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Search of human proteins with 11140811
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|11140811 cullin 4A isoform 2 [Homo sapiens]
(659 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|57165424 cullin 4A isoform 1 [Homo sapiens] 1311 0.0
gi|11140811 cullin 4A isoform 2 [Homo sapiens] 1311 0.0
gi|121114302 cullin 4B isoform 2 [Homo sapiens] 1138 0.0
gi|121114298 cullin 4B isoform 1 [Homo sapiens] 1138 0.0
gi|4503165 cullin 3 [Homo sapiens] 478 e-135
gi|32307161 cullin 1 [Homo sapiens] 328 7e-90
gi|19482174 cullin 2 [Homo sapiens] 278 1e-74
gi|40254446 Vasopressin-activated calcium-mobilizing receptor-1 ... 227 3e-59
gi|7019327 anaphase-promoting complex subunit 2 [Homo sapiens] 65 2e-10
gi|24307991 p53-associated parkin-like cytoplasmic protein [Homo... 42 0.002
gi|169218008 PREDICTED: similar to anaphase-promoting complex su... 40 0.005
gi|50083279 centrosome protein 4 [Homo sapiens] 40 0.009
gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo s... 38 0.034
gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo sa... 38 0.034
gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Ho... 34 0.49
gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Ho... 34 0.49
gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Ho... 34 0.49
gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Ho... 34 0.49
gi|4506751 restin isoform a [Homo sapiens] 32 1.4
gi|126012497 dynein, axonemal, heavy polypeptide 8 [Homo sapiens] 32 1.4
gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens] 32 1.4
gi|239753136 PREDICTED: hypothetical protein [Homo sapiens] 32 1.9
gi|239747702 PREDICTED: hypothetical protein XP_002348252 [Homo ... 32 1.9
gi|239741569 PREDICTED: hypothetical protein XP_002342240 [Homo ... 32 1.9
gi|163659918 sacsin [Homo sapiens] 32 2.4
gi|4507531 toll-like receptor 3 [Homo sapiens] 31 3.2
gi|222418791 EF-hand calcium binding domain 4B isoform a [Homo s... 31 3.2
gi|155969697 keratin 6C [Homo sapiens] 31 4.1
gi|19115954 dynein, axonemal, heavy chain 5 [Homo sapiens] 31 4.1
gi|119703753 keratin 6B [Homo sapiens] 31 4.1
>gi|57165424 cullin 4A isoform 1 [Homo sapiens]
Length = 759
Score = 1311 bits (3392), Expect = 0.0
Identities = 659/659 (100%), Positives = 659/659 (100%)
Query: 1 MLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTY 60
MLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTY
Sbjct: 101 MLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTY 160
Query: 61 VLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGM 120
VLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGM
Sbjct: 161 VLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGM 220
Query: 121 LSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDH 180
LSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDH
Sbjct: 221 LSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDH 280
Query: 181 STQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHW 240
STQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHW
Sbjct: 281 STQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHW 340
Query: 241 SEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINK 300
SEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINK
Sbjct: 341 SEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINK 400
Query: 301 RPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKR 360
RPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKR
Sbjct: 401 RPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKR 460
Query: 361 LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGP 420
LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGP
Sbjct: 461 LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGP 520
Query: 421 IDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKA 480
IDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKA
Sbjct: 521 IDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKA 580
Query: 481 EFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLI 540
EFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLI
Sbjct: 581 EFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLI 640
Query: 541 KSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAI 600
KSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAI
Sbjct: 641 KSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAI 700
Query: 601 VRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 659
VRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA
Sbjct: 701 VRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 759
>gi|11140811 cullin 4A isoform 2 [Homo sapiens]
Length = 659
Score = 1311 bits (3392), Expect = 0.0
Identities = 659/659 (100%), Positives = 659/659 (100%)
Query: 1 MLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTY 60
MLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTY
Sbjct: 1 MLYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTY 60
Query: 61 VLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGM 120
VLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGM
Sbjct: 61 VLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGM 120
Query: 121 LSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDH 180
LSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDH
Sbjct: 121 LSDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDH 180
Query: 181 STQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHW 240
STQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHW
Sbjct: 181 STQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHW 240
Query: 241 SEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINK 300
SEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINK
Sbjct: 241 SEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINK 300
Query: 301 RPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKR 360
RPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKR
Sbjct: 301 RPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKR 360
Query: 361 LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGP 420
LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGP
Sbjct: 361 LLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGP 420
Query: 421 IDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKA 480
IDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKA
Sbjct: 421 IDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKA 480
Query: 481 EFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLI 540
EFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLI
Sbjct: 481 EFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLI 540
Query: 541 KSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAI 600
KSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAI
Sbjct: 541 KSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAI 600
Query: 601 VRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 659
VRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA
Sbjct: 601 VRIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 659
>gi|121114302 cullin 4B isoform 2 [Homo sapiens]
Length = 895
Score = 1138 bits (2943), Expect = 0.0
Identities = 564/658 (85%), Positives = 613/658 (93%)
Query: 2 LYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYV 61
LYKQLRQ CEDH++AQI FREDSLDSVLFLKKI+ CWQ+HCRQMIMIRSIFLFLDRTYV
Sbjct: 238 LYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYV 297
Query: 62 LQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGML 121
LQNS LPSIWDMGLELFR HIISD+ VQ+KTIDGILLLIERER+GEA+DRSLLRSLL ML
Sbjct: 298 LQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSML 357
Query: 122 SDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHS 181
SDLQ+Y+DSFE +FLEETN LYAAEGQ+LMQEREVPEYL+HV+KRLEEE DR+ITYLD +
Sbjct: 358 SDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQT 417
Query: 182 TQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWS 241
TQK LIA VEKQLLGEHLTAILQKGL++LLDENR+ DL+ +YQLFSRVRGG Q LLQ W
Sbjct: 418 TQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWI 477
Query: 242 EYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKR 301
EYIK FG+ IVINPEKDK MVQ+LLDFKDKVDH+I++CF KNE+F+N MKE+FETFINKR
Sbjct: 478 EYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKR 537
Query: 302 PNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRL 361
PNKPAELIAK+VDSKLRAGNKEATDEELE+ LDKIMI+FRFI+GKDVFEAFYKKDLAKRL
Sbjct: 538 PNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRL 597
Query: 362 LVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPI 421
LVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIM+ FKQ+MQNQ+ G I
Sbjct: 598 LVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNI 657
Query: 422 DLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAE 481
+LTVNILTMGYWPTY PMEVHL PEM+KLQE+FK FYLGKHSGRKLQWQ+TLGH VLKAE
Sbjct: 658 ELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAE 717
Query: 482 FKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIK 541
FKEGKKE QVSLFQTLVLLMFNEG+ FS EEIK ATGIED ELRRTLQSLACGKARVL K
Sbjct: 718 FKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLAK 777
Query: 542 SPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIV 601
+PKGK++EDGDKFI N +FKHKLFRIKINQIQMKETVEEQ STTERVFQDRQYQIDAAIV
Sbjct: 778 NPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIV 837
Query: 602 RIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 659
RIMKMRKTL HNLLVSE+YNQLKFPVKP DLKKRIESLIDRDYMERDK+NPNQY+Y+A
Sbjct: 838 RIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA 895
>gi|121114298 cullin 4B isoform 1 [Homo sapiens]
Length = 913
Score = 1138 bits (2943), Expect = 0.0
Identities = 564/658 (85%), Positives = 613/658 (93%)
Query: 2 LYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYV 61
LYKQLRQ CEDH++AQI FREDSLDSVLFLKKI+ CWQ+HCRQMIMIRSIFLFLDRTYV
Sbjct: 256 LYKQLRQICEDHIKAQIHQFREDSLDSVLFLKKIDRCWQNHCRQMIMIRSIFLFLDRTYV 315
Query: 62 LQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGML 121
LQNS LPSIWDMGLELFR HIISD+ VQ+KTIDGILLLIERER+GEA+DRSLLRSLL ML
Sbjct: 316 LQNSMLPSIWDMGLELFRAHIISDQKVQNKTIDGILLLIERERNGEAIDRSLLRSLLSML 375
Query: 122 SDLQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHS 181
SDLQ+Y+DSFE +FLEETN LYAAEGQ+LMQEREVPEYL+HV+KRLEEE DR+ITYLD +
Sbjct: 376 SDLQIYQDSFEQRFLEETNRLYAAEGQKLMQEREVPEYLHHVNKRLEEEADRLITYLDQT 435
Query: 182 TQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWS 241
TQK LIA VEKQLLGEHLTAILQKGL++LLDENR+ DL+ +YQLFSRVRGG Q LLQ W
Sbjct: 436 TQKSLIATVEKQLLGEHLTAILQKGLNNLLDENRIQDLSLLYQLFSRVRGGVQVLLQQWI 495
Query: 242 EYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKR 301
EYIK FG+ IVINPEKDK MVQ+LLDFKDKVDH+I++CF KNE+F+N MKE+FETFINKR
Sbjct: 496 EYIKAFGSTIVINPEKDKTMVQELLDFKDKVDHIIDICFLKNEKFINAMKEAFETFINKR 555
Query: 302 PNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRL 361
PNKPAELIAK+VDSKLRAGNKEATDEELE+ LDKIMI+FRFI+GKDVFEAFYKKDLAKRL
Sbjct: 556 PNKPAELIAKYVDSKLRAGNKEATDEELEKMLDKIMIIFRFIYGKDVFEAFYKKDLAKRL 615
Query: 362 LVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPI 421
LVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIM+ FKQ+MQNQ+ G I
Sbjct: 616 LVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMIQFKQYMQNQNVPGNI 675
Query: 422 DLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAE 481
+LTVNILTMGYWPTY PMEVHL PEM+KLQE+FK FYLGKHSGRKLQWQ+TLGH VLKAE
Sbjct: 676 ELTVNILTMGYWPTYVPMEVHLPPEMVKLQEIFKTFYLGKHSGRKLQWQSTLGHCVLKAE 735
Query: 482 FKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARVLIK 541
FKEGKKE QVSLFQTLVLLMFNEG+ FS EEIK ATGIED ELRRTLQSLACGKARVL K
Sbjct: 736 FKEGKKELQVSLFQTLVLLMFNEGEEFSLEEIKQATGIEDGELRRTLQSLACGKARVLAK 795
Query: 542 SPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIV 601
+PKGK++EDGDKFI N +FKHKLFRIKINQIQMKETVEEQ STTERVFQDRQYQIDAAIV
Sbjct: 796 NPKGKDIEDGDKFICNDDFKHKLFRIKINQIQMKETVEEQASTTERVFQDRQYQIDAAIV 855
Query: 602 RIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 659
RIMKMRKTL HNLLVSE+YNQLKFPVKP DLKKRIESLIDRDYMERDK+NPNQY+Y+A
Sbjct: 856 RIMKMRKTLSHNLLVSEVYNQLKFPVKPADLKKRIESLIDRDYMERDKENPNQYNYIA 913
>gi|4503165 cullin 3 [Homo sapiens]
Length = 768
Score = 478 bits (1230), Expect = e-135
Identities = 287/702 (40%), Positives = 412/702 (58%), Gaps = 50/702 (7%)
Query: 2 LYKQLRQACEDHVQAQILPFREDSLDSVL--FLKKINTCWQDHCRQMIMIRSIFLFLDRT 59
LY LR+ +H+ ++ RED L+S+ FL+ +N W DH M+MIR I +++DR
Sbjct: 73 LYTGLREVVTEHLINKV---REDVLNSLNNNFLQTLNQAWNDHQTAMVMIRDILMYMDRV 129
Query: 60 YVLQNSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLG 119
YV QN+ + +++++GL +FR ++ ++ +L +I RER GE VDR +R+
Sbjct: 130 YVQQNN-VENVYNLGLIIFRDQVVRYGCIRDHLRQTLLDMIARERKGEVVDRGAIRNACQ 188
Query: 120 MLSDL-----QVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRV 174
ML L VY++ FE FLE + + E Q+ + E Y+ V R+ EE +RV
Sbjct: 189 MLMILGLEGRSVYEEDFEAPFLEMSAEFFQMESQKFLAENSASVYIKKVEARINEEIERV 248
Query: 175 ITYLDHSTQKPLIACVEKQLLGEHLTAILQ---KGLDHLLDENRVPDLAQMYQLFSRVRG 231
+ LD ST++P++ VE++L+ +H+ I++ GL H+L + DL MY+LFSRV
Sbjct: 249 MHCLDKSTEEPIVKVVERELISKHMKTIVEMENSGLVHMLKNGKTEDLGCMYKLFSRVPN 308
Query: 232 GQQALLQHWSEYIKTFGTAIVINPEKDK---DMVQDLLDFKDKVDHVIEVCFQKNERFVN 288
G + + + S Y++ G A+V + K D +Q LLD K + D + F + F
Sbjct: 309 GLKTMCECMSSYLREQGKALVSEEGEGKNPVDYIQGLLDLKSRFDRFLLESFNNDRLFKQ 368
Query: 289 LMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDV 348
+ FE F+N P E ++ +D KL+ G K T++E+E LDK M+LFRF+ KDV
Sbjct: 369 TIAGDFEYFLNLNSRSP-EYLSLFIDDKLKKGVKGLTEQEVETILDKAMVLFRFMQEKDV 427
Query: 349 FEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHF 408
FE +YK+ LA+RLL KS S D+EK+M+SKLK ECG FTSKLEGMF+DM +S M F
Sbjct: 428 FERYYKQHLARRLLTNKSVSDDSEKNMISKLKTECGCQFTSKLEGMFRDMSISNTTMDEF 487
Query: 409 KQHMQNQSDS-GPIDLTVNILTMGYWPTY--TPMEVHLTPEMIKLQEVFKAFYLGKHSGR 465
+QH+Q S G +DLTV +LT GYWPT TP + ++ P E+F+ FYL KHSGR
Sbjct: 488 RQHLQATGVSLGGVDLTVRVLTTGYWPTQSATP-KCNIPPAPRHAFEIFRRFYLAKHSGR 546
Query: 466 KLQWQTTLGHAVLKAEF-----KEGKKE-----------------FQVSLFQTLVLLMFN 503
+L Q +G A L A F KE E QVS FQ +L++FN
Sbjct: 547 QLTLQHHMGSADLNATFYGPVKKEDGSEVGVGGAQVTGSNTRKHILQVSTFQMTILMLFN 606
Query: 504 EGDGFSFEEIKMATGIEDSELRRTLQSLACGK--ARVLIKSPKGKEVEDGDKFIFNGEFK 561
+ ++FEEI+ T I + EL R LQSLACGK RVL K PK KE+E+G F N +F
Sbjct: 607 NREKYTFEEIQQETDIPERELVRALQSLACGKPTQRVLTKEPKSKEIENGHIFTVNDQFT 666
Query: 562 HKLFRIKINQIQMK--ETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSEL 619
KL R+KI + K E+ E+ T ++V DR+++I+AAIVRIMK RK + HN+LV+E+
Sbjct: 667 SKLHRVKIQTVAAKQGESDPERKETRQKVDDDRKHEIEAAIVRIMKSRKKMQHNVLVAEV 726
Query: 620 YNQLK--FPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 659
QLK F P +KKRIE LI+R+Y+ R ++ Y YVA
Sbjct: 727 TQQLKARFLPSPVVIKKRIEGLIEREYLARTPEDRKVYTYVA 768
>gi|32307161 cullin 1 [Homo sapiens]
Length = 776
Score = 328 bits (842), Expect = 7e-90
Identities = 228/698 (32%), Positives = 366/698 (52%), Gaps = 49/698 (7%)
Query: 2 LYKQLRQACEDHVQAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYV 61
LYK+L++ ++++ +L ED +D + LK W+D+ ++ I +L+R +V
Sbjct: 88 LYKRLKEFLKNYL-TNLLKDGEDLMDESV-LKFYTQQWEDYRFSSKVLNGICAYLNRHWV 145
Query: 62 LQNST-----LPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRS 116
+ + I+ + L +R + + + + + +L LIE+ER+GE ++ L+
Sbjct: 146 RRECDEGRKGIYEIYSLALVTWRDCLF--RPLNKQVTNAVLKLIEKERNGETINTRLISG 203
Query: 117 L------LGMLSD--------LQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNH 162
+ LG+ D L VYK+SFE +FL +T Y E +Q+ V EY+
Sbjct: 204 VVQSYVELGLNEDDAFAKGPTLTVYKESFESQFLADTERFYTRESTEFLQQNPVTEYMKK 263
Query: 163 VSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQM 222
RL EE RV YL STQ L E+ L+ +HL I +LLD ++ DL +M
Sbjct: 264 AEARLLEEQRRVQVYLHESTQDELARKCEQVLIEKHLE-IFHTEFQNLLDADKNEDLGRM 322
Query: 223 YQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEK-----DKDMVQDLLDFKDKVDHVIE 277
Y L SR++ G L + +I G A + + K VQ +LD K + ++
Sbjct: 323 YNLVSRIQDGLGELKKLLETHIHNQGLAAIEKCGEAALNDPKMYVQTVLDVHKKYNALVM 382
Query: 278 VCFQKNERFVNLMKESFETFINKRP--------NKPAELIAKHVDSKLRAGNKEATDEEL 329
F + FV + ++ FIN +K EL+A++ DS L+ +K + EL
Sbjct: 383 SAFNNDAGFVAALDKACGRFINNNAVTKMAQSSSKSPELLARYCDSLLKKSSKNPEEAEL 442
Query: 330 ERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTS 389
E TL+++M++F++I KDVF+ FY K LAKRL+ SAS DAE SM+SKLK CG +TS
Sbjct: 443 EDTLNQVMVVFKYIEDKDVFQKFYAKMLAKRLVHQNSASDDAEASMISKLKQACGFEYTS 502
Query: 390 KLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIK 449
KL+ MF+D+ +SKD+ FK+H+ N S+ +D ++ +L+ G WP L E+ +
Sbjct: 503 KLQRMFQDIGVSKDLNEQFKKHLTN-SEPLDLDFSIQVLSSGSWPFQQSCTFALPSELER 561
Query: 450 LQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFS 509
+ F AFY +HSGRKL W L L + + Q S FQ +LL +N D ++
Sbjct: 562 SYQRFTAFYASRHSGRKLTWLYQLSKGELVTNCFKNRYTLQASTFQMAILLQYNTEDAYT 621
Query: 510 FEEIKMATGIEDSELRRTLQSLACGKARVLIKSPKGKEVEDGDK------FIFNGEFKHK 563
+++ +T I+ L + LQ L K+++L+ + V++ + ++ G +K+K
Sbjct: 622 VQQLTDSTQIKMDILAQVLQILL--KSKLLVLEDENANVDEVELKPDTLIKLYLG-YKNK 678
Query: 564 LFRIKINQIQMKETVEEQVSTTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQL 623
R+ IN E +EQ +T + + +DR+ I AAIVRIMKMRK L H L+ E+ QL
Sbjct: 679 KLRVNINVPMKTEQKQEQETTHKNIEEDRKLLIQAAIVRIMKMRKVLKHQQLLGEVLTQL 738
Query: 624 KFPVKP--GDLKKRIESLIDRDYMERDKDNPNQYHYVA 659
KP +KK I+ LI+++Y+ER + Y Y+A
Sbjct: 739 SSRFKPRVPVIKKCIDILIEKEYLERVDGEKDTYSYLA 776
>gi|19482174 cullin 2 [Homo sapiens]
Length = 745
Score = 278 bits (710), Expect = 1e-74
Identities = 188/619 (30%), Positives = 315/619 (50%), Gaps = 29/619 (4%)
Query: 64 NSTLPSIWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSD 123
N L I ++ L+++R ++ +Q+ I +L I+ +R GE ++ ++ ++
Sbjct: 133 NEPLMEIGELALDMWRKLMVEP--LQAILIRMLLREIKNDRGGEDPNQKVIHGVINSFVH 190
Query: 124 LQVYKDSFELKF---------LEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRV 174
++ YK F LKF L ET Y E L+QE +Y+ V RL++E R
Sbjct: 191 VEQYKKKFPLKFYQEIFESPFLTETGEYYKQEASNLLQESNCSQYMEKVLGRLKDEEIRC 250
Query: 175 ITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQ 234
YL S+ +I +++++ +HL L +++ + + D+A MY L V G
Sbjct: 251 RKYLHPSSYTKVIHECQQRMVADHLQ-FLHAECHNIIRQEKKNDMANMYVLLRAVSTGLP 309
Query: 235 ALLQHWSEYIKTFGTAIVINPEKDKD---MVQDLLDFKDKVDHVIEVCFQKNERFVNLMK 291
++Q +I G N ++ V+ +L+ K +I ++ F++ +
Sbjct: 310 HMIQELQNHIHDEGLRATSNLTQENMPTLFVESVLEVHGKFVQLINTVLNGDQHFMSALD 369
Query: 292 ESFETFINKRPNKPA----ELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKD 347
++ + +N R K EL+AK+ D+ L+ K T+ E+E L + +F++I KD
Sbjct: 370 KALTSVVNYREPKSVCKAPELLAKYCDNLLKKSAKGMTENEVEDRLTSFITVFKYIDDKD 429
Query: 348 VFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVH 407
VF+ FY + LAKRL+ G S S+D+E++M++KLK CG FTSKL M+ DM +S D+
Sbjct: 430 VFQKFYARMLAKRLIHGLSMSMDSEEAMINKLKQACGYEFTSKLHRMYTDMSVSADLNNK 489
Query: 408 FKQHMQNQS---DSGPIDLTVNILTMGYWP-TYTPMEVHLTP-EMIKLQEVFKAFYLGKH 462
F ++NQ D G I + +L G WP T P P E+ K ++F+ FY
Sbjct: 490 FNNFIKNQDTVIDLG-ISFQIYVLQAGAWPLTQAPSSTFAIPQELEKSVQMFELFYSQHF 548
Query: 463 SGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDS 522
SGRKL W L +K + V+ +Q VLL FN + S++E++ +T + +
Sbjct: 549 SGRKLTWLHYLCTGEVKMNYLGKPYVAMVTTYQMAVLLAFNNSETVSYKELQDSTQMNEK 608
Query: 523 ELRRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVEEQV 582
EL +T++SL +++ + ++++ F N F K + KI K+T +E
Sbjct: 609 ELTKTIKSLL--DVKMINHDSEKEDIDAESSFSLNMNFSSKRTKFKITTSMQKDTPQEME 666
Query: 583 STTERVFQDRQYQIDAAIVRIMKMRKTLGHNLLVSELYNQLKFPVKP--GDLKKRIESLI 640
T V +DR+ + AAIVRIMK RK L HN L+ E+ +Q + P +KK IE LI
Sbjct: 667 QTRSAVDEDRKMYLQAAIVRIMKARKVLRHNALIQEVISQSRARFNPSISMIKKCIEVLI 726
Query: 641 DRDYMERDKDNPNQYHYVA 659
D+ Y+ER + + ++Y YVA
Sbjct: 727 DKQYIERSQASADEYSYVA 745
>gi|40254446 Vasopressin-activated calcium-mobilizing receptor-1
[Homo sapiens]
Length = 780
Score = 227 bits (578), Expect = 3e-59
Identities = 194/712 (27%), Positives = 348/712 (48%), Gaps = 75/712 (10%)
Query: 15 QAQILPFREDSLDSVLFLKKINTCWQDHCRQMIMIRSIFLFLDRTYV-LQNSTLPS---- 69
QA++L ++D+ LK W+ Q ++ F L+ T + Q S S
Sbjct: 77 QARVLSHQDDTA----LLKAYIVEWRKFFTQCDILPKPFCQLEITLMGKQGSNKKSNVED 132
Query: 70 --IWDMGLELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLL----RSLLGMLSD 123
+ + L+ + I S+ ++++ D + L+ ER GEA D L+ S + + S+
Sbjct: 133 SIVRKLMLDTWNESIFSN--IKNRLQDSAMKLVHAERLGEAFDSQLVIGVRESYVNLCSN 190
Query: 124 ----LQVYKDSFELKFLEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLD 179
LQ+Y+D+FE +L+ T Y + +Q+ V Y+ + +L+EE R + YL+
Sbjct: 191 PEDKLQIYRDNFEKAYLDSTERFYRTQAPSYLQQNGVQNYMKYADAKLKEEEKRALRYLE 250
Query: 180 HSTQ----KPLIACVEKQLLGEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQA 235
+ + L+ C L+ IL + ++ N L M+ L +V G +
Sbjct: 251 TRRECNSVEALMECCVNALVTSFKETILAE-CQGMIKRNETEKLHLMFSLMDKVPNGIEP 309
Query: 236 LLQHWSEYIKTFGTAIVINPEK-----DKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLM 290
+L+ E+I + G A ++ + + V+ LL ++ +++ FQ + RF+
Sbjct: 310 MLKDLEEHIISAGLADMVAAAETITTDSEKYVEQLLTLFNRFSKLVKEAFQDDPRFLTAR 369
Query: 291 KESFETFIN--------------------KRPNKPAELIAKHVDSKLRAG--NKEATDEE 328
++++ +N + +K EL+A + D LR +K+ T EE
Sbjct: 370 DKAYKAVVNDATIFKLELPLKQKGVGLKTQPESKCPELLANYCDMLLRKTPLSKKLTSEE 429
Query: 329 LERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECG--AA 386
+E L +++++ +++ KDVF ++K L +RL++ SA + E++M+ L+ E G A
Sbjct: 430 IEAKLKEVLLVLKYVQNKDVFMRYHKAHLTRRLILDISADSEIEENMVEWLR-EVGMPAD 488
Query: 387 FTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPID-LTVNILTMGYWP-TYTPMEVHLT 444
+ +KL MF+D+++S+D+ FK+ +N + P D + + IL G W + + V L
Sbjct: 489 YVNKLARMFQDIKVSEDLNQAFKEMHKNNKLALPADSVNIKILNAGAWSRSSEKVFVSLP 548
Query: 445 PEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNE 504
E+ L + FY HSGRKL W + + ++ + + G+ + +V+ FQ VL +N+
Sbjct: 549 TELEDLIPEVEEFYKKNHSGRKLHWHHLMSNGIITFKNEVGQYDLEVTTFQLAVLFAWNQ 608
Query: 505 --GDGFSFEEIKMATGIEDSELRRTLQSLACG---KARVLIKSPK---GKEVEDGDKFIF 556
+ SFE +K+AT + D+ELRRTL SL K +VL+ P+ K+ +G F
Sbjct: 609 RPREKISFENLKLATELPDAELRRTLWSLVAFPKLKRQVLLYEPQVNSPKDFTEGTLFSV 668
Query: 557 NGEFK-----HKLFRIKINQIQMKETVEEQV--STTERVFQDRQYQIDAAIVRIMKMRKT 609
N EF R KIN I + E++ E + Q R + AI++IMKMRK
Sbjct: 669 NQEFSLIKNAKVQKRGKINLIGRLQLTTERMREEENEGIVQLRILRTQEAIIQIMKMRKK 728
Query: 610 LGHNLLVSELYNQLK--FPVKPGDLKKRIESLIDRDYMERDKDNPNQYHYVA 659
+ + L +EL LK F + +K++IE LI+ Y+ RD+ + N + Y+A
Sbjct: 729 ISNAQLQTELVEILKNMFLPQKKMIKEQIEWLIEHKYIRRDESDINTFIYMA 780
>gi|7019327 anaphase-promoting complex subunit 2 [Homo sapiens]
Length = 822
Score = 65.5 bits (158), Expect = 2e-10
Identities = 52/200 (26%), Positives = 89/200 (44%), Gaps = 2/200 (1%)
Query: 331 RTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSK 390
R+ D I +L KD+F Y+ LA RLL S S + E + LK G A
Sbjct: 497 RSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHF 556
Query: 391 LEGMFKDMELSKDIMVHFKQHMQNQ--SDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMI 448
E M KDM S+ I + ++ + + + P + IL+ +WP + ++ + ++
Sbjct: 557 CEVMLKDMADSRRINANIREEDEKRPAEEQPPFGVYAVILSSEFWPPFKDEKLEVPEDIR 616
Query: 449 KLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGF 508
E + Y + R L W+ TLG + E + V+ Q ++LL F + +
Sbjct: 617 AALEAYCKKYEQLKAMRTLSWKHTLGLVTMDVELADRTLSVAVTPVQAVILLYFQDQASW 676
Query: 509 SFEEIKMATGIEDSELRRTL 528
+ EE+ A + + LRR +
Sbjct: 677 TLEELSKAVKMPVALLRRRM 696
>gi|24307991 p53-associated parkin-like cytoplasmic protein [Homo
sapiens]
Length = 2517
Score = 42.0 bits (97), Expect = 0.002
Identities = 66/286 (23%), Positives = 121/286 (42%), Gaps = 70/286 (24%)
Query: 289 LMKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDE-----ELERTLDKIMILFRFI 343
L+++SF T + +E A+++D +++ G +L+R L+ IM+L +
Sbjct: 1534 LLQQSFLTAAHM-----SEQFARYIDQQIQGGLIGGAPGVEMLGQLQRHLEPIMVLSG-L 1587
Query: 344 HGKDVFEAFYKKDLAKRLLVGKSASVDA--------------------EKSMLSKLKHEC 383
FE FY+ +A RLL S+ ++ S +L+ +
Sbjct: 1588 ELATTFEHFYQHYMADRLLSFGSSWLEGAVLEQIGLCFPNRLPQLMLQSLSTSEELQRQF 1647
Query: 384 GAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQS---------DSGPIDLTVNILTMGYWP 434
+L+ +F + E ++ + ++ + + D P +++ +L+ WP
Sbjct: 1648 HLFQLQRLDKLFLEQEDEEEKRLEEEEEEEEEEEAEKELFIEDPSPA-ISILVLSPRCWP 1706
Query: 435 T------YTPMEVHLTPEMIKLQEVFKAFY----------LGKHSGRKLQWQTTLGHAVL 478
Y P + L E + F +FY +G H R+LQW T LG
Sbjct: 1707 VSPLCYLYHPRKC-LPTEFCDALDRFSSFYSQSQNHPVLDMGPH--RRLQW-TWLG---- 1758
Query: 479 KAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSEL 524
+AE + GK+ VS Q +LL FN+ EE+ + T ++DS+L
Sbjct: 1759 RAELQFGKQILHVSTVQMWLLLKFNQ-----TEEVSVETLLKDSDL 1799
>gi|169218008 PREDICTED: similar to anaphase-promoting complex
subunit 2 [Homo sapiens]
Length = 430
Score = 40.4 bits (93), Expect = 0.005
Identities = 35/121 (28%), Positives = 56/121 (46%), Gaps = 3/121 (2%)
Query: 331 RTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSKLKHECGAAFTSK 390
R+ D I +L KD+F Y+ LA RLL S S + E + LK G A
Sbjct: 271 RSSDIISLLVSIYGSKDLFINEYRSLLADRLLHQFSFSPEREIRNVELLKLRFGEAPMHF 330
Query: 391 LEGMFKDMELSKDIMVHFKQHMQNQ--SDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMI 448
E M KDM S+ I + ++ + + + P + IL+ +WP + ++ + PE I
Sbjct: 331 CEVMLKDMADSRRINANIREEDEKRPAEEQPPFGVYAVILSSEFWPPFKDEKLEV-PEDI 389
Query: 449 K 449
+
Sbjct: 390 R 390
>gi|50083279 centrosome protein 4 [Homo sapiens]
Length = 1140
Score = 39.7 bits (91), Expect = 0.009
Identities = 88/475 (18%), Positives = 184/475 (38%), Gaps = 103/475 (21%)
Query: 151 MQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHL 210
M E V +Y + R E E +R+ LD +++ + E L A L +D L
Sbjct: 222 MMESGVRDYSKQIELR-EREIERLSVALDGGRSPDVLSLESRNKTNEKLIAHLNIQVDFL 280
Query: 211 LDEN-----RVPDLAQ------------------MYQLFSRVRGGQQALLQHWSEYIKTF 247
N R+ +L + + Q + + Q L +H E ++T
Sbjct: 281 QQANKDLEKRIRELMETKETVTSEVVNLSNKNEKLCQELTEIDQLAQQLERHKEEVLETA 340
Query: 248 GTAIVINPEKDKDMVQDLLDFKD---KVDHVIEVCFQKNERFVN--LMKESFETFINKRP 302
+ ++ K + ++ D ++ K+ + +C ++ ER + L+K ET +++
Sbjct: 341 DKELGEAKKEIKRKLSEMQDLEETMAKLQLELNLCQKEKERLSDELLVKSDLETVVHQLE 400
Query: 303 NKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMI-------------LFRFIHGKDVF 349
+ L +K V+S T+ +L ++++ + L F+ G +
Sbjct: 401 QEKQRL-SKKVESFA------VTERQLTLEVERMRLEHGIKRRDRSPSRLDTFLKGIEEE 453
Query: 350 EAFYKKDLAK--RLLVGKSASVD---AEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDI 404
+YKK+L + ++ +S S EKS + + + + S++ + ++ + + +
Sbjct: 454 RDYYKKELERLQHIIQRRSCSTSYSAREKSSIFRTPEK--GDYNSEIHQITRERDELQRM 511
Query: 405 MVHFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSG 464
+ F+++M+ D+ N+ LT E KL ++ +
Sbjct: 512 LERFEKYME--------DIQSNVKL-------------LTAERDKLSVLYNEAQEELSAL 550
Query: 465 RKLQWQTTLGHAVLKAEFKEGKKEFQVSLFQTLVLLMFNEGDGFSFEEIKMATGIEDSEL 524
RK QTT H ++ +KE +++L ++ E E I+ + SEL
Sbjct: 551 RKESTQTTAPHNIVSLM----EKEKELALSDLRRIMAEKEALREKLEHIEEVSLFGKSEL 606
Query: 525 RRTLQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLFRIKINQIQMKETVE 579
+T++ L C N + + + + +K + MKET+E
Sbjct: 607 EKTIEHLTC----------------------VNHQLESEKYELKSKVLIMKETIE 639
>gi|119466532 laminin alpha 2 subunit isoform b precursor [Homo
sapiens]
Length = 3118
Score = 37.7 bits (86), Expect = 0.034
Identities = 35/149 (23%), Positives = 69/149 (46%), Gaps = 17/149 (11%)
Query: 203 LQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMV 262
LQK +D ++ E R +L ++ +ALL+ + K FG + N E +KD+
Sbjct: 1717 LQKEIDQMIKELRRKNLETQKEIAEDELVAAEALLK---KVKKLFGESRGENEEMEKDLR 1773
Query: 263 QDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPA--------ELIAKHVD 314
+ L D+K+KVD ++ + ++ ++E+ F + N A E + ++
Sbjct: 1774 EKLADYKNKVDDAWDLLREATDK----IREANRLFAVNQKNMTALEKKKEAVESGKRQIE 1829
Query: 315 SKLRAGNKEATDEELERTLDKIMILFRFI 343
+ L+ GN +E R D+I + ++
Sbjct: 1830 NTLKEGNDIL--DEANRLADEINSIIDYV 1856
>gi|28559088 laminin alpha 2 subunit isoform a precursor [Homo
sapiens]
Length = 3122
Score = 37.7 bits (86), Expect = 0.034
Identities = 35/149 (23%), Positives = 69/149 (46%), Gaps = 17/149 (11%)
Query: 203 LQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMV 262
LQK +D ++ E R +L ++ +ALL+ + K FG + N E +KD+
Sbjct: 1717 LQKEIDQMIKELRRKNLETQKEIAEDELVAAEALLK---KVKKLFGESRGENEEMEKDLR 1773
Query: 263 QDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPA--------ELIAKHVD 314
+ L D+K+KVD ++ + ++ ++E+ F + N A E + ++
Sbjct: 1774 EKLADYKNKVDDAWDLLREATDK----IREANRLFAVNQKNMTALEKKKEAVESGKRQIE 1829
Query: 315 SKLRAGNKEATDEELERTLDKIMILFRFI 343
+ L+ GN +E R D+I + ++
Sbjct: 1830 NTLKEGNDIL--DEANRLADEINSIIDYV 1856
>gi|13124879 smooth muscle myosin heavy chain 11 isoform SM1A [Homo
sapiens]
Length = 1972
Score = 33.9 bits (76), Expect = 0.49
Identities = 66/290 (22%), Positives = 116/290 (40%), Gaps = 43/290 (14%)
Query: 136 LEETNCLYAAEGQRLMQEREVP----EYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVE 191
LEE + E + L Q+ E + L RL++E D ++ LD+ Q+ L++ +E
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN--QRQLVSNLE 1447
Query: 192 KQLLGEHLTAILQKGLDHLLDE-----NRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKT 246
K+ Q+ D LL E ++ D + +R + + L E
Sbjct: 1448 KK----------QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1497
Query: 247 FGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPA 306
+ + K ++DL+ KD V + +K++R + E +T + + +
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHE-LEKSKRALETQMEEMKTQLEELED--- 1553
Query: 307 ELIAKHVDSKLRAG-NKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGK 365
EL A D+KLR N +A + ER L +D ++ L ++L +
Sbjct: 1554 ELQATE-DAKLRLEVNMQALKGQFERDLQ----------ARDEQNEEKRRQLQRQLHEYE 1602
Query: 366 SASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQ 415
+ D K + AA KLEG KD+EL D + ++ Q
Sbjct: 1603 TELEDERK------QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ 1646
>gi|92091586 smooth muscle myosin heavy chain 11 isoform SM1B [Homo
sapiens]
Length = 1979
Score = 33.9 bits (76), Expect = 0.49
Identities = 66/290 (22%), Positives = 116/290 (40%), Gaps = 43/290 (14%)
Query: 136 LEETNCLYAAEGQRLMQEREVP----EYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVE 191
LEE + E + L Q+ E + L RL++E D ++ LD+ Q+ L++ +E
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN--QRQLVSNLE 1454
Query: 192 KQLLGEHLTAILQKGLDHLLDE-----NRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKT 246
K+ Q+ D LL E ++ D + +R + + L E
Sbjct: 1455 KK----------QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1504
Query: 247 FGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPA 306
+ + K ++DL+ KD V + +K++R + E +T + + +
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHE-LEKSKRALETQMEEMKTQLEELED--- 1560
Query: 307 ELIAKHVDSKLRAG-NKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGK 365
EL A D+KLR N +A + ER L +D ++ L ++L +
Sbjct: 1561 ELQATE-DAKLRLEVNMQALKGQFERDLQ----------ARDEQNEEKRRQLQRQLHEYE 1609
Query: 366 SASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQ 415
+ D K + AA KLEG KD+EL D + ++ Q
Sbjct: 1610 TELEDERK------QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ 1653
>gi|92091583 smooth muscle myosin heavy chain 11 isoform SM2B [Homo
sapiens]
Length = 1945
Score = 33.9 bits (76), Expect = 0.49
Identities = 66/290 (22%), Positives = 116/290 (40%), Gaps = 43/290 (14%)
Query: 136 LEETNCLYAAEGQRLMQEREVP----EYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVE 191
LEE + E + L Q+ E + L RL++E D ++ LD+ Q+ L++ +E
Sbjct: 1397 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN--QRQLVSNLE 1454
Query: 192 KQLLGEHLTAILQKGLDHLLDE-----NRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKT 246
K+ Q+ D LL E ++ D + +R + + L E
Sbjct: 1455 KK----------QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1504
Query: 247 FGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPA 306
+ + K ++DL+ KD V + +K++R + E +T + + +
Sbjct: 1505 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHE-LEKSKRALETQMEEMKTQLEELED--- 1560
Query: 307 ELIAKHVDSKLRAG-NKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGK 365
EL A D+KLR N +A + ER L +D ++ L ++L +
Sbjct: 1561 ELQATE-DAKLRLEVNMQALKGQFERDLQ----------ARDEQNEEKRRQLQRQLHEYE 1609
Query: 366 SASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQ 415
+ D K + AA KLEG KD+EL D + ++ Q
Sbjct: 1610 TELEDERK------QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ 1653
>gi|13124875 smooth muscle myosin heavy chain 11 isoform SM2A [Homo
sapiens]
Length = 1938
Score = 33.9 bits (76), Expect = 0.49
Identities = 66/290 (22%), Positives = 116/290 (40%), Gaps = 43/290 (14%)
Query: 136 LEETNCLYAAEGQRLMQEREVP----EYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVE 191
LEE + E + L Q+ E + L RL++E D ++ LD+ Q+ L++ +E
Sbjct: 1390 LEEGKKRFQKEIENLTQQYEEKAAAYDKLEKTKNRLQQELDDLVVDLDN--QRQLVSNLE 1447
Query: 192 KQLLGEHLTAILQKGLDHLLDE-----NRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKT 246
K+ Q+ D LL E ++ D + +R + + L E
Sbjct: 1448 KK----------QRKFDQLLAEEKNISSKYADERDRAEAEAREKETKALSLARALEEALE 1497
Query: 247 FGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPA 306
+ + K ++DL+ KD V + +K++R + E +T + + +
Sbjct: 1498 AKEELERTNKMLKAEMEDLVSSKDDVGKNVHE-LEKSKRALETQMEEMKTQLEELED--- 1553
Query: 307 ELIAKHVDSKLRAG-NKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGK 365
EL A D+KLR N +A + ER L +D ++ L ++L +
Sbjct: 1554 ELQATE-DAKLRLEVNMQALKGQFERDLQ----------ARDEQNEEKRRQLQRQLHEYE 1602
Query: 366 SASVDAEKSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMVHFKQHMQNQ 415
+ D K + AA KLEG KD+EL D + ++ Q
Sbjct: 1603 TELEDERK------QRALAAAAKKKLEGDLKDLELQADSAIKGREEAIKQ 1646
>gi|4506751 restin isoform a [Homo sapiens]
Length = 1427
Score = 32.3 bits (72), Expect = 1.4
Identities = 111/529 (20%), Positives = 202/529 (38%), Gaps = 78/529 (14%)
Query: 153 EREVPEYLNHVSK----------RLEEEGDRVITYLDHSTQKPL----IACVEKQLLGEH 198
+RE E LN + + R+EEE IT D TQ L I +E+ LL E
Sbjct: 421 DREKVELLNQLEEEKRKVEDLQFRVEEES---ITKGDLETQTKLEHARIKELEQSLLFEK 477
Query: 199 LTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKD 258
A L L++ RV +++ SR+ ++ L E + P D
Sbjct: 478 TKA---DKLQRELEDTRVATVSEK----SRIMELEKDLALRVQEVAELRRRLESNKPAGD 530
Query: 259 KDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDSKLR 318
DM LL + +EV ++R + +KE F + E+ A + ++
Sbjct: 531 VDMSLSLLQEISSLQEKLEVTRTDHQREITSLKEHFGA---REETHQKEIKALYTATEKL 587
Query: 319 AGNKEATDEELERTLDKIMILFRFIHGKDVFEAFYKKDLAKRLLVGKSASVDAEKSMLSK 378
+ E+ +LE + DV A +K L + + A + + S
Sbjct: 588 SKENESLKSKLEHANKE---------NSDVI-ALWKSKLETAIASHQQAMEELKVSFSKG 637
Query: 379 LKHECG--AAFTSKLEGMFKDMELSKDIMVHFKQHMQNQSDSGPIDLTVNILTMGYWPTY 436
L E A +++E M D + H +++QNQ DS + +
Sbjct: 638 LGTETAEFAELKTQIEKMRLDYQ-------HEIENLQNQQDSERAAHAKEMEALRAKLMK 690
Query: 437 TPMEVHLTPEMIKLQEVFKAFYLGKHSGRKLQWQTTLGHAVLKAEFKEGKKEFQVSLF-- 494
E + E I+ + L K + L + + +AE K KE +V
Sbjct: 691 VIKEKENSLEAIRSK-------LDKAEDQHLVEMEDTLNKLQEAEIKV--KELEVLQAKC 741
Query: 495 --QTLVL------LMFNEGDGFSFEEIKMATGIEDSELRRTLQSLACGKARV----LIKS 542
QT V+ L E + ++ A+ SE+++ Q L + ++ + K+
Sbjct: 742 NEQTKVIDNFTSQLKATEEKLLDLDALRKASSEGKSEMKKLRQQLEAAEKQIKHLEIEKN 801
Query: 543 PKGKEVEDGDKFIFNGEFKHKLFRIKINQI-QMKETVEEQVSTTERVFQDRQYQIDAAIV 601
+ + + + E K + ++++ Q+KET+E+++ + F + + A+
Sbjct: 802 AESSKASSITRELQGRELKLTNLQENLSEVSQVKETLEKELQILKEKFAEAS---EEAVS 858
Query: 602 RIMKMRKTLGHNLLVSELYNQLKFPVKPGDLKKRIESLIDRDYMERDKD 650
M++T+ E +N L DL+K E+L D + R+KD
Sbjct: 859 VQRSMQETVNKLHQKEEQFNMLS-----SDLEKLRENLADMEAKFREKD 902
>gi|126012497 dynein, axonemal, heavy polypeptide 8 [Homo sapiens]
Length = 4490
Score = 32.3 bits (72), Expect = 1.4
Identities = 39/155 (25%), Positives = 69/155 (44%), Gaps = 14/155 (9%)
Query: 230 RGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNL 289
R ++AL+ S ++ + IV + E + +V+ + F D V E FQ+ R ++
Sbjct: 2980 RWPREALIAVASYFLSDYN--IVCSSEIKRQVVETMGLFHDMVSESCESYFQRYRRRAHV 3037
Query: 290 MKESFETFINKRPNKPAELIAKHVDSKLRAGNKEATDEELERTLDKIMILFRFIHGKDVF 349
+S+ +FIN N AE K++ N++A E + LDK+M +
Sbjct: 3038 TPKSYLSFINGYKNIYAE--------KVKFINEQA--ERMNIGLDKLMEASESVAKLSQD 3087
Query: 350 EAFYKKDLAKRLLVGKS--ASVDAEKSMLSKLKHE 382
A +K+LA + A V +K+K+E
Sbjct: 3088 LAVKEKELAVASIKADEVLAEVTVSAQASAKIKNE 3122
>gi|170016061 spectrin, beta, non-erythrocytic 5 [Homo sapiens]
Length = 3639
Score = 32.3 bits (72), Expect = 1.4
Identities = 33/141 (23%), Positives = 62/141 (43%), Gaps = 24/141 (17%)
Query: 528 LQSLACGKARVLIKSPKGKEVEDGDKFIFNGEFKHKLF-RIKINQIQMKETVEEQVSTTE 586
L+ + + L S G VE+ ++ I KH++F ++ Q + + + E++ T
Sbjct: 2026 LEEILAAQEVSLKTSALGSSVEEVEQLIR----KHEVFLKVLTAQDKKEAALRERLKTLR 2081
Query: 587 RV-FQDRQYQIDAAIVRIMKMRKTLGHNLLVSELY------------------NQLKFPV 627
R +DR + +R+ ++ ++ GH L S L QLK PV
Sbjct: 2082 RPRVRDRLPILLQRRMRVKELAESRGHALHASLLMASFTQAATQAEDWIQAWAQQLKEPV 2141
Query: 628 KPGDLKKRIESLIDRDYMERD 648
PGDL+ +++ L+ E +
Sbjct: 2142 PPGDLRDKLKPLLKHQAFEAE 2162
>gi|239753136 PREDICTED: hypothetical protein [Homo sapiens]
Length = 136
Score = 32.0 bits (71), Expect = 1.9
Identities = 20/55 (36%), Positives = 26/55 (47%), Gaps = 7/55 (12%)
Query: 489 FQVSLFQTLVLLMFNEGDGFSFEEIKMATGIED-------SELRRTLQSLACGKA 536
FQV + L+ + EG GF E I + TG ED + LQ ACG+A
Sbjct: 21 FQVCYRCDVPLIFYGEGTGFHHERINVLTGAEDQTEASSHTSTSLYLQPEACGRA 75
>gi|239747702 PREDICTED: hypothetical protein XP_002348252 [Homo
sapiens]
Length = 136
Score = 32.0 bits (71), Expect = 1.9
Identities = 20/55 (36%), Positives = 26/55 (47%), Gaps = 7/55 (12%)
Query: 489 FQVSLFQTLVLLMFNEGDGFSFEEIKMATGIED-------SELRRTLQSLACGKA 536
FQV + L+ + EG GF E I + TG ED + LQ ACG+A
Sbjct: 21 FQVCYRCDVPLIFYGEGTGFHHERINVLTGAEDQTEASSHTSTSLYLQPEACGRA 75
>gi|239741569 PREDICTED: hypothetical protein XP_002342240 [Homo
sapiens]
Length = 136
Score = 32.0 bits (71), Expect = 1.9
Identities = 20/55 (36%), Positives = 26/55 (47%), Gaps = 7/55 (12%)
Query: 489 FQVSLFQTLVLLMFNEGDGFSFEEIKMATGIED-------SELRRTLQSLACGKA 536
FQV + L+ + EG GF E I + TG ED + LQ ACG+A
Sbjct: 21 FQVCYRCDVPLIFYGEGTGFHHERINVLTGAEDQTEASSHTSTSLYLQPEACGRA 75
>gi|163659918 sacsin [Homo sapiens]
Length = 4579
Score = 31.6 bits (70), Expect = 2.4
Identities = 30/122 (24%), Positives = 62/122 (50%), Gaps = 22/122 (18%)
Query: 153 EREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLLGEHLTAILQKGLDHLLD 212
E ++PE+L + ++L G V+ LD S Q PLI +K + +A+LQ
Sbjct: 833 EAQLPEFLADIVQKL---GGFVLKKLDASIQHPLI---KKYIHSPLPSAVLQ-------- 878
Query: 213 ENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINPEKDKDMVQDLLDFKDKV 272
+ + + +L +++ +LL + ++ F ++ + EK+K ++Q+L FK ++
Sbjct: 879 ---IMEKMPLQKLCNQIT----SLLPTHKDALRKFLASLTDSSEKEKRIIQELAIFK-RI 930
Query: 273 DH 274
+H
Sbjct: 931 NH 932
>gi|4507531 toll-like receptor 3 [Homo sapiens]
Length = 904
Score = 31.2 bits (69), Expect = 3.2
Identities = 24/96 (25%), Positives = 44/96 (45%), Gaps = 7/96 (7%)
Query: 250 AIVINPEKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFIN--KRPNKPAE 307
A +I+ KDKD V + +K D ++ C ++ + + + E +N KR K
Sbjct: 758 AYIIHAYKDKDWVWEHFSSMEKEDQSLKFCLEERDFEAGVFE--LEAIVNSIKRSRKIIF 815
Query: 308 LIAKHVDSK---LRAGNKEATDEELERTLDKIMILF 340
+I H+ R A + +E+ LD I+++F
Sbjct: 816 VITHHLLKDPLCKRFKVHHAVQQAIEQNLDSIILVF 851
>gi|222418791 EF-hand calcium binding domain 4B isoform a [Homo
sapiens]
Length = 731
Score = 31.2 bits (69), Expect = 3.2
Identities = 55/258 (21%), Positives = 102/258 (39%), Gaps = 27/258 (10%)
Query: 76 ELFRTHIISDKMVQSKTIDGILLLIERERSGEAVDRSLLRSLLGMLSDLQVYKDSFELKF 135
E F T IIS + + + ++R+ + A D + M ++ K+ F LK
Sbjct: 198 EDFLTRIISQLQEAHEEKNELECALKRKIA--AYDEEIQHLYEEMEQQIKSEKEQFLLKD 255
Query: 136 LEETNCLYAAEGQRLMQEREVPEYLNHVSKRLEEEGDRVITYLDHSTQKPLIACVEKQLL 195
E Q+L+ + + E L KRLE + T L H + + +L
Sbjct: 256 TERFQARSQELEQKLLCKEQELEQLTQKQKRLEGQ----CTALHHDKHETKAENTKLKLT 311
Query: 196 GEHLTAILQKGLDHLLDENRVPDLAQMYQLFSRVRGGQQALLQHWSEYIKTFGTAIVINP 255
+ L L++ L D + + Q Q+A H + ++ + +
Sbjct: 312 NQELARELERTSWELQDAQQQLESLQ-----------QEACKLHQEKEMEVYRVTESLQR 360
Query: 256 EKDKDMVQDLLDF-KDKVDHV---IEVCFQKNERFVNLMKESFETFINKRPNKPAELIAK 311
EK + Q LDF +++ H+ ++CFQKN+ K + + +I K
Sbjct: 361 EKAGLLKQ--LDFLRERNKHLRDERDICFQKNK----AAKANTAASRASWKKRSGSVIGK 414
Query: 312 HVDSKLRAGNKEATDEEL 329
+VDS+ ++ +EE+
Sbjct: 415 YVDSRGILRSQSEEEEEV 432
>gi|155969697 keratin 6C [Homo sapiens]
Length = 564
Score = 30.8 bits (68), Expect = 4.1
Identities = 36/189 (19%), Positives = 80/189 (42%), Gaps = 32/189 (16%)
Query: 353 YKKDLAKRL--LVGKSASVDAE----KSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMV 406
Y +L ++L +VG+ +D+E + ++ LK++ + + + L KD+
Sbjct: 217 YINNLRRQLDSIVGERGRLDSELRNMQDLVEDLKNKYEDEINKRTAAENEFVTLKKDVDA 276
Query: 407 HFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRK 466
+ ++ Q+ + + +N L Y + M+ H++ + L + R
Sbjct: 277 AYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSV---------VLSMDNNRN 327
Query: 467 LQWQTTLGHAVLKAEFKEGKKEFQV---SLFQTLVLLMFNEGDGFSFEEIKMATGIEDSE 523
L + + A +KA+++E + + S +QT +EE+++ G +
Sbjct: 328 LDLDSII--AEVKAQYEEIAQRSRAEAESWYQT------------KYEELQVTAGRHGDD 373
Query: 524 LRRTLQSLA 532
LR T Q +A
Sbjct: 374 LRNTKQEIA 382
>gi|19115954 dynein, axonemal, heavy chain 5 [Homo sapiens]
Length = 4624
Score = 30.8 bits (68), Expect = 4.1
Identities = 31/136 (22%), Positives = 60/136 (44%), Gaps = 5/136 (3%)
Query: 256 EKDKDMVQDLLDFKDKVDHVIEVCFQKNERFVNLMKESFETFINKRPNKPAELIAKHVDS 315
E K++VQ + F+D V FQ+ R ++ +S+ +FI E KHV+
Sbjct: 3140 EIKKEVVQCMGSFQDGVAEKCVDYFQRFRRSTHVTPKSYLSFIQGYKFIYGE---KHVEV 3196
Query: 316 KLRAGNKEATDEELERTLDKIMILFRFIHG--KDVFEAFYKKDLAKRLLVGKSASVDAEK 373
+ A E+L+ + + L + + K++ A K D+ + + K+ + + K
Sbjct: 3197 RTLANRMNTGLEKLKEASESVAALSKELEAKEKELQVANDKADMVLKEVTMKAQAAEKVK 3256
Query: 374 SMLSKLKHECGAAFTS 389
+ + K+K A S
Sbjct: 3257 AEVQKVKDRAQAIVDS 3272
>gi|119703753 keratin 6B [Homo sapiens]
Length = 564
Score = 30.8 bits (68), Expect = 4.1
Identities = 36/189 (19%), Positives = 80/189 (42%), Gaps = 32/189 (16%)
Query: 353 YKKDLAKRL--LVGKSASVDAE----KSMLSKLKHECGAAFTSKLEGMFKDMELSKDIMV 406
Y +L ++L +VG+ +D+E + ++ LK++ + + + L KD+
Sbjct: 217 YINNLRRQLDNIVGERGRLDSELRNMQDLVEDLKNKYEDEINKRTAAENEFVTLKKDVDA 276
Query: 407 HFKQHMQNQSDSGPIDLTVNILTMGYWPTYTPMEVHLTPEMIKLQEVFKAFYLGKHSGRK 466
+ ++ Q+ + + +N L Y + M+ H++ + L + R
Sbjct: 277 AYMNKVELQAKADTLTDEINFLRALYDAELSQMQTHISDTSV---------VLSMDNNRN 327
Query: 467 LQWQTTLGHAVLKAEFKEGKKEFQV---SLFQTLVLLMFNEGDGFSFEEIKMATGIEDSE 523
L + + A +KA+++E + + S +QT +EE+++ G +
Sbjct: 328 LDLDSII--AEVKAQYEEIAQRSRAEAESWYQT------------KYEELQITAGRHGDD 373
Query: 524 LRRTLQSLA 532
LR T Q +A
Sbjct: 374 LRNTKQEIA 382
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.321 0.137 0.392
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 22,363,164
Number of Sequences: 37866
Number of extensions: 948136
Number of successful extensions: 2881
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 10
Number of HSP's successfully gapped in prelim test: 38
Number of HSP's that attempted gapping in prelim test: 2821
Number of HSP's gapped (non-prelim): 70
length of query: 659
length of database: 18,247,518
effective HSP length: 109
effective length of query: 550
effective length of database: 14,120,124
effective search space: 7766068200
effective search space used: 7766068200
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.9 bits)
S2: 65 (29.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.