQYL 209
              L + G ++     L  ++    S   L +  NK +G  G  +    ++  +S L+ L
Sbjct: 203 ALKLESCGVTSDNCRDLCGIVASKASLRELALGSNK-LGDVGMAELCPGLLHPSSRLRTL 261

Query: 210 DARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLA-TALKMNMNLRELYLA 268
                 +       + R LR + SL  L L    L      LL  T L+    L  L++ 
Sbjct: 262 WIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVK 321

Query: 269 DNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNN 328
                    S    ++L  N  L  L + NN + D+G+  +C+GL +    L  L L + 
Sbjct: 322 SCSFTAACCS-HFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADC 380

Query: 329 QLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHL 366
            ++ +  + L  TL    SL  L+L +N +G+ G+  L
Sbjct: 381 DVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQL 418



 Score = 37.0 bits (84), Expect = 0.055
 Identities = 43/169 (25%), Positives = 75/169 (44%), Gaps = 4/169 (2%)

Query: 161 AQGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDH 219
           A+G   L  ++   ES   L+++ N+ +G  G +     + +  C L+ L  ++      
Sbjct: 270 AKGCGDLCRVLRAKESLKELSLAGNE-LGDEGARLLCETLLEPGCQLESLWVKSCSFTAA 328

Query: 220 SAPFVARALRIRSSLAVLHLENASLSGRPLMLLATAL-KMNMNLRELYLADNKLNGLQDS 278
                +  L     L  L + N  L    +  L   L +    LR L+LAD  ++    S
Sbjct: 329 CCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCS 388

Query: 279 AQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWN 327
           +    LL  N SL+ LDL NN + D+G+  + E +++    L  LVL++
Sbjct: 389 SLAATLLA-NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYD 436


>gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 71/262 (27%), Positives = 108/262 (41%), Gaps = 58/262 (22%)

Query: 234 LAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLN---------GLQDSAQLGNL 284
           L  L LE  SLS      LA+ L+   + +EL +++N +N         GL+DS      
Sbjct: 144 LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEA 203

Query: 285 LKF--------NC-----------SLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVL 325
           LK         NC           SL+ L L +N + D G+A +C GL      L TL +
Sbjct: 204 LKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWI 263

Query: 326 WNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVR--------------------- 364
           W   +T  G   L   L   +SL+ L+L  N +G+EG R                     
Sbjct: 264 WECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSC 323

Query: 365 --------HLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLR-LDLRENEIK 415
                   H  + L  NR +L L +++ +L   G   + + + +   +LR L L + ++ 
Sbjct: 324 SFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVS 383

Query: 416 TGGLMALSLALKVNHSLLRLDL 437
                +L+  L  NHSL  LDL
Sbjct: 384 DSSCSSLAATLLANHSLRELDL 405



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 42/148 (28%), Positives = 70/148 (47%), Gaps = 1/148 (0%)

Query: 281 LGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGM 340
           + + L+ N +L  L+LR+N + D G+  + +GL+     +  L L N  LT  G   L  
Sbjct: 48  ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107

Query: 341 TLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVL-RLGLASTKLTCEGAVAVAEFIA 399
           TL    +L+ L+L  N +G+ G++ L  GL+  +  L +L L    L+      +A  + 
Sbjct: 108 TLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLR 167

Query: 400 ESPRLLRLDLRENEIKTGGLMALSLALK 427
             P    L +  N+I   G+  L   LK
Sbjct: 168 AKPDFKELTVSNNDINEAGVRVLCQGLK 195



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 60/239 (25%), Positives = 92/239 (38%), Gaps = 29/239 (12%)

Query: 225 ARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNL 284
           A  L +     V+ L++  L+      +++AL++N  L EL L  N+L  +     L  L
Sbjct: 21  AELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGL 80

Query: 285 LKFNCSLQILDLRN----------------------------NHVLDSGLAYICEGLKEQ 316
              +C +Q L L+N                            N + D+GL  +CEGL + 
Sbjct: 81  QTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDP 140

Query: 317 RKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSV 376
           +  L  L L    L+      L   L      + L + +N I   GVR L  GL  +   
Sbjct: 141 QCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQ 200

Query: 377 LR-LGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLR 434
           L  L L S  +T +    +   +A    L  L L  N++   G+  L   L    S LR
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 66/278 (23%), Positives = 114/278 (41%), Gaps = 21/278 (7%)

Query: 108 RLDCLDLKGEKLDYKTCEALEEVFK-RLQFKVVDLEQTNLDE-----------DPRAEAE 155
           RL+ L L+   L   +CE L  V + +  FK + +   +++E           D   + E
Sbjct: 143 RLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLE 202

Query: 156 PPNLYAQGASA-----LFDMIEYYESATHLNISFNKHIGTRGW-QAAAHMMRKTSCLQYL 209
              L + G ++     L  ++    S   L +  NK +G  G  +    ++  +S L+ L
Sbjct: 203 ALKLESCGVTSDNCRDLCGIVASKASLRELALGSNK-LGDVGMAELCPGLLHPSSRLRTL 261

Query: 210 DARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLA-TALKMNMNLRELYLA 268
                 +       + R LR + SL  L L    L      LL  T L+    L  L++ 
Sbjct: 262 WIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVK 321

Query: 269 DNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNN 328
                    S    ++L  N  L  L + NN + D+G+  +C+GL +    L  L L + 
Sbjct: 322 SCSFTAACCS-HFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADC 380

Query: 329 QLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHL 366
            ++ +  + L  TL    SL  L+L +N +G+ G+  L
Sbjct: 381 DVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQL 418



 Score = 37.0 bits (84), Expect = 0.055
 Identities = 43/169 (25%), Positives = 75/169 (44%), Gaps = 4/169 (2%)

Query: 161 AQGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDH 219
           A+G   L  ++   ES   L+++ N+ +G  G +     + +  C L+ L  ++      
Sbjct: 270 AKGCGDLCRVLRAKESLKELSLAGNE-LGDEGARLLCETLLEPGCQLESLWVKSCSFTAA 328

Query: 220 SAPFVARALRIRSSLAVLHLENASLSGRPLMLLATAL-KMNMNLRELYLADNKLNGLQDS 278
                +  L     L  L + N  L    +  L   L +    LR L+LAD  ++    S
Sbjct: 329 CCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCS 388

Query: 279 AQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWN 327
           +    LL  N SL+ LDL NN + D+G+  + E +++    L  LVL++
Sbjct: 389 SLAATLLA-NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYD 436


>gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 70.1 bits (170), Expect = 6e-12
 Identities = 71/262 (27%), Positives = 108/262 (41%), Gaps = 58/262 (22%)

Query: 234 LAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLN---------GLQDSAQLGNL 284
           L  L LE  SLS      LA+ L+   + +EL +++N +N         GL+DS      
Sbjct: 144 LEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEA 203

Query: 285 LKF--------NC-----------SLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVL 325
           LK         NC           SL+ L L +N + D G+A +C GL      L TL +
Sbjct: 204 LKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWI 263

Query: 326 WNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVR--------------------- 364
           W   +T  G   L   L   +SL+ L+L  N +G+EG R                     
Sbjct: 264 WECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVKSC 323

Query: 365 --------HLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLR-LDLRENEIK 415
                   H  + L  NR +L L +++ +L   G   + + + +   +LR L L + ++ 
Sbjct: 324 SFTAACCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVS 383

Query: 416 TGGLMALSLALKVNHSLLRLDL 437
                +L+  L  NHSL  LDL
Sbjct: 384 DSSCSSLAATLLANHSLRELDL 405



 Score = 56.6 bits (135), Expect = 7e-08
 Identities = 42/148 (28%), Positives = 70/148 (47%), Gaps = 1/148 (0%)

Query: 281 LGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGM 340
           + + L+ N +L  L+LR+N + D G+  + +GL+     +  L L N  LT  G   L  
Sbjct: 48  ISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSS 107

Query: 341 TLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVL-RLGLASTKLTCEGAVAVAEFIA 399
           TL    +L+ L+L  N +G+ G++ L  GL+  +  L +L L    L+      +A  + 
Sbjct: 108 TLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLR 167

Query: 400 ESPRLLRLDLRENEIKTGGLMALSLALK 427
             P    L +  N+I   G+  L   LK
Sbjct: 168 AKPDFKELTVSNNDINEAGVRVLCQGLK 195



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 60/239 (25%), Positives = 92/239 (38%), Gaps = 29/239 (12%)

Query: 225 ARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNL 284
           A  L +     V+ L++  L+      +++AL++N  L EL L  N+L  +     L  L
Sbjct: 21  AELLPLLQQCQVVRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGL 80

Query: 285 LKFNCSLQILDLRN----------------------------NHVLDSGLAYICEGLKEQ 316
              +C +Q L L+N                            N + D+GL  +CEGL + 
Sbjct: 81  QTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDP 140

Query: 317 RKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSV 376
           +  L  L L    L+      L   L      + L + +N I   GVR L  GL  +   
Sbjct: 141 QCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQ 200

Query: 377 LR-LGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLR 434
           L  L L S  +T +    +   +A    L  L L  N++   G+  L   L    S LR
Sbjct: 201 LEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLR 259



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 66/278 (23%), Positives = 114/278 (41%), Gaps = 21/278 (7%)

Query: 108 RLDCLDLKGEKLDYKTCEALEEVFK-RLQFKVVDLEQTNLDE-----------DPRAEAE 155
           RL+ L L+   L   +CE L  V + +  FK + +   +++E           D   + E
Sbjct: 143 RLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLE 202

Query: 156 PPNLYAQGASA-----LFDMIEYYESATHLNISFNKHIGTRGW-QAAAHMMRKTSCLQYL 209
              L + G ++     L  ++    S   L +  NK +G  G  +    ++  +S L+ L
Sbjct: 203 ALKLESCGVTSDNCRDLCGIVASKASLRELALGSNK-LGDVGMAELCPGLLHPSSRLRTL 261

Query: 210 DARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLA-TALKMNMNLRELYLA 268
                 +       + R LR + SL  L L    L      LL  T L+    L  L++ 
Sbjct: 262 WIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEGARLLCETLLEPGCQLESLWVK 321

Query: 269 DNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNN 328
                    S    ++L  N  L  L + NN + D+G+  +C+GL +    L  L L + 
Sbjct: 322 SCSFTAACCS-HFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADC 380

Query: 329 QLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHL 366
            ++ +  + L  TL    SL  L+L +N +G+ G+  L
Sbjct: 381 DVSDSSCSSLAATLLANHSLRELDLSNNCLGDAGILQL 418



 Score = 37.0 bits (84), Expect = 0.055
 Identities = 43/169 (25%), Positives = 75/169 (44%), Gaps = 4/169 (2%)

Query: 161 AQGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDH 219
           A+G   L  ++   ES   L+++ N+ +G  G +     + +  C L+ L  ++      
Sbjct: 270 AKGCGDLCRVLRAKESLKELSLAGNE-LGDEGARLLCETLLEPGCQLESLWVKSCSFTAA 328

Query: 220 SAPFVARALRIRSSLAVLHLENASLSGRPLMLLATAL-KMNMNLRELYLADNKLNGLQDS 278
                +  L     L  L + N  L    +  L   L +    LR L+LAD  ++    S
Sbjct: 329 CCSHFSSVLAQNRFLLELQISNNRLEDAGVRELCQGLGQPGSVLRVLWLADCDVSDSSCS 388

Query: 279 AQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWN 327
           +    LL  N SL+ LDL NN + D+G+  + E +++    L  LVL++
Sbjct: 389 SLAATLLA-NHSLRELDLSNNCLGDAGILQLVESVRQPGCLLEQLVLYD 436


>gi|168986655 hypothetical protein LOC145497 [Homo sapiens]
          Length = 488

 Score = 69.7 bits (169), Expect = 8e-12
 Identities = 63/220 (28%), Positives = 106/220 (48%), Gaps = 5/220 (2%)

Query: 225 ARALRIRSSLAV--LHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLG 282
           A A+ + S++AV  L LE+  +    ++ L   L+ N  L+E+ +++N L GL+ +  + 
Sbjct: 124 AIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHL-GLEGARIIS 182

Query: 283 NLLKFNCS-LQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMT 341
           +  + N S +  L+L  N   +   A +C+ L    + +  L L +NQ +  G   LG  
Sbjct: 183 DFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQ-IKKLDLSHNQFSDVGGEHLGQM 241

Query: 342 LPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAES 401
           L     L +L+L  N     G   L NGL  N ++ +L L+      E A+A+ E +  +
Sbjct: 242 LAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLN 301

Query: 402 PRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREP 441
             L+ LD+  N+I   G   +S  L+ N SL  L L   P
Sbjct: 302 RCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNP 341



 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 55/201 (27%), Positives = 88/201 (43%), Gaps = 1/201 (0%)

Query: 237 LHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDL 296
           ++L +  L  R    +A AL  NM + +L L DN +   +    L  +L+ N  LQ +++
Sbjct: 110 VNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIME-EGVLSLVEMLQENYYLQEMNI 168

Query: 297 RNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHN 356
            NNH+   G   I +  +     + +L L  N       A L   L     ++ L+L HN
Sbjct: 169 SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228

Query: 357 PIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKT 416
              + G  HL   L  N  +  L L+       GAVA+   +  +  L +LDL  N    
Sbjct: 229 QFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGN 288

Query: 417 GGLMALSLALKVNHSLLRLDL 437
              +AL   L++N  L+ LD+
Sbjct: 289 EVALALGEVLRLNRCLVYLDI 309



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 69/264 (26%), Positives = 107/264 (40%), Gaps = 38/264 (14%)

Query: 151 RAEAEPPNLYAQGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLD 210
           + E E   +  +G  +L +M++       +NIS N H+G  G +  +    + S      
Sbjct: 137 KLELEDNCIMEEGVLSLVEMLQENYYLQEMNIS-NNHLGLEGARIISDFFERNS------ 189

Query: 211 ARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADN 270
                                SS+  L L           LL  AL  N  +++L L+ N
Sbjct: 190 ---------------------SSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228

Query: 271 KLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQL 330
           + + +     LG +L  N  L  LDL  N+    G   +C GL+    G VTL   +  +
Sbjct: 229 QFSDV-GGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLR----GNVTLTKLDLSM 283

Query: 331 THTGMAF---LGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLT 387
              G      LG  L   + L  L++G N IGNEG   +  GL SN S+  L L    + 
Sbjct: 284 NGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPIN 343

Query: 388 CEGAVAVAEFIAESP--RLLRLDL 409
            +GA+ +   I  +P  R+  LD+
Sbjct: 344 MDGAILLILAIKRNPKSRMEELDI 367


>gi|21450705 leucine rich repeat containing 45 [Homo sapiens]
          Length = 670

 Score = 69.7 bits (169), Expect = 8e-12
 Identities = 77/262 (29%), Positives = 112/262 (42%), Gaps = 7/262 (2%)

Query: 237 LHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDL 296
           L L +  LS     LL   L  N  LR L L  N L      A LG LL+ N S+Q L L
Sbjct: 63  LVLSDCMLSEEGATLLLRGLCANTVLRFLDLKGNNLRAAGAEA-LGKLLQQNKSIQSLTL 121

Query: 297 RNNHV--LDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLG 354
             N +   D   A  C GL      L  L L NNQ++H G   L + L    +L+ L+L 
Sbjct: 122 EWNSLGTWDDAFATFCGGLAANG-ALQRLDLRNNQISHKGAEELALALKGNTTLQQLDLR 180

Query: 355 HNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEI 414
            N +G  G R L N L SNR++ RL LA   +  +   AV + +  S   L    +EN+ 
Sbjct: 181 WNNVGLLGGRALMNCLPSNRTLWRLDLAGNNIPGDVLRAVEQAMGHSQDRL-TTFQENQA 239

Query: 415 KTGGLMALSLALKVNHSLLRLDLDR--EPKKEAVKSFIETQKALLAEIQNGCKRNLVLAR 472
           +T  L      L+   S   LDL    + ++E +        A + ++Q        +  
Sbjct: 240 RTHVLSKEVQHLREEKSKQFLDLMETIDKQREEMAKSSRASAARVGQLQEALNERHSIIN 299

Query: 473 EREEKEQPPQLSASMPETTATE 494
             + K Q  + + ++ E  A +
Sbjct: 300 ALKAKLQMTEAALALSEQKAQD 321



 Score = 43.9 bits (102), Expect = 4e-04
 Identities = 103/457 (22%), Positives = 172/457 (37%), Gaps = 95/457 (20%)

Query: 73  VDEVIGAYKQACQKLNCRQIPKLLRQLQEFTDLGHRLDCLDLKGEKLDYKTCEALEEVFK 132
           ++E   +Y + C++        +L+QL +          LDL  + L  +TC AL ++  
Sbjct: 1   MEEFRRSYSRLCRESGAEPQEAVLQQLHQLPR-----GRLDLATQSLTVETCRALGKLLP 55

Query: 133 R--LQFKVVDLEQTNLDEDPRA---------------EAEPPNLYAQGASALFDMIEYYE 175
           R  L  ++V L    L E+                  + +  NL A GA AL  +++  +
Sbjct: 56  RETLCTELV-LSDCMLSEEGATLLLRGLCANTVLRFLDLKGNNLRAAGAEALGKLLQQNK 114

Query: 176 SATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLA 235
           S   L + +N  +GT  W                        D  A F    L    +L 
Sbjct: 115 SIQSLTLEWNS-LGT--WD-----------------------DAFATFCG-GLAANGALQ 147

Query: 236 VLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILD 295
            L L N  +S +    LA ALK N  L++L L  N + GL     L N L  N +L  LD
Sbjct: 148 RLDLRNNQISHKGAEELALALKGNTTLQQLDLRWNNV-GLLGGRALMNCLPSNRTLWRLD 206

Query: 296 LRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQS-------- 347
           L  N++    L  + + +   +  L T    N   TH     L   + H +         
Sbjct: 207 LAGNNIPGDVLRAVEQAMGHSQDRLTTF-QENQARTHV----LSKEVQHLREEKSKQFLD 261

Query: 348 -LETLNLGHNPIGNEG------VRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAE 400
            +ET++     +          V  L+  L    S++    A  ++T E A+A++E  A+
Sbjct: 262 LMETIDKQREEMAKSSRASAARVGQLQEALNERHSIINALKAKLQMT-EAALALSEQKAQ 320

Query: 401 SPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEI 460
               L     + ++      A  L L+              ++EA     E +  LL ++
Sbjct: 321 DLGELLATAEQEQLSLSQRQAKELKLE--------------QQEAA----ERESKLLRDL 362

Query: 461 QNGCKRNLVLAREREEKE-----QPPQLSASMPETTA 492
               ++NL+L  + +E E     Q  QL  +  E T+
Sbjct: 363 SAANEKNLLLQNQVDELERKFRCQQEQLFQTRQEMTS 399


>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
          Length = 1200

 Score = 69.3 bits (168), Expect = 1e-11
 Identities = 78/266 (29%), Positives = 123/266 (46%), Gaps = 11/266 (4%)

Query: 176  SATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDHSAPFVARALRIRSSL 234
            S   L+++ NK +  +G    +  +R + C LQ L   +  +       +A AL    SL
Sbjct: 895  SLKSLSLAGNK-VTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSL 953

Query: 235  AVLHLENASLSGRPLMLLATALKM-NMNLRELYLADNKLNGLQDSAQLGNL---LKFNCS 290
              L L N SL    + LL  ++++ + +L+ L L    L    D+A  G L   L  N  
Sbjct: 954  THLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHL----DTAGCGFLALALMGNSW 1009

Query: 291  LQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLET 350
            L  L L  N V D+G+  +CE ++E    L  L L    LT      L   +  ++ L++
Sbjct: 1010 LTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKS 1069

Query: 351  LNLGHNPIGNEGVRHLKNGLISNRSVL-RLGLASTKLTCEGAVAVAEFIAESPRLLRLDL 409
            L+L  N +G+ GV  L  GL    SVL RLGL +  LT +   A++  ++ +  L  L+L
Sbjct: 1070 LDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNL 1129

Query: 410  RENEIKTGGLMALSLALKVNHSLLRL 435
             +N     G+M L  A     S L++
Sbjct: 1130 VQNNFSPKGMMKLCSAFACPTSNLQI 1155



 Score = 58.9 bits (141), Expect = 1e-08
 Identities = 64/228 (28%), Positives = 97/228 (42%), Gaps = 9/228 (3%)

Query: 198  HMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALK 257
            H   K   L + +A+ TP + H    V     +RS    L+L    L    + +   ALK
Sbjct: 807  HPTCKIQTLMFRNAQITPGVQHLWRIVMANRNLRS----LNLGGTHLKEEDVRMACEALK 862

Query: 258  MNMNLRELYLADNKLNGLQDSAQL--GNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKE 315
                L E    D    GL  +  L    +L  + SL+ L L  N V D G+  + + L+ 
Sbjct: 863  HPKCLLESLRLD--CCGLTHACYLKISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRV 920

Query: 316  QRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGL-ISNR 374
             +  L  L+L +  +T TG   L   L   +SL  L L +N +GNEGV  L   + + + 
Sbjct: 921  SQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVNLLCRSMRLPHC 980

Query: 375  SVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMAL 422
            S+ RL L    L   G   +A  +  +  L  L L  N ++  G+  L
Sbjct: 981  SLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLL 1028



 Score = 50.8 bits (120), Expect = 4e-06
 Identities = 56/217 (25%), Positives = 89/217 (41%), Gaps = 39/217 (17%)

Query: 281  LGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGM 340
            L  ++  N +L+ L+L   H+ +  +   CE LK  +  L +L L    LTH     +  
Sbjct: 829  LWRIVMANRNLRSLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQ 888

Query: 341  TLPHTQSLETLNLGHNPIGNEGV-----------------------------RHLKNGLI 371
             L  + SL++L+L  N + ++GV                             + L + L+
Sbjct: 889  ILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALV 948

Query: 372  SNRSVLRLGLASTKLTCEGAVAVAEFIAESPRL-----LRLDLRENEIKTGGLMALSLAL 426
            SNRS+  L L++  L  EG       +  S RL      RL L +  + T G   L+LAL
Sbjct: 949  SNRSLTHLCLSNNSLGNEGV----NLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALAL 1004

Query: 427  KVNHSLLRLDLDREPKKE-AVKSFIETQKALLAEIQN 462
              N  L  L L   P ++  VK   E  +     +Q+
Sbjct: 1005 MGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQD 1041


>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
           sapiens]
          Length = 979

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 73/245 (29%), Positives = 110/245 (44%), Gaps = 13/245 (5%)

Query: 167 LFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPL----LDHSAP 222
           LF ++   +S T L++S N  +G  G +     ++   C    + R   L    L H   
Sbjct: 733 LFSVLSTSQSLTELDLSDNS-LGDPGMRVLCETLQHPGC----NIRRLWLGRCGLSHECC 787

Query: 223 F-VARALRIRSSLAVLHLENASLSGRPLMLLATALK-MNMNLRELYLADNKLNGLQDSAQ 280
           F ++  L     L  L L + +L    + LL   LK +  NL++L+L ++ L  +  SA 
Sbjct: 788 FDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSA- 846

Query: 281 LGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGM 340
           L ++L  N +L  L LR N + D G+  +CEGL      L  L L N  LT      L  
Sbjct: 847 LSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLST 906

Query: 341 TLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLR-LGLASTKLTCEGAVAVAEFIA 399
            L  +QSL  L+LG+N +G+ GV      L     +L+ LGL+      E   A+     
Sbjct: 907 LLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQE 966

Query: 400 ESPRL 404
           E P L
Sbjct: 967 EKPEL 971



 Score = 39.7 bits (91), Expect = 0.008
 Identities = 31/104 (29%), Positives = 52/104 (50%), Gaps = 1/104 (0%)

Query: 325 LWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGL-ISNRSVLRLGLAS 383
           L N+ LT +    L   L  +QSL  L+L  N +G+ G+R L   L     ++ RL L  
Sbjct: 720 LVNSHLTSSFCRGLFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGR 779

Query: 384 TKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALK 427
             L+ E    ++  ++ + +L+ LDL +N +   G+  L + LK
Sbjct: 780 CGLSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLK 823


>gi|116268109 nucleotide-binding oligomerization domains 27 [Homo
            sapiens]
          Length = 1866

 Score = 68.6 bits (166), Expect = 2e-11
 Identities = 77/266 (28%), Positives = 112/266 (42%), Gaps = 11/266 (4%)

Query: 188  IGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGR 247
            + T G    A  +     L+ LD  N    +     + RAL  +  L  L L +  L+  
Sbjct: 1506 VSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSS 1565

Query: 248  PLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSG-- 305
             L LL   L     L+ L L  N + G      L   L+   SL+ LDL +N + D+G  
Sbjct: 1566 TLALLTHRLSQMTCLQSLRLNRNSI-GDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQ 1624

Query: 306  -LAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVR 364
             LA I  GL E RK    + L  N ++  G   L  +L   + LE L LG N +G+    
Sbjct: 1625 HLATILPGLPELRK----IDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTAL 1680

Query: 365  HLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGL-MALS 423
             L   L  +  VL L    + L   GA+++A+ +  SP L  + L EN +  G L   + 
Sbjct: 1681 GLAQELPQHLRVLHLPF--SHLGPGGALSLAQALDGSPHLEEISLAENNLAGGVLRFCME 1738

Query: 424  LALKVNHSLLRLDLDREPKKEAVKSF 449
            L L     L+   +D +  K    SF
Sbjct: 1739 LPLLRQIDLVSCKIDNQTAKLLTSSF 1764



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 66/220 (30%), Positives = 100/220 (45%), Gaps = 4/220 (1%)

Query: 218  DHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQD 277
            D S+  +   L   S L    L ++ +S   L  LA+ L    +L EL L++N+ +  + 
Sbjct: 1480 DASSLLLQSLLLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDE-EG 1538

Query: 278  SAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAF 337
            +  L   L+    L+ LDL +  +  S LA +   L  Q   L +L L  N +   G   
Sbjct: 1539 TKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLS-QMTCLQSLRLNRNSIGDVGCCH 1597

Query: 338  LGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEF 397
            L   L    SLE L+L HN IG+ GV+HL   L     + ++ L+   ++  G V +AE 
Sbjct: 1598 LSEALRAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAES 1657

Query: 398  IAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDL 437
            +    RL  L L  N +  G   AL LA ++   L  L L
Sbjct: 1658 LVLCRRLEELMLGCNAL--GDPTALGLAQELPQHLRVLHL 1695



 Score = 50.4 bits (119), Expect = 5e-06
 Identities = 50/190 (26%), Positives = 77/190 (40%), Gaps = 2/190 (1%)

Query: 274  GLQDSAQLGNLLKFNCSLQILDLRNNHVL--DSGLAYICEGLKEQRKGLVTLVLWNNQLT 331
            G   S  +G L++    LQ L L   ++   D   + + + L      L T  L ++ ++
Sbjct: 1448 GAHHSLLVGQLMETCARLQQLSLSQVNLCEDDDASSLLLQSLLLSLSELKTFRLTSSCVS 1507

Query: 332  HTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGA 391
              G+A L   L H   LE L+L +N    EG + L   L     + RL L+   L     
Sbjct: 1508 TEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTL 1567

Query: 392  VAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEAVKSFIE 451
              +   +++   L  L L  N I   G   LS AL+   SL  LDL      +A    + 
Sbjct: 1568 ALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLA 1627

Query: 452  TQKALLAEIQ 461
            T    L E++
Sbjct: 1628 TILPGLPELR 1637



 Score = 49.3 bits (116), Expect = 1e-05
 Identities = 64/269 (23%), Positives = 107/269 (39%), Gaps = 30/269 (11%)

Query: 198  HMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALK 257
            H + + +CLQ L      + D     ++ ALR  +SL  L L +  +    +  LAT L 
Sbjct: 1572 HRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEELDLSHNQIGDAGVQHLATILP 1631

Query: 258  MNMNLRELYLADNKL-------------------------NGLQDSAQLGNLLKFNCSLQ 292
                LR++ L+ N +                         N L D   LG   +    L+
Sbjct: 1632 GLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQELPQHLR 1691

Query: 293  ILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLN 352
            +L L  +H+   G   + + L +    L  + L  N L    + F  M LP    L  ++
Sbjct: 1692 VLHLPFSHLGPGGALSLAQAL-DGSPHLEEISLAENNLAGGVLRFC-MELP---LLRQID 1746

Query: 353  LGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLREN 412
            L    I N+  + L +   S  ++  + L+   L  E A  +A+ + +  RL R+DL +N
Sbjct: 1747 LVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKN 1806

Query: 413  EIKTGGLMALSLALKVNHSLLRLDLDREP 441
            +I   G   L+  L    S+  + L   P
Sbjct: 1807 QITALGAWLLAEGLAQGSSIQVIRLWNNP 1835



 Score = 45.1 bits (105), Expect = 2e-04
 Identities = 67/274 (24%), Positives = 113/274 (41%), Gaps = 20/274 (7%)

Query: 218 DHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQD 277
           D  A  ++R+L     L +L L  + ++ R +  L  AL +   L+E+   DN+L+  Q 
Sbjct: 700 DAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKEVSFRDNQLSD-QV 758

Query: 278 SAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAF 337
              +  +L     L+ LDL +N +  S L  +       R  +    +   Q     + F
Sbjct: 759 VLNIVEVLPHLPRLRKLDLSSNSICVSTLLCLA------RVAVTCPTVRMLQAREADLIF 812

Query: 338 LGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEF 397
           L    P T++   L    +   ++G R    G  S    LRL     +L    A A+   
Sbjct: 813 L--LSPPTETTAELQRAPDLQESDGQR---KGAQSRSLTLRL--QKCQLQVHDAEALIAL 865

Query: 398 IAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDL-DREPKKEAVKSFIETQKA- 455
           + E P L  +DL  N+++  G   ++ A    H   +LDL D       V   +    A 
Sbjct: 866 LQEGPHLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSDNGLSVAGVHCVLRAVSAC 925

Query: 456 -LLAEIQNGCKRNLVL---AREREEKEQPPQLSA 485
             LAE+    +   V+   A+E EE++ P + +A
Sbjct: 926 WTLAELHISLQHKTVIFMFAQEPEEQKGPQERAA 959



 Score = 38.9 bits (89), Expect = 0.014
 Identities = 43/165 (26%), Positives = 72/165 (43%), Gaps = 24/165 (14%)

Query: 227  ALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNG--LQDSAQLGNL 284
            A  +   L VLHL  + L     + LA AL  + +L E+ LA+N L G  L+   +L  L
Sbjct: 1683 AQELPQHLRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAENNLAGGVLRFCMELPLL 1742

Query: 285  LKFNC---------------------SLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTL 323
             + +                      +L+++ L  N + D   A + + L +  + L  +
Sbjct: 1743 RQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDEAAAELAQVLPQMGR-LKRV 1801

Query: 324  VLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKN 368
             L  NQ+T  G   L   L    S++ + L +NPI  +  +HLK+
Sbjct: 1802 DLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPIPCDMAQHLKS 1846



 Score = 33.1 bits (74), Expect = 0.79
 Identities = 38/166 (22%), Positives = 65/166 (39%), Gaps = 13/166 (7%)

Query: 348 LETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRL 407
           +E L+      G+     L   L +   +  LGLA +K+T  G   + + +   P+L  +
Sbjct: 688 IENLSFKSRKCGDAFAEALSRSLPTMGRLQMLGLAGSKITARGISHLVKALPLCPQLKEV 747

Query: 408 DLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEAVKSFIETQKALLAEIQNGCKRN 467
             R+N++    ++ +   L     L +LDL       +  S   +    LA +   C   
Sbjct: 748 SFRDNQLSDQVVLNIVEVLPHLPRLRKLDL-------SSNSICVSTLLCLARVAVTCP-- 798

Query: 468 LVLAREREEKEQPPQLSASMPETTATEPQ--PDDEPAAGVQNGAPS 511
               R  + +E       S P  T  E Q  PD + + G + GA S
Sbjct: 799 --TVRMLQAREADLIFLLSPPTETTAELQRAPDLQESDGQRKGAQS 842


>gi|61175232 hypothetical protein LOC221424 [Homo sapiens]
          Length = 316

 Score = 66.6 bits (161), Expect = 6e-11
 Identities = 64/218 (29%), Positives = 102/218 (46%), Gaps = 6/218 (2%)

Query: 202 KTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRP-LMLLATALKMNM 260
           + + ++ L  R   L D     + RAL   +SLA L+L    +S    +  LA AL+ N 
Sbjct: 26  RDNAVRLLSLRGCRLCDRDFGRICRALAGATSLAQLNLNLGVVSSPSRIKQLAEALRTNR 85

Query: 261 NLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQ--RK 318
           +++ L+L  + L      A L   L  + +L  LDL +  + D  +  IC  L     + 
Sbjct: 86  SIQSLFLHGSPLTDA-GLALLNPALALHPALVALDLGDCMLGDEAINLICGLLPPDGAKS 144

Query: 319 GLVTLVLWNNQ-LTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVL 377
           GL  L L  N  +T  G + L + + H+  +  LNL +NP+G+     L   + S+R++ 
Sbjct: 145 GLKELTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLE 204

Query: 378 RLGLASTKLTCEGAVAVAEFIAESPRLLR-LDLRENEI 414
            L L  T LT + A  + + +   P  LR L L EN I
Sbjct: 205 VLDLEGTGLTNQSAQTLLDMVENYPTALRSLVLAENSI 242



 Score = 40.4 bits (93), Expect = 0.005
 Identities = 30/95 (31%), Positives = 45/95 (47%), Gaps = 1/95 (1%)

Query: 180 LNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHL 239
           L +S N  I  +GW   A  +  +S ++ L+    PL DH A  +A A+    +L VL L
Sbjct: 149 LTLSANPGITPKGWSRLAIAVAHSSQVRVLNLDYNPLGDHVAGMLAVAVASSRTLEVLDL 208

Query: 240 ENASLSGRPLM-LLATALKMNMNLRELYLADNKLN 273
           E   L+ +    LL         LR L LA+N ++
Sbjct: 209 EGTGLTNQSAQTLLDMVENYPTALRSLVLAENSIS 243



 Score = 31.6 bits (70), Expect = 2.3
 Identities = 42/190 (22%), Positives = 73/190 (38%), Gaps = 5/190 (2%)

Query: 176 SATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIRSSLA 235
           S   LN++          +  A  +R    +Q L    +PL D     +  AL +  +L 
Sbjct: 57  SLAQLNLNLGVVSSPSRIKQLAEALRTNRSIQSLFLHGSPLTDAGLALLNPALALHPALV 116

Query: 236 VLHLENASLSGRPLMLLATALK---MNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQ 292
            L L +  L    + L+   L        L+EL L+ N     +  ++L   +  +  ++
Sbjct: 117 ALDLGDCMLGDEAINLICGLLPPDGAKSGLKELTLSANPGITPKGWSRLAIAVAHSSQVR 176

Query: 293 ILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTH-TGMAFLGMTLPHTQSLETL 351
           +L+L  N + D     +   +   R  L  L L    LT+ +    L M   +  +L +L
Sbjct: 177 VLNLDYNPLGDHVAGMLAVAVASSRT-LEVLDLEGTGLTNQSAQTLLDMVENYPTALRSL 235

Query: 352 NLGHNPIGNE 361
            L  N I  E
Sbjct: 236 VLAENSISPE 245


>gi|11545912 nucleotide-binding oligomerization domain containing 2
           [Homo sapiens]
          Length = 1040

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 56/175 (32%), Positives = 83/175 (47%), Gaps = 2/175 (1%)

Query: 263 RELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVT 322
           + LYL DN ++  +   +L         LQ L L NN + D G A+    L   R+  + 
Sbjct: 818 KALYLRDNNISD-RGICKLIECALHCEQLQKLALFNNKLTD-GCAHSMAKLLACRQNFLA 875

Query: 323 LVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLA 382
           L L NN +T  G   L   L    SL+ L    N +G+EG + L   L  ++S+  L L 
Sbjct: 876 LRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLV 935

Query: 383 STKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDL 437
              +   GA A+A  +A++  L  L L EN ++  G+ +L+  LK N SL  L L
Sbjct: 936 GNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKL 990



 Score = 62.4 bits (150), Expect = 1e-09
 Identities = 61/200 (30%), Positives = 92/200 (46%), Gaps = 4/200 (2%)

Query: 237  LHLENASLSGRPLMLLATALKMNMNLRELYLADNKL-NGLQDSAQLGNLLKFNCSLQILD 295
            L+L + ++S R +  L         L++L L +NKL +G   S  +  LL    +   L 
Sbjct: 820  LYLRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHS--MAKLLACRQNFLALR 877

Query: 296  LRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGH 355
            L NN++  +G   + EGL+     L  L  W N++   G   L   L   QSL  L+L  
Sbjct: 878  LGNNYITAAGAQVLAEGLRGNTS-LQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVG 936

Query: 356  NPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIK 415
            N IG+ G + L   L  N  +  L L    L  EG  ++AE + ++  L  L L  N I 
Sbjct: 937  NNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCIT 996

Query: 416  TGGLMALSLALKVNHSLLRL 435
              G  AL  AL+ N ++L +
Sbjct: 997  YLGAEALLQALERNDTILEV 1016



 Score = 60.1 bits (144), Expect = 6e-09
 Identities = 56/176 (31%), Positives = 81/176 (46%), Gaps = 6/176 (3%)

Query: 294 LDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNL 353
           L LR+N++ D G+  + E      + L  L L+NN+LT      +   L   Q+   L L
Sbjct: 820 LYLRDNNISDRGICKLIECALHCEQ-LQKLALFNNKLTDGCAHSMAKLLACRQNFLALRL 878

Query: 354 GHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENE 413
           G+N I   G + L  GL  N S+  LG    ++  EGA A+AE + +   L  L L  N 
Sbjct: 879 GNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNN 938

Query: 414 IKTGGLMALSLALKVNHSLLRLDLDREP-KKEAVKSFIETQK----ALLAEIQNGC 464
           I + G  AL+L L  N  L  L L+    + E V S  E  K      + ++ N C
Sbjct: 939 IGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNC 994


>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
          Length = 1062

 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 69/252 (27%), Positives = 110/252 (43%), Gaps = 40/252 (15%)

Query: 218  DHSAPFVARALRI-RSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQ 276
            D   P +   LR    +L  L L + S + +    L+ AL++N +L  + L+DN+L  L 
Sbjct: 768  DDMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSLALEVNQSLTCVNLSDNEL--LD 825

Query: 277  DSAQL--GNLLKFNCSLQILDLRNNHVLD----------------------------SGL 306
            + A+L    L    C LQ L L N H+ +                            +G+
Sbjct: 826  EGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVVSRELTHLCLAKNPIGNTGV 885

Query: 307  AYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRH- 365
             ++CEGL+     L TLVLWN  +T  G   L   L    SL  L+LG N IG +G++  
Sbjct: 886  KFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSSLLCLDLGLNHIGVKGMKFL 945

Query: 366  ---LKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMAL 422
               L+  L + R +   G +    +CE    +   ++ +  L+ LDL +N + + G+  L
Sbjct: 946  CEALRKPLCNLRCLWLWGCSIPPFSCED---LCSALSCNQSLVTLDLGQNPLGSSGVKML 1002

Query: 423  SLALKVNHSLLR 434
               L  +   LR
Sbjct: 1003 FETLTCSSGTLR 1014



 Score = 65.5 bits (158), Expect = 1e-10
 Identities = 61/212 (28%), Positives = 92/212 (43%), Gaps = 8/212 (3%)

Query: 171  IEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDHSAPFVARALR 229
            +E  +S T +N+S N+ +   G +     +R   C LQ L   N  L + +   +A  L 
Sbjct: 807  LEVNQSLTCVNLSDNELLD-EGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLV 865

Query: 230  IRSSLAVLHLENASLSGRPLMLLATALKM---NMNLRELYLADNKLNGLQDSAQLGNLLK 286
            +   L  L L    +    +  L   L+     +    L+  D   +G  D   L  LL+
Sbjct: 866  VSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCD---LTKLLQ 922

Query: 287  FNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQ 346
               SL  LDL  NH+   G+ ++CE L++    L  L LW   +       L   L   Q
Sbjct: 923  EKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQ 982

Query: 347  SLETLNLGHNPIGNEGVRHLKNGLISNRSVLR 378
            SL TL+LG NP+G+ GV+ L   L  +   LR
Sbjct: 983  SLVTLDLGQNPLGSSGVKMLFETLTCSSGTLR 1014


>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
           sapiens]
          Length = 1061

 Score = 63.5 bits (153), Expect = 5e-10
 Identities = 73/258 (28%), Positives = 111/258 (43%), Gaps = 12/258 (4%)

Query: 184 FNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENA 242
           +   +G+RG +     +R  +C LQ L  +   +   +   ++ AL    +L  + L   
Sbjct: 721 YRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDLSGN 780

Query: 243 SLSGRPLMLLATALKM-NMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHV 301
            +    +MLL   L+     L+ + L   +L       ++ ++L  N  L  LDL  N +
Sbjct: 781 GVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLES-GACQEMASVLGTNPHLVELDLTGNAL 839

Query: 302 LDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNE 361
            D GL  +C+GL+     L TL L   +LT      L  TL   QSL  L+L  N +G+ 
Sbjct: 840 EDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELGDL 899

Query: 362 GVRHLKNGL---ISNRSVLRLGLAST-KLTCEGAVAVAEFIAESPRLLRLDLRENEIKTG 417
           GV  L  GL         LRLG+       CEG   V   +  +  L  LDL  N++   
Sbjct: 900 GVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVV---LQANHNLRELDLSFNDLGDW 956

Query: 418 GLMALSLALKVNHSLLRL 435
           GL  L+  L+  H   RL
Sbjct: 957 GLWLLAEGLQ--HPACRL 972



 Score = 44.3 bits (103), Expect = 3e-04
 Identities = 42/159 (26%), Positives = 70/159 (44%), Gaps = 3/159 (1%)

Query: 278 SAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAF 337
           S  L   L  N +L  L L  N +   G+  +C+GL+     L  L L   +++ +    
Sbjct: 702 SEHLAAALCTNPNLIELSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACED 761

Query: 338 LGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLR-LGLASTKLTCEGAVAVAE 396
           L   L   ++L  ++L  N +G  G+  L  GL   +  L+ + L   +L       +A 
Sbjct: 762 LSAALIANKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMAS 821

Query: 397 FIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRL 435
            +  +P L+ LDL  N ++  GL  L   L+  H + RL
Sbjct: 822 VLGTNPHLVELDLTGNALEDLGLRLLCQGLR--HPVCRL 858



 Score = 43.5 bits (101), Expect = 6e-04
 Identities = 47/144 (32%), Positives = 66/144 (45%), Gaps = 2/144 (1%)

Query: 224  VARALRIRSSLAVLHLENASLSGRPLMLLATALKM-NMNLRELYLADNKLNGLQDSAQLG 282
            +A  L +  SL  L L    L    ++LL   L+     L+ L L   +L G      L 
Sbjct: 876  LASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLGICRL-GSAACEGLS 934

Query: 283  NLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTL 342
             +L+ N +L+ LDL  N + D GL  + EGL+     L  L L +  LT      L  TL
Sbjct: 935  VVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTAKACENLYFTL 994

Query: 343  PHTQSLETLNLGHNPIGNEGVRHL 366
               Q+L  L L +N +G+ GVR L
Sbjct: 995  GINQTLTDLYLTNNALGDTGVRLL 1018



 Score = 36.6 bits (83), Expect = 0.071
 Identities = 52/193 (26%), Positives = 82/193 (42%), Gaps = 11/193 (5%)

Query: 159  LYAQGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLL 217
            L A     L   +   +S   L++S N+ +G  G       +R  +C LQ L      L 
Sbjct: 868  LTAAACDELASTLSVNQSLRELDLSLNE-LGDLGVLLLCEGLRHPTCKLQTLRLGICRLG 926

Query: 218  DHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALKMNM-NLRELYLADNKLNGLQ 276
              +   ++  L+   +L  L L    L    L LLA  L+     L++L+L    L   +
Sbjct: 927  SAACEGLSVVLQANHNLRELDLSFNDLGDWGLWLLAEGLQHPACRLQKLWLDSCGLTA-K 985

Query: 277  DSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLW-----NNQLT 331
                L   L  N +L  L L NN + D+G+  +C+ L     G    VLW      N++T
Sbjct: 986  ACENLYFTLGINQTLTDLYLTNNALGDTGVRLLCKRL--SHPGCKLRVLWLFGMDLNKMT 1043

Query: 332  HTGMAFLGMTLPH 344
            H+ +A L +T P+
Sbjct: 1044 HSRLAALRVTKPY 1056


>gi|34878690 NLR family, pyrin domain containing 3 isoform b [Homo
           sapiens]
          Length = 922

 Score = 63.2 bits (152), Expect = 7e-10
 Identities = 61/191 (31%), Positives = 88/191 (46%), Gaps = 4/191 (2%)

Query: 217 LDHSAPF-VARALRIRSSLAVLHLENASLSGRPLMLLATALK-MNMNLRELYLADNKLNG 274
           L H   F ++  L     L  L L + +L    + LL   LK +  NL++L+L ++ L  
Sbjct: 725 LSHECCFDISLVLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTS 784

Query: 275 LQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTG 334
           +  SA L ++L  N +L  L LR N + D G+  +CEGL      L  L L N  LT   
Sbjct: 785 VCCSA-LSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHC 843

Query: 335 MAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLR-LGLASTKLTCEGAVA 393
              L   L  +QSL  L+LG+N +G+ GV      L     +L+ LGL+      E   A
Sbjct: 844 CWDLSTLLTSSQSLRKLSLGNNDLGDLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSA 903

Query: 394 VAEFIAESPRL 404
           +     E P L
Sbjct: 904 LETLQEEKPEL 914


>gi|4506411 Ran GTPase activating protein 1 [Homo sapiens]
          Length = 587

 Score = 63.2 bits (152), Expect = 7e-10
 Identities = 68/265 (25%), Positives = 105/265 (39%), Gaps = 40/265 (15%)

Query: 328 NQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLT 387
           N + H G+  L         L  +NL  N    +G   +   L + R V  +      + 
Sbjct: 218 NGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVR 277

Query: 388 CEGAVAVAEFIAES-PRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREPKKEAV 446
            +GAVA+A+ I    P+L  L+L   EIK    +A++ A+     L +LDL+        
Sbjct: 278 SKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGN------ 331

Query: 447 KSFIETQKALLAEIQNGCKRNLVLAREREEKEQPPQLSASMPETTATEPQPDDEPAAGVQ 506
            +  E     L E+  G     VLA   +++++  +      E  A E + +DE      
Sbjct: 332 -TLGEEGCEQLQEVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDE------ 384

Query: 507 NGAPSPAPSPDSDSDSDSDGEEEEEEE------GERDETPSGAIDTRDTGSSEP---QPP 557
                         + + + EEEEEEE      GE+  TPS  I   +TG   P    PP
Sbjct: 385 --------------EEEEEEEEEEEEEPQQRGQGEKSATPSRKILDPNTGEPAPVLSSPP 430

Query: 558 PEPPRSGPPLPNGLKPEFALALPPE 582
           P    +    P+   PE  L L P+
Sbjct: 431 PADVSTFLAFPS---PEKLLRLGPK 452



 Score = 53.1 bits (126), Expect = 7e-07
 Identities = 88/388 (22%), Positives = 146/388 (37%), Gaps = 46/388 (11%)

Query: 233 SLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSA-----QLGN-LLK 286
           SL  L LE  ++      ++A AL+    L+  + +D     L+         LG  L+ 
Sbjct: 50  SLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRTEIPPALISLGEGLIT 109

Query: 287 FNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLG------- 339
               L  LDL +N     G+    +G +   K      L   +L + GM   G       
Sbjct: 110 AGAQLVELDLSDNAFGPDGV----QGFEALLKSSACFTLQELKLNNCGMGIGGGKILAAA 165

Query: 340 MTLPHTQS--------LETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGA 391
           +T  H +S        L+    G N + N+G   L        ++  + +    +   G 
Sbjct: 166 LTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGI 225

Query: 392 VAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLD----LDREPKKEAVK 447
            A+A+  A +P L  ++L +N     G +A++  LK    +  ++    L R     A+ 
Sbjct: 226 TALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIA 285

Query: 448 SFIETQKALLAEIQNG---CKRNLVLA-----REREEKEQPPQLSASMPETTATEPQPDD 499
             I      L E+       KR+  LA      ++ E E+      ++ E    + Q   
Sbjct: 286 DAIRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQ--- 342

Query: 500 EPAAGVQNGAPSPAPSPDSDSDSDSDGEEEEEE-EGERDETPSGAIDTRDTGSSEPQPPP 558
           E   G        + S D D + + +GEEEEEE E E +E      +  +    EPQ   
Sbjct: 343 EVLEGFNMAKVLASLSDDEDEEEEEEGEEEEEEAEEEEEEDEEEEEEEEEEEEEEPQQRG 402

Query: 559 EPPRSGPPL-----PNGLKPEFALALPP 581
           +  +S  P      PN  +P   L+ PP
Sbjct: 403 QGEKSATPSRKILDPNTGEPAPVLSSPP 430



 Score = 39.3 bits (90), Expect = 0.011
 Identities = 37/169 (21%), Positives = 68/169 (40%), Gaps = 1/169 (0%)

Query: 202 KTSCLQYLDARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMN 261
           K   L+   A    L +  A  +A A R+  +L  +H+    ++   +  LA A  +N  
Sbjct: 178 KPLALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITALAQAFAVNPL 237

Query: 262 LRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLV 321
           LR + L DN     + +  +   LK    +++++  +  V   G   I + ++     L 
Sbjct: 238 LRVINLNDNTFTE-KGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADAIRGGLPKLK 296

Query: 322 TLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGL 370
            L L   ++       +   +     LE L+L  N +G EG   L+  L
Sbjct: 297 ELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVL 345


>gi|33519450 NLR family, pyrin domain containing 9 [Homo sapiens]
          Length = 991

 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 82/317 (25%), Positives = 128/317 (40%), Gaps = 22/317 (6%)

Query: 111 CLDLKGEKLDYKTCEALEEVFKRLQFKVVDLEQTNLDEDP-----RAEAEP--------- 156
           C+    EKL Y   E          F+++D+E T+LD+       +A A+P         
Sbjct: 608 CISDYNEKLVYWR-ELCSMFITNKNFQILDMENTSLDDPSLAILCKALAQPVCKLRKLIF 666

Query: 157 PNLYAQGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTP 215
            ++Y    S LF  + +      L++ +   +     +     ++   C ++ L      
Sbjct: 667 TSVYFGHDSELFKAVLHNPHLKLLSL-YGTSLSQSDIRHLCETLKHPMCKIEELILGKCD 725

Query: 216 LLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALK-MNMNLRELYLADNKLNG 274
           +       +A  L   S L  L L    L    + LL  ALK  +  L  L L    L  
Sbjct: 726 ISSEVCEDIASVLACNSKLKHLSLVENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTS 785

Query: 275 LQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTG 334
           +   + +  +L  + SL +LDL +N + D+G+A +C  LK     +  L L    LT   
Sbjct: 786 VSCDS-ISEVLLCSKSLSLLDLGSNALEDNGVASLCAALKHPGCSIRELWLMGCFLTSDS 844

Query: 335 MAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLR-LGLASTKLT--CEGA 391
              +   L     L+TL LGHN IG+ GVR L   L      L  LGL +  +T  C   
Sbjct: 845 CKDIAAVLICNGKLKTLKLGHNEIGDTGVRQLCAALQHPHCKLECLGLQTCPITRACCDD 904

Query: 392 VAVAEFIAESPRLLRLD 408
           +A A    ++ R L LD
Sbjct: 905 IAAALIACKTLRSLNLD 921



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 52/194 (26%), Positives = 85/194 (43%), Gaps = 5/194 (2%)

Query: 236 VLHLENASLSGRPLMLLATALKMNM-NLRELYLADNKLNGLQDSAQLGNLLKFNCSLQIL 294
           +L +EN SL    L +L  AL   +  LR+L             ++L   +  N  L++L
Sbjct: 634 ILDMENTSLDDPSLAILCKALAQPVCKLRKLIFTSVYFG---HDSELFKAVLHNPHLKLL 690

Query: 295 DLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLG 354
            L    +  S + ++CE LK     +  L+L    ++      +   L     L+ L+L 
Sbjct: 691 SLYGTSLSQSDIRHLCETLKHPMCKIEELILGKCDISSEVCEDIASVLACNSKLKHLSLV 750

Query: 355 HNPIGNEGVRHLKNGLISNRSVL-RLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENE 413
            NP+ +EG+  L   L  +   L RL L    LT     +++E +  S  L  LDL  N 
Sbjct: 751 ENPLRDEGMTLLCEALKHSHCALERLMLMYCCLTSVSCDSISEVLLCSKSLSLLDLGSNA 810

Query: 414 IKTGGLMALSLALK 427
           ++  G+ +L  ALK
Sbjct: 811 LEDNGVASLCAALK 824


>gi|75709196 NACHT, leucine rich repeat and PYD containing 7 isoform
           2 [Homo sapiens]
          Length = 980

 Score = 60.1 bits (144), Expect = 6e-09
 Identities = 74/266 (27%), Positives = 111/266 (41%), Gaps = 17/266 (6%)

Query: 198 HMMRKTSCLQYLDARN----TPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLA 253
           H+ R T  LQ ++ +N    T   D    F+ +      +LA  H+E      R +ML+ 
Sbjct: 698 HVTRSTCHLQKVEIKNVTPDTAYRDFCLAFIGKKTLTHLTLAG-HIEWE----RTMMLML 752

Query: 254 TALKMNMNLRELYLADNKLNGL----QDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYI 309
             L  N      YL   +L G     +  A+   +LK N SL+ L L  N +LD G   +
Sbjct: 753 CDLLRNHKCNLQYL---RLGGHCATPEQWAEFFYVLKANQSLKHLRLSANVLLDEGAMLL 809

Query: 310 CEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHNPIGNEGVRHLKNG 369
            + +   +  L  L L N +LT      L   L  ++ L  L L  NPIG+ GV+ L  G
Sbjct: 810 YKTMTRPKHFLQMLSLENCRLTEASCKDLAAVLVVSKKLTHLCLAKNPIGDTGVKFLCEG 869

Query: 370 L-ISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKTGGLMALSLALKV 428
           L   +  +  L L    +T  G   ++E + E+  L  LDL  N+I  G  +        
Sbjct: 870 LSYPDCKLQTLVLQQCSITKLGCRYLSEALQEACSLTNLDLSINQIARGLWILCQALENP 929

Query: 429 NHSLLRLDLDREPKKEAVKSFIETQK 454
           N +L  L L        +K  +E  K
Sbjct: 930 NCNLKHLRLKTYETNLEIKKLLEEVK 955


>gi|15193292 NLR family, pyrin domain containing 12 isoform 1 [Homo
           sapiens]
          Length = 287

 Score = 59.3 bits (142), Expect = 1e-08
 Identities = 60/194 (30%), Positives = 87/194 (44%), Gaps = 4/194 (2%)

Query: 175 ESATHLNISFNKHIGTRGWQAAAHMMRKTSC-LQYLDARNTPLLDHSAPFVARALRIRSS 233
           ++ T +++S N  +G  G       +R   C LQ +  R   L   +   +A  L     
Sbjct: 53  KNLTRMDLSGNG-VGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPH 111

Query: 234 LAVLHLENASLSGRPLMLLATALKMNM-NLRELYLADNKLNGLQDSAQLGNLLKFNCSLQ 292
           L  L L   +L    L LL   L+  +  LR L+L   +L       +L + L  N SL+
Sbjct: 112 LVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACD-ELASTLSVNQSLR 170

Query: 293 ILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLN 352
            LDL  N + D G+  +CEGL+     L TL L +  LT      L  TL   Q+L  L 
Sbjct: 171 ELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFTLGINQTLTDLY 230

Query: 353 LGHNPIGNEGVRHL 366
           L +N +G+ GVR L
Sbjct: 231 LTNNALGDTGVRLL 244



 Score = 46.6 bits (109), Expect = 7e-05
 Identities = 46/144 (31%), Positives = 65/144 (45%), Gaps = 1/144 (0%)

Query: 280 QLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLG 339
           ++ ++L  N  L  LDL  N + D GL  +C+GL+     L TL L   +LT      L 
Sbjct: 101 EMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELA 160

Query: 340 MTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLR-LGLASTKLTCEGAVAVAEFI 398
            TL   QSL  L+L  N +G+ GV  L  GL      L+ L L S  LT +    +   +
Sbjct: 161 STLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFTL 220

Query: 399 AESPRLLRLDLRENEIKTGGLMAL 422
             +  L  L L  N +   G+  L
Sbjct: 221 GINQTLTDLYLTNNALGDTGVRLL 244



 Score = 42.4 bits (98), Expect = 0.001
 Identities = 41/141 (29%), Positives = 62/141 (43%), Gaps = 1/141 (0%)

Query: 288 NCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQS 347
           N +L  +DL  N V   G+  +CEGL+  +  L  + L   QL       +   L     
Sbjct: 52  NKNLTRMDLSGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPH 111

Query: 348 LETLNLGHNPIGNEGVRHLKNGLISNRSVLR-LGLASTKLTCEGAVAVAEFIAESPRLLR 406
           L  L+L  N + + G+R L  GL      LR L L   +LT      +A  ++ +  L  
Sbjct: 112 LVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRE 171

Query: 407 LDLRENEIKTGGLMALSLALK 427
           LDL  NE+   G++ L   L+
Sbjct: 172 LDLSLNELGDLGVLLLCEGLR 192



 Score = 35.8 bits (81), Expect = 0.12
 Identities = 48/185 (25%), Positives = 70/185 (37%), Gaps = 36/185 (19%)

Query: 194 QAAAHMMRKTSCLQYLDARNTPLLDHSAPFVARALRIR-SSLAVLHLENASLSGRPLMLL 252
           Q  A ++     L  LD     L D     + + LR     L  L L+   L+      L
Sbjct: 100 QEMASVLGTNPHLVELDLTGNALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDEL 159

Query: 253 ATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDL---------------- 296
           A+ L +N +LREL L+ N+L  L        L    C LQ L L                
Sbjct: 160 ASTLSVNQSLRELDLSLNELGDLGVLLLCEGLRHPTCKLQTLRLDSCGLTAKACENLYFT 219

Query: 297 ------------RNNHVLDSGLAYICEGLKEQRKGLVTLVLW-----NNQLTHTGMAFLG 339
                        NN + D+G+  +C+ L     G    VLW      N++TH+ +A L 
Sbjct: 220 LGINQTLTDLYLTNNALGDTGVRLLCKRL--SHPGCKLRVLWLFGMDLNKMTHSRLAALR 277

Query: 340 MTLPH 344
           +T P+
Sbjct: 278 VTKPY 282


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.312    0.131    0.378 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 28,680,927
Number of Sequences: 37866
Number of extensions: 1743758
Number of successful extensions: 28404
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 521
Number of HSP's successfully gapped in prelim test: 1299
Number of HSP's that attempted gapping in prelim test: 15388
Number of HSP's gapped (non-prelim): 9598
length of query: 625
length of database: 18,247,518
effective HSP length: 108
effective length of query: 517
effective length of database: 14,157,990
effective search space: 7319680830
effective search space used: 7319680830
T: 11
A: 40
X1: 16 ( 7.2 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 42 (21.8 bits)
S2: 65 (29.6 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.


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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.

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