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Search of human proteins with 169167211
BLASTP 2.2.11 [Jun-05-2005]
Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer,
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997),
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs", Nucleic Acids Res. 25:3389-3402.
Query= gi|169167211 PREDICTED: FRAS1 related extracellular matrix 3
[Homo sapiens]
(2139 letters)
Database: hs.faa
37,866 sequences; 18,247,518 total letters
Searching..................................................done
Score E
Sequences producing significant alignments: (bits) Value
gi|169167211 PREDICTED: FRAS1 related extracellular matrix 3 [Ho... 4291 0.0
gi|169166904 PREDICTED: FRAS1 related extracellular matrix 3 [Ho... 4291 0.0
gi|169166334 PREDICTED: FRAS1 related extracellular matrix 3 [Ho... 4289 0.0
gi|79749430 FRAS1-related extracellular matrix protein 2 precurs... 2383 0.0
gi|122056683 FRAS1 related extracellular matrix 1 [Homo sapiens] 852 0.0
gi|108773804 Fraser syndrome 1 [Homo sapiens] 676 0.0
gi|47419930 chondroitin sulfate proteoglycan 4 [Homo sapiens] 203 2e-51
gi|10863913 solute carrier family 8 (sodium/calcium exchanger), ... 75 7e-13
gi|163914369 solute carrier family 8 (sodium/calcium exchanger),... 75 7e-13
gi|163914373 solute carrier family 8 (sodium/calcium exchanger),... 74 1e-12
gi|163914371 solute carrier family 8 (sodium/calcium exchanger),... 72 6e-12
gi|17865805 solute carrier family 8 (sodium/calcium exchanger), ... 70 2e-11
gi|33946304 solute carrier family 8 (sodium/calcium exchanger), ... 70 2e-11
gi|33946311 solute carrier family 8 (sodium/calcium exchanger), ... 70 2e-11
gi|15147254 solute carrier family 8 (sodium/calcium exchanger), ... 68 1e-10
gi|57163987 solute carrier family 8 member 2 [Homo sapiens] 64 2e-09
gi|113722120 G protein-coupled receptor 98 precursor [Homo sapiens] 59 7e-08
gi|54607027 integrin beta 4 isoform 2 precursor [Homo sapiens] 45 6e-04
gi|54607035 integrin beta 4 isoform 1 precursor [Homo sapiens] 45 6e-04
gi|54607033 integrin beta 4 isoform 3 precursor [Homo sapiens] 45 6e-04
gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapi... 44 0.002
gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sap... 44 0.002
gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapi... 44 0.002
gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapi... 44 0.002
gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapi... 44 0.002
gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapi... 44 0.002
gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapi... 44 0.002
gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapi... 44 0.002
gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapi... 44 0.002
gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapi... 44 0.002
>gi|169167211 PREDICTED: FRAS1 related extracellular matrix 3 [Homo
sapiens]
Length = 2139
Score = 4291 bits (11129), Expect = 0.0
Identities = 2139/2139 (100%), Positives = 2139/2139 (100%)
Query: 1 MAGASRHPTGTPRQLLVALACLLLSRPALQGRASSLGTEPDPALYLPARGALDGTRPDGP 60
MAGASRHPTGTPRQLLVALACLLLSRPALQGRASSLGTEPDPALYLPARGALDGTRPDGP
Sbjct: 1 MAGASRHPTGTPRQLLVALACLLLSRPALQGRASSLGTEPDPALYLPARGALDGTRPDGP 60
Query: 61 SVLIANPGLRVPLGRSLWLDPLRDLVIGVQPGDRCEVTVLDALPRLKGALSPRRFPCTFG 120
SVLIANPGLRVPLGRSLWLDPLRDLVIGVQPGDRCEVTVLDALPRLKGALSPRRFPCTFG
Sbjct: 61 SVLIANPGLRVPLGRSLWLDPLRDLVIGVQPGDRCEVTVLDALPRLKGALSPRRFPCTFG 120
Query: 121 PRQVQYTHFGSHSPGRARVLLQLRYDAPTHTLVLPFTLAVDLVFSQLELVTRNRPLVVEK 180
PRQVQYTHFGSHSPGRARVLLQLRYDAPTHTLVLPFTLAVDLVFSQLELVTRNRPLVVEK
Sbjct: 121 PRQVQYTHFGSHSPGRARVLLQLRYDAPTHTLVLPFTLAVDLVFSQLELVTRNRPLVVEK 180
Query: 181 LRSWSRAIDRRVLDFASLKSGATATRRCRLTPLPHEDGPLPKYGRLVDAVGAPLPRGKGV 240
LRSWSRAIDRRVLDFASLKSGATATRRCRLTPLPHEDGPLPKYGRLVDAVGAPLPRGKGV
Sbjct: 181 LRSWSRAIDRRVLDFASLKSGATATRRCRLTPLPHEDGPLPKYGRLVDAVGAPLPRGKGV 240
Query: 241 DCEAFLRAGVRYQHTATSSPNRDYVPMMVELLGPEGQDAGSAGVLVREHFQLLVRIRGGA 300
DCEAFLRAGVRYQHTATSSPNRDYVPMMVELLGPEGQDAGSAGVLVREHFQLLVRIRGGA
Sbjct: 241 DCEAFLRAGVRYQHTATSSPNRDYVPMMVELLGPEGQDAGSAGVLVREHFQLLVRIRGGA 300
Query: 301 ENTPPRPSFMATMMMEVDPLVLTALTPDALAAEDVESDPGDLVFNILNAPTHPPGHPGQQ 360
ENTPPRPSFMATMMMEVDPLVLTALTPDALAAEDVESDPGDLVFNILNAPTHPPGHPGQQ
Sbjct: 301 ENTPPRPSFMATMMMEVDPLVLTALTPDALAAEDVESDPGDLVFNILNAPTHPPGHPGQQ 360
Query: 361 GYVVSTDDPLGLPVSFFTQQELRELKIAYQPPAENSHGERLFQLELEVVDGDGAASDPFA 420
GYVVSTDDPLGLPVSFFTQQELRELKIAYQPPAENSHGERLFQLELEVVDGDGAASDPFA
Sbjct: 361 GYVVSTDDPLGLPVSFFTQQELRELKIAYQPPAENSHGERLFQLELEVVDGDGAASDPFA 420
Query: 421 FMVTVKSMNTLVPVASHNRGLVLFEGQSRPLSSTHSIPISDKDNLEEVKMAAVRGLRHGQ 480
FMVTVKSMNTLVPVASHNRGLVLFEGQSRPLSSTHSIPISDKDNLEEVKMAAVRGLRHGQ
Sbjct: 421 FMVTVKSMNTLVPVASHNRGLVLFEGQSRPLSSTHSIPISDKDNLEEVKMAAVRGLRHGQ 480
Query: 481 LVVFGAPAGCKYFTPADLAAGRVVYQHDGSNTYSDNIIFRMEDGHHQVDFLFPLTILPVD 540
LVVFGAPAGCKYFTPADLAAGRVVYQHDGSNTYSDNIIFRMEDGHHQVDFLFPLTILPVD
Sbjct: 481 LVVFGAPAGCKYFTPADLAAGRVVYQHDGSNTYSDNIIFRMEDGHHQVDFLFPLTILPVD 540
Query: 541 DEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQPLKGNEEEPQWELA 600
DEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQPLKGNEEEPQWELA
Sbjct: 541 DEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQPLKGNEEEPQWELA 600
Query: 601 PGSSHSGHYLGDLLLQQAELPLSTEDEDWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHL 660
PGSSHSGHYLGDLLLQQAELPLSTEDEDWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHL
Sbjct: 601 PGSSHSGHYLGDLLLQQAELPLSTEDEDWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHL 660
Query: 661 GPHSPQSVMVQLAFHVQDDHDPPNLSKQHIFTIKVQPVDILSPQLYPGTTLEMTVQEYQL 720
GPHSPQSVMVQLAFHVQDDHDPPNLSKQHIFTIKVQPVDILSPQLYPGTTLEMTVQEYQL
Sbjct: 661 GPHSPQSVMVQLAFHVQDDHDPPNLSKQHIFTIKVQPVDILSPQLYPGTTLEMTVQEYQL 720
Query: 721 THFQKNFLRYIDQDSDDQNLWYTLLTLPTDTDGNHQVRAGEIVLTDSPDTLIMHFTQAQV 780
THFQKNFLRYIDQDSDDQNLWYTLLTLPTDTDGNHQVRAGEIVLTDSPDTLIMHFTQAQV
Sbjct: 721 THFQKNFLRYIDQDSDDQNLWYTLLTLPTDTDGNHQVRAGEIVLTDSPDTLIMHFTQAQV 780
Query: 781 NQHKVAYQPPQKLGIAPRVVQFTYQVEDAAGNSVPGTFTLFLQPVDNQPPEVTNRGFAIL 840
NQHKVAYQPPQKLGIAPRVVQFTYQVEDAAGNSVPGTFTLFLQPVDNQPPEVTNRGFAIL
Sbjct: 781 NQHKVAYQPPQKLGIAPRVVQFTYQVEDAAGNSVPGTFTLFLQPVDNQPPEVTNRGFAIL 840
Query: 841 EGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQYFKRCMVPGESFMQADVINGSV 900
EGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQYFKRCMVPGESFMQADVINGSV
Sbjct: 841 EGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQYFKRCMVPGESFMQADVINGSV 900
Query: 901 SYQHGRDQTTTSDTFHLEVSDGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVL 960
SYQHGRDQTTTSDTFHLEVSDGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVL
Sbjct: 901 SYQHGRDQTTTSDTFHLEVSDGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVL 960
Query: 961 ENKATEITMGVIHGKRKDVGDLMLSFIVKDSPKLGTILVNGLPTERFTQEDLINGRVAYA 1020
ENKATEITMGVIHGKRKDVGDLMLSFIVKDSPKLGTILVNGLPTERFTQEDLINGRVAYA
Sbjct: 961 ENKATEITMGVIHGKRKDVGDLMLSFIVKDSPKLGTILVNGLPTERFTQEDLINGRVAYA 1020
Query: 1021 HTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVLVGESFIV 1080
HTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVLVGESFIV
Sbjct: 1021 HTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVLVGESFIV 1080
Query: 1081 YEGEKNSLTLQHLHVEDVDTHQDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFS 1140
YEGEKNSLTLQHLHVEDVDTHQDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFS
Sbjct: 1081 YEGEKNSLTLQHLHVEDVDTHQDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFS 1140
Query: 1141 LRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHE 1200
LRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHE
Sbjct: 1141 LRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHE 1200
Query: 1201 FKVLEGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRIIQQLATGSQPIHSFTLKEI 1260
FKVLEGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRIIQQLATGSQPIHSFTLKEI
Sbjct: 1201 FKVLEGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRIIQQLATGSQPIHSFTLKEI 1260
Query: 1261 QEASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHLTVNNGLKVEKG 1320
QEASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHLTVNNGLKVEKG
Sbjct: 1261 QEASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHLTVNNGLKVEKG 1320
Query: 1321 HSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEI 1380
HSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEI
Sbjct: 1321 HSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEI 1380
Query: 1381 NRGLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEVISKRITLIEGA 1440
NRGLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEVISKRITLIEGA
Sbjct: 1381 NRGLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEVISKRITLIEGA 1440
Query: 1441 RVTLTNNLLTNSDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQLQLASNKISYVH 1500
RVTLTNNLLTNSDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQLQLASNKISYVH
Sbjct: 1441 RVTLTNNLLTNSDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQLQLASNKISYVH 1500
Query: 1501 TSNDEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKKPILTIHRLTLQKEDSQLITLLEL 1560
TSNDEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKKPILTIHRLTLQKEDSQLITLLEL
Sbjct: 1501 TSNDEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKKPILTIHRLTLQKEDSQLITLLEL 1560
Query: 1561 TVEDSDTPDDLILFTITQVPMHGKILYNGSRPVTTFTKQDLNKNLISYKHDGSETTEDSF 1620
TVEDSDTPDDLILFTITQVPMHGKILYNGSRPVTTFTKQDLNKNLISYKHDGSETTEDSF
Sbjct: 1561 TVEDSDTPDDLILFTITQVPMHGKILYNGSRPVTTFTKQDLNKNLISYKHDGSETTEDSF 1620
Query: 1621 SLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKRLHTGHMG 1680
SLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKRLHTGHMG
Sbjct: 1621 SLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKRLHTGHMG 1680
Query: 1681 FLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGNQSTRVFTQADIDEMKISYVL 1740
FLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGNQSTRVFTQADIDEMKISYVL
Sbjct: 1681 FLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGNQSTRVFTQADIDEMKISYVL 1740
Query: 1741 NEGSNASKDIFYFSVEDNGGNKLTNQPFHLNWAWICLEKEYYIVDEDSTFLEVTLTRRGY 1800
NEGSNASKDIFYFSVEDNGGNKLTNQPFHLNWAWICLEKEYYIVDEDSTFLEVTLTRRGY
Sbjct: 1741 NEGSNASKDIFYFSVEDNGGNKLTNQPFHLNWAWICLEKEYYIVDEDSTFLEVTLTRRGY 1800
Query: 1801 LGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWRVRIIPDNEYETSETFQII 1860
LGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWRVRIIPDNEYETSETFQII
Sbjct: 1801 LGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWRVRIIPDNEYETSETFQII 1860
Query: 1861 LSEPLMAVLEFPEMATVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELIV 1920
LSEPLMAVLEFPEMATVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELIV
Sbjct: 1861 LSEPLMAVLEFPEMATVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELIV 1920
Query: 1921 ICSTRQGSATGTISSTVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESF 1980
ICSTRQGSATGTISSTVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESF
Sbjct: 1921 ICSTRQGSATGTISSTVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESF 1980
Query: 1981 SVSLRLPVGGQLGARFPTTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDL 2040
SVSLRLPVGGQLGARFPTTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDL
Sbjct: 1981 SVSLRLPVGGQLGARFPTTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDL 2040
Query: 2041 SQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEK 2100
SQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEK
Sbjct: 2041 SQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEK 2100
Query: 2101 FELLLQMPMGAVLGEPNKTTIFIEDTITDCKQSACSSFD 2139
FELLLQMPMGAVLGEPNKTTIFIEDTITDCKQSACSSFD
Sbjct: 2101 FELLLQMPMGAVLGEPNKTTIFIEDTITDCKQSACSSFD 2139
>gi|169166904 PREDICTED: FRAS1 related extracellular matrix 3 [Homo
sapiens]
Length = 2139
Score = 4291 bits (11129), Expect = 0.0
Identities = 2139/2139 (100%), Positives = 2139/2139 (100%)
Query: 1 MAGASRHPTGTPRQLLVALACLLLSRPALQGRASSLGTEPDPALYLPARGALDGTRPDGP 60
MAGASRHPTGTPRQLLVALACLLLSRPALQGRASSLGTEPDPALYLPARGALDGTRPDGP
Sbjct: 1 MAGASRHPTGTPRQLLVALACLLLSRPALQGRASSLGTEPDPALYLPARGALDGTRPDGP 60
Query: 61 SVLIANPGLRVPLGRSLWLDPLRDLVIGVQPGDRCEVTVLDALPRLKGALSPRRFPCTFG 120
SVLIANPGLRVPLGRSLWLDPLRDLVIGVQPGDRCEVTVLDALPRLKGALSPRRFPCTFG
Sbjct: 61 SVLIANPGLRVPLGRSLWLDPLRDLVIGVQPGDRCEVTVLDALPRLKGALSPRRFPCTFG 120
Query: 121 PRQVQYTHFGSHSPGRARVLLQLRYDAPTHTLVLPFTLAVDLVFSQLELVTRNRPLVVEK 180
PRQVQYTHFGSHSPGRARVLLQLRYDAPTHTLVLPFTLAVDLVFSQLELVTRNRPLVVEK
Sbjct: 121 PRQVQYTHFGSHSPGRARVLLQLRYDAPTHTLVLPFTLAVDLVFSQLELVTRNRPLVVEK 180
Query: 181 LRSWSRAIDRRVLDFASLKSGATATRRCRLTPLPHEDGPLPKYGRLVDAVGAPLPRGKGV 240
LRSWSRAIDRRVLDFASLKSGATATRRCRLTPLPHEDGPLPKYGRLVDAVGAPLPRGKGV
Sbjct: 181 LRSWSRAIDRRVLDFASLKSGATATRRCRLTPLPHEDGPLPKYGRLVDAVGAPLPRGKGV 240
Query: 241 DCEAFLRAGVRYQHTATSSPNRDYVPMMVELLGPEGQDAGSAGVLVREHFQLLVRIRGGA 300
DCEAFLRAGVRYQHTATSSPNRDYVPMMVELLGPEGQDAGSAGVLVREHFQLLVRIRGGA
Sbjct: 241 DCEAFLRAGVRYQHTATSSPNRDYVPMMVELLGPEGQDAGSAGVLVREHFQLLVRIRGGA 300
Query: 301 ENTPPRPSFMATMMMEVDPLVLTALTPDALAAEDVESDPGDLVFNILNAPTHPPGHPGQQ 360
ENTPPRPSFMATMMMEVDPLVLTALTPDALAAEDVESDPGDLVFNILNAPTHPPGHPGQQ
Sbjct: 301 ENTPPRPSFMATMMMEVDPLVLTALTPDALAAEDVESDPGDLVFNILNAPTHPPGHPGQQ 360
Query: 361 GYVVSTDDPLGLPVSFFTQQELRELKIAYQPPAENSHGERLFQLELEVVDGDGAASDPFA 420
GYVVSTDDPLGLPVSFFTQQELRELKIAYQPPAENSHGERLFQLELEVVDGDGAASDPFA
Sbjct: 361 GYVVSTDDPLGLPVSFFTQQELRELKIAYQPPAENSHGERLFQLELEVVDGDGAASDPFA 420
Query: 421 FMVTVKSMNTLVPVASHNRGLVLFEGQSRPLSSTHSIPISDKDNLEEVKMAAVRGLRHGQ 480
FMVTVKSMNTLVPVASHNRGLVLFEGQSRPLSSTHSIPISDKDNLEEVKMAAVRGLRHGQ
Sbjct: 421 FMVTVKSMNTLVPVASHNRGLVLFEGQSRPLSSTHSIPISDKDNLEEVKMAAVRGLRHGQ 480
Query: 481 LVVFGAPAGCKYFTPADLAAGRVVYQHDGSNTYSDNIIFRMEDGHHQVDFLFPLTILPVD 540
LVVFGAPAGCKYFTPADLAAGRVVYQHDGSNTYSDNIIFRMEDGHHQVDFLFPLTILPVD
Sbjct: 481 LVVFGAPAGCKYFTPADLAAGRVVYQHDGSNTYSDNIIFRMEDGHHQVDFLFPLTILPVD 540
Query: 541 DEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQPLKGNEEEPQWELA 600
DEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQPLKGNEEEPQWELA
Sbjct: 541 DEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQPLKGNEEEPQWELA 600
Query: 601 PGSSHSGHYLGDLLLQQAELPLSTEDEDWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHL 660
PGSSHSGHYLGDLLLQQAELPLSTEDEDWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHL
Sbjct: 601 PGSSHSGHYLGDLLLQQAELPLSTEDEDWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHL 660
Query: 661 GPHSPQSVMVQLAFHVQDDHDPPNLSKQHIFTIKVQPVDILSPQLYPGTTLEMTVQEYQL 720
GPHSPQSVMVQLAFHVQDDHDPPNLSKQHIFTIKVQPVDILSPQLYPGTTLEMTVQEYQL
Sbjct: 661 GPHSPQSVMVQLAFHVQDDHDPPNLSKQHIFTIKVQPVDILSPQLYPGTTLEMTVQEYQL 720
Query: 721 THFQKNFLRYIDQDSDDQNLWYTLLTLPTDTDGNHQVRAGEIVLTDSPDTLIMHFTQAQV 780
THFQKNFLRYIDQDSDDQNLWYTLLTLPTDTDGNHQVRAGEIVLTDSPDTLIMHFTQAQV
Sbjct: 721 THFQKNFLRYIDQDSDDQNLWYTLLTLPTDTDGNHQVRAGEIVLTDSPDTLIMHFTQAQV 780
Query: 781 NQHKVAYQPPQKLGIAPRVVQFTYQVEDAAGNSVPGTFTLFLQPVDNQPPEVTNRGFAIL 840
NQHKVAYQPPQKLGIAPRVVQFTYQVEDAAGNSVPGTFTLFLQPVDNQPPEVTNRGFAIL
Sbjct: 781 NQHKVAYQPPQKLGIAPRVVQFTYQVEDAAGNSVPGTFTLFLQPVDNQPPEVTNRGFAIL 840
Query: 841 EGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQYFKRCMVPGESFMQADVINGSV 900
EGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQYFKRCMVPGESFMQADVINGSV
Sbjct: 841 EGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQYFKRCMVPGESFMQADVINGSV 900
Query: 901 SYQHGRDQTTTSDTFHLEVSDGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVL 960
SYQHGRDQTTTSDTFHLEVSDGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVL
Sbjct: 901 SYQHGRDQTTTSDTFHLEVSDGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVL 960
Query: 961 ENKATEITMGVIHGKRKDVGDLMLSFIVKDSPKLGTILVNGLPTERFTQEDLINGRVAYA 1020
ENKATEITMGVIHGKRKDVGDLMLSFIVKDSPKLGTILVNGLPTERFTQEDLINGRVAYA
Sbjct: 961 ENKATEITMGVIHGKRKDVGDLMLSFIVKDSPKLGTILVNGLPTERFTQEDLINGRVAYA 1020
Query: 1021 HTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVLVGESFIV 1080
HTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVLVGESFIV
Sbjct: 1021 HTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVLVGESFIV 1080
Query: 1081 YEGEKNSLTLQHLHVEDVDTHQDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFS 1140
YEGEKNSLTLQHLHVEDVDTHQDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFS
Sbjct: 1081 YEGEKNSLTLQHLHVEDVDTHQDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFS 1140
Query: 1141 LRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHE 1200
LRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHE
Sbjct: 1141 LRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHE 1200
Query: 1201 FKVLEGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRIIQQLATGSQPIHSFTLKEI 1260
FKVLEGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRIIQQLATGSQPIHSFTLKEI
Sbjct: 1201 FKVLEGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRIIQQLATGSQPIHSFTLKEI 1260
Query: 1261 QEASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHLTVNNGLKVEKG 1320
QEASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHLTVNNGLKVEKG
Sbjct: 1261 QEASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHLTVNNGLKVEKG 1320
Query: 1321 HSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEI 1380
HSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEI
Sbjct: 1321 HSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEI 1380
Query: 1381 NRGLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEVISKRITLIEGA 1440
NRGLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEVISKRITLIEGA
Sbjct: 1381 NRGLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEVISKRITLIEGA 1440
Query: 1441 RVTLTNNLLTNSDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQLQLASNKISYVH 1500
RVTLTNNLLTNSDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQLQLASNKISYVH
Sbjct: 1441 RVTLTNNLLTNSDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQLQLASNKISYVH 1500
Query: 1501 TSNDEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKKPILTIHRLTLQKEDSQLITLLEL 1560
TSNDEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKKPILTIHRLTLQKEDSQLITLLEL
Sbjct: 1501 TSNDEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKKPILTIHRLTLQKEDSQLITLLEL 1560
Query: 1561 TVEDSDTPDDLILFTITQVPMHGKILYNGSRPVTTFTKQDLNKNLISYKHDGSETTEDSF 1620
TVEDSDTPDDLILFTITQVPMHGKILYNGSRPVTTFTKQDLNKNLISYKHDGSETTEDSF
Sbjct: 1561 TVEDSDTPDDLILFTITQVPMHGKILYNGSRPVTTFTKQDLNKNLISYKHDGSETTEDSF 1620
Query: 1621 SLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKRLHTGHMG 1680
SLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKRLHTGHMG
Sbjct: 1621 SLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKRLHTGHMG 1680
Query: 1681 FLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGNQSTRVFTQADIDEMKISYVL 1740
FLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGNQSTRVFTQADIDEMKISYVL
Sbjct: 1681 FLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGNQSTRVFTQADIDEMKISYVL 1740
Query: 1741 NEGSNASKDIFYFSVEDNGGNKLTNQPFHLNWAWICLEKEYYIVDEDSTFLEVTLTRRGY 1800
NEGSNASKDIFYFSVEDNGGNKLTNQPFHLNWAWICLEKEYYIVDEDSTFLEVTLTRRGY
Sbjct: 1741 NEGSNASKDIFYFSVEDNGGNKLTNQPFHLNWAWICLEKEYYIVDEDSTFLEVTLTRRGY 1800
Query: 1801 LGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWRVRIIPDNEYETSETFQII 1860
LGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWRVRIIPDNEYETSETFQII
Sbjct: 1801 LGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWRVRIIPDNEYETSETFQII 1860
Query: 1861 LSEPLMAVLEFPEMATVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELIV 1920
LSEPLMAVLEFPEMATVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELIV
Sbjct: 1861 LSEPLMAVLEFPEMATVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELIV 1920
Query: 1921 ICSTRQGSATGTISSTVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESF 1980
ICSTRQGSATGTISSTVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESF
Sbjct: 1921 ICSTRQGSATGTISSTVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESF 1980
Query: 1981 SVSLRLPVGGQLGARFPTTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDL 2040
SVSLRLPVGGQLGARFPTTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDL
Sbjct: 1981 SVSLRLPVGGQLGARFPTTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDL 2040
Query: 2041 SQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEK 2100
SQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEK
Sbjct: 2041 SQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEK 2100
Query: 2101 FELLLQMPMGAVLGEPNKTTIFIEDTITDCKQSACSSFD 2139
FELLLQMPMGAVLGEPNKTTIFIEDTITDCKQSACSSFD
Sbjct: 2101 FELLLQMPMGAVLGEPNKTTIFIEDTITDCKQSACSSFD 2139
>gi|169166334 PREDICTED: FRAS1 related extracellular matrix 3 [Homo
sapiens]
Length = 2139
Score = 4289 bits (11125), Expect = 0.0
Identities = 2138/2139 (99%), Positives = 2138/2139 (99%)
Query: 1 MAGASRHPTGTPRQLLVALACLLLSRPALQGRASSLGTEPDPALYLPARGALDGTRPDGP 60
MAGASRHPTGTPRQLLVALACLLLSRPALQGRASSLGTEPDPALYLPARGALDGTRPDGP
Sbjct: 1 MAGASRHPTGTPRQLLVALACLLLSRPALQGRASSLGTEPDPALYLPARGALDGTRPDGP 60
Query: 61 SVLIANPGLRVPLGRSLWLDPLRDLVIGVQPGDRCEVTVLDALPRLKGALSPRRFPCTFG 120
SVLIANPGLRVPLGRSLWLDPLRDLVIGVQPGDRCEVTVLDALPRLKGALSPRRFPCTFG
Sbjct: 61 SVLIANPGLRVPLGRSLWLDPLRDLVIGVQPGDRCEVTVLDALPRLKGALSPRRFPCTFG 120
Query: 121 PRQVQYTHFGSHSPGRARVLLQLRYDAPTHTLVLPFTLAVDLVFSQLELVTRNRPLVVEK 180
PRQVQYTHFGSHSPGRARVLLQLRYDAPTHTLVLPFTLAVDLVFSQLELVTRNRPLVVEK
Sbjct: 121 PRQVQYTHFGSHSPGRARVLLQLRYDAPTHTLVLPFTLAVDLVFSQLELVTRNRPLVVEK 180
Query: 181 LRSWSRAIDRRVLDFASLKSGATATRRCRLTPLPHEDGPLPKYGRLVDAVGAPLPRGKGV 240
LRSWSRAIDRRVLDFASLKSGATATRRCRLTPLPHEDGPLPKYGRLVDAVGAPLPRGKGV
Sbjct: 181 LRSWSRAIDRRVLDFASLKSGATATRRCRLTPLPHEDGPLPKYGRLVDAVGAPLPRGKGV 240
Query: 241 DCEAFLRAGVRYQHTATSSPNRDYVPMMVELLGPEGQDAGSAGVLVREHFQLLVRIRGGA 300
DCEAFLRAGVRYQHTATSSPNRDYVPMMVELLGPEGQDAGSAGVLVREHFQLLVRIRGGA
Sbjct: 241 DCEAFLRAGVRYQHTATSSPNRDYVPMMVELLGPEGQDAGSAGVLVREHFQLLVRIRGGA 300
Query: 301 ENTPPRPSFMATMMMEVDPLVLTALTPDALAAEDVESDPGDLVFNILNAPTHPPGHPGQQ 360
ENTPPRPSFMATMMMEVDPLVLTALTPDALAAEDVESDPGDLVFNILNAPTHPPGHPGQQ
Sbjct: 301 ENTPPRPSFMATMMMEVDPLVLTALTPDALAAEDVESDPGDLVFNILNAPTHPPGHPGQQ 360
Query: 361 GYVVSTDDPLGLPVSFFTQQELRELKIAYQPPAENSHGERLFQLELEVVDGDGAASDPFA 420
GYVVSTDDPLGLPVSFFTQQELRELKIAYQPPAENSHGERLFQLELEVVDGDGAASDPFA
Sbjct: 361 GYVVSTDDPLGLPVSFFTQQELRELKIAYQPPAENSHGERLFQLELEVVDGDGAASDPFA 420
Query: 421 FMVTVKSMNTLVPVASHNRGLVLFEGQSRPLSSTHSIPISDKDNLEEVKMAAVRGLRHGQ 480
FMVTVKSMNTLVPVASHNRGLVLFEGQSRPLSSTHSIPISDKDNLEEVKMAAVRGLRHGQ
Sbjct: 421 FMVTVKSMNTLVPVASHNRGLVLFEGQSRPLSSTHSIPISDKDNLEEVKMAAVRGLRHGQ 480
Query: 481 LVVFGAPAGCKYFTPADLAAGRVVYQHDGSNTYSDNIIFRMEDGHHQVDFLFPLTILPVD 540
LVVFGAPAGCKYFTPADLAAGRVVYQHDGSNTYSDNIIFRMEDGHHQVDFLFPLTILPVD
Sbjct: 481 LVVFGAPAGCKYFTPADLAAGRVVYQHDGSNTYSDNIIFRMEDGHHQVDFLFPLTILPVD 540
Query: 541 DEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQPLKGNEEEPQWELA 600
DEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQPLKGNEEEPQWELA
Sbjct: 541 DEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQPLKGNEEEPQWELA 600
Query: 601 PGSSHSGHYLGDLLLQQAELPLSTEDEDWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHL 660
PGSSHSGHYLGDLLLQQAELPLSTEDEDWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHL
Sbjct: 601 PGSSHSGHYLGDLLLQQAELPLSTEDEDWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHL 660
Query: 661 GPHSPQSVMVQLAFHVQDDHDPPNLSKQHIFTIKVQPVDILSPQLYPGTTLEMTVQEYQL 720
GPHSPQSVMVQLAFHVQDDHDPPNLSKQHIFTIKVQPVDILSPQLYPGTTLEMTVQEYQL
Sbjct: 661 GPHSPQSVMVQLAFHVQDDHDPPNLSKQHIFTIKVQPVDILSPQLYPGTTLEMTVQEYQL 720
Query: 721 THFQKNFLRYIDQDSDDQNLWYTLLTLPTDTDGNHQVRAGEIVLTDSPDTLIMHFTQAQV 780
THFQKNFLRYIDQDSDDQNLWYTLLTLPTDTDGNHQVRAGEIVLTDSPDTLIMHFTQAQV
Sbjct: 721 THFQKNFLRYIDQDSDDQNLWYTLLTLPTDTDGNHQVRAGEIVLTDSPDTLIMHFTQAQV 780
Query: 781 NQHKVAYQPPQKLGIAPRVVQFTYQVEDAAGNSVPGTFTLFLQPVDNQPPEVTNRGFAIL 840
NQHKVAYQPPQKLGIAPRVVQFTYQVEDAAGNSVPGTFTLFLQPVDNQPPEVTNRGFAIL
Sbjct: 781 NQHKVAYQPPQKLGIAPRVVQFTYQVEDAAGNSVPGTFTLFLQPVDNQPPEVTNRGFAIL 840
Query: 841 EGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQYFKRCMVPGESFMQADVINGSV 900
EGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQYFKRCMVPGESFMQADVINGSV
Sbjct: 841 EGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQYFKRCMVPGESFMQADVINGSV 900
Query: 901 SYQHGRDQTTTSDTFHLEVSDGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVL 960
SYQHGRDQTTTSDTFHLEVSDGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVL
Sbjct: 901 SYQHGRDQTTTSDTFHLEVSDGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVL 960
Query: 961 ENKATEITMGVIHGKRKDVGDLMLSFIVKDSPKLGTILVNGLPTERFTQEDLINGRVAYA 1020
ENKATEITMGVIHGKRKDVGDLMLSFIVKDSPKLGTILVNGLPTERFTQEDLINGRVAYA
Sbjct: 961 ENKATEITMGVIHGKRKDVGDLMLSFIVKDSPKLGTILVNGLPTERFTQEDLINGRVAYA 1020
Query: 1021 HTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVLVGESFIV 1080
HTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQVQVTVLPVDNVGPKV VGESFIV
Sbjct: 1021 HTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVFVGESFIV 1080
Query: 1081 YEGEKNSLTLQHLHVEDVDTHQDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFS 1140
YEGEKNSLTLQHLHVEDVDTHQDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFS
Sbjct: 1081 YEGEKNSLTLQHLHVEDVDTHQDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFS 1140
Query: 1141 LRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHE 1200
LRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHE
Sbjct: 1141 LRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHE 1200
Query: 1201 FKVLEGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRIIQQLATGSQPIHSFTLKEI 1260
FKVLEGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRIIQQLATGSQPIHSFTLKEI
Sbjct: 1201 FKVLEGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRIIQQLATGSQPIHSFTLKEI 1260
Query: 1261 QEASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHLTVNNGLKVEKG 1320
QEASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHLTVNNGLKVEKG
Sbjct: 1261 QEASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHLTVNNGLKVEKG 1320
Query: 1321 HSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEI 1380
HSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEI
Sbjct: 1321 HSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEI 1380
Query: 1381 NRGLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEVISKRITLIEGA 1440
NRGLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEVISKRITLIEGA
Sbjct: 1381 NRGLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEVISKRITLIEGA 1440
Query: 1441 RVTLTNNLLTNSDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQLQLASNKISYVH 1500
RVTLTNNLLTNSDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQLQLASNKISYVH
Sbjct: 1441 RVTLTNNLLTNSDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQLQLASNKISYVH 1500
Query: 1501 TSNDEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKKPILTIHRLTLQKEDSQLITLLEL 1560
TSNDEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKKPILTIHRLTLQKEDSQLITLLEL
Sbjct: 1501 TSNDEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKKPILTIHRLTLQKEDSQLITLLEL 1560
Query: 1561 TVEDSDTPDDLILFTITQVPMHGKILYNGSRPVTTFTKQDLNKNLISYKHDGSETTEDSF 1620
TVEDSDTPDDLILFTITQVPMHGKILYNGSRPVTTFTKQDLNKNLISYKHDGSETTEDSF
Sbjct: 1561 TVEDSDTPDDLILFTITQVPMHGKILYNGSRPVTTFTKQDLNKNLISYKHDGSETTEDSF 1620
Query: 1621 SLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKRLHTGHMG 1680
SLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKRLHTGHMG
Sbjct: 1621 SLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKRLHTGHMG 1680
Query: 1681 FLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGNQSTRVFTQADIDEMKISYVL 1740
FLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGNQSTRVFTQADIDEMKISYVL
Sbjct: 1681 FLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGNQSTRVFTQADIDEMKISYVL 1740
Query: 1741 NEGSNASKDIFYFSVEDNGGNKLTNQPFHLNWAWICLEKEYYIVDEDSTFLEVTLTRRGY 1800
NEGSNASKDIFYFSVEDNGGNKLTNQPFHLNWAWICLEKEYYIVDEDSTFLEVTLTRRGY
Sbjct: 1741 NEGSNASKDIFYFSVEDNGGNKLTNQPFHLNWAWICLEKEYYIVDEDSTFLEVTLTRRGY 1800
Query: 1801 LGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWRVRIIPDNEYETSETFQII 1860
LGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWRVRIIPDNEYETSETFQII
Sbjct: 1801 LGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWRVRIIPDNEYETSETFQII 1860
Query: 1861 LSEPLMAVLEFPEMATVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELIV 1920
LSEPLMAVLEFPEMATVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELIV
Sbjct: 1861 LSEPLMAVLEFPEMATVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELIV 1920
Query: 1921 ICSTRQGSATGTISSTVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESF 1980
ICSTRQGSATGTISSTVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESF
Sbjct: 1921 ICSTRQGSATGTISSTVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESF 1980
Query: 1981 SVSLRLPVGGQLGARFPTTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDL 2040
SVSLRLPVGGQLGARFPTTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDL
Sbjct: 1981 SVSLRLPVGGQLGARFPTTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDL 2040
Query: 2041 SQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEK 2100
SQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEK
Sbjct: 2041 SQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEK 2100
Query: 2101 FELLLQMPMGAVLGEPNKTTIFIEDTITDCKQSACSSFD 2139
FELLLQMPMGAVLGEPNKTTIFIEDTITDCKQSACSSFD
Sbjct: 2101 FELLLQMPMGAVLGEPNKTTIFIEDTITDCKQSACSSFD 2139
>gi|79749430 FRAS1-related extracellular matrix protein 2 precursor
[Homo sapiens]
Length = 3169
Score = 2383 bits (6175), Expect = 0.0
Identities = 1242/2153 (57%), Positives = 1566/2153 (72%), Gaps = 81/2153 (3%)
Query: 8 PTGTPRQLLVALACLLL-----SRPALQGRASSLGTEPDPALYLPARGALDGTRPDGPSV 62
P PR LL+ L L L ++PA GRA L P G P ++
Sbjct: 24 PPPPPRLLLLLLLLLSLVSRVPAQPAAFGRA----------LLSPGLAGAAGV-PAEEAI 72
Query: 63 LIANPGLRVPLGRSLWLDPLRDLVIGVQPGDRCEVTVLD--ALPRLKGALSPRRFPCTFG 120
++AN GLRVP GR +WLDPL DLV+ VQPGDRC V+VLD AL + G LSP+RFPC FG
Sbjct: 73 VLANRGLRVPFGREVWLDPLHDLVLQVQPGDRCAVSVLDNDALAQRPGRLSPKRFPCDFG 132
Query: 121 PRQVQYTHFGSHSPGRARVLLQLRYDAPTHTLVLPFTLAVDLVFSQLELVTRNRPLVVEK 180
P +V+Y+H G+ SP R RV LQLRYDAP +VLP L V++VF+QLE+VTRN PLVVE+
Sbjct: 133 PGEVRYSHLGARSPSRDRVRLQLRYDAPGGAVVLPLVLEVEVVFTQLEVVTRNLPLVVEE 192
Query: 181 LRSWSRAIDRRVLDFASLKSGATATRRCRLTPLPHEDGPLPKYGRLVDAVGAPLPRGKG- 239
L S A+D R L+FA T CR+ L G LP+YG L+ P +G
Sbjct: 193 LLGTSNALDARSLEFAFQPE----TEECRVGILSGL-GALPRYGELLHYPQVPGGAREGG 247
Query: 240 ------VDCEAFLRAGVRYQHTATS-SPNRDYVPMMVELLGPEGQDAGSAGVLVREHFQL 292
+DC+AF GVRY+HTA S SPNRD++PM+VEL G GS L REHFQ+
Sbjct: 248 APETLLMDCKAFQELGVRYRHTAASRSPNRDWIPMVVELRS-RGAPVGSPA-LKREHFQV 305
Query: 293 LVRIRGGAENTPPRPSFMATMMMEVDPLVLTALTPDALAAEDVESDPGDLVFNILNAPTH 352
LVRIRGGAENT P+PSF+A MMMEVD VLTALTPD LAAED ES L+FN+ +
Sbjct: 306 LVRIRGGAENTAPKPSFVAMMMMEVDQFVLTALTPDMLAAEDAESPSDLLIFNLTS---- 361
Query: 353 PPGHPGQQGYVVSTDDPLGLPVSFFTQQELRELKIAYQPPAENSHGERLFQLELEVVDGD 412
P PGQ GY+VSTDD LP+S FTQ++LR LKIAYQPP+E+S ERLF+LELEVVD +
Sbjct: 362 -PFQPGQ-GYLVSTDDR-SLPLSSFTQRDLRLLKIAYQPPSEDSDQERLFELELEVVDLE 418
Query: 413 GAASDPFAFMVTVKSMNTLVPVASHNRGLVLFEGQSRPL-----SSTHSIPISDKDNLEE 467
GAASDPFAFMV VK MNT+ PV + N GL+L+EGQSRPL S ++ ISD+D+LE
Sbjct: 419 GAASDPFAFMVVVKPMNTMAPVVTRNTGLILYEGQSRPLTGPAGSGPQNLVISDEDDLEA 478
Query: 468 VKMAAVRGLRHGQLVVFGAPAGC---KYFTPADLAAGRVVYQHDGSN-TYSDNIIFRMED 523
V++ V GLRHG LV+ GA +G K FT A+LAAG+VVYQHD + + SDN++ RM D
Sbjct: 479 VRLEVVAGLRHGHLVILGASSGSSAPKSFTVAELAAGQVVYQHDDRDGSLSDNLVLRMVD 538
Query: 524 G--HHQVDFLFPLTILPVDDEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHF 581
G HQV FLFP+T++PVDD+PP++N NTGL+L EG+ V I P LSATD+DS+DS + F
Sbjct: 539 GGGRHQVQFLFPITLVPVDDQPPVLNANTGLTLAEGETVPILPLSLSATDMDSDDSLLLF 598
Query: 582 VLENQPLKGNEEEPQWELAPGSSHSGHYLGDLLLQQAELPLSTEDEDWHYMEKEG-LYEK 640
VLE+ L G LLL+Q P ++ KEG YE+
Sbjct: 599 VLESPFLT--------------------TGHLLLRQTHPPHEKQELLRGLWRKEGAFYER 638
Query: 641 VVTEWLQRDIMEGRLFYRHLGPHSPQSVMVQLAFHVQDDHDPPNLSKQHIFTIKVQPVDI 700
VTEW Q+DI EGRLFYRH GPHSP V Q F VQD+HDPPN S F I++ PVD
Sbjct: 639 TVTEWQQQDITEGRLFYRHSGPHSPGPVTDQFTFRVQDNHDPPNQSGLQRFVIRIHPVDR 698
Query: 701 LSPQLYPGTTLEMTVQEYQLTHFQKNFLRYIDQDSDDQNLWYTLLTLPTDTDGNH-QVRA 759
L P+L G L M VQE QLT +K +LRY D D+DD+ L YT+ PTDTD NH
Sbjct: 699 LPPELGSGCPLRMVVQESQLTPLRKKWLRYTDLDTDDRELRYTVTQSPTDTDENHLPAPL 758
Query: 760 GEIVLTDSPDTLIMHFTQAQVNQHKVAYQPP-QKLGIAPRVVQFTYQVEDAAGNSVPGTF 818
G +VLTD+P ++ HFTQAQ+N HK+AY+PP Q+LG+A RV QF +QVED AGN PGTF
Sbjct: 759 GTLVLTDNPSVVVTHFTQAQINHHKIAYRPPGQELGVATRVAQFQFQVEDRAGNVAPGTF 818
Query: 819 TLFLQPVDNQPPEVTNRGFAILEGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQ 878
TL+L PVDNQPPE+ N GF I E G LS ELHV D DTD+ I F L + P+HGH++
Sbjct: 819 TLYLHPVDNQPPEILNTGFTIQEKGHHILSETELHVNDVDTDVAHISFTLTQAPKHGHMR 878
Query: 879 YFKRCMVPGESFMQADVINGSVSYQHGRDQTTTSDTFHLEVSDGVHHIPITIPISVHPNV 938
+ + G F D+ G VSY H D++ T D+ LEVSD H +PIT+ ++V P V
Sbjct: 879 VSGQILHVGGLFHLEDIKQGRVSYAHNGDKSLT-DSCSLEVSDRHHVVPITLRVNVRP-V 936
Query: 939 ANRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDVGDLMLSFIVKDSPKLGTIL 998
+ P +S + L+ +DVLEN ATEIT VI G ++ DLML+F+++D P G IL
Sbjct: 937 DDEVPILS-HPTGTLESYLDVLENGATEITANVIKGTNEETDDLMLTFLLEDPPLYGEIL 995
Query: 999 VNGLPTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQV 1058
VNG+P E+FTQ D++ G V Y HT+GE+G + D+F+L LS S +W +G + I+ V +
Sbjct: 996 VNGIPAEQFTQRDILEGSVVYTHTSGEIGLLPKADSFNLSLSDMSQEWRIGGNTIQGVTI 1055
Query: 1059 QVTVLPVDNVGPKVLVGESFIVYEGEKNSLTLQHLHVEDVDTHQDELLCTVTSQPASGYL 1118
VT+LPVD+ P++ VGE IV EG+K+ +T H+ EDVD+ D++LCT+ QP SGY+
Sbjct: 1056 WVTILPVDSQAPEIFVGEQLIVMEGDKSVITSVHISAEDVDSLNDDILCTIVIQPTSGYV 1115
Query: 1119 EKIASAPGSKMSQSGSPISAFSLRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSP 1178
E I+ APGS+ S++G ISAF+L+D++ HINYVQS+HKGVEP ED+F F CSDGINFS
Sbjct: 1116 ENISPAPGSEKSRAGIAISAFNLKDLRQGHINYVQSVHKGVEPVEDRFVFRCSDGINFSE 1175
Query: 1179 NVFFPIIILPTNDEQPKLFAHEFKVLEGMSLVIDTQLLNGADADLPPNELHFQLTALPRH 1238
FFPI+I+PTNDEQP++F EF V+EGMSLVIDT +LN ADAD+P ++L F +T P H
Sbjct: 1176 RQFFPIVIIPTNDEQPEMFMREFMVMEGMSLVIDTPILNAADADVPLDDLTFTITQFPTH 1235
Query: 1239 GRIIQQLATGSQPIHSFTLKEIQEASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIV 1298
G I+ QL G+ + SFTL +I E+S+I+YEHDDSET+EDSF + L+DGKH+ + V I+
Sbjct: 1236 GHIMNQLINGTVLVESFTLDQIIESSSIIYEHDDSETQEDSFVIKLTDGKHSVEKTVLII 1295
Query: 1299 VTLVDDETPHLTVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRL 1358
V VDDETP +T+NNGL++E G ++II N+IL ATDLDS+DKSL +++ GP GLLQR
Sbjct: 1296 VIPVDDETPRMTINNGLEIEIGDTKIINNKILMATDLDSEDKSLVYIIRYGPGHGLLQR- 1354
Query: 1359 RKPRGEVRNNLTLGMNFTQDEINRGLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVT 1418
RKP G N +TLGMNFTQDE++R LI Y+H GQEGI D+IKFDVTDG+N L D YFYV+
Sbjct: 1355 RKPTGAFEN-ITLGMNFTQDEVDRNLIQYVHLGQEGIRDLIKFDVTDGINPLIDRYFYVS 1413
Query: 1419 IGNLDSVFPEVISKRITLIEGARVTLTNNLLTNSDINSSDEHH-FSITRAPSLGHLESSD 1477
IG++D VFP+VISK ++L EG +VTLT +LL+ SD+NS DE+ F+ITRAP GHLE +D
Sbjct: 1414 IGSIDIVFPDVISKGVSLKEGGKVTLTTDLLSTSDLNSPDENLVFTITRAPMRGHLECTD 1473
Query: 1478 YAGEPIASFTQLQLASNKISYVHTSNDEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKK 1537
G I SFTQLQLA NKI Y+HT++DE KMDSFEFQV PVFRTFRI I+DVDNKK
Sbjct: 1474 QPGVSITSFTQLQLAGNKIYYIHTADDEVKMDSFEFQVTDGRNPVFRTFRISISDVDNKK 1533
Query: 1538 PILTIHRLTLQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHGKILYNGSRPVTTFT 1597
P++TIH+L + + +++LIT ELTVED DTPD L+ FTITQVP+HG +L+N +RPV FT
Sbjct: 1534 PVVTIHKLVVSESENKLITPFELTVEDRDTPDKLLKFTITQVPIHGHLLFNNTRPVMVFT 1593
Query: 1598 KQDLNKNLISYKHDGSETTEDSFSLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDN 1657
KQDLN+NLISYKHDG+E++EDSFS TVTDGTHTDFYV PDT T +PQVM++Q+ ++DN
Sbjct: 1594 KQDLNENLISYKHDGTESSEDSFSFTVTDGTHTDFYVFPDTVFETRRPQVMKIQVLAVDN 1653
Query: 1658 RLPQITTNRGAPALKRLHTGHMGFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTG 1717
+PQI N+GA L+ L TGH+GF+ITSK LK ED+DS H L++ VT P+HG+++
Sbjct: 1654 SVPQIAVNKGASTLRTLATGHLGFMITSKILKVEDRDSLHISLRFIVTEAPQHGYLLNLD 1713
Query: 1718 LGNQSTRVFTQADIDEMKISYVLNEGSNASKDIFYFSVEDNGGNKLTNQPFHLNWAWICL 1777
GN S FTQADID+MKI YVL EG+NA+ D+FYF+VED GGNKLT Q F LNWAWI
Sbjct: 1714 KGNHSITQFTQADIDDMKICYVLREGANATSDMFYFAVEDGGGNKLTYQNFRLNWAWISF 1773
Query: 1778 EKEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQT 1837
EKEYY+V+EDS FL+V L RRGYLGETSFISIGT+D TA+KDKDFK K KQ+QFNPGQT
Sbjct: 1774 EKEYYLVNEDSKFLDVVLKRRGYLGETSFISIGTRDRTAEKDKDFKGKAQKQVQFNPGQT 1833
Query: 1838 TATWRVRIIPDNEYETSETFQIILSEPLMAVLEFPEMATVEIVDPGDESTVYIPEAEYKI 1897
ATWRVRI+ D E+E SETFQ++LSEP++A LEFP +ATVEIVDPGDE TV+IP+++Y +
Sbjct: 1834 RATWRVRILSDGEHEQSETFQVVLSEPVLAALEFPTVATVEIVDPGDEPTVFIPQSKYSV 1893
Query: 1898 EEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVL-FSDYISRPEDHTSILHFD 1956
EED+GEL IP+RRSGD SQEL+V+C T+QG+ATGT+ ++VL +SDYISRPEDHTS++ FD
Sbjct: 1894 EEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLSYSDYISRPEDHTSVVRFD 1953
Query: 1957 KNETQKTCQVLIIDDSLYEEEESFSVSLRLPVGGQLGARFPTTKVTILADRYDEPVLHFG 2016
K+E +K C+++IIDDSLYEEEE+F V L +P+GG++G+ FP +VTI+ D+ DEP+ +FG
Sbjct: 1954 KDEREKLCRIVIIDDSLYEEEETFHVLLSMPMGGRIGSEFPGAQVTIVPDKDDEPIFYFG 2013
Query: 2017 DAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPG 2076
D EY V+ESA YVEV VWR GTDLS+ SS+ VRSRK++ SA+AGTDYVGISRNLDFAPG
Sbjct: 2014 DVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVGISRNLDFAPG 2073
Query: 2077 VRMQTFQVTILDDLGQPTLEGPEKFELLLQMPMGAVLGEPNKTTIFIEDTITD 2129
V MQ +V ILDDLGQP LEG EKFEL+L+MPM A LGEP+K T+ I D+++D
Sbjct: 2074 VNMQPVRVVILDDLGQPALEGIEKFELVLRMPMNAALGEPSKATVSINDSVSD 2126
Score = 110 bits (274), Expect = 2e-23
Identities = 96/323 (29%), Positives = 147/323 (45%), Gaps = 26/323 (8%)
Query: 1782 YIVDEDSTFLEVTLTRRGY-LGETSFISIG---TKDETAKKDKDFKWKTNKQIQFNPGQT 1837
Y VDE + ++EV + R G L ++S +++ T +A D+ ++ + F PG
Sbjct: 2017 YSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGTDYVG-ISRNLDFAPGVN 2075
Query: 1838 TATWRVRIIPD---NEYETSETFQIILSEPLMAVLEFPEMATVEIVDP-GDESTVYIPEA 1893
RV I+ D E E F+++L P+ A L P ATV I D D + E
Sbjct: 2076 MQPVRVVILDDLGQPALEGIEKFELVLRMPMNAALGEPSKATVSINDSVSDLPKMQFKER 2135
Query: 1894 EYKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVLFSDYISRPEDHTSIL 1953
Y E G+++ + R+GD V C TRQGSA + D+ RP TSI+
Sbjct: 2136 IYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQ-------VMMDFEERPNTDTSII 2188
Query: 1954 HFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLPVGGQ-LGARFPTTKVTI--LADRYDE 2010
F ET+K C + ++DD LYEE E + L P GA T+ + D D+
Sbjct: 2189 TFLPGETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADK 2248
Query: 2011 PVLHFGDAEYHVNESARYVEVCVWR----RGTDLSQPSSIAVRSRKSEQESAEAGTDYVG 2066
V+ FG+ ++ V E E V R R D S+ S + V ++ SA +G DY
Sbjct: 2249 TVIKFGETKFSVTEPKEPGESVVIRIPVIRQGDTSKVSIVRVHTKDG---SATSGEDYHP 2305
Query: 2067 ISRNLDFAPGVRMQTFQVTILDD 2089
+S ++F G ++ + D
Sbjct: 2306 VSEEIEFKEGETQHVVEIEVTFD 2328
Score = 87.8 bits (216), Expect = 1e-16
Identities = 97/377 (25%), Positives = 160/377 (42%), Gaps = 42/377 (11%)
Query: 1775 ICLEKEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKD--------KDFKWKT 1826
+ + + Y V+ED L + + R G + + + T+ TA D+ +
Sbjct: 1884 VFIPQSKYSVEEDVGELFIPIRRSGDVSQELMVVCYTQQGTATGTVPTSVLSYSDYISRP 1943
Query: 1827 NKQ---IQFNPGQTTATWRVRIIPDNEYETSETFQIILSEPLMAVL--EFPEMATVEIVD 1881
++F+ + R+ II D+ YE ETF ++LS P+ + EFP + D
Sbjct: 1944 EDHTSVVRFDKDEREKLCRIVIIDDSLYEEEETFHVLLSMPMGGRIGSEFPGAQVTIVPD 2003
Query: 1882 PGDESTVYIPEAEYKIEEDIGELLIPVRRSG-DASQELIVICSTRQGSATGTISSTVLFS 1940
DE Y + EY ++E G + + V R+G D S+ V +R+ + T
Sbjct: 2004 KDDEPIFYFGDVEYSVDESAGYVEVQVWRTGTDLSKSSSVTVRSRKTDPPSADAGT---- 2059
Query: 1941 DYISRPEDHTSILHFDKNETQKTCQVLIIDD---SLYEEEESFSVSLRLPVGGQLGARFP 1997
DY+ + L F + +V+I+DD E E F + LR+P+ LG
Sbjct: 2060 DYVGISRN----LDFAPGVNMQPVRVVILDDLGQPALEGIEKFELVLRMPMNAALGEPSK 2115
Query: 1998 TTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSRKSEQES 2057
T V+I D P + F + Y +ES + + R G D+ SS+ +R Q S
Sbjct: 2116 AT-VSINDSVSDLPKMQFKERIYTGSESDGQIVTMIHRTG-DVQYRSSVRCYTR---QGS 2170
Query: 2058 AEAGTDYVGISRN----LDFAPGVRMQTFQVTILDDLGQPTLEGPEKFELLL-----QMP 2108
A+ D+ + F PG + + ++DD+ E E+ L+L P
Sbjct: 2171 AQVMMDFEERPNTDTSIITFLPGETEKPCILELMDDV---LYEEVEELRLVLGTPQSNSP 2227
Query: 2109 MGAVLGEPNKTTIFIED 2125
GA +GE N+T I I D
Sbjct: 2228 FGAAVGEQNETLIRIRD 2244
Score = 60.5 bits (145), Expect = 2e-08
Identities = 56/221 (25%), Positives = 97/221 (43%), Gaps = 24/221 (10%)
Query: 1778 EKEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQ---IQFNP 1834
++ Y E + + R G + S + T+ +A+ DF+ + N I F P
Sbjct: 2133 KERIYTGSESDGQIVTMIHRTGDVQYRSSVRCYTRQGSAQVMMDFEERPNTDTSIITFLP 2192
Query: 1835 GQTTATWRVRIIPDNEYETSETFQIIL-----SEPLMAVLEFPEMATVEIVDPGDESTVY 1889
G+T + ++ D YE E +++L + P A + + I D D++ +
Sbjct: 2193 GETEKPCILELMDDVLYEEVEELRLVLGTPQSNSPFGAAVGEQNETLIRIRDDADKTVIK 2252
Query: 1890 IPEAEYKIEE--DIGE---LLIPVRRSGDASQELIVICSTRQGSATGTISSTVLFSDYIS 1944
E ++ + E + GE + IPV R GD S+ IV T+ GSAT DY
Sbjct: 2253 FGETKFSVTEPKEPGESVVIRIPVIRQGDTSKVSIVRVHTKDGSATSG-------EDYHP 2305
Query: 1945 RPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLR 1985
E+ + F + ETQ ++ + D + E E+F+V L+
Sbjct: 2306 VSEE----IEFKEGETQHVVEIEVTFDGVREMREAFTVHLK 2342
>gi|122056683 FRAS1 related extracellular matrix 1 [Homo sapiens]
Length = 2179
Score = 852 bits (2200), Expect = 0.0
Identities = 608/1897 (32%), Positives = 913/1897 (48%), Gaps = 145/1897 (7%)
Query: 60 PSVLIANPGLRVPLGRSLWL--DPLRDLVIGVQPGDRCEVTVLDALPRLKGALSPRRFPC 117
P+ + N G+RV G S +L D L+ + + + EV + + + + G L+P+ F C
Sbjct: 23 PTFISINRGVRVMKGHSAFLSGDDLKFAIPKEKDACKVEVVMNEPITQRVGKLTPQVFDC 82
Query: 118 TFGPRQVQYTHFGSHSPGRARVLLQLRYDAPTHTLVLPFTLAVDLVFSQLELV-TRNRPL 176
F P +V+Y H G V L+L T + F L V L+ ++ N L
Sbjct: 83 HFLPNEVKYVHNGCPILDEDTVKLRLYRFTERDTFIETFILWVYLLEPDCNIIHMSNNVL 142
Query: 177 VVEKLRSWSRAIDRRVLDF-----ASLKSGATA-TRRCRLT---------PLPHE---DG 218
V + S+AID+ +L F ASL+ + T R RL P P E D
Sbjct: 143 EVPEFNGLSQAIDKNLLRFDYDRMASLECTVSLDTARTRLPAHGQMVLGEPRPEEPRGDQ 202
Query: 219 PLPKYGRLVDAVGAPLPRGK-----------GVDCEAFLRAGVRYQHTATSSPNRDYVPM 267
P + P G V CE FL G+RYQH SPN DY+ +
Sbjct: 203 PHSFFPESQLRAKLKCPGGSCTPGLKKIGSLKVSCEEFLLMGLRYQHLDPPSPNIDYISI 262
Query: 268 MVELLGPEGQDAGSAGVLVREHFQLLVRIRGGAENTPPRPSFMATMMMEVDPLVLTALTP 327
++L D S V E L V IR G N P+ +FMA ++EVD +LT+LT
Sbjct: 263 QLDLT-----DTRSKIVYKSESAWLPVYIRAGIPNQIPKAAFMAVFILEVDQFILTSLTT 317
Query: 328 DALAAEDVESDPGDLVFNILNAPTHPPGHPGQQGYVVSTDDPLGLPVSFFTQQELRELKI 387
L E+ E+ LVFNI AP QGYV D P+S FT ++L +++I
Sbjct: 318 SVLDCEEDETPKPLLVFNITKAPL--------QGYVTHLLDHTR-PISSFTWKDLSDMQI 368
Query: 388 AYQPPAENSHGERLF-QLELEVVDGDGAASDPFAFMVTVKSMNTLVPVASHNRGLVLFEG 446
AYQPP +SH ER ++ELEV D S P +++++ +T P S N GL L EG
Sbjct: 369 AYQPP-NSSHSERRHDEVELEVYDFFFERSAPMTVHISIRTADTNAPRVSWNTGLSLLEG 427
Query: 447 QSRPLSSTHSIPISDKDNLEEVKMAAVRGLRHGQLVVFGAPAGCKYFTPADLAAGRVVYQ 506
QSR ++ + D D++ V++ V GL+HG L + G FT ADL AG V Y
Sbjct: 428 QSRAIT-WEQFQVVDNDDIGAVRLVTVGGLQHGWLTLRGGKGFL--FTVADLQAGVVRYH 484
Query: 507 HDGSNTYSDNIIFRMEDGHHQVDFLFPLTILPVDDEPPMVNTNTGLSLTEGQVVQISPFV 566
HD S++ D ++FR+ DGHH + FP+ +LP DD PP + TN + L EGQ + I +
Sbjct: 485 HDDSDSTKDFVVFRIFDGHHSIRHKFPINVLPKDDSPPFLITNVVIELEEGQTILIQGSM 544
Query: 567 LSATDIDSEDSTIHFVLENQPLKGNEEEPQWELAPGSSHSGHYLGDLLLQQAELPLSTED 626
L A+D+D+ D I F + P G + PG
Sbjct: 545 LRASDVDASDDYIFFNITKPPQAGEIMKK-----PGP----------------------- 576
Query: 627 EDWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHLGPHSPQSVMVQLAFHVQDDHDPPNLS 686
GL V +LQRD+ G ++YRH G + F + D H+PPNLS
Sbjct: 577 ---------GLIGYPVHGFLQRDLFNGIIYYRHFGGEIFED---SFQFVLWDSHEPPNLS 624
Query: 687 KQHIFTIKVQPVDILSPQLYPGTTLEMTVQEYQLTHFQKNFLRYIDQDSDDQNLWYTLLT 746
+ TI + PVD P+ PG + + V+E ++ + K L +ID +S D+ L YT+ T
Sbjct: 625 VPQVATIHITPVDDQLPKEAPGVSRHLVVKETEVAYITKKQLHFIDSESYDRELVYTITT 684
Query: 747 LPTDTDGNHQVRAGEIVLTDSPDTLIMH--------FTQAQVNQHKVAYQPP-QKLGIAP 797
P + + + AG++ + DS ++ + FTQ VN KVAY PP Q +G
Sbjct: 685 PPFFSFSHRHLDAGKLFMVDSIPKVVKNPTALELRSFTQHAVNYMKVAYMPPMQDIGPHC 744
Query: 798 RVVQFTYQVEDAAGNSVPGT-FTLFLQPVDNQPPEVTNRGFAILEGGSFNLSSNELHVTD 856
R VQFT+ V + G ++ G F + + PVDNQ PE + EGG +S+ + ++D
Sbjct: 745 RDVQFTFSVSNQHGGTLHGICFNITILPVDNQVPEAFTNPLKVTEGGQSIISTEHILISD 804
Query: 857 PDTDIDQIVFILVRGPQHGHLQYFKRCMVPGESFMQADVINGSVSYQHGRDQTTTSDTFH 916
DT +D I L P HG ++ + G +F D+ V YQH + D
Sbjct: 805 ADTKLDNIDLSLRELPLHGRVELNGFPLNSGGTFSWGDLHTLKVRYQHDGTEVLQDDLL- 863
Query: 917 LEVSDGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKR 976
LEV+DG + + + V P N P + + L+ V ++ E IT I
Sbjct: 864 LEVTDGTNSAEFVLHVEVFP--VNDEPPVL--KADLMPV-MNCSEGGEVVITSEYIFATD 918
Query: 977 KDVGDLMLSFIVKDSPKLGTILVNGLPTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFS 1036
D +L L F++ P+ G + G+ ++F+Q D+I+ V Y HT GE+G D +
Sbjct: 919 VDSDNLKLMFVIAREPQHGVVRRAGVTVDQFSQRDVISEAVTYKHTGGEIGLMPCFDTIT 978
Query: 1037 LILSK-DSYQWVVG------------NSIIEKVQVQVTVLPVDNVGPKVLVGESFIVYEG 1083
L++S ++ +V G ++ + +TV PVDN P + +G F+V EG
Sbjct: 979 LVVSDGEAGPFVNGCCYNGPNPSVPLHASFPVYDLNITVYPVDNQPPSIAIGPVFVVDEG 1038
Query: 1084 EKNSLTLQHLHVEDVDTHQDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFSLRD 1143
+LT+ HL D DT D+L + S P GYLE I + G + S G I +F +D
Sbjct: 1039 CSTALTVNHLSATDPDTAADDLEFVLVSPPQFGYLENILPSVGFEKSNIGISIDSFQWKD 1098
Query: 1144 IQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEFKV 1203
+ HINYVQS H +EP DQFT Y +DG + S + F III PTNDE P V
Sbjct: 1099 MNAFHINYVQSRHLRIEPTADQFTVYVTDGKHHSLEIPFSIIINPTNDEAPDFVVQNITV 1158
Query: 1204 LEGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRII-----------QQLATGSQ-- 1250
EG +D+ +++ D D+P + L F +T PRHG +I +Q A Q
Sbjct: 1159 CEGQMKELDSSIISAVDLDIPQDALLFSITQKPRHGLLIDRGFSKDFSENKQPANPHQKH 1218
Query: 1251 -PIHSFTLKEIQEASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHL 1309
P+HSF+++ ++ + Y HDDSE+ D F + LSDGKH + + + V V+DE P L
Sbjct: 1219 APVHSFSMELLKTGMRLTYMHDDSESLADDFTIQLSDGKHKILKTISVEVIPVNDEKPML 1278
Query: 1310 TVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNL 1369
+ + + G + II++ IL A D DS + + +V PQ G LQ L+ R V L
Sbjct: 1279 SKKAEIAMNMGETRIISSAILSAIDEDSPREKIYYVFERLPQNGQLQ-LKIGRDWV--PL 1335
Query: 1370 TLGMNFTQDEINRGLICYIHTG--QEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFP 1427
+ GM TQ+E++ L+ Y HTG D F + DG N +TI +++
Sbjct: 1336 SPGMKCTQEEVDLNLLRYTHTGAMDSQNQDSFTFYLWDGNNRSPALDCQITIKDMEKGDI 1395
Query: 1428 EVISKRITLIEGARVTL-TNNLLTNSDINSSDEHHFSITRAPSLGHLESSDYAGEPIASF 1486
+++K + + +G R L T LL + +E + IT P G +E Y G PI +F
Sbjct: 1396 VILTKPLVVSKGDRGFLTTTTLLAVDGTDKPEELLYVITSPPRYGQIEYVHYPGVPITNF 1455
Query: 1487 TQLQLASNKISYVHTSNDEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKKPILTIHR-L 1545
+Q+ + + YVH S D F F + L F I + VD P++T ++ L
Sbjct: 1456 SQMDVVGQTVCYVHKSKVTVSSDRFRFIISNGLRTEHGVFEITLETVDRALPVVTRNKGL 1515
Query: 1546 TLQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHGKILYNGSRPVT-TFTKQDLNKN 1604
L + L++ L + D DTP + + F + Q+P HG++ G+ + FT+QD++
Sbjct: 1516 RLAQGAVGLLSPDLLQLTDPDTPAENLTFLLVQLPQHGQLYLWGTGLLQHNFTQQDVDSK 1575
Query: 1605 LISYKHDGSETTEDSFSLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITT 1664
++Y+H G ++ D F+ TDGT+ F V +P + +Q+ LD P+IT
Sbjct: 1576 NVAYRHSGGDSQTDCFTFMATDGTNQGFIV---NGRVWEEPVLFTIQVDQLDKTAPRITL 1632
Query: 1665 NRGAPALKRLHTGHMGFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGNQSTR 1724
+ L G G ITS+ LKA D D+ + +K+ +GP+HG + T G
Sbjct: 1633 LHSPSQVGLLKNGCYGIYITSRVLKASDPDTEDDQIIFKILQGPKHGHLENTTTGEFIHE 1692
Query: 1725 VFTQADIDEMKISYVLNEGSNASKDIFYFSVEDNGGNKLTNQPFHLNWAWICLEKEYYIV 1784
F+Q D++ I Y++N + D F + D GN T Q L W+ I + Y V
Sbjct: 1693 KFSQKDLNSKTILYIINPSLEVNSDTVEFQIMDPTGNSATPQILELKWSHIEWSQTEYEV 1752
Query: 1785 DEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWRVR 1844
E+ L + + RRGY +++F+ I +A KDF +K IQF+PG +T W +
Sbjct: 1753 CENVGLLPLEIIRRGYSMDSAFVGIKVNQVSAAVGKDFTVIPSKLIQFDPGMSTKMWNIA 1812
Query: 1845 IIPDNEYETSETFQIILSEPLMAVLEFPEMATVEIVD 1881
I D E E F++IL+ P+ AVL A V+I+D
Sbjct: 1813 ITYDGLEEDDEVFEVILNSPVNAVLGTKTKAAVKILD 1849
Score = 215 bits (548), Expect = 3e-55
Identities = 352/1512 (23%), Positives = 596/1512 (39%), Gaps = 237/1512 (15%)
Query: 649 DIMEGRLFYRHLGPHSPQSVMVQLAFHVQDDHDPPNLSKQHIFTIKVQPVDILSPQLYPG 708
D+ G + Y H S + +V F + D H S +H F I V P D P L
Sbjct: 475 DLQAGVVRYHHDDSDSTKDFVV---FRIFDGHH----SIRHKFPINVLPKDDSPPFLITN 527
Query: 709 TTLEMTVQEYQLTHFQKNFLRYIDQDSDDQNLWYTLLTLPTDTDGNHQVRAGEIVLTDSP 768
+E+ +E Q Q + LR D D+ D +++ + P +AGEI+ P
Sbjct: 528 VVIEL--EEGQTILIQGSMLRASDVDASDDYIFFNITKPP---------QAGEIMKKPGP 576
Query: 769 DTL---IMHFTQAQVNQHKVAYQPPQKLGIAPRVVQFTYQV-----EDAAGNSVPGTFTL 820
+ + F Q + + Y+ + + ++Q + SVP T+
Sbjct: 577 GLIGYPVHGFLQRDLFNGIIYYRH-----FGGEIFEDSFQFVLWDSHEPPNLSVPQVATI 631
Query: 821 FLQPVDNQPPEVT---NRGFAILEGGSFNLSSNELHVTDPDTDIDQIVFILVRGP----Q 873
+ PVD+Q P+ +R + E ++ +LH D ++ ++V+ + P
Sbjct: 632 HITPVDDQLPKEAPGVSRHLVVKETEVAYITKKQLHFIDSESYDRELVYTITTPPFFSFS 691
Query: 874 HGHLQYFKRCMVPG-------------ESFMQADVINGSVSYQ--------HGRDQTTTS 912
H HL K MV SF Q V V+Y H RD
Sbjct: 692 HRHLDAGKLFMVDSIPKVVKNPTALELRSFTQHAVNYMKVAYMPPMQDIGPHCRD---VQ 748
Query: 913 DTFHLEVSDGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVLENKATEITMGVI 972
TF + G I I++ P V N+ P + + ++ +TE +
Sbjct: 749 FTFSVSNQHGGTLHGICFNITILP-VDNQVPEAFTNPLKVTEGGQSII---STEHILISD 804
Query: 973 HGKRKDVGDLMLSFIVKDSPKLGTILVNGLPTER---FTQEDLINGRVAYAHTAGEVGFQ 1029
+ D DL L ++ P G + +NG P F+ DL +V Y H EV
Sbjct: 805 ADTKLDNIDLSL----RELPLHGRVELNGFPLNSGGTFSWGDLHTLKVRYQHDGTEV--- 857
Query: 1030 KQHDAFSLILSKDSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVLVGESFIVY---EGEKN 1086
L D V + + + V V PV N P VL + V EG +
Sbjct: 858 ---------LQDDLLLEVTDGTNSAEFVLHVEVFPV-NDEPPVLKADLMPVMNCSEGGEV 907
Query: 1087 SLTLQHLHVEDVDTHQDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFSLRDIQV 1146
+T +++ DVD+ +L+ + +P G + + +G + FS RD+
Sbjct: 908 VITSEYIFATDVDSDNLKLMFVIAREPQHGVVRR-----------AGVTVDQFSQRDVIS 956
Query: 1147 RHINYVQSIHK-GVEPQEDQFTFYCSDG-----INF----SPNVFFP-----------II 1185
+ Y + + G+ P D T SDG +N PN P I
Sbjct: 957 EAVTYKHTGGEIGLMPCFDTITLVVSDGEAGPFVNGCCYNGPNPSVPLHASFPVYDLNIT 1016
Query: 1186 ILPTNDEQPKL-FAHEFKVLEGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRIIQQ 1244
+ P +++ P + F V EG S + L+ D D ++L F L + P+ G +
Sbjct: 1017 VYPVDNQPPSIAIGPVFVVDEGCSTALTVNHLSATDPDTAADDLEFVLVSPPQFGYLENI 1076
Query: 1245 L-ATGSQP------IHSFTLKEIQ--EASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKV 1295
L + G + I SF K++ + + H E D F V+++DGKH + ++
Sbjct: 1077 LPSVGFEKSNIGISIDSFQWKDMNAFHINYVQSRHLRIEPTADQFTVYVTDGKHHS-LEI 1135
Query: 1296 P--IVVTLVDDETPHLTVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHSGPQQG 1353
P I++ +DE P V N + V +G + + + I+ A DLD +L F + P+ G
Sbjct: 1136 PFSIIINPTNDEAPDFVVQN-ITVCEGQMKELDSSIISAVDLDIPQDALLFSITQKPRHG 1194
Query: 1354 LL---------QRLRKPRGEVRNNLTLGMNFTQDEINRGL-ICYIHTGQEGIVDIIKFDV 1403
LL ++P + + + +F+ + + G+ + Y+H E + D +
Sbjct: 1195 LLIDRGFSKDFSENKQPANPHQKHAPVH-SFSMELLKTGMRLTYMHDDSESLADDFTIQL 1253
Query: 1404 TDGVNTLTDHYFYVTIGNLDSVFPEVISKR--ITLIEGARVTLTNNLLTNSDINSSDEH- 1460
+DG + + I D ++SK+ I + G +++ +L+ D +S E
Sbjct: 1254 SDGKHKILKTISVEVIPVNDE--KPMLSKKAEIAMNMGETRIISSAILSAIDEDSPREKI 1311
Query: 1461 HFSITRAPSLGHLE---SSDYAG-EPIASFTQLQLASNKISYVHT-SNDEKKMDSFEFQV 1515
++ R P G L+ D+ P TQ ++ N + Y HT + D + DSF F +
Sbjct: 1312 YYVFERLPQNGQLQLKIGRDWVPLSPGMKCTQEEVDLNLLRYTHTGAMDSQNQDSFTFYL 1371
Query: 1516 I-GELYPVFRTFRIFITDVDNKKPILTIHRLTLQKEDSQLITLLEL-TVEDSDTPDDLIL 1573
G +I I D++ ++ L + K D +T L V+ +D P++L L
Sbjct: 1372 WDGNNRSPALDCQITIKDMEKGDIVILTKPLVVSKGDRGFLTTTTLLAVDGTDKPEEL-L 1430
Query: 1574 FTITQVPMHGKILY--NGSRPVTTFTKQDLNKNLISYKHDGSET-TEDSFSLTVTDGTHT 1630
+ IT P +G+I Y P+T F++ D+ + Y H T + D F +++G T
Sbjct: 1431 YVITSPPRYGQIEYVHYPGVPITNFSQMDVVGQTVCYVHKSKVTVSSDRFRFIISNGLRT 1490
Query: 1631 DFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKRLHTGHMGFLITSKSLKA 1690
+ V + + ++D LP +T N+G RL G +G L++ L+
Sbjct: 1491 EH-------------GVFEITLETVDRALPVVTRNKGL----RLAQGAVG-LLSPDLLQL 1532
Query: 1691 EDQDSPHRLLKYKVTRGPEHGFIIKTGLGNQSTRVFTQADIDEMKISYVLNEGSNASKDI 1750
D D+P L + + + P+HG + G G FTQ D+D ++Y + G ++ D
Sbjct: 1533 TDPDTPAENLTFLLVQLPQHGQLYLWGTGLLQHN-FTQQDVDSKNVAY-RHSGGDSQTDC 1590
Query: 1751 FYFSVEDNGGNKLTNQPFHLNWAWICLEKEYYIVDEDS--------TFL----EVTLTRR 1798
F F D TNQ F +N + E + + D T L +V L +
Sbjct: 1591 FTFMATDG-----TNQGFIVNGR-VWEEPVLFTIQVDQLDKTAPRITLLHSPSQVGLLKN 1644
Query: 1799 GYLGE--TSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWRVRIIPDNEYETSET 1856
G G TS + + +T FK + TT + + +
Sbjct: 1645 GCYGIYITSRVLKASDPDTEDDQIIFKILQGPKHGHLENTTTGEFIHEKFSQKDLNSKTI 1704
Query: 1857 FQIILSEPLMAVLEFPEMATVEIVDP-GDESTVYIPE----------AEYKIEEDIGELL 1905
II P + V + +I+DP G+ +T I E EY++ E++G L
Sbjct: 1705 LYII--NPSLEVNS--DTVEFQIMDPTGNSATPQILELKWSHIEWSQTEYEVCENVGLLP 1760
Query: 1906 IPVRRSGDASQELIVICSTRQGSATGTISSTVLFSDYISRPEDHTSILHFDKNETQKTCQ 1965
+ + R G + V Q SA TV+ S ++ FD + K
Sbjct: 1761 LEIIRRGYSMDSAFVGIKVNQVSAAVGKDFTVIPS----------KLIQFDPGMSTKMWN 1810
Query: 1966 VLIIDDSLYEEEESFSVSLRLPVGGQLGARFPTTKVTILADRYDEPVLHFGDAEYHVNES 2025
+ I D L E++E F V L PV LG + TK + +L + H + S
Sbjct: 1811 IAITYDGLEEDDEVFEVILNSPVNAVLGTK---TKAAV-------KILDSKGGQCHPSYS 1860
Query: 2026 ARYVEVCVWRRG 2037
+ + W +G
Sbjct: 1861 SNQSKHSTWEKG 1872
Score = 208 bits (529), Expect = 5e-53
Identities = 315/1437 (21%), Positives = 567/1437 (39%), Gaps = 212/1437 (14%)
Query: 812 NSVPGTFTLFLQPVDNQPPE-VTNRGFAILEGGSFNLSSNELHVTDPDTDIDQIVFILVR 870
+S+ F + + P D+ PP +TN + EG + + + L +D D D I F + +
Sbjct: 504 HSIRHKFPINVLPKDDSPPFLITNVVIELEEGQTILIQGSMLRASDVDASDDYIFFNITK 563
Query: 871 GPQHGHLQYFKRCMV---PGESFMQADVINGSVSYQHGRDQTTTSDTFHLEVSDGVHHIP 927
PQ G + + P F+Q D+ NG + Y+H + D+F + D
Sbjct: 564 PPQAGEIMKKPGPGLIGYPVHGFLQRDLFNGIIYYRHFGGEIF-EDSFQFVLWDSHEPPN 622
Query: 928 ITIP----ISVHPNVANRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDVGDLM 983
+++P I + P V ++ P+ + S L V E + IT +H + D
Sbjct: 623 LSVPQVATIHITP-VDDQLPKEAPGVSRHLVVK----ETEVAYITKKQLHFIDSESYDRE 677
Query: 984 LSFIVKDSPKLG----------TILVNGLPT----------ERFTQEDLINGRVAYAHTA 1023
L + + P +V+ +P FTQ + +VAY
Sbjct: 678 LVYTITTPPFFSFSHRHLDAGKLFMVDSIPKVVKNPTALELRSFTQHAVNYMKVAYMPPM 737
Query: 1024 GEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVLVGESFIVYEG 1083
++G + F+ +S + + +T+LPVDN P+ V EG
Sbjct: 738 QDIGPHCRDVQFTFSVSNQH------GGTLHGICFNITILPVDNQVPEAFTNP-LKVTEG 790
Query: 1084 EKNSLTLQHLHVEDVDTHQDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFSLRD 1143
++ ++ +H+ + D DT D + ++ P G +E G ++ G+ FS D
Sbjct: 791 GQSIISTEHILISDADTKLDNIDLSLRELPLHGRVE----LNGFPLNSGGT----FSWGD 842
Query: 1144 IQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEFKV 1203
+ + Y H G E +D +DG N S + + P NDE P L A V
Sbjct: 843 LHTLKVRYQ---HDGTEVLQDDLLLEVTDGTN-SAEFVLHVEVFPVNDEPPVLKADLMPV 898
Query: 1204 L---EGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRIIQQLATGSQPIHSFTLKEI 1260
+ EG +VI ++ + D D +L F + P+HG + + T Q F+ +++
Sbjct: 899 MNCSEGGEVVITSEYIFATDVDSDNLKLMFVIAREPQHGVVRRAGVTVDQ----FSQRDV 954
Query: 1261 QEASTIVYEHDDSETKE----DSFEVWLSDGKH----------------TTHRKVP---- 1296
+ + Y+H E D+ + +SDG+ H P
Sbjct: 955 I-SEAVTYKHTGGEIGLMPCFDTITLVVSDGEAGPFVNGCCYNGPNPSVPLHASFPVYDL 1013
Query: 1297 -IVVTLVDDETPHLTVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLL 1355
I V VD++ P + + V++G S +T L ATD D+ L FVL S PQ G L
Sbjct: 1014 NITVYPVDNQPPSIAIGPVFVVDEGCSTALTVNHLSATDPDTAADDLEFVLVSPPQFGYL 1073
Query: 1356 QRLRKPRGEVRNNLTLGMN-FTQDEINRGLICYI---HTGQEGIVDIIKFDVTDGVNTLT 1411
+ + G ++N+ + ++ F ++N I Y+ H E D VTDG +
Sbjct: 1074 ENILPSVGFEKSNIGISIDSFQWKDMNAFHINYVQSRHLRIEPTADQFTVYVTDGKHHSL 1133
Query: 1412 DHYFYVTIGNLDSVFPEVISKRITLIEGARVTLTNNLLTNSDIN-SSDEHHFSITRAPSL 1470
+ F + I + P+ + + IT+ EG L +++++ D++ D FSIT+ P
Sbjct: 1134 EIPFSIIINPTNDEAPDFVVQNITVCEGQMKELDSSIISAVDLDIPQDALLFSITQKPRH 1193
Query: 1471 GHLESSDYAGE---------------PIASFT-QLQLASNKISYVHTSNDEKKMDSFEFQ 1514
G L ++ + P+ SF+ +L +++Y+H + E D F Q
Sbjct: 1194 GLLIDRGFSKDFSENKQPANPHQKHAPVHSFSMELLKTGMRLTYMH-DDSESLADDFTIQ 1252
Query: 1515 VIGELYPVFRTFRIFITDVDNKKPILTIH-RLTLQKEDSQLITLLELTVEDSDTPDDLIL 1573
+ + + +T + + V+++KP+L+ + + ++++I+ L+ D D+P + I
Sbjct: 1253 LSDGKHKILKTISVEVIPVNDEKPMLSKKAEIAMNMGETRIISSAILSAIDEDSPREKIY 1312
Query: 1574 FTITQVPMHGKILYNGSR------PVTTFTKQDLNKNLISYKHDGS--ETTEDSFSLTVT 1625
+ ++P +G++ R P T+++++ NL+ Y H G+ +DSF+ +
Sbjct: 1313 YVFERLPQNGQLQLKIGRDWVPLSPGMKCTQEEVDLNLLRYTHTGAMDSQNQDSFTFYLW 1372
Query: 1626 DGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKRLHTGHMGFLITS 1685
DG + + + QI D I + + G GFL T+
Sbjct: 1373 DGNN--------------RSPALDCQITIKDMEKGDIVILTKPLVVSK---GDRGFLTTT 1415
Query: 1686 KSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGNQSTRVFTQADIDEMKISY------- 1738
L + D P LL Y +T P +G I F+Q D+ + Y
Sbjct: 1416 TLLAVDGTDKPEELL-YVITSPPRYGQIEYVHYPGVPITNFSQMDVVGQTVCYVHKSKVT 1474
Query: 1739 --------VLNEGSNASKDIFYFSVED----------NGGNKLTNQPFHLNWAWICLEKE 1780
+++ G +F ++E N G +L L + +
Sbjct: 1475 VSSDRFRFIISNGLRTEHGVFEITLETVDRALPVVTRNKGLRLAQGAVGLLSPDLLQLTD 1534
Query: 1781 YYIVDEDSTFLEVTLTRRG--YLGETSFISIG-TKDETAKKDKDFKWK--TNKQIQFNPG 1835
E+ TFL V L + G YL T + T+ + K+ ++ ++ F
Sbjct: 1535 PDTPAENLTFLLVQLPQHGQLYLWGTGLLQHNFTQQDVDSKNVAYRHSGGDSQTDCFTFM 1594
Query: 1836 QTTATWRVRIIPDNEYETSETFQIILSE-----PLMAVLEFPEMATVEIVDPGDESTVYI 1890
T T + I+ +E F I + + P + +L P V ++ G +YI
Sbjct: 1595 ATDGTNQGFIVNGRVWEEPVLFTIQVDQLDKTAPRITLLHSPSQ--VGLLKNGCYG-IYI 1651
Query: 1891 PEAEYKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVLFSDYISRPEDHT 1950
K + D + I+ QG G + +T ++I
Sbjct: 1652 TSRVLKASDP------------DTEDDQIIF-KILQGPKHGHLENTTT-GEFIHEK---- 1693
Query: 1951 SILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLPVGGQLGARFPTTKVTILADRYDE 2010
F + + + II+ SL ++ + P G + IL ++
Sbjct: 1694 ----FSQKDLNSKTILYIINPSLEVNSDTVEFQIMDPTGNSATPQ-------ILELKWSH 1742
Query: 2011 PVLHFGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGI-SR 2069
+ + EY V E+ + + + RRG + A K Q SA G D+ I S+
Sbjct: 1743 --IEWSQTEYEVCENVGLLPLEIIRRGYSMDS----AFVGIKVNQVSAAVGKDFTVIPSK 1796
Query: 2070 NLDFAPGVRMQTFQVTILDDLGQPTLEGPEKFELLLQMPMGAVLGEPNKTTIFIEDT 2126
+ F PG+ + + + I D + E E FE++L P+ AVLG K + I D+
Sbjct: 1797 LIQFDPGMSTKMWNIAITYDGLE---EDDEVFEVILNSPVNAVLGTKTKAAVKILDS 1850
>gi|108773804 Fraser syndrome 1 [Homo sapiens]
Length = 4011
Score = 676 bits (1743), Expect = 0.0
Identities = 557/1860 (29%), Positives = 872/1860 (46%), Gaps = 128/1860 (6%)
Query: 330 LAAEDVESDPGDLVFNILNAPTHPPGHPGQQGYVVSTDDPLGLPVSFFTQQELRELKIAY 389
L +D E DL+F++++ PT+ + G V D F+ +++ E K+ +
Sbjct: 1125 LNVQDQEGRVEDLLFHVVSTPTNGQLVLSRNGKEVQLDK-----AGRFSWKDVNEKKVRF 1179
Query: 390 QPPAENSHGERLFQLELEVVDGDGAASDPFAFMVTVKSMNTLVPVASHNRGLVLFEGQSR 449
E LF L++ D S+P ++ +++ +T P N L + G+ R
Sbjct: 1180 VHSKEKLRKGYLF---LKISDQQ-FFSEPQ--LINIQAFSTQAPYVLRNEVLHISRGE-R 1232
Query: 450 PLSSTHSIPISDKDNLEEVKMAAVRGLRHGQLV-VFGAPAGCKY-FTPADLAAGRVVYQH 507
+T + I D DN ++V + + HGQL+ +PA Y F +L+ G + Y H
Sbjct: 1233 ATITTQMLDIRDDDNPQDVVIEIIDPPLHGQLLQTLQSPATPIYQFQLDELSRGLLHYAH 1292
Query: 508 DGSNTYSDNIIFRMEDGHHQVDFLFPLTILPVDDEPPMVNTNTGLSLTEGQVVQISPFVL 567
DGS++ SD + + DGH + LF + +P +D + N+ + + EG ++QI+ +L
Sbjct: 1293 DGSDSTSDVAVLQANDGHSFHNILFQVKTVPQNDRGLQLVANSMVWVPEGGMLQITNRIL 1352
Query: 568 SATDIDSEDSTIHFVLENQPLKGNEEEPQWELAPGSSHSGHYLGDLLLQQAELPLSTEDE 627
A + I + K ++ PQ+ G+++L S DE
Sbjct: 1353 QAEAPGASAEEIIY-------KITQDYPQF-------------GEVVLLVNMPADSPADE 1392
Query: 628 DWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHLGPHSPQSVMVQLAFHVQDDHDPPNLSK 687
H +G + + Q+DI EG ++YRH G + F V + +
Sbjct: 1393 GQHL--PDGRTATPTSTFTQQDINEGIVWYRHSGAPAQSD---SFRFEVSSASNAQTRLE 1447
Query: 688 QHIFTIKVQPVDILSPQLYPGTTLEMTVQEYQLTHFQKNFLRYIDQDSDDQNLWYTLLTL 747
H+F I + P +P++ +L MT +E LT Q + L +I+ + + Y + TL
Sbjct: 1448 SHMFNIAILPQTPEAPKVSLEASLHMTAREDGLTVIQPHSLSFINSEKPSGKIVYNI-TL 1506
Query: 748 PTDTDGNHQVRAGEIVLTDSPDTLIMHFTQAQVNQHKVAYQPPQ-----------KLGIA 796
P + G I D P + I +FTQ +NQ KV Y+PP
Sbjct: 1507 PLHPN------QGIIEHRDHPHSPIRYFTQEDINQGKVMYRPPPAAPHLQELMAFSFAGL 1560
Query: 797 PRVVQFTYQVEDAAGNSVPGTFTLFLQPVDNQPP--EVTNRGFAILEGGSFNLSSNELHV 854
P V+F + V D S T+ L P D Q P +VT A+ GGS ++ ++ V
Sbjct: 1561 PESVKFHFTVSDGEHTSPEMVLTIHLLPSDQQLPVFQVTAPRLAVSPGGSTSVGL-QVVV 1619
Query: 855 TDPDTDIDQIVFILVRGPQHG----HLQYFKRCMVPGESFMQADVINGSVSYQHGRDQTT 910
D +T ++ F L R PQHG H F+R M G++F DV ++ Y H +T
Sbjct: 1620 RDAETAPKELFFELRRPPQHGVLLKHTAEFRRPMATGDTFTYEDVEKNALQYIHD-GSST 1678
Query: 911 TSDTFHLEVSDGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVLENKATEITMG 970
D+ + V+DG+ + + + V + +R PR++ SS +SI V IT
Sbjct: 1679 REDSMEISVTDGLTVTMLEVRVEVSLS-EDRGPRLAAGSS----LSITVASKSTAIITRS 1733
Query: 971 VIHGKRKDVGDLMLSFIVKDSPKLGTIL-VNGLPTER------FTQEDLINGRVAYAHTA 1023
+ D + + P GT+L ++G E FT ED+ N ++ Y+
Sbjct: 1734 HLAYVDDSSPDPEIWIQLNYLPSYGTLLRISGSEVEELSEVSNFTMEDINNKKIRYSAVF 1793
Query: 1024 GEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQVQV---TVLPVDNVGPKVLVGESFIV 1080
G L DS+ + V + + Q+ + P +N P + + V
Sbjct: 1794 ETDGH----------LVTDSFYFSVSDMDHNHLDNQIFTIMITPAENPPPVIAFADLITV 1843
Query: 1081 YEGEKNSLTLQHLHVEDVDTH-QDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAF 1139
EG + L+ H D D + Q + + +++ P G +E + + ++F
Sbjct: 1844 DEGGRAPLSFHHFFATDDDDNLQRDAIIKLSALPKYGCIENTGTGDRFGPETASDLEASF 1903
Query: 1140 SLRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAH 1199
++D+ +I Y QS+H+ +EP D F+FY SDG + S I I NDE P++
Sbjct: 1904 PIQDVLENYIYYFQSVHESIEPTHDIFSFYVSDGTSRSEIHSINITIERKNDEPPRMTLQ 1963
Query: 1200 EFKVLEGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRIIQQLATGSQPIHS----- 1254
+V +VI L+ D D P NEL F LT P HG ++ + T S+P+ +
Sbjct: 1964 PLRVQLSSGVVISNSSLSLQDLDTPDNELIFVLTKKPDHGHVLWR-QTASEPLENGRVLV 2022
Query: 1255 ----FTLKEIQEASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHLT 1310
FT ++I A + Y D F+ L+DG H ++ I L +TPHL
Sbjct: 2023 QGSTFTYQDIL-AGLVGYVPSVPGMVVDEFQFSLTDGLHVDTGRMKIYTELPASDTPHLA 2081
Query: 1311 VNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNLT 1370
+N GL++ G IT + LK TD+DSDD + +++ P G LQ ++ E +
Sbjct: 2082 INQGLQLSAGSVARITEQHLKVTDIDSDDHQVMYIMKEDPGAGRLQMMKHGNLEQISIKG 2141
Query: 1371 LGMNFTQDEINRGLICYIH-TGQEGIVDIIKFDVTDGV-NTLTDHYFYVTIGNLDSVFPE 1428
+FTQ +I++G Y H TG+ G KFDV DG N L D F ++I L+ P
Sbjct: 2142 PIRSFTQADISQGQPEYSHGTGEPGGSFAFKFDVVDGEGNRLIDKSFSISI--LEDKSPP 2199
Query: 1429 VIS--KRITLIEGARVTLTNNLLTNSDINSSD-EHHFSITRAPSLGHLESSDYAGEPIAS 1485
VI+ K + L E + +T L+ +D +S E + ITR P LGHLE + G I+S
Sbjct: 2200 VITTNKGLVLDENSVKKITTLQLSATDQDSGPTELIYRITRQPQLGHLEHAASPGIQISS 2259
Query: 1486 FTQLQLASNKISYVHTSNDEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKKPILTIHRL 1545
FTQ L S + YVH+S EK D+F F + + V +TF I + VD+ P++ +
Sbjct: 2260 FTQADLTSRNVQYVHSSEAEKHSDAFSFTLSDGVSEVTQTFHITLHPVDDSLPVVQNLGM 2319
Query: 1546 TLQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHGKI--LYNGS--RPVTTFTKQDL 1601
+Q+ + IT EL D+DT + + FTI Q P HG I NG +TFT +D+
Sbjct: 2320 RVQEGMRKTITEFELKAVDADTEAESVTFTIVQPPRHGTIERTSNGQHFHLTSTFTMKDI 2379
Query: 1602 NKNLISYKHDGSETTEDSFSLTVTDGTHTDFYVLPD--TALATHKPQVMRVQIRSLDNRL 1659
+N +SY HDGS + +D F+ TV+DGT+ F+++ + + T PQ RV I +D+
Sbjct: 2380 YQNRVSYSHDGSNSLKDRFTFTVSDGTN-PFFIIEEGGKEIMTAAPQPFRVDILPVDDGT 2438
Query: 1660 PQITTNRGAPALKRLHTGHMGFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLG 1719
P+I TN G L+ + G LIT K L D D+ L Y++T GP+HGF+
Sbjct: 2439 PRIVTNLGLQWLEYM-DGKATNLITKKELLTMDPDTEDAQLVYEITTGPKHGFVENKLQP 2497
Query: 1720 NQSTRVFTQADIDEMKISYVLN-EGSNASKDIFYFSVEDNGGNKLTNQPFHLNWAWICLE 1778
++ FTQ D++ I YVL+ E D F F V+D+ N +++ FH+ W+ I +
Sbjct: 2498 GRAAATFTQEDVNLGLIRYVLHKEKIREMMDSFQFLVKDSKPNVVSDNVFHIQWSLISFK 2557
Query: 1779 KEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNK--------QI 1830
Y V E + + VT+ R G L + + + T+ TA + + Q+
Sbjct: 2558 YTSYNVSEKAGSVSVTVQRTGNLNQYAIVLCRTEQGTASSSSRVSSQPGQQDYVEYAGQV 2617
Query: 1831 QFNPGQTTATWRVRIIPDNEYETSETFQIILSEPLMAVLEFPEMATVEIVDPGDESTVYI 1890
QF+ + T + + I D+ +E E+F + LS P A+L A V I D DE T+
Sbjct: 2618 QFDEREDTKSCTIVINDDDVFENVESFTVELSMPAYALLGEFTQAKVIINDTEDEPTLEF 2677
Query: 1891 PEAEYKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATG-TISSTVLFSDYISRPEDH 1949
+ Y + E G L P+ R GDAS + IC T SA G ++ + SD+ SR
Sbjct: 2678 DKKIYWVNESAGFLFAPIERKGDASSIVSAICYTVPKSAMGSSLYALESGSDFKSRGMSA 2737
Query: 1950 TSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLPVGGQLGARFPTTKVTILADRYD 2009
S + F T TC V++IDDS YEEEE F ++L R T KV +++ D
Sbjct: 2738 ASRVIFGPGVTMSTCDVMLIDDSEYEEEEEFEIALADASDNARIGRVATAKV-LISGPND 2796
Query: 2010 EPVLHFGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISR 2069
+ G+ + V+E A V++ V R GTDLS +S+ +R S+ SA G DYV SR
Sbjct: 2797 ASTVSLGNTAFTVSEDAGTVKIPVIRHGTDLSTFASVWCATRPSDPASATPGVDYVPSSR 2856
Query: 2070 NLDFAPGVRMQTFQVTILDDLGQPTLEGPEKFELLLQMPMGAVLGEPNKTTIFIEDTITD 2129
++F PGV Q +TILDD P +EG E F + L GA L +P + I I DT D
Sbjct: 2857 KVEFGPGVIEQYCTLTILDDTQYPVIEGLETFVVFLSSAQGAELTKPFQAVIAINDTFQD 2916
Score = 118 bits (296), Expect = 5e-26
Identities = 113/369 (30%), Positives = 172/369 (46%), Gaps = 33/369 (8%)
Query: 1775 ICLEKEYYIVDEDSTFLEVTLTRRGY-LGETSFISIGTKDE---TAKKDKDFKWKTNKQI 1830
+ L + V ED+ +++ + R G L + + T+ +A D+ +++++
Sbjct: 2800 VSLGNTAFTVSEDAGTVKIPVIRHGTDLSTFASVWCATRPSDPASATPGVDYV-PSSRKV 2858
Query: 1831 QFNPGQTTATWRVRIIPDNEY---ETSETFQIILSEPLMAVLEFPEMATVEIVDP-GDES 1886
+F PG + I+ D +Y E ETF + LS A L P A + I D D
Sbjct: 2859 EFGPGVIEQYCTLTILDDTQYPVIEGLETFVVFLSSAQGAELTKPFQAVIAINDTFQDVP 2918
Query: 1887 TVYIPEAEYKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVLFSDYISRP 1946
++ + ++E G L +P+ RSGD S E V C T+ SA + D+ R
Sbjct: 2919 SMQFAKDLLLVKEKEGVLHVPITRSGDLSYESSVRCYTQSHSAQ-------VMEDFEERQ 2971
Query: 1947 EDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLPVGGQ-LGARFPTTKVTILA 2005
+S + F K + K C V I DDS++E EE F V L LP+G GAR + +
Sbjct: 2972 NADSSRITFLKGDKVKNCTVYIHDDSMFEPEEQFRVYLGLPLGNHWSGARIGKNNMATIT 3031
Query: 2006 DRYDE--PVLHFGDAEYHVNESA-----RYVEVCVWRRGTDLSQPSSIAVRSRKSEQESA 2058
DE P + F +A Y V E A + + V RRG D ++ S + +R SA
Sbjct: 3032 ISNDEDAPTIEFEEAAYQVREPAGPDAIAILNIKVIRRG-DQNRTSKVRCSTRDG---SA 3087
Query: 2059 EAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEKFELLL--QMPMGAVLGEP 2116
++G DY SR L F+PGV F+V IL + + E E F L+L P+ AVLG+
Sbjct: 3088 QSGVDYYPKSRVLKFSPGVDHIFFKVEILSNEDR---EWHESFSLVLGPDDPVEAVLGDV 3144
Query: 2117 NKTTIFIED 2125
T+ I D
Sbjct: 3145 TTATVTILD 3153
Score = 114 bits (285), Expect = 1e-24
Identities = 183/781 (23%), Positives = 301/781 (38%), Gaps = 158/781 (20%)
Query: 304 PPRPSFMATMMMEVDPLVLTALTPDALAAEDVESDPGDLVFNILNAPTHPPGH------- 356
PPR M + V ++ +L+ +D+++ +L+F + P H GH
Sbjct: 1957 PPR---MTLQPLRVQLSSGVVISNSSLSLQDLDTPDNELIFVLTKKPDH--GHVLWRQTA 2011
Query: 357 --PGQQGYVVSTDDPLGLPVSFFTQQELRELKIAYQPPAENSHGERLFQLELEVVDGDGA 414
P + G V+ + S FT Q++ + Y P + FQ L DG
Sbjct: 2012 SEPLENGRVL-------VQGSTFTYQDILAGLVGYVPSVPGMVVDE-FQFSLT----DGL 2059
Query: 415 ASDPFAFMVTVKSMNTLVPVASHNRGLVLFEGQSRPLSSTHSIPISDKDN---------L 465
D + + + P + N+GL L G ++ H + ++D D+
Sbjct: 2060 HVDTGRMKIYTELPASDTPHLAINQGLQLSAGSVARITEQH-LKVTDIDSDDHQVMYIMK 2118
Query: 466 EEVKMAAVRGLRHGQLVVFGAPAGCKYFTPADLAAGRVVYQHDGSNTYSDNIIFRME--- 522
E+ ++ ++HG L + FT AD++ G+ Y H G+ + F+ +
Sbjct: 2119 EDPGAGRLQMMKHGNLEQISIKGPIRSFTQADISQGQPEYSH-GTGEPGGSFAFKFDVVD 2177
Query: 523 -DGHHQVDFLFPLTILPVDDEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHF 581
+G+ +D F ++IL D PP++ TN GL L E V +I+ LSATD DS + + +
Sbjct: 2178 GEGNRLIDKSFSISILE-DKSPPVITTNKGLVLDENSVKKITTLQLSATDQDSGPTELIY 2236
Query: 582 VLENQPLKGNEEEPQWELAPGSSHSGHYLGDLLLQQAELPLSTEDED----WHYMEKEGL 637
+ QP G+ E +PG S DL + + S+E E + + +G+
Sbjct: 2237 RITRQPQLGHLEH---AASPGIQISSFTQADLTSRNVQYVHSSEAEKHSDAFSFTLSDGV 2293
Query: 638 YEKVVTEWLQRDIMEGRLFYRHLGPHSPQSVMVQLAFHVQDDHDPPNLSKQHIFTIKVQP 697
E T F I + P
Sbjct: 2294 SEVTQT-----------------------------------------------FHITLHP 2306
Query: 698 VDILSPQLYPGTTLEMTVQEYQLTHFQKNFLRYIDQDSDDQNLWYTLLTLPTDTDGNHQV 757
VD P + L M VQE + L+ +D D++ +++ +T++ P
Sbjct: 2307 VDDSLPVV---QNLGMRVQEGMRKTITEFELKAVDADTEAESVTFTIVQPP--------- 2354
Query: 758 RAGEIVLTDSPD--TLIMHFTQAQVNQHKVAYQPPQKLGIAPRVVQFTYQVEDAAG---- 811
R G I T + L FT + Q++V+Y + R FT+ V D
Sbjct: 2355 RHGTIERTSNGQHFHLTSTFTMKDIYQNRVSYSHDGSNSLKDR---FTFTVSDGTNPFFI 2411
Query: 812 ---------NSVPGTFTLFLQPVDNQPPE-VTNRGFAILE---GGSFNL-SSNELHVTDP 857
+ P F + + PVD+ P VTN G LE G + NL + EL DP
Sbjct: 2412 IEEGGKEIMTAAPQPFRVDILPVDDGTPRIVTNLGLQWLEYMDGKATNLITKKELLTMDP 2471
Query: 858 DTDIDQIVFILVRGPQHGHLQYFKRCMVPGESFMQADVINGSVSY-QHGRDQTTTSDTFH 916
DT+ Q+V+ + GP+HG ++ + +F Q DV G + Y H D+F
Sbjct: 2472 DTEDAQLVYEITTGPKHGFVENKLQPGRAAATFTQEDVNLGLIRYVLHKEKIREMMDSFQ 2531
Query: 917 LEVSDGVHHIPITIPISVHPNVANRSP-RISLRSSSLLDVSIDVLENKATEITMGVIHGK 975
V D PNV + + I S S +V E KA +++ V
Sbjct: 2532 FLVKDS------------KPNVVSDNVFHIQWSLISFKYTSYNVSE-KAGSVSVTV---- 2574
Query: 976 RKDVGDLMLSFIVKDSPKLGTILVNGLPTERFTQEDLINGRVAYAHTAGEVGFQKQHDAF 1035
+ G+L IV + GT + + + Q+D Y AG+V F ++ D
Sbjct: 2575 -QRTGNLNQYAIVLCRTEQGTASSSSRVSSQPGQQD-------YVEYAGQVQFDEREDTK 2626
Query: 1036 S 1036
S
Sbjct: 2627 S 2627
Score = 47.8 bits (112), Expect = 1e-04
Identities = 29/103 (28%), Positives = 56/103 (54%), Gaps = 3/103 (2%)
Query: 1791 LEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWRVRIIPDNE 1850
L + + RRG TS + T+D +A+ D+ + ++ ++F+PG ++V I+ + +
Sbjct: 3062 LNIKVIRRGDQNRTSKVRCSTRDGSAQSGVDY-YPKSRVLKFSPGVDHIFFKVEILSNED 3120
Query: 1851 YETSETFQIILS--EPLMAVLEFPEMATVEIVDPGDESTVYIP 1891
E E+F ++L +P+ AVL ATV I+D ++ +P
Sbjct: 3121 REWHESFSLVLGPDDPVEAVLGDVTTATVTILDQEAAGSLILP 3163
>gi|47419930 chondroitin sulfate proteoglycan 4 [Homo sapiens]
Length = 2322
Score = 203 bits (516), Expect = 2e-51
Identities = 256/1044 (24%), Positives = 428/1044 (40%), Gaps = 109/1044 (10%)
Query: 765 TDSPDTLIMHFTQAQVNQHKVAYQPPQKLGIAPRV-VQFTYQVE---DAAGNSVPGTFTL 820
T T++ FT + + ++ YQ + T Q E D A V G F +
Sbjct: 950 TQDKTTMVTSFTNEDLLRGRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRGVFRV 1009
Query: 821 FLQPV-DNQPPEVTNRGFAILEGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQ-HGHLQ 878
+QPV D+ P + +R F + GG L+++++ +D D+ +L R G +
Sbjct: 1010 AIQPVNDHAPVQTISRIFHVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKDLLFGSIV 1069
Query: 879 YFKRCMVPGESFMQADVINGSVSYQH-GRDQTTTSDTFHLEVSDGVHHIPITIPISVHPN 937
P F Q D+ V + H G D+ L+VSDG H + +
Sbjct: 1070 AVDEPTRPIYRFTQEDLRKRRVLFVHSGADR----GWIQLQVSDGQHQATALLEVQAS-- 1123
Query: 938 VANRSPRISLRSSSLLDVSIDVLENKATEITMGVIH-GKRKDV--GDLMLSFIVKDSPKL 994
P + + + S S+ V + I V+H D+ GD + + V P+
Sbjct: 1124 ----EPYLRVANGS----SLVVPQGGQGTIDTAVLHLDTNLDIRSGD-EVHYHVTAGPRW 1174
Query: 995 GTILVNGLPTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIE 1054
G ++ G P F+Q+DL++G V Y+H G D + V +
Sbjct: 1175 GQLVRAGQPATAFSQQDLLDGAVLYSHN----GSLSPRDTMAFS--------VEAGPVHT 1222
Query: 1055 KVQVQVTVLPVDNVGPKVLVGESFI-VYEGEKNSLTLQHLHVEDVDTHQDELLCTVTSQP 1113
+QVT+ + P LV I V++GE + L +++ +V S P
Sbjct: 1223 DATLQVTIALEGPLAPLKLVRHKKIYVFQGEAAEIRRDQLEAAQEAVPPADIVFSVKSPP 1282
Query: 1114 ASGYLEKIASAPGSKMSQSGSPISAFSLRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDG 1173
++GYL ++ + S P+ +FS + + Y +H E D F+ + G
Sbjct: 1283 SAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVLY---LHSRPEAWSDAFSLDVASG 1339
Query: 1174 INFS-PNVFFPIIILPTNDEQPKLFAHEFKVLEGMSLVIDTQLLNGADADLPPN-ELHFQ 1231
+ V + +LP L A F V EG SL + LL + P L Q
Sbjct: 1340 LGAPLEGVLVELEVLPA---AIPLEAQNFSVPEGGSLTLAPPLLRVSGPYFPTLLGLSLQ 1396
Query: 1232 LTALPRHGRIIQQLATGSQPIHSFTLKEIQEASTIVYEHDDSETKEDSFEVWLSDGKHTT 1291
+ P+HG + ++ ++ + +F+ + ++E I Y HD SET DSF V +++
Sbjct: 1397 VLEPPQHGALQKEDGPQARTLSAFSWRMVEE-QLIRYVHDGSETLTDSF-VLMANASEMD 1454
Query: 1292 HRKVPIVVTL----VDDETPHLTVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLH 1347
+ P+ T+ V+D+ P LT N GL++ +G + I L++TD DS + L + +
Sbjct: 1455 RQSHPVAFTVTVLPVNDQPPILTTNTGLQMWEGATAPIPAEALRSTDGDSGSEDLVYTIE 1514
Query: 1348 SGPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEINRGLICYIHTGQEGIVDIIKFDVTDGV 1407
P G + P EVR +FTQ +++ GL+ + H G + +F ++DG
Sbjct: 1515 Q-PSNGRVVLRGAPGTEVR-------SFTQAQLDGGLVLFSHRGT--LDGGFRFRLSDGE 1564
Query: 1408 NTLTDHYFYVTIGNLDSVFPEVISKRITLIEGARVTLTNNLLTNSDINSSDEH--HFSIT 1465
+T H+F VT + S+ +T+ G+ L++ L S +D + +
Sbjct: 1565 HTSPGHFFRVT-AQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRASSSAGTDPQLLLYRVV 1623
Query: 1466 RAPSLGHL--ESSDYAGEPIASFTQLQLASNKISYVHTSNDE---KKMDSFEFQVIG-EL 1519
R P LG L D GE + +FTQ ++ + I Y H E + D+ E Q+
Sbjct: 1624 RGPQLGRLFHAQQDSTGEALVNFTQAEVYAGNILYEHEMPPEPFWEAHDTLELQLSSPPA 1683
Query: 1520 YPVFRTFRIFITDVDNKKPILTIH---------------RLTLQKEDSQLITLLELTVED 1564
V T + ++ + P H R+T+ D+ + L +V
Sbjct: 1684 RDVAATLAVAVS-FEAACPQRPSHLWKNKGLWVPEGQRARITVAALDA---SNLLASVPS 1739
Query: 1565 SDTPDDLILFTITQVPMHGKILYNGSRPVTT----FTKQDLNKNLISYKHDGSETTEDSF 1620
+ +LF +TQ P G++L + P+ F + L + Y H G T +D F
Sbjct: 1740 PQRSEHDVLFQVTQFPSRGQLLVS-EEPLHAGQPHFLQSQLAAGQLVYAHGGGGTQQDGF 1798
Query: 1621 SLTV-TDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKRLHTGHM 1679
G P T+ + + +R ++ R PQ A RL G
Sbjct: 1799 HFRAHLQGPAGASVAGPQTS------EAFAITVRDVNERPPQ----PQASVPLRLTRGSR 1848
Query: 1680 GFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGNQSTRVFTQADIDEMKISYV 1739
I+ L D DS ++Y+V R P +GF+ G G FTQAD+D ++++V
Sbjct: 1849 A-PISRAQLSVVDPDSAPGEIEYEVQRAPHNGFLSLVGGGLGPVTRFTQADVDSGRLAFV 1907
Query: 1740 LNEGSNASKDIFYFSVEDNGGNKL 1763
N S A IF S+ D L
Sbjct: 1908 ANGSSVAG--IFQLSMSDGASPPL 1929
Score = 178 bits (452), Expect = 4e-44
Identities = 281/1166 (24%), Positives = 483/1166 (41%), Gaps = 161/1166 (13%)
Query: 641 VVTEWLQRDIMEGRLFYRHLGPHSPQSVMVQLAFHV-QDDHDPPNLSKQHIFTIKVQPVD 699
+VT + D++ GRL Y+H + + + +A + D + +F + +QPV+
Sbjct: 956 MVTSFTNEDLLRGRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRGVFRVAIQPVN 1015
Query: 700 ILSPQLYPGTTLEMTVQEYQLTHFQKNFLRYIDQD----SDDQNLWYTLLTLPTDTDGNH 755
+P T+ ++ H + R + D SD + + + T D
Sbjct: 1016 DHAPV--------QTIS--RIFHVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKD--- 1062
Query: 756 QVRAGEIVLTDSPDTLIMHFTQAQVNQHKVAYQPPQKLGIAPRVVQFTYQVEDAAGNSVP 815
+ G IV D P I FTQ + + +V + G +Q QV D +
Sbjct: 1063 -LLFGSIVAVDEPTRPIYRFTQEDLRKRRVLF---VHSGADRGWIQL--QVSDGQHQA-- 1114
Query: 816 GTFTLFLQPVDNQPPEVTNRGFAILEGGSFNLSSNELHVTDPDTDI---DQIVFILVRGP 872
T L +Q + + +GG + + LH+ D + DI D++ + + GP
Sbjct: 1115 -TALLEVQASEPYLRVANGSSLVVPQGGQGTIDTAVLHL-DTNLDIRSGDEVHYHVTAGP 1172
Query: 873 QHGHLQYFKRCMVPGESFMQADVINGSVSYQHGRDQTTTSDTFHLEVSDGVHHIPITIPI 932
+ G L R P +F Q D+++G+V Y H + DT V G H T+ +
Sbjct: 1173 RWGQL---VRAGQPATAFSQQDLLDGAVLYSH-NGSLSPRDTMAFSVEAGPVHTDATLQV 1228
Query: 933 SVHPNVANRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDVGDLMLSFIVKDSP 992
+ +A P L+ + I V + +A EI + ++ V + F VK P
Sbjct: 1229 T----IALEGPLAPLK--LVRHKKIYVFQGEAAEIRRDQLEAAQEAVPPADIVFSVKSPP 1282
Query: 993 KLGTILVNGL-----------PTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILSK 1041
G +++ P + F+QE + GRV Y H+ E DAFSL ++
Sbjct: 1283 SAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVLYLHSRPEA----WSDAFSLDVAS 1338
Query: 1042 DSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVLVGESFIVYEGEKNSLTLQHLHVEDVDTH 1101
+ +E V V++ VLP L ++F V EG SLTL + +
Sbjct: 1339 GL------GAPLEGVLVELEVLP----AAIPLEAQNFSVPEG--GSLTLAPPLLRVSGPY 1386
Query: 1102 QDELL---CTVTSQPASGYLEKIASAPGSKMSQSGSPISAFSLRDIQVRHINYVQSIHKG 1158
LL V P G L+K + +SAFS R ++ + I YV H G
Sbjct: 1387 FPTLLGLSLQVLEPPQHGALQK-------EDGPQARTLSAFSWRMVEEQLIRYV---HDG 1436
Query: 1159 VEPQEDQFTFY--CSDGINFSPNVFFPIIILPTNDEQPKLFAHE-FKVLEGMSLVIDTQL 1215
E D F S+ S V F + +LP ND+ P L + ++ EG + I +
Sbjct: 1437 SETLTDSFVLMANASEMDRQSHPVAFTVTVLPVNDQPPILTTNTGLQMWEGATAPIPAEA 1496
Query: 1216 LNGADADLPPNELHFQLTALPRHGRIIQQLATGSQPIHSFTLKEIQEASTIVYEHDDSET 1275
L D D +L + + P +GR++ + A G++ + SFT ++ + +++ H T
Sbjct: 1497 LRSTDGDSGSEDLVYTIEQ-PSNGRVVLRGAPGTE-VRSFTQAQL-DGGLVLFSH--RGT 1551
Query: 1276 KEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHLTVNNGLKVEKGHSEIITNRILKA-TD 1334
+ F LSDG+HT+ VT L + L V G + ++++ L+A +
Sbjct: 1552 LDGGFRFRLSDGEHTSPGHF-FRVTAQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRASSS 1610
Query: 1335 LDSDDKSLSFVLHSGPQQG-LLQRLRKPRGEVRNNLTLGMNFTQDEINRGLICYIHTGQE 1393
+D + L + + GPQ G L + GE +NFTQ E+ G I Y H
Sbjct: 1611 AGTDPQLLLYRVVRGPQLGRLFHAQQDSTGEAL------VNFTQAEVYAGNILYEHEMPP 1664
Query: 1394 ----GIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEVIS-----KRITLIEGARVTL 1444
D ++ ++ V + + ++ P+ S K + + EG R +
Sbjct: 1665 EPFWEAHDTLELQLSSPPARDVAATLAVAV-SFEAACPQRPSHLWKNKGLWVPEGQRARI 1723
Query: 1445 T------NNLLTNSDINSSDEHH--FSITRAPSLGHLESSD---YAGEPIASFTQLQLAS 1493
T +NLL + EH F +T+ PS G L S+ +AG+P F Q QLA+
Sbjct: 1724 TVAALDASNLLASVPSPQRSEHDVLFQVTQFPSRGQLLVSEEPLHAGQP--HFLQSQLAA 1781
Query: 1494 NKISYVHTSNDEKKMDSFEFQ----------VIGELYPVFRTFRIFITDVDNKKPILTIH 1543
++ Y H ++ D F F+ V G F I + DV+ + P
Sbjct: 1782 GQLVYAHGGGGTQQ-DGFHFRAHLQGPAGASVAGP--QTSEAFAITVRDVNERPPQPQAS 1838
Query: 1544 -RLTLQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHG--KILYNGSRPVTTFTKQD 1600
L L + I+ +L+V D D+ I + + + P +G ++ G PVT FT+ D
Sbjct: 1839 VPLRLTRGSRAPISRAQLSVVDPDSAPGEIEYEVQRAPHNGFLSLVGGGLGPVTRFTQAD 1898
Query: 1601 LNKNLISYKHDGSETTEDSFSLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLP 1660
++ +++ +GS + F L+++DG LP + P + VQ+R+ +P
Sbjct: 1899 VDSGRLAFVANGS-SVAGIFQLSMSDGASPP---LPMSLAVDILPSAIEVQLRA-PLEVP 1953
Query: 1661 QITTNRGAPALKRLHTGHMGFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGLGN 1720
Q AL R + S D++ P Y++ +GP++G ++ +G
Sbjct: 1954 Q--------ALGRSSLSQQQLRVVS------DREEPE--AAYRLIQGPQYGHLL---VGG 1994
Query: 1721 QSTRVFTQADIDEMKISYVLNEGSNA 1746
+ T F+Q ID+ ++ + S++
Sbjct: 1995 RPTSAFSQFQIDQGEVVFAFTNFSSS 2020
Score = 129 bits (323), Expect = 4e-29
Identities = 204/908 (22%), Positives = 368/908 (40%), Gaps = 111/908 (12%)
Query: 868 LVRGPQHGHLQYFKRCMVPGESFMQADVINGSVSY-QHGRDQTTTSDTFHLEVSDGVHHI 926
+V+ P+ G+LQ + G+ F Q D+ G V+Y R DTF V+ +
Sbjct: 825 VVQAPRKGNLQLQGTRLSDGQGFTQDDIQAGRVTYGATARASEAVEDTFRFRVTAPPYFS 884
Query: 927 PI-TIPISVHPNVANRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDVGDLMLS 985
P+ T PI + P + ++ LL V + E + H K +
Sbjct: 885 PLYTFPIHI-----GGDPDAPVLTNVLLVVP------EGGEGVLSADHLFVKSLNSASYL 933
Query: 986 FIVKDSPKLGTILVNGLPTE-----RFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILS 1040
+ V + P+ G + G + FT EDL+ GR+ Y H E D + +
Sbjct: 934 YEVMERPRHGRLAWRGTQDKTTMVTSFTNEDLLRGRLVYQHDDSET----TEDDIPFVAT 989
Query: 1041 KDSYQWVVGNSIIEKVQ--VQVTVLPVDNVGPKVLVGESFIVYEGEKNSLTLQHLHVEDV 1098
+ G+ E+V+ +V + PV++ P + F V G + LT + D
Sbjct: 990 RQGES--SGDMAWEEVRGVFRVAIQPVNDHAPVQTISRIFHVARGGRRLLTTDDVAFSDA 1047
Query: 1099 DT-HQDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFSLRDIQVRHINYVQSIHK 1157
D+ D L G + + + PI F+ D++ R + +V H
Sbjct: 1048 DSGFADAQLVLTRKDLLFGSIVAV--------DEPTRPIYRFTQEDLRKRRVLFV---HS 1096
Query: 1158 GVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEFKVLEGMSLV------- 1210
G + SDG + + +L +P L +V G SLV
Sbjct: 1097 GAD--RGWIQLQVSDGQHQA------TALLEVQASEPYL-----RVANGSSLVVPQGGQG 1143
Query: 1211 -IDTQLLNGADADL---PPNELHFQLTALPRHGRIIQQLATGSQPIHSFTLKEIQEASTI 1266
IDT +L+ D +L +E+H+ +TA PR G QL QP +F+ +++ + + +
Sbjct: 1144 TIDTAVLH-LDTNLDIRSGDEVHYHVTAGPRWG----QLVRAGQPATAFSQQDLLDGA-V 1197
Query: 1267 VYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETP-HLTVNNGLKVEKGHSEII 1325
+Y H+ S + D+ + G T + + + L P L + + V +G + I
Sbjct: 1198 LYSHNGSLSPRDTMAFSVEAGPVHTDATLQVTIALEGPLAPLKLVRHKKIYVFQGEAAEI 1257
Query: 1326 TNRILKATDLDSDDKSLSFVLHSGPQQGLLQRL-RKPRGEVRNNLTLGMNFTQDEINRGL 1384
L+A + F + S P G L + R + +L +F+Q+ ++ G
Sbjct: 1258 RRDQLEAAQEAVPPADIVFSVKSPPSAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGR 1317
Query: 1385 ICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEVISKRITLIEGARVTL 1444
+ Y+H+ E D DV G+ + V + L + P + ++ ++ EG +TL
Sbjct: 1318 VLYLHSRPEAWSDAFSLDVASGLGAPLEGVL-VELEVLPAAIP-LEAQNFSVPEGGSLTL 1375
Query: 1445 TNNLLTNSD--INSSDEHHFSITRAPSLGHLESSD-YAGEPIASFTQLQLASNKISYVHT 1501
LL S + + P G L+ D +++F+ + I YVH
Sbjct: 1376 APPLLRVSGPYFPTLLGLSLQVLEPPQHGALQKEDGPQARTLSAFSWRMVEEQLIRYVH- 1434
Query: 1502 SNDEKKMDSFEF-----QVIGELYPVFRTFRIFITDVDNKKPILTIHR-LTLQKEDSQLI 1555
E DSF ++ + +PV F + + V+++ PILT + L + + + I
Sbjct: 1435 DGSETLTDSFVLMANASEMDRQSHPV--AFTVTVLPVNDQPPILTTNTGLQMWEGATAPI 1492
Query: 1556 TLLELTVEDSDTPDDLILFTITQVPMHGKILYNGS--RPVTTFTKQDLNKNLISYKHDGS 1613
L D D+ + +++TI Q P +G+++ G+ V +FT+ L+ L+ + H G
Sbjct: 1493 PAEALRSTDGDSGSEDLVYTIEQ-PSNGRVVLRGAPGTEVRSFTQAQLDGGLVLFSHRG- 1550
Query: 1614 ETTEDSFSLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKR 1673
T + F ++DG HT P + + + ++ +T G+
Sbjct: 1551 -TLDGGFRFRLSDGEHTS----PGHFFRVTAQKQVLLSLKGSQT----LTVCPGSVQ--- 1598
Query: 1674 LHTGHMGFLITSKSLKAEDQ-DSPHRLLKYKVTRGPEHG--FIIKTGLGNQSTRVFTQAD 1730
++S++L+A + +LL Y+V RGP+ G F + ++ FTQA+
Sbjct: 1599 --------PLSSQTLRASSSAGTDPQLLLYRVVRGPQLGRLFHAQQDSTGEALVNFTQAE 1650
Query: 1731 IDEMKISY 1738
+ I Y
Sbjct: 1651 VYAGNILY 1658
Score = 116 bits (290), Expect = 3e-25
Identities = 213/973 (21%), Positives = 374/973 (38%), Gaps = 117/973 (12%)
Query: 822 LQPVDNQPPEVTNRG--FAILEGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQY 879
+ PV++ P + G ILE L DPD+ + + F ++ ++
Sbjct: 546 VNPVNDPPHIIFPHGSLMVILEHTQKPLGPEVFQAYDPDSACEGLTFQVLGTSSGLPVER 605
Query: 880 FKRCMVPGESFMQADVINGSVSYQHGRDQTTTSDTFHLEVSDGVHHIPITIPISVHPNVA 939
+ P F ++ GS+ Y H R TF VSDG+ P P ++ V
Sbjct: 606 RDQPGEPATEFSCRELEAGSLVYVH-RGGPAQDLTFR--VSDGLQASP---PATL--KVV 657
Query: 940 NRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDVG-DLMLSFIVKDSPKLGTIL 998
P I + S+ L ++ + A I + + VG D+ + F V + + G +
Sbjct: 658 AIRPAIQIHRSTGLRLA----QGSAMPILPANLSVETNAVGQDVSVLFRVTGALQFGELQ 713
Query: 999 VNGL---------PTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILSKDSYQWVVG 1049
G T+ F Q D+ GRV Y T QH A+ + + + VG
Sbjct: 714 KQGAGGVEGAEWWATQAFHQRDVEQGRVRYLST------DPQHHAYDTV-ENLALEVQVG 766
Query: 1050 NSIIEKVQVQVTVLPVDNVGPKVLVGESFIVYEGEKNSLTLQHLH--VEDVDTHQDELLC 1107
I+ + VT + +L E ++ +LT HL +E+
Sbjct: 767 QEILSNLSFPVT---IQRATVWMLRLEPLHTQNTQQETLTTAHLEATLEEAGPSPPTFHY 823
Query: 1108 TVTSQPASGYLEKIASAPGSKMSQSGSPISAFSLRDIQVRHINYVQSIHKGVEPQEDQFT 1167
V P G L+ G+++S F+ DIQ + Y + + E ED F
Sbjct: 824 EVVQAPRKGNLQ----LQGTRLSDG----QGFTQDDIQAGRVTY-GATARASEAVEDTFR 874
Query: 1168 FYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEFKVLEGMSLVIDTQLLNGADADLPPNE 1227
F + FSP FPI I + + P L V EG V+ L L
Sbjct: 875 FRVTAPPYFSPLYTFPIHI-GGDPDAPVLTNVLLVVPEGGEGVLSADHL--FVKSLNSAS 931
Query: 1228 LHFQLTALPRHGRIIQQLATGSQP----IHSFTLKEIQEASTIVYEHDDSETKEDSFE-V 1282
+++ PRHGR+ + G+Q + SFT +++ +VY+HDDSET ED V
Sbjct: 932 YLYEVMERPRHGRLAWR---GTQDKTTMVTSFTNEDLLR-GRLVYQHDDSETTEDDIPFV 987
Query: 1283 WLSDGKHT-------THRKVPIVVTLVDDETPHLTVNNGLKVEKGHSEIITNRILKATDL 1335
G+ + + + V+D P T++ V +G ++T + +D
Sbjct: 988 ATRQGESSGDMAWEEVRGVFRVAIQPVNDHAPVQTISRIFHVARGGRRLLTTDDVAFSDA 1047
Query: 1336 DSDDKSLSFVL-HSGPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEINRGLICYIHTGQEG 1394
DS VL G + + +P + FTQ+++ + + ++H+G +
Sbjct: 1048 DSGFADAQLVLTRKDLLFGSIVAVDEPTRPI-------YRFTQEDLRKRRVLFVHSGADR 1100
Query: 1395 IVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEVISKRITLIEGARVTLTNNLL---TN 1451
I+ V+DG + T + + + + + +G + T+ +L TN
Sbjct: 1101 --GWIQLQVSDGQHQAT---ALLEVQASEPYLRVANGSSLVVPQGGQGTIDTAVLHLDTN 1155
Query: 1452 SDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQLQLASNKISYVHTSNDEKKMDSF 1511
DI S DE H+ +T P G L AG+P +F+Q L + Y H + + D+
Sbjct: 1156 LDIRSGDEVHYHVTAGPRWGQLVR---AGQPATAFSQQDLLDGAVLYSHNGSLSPR-DTM 1211
Query: 1512 EFQVIGELYPVFRTFRIFITDVDNKKPILTIH--RLTLQKEDSQLITLLELTVEDSDTPD 1569
F V T ++ I P+ + ++ + + ++ I +L P
Sbjct: 1212 AFSVEAGPVHTDATLQVTIALEGPLAPLKLVRHKKIYVFQGEAAEIRRDQLEAAQEAVPP 1271
Query: 1570 DLILFTITQVPMHGKILY----------NGSRPVTTFTKQDLNKNLISYKHDGSETTEDS 1619
I+F++ P G ++ PV +F+++ ++ + Y H E D+
Sbjct: 1272 ADIVFSVKSPPSAGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVLYLHSRPEAWSDA 1331
Query: 1620 FSLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSLDNRLPQITTNRGAPALKRLHTGHM 1679
FSL V G + L + + + + + +P+ + AP L R+ +
Sbjct: 1332 FSLDVASGLGAPL----EGVLVELEVLPAAIPLEAQNFSVPEGGSLTLAPPLLRVSGPYF 1387
Query: 1680 GFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIK-TGLGNQSTRVFTQADIDEMKISY 1738
L+ L +V P+HG + K G ++ F+ ++E I Y
Sbjct: 1388 PTLLG---------------LSLQVLEPPQHGALQKEDGPQARTLSAFSWRMVEEQLIRY 1432
Query: 1739 VLNEGSNASKDIF 1751
V ++GS D F
Sbjct: 1433 V-HDGSETLTDSF 1444
Score = 103 bits (256), Expect = 2e-21
Identities = 157/711 (22%), Positives = 286/711 (40%), Gaps = 112/711 (15%)
Query: 357 PGQQGYVVSTDDPLGLPVSFFTQQELRELKIAYQPPAENSHGERLFQLELEVVDGDGAAS 416
P Q G + D P +S F+ + + E I Y + + F L + D S
Sbjct: 1400 PPQHGALQKEDGPQARTLSAFSWRMVEEQLIRYVHDGSETLTDS-FVLMANASEMD-RQS 1457
Query: 417 DPFAFMVTVKSMNTLVPVASHNRGLVLFEGQSRPLSSTHSIPISDKDNLEEVKMAAVRGL 476
P AF VTV +N P+ + N GL ++EG + P+ + ++ +D D+ E + +
Sbjct: 1458 HPVAFTVTVLPVNDQPPILTTNTGLQMWEGATAPIPA-EALRSTDGDSGSEDLVYTIEQP 1516
Query: 477 RHGQLVVFGAPAG-CKYFTPADLAAGRVVYQHDGSNTYSDNIIFRMEDGHHQVDFLFPLT 535
+G++V+ GAP + FT A L G V++ H G T FR+ DG H P
Sbjct: 1517 SNGRVVLRGAPGTEVRSFTQAQLDGGLVLFSHRG--TLDGGFRFRLSDGEHTS----PGH 1570
Query: 536 ILPVDDEPPMVNTNTG---LSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQPLKGNE 592
V + ++ + G L++ G V +S L A+ D + L + ++G
Sbjct: 1571 FFRVTAQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRASSSAGTDPQL---LLYRVVRG-- 1625
Query: 593 EEPQWELAPGSSHSGHYLGDLLLQQAELPLSTEDEDWHYMEKEGLYEKVVTEWLQRDIME 652
PQ LG L Q + ST + + + Q ++
Sbjct: 1626 --PQ-------------LGRLFHAQQD---STGE--------------ALVNFTQAEVYA 1653
Query: 653 GRLFYRHLGPHSPQSVMVQLAFHVQDDHDPPNLSKQHIFTIKVQPVDILSPQLYPGTTLE 712
G + Y H P P + HD L + P ++ L + E
Sbjct: 1654 GNILYEHEMPPEP----------FWEAHDTLELQ------LSSPPARDVAATLAVAVSFE 1697
Query: 713 MTVQEYQLTHFQKNFLRYIDQDS---------DDQNLWYTLLTLPTDTDGNHQV------ 757
+ + +H KN ++ + D NL L ++P+ H V
Sbjct: 1698 AACPQ-RPSHLWKNKGLWVPEGQRARITVAALDASNL---LASVPSPQRSEHDVLFQVTQ 1753
Query: 758 --RAGEIVLTDSP-DTLIMHFTQAQVNQHKVAYQPPQKLGIAPRVVQFTYQVEDAAGNSV 814
G++++++ P HF Q+Q+ ++ Y G F ++ AG SV
Sbjct: 1754 FPSRGQLLVSEEPLHAGQPHFLQSQLAAGQLVYAHGGG-GTQQDGFHFRAHLQGPAGASV 1812
Query: 815 PG-----TFTLFLQPVDNQPPEV-TNRGFAILEGGSFNLSSNELHVTDPDTDIDQIVFIL 868
G F + ++ V+ +PP+ + + G +S +L V DPD+ +I + +
Sbjct: 1813 AGPQTSEAFAITVRDVNERPPQPQASVPLRLTRGSRAPISRAQLSVVDPDSAPGEIEYEV 1872
Query: 869 VRGPQHGHLQYFKRCMVPGESFMQADVINGSVSYQHGRDQTTTSDTFHLEVSDGVH-HIP 927
R P +G L + P F QADV +G +++ + ++ + F L +SDG +P
Sbjct: 1873 QRAPHNGFLSLVGGGLGPVTRFTQADVDSGRLAFV--ANGSSVAGIFQLSMSDGASPPLP 1930
Query: 928 ITIPISVHPNVANRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDVGDLMLSFI 987
+++ + + P+ I ++ + L+V + + ++ + V+ + + ++
Sbjct: 1931 MSLAVDILPSA------IEVQLRAPLEVPQALGRSSLSQQQLRVVSDREEPEA----AYR 1980
Query: 988 VKDSPKLGTILVNGLPTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLI 1038
+ P+ G +LV G PT F+Q + G V +A T F HD F ++
Sbjct: 1981 LIQGPQYGHLLVGGRPTSAFSQFQIDQGEVVFAFT----NFSSSHDHFRVL 2027
Score = 102 bits (253), Expect = 5e-21
Identities = 216/981 (22%), Positives = 375/981 (38%), Gaps = 175/981 (17%)
Query: 832 VTNRGFAILEGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQYFKR--------C 883
V ++ + +G + + ++L IVF + P G+L R
Sbjct: 1242 VRHKKIYVFQGEAAEIRRDQLEAAQEAVPPADIVFSVKSPPSAGYLVMVSRGALADEPPS 1301
Query: 884 MVPGESFMQADVINGSVSYQHGRDQTTTSDTFHLEVSDGV-----------HHIPITIPI 932
+ P +SF Q V G V Y H R + SD F L+V+ G+ +P IP+
Sbjct: 1302 LDPVQSFSQEAVDTGRVLYLHSRPEAW-SDAFSLDVASGLGAPLEGVLVELEVLPAAIPL 1360
Query: 933 SVHPNVANRSPRISLRSS----------SLLDVSIDVLENKATEITMGVIHGKRKDVGDL 982
++L +LL +S+ VLE HG +
Sbjct: 1361 EAQNFSVPEGGSLTLAPPLLRVSGPYFPTLLGLSLQVLEPPQ--------HGALQK---- 1408
Query: 983 MLSFIVKDSPKLGTILVNGLPTERFTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILSKD 1042
+D P+ T+ R +E LI Y H E D+F L+ +
Sbjct: 1409 ------EDGPQARTLSAFSW---RMVEEQLIR----YVHDGSET----LTDSFVLMANAS 1451
Query: 1043 SYQWVVGNSIIEKVQVQVTVLPVDNVGPKVLVGESFIVYEGEKNSLTLQHLHVEDVDTHQ 1102
+ V VTVLPV++ P + ++EG + + L D D+
Sbjct: 1452 EM-----DRQSHPVAFTVTVLPVNDQPPILTTNTGLQMWEGATAPIPAEALRSTDGDSGS 1506
Query: 1103 DELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFSLRDIQVRHINYVQSIHKGVEPQ 1162
++L+ T+ QP++G + + APG++ + +F+ + V H+G
Sbjct: 1507 EDLVYTI-EQPSNGRVV-LRGAPGTE-------VRSFTQAQLDG---GLVLFSHRGT--L 1552
Query: 1163 EDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLF---AHEFKVLEGMSLVIDTQLLNGA 1219
+ F F SDG + SP FF + T +Q L + V G + +Q L +
Sbjct: 1553 DGGFRFRLSDGEHTSPGHFFRV----TAQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRAS 1608
Query: 1220 D-ADLPPNELHFQLTALPRHGRII--QQLATGSQPIHSFTLKEIQEASTIVYEHDDSETK 1276
A P L +++ P+ GR+ QQ +TG + + +FT E+ A I+YEH+
Sbjct: 1609 SSAGTDPQLLLYRVVRGPQLGRLFHAQQDSTG-EALVNFTQAEVY-AGNILYEHEMPPEP 1666
Query: 1277 ----EDSFEVWLSDGKHTTHRKVPIVVTLVDDETP----HLTVNNGLKVEKGHSEIITNR 1328
D+ E+ LS V + P HL N GL V +G IT
Sbjct: 1667 FWEAHDTLELQLSSPPARDVAATLAVAVSFEAACPQRPSHLWKNKGLWVPEGQRARITVA 1726
Query: 1329 ILKATDL-------DSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNLTLGM-NFTQDEI 1380
L A++L + + F + P +G L +P L G +F Q ++
Sbjct: 1727 ALDASNLLASVPSPQRSEHDVLFQVTQFPSRGQLLVSEEP-------LHAGQPHFLQSQL 1779
Query: 1381 NRGLICYIHTG----QEGIVDIIKFDVTDGVNTL---TDHYFYVTIGNLDSVFPEV-ISK 1432
G + Y H G Q+G G + T F +T+ +++ P+ S
Sbjct: 1780 AAGQLVYAHGGGGTQQDGFHFRAHLQGPAGASVAGPQTSEAFAITVRDVNERPPQPQASV 1839
Query: 1433 RITLIEGARVTLTNNLLTNSDINSSD-EHHFSITRAPSLGHLESSDYAGEPIASFTQLQL 1491
+ L G+R ++ L+ D +S+ E + + RAP G L P+ FTQ +
Sbjct: 1840 PLRLTRGSRAPISRAQLSVVDPDSAPGEIEYEVQRAPHNGFLSLVGGGLGPVTRFTQADV 1899
Query: 1492 ASNKISYVHTSNDEKKMDSFEFQVI-GELYPVFRTFRIFI----TDVDNKKPILTIHRLT 1546
S ++++V +N F+ + G P+ + + I +V + P+ L
Sbjct: 1900 DSGRLAFV--ANGSSVAGIFQLSMSDGASPPLPMSLAVDILPSAIEVQLRAPLEVPQALG 1957
Query: 1547 LQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHGKILYNGSRPVTTFTKQDLNKNLI 1606
Q + + V D + P+ + + Q P +G +L G RP + F++ +++
Sbjct: 1958 RSSLSQQQLRV----VSDREEPE--AAYRLIQGPQYGHLLV-GGRPTSAFSQFQIDQG-- 2008
Query: 1607 SYKHDGSETTEDSFSLTVTDGTHTDFYVLPDTALATHKPQVMRVQIRSL-----DNRLPQ 1661
E F+ T +H F VL A + V+ V +R+L PQ
Sbjct: 2009 ----------EVVFAFTNFSSSHDHFRVLA-LARGVNASAVVNVTVRALLHVWAGGPWPQ 2057
Query: 1662 ITTNRGAPALKRLHTGHMGFLITSKSLKAEDQDSPHRLLKYKVTRGPEHGFIIKTGL--- 1718
T R P + L G + + + ++++ GP HG +++
Sbjct: 2058 GATLRLDPTV--LDAGELA-------------NRTGSVPRFRLLEGPRHGRVVRVPRART 2102
Query: 1719 ---GNQSTRVFTQADIDEMKI 1736
G+Q FTQ D+++ ++
Sbjct: 2103 EPGGSQLVEQFTQQDLEDGRL 2123
Score = 101 bits (252), Expect = 7e-21
Identities = 162/699 (23%), Positives = 282/699 (40%), Gaps = 64/699 (9%)
Query: 1071 KVLVGESFIVYEGEKNSLTLQH----LHVEDVDTHQDELLCTVTSQPASGYLE-KIASAP 1125
++L +V EG L +H L + + + + ++L +VT G LE I A
Sbjct: 430 QLLTISPLVVAEGGTAWLEWRHVQPTLDLMEAELRKSQVLFSVTRGARHGELELDIPGAQ 489
Query: 1126 GSKMSQSGSPISAFSLRDIQVRHINYVQSIHKGVEPQEDQFTFYCS--------DGINFS 1177
KM F+L D+ R + IH G E DQ S +
Sbjct: 490 ARKM---------FTLLDVVNRKARF---IHDGSEDTSDQLVLEVSVTARVPMPSCLRRG 537
Query: 1178 PNVFFPIIILPTNDEQPKLFAHE--FKVLEGMSLVIDTQLLNGADADLPPNELHFQLTAL 1235
PI + P ND +F H +LE + ++ D D L FQ+
Sbjct: 538 QTYLLPIQVNPVNDPPHIIFPHGSLMVILEHTQKPLGPEVFQAYDPDSACEGLTFQVLGT 597
Query: 1236 PRHGRIIQQLATGSQPIHSFTLKEIQEASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKV 1295
G +++ +P F+ +E+ EA ++VY H ++ +F V SDG +
Sbjct: 598 SS-GLPVERRDQPGEPATEFSCREL-EAGSLVYVHRGGPAQDLTFRV--SDGLQASPPAT 653
Query: 1296 PIVVTLVDDETPHLTVNNGLKVEKGHS-EIITNRILKATDLDSDDKSLSFVLHSGPQQGL 1354
VV + H + GL++ +G + I+ + T+ D S+ F + Q G
Sbjct: 654 LKVVAIRPAIQIHRST--GLRLAQGSAMPILPANLSVETNAVGQDVSVLFRVTGALQFGE 711
Query: 1355 LQRLRKPRGEVRNNLTLGMNFTQDEINRGLICYIHTGQE----GIVDIIKFDVTDGVNTL 1410
LQ+ + G F Q ++ +G + Y+ T + V+ + +V G L
Sbjct: 712 LQK-QGAGGVEGAEWWATQAFHQRDVEQGRVRYLSTDPQHHAYDTVENLALEVQVGQEIL 770
Query: 1411 TDHYFYVTIGNLDSVFPEVISKRITLIEGARVTLTNNLLTNSDINSSDE-HHFSITRAPS 1469
++ F VTI + + +T + T + S H+ + +AP
Sbjct: 771 SNLSFPVTIQRATVWMLRLEPLHTQNTQQETLTTAHLEATLEEAGPSPPTFHYEVVQAPR 830
Query: 1470 LGHLESSDYAGEPIASFTQLQLASNKISYVHTSN-DEKKMDSFEFQVIGELY--PVFRTF 1526
G+L+ FTQ + + +++Y T+ E D+F F+V Y P++ TF
Sbjct: 831 KGNLQLQGTRLSDGQGFTQDDIQAGRVTYGATARASEAVEDTFRFRVTAPPYFSPLY-TF 889
Query: 1527 RIFITDVDNKKPILTIHRLTLQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHGKIL 1586
I I D P+LT L + + +++ L V+ ++ L+ + + P HG++
Sbjct: 890 PIHIGG-DPDAPVLTNVLLVVPEGGEGVLSADHLFVKSLNSAS--YLYEVMERPRHGRLA 946
Query: 1587 YNGSRP----VTTFTKQDLNKNLISYKHDGSETTEDSFSLTVTDGTHTDFYVLPDTALAT 1642
+ G++ VT+FT +DL + + Y+HD SETTED T + D A
Sbjct: 947 WRGTQDKTTMVTSFTNEDLLRGRLVYQHDDSETTEDDIPFVATRQGESS----GDMAWEE 1002
Query: 1643 HKPQVMRVQIRSLDNRLPQITTNRGAPALKRLHTGHMG-FLITSKSLKAEDQDSPHRLLK 1701
+ V RV I+ +++ P T +R H G L+T+ + D DS +
Sbjct: 1003 VR-GVFRVAIQPVNDHAPVQTISR------IFHVARGGRRLLTTDDVAFSDADSGFADAQ 1055
Query: 1702 YKVTRGP-EHGFIIKTGLGNQSTRVFTQADIDEMKISYV 1739
+TR G I+ + FTQ D+ + ++ +V
Sbjct: 1056 LVLTRKDLLFGSIVAVDEPTRPIYRFTQEDLRKRRVLFV 1094
Score = 97.4 bits (241), Expect = 1e-19
Identities = 275/1342 (20%), Positives = 484/1342 (36%), Gaps = 205/1342 (15%)
Query: 325 LTPDALAAEDVESDPGDLVFNILNAPTHPPGHPGQQGYVVSTDDPLGLPVSFFTQQELRE 384
L+ D L + + S ++ ++ P H G +G T D + V+ FT ++L
Sbjct: 917 LSADHLFVKSLNS--ASYLYEVMERPRH--GRLAWRG----TQDKTTM-VTSFTNEDLLR 967
Query: 385 LKIAYQ-----------PPAENSHGERLFQLELEVVDGDGAASDPFAFMVTVKSMNTLVP 433
++ YQ P GE + E V G F V ++ +N P
Sbjct: 968 GRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRG--------VFRVAIQPVNDHAP 1019
Query: 434 VASHNRGLVLFEGQSRPLSSTHSIPISDKDN-LEEVKMAAVR-GLRHGQLVVFGAPAGCK 491
V + +R + G R L +T + SD D+ + ++ R L G +V P
Sbjct: 1020 VQTISRIFHVARG-GRRLLTTDDVAFSDADSGFADAQLVLTRKDLLFGSIVAVDEPTRPI 1078
Query: 492 Y-FTPADLAAGRVVYQHDGSNTYSDNIIFRMEDGHHQVDFLFPLTILPVDDEPPMVNTNT 550
Y FT DL RV++ H G++ I ++ DG HQ L L V P +
Sbjct: 1079 YRFTQEDLRKRRVLFVHSGADR--GWIQLQVSDGQHQATAL-----LEVQASEPYLRVAN 1131
Query: 551 GLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQPLKGNEEEPQWELAPGSSHSGHYL 610
G SL Q Q + D+ + + N ++ +E HY
Sbjct: 1132 GSSLVVPQGGQ-----------GTIDTAVLHLDTNLDIRSGDEV-------------HYH 1167
Query: 611 GDLLLQQAELPLSTEDEDWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHLGPHSPQSVMV 670
T W + + G + T + Q+D+++G + Y H G SP+ M
Sbjct: 1168 ------------VTAGPRWGQLVRAG---QPATAFSQQDLLDGAVLYSHNGSLSPRDTM- 1211
Query: 671 QLAFHVQDD--HDPPNLSKQHIFTIKVQPVDILSPQLYPGTTLEMTVQEYQLTHFQKNFL 728
AF V+ H L + P+ ++ + ++ V + + +++ L
Sbjct: 1212 --AFSVEAGPVHTDATLQVTIALEGPLAPLKLVRHK-------KIYVFQGEAAEIRRDQL 1262
Query: 729 RYIDQDSDDQNLWYTLLTLPTDTDGNHQVRAGEIVLTDSPDTL--IMHFTQAQVNQHKVA 786
+ ++ +++ + P+ + V L D P +L + F+Q V+ +V
Sbjct: 1263 EAAQEAVPPADIVFSVKSPPS---AGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVL 1319
Query: 787 YQPPQKLGIAPRVVQFTYQVEDAAGNSVPGTFTLFLQPVDNQPPEVTNRGFAILEGGSFN 846
Y L P + ++ A+G P L V + + F++ EGGS
Sbjct: 1320 Y-----LHSRPEAWSDAFSLDVASGLGAPLEGVLVELEVLPAAIPLEAQNFSVPEGGSLT 1374
Query: 847 LSSNELHVTDP-DTDIDQIVFILVRGPQHGHLQYFKRCMVPG-ESFMQADVINGSVSYQH 904
L+ L V+ P + + ++ PQHG LQ +F V + Y H
Sbjct: 1375 LAPPLLRVSGPYFPTLLGLSLQVLEPPQHGALQKEDGPQARTLSAFSWRMVEEQLIRYVH 1434
Query: 905 GRDQTTTSDTFHLEVS----DGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVL 960
+T T D+F L + D H P+ ++V P N P I ++ L +
Sbjct: 1435 DGSETLT-DSFVLMANASEMDRQSH-PVAFTVTVLP--VNDQPPILTTNTGL-----QMW 1485
Query: 961 ENKATEITMGVIHGKRKDVGDLMLSFIVKDSPKLGTILVNGLP---TERFTQEDLINGRV 1017
E I + D G L + + + P G +++ G P FTQ L G V
Sbjct: 1486 EGATAPIPAEALRSTDGDSGSEDLVYTI-EQPSNGRVVLRGAPGTEVRSFTQAQLDGGLV 1544
Query: 1018 AYAHTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVLVGES 1077
++H G F LS D G+ Q QV + + ++
Sbjct: 1545 LFSHRGTLDG------GFRFRLS-DGEHTSPGHFFRVTAQKQVLL--------SLKGSQT 1589
Query: 1078 FIVYEGEKNSLTLQHLHV-EDVDTHQDELLCTVTSQPASGYLEKIASAPGSKMSQSGSPI 1136
V G L+ Q L T LL V P G L ++ +G +
Sbjct: 1590 LTVCPGSVQPLSSQTLRASSSAGTDPQLLLYRVVRGPQLGRLFH------AQQDSTGEAL 1643
Query: 1137 SAFSLRDIQVRHINYVQSIHKGVEPQEDQFTFYCSDGINFSP----NVFFPIIILPTNDE 1192
F+ ++ +I Y + P E + + + + S +V + + + +
Sbjct: 1644 VNFTQAEVYAGNILYEHEM-----PPEPFWEAHDTLELQLSSPPARDVAATLAVAVSFEA 1698
Query: 1193 Q-PKLFAHEFK-----VLEGMSLVIDTQLLNGAD--ADLP-----PNELHFQLTALPRHG 1239
P+ +H +K V EG I L+ ++ A +P +++ FQ+T P G
Sbjct: 1699 ACPQRPSHLWKNKGLWVPEGQRARITVAALDASNLLASVPSPQRSEHDVLFQVTQFPSRG 1758
Query: 1240 RIIQQLATGSQPIHS---FTLKEIQEASTIVYEHDDSETKEDSFE--------VWLSDGK 1288
QL +P+H+ L+ A +VY H T++D F S
Sbjct: 1759 ----QLLVSEEPLHAGQPHFLQSQLAAGQLVYAHGGGGTQQDGFHFRAHLQGPAGASVAG 1814
Query: 1289 HTTHRKVPIVVTLVDDETPHLTVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHS 1348
T I V V++ P + L++ +G I+ L D DS + + +
Sbjct: 1815 PQTSEAFAITVRDVNERPPQPQASVPLRLTRGSRAPISRAQLSVVDPDSAPGEIEYEVQR 1874
Query: 1349 GPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEINRGLICYIHTGQEGIVDIIKFDVTDGVN 1408
P G L + G V FTQ +++ G + ++ G + I + ++DG +
Sbjct: 1875 APHNGFLSLVGGGLGPV-------TRFTQADVDSGRLAFVANG-SSVAGIFQLSMSDGAS 1926
Query: 1409 TLTDHYFYVTIGNLDSVFPEVISKRITLIEG-ARVTLTNNLLTNSDINSSDEHHFSITRA 1467
V I L S + + + + R +L+ L E + + +
Sbjct: 1927 PPLPMSLAVDI--LPSAIEVQLRAPLEVPQALGRSSLSQQQLRVVSDREEPEAAYRLIQG 1984
Query: 1468 PSLGHLESSDYAGEPIASFTQLQLASNKISYVHTSNDEKKMDSFEFQVIGELYPVFRTFR 1527
P GHL G P ++F+Q Q+ ++ + T N D F +
Sbjct: 1985 PQYGHLL---VGGRPTSAFSQFQIDQGEVVFAFT-NFSSSHDHFRVLALARGVNASAVVN 2040
Query: 1528 IFITDVDNKKPILTIHRLTLQKEDSQLITLLELTVEDSDTPDDLILFTITQVPMHGKILY 1587
+ + + + + + D ++ EL P F + + P HG+++
Sbjct: 2041 VTVRALLHVWAGGPWPQGATLRLDPTVLDAGELANRTGSVP----RFRLLEGPRHGRVVR 2096
Query: 1588 --------NGSRPVTTFTKQDL 1601
GS+ V FT+QDL
Sbjct: 2097 VPRARTEPGGSQLVEQFTQQDL 2118
Score = 90.9 bits (224), Expect = 1e-17
Identities = 242/1106 (21%), Positives = 411/1106 (37%), Gaps = 221/1106 (19%)
Query: 221 PKYGRLVDAVGAPLPRGKGVDCEAFLRAGVRYQHTATSSPNRDYVPMMVELLGPEGQDAG 280
P++G+LV A G P D L V Y H + SP RD + VE GP DA
Sbjct: 1172 PRWGQLVRA-GQPATAFSQQD---LLDGAVLYSHNGSLSP-RDTMAFSVEA-GPVHTDAT 1225
Query: 281 SAGVLVREHFQLLVRIRGGAENTPPRP-SFMATMMMEVDPLVLTALTPDALAAEDVESDP 339
Q+ + + G P P + + V + D L A P
Sbjct: 1226 ---------LQVTIALEG-----PLAPLKLVRHKKIYVFQGEAAEIRRDQLEAAQEAVPP 1271
Query: 340 GDLVFNILNAPTHPPGHPGQQGYVVST------DDPLGL-PVSFFTQQELRELKIAYQPP 392
D+VF++ + P+ GY+V D+P L PV F+Q+ + ++ Y
Sbjct: 1272 ADIVFSVKSPPS--------AGYLVMVSRGALADEPPSLDPVQSFSQEAVDTGRVLYLHS 1323
Query: 393 AENSHGERLFQLELEVVDGDGAASDPFAFMVTVKSMNTLVPVASHNRGLVLFEGQSRPLS 452
+ + L+V G GA + +V ++ + +P+ + N + EG S L+
Sbjct: 1324 RPEAWSDAF---SLDVASGLGAPLE--GVLVELEVLPAAIPLEAQNFSVP--EGGSLTLA 1376
Query: 453 STHSIPISDK--DNLEEVKMAAVRGLRHGQLVVFGAPAG--CKYFTPADLAAGRVVYQHD 508
+ +S L + + + +HG L P F+ + + Y HD
Sbjct: 1377 PP-LLRVSGPYFPTLLGLSLQVLEPPQHGALQKEDGPQARTLSAFSWRMVEEQLIRYVHD 1435
Query: 509 GSNTYSDNIIF-----RMEDGHHQVDFLFPLTILPVDDEPPMVNTNTGLSLTEGQVVQIS 563
GS T +D+ + M+ H V F +T+LPV+D+PP++ TNTGL + EG I
Sbjct: 1436 GSETLTDSFVLMANASEMDRQSHPV--AFTVTVLPVNDQPPILTTNTGLQMWEGATAPIP 1493
Query: 564 PFVLSATDIDSEDSTIHFVLENQPLKGNEEEPQWELAPGSSHSGHYLGDLLLQQAELPLS 623
L +TD DS + + +E QP G APG+
Sbjct: 1494 AEALRSTDGDSGSEDLVYTIE-QPSNG---RVVLRGAPGTE------------------- 1530
Query: 624 TEDEDWHYMEKEGLYEKVVTEWLQRDIMEGRLFYRHLGPHSPQSVMVQLAFHVQD-DHDP 682
V + Q + G + + H G ++ F + D +H
Sbjct: 1531 ------------------VRSFTQAQLDGGLVLFSHRG-----TLDGGFRFRLSDGEHTS 1567
Query: 683 PNLSKQHIFTIKVQPVDILSPQ------LYPGTTLEMTVQEYQLTHFQKNFLRYIDQDSD 736
P H F + Q +LS + + PG+ ++ Q + + +D
Sbjct: 1568 PG----HFFRVTAQKQVLLSLKGSQTLTVCPGSVQPLSSQTLRASS---------SAGTD 1614
Query: 737 DQNLWYTLLTLPTDTDGNHQVRAGEIVLTDSPDTLIMHFTQAQVNQHKVAYQ---PPQKL 793
Q L Y ++ P Q+ DS +++FTQA+V + Y+ PP+
Sbjct: 1615 PQLLLYRVVRGP-------QLGRLFHAQQDSTGEALVNFTQAEVYAGNILYEHEMPPEPF 1667
Query: 794 GIAPRVVQFTYQVEDAAGNSVPGTFTL---FLQPVDNQPPEV-TNRGFAILEG------- 842
A ++ Q+ V T + F +P + N+G + EG
Sbjct: 1668 WEAHDTLEL--QLSSPPARDVAATLAVAVSFEAACPQRPSHLWKNKGLWVPEGQRARITV 1725
Query: 843 GSFNLSSNELHVTDPDTDIDQIVFILVRGPQHGHLQYFKRCMVPGE-SFMQADVINGSVS 901
+ + S+ V P ++F + + P G L + + G+ F+Q+ + G +
Sbjct: 1726 AALDASNLLASVPSPQRSEHDVLFQVTQFPSRGQLLVSEEPLHAGQPHFLQSQLAAGQLV 1785
Query: 902 YQHGRDQTTTSDTFHLEVSDGVHHIPITIPISVHPNVANRSPRISLRSSSLLDVSIDVLE 961
Y HG T D FH H+ SV + + I++R DV+ +
Sbjct: 1786 YAHG-GGGTQQDGFHFRA-----HLQGPAGASVAGPQTSEAFAITVR-----DVNERPPQ 1834
Query: 962 NKATEITMGVIHGKRKDVGDLMLSFIVKDS------------PKLG--TILVNGL-PTER 1006
+A+ + + + G R + LS + DS P G +++ GL P R
Sbjct: 1835 PQAS-VPLRLTRGSRAPISRAQLSVVDPDSAPGEIEYEVQRAPHNGFLSLVGGGLGPVTR 1893
Query: 1007 FTQEDLINGRVAYAHTAGEVGFQKQHDAFSLILSKDSYQWVVGNSIIEKVQVQVTVLPVD 1066
FTQ D+ +GR+A+ V F L +S G S + + V +LP
Sbjct: 1894 FTQADVDSGRLAFVANGSSVA-----GIFQLSMSD-------GASPPLPMSLAVDILP-- 1939
Query: 1067 NVGPKVLVGESFIVYEGEKNSLTLQHLHVEDVDTHQDELLCTVTSQPASGYLEKIASAPG 1126
+ L + ++SL+ Q L V D + E + P G+L
Sbjct: 1940 SAIEVQLRAPLEVPQALGRSSLSQQQLRVVS-DREEPEAAYRLIQGPQYGHL-------- 1990
Query: 1127 SKMSQSGSPISAFSLRDIQVRHINYVQSIHKGVEPQEDQF-TFYCSDGINFSPNVFFPII 1185
G P SAFS I + + D F + G+N S V +
Sbjct: 1991 ---LVGGRPTSAFSQFQIDQGEVVFA---FTNFSSSHDHFRVLALARGVNASAVVNVTV- 2043
Query: 1186 ILPTNDEQPKLFAHEF---KVLEGMSLVIDTQLLNGAD-ADLPPNELHFQLTALPRHGRI 1241
+ H + +G +L +D +L+ + A+ + F+L PRHGR+
Sbjct: 2044 ---------RALLHVWAGGPWPQGATLRLDPTVLDAGELANRTGSVPRFRLLEGPRHGRV 2094
Query: 1242 IQQLAT-----GSQPIHSFTLKEIQE 1262
++ GSQ + FT +++++
Sbjct: 2095 VRVPRARTEPGGSQLVEQFTQQDLED 2120
Score = 90.1 bits (222), Expect = 2e-17
Identities = 202/865 (23%), Positives = 324/865 (37%), Gaps = 109/865 (12%)
Query: 814 VPGTFTLFLQPVDNQPPEVTNRGFAILEGGSFNLSSNELHVTDPDTDIDQIVFILVRGPQ 873
+P F F Q + P V G A LE + L + + + Q++F + RG +
Sbjct: 421 LPPVFANFTQLLTISPLVVAEGGTAWLE---WRHVQPTLDLMEAELRKSQVLFSVTRGAR 477
Query: 874 HGHLQYFKRCMVPGESFMQADVINGSVSYQHGRDQTTTSDTFHLEVSDGVHHIPI----- 928
HG L+ + F DV+N + H + TSD LEVS +P+
Sbjct: 478 HGELELDIPGAQARKMFTLLDVVNRKARFIHDGSE-DTSDQLVLEVS-VTARVPMPSCLR 535
Query: 929 -----TIPISVHPNVANRSPRISLRSSSLLDVSIDVLENKATEITMGVIHGKRKDVGDLM 983
+PI V+P N P I SL+ +LE+ + V D
Sbjct: 536 RGQTYLLPIQVNP--VNDPPHIIFPHGSLM----VILEHTQKPLGPEVFQAYDPDSACEG 589
Query: 984 LSFIVKDSPKLGTILVNGLPTER----------FTQEDLINGRVAYAHTAGEVGFQKQHD 1033
L+F V LGT +GLP ER F+ +L G + Y H G Q
Sbjct: 590 LTFQV-----LGT--SSGLPVERRDQPGEPATEFSCRELEAGSLVYVHRGGPA----QDL 638
Query: 1034 AFSLILSKDSYQWVVGNSIIEKVQVQVTVLPVDNVGPKVLVGES--FIVYEGEKNSLTLQ 1091
F + D Q L V + P + + S + +G +
Sbjct: 639 TFRV---SDGLQ-----------ASPPATLKVVAIRPAIQIHRSTGLRLAQGSAMPILPA 684
Query: 1092 HLHVEDVDTHQD-ELLCTVTSQPASGYLEKIASAPGSKMSQSGSPISAFSLRDIQVRHIN 1150
+L VE QD +L VT G L+K G AF RD++ +
Sbjct: 685 NLSVETNAVGQDVSVLFRVTGALQFGELQK--QGAGGVEGAEWWATQAFHQRDVEQGRVR 742
Query: 1151 YVQSIHKGVEPQE------DQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEFKVL 1204
Y+ + +PQ + G N+ FP+ I +L +
Sbjct: 743 YLST-----DPQHHAYDTVENLALEVQVGQEILSNLSFPVTIQRATVWMLRLEPLHTQNT 797
Query: 1205 EGMSLVIDTQLLNGADADLPPNELHFQLTALPRHGRIIQQLATGSQPIHSFTLKEIQEAS 1264
+ +L +A P H+++ PR G +Q T FT +IQ A
Sbjct: 798 QQETLTTAHLEATLEEAGPSPPTFHYEVVQAPRKGN-LQLQGTRLSDGQGFTQDDIQ-AG 855
Query: 1265 TIVY--EHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPHLTVNNGLKVEKGHS 1322
+ Y SE ED+F ++ + + + D + P LT N L V +G
Sbjct: 856 RVTYGATARASEAVEDTFRFRVTAPPYFSPLYTFPIHIGGDPDAPVLT-NVLLVVPEGGE 914
Query: 1323 EIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNLTLGMNFTQDEINR 1382
+++ L L+S S + + P+ G L RG ++ T+ +FT +++ R
Sbjct: 915 GVLSADHLFVKSLNS--ASYLYEVMERPRHGRLAW----RG-TQDKTTMVTSFTNEDLLR 967
Query: 1383 GLICYIHTGQEGIVDIIKFDVTDGVNTLTD-------HYFYVTIGNLDSVFP-EVISKRI 1434
G + Y H E D I F T + D F V I ++ P + IS+
Sbjct: 968 GRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRGVFRVAIQPVNDHAPVQTISRIF 1027
Query: 1435 TLIEGARVTLTNNLLTNSDINSS-DEHHFSITRAPSL-GHLESSDYAGEPIASFTQLQLA 1492
+ G R LT + + SD +S + +TR L G + + D PI FTQ L
Sbjct: 1028 HVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKDLLFGSIVAVDEPTRPIYRFTQEDLR 1087
Query: 1493 SNKISYVHTSNDEKKMDSFEFQVIGELYPVFRTFRIFITDVDNKKPILTI---HRLTLQK 1549
++ +VH+ D + QV + + +V +P L + L + +
Sbjct: 1088 KRRVLFVHSGADR---GWIQLQVSDGQHQA-----TALLEVQASEPYLRVANGSSLVVPQ 1139
Query: 1550 EDSQLI--TLLELTVEDSDTPDDLILFTITQVPMHGKILYNGSRPVTTFTKQDLNKNLIS 1607
I +L L D + + +T P G+++ G +P T F++QDL +
Sbjct: 1140 GGQGTIDTAVLHLDTNLDIRSGDEVHYHVTAGPRWGQLVRAG-QPATAFSQQDLLDGAVL 1198
Query: 1608 YKHDGSETTEDSFSLTVTDG-THTD 1631
Y H+GS + D+ + +V G HTD
Sbjct: 1199 YSHNGSLSPRDTMAFSVEAGPVHTD 1223
Score = 43.9 bits (102), Expect = 0.002
Identities = 43/150 (28%), Positives = 64/150 (42%), Gaps = 17/150 (11%)
Query: 441 LVLFEGQSRPLSSTHSIPISDKDNLE----EVKMAAVRGLRHGQLV--VFGAPAGCKYFT 494
LV+ EG + L H P D E +V + RG RHG+L + GA A K FT
Sbjct: 437 LVVAEGGTAWLEWRHVQPTLDLMEAELRKSQVLFSVTRGARHGELELDIPGAQAR-KMFT 495
Query: 495 PADLAAGRVVYQHDGSNTYSDNIIFRMEDG---------HHQVDFLFPLTILPVDDEPPM 545
D+ + + HDGS SD ++ + +L P+ + PV+D P +
Sbjct: 496 LLDVVNRKARFIHDGSEDTSDQLVLEVSVTARVPMPSCLRRGQTYLLPIQVNPVNDPPHI 555
Query: 546 VNTNTGLS-LTEGQVVQISPFVLSATDIDS 574
+ + L + E + P V A D DS
Sbjct: 556 IFPHGSLMVILEHTQKPLGPEVFQAYDPDS 585
Score = 42.7 bits (99), Expect = 0.004
Identities = 61/237 (25%), Positives = 88/237 (37%), Gaps = 45/237 (18%)
Query: 377 FTQQELRELKIAYQPPAENSHGERLFQLELEVVDGDGAASDPFAFMVTVKS-MNTLVPVA 435
FTQ +++ ++ Y A S A D F F VT + L
Sbjct: 847 FTQDDIQAGRVTYGATARASE----------------AVEDTFRFRVTAPPYFSPLYTFP 890
Query: 436 SHNRG-----------LVLFEGQSRPLSSTHSI--PISDKDNLEEVKMAAVRGLRHGQLV 482
H G LV+ EG LS+ H ++ L EV + RHG+L
Sbjct: 891 IHIGGDPDAPVLTNVLLVVPEGGEGVLSADHLFVKSLNSASYLYEV----MERPRHGRLA 946
Query: 483 VFGAPAGCKY---FTPADLAAGRVVYQHDGSNTYSDNIIF-RMEDGHHQVDF-------L 531
G FT DL GR+VYQHD S T D+I F G D +
Sbjct: 947 WRGTQDKTTMVTSFTNEDLLRGRLVYQHDDSETTEDDIPFVATRQGESSGDMAWEEVRGV 1006
Query: 532 FPLTILPVDDEPPMVNTNTGLSLTEGQVVQISPFVLSATDIDSEDSTIHFVLENQPL 588
F + I PV+D P+ + + G ++ ++ +D DS + VL + L
Sbjct: 1007 FRVAIQPVNDHAPVQTISRIFHVARGGRRLLTTDDVAFSDADSGFADAQLVLTRKDL 1063
>gi|10863913 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform A [Homo sapiens]
Length = 973
Score = 75.1 bits (183), Expect = 7e-13
Identities = 68/232 (29%), Positives = 98/232 (42%), Gaps = 30/232 (12%)
Query: 1775 ICLEKEYYIVDEDSTFLEVTLTRRGY-LGETSFISIGTKDETAKKDKDFKWKTNKQIQFN 1833
I E+ Y E+ + +T+ RRG L T F+ T+D TA D+++ T + F
Sbjct: 409 IFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEF-TEGTVVFK 467
Query: 1834 PGQTTATWRVRIIPDNEYETSETFQIILSE------------------PLMAVLEFPEMA 1875
PG T RV II D+ +E E F + LS +A L P A
Sbjct: 468 PGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTA 527
Query: 1876 TVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISS 1935
TV I D E + E IG + + V R+ A +IV T +G+A G
Sbjct: 528 TVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGG--- 584
Query: 1936 TVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLP 1987
D+ ED L F +E KT V +IDD YE+ ++F + + P
Sbjct: 585 ---GEDF----EDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEP 629
Score = 58.5 bits (140), Expect = 7e-08
Identities = 66/258 (25%), Positives = 104/258 (40%), Gaps = 44/258 (17%)
Query: 1878 EIVDPGDESTVYIPEAEYKIEEDIGELLIPV-RRSGDASQELIVICSTRQGSATGTISST 1936
E+ + S ++ + Y+ E+ G + + + RR GD + + V T G+A
Sbjct: 399 EVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAG---- 454
Query: 1937 VLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESF-------SVSLRLPVG 1989
SDY E + F +TQK +V IIDD ++EE+E+F VS
Sbjct: 455 ---SDY----EFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASED 507
Query: 1990 GQLGARF---------PTTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDL 2040
G L A P+T + D + F + HV+ES +EV V R
Sbjct: 508 GILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTS--- 564
Query: 2041 SQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDD----------- 2089
++ V + E + G D+ L+F ++T V ++DD
Sbjct: 565 GARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFL 624
Query: 2090 -LGQPTL-EGPEKFELLL 2105
+G+P L E EK LLL
Sbjct: 625 EIGEPRLVEMSEKKALLL 642
>gi|163914369 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform B [Homo sapiens]
Length = 968
Score = 75.1 bits (183), Expect = 7e-13
Identities = 68/232 (29%), Positives = 98/232 (42%), Gaps = 30/232 (12%)
Query: 1775 ICLEKEYYIVDEDSTFLEVTLTRRGY-LGETSFISIGTKDETAKKDKDFKWKTNKQIQFN 1833
I E+ Y E+ + +T+ RRG L T F+ T+D TA D+++ T + F
Sbjct: 409 IFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEF-TEGTVVFK 467
Query: 1834 PGQTTATWRVRIIPDNEYETSETFQIILSE------------------PLMAVLEFPEMA 1875
PG T RV II D+ +E E F + LS +A L P A
Sbjct: 468 PGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTA 527
Query: 1876 TVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISS 1935
TV I D E + E IG + + V R+ A +IV T +G+A G
Sbjct: 528 TVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGG--- 584
Query: 1936 TVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLP 1987
D+ ED L F +E KT V +IDD YE+ ++F + + P
Sbjct: 585 ---GEDF----EDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFLEIGEP 629
Score = 59.7 bits (143), Expect = 3e-08
Identities = 69/270 (25%), Positives = 109/270 (40%), Gaps = 45/270 (16%)
Query: 1878 EIVDPGDESTVYIPEAEYKIEEDIGELLIPV-RRSGDASQELIVICSTRQGSATGTISST 1936
E+ + S ++ + Y+ E+ G + + + RR GD + + V T G+A
Sbjct: 399 EVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAG---- 454
Query: 1937 VLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESF-------SVSLRLPVG 1989
SDY E + F +TQK +V IIDD ++EE+E+F VS
Sbjct: 455 ---SDY----EFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASED 507
Query: 1990 GQLGARF---------PTTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDL 2040
G L A P+T + D + F + HV+ES +EV V R
Sbjct: 508 GILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTS--- 564
Query: 2041 SQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDD----------- 2089
++ V + E + G D+ L+F ++T V ++DD
Sbjct: 565 GARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKTISVKVIDDEEYEKNKTFFL 624
Query: 2090 -LGQPTL-EGPEKFELLLQMPMG-AVLGEP 2116
+G+P L E EK LLL G + G+P
Sbjct: 625 EIGEPRLVEMSEKKALLLNELGGFTITGQP 654
>gi|163914373 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform D [Homo sapiens]
Length = 937
Score = 74.3 bits (181), Expect = 1e-12
Identities = 78/274 (28%), Positives = 112/274 (40%), Gaps = 36/274 (13%)
Query: 1775 ICLEKEYYIVDEDSTFLEVTLTRRGY-LGETSFISIGTKDETAKKDKDFKWKTNKQIQFN 1833
I E+ Y E+ + +T+ RRG L T F+ T+D TA D+++ T + F
Sbjct: 409 IFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEF-TEGTVVFK 467
Query: 1834 PGQTTATWRVRIIPDNEYETSETFQIILSE------------------PLMAVLEFPEMA 1875
PG T RV II D+ +E E F + LS +A L P A
Sbjct: 468 PGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTA 527
Query: 1876 TVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISS 1935
TV I D E + E IG + + V R+ A +IV T +G+A G
Sbjct: 528 TVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGG--- 584
Query: 1936 TVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLPVGGQLGAR 1995
D+ ED L F +E K + I D YE+E SFS+ L P + G +
Sbjct: 585 ---GEDF----EDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVLEEPKWIRRGMK 637
Query: 1996 FPTTKVTILADRYD--EPVLHFGDAEYHVNESAR 2027
T + D YD +P+ + E + E R
Sbjct: 638 GGFT----ITDEYDDKQPLTSKEEEERRIAEMGR 667
Score = 52.8 bits (125), Expect = 4e-06
Identities = 60/248 (24%), Positives = 98/248 (39%), Gaps = 34/248 (13%)
Query: 1878 EIVDPGDESTVYIPEAEYKIEEDIGELLIPV-RRSGDASQELIVICSTRQGSATGTISST 1936
E+ + S ++ + Y+ E+ G + + + RR GD + + V T G+A
Sbjct: 399 EVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAG---- 454
Query: 1937 VLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESF-------SVSLRLPVG 1989
SDY E + F +TQK +V IIDD ++EE+E+F VS
Sbjct: 455 ---SDY----EFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASED 507
Query: 1990 GQLGARF---------PTTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDL 2040
G L A P+T + D + F + HV+ES +EV V R
Sbjct: 508 GILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTS--- 564
Query: 2041 SQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEK 2100
++ V + E + G D+ L+F ++ + I D + E
Sbjct: 565 GARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFD---REEYEKECS 621
Query: 2101 FELLLQMP 2108
F L+L+ P
Sbjct: 622 FSLVLEEP 629
>gi|163914371 solute carrier family 8 (sodium/calcium exchanger),
member 1 isoform C [Homo sapiens]
Length = 960
Score = 72.0 bits (175), Expect = 6e-12
Identities = 69/232 (29%), Positives = 96/232 (41%), Gaps = 30/232 (12%)
Query: 1775 ICLEKEYYIVDEDSTFLEVTLTRRGY-LGETSFISIGTKDETAKKDKDFKWKTNKQIQFN 1833
I E+ Y E+ + +T+ RRG L T F+ T+D TA D+++ T + F
Sbjct: 409 IFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAGSDYEF-TEGTVVFK 467
Query: 1834 PGQTTATWRVRIIPDNEYETSETFQIILSE------------------PLMAVLEFPEMA 1875
PG T RV II D+ +E E F + LS +A L P A
Sbjct: 468 PGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASEDGILEANHVSTLACLGSPSTA 527
Query: 1876 TVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISS 1935
TV I D E + E IG + + V R+ A +IV T +G+A G
Sbjct: 528 TVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTSGARGNVIVPYKTIEGTARGG--- 584
Query: 1936 TVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLP 1987
D+ ED L F +E K + I D YE+E SFS+ L P
Sbjct: 585 ---GEDF----EDTCGELEFQNDEIVKIITIRIFDREEYEKECSFSLVLEEP 629
Score = 52.8 bits (125), Expect = 4e-06
Identities = 60/248 (24%), Positives = 98/248 (39%), Gaps = 34/248 (13%)
Query: 1878 EIVDPGDESTVYIPEAEYKIEEDIGELLIPV-RRSGDASQELIVICSTRQGSATGTISST 1936
E+ + S ++ + Y+ E+ G + + + RR GD + + V T G+A
Sbjct: 399 EVTENDPVSKIFFEQGTYQCLENCGTVALTIIRRGGDLTNTVFVDFRTEDGTANAG---- 454
Query: 1937 VLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESF-------SVSLRLPVG 1989
SDY E + F +TQK +V IIDD ++EE+E+F VS
Sbjct: 455 ---SDY----EFTEGTVVFKPGDTQKEIRVGIIDDDIFEEDENFLVHLSNVKVSSEASED 507
Query: 1990 GQLGARF---------PTTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDL 2040
G L A P+T + D + F + HV+ES +EV V R
Sbjct: 508 GILEANHVSTLACLGSPSTATVTIFDDDHAGIFTFEEPVTHVSESIGIMEVKVLRTS--- 564
Query: 2041 SQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEK 2100
++ V + E + G D+ L+F ++ + I D + E
Sbjct: 565 GARGNVIVPYKTIEGTARGGGEDFEDTCGELEFQNDEIVKIITIRIFD---REEYEKECS 621
Query: 2101 FELLLQMP 2108
F L+L+ P
Sbjct: 622 FSLVLEEP 629
>gi|17865805 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform B precursor [Homo sapiens]
Length = 924
Score = 70.5 bits (171), Expect = 2e-11
Identities = 64/229 (27%), Positives = 105/229 (45%), Gaps = 34/229 (14%)
Query: 1781 YYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTAT 1840
Y ++ L + + G + +T ++ T+D +A D+++ T + PG+T
Sbjct: 405 YQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEF-TEGTVVLKPGETQKE 463
Query: 1841 WRVRIIPDNEYETSETFQIILSE--------------------PL-MAVLEFPEMATVEI 1879
+ V II D+ +E E F + LS PL AVL P +ATV I
Sbjct: 464 FSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI 523
Query: 1880 VDPGDESTVYIPEAE-YKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVL 1938
+D D + ++ E + + E IG + + V R+ A +IV T +G+A G
Sbjct: 524 LDD-DHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGG------ 576
Query: 1939 FSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLP 1987
D+ ED L F +ET KT +V I+D+ YE +E+F ++L P
Sbjct: 577 GEDF----EDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEP 621
Score = 36.6 bits (83), Expect = 0.27
Identities = 24/75 (32%), Positives = 34/75 (45%), Gaps = 3/75 (4%)
Query: 2015 FGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFA 2074
F Y E+ V + V R+G D+S+ + K+E SA AG DY +
Sbjct: 400 FDPCSYQCLENCGAVLLTVVRKGGDMSKTMYV---DYKTEDGSANAGADYEFTEGTVVLK 456
Query: 2075 PGVRMQTFQVTILDD 2089
PG + F V I+DD
Sbjct: 457 PGETQKEFSVGIIDD 471
>gi|33946304 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform D precursor [Homo sapiens]
Length = 921
Score = 70.5 bits (171), Expect = 2e-11
Identities = 64/229 (27%), Positives = 105/229 (45%), Gaps = 34/229 (14%)
Query: 1781 YYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTAT 1840
Y ++ L + + G + +T ++ T+D +A D+++ T + PG+T
Sbjct: 405 YQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEF-TEGTVVLKPGETQKE 463
Query: 1841 WRVRIIPDNEYETSETFQIILSE--------------------PL-MAVLEFPEMATVEI 1879
+ V II D+ +E E F + LS PL AVL P +ATV I
Sbjct: 464 FSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI 523
Query: 1880 VDPGDESTVYIPEAE-YKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVL 1938
+D D + ++ E + + E IG + + V R+ A +IV T +G+A G
Sbjct: 524 LDD-DHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGG------ 576
Query: 1939 FSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLP 1987
D+ ED L F +ET KT +V I+D+ YE +E+F ++L P
Sbjct: 577 GEDF----EDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEP 621
Score = 36.6 bits (83), Expect = 0.27
Identities = 24/75 (32%), Positives = 34/75 (45%), Gaps = 3/75 (4%)
Query: 2015 FGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFA 2074
F Y E+ V + V R+G D+S+ + K+E SA AG DY +
Sbjct: 400 FDPCSYQCLENCGAVLLTVVRKGGDMSKTMYV---DYKTEDGSANAGADYEFTEGTVVLK 456
Query: 2075 PGVRMQTFQVTILDD 2089
PG + F V I+DD
Sbjct: 457 PGETQKEFSVGIIDD 471
>gi|33946311 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform C precursor [Homo sapiens]
Length = 927
Score = 70.5 bits (171), Expect = 2e-11
Identities = 64/229 (27%), Positives = 105/229 (45%), Gaps = 34/229 (14%)
Query: 1781 YYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTAT 1840
Y ++ L + + G + +T ++ T+D +A D+++ T + PG+T
Sbjct: 405 YQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEF-TEGTVVLKPGETQKE 463
Query: 1841 WRVRIIPDNEYETSETFQIILSE--------------------PL-MAVLEFPEMATVEI 1879
+ V II D+ +E E F + LS PL AVL P +ATV I
Sbjct: 464 FSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI 523
Query: 1880 VDPGDESTVYIPEAE-YKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVL 1938
+D D + ++ E + + E IG + + V R+ A +IV T +G+A G
Sbjct: 524 LDD-DHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGG------ 576
Query: 1939 FSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLP 1987
D+ ED L F +ET KT +V I+D+ YE +E+F ++L P
Sbjct: 577 GEDF----EDTYGELEFKNDETVKTIRVKIVDEEEYERQENFFIALGEP 621
Score = 36.6 bits (83), Expect = 0.27
Identities = 24/75 (32%), Positives = 34/75 (45%), Gaps = 3/75 (4%)
Query: 2015 FGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFA 2074
F Y E+ V + V R+G D+S+ + K+E SA AG DY +
Sbjct: 400 FDPCSYQCLENCGAVLLTVVRKGGDMSKTMYV---DYKTEDGSANAGADYEFTEGTVVLK 456
Query: 2075 PGVRMQTFQVTILDD 2089
PG + F V I+DD
Sbjct: 457 PGETQKEFSVGIIDD 471
>gi|15147254 solute carrier family 8 (sodium/calcium exchanger),
member 3 isoform A precursor [Homo sapiens]
Length = 925
Score = 67.8 bits (164), Expect = 1e-10
Identities = 61/229 (26%), Positives = 103/229 (44%), Gaps = 34/229 (14%)
Query: 1781 YYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTAT 1840
Y ++ L + + G + +T ++ T+D +A D+++ T + PG+T
Sbjct: 405 YQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANAGADYEF-TEGTVVLKPGETQKE 463
Query: 1841 WRVRIIPDNEYETSETFQIILSE--------------------PL-MAVLEFPEMATVEI 1879
+ V II D+ +E E F + LS PL AVL P +ATV I
Sbjct: 464 FSVGIIDDDIFEEDEHFFVRLSNVRIEEEQPEEGMPPAIFNSLPLPRAVLASPCVATVTI 523
Query: 1880 VDPGDESTVYIPEAE-YKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVL 1938
+D D + ++ E + + E IG + + V R+ A +IV T +G+A G
Sbjct: 524 LDD-DHAGIFTFECDTIHVSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGG------ 576
Query: 1939 FSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLP 1987
D+ ED L F +ET KT + +IDD YE+ +++ + + P
Sbjct: 577 GEDF----EDTYGELEFKNDETVKTIHIKVIDDEAYEKNKNYFIEMMGP 621
Score = 56.6 bits (135), Expect = 3e-07
Identities = 63/238 (26%), Positives = 94/238 (39%), Gaps = 37/238 (15%)
Query: 1874 MATVEIVDPGDE-STVYIPEAEYKIEEDIGELLIPV-RRSGDASQELIVICSTRQGSATG 1931
M+ V +P D S V+ Y+ E+ G +L+ V R+ GD S+ + V T GSA
Sbjct: 383 MSEVHTDEPEDFISKVFFDPCSYQCLENCGAVLLTVVRKGGDMSKTMYVDYKTEDGSANA 442
Query: 1932 TISSTVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLR------ 1985
+ +P ETQK V IIDD ++EE+E F V L
Sbjct: 443 GADYEFTEGTVVLKP-----------GETQKEFSVGIIDDDIFEEDEHFFVRLSNVRIEE 491
Query: 1986 --------------LPVGGQLGARFPTTKVTILADRYDEPVLHFGDAEYHVNESARYVEV 2031
LP+ + A VTIL D + + F HV+ES +EV
Sbjct: 492 EQPEEGMPPAIFNSLPLPRAVLASPCVATVTILDDDH-AGIFTFECDTIHVSESIGVMEV 550
Query: 2032 CVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDD 2089
V R ++ V R E + G D+ L+F ++T + ++DD
Sbjct: 551 KVLRTS---GARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHIKVIDD 605
Score = 35.0 bits (79), Expect = 0.79
Identities = 22/88 (25%), Positives = 39/88 (44%)
Query: 1784 VDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWRV 1843
V E +EV + R T + T + TAK + T +++F +T T +
Sbjct: 541 VSESIGVMEVKVLRTSGARGTVIVPFRTVEGTAKGGGEDFEDTYGELEFKNDETVKTIHI 600
Query: 1844 RIIPDNEYETSETFQIILSEPLMAVLEF 1871
++I D YE ++ + I + P M + F
Sbjct: 601 KVIDDEAYEKNKNYFIEMMGPRMVDMSF 628
>gi|57163987 solute carrier family 8 member 2 [Homo sapiens]
Length = 921
Score = 63.5 bits (153), Expect = 2e-09
Identities = 68/248 (27%), Positives = 107/248 (43%), Gaps = 38/248 (15%)
Query: 1756 EDNGGNKLTNQPFHLNWAWICLEKEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDET 1815
ED+G +++ +P + CLE + S L VT + G T ++ T+D +
Sbjct: 389 EDDGASRIFFEPS----LYHCLE------NCGSVLLSVTC-QGGEGNSTFYVDYRTEDGS 437
Query: 1816 AKKDKDFKWKTNKQIQFNPGQTTATWRVRIIPDNEYETSETFQIILS-----------EP 1864
AK D+++ + F PG+T R+ II D+ +E E F + L EP
Sbjct: 438 AKAGSDYEYSEGTLV-FKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEP 496
Query: 1865 -----LMAVLEFPEMATVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELI 1919
L P +ATV I+D + + E +G + + V RS A +
Sbjct: 497 DGGGRPKGRLVAPLLATVTILDDDHAGIFSFQDRLLHVSECMGTVDVRVVRSSGARGTVR 556
Query: 1920 VICSTRQGSATGTISSTVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEES 1979
+ T G+A G V + ED L F +ET KT QV I+DD YE++++
Sbjct: 557 LPYRTVDGTARG---GGVHY-------EDACGELEFGDDETMKTLQVKIVDDEEYEKKDN 606
Query: 1980 FSVSLRLP 1987
F + L P
Sbjct: 607 FFIELGQP 614
Score = 57.4 bits (137), Expect = 1e-07
Identities = 63/220 (28%), Positives = 89/220 (40%), Gaps = 31/220 (14%)
Query: 1886 STVYIPEAEYKIEEDIGELLIPVR-RSGDASQELIVICSTRQGSATGTISSTVLFSDYIS 1944
S ++ + Y E+ G +L+ V + G+ + V T GSA SDY
Sbjct: 394 SRIFFEPSLYHCLENCGSVLLSVTCQGGEGNSTFYVDYRTEDGSAKAG-------SDY-- 444
Query: 1945 RPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSL-RLPVGGQLGARFPT----- 1998
E L F ETQK ++ IIDD ++EE+E F V L L VG G P
Sbjct: 445 --EYSEGTLVFKPGETQKELRIGIIDDDIFEEDEHFFVRLLNLRVGDAQGMFEPDGGGRP 502
Query: 1999 ---------TKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDLSQPSSIAVR 2049
VTIL D + + F D HV+E V+V V R ++ +
Sbjct: 503 KGRLVAPLLATVTILDDDH-AGIFSFQDRLLHVSECMGTVDVRVVRSS---GARGTVRLP 558
Query: 2050 SRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDD 2089
R + + G Y L+F M+T QV I+DD
Sbjct: 559 YRTVDGTARGGGVHYEDACGELEFGDDETMKTLQVKIVDD 598
>gi|113722120 G protein-coupled receptor 98 precursor [Homo sapiens]
Length = 6306
Score = 58.5 bits (140), Expect = 7e-08
Identities = 78/319 (24%), Positives = 132/319 (41%), Gaps = 34/319 (10%)
Query: 1830 IQFNPGQTTATWRVRIIPDNEYETSETFQIILSEPLMAVLEFPEMATVEIVDPGDESTVY 1889
I F PG+ T + + ++ D E E F I L ++EI+ ++S V
Sbjct: 205 ITFPPGRATVIYNLTVLDDEVPENDEIFLIQLKSVEGGAEINTSRNSIEIIIKKNDSPVR 264
Query: 1890 IPEAEYKIEEDIGELLIPVRRSGDASQELI--------VICSTRQGSATGTISSTVLFSD 1941
++ Y + E+ L+IPV R D + LI + + G++T + F D
Sbjct: 265 FLQSIYLVPEEDHILIIPVVRGKDNNGNLIGSDEYEVSISYAVTTGNSTAHAQQNLDFID 324
Query: 1942 YISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLPV--GGQLGARFPTT 1999
+ +T+++ F + + I+DD++ E ESF + L G +
Sbjct: 325 L----QPNTTVV-FPPFIHESHLKFQIVDDTIPEIAESFHIMLLKDTLQGDAVLISPSVV 379
Query: 2000 KVTILADRYDEPVLHFGDAEYH----VNES--ARYVEVCVWRRGTDLSQPSSIAVRSRKS 2053
+VTI + VL F + ++E +RY E+ V R G S+ V +R S
Sbjct: 380 QVTIKPNDKPYGVLSFNSVLFERTVIIDEDRISRYEEITVVRNGGTHGNVSANWVLTRNS 439
Query: 2054 EQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEKFELLLQMPM---- 2109
S D S L FA G + T +T++DD + PE+ E L +
Sbjct: 440 TDPS-PVTADIRPSSGVLHFAQGQMLATIPLTVVDD------DLPEEAEAYLLQILPHTI 492
Query: 2110 --GAVLGEPNKTTIFIEDT 2126
GA + EP + +I+D+
Sbjct: 493 RGGAEVSEPAELLFYIQDS 511
Score = 51.6 bits (122), Expect = 8e-06
Identities = 72/307 (23%), Positives = 128/307 (41%), Gaps = 32/307 (10%)
Query: 1835 GQTTATWRVRIIPDNEYETSETFQIILSE---PLMAVLEFP-----EMATVEIV---DPG 1883
G+T A + I+ D+ E E F + L+ + A FP E T +++ + G
Sbjct: 2898 GETAAAINITILEDDVPELEEYFLVNLTYVGLTMAASTSFPPRLDSEGLTAQVIIDANDG 2957
Query: 1884 DESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVLFSDYI 1943
+ ++ +++ E G L + +RS + + + + A + DYI
Sbjct: 2958 ARGVIEWQQSRFEVNETHGSLTLVAQRSREPLGHVSLFVYAQNLEAQVGL-------DYI 3010
Query: 1944 SRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLPVGGQLGARFPTTKVTI 2003
P ILHF E K ++I+DD + E +E F + L P G + + +
Sbjct: 3011 FTP----MILHFADGERYKNVNIMILDDDIPEGDEKFQLILTNPSPGLELGKNTIALIIV 3066
Query: 2004 LADRYDEPVLHFGDAEYHV--NESARYVE--VCVWRRGTDLSQP--SSIAVRSRKSEQES 2057
LA+ VL F ++E+ +A YV+ V V + +Q ++ V+ +E S
Sbjct: 3067 LANDDGPGVLSFNNSEHFFLREPTALYVQESVAVLYIVREPAQGLFGTVTVQFIVTEVNS 3126
Query: 2058 AEAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEKFELLLQMPM-GAVLGEP 2116
+ D + GVR + Q++ + D +P ++ E F L P GA LG
Sbjct: 3127 SNESKDLTPSKGYIVLEEGVRFKALQISAILDT-EPEMD--EYFVCTLFNPTGGARLGVH 3183
Query: 2117 NKTTIFI 2123
+T I +
Sbjct: 3184 VQTLITV 3190
Score = 51.6 bits (122), Expect = 8e-06
Identities = 60/253 (23%), Positives = 101/253 (39%), Gaps = 28/253 (11%)
Query: 1734 MKISYVLNEGSNASKDIFYFSVEDNGGNKLTNQPFHLNWAWICLEKEYYIVDEDSTFLEV 1793
M+I+ ++ E ++ + IF F V G +T Y V L+V
Sbjct: 3896 MEIAEIMIEENDDPRGIFMFHVTRGAGEVITA----------------YEVPPPLNVLQV 3939
Query: 1794 TLTR-RGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWRVRIIPDNEYE 1852
+ R G G + + D +D FK ++ ++F Q TA + II D E+E
Sbjct: 3940 PVVRLAGSFGAVNVYWKASPDSAGLED--FK-PSHGILEFADKQVTAMIEITIIDDAEFE 3996
Query: 1853 TSETFQIILSEPLMAVLEFPEMATVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSG 1912
+ETF I L + + V +V P ++S P + EE ++I S
Sbjct: 3997 LTETFNISLIS-VAGGGRLGDDVVVTVVIPQNDS----PFGVFGFEEKT--VMIDESLSS 4049
Query: 1913 DASQELIVICSTRQGSATGTISSTVLFSDYISRP-EDHTSILHFDKNETQKTCQVLIIDD 1971
D + + R GT+ + LHFD+ E+QKT + + D
Sbjct: 4050 DDPDSYVTLTVVRSPGGKGTVRLEWTIDEKAKHNLSPLNGTLHFDETESQKTIVLHTLQD 4109
Query: 1972 SLYEEEESFSVSL 1984
++ EE+ F++ L
Sbjct: 4110 TVLEEDRRFTIQL 4122
Score = 49.3 bits (116), Expect = 4e-05
Identities = 63/223 (28%), Positives = 98/223 (43%), Gaps = 31/223 (13%)
Query: 1821 DFKWKTNKQIQFNPGQTTATWRVRIIPDNEYETSETFQIILSEP-LMAV---------LE 1870
D++ T + G A V I+PD+ E E+F I L E LM + +
Sbjct: 2502 DYEPVTRQWAIMQEGDEFANLTVSILPDDFPEMDESFLISLLEVHLMNISASLKNQPTIG 2561
Query: 1871 FPEMATVEIVDPGDESTVYIPEAEYKIEEDIGE--LLIPVRRSGDASQELIVICSTRQGS 1928
P ++TV I GD V++ Y I + E L + V+ + Q L+ + R G
Sbjct: 2562 QPNISTVVIALNGDAFGVFVI---YNISPNTSEDGLFVEVQ---EQPQTLVELMIHRTGG 2615
Query: 1929 ATGTIS--------STVLFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESF 1980
+ G ++ + D+I E IL F + ET+KT + I+DDS E++ES
Sbjct: 2616 SLGQVAVEWRVVGGTATEGLDFIGAGE----ILTFAEGETKKTVILTILDDSEPEDDESI 2671
Query: 1981 SVSLRLPVGG-QLGARFPTTKVTILADRYDEPVLHFGDAEYHV 2022
VSL GG ++ T +V ILA+ ++ F A V
Sbjct: 2672 IVSLVYTEGGSRILPSSDTVRVNILANDNVAGIVSFQTASRSV 2714
Score = 45.8 bits (107), Expect = 4e-04
Identities = 70/320 (21%), Positives = 124/320 (38%), Gaps = 30/320 (9%)
Query: 1826 TNKQIQFNPGQTTATWRVRIIPDNEYETSETFQIILSEPLMAVLEFPEMATVEIVDPGDE 1885
T+ I F GQT+A V I+PD + E + F + + L AT+ ++ D
Sbjct: 1916 TSGNITFEIGQTSANITVEILPDEDPELDKAFSVSVLSVSSGSLGAHINATLTVLASDDP 1975
Query: 1886 STVYI---PEAEYKIEEDIGELLIPVRRSGDASQELIVICST-----RQGSATGTISSTV 1937
++I K+EE + + + R +++V +T + ++
Sbjct: 1976 YGIFIFSEKNRPVKVEEATQNITLSIIRLKGLMGKVLVSYATLDDMEKPPYFPPNLARAT 2035
Query: 1938 LFSDYISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSL------------R 1985
DYI + F N+++ T + I+DD E ES + L
Sbjct: 2036 QGRDYIPA----SGFALFGANQSEATIAISILDDDEPERSESVFIELLNSTLVAKVQSRS 2091
Query: 1986 LPVGGQLGARFPT-TKVTILADRYDEPVLHFGDAEYHVNESARYVEVCVWRRGTDLSQPS 2044
+P +LG + T ++ I+A+ L V E+ + V R G + S
Sbjct: 2092 IPNSPRLGPKVETIAQLIIIANDDAFGTLQLSAPIVRVAENHVGPIINVTRTGGAFADVS 2151
Query: 2045 SIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEKFELL 2104
K+ +A AG DY S ++ G + + +++D+ P LE +L+
Sbjct: 2152 V----KFKAVPITAIAGEDYSIASSDVVLLEGETSKAVPIYVINDI-YPELEESFLVQLM 2206
Query: 2105 LQMPMGAVLGEPNKTTIFIE 2124
+ GA LG + I IE
Sbjct: 2207 NETTGGARLGALTEAVIIIE 2226
Score = 42.7 bits (99), Expect = 0.004
Identities = 40/139 (28%), Positives = 62/139 (44%), Gaps = 11/139 (7%)
Query: 1969 IDDSLYEEEESFSVSLR-LPVGGQLGARFPTTKVTILADRYDEPVLHFGDAEYHVNESAR 2027
++D + EE+ + L + GG L T +T++A F + V+E+ R
Sbjct: 4224 LNDDIPEEKSFYEFQLTAVSEGGVLSESSSTANITVVASDSPYGRFAFSHEQLRVSEAQR 4283
Query: 2028 YVEVCVWRRGTDLSQPSSIAVRS-RKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTI 2086
V + + R D VR K+ +AEAG D+V + L F G ++ V I
Sbjct: 4284 -VNITIIRSSGDFGH-----VRLWYKTMSGTAEAGLDFVPAAGELLFEAGEMRKSLHVEI 4337
Query: 2087 LDDLGQPTLEGPEKFELLL 2105
LDD EGPE+F L +
Sbjct: 4338 LDD---DYPEGPEEFSLTI 4353
Score = 40.0 bits (92), Expect = 0.025
Identities = 42/189 (22%), Positives = 81/189 (42%), Gaps = 19/189 (10%)
Query: 1807 ISIGTKDETAKKDKDF-KWKTNKQIQFNPGQTTATWRVRIIPDNEYETSETFQIILSEPL 1865
++ G A+++ DF + N + F P + + +I+ D E +E+F I+L +
Sbjct: 307 VTTGNSTAHAQQNLDFIDLQPNTTVVFPPFIHESHLKFQIVDDTIPEIAESFHIMLLKDT 366
Query: 1866 M---AVLEFPEMATVEIVDPGDESTVYIPEAEYKIEEDIGELLIPVRRSGDASQELIVIC 1922
+ AVL P + V I P D+ P + E + + + E I +
Sbjct: 367 LQGDAVLISPSVVQVTI-KPNDK-----PYGVLSFNSVLFERTVIIDEDRISRYEEITV- 419
Query: 1923 STRQGSATGTISSTVLFSDYISRPEDHTS-------ILHFDKNETQKTCQVLIIDDSLYE 1975
R G G +S+ + + + P T+ +LHF + + T + ++DD L E
Sbjct: 420 -VRNGGTHGNVSANWVLTRNSTDPSPVTADIRPSSGVLHFAQGQMLATIPLTVVDDDLPE 478
Query: 1976 EEESFSVSL 1984
E E++ + +
Sbjct: 479 EAEAYLLQI 487
Score = 39.3 bits (90), Expect = 0.042
Identities = 49/216 (22%), Positives = 85/216 (39%), Gaps = 35/216 (16%)
Query: 1811 TKDETAKKDKDFKWKTNKQIQFNPGQTTATWRVRIIPDNEYETSETFQIILS-------- 1862
T TA+ DF ++ F G+ + V I+ D+ E E F + ++
Sbjct: 4304 TMSGTAEAGLDFVPAAG-ELLFEAGEMRKSLHVEILDDDYPEGPEEFSLTITKVELQGRG 4362
Query: 1863 ------EPLMAVLEFPEMATVEIV-------DPGDESTVYIPE-AEYKIEEDIGELLIPV 1908
E + + + PE+ + IV D + + P+ +++EED+G ++IPV
Sbjct: 4363 YDFTIQENGLQIDQPPEIGNISIVRIIIMKNDNAEGIIEFDPKYTAFEVEEDVGLIMIPV 4422
Query: 1909 -RRSGDASQELIVICSTRQGSATGTISSTVLFSDYISRPEDHTSILHFDKNETQKTCQVL 1967
R G S ++ G + DYI H S + F + +
Sbjct: 4423 VRLHGTYGYVTADFISQSSSASPGGV-------DYIL----HGSTVTFQHGQNLSFINIS 4471
Query: 1968 IIDDSLYEEEESFSVSLRLPVGGQLGARFPTTKVTI 2003
IIDD+ E EE + L GG + R +++ I
Sbjct: 4472 IIDDNESEFEEPIEILLTGATGGAVLGRHLVSRIII 4507
Score = 38.9 bits (89), Expect = 0.055
Identities = 27/69 (39%), Positives = 40/69 (57%), Gaps = 5/69 (7%)
Query: 1942 YISRPEDH---TSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSLRLPVGG-QLGARFP 1997
YIS D + L F+ E + T V I+DD++ E+EESF V L+ P GG ++G
Sbjct: 3580 YISSHSDFIPSSGELIFEPGEREATIAVNILDDTVPEKEESFKVQLKNPKGGAEIGINDS 3639
Query: 1998 TTKVTILAD 2006
T +TIL++
Sbjct: 3640 VT-ITILSN 3647
Score = 37.7 bits (86), Expect = 0.12
Identities = 79/399 (19%), Positives = 150/399 (37%), Gaps = 36/399 (9%)
Query: 1731 IDEMKISYVLNEGSNASKDIFYFSVEDNGGNKLTNQPFHLNWAWICLEKEYYIVDEDSTF 1790
+D + + + + S+D+ +D GG F + A Y I + +S
Sbjct: 745 LDRVNVENQVLKSGYTSRDLIILENDDPGG------VFEFSPA---SRGPYVIKEGESVE 795
Query: 1791 LEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNPGQTTATWRVRIIPDNE 1850
L + +R + + + +D +F T ++F PG+ + D
Sbjct: 796 LHIIRSRGSLVKQFLHYRVEPRDSN-----EFYGNTGV-LEFKPGEREIVITLLARLDGI 849
Query: 1851 YETSETFQIILSEPLMAVLEFPEMATVEIVDPGDESTVYIPEAEYKIEEDIGE-LLIPVR 1909
E E + ++LS + V I T+ + + I E + + L++ +
Sbjct: 850 PELDEHYWVVLSSHGERESKLGSATIVNI-------TILKNDDPHGIIEFVSDGLIVMIN 902
Query: 1910 RS-GDASQELIVICSTRQGSATGTISSTVLFSDYISRPEDHTSILHFDKNETQKTCQVLI 1968
S GDA + +G+ S V+ D+ + F E K +
Sbjct: 903 ESKGDAIYSAVYDVVRNRGNFGDVSVSWVVSPDFTQDVFPVQGTVVFGDQEFSKNITIYS 962
Query: 1969 IDDSLYEEEESFSVSLRLPVGG-QLGARFPTTKVTILADRYDEPVLHFGDAEYHVNESAR 2027
+ D + EE E F+V L GG ++G R T T+ R D+P+ +F + +
Sbjct: 963 LPDEIPEEMEEFTVILLNGTGGAKVGNR---TTATLRIRRNDDPI-YFAEPRVVRVQEGE 1018
Query: 2028 YVEVCVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISR--NLDFAPGVRMQTFQVT 2085
V R G S + V+ + ++ D++ + + L F G R Q+ +
Sbjct: 1019 TANFTVLRNG---SVDVTCMVQYATKDGKATARERDFIPVEKGETLIFEVGSRQQSISIF 1075
Query: 2086 ILDDLGQPTLEGPEKFELLLQMPMGAVLGEPNKTTIFIE 2124
+ +D G P + P + +LL V+ + T+ IE
Sbjct: 1076 VNED-GIPETDEP-FYIILLNSTGDTVVYQYGVATVIIE 1112
Score = 34.7 bits (78), Expect = 1.0
Identities = 45/198 (22%), Positives = 79/198 (39%), Gaps = 36/198 (18%)
Query: 1843 VRIIPDNEYETSETFQIILSEPLMAVLEFP-----------EMATVEIVDPGDESTVYIP 1891
V I+PD+ E E F + ++E + +F E+A + I + D +++
Sbjct: 3856 VSILPDDLPELEEGFIVTITEVNLVNSDFSTGQPSVRRPGMEIAEIMIEENDDPRGIFMF 3915
Query: 1892 EAE---------YKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVLFSDY 1942
Y++ + L +PV R + + V SA D+
Sbjct: 3916 HVTRGAGEVITAYEVPPPLNVLQVPVVRLAGSFGAVNVYWKASPDSAG--------LEDF 3967
Query: 1943 ISRPEDHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSL-RLPVGGQLGARFPTTKV 2001
+ IL F + ++ IIDD+ +E E+F++SL + GG+LG V
Sbjct: 3968 ----KPSHGILEFADKQVTAMIEITIIDDAEFELTETFNISLISVAGGGRLG---DDVVV 4020
Query: 2002 TILADRYDEPVLHFGDAE 2019
T++ + D P FG E
Sbjct: 4021 TVVIPQNDSPFGVFGFEE 4038
Score = 32.7 bits (73), Expect = 3.9
Identities = 24/63 (38%), Positives = 32/63 (50%), Gaps = 4/63 (6%)
Query: 2062 TDYVGISRNLDFAPGVRMQTFQVTILDDLGQPTLEGPEKFELLLQMPM-GAVLGEPNKTT 2120
+D++ S L F PG R T V ILDD E E F++ L+ P GA +G + T
Sbjct: 3585 SDFIPSSGELIFEPGEREATIAVNILDD---TVPEKEESFKVQLKNPKGGAEIGINDSVT 3641
Query: 2121 IFI 2123
I I
Sbjct: 3642 ITI 3644
Score = 32.3 bits (72), Expect = 5.1
Identities = 23/61 (37%), Positives = 31/61 (50%), Gaps = 4/61 (6%)
Query: 2029 VEVCVWRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILD 2088
VE+ + R G L Q +AV R + E G D++G L FA G +T +TILD
Sbjct: 2606 VELMIHRTGGSLGQ---VAVEWRVVGGTATE-GLDFIGAGEILTFAEGETKKTVILTILD 2661
Query: 2089 D 2089
D
Sbjct: 2662 D 2662
Score = 31.6 bits (70), Expect = 8.7
Identities = 33/157 (21%), Positives = 65/157 (41%), Gaps = 11/157 (7%)
Query: 1829 QIQFNPGQTTATWRVRIIPDNEYETSETFQIILSEPL-MAVLEFPEMATVEIVDPGDEST 1887
++ F PG+ AT V I+ D E E+F++ L P A + + T+ I+ D++
Sbjct: 3593 ELIFEPGEREATIAVNILDDTVPEKEESFKVQLKNPKGGAEIGINDSVTITILS-NDDAY 3651
Query: 1888 VYIPEAEYKIEEDIGELLIPVRRSGDASQELIVICSTRQGSATGTISSTVLFSDYISRPE 1947
+ A+ + + + E+ L+ + R G I+ IS
Sbjct: 3652 GIVAFAQNSLYKQVEEM---------EQDSLVTLNVERLKGTYGRITIAWEADGSISDIF 3702
Query: 1948 DHTSILHFDKNETQKTCQVLIIDDSLYEEEESFSVSL 1984
+ ++ F + + T + I+ D++ E E V+L
Sbjct: 3703 PTSGVILFTEGQVLSTITLTILADNIPELSEVVIVTL 3739
>gi|54607027 integrin beta 4 isoform 2 precursor [Homo sapiens]
Length = 1805
Score = 45.4 bits (106), Expect = 6e-04
Identities = 42/156 (26%), Positives = 74/156 (47%), Gaps = 12/156 (7%)
Query: 1975 EEEESFSVSLRLPVG-GQLGARFPTTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCV 2033
+E++ ++ +P G LG R +TI+ ++ + V+ F E+ V+ + + V
Sbjct: 956 DEKQLLVEAIDVPAGTATLGRRL--VNITIIKEQARD-VVSFEQPEFSVSRGDQVARIPV 1012
Query: 2034 WRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILD-DLGQ 2092
RR D + S +++ +A+ DY+ + L F PG + QV +L+
Sbjct: 1013 IRRVLDGGKSQV----SYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVD 1068
Query: 2093 PTLEGPE--KFELLLQMP-MGAVLGEPNKTTIFIED 2125
L G + +F + L P GA LG+P+ TTI I D
Sbjct: 1069 SLLRGRQVRRFHVQLSNPKFGAHLGQPHSTTIIIRD 1104
Score = 32.7 bits (73), Expect = 3.9
Identities = 28/117 (23%), Positives = 51/117 (43%), Gaps = 8/117 (6%)
Query: 1775 ICLEKEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNP 1834
+ E+ + V + + RR G S +S T+D TA+ ++D+ ++ F P
Sbjct: 992 VSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNRDY-IPVEGELLFQP 1050
Query: 1835 GQTTATWRVRIIPDNEYET------SETFQIILSEPLM-AVLEFPEMATVEIVDPGD 1884
G+ +V+++ E ++ F + LS P A L P T+ I DP +
Sbjct: 1051 GEAWKELQVKLLELQEVDSLLRGRQVRRFHVQLSNPKFGAHLGQPHSTTIIIRDPDE 1107
>gi|54607035 integrin beta 4 isoform 1 precursor [Homo sapiens]
Length = 1822
Score = 45.4 bits (106), Expect = 6e-04
Identities = 42/156 (26%), Positives = 74/156 (47%), Gaps = 12/156 (7%)
Query: 1975 EEEESFSVSLRLPVG-GQLGARFPTTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCV 2033
+E++ ++ +P G LG R +TI+ ++ + V+ F E+ V+ + + V
Sbjct: 956 DEKQLLVEAIDVPAGTATLGRRL--VNITIIKEQARD-VVSFEQPEFSVSRGDQVARIPV 1012
Query: 2034 WRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILD-DLGQ 2092
RR D + S +++ +A+ DY+ + L F PG + QV +L+
Sbjct: 1013 IRRVLDGGKSQV----SYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVD 1068
Query: 2093 PTLEGPE--KFELLLQMP-MGAVLGEPNKTTIFIED 2125
L G + +F + L P GA LG+P+ TTI I D
Sbjct: 1069 SLLRGRQVRRFHVQLSNPKFGAHLGQPHSTTIIIRD 1104
Score = 32.7 bits (73), Expect = 3.9
Identities = 28/117 (23%), Positives = 51/117 (43%), Gaps = 8/117 (6%)
Query: 1775 ICLEKEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNP 1834
+ E+ + V + + RR G S +S T+D TA+ ++D+ ++ F P
Sbjct: 992 VSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNRDY-IPVEGELLFQP 1050
Query: 1835 GQTTATWRVRIIPDNEYET------SETFQIILSEPLM-AVLEFPEMATVEIVDPGD 1884
G+ +V+++ E ++ F + LS P A L P T+ I DP +
Sbjct: 1051 GEAWKELQVKLLELQEVDSLLRGRQVRRFHVQLSNPKFGAHLGQPHSTTIIIRDPDE 1107
>gi|54607033 integrin beta 4 isoform 3 precursor [Homo sapiens]
Length = 1752
Score = 45.4 bits (106), Expect = 6e-04
Identities = 42/156 (26%), Positives = 74/156 (47%), Gaps = 12/156 (7%)
Query: 1975 EEEESFSVSLRLPVG-GQLGARFPTTKVTILADRYDEPVLHFGDAEYHVNESARYVEVCV 2033
+E++ ++ +P G LG R +TI+ ++ + V+ F E+ V+ + + V
Sbjct: 956 DEKQLLVEAIDVPAGTATLGRRL--VNITIIKEQARD-VVSFEQPEFSVSRGDQVARIPV 1012
Query: 2034 WRRGTDLSQPSSIAVRSRKSEQESAEAGTDYVGISRNLDFAPGVRMQTFQVTILD-DLGQ 2092
RR D + S +++ +A+ DY+ + L F PG + QV +L+
Sbjct: 1013 IRRVLDGGKSQV----SYRTQDGTAQGNRDYIPVEGELLFQPGEAWKELQVKLLELQEVD 1068
Query: 2093 PTLEGPE--KFELLLQMP-MGAVLGEPNKTTIFIED 2125
L G + +F + L P GA LG+P+ TTI I D
Sbjct: 1069 SLLRGRQVRRFHVQLSNPKFGAHLGQPHSTTIIIRD 1104
Score = 32.7 bits (73), Expect = 3.9
Identities = 28/117 (23%), Positives = 51/117 (43%), Gaps = 8/117 (6%)
Query: 1775 ICLEKEYYIVDEDSTFLEVTLTRRGYLGETSFISIGTKDETAKKDKDFKWKTNKQIQFNP 1834
+ E+ + V + + RR G S +S T+D TA+ ++D+ ++ F P
Sbjct: 992 VSFEQPEFSVSRGDQVARIPVIRRVLDGGKSQVSYRTQDGTAQGNRDY-IPVEGELLFQP 1050
Query: 1835 GQTTATWRVRIIPDNEYET------SETFQIILSEPLM-AVLEFPEMATVEIVDPGD 1884
G+ +V+++ E ++ F + LS P A L P T+ I DP +
Sbjct: 1051 GEAWKELQVKLLELQEVDSLLRGRQVRRFHVQLSNPKFGAHLGQPHSTTIIIRDPDE 1107
>gi|115387123 protocadherin 15 isoform CD1-4 precursor [Homo sapiens]
Length = 1955
Score = 43.9 bits (102), Expect = 0.002
Identities = 85/445 (19%), Positives = 168/445 (37%), Gaps = 83/445 (18%)
Query: 1147 RHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEFKVLEG 1206
R++ +Q + + E Q F+ DG+ S V I ++ ND P + V
Sbjct: 461 RYLTLLQPVDRE-EQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVY-- 517
Query: 1207 MSLVIDTQLLNGADADLPPNELHFQLTALP----RHGRIIQQLATGSQPIHSFTLKEIQE 1262
D+ P + QLTA+ +G I ++ G+Q F + +
Sbjct: 518 ------------VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ--GDFIINKTTG 563
Query: 1263 ASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPH-------------L 1309
TI + + + V +D R+ I ++ P+ L
Sbjct: 564 LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623
Query: 1310 TVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNL 1369
++ ++V ++ N L+ATD + D S+++ + +G Q + E L
Sbjct: 624 EISEAMRV----GAVLLN--LQATDREGD--SITYAIENGDPQRVFN-----LSETTGIL 670
Query: 1370 TLGMNFTQDEINRGLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEV 1429
TLG ++ +R ++ I T +G DG +T T + + + VF
Sbjct: 671 TLGKALDRESTDRYIL--IITASDG--------RPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 1430 ISKRITLI-EGARVTLTNNLLTNSDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQ 1488
+ + ++++ E A + T+ D + + H+S+ +L
Sbjct: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNL------------------ 762
Query: 1489 LQLASNKISYVHTSNDEKKMDSFEFQVI---GELYPVFR--TFRIFITDVDNKKPILTIH 1543
++ SN Y + + D +E V+ G ++P T I + D+D+ P+ T
Sbjct: 763 FRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 822
Query: 1544 RLTLQKEDS--QLITLLELTVEDSD 1566
T+ E++ T+L++ +D D
Sbjct: 823 TYTVLVEENLPAGTTILQIEAKDVD 847
>gi|218505798 protocadherin 15 isoform CD1-10 precursor [Homo sapiens]
Length = 1932
Score = 43.9 bits (102), Expect = 0.002
Identities = 85/445 (19%), Positives = 168/445 (37%), Gaps = 83/445 (18%)
Query: 1147 RHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEFKVLEG 1206
R++ +Q + + E Q F+ DG+ S V I ++ ND P + V
Sbjct: 439 RYLTLLQPVDRE-EQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVY-- 495
Query: 1207 MSLVIDTQLLNGADADLPPNELHFQLTALP----RHGRIIQQLATGSQPIHSFTLKEIQE 1262
D+ P + QLTA+ +G I ++ G+Q F + +
Sbjct: 496 ------------VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ--GDFIINKTTG 541
Query: 1263 ASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPH-------------L 1309
TI + + + V +D R+ I ++ P+ L
Sbjct: 542 LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 601
Query: 1310 TVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNL 1369
++ ++V ++ N L+ATD + D S+++ + +G Q + E L
Sbjct: 602 EISEAMRV----GAVLLN--LQATDREGD--SITYAIENGDPQRVFN-----LSETTGIL 648
Query: 1370 TLGMNFTQDEINRGLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEV 1429
TLG ++ +R ++ I T +G DG +T T + + + VF
Sbjct: 649 TLGKALDRESTDRYIL--IITASDG--------RPDGTSTATVNIVVTDVNDNAPVFDPY 698
Query: 1430 ISKRITLI-EGARVTLTNNLLTNSDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQ 1488
+ + ++++ E A + T+ D + + H+S+ +L
Sbjct: 699 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNL------------------ 740
Query: 1489 LQLASNKISYVHTSNDEKKMDSFEFQVI---GELYPVFR--TFRIFITDVDNKKPILTIH 1543
++ SN Y + + D +E V+ G ++P T I + D+D+ P+ T
Sbjct: 741 FRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 800
Query: 1544 RLTLQKEDS--QLITLLELTVEDSD 1566
T+ E++ T+L++ +D D
Sbjct: 801 TYTVLVEENLPAGTTILQIEAKDVD 825
>gi|218505793 protocadherin 15 isoform CD3-2 precursor [Homo sapiens]
Length = 1677
Score = 43.9 bits (102), Expect = 0.002
Identities = 85/445 (19%), Positives = 168/445 (37%), Gaps = 83/445 (18%)
Query: 1147 RHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEFKVLEG 1206
R++ +Q + + E Q F+ DG+ S V I ++ ND P + V
Sbjct: 461 RYLTLLQPVDRE-EQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVY-- 517
Query: 1207 MSLVIDTQLLNGADADLPPNELHFQLTALP----RHGRIIQQLATGSQPIHSFTLKEIQE 1262
D+ P + QLTA+ +G I ++ G+Q F + +
Sbjct: 518 ------------VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ--GDFIINKTTG 563
Query: 1263 ASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPH-------------L 1309
TI + + + V +D R+ I ++ P+ L
Sbjct: 564 LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623
Query: 1310 TVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNL 1369
++ ++V ++ N L+ATD + D S+++ + +G Q + E L
Sbjct: 624 EISEAMRV----GAVLLN--LQATDREGD--SITYAIENGDPQRVFN-----LSETTGIL 670
Query: 1370 TLGMNFTQDEINRGLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEV 1429
TLG ++ +R ++ I T +G DG +T T + + + VF
Sbjct: 671 TLGKALDRESTDRYIL--IITASDG--------RPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 1430 ISKRITLI-EGARVTLTNNLLTNSDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQ 1488
+ + ++++ E A + T+ D + + H+S+ +L
Sbjct: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNL------------------ 762
Query: 1489 LQLASNKISYVHTSNDEKKMDSFEFQVI---GELYPVFR--TFRIFITDVDNKKPILTIH 1543
++ SN Y + + D +E V+ G ++P T I + D+D+ P+ T
Sbjct: 763 FRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 822
Query: 1544 RLTLQKEDS--QLITLLELTVEDSD 1566
T+ E++ T+L++ +D D
Sbjct: 823 TYTVLVEENLPAGTTILQIEAKDVD 847
>gi|218505791 protocadherin 15 isoform CD3-1 precursor [Homo sapiens]
Length = 1682
Score = 43.9 bits (102), Expect = 0.002
Identities = 85/445 (19%), Positives = 168/445 (37%), Gaps = 83/445 (18%)
Query: 1147 RHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEFKVLEG 1206
R++ +Q + + E Q F+ DG+ S V I ++ ND P + V
Sbjct: 466 RYLTLLQPVDRE-EQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVY-- 522
Query: 1207 MSLVIDTQLLNGADADLPPNELHFQLTALP----RHGRIIQQLATGSQPIHSFTLKEIQE 1262
D+ P + QLTA+ +G I ++ G+Q F + +
Sbjct: 523 ------------VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ--GDFIINKTTG 568
Query: 1263 ASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPH-------------L 1309
TI + + + V +D R+ I ++ P+ L
Sbjct: 569 LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 628
Query: 1310 TVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNL 1369
++ ++V ++ N L+ATD + D S+++ + +G Q + E L
Sbjct: 629 EISEAMRV----GAVLLN--LQATDREGD--SITYAIENGDPQRVFN-----LSETTGIL 675
Query: 1370 TLGMNFTQDEINRGLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEV 1429
TLG ++ +R ++ I T +G DG +T T + + + VF
Sbjct: 676 TLGKALDRESTDRYIL--IITASDG--------RPDGTSTATVNIVVTDVNDNAPVFDPY 725
Query: 1430 ISKRITLI-EGARVTLTNNLLTNSDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQ 1488
+ + ++++ E A + T+ D + + H+S+ +L
Sbjct: 726 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNL------------------ 767
Query: 1489 LQLASNKISYVHTSNDEKKMDSFEFQVI---GELYPVFR--TFRIFITDVDNKKPILTIH 1543
++ SN Y + + D +E V+ G ++P T I + D+D+ P+ T
Sbjct: 768 FRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 827
Query: 1544 RLTLQKEDS--QLITLLELTVEDSD 1566
T+ E++ T+L++ +D D
Sbjct: 828 TYTVLVEENLPAGTTILQIEAKDVD 852
>gi|218505789 protocadherin 15 isoform CD2-2 precursor [Homo sapiens]
Length = 1539
Score = 43.9 bits (102), Expect = 0.002
Identities = 85/445 (19%), Positives = 168/445 (37%), Gaps = 83/445 (18%)
Query: 1147 RHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEFKVLEG 1206
R++ +Q + + E Q F+ DG+ S V I ++ ND P + V
Sbjct: 461 RYLTLLQPVDRE-EQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVY-- 517
Query: 1207 MSLVIDTQLLNGADADLPPNELHFQLTALP----RHGRIIQQLATGSQPIHSFTLKEIQE 1262
D+ P + QLTA+ +G I ++ G+Q F + +
Sbjct: 518 ------------VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ--GDFIINKTTG 563
Query: 1263 ASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPH-------------L 1309
TI + + + V +D R+ I ++ P+ L
Sbjct: 564 LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623
Query: 1310 TVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNL 1369
++ ++V ++ N L+ATD + D S+++ + +G Q + E L
Sbjct: 624 EISEAMRV----GAVLLN--LQATDREGD--SITYAIENGDPQRVFN-----LSETTGIL 670
Query: 1370 TLGMNFTQDEINRGLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEV 1429
TLG ++ +R ++ I T +G DG +T T + + + VF
Sbjct: 671 TLGKALDRESTDRYIL--IITASDG--------RPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 1430 ISKRITLI-EGARVTLTNNLLTNSDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQ 1488
+ + ++++ E A + T+ D + + H+S+ +L
Sbjct: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNL------------------ 762
Query: 1489 LQLASNKISYVHTSNDEKKMDSFEFQVI---GELYPVFR--TFRIFITDVDNKKPILTIH 1543
++ SN Y + + D +E V+ G ++P T I + D+D+ P+ T
Sbjct: 763 FRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 822
Query: 1544 RLTLQKEDS--QLITLLELTVEDSD 1566
T+ E++ T+L++ +D D
Sbjct: 823 TYTVLVEENLPAGTTILQIEAKDVD 847
>gi|218505787 protocadherin 15 isoform CD2-1 precursor [Homo sapiens]
Length = 1790
Score = 43.9 bits (102), Expect = 0.002
Identities = 85/445 (19%), Positives = 168/445 (37%), Gaps = 83/445 (18%)
Query: 1147 RHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEFKVLEG 1206
R++ +Q + + E Q F+ DG+ S V I ++ ND P + V
Sbjct: 473 RYLTLLQPVDRE-EQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVY-- 529
Query: 1207 MSLVIDTQLLNGADADLPPNELHFQLTALP----RHGRIIQQLATGSQPIHSFTLKEIQE 1262
D+ P + QLTA+ +G I ++ G+Q F + +
Sbjct: 530 ------------VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ--GDFIINKTTG 575
Query: 1263 ASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPH-------------L 1309
TI + + + V +D R+ I ++ P+ L
Sbjct: 576 LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 635
Query: 1310 TVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNL 1369
++ ++V ++ N L+ATD + D S+++ + +G Q + E L
Sbjct: 636 EISEAMRV----GAVLLN--LQATDREGD--SITYAIENGDPQRVFN-----LSETTGIL 682
Query: 1370 TLGMNFTQDEINRGLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEV 1429
TLG ++ +R ++ I T +G DG +T T + + + VF
Sbjct: 683 TLGKALDRESTDRYIL--IITASDG--------RPDGTSTATVNIVVTDVNDNAPVFDPY 732
Query: 1430 ISKRITLI-EGARVTLTNNLLTNSDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQ 1488
+ + ++++ E A + T+ D + + H+S+ +L
Sbjct: 733 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNL------------------ 774
Query: 1489 LQLASNKISYVHTSNDEKKMDSFEFQVI---GELYPVFR--TFRIFITDVDNKKPILTIH 1543
++ SN Y + + D +E V+ G ++P T I + D+D+ P+ T
Sbjct: 775 FRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 834
Query: 1544 RLTLQKEDS--QLITLLELTVEDSD 1566
T+ E++ T+L++ +D D
Sbjct: 835 TYTVLVEENLPAGTTILQIEAKDVD 859
>gi|218505785 protocadherin 15 isoform CD1-9 precursor [Homo sapiens]
Length = 1935
Score = 43.9 bits (102), Expect = 0.002
Identities = 85/445 (19%), Positives = 168/445 (37%), Gaps = 83/445 (18%)
Query: 1147 RHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEFKVLEG 1206
R++ +Q + + E Q F+ DG+ S V I ++ ND P + V
Sbjct: 439 RYLTLLQPVDRE-EQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVY-- 495
Query: 1207 MSLVIDTQLLNGADADLPPNELHFQLTALP----RHGRIIQQLATGSQPIHSFTLKEIQE 1262
D+ P + QLTA+ +G I ++ G+Q F + +
Sbjct: 496 ------------VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ--GDFIINKTTG 541
Query: 1263 ASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPH-------------L 1309
TI + + + V +D R+ I ++ P+ L
Sbjct: 542 LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 601
Query: 1310 TVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNL 1369
++ ++V ++ N L+ATD + D S+++ + +G Q + E L
Sbjct: 602 EISEAMRV----GAVLLN--LQATDREGD--SITYAIENGDPQRVFN-----LSETTGIL 648
Query: 1370 TLGMNFTQDEINRGLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEV 1429
TLG ++ +R ++ I T +G DG +T T + + + VF
Sbjct: 649 TLGKALDRESTDRYIL--IITASDG--------RPDGTSTATVNIVVTDVNDNAPVFDPY 698
Query: 1430 ISKRITLI-EGARVTLTNNLLTNSDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQ 1488
+ + ++++ E A + T+ D + + H+S+ +L
Sbjct: 699 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNL------------------ 740
Query: 1489 LQLASNKISYVHTSNDEKKMDSFEFQVI---GELYPVFR--TFRIFITDVDNKKPILTIH 1543
++ SN Y + + D +E V+ G ++P T I + D+D+ P+ T
Sbjct: 741 FRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 800
Query: 1544 RLTLQKEDS--QLITLLELTVEDSD 1566
T+ E++ T+L++ +D D
Sbjct: 801 TYTVLVEENLPAGTTILQIEAKDVD 825
>gi|218505783 protocadherin 15 isoform CD1-8 precursor [Homo sapiens]
Length = 1915
Score = 43.9 bits (102), Expect = 0.002
Identities = 85/445 (19%), Positives = 168/445 (37%), Gaps = 83/445 (18%)
Query: 1147 RHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEFKVLEG 1206
R++ +Q + + E Q F+ DG+ S V I ++ ND P + V
Sbjct: 424 RYLTLLQPVDRE-EQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVY-- 480
Query: 1207 MSLVIDTQLLNGADADLPPNELHFQLTALP----RHGRIIQQLATGSQPIHSFTLKEIQE 1262
D+ P + QLTA+ +G I ++ G+Q F + +
Sbjct: 481 ------------VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ--GDFIINKTTG 526
Query: 1263 ASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPH-------------L 1309
TI + + + V +D R+ I ++ P+ L
Sbjct: 527 LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 586
Query: 1310 TVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNL 1369
++ ++V ++ N L+ATD + D S+++ + +G Q + E L
Sbjct: 587 EISEAMRV----GAVLLN--LQATDREGD--SITYAIENGDPQRVFN-----LSETTGIL 633
Query: 1370 TLGMNFTQDEINRGLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEV 1429
TLG ++ +R ++ I T +G DG +T T + + + VF
Sbjct: 634 TLGKALDRESTDRYIL--IITASDG--------RPDGTSTATVNIVVTDVNDNAPVFDPY 683
Query: 1430 ISKRITLI-EGARVTLTNNLLTNSDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQ 1488
+ + ++++ E A + T+ D + + H+S+ +L
Sbjct: 684 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNL------------------ 725
Query: 1489 LQLASNKISYVHTSNDEKKMDSFEFQVI---GELYPVFR--TFRIFITDVDNKKPILTIH 1543
++ SN Y + + D +E V+ G ++P T I + D+D+ P+ T
Sbjct: 726 FRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 785
Query: 1544 RLTLQKEDS--QLITLLELTVEDSD 1566
T+ E++ T+L++ +D D
Sbjct: 786 TYTVLVEENLPAGTTILQIEAKDVD 810
>gi|218505781 protocadherin 15 isoform CD1-7 precursor [Homo sapiens]
Length = 1952
Score = 43.9 bits (102), Expect = 0.002
Identities = 85/445 (19%), Positives = 168/445 (37%), Gaps = 83/445 (18%)
Query: 1147 RHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEFKVLEG 1206
R++ +Q + + E Q F+ DG+ S V I ++ ND P + V
Sbjct: 461 RYLTLLQPVDRE-EQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVY-- 517
Query: 1207 MSLVIDTQLLNGADADLPPNELHFQLTALP----RHGRIIQQLATGSQPIHSFTLKEIQE 1262
D+ P + QLTA+ +G I ++ G+Q F + +
Sbjct: 518 ------------VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ--GDFIINKTTG 563
Query: 1263 ASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPH-------------L 1309
TI + + + V +D R+ I ++ P+ L
Sbjct: 564 LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623
Query: 1310 TVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNL 1369
++ ++V ++ N L+ATD + D S+++ + +G Q + E L
Sbjct: 624 EISEAMRV----GAVLLN--LQATDREGD--SITYAIENGDPQRVFN-----LSETTGIL 670
Query: 1370 TLGMNFTQDEINRGLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEV 1429
TLG ++ +R ++ I T +G DG +T T + + + VF
Sbjct: 671 TLGKALDRESTDRYIL--IITASDG--------RPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 1430 ISKRITLI-EGARVTLTNNLLTNSDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQ 1488
+ + ++++ E A + T+ D + + H+S+ +L
Sbjct: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNL------------------ 762
Query: 1489 LQLASNKISYVHTSNDEKKMDSFEFQVI---GELYPVFR--TFRIFITDVDNKKPILTIH 1543
++ SN Y + + D +E V+ G ++P T I + D+D+ P+ T
Sbjct: 763 FRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 822
Query: 1544 RLTLQKEDS--QLITLLELTVEDSD 1566
T+ E++ T+L++ +D D
Sbjct: 823 TYTVLVEENLPAGTTILQIEAKDVD 847
>gi|218505777 protocadherin 15 isoform CD1-2 precursor [Homo sapiens]
Length = 1957
Score = 43.9 bits (102), Expect = 0.002
Identities = 85/445 (19%), Positives = 168/445 (37%), Gaps = 83/445 (18%)
Query: 1147 RHINYVQSIHKGVEPQEDQFTFYCSDGINFSPNVFFPIIILPTNDEQPKLFAHEFKVLEG 1206
R++ +Q + + E Q F+ DG+ S V I ++ ND P + V
Sbjct: 461 RYLTLLQPVDRE-EQQTYTFSITAFDGVQESEPVIVNIQVMDANDNTPTFPEISYDVY-- 517
Query: 1207 MSLVIDTQLLNGADADLPPNELHFQLTALP----RHGRIIQQLATGSQPIHSFTLKEIQE 1262
D+ P + QLTA+ +G I ++ G+Q F + +
Sbjct: 518 ------------VYTDMRPGDSVIQLTAVDADEGSNGEITYEILVGAQ--GDFIINKTTG 563
Query: 1263 ASTIVYEHDDSETKEDSFEVWLSDGKHTTHRKVPIVVTLVDDETPH-------------L 1309
TI + + + V +D R+ I ++ P+ L
Sbjct: 564 LITIAPGVEMIVGRTYALTVQAADNAPPAERRNSICTVYIEVLPPNNQSPPRFPQLMYSL 623
Query: 1310 TVNNGLKVEKGHSEIITNRILKATDLDSDDKSLSFVLHSGPQQGLLQRLRKPRGEVRNNL 1369
++ ++V ++ N L+ATD + D S+++ + +G Q + E L
Sbjct: 624 EISEAMRV----GAVLLN--LQATDREGD--SITYAIENGDPQRVFN-----LSETTGIL 670
Query: 1370 TLGMNFTQDEINRGLICYIHTGQEGIVDIIKFDVTDGVNTLTDHYFYVTIGNLDSVFPEV 1429
TLG ++ +R ++ I T +G DG +T T + + + VF
Sbjct: 671 TLGKALDRESTDRYIL--IITASDG--------RPDGTSTATVNIVVTDVNDNAPVFDPY 720
Query: 1430 ISKRITLI-EGARVTLTNNLLTNSDINSSDEHHFSITRAPSLGHLESSDYAGEPIASFTQ 1488
+ + ++++ E A + T+ D + + H+S+ +L
Sbjct: 721 LPRNLSVVEEEANAFVGQVKATDPDAGINGQVHYSLGNFNNL------------------ 762
Query: 1489 LQLASNKISYVHTSNDEKKMDSFEFQVI---GELYPVFR--TFRIFITDVDNKKPILTIH 1543
++ SN Y + + D +E V+ G ++P T I + D+D+ P+ T
Sbjct: 763 FRITSNGSIYTAVKLNREVRDYYELVVVATDGAVHPRHSTLTLAIKVLDIDDNSPVFTNS 822
Query: 1544 RLTLQKEDS--QLITLLELTVEDSD 1566
T+ E++ T+L++ +D D
Sbjct: 823 TYTVLVEENLPAGTTILQIEAKDVD 847
Database: hs.faa
Posted date: Aug 4, 2009 4:42 PM
Number of letters in database: 18,247,518
Number of sequences in database: 37,866
Lambda K H
0.318 0.136 0.397
Gapped
Lambda K H
0.267 0.0410 0.140
Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 85,519,315
Number of Sequences: 37866
Number of extensions: 4141268
Number of successful extensions: 10165
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 25
Number of HSP's successfully gapped in prelim test: 44
Number of HSP's that attempted gapping in prelim test: 9173
Number of HSP's gapped (non-prelim): 252
length of query: 2139
length of database: 18,247,518
effective HSP length: 118
effective length of query: 2021
effective length of database: 13,779,330
effective search space: 27848025930
effective search space used: 27848025930
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.7 bits)
S2: 70 (31.6 bits)
Search results were obtained with NCBI BLAST and RefSeq entries.
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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.