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Search of human proteins with 110825974
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|110825974 ADAM metallopeptidase with thrombospondin type 1
motif, 2 isoform 1 preproprotein [Homo sapiens]
(1211 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|110825974 ADAM metallopeptidase with thrombospondin type 1 mo... 2567 0.0
gi|21265037 ADAM metallopeptidase with thrombospondin type 1 mot... 1389 0.0
gi|110611167 ADAM metallopeptidase with thrombospondin type 1 mo... 1283 0.0
gi|21265052 ADAM metallopeptidase with thrombospondin type 1 mot... 1271 0.0
gi|11038659 ADAM metallopeptidase with thrombospondin type 1 mot... 1127 0.0
gi|64276808 ADAM metallopeptidase with thrombospondin type 1 mot... 541 e-153
gi|40806187 ADAM metallopeptidase with thrombospondin type 1 mot... 514 e-145
gi|110735441 ADAM metallopeptidase with thrombospondin type 1 mo... 511 e-144
gi|38683827 ADAM metallopeptidase with thrombospondin type 1 mot... 499 e-141
gi|56121815 ADAM metallopeptidase with thrombospondin type 1 mot... 494 e-139
gi|33624896 ADAM metallopeptidase with thrombospondin type 1 mot... 476 e-134
gi|51558724 ADAM metallopeptidase with thrombospondin type 1 mot... 459 e-129
gi|124430557 a disintegrin-like and metalloprotease with thrombo... 454 e-127
gi|110611170 ADAM metallopeptidase with thrombospondin type 1 mo... 446 e-125
gi|112789555 ADAM metallopeptidase with thrombospondin type 1 mo... 446 e-125
gi|21265058 a disintegrin-like and metalloprotease (reprolysin t... 439 e-123
gi|50845384 ADAM metallopeptidase with thrombospondin type 1 mot... 402 e-111
gi|153792351 ADAM metallopeptidase with thrombospondin type 1 mo... 379 e-104
gi|195539372 ADAM metallopeptidase with thrombospondin type 1 mo... 346 9e-95
gi|73695936 ADAM metallopeptidase with thrombospondin type 1 mot... 333 8e-91
gi|21265034 ADAM metallopeptidase with thrombospondin type 1 mot... 333 8e-91
gi|157427675 ADAM metallopeptidase with thrombospondin type 1 mo... 331 2e-90
gi|21265043 ADAM metallopeptidase with thrombospondin type 1 mot... 317 4e-86
gi|145309328 papilin [Homo sapiens] 225 2e-58
gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens] 218 4e-56
gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens] 218 4e-56
gi|145275198 ADAMTS-like 3 precursor [Homo sapiens] 199 1e-50
gi|94536854 thrombospondin, type I, domain containing 4 [Homo sa... 164 6e-40
gi|223718260 ADAMTS-like 2 precursor [Homo sapiens] 157 4e-38
gi|41281450 ADAMTS-like 2 precursor [Homo sapiens] 157 4e-38
>gi|110825974 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 1 preproprotein [Homo sapiens]
Length = 1211
Score = 2567 bits (6653), Expect = 0.0
Identities = 1211/1211 (100%), Positives = 1211/1211 (100%)
Query: 1 MDPPAGAARRLLCPALLLLLLLLPPPLLPPPPPPANARLAAAADPPGGPLGHGAERILAV 60
MDPPAGAARRLLCPALLLLLLLLPPPLLPPPPPPANARLAAAADPPGGPLGHGAERILAV
Sbjct: 1 MDPPAGAARRLLCPALLLLLLLLPPPLLPPPPPPANARLAAAADPPGGPLGHGAERILAV 60
Query: 61 PVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDL 120
PVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDL
Sbjct: 61 PVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDL 120
Query: 121 HLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAG 180
HLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAG
Sbjct: 121 HLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAG 180
Query: 181 LIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDSLS 240
LIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDSLS
Sbjct: 181 LIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDSLS 240
Query: 241 RALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNE 300
RALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNE
Sbjct: 241 RALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNE 300
Query: 301 IYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYH 360
IYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYH
Sbjct: 301 IYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYH 360
Query: 361 DHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDG 420
DHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDG
Sbjct: 361 DHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDG 420
Query: 421 QGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQ 480
QGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQ
Sbjct: 421 QGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQ 480
Query: 481 LPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCA 540
LPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCA
Sbjct: 481 LPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCA 540
Query: 541 PGKHCFKGHCIWLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTC 600
PGKHCFKGHCIWLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTC
Sbjct: 541 PGKHCFKGHCIWLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTC 600
Query: 601 SGLAYDFQLCSRQDCPDSLADFREEQCRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYCE 660
SGLAYDFQLCSRQDCPDSLADFREEQCRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYCE
Sbjct: 601 SGLAYDFQLCSRQDCPDSLADFREEQCRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYCE 660
Query: 661 SRETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNS 720
SRETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNS
Sbjct: 661 SRETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNS 720
Query: 721 HCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEEND 780
HCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEEND
Sbjct: 721 HCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEEND 780
Query: 781 VDASSKTFIAMGVEWEYRDEDGRETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMIHEDS 840
VDASSKTFIAMGVEWEYRDEDGRETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMIHEDS
Sbjct: 781 VDASSKTFIAMGVEWEYRDEDGRETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMIHEDS 840
Query: 841 LNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSK 900
LNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSK
Sbjct: 841 LNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSK 900
Query: 901 PKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCN 960
PKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCN
Sbjct: 901 PKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCN 960
Query: 961 DARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQEERPETA 1020
DARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQEERPETA
Sbjct: 961 DARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQEERPETA 1020
Query: 1021 RTCRLGPCPRNISDPSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYC 1080
RTCRLGPCPRNISDPSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYC
Sbjct: 1021 RTCRLGPCPRNISDPSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYC 1080
Query: 1081 SIPGYNKLCCKSCNLYNNLTNVEGRIEPPPGKHNDIDVFMPTLPVPTVAMEVRPSPSTPL 1140
SIPGYNKLCCKSCNLYNNLTNVEGRIEPPPGKHNDIDVFMPTLPVPTVAMEVRPSPSTPL
Sbjct: 1081 SIPGYNKLCCKSCNLYNNLTNVEGRIEPPPGKHNDIDVFMPTLPVPTVAMEVRPSPSTPL 1140
Query: 1141 EVPLNASSTNATEDHPETNAVDEPYKIHGLEDEVQPPNLIPRRPSPYEKTRNQRIQELID 1200
EVPLNASSTNATEDHPETNAVDEPYKIHGLEDEVQPPNLIPRRPSPYEKTRNQRIQELID
Sbjct: 1141 EVPLNASSTNATEDHPETNAVDEPYKIHGLEDEVQPPNLIPRRPSPYEKTRNQRIQELID 1200
Query: 1201 EMRKKEMLGKF 1211
EMRKKEMLGKF
Sbjct: 1201 EMRKKEMLGKF 1211
>gi|21265037 ADAM metallopeptidase with thrombospondin type 1 motif, 3
proprotein [Homo sapiens]
Length = 1205
Score = 1389 bits (3594), Expect = 0.0
Identities = 656/1070 (61%), Positives = 797/1070 (74%), Gaps = 77/1070 (7%)
Query: 49 PLGHGAERILAVPVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSH 108
P+ E L PV T+ +GR +SH +SA+ + R + P
Sbjct: 35 PIKRYREYELVTPVSTNLEGRYLSHTLSASHKKRSARDVSSNP---------------EQ 79
Query: 109 LFYNVTVFGRDLHLRLRPNARLVAPGATMEW-----------------QGEKGTTRV--- 148
LF+N+T FG+D HLRL+PN +LVAPGA +EW Q T R+
Sbjct: 80 LFFNITAFGKDFHLRLKPNTQLVAPGAVVEWHETSLVPGNITDPINNHQPGSATYRIRKT 139
Query: 149 EPLLGSCLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQGRV 208
EPL +C YVGD+ + +SVA+SNCDGLAG+I+ + EE+FIEPLE+G +E E+GR+
Sbjct: 140 EPLQTNCAYVGDIVDIP-GTSVAISNCDGLAGMIKSDNEEYFIEPLERGKQMEE-EKGRI 197
Query: 209 HVVYRRPPTSP-PLGGPQALDTGAS-LDSLDSLSRALGVLEEHANSSRRRARRHAADDDY 266
HVVY+R P+ + S L+ LD L G + + N + RR RRHA ++DY
Sbjct: 198 HVVYKRSAVEQAPIDMSKDFHYRESDLEGLDDLGTVYGNIHQQLNETMRR-RRHAGENDY 256
Query: 267 NIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKS 326
NIEVLLGVDDSVV+FHGKEHVQ YLLTLMNIVNEIYHDESLG HINVVLVR+I+L Y KS
Sbjct: 257 NIEVLLGVDDSVVRFHGKEHVQNYLLTLMNIVNEIYHDESLGVHINVVLVRMIMLGYAKS 316
Query: 327 MSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPSGMQGYAPVTGMC 386
+SLIE GNPS+SLENVCRWA QQ+ D H E+HDHAIFLTRQDFGP+GMQGYAPVTGMC
Sbjct: 317 ISLIERGNPSRSLENVCRWASQQQRSDLNHSEHHDHAIFLTRQDFGPAGMQGYAPVTGMC 376
Query: 387 HPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRF 446
HPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDE +GS+MAPLVQAAFHR+
Sbjct: 377 HPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDETAMGSVMAPLVQAAFHRY 436
Query: 447 HWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAF 506
HWSRCS QEL RY+HSYDCLLDDPF HDWP LP+LPG++YSM+EQCRFDFG+GY MCTAF
Sbjct: 437 HWSRCSGQELKRYIHSYDCLLDDPFDHDWPKLPELPGINYSMDEQCRFDFGVGYKMCTAF 496
Query: 507 RTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGKHCFKGHCIWLTPDILKRDGSWGA 566
RTFDPCKQLWCSHPDNPYFCKTKKGPPLDGT CA GK C+KGHC+W + K+DG+WG+
Sbjct: 497 RTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTECAAGKWCYKGHCMWKNANQQKQDGNWGS 556
Query: 567 WSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLADFREEQ 626
W+ FGSCSRTCGTGV+FRTRQC+NP P NGG+ C G+ +++QLC+ ++C DFR +Q
Sbjct: 557 WTKFGSCSRTCGTGVRFRTRQCNNPMPINGGQDCPGVNFEYQLCNTEECQKHFEDFRAQQ 616
Query: 627 CRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYCESRETGEVVSMKRMVHDGTRCSYKDAF 686
C+Q + +FE+ + +HHWLP+EH D K+RCHLYC+S+ETG+V MK++VHDGT CSYKD +
Sbjct: 617 CQQRNSHFEYQNTKHHWLPYEHPDPKKRCHLYCQSKETGDVAYMKQLVHDGTHCSYKDPY 676
Query: 687 SLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPA 746
S+CVRG+C KVGCD IGS+K EDKCGVCGGDNSHC+ VKGTFTR+P+K GY+KMF+IP
Sbjct: 677 SICVRGECVKVGCDKEIGSNKVEDKCGVCGGDNSHCRTVKGTFTRTPRKLGYLKMFDIPP 736
Query: 747 GARHLLIQEVDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGVEWEYRDEDGRETL 806
GARH+LIQE +A+ H LA+KN TG +ILN + + +A S+TFI +GVEW+Y ED E+L
Sbjct: 737 GARHVLIQEDEASPHILAIKNQATGHYILNGKGE-EAKSRTFIDLGVEWDYNIEDDIESL 795
Query: 807 QTMGPLHGTITVLVIP-VGDTRVSLTYKYMIHEDSL-NVDDNNVLEEDSVVYEWALKKWS 864
T GPLH + VL+IP DTR SLTYKY+IHEDS+ ++ NNV++E+ +EWALK WS
Sbjct: 796 HTDGPLHDPVIVLIIPQENDTRSSLTYKYIIHEDSVPTINSNNVIQEELDTFEWALKSWS 855
Query: 865 PCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWE 924
CSKPCGGG Q+TKYGCRR+ D+KMVHR FC A KPK IRR CN QEC+ P+WV EWE
Sbjct: 856 QCSKPCGGGFQYTKYGCRRKSDNKMVHRSFCEANKKPKPIRRMCNIQECTHPLWVAEEWE 915
Query: 925 PCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCPGRWRAGPW 984
C++TCG +G Q+R+VRC+QPL D T RSVH+K+C RPESRR C+R CP +W+ GPW
Sbjct: 916 HCTKTCGSSGYQLRTVRCLQPLLDGTNRSVHSKYCMGDRPESRRPCNRVPCPAQWKTGPW 975
Query: 985 SQCSVTCGNGTQERPVLCRTADDSFGICQEERPETARTCRLGPCPRNISDPSKKSYVVQW 1044
S+CSVTCG GT+ R VLCR D C E+PE+ R C+L PC
Sbjct: 976 SECSVTCGEGTEVRQVLCRAGDH----CDGEKPESVRACQLPPC---------------- 1015
Query: 1045 LSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYCSIPGYNKLCCKSCN 1094
D P C GDKSIFC+MEVL+RYCSIPGYNKLCC+SC+
Sbjct: 1016 -----NDEP---------CLGDKSIFCQMEVLARYCSIPGYNKLCCESCS 1051
>gi|110611167 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 1 preproprotein [Homo sapiens]
Length = 1226
Score = 1283 bits (3319), Expect = 0.0
Identities = 635/1182 (53%), Positives = 793/1182 (67%), Gaps = 47/1182 (3%)
Query: 34 PANARLAAAADPPGGPL---GHGAERILAVPVRTDAQGRLVSHVVSA-ATSRAGVRARRA 89
P + L AAA L G ++ + VP TD +GR +SHVVS A + AG
Sbjct: 13 PLHCALCAAAGSRTPELHLSGKLSDYGVTVPCSTDFRGRFLSHVVSGPAAASAGSMVVDT 72
Query: 90 APV-----------RTPSFPGGN--EEEPGSH-LFYNVTVFGRDLHLRLRPNARLVAPGA 135
P R+P PGG G H L++NVTVFG++LHLRLRPN RLV PG+
Sbjct: 73 PPTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGS 132
Query: 136 TMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLE 195
++EWQ + +PL C+Y G V G+ A+ VA+SNCDGLAGLIR + +FFIEPLE
Sbjct: 133 SVEWQEDFRELFRQPLRQECVYTGGVTGMPGAA-VAISNCDGLAGLIRTDSTDFFIEPLE 191
Query: 196 KGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRR 255
+G +EA GR HVVYRR P D L L LG++ + + R
Sbjct: 192 RGQQEKEAS-GRTHVVYRREAVQQEWAEPDG-DLHNEAFGLGDLPNLLGLVGDQLGDTER 249
Query: 256 RARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVL 315
+ RRHA Y+IEVLL VDDSVV+FHGKEHVQ Y+LTLMNIV+EIYHDESLG HIN+ L
Sbjct: 250 K-RRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIAL 308
Query: 316 VRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPSG 375
VR+I++ Y +S+SLIE GNPS+SLE VCRWA+ QQ+ D H E+HDH +FLTRQDFGPSG
Sbjct: 309 VRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPSG 368
Query: 376 MQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVRLGSIM 435
MQGYAPVTGMCHP+RSC LNHEDGFSSAFV+AHETGHVLGMEHDGQGN C DE LGS+M
Sbjct: 369 MQGYAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVM 428
Query: 436 APLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQLPGLHYSMNEQCRFD 495
APLVQAAFHRFHWSRCS+ ELSRYL SYDCLLDDPF WP P+LPG++YSM+EQCRFD
Sbjct: 429 APLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINYSMDEQCRFD 488
Query: 496 FGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGKHCFKGHCIWLTP 555
FG GY C AFRTF+PCKQLWCSHPDNPYFCKTKKGPPLDGT CAPGK CFKGHCIW +P
Sbjct: 489 FGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSP 548
Query: 556 D-ILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQD 614
+ +DG W +W+ FGSCSR+CG GV+ R+R C+NP PA GGR C G +++Q+C+ ++
Sbjct: 549 EQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEE 608
Query: 615 CPDSLADFREEQCRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYCESRETGEVVSMKRMV 674
CP + DFR +QC + + Y+ H +A+H W+P+E D ++C L C+S +TG+VV M ++V
Sbjct: 609 CPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVV 668
Query: 675 HDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPK 734
HDGTRCSY+D +S+C RG+C VGCD +GS K +DKCGVCGGDNSHC+ VKGT ++ K
Sbjct: 669 HDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASK 728
Query: 735 KHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGVE 794
+ G +K+ +IPAGARH+ I+ ++ + H + VKN TG FILN + +A+S+TF AMG+E
Sbjct: 729 QAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGK-EATSRTFTAMGLE 787
Query: 795 WEYRDEDGRETLQTMGPLHGTITVLVIP--VGDTRVSLTYKYMIHEDSLN-VDDNNVLEE 851
WE ED +E+L+T GPL I +L +P G R SL YKY+IHED L + NNVL E
Sbjct: 788 WEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLE 847
Query: 852 DSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQ 911
+ YEWALK W+PCSK CGGG QFTKYGCRRR DH MV R C +PK IRR CN
Sbjct: 848 EMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQH 907
Query: 912 ECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACS 971
CSQPVWVT EW CS++CG+ G+Q R ++C+ PL + T + + AK C RPE+RR C
Sbjct: 908 PCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCL 967
Query: 972 RELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQEERPETARTCRLGPCPRN 1031
R CP +WR G WSQCS TCG G Q+R V+CRT +S G C+ +RP+T + C L C N
Sbjct: 968 RVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPACGGN 1027
Query: 1032 ISDPSKKSYV-------VQWLSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYCSIPG 1084
+ + ++ V QW+ + +P PI KISS C GD+S+FC+MEVL RYCSIPG
Sbjct: 1028 HQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPG 1087
Query: 1085 YNKLCCKSCNLYNNLTNVEGRIEPPPGKHNDIDVFMPTLPVPTVAMEVRPSPSTPLEVPL 1144
Y++LCC SC ++ P PG D +LP + P P P +
Sbjct: 1088 YHRLCCVSC--------IKKASGPNPGP----DPGPTSLPPFSTPGSPLPGPQDPADAAE 1135
Query: 1145 NASSTNATEDHPETNAVDEPYKIHGLEDEVQPPNLIPRRPSP 1186
+EDH A P + Q P P P P
Sbjct: 1136 PPGKPTGSEDHQHGRATQLPGALDTSSPGTQHP-FAPETPIP 1176
Score = 31.2 bits (69), Expect = 6.3
Identities = 26/81 (32%), Positives = 32/81 (39%), Gaps = 8/81 (9%)
Query: 23 LPPPLLPPPPPPANARLAAAADPPGGPLG---HGAERILAVPVRTDAQGRLVSHVVSAAT 79
LPP P P P A AA+PPG P G H R +P D H + T
Sbjct: 1114 LPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQLPGALDTSSPGTQHPFAPET 1173
Query: 80 SRAGVRARRAAPVRTPSFPGG 100
G A+ +P+ PGG
Sbjct: 1174 PIPG-----ASWSISPTTPGG 1189
>gi|21265052 ADAM metallopeptidase with thrombospondin type 1 motif,
14 isoform 2 preproprotein [Homo sapiens]
Length = 1223
Score = 1271 bits (3289), Expect = 0.0
Identities = 632/1182 (53%), Positives = 790/1182 (66%), Gaps = 50/1182 (4%)
Query: 34 PANARLAAAADPPGGPL---GHGAERILAVPVRTDAQGRLVSHVVSA-ATSRAGVRARRA 89
P + L AAA L G ++ + VP TD +GR +SHVVS A + AG
Sbjct: 13 PLHCALCAAAGSRTPELHLSGKLSDYGVTVPCSTDFRGRFLSHVVSGPAAASAGSMVVDT 72
Query: 90 APV-----------RTPSFPGGN--EEEPGSH-LFYNVTVFGRDLHLRLRPNARLVAPGA 135
P R+P PGG G H L++NVTVFG++LHLRLRPN RLV PG+
Sbjct: 73 PPTLPRHSSHLRVARSPLHPGGTLWPGRVGRHSLYFNVTVFGKELHLRLRPNRRLVVPGS 132
Query: 136 TMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLE 195
++EWQ + +PL C+Y G V G+ A+ VA+SNCDGLAGLIR + +FFIEPLE
Sbjct: 133 SVEWQEDFRELFRQPLRQECVYTGGVTGMPGAA-VAISNCDGLAGLIRTDSTDFFIEPLE 191
Query: 196 KGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRR 255
+G +EA GR HVVYRR P D L L LG++ + + R
Sbjct: 192 RGQQEKEAS-GRTHVVYRREAVQQEWAEPDG-DLHNEAFGLGDLPNLLGLVGDQLGDTER 249
Query: 256 RARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVL 315
+ RRHA Y+IEVLL VDDSVV+FHGKEHVQ Y+LTLMNIV+EIYHDESLG HIN+ L
Sbjct: 250 K-RRHAKPGSYSIEVLLVVDDSVVRFHGKEHVQNYVLTLMNIVDEIYHDESLGVHINIAL 308
Query: 316 VRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPSG 375
VR+I++ Y +S+SLIE GNPS+SLE VCRWA+ QQ+ D H E+HDH +FLTRQDFGPSG
Sbjct: 309 VRLIMVGYRQSLSLIERGNPSRSLEQVCRWAHSQQRQDPSHAEHHDHVVFLTRQDFGPSG 368
Query: 376 MQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVRLGSIM 435
YAPVTGMCHP+RSC LNHEDGFSSAFV+AHETGHVLGMEHDGQGN C DE LGS+M
Sbjct: 369 ---YAPVTGMCHPLRSCALNHEDGFSSAFVIAHETGHVLGMEHDGQGNGCADETSLGSVM 425
Query: 436 APLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQLPGLHYSMNEQCRFD 495
APLVQAAFHRFHWSRCS+ ELSRYL SYDCLLDDPF WP P+LPG++YSM+EQCRFD
Sbjct: 426 APLVQAAFHRFHWSRCSKLELSRYLPSYDCLLDDPFDPAWPQPPELPGINYSMDEQCRFD 485
Query: 496 FGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGKHCFKGHCIWLTP 555
FG GY C AFRTF+PCKQLWCSHPDNPYFCKTKKGPPLDGT CAPGK CFKGHCIW +P
Sbjct: 486 FGSGYQTCLAFRTFEPCKQLWCSHPDNPYFCKTKKGPPLDGTECAPGKWCFKGHCIWKSP 545
Query: 556 D-ILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQD 614
+ +DG W +W+ FGSCSR+CG GV+ R+R C+NP PA GGR C G +++Q+C+ ++
Sbjct: 546 EQTYGQDGGWSSWTKFGSCSRSCGGGVRSRSRSCNNPSPAYGGRLCLGPMFEYQVCNSEE 605
Query: 615 CPDSLADFREEQCRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYCESRETGEVVSMKRMV 674
CP + DFR +QC + + Y+ H +A+H W+P+E D ++C L C+S +TG+VV M ++V
Sbjct: 606 CPGTYEDFRAQQCAKRNSYYVHQNAKHSWVPYEPDDDAQKCELICQSADTGDVVFMNQVV 665
Query: 675 HDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPK 734
HDGTRCSY+D +S+C RG+C VGCD +GS K +DKCGVCGGDNSHC+ VKGT ++ K
Sbjct: 666 HDGTRCSYRDPYSVCARGECVPVGCDKEVGSMKADDKCGVCGGDNSHCRTVKGTLGKASK 725
Query: 735 KHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGVE 794
+ G +K+ +IPAGARH+ I+ ++ + H + VKN TG FILN + +A+S+TF AMG+E
Sbjct: 726 QAGALKLVQIPAGARHIQIEALEKSPHRIVVKNQVTGSFILNPKGK-EATSRTFTAMGLE 784
Query: 795 WEYRDEDGRETLQTMGPLHGTITVLVIP--VGDTRVSLTYKYMIHEDSLN-VDDNNVLEE 851
WE ED +E+L+T GPL I +L +P G R SL YKY+IHED L + NNVL E
Sbjct: 785 WEDAVEDAKESLKTSGPLPEAIAILALPPTEGGPRSSLAYKYVIHEDLLPLIGSNNVLLE 844
Query: 852 DSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQ 911
+ YEWALK W+PCSK CGGG QFTKYGCRRR DH MV R C +PK IRR CN
Sbjct: 845 EMDTYEWALKSWAPCSKACGGGIQFTKYGCRRRRDHHMVQRHLCDHKKRPKPIRRRCNQH 904
Query: 912 ECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACS 971
CSQPVWVT EW CS++CG+ G+Q R ++C+ PL + T + + AK C RPE+RR C
Sbjct: 905 PCSQPVWVTEEWGACSRSCGKLGVQTRGIQCLLPLSNGTHKVMPAKACAGDRPEARRPCL 964
Query: 972 RELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQEERPETARTCRLGPCPRN 1031
R CP +WR G WSQCS TCG G Q+R V+CRT +S G C+ +RP+T + C L C N
Sbjct: 965 RVPCPAQWRLGAWSQCSATCGEGIQQRQVVCRTNANSLGHCEGDRPDTVQVCSLPACGGN 1024
Query: 1032 ISDPSKKSYV-------VQWLSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYCSIPG 1084
+ + ++ V QW+ + +P PI KISS C GD+S+FC+MEVL RYCSIPG
Sbjct: 1025 HQNSTVRADVWELGTPEGQWVPQSEPLHPINKISSTEPCTGDRSVFCQMEVLDRYCSIPG 1084
Query: 1085 YNKLCCKSCNLYNNLTNVEGRIEPPPGKHNDIDVFMPTLPVPTVAMEVRPSPSTPLEVPL 1144
Y++LCC SC ++ P PG D +LP + P P P +
Sbjct: 1085 YHRLCCVSC--------IKKASGPNPGP----DPGPTSLPPFSTPGSPLPGPQDPADAAE 1132
Query: 1145 NASSTNATEDHPETNAVDEPYKIHGLEDEVQPPNLIPRRPSP 1186
+EDH A P + Q P P P P
Sbjct: 1133 PPGKPTGSEDHQHGRATQLPGALDTSSPGTQHP-FAPETPIP 1173
Score = 31.2 bits (69), Expect = 6.3
Identities = 26/81 (32%), Positives = 32/81 (39%), Gaps = 8/81 (9%)
Query: 23 LPPPLLPPPPPPANARLAAAADPPGGPLG---HGAERILAVPVRTDAQGRLVSHVVSAAT 79
LPP P P P A AA+PPG P G H R +P D H + T
Sbjct: 1111 LPPFSTPGSPLPGPQDPADAAEPPGKPTGSEDHQHGRATQLPGALDTSSPGTQHPFAPET 1170
Query: 80 SRAGVRARRAAPVRTPSFPGG 100
G A+ +P+ PGG
Sbjct: 1171 PIPG-----ASWSISPTTPGG 1186
>gi|11038659 ADAM metallopeptidase with thrombospondin type 1 motif,
2 isoform 2 [Homo sapiens]
Length = 566
Score = 1127 bits (2916), Expect = 0.0
Identities = 543/543 (100%), Positives = 543/543 (100%)
Query: 1 MDPPAGAARRLLCPALLLLLLLLPPPLLPPPPPPANARLAAAADPPGGPLGHGAERILAV 60
MDPPAGAARRLLCPALLLLLLLLPPPLLPPPPPPANARLAAAADPPGGPLGHGAERILAV
Sbjct: 1 MDPPAGAARRLLCPALLLLLLLLPPPLLPPPPPPANARLAAAADPPGGPLGHGAERILAV 60
Query: 61 PVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDL 120
PVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDL
Sbjct: 61 PVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDL 120
Query: 121 HLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAG 180
HLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAG
Sbjct: 121 HLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAG 180
Query: 181 LIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDSLS 240
LIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDSLS
Sbjct: 181 LIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRRPPTSPPLGGPQALDTGASLDSLDSLS 240
Query: 241 RALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNE 300
RALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNE
Sbjct: 241 RALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNE 300
Query: 301 IYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYH 360
IYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYH
Sbjct: 301 IYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYH 360
Query: 361 DHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDG 420
DHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDG
Sbjct: 361 DHAIFLTRQDFGPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDG 420
Query: 421 QGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQ 480
QGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQ
Sbjct: 421 QGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQ 480
Query: 481 LPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCA 540
LPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCA
Sbjct: 481 LPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCA 540
Query: 541 PGK 543
PGK
Sbjct: 541 PGK 543
>gi|64276808 ADAM metallopeptidase with thrombospondin type 1 motif, 6
preproprotein [Homo sapiens]
Length = 1117
Score = 541 bits (1394), Expect = e-153
Identities = 344/1110 (30%), Positives = 545/1110 (49%), Gaps = 113/1110 (10%)
Query: 58 LAVPVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFG 117
L +P+R D G +S V + R R P+ + ++ S LF+ ++ +G
Sbjct: 44 LTIPIRVDQNGAFLSFTVK--NDKHSRRRRSMDPI--------DPQQAVSKLFFKLSAYG 93
Query: 118 RDLHLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCDG 177
+ HL L N V+ T+E+ G+ G L +C Y G + + VALSNC G
Sbjct: 94 KHFHLNLTLNTDFVSKHFTVEYWGKDGPQWKHDFLDNCHYTGYLQDQRSTTKVALSNCVG 153
Query: 178 LAGLIRMEEEEFFIEPLEKGLAAQEA---EQGRVHVVYRRPPTSPP-------LGGPQAL 227
L G+I E+EE+FIEPL+ + E G HV+Y++ G
Sbjct: 154 LHGVIATEDEEYFIEPLKNTTEDSKHFSYENGHPHVIYKKSALQQRHLYDHSHCGVSDFT 213
Query: 228 DTGAS--LDSLDSLSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKE 285
+G L+ ++S +L + H + ++R+ + +E L+ D +V +HG++
Sbjct: 214 RSGKPWWLNDTSTVSYSLPINNTHIHHRQKRS----VSIERFVETLVVADKMMVGYHGRK 269
Query: 286 HVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPS-QSLENVCR 344
++ Y+L++MNIV ++Y D SLG +N+++ R+I+L+ + +EI + + +SL++ C+
Sbjct: 270 DIEHYILSVMNIVAKLYRDSSLGNVVNIIVARLIVLT--EDQPNLEINHHADKSLDSFCK 327
Query: 345 WAYLQQKPDTGHDE-----------YHDHAIFLTRQDF-----GPSGMQGYAPVTGMCHP 388
W QK H +HD+A+ +TR D P G G A V GMC P
Sbjct: 328 W----QKSILSHQSDGNTIPENGIAHHDNAVLITRYDICTYKNKPCGTLGLASVAGMCEP 383
Query: 389 VRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVR-LGSIMAPLVQAAFHRFH 447
RSC++N + G SAF +AHE GH GM HDG GN CG + +MA + A + F
Sbjct: 384 ERSCSINEDIGLGSAFTIAHEIGHNFGMNHDGIGNSCGTKGHEAAKLMAAHITANTNPFS 443
Query: 448 WSRCSQQELSRYLHSY--DCLLDDPFAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTA 505
WS CS+ ++ +L S CL ++P D+ PG Y +EQCRF +G C
Sbjct: 444 WSACSRDYITSFLDSGRGTCLDNEPPKRDFLYPAVAPGQVYDADEQCRFQYGATSRQC-- 501
Query: 506 FRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGK----HCFKGHCIWLTPDILKRD 561
+ + C++LWC N C T P +GT+C G C++G C+ D
Sbjct: 502 -KYGEVCRELWCLSKSNR--CVTNSIPAAEGTLCQTGNIEKGWCYQGDCVPFGTWPQSID 558
Query: 562 GSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLAD 621
G WG WS +G CSRTCG GV R CD+P P+ GG+ C G ++ C+ CP D
Sbjct: 559 GGWGPWSLWGECSRTCGGGVSSSLRHCDSPAPSGGGKYCLGERKRYRSCNTDPCPLGSRD 618
Query: 622 FREEQCRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYCESRETGEVVSMKRMVHDGTRCS 681
FRE+QC +D G ++W P+ K C L C + V DGT+C+
Sbjct: 619 FREKQCADFDNMPFRGK-YYNWKPYTGGGVKP-CALNCLAEGYNFYTERAPAVIDGTQCN 676
Query: 682 YKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIKM 741
D+ +C+ G+C+ VGCD ++GS +ED+C VCGGD S C ++G F S + GY+++
Sbjct: 677 -ADSLDICINGECKHVGCDNILGSDAREDRCRVCGGDGSTCDAIEGFFNDSLPRGGYMEV 735
Query: 742 FEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGVEWEY-RDE 800
+IP G+ H+ ++EV + +++A+K+ E + +N +D K F G + Y R
Sbjct: 736 VQIPRGSVHIEVREVAMSKNYIALKS-EGDDYYINGAWTIDWPRK-FDVAGTAFHYKRPT 793
Query: 801 DGRETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYEWAL 860
D E+L+ +GP + V+V+ + + + + YK+ + DN V + W
Sbjct: 794 DEPESLEALGPTSENLIVMVL-LQEQNLGIRYKFNVPITRTGSGDN------EVGFTWNH 846
Query: 861 KKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVT 920
+ WS CS C GG Q + C+R D+ +V +C SKP +RACN + C P W
Sbjct: 847 QPWSECSATCAGGVQRQEVVCKRLDDNSIVQNNYCDPDSKPPENQRACNTEPC-PPEWFI 905
Query: 921 GEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCPGRWR 980
G+W CS+TC GM+ R+V CI+ + + ++ C RP + C+ + CP +W
Sbjct: 906 GDWLECSKTCD-GGMRTRAVLCIRKIGPSEEETLDYSGCLTHRPVEKEPCNNQSCPPQWV 964
Query: 981 AGPWSQCSVTCGNGTQERPVLCRTAD--DSFGICQ---EERPETARTCRLGPC--PRNIS 1033
A WS+C+ CG G + R VLC+++D +F Q E +P C LG C PR ++
Sbjct: 965 ALDWSECTPKCGPGFKHRIVLCKSSDLSKTFPAAQCPEESKPPVRIRCSLGRCPPPRWVT 1024
Query: 1034 DP----------SKKSYVVQWLS-------------RP------DPDSPIRKISSKGHCQ 1064
++ VQ LS RP + IS+ C+
Sbjct: 1025 GDWGQCSAQCGLGQQMRTVQCLSYTGQASSDCLETVRPPSMQQCESKCDSTPISNTEECK 1084
Query: 1065 G-DKSIFCRMEVLSRYCSIPGYNKLCCKSC 1093
+K +C + + ++CS + ++CCK+C
Sbjct: 1085 DVNKVAYCPLVLKFKFCSRAYFRQMCCKTC 1114
>gi|40806187 ADAM metallopeptidase with thrombospondin type 1 motif,
18 preproprotein [Homo sapiens]
Length = 1221
Score = 514 bits (1324), Expect = e-145
Identities = 346/1054 (32%), Positives = 510/1054 (48%), Gaps = 99/1054 (9%)
Query: 35 ANARLAAAADPPGGPLGHGAERILAVPVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRT 94
A+ A A+D G G + + PV D+ G +SH + G + R A R
Sbjct: 40 ASVAAALASDSSSGASGLNDDYVFVTPVEVDSAGSYISHDIL----HNGRKKRSAQNAR- 94
Query: 95 PSFPGGNEEEPGSHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGTTRVE-PLLG 153
S L Y + FG++LHL L+P+A +++ ++ G+ G + + P +
Sbjct: 95 ------------SSLHYRFSAFGQELHLELKPSA-ILSSHFIVQVLGKDGASETQKPEVQ 141
Query: 154 SCLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQGRV----H 209
C Y G + +SSVA+S C GL+GLIR + EF I PL + LA + H
Sbjct: 142 QCFYQGFIRN-DSSSSVAVSTCAGLSGLIRTRKNEFLISPLPQLLAQEHNYSSPAGHHPH 200
Query: 210 VVYRRPPTSP--------------PLGGPQALDTGASLDSLDSLSRALGV---------- 245
V+Y+R P P + + + R L
Sbjct: 201 VLYKRTAEEKIQRYRGYPGSGRNYPGYSPSHIPHASQSRETEYHHRRLQKQHFCGRRKKY 260
Query: 246 ------------LEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLT 293
+E+ +S R R + N+E L+ D +V+ HGK +V Y+LT
Sbjct: 261 APKPPTEDTYLRFDEYGSSGRPRRSAGKSQKGLNVETLVVADKKMVEKHGKGNVTTYILT 320
Query: 294 LMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPD 353
+MN+V+ ++ D ++G+ INVV+V +ILL LI + QSL + C+W Q
Sbjct: 321 VMNMVSGLFKDGTIGSDINVVVVSLILLEQEPGGLLIN-HHADQSLNSFCQW---QSALI 376
Query: 354 TGHDEYHDHAIFLTRQDF-----GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAH 408
+ + HDHAI LT D P G+AP++GMC RSCT+N + G AF +AH
Sbjct: 377 GKNGKRHDHAILLTGFDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGLAFTIAH 436
Query: 409 ETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYD--CL 466
E+GH GM HDG+GN C G+IM+P + F WS CS+Q L ++L + CL
Sbjct: 437 ESGHNFGMIHDGEGNPCRKAE--GNIMSPTLTGNNGVFSWSSCSRQYLKKFLSTPQAGCL 494
Query: 467 LDDPF-AHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYF 525
+D+P A + +LPG Y + QC++ FG +C+ D CK LWC +
Sbjct: 495 VDEPKQAGQYKYPDKLPGQIYDADTQCKWQFGAKAKLCSLGFVKDICKSLWCHRVGHR-- 552
Query: 526 CKTKKGPPLDGTMCAPGKHCFKGHCIW---LTPDILKRDGSWGAWSPFGSCSRTCGTGVK 582
C+TK P +GT+C C +G C+ L P + G W AWS + CSRTCG GVK
Sbjct: 553 CETKFMPAAEGTVCGLSMWCRQGQCVKFGELGPRPIH--GQWSAWSKWSECSRTCGGGVK 610
Query: 583 FRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLADFREEQCRQWDLYFEHGDAQHH 642
F+ R C+NP P GG C G + +QLC+ C ++ DFR +QC +++ G +
Sbjct: 611 FQERHCNNPKPQYGGLFCPGSSRIYQLCNINPCNENSLDFRAQQCAEYNSKPFRG-WFYQ 669
Query: 643 WLPHEHRDAKERCHLYCESRETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGV 702
W P+ + ++RC LYC++ +M V DGT CS + +C+ G C VGCD
Sbjct: 670 WKPYTKVEEEDRCKLYCKAENFEFFFAMSGKVKDGTPCS-PNKNDVCIDGVCELVGCDHE 728
Query: 703 IGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSHH 762
+GS D CGVC GDNS CK KG + K + Y + IPAGAR + IQE+ +S +
Sbjct: 729 LGSKAVSDACGVCKGDNSTCKFYKGLYLNQHKANEYYPVVLIPAGARSIEIQELQVSSSY 788
Query: 763 LAVKNLETGKFILNEENDVDASSKTFIAMGVEWEYRDEDGR-ETLQTMGPLHGTITVLVI 821
LAV++L + K+ L +D + F G +EY+ R E L GP + T+ ++
Sbjct: 789 LAVRSL-SQKYYLTGGWSIDWPGE-FPFAGTTFEYQRSFNRPERLYAPGPTNETLVFEIL 846
Query: 822 PVGDTRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGC 881
G + +KY + + V + Y W++ + S CS CGGG K C
Sbjct: 847 MQG-KNPGIAWKYALPK----VMNGTPPATKRPAYTWSIVQ-SECSVSCGGGYINVKAIC 900
Query: 882 RRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVR 941
R + V+ FC+A +KP + CN C W+ GEW CS+ C G Q R ++
Sbjct: 901 LRD-QNTQVNSSFCSAKTKPVTEPKICNAFSC-PAYWMPGEWSTCSKACA-GGQQSRKIQ 957
Query: 942 CIQPLHDNTTRSVHAKHCNDARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVL 1001
C+Q +V C + P +AC+ CP +W GPWSQCS TCG G ++R +L
Sbjct: 958 CVQKKPFQKEEAVLHSLCPVSTPTQVQACNSHACPPQWSLGPWSQCSKTCGRGVRKRELL 1017
Query: 1002 CR-TADDSFGICQ---EERPETARTCRLGPCPRN 1031
C+ +A ++ Q RPE C LG CP+N
Sbjct: 1018 CKGSAAETLPESQCTSLPRPELQEGCVLGRCPKN 1051
Score = 95.9 bits (237), Expect = 2e-19
Identities = 68/252 (26%), Positives = 99/252 (39%), Gaps = 43/252 (17%)
Query: 857 EWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQEC--- 913
+W+L WS CSK CG G + + C+ + C +L +P+ ++ C C
Sbjct: 994 QWSLGPWSQCSKTCGRGVRKRELLCKGSAAETLPESQ-CTSLPRPE-LQEGCVLGRCPKN 1051
Query: 914 SQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPES---RRAC 970
S+ WV W CS TCG G++ R ++C + + + C + + + C
Sbjct: 1052 SRLQWVASSWSECSATCG-LGVRKREMKCSEKGFQGKLITFPERRCRNIKKPNLDLEETC 1110
Query: 971 SRELCPGR--------WRAGPWSQCSVTCGNGTQERPVLC-RTADDSFGICQEERPETAR 1021
+R CP W + PW QC+VTCG G Q R V C + S ++P R
Sbjct: 1111 NRRACPAHPVYNMVAGWYSLPWQQCTVTCGGGVQTRSVHCVQQGRPSSSCLLHQKPPVLR 1170
Query: 1022 TCRLGPCPRNISDPSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYCS 1081
C CP P K R DP D +C + C+
Sbjct: 1171 ACNTNFCPA----PEK---------REDPSCV------------DFFNWCHLVPQHGVCN 1205
Query: 1082 IPGYNKLCCKSC 1093
Y K CCKSC
Sbjct: 1206 HKFYGKQCCKSC 1217
>gi|110735441 ADAM metallopeptidase with thrombospondin type 1 motif,
16 preproprotein [Homo sapiens]
Length = 1224
Score = 511 bits (1315), Expect = e-144
Identities = 354/1076 (32%), Positives = 518/1076 (48%), Gaps = 115/1076 (10%)
Query: 26 PLLPPPPPPANARLAAAADPPGGPLGHGAERILAVPVRTDAQGRLVSHVVSAATSRAGVR 85
P +P PPPPA + PG E L D +G VSH + R
Sbjct: 40 PSVPRPPPPA--------ERPGWM--EKGEYDLVSAYEVDHRGDYVSHEIMHHQRR---- 85
Query: 86 ARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGT 145
RRA PV E HL + D H+ LR ++ LVAPG ++ G+ GT
Sbjct: 86 -RRAVPV---------SEVESLHL--RLKGSRHDFHMDLRTSSSLVAPGFIVQTLGKTGT 133
Query: 146 TRVEPLLGS--CLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAQ-- 201
V+ L C Y G + SSVALS C GL+G+IR EE ++F+ PL L+ +
Sbjct: 134 KSVQTLPPEDFCFYQGSLRSHRN-SSVALSTCQGLSGMIRTEEADYFLRPLPSHLSWKLG 192
Query: 202 EAEQGRV--HVVYRRPPTSPPLGGPQALDTGASLD----SLDSLSRALG----------- 244
A QG HV+Y+R G + L T + + L S LG
Sbjct: 193 RAAQGSSPSHVLYKRSTEPHAPGASEVLVTSRTWELAHQPLHSSDLRLGLPQKQHFCGRR 252
Query: 245 -------------VLEEHANSSRRRAR---RHAADDDYNIEVLLGVDDSVVQFHGKEHVQ 288
+L + S R R R +++ N+E L+ VD ++Q HG E++
Sbjct: 253 KKYMPQPPKEDLFILPDEYKSCLRHKRSLLRSHRNEELNVETLVVVDKKMMQNHGHENIT 312
Query: 289 KYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYL 348
Y+LT++N+V+ ++ D ++G +IN+ +V +ILL + L+ + +L + C+W
Sbjct: 313 TYVLTILNMVSALFKDGTIGGNINIAIVGLILLE-DEQPGLVISHHADHTLSSFCQW--- 368
Query: 349 QQKPDTGHD-EYHDHAIFLTRQDF-----GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSS 402
Q G D HDHAI LT D P G+AP++GMC RSCT+N + G
Sbjct: 369 -QSGLMGKDGTRHDHAILLTGLDICSWKNEPCDTLGFAPISGMCSKYRSCTINEDTGLGL 427
Query: 403 AFVVAHETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHS 462
AF +AHE+GH GM HDG+GN C G+IM+P + F WS CS+Q L ++L +
Sbjct: 428 AFTIAHESGHNFGMIHDGEGNMCKKSE--GNIMSPTLAGRNGVFSWSPCSRQYLHKFLST 485
Query: 463 YD--CLLDDPF-AHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSH 519
CL D P ++ +LPG Y N QC++ FG +C D CK LWC
Sbjct: 486 AQAICLADQPKPVKEYKYPEKLPGELYDANTQCKWQFGEKAKLCMLDFKKDICKALWCHR 545
Query: 520 PDNPYFCKTKKGPPLDGTMCAPGKHCFKGHCIWLTPDILK-RDGSWGAWSPFGSCSRTCG 578
C+TK P +GT+C C G C+ + K G W WS + CSRTCG
Sbjct: 546 IGRK--CETKFMPAAEGTICGHDMWCRGGQCVKYGDEGPKPTHGHWSDWSSWSPCSRTCG 603
Query: 579 TGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLADFREEQCRQWDLYFEHGD 638
GV R+R C NP P++GG+ C G +LC+ Q CP DFR QC + + G
Sbjct: 604 GGVSHRSRLCTNPKPSHGGKFCEGSTRTLKLCNSQKCPRDSVDFRAAQCAEHNSRRFRG- 662
Query: 639 AQHHWLPHEHRDAKERCHLYCESRETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVG 698
+ W P+ + ++ C LYC + S+ V DGT CS +D+ ++C+ G C +VG
Sbjct: 663 RHYKWKPYTQVEDQDLCKLYCIAEGFDFFFSLSNKVKDGTPCS-EDSRNVCIDGICERVG 721
Query: 699 CDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDA 758
CD V+GS ED CGVC G+NS C + +G +T+ + Y M IP+GAR + I E++
Sbjct: 722 CDNVLGSDAVEDVCGVCNGNNSACTIHRGLYTKHHHTNQYYHMVTIPSGARSIRIYEMNV 781
Query: 759 TSHHLAVKNLETGKFILNEENDVDASSKTFIAMGVEWEY-RDEDGRETLQTMGPLHGTIT 817
++ +++V+N ++ LN VD + + G ++Y R + E L GP + T+
Sbjct: 782 STSYISVRN-ALRRYYLNGHWTVDWPGR-YKFSGTTFDYRRSYNEPENLIATGPTNETLI 839
Query: 818 VLVIPVGDTRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFT 877
V ++ G + ++Y + L + + Y WA+ + S CS CGGG
Sbjct: 840 VELLFQG-RNPGVAWEYSM--PRLGTEKQPPAQPS---YTWAIVR-SECSVSCGGGQMTV 892
Query: 878 KYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQV 937
+ GC R L + V+ FC ++P C C P W G W CS+TCG G Q
Sbjct: 893 REGCYRDLKFQ-VNMSFCNPKTRPVTGLVPCKVSAC-PPSWSVGNWSACSRTCG-GGAQS 949
Query: 938 RSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQE 997
R V+C + +H + + V A C P SR+AC+ + CP W AGPW++CS TCG G ++
Sbjct: 950 RPVQCTRRVHYD-SEPVPASLCPQPAPSSRQACNSQSCPPAWSAGPWAECSHTCGKGWRK 1008
Query: 998 RPVLCRTADDSF-------GIC-QEERPETARTCRLGPCPRNISDPSKKSYVVQWL 1045
R V C++ + S +C E +P C L C + P K +QWL
Sbjct: 1009 RAVACKSTNPSARAQLLPDAVCTSEPKPRMHEACLLQRCHK----PKK----LQWL 1056
Score = 92.4 bits (228), Expect = 2e-18
Identities = 71/263 (26%), Positives = 100/263 (38%), Gaps = 52/263 (19%)
Query: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDH---KMVHRGFCAALSKPKAIRRACNPQECS 914
W+ W+ CS CG G + C+ +++ C + KP+ + AC Q C
Sbjct: 990 WSAGPWAECSHTCGKGWRKRAVACKSTNPSARAQLLPDAVCTSEPKPR-MHEACLLQRCH 1048
Query: 915 QPV---WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDA-RP--ESRR 968
+P W+ W CS TC R G Q R ++C + R + +K C+ +P E R
Sbjct: 1049 KPKKLQWLVSAWSQCSVTCER-GTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELER 1107
Query: 969 ACSRELCP------------GRWRAGPWSQCSVTCGNGTQERPVLCRTAD-DSFGICQEE 1015
AC+ CP G W A PWSQC+ +CG G Q R V C + G +
Sbjct: 1108 ACAPLPCPRHPPFAAAGPSRGSWFASPWSQCTASCGGGVQTRSVQCLAGGRPASGCLLHQ 1167
Query: 1016 RPETARTCRLGPCP-RNISDPSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSIFCRME 1074
+P + C CP D K Y W C +
Sbjct: 1168 KPSASLACNTHFCPIAEKKDAFCKDY-FHW--------------------------CYLV 1200
Query: 1075 VLSRYCSIPGYNKLCCKSCNLYN 1097
CS Y K CCK+C+ N
Sbjct: 1201 PQHGMCSHKFYGKQCCKTCSKSN 1223
Score = 55.8 bits (133), Expect = 2e-07
Identities = 37/135 (27%), Positives = 56/135 (41%), Gaps = 22/135 (16%)
Query: 857 EWALKKWSPCSKPCGGGSQFTKYGCRRRL---DHKMVHRGFCAALSKPK-AIRRACNPQE 912
+W + WS CS C G+Q C + ++ + C+ L KP + RAC P
Sbjct: 1054 QWLVSAWSQCSVTCERGTQKRFLKCAEKYVSGKYRELASKKCSHLPKPSLELERACAPLP 1113
Query: 913 C-----------SQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCND 961
C S+ W W C+ +CG G+Q RSV+C+ + +H K
Sbjct: 1114 CPRHPPFAAAGPSRGSWFASPWSQCTASCG-GGVQTRSVQCLAGGRPASGCLLHQK---- 1168
Query: 962 ARPESRRACSRELCP 976
P + AC+ CP
Sbjct: 1169 --PSASLACNTHFCP 1181
Score = 37.0 bits (84), Expect = 0.11
Identities = 28/89 (31%), Positives = 42/89 (47%), Gaps = 17/89 (19%)
Query: 562 GSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQ-----LCSRQDCP 616
GSW A SP+ C+ +CG GV+ R+ QC GGR SG + C+ CP
Sbjct: 1128 GSWFA-SPWSQCTASCGGGVQTRSVQC-----LAGGRPASGCLLHQKPSASLACNTHFCP 1181
Query: 617 DSLADFREEQCRQW----DLYFEHGDAQH 641
+A+ ++ C+ + L +HG H
Sbjct: 1182 --IAEKKDAFCKDYFHWCYLVPQHGMCSH 1208
>gi|38683827 ADAM metallopeptidase with thrombospondin type 1 motif, 7
preproprotein [Homo sapiens]
Length = 1686
Score = 499 bits (1286), Expect = e-141
Identities = 342/1047 (32%), Positives = 491/1047 (46%), Gaps = 76/1047 (7%)
Query: 4 PAGAARRLLCPALLLLLLLLPPPLLPPPPPPANARLAAAADPPGGPLGHGAERILAVPVR 63
P G + R P L LLLLL L P P PA PG A + PVR
Sbjct: 2 PGGPSPRSPAPLLRPLLLLLCA-LAPGAPGPA----------PGRATEGRAALDIVHPVR 50
Query: 64 TDAQGRLVSHVV-SAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDLHL 122
DA G +S+ + A + V RR AP FY + GR+L
Sbjct: 51 VDAGGSFLSYELWPRALRKRDVSVRRDAPA-----------------FYELQYRGRELRF 93
Query: 123 RLRPNARLVAPGATMEWQ--GEKGTTRVEPLLGSCLYVGDVAGLA-EASSVALSNCDGLA 179
L N L+APG E + G G + +C +G+V E A+S CDGL
Sbjct: 94 NLTANQHLLAPGFVSETRRRGGLGRAHIRAHTPACHLLGEVQDPELEGGLAAISACDGLK 153
Query: 180 GLIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRR--PPTSPPLGGPQALDT-GASL-DS 235
G+ ++ E++FIEPL+ A + HVVY+R P G A T G +
Sbjct: 154 GVFQLSNEDYFIEPLDS--APARPGHAQPHVVYKRQAPERLAQRGDSSAPSTCGVQVYPE 211
Query: 236 LDSLSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLM 295
L+S ++ RR + + + +E L+ D +V++HG+ V+ Y+LT+M
Sbjct: 212 LESRRERWEQRQQWRRPRLRRLHQRSVSKEKWVETLVVADAKMVEYHGQPQVESYVLTIM 271
Query: 296 NIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTG 355
N+V ++HD S+G I++ +VR++LL + L + +L++ C+W
Sbjct: 272 NMVAGLFHDPSIGNPIHITIVRLVLLE-DEEEDLKITHHADNTLKSFCKWQKSINMKGDA 330
Query: 356 HDEYHDHAIFLTRQDF-----GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHET 410
H +HD AI LTR+D P G + V GMC P RSC++N + G AF VAHE
Sbjct: 331 HPLHHDTAILLTRKDLCAAMNRPCETLGLSHVAGMCQPHRSCSINEDTGLPLAFTVAHEL 390
Query: 411 GHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYL-HSYDCLLDD 469
GH G++HDG GN C + IM+P + WSRCS+Q ++R+L + LDD
Sbjct: 391 GHSFGIQHDGSGNDCEPVGKRPFIMSPQLLYDAAPLTWSRCSRQYITRFLDRGWGLCLDD 450
Query: 470 PFAH---DWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFC 526
P A D+P++P PG+ Y ++ QCR +G C + C LWCS C
Sbjct: 451 PPAKDIIDFPSVP--PGVLYDVSHQCRLQYGAYSAFCEDMD--NVCHTLWCSVGTT---C 503
Query: 527 KTKKGPPLDGTMCAPGKHCFKGHC--IWLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFR 584
+K +DGT C K C G C + P+ + DG W WS + CSR+CG GV+
Sbjct: 504 HSKLDAAVDGTRCGENKWCLSGECVPVGFRPEAV--DGGWSGWSAWSICSRSCGMGVQSA 561
Query: 585 TRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLADFREEQCRQWDLYFEHGDAQHHWL 644
RQC P P GR C G F+LC+ Q CP FR QC +D G H W+
Sbjct: 562 ERQCTQPTPKYKGRYCVGERKRFRLCNLQACPAGRPSFRHVQCSHFDAMLYKGQL-HTWV 620
Query: 645 PHEHRDAKERCHLYCESRETGEVVSMKRMVHDGTRC-SYKDAFSLCVRGDCRKVGCDGVI 703
P + C L+C ++ V DGT C + + LC+ G C+ VGCD I
Sbjct: 621 PVV--NDVNPCELHCRPANEYFAEKLRDAVVDGTPCYQVRASRDLCINGICKNVGCDFEI 678
Query: 704 GSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSHHL 763
S ED+CGVC G+ S C V GTF + + GY+ + IPAGAR + IQEV ++ L
Sbjct: 679 DSGAMEDRCGVCHGNGSTCHTVSGTFEEA-EGLGYVDVGLIPAGAREIRIQEVAEAANFL 737
Query: 764 AVKNLETGKFILNEENDVDASSKTFIAMGVEWEYRDEDGRETLQTMGPLHGTITVLVIPV 823
A+++ + K+ LN + + +A G + Y E L + GP + + ++
Sbjct: 738 ALRSEDPEKYFLNGGWTIQWNGDYQVA-GTTFTYARRGNWENLTSPGPTKEPVWIQLL-F 795
Query: 824 GDTRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRR 883
++ + Y+Y IH ++ D E V+ W W+ C+ CG G Q C
Sbjct: 796 QESNPGVHYEYTIHREAGGHD-----EVPPPVFSWHYGPWTKCTVTCGRGVQRQNVYCLE 850
Query: 884 RLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCI 943
R V C L +P +R C+ Q C W GEW+ CS +CG G+ R+V CI
Sbjct: 851 R-QAGPVDEEHCDPLGRPDDQQRKCSEQPCPAR-WWAGEWQLCSSSCGPGGLSRRAVLCI 908
Query: 944 QPLHDNTTRSVHAKHCND-ARPESRRACSREL-CPGRWRAGPWSQCSVTCGNGTQERPVL 1001
+ + + ++ C RP + C+R + CP W G WSQCSVTCG GTQ R VL
Sbjct: 909 RSVGLDEQSALEPPACEHLPRPPTETPCNRHVPCPATWAVGNWSQCSVTCGEGTQRRNVL 968
Query: 1002 CRTADDSFGICQEERPETARTCRLGPC 1028
C T D + ++P + TC L C
Sbjct: 969 C-TNDTGVPCDEAQQPASEVTCSLPLC 994
Score = 99.0 bits (245), Expect = 2e-20
Identities = 73/246 (29%), Positives = 91/246 (36%), Gaps = 51/246 (20%)
Query: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPV 917
W WS CS+ CGGGS C D + + C R C Q C
Sbjct: 1466 WHSGNWSKCSRSCGGGSSVRDVQCVDTRDLRPLRPFHCQPGPAKPPAHRPCGAQPCLS-- 1523
Query: 918 WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDA-RPESRRACSRELCP 976
W T W CS+ CG G Q R V C +P C +A RP + R C+ C
Sbjct: 1524 WYTSSWRECSEACGG-GEQQRLVTCPEP-----------GLCEEALRPNTTRPCNTHPCT 1571
Query: 977 GRWRAGPWSQCSVTCGNGTQERPVLCRTA------DDSFGICQEERPETARTCRLGPCPR 1030
+W GPW QCS CG G Q R V C +DS E PE++R C C
Sbjct: 1572 -QWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPESSRPCGTEDC-- 1628
Query: 1031 NISDPSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSI--FCRMEVLSRYCSIPGYNKL 1088
+P P R C+ D+ FC L C +P
Sbjct: 1629 ------------------EPVEPPR-------CERDRLSFGFCETLRLLGRCQLPTIRTQ 1663
Query: 1089 CCKSCN 1094
CC+SC+
Sbjct: 1664 CCRSCS 1669
Score = 98.2 bits (243), Expect = 4e-20
Identities = 58/179 (32%), Positives = 80/179 (44%), Gaps = 17/179 (9%)
Query: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPV 917
W WS CS CG G+ + C D CA +P+ RR C+ + C+
Sbjct: 1415 WQAGNWSECSTTCGLGAVWRPVRCSSGRDED------CAPAGRPQPARR-CHLRPCA--T 1465
Query: 918 WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCPG 977
W +G W CS++CG G VR V+C+ R H + A+P + R C + C
Sbjct: 1466 WHSGNWSKCSRSCG-GGSSVRDVQCVDTRDLRPLRPFHCQP-GPAKPPAHRPCGAQPCLS 1523
Query: 978 RWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQEE-RPETARTCRLGPCPRNISDP 1035
W W +CS CG G Q+R V C G+C+E RP T R C PC + + P
Sbjct: 1524 -WYTSSWRECSEACGGGEQQRLVTCPEP----GLCEEALRPNTTRPCNTHPCTQWVVGP 1577
Score = 31.6 bits (70), Expect = 4.8
Identities = 29/117 (24%), Positives = 44/117 (37%), Gaps = 11/117 (9%)
Query: 857 EWALKKWSPCSKPCGGGSQFTKYGC-RRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQ 915
+W + W CS PCGGG Q C + C + P++ R C ++C +
Sbjct: 1572 QWVVGPWGQCSGPCGGGVQRRLVKCVNTQTGLPEEDSDQCGHEAWPES-SRPCGTEDC-E 1629
Query: 916 PVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSR 972
PV EP C R + ++ L ++ + C P S A SR
Sbjct: 1630 PV------EP--PRCERDRLSFGFCETLRLLGRCQLPTIRTQCCRSCSPPSHGAPSR 1678
>gi|56121815 ADAM metallopeptidase with thrombospondin type 1 motif,
10 preproprotein [Homo sapiens]
Length = 1103
Score = 494 bits (1273), Expect = e-139
Identities = 334/1066 (31%), Positives = 498/1066 (46%), Gaps = 118/1066 (11%)
Query: 107 SHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSCLYVGDVAGLAE 166
S LFY V L L ++RL+A ++E+ +G CLY G + G A
Sbjct: 74 SRLFYKVASPSTHFLLNLTRSSRLLAGHVSVEYWTREGLAWQRAARPHCLYAGHLQGQAS 133
Query: 167 ASSVALSNCDGLAGLIRMEEEEFFIEPLEKG-LAAQEAEQGRVHVVYRRPPTSPPLGGPQ 225
S VA+S C GL GLI +EEE+ IEPL G ++ E+ HVVY+R P
Sbjct: 134 TSHVAISTCGGLHGLIVADEEEYLIEPLHGGPKGSRSPEESGPHVVYKRSSLRHP----- 188
Query: 226 ALDTGASLDS----------LDSL----SRALGVLEEHANSSRRRARRHAADDDYNIEVL 271
LDT + L +L +R LG E +R+ + +E L
Sbjct: 189 HLDTACGVRDEKPWKGRPWWLRTLKPPPARPLGNETERGQPGLKRS----VSRERYVETL 244
Query: 272 LGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIE 331
+ D +V +HG+ V++Y+L +MNIV +++ D SLG+ +N+++ R+ILL+ + +E
Sbjct: 245 VVADKMMVAYHGRRDVEQYVLAIMNIVAKLFQDSSLGSTVNILVTRLILLT--EDQPTLE 302
Query: 332 IGNPS-QSLENVCRWAYLQQKPDTGHDEY-----------HDHAIFLTRQDF-----GPS 374
I + + +SL++ C+W QK H + HD A+ +TR D P
Sbjct: 303 ITHHAGKSLDSFCKW----QKSIVNHSGHGNAIPENGVANHDTAVLITRYDICIYKNKPC 358
Query: 375 GMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVR-LGS 433
G G APV GMC RSC++N + G ++AF +AHE GH GM HDG GN CG +
Sbjct: 359 GTLGLAPVGGMCERERSCSVNEDIGLATAFTIAHEIGHTFGMNHDGVGNSCGARGQDPAK 418
Query: 434 IMAPLVQAAFHRFHWSRCSQQELSRYLHSYD--CLLDDPFAHDWPALPQLPGLHYSMNEQ 491
+MA + + F WS CS+ ++ +L S CL + P D+ PG Y +EQ
Sbjct: 419 LMAAHITMKTNPFVWSSCSRDYITSFLDSGLGLCLNNRPPRQDFVYPTVAPGQAYDADEQ 478
Query: 492 CRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPPLDGTMCAPGK----HCFK 547
CRF G+ C + + C +LWC N C T P +GT+C C+K
Sbjct: 479 CRFQHGVKSRQC---KYGEVCSELWCLSKSNR--CITNSIPAAEGTLCQTHTIDKGWCYK 533
Query: 548 GHCIWLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDF 607
C+ DG+WG W+P+G CSRTCG GV +R CD+P P GG+ C G
Sbjct: 534 RVCVPFGSRPEGVDGAWGPWTPWGDCSRTCGGGVSSSSRHCDSPRPTIGGKYCLGERRRH 593
Query: 608 QLCSRQDCPDSLADFREEQCRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYCESRETGEV 667
+ C+ DCP DFRE QC ++D G + W + K C L C +
Sbjct: 594 RSCNTDDCPPGSQDFREVQCSEFDSIPFRGKF-YKWKTYRGGGVK-ACSLTCLAEGFNFY 651
Query: 668 VSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKG 727
V DGT C D +CV G+C+ VGCD V+GS +EDKC VCGGD S C+ ++G
Sbjct: 652 TERAAAVVDGTPCR-PDTVDICVSGECKHVGCDRVLGSDLREDKCRVCGGDGSACETIEG 710
Query: 728 TFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEENDVDASSKT 787
F+ + GY + IP G+ H+ IQ+++ + HLA+K + + +L E
Sbjct: 711 VFSPASPGAGYEDVVWIPKGSVHIFIQDLNLSLSHLALKGDQ--ESLLLEGLPGTPQPHR 768
Query: 788 FIAMGVEWEYRD-EDGRETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMIHEDSLNVDDN 846
G ++ R D ++L+ +GP++ ++ V+V+ + +L Y++ N
Sbjct: 769 LPLAGTTFQLRQGPDQVQSLEALGPINASLIVMVLARTEL-PALRYRF-----------N 816
Query: 847 NVLEEDSV-VYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIR 905
+ DS+ Y W W+ CS C GGSQ CR +LD V +C+A SK +
Sbjct: 817 APIARDSLPPYSWHYAPWTKCSAQCAGGSQVQAVECRNQLDSSAVAPHYCSAHSKLPKRQ 876
Query: 906 RACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPE 965
RACN + C P WV G W CS++C G++ RSV C + + +++ C RP
Sbjct: 877 RACNTEPC-PPDWVVGNWSLCSRSCD-AGVRSRSVVCQRRVSAAEEKALDDSACPQPRPP 934
Query: 966 SRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGI-----CQEERPETA 1020
AC CP W A WS+C+ +CG G + R VLC++AD + +P
Sbjct: 935 VLEACHGPTCPPEWAALDWSECTPSCGPGLRHRVVLCKSADHRATLPPAHCSPAAKPPAT 994
Query: 1021 RTCRLGPCP-------------------------RNISDPSKKSYVVQWLSRPDP----- 1050
C L CP R S + S+ RP
Sbjct: 995 MRCNLRRCPPARWVAGEWGECSAQCGVGQRQRSVRCTSHTGQASHECTEALRPPTTQQCE 1054
Query: 1051 ---DSPIRKISSKGHCQGDKSIFCRMEVLSRYCSIPGYNKLCCKSC 1093
DSP + +K +C + + ++CS + ++CCK+C
Sbjct: 1055 AKCDSPTPGDGPEECKDVNKVAYCPLVLKFQFCSRAYFRQMCCKTC 1100
>gi|33624896 ADAM metallopeptidase with thrombospondin type 1 motif, 9
preproprotein [Homo sapiens]
Length = 1935
Score = 476 bits (1224), Expect = e-134
Identities = 335/1052 (31%), Positives = 498/1052 (47%), Gaps = 117/1052 (11%)
Query: 54 AERILAVPVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNV 113
+E + P+R +A G V +R R+ +A P+F + S Y +
Sbjct: 46 SEYEIVSPIRVNALGEPFPTNVHFKRTR---RSINSATDPWPAFASSSSSSTSSQAHYRL 102
Query: 114 TVFGRDLHLRLRPNARLVAPGATMEWQGEKGTTRV------EPLLGSCLYVGDVAGLAEA 167
+ FG+ L NA +AP T+ G G + E L C Y G V +E
Sbjct: 103 SAFGQQFLFNLTANAGFIAPLFTVTLLGTPGVNQTKFYSEEEAELKHCFYKGYVNTNSEH 162
Query: 168 SSVALSNCDGLAGLIRMEEEEFFIEPLEK-GLAAQEAEQGRVHVVYRRP-PTSPPLGGPQ 225
++V +S C G+ G R + ++FIEPL+ E EQ + H++YRR P P G
Sbjct: 163 TAV-ISLCSGMLGTFRSHDGDYFIEPLQSMDEQEDEEEQNKPHIIYRRSAPQREPSTGRH 221
Query: 226 ALDTGA-----SLDSLDSLSRALG-------------------VLEEHANSS-------- 253
A DT S D + +R G + N +
Sbjct: 222 ACDTSEHKNRHSKDKKKTRARKWGERINLAGDVAALNSGLATEAFSAYGNKTDNTREKRT 281
Query: 254 RRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINV 313
RR +R + + +EVL+ D+ +V +HG E++Q Y+LTLM+IV IY D S+G IN+
Sbjct: 282 HRRTKRFLSYPRF-VEVLVVADNRMVSYHG-ENLQHYILTLMSIVASIYKDPSIGNLINI 339
Query: 314 VLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDF-- 371
V+V +I++ + I N +L+N C+W + + P H HD A+ LTRQD
Sbjct: 340 VIVNLIVIHNEQDGPSISF-NAQTTLKNFCQWQHSKNSPGGIH---HDTAVLLTRQDICR 395
Query: 372 --GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEV 429
G A + +C P RSC+++ + G S+AF +AHE GHV M HD N+C +E
Sbjct: 396 AHDKCDTLGLAELGTICDPYRSCSISEDSGLSTAFTIAHELGHVFNMPHD-DNNKCKEEG 454
Query: 430 RLGS--IMAPLVQAAFHRFHWSRCSQQELSRYLHSY--DCLLDDPFAHDWPALPQLPGLH 485
+MAP + + + WS+CS++ ++ +L + +CLL++P + +P QLPG+
Sbjct: 455 VKSPQHVMAPTLNFYTNPWMWSKCSRKYITEFLDTGYGECLLNEPESRPYPLPVQLPGIL 514
Query: 486 YSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYF-CKTKKGPPLDGTMCAPGKH 544
Y++N+QC FG G +C C++LWC++ + + C+T+ P DGT C PGKH
Sbjct: 515 YNVNKQCELIFGPGSQVCPYMMQ---CRRLWCNNVNGVHKGCRTQHTPWADGTECEPGKH 571
Query: 545 CFKGHCIWLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLA 604
C G C+ D+ DGSWG+WSPFG+CSRTCG G+K R+C+ P P NGG+ C G
Sbjct: 572 CKYGFCVPKEMDVPVTDGSWGSWSPFGTCSRTCGGGIKTAIRECNRPEPKNGGKYCVGRR 631
Query: 605 YDFQLCSRQDCPDSLADFREEQCRQWDLYFEHGDAQH----------HWLP-HEHRDAKE 653
F+ C+ + C DFR+EQC H D +H W+P + K+
Sbjct: 632 MKFKSCNTEPCLKQKRDFRDEQC-------AHFDGKHFNINGLLPNVRWVPKYSGILMKD 684
Query: 654 RCHLYCESRETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCG 713
RC L+C ++ V DGT C +D +CV+G CR+ GCD V+ S + DKCG
Sbjct: 685 RCKLFCRVAGNTAYYQLRDRVIDGTPCG-QDTNDICVQGLCRQAGCDHVLNSKARRDKCG 743
Query: 714 VCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGA------RHLLIQEVDATSHHLAVKN 767
VCGGDNS CK V GTF + +GY + IPAGA +H E D ++LA+ +
Sbjct: 744 VCGGDNSSCKTVAGTF--NTVHYGYNTVVRIPAGATNIDVRQHSFSGETD-DDNYLALSS 800
Query: 768 LETGKFILNEENDVDASSKTFIAMG---VEWEYRDEDGRETLQTMGPLHGTITVLVIPVG 824
G+F+LN N V +K I +G VE+ E E + + + + + V+ VG
Sbjct: 801 -SKGEFLLN-GNFVVTMAKREIRIGNAVVEYS-GSETAVERINSTDRIEQELLLQVLSVG 857
Query: 825 DTRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYEW-ALKKWSPCSKPCGGGSQFTKYGCRR 883
++ + N +E+ + W + W CSKPC G + K C R
Sbjct: 858 ----------KLYNPDVRYSFNIPIEDKPQQFYWNSHGPWQACSKPC-QGERKRKLVCTR 906
Query: 884 RLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCI 943
D V C L +P I C +C W CS CG G + + C
Sbjct: 907 ESDQLTVSDQRCDRLPQPGHITEPCG-TDCDLR-WHVASRSECSAQCG-LGYRTLDIYCA 963
Query: 944 QPLH-DNTTRSVHAKHCND-ARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVL 1001
+ D T V C+ +P +R CS E G WR W++CS +C GTQ R +
Sbjct: 964 KYSRLDGKTEKVDDGFCSSHPKPSNREKCSGECNTGGWRYSAWTECSKSCDGGTQRRRAI 1023
Query: 1002 C-RTADDSF--GICQEERPETARTCRLGPCPR 1030
C T +D C + T + C PCP+
Sbjct: 1024 CVNTRNDVLDDSKCTHQEKVTIQRCSEFPCPQ 1055
Score = 108 bits (269), Expect = 4e-23
Identities = 65/177 (36%), Positives = 88/177 (49%), Gaps = 11/177 (6%)
Query: 855 VYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECS 914
+Y W ++W C+K CG GS++ K C D+K G +SK R +C+ Q C
Sbjct: 1556 LYTWRAEEWQECTKTCGEGSRYRKVVCVD--DNKNEVHGARCDVSKRPVDRESCSLQPCE 1613
Query: 915 QPVWVTGEWEPCSQTCGRTGMQVRSVRC--IQPLHDNTTRSVHAK-HCNDARPESRRACS 971
VW+TGEW CS TCG+ G + R V C I +N S +C +P S C
Sbjct: 1614 Y-VWITGEWSECSVTCGK-GYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCY 1671
Query: 972 RELCP--GRWRAGPWSQCSVTCGNGTQERPVLCRTADDS-FGICQEE-RPETARTCR 1024
CP WR G W CSV+CG G +R V C T +D +C + +PE +TCR
Sbjct: 1672 LRDCPVSATWRVGNWGSCSVSCGVGVMQRSVQCLTNEDQPSHLCHTDLKPEERKTCR 1728
Score = 104 bits (260), Expect = 4e-22
Identities = 60/184 (32%), Positives = 84/184 (45%), Gaps = 18/184 (9%)
Query: 857 EWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQP 916
+W WS CS CG G Q GC+ HK+ C ++P++ R C C
Sbjct: 1500 KWKAGAWSQCSVSCGRGVQQRHVGCQIGT-HKIARETECNPYTRPES-ERDCQGPRCPLY 1557
Query: 917 VWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCN-DARPESRRACSRELC 975
W EW+ C++TCG G + R V C+ D+ VH C+ RP R +CS + C
Sbjct: 1558 TWRAEEWQECTKTCGE-GSRYRKVVCV----DDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
Query: 976 PGRWRAGPWSQCSVTCGNGTQERPVLCR---TADDSFGI-------CQEERPETARTCRL 1025
W G WS+CSVTCG G ++R V C T +++ C +P + C L
Sbjct: 1613 EYVWITGEWSECSVTCGKGYKQRLVSCSEIYTGKENYEYSYQTTINCPGTQPPSVHPCYL 1672
Query: 1026 GPCP 1029
CP
Sbjct: 1673 RDCP 1676
Score = 97.1 bits (240), Expect = 9e-20
Identities = 62/179 (34%), Positives = 80/179 (44%), Gaps = 19/179 (10%)
Query: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPV 917
W+ WS CS CG G + C + D + +C L+KP R+ C C P
Sbjct: 1445 WSTGPWSSCSVSCGRGHKQRNVYCMAK-DGSHLESDYCKHLAKPHGHRK-CRGGRC--PK 1500
Query: 918 WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCND-ARPESRRACSRELCP 976
W G W CS +CGR G+Q R V C T + CN RPES R C CP
Sbjct: 1501 WKAGAWSQCSVSCGR-GVQQRHVGC----QIGTHKIARETECNPYTRPESERDCQGPRCP 1555
Query: 977 -GRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQ------EERPETARTCRLGPC 1028
WRA W +C+ TCG G++ R V+C DD+ +RP +C L PC
Sbjct: 1556 LYTWRAEEWQECTKTCGEGSRYRKVVC--VDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
Score = 92.4 bits (228), Expect = 2e-18
Identities = 60/180 (33%), Positives = 76/180 (42%), Gaps = 16/180 (8%)
Query: 857 EWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQP 916
+W W CS C GGSQ C+ D C KP +RAC C P
Sbjct: 1331 QWRTGPWGACSSTCAGGSQRRVVVCQ---DENGYTANDCVERIKPDE-QRACESGPC--P 1384
Query: 917 VWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCP 976
W G W C++ CG G++ R V C + N R +P R C+ CP
Sbjct: 1385 QWAYGNWGECTKLCGG-GIRTRLVVCQR---SNGERFPDLSCEILDKPPDREQCNTHACP 1440
Query: 977 --GRWRAGPWSQCSVTCGNGTQERPVLCRTADDSF---GICQE-ERPETARTCRLGPCPR 1030
W GPWS CSV+CG G ++R V C D S C+ +P R CR G CP+
Sbjct: 1441 HDAAWSTGPWSSCSVSCGRGHKQRNVYCMAKDGSHLESDYCKHLAKPHGHRKCRGGRCPK 1500
Score = 90.9 bits (224), Expect = 7e-18
Identities = 67/219 (30%), Positives = 88/219 (40%), Gaps = 27/219 (12%)
Query: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPV 917
W W CS CG G Q C +V C A ++P + C C P
Sbjct: 1111 WQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQD-CELPSCHPPP 1169
Query: 918 ----------------WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCND 961
W G W PCS TCG+ G ++R V C +N + + +
Sbjct: 1170 AAPETRRSTYSAPRTQWRFGSWTPCSATCGK-GTRMRYVSCRD---ENGSVADESACATL 1225
Query: 962 ARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSF---GIC-QEERP 1017
RP ++ CS C G+W+A WS CSVTCG G R V+C D C Q+ P
Sbjct: 1226 PRPVAKEECSVTPC-GQWKALDWSSCSVTCGQGRATRQVMCVNYSDHVIDRSECDQDYIP 1284
Query: 1018 ETARTCRLGPCPRNISDPSKKSYVVQWLS-RPDPDSPIR 1055
ET + C + PCP+ D + Q RP SP R
Sbjct: 1285 ETDQDCSMSPCPQRTPDSGLAQHPFQNEDYRPRSASPSR 1323
Score = 88.2 bits (217), Expect = 4e-17
Identities = 63/197 (31%), Positives = 90/197 (45%), Gaps = 37/197 (18%)
Query: 857 EWALKKWSPCSKPCGGGSQFTKYGCR---RRLDHKMVHRGFCAALSKPKAIRRACNPQEC 913
+W WS C CG G + + C+ RL+ +M C +KP +++ C EC
Sbjct: 1055 QWKSGDWSECLVTCGKGHKHRQVWCQFGEDRLNDRM-----CDPETKPTSMQ-TCQQPEC 1108
Query: 914 SQPVWVTGEWEPCSQTCGRTGMQVRSVRCI-----QPLHDN----TTRSVHAKHCN---- 960
+ W G W CS TCG+ G Q+R+V+CI + DN TR + C
Sbjct: 1109 AS--WQAGPWGQCSVTCGQ-GYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELPSC 1165
Query: 961 ---DARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQEE-- 1015
A PE+RR+ + +WR G W+ CS TCG GT+ R V CR D++ + E
Sbjct: 1166 HPPPAAPETRRS-TYSAPRTQWRFGSWTPCSATCGKGTRMRYVSCR--DENGSVADESAC 1222
Query: 1016 ----RPETARTCRLGPC 1028
RP C + PC
Sbjct: 1223 ATLPRPVAKEECSVTPC 1239
Score = 83.2 bits (204), Expect = 1e-15
Identities = 58/182 (31%), Positives = 79/182 (43%), Gaps = 28/182 (15%)
Query: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRL-----DHKMVHRGFCAALSKPKAIRRACNPQE 912
W W+ CSK C GG+Q + C D K H+ K + C+
Sbjct: 1001 WRYSAWTECSKSCDGGTQRRRAICVNTRNDVLDDSKCTHQ--------EKVTIQRCSEFP 1052
Query: 913 CSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCN-DARPESRRACS 971
C P W +G+W C TCG+ G + R V C Q D ++ + C+ + +P S + C
Sbjct: 1053 C--PQWKSGDWSECLVTCGK-GHKHRQVWC-QFGEDR----LNDRMCDPETKPTSMQTCQ 1104
Query: 972 RELCPGRWRAGPWSQCSVTCGNGTQERPVLC-----RTADDSFGICQEERPETARTCRLG 1026
+ C W+AGPW QCSVTCG G Q R V C + D RP + C L
Sbjct: 1105 QPECAS-WQAGPWGQCSVTCGQGYQLRAVKCIIGTYMSVVDDNDCNAATRPTDTQDCELP 1163
Query: 1027 PC 1028
C
Sbjct: 1164 SC 1165
Score = 70.9 bits (172), Expect = 7e-12
Identities = 53/181 (29%), Positives = 71/181 (39%), Gaps = 43/181 (23%)
Query: 857 EWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQP 916
+W WS CS CG G + C DH ++ R C P+ Q+CS
Sbjct: 1241 QWKALDWSSCSVTCGQGRATRQVMCVNYSDH-VIDRSECDQDYIPE------TDQDCSM- 1292
Query: 917 VWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCP 976
PC Q +G+ + H D RP S +
Sbjct: 1293 -------SPCPQRTPDSGL-----------------AQHPFQNEDYRPRSASPSRTHVLG 1328
Query: 977 G-RWRAGPWSQCSVTCGNGTQERPVLCR-----TADDSFGICQEE-RPETARTCRLGPCP 1029
G +WR GPW CS TC G+Q R V+C+ TA+D C E +P+ R C GPCP
Sbjct: 1329 GNQWRTGPWGACSSTCAGGSQRRVVVCQDENGYTAND----CVERIKPDEQRACESGPCP 1384
Query: 1030 R 1030
+
Sbjct: 1385 Q 1385
Score = 31.2 bits (69), Expect = 6.3
Identities = 19/67 (28%), Positives = 27/67 (40%), Gaps = 12/67 (17%)
Query: 564 WGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLADFR 623
+G+W+P CS TCG G + R C R +G D C+ P + +
Sbjct: 1188 FGSWTP---CSATCGKGTRMRYVSC---------RDENGSVADESACATLPRPVAKEECS 1235
Query: 624 EEQCRQW 630
C QW
Sbjct: 1236 VTPCGQW 1242
Score = 31.2 bits (69), Expect = 6.3
Identities = 17/46 (36%), Positives = 24/46 (52%), Gaps = 3/46 (6%)
Query: 573 CSRTCGTGVKFRTRQC--DNPHPANGGR-TCSGLAYDFQLCSRQDC 615
C++TCG G ++R C DN + +G R S D + CS Q C
Sbjct: 1567 CTKTCGEGSRYRKVVCVDDNKNEVHGARCDVSKRPVDRESCSLQPC 1612
>gi|51558724 ADAM metallopeptidase with thrombospondin type 1 motif,
12 preproprotein [Homo sapiens]
Length = 1594
Score = 459 bits (1180), Expect = e-129
Identities = 306/1000 (30%), Positives = 483/1000 (48%), Gaps = 72/1000 (7%)
Query: 61 PVRTDAQGRLVSHVVSAATSRAGVRARRAAPVRTPSFPGGNEEEPGSHLFYNVTVFGRDL 120
PVR DA G +S+ G+ + R G + ++Y ++ +DL
Sbjct: 57 PVRVDASGHFLSY---------GLHYPITSSRRKRDLDGSED-----WVYYRISHEEKDL 102
Query: 121 HLRLRPNARLVAPGATMEWQ-GEKGTTRVEP-------LLGSCLYVGDVAGLAEASSVAL 172
L N ++ ME + G ++ L G+ L G G A AL
Sbjct: 103 FFNLTVNQGFLSNSYIMEKRYGNLSHVKMMASSAPLCHLSGTVLQQGTRVGTA-----AL 157
Query: 173 SNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRR---PPTSPPLGGPQALDT 229
S C GL G ++ +FFIEP++K + H+VYRR P T P G L
Sbjct: 158 SACHGLTGFFQLPHGDFFIEPVKKHPLVEGGYHP--HIVYRRQKVPETKEPTCG---LKD 212
Query: 230 GASLDSLDSLSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQK 289
++ L R E H SR +RR + + + +E L+ D ++++HG E+V+
Sbjct: 213 SVNISQKQELWREKW--ERHNLPSRSLSRRSISKERW-VETLVVADTKMIEYHGSENVES 269
Query: 290 YLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQ 349
Y+LT+MN+V ++H+ S+G I++V+VR+ILL + L + + ++L + C+W
Sbjct: 270 YILTIMNMVTGLFHNPSIGNAIHIVVVRLILLEE-EEQGLKIVHHAEKTLSSFCKWQKSI 328
Query: 350 QKPDTGHDEYHDHAIFLTRQDF-----GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAF 404
+ +HD A+ LTR+D P G + ++GMC P RSC +N + G AF
Sbjct: 329 NPKSDLNPVHHDVAVLLTRKDICAGFNRPCETLGLSHLSGMCQPHRSCNINEDSGLPLAF 388
Query: 405 VVAHETGHVLGMEHDGQGNRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSY- 463
+AHE GH G++HDG+ N C R IM+ +Q WS+CS++ ++R+L
Sbjct: 389 TIAHELGHSFGIQHDGKENDCEPVGRHPYIMSRQLQYDPTPLTWSKCSEEYITRFLDRGW 448
Query: 464 -DCLLDDPFAHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDN 522
CL D P + PG+ Y ++ QC+ +G C C+ LWCS
Sbjct: 449 GFCLDDIPKKKGLKSKVIAPGVIYDVHHQCQLQYGPNATFCQEVENV--CQTLWCSVKG- 505
Query: 523 PYFCKTKKGPPLDGTMCAPGKHCFKGHCIWLTPDILKRDGSWGAWSPFGSCSRTCGTGVK 582
FC++K DGT C K C G CI + G WG WSP+ CSRTCG GV+
Sbjct: 506 --FCRSKLDAAADGTQCGEKKWCMAGKCITVGKKPESIPGGWGRWSPWSHCSRTCGAGVQ 563
Query: 583 FRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLADFREEQCRQWDLYFEHGDAQHH 642
R C+NP P GG+ C+G ++LC+ C FR+ QC ++D + + +H
Sbjct: 564 SAERLCNNPEPKFGGKYCTGERKRYRLCNVHPCRSEAPTFRQMQCSEFDT-VPYKNELYH 622
Query: 643 WLPHEHRDAKERCHLYCESRETGEVVSMKRMVHDGTRC-SYKDAFSLCVRGDCRKVGCDG 701
W P + C LYC + M V DGT C ++ ++C+ G C+ VGCD
Sbjct: 623 WFP--IFNPAHPCELYCRPIDGQFSEKMLDAVIDGTPCFEGGNSRNVCINGICKMVGCDY 680
Query: 702 VIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSH 761
I S+ ED+CGVC GD S C+ V+ F + + GY+ + IP GAR + + E++ +
Sbjct: 681 EIDSNATEDRCGVCLGDGSSCQTVRKMF-KQKEGSGYVDIGLIPKGARDIRVMEIEGAGN 739
Query: 762 HLAVKNLETGKFILNEENDVDASSKTFIAMGVEWEYRDEDGRETLQTMGPLHGTITVLVI 821
LA+++ + K+ LN + + +A G ++Y + E L GP + ++ + ++
Sbjct: 740 FLAIRSEDPEKYYLNGGFIIQWNGNYKLA-GTVFQYDRKGDLEKLMATGPTNESVWIQLL 798
Query: 822 PVGDTRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGC 881
T + Y+Y I +D L DN+V ++ +Y W W+ CS CG G + C
Sbjct: 799 -FQVTNPGIKYEYTIQKDGL---DNDVEQQ---MYFWQYGHWTECSVTCGTGIRRQTAHC 851
Query: 882 RRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVR 941
++ MV FC ++P ++ C+ + C P W GEWE CS TCG G + R+V
Sbjct: 852 IKK-GRGMVKATFCDPETQPNGRQKKCHEKAC-PPRWWAGEWEACSATCGPHGEKKRTVL 909
Query: 942 CIQPLHDNTTRSVHAKHCNDARPESRRACSRE-LCPGRWRAGPWSQCSVTCGNGTQERPV 1000
CIQ + + + +P++ +C+R+ LCP W G WS+CSV+CG G + R V
Sbjct: 910 CIQTMVSDEQALPPTDCQHLLKPKTLLSCNRDILCPSDWTVGNWSECSVSCGGGVRIRSV 969
Query: 1001 LC-RTADDSFGICQEERPETARTCRLGPCP--RNISDPSK 1037
C + D+ + + +P + C L CP R + P+K
Sbjct: 970 TCAKNHDEPCDVTR--KPNSRALCGLQQCPSSRRVLKPNK 1007
Score = 103 bits (258), Expect = 8e-22
Identities = 75/288 (26%), Positives = 113/288 (39%), Gaps = 51/288 (17%)
Query: 841 LNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSK 900
LN + L W + WS CS CG G+ + + C ++D CAA+ +
Sbjct: 1300 LNASNYKQLTNGHGSAHWIVGNWSECSTTCGLGAYWRRVECSTQMDSD------CAAIQR 1353
Query: 901 PKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCN 960
P +R C+ + C+ W G W CS+ C G ++R ++C+ R H +
Sbjct: 1354 PDPAKR-CHLRPCAG--WKVGNWSKCSRNCSG-GFKIREIQCVDSRDHRNLRPFHCQFLA 1409
Query: 961 DARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQ-EERPET 1019
P +C+ E C W+ PWSQCS +CG G QER V C G+C +RP +
Sbjct: 1410 GIPPPLSMSCNPEPCEA-WQVEPWSQCSRSCGGGVQERGVFC-----PGGLCDWTKRPTS 1463
Query: 1020 ARTCRLGPC--------------------PRNI----SDPSKKSYVVQWLSRPDPDSPIR 1055
+C C R + S+ +K Q L P P
Sbjct: 1464 TMSCNEHLCCHWATGNWDLCSTSCGGGFQKRTVQCVPSEGNKTEDQDQCLCDHKPRPPEF 1523
Query: 1056 KISSKGHCQGDKSIFCRMEVLS----------RYCSIPGYNKLCCKSC 1093
K ++ C+ + C + LS + CS+P CC SC
Sbjct: 1524 KKCNQQACKKSADLLCTKDKLSASFCQTLKAMKKCSVPTVRAECCFSC 1571
>gi|124430557 a disintegrin-like and metalloprotease with
thrombospondin type 1 motifs 20 [Homo sapiens]
Length = 1910
Score = 454 bits (1168), Expect = e-127
Identities = 310/979 (31%), Positives = 463/979 (47%), Gaps = 95/979 (9%)
Query: 111 YNVTVFGRDLHLRLRPNARLVAPGATM---------EWQGEKGTTRVEPLLGSCLYVGDV 161
Y T +G+ L L +A +A G T W+ + G + L C Y G V
Sbjct: 80 YRFTAYGQLFQLNLTADASFLAAGYTEVHLGTPERGAWESDAGPSD----LRHCFYRGQV 135
Query: 162 AGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQG--RVHVVYRRPPTSP 219
+ +V +S C GL G + + E+F+EP+ K E E G + H++YR+ +
Sbjct: 136 NSQEDYKAV-VSLCGGLTGTFKGQNGEYFLEPIMKA-DGNEYEDGHNKPHLIYRQDLNNS 193
Query: 220 PL--------GGPQALDTGASLDSLDSLSRALGVLEEHA------NSSRRRARRHAADDD 265
L Q +T + +++ L V++E N + RRH+
Sbjct: 194 FLQTLKYCSVSESQIKETSLPFHTYSNMNEDLNVMKERVLGHTSKNVPLKDERRHSRKKR 253
Query: 266 Y-----NIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIIL 320
IE+++ D VV HG ++Q Y+LTLM+IV IY D S+G I++V+V++++
Sbjct: 254 LISYPRYIEIMVTADAKVVSAHGS-NLQNYILTLMSIVATIYKDPSIGNLIHIVVVKLVM 312
Query: 321 LSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPS----GM 376
+ + +I + +L+N C W Q D H +HD A+ +TR+D S M
Sbjct: 313 IHREEEGPVINFDGAT-TLKNFCSWQQTQNDLDDVHPSHHDTAVLITREDICSSKEKCNM 371
Query: 377 QGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGD-EVRLGSIM 435
G + + +C P++SC +N E G SAF +AHE GH LG++HD RC + +V +M
Sbjct: 372 LGLSYLGTICDPLQSCFINEEKGLISAFTIAHELGHTLGVQHD-DNPRCKEMKVTKYHVM 430
Query: 436 APLVQAAFHRFHWSRCSQQELSRYLHSY--DCLLDDPFAHDWPALPQLPGLHYSMNEQCR 493
AP + + WS CS++ ++ +L + +CLLD P + +LPG Y N+QC
Sbjct: 431 APALSFHMSPWSWSNCSRKYVTEFLDTGYGECLLDKPDEEIYNLPSELPGSRYDGNKQCE 490
Query: 494 FDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYF-CKTKKGPPLDGTMCAPGKHCFKGHCIW 552
FG G MC C LWC+ + + C T+ PP DGT C PG HC G C+
Sbjct: 491 LAFGPGSQMCPHINI---CMHLWCTSTEKLHKGCFTQHVPPADGTDCGPGMHCRHGLCVN 547
Query: 553 LTPDILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSR 612
+ +G WG W P+ SCSRTCG G++ TR+C+ P P NGG C G F+ C+
Sbjct: 548 KETETRPVNGEWGPWEPYSSCSRTCGGGIESATRRCNRPEPRNGGNYCVGRRMKFRSCNT 607
Query: 613 QDCPDSLADFREEQCRQWDLYFEHGD-----AQHHWLP-HEHRDAKERCHLYCESRETGE 666
CP DFRE+QC D +H D + WLP + K+RC LYC+ T
Sbjct: 608 DSCPKGTQDFREKQCS--DFNGKHLDISGIPSNVRWLPRYSGIGTKDRCKLYCQVAGTNY 665
Query: 667 VVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVK 726
+K MV DGT C + +CV+G C GCD V+ SS + DKCGVCGGDNS CK +
Sbjct: 666 FYLLKDMVEDGTPCG-TETHDICVQGQCMAAGCDHVLNSSAKIDKCGVCGGDNSSCKTIT 724
Query: 727 GTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSH----HLAVKNLETGKFILNEENDVD 782
G F S +GY + +IPAGA ++ I++ + +LA+ + E G F+ N +
Sbjct: 725 GVFNSS--HYGYNVVVKIPAGATNVDIRQYSYSGQPDDSYLALSDAE-GNFLFNGNFLLS 781
Query: 783 ASSKTFIAMGVEW--EYRDEDGR-ETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMIHED 839
S K G EY + E + + + + V+ VG+ ++
Sbjct: 782 TSKKEINVQGTRTVIEYSGSNNAVERINSTNRQEKELILQVLCVGN----------LYNP 831
Query: 840 SLNVDDNNVLEEDSVVYEW-ALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAAL 898
++ N LEE S ++ W W C+K C G Q C + DH +V C L
Sbjct: 832 DVHYSFNIPLEERSDMFTWDPYGPWEGCTKMC-QGLQRRNITCIHKSDHSVVSDKECDHL 890
Query: 899 SKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQ-PLHDNTTRSVHAK 957
P + ++CN +C V G+ E CS CG+ G + + C++ +H+ T V
Sbjct: 891 PLPSFVTQSCN-TDCELRWHVIGKSE-CSSQCGQ-GYRTLDIHCMKYSIHEGQTVQVDDH 947
Query: 958 HCND-ARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLC------RTADDSFG 1010
+C D +P ++ C RW WSQCS +CG G + R C R AD+
Sbjct: 948 YCGDQLKPPTQELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESYCMNNFGHRLADNE-- 1005
Query: 1011 ICQEERPETARTCRLGPCP 1029
CQE T C CP
Sbjct: 1006 -CQELSRVTRENCNEFSCP 1023
Score = 100 bits (250), Expect = 6e-21
Identities = 70/217 (32%), Positives = 93/217 (42%), Gaps = 36/217 (16%)
Query: 833 KYMIHE-DSLNVDDN-----------NVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYG 880
KY IHE ++ VDD+ + + V W +WS CS+ CGGG + +
Sbjct: 933 KYSIHEGQTVQVDDHYCGDQLKPPTQELCHGNCVFTRWHYSEWSQCSRSCGGGERSRESY 992
Query: 881 CRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSV 940
C H++ C LS+ R CN C P W EW C TCG+ G + R V
Sbjct: 993 CMNNFGHRLADNE-CQELSR--VTRENCNEFSC--PSWAASEWSECLVTCGK-GTKQRQV 1046
Query: 941 RC---IQPLHDNTTRSVHAKHCNDA-RPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQ 996
C + L D CN + +PES C C W+ GPW C+ TCG+G Q
Sbjct: 1047 WCQLNVDHLSDG--------FCNSSTKPESLSPCELHTC-ASWQVGPWGPCTTTCGHGYQ 1097
Query: 997 ERPVLCRTADDSFGI----CQE-ERPETARTCRLGPC 1028
R V C S + C E RP ++C L PC
Sbjct: 1098 MRDVKCVNELASAVLEDTECHEASRPSDRQSCVLTPC 1134
Score = 100 bits (250), Expect = 6e-21
Identities = 57/169 (33%), Positives = 83/169 (49%), Gaps = 28/169 (16%)
Query: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPV 917
WA +WS C CG G++ + C+ +DH + GFC + +KP+++ C C+
Sbjct: 1025 WAASEWSECLVTCGKGTKQRQVWCQLNVDH--LSDGFCNSSTKPESLS-PCELHTCAS-- 1079
Query: 918 WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDA-RPESRRACSRELCP 976
W G W PC+ TCG G Q+R V+C+ L + + C++A RP R++C C
Sbjct: 1080 WQVGPWGPCTTTCGH-GYQMRDVKCVNEL---ASAVLEDTECHEASRPSDRQSCVLTPCS 1135
Query: 977 ------------------GRWRAGPWSQCSVTCGNGTQERPVLCRTADD 1007
+WR G W+ CSV+CG GTQ R V CR A D
Sbjct: 1136 FISKLETALLPTVLIKKMAQWRHGSWTPCSVSCGRGTQARYVSCRDALD 1184
Score = 95.9 bits (237), Expect = 2e-19
Identities = 63/221 (28%), Positives = 88/221 (39%), Gaps = 61/221 (27%)
Query: 857 EWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQP 916
+W W+PCS CG G+Q CR LD ++ +CA L +P I P C +
Sbjct: 1155 QWRHGSWTPCSVSCGRGTQARYVSCRDALD-RIADESYCAHLPRPAEIWDCFTP--CGE- 1210
Query: 917 VWVTGEWEPCSQTCGRTGMQVRSVRCI---QPLHDNTTRSVHAKHCN-DARPESRRACSR 972
W G+W PCS +CG G R V C+ QP+ +N +C+ + RP + CS
Sbjct: 1211 -WQAGDWSPCSASCGH-GKTTRQVLCMNYHQPIDEN--------YCDPEVRPLMEQECSL 1260
Query: 973 ELCP-----------------------------------------GRWRAGPWSQCSVTC 991
CP +WR GPW CS +C
Sbjct: 1261 AACPPAHSHFPSSPVQPSYYLSTNLPLTQKLEDNENQVVHPSVRGNQWRTGPWGSCSSSC 1320
Query: 992 GNGTQERPVLCRTAD-DSFGICQ-EERPETARTCRLGPCPR 1030
G Q R V+C+ + S C +P + C GPCP+
Sbjct: 1321 SGGLQHRAVVCQDENGQSASYCDAASKPPELQQCGPGPCPQ 1361
Score = 95.5 bits (236), Expect = 3e-19
Identities = 64/200 (32%), Positives = 86/200 (43%), Gaps = 26/200 (13%)
Query: 841 LNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSK 900
L ++N V+ +W W CS C GG Q C+ D +C A SK
Sbjct: 1291 LEDNENQVVHPSVRGNQWRTGPWGSCSSSCSGGLQHRAVVCQ---DENGQSASYCDAASK 1347
Query: 901 PKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQP----LHDNTTRSVHA 956
P +++ C P C P W G W CSQTCG G++ R V C P L D+ V+
Sbjct: 1348 PPELQQ-CGPGPC--PQWNYGNWGECSQTCG-GGIKSRLVICQFPNGQILEDHNCEIVN- 1402
Query: 957 KHCNDARPESRRACSRELCPG--RWRAGPWSQCSVTCGNGTQERPVLC-----RTADDSF 1009
+P S C CP W PW+ CS +CG G + R V C R +D+
Sbjct: 1403 ------KPPSVIQCHMHACPADVSWHQEPWTSCSASCGKGRKYREVFCIDQFQRKLEDT- 1455
Query: 1010 GICQEERPETARTCRLGPCP 1029
Q ++P T + CR CP
Sbjct: 1456 NCSQVQKPPTHKACRSVRCP 1475
Score = 89.4 bits (220), Expect = 2e-17
Identities = 53/174 (30%), Positives = 85/174 (48%), Gaps = 11/174 (6%)
Query: 857 EWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQP 916
+W W CS+ CGGG + C+ + +++ C ++KP ++ + C+ C
Sbjct: 1361 QWNYGNWGECSQTCGGGIKSRLVICQFP-NGQILEDHNCEIVNKPPSVIQ-CHMHACPAD 1418
Query: 917 V-WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDA-RPESRRACSREL 974
V W W CS +CG+ G + R V CI D R + +C+ +P + +AC
Sbjct: 1419 VSWHQEPWTSCSASCGK-GRKYREVFCI----DQFQRKLEDTNCSQVQKPPTHKACRSVR 1473
Query: 975 CPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQEERPETARTCRLGPC 1028
CP W+A W++CSVTCG+G Q+R V CR + +E ++ R C C
Sbjct: 1474 CPS-WKANSWNECSVTCGSGVQQRDVYCRLKGVG-QVVEEMCDQSTRPCSQRRC 1525
Score = 85.5 bits (210), Expect = 3e-16
Identities = 61/194 (31%), Positives = 78/194 (40%), Gaps = 31/194 (15%)
Query: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECS--- 914
W + W PC+ CG G Q C L ++ C S+P R++C CS
Sbjct: 1080 WQVGPWGPCTTTCGHGYQMRDVKCVNELASAVLEDTECHEASRPSD-RQSCVLTPCSFIS 1138
Query: 915 --------------QPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCN 960
W G W PCS +CGR G Q R V C L D + H
Sbjct: 1139 KLETALLPTVLIKKMAQWRHGSWTPCSVSCGR-GTQARYVSCRDAL-DRIADESYCAHL- 1195
Query: 961 DARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLC----RTADDSFGICQEE- 1015
RP C G W+AG WS CS +CG+G R VLC + D+++ C E
Sbjct: 1196 -PRPAEIWDCFTPC--GEWQAGDWSPCSASCGHGKTTRQVLCMNYHQPIDENY--CDPEV 1250
Query: 1016 RPETARTCRLGPCP 1029
RP + C L CP
Sbjct: 1251 RPLMEQECSLAACP 1264
Score = 49.7 bits (117), Expect = 2e-05
Identities = 55/237 (23%), Positives = 83/237 (35%), Gaps = 70/237 (29%)
Query: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPV 917
W W+ CS CG G Q CR + ++V C ++P + RR C Q+C Q
Sbjct: 1477 WKANSWNECSVTCGSGVQQRDVYCRLKGVGQVVEE-MCDQSTRPCSQRR-CWSQDCVQHK 1534
Query: 918 WVTGEWEPCSQTCGR---------TGMQVRSVRCIQPLHDNTTRSVHAK----------- 957
+ CS +C R T Q+R V I +++++T S+ +K
Sbjct: 1535 GMERGRLNCSTSCERKDSHQRMECTDNQIRQVNEI--VYNSSTISLTSKNCRNPPCNYIV 1592
Query: 958 ---------------------HCNDARPESRRACSR------ELCP-------------- 976
+C + + R + CP
Sbjct: 1593 VTADSSQCANNCGFSYRQRITYCTEIPSTKKHKLHRLRPIVYQECPVVPSSQVYQCINSC 1652
Query: 977 ---GRWRAGPWSQCSVTCGNGTQERPVLCRTADD-SFGICQEE-RPETARTCRLGPC 1028
W+ G WS+CSVTCG G +R V C T S +C +P + C C
Sbjct: 1653 LHLATWKVGKWSKCSVTCGIGIMKRQVKCITKHGLSSDLCLNHLKPGAQKKCYANDC 1709
>gi|110611170 ADAM metallopeptidase with thrombospondin type 1 motif,
17 preproprotein [Homo sapiens]
Length = 1095
Score = 446 bits (1148), Expect = e-125
Identities = 330/1033 (31%), Positives = 462/1033 (44%), Gaps = 107/1033 (10%)
Query: 27 LLPPPPPPANARLAAAADPPGGPLGHGA---ERILAVPVRTDAQGRLVSHVVSAATSRAG 83
LLPP P L DP G +G A E +L VR D V A
Sbjct: 6 LLPPLVLPVLLLLVWGLDP-GTAVGDAAADVEVVLPWRVRPDD--------VHLPPLPAA 56
Query: 84 VRARRAAPVRTPSFPGGNEEEPGSH-LFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGE 142
RR RTP P PG L ++ FGRDL+L+LR + R ++ G +E G
Sbjct: 57 PGPRRRRRPRTP--PAAPRARPGERALLLHLPAFGRDLYLQLRRDLRFLSRGFEVEEAGA 114
Query: 143 KGTTRVEPLLGSCLYVGDVAGLAEASSVALSNCD---GLAGLIRMEEEEFFIEPLEKGLA 199
R P C Y G V G S V+LS C GL GLI++ +E+ I+PL
Sbjct: 115 -ARRRGRPA-ELCFYSGRVLG-HPGSLVSLSACGAAGGLVGLIQLGQEQVLIQPLNN--- 168
Query: 200 AQEAEQGRVHVVYRR----PPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRR 255
+Q GR H++ R+ P S P+ L + + R E N+ R
Sbjct: 169 SQGPFSGREHLIRRKWSLTPSPSAEAQRPEQLCKVLTEKKKPTWGRPSRDWRERRNAIRL 228
Query: 256 RARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVL 315
+ ++ +E L+ D +VQ+HG E Q+++LT+MN+V ++ +SLG IN+ +
Sbjct: 229 TS-------EHTVETLVVADADMVQYHGAEAAQRFILTVMNMVYNMFQHQSLGIKINIQV 281
Query: 316 VRIILLSYGKSMSLIEIGNPSQ-SLENVCRWA--------YLQQKPDTGHDE---YHDHA 363
+++LL + + + IG+ + SLE+ C W YL G + D A
Sbjct: 282 TKLVLLR--QRPAKLSIGHHGERSLESFCHWQNEEYGGARYLGNNQVPGGKDDPPLVDAA 339
Query: 364 IFLTRQDF-----GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEH 418
+F+TR DF P G A + G+C R C L ++G + AF +AHE GH LGM H
Sbjct: 340 VFVTRTDFCVHKDEPCDTVGIAYLGGVCSAKRKCVLAEDNGLNLAFTIAHELGHNLGMNH 399
Query: 419 DGQGNRCGDEVRLGSIMAPLVQAAFHR-FHWSRCSQQELSRYLHSY--DCLL-DDPFAHD 474
D + C + S V+ WS CS+ +L +L S CLL DP +
Sbjct: 400 DDDHSSCAGRSHIMS--GEWVKGRNPSDLSWSSCSRDDLENFLKSKVSTCLLVTDPRSQH 457
Query: 475 WPALP-QLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGPP 533
LP +LPG+HYS NEQC+ FG+ C C LWC + CKTK PP
Sbjct: 458 TVRLPHKLPGMHYSANEQCQILFGMNATFCRNMEHL-MCAGLWCL-VEGDTSCKTKLDPP 515
Query: 534 LDGTMCAPGKHCFKGHCIWLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHP 593
LDGT C K C G C+ TP DG W W + CSRTCGTG +FR R+CDNP P
Sbjct: 516 LDGTECGADKWCRAGECVSKTPIPEHVDGDWSPWGAWSMCSRTCGTGARFRQRKCDNPPP 575
Query: 594 ANGGRTCSGLAYDFQLCSRQDCPDSLADFREEQCRQWDLYFEHGDAQHHWLPHEHRDAKE 653
GG C G + + +C CP L FR++QC+ D + L D K
Sbjct: 576 GPGGTHCPGASVEHAVCENLPCPKGLPSFRDQQCQAHD---RLSPKKKGLLTAVVVDDKP 632
Query: 654 RCHLYCESRETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCG 713
C LYC + + V DGT C + LCV G C+K+GCDG+IGS+ +ED+CG
Sbjct: 633 -CELYCSPLGKESPLLVADRVLDGTPCGPYET-DLCVHGKCQKIGCDGIIGSAAKEDRCG 690
Query: 714 VCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKF 773
VC GD C +VKG F SH ++GK
Sbjct: 691 VCSGDGKTCHLVKGDF------------------------------SHARGTALKDSGKG 720
Query: 774 ILNEENDVDASSKTFIAMGVEWEYRDEDGRETLQTMGPLHGTITVLVIPVGDTRVSLTYK 833
+N + ++ + IA G Y E + GP + ++V+ D + Y+
Sbjct: 721 SINSDWKIELPGEFQIA-GTTVRYVRRGLWEKISAKGPTKLPLHLMVLLFHDQDYGIHYE 779
Query: 834 YMIHEDSLNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDH--KMVH 891
Y + + + + + ++ W W CS CGGG + T C R ++ +V+
Sbjct: 780 YTVPVNRTAENQSEPEKPQDSLFIWTHSGWEGCSVQCGGGERRTIVSCTRIVNKTTTLVN 839
Query: 892 RGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTT 951
C S+P+ R CN C Q WV G W PCS TC + G Q R V C+ L + T
Sbjct: 840 DSDCPQASRPEPQVRRCNLHPC-QSRWVAGPWSPCSATCEK-GFQHREVTCVYQLQNGTH 897
Query: 952 RSVHAKHCNDARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGI 1011
+ +C RP + ++C + C W A WSQCS +CG G +R V C +S G
Sbjct: 898 VATRPLYCPGPRPAAVQSCEGQDCLSIWEASEWSQCSASCGKGVWKRTVAC---TNSQGK 954
Query: 1012 CQ-EERPETARTC 1023
C RP C
Sbjct: 955 CDASTRPRAEEAC 967
Score = 43.9 bits (102), Expect = 0.001
Identities = 25/68 (36%), Positives = 32/68 (47%), Gaps = 3/68 (4%)
Query: 850 EEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACN 909
E+ S YEW WS CS CG G Q C ++ + H C ALSKP A R C
Sbjct: 968 EDYSGCYEWKTGDWSTCSSTCGKGLQSRVVQCMHKVTGR--HGSECPALSKP-APYRQCY 1024
Query: 910 PQECSQPV 917
+ C+ +
Sbjct: 1025 QEVCNDRI 1032
Score = 33.1 bits (74), Expect = 1.6
Identities = 18/57 (31%), Positives = 28/57 (49%), Gaps = 5/57 (8%)
Query: 565 GAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLA--YDFQLCSRQDCPDSL 619
G WS +CS TCG G++ R QC + G C L+ ++ C ++ C D +
Sbjct: 979 GDWS---TCSSTCGKGLQSRVVQCMHKVTGRHGSECPALSKPAPYRQCYQEVCNDRI 1032
Score = 32.0 bits (71), Expect = 3.7
Identities = 26/77 (33%), Positives = 30/77 (38%), Gaps = 6/77 (7%)
Query: 977 GRWRA-GPWSQCSVTCGNGTQERPVLCRTADDSFG--ICQEERPETARTCRLGPCPRNIS 1033
G W G WS CS TCG G + R C G C E A C PCP+ +
Sbjct: 544 GDWSPWGAWSMCSRTCGTGARFRQRKCDNPPPGPGGTHCPGASVEHA-VCENLPCPKGL- 601
Query: 1034 DPSKKSYVVQWLSRPDP 1050
PS + Q R P
Sbjct: 602 -PSFRDQQCQAHDRLSP 617
>gi|112789555 ADAM metallopeptidase with thrombospondin type 1 motif,
19 preproprotein [Homo sapiens]
Length = 1207
Score = 446 bits (1146), Expect = e-125
Identities = 325/1098 (29%), Positives = 491/1098 (44%), Gaps = 143/1098 (13%)
Query: 91 PVRTPSFPGGNEEEP-GSHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGTTRV- 148
P PS P EP G + + F RDL+L LR + R +AP +E + G
Sbjct: 146 PQPPPSPPPAQHAEPDGDEVLLRIPAFSRDLYLLLRRDGRFLAPRFAVEQRPNPGPGPTG 205
Query: 149 --------EPLLGSCLYVGDVAGLAEASSVA-LSNCDG-LAGLIRMEEEEFFIEPLEKGL 198
P C Y G V L S+A S C G L G I++ E+ FIEPL +
Sbjct: 206 AASAPQPPAPPDAGCFYTGAV--LRHPGSLASFSTCGGGLMGFIQLNEDFIFIEPLNDTM 263
Query: 199 AAQEAEQGRVHVVYRRPPT-SPPLGGPQALDT---GASLDSLDSLSRALGVLEEHANSSR 254
A G H VYR+ + + AL + G D SR + A S R
Sbjct: 264 AIT----GHPHRVYRQKRSMEEKVTEKSALHSHYCGIISDKGRPRSRKI------AESGR 313
Query: 255 RRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVV 314
+ + +YNIE ++ D ++V +HG + ++++LT++N+V ++ +SL +N+
Sbjct: 314 GKRYSYKLPQEYNIETVVVADPAMVSYHGADAARRFILTILNMVFNLFQHKSLSVQVNLR 373
Query: 315 LVRIILLSYGKSMSLIEIGNPSQS-LENVCRWAY----------LQQKPDTGHDEYH-DH 362
++++ILL ++ + IG+ + LE+ C+W + L+ + G D D
Sbjct: 374 VIKLILLH--ETPPELYIGHHGEKMLESFCKWQHEEFGKKNDIHLEMSTNWGEDMTSVDA 431
Query: 363 AIFLTRQDF-----GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGME 417
AI +TR+DF P G A ++GMC R C + ++G + AF +AHE GH +G+
Sbjct: 432 AILITRKDFCVHKDEPCDTVGIAYLSGMCSEKRKCIIAEDNGLNLAFTIAHEMGHNMGIN 491
Query: 418 HDGQGNRCGDEVRLGSIMAPLVQAA-FHRFHWSRCSQQELSRYLHSY--DCLLD-DPFAH 473
HD C D + + S ++ WSRCS+++L R+L S +CLL +P +
Sbjct: 492 HDNDHPSCADGLHIMS--GEWIKGQNLGDVSWSRCSKEDLERFLRSKASNCLLQTNPQSV 549
Query: 474 DWPALP-QLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPYFCKTKKGP 532
+ +P +LPG+ Y+ +EQC+ FG C + C LWC + C+TK P
Sbjct: 550 NSVMVPSKLPGMTYTADEQCQILFGPLASFCQEMQHVI-CTGLWCK-VEGEKECRTKLDP 607
Query: 533 PLDGTMCAPGKHCFKGHCIWLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPH 592
P+DGT C GK C G C T G W WSP CSRTC G+ R R+C P
Sbjct: 608 PMDGTDCDLGKWCKAGECTSRTSAPEHLAGEWSLWSP---CSRTCSAGISSRERKC--PG 662
Query: 593 PANGGRTCSGLAYDFQLCSRQDCPDSLADFREEQCRQWDLYFEHGDAQHHWLPHEHRDAK 652
+ R C+G +++C CP L FR+ QC+ + + W D +
Sbjct: 663 LDSEARDCNGPRKQYRICENPPCPAGLPGFRDWQCQAYSVRTSSPKHILQW--QAVLDEE 720
Query: 653 ERCHLYCESRETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKC 712
+ C L+C + + + V DGT C Y+ +C G C+KVGCDG++GS +ED C
Sbjct: 721 KPCALFCSPVGKEQPILLSEKVMDGTSCGYQ-GLDICANGRCQKVGCDGLLGSLAREDHC 779
Query: 713 GVCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGK 772
GVC G+ CK++KG F + + GY+++ IPAGAR + + E +LA++ + GK
Sbjct: 780 GVCNGNGKSCKIIKGDFNHT-RGAGYVEVLVIPAGARRIKVVEEKPAHSYLALR--DAGK 836
Query: 773 FILNEENDVDASSKTFIAMGVEWEYRDEDGRETLQTMGPLHGTITVLVIPVGDTRVSLTY 832
+N + ++ S F G Y E + GP + +LV+ D L Y
Sbjct: 837 QSINSDWKIEHSG-AFNLAGTTVHYVRRGLWEKISAKGPTTAPLHLLVLLFQDQNYGLHY 895
Query: 833 KYMIHEDSLNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDH--KMV 890
+Y I D L +N + ++ W W C CGGG + T C + + +V
Sbjct: 896 EYTIPSDPL--PENQSSKAPEPLFMWTHTSWEDCDATCGGGERKTTVSCTKIMSKNISIV 953
Query: 891 HRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNT 950
C L+KP+ R CN Q C Q W+ EW PCS+TCG+ GMQ R V C Q L + T
Sbjct: 954 DNEKCKYLTKPEPQIRKCNEQPC-QTRWMMTEWTPCSRTCGK-GMQSRQVACTQQLSNGT 1011
Query: 951 TRSVHAKHCNDARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLC-------- 1002
+ C +P S + C + C W AG WS+CSV CG G + R V C
Sbjct: 1012 LIRARERDCIGPKPASAQRCEGQDCMTVWEAGVWSECSVKCGKGIRHRTVRCTNPRKKCV 1071
Query: 1003 -----RTADD--SFGIC---------------------------------------QEER 1016
R A+D + C E+
Sbjct: 1072 LSTRPREAEDCEDYSKCYVWRMGDWSKCSITCGKGMQSRVIQCMHKITGRHGNECFSSEK 1131
Query: 1017 PETARTCRLGPCPRNISDPSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDK-SIFCRMEV 1075
P R C L PC I+ V ++ P R + C GD+ ++CR+
Sbjct: 1132 PAAYRPCHLQPCNEKIN--------VNTITSP------RLAALTFKCLGDQWPVYCRVIR 1177
Query: 1076 LSRYCSIPGYNKLCCKSC 1093
C + + CC++C
Sbjct: 1178 EKNLCQDMRWYQRCCETC 1195
>gi|21265058 a disintegrin-like and metalloprotease (reprolysin
type) with thrombospondin type 1 motif, 15 preproprotein
[Homo sapiens]
Length = 950
Score = 439 bits (1129), Expect = e-123
Identities = 311/899 (34%), Positives = 433/899 (48%), Gaps = 76/899 (8%)
Query: 100 GNEEEPGSHLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGE--KGTTRVEPLLGSCLY 157
G E+ L + +T F D +L L P+A+ +AP + E G +G T L C Y
Sbjct: 44 GPEDSGDQGLIFQITAFQEDFYLHLTPDAQFLAPAFSTEHLGVPLQGLTGGSSDLRRCFY 103
Query: 158 VGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLA--AQEAEQGRVHVVYRRP 215
GDV + S A+S C GL G E+ I PL A AQ QG H++ RR
Sbjct: 104 SGDVNAEPD-SFAAVSLCGGLRGAFGYRGAEYVISPLPNASAPAAQRNSQG-AHLLQRRG 161
Query: 216 PTSPPLGGPQALDTGAS------LDSLDSLS-RALGVLEEHANSSRRRARRHAADDDYNI 268
P G P + AS L +LD R G E + RA+R + Y +
Sbjct: 162 VPGGPSGDPTSRCGVASGWNPAILRALDPYKPRRAGFGESRSRRRSGRAKRFVSIPRY-V 220
Query: 269 EVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMS 328
E L+ D+S+V+FHG + ++ YLLTL+ +Y S+ IN+V+V+++LL S
Sbjct: 221 ETLVVADESMVKFHGAD-LEHYLLTLLATAARLYRHPSILNPINIVVVKVLLLRDRDSGP 279
Query: 329 LIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPS---GMQGYAPVTGM 385
+ GN + +L N C W K H EY D AI TRQD + G A V M
Sbjct: 280 KVT-GNAALTLRNFCAWQKKLNKVSDKHPEYWDTAILFTRQDLCGATTCDTLGMADVGTM 338
Query: 386 CHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQG--NRCGDEVRLGSIMAPLVQAAF 443
C P RSC++ +DG SAF AHE GHV M HD ++R +M+P +
Sbjct: 339 CDPKRSCSVIEDDGLPSAFTTAHELGHVFNMPHDNVKVCEEVFGKLRANHMMSPTLIQID 398
Query: 444 HRFHWSRCSQQELSRYLHSY--DCLLDDPFAHDWPALPQ-LPGLHYSMNEQCRFDFGLGY 500
WS CS ++ +L S DCLLD P +LP+ LPG Y++++QC FG+G
Sbjct: 399 RANPWSACSAAIITDFLDSGHGDCLLDQPSKPI--SLPEDLPGASYTLSQQCELAFGVGS 456
Query: 501 MMCTAFRTFDPCKQLWCS-HPDNPYFCKTKKGPPLDGTMCAPGKHCFKGHCIWLTPDILK 559
C + C +LWC+ C+T+ P DGT C GK C KG C+
Sbjct: 457 KPCPYMQY---CTKLWCTGKAKGQMVCQTRHFPWADGTSCGEGKLCLKGACVERHNLNKH 513
Query: 560 R-DGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDS 618
R DGSW W P+G CSRTCG GV+ RQC NP PANGG+ C G+ ++ C+ + CP S
Sbjct: 514 RVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVKYRSCNLEPCPSS 573
Query: 619 LA--DFREEQCRQWDLYFEHGD---AQHHWLP-HEHRDAKERCHLYCESRETGEVVSMKR 672
+ FREEQC ++ Y + W+P + +++C L C + TG +
Sbjct: 574 ASGKSFREEQCEAFNGYNHSTNRLTLAVAWVPKYSGVSPRDKCKLICRANGTGYFYVLAP 633
Query: 673 MVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRS 732
V DGT CS D+ S+CV+G C K GCDG +GS K+ DKCGVCGGDN CK V G FT+
Sbjct: 634 KVVDGTLCS-PDSTSVCVQGKCIKAGCDGNLGSKKRFDKCGVCGGDNKSCKKVTGLFTK- 691
Query: 733 PKKHGYIKMFEIPAGARHLLIQE-----VDATSHHLAVKNLETGKFILNEENDVDASSKT 787
HGY + IPAGA + I++ + ++LA+KN + GK++LN V A +
Sbjct: 692 -PMHGYNFVVAIPAGASSIDIRQRGYKGLIGDDNYLALKNSQ-GKYLLNGHFVVSAVERD 749
Query: 788 FIAMGVEWEYRDE-DGRETLQTMGPLHGTITVLVIPVGD-TRVSLTYKY----------- 834
+ G Y E+LQ P+ +TV V+ VG T + Y +
Sbjct: 750 LVVKGSLLRYSGTGTAVESLQASRPILEPLTVEVLSVGKMTPPRVRYSFYLPKEPREDKS 809
Query: 835 ----------MIHEDSLNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRR 884
++H L++ + +D W W PCS CG G Q CR
Sbjct: 810 SHPKDPRGPSVLHNSVLSLSNQVEQPDDRPPARWVAGSWGPCSASCGSGLQKRAVDCRGS 869
Query: 885 LDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCI 943
+ V C A +P +AC + C P W W PCS++CGR G Q RS++C+
Sbjct: 870 AGQRTVPA--CDAAHRP-VETQACG-EPC--PTWELSAWSPCSKSCGR-GFQRRSLKCV 921
Score = 43.9 bits (102), Expect = 0.001
Identities = 23/57 (40%), Positives = 28/57 (49%), Gaps = 4/57 (7%)
Query: 976 PGRWRAGPWSQCSVTCGNGTQERPVLCR--TADDSFGICQ-EERPETARTCRLGPCP 1029
P RW AG W CS +CG+G Q+R V CR + C RP + C PCP
Sbjct: 840 PARWVAGSWGPCSASCGSGLQKRAVDCRGSAGQRTVPACDAAHRPVETQACG-EPCP 895
Score = 35.4 bits (80), Expect = 0.33
Identities = 36/129 (27%), Positives = 52/129 (40%), Gaps = 16/129 (12%)
Query: 911 QECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRAC 970
Q C++ +W TG+ + G+ Q R P D T+ K C R
Sbjct: 463 QYCTK-LWCTGKAK------GQMVCQTRHF----PWADGTSCG-EGKLCLKGACVERHNL 510
Query: 971 SRELCPGRW-RAGPWSQCSVTCGNGTQERPVLCRTADDSFG--ICQEERPETARTCRLGP 1027
++ G W + P+ CS TCG G Q C + G C+ R + R+C L P
Sbjct: 511 NKHRVDGSWAKWDPYGPCSRTCGGGVQLARRQCTNPTPANGGKYCEGVRVK-YRSCNLEP 569
Query: 1028 CPRNISDPS 1036
CP + S S
Sbjct: 570 CPSSASGKS 578
>gi|50845384 ADAM metallopeptidase with thrombospondin type 1 motif,
1 preproprotein [Homo sapiens]
Length = 967
Score = 402 bits (1032), Expect = e-111
Identities = 290/892 (32%), Positives = 426/892 (47%), Gaps = 92/892 (10%)
Query: 116 FGRDLHLRLRPNARLVAPGATMEWQGEKG---TTRVEPLLGSCLYVGDVAGLAEASSVAL 172
F + L L LRP++ +APG T++ G K T E L C Y G V G +S+ AL
Sbjct: 81 FDQQLDLELRPDSSFLAPGFTLQNVGRKSGSETPLPETDLAHCFYSGTVNG-DPSSAAAL 139
Query: 173 SNCDGLAGLIRMEEEEFFIEPL----EKGLAAQEAEQG----RVHVVYR----------- 213
S C+G+ G + E +FI+PL E+ A E+ + H++ R
Sbjct: 140 SLCEGVRGAFYLLGEAYFIQPLPAASERLATAAPGEKPPAPLQFHLLRRNRQGDVGGTCG 199
Query: 214 ----------RPPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRRRARRHAAD 263
+ T G + D GA D + +G + + R +R +
Sbjct: 200 VVDDEPRPTGKAETEDEDEGTEGEDEGAQWSPQDPALQGVG---QPTGTGSIRKKRFVSS 256
Query: 264 DDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSY 323
Y +E +L D S+ +FHG ++ YLLTL ++ +Y S+ +++V+V+I+++ +
Sbjct: 257 HRY-VETMLVADQSMAEFHGSG-LKHYLLTLFSVAARLYKHPSIRNSVSLVVVKILVI-H 313
Query: 324 GKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDFGPS---GMQGYA 380
+ N + +L N C W P E++D AI TRQD S G A
Sbjct: 314 DEQKGPEVTSNAALTLRNFCNWQKQHNPPSDRDAEHYDTAILFTRQDLCGSQTCDTLGMA 373
Query: 381 PVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVRLGS---IMAP 437
V +C P RSC++ +DG +AF AHE GHV M HD +C + +MA
Sbjct: 374 DVGTVCDPSRSCSVIEDDGLQAAFTTAHELGHVFNMPHD-DAKQCASLNGVNQDSHMMAS 432
Query: 438 LVQAAFHRFHWSRCSQQELSRYLHSY--DCLLDDPFAHDWPALP-QLPGLHYSMNEQCRF 494
++ H WS CS ++ +L + +CL+D P + LP LPG Y N QC+F
Sbjct: 433 MLSNLDHSQPWSPCSAYMITSFLDNGHGECLMDKP--QNPIQLPGDLPGTSYDANRQCQF 490
Query: 495 DFGLGYMMCTAFRTFDPCKQLWCSHPDNPYF-CKTKKGPPLDGTMCAPGKHCFKGHCIWL 553
FG C + C LWC+ C+TK P DGT C GK C G C+
Sbjct: 491 TFGEDSKHCPDAAS--TCSTLWCTGTSGGVLVCQTKHFPWADGTSCGEGKWCINGKCVNK 548
Query: 554 TPDILKRD----GSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQL 609
T D D GSWG W P+G CSRTCG GV++ R+CDNP P NGG+ C G ++
Sbjct: 549 T-DRKHFDTPFHGSWGMWGPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVRYRS 607
Query: 610 CSRQDCPDSLA-DFREEQCRQWDLY----FEHGDAQHHWLP-HEHRDAKERCHLYCESRE 663
C+ +DCPD+ FREEQC + + F G A W+P + K+RC L C+++
Sbjct: 608 CNLEDCPDNNGKTFREEQCEAHNEFSKASFGSGPAV-EWIPKYAGVSPKDRCKLICQAKG 666
Query: 664 TGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCK 723
G ++ V DGT CS D+ S+CV+G C K GCD +I S K+ DKCGVCGG+ S CK
Sbjct: 667 IGYFFVLQPKVVDGTPCS-PDSTSVCVQGQCVKAGCDRIIDSKKKFDKCGVCGGNGSTCK 725
Query: 724 VVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDA-----TSHHLAVKNLETGKFILNEE 778
+ G+ T + K GY + IP GA ++ +++ + LA+K + G +ILN +
Sbjct: 726 KISGSVTSA--KPGYHDIITIPTGATNIEVKQRNQRGSRNNGSFLAIKAAD-GTYILNGD 782
Query: 779 NDVDASSKTFIAMGVEWEYRDEDGR-ETLQTMGPLHGTITVLVIPVGDT-RVSLTYKYMI 836
+ + + GV Y E +++ PL +T+ V+ VG+ R + Y Y +
Sbjct: 783 YTLSTLEQDIMYKGVVLRYSGSSAALERIRSFSPLKEPLTIQVLTVGNALRPKIKYTYFV 842
Query: 837 HEDSLNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCA 896
+ + N + S W +++W CSK C G Q CR D CA
Sbjct: 843 KKKK---ESFNAIPTFSA---WVIEEWGECSKSCELGWQRRLVECR---DINGQPASECA 893
Query: 897 ALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHD 948
KP A R C C P W GEW CS+TCG+ G + RS++C+ HD
Sbjct: 894 KEVKP-ASTRPCADHPC--PQWQLGEWSSCSKTCGK-GYKKRSLKCLS--HD 939
Score = 61.2 bits (147), Expect = 6e-09
Identities = 33/90 (36%), Positives = 44/90 (48%), Gaps = 9/90 (10%)
Query: 918 WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHC-NDARPESRRACSRELCP 976
WV EW CS++C G Q R V C A C + +P S R C+ CP
Sbjct: 858 WVIEEWGECSKSC-ELGWQRRLVEC------RDINGQPASECAKEVKPASTRPCADHPCP 910
Query: 977 GRWRAGPWSQCSVTCGNGTQERPVLCRTAD 1006
+W+ G WS CS TCG G ++R + C + D
Sbjct: 911 -QWQLGEWSSCSKTCGKGYKKRSLKCLSHD 939
Score = 37.0 bits (84), Expect = 0.11
Identities = 18/54 (33%), Positives = 25/54 (46%), Gaps = 2/54 (3%)
Query: 979 WRAGPWSQCSVTCGNGTQERPVLCR--TADDSFGICQEERPETARTCRLGPCPR 1030
W W +CS +C G Q R V CR + +E +P + R C PCP+
Sbjct: 858 WVIEEWGECSKSCELGWQRRLVECRDINGQPASECAKEVKPASTRPCADHPCPQ 911
Score = 36.6 bits (83), Expect = 0.15
Identities = 22/57 (38%), Positives = 25/57 (43%), Gaps = 5/57 (8%)
Query: 977 GRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFG--ICQEERPETARTCRLGPCPRN 1031
G W GPW CS TCG G Q C G C+ +R R+C L CP N
Sbjct: 563 GMW--GPWGDCSRTCGGGVQYTMRECDNPVPKNGGKYCEGKRVR-YRSCNLEDCPDN 616
>gi|153792351 ADAM metallopeptidase with thrombospondin type 1
motif, 8 preproprotein [Homo sapiens]
Length = 889
Score = 379 bits (972), Expect = e-104
Identities = 297/952 (31%), Positives = 431/952 (45%), Gaps = 151/952 (15%)
Query: 88 RAAPVRTPSFPGGNEEE-------PGS--HLFYNVTVFGRDLHLRLRPNARLVAPGATME 138
R AP R + GG E PGS L +++ FG+ LRL P+ +AP +E
Sbjct: 25 RGAPARPAA--GGQASELVVPTRLPGSAGELALHLSAFGKGFVLRLAPDDSFLAPEFKIE 82
Query: 139 WQGEKG-TTRVEPLLGSCLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKG 197
G G T E L C + G V G E S A+S C GL+G ++ EEF I+P +G
Sbjct: 83 RLGGSGRATGGERGLRGCFFSGTVNGEPE-SLAAVSLCRGLSGSFLLDGEEFTIQP--QG 139
Query: 198 LAAQEAEQGRVH--------VVYRRPPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEH 249
A+ R+ + R P G Q + G + + S+ EE
Sbjct: 140 AGGSLAQPHRLQRWGPAGARPLPRGPEWEVETGEGQRQERGDHQEDSEEESQ-----EEE 194
Query: 250 ANSSRR---------RARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNE 300
A + R +R ++ + +E LL D S+ F+G + +Q ++LTLM++
Sbjct: 195 AEGASEPPPPLGATSRTKRFVSEARF-VETLLVADASMAAFYGAD-LQNHILTLMSVAAR 252
Query: 301 IYHDESLGAHINVVLVRIILLS---YGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHD 357
IY S+ IN+++V+++++ +G +S N +L N C W +P H
Sbjct: 253 IYKHPSIKNSINLMVVKVLIVEDEKWGPEVS----DNGGLTLRNFCNWQRRFNQPSDRHP 308
Query: 358 EYHDHAIFLTRQDF-GPSGM---QGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHV 413
E++D AI LTRQ+F G G+ G A + +C P +SC++ ++G +A +AHE GHV
Sbjct: 309 EHYDTAILLTRQNFCGQEGLCDTLGVADIGTICDPNKSCSVIEDEGLQAAHTLAHELGHV 368
Query: 414 LGMEHDGQG--NRCGDEVRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSY--DCLLDD 469
L M HD R + +MAPL WS CS L+ L DCLLD
Sbjct: 369 LSMPHDDSKPCTRLFGPMGKHHVMAPLFVHLNQTLPWSPCSAMYLTELLDGGHGDCLLDA 428
Query: 470 PFAHDWPALPQLPGLH-----YSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHPDNPY 524
P A ALP GL Y +++QCR FG + C D C QLWC
Sbjct: 429 PAA----ALPLPTGLPGRMALYQLDQQCRQIFGPDFRHCPNTSAQDVCAQLWCHTDGAEP 484
Query: 525 FCKTKKG--PPLDGTMCAPGKHCFKGHCIWLTPDILKR-----DGSWGAWSPFGSCSRTC 577
C TK G P DGT C PG C +G C L + ++R DG W W P+G CSRTC
Sbjct: 485 LCHTKNGSLPWADGTPCGPGHLCSEGSC--LPEEEVERPKPVADGGWAPWGPWGECSRTC 542
Query: 578 GTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLADFREEQCRQWDLYFEHG 637
G GV+F R+C +P P NGGR C G +Q C ++CP FRE+QC +++ Y +
Sbjct: 543 GGGVQFSHRECKDPEPQNGGRYCLGRRAKYQSCHTEECPPDGKSFREQQCEKYNAY-NYT 601
Query: 638 DAQHH---WLP-HEHRDAKERCHLYCESRETGEVVSMKRMVHDGTRCSYKDAFSLCVRGD 693
D + W+P + ++RC L+C +R E + V DGT C + ++CVRG
Sbjct: 602 DMDGNLLQWVPKYAGVSPRDRCKLFCRARGRSEFKVFEAKVIDGTLCG-PETLAICVRGQ 660
Query: 694 CRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLI 753
C K GCD V+ S ++ DKCGVCGG + C+ V G+ T P +GY + IPAGA ++ +
Sbjct: 661 CVKAGCDHVVDSPRKLDKCGVCGGKGNSCRKVSGSLT--PTNYGYNDIVTIPAGATNIDV 718
Query: 754 QE-----VDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGVEWEYRDEDGR-ETLQ 807
++ V ++LA+K + G+++LN + A + + G +Y E LQ
Sbjct: 719 KQRSHPGVQNDGNYLALKTAD-GQYLLNGNLAISAIEQDILVKGTILKYSGSIATLERLQ 777
Query: 808 TMGPLHGTITV--LVIPVGDTRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYEWALKKWSP 865
+ PL +TV L +P + Y + + D VD
Sbjct: 778 SFRPLPEPLTVQLLTVPGEVFPPKVKYTFFVPND---VD--------------------- 813
Query: 866 CSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEP 925
F SK +A P +Q WV G+W
Sbjct: 814 ----------------------------FSMQSSKERATTNIIQPLLHAQ--WVLGDWSE 843
Query: 926 CSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDA-RPESRRACSRELCP 976
CS TCG G Q R+V C P + CN A +PE + C +LCP
Sbjct: 844 CSSTCG-AGWQRRTVECRDPSGQASAT------CNKALKPEDAKPCESQLCP 888
Score = 45.4 bits (106), Expect = 3e-04
Identities = 23/58 (39%), Positives = 30/58 (51%), Gaps = 2/58 (3%)
Query: 974 LCPGRWRAGPWSQCSVTCGNGTQERPVLCR-TADDSFGICQEE-RPETARTCRLGPCP 1029
L +W G WS+CS TCG G Q R V CR + + C + +PE A+ C CP
Sbjct: 831 LLHAQWVLGDWSECSSTCGAGWQRRTVECRDPSGQASATCNKALKPEDAKPCESQLCP 888
Score = 35.4 bits (80), Expect = 0.33
Identities = 24/80 (30%), Positives = 33/80 (41%), Gaps = 9/80 (11%)
Query: 964 PESRRACSRELCPGRWRA-GPWSQCSVTCGNGTQERPVLCRTADDSFG--ICQEERPETA 1020
PE + + G W GPW +CS TCG G Q C+ + G C R +
Sbjct: 514 PEEEVERPKPVADGGWAPWGPWGECSRTCGGGVQFSHRECKDPEPQNGGRYCLGRRAK-Y 572
Query: 1021 RTCRLGPCPRNISDPSKKSY 1040
++C CP P KS+
Sbjct: 573 QSCHTEECP-----PDGKSF 587
>gi|195539372 ADAM metallopeptidase with thrombospondin type 1
motif, 5 preproprotein [Homo sapiens]
Length = 930
Score = 346 bits (887), Expect = 9e-95
Identities = 271/881 (30%), Positives = 394/881 (44%), Gaps = 140/881 (15%)
Query: 155 CLYVGDVAGLAEASSVALSNCDGLAGLIRMEEEEFFIEPLEKGLAAQEAEQGRVHV---- 210
C Y G V G + +V C GL G ++ + ++PL +G A+E E+GRV+
Sbjct: 130 CFYRGTVDGSPRSLAV-FDLCGGLDGFFAVKHARYTLKPLLRGPWAEE-EKGRVYGDGSA 187
Query: 211 ----VYRRPPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRR----------- 255
VY R S +AL AS ++ S A H+N S R
Sbjct: 188 RILHVYTREGFSF-----EALPPRASCETPASTPEAHEHAPAHSNPSGRAALASQLLDQS 242
Query: 256 --------------RARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEI 301
R RR + +E+LL D S+ + +G+ +Q YLLTL +I N +
Sbjct: 243 ALSPAGGSGPQTWWRRRRRSISRARQVELLLVADASMARLYGRG-LQHYLLTLASIANRL 301
Query: 302 YHDESLGAHINVVLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHD 361
Y S+ HI + +V++++L K SL N + +L+N C+W + + H+E++D
Sbjct: 302 YSHASIENHIRLAVVKVVVLG-DKDKSLEVSKNAATTLKNFCKWQHQHNQLGDDHEEHYD 360
Query: 362 HAIFLTRQDF---GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEH 418
AI TR+D G A V +C P RSC + +DG +AF VAHE GH+LG+ H
Sbjct: 361 AAILFTREDLCGHHSCDTLGMADVGTICSPERSCAVIEDDGLHAAFTVAHEIGHLLGLSH 420
Query: 419 DGQGNRCGDEVRLGS-----IMAPLVQAAFHRFHWSRCSQQELSRYLHSY--DCLLDDPF 471
D C E GS +M+ ++ + WS+C+ ++ +L +CLLD P
Sbjct: 421 D-DSKFC--EETFGSTEDKRLMSSILTSIDASKPWSKCTSATITEFLDDGHGNCLLDLP- 476
Query: 472 AHDWPALPQLPGLHYSMNEQCRFDFGLGYMMCTAFRTFDPCKQLWCSHP-DNPYFCKTKK 530
+LPG Y +QC FG Y +C D C +LWC+ C TKK
Sbjct: 477 RKQILGPEELPGQTYDATQQCNLTFGPEYSVCPGM---DVCARLWCAVVRQGQMVCLTKK 533
Query: 531 GPPLDGTMCAPGKHCFKGHCIWLTPD---ILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQ 587
P ++GT C G+ C +G C+ T G+WG+W +G CSR+CG GV+F R
Sbjct: 534 LPAVEGTPCGKGRICLQGKCVDKTKKKYYSTSSHGNWGSWGSWGQCSRSCGGGVQFAYRH 593
Query: 588 CDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLADFREEQCRQWDLYFEHGDAQH-----H 642
C+NP P N GR C+G ++ CS CP + FR EQC + Y DA+
Sbjct: 594 CNNPAPRNNGRYCTGKRAIYRSCSLMPCPPNGKSFRHEQCEAKNGY--QSDAKGVKTFVE 651
Query: 643 WLP-HEHRDAKERCHLYCESRETGEVVSMKRMVHDGTRCSYKDAFSLCVRGDCRKVGCDG 701
W+P + + C L C ++ TG V V DGT C S+CVRG C + GCDG
Sbjct: 652 WVPKYAGVLPADVCKLTCRAKGTGYYVVFSPKVTDGTECRLYSN-SVCVRGKCVRTGCDG 710
Query: 702 VIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSH 761
+IGS Q DKCGVCGGDNS C + GTF + K GY + IP GA H+ +++ A
Sbjct: 711 IIGSKLQYDKCGVCGGDNSSCTKIVGTFNKKSK--GYTDVVRIPEGATHIKVRQFKAKDQ 768
Query: 762 -----HLAVKNLETGKFILNEENDVDASSKTFIAMGVEWEYRDEDGRET-LQTMGPLHGT 815
+LA+K + G++++N + + S G Y R+ L MG T
Sbjct: 769 TRFTAYLALKK-KNGEYLINGKYMISTSETIIDINGTVMNYSGWSHRDDFLHGMG-YSAT 826
Query: 816 ITVLVIPVGDTRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYEWALKKWSPCSKPCGGGSQ 875
+L++ + L D L+ V Y + + K K +
Sbjct: 827 KEILIVQI-----------------LATDPTKPLD---VRYSFFVPK-----KSTPKVNS 861
Query: 876 FTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQTCGRTGM 935
T +G + H SQP WVTG W CS+TC TG
Sbjct: 862 VTSHGSNKVGSHT-------------------------SQPQWVTGPWLACSRTCD-TGW 895
Query: 936 QVRSVRCIQPLHDNTTRSVHAKHCN-DARPESRRACSRELC 975
R+V+C D + AK C RP + + C + C
Sbjct: 896 HTRTVQC----QDGNRKL--AKGCPLSQRPSAFKQCLLKKC 930
Score = 38.1 bits (87), Expect = 0.051
Identities = 18/53 (33%), Positives = 23/53 (43%), Gaps = 2/53 (3%)
Query: 978 RWRAGPWSQCSVTCGNGTQERPVLCRTADDSF--GICQEERPETARTCRLGPC 1028
+W GPW CS TC G R V C+ + G +RP + C L C
Sbjct: 878 QWVTGPWLACSRTCDTGWHTRTVQCQDGNRKLAKGCPLSQRPSAFKQCLLKKC 930
Score = 34.7 bits (78), Expect = 0.57
Identities = 21/57 (36%), Positives = 26/57 (45%), Gaps = 2/57 (3%)
Query: 977 GRWRA-GPWSQCSVTCGNGTQERPVLCRT-ADDSFGICQEERPETARTCRLGPCPRN 1031
G W + G W QCS +CG G Q C A + G + R+C L PCP N
Sbjct: 568 GNWGSWGSWGQCSRSCGGGVQFAYRHCNNPAPRNNGRYCTGKRAIYRSCSLMPCPPN 624
Score = 31.2 bits (69), Expect = 6.3
Identities = 21/72 (29%), Positives = 30/72 (41%), Gaps = 7/72 (9%)
Query: 921 GEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCPGRWR 980
G W CS++CG G+Q C P N + ++C R R+CS CP +
Sbjct: 574 GSWGQCSRSCG-GGVQFAYRHCNNPAPRN-----NGRYCTGKR-AIYRSCSLMPCPPNGK 626
Query: 981 AGPWSQCSVTCG 992
+ QC G
Sbjct: 627 SFRHEQCEAKNG 638
>gi|73695936 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 2 preproprotein [Homo sapiens]
Length = 1371
Score = 333 bits (853), Expect = 8e-91
Identities = 252/794 (31%), Positives = 359/794 (45%), Gaps = 91/794 (11%)
Query: 254 RRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINV 313
+R+ +R AA ++E+L+ V V Q H +E ++Y+LT +NI E+ D SLGA V
Sbjct: 68 QRQRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRV 126
Query: 314 VLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDF-- 371
LV++++L+ + I N + SL +VC W+ D + D +++TR D
Sbjct: 127 HLVKMVILTEPEGAPNIT-ANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLEL 185
Query: 372 --GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQ-GNRCGDE 428
G ++G + G C P SC + + GF +AHE GH G+EHDG G+ CG
Sbjct: 186 PDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS 245
Query: 429 VRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHS--YDCLLDDPFAHDWPA---LPQLPG 483
G +MA A WS CS+++L L + C+ D P A PG
Sbjct: 246 ---GHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQPG 302
Query: 484 LHYSMNEQCRFDFGLGYMMCTAFRT-FDPCKQLWC-SHPDNPYFCKTKKGPPLDGTMCAP 541
L+YS NEQCR FG + CT R D C+ L C + P + C P LDGT C
Sbjct: 303 LYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGV 362
Query: 542 GKHCFKGHC---IWLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGR 598
K C KG C + LTP I G W +W P CSR+CG GV R RQC+NP PA GGR
Sbjct: 363 EKWCSKGRCRSLVELTP-IAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGR 421
Query: 599 TCSGLAYDFQLCSRQDCPDSLADFREEQCRQWD---LYFEHGDAQ-HHW---LPHEHRDA 651
C G ++C+ Q C + +F +QC + D L G A +HW +PH DA
Sbjct: 422 ACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDA 481
Query: 652 KERCHLYCESRETGEVVSMKR--MVHDGTRC-----SYKDAFSLCVRGDCRKVGCDGVIG 704
C C R GE MKR DGTRC SLCV G CR GCDG +
Sbjct: 482 --LCRHMC--RAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMD 537
Query: 705 SSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSHHLA 764
S + D+C VCGGDNS C KG+FT + + Y+ + + I HLA
Sbjct: 538 SQQVWDRCQVCGGDNSTCSPRKGSFT-AGRAREYVTFLTVTPNLTSVYIANHRPLFTHLA 596
Query: 765 VKNLETGKFILNEENDVDASSKTFIAMGVEWEYRDEDGR---------------ETLQTM 809
V+ G++++ + K I+ + EDGR E ++
Sbjct: 597 VR--IGGRYVV--------AGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIW 646
Query: 810 GPLHGTITVLVI-PVGD-----TRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYEWALKKW 863
GPL + V G+ TR +T+ Y + + WA +
Sbjct: 647 GPLQEDADIQVYRRYGEEYGNLTRPDITFTYF-------------QPKPRQAWVWAAVR- 692
Query: 864 SPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEW 923
PCS CG G ++ Y C + ++V C +P A AC + C P W G++
Sbjct: 693 GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPC-PPYWAVGDF 751
Query: 924 EPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPE---SRRACSRELCPGRWR 980
PCS +CG G++ R VRC++ + +++ C + + C+ + CP RW
Sbjct: 752 GPCSASCG-GGLRERPVRCVE-AQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWE 809
Query: 981 AGPWSQCSVTCGNG 994
S C+ G G
Sbjct: 810 VSEPSSCTSAGGAG 823
Score = 74.7 bits (182), Expect = 5e-13
Identities = 56/176 (31%), Positives = 72/176 (40%), Gaps = 12/176 (6%)
Query: 862 KWSPCSKPCGGGSQFTKYGCRRRLDH----KMVHRGFCAALSKPKAIRRACNPQECSQPV 917
K + CS CG G C R +++ C L +P+ + AC+ + C P
Sbjct: 958 KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEP-QEACSLEPCP-PR 1015
Query: 918 WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCPG 977
W PCS +CG G RSV C+Q A RPE+ C C
Sbjct: 1016 WKVMSLGPCSASCG-LGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTY 1074
Query: 978 RWRAGPWSQCSVTCGNGTQERPVLC----RTADDSFGICQE-ERPETARTCRLGPC 1028
RW G W +CSV+CG+G Q R C A CQ +P T R C GPC
Sbjct: 1075 RWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
Score = 73.6 bits (179), Expect = 1e-12
Identities = 54/179 (30%), Positives = 72/179 (40%), Gaps = 16/179 (8%)
Query: 863 WSP----CSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVW 918
W+P CS CG G ++ C V C SKP + R C C P
Sbjct: 897 WTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPC--PAR 954
Query: 919 VTGEWEPCSQTCGRTGMQVRSVRCIQPL-HDNTTRSVHAKHCNDA-RPESRRACSRELCP 976
+ CS +CGR G+ R + C + D+ + C RPE + ACS E CP
Sbjct: 955 WQYKLAACSVSCGR-GVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCP 1013
Query: 977 GRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQEE-------RPETARTCRLGPC 1028
RW+ CS +CG GT R V C D + +E RPE + C + C
Sbjct: 1014 PRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADC 1072
Score = 52.8 bits (125), Expect = 2e-06
Identities = 46/123 (37%), Positives = 58/123 (47%), Gaps = 22/123 (17%)
Query: 923 WEP----CSQTCGRTGMQVRSVRCIQPLHDNTTR-SVHAKHCNDA-RPESRR-ACSRELC 975
W P CS +CGR M++R + C+ D+ R V + C A +P SRR C C
Sbjct: 897 WTPAAGSCSVSCGRGLMELRFL-CM----DSALRVPVQEELCGLASKPGSRREVCQAVPC 951
Query: 976 PGRWRAGPWSQCSVTCGNGTQERPVLCRTA---DDSFGI-----CQE-ERPETARTCRLG 1026
P RW+ + CSV+CG G R + C A DD I CQ RPE C L
Sbjct: 952 PARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLE 1010
Query: 1027 PCP 1029
PCP
Sbjct: 1011 PCP 1013
Score = 47.8 bits (112), Expect = 6e-05
Identities = 38/128 (29%), Positives = 53/128 (41%), Gaps = 9/128 (7%)
Query: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKM---VHRGFCAALSKPKAIRRACNPQECS 914
W + PCS CG G+ C +LD V CAAL +P+A C +C+
Sbjct: 1016 WKVMSLGPCSASCGLGTARRSVAC-VQLDQGQDVEVDEAACAALVRPEA-SVPCLIADCT 1073
Query: 915 QPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSREL 974
W G W CS +CG G+Q R C+ P + +H +P + R C
Sbjct: 1074 YR-WHVGTWMECSVSCG-DGIQRRRDTCLGPQAQAPVPADFCQHL--PKPVTVRGCWAGP 1129
Query: 975 CPGRWRAG 982
C G+ G
Sbjct: 1130 CVGQGACG 1137
Score = 34.7 bits (78), Expect = 0.57
Identities = 17/50 (34%), Positives = 20/50 (40%)
Query: 856 YEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIR 905
Y W + W CS CG G Q + C V FC L KP +R
Sbjct: 1074 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVR 1123
Score = 33.9 bits (76), Expect = 0.96
Identities = 28/76 (36%), Positives = 33/76 (43%), Gaps = 11/76 (14%)
Query: 941 RCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCP-----GRWRA-GPWSQCSVTCGNG 994
R + PL D T V K C+ R S EL P GRW + GP S CS +CG G
Sbjct: 349 RLLVPLLDGTECGVE-KWCSKGRCRSLV----ELTPIAAVHGRWSSWGPRSPCSRSCGGG 403
Query: 995 TQERPVLCRTADDSFG 1010
R C +FG
Sbjct: 404 VVTRRRQCNNPRPAFG 419
>gi|21265034 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 1 preproprotein [Homo sapiens]
Length = 1427
Score = 333 bits (853), Expect = 8e-91
Identities = 252/794 (31%), Positives = 359/794 (45%), Gaps = 91/794 (11%)
Query: 254 RRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINV 313
+R+ +R AA ++E+L+ V V Q H +E ++Y+LT +NI E+ D SLGA V
Sbjct: 68 QRQRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRV 126
Query: 314 VLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDF-- 371
LV++++L+ + I N + SL +VC W+ D + D +++TR D
Sbjct: 127 HLVKMVILTEPEGAPNIT-ANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLEL 185
Query: 372 --GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQ-GNRCGDE 428
G ++G + G C P SC + + GF +AHE GH G+EHDG G+ CG
Sbjct: 186 PDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS 245
Query: 429 VRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHS--YDCLLDDPFAHDWPA---LPQLPG 483
G +MA A WS CS+++L L + C+ D P A PG
Sbjct: 246 ---GHVMASDGAAPRAGLAWSPCSRRQLLSLLSAGRARCVWDPPRPQPGSAGHPPDAQPG 302
Query: 484 LHYSMNEQCRFDFGLGYMMCTAFRT-FDPCKQLWC-SHPDNPYFCKTKKGPPLDGTMCAP 541
L+YS NEQCR FG + CT R D C+ L C + P + C P LDGT C
Sbjct: 303 LYYSANEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGV 362
Query: 542 GKHCFKGHC---IWLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGR 598
K C KG C + LTP I G W +W P CSR+CG GV R RQC+NP PA GGR
Sbjct: 363 EKWCSKGRCRSLVELTP-IAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGR 421
Query: 599 TCSGLAYDFQLCSRQDCPDSLADFREEQCRQWD---LYFEHGDAQ-HHW---LPHEHRDA 651
C G ++C+ Q C + +F +QC + D L G A +HW +PH DA
Sbjct: 422 ACVGADLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDA 481
Query: 652 KERCHLYCESRETGEVVSMKR--MVHDGTRC-----SYKDAFSLCVRGDCRKVGCDGVIG 704
C C R GE MKR DGTRC SLCV G CR GCDG +
Sbjct: 482 --LCRHMC--RAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMD 537
Query: 705 SSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSHHLA 764
S + D+C VCGGDNS C KG+FT + + Y+ + + I HLA
Sbjct: 538 SQQVWDRCQVCGGDNSTCSPRKGSFT-AGRAREYVTFLTVTPNLTSVYIANHRPLFTHLA 596
Query: 765 VKNLETGKFILNEENDVDASSKTFIAMGVEWEYRDEDGR---------------ETLQTM 809
V+ G++++ + K I+ + EDGR E ++
Sbjct: 597 VR--IGGRYVV--------AGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIW 646
Query: 810 GPLHGTITVLVI-PVGD-----TRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYEWALKKW 863
GPL + V G+ TR +T+ Y + + WA +
Sbjct: 647 GPLQEDADIQVYRRYGEEYGNLTRPDITFTYF-------------QPKPRQAWVWAAVR- 692
Query: 864 SPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEW 923
PCS CG G ++ Y C + ++V C +P A AC + C P W G++
Sbjct: 693 GPCSVSCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPC-PPYWAVGDF 751
Query: 924 EPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPE---SRRACSRELCPGRWR 980
PCS +CG G++ R VRC++ + +++ C + + C+ + CP RW
Sbjct: 752 GPCSASCG-GGLRERPVRCVE-AQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWE 809
Query: 981 AGPWSQCSVTCGNG 994
S C+ G G
Sbjct: 810 VSEPSSCTSAGGAG 823
Score = 74.7 bits (182), Expect = 5e-13
Identities = 56/176 (31%), Positives = 72/176 (40%), Gaps = 12/176 (6%)
Query: 862 KWSPCSKPCGGGSQFTKYGCRRRLDH----KMVHRGFCAALSKPKAIRRACNPQECSQPV 917
K + CS CG G C R +++ C L +P+ + AC+ + C P
Sbjct: 958 KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEP-QEACSLEPCP-PR 1015
Query: 918 WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCPG 977
W PCS +CG G RSV C+Q A RPE+ C C
Sbjct: 1016 WKVMSLGPCSASCG-LGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTY 1074
Query: 978 RWRAGPWSQCSVTCGNGTQERPVLC----RTADDSFGICQE-ERPETARTCRLGPC 1028
RW G W +CSV+CG+G Q R C A CQ +P T R C GPC
Sbjct: 1075 RWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1130
Score = 73.6 bits (179), Expect = 1e-12
Identities = 54/179 (30%), Positives = 72/179 (40%), Gaps = 16/179 (8%)
Query: 863 WSP----CSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVW 918
W+P CS CG G ++ C V C SKP + R C C P
Sbjct: 897 WTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPC--PAR 954
Query: 919 VTGEWEPCSQTCGRTGMQVRSVRCIQPL-HDNTTRSVHAKHCNDA-RPESRRACSRELCP 976
+ CS +CGR G+ R + C + D+ + C RPE + ACS E CP
Sbjct: 955 WQYKLAACSVSCGR-GVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCP 1013
Query: 977 GRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQEE-------RPETARTCRLGPC 1028
RW+ CS +CG GT R V C D + +E RPE + C + C
Sbjct: 1014 PRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADC 1072
Score = 52.8 bits (125), Expect = 2e-06
Identities = 46/123 (37%), Positives = 58/123 (47%), Gaps = 22/123 (17%)
Query: 923 WEP----CSQTCGRTGMQVRSVRCIQPLHDNTTR-SVHAKHCNDA-RPESRR-ACSRELC 975
W P CS +CGR M++R + C+ D+ R V + C A +P SRR C C
Sbjct: 897 WTPAAGSCSVSCGRGLMELRFL-CM----DSALRVPVQEELCGLASKPGSRREVCQAVPC 951
Query: 976 PGRWRAGPWSQCSVTCGNGTQERPVLCRTA---DDSFGI-----CQE-ERPETARTCRLG 1026
P RW+ + CSV+CG G R + C A DD I CQ RPE C L
Sbjct: 952 PARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLE 1010
Query: 1027 PCP 1029
PCP
Sbjct: 1011 PCP 1013
Score = 46.6 bits (109), Expect = 1e-04
Identities = 37/124 (29%), Positives = 52/124 (41%), Gaps = 9/124 (7%)
Query: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKM---VHRGFCAALSKPKAIRRACNPQECS 914
W + PCS CG G+ C +LD V CAAL +P+A C +C+
Sbjct: 1016 WKVMSLGPCSASCGLGTARRSVAC-VQLDQGQDVEVDEAACAALVRPEA-SVPCLIADCT 1073
Query: 915 QPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSREL 974
W G W CS +CG G+Q R C+ P + +H +P + R C
Sbjct: 1074 YR-WHVGTWMECSVSCG-DGIQRRRDTCLGPQAQAPVPADFCQHL--PKPVTVRGCWAGP 1129
Query: 975 CPGR 978
C G+
Sbjct: 1130 CVGQ 1133
Score = 34.7 bits (78), Expect = 0.57
Identities = 17/50 (34%), Positives = 20/50 (40%)
Query: 856 YEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIR 905
Y W + W CS CG G Q + C V FC L KP +R
Sbjct: 1074 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVR 1123
Score = 33.9 bits (76), Expect = 0.96
Identities = 28/76 (36%), Positives = 33/76 (43%), Gaps = 11/76 (14%)
Query: 941 RCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCP-----GRWRA-GPWSQCSVTCGNG 994
R + PL D T V K C+ R S EL P GRW + GP S CS +CG G
Sbjct: 349 RLLVPLLDGTECGVE-KWCSKGRCRSLV----ELTPIAAVHGRWSSWGPRSPCSRSCGGG 403
Query: 995 TQERPVLCRTADDSFG 1010
R C +FG
Sbjct: 404 VVTRRRQCNNPRPAFG 419
>gi|157427675 ADAM metallopeptidase with thrombospondin type 1
motif, 4 preproprotein [Homo sapiens]
Length = 837
Score = 331 bits (849), Expect = 2e-90
Identities = 249/765 (32%), Positives = 365/765 (47%), Gaps = 74/765 (9%)
Query: 105 PGS----HLFYNVTVFGRDLHLRLRPNARLVAPGATMEWQGEKGTTRVEPLLGSC----L 156
PGS L + FG L L L ++ + G T+++ G+ LLG
Sbjct: 73 PGSGAPARLLCRLQAFGETLLLELEQDSGVQVEGLTVQYLGQ-----APELLGGAEPGTY 127
Query: 157 YVGDVAGLAEASSVALSNCDG--LAGLIRMEEEEFFIEPLEKGLAAQEAEQGRVHVVYRR 214
G + G + SVA + DG L G+++ E ++PLE G G H++ R+
Sbjct: 128 LTGTING--DPESVASLHWDGGALLGVLQYRGAELHLQPLEGGTPNSAGGPG-AHILRRK 184
Query: 215 PPTSPPLGGPQALDTGASLDSLDSLSRALGVLEEHANSSRRRARRHAADDDYNIEVLLGV 274
P S GP ++ LG + RRA+R A+ + +E L+
Sbjct: 185 SPASGQ--GPMC-----------NVKAPLG----SPSPRPRRAKRFASLSRF-VETLVVA 226
Query: 275 DDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINVVLVRIILLSYGKSMSLIEIG- 333
DD + FHG +++YLLT+M + + S+ +++V+ R+++L G+ ++G
Sbjct: 227 DDKMAAFHGAG-LKRYLLTVMAAAAKAFKHPSIRNPVSLVVTRLVILGSGEEGP--QVGP 283
Query: 334 NPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDF---GPSGMQGYAPVTGMCHPVR 390
+ +Q+L + C W P+ ++ D AI TRQD G A V +C P R
Sbjct: 284 SAAQTLRSFCAWQRGLNTPEDSDPDHFDTAILFTRQDLCGVSTCDTLGMADVGTVCDPAR 343
Query: 391 SCTLNHEDGFSSAFVVAHETGHVLGMEHDGQGNRCGDEVRLGS---IMAPLVQAAFHRFH 447
SC + +DG SAF AHE GHV M HD L + +MAP++
Sbjct: 344 SCAIVEDDGLQSAFTAAHELGHVFNMLHDNSKPCISLNGPLSTSRHVMAPVMAHVDPEEP 403
Query: 448 WSRCSQQELSRYLHSY--DCLLDDPFAHDWPALP-QLPGLHYSMNEQCRFDFGLGYMMCT 504
WS CS + ++ +L + CLLD P A LP PG Y + QC+ FG C
Sbjct: 404 WSPCSARFITDFLDNGYGHCLLDKPEAP--LHLPVTFPGKDYDADRQCQLTFGPDSRHCP 461
Query: 505 AFRTFDPCKQLWCS-HPDNPYFCKTKKGPPLDGTMCAPGKHCFKGHCIW---LTPDILKR 560
PC LWCS H + C+TK P DGT C P + C G C+ L + +
Sbjct: 462 QLPP--PCAALWCSGHLNGHAMCQTKHSPWADGTPCGPAQACMGGRCLHMDQLQDFNIPQ 519
Query: 561 DGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCP-DSL 619
G WG W P+G CSRTCG GV+F +R C P P NGG+ C G F+ C+ +DCP S
Sbjct: 520 AGGWGPWGPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCPTGSA 579
Query: 620 ADFREEQCRQWDL---YFEHGDAQHHWLPHEHRDA-KERCHLYCESRETGEVVSMKRMVH 675
FREEQC ++ F+ W+P A +++C L C+++ G ++ V
Sbjct: 580 LTFREEQCAAYNHRTDLFKSFPGPMDWVPRYTGVAPQDQCKLTCQAQALGYYYVLEPRVV 639
Query: 676 DGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKK 735
DGT CS D+ S+CV+G C GCD +IGS K+ DKC VCGGD S C G+F + +
Sbjct: 640 DGTPCS-PDSSSVCVQGRCIHAGCDRIIGSKKKFDKCMVCGGDGSGCSKQSGSFRKF--R 696
Query: 736 HGYIKMFEIPAGARHLLIQEVDATSH---HLAVKNLETGKFILNEENDVDASSKTFIAMG 792
+GY + IPAGA H+L+++ H +LA+K L G + LN E + S + G
Sbjct: 697 YGYNNVVTIPAGATHILVRQQGNPGHRSIYLALK-LPDGSYALNGEYTLMPSPTDVVLPG 755
Query: 793 -VEWEYRDED-GRETLQTMGPLHGTITVLVIPVG---DTRVSLTY 832
V Y ETL GPL +T+ V+ G DTR+ ++
Sbjct: 756 AVSLRYSGATAASETLSGHGPLAQPLTLQVLVAGNPQDTRLRYSF 800
Score = 36.6 bits (83), Expect = 0.15
Identities = 22/73 (30%), Positives = 31/73 (42%), Gaps = 5/73 (6%)
Query: 863 WSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGE 922
W CS+ CGGG QF+ C R V R + R+CN ++C +T
Sbjct: 529 WGDCSRTCGGGVQFSSRDCTR-----PVPRNGGKYCEGRRTRFRSCNTEDCPTGSALTFR 583
Query: 923 WEPCSQTCGRTGM 935
E C+ RT +
Sbjct: 584 EEQCAAYNHRTDL 596
Score = 35.0 bits (79), Expect = 0.43
Identities = 21/56 (37%), Positives = 29/56 (51%), Gaps = 7/56 (12%)
Query: 921 GEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCP 976
G W CS+TCG G+Q S C +P+ N K+C + R R+C+ E CP
Sbjct: 527 GPWGDCSRTCG-GGVQFSSRDCTRPVPRN-----GGKYC-EGRRTRFRSCNTEDCP 575
Score = 34.7 bits (78), Expect = 0.57
Identities = 21/54 (38%), Positives = 23/54 (42%), Gaps = 3/54 (5%)
Query: 977 GRWRAGPWSQCSVTCGNGTQERPVLC-RTADDSFGICQEERPETARTCRLGPCP 1029
G W GPW CS TCG G Q C R + G E R R+C CP
Sbjct: 524 GPW--GPWGDCSRTCGGGVQFSSRDCTRPVPRNGGKYCEGRRTRFRSCNTEDCP 575
>gi|21265043 ADAM metallopeptidase with thrombospondin type 1 motif,
13 isoform 3 preproprotein [Homo sapiens]
Length = 1340
Score = 317 bits (812), Expect = 4e-86
Identities = 244/789 (30%), Positives = 348/789 (44%), Gaps = 112/789 (14%)
Query: 254 RRRARRHAADDDYNIEVLLGVDDSVVQFHGKEHVQKYLLTLMNIVNEIYHDESLGAHINV 313
+R+ +R AA ++E+L+ V V Q H +E ++Y+LT +NI E+ D SLGA V
Sbjct: 68 QRQRQRRAAGGILHLELLVAVGPDVFQAH-QEDTERYVLTNLNIGAELLRDPSLGAQFRV 126
Query: 314 VLVRIILLSYGKSMSLIEIGNPSQSLENVCRWAYLQQKPDTGHDEYHDHAIFLTRQDF-- 371
LV++++L+ + I N + SL +VC W+ D + D +++TR D
Sbjct: 127 HLVKMVILTEPEGAPNIT-ANLTSSLLSVCGWSQTINPEDDTDPGHADLVLYITRFDLEL 185
Query: 372 --GPSGMQGYAPVTGMCHPVRSCTLNHEDGFSSAFVVAHETGHVLGMEHDGQ-GNRCGDE 428
G ++G + G C P SC + + GF +AHE GH G+EHDG G+ CG
Sbjct: 186 PDGNRQVRGVTQLGGACSPTWSCLITEDTGFDLGVTIAHEIGHSFGLEHDGAPGSGCGPS 245
Query: 429 VRLGSIMAPLVQAAFHRFHWSRCSQQELSRYLHSYDCLLDDPFAHDWPALPQLPGLHYSM 488
G +MA A WS CS+++L L S
Sbjct: 246 ---GHVMASDGAAPRAGLAWSPCSRRQLLSLL--------------------------SA 276
Query: 489 NEQCRFDFGLGYMMCTAFRT-FDPCKQLWC-SHPDNPYFCKTKKGPPLDGTMCAPGKHCF 546
NEQCR FG + CT R D C+ L C + P + C P LDGT C K C
Sbjct: 277 NEQCRVAFGPKAVACTFAREHLDMCQALSCHTDPLDQSSCSRLLVPLLDGTECGVEKWCS 336
Query: 547 KGHC---IWLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGL 603
KG C + LTP I G W +W P CSR+CG GV R RQC+NP PA GGR C G
Sbjct: 337 KGRCRSLVELTP-IAAVHGRWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFGGRACVGA 395
Query: 604 AYDFQLCSRQDCPDSLADFREEQCRQWD---LYFEHGDAQ-HHW---LPHEHRDAKERCH 656
++C+ Q C + +F +QC + D L G A +HW +PH DA C
Sbjct: 396 DLQAEMCNTQACEKTQLEFMSQQCARTDGQPLRSSPGGASFYHWGAAVPHSQGDA--LCR 453
Query: 657 LYCESRETGEVVSMKR--MVHDGTRC-----SYKDAFSLCVRGDCRKVGCDGVIGSSKQE 709
C R GE MKR DGTRC SLCV G CR GCDG + S +
Sbjct: 454 HMC--RAIGESFIMKRGDSFLDGTRCMPSGPREDGTLSLCVSGSCRTFGCDGRMDSQQVW 511
Query: 710 DKCGVCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLE 769
D+C VCGGDNS C KG+FT + + Y+ + + I HLAV+
Sbjct: 512 DRCQVCGGDNSTCSPRKGSFT-AGRAREYVTFLTVTPNLTSVYIANHRPLFTHLAVR--I 568
Query: 770 TGKFILNEENDVDASSKTFIAMGVEWEYRDEDGR---------------ETLQTMGPLHG 814
G++++ + K I+ + EDGR E ++ GPL
Sbjct: 569 GGRYVV--------AGKMSISPNTTYPSLLEDGRVEYRVALTEDRLPRLEEIRIWGPLQE 620
Query: 815 TITVLVI-PVGD-----TRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYEWALKKWSPCSK 868
+ V G+ TR +T+ Y + + WA + PCS
Sbjct: 621 DADIQVYRRYGEEYGNLTRPDITFTYF-------------QPKPRQAWVWAAVR-GPCSV 666
Query: 869 PCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGEWEPCSQ 928
CG G ++ Y C + ++V C +P A AC + C P W G++ PCS
Sbjct: 667 SCGAGLRWVNYSCLDQARKELVETVQCQGSQQPPAWPEACVLEPC-PPYWAVGDFGPCSA 725
Query: 929 TCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPE---SRRACSRELCPGRWRAGPWS 985
+CG G++ R VRC++ + +++ C + + C+ + CP RW S
Sbjct: 726 SCG-GGLRERPVRCVE-AQGSLLKTLPPARCRAGAQQPAVALETCNPQPCPARWEVSEPS 783
Query: 986 QCSVTCGNG 994
C+ G G
Sbjct: 784 SCTSAGGAG 792
Score = 74.7 bits (182), Expect = 5e-13
Identities = 56/176 (31%), Positives = 72/176 (40%), Gaps = 12/176 (6%)
Query: 862 KWSPCSKPCGGGSQFTKYGCRRRLDH----KMVHRGFCAALSKPKAIRRACNPQECSQPV 917
K + CS CG G C R +++ C L +P+ + AC+ + C P
Sbjct: 927 KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEP-QEACSLEPCP-PR 984
Query: 918 WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCPG 977
W PCS +CG G RSV C+Q A RPE+ C C
Sbjct: 985 WKVMSLGPCSASCG-LGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADCTY 1043
Query: 978 RWRAGPWSQCSVTCGNGTQERPVLC----RTADDSFGICQE-ERPETARTCRLGPC 1028
RW G W +CSV+CG+G Q R C A CQ +P T R C GPC
Sbjct: 1044 RWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVRGCWAGPC 1099
Score = 73.6 bits (179), Expect = 1e-12
Identities = 54/179 (30%), Positives = 72/179 (40%), Gaps = 16/179 (8%)
Query: 863 WSP----CSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVW 918
W+P CS CG G ++ C V C SKP + R C C P
Sbjct: 866 WTPAAGSCSVSCGRGLMELRFLCMDSALRVPVQEELCGLASKPGSRREVCQAVPC--PAR 923
Query: 919 VTGEWEPCSQTCGRTGMQVRSVRCIQPL-HDNTTRSVHAKHCNDA-RPESRRACSRELCP 976
+ CS +CGR G+ R + C + D+ + C RPE + ACS E CP
Sbjct: 924 WQYKLAACSVSCGR-GVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLEPCP 982
Query: 977 GRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQEE-------RPETARTCRLGPC 1028
RW+ CS +CG GT R V C D + +E RPE + C + C
Sbjct: 983 PRWKVMSLGPCSASCGLGTARRSVACVQLDQGQDVEVDEAACAALVRPEASVPCLIADC 1041
Score = 52.8 bits (125), Expect = 2e-06
Identities = 46/123 (37%), Positives = 58/123 (47%), Gaps = 22/123 (17%)
Query: 923 WEP----CSQTCGRTGMQVRSVRCIQPLHDNTTR-SVHAKHCNDA-RPESRR-ACSRELC 975
W P CS +CGR M++R + C+ D+ R V + C A +P SRR C C
Sbjct: 866 WTPAAGSCSVSCGRGLMELRFL-CM----DSALRVPVQEELCGLASKPGSRREVCQAVPC 920
Query: 976 PGRWRAGPWSQCSVTCGNGTQERPVLCRTA---DDSFGI-----CQE-ERPETARTCRLG 1026
P RW+ + CSV+CG G R + C A DD I CQ RPE C L
Sbjct: 921 PARWQY-KLAACSVSCGRGVVRRILYCARAHGEDDGEEILLDTQCQGLPRPEPQEACSLE 979
Query: 1027 PCP 1029
PCP
Sbjct: 980 PCP 982
Score = 47.8 bits (112), Expect = 6e-05
Identities = 38/128 (29%), Positives = 53/128 (41%), Gaps = 9/128 (7%)
Query: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKM---VHRGFCAALSKPKAIRRACNPQECS 914
W + PCS CG G+ C +LD V CAAL +P+A C +C+
Sbjct: 985 WKVMSLGPCSASCGLGTARRSVAC-VQLDQGQDVEVDEAACAALVRPEA-SVPCLIADCT 1042
Query: 915 QPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSREL 974
W G W CS +CG G+Q R C+ P + +H +P + R C
Sbjct: 1043 YR-WHVGTWMECSVSCG-DGIQRRRDTCLGPQAQAPVPADFCQHL--PKPVTVRGCWAGP 1098
Query: 975 CPGRWRAG 982
C G+ G
Sbjct: 1099 CVGQGACG 1106
Score = 35.4 bits (80), Expect = 0.33
Identities = 42/154 (27%), Positives = 55/154 (35%), Gaps = 33/154 (21%)
Query: 863 WSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQPVWVTGE 922
WSPCS RR+L + C PKA+ + ++
Sbjct: 262 WSPCS--------------RRQLLSLLSANEQCRVAFGPKAVACTFAREHLDMCQALSCH 307
Query: 923 WEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRELCP-----G 977
+P Q+ R + PL D T V K C+ R S EL P G
Sbjct: 308 TDPLDQSS--------CSRLLVPLLDGTECGVE-KWCSKGRCRSLV----ELTPIAAVHG 354
Query: 978 RWRA-GPWSQCSVTCGNGTQERPVLCRTADDSFG 1010
RW + GP S CS +CG G R C +FG
Sbjct: 355 RWSSWGPRSPCSRSCGGGVVTRRRQCNNPRPAFG 388
Score = 34.7 bits (78), Expect = 0.57
Identities = 17/50 (34%), Positives = 20/50 (40%)
Query: 856 YEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIR 905
Y W + W CS CG G Q + C V FC L KP +R
Sbjct: 1043 YRWHVGTWMECSVSCGDGIQRRRDTCLGPQAQAPVPADFCQHLPKPVTVR 1092
>gi|145309328 papilin [Homo sapiens]
Length = 1251
Score = 225 bits (574), Expect = 2e-58
Identities = 157/485 (32%), Positives = 212/485 (43%), Gaps = 60/485 (12%)
Query: 555 PDILKRDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQD 614
P + ++ +WG WS + CSRTCG GV FR R C + +GG +C G A + C +
Sbjct: 20 PKVRRQSDTWGPWSQWSPCSRTCGGGVSFRERPCYSQR-RDGGSSCVGPARSHRSCRTES 78
Query: 615 CPDSLADFREEQCRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYCESRETGEVVSMKRMV 674
CPD DFR EQC ++D E ++ WLP+ A +C L C + + V
Sbjct: 79 CPDGARDFRAEQCAEFD-GAEFQGRRYRWLPYY--SAPNKCELNCIPKGENFYYKHREAV 135
Query: 675 HDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPK 734
DGT C +CV G CR VGCD + SSKQEDKC CGGD + C V GTF
Sbjct: 136 VDGTPCE-PGKRDVCVDGSCRVVGCDHELDSSKQEDKCLRCGGDGTTCYPVAGTF----- 189
Query: 735 KHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGVE 794
DA AVKN+ G++ LN ++A+ A +
Sbjct: 190 ----------------------DANDLSRAVKNVR-GEYYLNGHWTIEAARALPAASTIL 226
Query: 795 WEYRDEDG---RETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMIHEDSLNVDDNNVLEE 851
R +G E L GP + + +I + + Y+Y + L
Sbjct: 227 HYERGAEGDLAPERLHARGPTSEPLVIELIS-QEPNPGVHYEYHL-----------PLRR 274
Query: 852 DSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQ 911
S + W+ WS CS CGGG Q C +DH+ C +P A RR+CN
Sbjct: 275 PSPGFSWSHGSWSDCSAECGGGHQSRLVFC--TIDHEAYPDHMCQRQPRP-ADRRSCNLH 331
Query: 912 ECSQPV-WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCN--DARPESRR 968
C + W G W PCS +CG G Q RSV CI +V C +P + +
Sbjct: 332 PCPETKRWKAGPWAPCSASCG-GGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQ 390
Query: 969 ACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSF---GICQ-EERPETARTCR 1024
AC+ + C W PW +CSV+CG G ++R V CR S C E+RP C
Sbjct: 391 ACNLQRC-AAWSPEPWGECSVSCGVGVRKRSVTCRGERGSLLHTAACSLEDRPPLTEPCV 449
Query: 1025 LGPCP 1029
CP
Sbjct: 450 HEDCP 454
Score = 94.0 bits (232), Expect = 8e-19
Identities = 62/181 (34%), Positives = 77/181 (42%), Gaps = 18/181 (9%)
Query: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLD---HKMVHRGFCAAL-SKPKAIRRACNPQEC 913
W W+PCS CGGGSQ C + V CA L KP AI+ ACN Q C
Sbjct: 339 WKAGPWAPCSASCGGGSQSRSVYCISSDGAGIQEAVEEAECAGLPGKPPAIQ-ACNLQRC 397
Query: 914 SQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCN-DARPESRRACSR 972
+ W W CS +CG G++ RSV C +H C+ + RP C
Sbjct: 398 A--AWSPEPWGECSVSCG-VGVRKRSVTC----RGERGSLLHTAACSLEDRPPLTEPCVH 450
Query: 973 ELCP----GRWRAGPWSQCSVTCGNGTQERPVLCRTADDSF-GICQEERPETARTCRLGP 1027
E CP W G W CS +C +GT+ R V+C S G Q +P C P
Sbjct: 451 EDCPLLSDQAWHVGTWGLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKPVDVEPCNTQP 510
Query: 1028 C 1028
C
Sbjct: 511 C 511
Score = 31.6 bits (70), Expect = 4.8
Identities = 23/92 (25%), Positives = 37/92 (40%), Gaps = 17/92 (18%)
Query: 558 LKRDGSW--GAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDC 615
L D +W G W G CS++C +G + R C P++ G D + C+ Q C
Sbjct: 455 LLSDQAWHVGTW---GLCSKSCSSGTRRRQVICAIGPPSHCGSLQHSKPVDVEPCNTQPC 511
Query: 616 --PDSLADFREEQCRQWDLYFEHGDAQHHWLP 645
P + ++ H A + W+P
Sbjct: 512 HLPQEVPSMQD----------VHTPASNPWMP 533
>gi|154275767 ADAMTS-like 1 isoform 4 precursor [Homo sapiens]
Length = 1762
Score = 218 bits (554), Expect = 4e-56
Identities = 143/469 (30%), Positives = 213/469 (45%), Gaps = 63/469 (13%)
Query: 560 RDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSL 619
RDG W AW P+ CSRTCG G + R+C + ++C G ++ CS DCP
Sbjct: 32 RDGLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPPEA 85
Query: 620 ADFREEQCRQWDLYFEHGDAQHH-----WLPHEHRDAKERCHLYCESRETGEVVSMKRMV 674
DFR +QC H D +HH WLP + D C L C+++ T VV + V
Sbjct: 86 GDFRAQQCSA------HNDVKHHGQFYEWLPVSN-DPDNPCSLKCQAKGTTLVVELAPKV 138
Query: 675 HDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTF-TRSP 733
DGTRC Y ++ +C+ G C+ VGCD +GS+ +ED CGVC GD S C++V+G + ++
Sbjct: 139 LDGTRC-YTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLS 197
Query: 734 KKHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGV 793
+ IP G+RH+ + +L K L+ K EN + +S+ TF+
Sbjct: 198 ATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTK----GENSL-SSTGTFLVDNS 252
Query: 794 EWEYRDEDGRETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMIHEDSLNVDDNNVLEEDS 853
+++ +E L+ GPL V + G T +++ ++
Sbjct: 253 SVDFQKFPDKEILRMAGPLTADFIVKIRNSGS--ADSTVQFIFYQ--------------P 296
Query: 854 VVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALS---KPKAIRRACNP 910
+++ W + PCS CGGG Q T C +++V +C KPK + CN
Sbjct: 297 IIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNL 356
Query: 911 QECSQ----------------PVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSV 954
C P W W CS +CG G+Q R+V C++ SV
Sbjct: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCG-GGIQSRAVSCVEEDIQGHVTSV 415
Query: 955 HAKHC-NDARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLC 1002
C + + C+ CP +W A WS C+VTCG G + R VLC
Sbjct: 416 EEWKCMYTPKMPIAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLC 463
Score = 113 bits (282), Expect = 1e-24
Identities = 55/150 (36%), Positives = 77/150 (51%), Gaps = 7/150 (4%)
Query: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCA----ALSKPKAIRRACNPQEC 913
W + KWSPCS CG G Q C L +M A KP ++ ACN C
Sbjct: 670 WEIGKWSPCSLTCGVGLQTRDVFCSHLLSREMNETVILADELCRQPKPSTVQ-ACNRFNC 728
Query: 914 SQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRE 973
P W +W+PCS+TCG G+Q R V C Q + D + + C+ ++P ++AC ++
Sbjct: 729 P-PAWYPAQWQPCSRTCGG-GVQKREVLCKQRMADGSFLELPETFCSASKPACQQACKKD 786
Query: 974 LCPGRWRAGPWSQCSVTCGNGTQERPVLCR 1003
CP W W++CS +CG GTQ R +CR
Sbjct: 787 DCPSEWLLSDWTECSTSCGEGTQTRSAICR 816
Score = 85.1 bits (209), Expect = 4e-16
Identities = 56/233 (24%), Positives = 87/233 (37%), Gaps = 64/233 (27%)
Query: 857 EWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQEC--- 913
+W ++WSPC+ CG G ++ C +DH+ +H G C+ +KP P C
Sbjct: 439 KWLAQEWSPCTVTCGQGLRYRVVLC---IDHRGMHTGGCSPKTKPHIKEECIVPTPCYKP 495
Query: 914 --------------------------SQPVWVTGEWEPCSQTCGRTGMQVRSVRC-IQPL 946
+P ++ W C+ TCG G QVR VRC +
Sbjct: 496 KEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCG-VGTQVRIVRCQVLLS 554
Query: 947 HDNTTRSVHAKHCNDARPESRRACSRELCPGR------------------------WRAG 982
+ + C +P S+RAC C G W
Sbjct: 555 FSQSVADLPIDECEGPKPASQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYE 614
Query: 983 PWSQCSVTCGNGTQERPVLC------RTADDSFGICQEERPETARTCRLGPCP 1029
+++CS +CG G QE V C A+++ + P+ ++C L PCP
Sbjct: 615 GFTKCSESCGGGVQEAVVSCLNKQTREPAEENLCVTSRRPPQLLKSCNLDPCP 667
Score = 81.3 bits (199), Expect = 5e-15
Identities = 51/181 (28%), Positives = 78/181 (43%), Gaps = 14/181 (7%)
Query: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKM---VHRGFCAALSKPKAIRRACNPQECS 914
W + WS C++ CGGG Q + C++ + V C ++K +ACN Q C
Sbjct: 1549 WMVTSWSACTRSCGGGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQQLCV 1608
Query: 915 QPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDA-RPESRRACSRE 973
+ W W C+ C + V+ + D T + ++ C+ RP S + C E
Sbjct: 1609 E--WAFSSWGQCNGPCIGPHLAVQHRQVFCQTRDGIT--LPSEQCSALPRPVSTQNCWSE 1664
Query: 974 LCPGRWRAGPWSQCSVTCGN-GTQERPVLCRTADDSFGICQE-----ERPETARTCRLGP 1027
C WR W+ C+ TCGN G Q R V C A + + + RP + C + P
Sbjct: 1665 ACSVHWRVSLWTLCTATCGNYGFQSRRVECVHARTNKAVPEHLCSWGPRPANWQRCNITP 1724
Query: 1028 C 1028
C
Sbjct: 1725 C 1725
Score = 77.8 bits (190), Expect = 6e-14
Identities = 60/219 (27%), Positives = 83/219 (37%), Gaps = 51/219 (23%)
Query: 858 WALKKWSPCSKPCGGGSQFTKYGCRRR--LDHKMVHRGFCAALSKPKAIRRACNPQECSQ 915
W W+ CS CGGG Q C H + + I + CN +C
Sbjct: 380 WEATPWTACSSSCGGGIQSRAVSCVEEDIQGHVTSVEEWKCMYTPKMPIAQPCNIFDC-- 437
Query: 916 PVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCND-ARPESRRAC---- 970
P W+ EW PC+ TCG+ G++ R V CI R +H C+ +P + C
Sbjct: 438 PKWLAQEWSPCTVTCGQ-GLRYRVVLCIDH------RGMHTGGCSPKTKPHIKEECIVPT 490
Query: 971 --------------------SRELCPGR-------WRAGPWSQCSVTCGNGTQERPVLCR 1003
++EL G + WS C+VTCG GTQ R V C+
Sbjct: 491 PCYKPKEKLPVEAKLPWFKQAQELEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQ 550
Query: 1004 T--------ADDSFGICQEERPETARTCRLGPCPRNISD 1034
AD C+ +P + R C GPC I +
Sbjct: 551 VLLSFSQSVADLPIDECEGPKPASQRACYAGPCSGEIPE 589
Score = 75.5 bits (184), Expect = 3e-13
Identities = 61/220 (27%), Positives = 87/220 (39%), Gaps = 43/220 (19%)
Query: 849 LEEDSVVYE---WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGF-CAALSKPK-A 903
LEE + V E + + WS C+ CG G+Q C+ L PK A
Sbjct: 514 LEEGAAVSEEPSFIPEAWSACTVTCGVGTQVRIVRCQVLLSFSQSVADLPIDECEGPKPA 573
Query: 904 IRRACNPQECSQPV-----------------------WVTGEWEPCSQTCGRTGMQVRSV 940
+RAC CS + W + CS++CG G+Q V
Sbjct: 574 SQRACYAGPCSGEIPEFNPDETDGLFGGLQDFDELYDWEYEGFTKCSESCGG-GVQEAVV 632
Query: 941 RCIQPLHDNTTRSVHAKHCNDAR--PESRRACSRELCPGRWRAGPWSQCSVTCGNGTQER 998
C L+ T C +R P+ ++C+ + CP RW G WS CS+TCG G Q R
Sbjct: 633 SC---LNKQTREPAEENLCVTSRRPPQLLKSCNLDPCPARWEIGKWSPCSLTCGVGLQTR 689
Query: 999 PVLC---------RTADDSFGICQEERPETARTCRLGPCP 1029
V C T + +C++ +P T + C CP
Sbjct: 690 DVFCSHLLSREMNETVILADELCRQPKPSTVQACNRFNCP 729
Score = 72.8 bits (177), Expect = 2e-12
Identities = 47/157 (29%), Positives = 70/157 (44%), Gaps = 11/157 (7%)
Query: 856 YEWALKKWSPCSKPCGG-GSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECS 914
Y W++ + + CS CG G Q + C L+ V+ CA +P ACN ++C
Sbjct: 1489 YWWSVDRLATCSASCGNRGVQQPRLRCL--LNSTEVNPAHCAGKVRPAVQPIACNRRDCP 1546
Query: 915 QPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDA--RPESRRACSR 972
W+ W C+++CG G+Q R V C + + V C RP +AC++
Sbjct: 1547 SR-WMVTSWSACTRSCG-GGVQTRRVTCQKLKASGISTPVSNDMCTQVAKRPVDTQACNQ 1604
Query: 973 ELCPGRWRAGPWSQCSVTCGN---GTQERPVLCRTAD 1006
+LC W W QC+ C Q R V C+T D
Sbjct: 1605 QLCV-EWAFSSWGQCNGPCIGPHLAVQHRQVFCQTRD 1640
Score = 56.6 bits (135), Expect = 1e-07
Identities = 45/141 (31%), Positives = 59/141 (41%), Gaps = 26/141 (18%)
Query: 857 EWALKKWSPCSKPCGG---GSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQEC 913
EWA W C+ PC G Q + C+ R D + C+AL +P + + C + C
Sbjct: 1609 EWAFSSWGQCNGPCIGPHLAVQHRQVFCQTR-DGITLPSEQCSALPRPVSTQN-CWSEAC 1666
Query: 914 SQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSRE 973
S W W C+ TCG G Q R V C VHA+ N A PE
Sbjct: 1667 SVH-WRVSLWTLCTATCGNYGFQSRRVEC-----------VHAR-TNKAVPE-------H 1706
Query: 974 LCPGRWRAGPWSQCSVT-CGN 993
LC R W +C++T C N
Sbjct: 1707 LCSWGPRPANWQRCNITPCEN 1727
Score = 53.5 bits (127), Expect = 1e-06
Identities = 42/149 (28%), Positives = 63/149 (42%), Gaps = 37/149 (24%)
Query: 915 QPV---WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCN----DARPESR 967
QP+ W ++ PCS TCG G Q+ S C L N R V ++C+ + +P+ +
Sbjct: 295 QPIIHRWRETDFFPCSATCGG-GYQLTSAECYD-LRSN--RVVADQYCHYYPENIKPKPK 350
Query: 968 -RACSRELCPG-----------------RWRAGPWSQCSVTCGNGTQERPVLCRTADDSF 1009
+ C+ + CP RW A PW+ CS +CG G Q R V C D
Sbjct: 351 LQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQG 410
Query: 1010 GICQEE--------RPETARTCRLGPCPR 1030
+ E + A+ C + CP+
Sbjct: 411 HVTSVEEWKCMYTPKMPIAQPCNIFDCPK 439
Score = 38.5 bits (88), Expect = 0.039
Identities = 26/95 (27%), Positives = 40/95 (42%), Gaps = 4/95 (4%)
Query: 850 EEDSVVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLD---HKMVHRGFCAALSKPKAIRR 906
++D EW L W+ CS CG G+Q CR+ L +V+ C L +I R
Sbjct: 784 KKDDCPSEWLLSDWTECSTSCGEGTQTRSAICRKMLKTGLSTVVNSTLCPPLPFSSSI-R 842
Query: 907 ACNPQECSQPVWVTGEWEPCSQTCGRTGMQVRSVR 941
C C++P + + P + +Q R R
Sbjct: 843 PCMLATCARPGRPSTKHSPHIAAARKVYIQTRRQR 877
>gi|154275765 ADAMTS-like 1 isoform 2 precursor [Homo sapiens]
Length = 525
Score = 218 bits (554), Expect = 4e-56
Identities = 143/469 (30%), Positives = 213/469 (45%), Gaps = 63/469 (13%)
Query: 560 RDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSL 619
RDG W AW P+ CSRTCG G + R+C + ++C G ++ CS DCP
Sbjct: 32 RDGLWDAWGPWSECSRTCGGGASYSLRRCLS------SKSCEGRNIRYRTCSNVDCPPEA 85
Query: 620 ADFREEQCRQWDLYFEHGDAQHH-----WLPHEHRDAKERCHLYCESRETGEVVSMKRMV 674
DFR +QC H D +HH WLP + D C L C+++ T VV + V
Sbjct: 86 GDFRAQQCSA------HNDVKHHGQFYEWLPVSN-DPDNPCSLKCQAKGTTLVVELAPKV 138
Query: 675 HDGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTF-TRSP 733
DGTRC Y ++ +C+ G C+ VGCD +GS+ +ED CGVC GD S C++V+G + ++
Sbjct: 139 LDGTRC-YTESLDMCISGLCQIVGCDHQLGSTVKEDNCGVCNGDGSTCRLVRGQYKSQLS 197
Query: 734 KKHGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGV 793
+ IP G+RH+ + +L K L+ K EN + +S+ TF+
Sbjct: 198 ATKSDDTVVAIPYGSRHIRLVLKGPDHLYLETKTLQGTK----GENSL-SSTGTFLVDNS 252
Query: 794 EWEYRDEDGRETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMIHEDSLNVDDNNVLEEDS 853
+++ +E L+ GPL V + G T +++ ++
Sbjct: 253 SVDFQKFPDKEILRMAGPLTADFIVKIRNSGS--ADSTVQFIFYQ--------------P 296
Query: 854 VVYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALS---KPKAIRRACNP 910
+++ W + PCS CGGG Q T C +++V +C KPK + CN
Sbjct: 297 IIHRWRETDFFPCSATCGGGYQLTSAECYDLRSNRVVADQYCHYYPENIKPKPKLQECNL 356
Query: 911 QECSQ----------------PVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSV 954
C P W W CS +CG G+Q R+V C++ SV
Sbjct: 357 DPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCG-GGIQSRAVSCVEEDIQGHVTSV 415
Query: 955 HAKHC-NDARPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLC 1002
C + + C+ CP +W A WS C+VTCG G + R VLC
Sbjct: 416 EEWKCMYTPKMPIAQPCNIFDCP-KWLAQEWSPCTVTCGQGLRYRVVLC 463
Score = 53.5 bits (127), Expect = 1e-06
Identities = 42/149 (28%), Positives = 63/149 (42%), Gaps = 37/149 (24%)
Query: 915 QPV---WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCN----DARPESR 967
QP+ W ++ PCS TCG G Q+ S C L N R V ++C+ + +P+ +
Sbjct: 295 QPIIHRWRETDFFPCSATCGG-GYQLTSAECYD-LRSN--RVVADQYCHYYPENIKPKPK 350
Query: 968 -RACSRELCPG-----------------RWRAGPWSQCSVTCGNGTQERPVLCRTADDSF 1009
+ C+ + CP RW A PW+ CS +CG G Q R V C D
Sbjct: 351 LQECNLDPCPASDGYKQIMPYDLYHPLPRWEATPWTACSSSCGGGIQSRAVSCVEEDIQG 410
Query: 1010 GICQEE--------RPETARTCRLGPCPR 1030
+ E + A+ C + CP+
Sbjct: 411 HVTSVEEWKCMYTPKMPIAQPCNIFDCPK 439
Score = 45.4 bits (106), Expect = 3e-04
Identities = 19/60 (31%), Positives = 31/60 (51%), Gaps = 3/60 (5%)
Query: 857 EWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQP 916
+W ++WSPC+ CG G ++ C +DH+ +H G C+ +KP P C +P
Sbjct: 439 KWLAQEWSPCTVTCGQGLRYRVVLC---IDHRGMHTGGCSPKTKPHIKEECIVPTPCYKP 495
>gi|145275198 ADAMTS-like 3 precursor [Homo sapiens]
Length = 1691
Score = 199 bits (506), Expect = 1e-50
Identities = 138/465 (29%), Positives = 202/465 (43%), Gaps = 55/465 (11%)
Query: 560 RDGSWGAWSPFGSCSRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSL 619
+DG+W AW + CSRTCG G + R+C GR C G ++ CS DCP
Sbjct: 74 KDGNWDAWGDWSDCSRTCGGGASYSLRRCLT------GRNCEGQNIRYKTCSNHDCPPDA 127
Query: 620 ADFREEQCRQWDLYFEHGDAQHHWLPHEHRDAKERCHLYCESRETGEVVSMKRMVHDGTR 679
DFR +QC ++ G + WLP + D C L C ++ VV + V DGTR
Sbjct: 128 EDFRAQQCSAYNDVQYQGH-YYEWLPR-YNDPAAPCALKCHAQGQNLVVELAPKVLDGTR 185
Query: 680 CSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTR--SPKKHG 737
C+ D+ +C+ G C+ VGCD +GS+ +ED CGVC GD S C++V+G SP+K
Sbjct: 186 CN-TDSLDMCISGICQAVGCDRQLGSNAKEDNCGVCAGDGSTCRLVRGQSKSHVSPEKRE 244
Query: 738 YIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGVEWEY 797
+ +P G+R + I + K L+ K E+ + S F+ E+
Sbjct: 245 E-NVIAVPLGSRSVRITVKGPAHLFIESKTLQGSK----GEHSFN-SPGVFLVENTTVEF 298
Query: 798 RDEDGRETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMIHEDSLNVDDNNVLEEDSVVYE 857
+ R+T + GPL +Y +DS+ + ++
Sbjct: 299 QRGSERQTFKIPGPLMADFI------------FKTRYTAAKDSV----VQFFFYQPISHQ 342
Query: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALS---KPKAIRRACNPQECS 914
W + PC+ CGGG Q C ++V +C KPK + C+ C
Sbjct: 343 WRQTDFFPCTVTCGGGYQLNSAECVDIRLKRVVPDHYCHYYPENVKPKPKLKECSMDPCP 402
Query: 915 Q----------------PVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKH 958
P W W CS +CG G+Q RS C++ V
Sbjct: 403 SSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCG-GGIQRRSFVCVEESMHGEILQVEEWK 461
Query: 959 CNDA-RPESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLC 1002
C A +P+ + C+ CP +W A WSQC+VTCG G + R VLC
Sbjct: 462 CMYAPKPKVMQTCNLFDCP-KWIAMEWSQCTVTCGRGLRYRVVLC 505
Score = 93.6 bits (231), Expect = 1e-18
Identities = 55/152 (36%), Positives = 74/152 (48%), Gaps = 17/152 (11%)
Query: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAAL------SKPKAIRRACNPQ 911
W + W PCS CG G Q C +H G A KP A++ ACN
Sbjct: 707 WHVGSWGPCSATCGVGIQTRDVYC--------LHPGETPAPPEECRDEKPHALQ-ACNQF 757
Query: 912 ECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACS 971
+C P W EW+ CS+TCG G Q R V C Q L D + ++ + C + S ++C+
Sbjct: 758 DCP-PGWHIEEWQQCSRTCGG-GTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCA 815
Query: 972 RELCPGRWRAGPWSQCSVTCGNGTQERPVLCR 1003
R CP G WS+CSV+CG G Q R +C+
Sbjct: 816 RTDCPPHLAVGDWSKCSVSCGVGIQRRKQVCQ 847
Score = 78.6 bits (192), Expect = 3e-14
Identities = 67/246 (27%), Positives = 96/246 (39%), Gaps = 54/246 (21%)
Query: 858 WALKKWSPCSKPCGGGSQFTKYGCRRRLDH---KMVHRGFCAALSKPKAIRRACNPQECS 914
W WS CS CG G + C+R + ++V CA +P R+ C C
Sbjct: 1487 WFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLG-RKPCFGHPCV 1545
Query: 915 QPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDA-RPESRRACSRE 973
Q WEP ++ GR R+VR +Q H + +C+D RP RR C+
Sbjct: 1546 Q-------WEPGNRCPGRC--MGRAVR-MQQRHTACQHNSSDSNCDDRKRPTLRRNCTSG 1595
Query: 974 LCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGIC-----QEERPETARTCRLGP- 1027
C W GPW C+ CG G Q R V C + Q+++P + R C LGP
Sbjct: 1596 ACDVCWHTGPWKPCTAACGRGFQSRKVDCIHTRSCKPVAKRHCVQKKKPISWRHC-LGPS 1654
Query: 1028 CPRNISDPSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYCSIPGYNK 1087
C R+ +D + V+ L+ CS+ Y +
Sbjct: 1655 CDRDCTDTTHYCMFVKHLN--------------------------------LCSLDRYKQ 1682
Query: 1088 LCCKSC 1093
CC+SC
Sbjct: 1683 RCCQSC 1688
Score = 78.2 bits (191), Expect = 4e-14
Identities = 61/209 (29%), Positives = 84/209 (40%), Gaps = 32/209 (15%)
Query: 849 LEEDSVVYE---WALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGF----CAALSKP 901
LEE + E + + WS CS CG G Q + CR L C P
Sbjct: 556 LEETRIATEEPTFIPEPWSACSTTCGPGVQVREVKCRVLLTFTQTETELPEEECEGPKLP 615
Query: 902 K---AIRRACNPQECSQPVWV--------TGEWE-----PCSQTCGRTGMQVRSVRCIQP 945
+ AC+ S+ + + T +WE PC+ TC G Q C
Sbjct: 616 TERPCLLEACDESPASRELDIPLPEDSETTYDWEYAGFTPCTATCVG-GHQEAIAVC--- 671
Query: 946 LHDNTTRSVHAKHCNDAR--PESRRACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCR 1003
LH T ++V+ C+ P +AC+ E CP RW G W CS TCG G Q R V C
Sbjct: 672 LHIQTQQTVNDSLCDMVHRPPAMSQACNTEPCPPRWHVGSWGPCSATCGVGIQTRDVYCL 731
Query: 1004 TADDSFG---ICQEERPETARTCRLGPCP 1029
++ C++E+P + C CP
Sbjct: 732 HPGETPAPPEECRDEKPHALQACNQFDCP 760
Score = 66.6 bits (161), Expect = 1e-10
Identities = 37/129 (28%), Positives = 55/129 (42%), Gaps = 17/129 (13%)
Query: 910 PQECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESR-- 967
PQE P W G W CS TCG G +++ +C+ + ++ C+ +
Sbjct: 1423 PQE---PFWEPGNWSHCSATCGHLGARIQRPQCVMANGQEVSEAL----CDHLQKPLAGF 1475
Query: 968 RACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGI--------CQEERPET 1019
C+ CP RW WSQCSV+CG G R V C+ + + ++RP
Sbjct: 1476 EPCNIRDCPARWFTSVWSQCSVSCGEGYHSRQVTCKRTKANGTVQVVSPRACAPKDRPLG 1535
Query: 1020 ARTCRLGPC 1028
+ C PC
Sbjct: 1536 RKPCFGHPC 1544
Score = 59.7 bits (143), Expect = 2e-08
Identities = 43/152 (28%), Positives = 65/152 (42%), Gaps = 37/152 (24%)
Query: 915 QPV---WVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCN----DARPESR 967
QP+ W ++ PC+ TCG G Q+ S C+ R V +C+ + +P+ +
Sbjct: 337 QPISHQWRQTDFFPCTVTCGG-GYQLNSAECVDI---RLKRVVPDHYCHYYPENVKPKPK 392
Query: 968 -RACSRELCPG-----------------RWRAGPWSQCSVTCGNGTQERPVLCRTADDSF 1009
+ CS + CP RW PW+ CSV+CG G Q R +C
Sbjct: 393 LKECSMDPCPSSDGFKEIMPYDHFQPLPRWEHNPWTACSVSCGGGIQRRSFVCVEESMHG 452
Query: 1010 GICQEE--------RPETARTCRLGPCPRNIS 1033
I Q E +P+ +TC L CP+ I+
Sbjct: 453 EILQVEEWKCMYAPKPKVMQTCNLFDCPKWIA 484
Score = 37.7 bits (86), Expect = 0.067
Identities = 34/113 (30%), Positives = 43/113 (38%), Gaps = 13/113 (11%)
Query: 966 SRRACSRELCPGRWRA-GPWSQCSVTCGNGTQERPVLCRTADDSFG-------ICQEERP 1017
SR S E G W A G WS CS TCG G C T + G + P
Sbjct: 65 SRNTRSDEDKDGNWDAWGDWSDCSRTCGGGASYSLRRCLTGRNCEGQNIRYKTCSNHDCP 124
Query: 1018 ETARTCRLGPCPRNISDPSKKSYVVQWLSR-PDPDSPIRKISSKGHCQGDKSI 1069
A R C +D + + +WL R DP +P + K H QG +
Sbjct: 125 PDAEDFRAQQCSA-YNDVQYQGHYYEWLPRYNDPAAP---CALKCHAQGQNLV 173
Score = 35.8 bits (81), Expect = 0.25
Identities = 21/65 (32%), Positives = 29/65 (44%), Gaps = 5/65 (7%)
Query: 565 GAWSPFGSCSRTCGTGVKFRTRQCDNP--HPANGGRTCSGLAYDFQLCSRQDCPDSLADF 622
G+W P CS TCG G++ R C +P PA + Q C++ DCP
Sbjct: 710 GSWGP---CSATCGVGIQTRDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIE 766
Query: 623 REEQC 627
+QC
Sbjct: 767 EWQQC 771
Score = 32.0 bits (71), Expect = 3.7
Identities = 32/121 (26%), Positives = 41/121 (33%), Gaps = 35/121 (28%)
Query: 513 KQLWCSHPDN----PYFCKTKKGPPLDGTM---CAPGKHCFKGHCIWLTPDILKRDGSWG 565
+ ++C HP P C+ +K L C PG H +
Sbjct: 726 RDVYCLHPGETPAPPEECRDEKPHALQACNQFDCPPGWHIEE------------------ 767
Query: 566 AWSPFGSCSRTCGTGVKFRTRQC-----DNPHPANGGRTCSG-LAYDFQLCSRQDCPDSL 619
W CSRTCG G + R C D C G A + C+R DCP L
Sbjct: 768 -WQ---QCSRTCGGGTQNRRVTCRQLLTDGSFLNLSDELCQGPKASSHKSCARTDCPPHL 823
Query: 620 A 620
A
Sbjct: 824 A 824
>gi|94536854 thrombospondin, type I, domain containing 4 [Homo
sapiens]
Length = 1018
Score = 164 bits (414), Expect = 6e-40
Identities = 139/488 (28%), Positives = 209/488 (42%), Gaps = 50/488 (10%)
Query: 574 SRTCGTGVKFRTRQCDNPHPANGGRTCSGLAYDFQLCSRQDCPDSLADFREEQCRQWDLY 633
S G G T+ P + +C G ++LC+ CP+S RE QC ++
Sbjct: 266 SNNHGVGTHGATQSFSQPARSTA-ISCIGAYRQYKLCNTNVCPESSRSIREVQCASYNNK 324
Query: 634 FEHGDAQHHWLPHEHRDAKERCHLYCESRETGEVVSMKRMVHDGTRCSYKDAFSLCVRGD 693
G + W P +C L C++ V V DGT C ++ ++CV G
Sbjct: 325 PFMGRF-YEWEPFAEVKGNRKCELNCQAMGYRFYVRQAEKVIDGTPCD-QNGTAICVSGQ 382
Query: 694 CRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKKHGYIKMFEIPAGARHLLI 753
C+ +GCD +GS K DKCGVCGGDN+ C+VV G F + GY ++ EIP GA + I
Sbjct: 383 CKSIGCDDYLGSDKVVDKCGVCGGDNTGCQVVSGVFKHALTSLGYHRVVEIPEGATKINI 442
Query: 754 QEVDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGVEWEYR-----DEDGRETLQT 808
E+ ++++LA+++ +G+ I+N +D K + G + Y+ E+
Sbjct: 443 TEMYKSNNYLALRS-RSGRSIINGNWAIDRPGK-YEGGGTMFTYKRPNEISSTAGESFLA 500
Query: 809 MGPLHGTITVLVIPVGDTRVSLTYKYMI------------HEDSLNVDDNNVLEEDSVVY 856
GP + + V +I + Y+Y+I H + ++ E
Sbjct: 501 EGPTNEILDVYMIH-QQPNPGVHYEYVIMGTNAISPQVPPHRRPGEPFNGQMVTEGRSQE 559
Query: 857 EWALKKWSPCSKPCGGGS--QFTKYGCR----RRLDHKMVHRGFCAALSKPKAIRRACNP 910
E K + + G + FT + R D HR P+ RR+ +
Sbjct: 560 EGEQKGRNEEKEDLRGEAPEMFTSESAQTFPVRHPDRFSPHRPDNLVPPAPQPPRRSRDH 619
Query: 911 QECSQPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDA---RPESR 967
W CS TCG+ G Q RC+ H +T +C+ + PE
Sbjct: 620 N------WKQLGTTECSTTCGK-GSQYPIFRCV---HRSTHEEAPESYCDSSMKPTPE-E 668
Query: 968 RACSRELCPGRWRAGPWSQCSVTCGNGTQERPVLCRT--ADDSFGI----CQE-ERPETA 1020
C+ CP W G WS+CS TCG G Q R VLCR A+ S + CQ E+PET
Sbjct: 669 EPCNIFPCPAFWDIGEWSECSKTCGLGMQHRQVLCRQVYANRSLTVQPYRCQHLEKPETT 728
Query: 1021 RTCRLGPC 1028
TC+L C
Sbjct: 729 STCQLKIC 736
Score = 100 bits (250), Expect = 6e-21
Identities = 81/283 (28%), Positives = 119/283 (42%), Gaps = 52/283 (18%)
Query: 857 EWALKK-WSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQ 915
EW ++ W+ CS PCG G + C + +V C +P I C+ C++
Sbjct: 738 EWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGD-VVDDEECNMKLRPNDIEN-CDMGPCAK 795
Query: 916 PVWVTGEW-EPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDARPESRRACSREL 974
W EW E CS CG G++ RSV C+ N S+ + C + RP C
Sbjct: 796 S-WFLTEWSERCSAECG-AGVRTRSVVCMT----NHVSSLPLEGCGNNRPAEATPCDNGP 849
Query: 975 CPGR--WRAGPWSQCSVTCGNGTQERPVLC-RTADDSFGICQE------ERPETARTCRL 1025
C G+ W AG WSQCS+ CG+GTQ+R V+C R D+F + E+P + ++C L
Sbjct: 850 CTGKVEWFAGSWSQCSIECGSGTQQREVICVRKNADTFEVLDPSECSFLEKPPSQQSCHL 909
Query: 1026 GPC------------------------PRNISDPSKKSYVVQWLSRPD------PDSPIR 1055
PC R +SD S + +P+ P +
Sbjct: 910 KPCGAKWFSTEWSMCSKSCQGGFRVREVRCLSDDMTLSNLCDPQLKPEERESCNPQDCVP 969
Query: 1056 KISSKGHCQGDKSIFCRMEVLSRYCSIPGYNKLCCKSCNLYNN 1098
++ +C+ DK C + V +R C Y CC SC N
Sbjct: 970 EVDE--NCK-DKYYNCNVVVQARLCVYNYYKTACCASCTRVAN 1009
Score = 97.1 bits (240), Expect = 9e-20
Identities = 60/197 (30%), Positives = 85/197 (43%), Gaps = 15/197 (7%)
Query: 856 YEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQ 915
+ W + CS CG GSQ+ + C R H+ +C + KP CN C
Sbjct: 619 HNWKQLGTTECSTTCGKGSQYPIFRCVHRSTHEEAPESYCDSSMKPTPEEEPCNIFPC-P 677
Query: 916 PVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCND-ARPESRRACSREL 974
W GEW CS+TCG GMQ R V C Q ++ N + +V C +PE+ C ++
Sbjct: 678 AFWDIGEWSECSKTCG-LGMQHRQVLCRQ-VYANRSLTVQPYRCQHLEKPETTSTCQLKI 735
Query: 975 CPGRWRAGPWSQCSVTCGNGTQERPVLCRT----ADDSFGICQEERPETARTCRLGPCPR 1030
C W+ CSV CG G + R V C + D + RP C +GPC
Sbjct: 736 CSEWQIRTDWTSCSVPCGVGQRTRDVKCVSNIGDVVDDEECNMKLRPNDIENCDMGPC-- 793
Query: 1031 NISDPSKKSYVVQWLSR 1047
+K ++ +W R
Sbjct: 794 -----AKSWFLTEWSER 805
Score = 41.6 bits (96), Expect = 0.005
Identities = 15/27 (55%), Positives = 19/27 (70%)
Query: 562 GSWGAWSPFGSCSRTCGTGVKFRTRQC 588
G WGAW P+ +CSR+C GV +TR C
Sbjct: 54 GVWGAWGPWSACSRSCSGGVMEQTRPC 80
Score = 33.1 bits (74), Expect = 1.6
Identities = 17/32 (53%), Positives = 19/32 (59%), Gaps = 3/32 (9%)
Query: 976 PGRWRA-GPWSQCSVTCGNGTQE--RPVLCRT 1004
PG W A GPWS CS +C G E RP L R+
Sbjct: 53 PGVWGAWGPWSACSRSCSGGVMEQTRPCLPRS 84
>gi|223718260 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 157 bits (398), Expect = 4e-38
Identities = 97/286 (33%), Positives = 140/286 (48%), Gaps = 18/286 (6%)
Query: 564 WGAWSPFGSCSRTCGTGVKFRTRQCDNPH----PANGGRTCSGLAYDFQLCSRQDCPDSL 619
WG W+ + +CSR+CG GV + R C P G RTC+G + +QLC Q+CP
Sbjct: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
Query: 620 ADFREEQCRQWDLYFEHGDAQHHWLPHEHRD----AKERCHLYCESRETGEVVSMKRMVH 675
FREEQC ++ + +G H W P D + + C L+C + + + +
Sbjct: 110 RSFREEQCVSFNSHVYNGRT-HQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVP--AR 166
Query: 676 DGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKK 735
DGT C D +CV G C +GCDGV+ S+ DKCG+C GD S C V G + +
Sbjct: 167 DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAH 226
Query: 736 HGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGVEW 795
GY + IPAGAR + I E ++ LA+ + E G + N VD S K F G
Sbjct: 227 LGYSLVTHIPAGARDIQIVERKKSADVLALAD-EAGYYFFNGNYKVD-SPKNFNIAGTVV 284
Query: 796 EYRD-----EDGRETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMI 836
+YR E G E + GP + + V+V S+T++Y +
Sbjct: 285 KYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTL 330
Score = 105 bits (261), Expect = 3e-22
Identities = 63/182 (34%), Positives = 83/182 (45%), Gaps = 13/182 (7%)
Query: 855 VYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECS 914
+Y W L PCS C G + Y R D V +C AL++P+ + C +EC
Sbjct: 565 MYRWKLSSHEPCSATCTTGVM-SAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGREC- 622
Query: 915 QPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDA---RPESRRACS 971
QP W T W CS+TCG G Q R VRC + L SV++ C A RPE R+ C
Sbjct: 623 QPRWETSSWSECSRTCGE-GYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCR 681
Query: 972 RELCPGRWRAGPWSQCSVTCGNGTQERPVL---CRTADDSFGICQEERPETARTCRLGPC 1028
C +W WS+C+ CG ER V+ R ++D RP + C PC
Sbjct: 682 NPACGPQWEMSEWSECTAKCG----ERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPC 737
Query: 1029 PR 1030
R
Sbjct: 738 DR 739
Score = 103 bits (257), Expect = 1e-21
Identities = 69/239 (28%), Positives = 98/239 (41%), Gaps = 34/239 (14%)
Query: 857 EWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQP 916
+W + W PCS CG G C+ D ++V C +KP AI C + C
Sbjct: 740 QWTVSDWGPCSGSCGQGRTIRHVYCKTS-DGRVVPESQCQMETKPLAIH-PCGDKNCPAH 797
Query: 917 VWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDAR-PESRRACSRELC 975
W+ +WE C+ TCGR G++ R V C++ L + ++ C A+ P C C
Sbjct: 798 -WLAQDWERCNTTCGR-GVKKRLVLCME-LANGKPQTRSGPECGLAKKPPEESTCFERPC 854
Query: 976 PGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQE-ERPETARTCRLGPCPRNISD 1034
+W PWS+C+ TCG G + R V C D C +P + C L PCP
Sbjct: 855 -FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCP----- 908
Query: 1035 PSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYCSIPGYNKLCCKSC 1093
+ P DS CQ C + + C Y+K CC+SC
Sbjct: 909 -----------TEPPDDS----------CQDQPGTNCALAIKVNLCGHWYYSKACCRSC 946
Score = 91.3 bits (225), Expect = 5e-18
Identities = 65/226 (28%), Positives = 88/226 (38%), Gaps = 34/226 (15%)
Query: 826 TRVSLTYKYMIHEDSLNVDDN--NVLEEDSVVYE----------WALKKWSPCSKPCGGG 873
T V Y + D + VDD+ + L V+E W WS CS+ CG G
Sbjct: 582 TGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEG 641
Query: 874 SQFTKYGCRRRLD---HKMVHRGFCAALS--KPKAIRRACNPQECSQPVWVTGEWEPCSQ 928
QF C + L V+ C A +P+ R+ C C P W EW C+
Sbjct: 642 YQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEE-RKTCRNPACG-PQWEMSEWSECTA 699
Query: 929 TCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCN-DARPESRRACSRELCPGRWRAGPWSQC 987
CG + R +RC S K C+ + RP + C+ C +W W C
Sbjct: 700 KCGERSVVTRDIRC----------SEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPC 749
Query: 988 SVTCGNGTQERPVLCRTADDSF---GICQ-EERPETARTCRLGPCP 1029
S +CG G R V C+T+D CQ E +P C CP
Sbjct: 750 SGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCP 795
Score = 36.6 bits (83), Expect = 0.15
Identities = 21/58 (36%), Positives = 29/58 (50%), Gaps = 5/58 (8%)
Query: 856 YEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQEC 913
++W WS C+K CG G + C + D + RG C L KP R+AC+ Q C
Sbjct: 855 FKWYTSPWSECTKTCGVGVRMRDVKCYQGTD---IVRG-CDPLVKPVG-RQACDLQPC 907
Score = 35.4 bits (80), Expect = 0.33
Identities = 29/99 (29%), Positives = 37/99 (37%), Gaps = 25/99 (25%)
Query: 526 CKTKKGPPLDGTMCAPGKHCFKGHCI-WLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFR 584
C K PP + T CF+ C W T SP+ C++TCG GV+ R
Sbjct: 837 CGLAKKPPEEST-------CFERPCFKWYT-------------SPWSECTKTCGVGVRMR 876
Query: 585 TRQCDNPHPANGGRTCSGLAYDF--QLCSRQDCPDSLAD 621
+C + R C L Q C Q CP D
Sbjct: 877 DVKC--YQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPD 913
Score = 31.2 bits (69), Expect = 6.3
Identities = 24/77 (31%), Positives = 32/77 (41%), Gaps = 8/77 (10%)
Query: 842 NVDDNNVLE--EDSVVYEWA-LKKWSPCSKPCGGGSQFTKYGC--RRRLDHKMVHRGFCA 896
N +N LE D+ + W KW+ CS+ CGGG + C +RR C
Sbjct: 32 NSPTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCT 91
Query: 897 ALSKPKAIRRACNPQEC 913
SK + C QEC
Sbjct: 92 GTSKRYQL---CRVQEC 105
>gi|41281450 ADAMTS-like 2 precursor [Homo sapiens]
Length = 951
Score = 157 bits (398), Expect = 4e-38
Identities = 97/286 (33%), Positives = 140/286 (48%), Gaps = 18/286 (6%)
Query: 564 WGAWSPFGSCSRTCGTGVKFRTRQCDNPH----PANGGRTCSGLAYDFQLCSRQDCPDSL 619
WG W+ + +CSR+CG GV + R C P G RTC+G + +QLC Q+CP
Sbjct: 50 WGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCTGTSKRYQLCRVQECPPDG 109
Query: 620 ADFREEQCRQWDLYFEHGDAQHHWLPHEHRD----AKERCHLYCESRETGEVVSMKRMVH 675
FREEQC ++ + +G H W P D + + C L+C + + + +
Sbjct: 110 RSFREEQCVSFNSHVYNGRT-HQWKPLYPDDYVHISSKPCDLHCTTVDGQRQLMVP--AR 166
Query: 676 DGTRCSYKDAFSLCVRGDCRKVGCDGVIGSSKQEDKCGVCGGDNSHCKVVKGTFTRSPKK 735
DGT C D +CV G C +GCDGV+ S+ DKCG+C GD S C V G + +
Sbjct: 167 DGTSCKLTDLRGVCVSGKCEPIGCDGVLFSTHTLDKCGICQGDGSSCTHVTGNYRKGNAH 226
Query: 736 HGYIKMFEIPAGARHLLIQEVDATSHHLAVKNLETGKFILNEENDVDASSKTFIAMGVEW 795
GY + IPAGAR + I E ++ LA+ + E G + N VD S K F G
Sbjct: 227 LGYSLVTHIPAGARDIQIVERKKSADVLALAD-EAGYYFFNGNYKVD-SPKNFNIAGTVV 284
Query: 796 EYRD-----EDGRETLQTMGPLHGTITVLVIPVGDTRVSLTYKYMI 836
+YR E G E + GP + + V+V S+T++Y +
Sbjct: 285 KYRRPMDVYETGIEYIVAQGPTNQGLNVMVWNQNGKSPSITFEYTL 330
Score = 105 bits (261), Expect = 3e-22
Identities = 63/182 (34%), Positives = 83/182 (45%), Gaps = 13/182 (7%)
Query: 855 VYEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECS 914
+Y W L PCS C G + Y R D V +C AL++P+ + C +EC
Sbjct: 565 MYRWKLSSHEPCSATCTTGVM-SAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGREC- 622
Query: 915 QPVWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDA---RPESRRACS 971
QP W T W CS+TCG G Q R VRC + L SV++ C A RPE R+ C
Sbjct: 623 QPRWETSSWSECSRTCGE-GYQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEERKTCR 681
Query: 972 RELCPGRWRAGPWSQCSVTCGNGTQERPVL---CRTADDSFGICQEERPETARTCRLGPC 1028
C +W WS+C+ CG ER V+ R ++D RP + C PC
Sbjct: 682 NPACGPQWEMSEWSECTAKCG----ERSVVTRDIRCSEDEKLCDPNTRPVGEKNCTGPPC 737
Query: 1029 PR 1030
R
Sbjct: 738 DR 739
Score = 103 bits (257), Expect = 1e-21
Identities = 69/239 (28%), Positives = 98/239 (41%), Gaps = 34/239 (14%)
Query: 857 EWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQECSQP 916
+W + W PCS CG G C+ D ++V C +KP AI C + C
Sbjct: 740 QWTVSDWGPCSGSCGQGRTIRHVYCKTS-DGRVVPESQCQMETKPLAIH-PCGDKNCPAH 797
Query: 917 VWVTGEWEPCSQTCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCNDAR-PESRRACSRELC 975
W+ +WE C+ TCGR G++ R V C++ L + ++ C A+ P C C
Sbjct: 798 -WLAQDWERCNTTCGR-GVKKRLVLCME-LANGKPQTRSGPECGLAKKPPEESTCFERPC 854
Query: 976 PGRWRAGPWSQCSVTCGNGTQERPVLCRTADDSFGICQE-ERPETARTCRLGPCPRNISD 1034
+W PWS+C+ TCG G + R V C D C +P + C L PCP
Sbjct: 855 -FKWYTSPWSECTKTCGVGVRMRDVKCYQGTDIVRGCDPLVKPVGRQACDLQPCP----- 908
Query: 1035 PSKKSYVVQWLSRPDPDSPIRKISSKGHCQGDKSIFCRMEVLSRYCSIPGYNKLCCKSC 1093
+ P DS CQ C + + C Y+K CC+SC
Sbjct: 909 -----------TEPPDDS----------CQDQPGTNCALAIKVNLCGHWYYSKACCRSC 946
Score = 91.3 bits (225), Expect = 5e-18
Identities = 65/226 (28%), Positives = 88/226 (38%), Gaps = 34/226 (15%)
Query: 826 TRVSLTYKYMIHEDSLNVDDN--NVLEEDSVVYE----------WALKKWSPCSKPCGGG 873
T V Y + D + VDD+ + L V+E W WS CS+ CG G
Sbjct: 582 TGVMSAYAMCVRYDGVEVDDSYCDALTRPEPVHEFCAGRECQPRWETSSWSECSRTCGEG 641
Query: 874 SQFTKYGCRRRLD---HKMVHRGFCAALS--KPKAIRRACNPQECSQPVWVTGEWEPCSQ 928
QF C + L V+ C A +P+ R+ C C P W EW C+
Sbjct: 642 YQFRVVRCWKMLSPGFDSSVYSDLCEAAEAVRPEE-RKTCRNPACG-PQWEMSEWSECTA 699
Query: 929 TCGRTGMQVRSVRCIQPLHDNTTRSVHAKHCN-DARPESRRACSRELCPGRWRAGPWSQC 987
CG + R +RC S K C+ + RP + C+ C +W W C
Sbjct: 700 KCGERSVVTRDIRC----------SEDEKLCDPNTRPVGEKNCTGPPCDRQWTVSDWGPC 749
Query: 988 SVTCGNGTQERPVLCRTADDSF---GICQ-EERPETARTCRLGPCP 1029
S +CG G R V C+T+D CQ E +P C CP
Sbjct: 750 SGSCGQGRTIRHVYCKTSDGRVVPESQCQMETKPLAIHPCGDKNCP 795
Score = 36.6 bits (83), Expect = 0.15
Identities = 21/58 (36%), Positives = 29/58 (50%), Gaps = 5/58 (8%)
Query: 856 YEWALKKWSPCSKPCGGGSQFTKYGCRRRLDHKMVHRGFCAALSKPKAIRRACNPQEC 913
++W WS C+K CG G + C + D + RG C L KP R+AC+ Q C
Sbjct: 855 FKWYTSPWSECTKTCGVGVRMRDVKCYQGTD---IVRG-CDPLVKPVG-RQACDLQPC 907
Score = 35.4 bits (80), Expect = 0.33
Identities = 29/99 (29%), Positives = 37/99 (37%), Gaps = 25/99 (25%)
Query: 526 CKTKKGPPLDGTMCAPGKHCFKGHCI-WLTPDILKRDGSWGAWSPFGSCSRTCGTGVKFR 584
C K PP + T CF+ C W T SP+ C++TCG GV+ R
Sbjct: 837 CGLAKKPPEEST-------CFERPCFKWYT-------------SPWSECTKTCGVGVRMR 876
Query: 585 TRQCDNPHPANGGRTCSGLAYDF--QLCSRQDCPDSLAD 621
+C + R C L Q C Q CP D
Sbjct: 877 DVKC--YQGTDIVRGCDPLVKPVGRQACDLQPCPTEPPD 913
Score = 31.2 bits (69), Expect = 6.3
Identities = 24/77 (31%), Positives = 32/77 (41%), Gaps = 8/77 (10%)
Query: 842 NVDDNNVLE--EDSVVYEWA-LKKWSPCSKPCGGGSQFTKYGC--RRRLDHKMVHRGFCA 896
N +N LE D+ + W KW+ CS+ CGGG + C +RR C
Sbjct: 32 NSPTSNSLEGGTDATAFWWGEWTKWTACSRSCGGGVTSQERHCLQQRRKSVPGPGNRTCT 91
Query: 897 ALSKPKAIRRACNPQEC 913
SK + C QEC
Sbjct: 92 GTSKRYQL---CRVQEC 105
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.320 0.137 0.442
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 57,523,939
Number of Sequences: 37866
Number of extensions: 3143029
Number of successful extensions: 19179
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 146
Number of HSP's successfully gapped in prelim test: 165
Number of HSP's that attempted gapping in prelim test: 15521
Number of HSP's gapped (non-prelim): 2347
length of query: 1211
length of database: 18,247,518
effective HSP length: 114
effective length of query: 1097
effective length of database: 13,930,794
effective search space: 15282081018
effective search space used: 15282081018
T: 11
A: 40
X1: 16 ( 7.4 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.8 bits)
S2: 68 (30.8 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.