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Search of human proteins with 110825984
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110825984 malignant fibrous histiocytoma amplified sequence
1 [Homo sapiens]
(1052 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110825984 malignant fibrous histiocytoma amplified sequence 1... 2112 0.0
gi|122937315 leucine-rich repeats and IQ motif containing 4 [Hom... 166 1e-40
gi|238908508 leucine-rich repeat and death domain-containing pro... 155 2e-37
gi|95113664 leucine rich repeat containing 1 [Homo sapiens] 151 4e-36
gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens] 150 5e-36
gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens] 150 5e-36
gi|45827729 scribble isoform b [Homo sapiens] 147 5e-35
gi|45827731 scribble isoform a [Homo sapiens] 147 5e-35
gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens] 143 7e-34
gi|225579152 insulin-like growth factor binding protein, acid la... 140 5e-33
gi|4826772 insulin-like growth factor binding protein, acid labi... 140 5e-33
gi|21361633 leucine rich repeat containing 40 [Homo sapiens] 139 2e-32
gi|16904383 leucine rich repeat containing 7 [Homo sapiens] 138 2e-32
gi|4503743 flightless I homolog [Homo sapiens] 131 4e-30
gi|171846278 leucine-rich repeat kinase 2 [Homo sapiens] 127 6e-29
gi|90991702 leucine-rich repeat kinase 1 [Homo sapiens] 126 1e-28
gi|157743290 leucine rich repeat containing 30 [Homo sapiens] 120 7e-27
gi|153792305 leucine rich repeat containing 58 [Homo sapiens] 119 1e-26
gi|4758460 glycoprotein V (platelet) [Homo sapiens] 115 2e-25
gi|223005922 leucine rich repeat containing 10-like [Homo sapiens] 113 8e-25
gi|205277468 leucine rich repeat containing 15 isoform a [Homo s... 112 1e-24
gi|18677767 leucine rich repeat containing 15 isoform b [Homo sa... 112 1e-24
gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens] 108 3e-23
gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens] 107 6e-23
gi|40217803 leucine rich repeat containing 8 family, member E [H... 107 6e-23
gi|30181233 leucine-rich repeats and calponin homology (CH) doma... 107 8e-23
gi|21389431 leucine rich repeat containing 39 [Homo sapiens] 106 1e-22
gi|197333706 leucine rich repeat containing 8 family, member D [... 103 7e-22
gi|34222199 leucine rich repeat containing 8 family, member D [H... 103 7e-22
gi|61742786 leucine rich repeat and death domain containing prot... 102 2e-21
>gi|110825984 malignant fibrous histiocytoma amplified sequence 1
[Homo sapiens]
Length = 1052
Score = 2112 bits (5471), Expect = 0.0
Identities = 1052/1052 (100%), Positives = 1052/1052 (100%)
Query: 1 MAGMDSGNLKTARLWRDAALRARKLRSNLRQLTLTAAGACPGAGADALESPASPQLVLPA 60
MAGMDSGNLKTARLWRDAALRARKLRSNLRQLTLTAAGACPGAGADALESPASPQLVLPA
Sbjct: 1 MAGMDSGNLKTARLWRDAALRARKLRSNLRQLTLTAAGACPGAGADALESPASPQLVLPA 60
Query: 61 NLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSH 120
NLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSH
Sbjct: 61 NLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSH 120
Query: 121 NRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCL 180
NRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCL
Sbjct: 121 NRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCL 180
Query: 181 SRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELG 240
SRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELG
Sbjct: 181 SRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELG 240
Query: 241 TLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEE 300
TLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEE
Sbjct: 241 TLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEE 300
Query: 301 LYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDH 360
LYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDH
Sbjct: 301 LYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDH 360
Query: 361 FGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLLLMGHKAA 420
FGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLLLMGHKAA
Sbjct: 361 FGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLLLMGHKAA 420
Query: 421 GKTLLRHCLTEERVEGCPGGGDKEKCYPPSPPPVSKGIEVTSWTADASRGLRFIVYDLAG 480
GKTLLRHCLTEERVEGCPGGGDKEKCYPPSPPPVSKGIEVTSWTADASRGLRFIVYDLAG
Sbjct: 421 GKTLLRHCLTEERVEGCPGGGDKEKCYPPSPPPVSKGIEVTSWTADASRGLRFIVYDLAG 480
Query: 481 DESYEVIQPFFLSPGALYVLVVNLATYEPRHFPTTVGSFLHRVGARVPHAVVCIVGTHAD 540
DESYEVIQPFFLSPGALYVLVVNLATYEPRHFPTTVGSFLHRVGARVPHAVVCIVGTHAD
Sbjct: 481 DESYEVIQPFFLSPGALYVLVVNLATYEPRHFPTTVGSFLHRVGARVPHAVVCIVGTHAD 540
Query: 541 LCGERELEEKCLDIHRQIALQEKHDAEGLSRLAKVVDEALARDFELRSASPHAAYYGVSD 600
LCGERELEEKCLDIHRQIALQEKHDAEGLSRLAKVVDEALARDFELRSASPHAAYYGVSD
Sbjct: 541 LCGERELEEKCLDIHRQIALQEKHDAEGLSRLAKVVDEALARDFELRSASPHAAYYGVSD 600
Query: 601 KNLRRRKAHFQYLLNHRLQILSPVLPVSCRDPRHLRRLRDKLLSVAEHREIFPNLHRVLP 660
KNLRRRKAHFQYLLNHRLQILSPVLPVSCRDPRHLRRLRDKLLSVAEHREIFPNLHRVLP
Sbjct: 601 KNLRRRKAHFQYLLNHRLQILSPVLPVSCRDPRHLRRLRDKLLSVAEHREIFPNLHRVLP 660
Query: 661 RSWQVLEELHFQPPQAQRLWLSWWDSARLGLQAGLTEDRLQSALSYLHESGKLLYFEDSP 720
RSWQVLEELHFQPPQAQRLWLSWWDSARLGLQAGLTEDRLQSALSYLHESGKLLYFEDSP
Sbjct: 661 RSWQVLEELHFQPPQAQRLWLSWWDSARLGLQAGLTEDRLQSALSYLHESGKLLYFEDSP 720
Query: 721 ALKEHVFHNLTRLIDILNVFFQRDPSLLLHKLLLGTSGEGKAEGESSPPMARSTPSQELL 780
ALKEHVFHNLTRLIDILNVFFQRDPSLLLHKLLLGTSGEGKAEGESSPPMARSTPSQELL
Sbjct: 721 ALKEHVFHNLTRLIDILNVFFQRDPSLLLHKLLLGTSGEGKAEGESSPPMARSTPSQELL 780
Query: 781 RATQLHQYVEGFLLHGLLPAHVIRLLLKPHVQAQQDLQLLLELLEKMGLCYCLNKPKGKP 840
RATQLHQYVEGFLLHGLLPAHVIRLLLKPHVQAQQDLQLLLELLEKMGLCYCLNKPKGKP
Sbjct: 781 RATQLHQYVEGFLLHGLLPAHVIRLLLKPHVQAQQDLQLLLELLEKMGLCYCLNKPKGKP 840
Query: 841 LNGSTAWYKFPCYVQNEVPHAEAWINGTNLAGQSFVAEQLQIEYSFPFTFPLGLFARYSV 900
LNGSTAWYKFPCYVQNEVPHAEAWINGTNLAGQSFVAEQLQIEYSFPFTFPLGLFARYSV
Sbjct: 841 LNGSTAWYKFPCYVQNEVPHAEAWINGTNLAGQSFVAEQLQIEYSFPFTFPLGLFARYSV 900
Query: 901 QINSHVVHRSDGKFQIFAYRGKVPVVVSYRPARGVLQPDTLSIASHASLPNIWTAWQAIT 960
QINSHVVHRSDGKFQIFAYRGKVPVVVSYRPARGVLQPDTLSIASHASLPNIWTAWQAIT
Sbjct: 901 QINSHVVHRSDGKFQIFAYRGKVPVVVSYRPARGVLQPDTLSIASHASLPNIWTAWQAIT 960
Query: 961 PLVEELNVLLQEWPGLHYTVHILCSKCLKRGSPNPHAFPGELLSQPRPEGVAEIICPKNG 1020
PLVEELNVLLQEWPGLHYTVHILCSKCLKRGSPNPHAFPGELLSQPRPEGVAEIICPKNG
Sbjct: 961 PLVEELNVLLQEWPGLHYTVHILCSKCLKRGSPNPHAFPGELLSQPRPEGVAEIICPKNG 1020
Query: 1021 SERVNVALVYPPTPTVISPCSKKNVGEKHRNQ 1052
SERVNVALVYPPTPTVISPCSKKNVGEKHRNQ
Sbjct: 1021 SERVNVALVYPPTPTVISPCSKKNVGEKHRNQ 1052
>gi|122937315 leucine-rich repeats and IQ motif containing 4 [Homo
sapiens]
Length = 560
Score = 166 bits (419), Expect = 1e-40
Identities = 119/369 (32%), Positives = 186/369 (50%), Gaps = 29/369 (7%)
Query: 56 LVLPANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTE 115
+V+ NL +E L L N L+ +P+ + + LR + L+RN+F P + L + L
Sbjct: 135 VVIFKNLHHLELLGLTGNHLKCLPKEIVNQT-KLREIYLKRNQFEVFPQELCVL-YTLEI 192
Query: 116 LDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPD 175
+D+ N++ A+ E+ L L+K ++ N LP LPA L + L LD+S N L +P
Sbjct: 193 IDLDENKIGAIPEEI-GHLTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPK 251
Query: 176 SLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLS 235
S + L ++ + + N+L PR + + +L L + + L L L L+ L LS
Sbjct: 252 SFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLYLGNTGLHRLRGSFRCLVNLRFLDLS 311
Query: 236 GAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPL 295
L P C L +LE L LD+N + LP++ L +LK+L L+ N F FP +L L
Sbjct: 312 QNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELGSLSKLKILGLTGNEFLSFPEEVLSL 371
Query: 296 AGLEELYLSRNQ---LTSVPSLISGLGRLLTLWLDNNRIRYLP----------------- 335
A LE+LY+ ++Q LT VP I L L L+++NN + YLP
Sbjct: 372 ASLEKLYIGQDQGFKLTYVPEHIRKLQSLKELYIENNHLEYLPVSLGSMPNLEVLDCRHN 431
Query: 336 ------DSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGI 389
D+I + L+EL L+ N + LP++ L + + + DNP+ +PP EVC +G
Sbjct: 432 LLKQLPDAICQAQALKELRLEDNLLTHLPENLDSLVNLKVLTLMDNPMEEPPKEVCAEGN 491
Query: 390 PYIAAYQKE 398
I Y KE
Sbjct: 492 EAIWKYLKE 500
Score = 155 bits (393), Expect = 1e-37
Identities = 104/322 (32%), Positives = 163/322 (50%), Gaps = 3/322 (0%)
Query: 64 DIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRL 123
++E ++L NN +EE+P+ + L ++RVL L +N L PA+ L L LD+S+N +
Sbjct: 49 ELEEVHLENNQIEEIPQEI-QRLKNIRVLYLDKNNLRSLCPALGLLSS-LESLDLSYNPI 106
Query: 124 TALGAEVVSALRELRKLNLSHNQLPALPAQLGA-LAHLEELDVSFNRLAHLPDSLSCLSR 182
+ VVS L LR+L L L +P + L HLE L ++ N L LP + ++
Sbjct: 107 FSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTK 166
Query: 183 LRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTL 242
LR + + NQ FP++L L LE +D+ N++ +PE+I L L+ +++ L L
Sbjct: 167 LREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVL 226
Query: 243 PAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELY 302
PA C+ + L L L +N L ++P F+ L+++ + LS N E+ P + L LY
Sbjct: 227 PASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLY 286
Query: 303 LSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFG 362
L L + L L L L N + + P I L LE L L N+I LP G
Sbjct: 287 LGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELG 346
Query: 363 QLSRVGLWKIKDNPLIQPPYEV 384
LS++ + + N + P EV
Sbjct: 347 SLSKLKILGLTGNEFLSFPEEV 368
Score = 102 bits (254), Expect = 2e-21
Identities = 86/309 (27%), Positives = 142/309 (45%), Gaps = 8/309 (2%)
Query: 113 LTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAH 172
L E+ + +N++ + E+ L+ +R L L N L +L LG L+ LE LD+S+N +
Sbjct: 50 LEEVHLENNQIEEIPQEI-QRLKNIRVLYLDKNNLRSLCPALGLLSSLESLDLSYNPI-- 106
Query: 173 LPDSL---SCLSRLRTLDVDHNQLTAFPRQLLQ-LVALEELDVSSNRLRGLPEDISALRA 228
SL S L LR L + L P + + L LE L ++ N L+ LP++I
Sbjct: 107 FSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGLTGNHLKCLPKEIVNQTK 166
Query: 229 LKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEF 288
L+ ++L + P C L +LE + LD N + A+P + L L+ ++SN
Sbjct: 167 LREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGHLTGLQKFYMASNNLPVL 226
Query: 289 PAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELV 348
PA+L + L L LS N L S+P + L ++ + L NR+ +P I T L L
Sbjct: 227 PASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRLEKVPRLICRWTSLHLLY 286
Query: 349 LQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVC-MKGIPYIAAYQKELAHSQPAVQ 407
L + L F L + + N L P ++C +K + + ++ +
Sbjct: 287 LGNTGLHRLRGSFRCLVNLRFLDLSQNHLHHCPLQICALKNLEVLGLDDNKIGQLPSELG 346
Query: 408 PRLKLLLMG 416
KL ++G
Sbjct: 347 SLSKLKILG 355
Score = 97.4 bits (241), Expect = 6e-20
Identities = 73/248 (29%), Positives = 120/248 (48%), Gaps = 2/248 (0%)
Query: 140 LNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQ 199
++ S+ L A+P ++ LEE+ + N++ +P + L +R L +D N L +
Sbjct: 30 IDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRSLCPA 89
Query: 200 LLQLVALEELDVSSNRL-RGLPEDISALRALKILWLSGAELGTLPAG-FCELASLESLML 257
L L +LE LD+S N + +S L AL+ L L +L +P F L LE L L
Sbjct: 90 LGLLSSLESLDLSYNPIFSSSLVVVSFLHALRELRLYQTDLKEIPVVIFKNLHHLELLGL 149
Query: 258 DNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISG 317
N L+ LP + +L+ + L N FE FP L L LE + L N++ ++P I
Sbjct: 150 TGNHLKCLPKEIVNQTKLREIYLKRNQFEVFPQELCVLYTLEIIDLDENKIGAIPEEIGH 209
Query: 318 LGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPL 377
L L ++ +N + LP S+ + + L L L N + +P F +L ++ + N L
Sbjct: 210 LTGLQKFYMASNNLPVLPASLCQCSQLSVLDLSHNLLHSIPKSFAELRKMTEIGLSGNRL 269
Query: 378 IQPPYEVC 385
+ P +C
Sbjct: 270 EKVPRLIC 277
Score = 43.5 bits (101), Expect = 0.001
Identities = 25/81 (30%), Positives = 39/81 (48%)
Query: 274 RLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRY 333
R ++ S+ P + LEE++L NQ+ +P I L + L+LD N +R
Sbjct: 26 RTFFIDASNQSLTAIPLEIFTFTELEEVHLENNQIEEIPQEIQRLKNIRVLYLDKNNLRS 85
Query: 334 LPDSIVELTGLEELVLQGNQI 354
L ++ L+ LE L L N I
Sbjct: 86 LCPALGLLSSLESLDLSYNPI 106
>gi|238908508 leucine-rich repeat and death domain-containing
protein [Homo sapiens]
Length = 860
Score = 155 bits (392), Expect = 2e-37
Identities = 108/358 (30%), Positives = 179/358 (50%), Gaps = 30/358 (8%)
Query: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLT 124
+E L+L +N L E+P+ + L +LR L + RN ++ ++ L +++ L+ S N +T
Sbjct: 397 LECLSLSDNKLTELPKYIHK-LNNLRKLHVNRNNMVKITDCISHL-NNICSLEFSGNIIT 454
Query: 125 ALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLR 184
+ E+ + +++ K+ LS+N++ P L AL L L V+ N ++ +P +S +L
Sbjct: 455 DVPIEIKNC-QKIIKIELSYNKIMYFPLGLCALDSLYYLSVNGNYISEIPVDISFSKQLL 513
Query: 185 TLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPA 244
L++ N+L F L+ L+ LD+ N+++ +P IS + +L +L L + T P
Sbjct: 514 HLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISNMISLHVLILCCNKFETFPR 573
Query: 245 GFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLE----- 299
C L +L+ L L N LQ + + L+ ++ LN SSN F FP L L LE
Sbjct: 574 ELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQFIHFPIELCQLQSLEQLNIS 633
Query: 300 ---------------------ELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSI 338
EL +S N + +P I L L++L NN+I YLP S+
Sbjct: 634 QIKGRKLTRLPGELSNMTQLKELDISNNAIREIPRNIGELRNLVSLHAYNNQISYLPPSL 693
Query: 339 VELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCM-KGIPYIAAY 395
+ L L++L L GN + LP + + DNPL++PP E+C K + IA Y
Sbjct: 694 LSLNDLQQLNLSGNNLTALPSAIYNIFSLKEINFDDNPLLRPPVEICKGKQLYTIARY 751
Score = 145 bits (366), Expect = 2e-34
Identities = 101/333 (30%), Positives = 167/333 (50%), Gaps = 17/333 (5%)
Query: 83 GSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNL 142
G LG L +L L+ N + LP + +L H+L L+VSHN ++ + E+ S L +R+L
Sbjct: 185 GDLLG-LEILSLQENGLSSLPSEI-QLLHNLRILNVSHNHISHIPKEI-SQLGNIRQLFF 241
Query: 143 SHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQ 202
+N + P+ L L +LE L + N+L H+PD+L L LR L++++NQLT FP+ L
Sbjct: 242 YNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTLRVLNLEYNQLTTFPKALCF 301
Query: 203 LVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGL 262
L L LD++ N + LP++I L+ L+ L + +L L +L ++ L L +N L
Sbjct: 302 LPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKL 361
Query: 263 QALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLL 322
+ + + + L++L L NL + P + A LE L LS N+LT +P I L L
Sbjct: 362 EVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLR 421
Query: 323 TLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPY 382
L ++ N + + D I L + L GN I +P ++ ++ N ++ P
Sbjct: 422 KLHVNRNNMVKITDCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPL 481
Query: 383 EVC--------------MKGIPYIAAYQKELAH 401
+C + IP ++ K+L H
Sbjct: 482 GLCALDSLYYLSVNGNYISEIPVDISFSKQLLH 514
Score = 121 bits (303), Expect = 4e-27
Identities = 104/368 (28%), Positives = 156/368 (42%), Gaps = 45/368 (12%)
Query: 62 LGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPA---------------- 105
LG++E L+LG N L +P+ L S L +LRVL L N+ P A
Sbjct: 256 LGNLEILSLGKNKLRHIPDTLPS-LKTLRVLNLEYNQLTTFPKALCFLPKLISLDLTGNL 314
Query: 106 VAELGHHLTELD------VSHNRLTALGAEVVSAL----------------------REL 137
++ L + EL + HN+LT L E+ L REL
Sbjct: 315 ISSLPKEIRELKNLETLLMDHNKLTFLAVEIFQLLKIKELQLADNKLEVISHKIENFREL 374
Query: 138 RKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFP 197
R L L N L +P ++ A LE L +S N+L LP + L+ LR L V+ N +
Sbjct: 375 RILILDKNLLKNIPEKISCCAMLECLSLSDNKLTELPKYIHKLNNLRKLHVNRNNMVKIT 434
Query: 198 RQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLML 257
+ L + L+ S N + +P +I + + + LS ++ P G C L SL L +
Sbjct: 435 DCISHLNNICSLEFSGNIITDVPIEIKNCQKIIKIELSYNKIMYFPLGLCALDSLYYLSV 494
Query: 258 DNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISG 317
+ N + +P S ++L L LS N F L L+ L L +NQ+ +P+ IS
Sbjct: 495 NGNYISEIPVDISFSKQLLHLELSENKLLIFSEHFCSLINLKYLDLGKNQIKKIPASISN 554
Query: 318 LGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPL 377
+ L L L N+ P + L L+ L L NQ+ + L + N
Sbjct: 555 MISLHVLILCCNKFETFPRELCTLENLQVLDLSENQLQKISSDICNLKGIQKLNFSSNQF 614
Query: 378 IQPPYEVC 385
I P E+C
Sbjct: 615 IHFPIELC 622
Score = 102 bits (254), Expect = 2e-21
Identities = 71/249 (28%), Positives = 116/249 (46%), Gaps = 1/249 (0%)
Query: 134 LRELRKLNLSHNQLPALP-AQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQ 192
++ ++ L L NQ+ A G L LE L + N L+ LP + L LR L+V HN
Sbjct: 163 IKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPSEIQLLHNLRILNVSHNH 222
Query: 193 LTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASL 252
++ P+++ QL + +L +N + P D+ L L+IL L +L +P L +L
Sbjct: 223 ISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLGKNKLRHIPDTLPSLKTL 282
Query: 253 ESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVP 312
L L+ N L P L +L L+L+ NL P + L LE L + N+LT +
Sbjct: 283 RVLNLEYNQLTTFPKALCFLPKLISLDLTGNLISSLPKEIRELKNLETLLMDHNKLTFLA 342
Query: 313 SLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKI 372
I L ++ L L +N++ + I L L+L N + +P+ + + +
Sbjct: 343 VEIFQLLKIKELQLADNKLEVISHKIENFRELRILILDKNLLKNIPEKISCCAMLECLSL 402
Query: 373 KDNPLIQPP 381
DN L + P
Sbjct: 403 SDNKLTELP 411
Score = 46.6 bits (109), Expect = 1e-04
Identities = 39/138 (28%), Positives = 64/138 (46%), Gaps = 3/138 (2%)
Query: 278 LNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISG-LGRLLTLWLDNNRIRYLPD 336
+NL + +EFP +L + ++ LYL +NQ+ + SG L L L L N + LP
Sbjct: 146 VNLEAKGLQEFPKDILKIKYVKYLYLDKNQIKTFQGADSGDLLGLEILSLQENGLSSLPS 205
Query: 337 SIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEV-CMKGIPYIAAY 395
I L L L + N I+ +P QL + +N + P ++ C+ + ++
Sbjct: 206 EIQLLHNLRILNVSHNHISHIPKEISQLGNIRQLFFYNNYIENFPSDLECLGNLEILSLG 265
Query: 396 QKELAHSQPAVQPRLKLL 413
+ +L H P P LK L
Sbjct: 266 KNKLRHI-PDTLPSLKTL 282
Score = 46.6 bits (109), Expect = 1e-04
Identities = 28/95 (29%), Positives = 55/95 (57%), Gaps = 3/95 (3%)
Query: 60 ANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVS 119
+N+ ++ L++ NN + E+P +G L +L L N+ + LPP++ L + L +L++S
Sbjct: 648 SNMTQLKELDISNNAIREIPRNIGE-LRNLVSLHAYNNQISYLPPSLLSL-NDLQQLNLS 705
Query: 120 HNRLTALGAEVVSALRELRKLNLSHNQLPALPAQL 154
N LTAL + + + + L+++N N L P ++
Sbjct: 706 GNNLTALPSAIYN-IFSLKEINFDDNPLLRPPVEI 739
>gi|95113664 leucine rich repeat containing 1 [Homo sapiens]
Length = 524
Score = 151 bits (381), Expect = 4e-36
Identities = 102/320 (31%), Positives = 160/320 (50%), Gaps = 2/320 (0%)
Query: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLT 124
+E+++ + L VPE + SL L+L N+ LP +L L +L +S N +
Sbjct: 14 VESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVK-LRKLGLSDNEIQ 72
Query: 125 ALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLR 184
L E+ + + +L +L++S N++P +P + L+ D S N L LP+S L L
Sbjct: 73 RLPPEIANFM-QLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLT 131
Query: 185 TLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPA 244
L V+ L + P + L L L++ N L LP+ ++ LR L+ L L E+ LP
Sbjct: 132 CLSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPE 191
Query: 245 GFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLS 304
L L+ L LD N L LP + L+ L L++S N E P + L L +L +S
Sbjct: 192 SIGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVIS 251
Query: 305 RNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQL 364
+N L ++P I L +L L +D NR+ LP+++ E L ELVL NQ+ LP G+L
Sbjct: 252 QNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKL 311
Query: 365 SRVGLWKIKDNPLIQPPYEV 384
++ N L+ P E+
Sbjct: 312 KKLSNLNADRNKLVSLPKEI 331
Score = 147 bits (370), Expect = 7e-35
Identities = 111/316 (35%), Positives = 157/316 (49%), Gaps = 4/316 (1%)
Query: 60 ANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVS 119
AN + L++ N + E+PE + S +L+V N RLP + EL +LT L V+
Sbjct: 79 ANFMQLVELDVSRNEIPEIPESI-SFCKALQVADFSGNPLTRLPESFPEL-QNLTCLSVN 136
Query: 120 HNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSC 179
L +L E + L L L L N L LP L L LEELD+ N + +LP+S+
Sbjct: 137 DISLQSL-PENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGA 195
Query: 180 LSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAEL 239
L L+ L +D NQL+ P+++ L L LDVS NRL LPE+IS L +L L +S L
Sbjct: 196 LLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLL 255
Query: 240 GTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLE 299
T+P G +L L L +D N L LP + L L L+ N P ++ L L
Sbjct: 256 ETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLS 315
Query: 300 ELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPD 359
L RN+L S+P I G L + +NR+ +P + + T L L + GN++ LP
Sbjct: 316 NLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLPL 375
Query: 360 HFGQLSRVGLWKIKDN 375
L LW + DN
Sbjct: 376 SLTALKLKALW-LSDN 390
Score = 145 bits (365), Expect = 3e-34
Identities = 93/273 (34%), Positives = 137/273 (50%)
Query: 112 HLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLA 171
H+ +D H L + E+ R L +L L NQL LP Q L L +L +S N +
Sbjct: 13 HVESIDKRHCSLVYVPEEIYRYARSLEELLLDANQLRELPEQFFQLVKLRKLGLSDNEIQ 72
Query: 172 HLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKI 231
LP ++ +L LDV N++ P + AL+ D S N L LPE L+ L
Sbjct: 73 RLPPEIANFMQLVELDVSRNEIPEIPESISFCKALQVADFSGNPLTRLPESFPELQNLTC 132
Query: 232 LWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAA 291
L ++ L +LP L +L SL L N L LP + L+RL+ L+L +N P +
Sbjct: 133 LSVNDISLQSLPENIGNLYNLASLELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPES 192
Query: 292 LLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQG 351
+ L L++L+L NQL+ +P I L LL L + NR+ LP+ I LT L +LV+
Sbjct: 193 IGALLHLKDLWLDGNQLSELPQEIGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQ 252
Query: 352 NQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEV 384
N + +PD G+L ++ + K+ N L Q P V
Sbjct: 253 NLLETIPDGIGKLKKLSILKVDQNRLTQLPEAV 285
Score = 136 bits (342), Expect = 1e-31
Identities = 102/339 (30%), Positives = 159/339 (46%), Gaps = 24/339 (7%)
Query: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLT 124
+E L L N L E+PE L LR L L N RLPP +A L ELDVS N +
Sbjct: 38 LEELLLDANQLRELPEQFFQ-LVKLRKLGLSDNEIQRLPPEIANF-MQLVELDVSRNEIP 95
Query: 125 ALGAEV----------------------VSALRELRKLNLSHNQLPALPAQLGALAHLEE 162
+ + L+ L L+++ L +LP +G L +L
Sbjct: 96 EIPESISFCKALQVADFSGNPLTRLPESFPELQNLTCLSVNDISLQSLPENIGNLYNLAS 155
Query: 163 LDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPED 222
L++ N L +LPDSL+ L RL LD+ +N++ P + L+ L++L + N+L LP++
Sbjct: 156 LELRENLLTYLPDSLTQLRRLEELDLGNNEIYNLPESIGALLHLKDLWLDGNQLSELPQE 215
Query: 223 ISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSS 282
I L+ L L +S L LP L SL L++ N L+ +P L++L +L +
Sbjct: 216 IGNLKNLLCLDVSENRLERLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQ 275
Query: 283 NLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELT 342
N + P A+ L EL L+ NQL ++P I L +L L D N++ LP I
Sbjct: 276 NRLTQLPEAVGECESLTELVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCC 335
Query: 343 GLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPP 381
L ++ N++ +P Q + + + + N L+ P
Sbjct: 336 SLTVFCVRDNRLTRIPAEVSQATELHVLDVAGNRLLHLP 374
Score = 92.0 bits (227), Expect = 3e-18
Identities = 70/223 (31%), Positives = 109/223 (48%), Gaps = 25/223 (11%)
Query: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLT 124
+E L+LGNN + +PE +G+ L L+ L L N+ + LP + L + L LDVS NRL
Sbjct: 176 LEELDLGNNEIYNLPESIGALL-HLKDLWLDGNQLSELPQEIGNLKNLLC-LDVSENRLE 233
Query: 125 ALGAEV----------------------VSALRELRKLNLSHNQLPALPAQLGALAHLEE 162
L E+ + L++L L + N+L LP +G L E
Sbjct: 234 RLPEEISGLTSLTDLVISQNLLETIPDGIGKLKKLSILKVDQNRLTQLPEAVGECESLTE 293
Query: 163 LDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPED 222
L ++ N+L LP S+ L +L L+ D N+L + P+++ +L V NRL +P +
Sbjct: 294 LVLTENQLLTLPKSIGKLKKLSNLNADRNKLVSLPKEIGGCCSLTVFCVRDNRLTRIPAE 353
Query: 223 ISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQAL 265
+S L +L ++G L LP L L++L L +N Q L
Sbjct: 354 VSQATELHVLDVAGNRLLHLPLSLTAL-KLKALWLSDNQSQPL 395
>gi|55770895 ERBB2 interacting protein isoform 7 [Homo sapiens]
Length = 1302
Score = 150 bits (380), Expect = 5e-36
Identities = 100/292 (34%), Positives = 146/292 (50%), Gaps = 2/292 (0%)
Query: 92 LVLRRNRFARLPPAVAELGHH--LTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPA 149
+ +R+ F RL P G +T LD SH L + E+ + + L +L L NQ+
Sbjct: 1 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 60
Query: 150 LPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEEL 209
LP QL L +L + N L LP S++ L LR LDV N + FP + L +
Sbjct: 61 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 120
Query: 210 DVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQF 269
+ S N + LP+ S L L L+L+ A L LPA F L L+ L L N L+ LP
Sbjct: 121 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180
Query: 270 SCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNN 329
+ L +L+ L+L SN F E P L L+GL+E ++ N+LT +P I L +L L + N
Sbjct: 181 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240
Query: 330 RIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPP 381
I + + I L++L+L N + LP+ G L + KI +N L+ P
Sbjct: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLP 292
Score = 137 bits (344), Expect = 7e-32
Identities = 106/340 (31%), Positives = 164/340 (48%), Gaps = 24/340 (7%)
Query: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNR-- 122
+E L L N +EE+P+ L + SL L L N LP ++A L +L ELDVS N
Sbjct: 48 LEELYLDANQIEELPKQLFNCQ-SLHKLSLPDNDLTTLPASIANL-INLRELDVSKNGIQ 105
Query: 123 -----------LTALGAEV---------VSALRELRKLNLSHNQLPALPAQLGALAHLEE 162
LT + A V S L L +L L+ L LPA G L L+
Sbjct: 106 EFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQI 165
Query: 163 LDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPED 222
L++ N+L LP +++ L++L LD+ N+ T P L QL L+E + +NRL +P
Sbjct: 166 LELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGF 225
Query: 223 ISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSS 282
I +L+ L L +S + + G +L+ L+L +N LQ LP L+ + L +
Sbjct: 226 IGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDE 285
Query: 283 NLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELT 342
N P ++ L +EEL S N++ ++PS I L L T D+N ++ LP I
Sbjct: 286 NQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWK 345
Query: 343 GLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPY 382
+ L L N++ LP+ G + ++ + + DN L P+
Sbjct: 346 NITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPF 385
Score = 129 bits (324), Expect = 1e-29
Identities = 102/337 (30%), Positives = 162/337 (48%), Gaps = 9/337 (2%)
Query: 48 LESPASPQLVLPA---NLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPP 104
L P + LPA NL ++ L++ NG++E PE + + L ++ N ++LP
Sbjct: 74 LSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCK-VLTIVEASVNPISKLPD 132
Query: 105 AVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELD 164
++L +LT+L ++ L L A L +L+ L L NQL LP + L LE LD
Sbjct: 133 GFSQL-LNLTQLYLNDAFLEFLPANF-GRLTKLQILELRENQLKMLPKTMNRLTQLERLD 190
Query: 165 VSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDIS 224
+ N +P+ L LS L+ +D N+LT P + L L LDVS N + + E IS
Sbjct: 191 LGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGIS 250
Query: 225 ALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNL 284
L+ L LS L LP L ++ +L +D N L LP L ++ L+ S N
Sbjct: 251 TCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNE 310
Query: 285 FEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGL 344
E P+++ L L N L +P I + L+L +N++ LP+ + ++ L
Sbjct: 311 VEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKL 370
Query: 345 EELVLQGNQIAVLPDHFGQLSRVGLWKIKDN---PLI 378
+ + L N++ LP F +L ++ + DN PLI
Sbjct: 371 KVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLI 407
>gi|8923909 ERBB2 interacting protein isoform 2 [Homo sapiens]
Length = 1371
Score = 150 bits (380), Expect = 5e-36
Identities = 100/292 (34%), Positives = 146/292 (50%), Gaps = 2/292 (0%)
Query: 92 LVLRRNRFARLPPAVAELGHH--LTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPA 149
+ +R+ F RL P G +T LD SH L + E+ + + L +L L NQ+
Sbjct: 1 MTTKRSLFVRLVPCRCLRGEEETVTTLDYSHCSLEQVPKEIFTFEKTLEELYLDANQIEE 60
Query: 150 LPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEEL 209
LP QL L +L + N L LP S++ L LR LDV N + FP + L +
Sbjct: 61 LPKQLFNCQSLHKLSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCKVLTIV 120
Query: 210 DVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQF 269
+ S N + LP+ S L L L+L+ A L LPA F L L+ L L N L+ LP
Sbjct: 121 EASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQILELRENQLKMLPKTM 180
Query: 270 SCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNN 329
+ L +L+ L+L SN F E P L L+GL+E ++ N+LT +P I L +L L + N
Sbjct: 181 NRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKN 240
Query: 330 RIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPP 381
I + + I L++L+L N + LP+ G L + KI +N L+ P
Sbjct: 241 NIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLP 292
Score = 137 bits (344), Expect = 7e-32
Identities = 106/340 (31%), Positives = 164/340 (48%), Gaps = 24/340 (7%)
Query: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNR-- 122
+E L L N +EE+P+ L + SL L L N LP ++A L +L ELDVS N
Sbjct: 48 LEELYLDANQIEELPKQLFNCQ-SLHKLSLPDNDLTTLPASIANL-INLRELDVSKNGIQ 105
Query: 123 -----------LTALGAEV---------VSALRELRKLNLSHNQLPALPAQLGALAHLEE 162
LT + A V S L L +L L+ L LPA G L L+
Sbjct: 106 EFPENIKNCKVLTIVEASVNPISKLPDGFSQLLNLTQLYLNDAFLEFLPANFGRLTKLQI 165
Query: 163 LDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPED 222
L++ N+L LP +++ L++L LD+ N+ T P L QL L+E + +NRL +P
Sbjct: 166 LELRENQLKMLPKTMNRLTQLERLDLGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGF 225
Query: 223 ISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSS 282
I +L+ L L +S + + G +L+ L+L +N LQ LP L+ + L +
Sbjct: 226 IGSLKQLTYLDVSKNNIEMVEEGISTCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDE 285
Query: 283 NLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELT 342
N P ++ L +EEL S N++ ++PS I L L T D+N ++ LP I
Sbjct: 286 NQLMYLPDSIGGLISVEELDCSFNEVEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWK 345
Query: 343 GLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPY 382
+ L L N++ LP+ G + ++ + + DN L P+
Sbjct: 346 NITVLFLHSNKLETLPEEMGDMQKLKVINLSDNRLKNLPF 385
Score = 129 bits (324), Expect = 1e-29
Identities = 102/337 (30%), Positives = 162/337 (48%), Gaps = 9/337 (2%)
Query: 48 LESPASPQLVLPA---NLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPP 104
L P + LPA NL ++ L++ NG++E PE + + L ++ N ++LP
Sbjct: 74 LSLPDNDLTTLPASIANLINLRELDVSKNGIQEFPENIKNCK-VLTIVEASVNPISKLPD 132
Query: 105 AVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELD 164
++L +LT+L ++ L L A L +L+ L L NQL LP + L LE LD
Sbjct: 133 GFSQL-LNLTQLYLNDAFLEFLPANF-GRLTKLQILELRENQLKMLPKTMNRLTQLERLD 190
Query: 165 VSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDIS 224
+ N +P+ L LS L+ +D N+LT P + L L LDVS N + + E IS
Sbjct: 191 LGSNEFTEVPEVLEQLSGLKEFWMDANRLTFIPGFIGSLKQLTYLDVSKNNIEMVEEGIS 250
Query: 225 ALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNL 284
L+ L LS L LP L ++ +L +D N L LP L ++ L+ S N
Sbjct: 251 TCENLQDLLLSSNSLQQLPETIGSLKNITTLKIDENQLMYLPDSIGGLISVEELDCSFNE 310
Query: 285 FEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGL 344
E P+++ L L N L +P I + L+L +N++ LP+ + ++ L
Sbjct: 311 VEALPSSIGQLTNLRTFAADHNYLQQLPPEIGSWKNITVLFLHSNKLETLPEEMGDMQKL 370
Query: 345 EELVLQGNQIAVLPDHFGQLSRVGLWKIKDN---PLI 378
+ + L N++ LP F +L ++ + DN PLI
Sbjct: 371 KVINLSDNRLKNLPFSFTKLQQLTAMWLSDNQSKPLI 407
>gi|45827729 scribble isoform b [Homo sapiens]
Length = 1630
Score = 147 bits (371), Expect = 5e-35
Identities = 96/268 (35%), Positives = 138/268 (51%)
Query: 112 HLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLA 171
H+ +D H L A+ E+ R L +L L NQL LP L +L +L +S N +
Sbjct: 13 HVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQ 72
Query: 172 HLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKI 231
LP ++ +L LDV N + P + ALE D S N L LP+ + LR+L
Sbjct: 73 RLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAH 132
Query: 232 LWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAA 291
L L+ L LP LA+L +L L N L++LPA S L +L+ L+L N E P
Sbjct: 133 LALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDT 192
Query: 292 LLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQG 351
L L L EL+L RNQL+++P + L RL+ L + NR+ LP + L L +L+L
Sbjct: 193 LGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQ 252
Query: 352 NQIAVLPDHFGQLSRVGLWKIKDNPLIQ 379
N + LPD GQL ++ + K+ N L +
Sbjct: 253 NLLRRLPDGIGQLKQLSILKVDQNRLCE 280
Score = 144 bits (363), Expect = 4e-34
Identities = 113/313 (36%), Positives = 150/313 (47%), Gaps = 7/313 (2%)
Query: 60 ANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGH--HLTELD 117
AN + L++ N + E+PE + +L + N +RLP +L HL D
Sbjct: 79 ANFMQLVELDVSRNDIPEIPESI-KFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALND 137
Query: 118 VSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSL 177
VS L AL +V + L L L L N L +LPA L L LE+LD+ N L LPD+L
Sbjct: 138 VS---LQALPGDVGN-LANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTL 193
Query: 178 SCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGA 237
L LR L +D NQL+A P +L L L LDVS NRL LP ++ L L L LS
Sbjct: 194 GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
Query: 238 ELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAG 297
L LP G +L L L +D N L + + L L L+ NL P +L L
Sbjct: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
Query: 298 LEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVL 357
L L + RN L ++P I G L L L +NR+ LP + T L L + GN++ L
Sbjct: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSL 373
Query: 358 PDHFGQLSRVGLW 370
P L+ LW
Sbjct: 374 PFALTHLNLKALW 386
Score = 144 bits (362), Expect = 6e-34
Identities = 107/320 (33%), Positives = 163/320 (50%), Gaps = 2/320 (0%)
Query: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLT 124
+E+++ + L+ VPE + SL L+L N+ LP L +L +L +S N +
Sbjct: 14 VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRL-LNLRKLGLSDNEIQ 72
Query: 125 ALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLR 184
L EV + + +L +L++S N +P +P + LE D S N L+ LPD + L L
Sbjct: 73 RLPPEVANFM-QLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLA 131
Query: 185 TLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPA 244
L ++ L A P + L L L++ N L+ LP +S L L+ L L G +L LP
Sbjct: 132 HLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPD 191
Query: 245 GFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLS 304
L +L L LD N L ALP + L+RL L++S N EE PA L L L +L LS
Sbjct: 192 TLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLS 251
Query: 305 RNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQL 364
+N L +P I L +L L +D NR+ + ++I + L EL+L N + LP G+L
Sbjct: 252 QNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKL 311
Query: 365 SRVGLWKIKDNPLIQPPYEV 384
+++ + N L P E+
Sbjct: 312 TKLTNLNVDRNHLEALPPEI 331
Score = 137 bits (344), Expect = 7e-32
Identities = 124/414 (29%), Positives = 179/414 (43%), Gaps = 35/414 (8%)
Query: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLT 124
+E L L N L E+P+ L +LR L L N RLPP VA L ELDVS N +
Sbjct: 38 LEELLLDANQLRELPKPFFRLL-NLRKLGLSDNEIQRLPPEVANF-MQLVELDVSRNDIP 95
Query: 125 ALGAEV----------------------VSALRELRKLNLSHNQLPALPAQLGALAHLEE 162
+ + + LR L L L+ L ALP +G LA+L
Sbjct: 96 EIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVT 155
Query: 163 LDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPED 222
L++ N L LP SLS L +L LD+ N L P L L L EL + N+L LP +
Sbjct: 156 LELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPE 215
Query: 223 ISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSS 282
+ LR L L +S L LPA L L L+L N L+ LP L++L +L +
Sbjct: 216 LGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQ 275
Query: 283 NLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELT 342
N E A+ L EL L+ N L ++P + L +L L +D N + LP I
Sbjct: 276 NRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCV 335
Query: 343 GLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHS 402
L L L+ N++AVLP + + + + N L P+ + + K L +
Sbjct: 336 ALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNL-------KALWLA 388
Query: 403 QPAVQPRLKLLLMGHKAAGKTLLRHCLTEER----VEGCPGGGDKEKCYPPSPP 452
+ QP L+ G+ +L L ++ +E G + + +PP
Sbjct: 389 ENQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPLSLEDAGQQGSLSETWSDAPP 442
>gi|45827731 scribble isoform a [Homo sapiens]
Length = 1655
Score = 147 bits (371), Expect = 5e-35
Identities = 96/268 (35%), Positives = 138/268 (51%)
Query: 112 HLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLA 171
H+ +D H L A+ E+ R L +L L NQL LP L +L +L +S N +
Sbjct: 13 HVESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRLLNLRKLGLSDNEIQ 72
Query: 172 HLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKI 231
LP ++ +L LDV N + P + ALE D S N L LP+ + LR+L
Sbjct: 73 RLPPEVANFMQLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAH 132
Query: 232 LWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAA 291
L L+ L LP LA+L +L L N L++LPA S L +L+ L+L N E P
Sbjct: 133 LALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDT 192
Query: 292 LLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQG 351
L L L EL+L RNQL+++P + L RL+ L + NR+ LP + L L +L+L
Sbjct: 193 LGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQ 252
Query: 352 NQIAVLPDHFGQLSRVGLWKIKDNPLIQ 379
N + LPD GQL ++ + K+ N L +
Sbjct: 253 NLLRRLPDGIGQLKQLSILKVDQNRLCE 280
Score = 144 bits (363), Expect = 4e-34
Identities = 113/313 (36%), Positives = 150/313 (47%), Gaps = 7/313 (2%)
Query: 60 ANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGH--HLTELD 117
AN + L++ N + E+PE + +L + N +RLP +L HL D
Sbjct: 79 ANFMQLVELDVSRNDIPEIPESI-KFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALND 137
Query: 118 VSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSL 177
VS L AL +V + L L L L N L +LPA L L LE+LD+ N L LPD+L
Sbjct: 138 VS---LQALPGDVGN-LANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTL 193
Query: 178 SCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGA 237
L LR L +D NQL+A P +L L L LDVS NRL LP ++ L L L LS
Sbjct: 194 GALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQN 253
Query: 238 ELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAG 297
L LP G +L L L +D N L + + L L L+ NL P +L L
Sbjct: 254 LLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTK 313
Query: 298 LEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVL 357
L L + RN L ++P I G L L L +NR+ LP + T L L + GN++ L
Sbjct: 314 LTNLNVDRNHLEALPPEIGGCVALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSL 373
Query: 358 PDHFGQLSRVGLW 370
P L+ LW
Sbjct: 374 PFALTHLNLKALW 386
Score = 144 bits (362), Expect = 6e-34
Identities = 107/320 (33%), Positives = 163/320 (50%), Gaps = 2/320 (0%)
Query: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLT 124
+E+++ + L+ VPE + SL L+L N+ LP L +L +L +S N +
Sbjct: 14 VESVDKRHCSLQAVPEEIYRYSRSLEELLLDANQLRELPKPFFRL-LNLRKLGLSDNEIQ 72
Query: 125 ALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLR 184
L EV + + +L +L++S N +P +P + LE D S N L+ LPD + L L
Sbjct: 73 RLPPEVANFM-QLVELDVSRNDIPEIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLA 131
Query: 185 TLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPA 244
L ++ L A P + L L L++ N L+ LP +S L L+ L L G +L LP
Sbjct: 132 HLALNDVSLQALPGDVGNLANLVTLELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPD 191
Query: 245 GFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLS 304
L +L L LD N L ALP + L+RL L++S N EE PA L L L +L LS
Sbjct: 192 TLGALPNLRELWLDRNQLSALPPELGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLS 251
Query: 305 RNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQL 364
+N L +P I L +L L +D NR+ + ++I + L EL+L N + LP G+L
Sbjct: 252 QNLLRRLPDGIGQLKQLSILKVDQNRLCEVTEAIGDCENLSELILTENLLMALPRSLGKL 311
Query: 365 SRVGLWKIKDNPLIQPPYEV 384
+++ + N L P E+
Sbjct: 312 TKLTNLNVDRNHLEALPPEI 331
Score = 137 bits (344), Expect = 7e-32
Identities = 124/414 (29%), Positives = 179/414 (43%), Gaps = 35/414 (8%)
Query: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLT 124
+E L L N L E+P+ L +LR L L N RLPP VA L ELDVS N +
Sbjct: 38 LEELLLDANQLRELPKPFFRLL-NLRKLGLSDNEIQRLPPEVANF-MQLVELDVSRNDIP 95
Query: 125 ALGAEV----------------------VSALRELRKLNLSHNQLPALPAQLGALAHLEE 162
+ + + LR L L L+ L ALP +G LA+L
Sbjct: 96 EIPESIKFCKALEIADFSGNPLSRLPDGFTQLRSLAHLALNDVSLQALPGDVGNLANLVT 155
Query: 163 LDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPED 222
L++ N L LP SLS L +L LD+ N L P L L L EL + N+L LP +
Sbjct: 156 LELRENLLKSLPASLSFLVKLEQLDLGGNDLEVLPDTLGALPNLRELWLDRNQLSALPPE 215
Query: 223 ISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSS 282
+ LR L L +S L LPA L L L+L N L+ LP L++L +L +
Sbjct: 216 LGNLRRLVCLDVSENRLEELPAELGGLVLLTDLLLSQNLLRRLPDGIGQLKQLSILKVDQ 275
Query: 283 NLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELT 342
N E A+ L EL L+ N L ++P + L +L L +D N + LP I
Sbjct: 276 NRLCEVTEAIGDCENLSELILTENLLMALPRSLGKLTKLTNLNVDRNHLEALPPEIGGCV 335
Query: 343 GLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHS 402
L L L+ N++AVLP + + + + N L P+ + + K L +
Sbjct: 336 ALSVLSLRDNRLAVLPPELAHTTELHVLDVAGNRLQSLPFALTHLNL-------KALWLA 388
Query: 403 QPAVQPRLKLLLMGHKAAGKTLLRHCLTEER----VEGCPGGGDKEKCYPPSPP 452
+ QP L+ G+ +L L ++ +E G + + +PP
Sbjct: 389 ENQAQPMLRFQTEDDARTGEKVLTCYLLPQQPPLSLEDAGQQGSLSETWSDAPP 442
>gi|41281398 soc-2 suppressor of clear homolog [Homo sapiens]
Length = 582
Score = 143 bits (361), Expect = 7e-34
Identities = 107/364 (29%), Positives = 175/364 (48%), Gaps = 30/364 (8%)
Query: 61 NLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSH 120
NL + L++ N ++++P +G L +L L + N+ LP + +T LD+ H
Sbjct: 213 NLSKLSMLSIRENKIKQLPAEIGE-LCNLITLDVAHNQLEHLPKEIGNCTQ-ITNLDLQH 270
Query: 121 NRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSL--- 177
N L L + + L L +L L +N+L A+P L + LEEL++ N ++ LP+SL
Sbjct: 271 NELLDL-PDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSS 329
Query: 178 ----------------------SCLSRLRTLDVDHNQLTAFPRQLLQLV-ALEELDVSSN 214
S S + +L+++HN++ P + L +L++ N
Sbjct: 330 LVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDN 389
Query: 215 RLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQR 274
+L LP D ++ L L+ +L +P L SLE L+L NN L+ LP L++
Sbjct: 390 QLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSGLVSLEVLILSNNLLKKLPHGLGNLRK 449
Query: 275 LKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYL 334
L+ L+L N E P + L L++L L+ NQLT++P I L L L L N + +L
Sbjct: 450 LRELDLEENKLESLPNEIAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHL 509
Query: 335 PDSIVELTGLEELVLQGN-QIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIA 393
P+ I L LEEL L N + LP S++ + I++ PL P ++ G +I
Sbjct: 510 PEEIGTLENLEELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIVAGGPSFII 569
Query: 394 AYQK 397
+ K
Sbjct: 570 QFLK 573
Score = 129 bits (323), Expect = 2e-29
Identities = 90/281 (32%), Positives = 131/281 (46%), Gaps = 24/281 (8%)
Query: 60 ANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVS 119
A +E LNL NN + +PE L S+L L L L RN F P + L++
Sbjct: 304 AKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCFQLYPVGGPSQFSTIYSLNME 363
Query: 120 HNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSC 179
HNR+ + + S + L KLN+ NQL +LP G + EL+++ N+L +P+ +S
Sbjct: 364 HNRINKIPFGIFSRAKVLSKLNMKDNQLTSLPLDFGTWTSMVELNLATNQLTKIPEDVSG 423
Query: 180 LSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAEL 239
L L L + +N L P L L L ELD+ N+L LP +I+ L+
Sbjct: 424 LVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNEIAYLK------------ 471
Query: 240 GTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLE 299
L+ L+L NN L LP L L L L NL P + L LE
Sbjct: 472 -----------DLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLE 520
Query: 300 ELYLSRN-QLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIV 339
ELYL+ N L S+P ++ +L + ++N + +LP IV
Sbjct: 521 ELYLNDNPNLHSLPFELALCSKLSIMSIENCPLSHLPPQIV 561
Score = 118 bits (295), Expect = 3e-26
Identities = 78/243 (32%), Positives = 119/243 (48%), Gaps = 5/243 (2%)
Query: 122 RLTALGAEVVSALRELR-----KLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDS 176
R + AEV+ L + R +L+LS + LP+ + L L EL + N+L LP
Sbjct: 82 RKKSSNAEVIKELNKCREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAE 141
Query: 177 LSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSG 236
+ CL L TL + N LT+ P L L L LD+ N+LR +P + L +L L+L
Sbjct: 142 VGCLVNLMTLALSENSLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRF 201
Query: 237 AELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLA 296
+ T+ L+ L L + N ++ LPA+ L L L+++ N E P +
Sbjct: 202 NRITTVEKDIKNLSKLSMLSIRENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCT 261
Query: 297 GLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAV 356
+ L L N+L +P I L L L L NR+ +P S+ + + LEEL L+ N I+
Sbjct: 262 QITNLDLQHNELLDLPDTIGNLSSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNIST 321
Query: 357 LPD 359
LP+
Sbjct: 322 LPE 324
Score = 116 bits (290), Expect = 1e-25
Identities = 81/244 (33%), Positives = 130/244 (53%), Gaps = 2/244 (0%)
Query: 116 LDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPD 175
LD+S + L + + L +L +L L N+L +LPA++G L +L L +S N L LPD
Sbjct: 105 LDLSKRSIHILPSSI-KELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPD 163
Query: 176 SLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLS 235
SL L +LR LD+ HN+L P + +L +L L + NR+ + +DI L L +L +
Sbjct: 164 SLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIR 223
Query: 236 GAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPL 295
++ LPA EL +L +L + +N L+ LP + ++ L+L N + P + L
Sbjct: 224 ENKIKQLPAEIGELCNLITLDVAHNQLEHLPKEIGNCTQITNLDLQHNELLDLPDTIGNL 283
Query: 296 AGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIV-ELTGLEELVLQGNQI 354
+ L L L N+L+++P ++ L L L+NN I LP+S++ L L L L N
Sbjct: 284 SSLSRLGLRYNRLSAIPRSLAKCSALEELNLENNNISTLPESLLSSLVKLNSLTLARNCF 343
Query: 355 AVLP 358
+ P
Sbjct: 344 QLYP 347
Score = 98.6 bits (244), Expect = 3e-20
Identities = 73/213 (34%), Positives = 111/213 (52%), Gaps = 7/213 (3%)
Query: 59 PANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELG--HHLTEL 116
P+ I +LN+ +N + ++P G+ S L L ++ N+ LP + G + EL
Sbjct: 351 PSQFSTIYSLNMEHNRINKIPFGIFSRAKVLSKLNMKDNQLTSLP---LDFGTWTSMVEL 407
Query: 117 DVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDS 176
+++ N+LT + E VS L L L LS+N L LP LG L L ELD+ N+L LP+
Sbjct: 408 NLATNQLTKI-PEDVSGLVSLEVLILSNNLLKKLPHGLGNLRKLRELDLEENKLESLPNE 466
Query: 177 LSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLS- 235
++ L L+ L + +NQLT PR + L L L + N L LPE+I L L+ L+L+
Sbjct: 467 IAYLKDLQKLVLTNNQLTTLPRGIGHLTNLTHLGLGENLLTHLPEEIGTLENLEELYLND 526
Query: 236 GAELGTLPAGFCELASLESLMLDNNGLQALPAQ 268
L +LP + L + ++N L LP Q
Sbjct: 527 NPNLHSLPFELALCSKLSIMSIENCPLSHLPPQ 559
Score = 79.7 bits (195), Expect = 1e-14
Identities = 54/151 (35%), Positives = 74/151 (49%)
Query: 234 LSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALL 293
LS + LP+ EL L L L +N LQ+LPA+ CL L L LS N P +L
Sbjct: 107 LSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSENSLTSLPDSLD 166
Query: 294 PLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQ 353
L L L L N+L +PS++ L L TL+L NRI + I L+ L L ++ N+
Sbjct: 167 NLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSKLSMLSIRENK 226
Query: 354 IAVLPDHFGQLSRVGLWKIKDNPLIQPPYEV 384
I LP G+L + + N L P E+
Sbjct: 227 IKQLPAEIGELCNLITLDVAHNQLEHLPKEI 257
Score = 68.2 bits (165), Expect = 4e-11
Identities = 43/138 (31%), Positives = 67/138 (48%)
Query: 247 CELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRN 306
C + L L + LP+ L +L L L SN + PA + L L L LS N
Sbjct: 97 CREENSMRLDLSKRSIHILPSSIKELTQLTELYLYSNKLQSLPAEVGCLVNLMTLALSEN 156
Query: 307 QLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSR 366
LTS+P + L +L L L +N++R +P + L L L L+ N+I + LS+
Sbjct: 157 SLTSLPDSLDNLKKLRMLDLRHNKLREIPSVVYRLDSLTTLYLRFNRITTVEKDIKNLSK 216
Query: 367 VGLWKIKDNPLIQPPYEV 384
+ + I++N + Q P E+
Sbjct: 217 LSMLSIRENKIKQLPAEI 234
>gi|225579152 insulin-like growth factor binding protein, acid
labile subunit isoform 1 precursor [Homo sapiens]
Length = 643
Score = 140 bits (354), Expect = 5e-33
Identities = 130/364 (35%), Positives = 176/364 (48%), Gaps = 12/364 (3%)
Query: 26 RSNLRQLTLTAAGACPGAGADALESPASPQLV--LPANLGDIEALNLGNNGLEEVPEGLG 83
R+ LR L L P + L + +L L LG + LNLG N L +P+
Sbjct: 169 RNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAF 228
Query: 84 SALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLS 143
LGSLR LVL NR A L PA+ L ELD+S N L A+ A V L L+KL L
Sbjct: 229 RGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLD 288
Query: 144 HNQLPAL-PAQLGALAHLEELDVSFNRLAH-LPDSLSCLSRLRTLDVDHNQLTAF-PRQL 200
N + A+ P L L LD+S NR+A L D+ L LR L + HN + + PR
Sbjct: 289 RNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTF 348
Query: 201 LQLVALEELDVSSNRLRGLPE-DISALRALKILWLSGAELGTLPAG-FCELASLESLMLD 258
L LEEL + NR+R L E L L++L L +L + AG F L ++ + L
Sbjct: 349 KDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLS 408
Query: 259 NNGLQALPAQ-FSCLQRLKMLNLSSNLFEEF-PAALLPLAGLEELYLSRNQLTSV-PSLI 315
N L+ LP Q F L +L L+L + P L+GL L+L N L + +
Sbjct: 409 GNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSL 468
Query: 316 SGLGRLLTLWLDNNRIRYLPDSIVELTG-LEELVLQGNQIAVLP-DHFGQLSRVGLWKIK 373
GL LL L L +N++ +LP + + G LE L+L N++A LP D G L R +
Sbjct: 469 WGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVS 528
Query: 374 DNPL 377
N L
Sbjct: 529 HNRL 532
Score = 95.9 bits (237), Expect = 2e-19
Identities = 106/347 (30%), Positives = 149/347 (42%), Gaps = 57/347 (16%)
Query: 63 GDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNR 122
G +AL L N L VP L SL L L+ + L P +L L + N+
Sbjct: 112 GGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQ 171
Query: 123 LTALGAEVVSALRELRKLNLSHNQLPAL-------------------------PAQLGAL 157
L +L + L L LS+N+L L A L
Sbjct: 172 LRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGL 231
Query: 158 AHLEELDVSFNRLAHL-PDSLSCLSRLRTLDVDHNQLTAF-------------------- 196
L EL ++ NRLA+L P S L+ LR LD+ N L A
Sbjct: 232 GSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNL 291
Query: 197 -----PRQLLQLVALEELDVSSNRLRGLPED-ISALRALKILWLSGAELGTL-PAGFCEL 249
P L L AL LD+S NR+ GL ED L L++L LS + +L P F +L
Sbjct: 292 IAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDL 351
Query: 250 ASLESLMLDNNGLQALPAQ-FSCLQRLKMLNLSSNLFEEFPA-ALLPLAGLEELYLSRNQ 307
LE L L +N ++ L + F L +L++L L N +E A A L L + + LS N
Sbjct: 352 HFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC 411
Query: 308 LTSVP-SLISGLGRLLTLWLDNNRI-RYLPDSIVELTGLEELVLQGN 352
L ++P + GLG+L +L L+ + + R P + L+GL L L+ N
Sbjct: 412 LRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDN 458
Score = 77.4 bits (189), Expect = 7e-14
Identities = 71/201 (35%), Positives = 92/201 (45%), Gaps = 10/201 (4%)
Query: 62 LGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHN 121
L ++ +NL N L +PE + LG L L L + R+ P L L + N
Sbjct: 399 LTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDN 458
Query: 122 RLTALGAEVVSALRELRKLNLSHNQLPALPAQL-GALAHLEELDVSFNRLAHLP-DSLSC 179
L + + + L EL +L+L+ NQL LP +L L LE L +S NRLA LP D+L
Sbjct: 459 GLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGP 518
Query: 180 LSRLRTLDVDHNQLTAFPRQLL-QLVALEELDVSSNRLRGLPEDISALRALKILWLSGAE 238
L R LDV HN+L A P LL L L L + +N LR L LWL G
Sbjct: 519 LQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLER---LWLEG-- 573
Query: 239 LGTLPAGFCELASLESLMLDN 259
G C L +L L N
Sbjct: 574 -NPWDCG-CPLKALRDFALQN 592
>gi|4826772 insulin-like growth factor binding protein, acid labile
subunit isoform 2 precursor [Homo sapiens]
Length = 605
Score = 140 bits (354), Expect = 5e-33
Identities = 130/364 (35%), Positives = 176/364 (48%), Gaps = 12/364 (3%)
Query: 26 RSNLRQLTLTAAGACPGAGADALESPASPQLV--LPANLGDIEALNLGNNGLEEVPEGLG 83
R+ LR L L P + L + +L L LG + LNLG N L +P+
Sbjct: 131 RNQLRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAF 190
Query: 84 SALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLS 143
LGSLR LVL NR A L PA+ L ELD+S N L A+ A V L L+KL L
Sbjct: 191 RGLGSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLD 250
Query: 144 HNQLPAL-PAQLGALAHLEELDVSFNRLAH-LPDSLSCLSRLRTLDVDHNQLTAF-PRQL 200
N + A+ P L L LD+S NR+A L D+ L LR L + HN + + PR
Sbjct: 251 RNLIAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTF 310
Query: 201 LQLVALEELDVSSNRLRGLPE-DISALRALKILWLSGAELGTLPAG-FCELASLESLMLD 258
L LEEL + NR+R L E L L++L L +L + AG F L ++ + L
Sbjct: 311 KDLHFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLS 370
Query: 259 NNGLQALPAQ-FSCLQRLKMLNLSSNLFEEF-PAALLPLAGLEELYLSRNQLTSV-PSLI 315
N L+ LP Q F L +L L+L + P L+GL L+L N L + +
Sbjct: 371 GNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDNGLVGIEEQSL 430
Query: 316 SGLGRLLTLWLDNNRIRYLPDSIVELTG-LEELVLQGNQIAVLP-DHFGQLSRVGLWKIK 373
GL LL L L +N++ +LP + + G LE L+L N++A LP D G L R +
Sbjct: 431 WGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGPLQRAFWLDVS 490
Query: 374 DNPL 377
N L
Sbjct: 491 HNRL 494
Score = 95.9 bits (237), Expect = 2e-19
Identities = 106/347 (30%), Positives = 149/347 (42%), Gaps = 57/347 (16%)
Query: 63 GDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNR 122
G +AL L N L VP L SL L L+ + L P +L L + N+
Sbjct: 74 GGTQALWLDGNNLSSVPPAAFQNLSSLGFLNLQGGQLGSLEPQALLGLENLCHLHLERNQ 133
Query: 123 LTALGAEVVSALRELRKLNLSHNQLPAL-------------------------PAQLGAL 157
L +L + L L LS+N+L L A L
Sbjct: 134 LRSLALGTFAHTPALASLGLSNNRLSRLEDGLFEGLGSLWDLNLGWNSLAVLPDAAFRGL 193
Query: 158 AHLEELDVSFNRLAHL-PDSLSCLSRLRTLDVDHNQLTAF-------------------- 196
L EL ++ NRLA+L P S L+ LR LD+ N L A
Sbjct: 194 GSLRELVLAGNRLAYLQPALFSGLAELRELDLSRNALRAIKANVFVQLPRLQKLYLDRNL 253
Query: 197 -----PRQLLQLVALEELDVSSNRLRGLPED-ISALRALKILWLSGAELGTL-PAGFCEL 249
P L L AL LD+S NR+ GL ED L L++L LS + +L P F +L
Sbjct: 254 IAAVAPGAFLGLKALRWLDLSHNRVAGLLEDTFPGLLGLRVLRLSHNAIASLRPRTFKDL 313
Query: 250 ASLESLMLDNNGLQALPAQ-FSCLQRLKMLNLSSNLFEEFPA-ALLPLAGLEELYLSRNQ 307
LE L L +N ++ L + F L +L++L L N +E A A L L + + LS N
Sbjct: 314 HFLEELQLGHNRIRQLAERSFEGLGQLEVLTLDHNQLQEVKAGAFLGLTNVAVMNLSGNC 373
Query: 308 LTSVP-SLISGLGRLLTLWLDNNRI-RYLPDSIVELTGLEELVLQGN 352
L ++P + GLG+L +L L+ + + R P + L+GL L L+ N
Sbjct: 374 LRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDN 420
Score = 77.4 bits (189), Expect = 7e-14
Identities = 71/201 (35%), Positives = 92/201 (45%), Gaps = 10/201 (4%)
Query: 62 LGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHN 121
L ++ +NL N L +PE + LG L L L + R+ P L L + N
Sbjct: 361 LTNVAVMNLSGNCLRNLPEQVFRGLGKLHSLHLEGSCLGRIRPHTFTGLSGLRRLFLKDN 420
Query: 122 RLTALGAEVVSALRELRKLNLSHNQLPALPAQL-GALAHLEELDVSFNRLAHLP-DSLSC 179
L + + + L EL +L+L+ NQL LP +L L LE L +S NRLA LP D+L
Sbjct: 421 GLVGIEEQSLWGLAELLELDLTSNQLTHLPHRLFQGLGKLEYLLLSRNRLAELPADALGP 480
Query: 180 LSRLRTLDVDHNQLTAFPRQLL-QLVALEELDVSSNRLRGLPEDISALRALKILWLSGAE 238
L R LDV HN+L A P LL L L L + +N LR L LWL G
Sbjct: 481 LQRAFWLDVSHNRLEALPNSLLAPLGRLRYLSLRNNSLRTFTPQPPGLER---LWLEG-- 535
Query: 239 LGTLPAGFCELASLESLMLDN 259
G C L +L L N
Sbjct: 536 -NPWDCG-CPLKALRDFALQN 554
>gi|21361633 leucine rich repeat containing 40 [Homo sapiens]
Length = 602
Score = 139 bits (349), Expect = 2e-32
Identities = 87/228 (38%), Positives = 134/228 (58%), Gaps = 2/228 (0%)
Query: 160 LEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGL 219
L +L +S N+L L D L L L LD+ NQLT+ P + +L L++L+VS N+L+ L
Sbjct: 84 LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKIL 143
Query: 220 PEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLN 279
PE+I+ LR LK L+L EL + GF +L++LE L L NN L +PA FS L L LN
Sbjct: 144 PEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLN 203
Query: 280 LSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIV 339
LSSN + PA + + L+ L + N L ++P ++G+ L L+L N++R+LP+
Sbjct: 204 LSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPE-FP 262
Query: 340 ELTGLEELVLQGNQIAVL-PDHFGQLSRVGLWKIKDNPLIQPPYEVCM 386
+ L+EL + NQI +L +H L+ + + ++DN L P E+ +
Sbjct: 263 SCSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIIL 310
Score = 137 bits (346), Expect = 4e-32
Identities = 109/342 (31%), Positives = 162/342 (47%), Gaps = 28/342 (8%)
Query: 78 VPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGA-EVVSALRE 136
VP+GL A L L + +P V + + E N+ + GA E +
Sbjct: 27 VPQGLLKAARKSGQLNLSGRNLSEVPQCVWRINVDIPE---EANQNLSFGATERWWEQTD 83
Query: 137 LRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAF 196
L KL +S+N+L +L L L L LD+ N+L LP ++ L L+ L+V HN+L
Sbjct: 84 LTKLIISNNKLQSLTDDLRLLPALTVLDIHDNQLTSLPSAIRELENLQKLNVSHNKLKIL 143
Query: 197 PRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLM 256
P ++ L L+ L + N L + E L L+ L LS L T+PA F L+SL L
Sbjct: 144 PEEITNLRNLKCLYLQHNELTCISEGFEQLSNLEDLDLSNNHLTTVPASFSSLSSLVRLN 203
Query: 257 LDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSL-- 314
L +N L++LPA+ + ++RLK L+ +SNL E P L + LE LYL RN+L +P
Sbjct: 204 LSSNELKSLPAEINRMKRLKHLDCNSNLLETIPPELAGMESLELLYLRRNKLRFLPEFPS 263
Query: 315 ---------------------ISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQ 353
+ L +L L L +N+++ +PD I+ L LE L L N
Sbjct: 264 CSLLKELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNND 323
Query: 354 IAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAY 395
I+ LP G L + ++ NPL E+ KG + Y
Sbjct: 324 ISSLPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKY 364
Score = 97.4 bits (241), Expect = 6e-20
Identities = 98/393 (24%), Positives = 173/393 (44%), Gaps = 58/393 (14%)
Query: 58 LPANLGDIEAL---NLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLP--PAVAELGHH 112
LPA + ++ L + +N LE +P L + + SL +L LRRN+ LP P+ + L
Sbjct: 212 LPAEINRMKRLKHLDCNSNLLETIPPEL-AGMESLELLYLRRNKLRFLPEFPSCSLL--- 267
Query: 113 LTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAH 172
EL V N++ L AE + L + L+L N+L ++P ++ L LE LD+S N ++
Sbjct: 268 -KELHVGENQIEMLEAEHLKHLNSILVLDLRDNKLKSVPDEIILLRSLERLDLSNNDISS 326
Query: 173 LPDSLSCLSRLRTLDVDHNQLTAFPRQLLQ------------------------------ 202
LP SL L L+ L ++ N L R+++
Sbjct: 327 LPYSLGNL-HLKFLALEGNPLRTIRREIISKGTQEVLKYLRSKIKDDGPSQSESATETAM 385
Query: 203 ------------LVALEELDVSSNRLRGLPEDI-SALRA--LKILWLSGAELGTLPAGFC 247
++ L+ LD S + +P+++ A+++ + + S +L +P
Sbjct: 386 TLPSESRVNIHAIITLKILDYSDKQATLIPDEVFDAVKSNIVTSINFSKNQLCEIPKRMV 445
Query: 248 ELASLES-LMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRN 306
EL + S + L N L + + LQ+L L+L +N P + L L+ + LS N
Sbjct: 446 ELKEMVSDVDLSFNKLSFISLELCVLQKLTFLDLRNNFLNSLPEEMESLVRLQTINLSFN 505
Query: 307 QLTSVPSLISGLGRLLTLWLDNNRIRYL-PDSIVELTGLEELVLQGNQIAVLPDHFGQLS 365
+ +P ++ + L T+ + NN++ + P + + L L LQ N + +P G
Sbjct: 506 RFKMLPEVLYRIFTLETILISNNQVGSVDPQKMKMMENLTTLDLQNNDLLQIPPELGNCV 565
Query: 366 RVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKE 398
+ + NP P + MKG I Y ++
Sbjct: 566 NLRTLLLDGNPFRVPRAAILMKGTAAILEYLRD 598
>gi|16904383 leucine rich repeat containing 7 [Homo sapiens]
Length = 1537
Score = 138 bits (348), Expect = 2e-32
Identities = 96/292 (32%), Positives = 140/292 (47%), Gaps = 2/292 (0%)
Query: 92 LVLRRNRFARLPPAVAELGHH--LTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPA 149
+ +R RL P G ++ LD SH L + EV + R L +L L NQ+
Sbjct: 1 MTTKRKIIGRLVPCRCFRGEEEIISVLDYSHCSLQQVPKEVFNFERTLEELYLDANQIEE 60
Query: 150 LPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEEL 209
LP QL L +L + N L++LP +++ L L+ LD+ N + FP + L +
Sbjct: 61 LPKQLFNCQALRKLSIPDNDLSNLPTTIASLVNLKELDISKNGVQEFPENIKCCKCLTII 120
Query: 210 DVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQF 269
+ S N + LP+ + L L L+L+ A L LPA F L L L L N L+ LP
Sbjct: 121 EASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRILELRENHLKTLPKSM 180
Query: 270 SCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNN 329
L +L+ L+L +N F E P L + L EL++ N L +P I L L+ L + N
Sbjct: 181 HKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKN 240
Query: 330 RIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPP 381
RI + I LE+L+L N + LPD G L ++ K+ DN L P
Sbjct: 241 RIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLP 292
Score = 135 bits (341), Expect = 2e-31
Identities = 113/358 (31%), Positives = 169/358 (47%), Gaps = 33/358 (9%)
Query: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNR-- 122
+E L L N +EE+P+ L + +LR L + N + LP +A L + L ELD+S N
Sbjct: 48 LEELYLDANQIEELPKQLFNCQ-ALRKLSIPDNDLSNLPTTIASLVN-LKELDISKNGVQ 105
Query: 123 -----------LTALGAEV---------VSALRELRKLNLSHNQLPALPAQLGALAHLEE 162
LT + A V + L L +L L+ L LPA G L L
Sbjct: 106 EFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGRLVKLRI 165
Query: 163 LDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPED 222
L++ N L LP S+ L++L LD+ +N+ P L Q+ L EL + +N L+ LP
Sbjct: 166 LELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWMDNNALQVLPGS 225
Query: 223 ISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSS 282
I L+ L L +S + T+ +LE L+L +N LQ LP L++L L +
Sbjct: 226 IGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDD 285
Query: 283 NLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELT 342
N P + L+ LEE S N+L S+PS I L L TL +D N + LP I
Sbjct: 286 NQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCK 345
Query: 343 GLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELA 400
+ + L+ N++ LP+ GQ+ ++ + + DN L K +P+ KELA
Sbjct: 346 NVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRL---------KNLPFSFTKLKELA 394
Score = 134 bits (336), Expect = 6e-31
Identities = 99/316 (31%), Positives = 153/316 (48%), Gaps = 3/316 (0%)
Query: 60 ANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVS 119
A+L +++ L++ NG++E PE + L ++ N ++LP +L +LT+L ++
Sbjct: 89 ASLVNLKELDISKNGVQEFPENI-KCCKCLTIIEASVNPISKLPDGFTQL-LNLTQLYLN 146
Query: 120 HNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSC 179
L L A L +LR L L N L LP + LA LE LD+ N LP+ L
Sbjct: 147 DAFLEFLPANF-GRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQ 205
Query: 180 LSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAEL 239
+ LR L +D+N L P + +L L LD+S NR+ + DIS AL+ L LS L
Sbjct: 206 IQNLRELWMDNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNML 265
Query: 240 GTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLE 299
LP L L +L +D+N L LP L L+ + S N E P+ + L L
Sbjct: 266 QQLPDSIGLLKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLR 325
Query: 300 ELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPD 359
L + N L +P I + + L +N++ +LP+ I ++ L L L N++ LP
Sbjct: 326 TLAVDENFLPELPREIGSCKNVTVMSLRSNKLEFLPEEIGQMQKLRVLNLSDNRLKNLPF 385
Query: 360 HFGQLSRVGLWKIKDN 375
F +L + + DN
Sbjct: 386 SFTKLKELAALWLSDN 401
Score = 130 bits (327), Expect = 6e-30
Identities = 92/307 (29%), Positives = 148/307 (48%), Gaps = 24/307 (7%)
Query: 101 RLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHL 160
++P V L EL + N++ L ++ + + LRKL++ N L LP + +L +L
Sbjct: 36 QVPKEVFNFERTLEELYLDANQIEELPKQLFNC-QALRKLSIPDNDLSNLPTTIASLVNL 94
Query: 161 EELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFP---RQLL---------------- 201
+ELD+S N + P+++ C L ++ N ++ P QLL
Sbjct: 95 KELDISKNGVQEFPENIKCCKCLTIIEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLP 154
Query: 202 ----QLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLML 257
+LV L L++ N L+ LP+ + L L+ L L E G LP ++ +L L +
Sbjct: 155 ANFGRLVKLRILELRENHLKTLPKSMHKLAQLERLDLGNNEFGELPEVLDQIQNLRELWM 214
Query: 258 DNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISG 317
DNN LQ LP L+ L L++S N E + LE+L LS N L +P I
Sbjct: 215 DNNALQVLPGSIGKLKMLVYLDMSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGL 274
Query: 318 LGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPL 377
L +L TL +D+N++ LP++I L+ LEE N++ LP G L + + +N L
Sbjct: 275 LKKLTTLKVDDNQLTMLPNTIGNLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFL 334
Query: 378 IQPPYEV 384
+ P E+
Sbjct: 335 PELPREI 341
Score = 124 bits (312), Expect = 4e-28
Identities = 96/286 (33%), Positives = 136/286 (47%), Gaps = 29/286 (10%)
Query: 48 LESPASPQLVLP---ANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPP 104
+E+ +P LP L ++ L L + LE +P G L LR+L LR N LP
Sbjct: 120 IEASVNPISKLPDGFTQLLNLTQLYLNDAFLEFLPANFGR-LVKLRILELRENHLKTLPK 178
Query: 105 AVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELD 164
++ +L L LD+ +N L EV+ ++ LR+L + +N L LP +G L L LD
Sbjct: 179 SMHKLAQ-LERLDLGNNEFGEL-PEVLDQIQNLRELWMDNNALQVLPGSIGKLKMLVYLD 236
Query: 165 VSFNR-----------------------LAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLL 201
+S NR L LPDS+ L +L TL VD NQLT P +
Sbjct: 237 MSKNRIETVDMDISGCEALEDLLLSSNMLQQLPDSIGLLKKLTTLKVDDNQLTMLPNTIG 296
Query: 202 QLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNG 261
L LEE D S N L LP I L +L+ L + L LP ++ + L +N
Sbjct: 297 NLSLLEEFDCSCNELESLPSTIGYLHSLRTLAVDENFLPELPREIGSCKNVTVMSLRSNK 356
Query: 262 LQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQ 307
L+ LP + +Q+L++LNLS N + P + L L L+LS NQ
Sbjct: 357 LEFLPEEIGQMQKLRVLNLSDNRLKNLPFSFTKLKELAALWLSDNQ 402
>gi|4503743 flightless I homolog [Homo sapiens]
Length = 1269
Score = 131 bits (329), Expect = 4e-30
Identities = 116/358 (32%), Positives = 160/358 (44%), Gaps = 58/358 (16%)
Query: 79 PEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELR 138
PE + A+ SLR L L R LP +A L L L VSHN LT L E+ S+L LR
Sbjct: 26 PENV-KAMTSLRWLKLNRTGLCYLPEELAAL-QKLEHLSVSHNNLTTLHGEL-SSLPSLR 82
Query: 139 KLNLSHNQLP--ALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAF 196
+ N L +P + L L LD+S N+L P L + L++ HN +
Sbjct: 83 AIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTI 142
Query: 197 PRQL-LQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAEL---------------- 239
P QL + L L LD+S NRL LP + L L+ L L+G L
Sbjct: 143 PNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQT 202
Query: 240 ----------GTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFP 289
LP L++L + L N L +P L L+ LNLSSN E
Sbjct: 203 LHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELS 262
Query: 290 AALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRY--LPDSIVELTGLEE- 346
+ +E L LSRNQLTS+PS I L +L L+L++N++ + LP I +LT LEE
Sbjct: 263 LCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNKLDFDGLPSGIGKLTNLEEF 322
Query: 347 ----------------------LVLQGNQIAVLPDHFGQLSRVGLWKIKDNP-LIQPP 381
LVL N + LP+ L+ + + +++NP L+ PP
Sbjct: 323 MAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLTEIEVLDVRENPNLVMPP 380
Score = 108 bits (271), Expect = 2e-23
Identities = 83/256 (32%), Positives = 126/256 (49%), Gaps = 5/256 (1%)
Query: 61 NLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSH 120
N ++ LNL +N ++ +P L L L L L NR LPP + L H L L ++
Sbjct: 125 NAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVH-LQTLVLNG 183
Query: 121 NRLTALGAEVVSALRELRKLNLSHNQLPA--LPAQLGALAHLEELDVSFNRLAHLPDSLS 178
N L + A+ L+ L+L Q LP L L++L ++D+S N L +P+ L
Sbjct: 184 NPLLHAQLRQLPAMTALQTLHLRSTQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLY 243
Query: 179 CLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAE 238
L LR L++ NQ+T + Q V +E L++S N+L LP I L LK L+L+ +
Sbjct: 244 TLPSLRRLNLSSNQITELSLCIDQWVHVETLNLSRNQLTSLPSAICKLSKLKKLYLNSNK 303
Query: 239 L--GTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLA 296
L LP+G +L +LE M NN L+ +P +L+ L L+ N P A+ L
Sbjct: 304 LDFDGLPSGIGKLTNLEEFMAANNNLELVPESLCRCPKLRKLVLNKNHLVTLPEAIHFLT 363
Query: 297 GLEELYLSRNQLTSVP 312
+E L + N +P
Sbjct: 364 EIEVLDVRENPNLVMP 379
Score = 100 bits (250), Expect = 6e-21
Identities = 85/263 (32%), Positives = 119/263 (45%), Gaps = 6/263 (2%)
Query: 129 EVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDV 188
E V A+ LR L L+ L LP +L AL LE L VS N L L LS L LR +
Sbjct: 27 ENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHLSVSHNNLTTLHGELSSLPSLRAIVA 86
Query: 189 DHNQL--TAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAG- 245
N L + P + +L L LD+S N+L P ++ + + +L LS + T+P
Sbjct: 87 RANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPRELENAKNMLVLNLSHNSIDTIPNQL 146
Query: 246 FCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLP-LAGLEELYLS 304
F L L L L N L++LP Q L L+ L L+ N LP + L+ L+L
Sbjct: 147 FINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVLNGNPLLHAQLRQLPAMTALQTLHLR 206
Query: 305 RNQLT--SVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFG 362
Q T ++P+ + GL L + L N + +P+ + L L L L NQI L
Sbjct: 207 STQRTQSNLPTSLEGLSNLADVDLSCNDLTRVPECLYTLPSLRRLNLSSNQITELSLCID 266
Query: 363 QLSRVGLWKIKDNPLIQPPYEVC 385
Q V + N L P +C
Sbjct: 267 QWVHVETLNLSRNQLTSLPSAIC 289
Score = 70.1 bits (170), Expect = 1e-11
Identities = 57/185 (30%), Positives = 89/185 (48%), Gaps = 5/185 (2%)
Query: 175 DSLSCLSRLRTLDVDHNQLTA--FPRQLLQLVALEELDVSSNRLRGLPEDISALRALKIL 232
++ L +R +D+ N FP + + +L L ++ L LPE+++AL+ L+ L
Sbjct: 2 EATGVLPFVRGVDLSGNDFKGGYFPENVKAMTSLRWLKLNRTGLCYLPEELAALQKLEHL 61
Query: 233 WLSGAELGTLPAGFCELASLESLMLDNNGLQ--ALPAQFSCLQRLKMLNLSSNLFEEFPA 290
+S L TL L SL +++ N L+ +P L L +L+LS N E P
Sbjct: 62 SVSHNNLTTLHGELSSLPSLRAIVARANSLKNSGVPDDIFKLDDLSVLDLSHNQLTECPR 121
Query: 291 ALLPLAGLEELYLSRNQLTSVPS-LISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVL 349
L + L LS N + ++P+ L L LL L L NR+ LP + L L+ LVL
Sbjct: 122 ELENAKNMLVLNLSHNSIDTIPNQLFINLTDLLYLDLSENRLESLPPQMRRLVHLQTLVL 181
Query: 350 QGNQI 354
GN +
Sbjct: 182 NGNPL 186
>gi|171846278 leucine-rich repeat kinase 2 [Homo sapiens]
Length = 2527
Score = 127 bits (319), Expect = 6e-29
Identities = 181/731 (24%), Positives = 304/731 (41%), Gaps = 119/731 (16%)
Query: 17 DAALRARKLRSNLRQLTLTAAGACPGAGADALESPA---------SPQLVLPANLGDIEA 67
D +LR+ KL+S++R ++ A +L+ A S + + +L +E
Sbjct: 956 DDSLRSSKLQSHMRHSDSISSLASEREYITSLDLSANELRDIDALSQKCCISVHLEHLEK 1015
Query: 68 LNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRL-TAL 126
L L N L P+ L L SL L L N+F P + ++ + LDVS N + ++
Sbjct: 1016 LELHQNALTSFPQQLCETLKSLTHLDLHSNKFTSFPSYLLKMSC-IANLDVSRNDIGPSV 1074
Query: 127 GAEVVSALRELRKLNLSHNQLPALPAQL-GALAHLEELDVSFNRLAHLPDSLSCLSRLRT 185
+ L++ NLS+NQL +P L + LE+L + N+++ + L L L+
Sbjct: 1075 VLDPTVKCPTLKQFNLSYNQLSFVPENLTDVVEKLEQLILEGNKISGICSPLR-LKELKI 1133
Query: 186 LDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAG 245
L++ N +++ L+ A +++ S R+ L ++ IL LS + +P
Sbjct: 1134 LNLSKNHISSLSENFLE--ACPKVESFSARMNFLAAMPFLPPSMTILKLSQNKFSCIPEA 1191
Query: 246 FCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAG-------L 298
L L SL + +N +Q LP K LNL LF ++L L+ +
Sbjct: 1192 ILNLPHLRSLDMSSNDIQYLPGP----AHWKSLNLRELLFSHNQISILDLSEKAYLWSRV 1247
Query: 299 EELYLSRNQLTSVPSLISGLGRLLTLWLDNN-RIRYLPDSIVELTGLEELVLQGNQIAVL 357
E+L+LS N+L +P I L L +L + N +R P+ + +L+ + +L L +
Sbjct: 1248 EKLHLSHNKLKEIPPEIGCLENLTSLDVSYNLELRSFPNEMGKLSKIWDLPLDELHLNFD 1307
Query: 358 PDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLLLMGH 417
H G K KD +I+ + K +PY R+KL+++G+
Sbjct: 1308 FKHIG-------CKAKD--IIRFLQQRLKKAVPY----------------NRMKLMIVGN 1342
Query: 418 KAAGKTLLRHCLTEERVEGCPGGGDKEKCYPPSPPPVSKGIEVTSWTADA----SRGLRF 473
+GKT L L K K + GI+V W R L
Sbjct: 1343 TGSGKTTLLQQLM------------KTKKSDLGMQSATVGIDVKDWPIQIRDKRKRDLVL 1390
Query: 474 IVYDLAGDESYEVIQPFFLSPGALYVLVVNLATYEPRHFPTTVGSFLHRVGARVPHAVVC 533
V+D AG E + P F++ ALY+ V +L+ + + +L + AR + V
Sbjct: 1391 NVWDFAGREEFYSTHPHFMTQRALYLAVYDLSKGQAE--VDAMKPWLFNIKARASSSPVI 1448
Query: 534 IVGTHADLCGERELEEKCLDIHRQIALQEKHDAEGLSRLAKVVDEALARDFELRSASPHA 593
+VGTH D+ E++ + I +++ + A RD+ +A+
Sbjct: 1449 LVGTHLDVSDEKQRKACMSKITKELLNKRGFPA--------------IRDYHFVNATEE- 1493
Query: 594 AYYGVSDKNLRRRKAHFQYLLNHRLQILSPVLPVSCRDPRHLRRLRDKLLSVAEHREI-F 652
SD + RK LN +++ L V P L +LS ++ I F
Sbjct: 1494 -----SDALAKLRKTIINESLNFKIR---DQLVVGQLIPDCYVELEKIILSERKNVPIEF 1545
Query: 653 PNLHRVLPRSWQVLEELHFQPPQAQRLWLSWWDSARLGLQAGLTEDRLQSALSYLHESGK 712
P + R R Q++ E Q L E+ L A+ +L+ESG
Sbjct: 1546 PVIDR--KRLLQLVRENQLQ----------------------LDENELPHAVHFLNESGV 1581
Query: 713 LLYFEDSPALK 723
LL+F+D PAL+
Sbjct: 1582 LLHFQD-PALQ 1591
>gi|90991702 leucine-rich repeat kinase 1 [Homo sapiens]
Length = 2015
Score = 126 bits (316), Expect = 1e-28
Identities = 181/694 (26%), Positives = 281/694 (40%), Gaps = 100/694 (14%)
Query: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAE---LGHHLTELDVSHN 121
I L+L N L +P + L +LR L L N LP + + L E+D+S N
Sbjct: 280 ITELDLSANCLATLPSVIPWGLINLRKLNLSDNHLGELPGVQSSDEIICSRLLEIDISSN 339
Query: 122 RLTALGAEVVSALRELRKLNLSHNQLPALPAQLGA-----LAHLEELDVSFNRLAHLPDS 176
+L+ L + L +L+KL S N L L + A L L+ELD+S N+L LP
Sbjct: 340 KLSHLPPGFLH-LSKLQKLTASKNCLEKLFEEENATNWIGLRKLQELDISDNKLTELPAL 398
Query: 177 -LSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISAL--RALKILW 233
L L +L+V N L FP L+ S N L LP+ ++ LK +
Sbjct: 399 FLHSFKSLNSLNVSRNNLKVFPDPWA--CPLKCCKASRNALECLPDKMAVFWKNHLKDVD 456
Query: 234 LSGAELGTLPAGFCELASLESLMLDNNGLQALPAQ--FSCLQRLKMLNLSSNLFEEFP-- 289
S L +P G +L +L L L N L ALP Q ++C Q LK L+LS N +
Sbjct: 457 FSENALKEVPLGLFQLDALMFLRLQGNQLAALPPQEKWTCRQ-LKTLDLSRNQLGKNEDG 515
Query: 290 -----AALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGL 344
A G + + P+ +S L L L++N + +P S+ L L
Sbjct: 516 LKTKRIAFFTTRGRQRSGTEAASVLEFPAFLSE--SLEVLCLNDNHLDTVPPSVCLLKSL 573
Query: 345 EELVLQGNQ-IAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQ 403
EL L N + LP GQL + +D + P E+ +G + +Y + A +
Sbjct: 574 SELYLGNNPGLRELPPELGQLGNLWQLDTEDLTISNVPAEIQKEGPKAMLSYLR--AQLR 631
Query: 404 PAVQPRL-KLLLMGHKAAGKTLLRHCLTEERVEGCPGGGDKEKCYPPSPPPVSKG---IE 459
A + +L K++++G GK+ L L R P V G I
Sbjct: 632 KAEKCKLMKMIIVGPPRQGKSTLLEILQTGRA-----------------PQVVHGEATIR 674
Query: 460 VTSWTADASRGLR-------FIVYDLAGDESYEVIQPFFLSPGALYVLVVNLATYEPRHF 512
T W G R F V+D+ G S + F + ALYV+V NLA E
Sbjct: 675 TTKWELQRPAGSRAKVESVEFNVWDIGGPASMATVNQCFFTDKALYVVVWNLALGE--EA 732
Query: 513 PTTVGSFLHRVGARVPHAVVCIVGTHADLCGERELEEKCLDIHRQI-ALQEKHDAEGLSR 571
+ +L + A+ P+AVV +VGTH DL + E+ + + AL +
Sbjct: 733 VANLQFWLLNIEAKAPNAVVLVVGTHLDLIEAKFRVERIATLRAYVLALCRSPSGSRATG 792
Query: 572 LAKVVDEALARDFELRSASPHAAYYGVSDKNLRRRKAHFQYLLNHRLQILSPVLPVSCRD 631
+ + L + +S K+L ++ Q + + + + C+
Sbjct: 793 FPDITFKHL---------------HEISCKSLEGQEGLRQLIFHVTCSMKDVGSTIGCQR 837
Query: 632 ------PRHLRRLRDKLLSVAEHREIFPNLHRVLPRSWQVLEELHFQPPQAQRLWLSWWD 685
PR L++ +L+ + R ++ + R LE+L Q P
Sbjct: 838 LAGRLIPRSYLSLQEAVLAEQQRRSRDDDVQYLTDRQ---LEQLVEQTPDNDI------- 887
Query: 686 SARLGLQAGLTEDRLQSALSYLHESGKLLYFEDS 719
+ LQSA+S+L E+G LL+F D+
Sbjct: 888 ---------KDYEDLQSAISFLIETGTLLHFPDT 912
>gi|157743290 leucine rich repeat containing 30 [Homo sapiens]
Length = 301
Score = 120 bits (301), Expect = 7e-27
Identities = 81/243 (33%), Positives = 122/243 (50%), Gaps = 11/243 (4%)
Query: 170 LAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRAL 229
+ +PD L LS ++ L++ HNQL P ++ +L + L++ NRL+ LP ++S L+ L
Sbjct: 60 MTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPREVSLLQCL 119
Query: 230 KILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFP 289
K+L+++ L +PA LE L L +N L LPA F+ L RL+ LNLS+N F P
Sbjct: 120 KVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLSNNFFAHIP 179
Query: 290 AALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVL 349
+ L L L++ N+L ++ I L L + N I P S+ +T LE L L
Sbjct: 180 MCVFSLKELIFLHVGSNRLENIAESIQHLASLQIFIAEGNNIHSFPRSLCLVTSLELLNL 239
Query: 350 QGNQIAVLPDHFGQLSRV----------GLWKIKDNPLIQPPYEVCMKGIPYIAAYQKEL 399
N I LP L R+ GL I NPL +P E+ G+ + Y K+
Sbjct: 240 NNNDIQTLPSELHLLCRLVRIAWNPMDKGL-HISHNPLSKPLPELVEGGLEMLFGYLKDK 298
Query: 400 AHS 402
H+
Sbjct: 299 KHT 301
Score = 45.8 bits (107), Expect = 2e-04
Identities = 36/122 (29%), Positives = 56/122 (45%)
Query: 254 SLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPS 313
S L G+ +P L ++ LNLS N P + L + L L N+L S+P
Sbjct: 52 SFSLVTRGMTDIPDFLWGLSEVQKLNLSHNQLRVLPPEVGKLTRIVVLNLCGNRLKSLPR 111
Query: 314 LISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGLWKIK 373
+S L L L+++ N + +P + LE L L N ++ LP F LSR+ +
Sbjct: 112 EVSLLQCLKVLFVNMNCLTEVPAELSLCRKLEVLSLSHNCLSQLPACFADLSRLRKLNLS 171
Query: 374 DN 375
+N
Sbjct: 172 NN 173
>gi|153792305 leucine rich repeat containing 58 [Homo sapiens]
Length = 371
Score = 119 bits (298), Expect = 1e-26
Identities = 90/240 (37%), Positives = 121/240 (50%), Gaps = 24/240 (10%)
Query: 121 NRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGA-LAHLEELDVSFNRLAHLPDSLSC 179
+ L A G E A L +L L HN+L +LP LG+ HL+ LDVS N L L L
Sbjct: 30 SELEARGEERRGAREALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLA 89
Query: 180 LSRLRTLDVDHNQL---TAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSG 236
L LRTL +N+L +A P+ L Q R+L++L LSG
Sbjct: 90 LRGLRTLLAKNNRLGGPSALPKGLAQ--------------------SPLCRSLQVLNLSG 129
Query: 237 AELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLA 296
+PA EL +L++L L N LQ++PA+ LQ L+ L L N +E P L L
Sbjct: 130 NCFQEVPASLLELRALQTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLP 189
Query: 297 GLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAV 356
L L L N++ S+P +S L L +L L NN + YLP I+ L LEEL L+GN + V
Sbjct: 190 SLNYLVLCDNKIQSIPPQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVV 249
Score = 96.3 bits (238), Expect = 1e-19
Identities = 76/237 (32%), Positives = 109/237 (45%), Gaps = 33/237 (13%)
Query: 183 LRTLDVDHNQLTAFPRQLLQ-LVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGT 241
L L + HN+L + PR L L+ LDVS N L L ++ ALR L+ L LG
Sbjct: 46 LLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALRGLRTLLAKNNRLG- 104
Query: 242 LPAGFCELASLESLMLDNNGLQALP---AQFSCLQRLKMLNLSSNLFEEFPAALLPLAGL 298
G ALP AQ + L++LNLS N F+E PA+LL L L
Sbjct: 105 -------------------GPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRAL 145
Query: 299 EELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLP 358
+ L L NQL S+P+ I L L L+L N I+ +P + L L LVL N+I +P
Sbjct: 146 QTLSLGGNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIP 205
Query: 359 DHFGQLSRVGLWKIKDNPLIQPPYEV---------CMKGIPYIAAYQKELAHSQPAV 406
QL + + +N L P E+ ++G P + + ++L + P +
Sbjct: 206 PQLSQLHSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPLVVRFVRDLTYDPPTL 262
Score = 76.6 bits (187), Expect = 1e-13
Identities = 70/216 (32%), Positives = 94/216 (43%), Gaps = 28/216 (12%)
Query: 75 LEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVV--- 131
LE E A +L L+L NR LP A+ HL LDVS N LTALG E++
Sbjct: 32 LEARGEERRGAREALLRLLLPHNRLVSLPRALGSGFPHLQLLDVSGNALTALGPELLALR 91
Query: 132 ---------------SAL----------RELRKLNLSHNQLPALPAQLGALAHLEELDVS 166
SAL R L+ LNLS N +PA L L L+ L +
Sbjct: 92 GLRTLLAKNNRLGGPSALPKGLAQSPLCRSLQVLNLSGNCFQEVPASLLELRALQTLSLG 151
Query: 167 FNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISAL 226
N+L +P + L L L + N + P +L L +L L + N+++ +P +S L
Sbjct: 152 GNQLQSIPAEIENLQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQL 211
Query: 227 RALKILWLSGAELGTLPAGFCELASLESLMLDNNGL 262
+L+ L L L LP L LE L L N L
Sbjct: 212 HSLRSLSLHNNLLTYLPREILNLIHLEELSLRGNPL 247
Score = 63.5 bits (153), Expect = 1e-09
Identities = 49/152 (32%), Positives = 73/152 (48%), Gaps = 26/152 (17%)
Query: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLT 124
++ LNL N +EVP L L LR L L + N+L
Sbjct: 122 LQVLNLSGNCFQEVPASL---------LELRA----------------LQTLSLGGNQLQ 156
Query: 125 ALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLR 184
++ AE+ + L+ L L L N + +P +LG L L L + N++ +P LS L LR
Sbjct: 157 SIPAEIEN-LQSLECLYLGGNFIKEIPPELGNLPSLNYLVLCDNKIQSIPPQLSQLHSLR 215
Query: 185 TLDVDHNQLTAFPRQLLQLVALEELDVSSNRL 216
+L + +N LT PR++L L+ LEEL + N L
Sbjct: 216 SLSLHNNLLTYLPREILNLIHLEELSLRGNPL 247
Score = 52.0 bits (123), Expect = 3e-06
Identities = 35/87 (40%), Positives = 52/87 (59%), Gaps = 3/87 (3%)
Query: 61 NLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSH 120
NL +E L LG N ++E+P LG+ L SL LVL N+ +PP +++L H L L + +
Sbjct: 164 NLQSLECLYLGGNFIKEIPPELGN-LPSLNYLVLCDNKIQSIPPQLSQL-HSLRSLSLHN 221
Query: 121 NRLTALGAEVVSALRELRKLNLSHNQL 147
N LT L E+++ L L +L+L N L
Sbjct: 222 NLLTYLPREILN-LIHLEELSLRGNPL 247
>gi|4758460 glycoprotein V (platelet) [Homo sapiens]
Length = 560
Score = 115 bits (289), Expect = 2e-25
Identities = 122/385 (31%), Positives = 175/385 (45%), Gaps = 47/385 (12%)
Query: 18 AALRARKLRSNLRQLTLTAAGACPGAGADALESPASPQLVLPANLGDIEALNLGNNGLEE 77
A + A L +NL + L G G L+S + + + ++ L + ++ +
Sbjct: 41 ARISALGLPTNLTHILLF------GMGRGVLQSQSFSGMTV------LQRLMISDSHISA 88
Query: 78 VPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALREL 137
V G S L L+ L L RN+ LP A+ + L +L + HN L + + L L
Sbjct: 89 VAPGTFSDLIKLKTLRLSRNKITHLPGALLDKMVLLEQLFLDHNALRGIDQNMFQKLVNL 148
Query: 138 RKLNLSHNQLPALPAQLGA-LAHLEELDVSFNRLAHLPDS-LSCLSRLRTLDVDHNQLTA 195
++L L+ NQL LPA L L +L+ LD+S N L HLP L ++L L + N+L +
Sbjct: 149 QELALNQNQLDFLPASLFTNLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVS 208
Query: 196 FPRQLL-QLVALEELDVSSNRLRGL-PEDISALRALKILWLSGAELGTLPAG-------- 245
LL L AL EL N +R + P L L L LS L LP+
Sbjct: 209 LDSGLLNSLGALTELQFHRNHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNL 268
Query: 246 -----------------FCELASLESLMLDNNGLQALP-AQFSCLQRLKML--NLSSNLF 285
F E+ L+ L L+ L+ LP A F L RL+ L LS L
Sbjct: 269 TLLTLFENPLAELPGVLFGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGVTLSPRLS 328
Query: 286 EEFPAALLPLAGLEELYLSRNQLTSVP-SLISGLGRLLTLWLDNNRIRYLPDSIV-ELTG 343
A L L+ L L N LT++P L+ GLG+L + L NR+R LP ++ L+
Sbjct: 329 ALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALFRNLSS 388
Query: 344 LEELVLQGNQIAVLP-DHFGQLSRV 367
LE + L NQ+ LP D FG L R+
Sbjct: 389 LESVQLDHNQLETLPGDVFGALPRL 413
Score = 87.4 bits (215), Expect = 6e-17
Identities = 88/281 (31%), Positives = 124/281 (44%), Gaps = 33/281 (11%)
Query: 61 NLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSH 120
NL +++ L+L N L +P+GL A L L+L NR L + LTEL
Sbjct: 168 NLENLKLLDLSGNNLTHLPKGLLGAQAKLERLLLHSNRLVSLDSGLLNSLGALTELQFHR 227
Query: 121 NRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAH-LEELDVSFNRLAHLPDSLSC 179
N + ++ L L L LS N L LP+ L +H L L + N LA LP L
Sbjct: 228 NHIRSIAPGAFDRLPNLSSLTLSRNHLAFLPSALFLHSHNLTLLTLFENPLAELPGVL-- 285
Query: 180 LSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLP----EDISALRALKILWLS 235
++ L+EL ++ +LR LP ++S LR L +
Sbjct: 286 --------------------FGEMGGLQELWLNRTQLRTLPAAAFRNLSRLRYLGV--TL 323
Query: 236 GAELGTLPAG-FCELASLESLMLDNNGLQALP-AQFSCLQRLKMLNLSSNLFEEFPAALL 293
L LP G F L L+ L L +NGL ALP L +L+ ++L N P AL
Sbjct: 324 SPRLSALPQGAFQGLGELQVLALHSNGLTALPDGLLRGLGKLRQVSLRRNRLRALPRALF 383
Query: 294 -PLAGLEELYLSRNQLTSVPSLISG-LGRLLTLWLDNNRIR 332
L+ LE + L NQL ++P + G L RL + L +N R
Sbjct: 384 RNLSSLESVQLDHNQLETLPGDVFGALPRLTEVLLGHNSWR 424
>gi|223005922 leucine rich repeat containing 10-like [Homo sapiens]
Length = 292
Score = 113 bits (283), Expect = 8e-25
Identities = 70/177 (39%), Positives = 99/177 (55%)
Query: 138 RKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFP 197
++L LS +L LP+ + AL+ L++L VS L LP+ + L LR L +D N+L P
Sbjct: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
Query: 198 RQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLML 257
L +L L L + NRL LP D + L++L+ LW+ G L P L +L+SL +
Sbjct: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
Query: 258 DNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSL 314
+N L+ALPA+ + L+ L L N FEEFP ALL + L L L RN+L P L
Sbjct: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPDL 200
Score = 108 bits (269), Expect = 3e-23
Identities = 69/196 (35%), Positives = 99/196 (50%), Gaps = 1/196 (0%)
Query: 186 LDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAG 245
L++ +L P + L L++L VS LR LPE+I LR L+IL L +L LP G
Sbjct: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
Query: 246 FCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSR 305
C L L L L N L ALPA F+ LQ L+ L + N FP LL L L+ L +
Sbjct: 86 LCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGD 145
Query: 306 NQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLS 365
N+L ++P+ + + L LWL NR P +++ + L L L N++ PD L
Sbjct: 146 NRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPD-LHPLR 204
Query: 366 RVGLWKIKDNPLIQPP 381
+ ++ NP+ PP
Sbjct: 205 ALRVFSYDHNPVTGPP 220
Score = 99.4 bits (246), Expect = 2e-20
Identities = 71/175 (40%), Positives = 86/175 (49%), Gaps = 2/175 (1%)
Query: 92 LVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALP 151
L L R RLP AV L L +L VS L L E+ LRELR L L N+L LP
Sbjct: 26 LELSGRRLRRLPSAVCALSR-LQKLYVSGTGLRELPEEI-EELRELRILALDFNKLERLP 83
Query: 152 AQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDV 211
L L L L + NRL LP + L LR L ++ N L FPR LL+LVAL+ L +
Sbjct: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
Query: 212 SSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALP 266
NRLR LP ++ + L+ LWL G P + L L LD N L P
Sbjct: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP 198
Score = 96.3 bits (238), Expect = 1e-19
Identities = 61/176 (34%), Positives = 88/176 (50%)
Query: 161 EELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLP 220
++L++S RL LP ++ LSRL+ L V L P ++ +L L L + N+L LP
Sbjct: 24 QQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
Query: 221 EDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNL 280
+ + L L L+L G L LPA F +L SL L ++ N L+ P L L+ L +
Sbjct: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
Query: 281 SSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPD 336
N PA L + GL L+L N+ P + +GRL L LD NR+ PD
Sbjct: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFPD 199
Score = 88.2 bits (217), Expect = 4e-17
Identities = 68/198 (34%), Positives = 91/198 (45%), Gaps = 2/198 (1%)
Query: 115 ELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLP 174
+L++S RL L + V AL L+KL +S L LP ++ L L L + FN+L LP
Sbjct: 25 QLELSGRRLRRLPS-AVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLP 83
Query: 175 DSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWL 234
D L L RL L + N+L A P QL +L L + N LR P + L AL+ L +
Sbjct: 84 DGLCRLPRLTRLYLGGNRLLALPADFAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQM 143
Query: 235 SGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLP 294
L LPA + L L L N + P + RL +L+L N FP L P
Sbjct: 144 GDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP-DLHP 202
Query: 295 LAGLEELYLSRNQLTSVP 312
L L N +T P
Sbjct: 203 LRALRVFSYDHNPVTGPP 220
Score = 83.2 bits (204), Expect = 1e-15
Identities = 64/170 (37%), Positives = 89/170 (52%), Gaps = 4/170 (2%)
Query: 62 LGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHN 121
L ++ L + GL E+PE + L LR+L L N+ RLP + L LT L + N
Sbjct: 43 LSRLQKLYVSGTGLRELPEEI-EELRELRILALDFNKLERLPDGLCRL-PRLTRLYLGGN 100
Query: 122 RLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLS 181
RL AL A+ + L+ LR L + N L P L L L+ L + NRL LP L ++
Sbjct: 101 RLLALPAD-FAQLQSLRCLWIEGNFLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMT 159
Query: 182 RLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKI 231
LR L + N+ FP LL++ L LD+ NRL G P D+ LRAL++
Sbjct: 160 GLRGLWLYGNRFEEFPPALLRMGRLHILDLDRNRLGGFP-DLHPLRALRV 208
Score = 56.2 bits (134), Expect = 2e-07
Identities = 49/176 (27%), Positives = 72/176 (40%), Gaps = 24/176 (13%)
Query: 232 LWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAA 291
L LSG L LP+ C L+ L+ L + GL+ LP + L+ L++L L N E P
Sbjct: 26 LELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLERLPDG 85
Query: 292 LLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQG 351
L L RL L+L NR+ LP +L L L ++G
Sbjct: 86 LCRLP-----------------------RLTRLYLGGNRLLALPADFAQLQSLRCLWIEG 122
Query: 352 NQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEV-CMKGIPYIAAYQKELAHSQPAV 406
N + P +L + ++ DN L P E+ M G+ + Y PA+
Sbjct: 123 NFLRRFPRPLLRLVALQSLQMGDNRLRALPAELPRMTGLRGLWLYGNRFEEFPPAL 178
Score = 46.6 bits (109), Expect = 1e-04
Identities = 29/86 (33%), Positives = 45/86 (52%)
Query: 296 AGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIA 355
+G ++L LS +L +PS + L RL L++ +R LP+ I EL L L L N++
Sbjct: 21 SGDQQLELSGRRLRRLPSAVCALSRLQKLYVSGTGLRELPEEIEELRELRILALDFNKLE 80
Query: 356 VLPDHFGQLSRVGLWKIKDNPLIQPP 381
LPD +L R+ + N L+ P
Sbjct: 81 RLPDGLCRLPRLTRLYLGGNRLLALP 106
Score = 43.5 bits (101), Expect = 0.001
Identities = 32/87 (36%), Positives = 44/87 (50%), Gaps = 4/87 (4%)
Query: 65 IEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLT 124
+++L +G+N L +P L G LR L L NRF PPA+ +G L LD+ NRL
Sbjct: 138 LQSLQMGDNRLRALPAELPRMTG-LRGLWLYGNRFEEFPPALLRMG-RLHILDLDRNRLG 195
Query: 125 ALGAEVVSALRELRKLNLSHNQLPALP 151
G + LR LR + HN + P
Sbjct: 196 --GFPDLHPLRALRVFSYDHNPVTGPP 220
>gi|205277468 leucine rich repeat containing 15 isoform a [Homo
sapiens]
Length = 587
Score = 112 bits (281), Expect = 1e-24
Identities = 111/329 (33%), Positives = 156/329 (47%), Gaps = 16/329 (4%)
Query: 61 NLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSH 120
NLG + L+L NN L+ +P GL L SL L+L N+ ++ PA +L EL +
Sbjct: 105 NLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHG 164
Query: 121 NRLTALGAEVVSALRELRKLNLSHNQLPAL-PAQLGALAHLEELDVSFNRLAHLP-DSLS 178
N L + L L KLNL N L + P L +L+ L + NRL +P +
Sbjct: 165 NHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFD 224
Query: 179 CLSRLRTLDVDHNQLTAF-PRQLLQLVALEELDVSSNRLRGLPEDI-SALRALKILWLSG 236
L L+ L + NQ+ P L+ L +S+N + LP I L L L L G
Sbjct: 225 GLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFG 284
Query: 237 AELGTLPAG-FCELASLESLMLDNNGLQALPAQ-FSCLQRLKMLNLSSNLFEEF-PAALL 293
L L G F + +L L L +N + +LP FS L++L++L LS N P A
Sbjct: 285 NSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFN 344
Query: 294 PLAGLEELYLSRNQLTSVP-SLISGLGRLLTLWLDNNRIRYLPDSI-VELTGLEELVLQG 351
L L EL L N L + ++ L L + L NNR+R LP +I + GL + LQ
Sbjct: 345 GLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQN 404
Query: 352 NQIAVLP----DHFGQLSRVGLWKIKDNP 376
NQ+ LP DH G+L + L+ DNP
Sbjct: 405 NQLENLPLGIFDHLGKLCELRLY---DNP 430
Score = 104 bits (259), Expect = 5e-22
Identities = 110/352 (31%), Positives = 165/352 (46%), Gaps = 19/352 (5%)
Query: 40 CPGAGADALESPASPQLVLPANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRF 99
C GA A+ +P LP N ++ LN L E P SAL +LR+ +N
Sbjct: 45 CTGARIVAVPTP------LPWNAMSLQILNTHITELNESPFLNISALIALRI---EKNEL 95
Query: 100 ARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPAL-PAQLGALA 158
+R+ P L L +++N+L L + L L L LS NQL + PA +
Sbjct: 96 SRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCS 155
Query: 159 HLEELDVSFNRLAHLPD-SLSCLSRLRTLDVDHNQLTAF-PRQLLQLVALEELDVSSNRL 216
+L+EL + N L ++PD + L L L++ N LT PR L L+ L + NRL
Sbjct: 156 NLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRL 215
Query: 217 RGLP-EDISALRALKILWLSGAELGTLPAG-FCELASLESLMLDNNGLQALPAQ-FSCLQ 273
+P L L+ L L ++G L G F +L+ L L NN + LP F L
Sbjct: 216 TDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLP 275
Query: 274 RLKMLNLSSNLFEEFPAALL-PLAGLEELYLSRNQLTSVP-SLISGLGRLLTLWLDNNRI 331
+L L L N +E + P+ L EL+L N ++S+P ++ S L +L L L N+I
Sbjct: 276 QLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQI 335
Query: 332 RYL-PDSIVELTGLEELVLQGNQIAVLPDH-FGQLSRVGLWKIKDNPLIQPP 381
++ P + LT L EL L N + L + F L+ + +++N L Q P
Sbjct: 336 SFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLP 387
Score = 43.9 bits (102), Expect = 8e-04
Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 2/104 (1%)
Query: 60 ANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVS 119
+NL ++ L L N + + G + L LR L L N L V + +L + +
Sbjct: 320 SNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQ 379
Query: 120 HNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEEL 163
+NRL L + + + L + L +NQL LP LG HL +L
Sbjct: 380 NNRLRQLPGNIFANVNGLMAIQLQNNQLENLP--LGIFDHLGKL 421
>gi|18677767 leucine rich repeat containing 15 isoform b [Homo
sapiens]
Length = 581
Score = 112 bits (281), Expect = 1e-24
Identities = 111/329 (33%), Positives = 156/329 (47%), Gaps = 16/329 (4%)
Query: 61 NLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSH 120
NLG + L+L NN L+ +P GL L SL L+L N+ ++ PA +L EL +
Sbjct: 99 NLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCSNLKELQLHG 158
Query: 121 NRLTALGAEVVSALRELRKLNLSHNQLPAL-PAQLGALAHLEELDVSFNRLAHLP-DSLS 178
N L + L L KLNL N L + P L +L+ L + NRL +P +
Sbjct: 159 NHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRLTDIPMGTFD 218
Query: 179 CLSRLRTLDVDHNQLTAF-PRQLLQLVALEELDVSSNRLRGLPEDI-SALRALKILWLSG 236
L L+ L + NQ+ P L+ L +S+N + LP I L L L L G
Sbjct: 219 GLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLPQLNRLTLFG 278
Query: 237 AELGTLPAG-FCELASLESLMLDNNGLQALPAQ-FSCLQRLKMLNLSSNLFEEF-PAALL 293
L L G F + +L L L +N + +LP FS L++L++L LS N P A
Sbjct: 279 NSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQISFISPGAFN 338
Query: 294 PLAGLEELYLSRNQLTSVP-SLISGLGRLLTLWLDNNRIRYLPDSI-VELTGLEELVLQG 351
L L EL L N L + ++ L L + L NNR+R LP +I + GL + LQ
Sbjct: 339 GLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLPGNIFANVNGLMAIQLQN 398
Query: 352 NQIAVLP----DHFGQLSRVGLWKIKDNP 376
NQ+ LP DH G+L + L+ DNP
Sbjct: 399 NQLENLPLGIFDHLGKLCELRLY---DNP 424
Score = 104 bits (259), Expect = 5e-22
Identities = 110/352 (31%), Positives = 165/352 (46%), Gaps = 19/352 (5%)
Query: 40 CPGAGADALESPASPQLVLPANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRF 99
C GA A+ +P LP N ++ LN L E P SAL +LR+ +N
Sbjct: 39 CTGARIVAVPTP------LPWNAMSLQILNTHITELNESPFLNISALIALRI---EKNEL 89
Query: 100 ARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPAL-PAQLGALA 158
+R+ P L L +++N+L L + L L L LS NQL + PA +
Sbjct: 90 SRITPGAFRNLGSLRYLSLANNKLQVLPIGLFQGLDSLESLLLSSNQLLQIQPAHFSQCS 149
Query: 159 HLEELDVSFNRLAHLPD-SLSCLSRLRTLDVDHNQLTAF-PRQLLQLVALEELDVSSNRL 216
+L+EL + N L ++PD + L L L++ N LT PR L L+ L + NRL
Sbjct: 150 NLKELQLHGNHLEYIPDGAFDHLVGLTKLNLGKNSLTHISPRVFQHLGNLQVLRLYENRL 209
Query: 217 RGLP-EDISALRALKILWLSGAELGTLPAG-FCELASLESLMLDNNGLQALPAQ-FSCLQ 273
+P L L+ L L ++G L G F +L+ L L NN + LP F L
Sbjct: 210 TDIPMGTFDGLVNLQELALQQNQIGLLSPGLFHNNHNLQRLYLSNNHISQLPPSIFMQLP 269
Query: 274 RLKMLNLSSNLFEEFPAALL-PLAGLEELYLSRNQLTSVP-SLISGLGRLLTLWLDNNRI 331
+L L L N +E + P+ L EL+L N ++S+P ++ S L +L L L N+I
Sbjct: 270 QLNRLTLFGNSLKELSLGIFGPMPNLRELWLYDNHISSLPDNVFSNLRQLQVLILSRNQI 329
Query: 332 RYL-PDSIVELTGLEELVLQGNQIAVLPDH-FGQLSRVGLWKIKDNPLIQPP 381
++ P + LT L EL L N + L + F L+ + +++N L Q P
Sbjct: 330 SFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQNNRLRQLP 381
Score = 43.9 bits (102), Expect = 8e-04
Identities = 31/104 (29%), Positives = 48/104 (46%), Gaps = 2/104 (1%)
Query: 60 ANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVS 119
+NL ++ L L N + + G + L LR L L N L V + +L + +
Sbjct: 314 SNLRQLQVLILSRNQISFISPGAFNGLTELRELSLHTNALQDLDGNVFRMLANLQNISLQ 373
Query: 120 HNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEEL 163
+NRL L + + + L + L +NQL LP LG HL +L
Sbjct: 374 NNRLRQLPGNIFANVNGLMAIQLQNNQLENLP--LGIFDHLGKL 415
>gi|122937470 carboxypeptidase N, polypeptide 2, 83kD [Homo sapiens]
Length = 545
Score = 108 bits (269), Expect = 3e-23
Identities = 99/300 (33%), Positives = 137/300 (45%), Gaps = 29/300 (9%)
Query: 60 ANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVS 119
+NL + L L N LE +PEGL L +L L L+ N+ LP + + HL L+++
Sbjct: 118 SNLTSLGKLTLNFNMLEALPEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLA 177
Query: 120 HNRLTALGAEVVSALRELRKLNLSHNQLPALP-AQLGALAHLEELDVSFNRLAHLPDSLS 178
N L L E+ L L+ L LS+N L LP G L L+EL + N ++ LP
Sbjct: 178 QNLLAQLPEELFHPLTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELP---- 233
Query: 179 CLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDI-SALRALKILWLSGA 237
P+ QL LE L + N + LP I ++L L L L
Sbjct: 234 ------------------PQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLTFLSLQWN 275
Query: 238 ELGTLPAG-FCELASLESLMLDNNGLQAL-PAQFSCLQRLKMLNLSSNLFEEFPAALL-P 294
L LPAG F L L L +N L+ + F+ L L+ L LS N PA +
Sbjct: 276 MLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHLPAGIFRD 335
Query: 295 LAGLEELYLSRNQLTSV-PSLISGLGRLLTLWLDNNRIRYLPDSIVELT-GLEELVLQGN 352
L L +LYL N LT++ P+L L +L L L N++ LP+ I + L L L GN
Sbjct: 336 LEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPEGIFDTNYNLFNLALHGN 395
Score = 100 bits (248), Expect = 9e-21
Identities = 96/290 (33%), Positives = 146/290 (50%), Gaps = 10/290 (3%)
Query: 79 PEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELR 138
P+ G L L L + + F L + L +L ++ N L AL + L L
Sbjct: 90 PDAFGG-LPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEALPEGLFQHLAALE 148
Query: 139 KLNLSHNQLPALPAQL-GALAHLEELDVSFNRLAHLPDSL-SCLSRLRTLDVDHNQLTAF 196
L+L NQL ALP +L L HL+ L+++ N LA LP+ L L+ L+TL + +N L+
Sbjct: 149 SLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEELFHPLTSLQTLKLSNNALSGL 208
Query: 197 PRQLL-QLVALEELDVSSNRLRGLPEDI-SALRALKILWLSGAELGTLPAG-FCELASLE 253
P+ + +L +L+EL + SN + LP + S L L+ LWL + LP F L +L
Sbjct: 209 PQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRNAITHLPLSIFASLGNLT 268
Query: 254 SLMLDNNGLQALPAQ-FSCLQRLKMLNLSSNLFEEFPAALLP-LAGLEELYLSRNQLTSV 311
L L N L+ LPA F+ L L+L+ N E L+ L L LS N +T +
Sbjct: 269 FLSLQWNMLRVLPAGLFAHTPCLVGLSLTHNQLETVAEGTFAHLSNLRSLMLSYNAITHL 328
Query: 312 PS-LISGLGRLLTLWLDNNRIRYLPDSIVE-LTGLEELVLQGNQIAVLPD 359
P+ + L L+ L+L +N + L ++ + L+ LE L L NQ+ LP+
Sbjct: 329 PAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLSKNQLTTLPE 378
Score = 82.4 bits (202), Expect = 2e-15
Identities = 78/233 (33%), Positives = 117/233 (50%), Gaps = 14/233 (6%)
Query: 62 LGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHN 121
L ++ L L NN L +P+G+ LGSL+ L L N + LPP V L L + N
Sbjct: 192 LTSLQTLKLSNNALSGLPQGVFGKLGSLQELFLDSNNISELPPQVFSQLFCLERLWLQRN 251
Query: 122 RLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAH---LEELDVSFNRLAHLPD-SL 177
+T L + ++L L L+L N L LPA G AH L L ++ N+L + + +
Sbjct: 252 AITHLPLSIFASLGNLTFLSLQWNMLRVLPA--GLFAHTPCLVGLSLTHNQLETVAEGTF 309
Query: 178 SCLSRLRTLDVDHNQLTAFPRQLLQ-LVALEELDVSSNRLRGL-PEDISALRALKILWLS 235
+ LS LR+L + +N +T P + + L L +L + SN L L P L L++L LS
Sbjct: 310 AHLSNLRSLMLSYNAITHLPAGIFRDLEELVKLYLGSNNLTALHPALFQNLSKLELLSLS 369
Query: 236 GAELGTLPAG-FCELASLESLMLDNNGLQA---LPAQFSCLQRL--KMLNLSS 282
+L TLP G F +L +L L N Q L F+ LQ+ ++LN+ +
Sbjct: 370 KNQLTTLPEGIFDTNYNLFNLALHGNPWQCDCHLAYLFNWLQQYTDRLLNIQT 422
Score = 41.6 bits (96), Expect = 0.004
Identities = 35/112 (31%), Positives = 58/112 (51%), Gaps = 3/112 (2%)
Query: 276 KMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPS-LISGLGRLLTLWLDNNRIRYL 334
K++ L++ L + P A L LE+L ++ + ++ + + S L L L L+ N + L
Sbjct: 77 KVVFLNTQLCQFRPDAFGGLPRLEDLEVTGSSFLNLSTNIFSNLTSLGKLTLNFNMLEAL 136
Query: 335 PDSIVE-LTGLEELVLQGNQIAVLPDH-FGQLSRVGLWKIKDNPLIQPPYEV 384
P+ + + L LE L LQGNQ+ LP F L+ + + N L Q P E+
Sbjct: 137 PEGLFQHLAALESLHLQGNQLQALPRRLFQPLTHLKTLNLAQNLLAQLPEEL 188
>gi|6912638 ras suppressor protein 1 isoform 1 [Homo sapiens]
Length = 277
Score = 107 bits (267), Expect = 6e-23
Identities = 83/241 (34%), Positives = 118/241 (48%), Gaps = 30/241 (12%)
Query: 162 ELDVSFNRLAHLPD--SLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGL 219
E+D+S ++++ D L LS + L + HN+LT P + +L LE L+ +N++ L
Sbjct: 19 EVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEEL 78
Query: 220 PEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNGL--QALPAQFSCLQRLKM 277
P IS+L+ LK L L L TLP GF L +LE L L N L +LP F L L+
Sbjct: 79 PTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRA 138
Query: 278 LNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDS 337
L LS N FE P + L L+ L L N L S LP
Sbjct: 139 LYLSDNDFEILPPDIGKLTKLQILSLRDNDLIS-----------------------LPKE 175
Query: 338 IVELTGLEELVLQGNQIAVLPDHFGQLSRVG---LWKIKDNPLIQPPYEVCMKGIPYIAA 394
I ELT L+EL +QGN++ VLP G L G ++K ++NP + P + G+ ++
Sbjct: 176 IGELTQLKELHIQGNRLTVLPPELGNLDLTGQKQVFKAENNPWVTPIADQFQLGVSHVFE 235
Query: 395 Y 395
Y
Sbjct: 236 Y 236
Score = 90.5 bits (223), Expect = 7e-18
Identities = 63/197 (31%), Positives = 102/197 (51%), Gaps = 5/197 (2%)
Query: 115 ELDVSHNRLT-ALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHL 173
E+D+S ++ L + L + +L LSHN+L +P + L +LE L+ N++ L
Sbjct: 19 EVDMSDRGISNMLDVNGLFTLSHITQLVLSHNKLTMVPPNIAELKNLEVLNFFNNQIEEL 78
Query: 174 PDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRL--RGLPEDISALRALKI 231
P +S L +L+ L++ N+L PR L ALE LD++ N L LP + L L+
Sbjct: 79 PTQISSLQKLKHLNLGMNRLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRA 138
Query: 232 LWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAA 291
L+LS + LP +L L+ L L +N L +LP + L +LK L++ N P
Sbjct: 139 LYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPPE 198
Query: 292 L--LPLAGLEELYLSRN 306
L L L G ++++ + N
Sbjct: 199 LGNLDLTGQKQVFKAEN 215
Score = 84.3 bits (207), Expect = 5e-16
Identities = 59/170 (34%), Positives = 92/170 (54%), Gaps = 7/170 (4%)
Query: 86 LGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVSALRELRKLNLSHN 145
L + LVL N+ +PP +AEL +L L+ +N++ L + +S+L++L+ LNL N
Sbjct: 39 LSHITQLVLSHNKLTMVPPNIAEL-KNLEVLNFFNNQIEELPTQ-ISSLQKLKHLNLGMN 96
Query: 146 QLPALPAQLGALAHLEELDVSFNRLAH--LPDSLSCLSRLRTLDVDHNQLTAFPRQLLQL 203
+L LP G+L LE LD+++N L+ LP + L+ LR L + N P + +L
Sbjct: 97 RLNTLPRGFGSLPALEVLDLTYNNLSENSLPGNFFYLTTLRALYLSDNDFEILPPDIGKL 156
Query: 204 VALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLE 253
L+ L + N L LP++I L LK L + G L LP EL +L+
Sbjct: 157 TKLQILSLRDNDLISLPKEIGELTQLKELHIQGNRLTVLPP---ELGNLD 203
Score = 52.8 bits (125), Expect = 2e-06
Identities = 45/141 (31%), Positives = 64/141 (45%), Gaps = 24/141 (17%)
Query: 60 ANLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVS 119
++L ++ LNLG N L +P G GS L +L VL L N +L+E +
Sbjct: 83 SSLQKLKHLNLGMNRLNTLPRGFGS-LPALEVLDLTYN--------------NLSENSLP 127
Query: 120 HNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSC 179
N L LR L LS N LP +G L L+ L + N L LP +
Sbjct: 128 GN---------FFYLTTLRALYLSDNDFEILPPDIGKLTKLQILSLRDNDLISLPKEIGE 178
Query: 180 LSRLRTLDVDHNQLTAFPRQL 200
L++L+ L + N+LT P +L
Sbjct: 179 LTQLKELHIQGNRLTVLPPEL 199
>gi|40217803 leucine rich repeat containing 8 family, member E [Homo
sapiens]
Length = 796
Score = 107 bits (267), Expect = 6e-23
Identities = 94/282 (33%), Positives = 133/282 (47%), Gaps = 21/282 (7%)
Query: 14 LWRDAALRARKLRSNLRQLTLTA-AGACPGAGADALESPASPQLVLPANLGDIEALNLGN 72
L R A L + + L+ L+L + AG P + D G ++ L+L N
Sbjct: 522 LARAATLESLRELKQLKVLSLRSNAGKVPASVTDVA--------------GHLQRLSLHN 567
Query: 73 NGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTALGAEVVS 132
+G V L +LR L L R+P AV LG L ELD+ N L ++ E++S
Sbjct: 568 DGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGA-LQELDLKDNHLRSI-EEILS 625
Query: 133 A--LRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRTLDVDH 190
R+L L L HNQ+ +P + L LE+L +S+N+L LP L S LR LDV H
Sbjct: 626 FQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSH 685
Query: 191 NQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELA 250
N L + P ++ L L+ L +S N L LPE++ R L+ L L +L L L
Sbjct: 686 NGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALR 745
Query: 251 SLESLMLDNNGLQALPAQFSCLQRLKMLNL--SSNLFEEFPA 290
+L L L N L+ALP + LK L L++ PA
Sbjct: 746 ALSRLELKGNRLEALPEELGNCGGLKKAGLLVEDTLYQGLPA 787
Score = 100 bits (248), Expect = 9e-21
Identities = 86/292 (29%), Positives = 132/292 (45%), Gaps = 40/292 (13%)
Query: 71 GNNGLEEV------PEGLGSA--------LGSLRVLVLRRNRFARLPPAVAELGHHLTEL 116
G GLEE+ P+ L A L L+VL LR N ++P +V ++ HL L
Sbjct: 505 GLRGLEELHLEGLFPQELARAATLESLRELKQLKVLSLRSNA-GKVPASVTDVAGHLQRL 563
Query: 117 DVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDS 176
+ ++ + + L LR+L L L +P + +L L+ELD+ N L + +
Sbjct: 564 SLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEI 623
Query: 177 LSC--LSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWL 234
LS +L TL + HNQ+ P + +L +LE+L +S N+L LP + L++L +
Sbjct: 624 LSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDV 683
Query: 235 SGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLP 294
S +NGL +LP + LQ L+ L LS N E P L
Sbjct: 684 S-----------------------HNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFF 720
Query: 295 LAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEE 346
L L L NQL+ + + L L L L NR+ LP+ + GL++
Sbjct: 721 CRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEELGNCGGLKK 772
Score = 97.4 bits (241), Expect = 6e-20
Identities = 82/252 (32%), Positives = 128/252 (50%), Gaps = 11/252 (4%)
Query: 128 AEVVSALRELRKLNLSHNQLPA--LPAQLGALA-HLEELDVSFN--RLAHLPDSLSCLSR 182
A + +LREL++L + + A +PA + +A HL+ L + + RL L +SL L+
Sbjct: 525 AATLESLRELKQLKVLSLRSNAGKVPASVTDVAGHLQRLSLHNDGARLVAL-NSLKKLAA 583
Query: 183 LRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISA--LRALKILWLSGAELG 240
LR L++ L P + L AL+ELD+ N LR + E +S R L L L ++
Sbjct: 584 LRELELVACGLERIPHAVFSLGALQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIA 643
Query: 241 TLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEE 300
+P +L SLE L L N L+ LP+Q L++L++S N P + L L+
Sbjct: 644 YVPEHVRKLRSLEQLYLSYNKLETLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQH 703
Query: 301 LYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDH 360
L LS N L ++P + +L TL L +N++ L + L L L L+GN++ LP+
Sbjct: 704 LALSYNALEALPEELFFCRKLRTLLLGDNQLSQLSPHVGALRALSRLELKGNRLEALPEE 763
Query: 361 FGQ---LSRVGL 369
G L + GL
Sbjct: 764 LGNCGGLKKAGL 775
Score = 83.6 bits (205), Expect = 9e-16
Identities = 103/395 (26%), Positives = 164/395 (41%), Gaps = 68/395 (17%)
Query: 111 HHLTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRL 170
H + + D +++ A+ VS R L++LNL+H P Q L+++ L
Sbjct: 368 HLIDQYDSLYSKRFAVFLSEVSESR-LKQLNLNHEWTPEKLRQKLQRNAAGRLELALCML 426
Query: 171 AHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELD-------------------- 210
LPD++ LS + +L ++ FP L QLV L+EL
Sbjct: 427 PGLPDTVFELSEVESLRLEAICDITFPPGLSQLVHLQELSLLHSPARLPFSLQVFLRDHL 486
Query: 211 ----VSSNRLRGLPEDISALRALKILWLSG---------------------------AEL 239
V LR +P + LR L+ L L G +
Sbjct: 487 KVMRVKCEELREVPLWVFGLRGLEELHLEGLFPQELARAATLESLRELKQLKVLSLRSNA 546
Query: 240 GTLPAGFCELAS-LESLMLDNNGLQALPA-QFSCLQRLKMLNLSSNLFEEFPAALLPLAG 297
G +PA ++A L+ L L N+G + + L L+ L L + E P A+ L
Sbjct: 547 GKVPASVTDVAGHLQRLSLHNDGARLVALNSLKKLAALRELELVACGLERIPHAVFSLGA 606
Query: 298 LEELYLSRNQLTSVPSLIS--GLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIA 355
L+EL L N L S+ ++S +L+TL L +N+I Y+P+ + +L LE+L L N++
Sbjct: 607 LQELDLKDNHLRSIEEILSFQHCRKLVTLRLWHNQIAYVPEHVRKLRSLEQLYLSYNKLE 666
Query: 356 VLPDHFGQLSRVGLWKIKDNPLIQPPYEV-CMKGIPYIAAYQK--ELAHSQPAVQPRLKL 412
LP G S + L + N L P EV ++ + ++A E + +L+
Sbjct: 667 TLPSQLGLCSGLRLLDVSHNGLHSLPPEVGLLQNLQHLALSYNALEALPEELFFCRKLRT 726
Query: 413 LLMG---------HKAAGKTLLRHCLTEERVEGCP 438
LL+G H A + L R L R+E P
Sbjct: 727 LLLGDNQLSQLSPHVGALRALSRLELKGNRLEALP 761
>gi|30181233 leucine-rich repeats and calponin homology (CH) domain
containing 4 [Homo sapiens]
Length = 683
Score = 107 bits (266), Expect = 8e-23
Identities = 83/231 (35%), Positives = 115/231 (49%), Gaps = 6/231 (2%)
Query: 68 LNLGNNGLEEVPEGLGSA--LGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHNRLTA 125
LNL N L+ P G + L + L RNRF +P A +L L L + HN L
Sbjct: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVS-LEGLSLYHNCLRC 105
Query: 126 LGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLPDSLSCLSRLRT 185
L + L L LNLS NQL LP + L L L VS N+L LP + L LR
Sbjct: 106 LNP-ALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALPPDIGTLGSLRQ 163
Query: 186 LDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAG 245
LDV N+L + P +L L +L +L+V N+L LPE++ L ++ L S + +P
Sbjct: 164 LDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLVR-LDFSCNRVSRIPVS 222
Query: 246 FCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLA 296
FC L L+ ++LD+N LQ+ PAQ +L + S + +AL LA
Sbjct: 223 FCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFKYLSTEAGQRGSALGDLA 273
Score = 91.7 bits (226), Expect = 3e-18
Identities = 71/208 (34%), Positives = 104/208 (50%), Gaps = 4/208 (1%)
Query: 116 LDVSHNRLTAL--GAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHL 173
L++S+ RL GA L ++ + +LS N+ P +P L LE L + N L L
Sbjct: 47 LNLSNRRLKHFPRGAARSYDLSDITQADLSRNRFPEVPEAACQLVSLEGLSLYHNCLRCL 106
Query: 174 PDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILW 233
+L L+ L L++ NQL+ P + QL L L VS+N+L LP DI L +L+ L
Sbjct: 107 NPALGNLTALTYLNLSRNQLSLLPPYICQL-PLRVLIVSNNKLGALPPDIGTLGSLRQLD 165
Query: 234 LSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALL 293
+S EL +LP+ C L+SL L + N L LP + L L L+ S N P +
Sbjct: 166 VSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLP-LVRLDFSCNRVSRIPVSFC 224
Query: 294 PLAGLEELYLSRNQLTSVPSLISGLGRL 321
L L+ + L N L S P+ + G+L
Sbjct: 225 RLRHLQVILLDSNPLQSPPAQVCLKGKL 252
Score = 84.7 bits (208), Expect = 4e-16
Identities = 69/225 (30%), Positives = 104/225 (46%), Gaps = 30/225 (13%)
Query: 198 RQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGT-----LPAGFCELASL 252
R L + VA L++S+ RL+ P A R+ + ++ A+L +P C+L SL
Sbjct: 36 RALEEAVATGTLNLSNRRLKHFPR--GAARSYDLSDITQADLSRNRFPEVPEAACQLVSL 93
Query: 253 ESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVP 312
E L L +N L+ L L L LNLS N P + L L L +S N+L ++P
Sbjct: 94 EGLSLYHNCLRCLNPALGNLTALTYLNLSRNQLSLLPPYICQLP-LRVLIVSNNKLGALP 152
Query: 313 SLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGL--- 369
I LG L L + +N ++ LP + L+ L +L ++ NQ++ LP+ G L V L
Sbjct: 153 PDIGTLGSLRQLDVSSNELQSLPSELCGLSSLRDLNVRRNQLSTLPEELGDLPLVRLDFS 212
Query: 370 -------------------WKIKDNPLIQPPYEVCMKGIPYIAAY 395
+ NPL PP +VC+KG +I Y
Sbjct: 213 CNRVSRIPVSFCRLRHLQVILLDSNPLQSPPAQVCLKGKLHIFKY 257
>gi|21389431 leucine rich repeat containing 39 [Homo sapiens]
Length = 335
Score = 106 bits (265), Expect = 1e-22
Identities = 74/240 (30%), Positives = 116/240 (48%), Gaps = 28/240 (11%)
Query: 62 LGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSHN 121
L ++ L GL ++PE +G +L VL L RN + +PP +
Sbjct: 82 LNQLQEWQLHRTGLLKIPEFIGR-FQNLIVLDLSRNTISEIPPGIG-------------- 126
Query: 122 RLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNR-LAHLPDSLSCL 180
L L++L LS+N++ +P +L A LE+L+++ NR + LP LS L
Sbjct: 127 -----------LLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNL 175
Query: 181 SRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELG 240
+L LD+ N T P +L + ALE LD+ SN+L LP+ I ++ L LWL E+
Sbjct: 176 LKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEIT 235
Query: 241 TLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEE 300
LP + +L +L+L NN LQ +P + L+ +N N + +L P G +E
Sbjct: 236 CLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLRFVNFRDNPL-KLKVSLPPSEGTDE 294
Score = 99.0 bits (245), Expect = 2e-20
Identities = 69/206 (33%), Positives = 102/206 (49%), Gaps = 1/206 (0%)
Query: 173 LPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKIL 232
LP SL L++L+ + L P + + L LD+S N + +P I L L+ L
Sbjct: 75 LPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPGIGLLTRLQEL 134
Query: 233 WLSGAELGTLPAGFCELASLESLMLD-NNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAA 291
LS ++ T+P ASLE L L N + LP + S L +L L+LS N F P A
Sbjct: 135 ILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLA 194
Query: 292 LLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQG 351
+L + LE L + N+L +P I + L TLWL N I LP +I + L LVL
Sbjct: 195 VLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSN 254
Query: 352 NQIAVLPDHFGQLSRVGLWKIKDNPL 377
N++ +P +++ + +DNPL
Sbjct: 255 NKLQDIPVCMEEMANLRFVNFRDNPL 280
Score = 84.7 bits (208), Expect = 4e-16
Identities = 60/203 (29%), Positives = 96/203 (47%), Gaps = 3/203 (1%)
Query: 186 LDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAG 245
L ++ + P LL+L L+E + L +PE I + L +L LS + +P G
Sbjct: 65 LKIEKEEWKTLPSSLLKLNQLQEWQLHRTGLLKIPEFIGRFQNLIVLDLSRNTISEIPPG 124
Query: 246 FCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNL-FEEFPAALLPLAGLEELYLS 304
L L+ L+L N ++ +P + S L+ L L+ N + P L L L L LS
Sbjct: 125 IGLLTRLQELILSYNKIKTVPKELSNCASLEKLELAVNRDICDLPQELSNLLKLTHLDLS 184
Query: 305 RNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQL 364
N T++P + + L L + +N++ LPD+I + L L LQ N+I LP +
Sbjct: 185 MNDFTTIPLAVLNMPALEWLDMGSNKLEQLPDTIERMQNLHTLWLQRNEITCLPQTISNM 244
Query: 365 SRVGLWKIKDNPLIQPPYEVCMK 387
+G + +N L P VCM+
Sbjct: 245 KNLGTLVLSNNKLQDIP--VCME 265
Score = 73.9 bits (180), Expect = 7e-13
Identities = 52/178 (29%), Positives = 95/178 (53%), Gaps = 8/178 (4%)
Query: 56 LVLPANLGDIE---ALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHH 112
L +P +G + L+L N + E+P G+G L L+ L+L N+ +P ++
Sbjct: 96 LKIPEFIGRFQNLIVLDLSRNTISEIPPGIG-LLTRLQELILSYNKIKTVPKELSNCA-S 153
Query: 113 LTELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAH 172
L +L+++ NR + +S L +L L+LS N +P + + LE LD+ N+L
Sbjct: 154 LEKLELAVNRDICDLPQELSNLLKLTHLDLSMNDFTTIPLAVLNMPALEWLDMGSNKLEQ 213
Query: 173 LPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLP---EDISALR 227
LPD++ + L TL + N++T P+ + + L L +S+N+L+ +P E+++ LR
Sbjct: 214 LPDTIERMQNLHTLWLQRNEITCLPQTISNMKNLGTLVLSNNKLQDIPVCMEEMANLR 271
Score = 36.2 bits (82), Expect = 0.17
Identities = 25/87 (28%), Positives = 48/87 (55%), Gaps = 3/87 (3%)
Query: 61 NLGDIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLTELDVSH 120
N+ +E L++G+N LE++P+ + + +L L L+RN LP ++ + +L L +S+
Sbjct: 197 NMPALEWLDMGSNKLEQLPDTI-ERMQNLHTLWLQRNEITCLPQTISNM-KNLGTLVLSN 254
Query: 121 NRLTALGAEVVSALRELRKLNLSHNQL 147
N+L + + + LR +N N L
Sbjct: 255 NKLQDIPV-CMEEMANLRFVNFRDNPL 280
>gi|197333706 leucine rich repeat containing 8 family, member D
[Homo sapiens]
Length = 858
Score = 103 bits (258), Expect = 7e-22
Identities = 99/356 (27%), Positives = 173/356 (48%), Gaps = 23/356 (6%)
Query: 46 DALESPASPQLVLPANLG---DIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARL 102
D L+ P+ +PA + +++ L+L + + LR L ++ A +
Sbjct: 493 DVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEI 552
Query: 103 PPAVAELG-----HHLTELDVSHNRLTALGAEVVSALRELRKLNLSH--NQLPALPAQLG 155
P V L + + L+ +N++ L +LRELR L + H + L +P+ +
Sbjct: 553 PAWVYLLKNLRELYLIGNLNSENNKMIGL-----ESLRELRHLKILHVKSNLTKVPSNIT 607
Query: 156 ALA-HLEELDVSFNRLAHLP-DSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSS 213
+A HL +L + + L +SL + + L++ + +L P + L L+ELD+ S
Sbjct: 608 DVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKS 667
Query: 214 NRLRGLPEDISA--LRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSC 271
N +R + E IS L+ L L L ++ T+P + +LESL NN L++LP
Sbjct: 668 NNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFS 727
Query: 272 LQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRI 331
LQ+L+ L++S N P + L L+ L+++ N++ +P + +L TL L N I
Sbjct: 728 LQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCI 787
Query: 332 RYLPDSIVELTGLEELVLQGNQIAVLPDHFGQ---LSRVGLWKIKDNPLIQPPYEV 384
LP+ + +L+ L +L L+GN + LP GQ L + GL ++D+ P EV
Sbjct: 788 TSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGL-VVEDHLFDTLPLEV 842
Score = 87.8 bits (216), Expect = 5e-17
Identities = 76/261 (29%), Positives = 130/261 (49%), Gaps = 15/261 (5%)
Query: 58 LPANLGDIEA----LNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHL 113
+P+N+ D+ L + N+G + + + ++ L L+ R+P A+ L + L
Sbjct: 602 VPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSN-L 660
Query: 114 TELDVSHNRLTALGAEVVSA--LRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLA 171
ELD+ N + + E++S L+ L L L HN++ +P + + +LE L S N+L
Sbjct: 661 QELDLKSNNIRTI-EEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLE 719
Query: 172 HLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKI 231
LP ++ L +LR LDV +N ++ P ++ L L+ L ++ N++ LP+ + L+
Sbjct: 720 SLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRT 779
Query: 232 LWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAA 291
L L + +LP +L+ L L L N L LPAQ L + +ML S + E+
Sbjct: 780 LNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQ---LGQCRMLKKSGLVVEDHLFD 836
Query: 292 LLPLAGLEELYLSRNQLTSVP 312
LPL E L NQ ++P
Sbjct: 837 TLPLEVKEAL----NQDINIP 853
Score = 47.8 bits (112), Expect = 6e-05
Identities = 65/295 (22%), Positives = 115/295 (38%), Gaps = 56/295 (18%)
Query: 143 SHNQLPALPAQLGALAHL-EELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLL 201
S + +P + L H+ ++ D +++ + S ++LR + ++H RQ +
Sbjct: 405 SFSDIPDVKNDFAFLLHMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHI 464
Query: 202 QLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNG 261
A ++ ++ L G+P+ + L L +L L +PA ++ +L+ L L +
Sbjct: 465 SRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCP 524
Query: 262 LQALPAQFSCLQ-RLKMLNLSSNLFEEFPAALLPLAGLEELYLSRN-------------- 306
+ FS L+ L+ L++ E PA + L L ELYL N
Sbjct: 525 AKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESL 584
Query: 307 -------------QLTSVPSLISGLGRLLT-------------------------LWLDN 328
LT VPS I+ + LT L L N
Sbjct: 585 RELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQN 644
Query: 329 NRIRYLPDSIVELTGLEELVLQGNQIAVLPD--HFGQLSRVGLWKIKDNPLIQPP 381
+ +P +I L+ L+EL L+ N I + + F L R+ K+ N ++ P
Sbjct: 645 CELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIP 699
>gi|34222199 leucine rich repeat containing 8 family, member D [Homo
sapiens]
Length = 858
Score = 103 bits (258), Expect = 7e-22
Identities = 99/356 (27%), Positives = 173/356 (48%), Gaps = 23/356 (6%)
Query: 46 DALESPASPQLVLPANLG---DIEALNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARL 102
D L+ P+ +PA + +++ L+L + + LR L ++ A +
Sbjct: 493 DVLKLELIPEAKIPAKISQMTNLQELHLCHCPAKVEQTAFSFLRDHLRCLHVKFTDVAEI 552
Query: 103 PPAVAELG-----HHLTELDVSHNRLTALGAEVVSALRELRKLNLSH--NQLPALPAQLG 155
P V L + + L+ +N++ L +LRELR L + H + L +P+ +
Sbjct: 553 PAWVYLLKNLRELYLIGNLNSENNKMIGL-----ESLRELRHLKILHVKSNLTKVPSNIT 607
Query: 156 ALA-HLEELDVSFNRLAHLP-DSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSS 213
+A HL +L + + L +SL + + L++ + +L P + L L+ELD+ S
Sbjct: 608 DVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSNLQELDLKS 667
Query: 214 NRLRGLPEDISA--LRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSC 271
N +R + E IS L+ L L L ++ T+P + +LESL NN L++LP
Sbjct: 668 NNIRTIEEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLESLPVAVFS 727
Query: 272 LQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRI 331
LQ+L+ L++S N P + L L+ L+++ N++ +P + +L TL L N I
Sbjct: 728 LQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRTLNLGQNCI 787
Query: 332 RYLPDSIVELTGLEELVLQGNQIAVLPDHFGQ---LSRVGLWKIKDNPLIQPPYEV 384
LP+ + +L+ L +L L+GN + LP GQ L + GL ++D+ P EV
Sbjct: 788 TSLPEKVGQLSQLTQLELKGNCLDRLPAQLGQCRMLKKSGL-VVEDHLFDTLPLEV 842
Score = 87.8 bits (216), Expect = 5e-17
Identities = 76/261 (29%), Positives = 130/261 (49%), Gaps = 15/261 (5%)
Query: 58 LPANLGDIEA----LNLGNNGLEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHL 113
+P+N+ D+ L + N+G + + + ++ L L+ R+P A+ L + L
Sbjct: 602 VPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQNCELERIPHAIFSLSN-L 660
Query: 114 TELDVSHNRLTALGAEVVSA--LRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLA 171
ELD+ N + + E++S L+ L L L HN++ +P + + +LE L S N+L
Sbjct: 661 QELDLKSNNIRTI-EEIISFQHLKRLTCLKLWHNKIVTIPPSITHVKNLESLYFSNNKLE 719
Query: 172 HLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKI 231
LP ++ L +LR LDV +N ++ P ++ L L+ L ++ N++ LP+ + L+
Sbjct: 720 SLPVAVFSLQKLRCLDVSYNNISMIPIEIGLLQNLQHLHITGNKVDILPKQLFKCIKLRT 779
Query: 232 LWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAA 291
L L + +LP +L+ L L L N L LPAQ L + +ML S + E+
Sbjct: 780 LNLGQNCITSLPEKVGQLSQLTQLELKGNCLDRLPAQ---LGQCRMLKKSGLVVEDHLFD 836
Query: 292 LLPLAGLEELYLSRNQLTSVP 312
LPL E L NQ ++P
Sbjct: 837 TLPLEVKEAL----NQDINIP 853
Score = 47.8 bits (112), Expect = 6e-05
Identities = 65/295 (22%), Positives = 115/295 (38%), Gaps = 56/295 (18%)
Query: 143 SHNQLPALPAQLGALAHL-EELDVSFNRLAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLL 201
S + +P + L H+ ++ D +++ + S ++LR + ++H RQ +
Sbjct: 405 SFSDIPDVKNDFAFLLHMVDQYDQLYSKRFGVFLSEVSENKLREISLNHEWTFEKLRQHI 464
Query: 202 QLVALEELDVSSNRLRGLPEDISALRALKILWLSGAELGTLPAGFCELASLESLMLDNNG 261
A ++ ++ L G+P+ + L L +L L +PA ++ +L+ L L +
Sbjct: 465 SRNAQDKQELHLFMLSGVPDAVFDLTDLDVLKLELIPEAKIPAKISQMTNLQELHLCHCP 524
Query: 262 LQALPAQFSCLQ-RLKMLNLSSNLFEEFPAALLPLAGLEELYLSRN-------------- 306
+ FS L+ L+ L++ E PA + L L ELYL N
Sbjct: 525 AKVEQTAFSFLRDHLRCLHVKFTDVAEIPAWVYLLKNLRELYLIGNLNSENNKMIGLESL 584
Query: 307 -------------QLTSVPSLISGLGRLLT-------------------------LWLDN 328
LT VPS I+ + LT L L N
Sbjct: 585 RELRHLKILHVKSNLTKVPSNITDVAPHLTKLVIHNDGTKLLVLNSLKKMMNVAELELQN 644
Query: 329 NRIRYLPDSIVELTGLEELVLQGNQIAVLPD--HFGQLSRVGLWKIKDNPLIQPP 381
+ +P +I L+ L+EL L+ N I + + F L R+ K+ N ++ P
Sbjct: 645 CELERIPHAIFSLSNLQELDLKSNNIRTIEEIISFQHLKRLTCLKLWHNKIVTIP 699
>gi|61742786 leucine rich repeat and death domain containing protein
isoform 3 [Homo sapiens]
Length = 893
Score = 102 bits (254), Expect = 2e-21
Identities = 82/202 (40%), Positives = 101/202 (50%), Gaps = 12/202 (5%)
Query: 123 LTALGAEVVSALRELRKLNLSHNQ------------LPALPAQLGALAHLEELDVSFNRL 170
L A A++ +L LR L L Q L LPA L LAHL LD+SFN L
Sbjct: 78 LEATLAQLPQSLSCLRSLVLKGGQRRDTLGACLRGALTNLPAGLSGLAHLAHLDLSFNSL 137
Query: 171 AHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALK 230
LP + + L L + HN L+ P L L AL L V+ NRL+ LP + AL L+
Sbjct: 138 ETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQ 197
Query: 231 ILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPA 290
L LS L TLP L SL L L +N LQ+LPA + L+ L++L L SNL PA
Sbjct: 198 RLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPA 257
Query: 291 ALLPLAGLEELYLSRNQLTSVP 312
L L L L L NQL +P
Sbjct: 258 DLARLPLLTRLDLRDNQLRDLP 279
Score = 97.8 bits (242), Expect = 5e-20
Identities = 70/185 (37%), Positives = 97/185 (52%), Gaps = 3/185 (1%)
Query: 170 LAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRAL 229
L +LP LS L+ L LD+ N L P +LQ+ L L +S N L LPE + AL AL
Sbjct: 114 LTNLPAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPAL 173
Query: 230 KILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFP 289
L ++ L TLP L++L+ L L N L LP + L L LNL+SN + P
Sbjct: 174 TFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLP 233
Query: 290 AALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVL 349
A+L L L L L N L SVP+ ++ L L L L +N++R LP +++ + L
Sbjct: 234 ASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELLDAPFVR---L 290
Query: 350 QGNQI 354
QGN +
Sbjct: 291 QGNPL 295
Score = 97.4 bits (241), Expect = 6e-20
Identities = 80/239 (33%), Positives = 110/239 (46%), Gaps = 24/239 (10%)
Query: 170 LAHLPDSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRG----LPEDISA 225
LA LP SLSCL + L L + D LRG LP +S
Sbjct: 82 LAQLPQSLSCL------------------RSLVLKGGQRRDTLGACLRGALTNLPAGLSG 123
Query: 226 LRALKILWLSGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLF 285
L L L LS L TLPA ++ L +L+L +N L LP L L L ++ N
Sbjct: 124 LAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELPEALGALPALTFLTVTHNRL 183
Query: 286 EEFPAALLPLAGLEELYLSRNQLTSVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLE 345
+ P AL L+ L+ L LS+N L ++P I GLG LL L L +NR++ LP S+ L L
Sbjct: 184 QTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNLASNRLQSLPASLAGLRSLR 243
Query: 346 ELVLQGNQIAVLPDHFGQLSRVGLWKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQP 404
LVL N +A +P +L + ++DN L P E + P++ L + P
Sbjct: 244 LLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPE--LLDAPFVRLQGNPLGEASP 300
Score = 93.6 bits (231), Expect = 9e-19
Identities = 83/239 (34%), Positives = 110/239 (46%), Gaps = 17/239 (7%)
Query: 59 PANLGDIEALNLGNNG----LEEVPEGLGSALGSLRVLVLRRNRFARLPPAVAELGHHLT 114
P L +E L L + LE L +L LR LVL+ + R A L LT
Sbjct: 58 PLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLKGGQ--RRDTLGACLRGALT 115
Query: 115 ELDVSHNRLTALGAEVVSALRELRKLNLSHNQLPALPAQLGALAHLEELDVSFNRLAHLP 174
L +S L L L+LS N L LPA + + L L +S N L+ LP
Sbjct: 116 NLPAG-----------LSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLSELP 164
Query: 175 DSLSCLSRLRTLDVDHNQLTAFPRQLLQLVALEELDVSSNRLRGLPEDISALRALKILWL 234
++L L L L V HN+L P L L L+ LD+S N L LP +I L +L L L
Sbjct: 165 EALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLELNL 224
Query: 235 SGAELGTLPAGFCELASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALL 293
+ L +LPA L SL L+L +N L ++PA + L L L+L N + P LL
Sbjct: 225 ASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLLTRLDLRDNQLRDLPPELL 283
Score = 72.4 bits (176), Expect = 2e-12
Identities = 69/224 (30%), Positives = 100/224 (44%), Gaps = 22/224 (9%)
Query: 198 RQLLQLVALEELDVSSNR--------LRGLPEDISALRALKILWLSGAELGTLPAGFCEL 249
+Q LQL+ +E L +S++ L LP+ +S LR+L + G TL G C
Sbjct: 56 QQPLQLLQVEFLRLSTHEDPQLLEATLAQLPQSLSCLRSLVLK--GGQRRDTL--GACLR 111
Query: 250 ASLESLMLDNNGLQALPAQFSCLQRLKMLNLSSNLFEEFPAALLPLAGLEELYLSRNQLT 309
+L +L PA S L L L+LS N E PA +L + GL L LS N L+
Sbjct: 112 GALTNL----------PAGLSGLAHLAHLDLSFNSLETLPACVLQMRGLGALLLSHNCLS 161
Query: 310 SVPSLISGLGRLLTLWLDNNRIRYLPDSIVELTGLEELVLQGNQIAVLPDHFGQLSRVGL 369
+P + L L L + +NR++ LP ++ L+ L+ L L N + LP G L +
Sbjct: 162 ELPEALGALPALTFLTVTHNRLQTLPPALGALSTLQRLDLSQNLLDTLPPEIGGLGSLLE 221
Query: 370 WKIKDNPLIQPPYEVCMKGIPYIAAYQKELAHSQPAVQPRLKLL 413
+ N L P + + L S PA RL LL
Sbjct: 222 LNLASNRLQSLPASLAGLRSLRLLVLHSNLLASVPADLARLPLL 265
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.415
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 43,877,040
Number of Sequences: 37866
Number of extensions: 2139708
Number of successful extensions: 9025
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 198
Number of HSP's successfully gapped in prelim test: 132
Number of HSP's that attempted gapping in prelim test: 5760
Number of HSP's gapped (non-prelim): 1272
length of query: 1052
length of database: 18,247,518
effective HSP length: 113
effective length of query: 939
effective length of database: 13,968,660
effective search space: 13116571740
effective search space used: 13116571740
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 67 (30.4 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.