Search of human proteins with 168986655

BLASTP 2.2.11 [Jun-05-2005]


Reference: Altschul, Stephen F., Thomas L. Madden, Alejandro A. Schaffer, 
Jinghui Zhang, Zheng Zhang, Webb Miller, and David J. Lipman (1997), 
"Gapped BLAST and PSI-BLAST: a new generation of protein database search
programs",  Nucleic Acids Res. 25:3389-3402.

Query= gi|168986655 hypothetical protein LOC145497 [Homo sapiens]
         (488 letters)

Database: hs.faa 
           37,866 sequences; 18,247,518 total letters

Searching..................................................done

                                                                 Score    E
Sequences producing significant alignments:                      (bits) Value

gi|168986655 hypothetical protein LOC145497 [Homo sapiens]            968   0.0  
gi|118918429 NOD3 protein [Homo sapiens]                              132   9e-31
gi|21450705 leucine rich repeat containing 45 [Homo sapiens]           91   2e-18
gi|23503285 leucine rich repeat containing 34 [Homo sapiens]           90   4e-18
gi|116268109 nucleotide-binding oligomerization domains 27 [Homo...    85   2e-16
gi|229577123 t-complex-associated testis expressed 1 [Homo sapiens]    82   1e-15
gi|5174617 nucleotide-binding oligomerization domain containing ...    81   2e-15
gi|11545912 nucleotide-binding oligomerization domain containing...    79   7e-15
gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]    73   7e-13
gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Ho...    72   1e-12
gi|169213924 PREDICTED: leucine rich repeat containing 68 [Homo ...    70   6e-12
gi|169214345 PREDICTED: leucine rich repeat containing 68 [Homo ...    70   6e-12
gi|169213302 PREDICTED: leucine rich repeat containing 68 [Homo ...    70   6e-12
gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]      70   6e-12
gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [H...    68   2e-11
gi|4506411 Ran GTPase activating protein 1 [Homo sapiens]              66   8e-11
gi|119395764 NLR family, pyrin domain containing 3 isoform a [Ho...    65   2e-10
gi|34878693 NLR family, pyrin domain containing 3 isoform a [Hom...    65   2e-10
gi|188536116 NLR family, pyrin domain containing 3 isoform c [Ho...    64   2e-10
gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]           64   2e-10
gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]           64   2e-10
gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]           64   2e-10
gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]           64   2e-10
gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]           64   2e-10
gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]           64   2e-10
gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens]           64   2e-10
gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens]           64   2e-10
gi|63054866 leucine rich repeat containing 16A [Homo sapiens]          63   5e-10
gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]        60   6e-09
gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]     58   2e-08

>gi|168986655 hypothetical protein LOC145497 [Homo sapiens]
          Length = 488

 Score =  968 bits (2502), Expect = 0.0
 Identities = 488/488 (100%), Positives = 488/488 (100%)

Query: 1   MHIQFPSKPTLPRACWEGRITAGSPGMPPDEIEIEPVRQSSDKMLYCEAESPPTVEKVKP 60
           MHIQFPSKPTLPRACWEGRITAGSPGMPPDEIEIEPVRQSSDKMLYCEAESPPTVEKVKP
Sbjct: 1   MHIQFPSKPTLPRACWEGRITAGSPGMPPDEIEIEPVRQSSDKMLYCEAESPPTVEKVKP 60

Query: 61  ARENSETDLEIEDDEKFFTTGQKELYLEACKLMGVVPVSYFIRNMEESYVNLNHHGLGPR 120
           ARENSETDLEIEDDEKFFTTGQKELYLEACKLMGVVPVSYFIRNMEESYVNLNHHGLGPR
Sbjct: 61  ARENSETDLEIEDDEKFFTTGQKELYLEACKLMGVVPVSYFIRNMEESYVNLNHHGLGPR 120

Query: 121 GTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARI 180
           GTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARI
Sbjct: 121 GTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARI 180

Query: 181 ISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQ 240
           ISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQ
Sbjct: 181 ISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQ 240

Query: 241 MLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRL 300
           MLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRL
Sbjct: 241 MLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRL 300

Query: 301 NRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAILLILAIKRNPKS 360
           NRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAILLILAIKRNPKS
Sbjct: 301 NRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAILLILAIKRNPKS 360

Query: 361 RMEELDISNVLVSEQFMKTLDGVYAVHPQLDVVFKAVQGLSPKKTIFLLTNPMKLIQSYA 420
           RMEELDISNVLVSEQFMKTLDGVYAVHPQLDVVFKAVQGLSPKKTIFLLTNPMKLIQSYA
Sbjct: 361 RMEELDISNVLVSEQFMKTLDGVYAVHPQLDVVFKAVQGLSPKKTIFLLTNPMKLIQSYA 420

Query: 421 DQHKITIVDFFKSLNPTGTMKMSVDEFQKVMIEQNKVPLNQYQVREVIKKLDEKTGMVNF 480
           DQHKITIVDFFKSLNPTGTMKMSVDEFQKVMIEQNKVPLNQYQVREVIKKLDEKTGMVNF
Sbjct: 421 DQHKITIVDFFKSLNPTGTMKMSVDEFQKVMIEQNKVPLNQYQVREVIKKLDEKTGMVNF 480

Query: 481 SFLNTMKP 488
           SFLNTMKP
Sbjct: 481 SFLNTMKP 488


>gi|118918429 NOD3 protein [Homo sapiens]
          Length = 1065

 Score =  132 bits (331), Expect = 9e-31
 Identities = 90/255 (35%), Positives = 130/255 (50%), Gaps = 3/255 (1%)

Query: 103  RNMEESYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYY 162
            R+++E   + N   +G  G KA+A AL  N  +  L+L+ N I + GV +L+  L  N  
Sbjct: 778  RSLKELMFSSN--SIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTNQT 835

Query: 163  LQEMNISNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKK 222
            L  +++  N +  EGA+ I+     NS+ + +L+L+ N   +  A  +  A+  N  +  
Sbjct: 836  LLSLSLRENSISPEGAQAIAHALCANST-LKNLDLTANLLHDQGARAIAVAVRENRTLTS 894

Query: 223  LDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLS 282
            L L  N       + LGQ L +N  LTSLDL  N     GA A+   L+ N  LT L L 
Sbjct: 895  LHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIGDDGACAVARALKVNTALTALYLQ 954

Query: 283  MNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPI 342
            +   G   A  LGE L +NR L  LD+ GN IG  GA  ++  L+ N SLR L L  N +
Sbjct: 955  VASIGASGAQVLGEALAVNRTLEILDLRGNAIGVAGAKALANALKVNSSLRRLNLQENSL 1014

Query: 343  NMDGAILLILAIKRN 357
             MDGAI +  A+  N
Sbjct: 1015 GMDGAICIATALSGN 1029



 Score =  131 bits (330), Expect = 1e-30
 Identities = 97/317 (30%), Positives = 148/317 (46%), Gaps = 35/317 (11%)

Query: 104  NMEESYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYL 163
            N   + ++L  + +GP+G KA+A AL  N  +T L L+ N + ++G  S+ E L  N  L
Sbjct: 693  NRSLTSLDLRGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTL 752

Query: 164  QEMNISNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKL 223
              +++  N +G  GA+ ++D  ++N S +  L  S N   +  A  L +AL  N  ++ L
Sbjct: 753  SMLHLQKNSIGPMGAQRMADALKQNRS-LKELMFSSNSIGDGGAKALAEALKVNQGLESL 811

Query: 224  DLSHNQFSDV----------------------------GGEHLGQMLAINVGLTSLDLSW 255
            DL  N  SD                             G + +   L  N  L +LDL+ 
Sbjct: 812  DLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLTA 871

Query: 256  NNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIG 315
            N  H +GA A+   +R N TLT L L  N      A ALG+ L+LNR L  LD+  N IG
Sbjct: 872  NLLHDQGARAIAVAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENAIG 931

Query: 316  NEGASKISKGLESNESLRVLKLFLNPINMDGAILL--ILAIKRNPKSRMEELDISNVLVS 373
            ++GA  +++ L+ N +L  L L +  I   GA +L   LA+ R     +E LD+    + 
Sbjct: 932  DDGACAVARALKVNTALTALYLQVASIGASGAQVLGEALAVNRT----LEILDLRGNAIG 987

Query: 374  EQFMKTLDGVYAVHPQL 390
                K L     V+  L
Sbjct: 988  VAGAKALANALKVNSSL 1004



 Score =  108 bits (269), Expect = 1e-23
 Identities = 80/248 (32%), Positives = 119/248 (47%), Gaps = 1/248 (0%)

Query: 110  VNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNIS 169
            ++L  + +   G  A+  AL +N  +  L L +N I  EG  ++   L  N  L+ ++++
Sbjct: 811  LDLQSNSISDAGVAALMGALCTNQTLLSLSLRENSISPEGAQAIAHALCANSTLKNLDLT 870

Query: 170  NNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQ 229
             N L  +GAR I+    R + ++ SL L  N  +  +A  L QAL  N  +  LDL  N 
Sbjct: 871  ANLLHDQGARAIA-VAVRENRTLTSLHLQWNFIQAGAAQALGQALQLNRSLTSLDLQENA 929

Query: 230  FSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNE 289
              D G   + + L +N  LT+L L   +    GA  L   L  N TL  LDL  N  G  
Sbjct: 930  IGDDGACAVARALKVNTALTALYLQVASIGASGAQVLGEALAVNRTLEILDLRGNAIGVA 989

Query: 290  VALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAIL 349
             A AL   L++N  L  L++  N +G +GA  I+  L  N  L+ + L  N I   GA +
Sbjct: 990  GAKALANALKVNSSLRRLNLQENSLGMDGAICIATALSGNHRLQHINLQGNHIGDSGARM 1049

Query: 350  LILAIKRN 357
            +  AIK N
Sbjct: 1050 ISEAIKTN 1057



 Score = 98.2 bits (243), Expect = 1e-20
 Identities = 71/210 (33%), Positives = 107/210 (50%), Gaps = 3/210 (1%)

Query: 195 LELSGNDFKEDSAALLCQALS-TNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDL 253
           L L  N F++    LL   LS  + +I+K+ L+ NQ S+ G + L + L +N  LTSLDL
Sbjct: 642 LRLDTNQFQDPVMELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDL 701

Query: 254 SWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGND 313
             N+   +GA AL + L+ N TLT L L  N   ++ A ++ E L  NR L  L +  N 
Sbjct: 702 RGNSIGPQGAKALADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNS 761

Query: 314 IGNEGASKISKGLESNESLRVLKLFLNPINMDGAILLILAIKRNPKSRMEELDISNVLVS 373
           IG  GA +++  L+ N SL+ L    N I   GA  L  A+K N    +E LD+ +  +S
Sbjct: 762 IGPMGAQRMADALKQNRSLKELMFSSNSIGDGGAKALAEALKVN--QGLESLDLQSNSIS 819

Query: 374 EQFMKTLDGVYAVHPQLDVVFKAVQGLSPK 403
           +  +  L G    +  L  +      +SP+
Sbjct: 820 DAGVAALMGALCTNQTLLSLSLRENSISPE 849



 Score = 88.6 bits (218), Expect = 1e-17
 Identities = 74/275 (26%), Positives = 114/275 (41%), Gaps = 14/275 (5%)

Query: 118 GPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEG 177
           GP    A+A  L  + A  + E   +  + +GVL    +L +  Y +++ +  N      
Sbjct: 597 GPAHRAALAYLLQVSDACAQ-EANLSLSLSQGVLQ--SLLPQLLYCRKLRLDTNQFQDPV 653

Query: 178 ARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEH 237
             ++          I  + L+ N      A  L ++L  N  +  LDL  N     G + 
Sbjct: 654 MELLGSVLSGKDCRIQKISLAENQISNKGAKALARSLLVNRSLTSLDLRGNSIGPQGAKA 713

Query: 238 LGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEV 297
           L   L IN  LTSL L  N     GA ++   L  N TL+ L L  N  G   A  + + 
Sbjct: 714 LADALKINRTLTSLSLQGNTVRDDGARSMAEALASNRTLSMLHLQKNSIGPMGAQRMADA 773

Query: 298 LRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGA---------- 347
           L+ NR L  L    N IG+ GA  +++ L+ N+ L  L L  N I+  G           
Sbjct: 774 LKQNRSLKELMFSSNSIGDGGAKALAEALKVNQGLESLDLQSNSISDAGVAALMGALCTN 833

Query: 348 -ILLILAIKRNPKSRMEELDISNVLVSEQFMKTLD 381
             LL L+++ N  S      I++ L +   +K LD
Sbjct: 834 QTLLSLSLRENSISPEGAQAIAHALCANSTLKNLD 868



 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 27/80 (33%), Positives = 49/80 (61%)

Query: 110  VNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNIS 169
            ++L  + +G  G KA+A AL  N ++ +L L++N +  +G + +   L  N+ LQ +N+ 
Sbjct: 979  LDLRGNAIGVAGAKALANALKVNSSLRRLNLQENSLGMDGAICIATALSGNHRLQHINLQ 1038

Query: 170  NNHLGLEGARIISDFFERNS 189
             NH+G  GAR+IS+  + N+
Sbjct: 1039 GNHIGDSGARMISEAIKTNA 1058


>gi|21450705 leucine rich repeat containing 45 [Homo sapiens]
          Length = 670

 Score = 91.3 bits (225), Expect = 2e-18
 Identities = 67/218 (30%), Positives = 100/218 (45%), Gaps = 6/218 (2%)

Query: 86  YLEACKLMGVVPVSYFIRNMEE---SYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELED 142
           Y   C+  G  P    ++ + +     ++L    L     +A+   L      T+L L D
Sbjct: 8   YSRLCRESGAEPQEAVLQQLHQLPRGRLDLATQSLTVETCRALGKLLPRETLCTELVLSD 67

Query: 143 NCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNSSSIWSLELSGNDF 202
             + EEG   L+  L  N  L+ +++  N+L   GA  +    ++N S I SL L  N  
Sbjct: 68  CMLSEEGATLLLRGLCANTVLRFLDLKGNNLRAAGAEALGKLLQQNKS-IQSLTLEWNSL 126

Query: 203 K--EDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHT 260
              +D+ A  C  L+ N  +++LDL +NQ S  G E L   L  N  L  LDL WNN   
Sbjct: 127 GTWDDAFATFCGGLAANGALQRLDLRNNQISHKGAEELALALKGNTTLQQLDLRWNNVGL 186

Query: 261 RGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVL 298
            G  AL N L  N TL +LDL+ N    +V  A+ + +
Sbjct: 187 LGGRALMNCLPSNRTLWRLDLAGNNIPGDVLRAVEQAM 224



 Score = 75.5 bits (184), Expect = 1e-13
 Identities = 64/216 (29%), Positives = 94/216 (43%), Gaps = 9/216 (4%)

Query: 136 TKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNSSSIWSL 195
           ++L  E     +E VL  +  L        ++++   L +E  R +     R +     L
Sbjct: 9   SRLCRESGAEPQEAVLQQLHQLPRG----RLDLATQSLTVETCRALGKLLPRETLCT-EL 63

Query: 196 ELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSW 255
            LS     E+ A LL + L  N  ++ LDL  N     G E LG++L  N  + SL L W
Sbjct: 64  VLSDCMLSEEGATLLLRGLCANTVLRFLDLKGNNLRAAGAEALGKLLQQNKSIQSLTLEW 123

Query: 256 NNFHT--RGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGND 313
           N+  T        C GL  N  L +LDL  N   ++ A  L   L+ N  L  LD+  N+
Sbjct: 124 NSLGTWDDAFATFCGGLAANGALQRLDLRNNQISHKGAEELALALKGNTTLQQLDLRWNN 183

Query: 314 IGNEGASKISKGLESNESLRVLKLFLNPINMDGAIL 349
           +G  G   +   L SN +L  L L  N  N+ G +L
Sbjct: 184 VGLLGGRALMNCLPSNRTLWRLDLAGN--NIPGDVL 217



 Score = 55.1 bits (131), Expect = 1e-07
 Identities = 48/151 (31%), Positives = 71/151 (47%), Gaps = 2/151 (1%)

Query: 222 KLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDL 281
           +LDL+    +      LG++L      T L LS       GA  L  GL  N  L  LDL
Sbjct: 34  RLDLATQSLTVETCRALGKLLPRETLCTELVLSDCMLSEEGATLLLRGLCANTVLRFLDL 93

Query: 282 SMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIG--NEGASKISKGLESNESLRVLKLFL 339
             N      A ALG++L+ N+ +  L +  N +G  ++  +    GL +N +L+ L L  
Sbjct: 94  KGNNLRAAGAEALGKLLQQNKSIQSLTLEWNSLGTWDDAFATFCGGLAANGALQRLDLRN 153

Query: 340 NPINMDGAILLILAIKRNPKSRMEELDISNV 370
           N I+  GA  L LA+K N   +  +L  +NV
Sbjct: 154 NQISHKGAEELALALKGNTTLQQLDLRWNNV 184



 Score = 33.1 bits (74), Expect = 0.59
 Identities = 29/113 (25%), Positives = 50/113 (44%)

Query: 278 KLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKL 337
           +LDL+      E   ALG++L        L +    +  EGA+ + +GL +N  LR L L
Sbjct: 34  RLDLATQSLTVETCRALGKLLPRETLCTELVLSDCMLSEEGATLLLRGLCANTVLRFLDL 93

Query: 338 FLNPINMDGAILLILAIKRNPKSRMEELDISNVLVSEQFMKTLDGVYAVHPQL 390
             N +   GA  L   +++N   +   L+ +++   +    T  G  A +  L
Sbjct: 94  KGNNLRAAGAEALGKLLQQNKSIQSLTLEWNSLGTWDDAFATFCGGLAANGAL 146


>gi|23503285 leucine rich repeat containing 34 [Homo sapiens]
          Length = 419

 Score = 90.1 bits (222), Expect = 4e-18
 Identities = 63/224 (28%), Positives = 110/224 (49%), Gaps = 3/224 (1%)

Query: 135 VTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNSSSIWS 194
           +  L++  N + + G     ++LQ+   L  +N+  N +G EG  +I+    +N +  + 
Sbjct: 112 INGLDVGYNLLCDVGAYYAAKLLQKQLNLIYLNLMFNDIGPEGGELIAKVLHKNRTLKY- 170

Query: 195 LELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLS 254
           L ++GN  +          L  N  ++KLDL      +    H+G+ML  N  L +L + 
Sbjct: 171 LRMTGNKIENKGGMFFAAMLQINSSLEKLDLGDCDLEE-STVHVGRMLKENHCLVALHMC 229

Query: 255 WNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDI 314
            ++    G   LC+ L  N +L  LD+S N   ++  + L +VL+ N  L  +D+  N I
Sbjct: 230 KHDIKNSGIQQLCDALYLNSSLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRI 289

Query: 315 GNEGASKISKGLES-NESLRVLKLFLNPINMDGAILLILAIKRN 357
            N GA+ +S+ L S N SL+ L +  N I  +G + L  ++K N
Sbjct: 290 ENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTN 333



 Score = 77.8 bits (190), Expect = 2e-14
 Identities = 57/205 (27%), Positives = 96/205 (46%), Gaps = 3/205 (1%)

Query: 109 YVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNI 168
           Y+NL  + +GP G + IA  L  N  +  L +  N I  +G +    MLQ N  L+++++
Sbjct: 142 YLNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDL 201

Query: 169 SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
            +    LE + +      + +  + +L +  +D K      LC AL  N  ++ LD+S N
Sbjct: 202 GD--CDLEESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNSSLRYLDVSCN 259

Query: 229 QFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRG-NVTLTKLDLSMNGFG 287
           + +  G  +L  +L  N  L  +DLS+N     GA  L   L   N +L  L +  N   
Sbjct: 260 KITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIE 319

Query: 288 NEVALALGEVLRLNRCLVYLDIGGN 312
            E  +AL + ++ N    ++ I GN
Sbjct: 320 GEGLVALSQSMKTNLTFSHIYIWGN 344



 Score = 74.7 bits (182), Expect = 2e-13
 Identities = 52/203 (25%), Positives = 98/203 (48%), Gaps = 4/203 (1%)

Query: 103 RNMEESYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYY 162
           +N    Y+ +  + +  +G    A  L  N ++ KL+L D C +EE  + +  ML+EN+ 
Sbjct: 164 KNRTLKYLRMTGNKIENKGGMFFAAMLQINSSLEKLDLGD-CDLEESTVHVGRMLKENHC 222

Query: 163 LQEMNISNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKK 222
           L  +++  + +   G + + D    NSS  + L++S N    D    L   L +N  ++ 
Sbjct: 223 LVALHMCKHDIKNSGIQQLCDALYLNSSLRY-LDVSCNKITHDGMVYLADVLKSNTTLEV 281

Query: 223 LDLSHNQFSDVGGEHLGQMLAI-NVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDL 281
           +DLS N+  + G  +L + L   N  L +L +  NN    G VAL   ++ N+T + + +
Sbjct: 282 IDLSFNRIENAGANYLSETLTSHNRSLKALSVVSNNIEGEGLVALSQSMKTNLTFSHIYI 341

Query: 282 SMNGFGNEVALALGEVLRLNRCL 304
             N F     +   +++++  CL
Sbjct: 342 WGNKFDEATCITYSDLIQMG-CL 363



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 69/263 (26%), Positives = 113/263 (42%), Gaps = 8/263 (3%)

Query: 123 KAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIIS 182
           K +A  +  N+A     +    +  E    L ++L+   Y+  +++  N L   GA   +
Sbjct: 72  KGLAAGITLNIAGNNRLVPVERVTGEDFWILSKILKNCLYINGLDVGYNLLCDVGAYYAA 131

Query: 183 DFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQML 242
              ++  + I+ L L  ND   +   L+ + L  N  +K L ++ N+  + GG     ML
Sbjct: 132 KLLQKQLNLIY-LNLMFNDIGPEGGELIAKVLHKNRTLKYLRMTGNKIENKGGMFFAAML 190

Query: 243 AINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLNR 302
            IN  L  LDL   +      V +   L+ N  L  L +  +   N     L + L LN 
Sbjct: 191 QINSSLEKLDLGDCDLE-ESTVHVGRMLKENHCLVALHMCKHDIKNSGIQQLCDALYLNS 249

Query: 303 CLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAILLILAIKRNPKSRM 362
            L YLD+  N I ++G   ++  L+SN +L V+ L  N I   GA  L   +  + +S  
Sbjct: 250 SLRYLDVSCNKITHDGMVYLADVLKSNTTLEVIDLSFNRIENAGANYLSETLTSHNRSLK 309

Query: 363 EELDISNVLVSE------QFMKT 379
               +SN +  E      Q MKT
Sbjct: 310 ALSVVSNNIEGEGLVALSQSMKT 332


>gi|116268109 nucleotide-binding oligomerization domains 27 [Homo
            sapiens]
          Length = 1866

 Score = 84.7 bits (208), Expect = 2e-16
 Identities = 74/292 (25%), Positives = 126/292 (43%), Gaps = 35/292 (11%)

Query: 129  LVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFER- 187
            L+S   +    L  +C+  EG+  L   L   ++L+E+++SNN    EG + +    E  
Sbjct: 1490 LLSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGK 1549

Query: 188  -------------NSSSI-------------WSLELSGNDFKEDSAALLCQALSTNYQIK 221
                         NSS++              SL L+ N   +     L +AL     ++
Sbjct: 1550 WMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLE 1609

Query: 222  KLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDL 281
            +LDLSHNQ  D G +HL  +L     L  +DLS N+  + G V L   L     L +L L
Sbjct: 1610 ELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELML 1669

Query: 282  SMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNP 341
              N  G+  AL L + L  +  +++L    + +G  GA  +++ L+ +  L  + L  N 
Sbjct: 1670 GCNALGDPTALGLAQELPQHLRVLHLPF--SHLGPGGALSLAQALDGSPHLEEISLAEN- 1726

Query: 342  INMDGAILLILAIKRNPKSRMEELDISNVLVSEQFMKTLDGVYAVHPQLDVV 393
             N+ G +L            + ++D+ +  +  Q  K L   +   P L+V+
Sbjct: 1727 -NLAGGVLRFCM----ELPLLRQIDLVSCKIDNQTAKLLTSSFTSCPALEVI 1773



 Score = 61.6 bits (148), Expect = 2e-09
 Identities = 62/238 (26%), Positives = 109/238 (45%), Gaps = 7/238 (2%)

Query: 110  VNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNIS 169
            ++L+H+ +G  G + +A  L     + K++L  N I   G + L E L     L+E+ + 
Sbjct: 1611 LDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNSISSAGGVQLAESLVLCRRLEELMLG 1670

Query: 170  NNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQ 229
             N LG   A  ++    ++   +  L L  +      A  L QAL  +  ++++ L+ N 
Sbjct: 1671 CNALGDPTALGLAQELPQH---LRVLHLPFSHLGPGGALSLAQALDGSPHLEEISLAEN- 1726

Query: 230  FSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNE 289
              ++ G  L   + + + L  +DL       + A  L +       L  + LS N  G+E
Sbjct: 1727 --NLAGGVLRFCMELPL-LRQIDLVSCKIDNQTAKLLTSSFTSCPALEVILLSWNLLGDE 1783

Query: 290  VALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGA 347
             A  L +VL     L  +D+  N I   GA  +++GL    S++V++L+ NPI  D A
Sbjct: 1784 AAAELAQVLPQMGRLKRVDLEKNQITALGAWLLAEGLAQGSSIQVIRLWNNPIPCDMA 1841



 Score = 60.1 bits (144), Expect = 4e-09
 Identities = 62/219 (28%), Positives = 92/219 (42%), Gaps = 6/219 (2%)

Query: 158  QENYYLQEMNISNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKED---SAALLCQAL 214
            +EN     + +++  LG   + ++    E   + +  L LS  +  ED   S+ LL   L
Sbjct: 1432 EENPEAVALRLAHCDLGAHHSLLVGQLME-TCARLQQLSLSQVNLCEDDDASSLLLQSLL 1490

Query: 215  STNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNV 274
             +  ++K   L+ +  S  G  HL   L     L  LDLS N F   G  AL   L G  
Sbjct: 1491 LSLSELKTFRLTSSCVSTEGLAHLASGLGHCHHLEELDLSNNQFDEEGTKALMRALEGKW 1550

Query: 275  TLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRV 334
             L +LDLS     +     L   L    CL  L +  N IG+ G   +S+ L +  SL  
Sbjct: 1551 MLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLNRNSIGDVGCCHLSEALRAATSLEE 1610

Query: 335  LKLFLNPINMDGAILLILAIKRNPKSRMEELDISNVLVS 373
            L L  N I   G   L   +   P+ R  ++D+S   +S
Sbjct: 1611 LDLSHNQIGDAGVQHLATILPGLPELR--KIDLSGNSIS 1647



 Score = 54.7 bits (130), Expect = 2e-07
 Identities = 66/291 (22%), Positives = 113/291 (38%), Gaps = 51/291 (17%)

Query: 110  VNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNIS 169
            ++L+++     GTKA+  AL     + +L+L    +    +  L   L +   LQ + ++
Sbjct: 1527 LDLSNNQFDEEGTKALMRALEGKWMLKRLDLSHLLLNSSTLALLTHRLSQMTCLQSLRLN 1586

Query: 170  NNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQ 229
             N +G  G   +S+   R ++S+  L+LS N   +     L   L    +++K+DLS N 
Sbjct: 1587 RNSIGDVGCCHLSEAL-RAATSLEELDLSHNQIGDAGVQHLATILPGLPELRKIDLSGNS 1645

Query: 230  FSDVGGEHLGQMLAINVGLTSLDLSWNNF--------------HTR------------GA 263
             S  GG  L + L +   L  L L  N                H R            GA
Sbjct: 1646 ISSAGGVQLAESLVLCRRLEELMLGCNALGDPTALGLAQELPQHLRVLHLPFSHLGPGGA 1705

Query: 264  VALCNGLRGNVTLTKLDLSMNGFG------------------------NEVALALGEVLR 299
            ++L   L G+  L ++ L+ N                           N+ A  L     
Sbjct: 1706 LSLAQALDGSPHLEEISLAENNLAGGVLRFCMELPLLRQIDLVSCKIDNQTAKLLTSSFT 1765

Query: 300  LNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAILL 350
                L  + +  N +G+E A+++++ L     L+ + L  N I   GA LL
Sbjct: 1766 SCPALEVILLSWNLLGDEAAAELAQVLPQMGRLKRVDLEKNQITALGAWLL 1816



 Score = 48.9 bits (115), Expect = 1e-05
 Identities = 97/397 (24%), Positives = 152/397 (38%), Gaps = 54/397 (13%)

Query: 51   SPPTVEKVKPARENSETDLEIEDDEKFFTTGQK-ELYLEACKLMGVVPVSYFIRNMEES- 108
            SPPT    +  R     DL+  D ++     +   L L+ C+L  V      I  ++E  
Sbjct: 815  SPPTETTAELQRA---PDLQESDGQRKGAQSRSLTLRLQKCQLQ-VHDAEALIALLQEGP 870

Query: 109  ---YVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQE 165
                V+L+ + L   G + +A A        KL+L DN +   GV  ++  +   + L E
Sbjct: 871  HLEEVDLSGNQLEDEGCRLMAEAASQLHIARKLDLSDNGLSVAGVHCVLRAVSACWTLAE 930

Query: 166  MNISNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQAL-----STNYQI 220
            ++IS  H              +    +++ E       ++ AA L   +           
Sbjct: 931  LHISLQH--------------KTVIFMFAQEPEEQKGPQERAAFLDSLMLQMPSELPLSS 976

Query: 221  KKLDLSHNQFSDVGGEHLGQML--AINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTK 278
            +++ L+H    +   E L + L  + ++G   LD S N     GA  L   L G   L  
Sbjct: 977  RRMRLTHCGLQEKHLEQLCKALGGSCHLGHLHLDFSGNALGDEGAARLAQLLPGLGALQS 1036

Query: 279  LDLSMNGFGNEVALALGEVLRLNRCLVYLDIG--GNDIGNEGASKISKGLESNESL---- 332
            L+LS NG   +  L L       + L  LDI      I   G  K S+ + +  SL    
Sbjct: 1037 LNLSENGLSLDAVLGLVRCFSTLQWLFRLDISFESQHILLRG-DKTSRDMWATGSLPDFP 1095

Query: 333  --------------RVLKLFLNPINMDGAILLILAIKRNPKSRMEELDISNVLVSEQFMK 378
                          R L L   P+       L   +K  P     EL +S   +S+Q ++
Sbjct: 1096 AAAKFLGFRQRCIPRSLCLSECPLEPPSLTRLCATLKDCPGPL--ELQLSCEFLSDQSLE 1153

Query: 379  TLDGVYAVHPQLDVVFKAVQGLSPKKTIFLLTNPMKL 415
            TL       PQL ++  +  GLSPK   FLL N + L
Sbjct: 1154 TLLDCLPQLPQLSLLQLSQTGLSPKSP-FLLANTLSL 1189


>gi|229577123 t-complex-associated testis expressed 1 [Homo sapiens]
          Length = 501

 Score = 81.6 bits (200), Expect = 1e-15
 Identities = 54/180 (30%), Positives = 91/180 (50%), Gaps = 2/180 (1%)

Query: 123 KAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIIS 182
           + I  +L+ +  + +L+L  N I + G     ++L  +  L+ +N++NN +   GA+ ++
Sbjct: 297 RIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLSHSR-LRVLNLANNQVRAPGAQSLA 355

Query: 183 DFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQML 242
                N++ I SL L  N  +++    L  AL TN  +  L L  N+ S+     L Q+L
Sbjct: 356 HALAHNTNLI-SLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELSEPTATLLSQVL 414

Query: 243 AINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLNR 302
           AIN  LTS++LS N+    G   L  G+  N TL + DL ++    E    +G+ L  NR
Sbjct: 415 AINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESEYLIGQALYANR 474



 Score = 78.6 bits (192), Expect = 1e-14
 Identities = 51/182 (28%), Positives = 93/182 (51%), Gaps = 1/182 (0%)

Query: 196 ELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSW 255
           +L+ +   +D A ++ ++L  +  +++LDLS N   D G     ++L+ +  L  L+L+ 
Sbjct: 285 KLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAKLLS-HSRLRVLNLAN 343

Query: 256 NNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIG 315
           N     GA +L + L  N  L  L+L +N   +E   AL   L+ N+CL  L +GGN++ 
Sbjct: 344 NQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLGGNELS 403

Query: 316 NEGASKISKGLESNESLRVLKLFLNPINMDGAILLILAIKRNPKSRMEELDISNVLVSEQ 375
              A+ +S+ L  N +L  + L  N I +DG   L+  +  N      +L +S+V    +
Sbjct: 404 EPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDLRLSDVAQESE 463

Query: 376 FM 377
           ++
Sbjct: 464 YL 465



 Score = 72.0 bits (175), Expect = 1e-12
 Identities = 56/210 (26%), Positives = 96/210 (45%), Gaps = 2/210 (0%)

Query: 120 RGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGAR 179
           R   ++A A+ +   +   +L  + + ++    ++  L ++  L+E+++S N +G  GAR
Sbjct: 266 RDCLSLAAAIKACHTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGAR 325

Query: 180 IISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLG 239
             +     +   +  L L+ N  +   A  L  AL+ N  +  L+L  N   D GG+ L 
Sbjct: 326 GAAKLLSHSRLRV--LNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALA 383

Query: 240 QMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLR 299
             L  N  LT+L L  N      A  L   L  N TLT ++LS N  G +    L E + 
Sbjct: 384 HALQTNKCLTTLHLGGNELSEPTATLLSQVLAINTTLTSINLSCNHIGLDGGKQLLEGMS 443

Query: 300 LNRCLVYLDIGGNDIGNEGASKISKGLESN 329
            N+ L+  D+  +D+  E    I + L +N
Sbjct: 444 DNKTLLEFDLRLSDVAQESEYLIGQALYAN 473



 Score = 53.9 bits (128), Expect = 3e-07
 Identities = 42/139 (30%), Positives = 67/139 (48%), Gaps = 7/139 (5%)

Query: 110 VNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNIS 169
           +NL ++ +   G +++A AL  N  +  L L  NCI +EG  +L   LQ N  L  +++ 
Sbjct: 339 LNLANNQVRAPGAQSLAHALAHNTNLISLNLRLNCIEDEGGQALAHALQTNKCLTTLHLG 398

Query: 170 NNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQ 229
            N L    A ++S     N +++ S+ LS N    D    L + +S N  + + DL   +
Sbjct: 399 GNELSEPTATLLSQVLAIN-TTLTSINLSCNHIGLDGGKQLLEGMSDNKTLLEFDL---R 454

Query: 230 FSDVGGEH---LGQMLAIN 245
            SDV  E    +GQ L  N
Sbjct: 455 LSDVAQESEYLIGQALYAN 473



 Score = 38.9 bits (89), Expect = 0.011
 Identities = 40/144 (27%), Positives = 67/144 (46%), Gaps = 6/144 (4%)

Query: 219 QIKKLDLSHNQFSDV--GGEHLGQM-LAINVGLTSLDLSWNNF--HTRGAVALCNGLRGN 273
           ++++  + H Q  D+  G  HL ++ L  +V    ++  WN F    R  ++L   ++  
Sbjct: 219 EMEEPTVDHYQLGDLVAGLSHLEELDLVYDVKDCGMNFEWNLFLFTYRDCLSLAAAIKAC 278

Query: 274 VTLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLR 333
            TL    L+ +   ++ A  +   L  +  L  LD+  N IG+ GA   +K L S+  LR
Sbjct: 279 HTLKIFKLTRSKVDDDKARIIIRSLLDHPVLEELDLSQNLIGDRGARGAAK-LLSHSRLR 337

Query: 334 VLKLFLNPINMDGAILLILAIKRN 357
           VL L  N +   GA  L  A+  N
Sbjct: 338 VLNLANNQVRAPGAQSLAHALAHN 361


>gi|5174617 nucleotide-binding oligomerization domain containing 1
           [Homo sapiens]
          Length = 953

 Score = 81.3 bits (199), Expect = 2e-15
 Identities = 59/213 (27%), Positives = 103/213 (48%), Gaps = 1/213 (0%)

Query: 135 VTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNSSSIWS 194
           +T L L  N I + GV  L E L +   +  + + NN +   GAR ++   +     +  
Sbjct: 730 LTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLYNNQITDVGARYVTKILDE-CKGLTH 788

Query: 195 LELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLS 254
           L+L  N    +    L  A+  +  I ++ +  NQ  D G +   + L  +  LT+L L+
Sbjct: 789 LKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQVGDEGAKAFAEALRNHPSLTTLSLA 848

Query: 255 WNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDI 314
            N   T G  +L   L+ N +L  L L+ N   +EVA +L E+L++N+ L +L +  N I
Sbjct: 849 SNGISTEGGKSLARALQQNTSLEILWLTQNELNDEVAESLAEMLKVNQTLKHLWLIQNQI 908

Query: 315 GNEGASKISKGLESNESLRVLKLFLNPINMDGA 347
             +G ++++  L+SN  +  + L  N I  + A
Sbjct: 909 TAKGTAQLADALQSNTGITEICLNGNLIKPEEA 941



 Score = 79.0 bits (193), Expect = 9e-15
 Identities = 55/192 (28%), Positives = 93/192 (48%), Gaps = 4/192 (2%)

Query: 166 MNISNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDL 225
           +++ NN+L   G R +   F R    +  L LS N   +    +L + L+    +  L L
Sbjct: 708 LDLDNNNLNDYGVRELQPCFSR----LTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGL 763

Query: 226 SHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNG 285
            +NQ +DVG  ++ ++L    GLT L L  N   + G   L   ++ + +++++ +  N 
Sbjct: 764 YNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQ 823

Query: 286 FGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMD 345
            G+E A A  E LR +  L  L +  N I  EG   +++ L+ N SL +L L  N +N +
Sbjct: 824 VGDEGAKAFAEALRNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQNELNDE 883

Query: 346 GAILLILAIKRN 357
            A  L   +K N
Sbjct: 884 VAESLAEMLKVN 895



 Score = 70.5 bits (171), Expect = 3e-12
 Identities = 48/177 (27%), Positives = 86/177 (48%), Gaps = 1/177 (0%)

Query: 108 SYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMN 167
           +Y+ L ++ +   G + +   L     +T L+L  N I  EG   L   ++ +  + E+ 
Sbjct: 759 TYLGLYNNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVG 818

Query: 168 ISNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSH 227
           +  N +G EGA+  ++   RN  S+ +L L+ N    +    L +AL  N  ++ L L+ 
Sbjct: 819 MWGNQVGDEGAKAFAEAL-RNHPSLTTLSLASNGISTEGGKSLARALQQNTSLEILWLTQ 877

Query: 228 NQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMN 284
           N+ +D   E L +ML +N  L  L L  N    +G   L + L+ N  +T++ L+ N
Sbjct: 878 NELNDEVAESLAEMLKVNQTLKHLWLIQNQITAKGTAQLADALQSNTGITEICLNGN 934



 Score = 43.5 bits (101), Expect = 4e-04
 Identities = 40/172 (23%), Positives = 80/172 (46%), Gaps = 5/172 (2%)

Query: 223 LDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLS 282
           LDL +N  +D G   L    +    LT L LS N     G   L   L     +T L L 
Sbjct: 708 LDLDNNNLNDYGVRELQPCFS---RLTVLRLSVNQITDGGVKVLSEELTKYKIVTYLGLY 764

Query: 283 MNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPI 342
            N   +  A  + ++L   + L +L +G N I +EG   ++  +++++S+  + ++ N +
Sbjct: 765 NNQITDVGARYVTKILDECKGLTHLKLGKNKITSEGGKYLALAVKNSKSISEVGMWGNQV 824

Query: 343 NMDGAILLILAIKRNPKSRMEELDISNVLVSEQFMKTLDGVYAVHPQLDVVF 394
             +GA     A++ +P   +  L +++  +S +  K+L      +  L++++
Sbjct: 825 GDEGAKAFAEALRNHPS--LTTLSLASNGISTEGGKSLARALQQNTSLEILW 874


>gi|11545912 nucleotide-binding oligomerization domain containing 2
            [Homo sapiens]
          Length = 1040

 Score = 79.3 bits (194), Expect = 7e-15
 Identities = 71/257 (27%), Positives = 114/257 (44%), Gaps = 8/257 (3%)

Query: 103  RNMEESYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQ--EN 160
            R +   ++ L    +GP    A+A  L        L+L+ N + + GV  L+  L   + 
Sbjct: 760  RGLNVGHLKLTFCSVGPTECAALAFVLQHLRRPVALQLDYNSVGDIGVEQLLPCLGVCKA 819

Query: 161  YYLQEMNISNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQI 220
             YL++ NIS+  +     ++I      +   +  L L  N   +  A  + + L+     
Sbjct: 820  LYLRDNNISDRGI----CKLIECAL--HCEQLQKLALFNNKLTDGCAHSMAKLLACRQNF 873

Query: 221  KKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLD 280
              L L +N  +  G + L + L  N  L  L    N     GA AL   L  + +L  L 
Sbjct: 874  LALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLS 933

Query: 281  LSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLN 340
            L  N  G+  A AL  +L  N  L  L +  N + +EG   +++GL+ N SL++LKL  N
Sbjct: 934  LVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNN 993

Query: 341  PINMDGAILLILAIKRN 357
             I   GA  L+ A++RN
Sbjct: 994  CITYLGAEALLQALERN 1010



 Score = 70.9 bits (172), Expect = 3e-12
 Identities = 56/211 (26%), Positives = 96/211 (45%), Gaps = 1/211 (0%)

Query: 112  LNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNN 171
            L  + +  RG   +    +    + KL L +N + +    S+ ++L        + + NN
Sbjct: 822  LRDNNISDRGICKLIECALHCEQLQKLALFNNKLTDGCAHSMAKLLACRQNFLALRLGNN 881

Query: 172  HLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFS 231
            ++   GA+++++   R ++S+  L   GN   ++ A  L +AL  +  ++ L L  N   
Sbjct: 882  YITAAGAQVLAEGL-RGNTSLQFLGFWGNRVGDEGAQALAEALGDHQSLRWLSLVGNNIG 940

Query: 232  DVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVA 291
             VG + L  MLA NV L  L L  N+    G  +L  GL+ N +L  L LS N      A
Sbjct: 941  SVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKLSNNCITYLGA 1000

Query: 292  LALGEVLRLNRCLVYLDIGGNDIGNEGASKI 322
             AL + L  N  ++ + + GN    E   K+
Sbjct: 1001 EALLQALERNDTILEVWLRGNTFSLEEVDKL 1031



 Score = 56.2 bits (134), Expect = 6e-08
 Identities = 33/94 (35%), Positives = 56/94 (59%), Gaps = 1/94 (1%)

Query: 109  YVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNI 168
            +++L  + +G  G +A+A+ L  N+ + +L LE+N + +EGV SL E L++N  L+ + +
Sbjct: 931  WLSLVGNNIGSVGAQALALMLAKNVMLEELCLEENHLQDEGVCSLAEGLKKNSSLKILKL 990

Query: 169  SNNHLGLEGARIISDFFERNSSSIWSLELSGNDF 202
            SNN +   GA  +    ERN  +I  + L GN F
Sbjct: 991  SNNCITYLGAEALLQALERN-DTILEVWLRGNTF 1023



 Score = 47.0 bits (110), Expect = 4e-05
 Identities = 42/148 (28%), Positives = 64/148 (43%), Gaps = 3/148 (2%)

Query: 223 LDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLS 282
           L L +N   D+G E L   L +   L   D   NN   RG   L         L KL L 
Sbjct: 795 LQLDYNSVGDIGVEQLLPCLGVCKALYLRD---NNISDRGICKLIECALHCEQLQKLALF 851

Query: 283 MNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPI 342
            N   +  A ++ ++L   +  + L +G N I   GA  +++GL  N SL+ L  + N +
Sbjct: 852 NNKLTDGCAHSMAKLLACRQNFLALRLGNNYITAAGAQVLAEGLRGNTSLQFLGFWGNRV 911

Query: 343 NMDGAILLILAIKRNPKSRMEELDISNV 370
             +GA  L  A+  +   R   L  +N+
Sbjct: 912 GDEGAQALAEALGDHQSLRWLSLVGNNI 939


>gi|158321897 NACHT, LRR and PYD containing protein 5 [Homo sapiens]
          Length = 1200

 Score = 72.8 bits (177), Expect = 7e-13
 Identities = 67/234 (28%), Positives = 113/234 (48%), Gaps = 6/234 (2%)

Query: 94   GVVPVSYFIRNMEESYVNL--NHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVL 151
            GV+P+S  +R  + +   L     G+   G +++A ALVSN ++T L L +N +  EGV 
Sbjct: 910  GVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSNNSLGNEGVN 969

Query: 152  SLVEMLQ-ENYYLQEMNISNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALL 210
             L   ++  +  LQ + ++  HL   G   ++     N S +  L LS N  +++   LL
Sbjct: 970  LLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALALMGN-SWLTHLSLSMNPVEDNGVKLL 1028

Query: 211  CQAL-STNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNG 269
            C+ +   +  ++ L+L     +    E L  +++ +  L SLDL+ N     G  ALC G
Sbjct: 1029 CEVMREPSCHLQDLELVKCHLTAACCESLSCVISRSRHLKSLDLTDNALGDGGVAALCEG 1088

Query: 270  LR-GNVTLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKI 322
            L+  N  L +L L   G  ++   AL   L  NR L  L++  N+   +G  K+
Sbjct: 1089 LKQKNSVLARLGLKACGLTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKL 1142



 Score = 62.4 bits (150), Expect = 9e-10
 Identities = 50/159 (31%), Positives = 78/159 (49%), Gaps = 3/159 (1%)

Query: 112  LNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQE-NYYLQEMNISN 170
            LN   L   G   +A+AL+ N  +T L L  N + + GV  L E+++E + +LQ++ +  
Sbjct: 987  LNQCHLDTAGCGFLALALMGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVK 1046

Query: 171  NHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALST-NYQIKKLDLSHNQ 229
             HL       +S    R S  + SL+L+ N   +   A LC+ L   N  + +L L    
Sbjct: 1047 CHLTAACCESLSCVISR-SRHLKSLDLTDNALGDGGVAALCEGLKQKNSVLARLGLKACG 1105

Query: 230  FSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCN 268
             +    E L   L+ N  LTSL+L  NNF  +G + LC+
Sbjct: 1106 LTSDCCEALSLALSCNRHLTSLNLVQNNFSPKGMMKLCS 1144



 Score = 55.5 bits (132), Expect = 1e-07
 Identities = 51/189 (26%), Positives = 81/189 (42%), Gaps = 3/189 (1%)

Query: 194  SLELSGNDFKEDSAALLCQALS-TNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLD 252
            SL L G   KE+   + C+AL      ++ L L     +      + Q+L  +  L SL 
Sbjct: 841  SLNLGGTHLKEEDVRMACEALKHPKCLLESLRLDCCGLTHACYLKISQILTTSPSLKSLS 900

Query: 253  LSWNNFHTRGAVALCNGLR-GNVTLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGG 311
            L+ N    +G + L + LR     L KL L   G       +L   L  NR L +L +  
Sbjct: 901  LAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLASALVSNRSLTHLCLSN 960

Query: 312  NDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAILLILAIKRNPKSRMEELDISNVL 371
            N +GNEG + + + +       + +L LN  ++D A    LA+     S +  L +S   
Sbjct: 961  NSLGNEGVNLLCRSMRL-PHCSLQRLMLNQCHLDTAGCGFLALALMGNSWLTHLSLSMNP 1019

Query: 372  VSEQFMKTL 380
            V +  +K L
Sbjct: 1020 VEDNGVKLL 1028



 Score = 53.5 bits (127), Expect = 4e-07
 Identities = 52/211 (24%), Positives = 96/211 (45%), Gaps = 4/211 (1%)

Query: 125  IAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYY-LQEMNISNNHLGLEGARIISD 183
            I+  L ++ ++  L L  N + ++GV+ L + L+ +   LQ++ + +  +   G + ++ 
Sbjct: 886  ISQILTTSPSLKSLSLAGNKVTDQGVMPLSDALRVSQCALQKLILEDCGITATGCQSLAS 945

Query: 184  FFERNSSSIWSLELSGNDFKEDSAALLCQALSTNY-QIKKLDLSHNQFSDVGGEHLGQML 242
                N S +  L LS N    +   LLC+++   +  +++L L+       G   L   L
Sbjct: 946  ALVSNRS-LTHLCLSNNSLGNEGVNLLCRSMRLPHCSLQRLMLNQCHLDTAGCGFLALAL 1004

Query: 243  AINVGLTSLDLSWNNFHTRGAVALCNGLRG-NVTLTKLDLSMNGFGNEVALALGEVLRLN 301
              N  LT L LS N     G   LC  +R  +  L  L+L           +L  V+  +
Sbjct: 1005 MGNSWLTHLSLSMNPVEDNGVKLLCEVMREPSCHLQDLELVKCHLTAACCESLSCVISRS 1064

Query: 302  RCLVYLDIGGNDIGNEGASKISKGLESNESL 332
            R L  LD+  N +G+ G + + +GL+   S+
Sbjct: 1065 RHLKSLDLTDNALGDGGVAALCEGLKQKNSV 1095


>gi|21955154 NLR family, pyrin domain containing 12 isoform 2 [Homo
           sapiens]
          Length = 1061

 Score = 71.6 bits (174), Expect = 1e-12
 Identities = 66/262 (25%), Positives = 107/262 (40%), Gaps = 32/262 (12%)

Query: 110 VNLNHHGLGPRGTKAIAIALVS-NMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNI 168
           ++L  + LG RG K +   L   N  +  L L+   I       L   L  N  L  M++
Sbjct: 718 LSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDL 777

Query: 169 SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
           S N +G  G  ++ +        +  ++L     +  +   +   L TN  + +LDL+ N
Sbjct: 778 SGNGVGFPGMMLLCEGLRHPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTGN 837

Query: 229 QFSDVG-----------------------------GEHLGQMLAINVGLTSLDLSWNNFH 259
              D+G                              + L   L++N  L  LDLS N   
Sbjct: 838 ALEDLGLRLLCQGLRHPVCRLRTLWLKICRLTAAACDELASTLSVNQSLRELDLSLNELG 897

Query: 260 TRGAVALCNGLR-GNVTLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEG 318
             G + LC GLR     L  L L +   G+     L  VL+ N  L  LD+  ND+G+ G
Sbjct: 898 DLGVLLLCEGLRHPTCKLQTLRLGICRLGSAACEGLSVVLQANHNLRELDLSFNDLGDWG 957

Query: 319 ASKISKGLESNESLRVLKLFLN 340
              +++GL+ + + R+ KL+L+
Sbjct: 958 LWLLAEGLQ-HPACRLQKLWLD 978



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 58/251 (23%), Positives = 101/251 (40%), Gaps = 17/251 (6%)

Query: 142 DNCIMEEGVLS----LVEMLQENYYLQEMN----ISNNHLGLEGARIISDFFERNSSSIW 193
           D   +++G L     L E+ +E +  Q ++    I  +++  +   ++S F  +   S  
Sbjct: 602 DGSTLQQGSLEFFSCLYEIQEEEFIQQALSHFQVIVVSNIASKMEHMVSSFCLKRCRSAQ 661

Query: 194 SLELSGNDFK---EDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTS 250
            L L G  +    ED A     A +   Q+ +  +  + +S    EHL   L  N  L  
Sbjct: 662 VLHLYGATYSADGEDRARCSAGAHTLLVQLPERTVLLDAYS----EHLAAALCTNPNLIE 717

Query: 251 LDLSWNNFHTRGAVALCNGLR-GNVTLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDI 309
           L L  N   +RG   LC GLR  N  L  L L      +     L   L  N+ L  +D+
Sbjct: 718 LSLYRNALGSRGVKLLCQGLRHPNCKLQNLRLKRCRISSSACEDLSAALIANKNLTRMDL 777

Query: 310 GGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAILLILAIKRNPKSRMEELDISN 369
            GN +G  G   + +GL  +   R+  + L    ++      +A        + ELD++ 
Sbjct: 778 SGNGVGFPGMMLLCEGLR-HPQCRLQMIQLRKCQLESGACQEMASVLGTNPHLVELDLTG 836

Query: 370 VLVSEQFMKTL 380
             + +  ++ L
Sbjct: 837 NALEDLGLRLL 847


>gi|169213924 PREDICTED: leucine rich repeat containing 68 [Homo
           sapiens]
          Length = 625

 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 63/220 (28%), Positives = 106/220 (48%), Gaps = 5/220 (2%)

Query: 124 AIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHL-GLEGARIIS 182
           A A+ + S++AV  L LE+  +    ++ L   L+ N  L+E+ +++N L GL+ +  + 
Sbjct: 225 ARALRIRSSLAV--LHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLG 282

Query: 183 DFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQ-IKKLDLSHNQFSDVGGEHLGQM 241
           +  + N S +  L+L  N   +   A +C+ L    + +  L L +NQ +  G   LG  
Sbjct: 283 NLLKFNCS-LQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMT 341

Query: 242 LAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLN 301
           L     L +L+L  N     G   L NGL  N ++ +L L+      E A+A+ E +  +
Sbjct: 342 LPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAES 401

Query: 302 RCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNP 341
             L+ LD+  N+I   G   +S  L+ N SL  L L   P
Sbjct: 402 PRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREP 441



 Score = 69.3 bits (168), Expect = 7e-12
 Identities = 55/201 (27%), Positives = 88/201 (43%), Gaps = 1/201 (0%)

Query: 110 VNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIME-EGVLSLVEMLQENYYLQEMNI 168
           ++L +  L  R    +A AL  NM + +L L DN +   +    L  +L+ N  LQ +++
Sbjct: 237 LHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDL 296

Query: 169 SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
            NNH+   G   I +  +     + +L L  N       A L   L     ++ L+L HN
Sbjct: 297 RNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHN 356

Query: 229 QFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGN 288
              + G  HL   L  N  +  L L+       GAVA+   +  +  L +LDL  N    
Sbjct: 357 PIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKT 416

Query: 289 EVALALGEVLRLNRCLVYLDI 309
              +AL   L++N  L+ LD+
Sbjct: 417 GGLMALSLALKVNHSLLRLDL 437



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 69/264 (26%), Positives = 107/264 (40%), Gaps = 38/264 (14%)

Query: 137 KLELEDNCIMEEGVLSLVEMLQENYYLQEMNIS-NNHLGLEGARIISDFFERNS------ 189
           + E E   +  +G  +L +M++       +NIS N H+G  G +  +    + S      
Sbjct: 151 RAEAEPPNLYAQGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLD 210

Query: 190 ---------------------SSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
                                SS+  L L           LL  AL  N  +++L L+ N
Sbjct: 211 ARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADN 270

Query: 229 QFSDV-GGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLR----GNVTLTKLDLSM 283
           + + +     LG +L  N  L  LDL  N+    G   +C GL+    G VTL   +  +
Sbjct: 271 KLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQL 330

Query: 284 NGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPIN 343
              G      LG  L   + L  L++G N IGNEG   +  GL SN S+  L L    + 
Sbjct: 331 THTGMAF---LGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLT 387

Query: 344 MDGAILLILAIKRNPKSRMEELDI 367
            +GA+ +   I  +P  R+  LD+
Sbjct: 388 CEGAVAVAEFIAESP--RLLRLDL 409


>gi|169214345 PREDICTED: leucine rich repeat containing 68 [Homo
           sapiens]
          Length = 625

 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 63/220 (28%), Positives = 106/220 (48%), Gaps = 5/220 (2%)

Query: 124 AIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHL-GLEGARIIS 182
           A A+ + S++AV  L LE+  +    ++ L   L+ N  L+E+ +++N L GL+ +  + 
Sbjct: 225 ARALRIRSSLAV--LHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLG 282

Query: 183 DFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQ-IKKLDLSHNQFSDVGGEHLGQM 241
           +  + N S +  L+L  N   +   A +C+ L    + +  L L +NQ +  G   LG  
Sbjct: 283 NLLKFNCS-LQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMT 341

Query: 242 LAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLN 301
           L     L +L+L  N     G   L NGL  N ++ +L L+      E A+A+ E +  +
Sbjct: 342 LPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAES 401

Query: 302 RCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNP 341
             L+ LD+  N+I   G   +S  L+ N SL  L L   P
Sbjct: 402 PRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREP 441



 Score = 69.3 bits (168), Expect = 7e-12
 Identities = 55/201 (27%), Positives = 88/201 (43%), Gaps = 1/201 (0%)

Query: 110 VNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIME-EGVLSLVEMLQENYYLQEMNI 168
           ++L +  L  R    +A AL  NM + +L L DN +   +    L  +L+ N  LQ +++
Sbjct: 237 LHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDL 296

Query: 169 SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
            NNH+   G   I +  +     + +L L  N       A L   L     ++ L+L HN
Sbjct: 297 RNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHN 356

Query: 229 QFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGN 288
              + G  HL   L  N  +  L L+       GAVA+   +  +  L +LDL  N    
Sbjct: 357 PIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKT 416

Query: 289 EVALALGEVLRLNRCLVYLDI 309
              +AL   L++N  L+ LD+
Sbjct: 417 GGLMALSLALKVNHSLLRLDL 437



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 69/264 (26%), Positives = 107/264 (40%), Gaps = 38/264 (14%)

Query: 137 KLELEDNCIMEEGVLSLVEMLQENYYLQEMNIS-NNHLGLEGARIISDFFERNS------ 189
           + E E   +  +G  +L +M++       +NIS N H+G  G +  +    + S      
Sbjct: 151 RAEAEPPNLYAQGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLD 210

Query: 190 ---------------------SSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
                                SS+  L L           LL  AL  N  +++L L+ N
Sbjct: 211 ARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADN 270

Query: 229 QFSDV-GGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLR----GNVTLTKLDLSM 283
           + + +     LG +L  N  L  LDL  N+    G   +C GL+    G VTL   +  +
Sbjct: 271 KLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQL 330

Query: 284 NGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPIN 343
              G      LG  L   + L  L++G N IGNEG   +  GL SN S+  L L    + 
Sbjct: 331 THTGMAF---LGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLT 387

Query: 344 MDGAILLILAIKRNPKSRMEELDI 367
            +GA+ +   I  +P  R+  LD+
Sbjct: 388 CEGAVAVAEFIAESP--RLLRLDL 409


>gi|169213302 PREDICTED: leucine rich repeat containing 68 [Homo
           sapiens]
          Length = 625

 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 63/220 (28%), Positives = 106/220 (48%), Gaps = 5/220 (2%)

Query: 124 AIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHL-GLEGARIIS 182
           A A+ + S++AV  L LE+  +    ++ L   L+ N  L+E+ +++N L GL+ +  + 
Sbjct: 225 ARALRIRSSLAV--LHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLG 282

Query: 183 DFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQ-IKKLDLSHNQFSDVGGEHLGQM 241
           +  + N S +  L+L  N   +   A +C+ L    + +  L L +NQ +  G   LG  
Sbjct: 283 NLLKFNCS-LQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMT 341

Query: 242 LAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLN 301
           L     L +L+L  N     G   L NGL  N ++ +L L+      E A+A+ E +  +
Sbjct: 342 LPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAES 401

Query: 302 RCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNP 341
             L+ LD+  N+I   G   +S  L+ N SL  L L   P
Sbjct: 402 PRLLRLDLRENEIKTGGLMALSLALKVNHSLLRLDLDREP 441



 Score = 69.3 bits (168), Expect = 7e-12
 Identities = 55/201 (27%), Positives = 88/201 (43%), Gaps = 1/201 (0%)

Query: 110 VNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIME-EGVLSLVEMLQENYYLQEMNI 168
           ++L +  L  R    +A AL  NM + +L L DN +   +    L  +L+ N  LQ +++
Sbjct: 237 LHLENASLSGRPLMLLATALKMNMNLRELYLADNKLNGLQDSAQLGNLLKFNCSLQILDL 296

Query: 169 SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
            NNH+   G   I +  +     + +L L  N       A L   L     ++ L+L HN
Sbjct: 297 RNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQLTHTGMAFLGMTLPHTQSLETLNLGHN 356

Query: 229 QFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGN 288
              + G  HL   L  N  +  L L+       GAVA+   +  +  L +LDL  N    
Sbjct: 357 PIGNEGVRHLKNGLISNRSVLRLGLASTKLTCEGAVAVAEFIAESPRLLRLDLRENEIKT 416

Query: 289 EVALALGEVLRLNRCLVYLDI 309
              +AL   L++N  L+ LD+
Sbjct: 417 GGLMALSLALKVNHSLLRLDL 437



 Score = 68.9 bits (167), Expect = 1e-11
 Identities = 69/264 (26%), Positives = 107/264 (40%), Gaps = 38/264 (14%)

Query: 137 KLELEDNCIMEEGVLSLVEMLQENYYLQEMNIS-NNHLGLEGARIISDFFERNS------ 189
           + E E   +  +G  +L +M++       +NIS N H+G  G +  +    + S      
Sbjct: 151 RAEAEPPNLYAQGASALFDMIEYYESATHLNISFNKHIGTRGWQAAAHMMRKTSCLQYLD 210

Query: 190 ---------------------SSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
                                SS+  L L           LL  AL  N  +++L L+ N
Sbjct: 211 ARNTPLLDHSAPFVARALRIRSSLAVLHLENASLSGRPLMLLATALKMNMNLRELYLADN 270

Query: 229 QFSDV-GGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLR----GNVTLTKLDLSM 283
           + + +     LG +L  N  L  LDL  N+    G   +C GL+    G VTL   +  +
Sbjct: 271 KLNGLQDSAQLGNLLKFNCSLQILDLRNNHVLDSGLAYICEGLKEQRKGLVTLVLWNNQL 330

Query: 284 NGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPIN 343
              G      LG  L   + L  L++G N IGNEG   +  GL SN S+  L L    + 
Sbjct: 331 THTGMAF---LGMTLPHTQSLETLNLGHNPIGNEGVRHLKNGLISNRSVLRLGLASTKLT 387

Query: 344 MDGAILLILAIKRNPKSRMEELDI 367
            +GA+ +   I  +P  R+  LD+
Sbjct: 388 CEGAVAVAEFIAESP--RLLRLDL 409


>gi|28827813 NLR family, pyrin domain containing 14 [Homo sapiens]
          Length = 1093

 Score = 69.7 bits (169), Expect = 6e-12
 Identities = 74/298 (24%), Positives = 121/298 (40%), Gaps = 34/298 (11%)

Query: 125  IAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQE-NYYLQEMNISNNHLGLEGARIISD 183
            I+ AL+ + ++  L L  N ++++GV  L E L+    YL+ +++ +  L   G   +S 
Sbjct: 778  ISNALIRSQSLIFLNLSTNNLLDDGVQLLCEALRHPKCYLERLSLESCGLTEAGCEYLSL 837

Query: 184  FFERNSSSIWSLELSGNDFKEDSAALLCQALS-TNYQIKKLDLSHNQFSDVGGEHLGQML 242
                N   +  L L+ N   +    L+  AL      +K L L    F+ +  E+L   L
Sbjct: 838  ALISNKR-LTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVLRRCHFTSLSSEYLSTSL 896

Query: 243  AINVGLTSLDLSWNNFHTRGAVALCNGLRG-NVTLTKLDLSMNGFGNEVALALGEVLRLN 301
              N  LT LDL  N     G   LC+  R  +  L  L+L      N   L L  V+  N
Sbjct: 897  LHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGCVLTNACCLDLASVILNN 956

Query: 302  RCLVYLDIGGNDIGNEGAS-----------------------------KISKGLESNESL 332
              L  LD+G ND+ ++G                                +S  L  N+ L
Sbjct: 957  PNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLTSLCCQDLSSALICNKRL 1016

Query: 333  RVLKLFLNPINMDGAILLILAIKRNPKSRMEELDISNVLVSEQFMKTLDGVYAVHPQL 390
              + L  N +  +G + L   +K +PK +++ L +      E+  K L+ V   +P L
Sbjct: 1017 IKMNLTQNTLGYEGIVKLYKVLK-SPKCKLQVLGLCKEAFDEEAQKLLEAVGVSNPHL 1073



 Score = 60.8 bits (146), Expect = 3e-09
 Identities = 55/224 (24%), Positives = 92/224 (41%), Gaps = 30/224 (13%)

Query: 110  VNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQE---------- 159
            ++L   GL   G + +++AL+SN  +T L L DN + + GV  + + LQ           
Sbjct: 820  LSLESCGLTEAGCEYLSLALISNKRLTHLCLADNVLGDGGVKLMSDALQHAQCTLKSLVL 879

Query: 160  -------------------NYYLQEMNISNNHLGLEGARIISDFFERNSSSIWSLELSGN 200
                               N  L  +++ +N L   G +++ D F   S ++  LEL G 
Sbjct: 880  RRCHFTSLSSEYLSTSLLHNKSLTHLDLGSNWLQDNGVKLLCDVFRHPSCNLQDLELMGC 939

Query: 201  DFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAI-NVGLTSLDLSWNNFH 259
                     L   +  N  ++ LDL +N   D G + L   L   N  +  L L +    
Sbjct: 940  VLTNACCLDLASVILNNPNLRSLDLGNNDLQDDGVKILCDALRYPNCNIQRLGLEYCGLT 999

Query: 260  TRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLNRC 303
            +     L + L  N  L K++L+ N  G E  + L +VL+  +C
Sbjct: 1000 SLCCQDLSSALICNKRLIKMNLTQNTLGYEGIVKLYKVLKSPKC 1043



 Score = 43.9 bits (102), Expect = 3e-04
 Identities = 49/167 (29%), Positives = 72/167 (43%), Gaps = 4/167 (2%)

Query: 210 LCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLA-INVGLTSLDLSWNNFHTRGAVALCN 268
           LC  L TN  +++LDL H+         L   L   N  L  L L +  F   G   +  
Sbjct: 665 LCSVLHTNEHLRELDLYHSNLDKSAMNILHHELRHPNCKLQKLLLKFITF-PDGCQDIST 723

Query: 269 GLRGNVTLTKLDLSMNGFGNEVALALGEVLRLNRC-LVYLDIGGNDIGNEGASKISKGLE 327
            L  N  L  LDL  +  G+    +L E L+   C L  L +   ++       IS  L 
Sbjct: 724 SLIHNKNLMHLDLKGSDIGDNGVKSLCEALKHPECKLQTLRLESCNLTVFCCLNISNALI 783

Query: 328 SNESLRVLKLFLNPINMDGAILLILAIKRNPKSRMEELDISNVLVSE 374
            ++SL  L L  N +  DG  LL  A+ R+PK  +E L + +  ++E
Sbjct: 784 RSQSLIFLNLSTNNLLDDGVQLLCEAL-RHPKCYLERLSLESCGLTE 829


>gi|110624785 NACHT, leucine rich repeat and PYD containing 13 [Homo
            sapiens]
          Length = 1043

 Score = 67.8 bits (164), Expect = 2e-11
 Identities = 61/231 (26%), Positives = 104/231 (45%), Gaps = 4/231 (1%)

Query: 109  YVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQE-NYYLQEMN 167
            Y+ L    L     + +A+ L S   VT+L L  N + ++G+  L   L      L+ + 
Sbjct: 814  YLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERLE 873

Query: 168  ISNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALST-NYQIKKLDLS 226
            +    L     + +SD   +N S +  L LS N  +++    LC+AL   +  ++ L+LS
Sbjct: 874  LWFCQLAAPACKHLSDALLQNRS-LTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLS 932

Query: 227  HNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGF 286
               F+  G   L   L+ N  +  LDL  N+    G   LC  L+ +  L  L L+    
Sbjct: 933  GCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEALKPHRALHTLGLAKCNL 992

Query: 287  GNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKL 337
                   L  VL  ++ LV L++ GN++  +G   + K L+ + + R+ KL
Sbjct: 993  TTACCQHLFSVLSSSKSLVNLNLLGNELDTDGVKMLCKALKKS-TCRLQKL 1042



 Score = 67.4 bits (163), Expect = 3e-11
 Identities = 61/212 (28%), Positives = 98/212 (46%), Gaps = 8/212 (3%)

Query: 83   KELYLEACKLMGVV--PVSYFIRNMEE-SYVNLNHHGLGPRGTKAIAIALVS-NMAVTKL 138
            K L LE C L       ++ F+ +++  + + L  + L   G K +  AL     A+ +L
Sbjct: 813  KYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHPKCALERL 872

Query: 139  ELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNSSSIWSLELS 198
            EL    +       L + L +N  L  +N+S N L  EG + + +   R   ++ SL LS
Sbjct: 873  ELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGNLQSLNLS 932

Query: 199  GNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNF 258
            G  F  +    L  ALS N+ +K LDL  N   D G + L + L  +  L +L L+  N 
Sbjct: 933  GCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEALKPHRALHTLGLAKCNL 992

Query: 259  HTRGAVALCNGLRGNVTLTKLDLSMNGFGNEV 290
             T    A C  L   ++ +K  +++N  GNE+
Sbjct: 993  TT----ACCQHLFSVLSSSKSLVNLNLLGNEL 1020



 Score = 67.0 bits (162), Expect = 4e-11
 Identities = 78/302 (25%), Positives = 120/302 (39%), Gaps = 41/302 (13%)

Query: 66  ETDLEIEDDEKFFTTGQKELYLEACKLMGVVPVSYFIRNMEESYVNLNHHGLGPRGTKAI 125
           E DLEI +  KF    +   +   C        S  + N     ++L++  L     K +
Sbjct: 697 ERDLEILETSKF--DSRMHAWNSIC--------STLVTNENLHELDLSNSKLHASSVKGL 746

Query: 126 AIALVSNMAVTKLELEDNCIMEEGVLS-LVEMLQENYYLQEMNISNNHLGLEGARIIS-- 182
            +AL  N      +L    +  E VL  L+  LQ N  L  +N S+N LG+    I+   
Sbjct: 747 CLAL-KNPRCKVQKLTCKSVTPEWVLQDLIIALQGNSKLTHLNFSSNKLGMTVPLILKAL 805

Query: 183 -------------------------DFFERNSSSIWSLELSGNDFKEDSAALLCQALS-T 216
                                      F  +   +  L L  N  ++D   LLC AL+  
Sbjct: 806 RHSACNLKYLCLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDGIKLLCAALTHP 865

Query: 217 NYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGL-RGNVT 275
              +++L+L   Q +    +HL   L  N  LT L+LS N+    G   LC  L R +  
Sbjct: 866 KCALERLELWFCQLAAPACKHLSDALLQNRSLTHLNLSKNSLRDEGVKFLCEALGRPDGN 925

Query: 276 LTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVL 335
           L  L+LS   F  E    L   L  N  +  LD+G ND+ ++G   + + L+ + +L  L
Sbjct: 926 LQSLNLSGCSFTREGCGELANALSHNHNVKILDLGENDLQDDGVKLLCEALKPHRALHTL 985

Query: 336 KL 337
            L
Sbjct: 986 GL 987



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 47/180 (26%), Positives = 77/180 (42%), Gaps = 15/180 (8%)

Query: 195 LELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLS 254
           LE S  D +  +   +C  L TN  + +LDLS+++       H   +  + + L +    
Sbjct: 703 LETSKFDSRMHAWNSICSTLVTNENLHELDLSNSKL------HASSVKGLCLALKNPRCK 756

Query: 255 WNNFHTRGAVA------LCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLNRC-LVYL 307
                 +          L   L+GN  LT L+ S N  G  V L L + LR + C L YL
Sbjct: 757 VQKLTCKSVTPEWVLQDLIIALQGNSKLTHLNFSSNKLGMTVPLIL-KALRHSACNLKYL 815

Query: 308 DIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAILLILAIKRNPKSRMEELDI 367
            +   ++       ++  L S + +  L L  N +  DG I L+ A   +PK  +E L++
Sbjct: 816 CLEKCNLSAASCQDLALFLTSIQHVTRLCLGFNRLQDDG-IKLLCAALTHPKCALERLEL 874


>gi|4506411 Ran GTPase activating protein 1 [Homo sapiens]
          Length = 587

 Score = 65.9 bits (159), Expect = 8e-11
 Identities = 58/247 (23%), Positives = 109/247 (44%), Gaps = 40/247 (16%)

Query: 129 LVSNMAVTKLELEDNCIMEEGVLSLVEMLQEN--YYLQEMNISNNHLGLEGARI----IS 182
           + +   + +L+L DN    +GV     +L+ +  + LQE+ ++N  +G+ G +I    ++
Sbjct: 108 ITAGAQLVELDLSDNAFGPDGVQGFEALLKSSACFTLQELKLNNCGMGIGGGKILAAALT 167

Query: 183 DFFERNSSSIWSLEL-----SGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEH 237
           +   ++S+    L L       N  + D A  L +A      ++++ +  N  +  G   
Sbjct: 168 ECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHMPQNGINHPGITA 227

Query: 238 LGQMLAINVGLTSLDLSWNNF----------------------------HTRGAVALCNG 269
           L Q  A+N  L  ++L+ N F                             ++GAVA+ + 
Sbjct: 228 LAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLRQVEVINFGDCLVRSKGAVAIADA 287

Query: 270 LRGNV-TLTKLDLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLES 328
           +RG +  L +L+LS      + ALA+ E +     L  LD+ GN +G EG  ++ + LE 
Sbjct: 288 IRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELEKLDLNGNTLGEEGCEQLQEVLEG 347

Query: 329 NESLRVL 335
               +VL
Sbjct: 348 FNMAKVL 354



 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 38/141 (26%), Positives = 72/141 (51%), Gaps = 2/141 (1%)

Query: 102 IRNMEESYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENY 161
           I  +EE  V++  +G+   G  A+A A   N  +  + L DN   E+G +++ E L+   
Sbjct: 207 IGTLEE--VHMPQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLKTLR 264

Query: 162 YLQEMNISNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIK 221
            ++ +N  +  +  +GA  I+D        +  L LS  + K D+A  + +A++   +++
Sbjct: 265 QVEVINFGDCLVRSKGAVAIADAIRGGLPKLKELNLSFCEIKRDAALAVAEAMADKAELE 324

Query: 222 KLDLSHNQFSDVGGEHLGQML 242
           KLDL+ N   + G E L ++L
Sbjct: 325 KLDLNGNTLGEEGCEQLQEVL 345



 Score = 51.2 bits (121), Expect = 2e-06
 Identities = 53/226 (23%), Positives = 96/226 (42%), Gaps = 18/226 (7%)

Query: 148 EGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNSS---SIWSLELSGNDFKE 204
           E    +++ +++   L+ + +  N +G+E AR+I+   E+ S      WS   +G    E
Sbjct: 36  EDAKDVIKEIEDFDSLEALRLEGNTVGVEAARVIAKALEKKSELKRCHWSDMFTGRLRTE 95

Query: 205 DSAALLCQA---LSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWNNFH-- 259
              AL+      ++   Q+ +LDLS N F   G +    +L  +   T  +L  NN    
Sbjct: 96  IPPALISLGEGLITAGAQLVELDLSDNAFGPDGVQGFEALLKSSACFTLQELKLNNCGMG 155

Query: 260 ------TRGAVALC---NGLRGNVTLTKLDLS-MNGFGNEVALALGEVLRLNRCLVYLDI 309
                    A+  C   +  +G     K+ ++  N   N+ A AL E  R+   L  + +
Sbjct: 156 IGGGKILAAALTECHRKSSAQGKPLALKVFVAGRNRLENDGATALAEAFRVIGTLEEVHM 215

Query: 310 GGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAILLILAIK 355
             N I + G + +++    N  LRV+ L  N     GA+ +   +K
Sbjct: 216 PQNGINHPGITALAQAFAVNPLLRVINLNDNTFTEKGAVAMAETLK 261


>gi|119395764 NLR family, pyrin domain containing 3 isoform a [Homo
            sapiens]
          Length = 1036

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 68/302 (22%), Positives = 119/302 (39%), Gaps = 60/302 (19%)

Query: 153  LVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQ 212
            L  +L  +  L E+++S+N LG  G R++ +  +    +I  L L       +    +  
Sbjct: 733  LFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISL 792

Query: 213  ALSTNYQIKKLDLSHNQFSD-------VGGEHL----------------------GQMLA 243
             LS+N ++ +LDLS N   D       VG +HL                        +L+
Sbjct: 793  VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLS 852

Query: 244  INVGLTSLDLSWNNFHTRGAVALCNGLRG-NVTLTKLDLSMNGFGNEVALALGEVLRLNR 302
             +  LT L +  N     G   LC   +     L KL L  +G  +    AL  VL  N+
Sbjct: 853  TSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQ 912

Query: 303  CLVYLDIGGNDIGNEGASKISKGL-----------------------------ESNESLR 333
             L +L + GN +G++G   + +GL                              S++SLR
Sbjct: 913  NLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLR 972

Query: 334  VLKLFLNPINMDGAILLILAIKRNPKSRMEELDISNVLVSEQFMKTLDGVYAVHPQLDVV 393
             L L  N +  D  +++   + +     ++ L +S +  + +    L+ +    P+L VV
Sbjct: 973  KLSLGNNDLG-DLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVV 1031

Query: 394  FK 395
            F+
Sbjct: 1032 FE 1033



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 54/229 (23%), Positives = 94/229 (41%), Gaps = 11/229 (4%)

Query: 110  VNLNHHGLGPRGTKAIAIALVSNMA-VTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNI 168
            ++L+ + LG  G + + + L   +  + KL L   C+       L  +L  ++ L  + +
Sbjct: 803  LDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYV 862

Query: 169  SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
              N LG  G  I+ +  +    ++  L L  +       + L   LSTN  +  L L  N
Sbjct: 863  GENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGN 922

Query: 229  QFSDVGGEHLGQ-MLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFG 287
               D G + L + +L  +  L  L+L   N  +     L   L  + +L KL L  N  G
Sbjct: 923  TLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLG 982

Query: 288  NEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLK 336
            +   +   EVL+   CL         + N G S++    E+  +L  L+
Sbjct: 983  DLGVMMFCEVLKQQSCL---------LQNLGLSEMYFNYETKSALETLQ 1022


>gi|34878693 NLR family, pyrin domain containing 3 isoform a [Homo
            sapiens]
          Length = 1036

 Score = 64.7 bits (156), Expect = 2e-10
 Identities = 68/302 (22%), Positives = 119/302 (39%), Gaps = 60/302 (19%)

Query: 153  LVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQ 212
            L  +L  +  L E+++S+N LG  G R++ +  +    +I  L L       +    +  
Sbjct: 733  LFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISL 792

Query: 213  ALSTNYQIKKLDLSHNQFSD-------VGGEHL----------------------GQMLA 243
             LS+N ++ +LDLS N   D       VG +HL                        +L+
Sbjct: 793  VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLS 852

Query: 244  INVGLTSLDLSWNNFHTRGAVALCNGLRG-NVTLTKLDLSMNGFGNEVALALGEVLRLNR 302
             +  LT L +  N     G   LC   +     L KL L  +G  +    AL  VL  N+
Sbjct: 853  TSHSLTRLYVGENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQ 912

Query: 303  CLVYLDIGGNDIGNEGASKISKGL-----------------------------ESNESLR 333
             L +L + GN +G++G   + +GL                              S++SLR
Sbjct: 913  NLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLR 972

Query: 334  VLKLFLNPINMDGAILLILAIKRNPKSRMEELDISNVLVSEQFMKTLDGVYAVHPQLDVV 393
             L L  N +  D  +++   + +     ++ L +S +  + +    L+ +    P+L VV
Sbjct: 973  KLSLGNNDLG-DLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSALETLQEEKPELTVV 1031

Query: 394  FK 395
            F+
Sbjct: 1032 FE 1033



 Score = 51.6 bits (122), Expect = 2e-06
 Identities = 54/229 (23%), Positives = 94/229 (41%), Gaps = 11/229 (4%)

Query: 110  VNLNHHGLGPRGTKAIAIALVSNMA-VTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNI 168
            ++L+ + LG  G + + + L   +  + KL L   C+       L  +L  ++ L  + +
Sbjct: 803  LDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVSCCLTSACCQDLASVLSTSHSLTRLYV 862

Query: 169  SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
              N LG  G  I+ +  +    ++  L L  +       + L   LSTN  +  L L  N
Sbjct: 863  GENALGDSGVAILCEKAKNPQCNLQKLGLVNSGLTSVCCSALSSVLSTNQNLTHLYLRGN 922

Query: 229  QFSDVGGEHLGQ-MLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFG 287
               D G + L + +L  +  L  L+L   N  +     L   L  + +L KL L  N  G
Sbjct: 923  TLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNNDLG 982

Query: 288  NEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLK 336
            +   +   EVL+   CL         + N G S++    E+  +L  L+
Sbjct: 983  DLGVMMFCEVLKQQSCL---------LQNLGLSEMYFNYETKSALETLQ 1022


>gi|188536116 NLR family, pyrin domain containing 3 isoform c [Homo
           sapiens]
          Length = 979

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 66/255 (25%), Positives = 115/255 (45%), Gaps = 23/255 (9%)

Query: 153 LVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQ 212
           L  +L  +  L E+++S+N LG  G R++ +  +    +I  L L       +    +  
Sbjct: 733 LFSVLSTSQSLTELDLSDNSLGDPGMRVLCETLQHPGCNIRRLWLGRCGLSHECCFDISL 792

Query: 213 ALSTNYQIKKLDLSHNQFSD-------VGGEH----LGQMLAINVGLTSLDLSWNNFHTR 261
            LS+N ++ +LDLS N   D       VG +H    L ++  +N GLTS+  S       
Sbjct: 793 VLSSNQKLVELDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCS------- 845

Query: 262 GAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLNRC-LVYLDIGGNDIGNEGAS 320
              AL + L  N  LT L L  N  G++    L E L    C L  L++   ++ +    
Sbjct: 846 ---ALSSVLSTNQNLTHLYLRGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCW 902

Query: 321 KISKGLESNESLRVLKLFLNPINMDGAILLILAIKRNPKSRMEELDISNVLVSEQFMKTL 380
            +S  L S++SLR L L  N +  D  +++   + +     ++ L +S +  + +    L
Sbjct: 903 DLSTLLTSSQSLRKLSLGNNDLG-DLGVMMFCEVLKQQSCLLQNLGLSEMYFNYETKSAL 961

Query: 381 DGVYAVHPQLDVVFK 395
           + +    P+L VVF+
Sbjct: 962 ETLQEEKPELTVVFE 976



 Score = 38.1 bits (87), Expect = 0.018
 Identities = 37/162 (22%), Positives = 74/162 (45%), Gaps = 10/162 (6%)

Query: 110 VNLNHHGLGPRGTKAIAIALVSNMA-VTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNI 168
           ++L+ + LG  G + + + L   +  + KL L ++ +      +L  +L  N  L  + +
Sbjct: 803 LDLSDNALGDFGIRLLCVGLKHLLCNLKKLWLVNSGLTSVCCSALSSVLSTNQNLTHLYL 862

Query: 169 SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
             N LG +G +++ +        +  LEL   +        L   L+++  ++KL L +N
Sbjct: 863 RGNTLGDKGIKLLCEGLLHPDCKLQVLELDNCNLTSHCCWDLSTLLTSSQSLRKLSLGNN 922

Query: 229 QFSDVG----GEHLGQM--LAINVGLTSLDLSWNNFHTRGAV 264
              D+G     E L Q   L  N+GL+ +   + N+ T+ A+
Sbjct: 923 DLGDLGVMMFCEVLKQQSCLLQNLGLSEM---YFNYETKSAL 961


>gi|42822866 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 77/344 (22%), Positives = 134/344 (38%), Gaps = 61/344 (17%)

Query: 110 VNLNHHGLGPRGTKAIAIALVSNMA-VTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNI 168
           ++L+ + LG  G + +   L+     + KL+LE   +       L  +L+     +E+ +
Sbjct: 118 LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177

Query: 169 SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
           SNN +   G R++    + +   + +L+L       D+   LC  +++   +++L L  N
Sbjct: 178 SNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN 237

Query: 229 QFSDVG-GEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFG 287
           +  DVG  E    +L  +  L +L +       +G   LC  LR   +L +L L+ N  G
Sbjct: 238 KLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELG 297

Query: 288 NEVALALGE-----------------------------VLRLNRCLVYLDIGGN------ 312
           +E A  L E                             VL  NR L+ L I  N      
Sbjct: 298 DEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAG 357

Query: 313 -----------------------DIGNEGASKISKGLESNESLRVLKLFLNPINMDGAIL 349
                                  D+ +   S ++  L +N SLR L L  N +  D  IL
Sbjct: 358 VRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLG-DAGIL 416

Query: 350 LILAIKRNPKSRMEELDISNVLVSEQFMKTLDGVYAVHPQLDVV 393
            ++   R P   +E+L + ++  SE+    L  +    P L V+
Sbjct: 417 QLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVI 460



 Score = 52.4 bits (124), Expect = 9e-07
 Identities = 62/244 (25%), Positives = 104/244 (42%), Gaps = 3/244 (1%)

Query: 110 VNLNHHGLGPRGTKAIAIALVS-NMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNI 168
           +NL  + LG  G   +   L + +  + KL L++ C+   G   L   L+    LQE+++
Sbjct: 61  LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120

Query: 169 SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
           S+N LG  G +++ +        +  L+L        S   L   L      K+L +S+N
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180

Query: 229 QFSDVGGEHLGQMLAIN-VGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFG 287
             ++ G   L Q L  +   L +L L      +     LC  +    +L +L L  N  G
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240

Query: 288 N-EVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDG 346
           +  +A     +L  +  L  L I    I  +G   + + L + ESL+ L L  N +  +G
Sbjct: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300

Query: 347 AILL 350
           A LL
Sbjct: 301 ARLL 304



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 58/262 (22%), Positives = 101/262 (38%), Gaps = 33/262 (12%)

Query: 138 LELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFE----------- 186
           + L+D  + E     +   L+ N  L E+N+ +N LG  G   +    +           
Sbjct: 33  VRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSL 92

Query: 187 -----------------RNSSSIWSLELSGNDFKEDSAALLCQA-LSTNYQIKKLDLSHN 228
                            R   ++  L LS N   +    LLC+  L    +++KL L + 
Sbjct: 93  QNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYC 152

Query: 229 QFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGN-VTLTKLDLSMNGFG 287
             S    E L  +L        L +S N+ +  G   LC GL+ +   L  L L   G  
Sbjct: 153 SLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVT 212

Query: 288 NEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKG-LESNESLRVLKLFLNPINMDG 346
           ++    L  ++     L  L +G N +G+ G +++  G L  +  LR L ++   I   G
Sbjct: 213 SDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKG 272

Query: 347 AILLILAIKRNPKSRMEELDIS 368
              L   ++   K  ++EL ++
Sbjct: 273 CGDLCRVLR--AKESLKELSLA 292


>gi|42822864 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 77/344 (22%), Positives = 134/344 (38%), Gaps = 61/344 (17%)

Query: 110 VNLNHHGLGPRGTKAIAIALVSNMA-VTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNI 168
           ++L+ + LG  G + +   L+     + KL+LE   +       L  +L+     +E+ +
Sbjct: 118 LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177

Query: 169 SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
           SNN +   G R++    + +   + +L+L       D+   LC  +++   +++L L  N
Sbjct: 178 SNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN 237

Query: 229 QFSDVG-GEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFG 287
           +  DVG  E    +L  +  L +L +       +G   LC  LR   +L +L L+ N  G
Sbjct: 238 KLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELG 297

Query: 288 NEVALALGE-----------------------------VLRLNRCLVYLDIGGN------ 312
           +E A  L E                             VL  NR L+ L I  N      
Sbjct: 298 DEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAG 357

Query: 313 -----------------------DIGNEGASKISKGLESNESLRVLKLFLNPINMDGAIL 349
                                  D+ +   S ++  L +N SLR L L  N +  D  IL
Sbjct: 358 VRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLG-DAGIL 416

Query: 350 LILAIKRNPKSRMEELDISNVLVSEQFMKTLDGVYAVHPQLDVV 393
            ++   R P   +E+L + ++  SE+    L  +    P L V+
Sbjct: 417 QLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVI 460



 Score = 52.4 bits (124), Expect = 9e-07
 Identities = 62/244 (25%), Positives = 104/244 (42%), Gaps = 3/244 (1%)

Query: 110 VNLNHHGLGPRGTKAIAIALVS-NMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNI 168
           +NL  + LG  G   +   L + +  + KL L++ C+   G   L   L+    LQE+++
Sbjct: 61  LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120

Query: 169 SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
           S+N LG  G +++ +        +  L+L        S   L   L      K+L +S+N
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180

Query: 229 QFSDVGGEHLGQMLAIN-VGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFG 287
             ++ G   L Q L  +   L +L L      +     LC  +    +L +L L  N  G
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240

Query: 288 N-EVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDG 346
           +  +A     +L  +  L  L I    I  +G   + + L + ESL+ L L  N +  +G
Sbjct: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300

Query: 347 AILL 350
           A LL
Sbjct: 301 ARLL 304



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 58/262 (22%), Positives = 101/262 (38%), Gaps = 33/262 (12%)

Query: 138 LELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFE----------- 186
           + L+D  + E     +   L+ N  L E+N+ +N LG  G   +    +           
Sbjct: 33  VRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSL 92

Query: 187 -----------------RNSSSIWSLELSGNDFKEDSAALLCQA-LSTNYQIKKLDLSHN 228
                            R   ++  L LS N   +    LLC+  L    +++KL L + 
Sbjct: 93  QNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYC 152

Query: 229 QFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGN-VTLTKLDLSMNGFG 287
             S    E L  +L        L +S N+ +  G   LC GL+ +   L  L L   G  
Sbjct: 153 SLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVT 212

Query: 288 NEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKG-LESNESLRVLKLFLNPINMDG 346
           ++    L  ++     L  L +G N +G+ G +++  G L  +  LR L ++   I   G
Sbjct: 213 SDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKG 272

Query: 347 AILLILAIKRNPKSRMEELDIS 368
              L   ++   K  ++EL ++
Sbjct: 273 CGDLCRVLR--AKESLKELSLA 292


>gi|42822868 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 77/344 (22%), Positives = 134/344 (38%), Gaps = 61/344 (17%)

Query: 110 VNLNHHGLGPRGTKAIAIALVSNMA-VTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNI 168
           ++L+ + LG  G + +   L+     + KL+LE   +       L  +L+     +E+ +
Sbjct: 118 LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177

Query: 169 SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
           SNN +   G R++    + +   + +L+L       D+   LC  +++   +++L L  N
Sbjct: 178 SNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN 237

Query: 229 QFSDVG-GEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFG 287
           +  DVG  E    +L  +  L +L +       +G   LC  LR   +L +L L+ N  G
Sbjct: 238 KLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELG 297

Query: 288 NEVALALGE-----------------------------VLRLNRCLVYLDIGGN------ 312
           +E A  L E                             VL  NR L+ L I  N      
Sbjct: 298 DEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAG 357

Query: 313 -----------------------DIGNEGASKISKGLESNESLRVLKLFLNPINMDGAIL 349
                                  D+ +   S ++  L +N SLR L L  N +  D  IL
Sbjct: 358 VRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLG-DAGIL 416

Query: 350 LILAIKRNPKSRMEELDISNVLVSEQFMKTLDGVYAVHPQLDVV 393
            ++   R P   +E+L + ++  SE+    L  +    P L V+
Sbjct: 417 QLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVI 460



 Score = 52.4 bits (124), Expect = 9e-07
 Identities = 62/244 (25%), Positives = 104/244 (42%), Gaps = 3/244 (1%)

Query: 110 VNLNHHGLGPRGTKAIAIALVS-NMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNI 168
           +NL  + LG  G   +   L + +  + KL L++ C+   G   L   L+    LQE+++
Sbjct: 61  LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120

Query: 169 SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
           S+N LG  G +++ +        +  L+L        S   L   L      K+L +S+N
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180

Query: 229 QFSDVGGEHLGQMLAIN-VGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFG 287
             ++ G   L Q L  +   L +L L      +     LC  +    +L +L L  N  G
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240

Query: 288 N-EVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDG 346
           +  +A     +L  +  L  L I    I  +G   + + L + ESL+ L L  N +  +G
Sbjct: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300

Query: 347 AILL 350
           A LL
Sbjct: 301 ARLL 304



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 58/262 (22%), Positives = 101/262 (38%), Gaps = 33/262 (12%)

Query: 138 LELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFE----------- 186
           + L+D  + E     +   L+ N  L E+N+ +N LG  G   +    +           
Sbjct: 33  VRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSL 92

Query: 187 -----------------RNSSSIWSLELSGNDFKEDSAALLCQA-LSTNYQIKKLDLSHN 228
                            R   ++  L LS N   +    LLC+  L    +++KL L + 
Sbjct: 93  QNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYC 152

Query: 229 QFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGN-VTLTKLDLSMNGFG 287
             S    E L  +L        L +S N+ +  G   LC GL+ +   L  L L   G  
Sbjct: 153 SLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVT 212

Query: 288 NEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKG-LESNESLRVLKLFLNPINMDG 346
           ++    L  ++     L  L +G N +G+ G +++  G L  +  LR L ++   I   G
Sbjct: 213 SDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKG 272

Query: 347 AILLILAIKRNPKSRMEELDIS 368
              L   ++   K  ++EL ++
Sbjct: 273 CGDLCRVLR--AKESLKELSLA 292


>gi|42822870 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 77/344 (22%), Positives = 134/344 (38%), Gaps = 61/344 (17%)

Query: 110 VNLNHHGLGPRGTKAIAIALVSNMA-VTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNI 168
           ++L+ + LG  G + +   L+     + KL+LE   +       L  +L+     +E+ +
Sbjct: 118 LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177

Query: 169 SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
           SNN +   G R++    + +   + +L+L       D+   LC  +++   +++L L  N
Sbjct: 178 SNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN 237

Query: 229 QFSDVG-GEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFG 287
           +  DVG  E    +L  +  L +L +       +G   LC  LR   +L +L L+ N  G
Sbjct: 238 KLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELG 297

Query: 288 NEVALALGE-----------------------------VLRLNRCLVYLDIGGN------ 312
           +E A  L E                             VL  NR L+ L I  N      
Sbjct: 298 DEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAG 357

Query: 313 -----------------------DIGNEGASKISKGLESNESLRVLKLFLNPINMDGAIL 349
                                  D+ +   S ++  L +N SLR L L  N +  D  IL
Sbjct: 358 VRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLG-DAGIL 416

Query: 350 LILAIKRNPKSRMEELDISNVLVSEQFMKTLDGVYAVHPQLDVV 393
            ++   R P   +E+L + ++  SE+    L  +    P L V+
Sbjct: 417 QLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVI 460



 Score = 52.4 bits (124), Expect = 9e-07
 Identities = 62/244 (25%), Positives = 104/244 (42%), Gaps = 3/244 (1%)

Query: 110 VNLNHHGLGPRGTKAIAIALVS-NMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNI 168
           +NL  + LG  G   +   L + +  + KL L++ C+   G   L   L+    LQE+++
Sbjct: 61  LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120

Query: 169 SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
           S+N LG  G +++ +        +  L+L        S   L   L      K+L +S+N
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180

Query: 229 QFSDVGGEHLGQMLAIN-VGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFG 287
             ++ G   L Q L  +   L +L L      +     LC  +    +L +L L  N  G
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240

Query: 288 N-EVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDG 346
           +  +A     +L  +  L  L I    I  +G   + + L + ESL+ L L  N +  +G
Sbjct: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300

Query: 347 AILL 350
           A LL
Sbjct: 301 ARLL 304



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 58/262 (22%), Positives = 101/262 (38%), Gaps = 33/262 (12%)

Query: 138 LELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFE----------- 186
           + L+D  + E     +   L+ N  L E+N+ +N LG  G   +    +           
Sbjct: 33  VRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSL 92

Query: 187 -----------------RNSSSIWSLELSGNDFKEDSAALLCQA-LSTNYQIKKLDLSHN 228
                            R   ++  L LS N   +    LLC+  L    +++KL L + 
Sbjct: 93  QNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYC 152

Query: 229 QFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGN-VTLTKLDLSMNGFG 287
             S    E L  +L        L +S N+ +  G   LC GL+ +   L  L L   G  
Sbjct: 153 SLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVT 212

Query: 288 NEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKG-LESNESLRVLKLFLNPINMDG 346
           ++    L  ++     L  L +G N +G+ G +++  G L  +  LR L ++   I   G
Sbjct: 213 SDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKG 272

Query: 347 AILLILAIKRNPKSRMEELDIS 368
              L   ++   K  ++EL ++
Sbjct: 273 CGDLCRVLR--AKESLKELSLA 292


>gi|42822874 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 77/344 (22%), Positives = 134/344 (38%), Gaps = 61/344 (17%)

Query: 110 VNLNHHGLGPRGTKAIAIALVSNMA-VTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNI 168
           ++L+ + LG  G + +   L+     + KL+LE   +       L  +L+     +E+ +
Sbjct: 118 LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177

Query: 169 SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
           SNN +   G R++    + +   + +L+L       D+   LC  +++   +++L L  N
Sbjct: 178 SNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN 237

Query: 229 QFSDVG-GEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFG 287
           +  DVG  E    +L  +  L +L +       +G   LC  LR   +L +L L+ N  G
Sbjct: 238 KLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELG 297

Query: 288 NEVALALGE-----------------------------VLRLNRCLVYLDIGGN------ 312
           +E A  L E                             VL  NR L+ L I  N      
Sbjct: 298 DEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAG 357

Query: 313 -----------------------DIGNEGASKISKGLESNESLRVLKLFLNPINMDGAIL 349
                                  D+ +   S ++  L +N SLR L L  N +  D  IL
Sbjct: 358 VRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLG-DAGIL 416

Query: 350 LILAIKRNPKSRMEELDISNVLVSEQFMKTLDGVYAVHPQLDVV 393
            ++   R P   +E+L + ++  SE+    L  +    P L V+
Sbjct: 417 QLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVI 460



 Score = 52.4 bits (124), Expect = 9e-07
 Identities = 62/244 (25%), Positives = 104/244 (42%), Gaps = 3/244 (1%)

Query: 110 VNLNHHGLGPRGTKAIAIALVS-NMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNI 168
           +NL  + LG  G   +   L + +  + KL L++ C+   G   L   L+    LQE+++
Sbjct: 61  LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120

Query: 169 SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
           S+N LG  G +++ +        +  L+L        S   L   L      K+L +S+N
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180

Query: 229 QFSDVGGEHLGQMLAIN-VGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFG 287
             ++ G   L Q L  +   L +L L      +     LC  +    +L +L L  N  G
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240

Query: 288 N-EVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDG 346
           +  +A     +L  +  L  L I    I  +G   + + L + ESL+ L L  N +  +G
Sbjct: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300

Query: 347 AILL 350
           A LL
Sbjct: 301 ARLL 304



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 58/262 (22%), Positives = 101/262 (38%), Gaps = 33/262 (12%)

Query: 138 LELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFE----------- 186
           + L+D  + E     +   L+ N  L E+N+ +N LG  G   +    +           
Sbjct: 33  VRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSL 92

Query: 187 -----------------RNSSSIWSLELSGNDFKEDSAALLCQA-LSTNYQIKKLDLSHN 228
                            R   ++  L LS N   +    LLC+  L    +++KL L + 
Sbjct: 93  QNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYC 152

Query: 229 QFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGN-VTLTKLDLSMNGFG 287
             S    E L  +L        L +S N+ +  G   LC GL+ +   L  L L   G  
Sbjct: 153 SLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVT 212

Query: 288 NEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKG-LESNESLRVLKLFLNPINMDG 346
           ++    L  ++     L  L +G N +G+ G +++  G L  +  LR L ++   I   G
Sbjct: 213 SDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKG 272

Query: 347 AILLILAIKRNPKSRMEELDIS 368
              L   ++   K  ++EL ++
Sbjct: 273 CGDLCRVLR--AKESLKELSLA 292


>gi|42794608 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 77/344 (22%), Positives = 134/344 (38%), Gaps = 61/344 (17%)

Query: 110 VNLNHHGLGPRGTKAIAIALVSNMA-VTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNI 168
           ++L+ + LG  G + +   L+     + KL+LE   +       L  +L+     +E+ +
Sbjct: 118 LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177

Query: 169 SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
           SNN +   G R++    + +   + +L+L       D+   LC  +++   +++L L  N
Sbjct: 178 SNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN 237

Query: 229 QFSDVG-GEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFG 287
           +  DVG  E    +L  +  L +L +       +G   LC  LR   +L +L L+ N  G
Sbjct: 238 KLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELG 297

Query: 288 NEVALALGE-----------------------------VLRLNRCLVYLDIGGN------ 312
           +E A  L E                             VL  NR L+ L I  N      
Sbjct: 298 DEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAG 357

Query: 313 -----------------------DIGNEGASKISKGLESNESLRVLKLFLNPINMDGAIL 349
                                  D+ +   S ++  L +N SLR L L  N +  D  IL
Sbjct: 358 VRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLG-DAGIL 416

Query: 350 LILAIKRNPKSRMEELDISNVLVSEQFMKTLDGVYAVHPQLDVV 393
            ++   R P   +E+L + ++  SE+    L  +    P L V+
Sbjct: 417 QLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVI 460



 Score = 52.4 bits (124), Expect = 9e-07
 Identities = 62/244 (25%), Positives = 104/244 (42%), Gaps = 3/244 (1%)

Query: 110 VNLNHHGLGPRGTKAIAIALVS-NMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNI 168
           +NL  + LG  G   +   L + +  + KL L++ C+   G   L   L+    LQE+++
Sbjct: 61  LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120

Query: 169 SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
           S+N LG  G +++ +        +  L+L        S   L   L      K+L +S+N
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180

Query: 229 QFSDVGGEHLGQMLAIN-VGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFG 287
             ++ G   L Q L  +   L +L L      +     LC  +    +L +L L  N  G
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240

Query: 288 N-EVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDG 346
           +  +A     +L  +  L  L I    I  +G   + + L + ESL+ L L  N +  +G
Sbjct: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300

Query: 347 AILL 350
           A LL
Sbjct: 301 ARLL 304



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 58/262 (22%), Positives = 101/262 (38%), Gaps = 33/262 (12%)

Query: 138 LELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFE----------- 186
           + L+D  + E     +   L+ N  L E+N+ +N LG  G   +    +           
Sbjct: 33  VRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSL 92

Query: 187 -----------------RNSSSIWSLELSGNDFKEDSAALLCQA-LSTNYQIKKLDLSHN 228
                            R   ++  L LS N   +    LLC+  L    +++KL L + 
Sbjct: 93  QNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYC 152

Query: 229 QFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGN-VTLTKLDLSMNGFG 287
             S    E L  +L        L +S N+ +  G   LC GL+ +   L  L L   G  
Sbjct: 153 SLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVT 212

Query: 288 NEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKG-LESNESLRVLKLFLNPINMDG 346
           ++    L  ++     L  L +G N +G+ G +++  G L  +  LR L ++   I   G
Sbjct: 213 SDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKG 272

Query: 347 AILLILAIKRNPKSRMEELDIS 368
              L   ++   K  ++EL ++
Sbjct: 273 CGDLCRVLR--AKESLKELSLA 292


>gi|42822872 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 77/344 (22%), Positives = 134/344 (38%), Gaps = 61/344 (17%)

Query: 110 VNLNHHGLGPRGTKAIAIALVSNMA-VTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNI 168
           ++L+ + LG  G + +   L+     + KL+LE   +       L  +L+     +E+ +
Sbjct: 118 LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177

Query: 169 SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
           SNN +   G R++    + +   + +L+L       D+   LC  +++   +++L L  N
Sbjct: 178 SNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN 237

Query: 229 QFSDVG-GEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFG 287
           +  DVG  E    +L  +  L +L +       +G   LC  LR   +L +L L+ N  G
Sbjct: 238 KLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELG 297

Query: 288 NEVALALGE-----------------------------VLRLNRCLVYLDIGGN------ 312
           +E A  L E                             VL  NR L+ L I  N      
Sbjct: 298 DEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAG 357

Query: 313 -----------------------DIGNEGASKISKGLESNESLRVLKLFLNPINMDGAIL 349
                                  D+ +   S ++  L +N SLR L L  N +  D  IL
Sbjct: 358 VRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLG-DAGIL 416

Query: 350 LILAIKRNPKSRMEELDISNVLVSEQFMKTLDGVYAVHPQLDVV 393
            ++   R P   +E+L + ++  SE+    L  +    P L V+
Sbjct: 417 QLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVI 460



 Score = 52.4 bits (124), Expect = 9e-07
 Identities = 62/244 (25%), Positives = 104/244 (42%), Gaps = 3/244 (1%)

Query: 110 VNLNHHGLGPRGTKAIAIALVS-NMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNI 168
           +NL  + LG  G   +   L + +  + KL L++ C+   G   L   L+    LQE+++
Sbjct: 61  LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120

Query: 169 SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
           S+N LG  G +++ +        +  L+L        S   L   L      K+L +S+N
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180

Query: 229 QFSDVGGEHLGQMLAIN-VGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFG 287
             ++ G   L Q L  +   L +L L      +     LC  +    +L +L L  N  G
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240

Query: 288 N-EVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDG 346
           +  +A     +L  +  L  L I    I  +G   + + L + ESL+ L L  N +  +G
Sbjct: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300

Query: 347 AILL 350
           A LL
Sbjct: 301 ARLL 304



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 58/262 (22%), Positives = 101/262 (38%), Gaps = 33/262 (12%)

Query: 138 LELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFE----------- 186
           + L+D  + E     +   L+ N  L E+N+ +N LG  G   +    +           
Sbjct: 33  VRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSL 92

Query: 187 -----------------RNSSSIWSLELSGNDFKEDSAALLCQA-LSTNYQIKKLDLSHN 228
                            R   ++  L LS N   +    LLC+  L    +++KL L + 
Sbjct: 93  QNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYC 152

Query: 229 QFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGN-VTLTKLDLSMNGFG 287
             S    E L  +L        L +S N+ +  G   LC GL+ +   L  L L   G  
Sbjct: 153 SLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVT 212

Query: 288 NEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKG-LESNESLRVLKLFLNPINMDG 346
           ++    L  ++     L  L +G N +G+ G +++  G L  +  LR L ++   I   G
Sbjct: 213 SDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKG 272

Query: 347 AILLILAIKRNPKSRMEELDIS 368
              L   ++   K  ++EL ++
Sbjct: 273 CGDLCRVLR--AKESLKELSLA 292


>gi|21361547 ribonuclease/angiogenin inhibitor [Homo sapiens]
          Length = 461

 Score = 64.3 bits (155), Expect = 2e-10
 Identities = 77/344 (22%), Positives = 134/344 (38%), Gaps = 61/344 (17%)

Query: 110 VNLNHHGLGPRGTKAIAIALVSNMA-VTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNI 168
           ++L+ + LG  G + +   L+     + KL+LE   +       L  +L+     +E+ +
Sbjct: 118 LHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTV 177

Query: 169 SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
           SNN +   G R++    + +   + +L+L       D+   LC  +++   +++L L  N
Sbjct: 178 SNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSN 237

Query: 229 QFSDVG-GEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFG 287
           +  DVG  E    +L  +  L +L +       +G   LC  LR   +L +L L+ N  G
Sbjct: 238 KLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELG 297

Query: 288 NEVALALGE-----------------------------VLRLNRCLVYLDIGGN------ 312
           +E A  L E                             VL  NR L+ L I  N      
Sbjct: 298 DEGARLLCETLLEPGCQLESLWVKSCSFTAACCSHFSSVLAQNRFLLELQISNNRLEDAG 357

Query: 313 -----------------------DIGNEGASKISKGLESNESLRVLKLFLNPINMDGAIL 349
                                  D+ +   S ++  L +N SLR L L  N +  D  IL
Sbjct: 358 VRELCQGLGQPGSVLRVLWLADCDVSDSSCSSLAATLLANHSLRELDLSNNCLG-DAGIL 416

Query: 350 LILAIKRNPKSRMEELDISNVLVSEQFMKTLDGVYAVHPQLDVV 393
            ++   R P   +E+L + ++  SE+    L  +    P L V+
Sbjct: 417 QLVESVRQPGCLLEQLVLYDIYWSEEMEDRLQALEKDKPSLRVI 460



 Score = 52.4 bits (124), Expect = 9e-07
 Identities = 62/244 (25%), Positives = 104/244 (42%), Gaps = 3/244 (1%)

Query: 110 VNLNHHGLGPRGTKAIAIALVS-NMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNI 168
           +NL  + LG  G   +   L + +  + KL L++ C+   G   L   L+    LQE+++
Sbjct: 61  LNLRSNELGDVGVHCVLQGLQTPSCKIQKLSLQNCCLTGAGCGVLSSTLRTLPTLQELHL 120

Query: 169 SNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHN 228
           S+N LG  G +++ +        +  L+L        S   L   L      K+L +S+N
Sbjct: 121 SDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYCSLSAASCEPLASVLRAKPDFKELTVSNN 180

Query: 229 QFSDVGGEHLGQMLAIN-VGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFG 287
             ++ G   L Q L  +   L +L L      +     LC  +    +L +L L  N  G
Sbjct: 181 DINEAGVRVLCQGLKDSPCQLEALKLESCGVTSDNCRDLCGIVASKASLRELALGSNKLG 240

Query: 288 N-EVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDG 346
           +  +A     +L  +  L  L I    I  +G   + + L + ESL+ L L  N +  +G
Sbjct: 241 DVGMAELCPGLLHPSSRLRTLWIWECGITAKGCGDLCRVLRAKESLKELSLAGNELGDEG 300

Query: 347 AILL 350
           A LL
Sbjct: 301 ARLL 304



 Score = 47.4 bits (111), Expect = 3e-05
 Identities = 58/262 (22%), Positives = 101/262 (38%), Gaps = 33/262 (12%)

Query: 138 LELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFE----------- 186
           + L+D  + E     +   L+ N  L E+N+ +N LG  G   +    +           
Sbjct: 33  VRLDDCGLTEARCKDISSALRVNPALAELNLRSNELGDVGVHCVLQGLQTPSCKIQKLSL 92

Query: 187 -----------------RNSSSIWSLELSGNDFKEDSAALLCQA-LSTNYQIKKLDLSHN 228
                            R   ++  L LS N   +    LLC+  L    +++KL L + 
Sbjct: 93  QNCCLTGAGCGVLSSTLRTLPTLQELHLSDNLLGDAGLQLLCEGLLDPQCRLEKLQLEYC 152

Query: 229 QFSDVGGEHLGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLRGN-VTLTKLDLSMNGFG 287
             S    E L  +L        L +S N+ +  G   LC GL+ +   L  L L   G  
Sbjct: 153 SLSAASCEPLASVLRAKPDFKELTVSNNDINEAGVRVLCQGLKDSPCQLEALKLESCGVT 212

Query: 288 NEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKG-LESNESLRVLKLFLNPINMDG 346
           ++    L  ++     L  L +G N +G+ G +++  G L  +  LR L ++   I   G
Sbjct: 213 SDNCRDLCGIVASKASLRELALGSNKLGDVGMAELCPGLLHPSSRLRTLWIWECGITAKG 272

Query: 347 AILLILAIKRNPKSRMEELDIS 368
              L   ++   K  ++EL ++
Sbjct: 273 CGDLCRVLR--AKESLKELSLA 292


>gi|63054866 leucine rich repeat containing 16A [Homo sapiens]
          Length = 1326

 Score = 63.2 bits (152), Expect = 5e-10
 Identities = 72/253 (28%), Positives = 123/253 (48%), Gaps = 23/253 (9%)

Query: 131 SNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQ--EMNISNNHLGLEGARIISDFFERN 188
           S++A+  + L    +  E + +L+  L  N+ L+   +++SN  L   GA+++       
Sbjct: 422 SSLALMHINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIAE- 480

Query: 189 SSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAINVG- 247
             +I SL++S N  + D + L+   LS N  I+ L L  N F+++  ++L  +L   V  
Sbjct: 481 IHNITSLDISDNGLESDLSTLIVW-LSKNRSIQHLALGKN-FNNMKSKNLTPVLDNLVQM 538

Query: 248 -------LTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRL 300
                  L SL L+ +   T   + + N L  N +LTK+D+S NG G+  A  L + L++
Sbjct: 539 IQDEESPLQSLSLADSKLKTEVTIII-NALGSNTSLTKVDISGNGMGDMGAKMLAKALQI 597

Query: 301 NRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLNPINMDGAILLILAIKRNPKS 360
           N  L  +    N+I  +G   I+  +E N +LR +     PI M  A     A+K NP+ 
Sbjct: 598 NTKLRTVIWDKNNITAQGFQDIAVAMEKNYTLRFM-----PIPMYDA---SQALKTNPEK 649

Query: 361 RMEELD-ISNVLV 372
             + L  I N L+
Sbjct: 650 TEDALQKIENYLL 662



 Score = 48.5 bits (114), Expect = 1e-05
 Identities = 68/292 (23%), Positives = 119/292 (40%), Gaps = 22/292 (7%)

Query: 107 ESYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEM 166
           + + +L+H  L P     I  AL  N   TKL  +D  +  +    ++ ++  +  L+E+
Sbjct: 197 QDFSHLDHRDLIP-----IIAALEYNQWFTKLSSKDLKLSTDVCEQILRVVSRSNRLEEL 251

Query: 167 NISNNHLGLEGARIISDFFERN-SSSIWSLELSGNDFKEDS-AALLCQALSTNYQIKKLD 224
            + N  L  + A+ ++     N +S + ++ L+GN  ++   ++L  Q       +K L+
Sbjct: 252 VLENAGLRTDFAQKLASALAHNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKGLKHLN 311

Query: 225 LSHNQFSDVGGEHLGQMLAIN----VGLTSLDLSWNNFHTRGAVALCNGLRGNVTLTKLD 280
           LS    S  G   L Q L+ N      L  LDLS N         + N L     +  LD
Sbjct: 312 LSKTSLSPKGVNSLSQSLSANPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLD 371

Query: 281 LSMNGFGNEVALALGEVLRLNRCLVYL-------DIGGNDIGNEGASKISKGLESNESLR 333
           LS      E +L +     L  CL YL        +  +  G E      +   S+ +L 
Sbjct: 372 LS----NTECSLDMVCGALLRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFSSSLALM 427

Query: 334 VLKLFLNPINMDGAILLILAIKRNPKSRMEELDISNVLVSEQFMKTLDGVYA 385
            + L    ++ +    L+L +  N   +   LD+SN  +     + L+G  A
Sbjct: 428 HINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLSNCELRSGGAQVLEGCIA 479



 Score = 41.2 bits (95), Expect = 0.002
 Identities = 66/281 (23%), Positives = 117/281 (41%), Gaps = 43/281 (15%)

Query: 71  IEDDEKFFTTGQKELYLEACKLMGVVPVSYFIRNMEESYVNLNHHGLGPRGTKAIAIALV 130
           +E ++ F     K+L L       ++ V      +EE  + L + GL     + +A AL 
Sbjct: 214 LEYNQWFTKLSSKDLKLSTDVCEQILRVVSRSNRLEE--LVLENAGLRTDFAQKLASALA 271

Query: 131 SN--MAVTKLELEDNCIMEEGVLSL-VEMLQENYYLQEMNISNNHLGLEGARIISDFFER 187
            N    +  + L  N + + GV SL ++  +    L+ +N+S   L  +G   +S     
Sbjct: 272 HNPNSGLHTINLAGNPLEDRGVSSLSIQFAKLPKGLKHLNLSKTSLSPKGVNSLSQSLSA 331

Query: 188 N---SSSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEHLGQMLAI 244
           N   +S++  L+LSGN  + D  + +   L+    I  LDLS+ +               
Sbjct: 332 NPLTASTLVHLDLSGNVLRGDDLSHMYNFLAQPNAIVHLDLSNTE--------------- 376

Query: 245 NVGLTSLDLSWNNFHTRGAVALCNGLRGNVT-LTKLDLSMNGF----GNEVALALGEVLR 299
                SLD+        GA+     LRG +  L  L+LS   F    G EV  +  +   
Sbjct: 377 ----CSLDM------VCGAL-----LRGCLQYLAVLNLSRTVFSHRKGKEVPPSFKQFFS 421

Query: 300 LNRCLVYLDIGGNDIGNEGASKISKGLESNESLRVLKLFLN 340
            +  L+++++ G  +  E    +  GL  N +L+ + L L+
Sbjct: 422 SSLALMHINLSGTKLSPEPLKALLLGLACNHNLKGVSLDLS 462



 Score = 32.0 bits (71), Expect = 1.3
 Identities = 18/65 (27%), Positives = 34/65 (52%)

Query: 104 NMEESYVNLNHHGLGPRGTKAIAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYL 163
           N   + V+++ +G+G  G K +A AL  N  +  +  + N I  +G   +   +++NY L
Sbjct: 570 NTSLTKVDISGNGMGDMGAKMLAKALQINTKLRTVIWDKNNITAQGFQDIAVAMEKNYTL 629

Query: 164 QEMNI 168
           + M I
Sbjct: 630 RFMPI 634


>gi|8923473 NLR family, pyrin domain containing 2 [Homo sapiens]
          Length = 1062

 Score = 59.7 bits (143), Expect = 6e-09
 Identities = 64/242 (26%), Positives = 110/242 (45%), Gaps = 11/242 (4%)

Query: 125  IAIALVSNMAVTKLELEDNCIMEEGVLSLVEMLQE-NYYLQEMNISNNHLGLEGARIISD 183
            +++AL  N ++T + L DN +++EG   L   L+    +LQ +++ N HL     + ++ 
Sbjct: 803  LSLALEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAA 862

Query: 184  FFERNSSSIWSLELSGNDFKEDSAALLCQALS-TNYQIKKLDLSHNQFSDVGGEHLGQML 242
                 S  +  L L+ N         LC+ L     +++ L L +   +  G   L ++L
Sbjct: 863  VLV-VSRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLL 921

Query: 243  AINVGLTSLDLSWNNFHTRGAVALCNGLRGNV----TLTKLDLSMNGFGNEVALALGEVL 298
                 L  LDL  N+   +G   LC  LR  +     L     S+  F  E    L   L
Sbjct: 922  QEKSSLLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCE---DLCSAL 978

Query: 299  RLNRCLVYLDIGGNDIGNEGASKISKGLE-SNESLRVLKLFLNPINMDGAILLILAIKRN 357
              N+ LV LD+G N +G+ G   + + L  S+ +LR L+L ++  N +   LL    ++N
Sbjct: 979  SCNQSLVTLDLGQNPLGSSGVKMLFETLTCSSGTLRTLRLKIDDFNDELNKLLEEIEEKN 1038

Query: 358  PK 359
            P+
Sbjct: 1039 PQ 1040



 Score = 49.7 bits (117), Expect = 6e-06
 Identities = 43/126 (34%), Positives = 64/126 (50%), Gaps = 3/126 (2%)

Query: 266 LCNGLRGNVTLTKLDLSMNGFGNEVALALGEVLRLNRC-LVYLDIGGNDIGNEGASKISK 324
           LC  LRG+ T+T L L  N   +++  AL EVLR   C L YL +       +  + +S 
Sbjct: 747 LCLALRGHKTVTYLTLQGND-QDDMFPALCEVLRHPECNLRYLGLVSCSATTQQWADLSL 805

Query: 325 GLESNESLRVLKLFLNPINMDGAILLILAIKRNPKSRMEELDISNVLVSEQFMKTLDGVY 384
            LE N+SL  + L  N +  +GA LL   + R+PK  ++ L + N  ++E   K L  V 
Sbjct: 806 ALEVNQSLTCVNLSDNELLDEGAKLLYTTL-RHPKCFLQRLSLENCHLTEANCKDLAAVL 864

Query: 385 AVHPQL 390
            V  +L
Sbjct: 865 VVSREL 870



 Score = 47.8 bits (112), Expect = 2e-05
 Identities = 57/236 (24%), Positives = 95/236 (40%), Gaps = 3/236 (1%)

Query: 157  LQENYYLQEMNISNNHLGLEGARIISDFFERNSSSIWSLELSGNDFKEDSAALLCQALST 216
            L+ N  L  +N+S+N L  EGA+++          +  L L      E +   L   L  
Sbjct: 807  LEVNQSLTCVNLSDNELLDEGAKLLYTTLRHPKCFLQRLSLENCHLTEANCKDLAAVLVV 866

Query: 217  NYQIKKLDLSHNQFSDVGGEHLGQMLAINVGLTSLDLSWN-NFHTRGAVALCNGLRGNVT 275
            + ++  L L+ N   + G + L + L          + WN +  + G   L   L+   +
Sbjct: 867  SRELTHLCLAKNPIGNTGVKFLCEGLRYPECKLQTLVLWNCDITSDGCCDLTKLLQEKSS 926

Query: 276  LTKLDLSMNGFGNEVALALGEVLRLNRC-LVYLDIGGNDIGNEGASKISKGLESNESLRV 334
            L  LDL +N  G +    L E LR   C L  L + G  I       +   L  N+SL  
Sbjct: 927  LLCLDLGLNHIGVKGMKFLCEALRKPLCNLRCLWLWGCSIPPFSCEDLCSALSCNQSLVT 986

Query: 335  LKLFLNPINMDGAILLILAIKRNPKSRMEELDISNVLVSEQFMKTLDGVYAVHPQL 390
            L L  NP+   G  +L   +  +    +  L +     +++  K L+ +   +PQL
Sbjct: 987  LDLGQNPLGSSGVKMLFETLTCS-SGTLRTLRLKIDDFNDELNKLLEEIEEKNPQL 1041


>gi|194018484 NLR family, pyrin domain containing 11 [Homo sapiens]
          Length = 1033

 Score = 57.8 bits (138), Expect = 2e-08
 Identities = 61/260 (23%), Positives = 111/260 (42%), Gaps = 36/260 (13%)

Query: 130 VSNMAVTKLELEDNCIMEEGVLSLVEMLQENYYLQEMNISNNHLGLEGARIISDFFERNS 189
           +S++++ K +L  +   E     +  +L     L+++ +S+N L  +G  I+ D     +
Sbjct: 720 ISHLSLMKCDLRASECEE-----IASLLISGGSLRKLTLSSNPLRSDGMNILCDALLHPN 774

Query: 190 SSIWSLELSGNDFKEDSAALLCQALSTNYQIKKLDLSHNQFSDVGGEH------------ 237
            ++ SL L      E+  + L + L  +  +++LDL  N+  + G  H            
Sbjct: 775 CTLISLVLVFCCLTENCCSALGRVLLFSPTLRQLDLCVNRLKNYGVLHVTFPLLFPTCQL 834

Query: 238 -----------------LGQMLAINVGLTSLDLSWNNFHTRGAVALCNGLR-GNVTLTKL 279
                            +  ++A N  L SL++  N     G   LC GLR  N  L  +
Sbjct: 835 EELHLSGCFFSSDICQYIAIVIATNEKLRSLEIGSNKIEDAGMQLLCGGLRHPNCMLVNI 894

Query: 280 DLSMNGFGNEVALALGEVLRLNRCLVYLDIGGNDIGNEGASKISKGLESNES-LRVLKLF 338
            L      +    +L  VL  N+ L  L++  N +GN+G +K+ + L S +  L+V+ L 
Sbjct: 895 GLEECMLTSACCRSLASVLTTNKTLERLNLLQNHLGNDGVAKLLESLISPDCVLKVVGLP 954

Query: 339 LNPINMDGAILLILAIKRNP 358
           L  +N     LL+   +R P
Sbjct: 955 LTGLNTQTQQLLMTVKERKP 974


  Database: hs.faa
    Posted date:  Aug 4, 2009  4:42 PM
  Number of letters in database: 18,247,518
  Number of sequences in database:  37,866
  
Lambda     K      H
   0.317    0.134    0.383 

Gapped
Lambda     K      H
   0.267   0.0410    0.140 


Matrix: BLOSUM62
Gap Penalties: Existence: 11, Extension: 1
Number of Hits to DB: 17,344,260
Number of Sequences: 37866
Number of extensions: 749710
Number of successful extensions: 2696
Number of sequences better than 10.0: 30
Number of HSP's better than 10.0 without gapping: 69
Number of HSP's successfully gapped in prelim test: 26
Number of HSP's that attempted gapping in prelim test: 2043
Number of HSP's gapped (non-prelim): 338
length of query: 488
length of database: 18,247,518
effective HSP length: 106
effective length of query: 382
effective length of database: 14,233,722
effective search space: 5437281804
effective search space used: 5437281804
T: 11
A: 40
X1: 16 ( 7.3 bits)
X2: 38 (14.6 bits)
X3: 64 (24.7 bits)
S1: 41 (21.6 bits)
S2: 64 (29.3 bits)

Search results were obtained with NCBI BLAST and RefSeq entries.

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Guide to the Human Genome
Copyright © 2010 by Stewart Scherer. All rights reserved.